gene_id	mrna_id	accession	pident	aln_len	qlen	slen	evalue	bitscore	entry_name	protein_name	organism	go_bp	go_mf	go_cc	go_ids
GN000014	GN000014.1	Q22795	36.2	141	206	242	1.15e-22	94.7	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000016	GN000016.1	Q22795	35.0	117	501	242	2.31e-16	82.0	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000017	GN000017.1	Q22795	35.9	117	619	242	2.36e-16	82.4	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000019	GN000019.1	Q22795	36.2	141	470	242	3.01e-21	95.9	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000021	GN000021.1	Q22795	36.2	141	470	242	5.63e-21	95.1	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000023	GN000023.1	Q22795	35.0	117	451	242	1.87e-16	82.0	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000025	GN000025.1	Q22795	36.2	141	537	242	4.31e-21	95.9	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000034	GN000034.1	Q22795	44.9	69	101	242	3.56e-10	57.8	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000036	GN000036.1	Q22795	35.5	141	552	242	2.08e-18	88.2	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000039	GN000039.1	Q22795	36.2	141	162	242	6.57e-22	91.3	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000040	GN000040.1	Q22795	35.5	141	552	242	2.08e-18	88.2	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000043	GN000043.1	Q22795	36.9	141	162	242	2.23e-23	95.1	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000045	GN000045.1	Q22795	35.9	117	143	242	2.30e-18	81.3	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000048	GN000048.1	Q22795	35.9	117	143	242	2.30e-18	81.3	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000049	GN000049.1	Q22795	35.0	117	511	242	6.74e-15	77.8	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000052	GN000052.1	Q22795	35.9	117	143	242	2.30e-18	81.3	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000053	GN000053.1	Q22795	36.9	141	507	242	2.75e-21	96.3	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000054	GN000054.1	Q22795	36.2	141	521	242	6.44e-20	92.4	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000055	GN000055.1	Q22795	36.2	141	479	242	7.15e-20	92.0	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000057	GN000057.1	Q22795	36.2	141	597	242	1.12e-19	92.0	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000064	GN000064.1	Q22795	36.9	141	438	242	9.16e-22	97.1	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000066	GN000066.1	Q22795	36.2	141	162	242	1.29e-21	90.5	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000069	GN000069.1	Q22795	35.5	141	687	242	6.49e-21	95.9	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000070	GN000070.1	Q22795	36.9	141	575	242	3.63e-21	96.3	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000076	GN000076.1	Q22795	36.2	141	218	242	2.31e-21	91.7	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000078	GN000078.1	Q22795	34.8	141	796	242	1.39e-18	89.4	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000082	GN000082.1	Q22795	36.2	141	347	242	4.29e-22	96.7	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN000086	GN000086.1	Q6R7G0	20.3	518	623	693	5.10e-13	75.9	Y068_OSHVF	Putative transmembrane protein ORF68	Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)			host cell membrane [GO:0033644]	GO:0033644
GN000091	GN000091.1	Q8CGQ8	42.0	541	580	622	3.89e-116	361	NCKX4_MOUSE	Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4)	Mus musculus (Mouse)	amelogenesis [GO:0097186]; calcium ion export across plasma membrane [GO:1990034]; calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to high light intensity [GO:0071486]; cone photoresponse recovery [GO:0036368]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; drinking behavior [GO:0042756]; intracellular calcium ion homeostasis [GO:0006874]; membrane repolarization [GO:0086009]; negative regulation of calcium-mediated signaling [GO:0050849]; olfactory nerve maturation [GO:0021630]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; potassium ion transmembrane transport [GO:0071805]; regulation of eating behavior [GO:1903998]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to melanocyte-stimulating hormone [GO:1990680]; response to odorant [GO:1990834]; sensory perception of smell [GO:0007608]; sodium ion transmembrane transport [GO:0035725]	calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; calcium-dependent protein binding [GO:0048306]; calcium:sodium antiporter activity [GO:0005432]; calmodulin binding [GO:0005516]	apical plasma membrane [GO:0016324]; cone photoreceptor outer segment [GO:0120199]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GO:0005262; GO:0005432; GO:0005516; GO:0005737; GO:0005886; GO:0006874; GO:0007602; GO:0007608; GO:0008273; GO:0008277; GO:0010628; GO:0016020; GO:0016324; GO:0021630; GO:0031982; GO:0035725; GO:0036368; GO:0042756; GO:0048306; GO:0050849; GO:0050911; GO:0055074; GO:0070588; GO:0071486; GO:0071805; GO:0086009; GO:0097186; GO:0098703; GO:0120199; GO:1903998; GO:1990034; GO:1990680; GO:1990834
