INFO [2024-03-09 21:41:11] Initializing ALASCA (v1.0.15, 2024-02-07) WARN [2024-03-09 21:41:11] Guessing effects: `fold+fold:treatment+treatment` INFO [2024-03-09 21:41:11] Will use linear mixed models! INFO [2024-03-09 21:41:11] Will use Rfast! WARN [2024-03-09 21:41:11] Converting IDs to integer values WARN [2024-03-09 21:41:11] The `fold` column is used for stratification WARN [2024-03-09 21:41:11] Converting `character` columns to factors INFO [2024-03-09 21:41:11] Scaling data with sdall ... INFO [2024-03-09 21:41:12] Calculating LMM coefficients INFO [2024-03-09 21:41:12] Reducing the number of dimensions with PCA INFO [2024-03-09 21:41:13] Keeping 46 components from initial PCA, explaining 95.24 % of variation. The limit can be changed with `reduce_dimensions.limit` INFO [2024-03-09 21:41:13] -> Finished the reduction of dimensions! WARN [2024-03-09 21:41:13] Keeping 20 of 46 components. Change `max_PC` if necessary. INFO [2024-03-09 21:41:14] Starting validation: bootstrap INFO [2024-03-09 21:41:14] - Run 1 of 100 INFO [2024-03-09 21:41:18] --- Used 4.38 seconds. Est. time remaining: 435.7 seconds INFO [2024-03-09 21:41:18] - Run 2 of 100 INFO [2024-03-09 21:41:23] --- Used 4.4 seconds. Est. time remaining: 431.24 seconds INFO [2024-03-09 21:41:23] - Run 3 of 100 INFO [2024-03-09 21:41:28] --- Used 5.05 seconds. Est. time remaining: 447.83 seconds INFO [2024-03-09 21:41:28] - Run 4 of 100 INFO [2024-03-09 21:41:32] --- Used 4.2 seconds. Est. time remaining: 433.18 seconds INFO [2024-03-09 21:41:32] - Run 5 of 100 INFO [2024-03-09 21:41:36] --- Used 4.19 seconds. Est. time remaining: 422.47 seconds INFO [2024-03-09 21:41:36] - Run 6 of 100 INFO [2024-03-09 21:41:40] --- Used 4.1 seconds. Est. time remaining: 412.66 seconds INFO [2024-03-09 21:41:40] - Run 7 of 100 INFO [2024-03-09 21:41:44] --- Used 4.13 seconds. Est. time remaining: 404.84 seconds INFO [2024-03-09 21:41:44] - Run 8 of 100 INFO [2024-03-09 21:41:49] --- Used 4.16 seconds. Est. time remaining: 398.21 seconds INFO [2024-03-09 21:41:49] - Run 9 of 100 INFO [2024-03-09 21:41:53] --- Used 4.18 seconds. Est. time remaining: 392.35 seconds INFO [2024-03-09 21:41:53] - Run 10 of 100 INFO [2024-03-09 21:41:57] --- Used 4.15 seconds. Est. time remaining: 386.55 seconds INFO [2024-03-09 21:41:57] - Run 11 of 100 INFO [2024-03-09 21:42:01] --- Used 4.15 seconds. Est. time remaining: 381.06 seconds INFO [2024-03-09 21:42:01] - Run 12 of 100 INFO [2024-03-09 21:42:05] --- Used 4.07 seconds. Est. time remaining: 375.25 seconds INFO [2024-03-09 21:42:05] - Run 13 of 100 INFO [2024-03-09 21:42:09] --- Used 4.2 seconds. Est. time remaining: 370.56 seconds INFO [2024-03-09 21:42:09] - Run 14 of 100 INFO [2024-03-09 21:42:14] --- Used 4.23 seconds. Est. time remaining: 366.12 seconds INFO [2024-03-09 21:42:14] - Run 15 of 100 INFO [2024-03-09 21:42:18] --- Used 4.15 seconds. Est. time remaining: 361.25 seconds INFO [2024-03-09 21:42:18] - Run 16 of 100 INFO [2024-03-09 21:42:22] --- Used 4.42 seconds. Est. time remaining: 357.88 seconds INFO [2024-03-09 21:42:22] - Run 17 of 100 INFO [2024-03-09 21:42:26] --- Used 4.18 seconds. Est. time remaining: 353.21 seconds INFO [2024-03-09 21:42:26] - Run 18 of 100 INFO [2024-03-09 21:42:31] --- Used 4.19 seconds. Est. time remaining: 348.65 seconds INFO [2024-03-09 21:42:31] - Run 19 of 100 INFO [2024-03-09 21:42:35] --- Used 4.32 seconds. Est. time remaining: 344.68 seconds INFO [2024-03-09 