INFO [2024-03-09 21:50:11] Initializing ALASCA (v1.0.15, 2024-02-07) WARN [2024-03-09 21:50:11] Guessing effects: `fold+fold:treatment+treatment` INFO [2024-03-09 21:50:11] Will use linear mixed models! INFO [2024-03-09 21:50:11] Will use Rfast! WARN [2024-03-09 21:50:11] Converting IDs to integer values WARN [2024-03-09 21:50:11] The `fold` column is used for stratification WARN [2024-03-09 21:50:11] Converting `character` columns to factors INFO [2024-03-09 21:50:11] Scaling data with sdall ... INFO [2024-03-09 21:50:11] Calculating LMM coefficients INFO [2024-03-09 21:50:11] Reducing the number of dimensions with PCA INFO [2024-03-09 21:50:13] Keeping 36 components from initial PCA, explaining 95.31 % of variation. The limit can be changed with `reduce_dimensions.limit` INFO [2024-03-09 21:50:13] -> Finished the reduction of dimensions! WARN [2024-03-09 21:50:13] Keeping 20 of 36 components. Change `max_PC` if necessary. INFO [2024-03-09 21:50:14] Starting validation: bootstrap INFO [2024-03-09 21:50:14] - Run 1 of 100 INFO [2024-03-09 21:50:18] --- Used 4.63 seconds. Est. time remaining: 462.58 seconds INFO [2024-03-09 21:50:18] - Run 2 of 100 INFO [2024-03-09 21:50:22] --- Used 3.69 seconds. Est. time remaining: 409.57 seconds INFO [2024-03-09 21:50:22] - Run 3 of 100 INFO [2024-03-09 21:50:26] --- Used 3.8 seconds. Est. time remaining: 393.24 seconds INFO [2024-03-09 21:50:26] - Run 4 of 100 INFO [2024-03-09 21:50:30] --- Used 3.76 seconds. Est. time remaining: 382.1 seconds INFO [2024-03-09 21:50:30] - Run 5 of 100 INFO [2024-03-09 21:50:33] --- Used 3.79 seconds. Est. time remaining: 374.49 seconds INFO [2024-03-09 21:50:33] - Run 6 of 100 INFO [2024-03-09 21:50:37] --- Used 3.74 seconds. Est. time remaining: 367.47 seconds INFO [2024-03-09 21:50:37] - Run 7 of 100 INFO [2024-03-09 21:50:41] --- Used 3.75 seconds. Est. time remaining: 361.39 seconds INFO [2024-03-09 21:50:41] - Run 8 of 100 INFO [2024-03-09 21:50:45] --- Used 3.89 seconds. Est. time remaining: 357.59 seconds INFO [2024-03-09 21:50:45] - Run 9 of 100 INFO [2024-03-09 21:50:49] --- Used 4.2 seconds. Est. time remaining: 356.87 seconds INFO [2024-03-09 21:50:49] - Run 10 of 100 INFO [2024-03-09 21:50:53] --- Used 3.87 seconds. Est. time remaining: 352.49 seconds INFO [2024-03-09 21:50:53] - Run 11 of 100 INFO [2024-03-09 21:50:57] --- Used 3.87 seconds. Est. time remaining: 348.2 seconds INFO [2024-03-09 21:50:57] - Run 12 of 100 INFO [2024-03-09 21:51:01] --- Used 3.84 seconds. Est. time remaining: 343.78 seconds INFO [2024-03-09 21:51:01] - Run 13 of 100 INFO [2024-03-09 21:51:05] --- Used 3.99 seconds. Est. time remaining: 340.44 seconds INFO [2024-03-09 21:51:05] - Run 14 of 100 INFO [2024-03-09 21:51:08] --- Used 3.87 seconds. Est. time remaining: 336.27 seconds INFO [2024-03-09 21:51:08] - Run 15 of 100 INFO [2024-03-09 21:51:12] --- Used 3.91 seconds. Est. time remaining: 332.35 seconds INFO [2024-03-09 21:51:12] - Run 16 of 100 INFO [2024-03-09 21:51:16] --- Used 3.84 seconds. Est. time remaining: 328.08 seconds INFO [2024-03-09 21:51:16] - Run 17 of 100 INFO [2024-03-09 21:51:20] --- Used 3.84 seconds. Est. time remaining: 323.84 seconds INFO [2024-03-09 21:51:20] - Run 18 of 100 INFO [2024-03-09 21:51:24] --- Used 3.82 seconds. Est. time remaining: 319.56 seconds INFO [2024-03-09 21:51:24] - Run 19 of 100 INFO [2024-03-09 21:51:28] --- Used 3.93 seconds. Est. time remaining: 315.79 seconds INFO [2024-03-09 21:51:28] - Run 20 of 100 INFO [2024-03-09 