GN000092	GN000092.1	F1NWE3	34.6	104	113	1516	3.58e-12	64.7	PTPRS_CHICK	Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Chick receptor tyrosine phosphatase alpha) (CRYP alpha) (CRYPalpha)	Gallus gallus (Chicken)	negative regulation of axon extension [GO:0030517]; negative regulation of axon regeneration [GO:0048681]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendritic spine development [GO:0061000]; peptidyl-tyrosine dephosphorylation [GO:0035335]; signal transduction [GO:0007165]; synaptic membrane adhesion [GO:0099560]	heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity [GO:0004725]	axon [GO:0030424]; growth cone [GO:0030426]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; synaptic vesicle membrane [GO:0030672]	GO:0004725; GO:0005886; GO:0007165; GO:0008201; GO:0014069; GO:0030424; GO:0030426; GO:0030517; GO:0030672; GO:0035335; GO:0042803; GO:0043204; GO:0043395; GO:0048671; GO:0048681; GO:0061000; GO:0098839; GO:0099560
GN000095	GN000095.1	P22274	44.4	153	184	179	3.55e-45	150	ARF_CANAL	ADP-ribosylation factor	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)	cellular response to reactive oxygen species [GO:0034614]; intracellular protein transport [GO:0006886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	GO:0003924; GO:0005525; GO:0005794; GO:0005886; GO:0006886; GO:0034614
GN000109	GN000109.1	Q5F389	61.2	49	90	414	1.52e-10	58.9	WWOX_CHICK	WW domain-containing oxidoreductase (EC 1.1.1.-)	Gallus gallus (Chicken)	cellular response to transforming growth factor beta stimulus [GO:0071560]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of transcription by RNA polymerase II [GO:0045944]	enzyme binding [GO:0019899]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; microvillus [GO:0005902]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0003713; GO:0005654; GO:0005737; GO:0005739; GO:0005764; GO:0005794; GO:0005829; GO:0005886; GO:0005902; GO:0019899; GO:0030178; GO:0045944; GO:0071560; GO:0090575; GO:2001238
GN000134	GN000134.1	Q8N5I4	35.1	305	441	330	1.17e-41	153	DHRSX_HUMAN	Polyprenol dehydrogenase (EC 1.1.1.441) (DHRSXY) (Dehydrogenase/reductase SDR family member on chromosome X) (Dolichal reductase)	Homo sapiens (Human)	dolichyl monophosphate biosynthetic process [GO:0043048]; positive regulation of autophagy [GO:0010508]	alcohol dehydrogenase (NADP+) activity [GO:0008106]; dolichal reductase (NADPH) activity [GO:0160197]; polyprenol dehydrogenase (NAD+) activity [GO:0160196]	endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]	GO:0005576; GO:0005789; GO:0005811; GO:0008106; GO:0010508; GO:0043048; GO:0160196; GO:0160197
GN000136	GN000136.1	Q9U221	56.4	225	277	282	2.02e-87	265	UNG_CAEEL	Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)	Caenorhabditis elegans	base-excision repair [GO:0006284]; base-excision repair, AP site formation via deaminated base removal [GO:0097510]	uracil DNA N-glycosylase activity [GO:0004844]	mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0004844; GO:0005634; GO:0005739; GO:0006284; GO:0097510
GN000137	GN000137.1	Q96ME1	26.7	688	762	718	1.56e-46	180	FXL18_HUMAN	F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18)	Homo sapiens (Human)	regulation of apoptotic process [GO:0042981]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]		cytosol [GO:0005829]	GO:0005829; GO:0031146; GO:0042981
GN000145	GN000145.1	P06276	34.3	591	2739	602	1.22e-81	286	CHLE_HUMAN	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	Homo sapiens (Human)	acetylcholine catabolic process [GO:0006581]; choline metabolic process [GO:0019695]; cocaine catabolic process [GO:0050784]; learning [GO:0007612]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of synaptic transmission [GO:0050805]; neuroblast differentiation [GO:0014016]; peptide hormone processing [GO:0016486]; response to alkaloid [GO:0043279]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384]; xenobiotic metabolic process [GO:0006805]	acetylcholinesterase activity [GO:0003990]; amyloid-beta binding [GO:0001540]; catalytic activity [GO:0003824]; choline binding [GO:0033265]; cholinesterase activity [GO:0004104]; enzyme binding [GO:0019899]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]	blood microparticle [GO:0072562]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; nuclear envelope lumen [GO:0005641]; plasma membrane [GO:0005886]	GO:0001540; GO:0003824; GO:0003990; GO:0004104; GO:0005576; GO:0005641; GO:0005788; GO:0005886; GO:0006581; GO:0006805; GO:0007612; GO:0008285; GO:0014016; GO:0016486; GO:0016788; GO:0019695; GO:0019899; GO:0033265; GO:0042802; GO:0043279; GO:0050784; GO:0050805; GO:0051384; GO:0051593; GO:0072562