21:42:35] - Run 20 of 100 INFO [2024-03-09 21:42:39] --- Used 4.26 seconds. Est. time remaining: 340.42 seconds INFO [2024-03-09 21:42:39] - Run 21 of 100 INFO [2024-03-09 21:42:43] --- Used 4.15 seconds. Est. time remaining: 335.76 seconds INFO [2024-03-09 21:42:43] - Run 22 of 100 INFO [2024-03-09 21:42:47] --- Used 4.16 seconds. Est. time remaining: 331.2 seconds INFO [2024-03-09 21:42:47] - Run 23 of 100 INFO [2024-03-09 21:42:52] --- Used 4.27 seconds. Est. time remaining: 327.04 seconds INFO [2024-03-09 21:42:52] - Run 24 of 100 INFO [2024-03-09 21:42:56] --- Used 4.23 seconds. Est. time remaining: 322.73 seconds INFO [2024-03-09 21:42:56] - Run 25 of 100 INFO [2024-03-09 21:43:00] --- Used 4.22 seconds. Est. time remaining: 318.41 seconds INFO [2024-03-09 21:43:00] - Run 26 of 100 INFO [2024-03-09 21:43:05] --- Used 4.4 seconds. Est. time remaining: 314.62 seconds INFO [2024-03-09 21:43:05] - Run 27 of 100 INFO [2024-03-09 21:43:09] --- Used 4.24 seconds. Est. time remaining: 310.35 seconds INFO [2024-03-09 21:43:09] - Run 28 of 100 INFO [2024-03-09 21:43:13] --- Used 4.18 seconds. Est. time remaining: 305.9 seconds INFO [2024-03-09 21:43:13] - Run 29 of 100 INFO [2024-03-09 21:43:17] --- Used 4.25 seconds. Est. time remaining: 301.66 seconds INFO [2024-03-09 21:43:17] - Run 30 of 100 INFO [2024-03-09 21:43:21] --- Used 4.25 seconds. Est. time remaining: 297.42 seconds INFO [2024-03-09 21:43:21] - Run 31 of 100 INFO [2024-03-09 21:43:26] --- Used 4.27 seconds. Est. time remaining: 293.22 seconds INFO [2024-03-09 21:43:26] - Run 32 of 100 INFO [2024-03-09 21:43:30] --- Used 4.23 seconds. Est. time remaining: 288.94 seconds INFO [2024-03-09 21:43:30] - Run 33 of 100 INFO [2024-03-09 21:43:34] --- Used 4.21 seconds. Est. time remaining: 284.61 seconds INFO [2024-03-09 21:43:34] - Run 34 of 100 INFO [2024-03-09 21:43:38] --- Used 4.26 seconds. Est. time remaining: 280.39 seconds INFO [2024-03-09 21:43:38] - Run 35 of 100 INFO [2024-03-09 21:43:43] --- Used 4.17 seconds. 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Est. time remaining: 216.5 seconds INFO [2024-03-09 21:44:42] - Run 50 of 100 INFO [2024-03-09 21:44:46] --- Used 4.2 seconds. Est. time remaining: 212.22 seconds INFO [2024-03-09 21:44:46] - Run 51 of 100 INFO [2024-03-09 21:44:50] --- Used 4.15 seconds. Est. time remaining: 207.89 seconds INFO [2024-03-09 21:44:50] - Run 52 of 100 INFO [2024-03-09 21:44:55] --- Used 4.21 seconds. Est. time remaining: 203.61 seconds INFO [2024-03-09 21:44:55] - Run 53 of 100 INFO [2024-03-09 21:44:59] --- Used 4.26 seconds. Est. time remaining: 199.39 seconds INFO [2024-03-09 21:44:59] - Run 54 of 100 INFO [2024-03-09 21:45:03] --- Used 4.28 seconds. Est. time remaining: 195.17 seconds INFO [2024-03-09 21:45:03] - Run 55 of 100 INFO [2024-03-09 21:45:07] --- Used 4.13 seconds. Est. time remaining: 190.84 seconds INFO [2024-03-09 21:45:07] - Run 56 of 100 INFO [2024-03-09 21:45:11] --- Used 4.19 seconds. 