21:51:32] --- Used 3.86 seconds. Est. time remaining: 311.75 seconds INFO [2024-03-09 21:51:32] - Run 21 of 100 INFO [2024-03-09 21:51:36] --- Used 3.89 seconds. Est. time remaining: 307.81 seconds INFO [2024-03-09 21:51:36] - Run 22 of 100 INFO [2024-03-09 21:51:39] --- Used 3.82 seconds. Est. time remaining: 303.63 seconds INFO [2024-03-09 21:51:39] - Run 23 of 100 INFO [2024-03-09 21:51:43] --- Used 3.85 seconds. Est. time remaining: 299.6 seconds INFO [2024-03-09 21:51:43] - Run 24 of 100 INFO [2024-03-09 21:51:47] --- Used 3.95 seconds. Est. time remaining: 295.89 seconds INFO [2024-03-09 21:51:47] - Run 25 of 100 INFO [2024-03-09 21:51:51] --- Used 3.94 seconds. Est. time remaining: 292.15 seconds INFO [2024-03-09 21:51:51] - Run 26 of 100 INFO [2024-03-09 21:51:55] --- Used 3.91 seconds. Est. time remaining: 288.28 seconds INFO [2024-03-09 21:51:55] - Run 27 of 100 INFO [2024-03-09 21:51:59] --- Used 3.94 seconds. Est. time remaining: 284.52 seconds INFO [2024-03-09 21:51:59] - Run 28 of 100 INFO [2024-03-09 21:52:03] --- Used 3.83 seconds. Est. time remaining: 280.44 seconds INFO [2024-03-09 21:52:03] - Run 29 of 100 INFO [2024-03-09 21:52:07] --- Used 3.94 seconds. Est. time remaining: 276.65 seconds INFO [2024-03-09 21:52:07] - Run 30 of 100 INFO [2024-03-09 21:52:11] --- Used 3.98 seconds. Est. time remaining: 272.95 seconds INFO [2024-03-09 21:52:11] - Run 31 of 100 INFO [2024-03-09 21:52:15] --- Used 3.85 seconds. Est. time remaining: 268.94 seconds INFO [2024-03-09 21:52:15] - Run 32 of 100 INFO [2024-03-09 21:52:18] --- Used 3.74 seconds. Est. time remaining: 264.7 seconds INFO [2024-03-09 21:52:18] - Run 33 of 100 INFO [2024-03-09 21:52:22] --- Used 3.78 seconds. Est. time remaining: 260.57 seconds INFO [2024-03-09 21:52:22] - Run 34 of 100 INFO [2024-03-09 21:52:27] --- Used 4.47 seconds. Est. time remaining: 257.82 seconds INFO [2024-03-09 21:52:27] - Run 35 of 100 INFO [2024-03-09 21:52:30] --- Used 3.84 seconds. Est. time remaining: 253.78 seconds INFO [2024-03-09 21:52:30] - Run 36 of 100 INFO [2024-03-09 21:52:34] --- Used 3.84 seconds. Est. time remaining: 249.77 seconds INFO [2024-03-09 21:52:34] - Run 37 of 100 INFO [2024-03-09 21:52:38] --- Used 3.71 seconds. Est. time remaining: 245.53 seconds INFO [2024-03-09 21:52:38] - Run 38 of 100 INFO [2024-03-09 21:52:42] --- Used 3.82 seconds. Est. time remaining: 241.51 seconds INFO [2024-03-09 21:52:42] - Run 39 of 100 INFO [2024-03-09 21:52:45] --- Used 3.68 seconds. Est. time remaining: 237.28 seconds INFO [2024-03-09 21:52:45] - Run 40 of 100 INFO [2024-03-09 21:52:49] --- Used 3.73 seconds. Est. time remaining: 233.15 seconds INFO [2024-03-09 21:52:49] - Run 41 of 100 INFO [2024-03-09 21:52:53] --- Used 3.78 seconds. Est. time remaining: 229.12 seconds INFO [2024-03-09 21:52:53] - Run 42 of 100 INFO [2024-03-09 21:52:57] --- Used 3.74 seconds. Est. time remaining: 225.04 seconds INFO [2024-03-09 21:52:57] - Run 43 of 100 INFO [2024-03-09 21:53:00] --- Used 3.71 seconds. Est. time remaining: 220.93 seconds INFO [2024-03-09 21:53:00] - Run 44 of 100 INFO [2024-03-09 21:53:04] --- Used 3.75 seconds. Est. time remaining: 216.89 seconds INFO [2024-03-09 21:53:04] - Run 45 of 100 INFO [2024-03-09 21:53:08] --- Used 3.79 seconds. Est. time remaining: 212.91 seconds INFO [2024-03-09 21:53:08] - Run 46 of 100 INFO [2024-03-09 21:53:12] --- Used 3.7 seconds. Est. time remaining: 208.84 seconds INFO [2024-03-09 21:53:12] - Run 47 of 100 INFO [2024-03-09 21:53:16] --- Used 4 