GN000147	GN000147.1	Q96MB7	37.9	232	270	349	1.02e-53	180	HARB1_HUMAN	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Homo sapiens (Human)			cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005829; GO:0005886
GN000155	GN000155.1	P02637	37.2	78	311	176	1.54e-09	59.7	SCP_MIZYE	Sarcoplasmic calcium-binding protein (SCP)	Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis)		calcium ion binding [GO:0005509]		GO:0005509
GN000159	GN000159.1	D3YZI9	32.2	121	251	523	6.73e-09	59.3	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN000165	GN000165.1	Q63118	36.0	364	449	464	6.97e-62	211	CALRL_RAT	Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)	Rattus norvegicus (Rat)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; angiogenesis [GO:0001525]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to sucrose stimulus [GO:0071329]; heart development [GO:0007507]; negative regulation of smooth muscle contraction [GO:0045986]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein transport [GO:0015031]; receptor internalization [GO:0031623]	adrenomedullin binding [GO:1990409]; adrenomedullin receptor activity [GO:0001605]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948]	adrenomedullin receptor complex [GO:1903143]; CGRP receptor complex [GO:1990406]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; lysosome [GO:0005764]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GO:0001525; GO:0001605; GO:0001635; GO:0004948; GO:0005737; GO:0005764; GO:0005768; GO:0005783; GO:0005886; GO:0006816; GO:0007166; GO:0007189; GO:0007507; GO:0008021; GO:0008284; GO:0015031; GO:0031623; GO:0045986; GO:0048661; GO:0071329; GO:0098992; GO:1903143; GO:1990406; GO:1990408; GO:1990409; GO:1990410
GN000166	GN000166.1	Q99KJ8	47.3	404	400	402	1.93e-107	325	DCTN2_MOUSE	Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (Growth cone membrane protein 23-48K) (GMP23-48K) (p50 dynamitin)	Mus musculus (Mouse)	melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]; protein localization to centrosome [GO:0071539]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; spectrin binding [GO:0030507]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; dynactin complex [GO:0005869]; growth cone [GO:0030426]; kinetochore [GO:0000776]; membrane [GO:0016020]; vesicle [GO:0031982]	GO:0000776; GO:0005737; GO:0005813; GO:0005869; GO:0007052; GO:0007080; GO:0016020; GO:0019901; GO:0030426; GO:0030507; GO:0031982; GO:0032402; GO:0036064; GO:0042802; GO:0071539
GN000167	GN000167.1	O16374	26.4	364	587	425	2.01e-26	115	GALT1_CAEEL	Beta-1,4-galactosyltransferase galt-1 (EC 2.4.1.-)	Caenorhabditis elegans	carbohydrate derivative biosynthetic process [GO:1901137]; N-glycan processing [GO:0006491]	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; UDP-galactosyltransferase activity [GO:0035250]	Golgi cisterna membrane [GO:0032580]	GO:0003831; GO:0006491; GO:0032580; GO:0035250; GO:1901137
GN000169	GN000169.1	P10867	23.3	494	606	440	3.78e-19	94.0	GGLO_RAT	L-gulonolactone oxidase (LGO) (EC 1.1.3.8) (L-gulono-gamma-lactone oxidase) (GLO)	Rattus norvegicus (Rat)	L-ascorbic acid biosynthetic process [GO:0019853]	D-arabinono-1,4-lactone oxidase activity [GO:0003885]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; L-gulonolactone oxidase activity [GO:0050105]	endoplasmic reticulum membrane [GO:0005789]	GO:0003885; GO:0005789; GO:0019853; GO:0050105; GO:0050660; GO:0071949
GN000171	GN000171.1	Q5RLM2	30.5	443	493	535	8.43e-54	192	S22A7_RAT	Solute carrier family 22 member 7 (Novel liver transporter) (Organic anion transporter 2) (rOAT2)	Rattus norvegicus (Rat)	alpha-ketoglutarate transport [GO:0015742]; prostaglandin transport [GO:0015732]; response to stilbenoid [GO:0035634]; sodium-independent organic anion transport [GO:0043252]	alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; prostaglandin transmembrane transporter activity [GO:0015132]; secondary active transmembrane transporter activity [GO:0015291]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005886; GO:0009925; GO:0015132; GO:0015139; GO:0015291; GO:0015732; GO:0015742; GO:0016323; GO:0016324; GO:0022857; GO:0035634; GO:0043252