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Est. time remaining: 8.52 seconds INFO [2024-03-09 21:48:11] - Run 99 of 100 INFO [2024-03-09 21:48:16] --- Used 4.23 seconds. Est. time remaining: 4.26 seconds INFO [2024-03-09 21:48:16] - Run 100 of 100 INFO [2024-03-09 21:48:20] --- Used 4.26 seconds. Est. time remaining: 0 seconds INFO [2024-03-09 21:48:20] Calculating percentiles for score and loading INFO [2024-03-09 21:48:43] ==== ALASCA has finished ==== INFO [2024-03-09 21:48:43] To visualize the model, try `plot(, effect = 1, component = 1, type = 'effect')` INFO [2024-03-09 21:48:43] Scree plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 1 and 2 and 3 and 4 and 5 and 6 and 7 and 8 and 9 and 10. INFO [2024-03-09 21:48:43] Effect plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 1. WARN [2024-03-09 21:48:43] Showing 20 of 11270 variables. Adjust the number with `n_limit` INFO [2024-03-09 21:48:44] Effect plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 2. WARN [2024-03-09 21:48:44] Showing 20 of 11270 variables. Adjust the number with `n_limit` INFO [2024-03-09 21:48:45] Effect plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 3. WARN [2024-03-09 21:48:45] Showing 20 of 11270 variables. Adjust the number with `n_limit` INFO [2024-03-09 21:48:45] Effect plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 4. WARN [2024-03-09 21:48:45] Showing 20 of 11270 variables. Adjust the number with `n_limit` INFO [2024-03-09 21:48:46] Effect plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 5. WARN [2024-03-09 21:48:46] Showing 20 of 11270 variables. Adjust the number with `n_limit` INFO [2024-03-09 21:48:47] Effect plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 6. WARN [2024-03-09 21:48:47] Showing 20 of 11270 variables. Adjust the number with `n_limit` INFO [2024-03-09 21:48:48] Prediction plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 1. INFO [2024-03-09 21:48:48] Selecting the 10 variables with highest/lowest loading on `fold+fold:treatment+treatment` (PC1). Use `variable` to specify variables to plot INFO [2024-03-09 21:48:50] Prediction plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 2. INFO [2024-03-09 21:48:50] Selecting the 10 variables with highest/lowest loading on `fold+fold:treatment+treatment` (PC2). Use `variable` to specify variables to plot INFO [2024-03-09 21:48:51] Prediction plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 3. INFO [2024-03-09 21:48:51] Selecting the 10 variables with highest/lowest loading on `fold+fold:treatment+treatment` (PC3). Use `variable` to specify variables to plot INFO [2024-03-09 21:48:53] Prediction plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 4. INFO [2024-03-09 21:48:53] Selecting the 10 variables with highest/lowest loading on `fold+fold:treatment+treatment` (PC4). Use `variable` to specify variables to plot INFO [2024-03-09 21:48:54] Prediction plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 5. INFO [2024-03-09 21:48:54] Selecting the 10 variables with highest/lowest loading on `fold+fold:treatment+treatment` (PC5). Use `variable` to specify variables to plot INFO [2024-03-09 21:48:56] Prediction plot. Selected effect (nr 1): `fold+fold:treatment+treatment`. Component: 6. INFO [2024-03-09 21:48:56] Selecting the 10 variables with highest/lowest loading on `fold+fold:treatment+treatment` (PC6). Use `variable` to specify variables to plot INFO [2024-03-09 21:48:58] Loadings for effect number 1 and principal component(s) 5 INFO [2024-03-09 21:48:58] Loadings for effect number 1 and principal component(s) 6 INFO [2024-03-09 21:48:58] Loadings for effect number 1 and principal component(s) 1 INFO [2024-03-09 21:48:58] Loadings for effect number 1 and principal component(s) 2 INFO [2024-03-09 21:48:58] Loadings for effect number 1 and principal component(s) 3 INFO [2024-03-09 21:48:58] Loadings for effect number 1 and principal component(s) 4