seconds. Est. time remaining: 205.12 seconds INFO [2024-03-09 21:53:16] - Run 48 of 100 INFO [2024-03-09 21:53:19] --- Used 3.76 seconds. Est. time remaining: 201.13 seconds INFO [2024-03-09 21:53:19] - Run 49 of 100 INFO [2024-03-09 21:53:23] --- Used 3.78 seconds. Est. time remaining: 197.17 seconds INFO [2024-03-09 21:53:23] - Run 50 of 100 INFO [2024-03-09 21:53:27] --- Used 3.62 seconds. Est. time remaining: 193.06 seconds INFO [2024-03-09 21:53:27] - Run 51 of 100 INFO [2024-03-09 21:53:31] --- Used 3.83 seconds. Est. time remaining: 189.16 seconds INFO [2024-03-09 21:53:31] - Run 52 of 100 INFO [2024-03-09 21:53:34] --- Used 3.77 seconds. Est. time remaining: 185.22 seconds INFO [2024-03-09 21:53:34] - Run 53 of 100 INFO [2024-03-09 21:53:38] --- Used 3.76 seconds. Est. time remaining: 181.28 seconds INFO [2024-03-09 21:53:38] - Run 54 of 100 INFO [2024-03-09 21:53:42] --- Used 3.76 seconds. Est. time remaining: 177.34 seconds INFO [2024-03-09 21:53:42] - Run 55 of 100 INFO [2024-03-09 21:53:46] --- Used 3.73 seconds. Est. time remaining: 173.38 seconds INFO [2024-03-09 21:53:46] - Run 56 of 100 INFO [2024-03-09 21:53:49] --- Used 3.75 seconds. Est. time remaining: 169.45 seconds INFO [2024-03-09 21:53:49] - Run 57 of 100 INFO [2024-03-09 21:53:53] --- Used 3.72 seconds. Est. time remaining: 165.5 seconds INFO [2024-03-09 21:53:53] - Run 58 of 100 INFO [2024-03-09 21:53:57] --- Used 3.96 seconds. Est. time remaining: 161.73 seconds INFO [2024-03-09 21:53:57] - Run 59 of 100 INFO [2024-03-09 21:54:01] --- Used 3.81 seconds. Est. time remaining: 157.85 seconds INFO [2024-03-09 21:54:01] - Run 60 of 100 INFO [2024-03-09 21:54:05] --- Used 3.79 seconds. Est. time remaining: 153.96 seconds INFO [2024-03-09 21:54:05] - Run 61 of 100 INFO [2024-03-09 21:54:08] --- Used 3.7 seconds. Est. time remaining: 150.02 seconds INFO [2024-03-09 21:54:08] - Run 62 of 100 INFO [2024-03-09 21:54:12] --- Used 3.76 seconds. Est. time remaining: 146.12 seconds INFO [2024-03-09 21:54:12] - Run 63 of 100 INFO [2024-03-09 21:54:16] --- Used 3.73 seconds. Est. time remaining: 142.21 seconds INFO [2024-03-09 21:54:16] - Run 64 of 100 INFO [2024-03-09 21:54:20] --- Used 3.8 seconds. Est. time remaining: 138.34 seconds INFO [2024-03-09 21:54:20] - Run 65 of 100 INFO [2024-03-09 21:54:23] --- Used 3.74 seconds. Est. time remaining: 134.44 seconds INFO [2024-03-09 21:54:23] - Run 66 of 100 INFO [2024-03-09 21:54:27] --- Used 3.74 seconds. Est. time remaining: 130.55 seconds INFO [2024-03-09 21:54:27] - Run 67 of 100 INFO [2024-03-09 21:54:31] --- Used 3.79 seconds. Est. time remaining: 126.68 seconds INFO [2024-03-09 21:54:31] - Run 68 of 100 INFO [2024-03-09 21:54:35] --- Used 3.82 seconds. Est. time remaining: 122.83 seconds INFO [2024-03-09 21:54:35] - Run 69 of 100 INFO [2024-03-09 21:54:39] --- Used 3.82 seconds. Est. time remaining: 118.99 seconds INFO [2024-03-09 21:54:39] - Run 70 of 100 INFO [2024-03-09 21:54:42] --- Used 3.82 seconds. Est. time remaining: 115.14 seconds INFO [2024-03-09 21:54:42] - Run 71 of 100 INFO [2024-03-09 21:54:46] --- Used 3.92 seconds. Est. time remaining: 111.34 seconds INFO [2024-03-09 21:54:46] - Run 72 of 100 INFO [2024-03-09 21:54:50] --- Used 3.84 seconds. Est. time remaining: 107.5 seconds INFO [2024-03-09 21:54:50] - Run 73 of 100 INFO [2024-03-09 21:54:54] --- Used 3.76 seconds. Est. time remaining: 103.63 seconds INFO [2024-03-09 21:54:54] - Run 74 of 100 INFO [2024-03-09 21:54:58] --- Used 3.82 seconds. Est. time remaining: 