GN000172	GN000172.1	Q07263	27.4	321	403	495	4.53e-33	132	ACHA3_BOVIN	Neuronal acetylcholine receptor subunit alpha-3	Bos taurus (Bovine)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005783; GO:0005794; GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0035095; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060; GO:0098793; GO:0099171
GN000173	GN000173.1	Q07263	31.2	202	271	495	3.25e-23	101	ACHA3_BOVIN	Neuronal acetylcholine receptor subunit alpha-3	Bos taurus (Bovine)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005783; GO:0005794; GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0035095; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060; GO:0098793; GO:0099171
GN000176	GN000176.1	Q25414	47.7	419	470	509	2.09e-110	338	5HTR_LYMST	5-hydroxytryptamine receptor (5-HT receptor) (Serotonin receptor)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; positive regulation of MAPK cascade [GO:0043410]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0043410; GO:0071880
GN000178	GN000178.1	Q3ULW8	52.5	547	531	533	9.79e-170	493	PARP3_MOUSE	Protein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly [ADP-ribose] polymerase 3) (PARP-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)	Mus musculus (Mouse)	DNA ADP-ribosylation [GO:0030592]; double-strand break repair [GO:0006302]; negative regulation of isotype switching [GO:0045829]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to site of double-strand break [GO:1990166]; regulation of mitotic spindle organization [GO:0060236]; telomere maintenance [GO:0000723]	NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]	centriole [GO:0005814]; centrosome [GO:0005813]; chromosome [GO:0005694]; intercellular bridge [GO:0045171]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000723; GO:0003950; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005813; GO:0005814; GO:0006302; GO:0016604; GO:0030592; GO:0035861; GO:0045171; GO:0045829; GO:0060236; GO:0070213; GO:0140294; GO:0140804; GO:0140806; GO:0140807; GO:1990166; GO:1990404; GO:2001034
GN000179	GN000179.1	Q3ULW8	42.4	297	281	533	7.45e-59	199	PARP3_MOUSE	Protein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly [ADP-ribose] polymerase 3) (PARP-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)	Mus musculus (Mouse)	DNA ADP-ribosylation [GO:0030592]; double-strand break repair [GO:0006302]; negative regulation of isotype switching [GO:0045829]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to site of double-strand break [GO:1990166]; regulation of mitotic spindle organization [GO:0060236]; telomere maintenance [GO:0000723]	NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]	centriole [GO:0005814]; centrosome [GO:0005813]; chromosome [GO:0005694]; intercellular bridge [GO:0045171]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000723; GO:0003950; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005813; GO:0005814; GO:0006302; GO:0016604; GO:0030592; GO:0035861; GO:0045171; GO:0045829; GO:0060236; GO:0070213; GO:0140294; GO:0140804; GO:0140806; GO:0140807; GO:1990166; GO:1990404; GO:2001034
GN000180	GN000180.1	Q8BGA7	33.2	364	376	448	6.17e-41	152	INT15_MOUSE	Integrator complex subunit 15	Mus musculus (Mouse)	brain development [GO:0007420]; eye development [GO:0001654]; mRNA splicing, via spliceosome [GO:0000398]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; RNA polymerase II transcription initiation surveillance [GO:0160240]		chromosome [GO:0005694]; INTAC complex [GO:0160232]; integrator complex [GO:0032039]; nucleus [GO:0005634]	GO:0000398; GO:0001654; GO:0005634; GO:0005694; GO:0007420; GO:0032039; GO:0034243; GO:0160232; GO:0160240
GN000181	GN000181.1	Q8BGX0	55.1	323	404	574	1.44e-125	377	TRI23_MOUSE	E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)	Mus musculus (Mouse)	intracellular protein transport [GO:0006886]; positive regulation of autophagy [GO:0010508]; positive regulation of protein modification process [GO:0031401]; protein ubiquitination [GO:0016567]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000139; GO:0003924; GO:0004842; GO:0005525; GO:0005634; GO:0005737; GO:0005765; GO:0005886; GO:0006886; GO:0008270; GO:0010508; GO:0012505; GO:0016567; GO:0019003; GO:0031401; GO:0042802; GO:0061630
GN000182	GN000182.1	Q9H0H5	40.4	626	623	632	7.85e-135	411	RGAP1_HUMAN	Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)	Homo sapiens (Human)	actomyosin contractile ring assembly [GO:0000915]; erythrocyte differentiation [GO:0030218]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; neuroblast proliferation [GO:0007405]; positive regulation of cytokinesis [GO:0032467]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of embryonic development [GO:0045995]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; sulfate transmembrane transport [GO:1902358]	alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; gamma-tubulin binding [GO:0043015]; GTPase activator activity [GO:0005096]; microtubule binding [GO:0008017]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]	acrosomal vesicle [GO:0001669]; centralspindlin complex [GO:0097149]; cleavage furrow [GO:0032154]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; midbody [GO:0030496]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle midzone [GO:0051233]	GO:0000281; GO:0000915; GO:0001669; GO:0005096; GO:0005547; GO:0005634; GO:0005654; GO:0005739; GO:0005819; GO:0005829; GO:0007266; GO:0007283; GO:0007405; GO:0008017; GO:0009898; GO:0019901; GO:0030218; GO:0030496; GO:0030674; GO:0032154; GO:0032467; GO:0043014; GO:0043015; GO:0045995; GO:0048487; GO:0051056; GO:0051233; GO:0051256; GO:0051988; GO:0070062; GO:0072686; GO:0090543; GO:0097149; GO:1902358
GN000189	GN000189.1	Q9VCA2	33.1	142	134	548	5.06e-10	59.3	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN000190	GN000190.1	Q9VCA2	28.9	433	412	548	2.81e-44	164	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN000191	GN000191.1	Q9VCA2	29.9	461	513	548	4.48e-53	191	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN000192	GN000192.1	Q9P2P5	41.6	1724	1709	1572	0.0	1038	HECW2_HUMAN	E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)	Homo sapiens (Human)	protein ubiquitination [GO:0016567]; regulation of dendrite morphogenesis [GO:0048814]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]	GO:0005737; GO:0006511; GO:0016567; GO:0030071; GO:0048814; GO:0061630; GO:0072686
GN000199	GN000199.1	Q9UA35	44.2	572	639	683	1.65e-152	459	S28A3_EPTST	Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT)	Eptatretus stoutii (Pacific hagfish)	purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]	purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]	plasma membrane [GO:0005886]	GO:0005886; GO:0015389; GO:0015390; GO:0015860; GO:0015864
GN000200	GN000200.1	F6XBL2	71.2	416	416	422	8.21e-212	591	PSD11_XENTR	26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	proteasome assembly [GO:0043248]; stem cell differentiation [GO:0048863]; ubiquitin-dependent protein catabolic process [GO:0006511]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome regulatory particle, lid subcomplex [GO:0008541]	GO:0005198; GO:0005634; GO:0005829; GO:0006511; GO:0008541; GO:0022624; GO:0043248; GO:0048863
GN000201	GN000201.1	Q5R694	47.6	84	635	706	4.07e-13	76.3	CC177_PONAB	Coiled-coil domain-containing protein 177	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)				
GN000208	GN000208.1	Q17RP2	28.0	157	153	521	7.40e-11	62.4	TIGD6_HUMAN	Tigger transposable element-derived protein 6	Homo sapiens (Human)		DNA binding [GO:0003677]	nucleus [GO:0005634]	GO:0003677; GO:0005634
GN000209	GN000209.1	P61289	33.1	236	243	254	7.13e-38	135	PSME3_HUMAN	Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma)	Homo sapiens (Human)	apoptotic process [GO:0006915]; flagellated sperm motility [GO:0030317]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136]; response to oxidative stress [GO:0006979]	endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]; proteasome storage granule [GO:0034515]	GO:0000502; GO:0002039; GO:0005634; GO:0005654; GO:0005829; GO:0006915; GO:0006979; GO:0008537; GO:0016020; GO:0030317; GO:0034515; GO:0042802; GO:0061133; GO:0061136; GO:0097371; GO:2000045; GO:2001237
GN000210	GN000210.1	Q4FE47	38.4	125	273	462	7.64e-11	65.5	XB35_ARATH	Putative E3 ubiquitin-protein ligase XBAT35 (EC 2.3.2.27) (Ankyrin repeat domain and RING finger-containing protein XBAT35) (Protein XB3 homolog 5) (RING-type E3 ubiquitin transferase XBAT35)	Arabidopsis thaliana (Mouse-ear cress)	protein ubiquitination [GO:0016567]; regulation of programmed cell death [GO:0043067]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0004842; GO:0005634; GO:0005737; GO:0005794; GO:0005886; GO:0016567; GO:0043067; GO:0061630