99.79 seconds INFO [2024-03-09 21:54:58] - Run 75 of 100 INFO [2024-03-09 21:55:02] --- Used 3.8 seconds. Est. time remaining: 95.94 seconds INFO [2024-03-09 21:55:02] - Run 76 of 100 INFO [2024-03-09 21:55:05] --- Used 3.84 seconds. Est. time remaining: 92.1 seconds INFO [2024-03-09 21:55:05] - Run 77 of 100 INFO [2024-03-09 21:55:09] --- Used 3.76 seconds. Est. time remaining: 88.24 seconds INFO [2024-03-09 21:55:09] - Run 78 of 100 INFO [2024-03-09 21:55:14] --- Used 4.53 seconds. Est. time remaining: 84.6 seconds INFO [2024-03-09 21:55:14] - Run 79 of 100 INFO [2024-03-09 21:55:17] --- Used 3.77 seconds. Est. time remaining: 80.73 seconds INFO [2024-03-09 21:55:17] - Run 80 of 100 INFO [2024-03-09 21:55:21] --- Used 3.69 seconds. Est. time remaining: 76.85 seconds INFO [2024-03-09 21:55:21] - Run 81 of 100 INFO [2024-03-09 21:55:25] --- Used 3.78 seconds. Est. time remaining: 72.99 seconds INFO [2024-03-09 21:55:25] - Run 82 of 100 INFO [2024-03-09 21:55:29] --- Used 3.79 seconds. Est. time remaining: 69.14 seconds INFO [2024-03-09 21:55:29] - Run 83 of 100 INFO [2024-03-09 21:55:32] --- Used 3.73 seconds. Est. time remaining: 65.27 seconds INFO [2024-03-09 21:55:32] - Run 84 of 100 INFO [2024-03-09 21:55:36] --- Used 3.79 seconds. Est. time remaining: 61.43 seconds INFO [2024-03-09 21:55:36] - Run 85 of 100 INFO [2024-03-09 21:55:40] --- Used 3.8 seconds. Est. time remaining: 57.58 seconds INFO [2024-03-09 21:55:40] - Run 86 of 100 INFO [2024-03-09 21:55:44] --- Used 3.74 seconds. Est. time remaining: 53.73 seconds INFO [2024-03-09 21:55:44] - Run 87 of 100 INFO [2024-03-09 21:55:47] --- Used 3.72 seconds. Est. time remaining: 49.87 seconds INFO [2024-03-09 21:55:47] - Run 88 of 100 INFO [2024-03-09 21:55:51] --- Used 3.78 seconds. Est. time remaining: 46.03 seconds INFO [2024-03-09 21:55:51] - Run 89 of 100 INFO [2024-03-09 21:55:55] --- Used 3.91 seconds. Est. time remaining: 42.2 seconds INFO [2024-03-09 21:55:55] - Run 90 of 100 INFO [2024-03-09 21:55:59] --- Used 3.8 seconds. Est. time remaining: 38.36 seconds INFO [2024-03-09 21:55:59] - Run 91 of 100 INFO [2024-03-09 21:56:03] --- Used 3.92 seconds. Est. time remaining: 34.53 seconds INFO [2024-03-09 21:56:03] - Run 92 of 100 INFO [2024-03-09 21:56:07] --- Used 3.83 seconds. Est. time remaining: 30.69 seconds INFO [2024-03-09 21:56:07] - Run 93 of 100 INFO [2024-03-09 21:56:10] --- Used 3.69 seconds. Est. time remaining: 26.85 seconds INFO [2024-03-09 21:56:10] - Run 94 of 100 INFO [2024-03-09 21:56:14] --- Used 3.83 seconds. Est. time remaining: 23.01 seconds INFO [2024-03-09 21:56:14] - Run 95 of 100 INFO [2024-03-09 21:56:18] --- Used 3.84 seconds. Est. time remaining: 19.18 seconds INFO [2024-03-09 21:56:18] - Run 96 of 100 INFO [2024-03-09 21:56:22] --- Used 3.86 seconds. Est. time remaining: 15.34 seconds INFO [2024-03-09 21:56:22] - Run 97 of 100 INFO [2024-03-09 21:56:26] --- Used 3.73 seconds. Est. time remaining: 11.5 seconds INFO [2024-03-09 21:56:26] - Run 98 of 100 INFO [2024-03-09 21:56:29] --- Used 3.73 seconds. Est. time remaining: 7.67 seconds INFO [2024-03-09 21:56:29] - Run 99 of 100 INFO [2024-03-09 21:56:33] --- Used 3.78 seconds. Est. time remaining: 3.83 seconds INFO [2024-03-09 21:56:33] - Run 100 of 100 INFO [2024-03-09 21:56:37] --- Used 3.87 seconds. Est. time remaining: 0 seconds INFO [2024-03-09 21:56:37] Calculating percentiles for score and loading INFO [2024-03-09 21:57:03] ==== ALASCA has finished ==== INFO [2024-03-09 21:57:03] To visualize