GN000215	GN000215.1	P30626	43.2	139	266	198	5.70e-27	106	SORCN_HUMAN	Sorcin (22 kDa protein) (CP-22) (CP22) (V19)	Homo sapiens (Human)	negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of heart rate [GO:0010459]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of relaxation of muscle [GO:1901077]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; signal transduction [GO:0007165]	calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein sequestering activity [GO:0140311]; signaling receptor binding [GO:0005102]; transcription regulator inhibitor activity [GO:0140416]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; T-tubule [GO:0030315]; Z disc [GO:0030018]	GO:0002020; GO:0005102; GO:0005246; GO:0005509; GO:0005737; GO:0005789; GO:0005829; GO:0007165; GO:0010459; GO:0010649; GO:0010880; GO:0016020; GO:0016529; GO:0030018; GO:0030315; GO:0033017; GO:0042802; GO:0044325; GO:0046982; GO:0051281; GO:0051924; GO:0055118; GO:0061178; GO:0070062; GO:0086004; GO:0140297; GO:0140311; GO:0140416; GO:1901077; GO:1901844
GN000216	GN000216.1	Q27874	30.0	759	764	809	1.31e-86	294	PAT3_CAEEL	Integrin beta pat-3 (Paralyzed arrest at two-fold protein 3)	Caenorhabditis elegans	cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]; mitochondrion organization [GO:0007005]; muscle cell cellular homeostasis [GO:0046716]; muscle cell development [GO:0055001]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; positive regulation of axon regeneration [GO:0048680]; positive regulation of locomotion [GO:0040017]; positive regulation of myosin II filament organization [GO:1904901]; positive regulation of ovulation [GO:0060279]; positive regulation of sarcomere organization [GO:0060298]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of distal tip cell migration [GO:1903354]; regulation of vulval development [GO:0040028]; striated muscle cell development [GO:0055002]; vulval cell fate specification [GO:0072327]	integrin binding [GO:0005178]	basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; focal adhesion [GO:0005925]; integrin complex [GO:0008305]; lateral plasma membrane [GO:0016328]; M band [GO:0031430]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; striated muscle dense body [GO:0055120]; Z disc [GO:0030018]	GO:0005178; GO:0005604; GO:0005886; GO:0005925; GO:0007005; GO:0007160; GO:0007229; GO:0008305; GO:0009986; GO:0016323; GO:0016328; GO:0016477; GO:0030018; GO:0031430; GO:0032956; GO:0033627; GO:0040017; GO:0040028; GO:0042059; GO:0043005; GO:0043025; GO:0046716; GO:0048680; GO:0055001; GO:0055002; GO:0055120; GO:0060279; GO:0060298; GO:0072327; GO:0098609; GO:1903354; GO:1904901
GN000222	GN000222.1	Q9I8C7	43.8	320	457	452	6.03e-84	268	ACH10_CHICK	Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0050910; GO:0097060; GO:1902495
GN000224	GN000224.1	Q28199	47.6	307	289	307	3.84e-81	250	CD5R1_BOVIN	Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]	Bos taurus (Bovine)	axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; brain development [GO:0007420]; cerebral cortex radially oriented cell migration [GO:0021799]; embryo development ending in birth or egg hatching [GO:0009792]; ephrin receptor signaling pathway [GO:0048013]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; ionotropic glutamate receptor signaling pathway [GO:0035235]; negative regulation of DNA-templated transcription [GO:0045892]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of dendritic spine morphogenesis [GO:0061001]	actin filament binding [GO:0051015]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; ionotropic glutamate receptor binding [GO:0035255]; kinase activity [GO:0016301]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]	axon [GO:0030424]; contractile muscle fiber [GO:0043292]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; growth cone [GO:0030426]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein kinase 5 complex [GO:0016533]	GO:0000307; GO:0001764; GO:0002020; GO:0005509; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0007158; GO:0007213; GO:0007411; GO:0007413; GO:0007420; GO:0009792; GO:0014069; GO:0016020; GO:0016301; GO:0016533; GO:0019901; GO:0021799; GO:0030182; GO:0030424; GO:0030425; GO:0030426; GO:0031116; GO:0031175; GO:0031594; GO:0032956; GO:0035235; GO:0035255; GO:0043005; GO:0043014; GO:0043025; GO:0043197; GO:0043204; GO:0043292; GO:0043525; GO:0043539; GO:0045296; GO:0045892; GO:0048013; GO:0048471; GO:0048487; GO:0051015; GO:0061001; GO:0061575
GN000226	GN000226.1	Q8BTY2	41.8	766	819	1034	1.29e-181	551	S4A7_MOUSE	Sodium bicarbonate cotransporter 3 (Solute carrier family 4 member 7)	Mus musculus (Mouse)	auditory receptor cell development [GO:0060117]; bicarbonate transport [GO:0015701]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cellular response to growth factor stimulus [GO:0071363]; cochlear nucleus development [GO:0021747]; locomotory exploration behavior [GO:0035641]; phagosome acidification [GO:0090383]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; regulation of intracellular pH [GO:0051453]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal cell programmed cell death [GO:0046666]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]	GO:0005452; GO:0005737; GO:0005886; GO:0006164; GO:0006221; GO:0007601; GO:0007605; GO:0008509; GO:0008510; GO:0015701; GO:0016020; GO:0016323; GO:0016324; GO:0021747; GO:0031410; GO:0032420; GO:0035641; GO:0046666; GO:0051453; GO:0060117; GO:0060219; GO:0061299; GO:0071363; GO:0090383
GN000229	GN000229.1	O13134	37.9	240	234	1035	3.65e-43	158	S4A4_AMBTI	Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4)	Ambystoma tigrinum (Eastern tiger salamander)	regulation of intracellular pH [GO:0051453]	monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005452; GO:0005886; GO:0008509; GO:0008510; GO:0016323; GO:0051453
GN000230	GN000230.1	Q8BTY2	36.0	261	276	1034	2.60e-38	146	S4A7_MOUSE	Sodium bicarbonate cotransporter 3 (Solute carrier family 4 member 7)	Mus musculus (Mouse)	auditory receptor cell development [GO:0060117]; bicarbonate transport [GO:0015701]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cellular response to growth factor stimulus [GO:0071363]; cochlear nucleus development [GO:0021747]; locomotory exploration behavior [GO:0035641]; phagosome acidification [GO:0090383]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; regulation of intracellular pH [GO:0051453]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal cell programmed cell death [GO:0046666]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]	GO:0005452; GO:0005737; GO:0005886; GO:0006164; GO:0006221; GO:0007601; GO:0007605; GO:0008509; GO:0008510; GO:0015701; GO:0016020; GO:0016323; GO:0016324; GO:0021747; GO:0031410; GO:0032420; GO:0035641; GO:0046666; GO:0051453; GO:0060117; GO:0060219; GO:0061299; GO:0071363; GO:0090383
GN000234	GN000234.1	Q8BTY2	50.3	151	154	1034	3.29e-38	140	S4A7_MOUSE	Sodium bicarbonate cotransporter 3 (Solute carrier family 4 member 7)	Mus musculus (Mouse)	auditory receptor cell development [GO:0060117]; bicarbonate transport [GO:0015701]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cellular response to growth factor stimulus [GO:0071363]; cochlear nucleus development [GO:0021747]; locomotory exploration behavior [GO:0035641]; phagosome acidification [GO:0090383]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; regulation of intracellular pH [GO:0051453]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal cell programmed cell death [GO:0046666]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]	GO:0005452; GO:0005737; GO:0005886; GO:0006164; GO:0006221; GO:0007601; GO:0007605; GO:0008509; GO:0008510; GO:0015701; GO:0016020; GO:0016323; GO:0016324; GO:0021747; GO:0031410; GO:0032420; GO:0035641; GO:0046666; GO:0051453; GO:0060117; GO:0060219; GO:0061299; GO:0071363; GO:0090383
GN000235	GN000235.1	Q6RVG2	53.5	142	226	1092	4.54e-42	155	S4A8_RAT	Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na+-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3)	Rattus norvegicus (Rat)	basolateral protein secretion [GO:0110010]; bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; regulation of synaptic vesicle exocytosis [GO:2000300]; sodium ion transmembrane transport [GO:0035725]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; identical protein binding [GO:0042802]; sodium ion transmembrane transporter activity [GO:0015081]; sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; asymmetric synapse [GO:0032279]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber [GO:0097457]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; symmetric synapse [GO:0032280]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	GO:0005886; GO:0008021; GO:0008270; GO:0008510; GO:0015081; GO:0015106; GO:0015108; GO:0015701; GO:0016020; GO:0016323; GO:0016324; GO:0030425; GO:0030672; GO:0032279; GO:0032280; GO:0032809; GO:0035725; GO:0042391; GO:0042734; GO:0042802; GO:0043005; GO:0043195; GO:0043679; GO:0050804; GO:0051453; GO:0097386; GO:0097457; GO:0098793; GO:0098978; GO:0110010; GO:0140892; GO:1902476; GO:2000300; GO:2000302