the model, try `plot(, effect = 1, component = 1, type = 'effect')` INFO [2024-03-09 21:57:03] Scree plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 1 and 2 and 3 and 4 and 5 and 6 and 7 and 8 and 9 and 10. INFO [2024-03-09 21:57:03] Effect plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 1. WARN [2024-03-09 21:57:03] Showing 20 of 12641 variables. Adjust the number with `n_limit` INFO [2024-03-09 21:57:04] Effect plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 2. WARN [2024-03-09 21:57:04] Showing 20 of 12641 variables. Adjust the number with `n_limit` INFO [2024-03-09 21:57:05] Effect plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 3. WARN [2024-03-09 21:57:05] Showing 20 of 12641 variables. Adjust the number with `n_limit` INFO [2024-03-09 21:57:05] Effect plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 4. WARN [2024-03-09 21:57:06] Showing 20 of 12641 variables. Adjust the number with `n_limit` INFO [2024-03-09 21:57:06] Effect plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 5. WARN [2024-03-09 21:57:06] Showing 20 of 12641 variables. Adjust the number with `n_limit` INFO [2024-03-09 21:57:07] Effect plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 6. WARN [2024-03-09 21:57:07] Showing 20 of 12641 variables. Adjust the number with `n_limit` INFO [2024-03-09 21:57:08] Scores for effect number 1 and principal component(s) 6 INFO [2024-03-09 21:57:08] Prediction plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 1. INFO [2024-03-09 21:57:08] Selecting the 10 variables with highest/lowest loading on `fold+fold:treatment+treatment` (PC1). Use `variable` to specify variables to plot INFO [2024-03-09 21:57:10] Prediction plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 2. INFO [2024-03-09 21:57:10] Selecting the 10 variables with highest/lowest loading on `fold+fold:treatment+treatment` (PC2). Use `variable` to specify variables to plot INFO [2024-03-09 21:57:12] Prediction plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 3. INFO [2024-03-09 21:57:12] Selecting the 10 variables with highest/lowest loading on `fold+fold:treatment+treatment` (PC3). Use `variable` to specify variables to plot INFO [2024-03-09 21:57:13] Prediction plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 4. INFO [2024-03-09 21:57:13] Selecting the 10 variables with highest/lowest loading on `fold+fold:treatment+treatment` (PC4). Use `variable` to specify variables to plot INFO [2024-03-09 21:57:15] Prediction plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 5. INFO [2024-03-09 21:57:15] Selecting the 10 variables with highest/lowest loading on `fold+fold:treatment+treatment` (PC5). Use `variable` to specify variables to plot INFO [2024-03-09 21:57:16] Prediction plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 6. INFO [2024-03-09 21:57:16] Selecting the 10 variables with highest/lowest loading on `fold+fold:treatment+treatment` (PC6). Use `variable` to specify variables to plot INFO [2024-03-09 21:57:18] Loadings for effect number 1 and principal component(s) 5 INFO [2024-03-09 21:57:18] Loadings for effect number 1 and principal component(s) 6 INFO [2024-03-09 21:57:18] Loadings for effect number 1 and principal component(s) 1 INFO [2024-03-09 21:57:18] Loadings for effect number 1 and principal component(s) 2 INFO [2024-03-09 21:57:18] Loadings for effect number 1 and principal component(s) 3 INFO [2024-03-09 21:57:18] Loadings for effect number 1 and principal component(s) 4