GN000236	GN000236.1	O13134	48.2	494	617	1035	2.47e-137	429	S4A4_AMBTI	Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4)	Ambystoma tigrinum (Eastern tiger salamander)	regulation of intracellular pH [GO:0051453]	monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005452; GO:0005886; GO:0008509; GO:0008510; GO:0016323; GO:0051453
GN000238	GN000238.1	Q8JZR6	41.5	123	116	1089	1.48e-19	85.9	S4A8_MOUSE	Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na+-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3)	Mus musculus (Mouse)	basolateral protein secretion [GO:0110010]; bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; modulation of chemical synaptic transmission [GO:0050804]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; regulation of synaptic vesicle exocytosis [GO:2000300]; sodium ion transmembrane transport [GO:0035725]	bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; identical protein binding [GO:0042802]; sodium ion transmembrane transporter activity [GO:0015081]; sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; asymmetric synapse [GO:0032279]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber [GO:0097457]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; symmetric synapse [GO:0032280]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	GO:0005886; GO:0008021; GO:0008270; GO:0008510; GO:0015081; GO:0015106; GO:0015108; GO:0015701; GO:0016020; GO:0016323; GO:0016324; GO:0030425; GO:0030672; GO:0032279; GO:0032280; GO:0032809; GO:0035725; GO:0042391; GO:0042734; GO:0042802; GO:0043005; GO:0043195; GO:0043679; GO:0050804; GO:0051453; GO:0097386; GO:0097457; GO:0098793; GO:0098978; GO:0110010; GO:0140892; GO:1902476; GO:2000300; GO:2000302
GN000240	GN000240.1	Q9Y6R1	40.7	427	420	1079	1.00e-100	326	S4A4_HUMAN	Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1)	Homo sapiens (Human)	bicarbonate transport [GO:0015701]; positive regulation of glycolytic process [GO:0045821]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; sodium ion export across plasma membrane [GO:0036376]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	identical protein binding [GO:0042802]; monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]; symporter activity [GO:0015293]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005452; GO:0005886; GO:0006814; GO:0008509; GO:0008510; GO:0009986; GO:0015293; GO:0015701; GO:0016020; GO:0016323; GO:0035725; GO:0036376; GO:0042391; GO:0042802; GO:0045821; GO:0051453; GO:0055085; GO:0070062; GO:0150104
GN000244	GN000244.1	Q32LP4	42.8	1004	1081	1117	3.62e-252	746	S4A10_BOVIN	Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10)	Bos taurus (Bovine)	bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; visual perception [GO:0007601]	monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]	apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; presynapse [GO:0098793]; somatodendritic compartment [GO:0036477]; synapse [GO:0045202]	GO:0005452; GO:0007601; GO:0008509; GO:0008510; GO:0015701; GO:0016323; GO:0016324; GO:0030425; GO:0036477; GO:0043025; GO:0043204; GO:0043679; GO:0045202; GO:0048172; GO:0051453; GO:0098793; GO:0098794; GO:0098982
GN000245	GN000245.1	Q9YH58	60.7	532	535	541	4.40e-231	650	FTCD_CHICK	Formimidoyltransferase-cyclodeaminase (Formiminotransferase-cyclodeaminase) (FTCD) (p60) [Includes: Glutamate formimidoyltransferase (EC 2.1.2.5) (Glutamate formiminotransferase) (Glutamate formyltransferase); Formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) (Formiminotetrahydrofolate cyclodeaminase)]	Gallus gallus (Chicken)		folic acid binding [GO:0005542]; formimidoyltetrahydrofolate cyclodeaminase activity [GO:0030412]; glutamate formimidoyltransferase activity [GO:0030409]	centriole [GO:0005814]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005542; GO:0005794; GO:0005814; GO:0005829; GO:0030409; GO:0030412
GN000246	GN000246.1	Q9VUK8	65.3	98	136	765	4.50e-37	136	GARS_DROME	Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase)	Drosophila melanogaster (Fruit fly)	dendrite morphogenesis [GO:0048813]; glycyl-tRNA aminoacylation [GO:0006426]; mitochondrial glycyl-tRNA aminoacylation [GO:0070150]	ATP binding [GO:0005524]; ATP:ATP adenylyltransferase activity [GO:0141192]; glycine-tRNA ligase activity [GO:0004820]	axon [GO:0030424]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0004820; GO:0005524; GO:0005737; GO:0005739; GO:0006426; GO:0030424; GO:0048813; GO:0070150; GO:0141192
GN000248	GN000248.1	Q9VUK8	68.4	431	437	765	8.85e-209	597	GARS_DROME	Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase)	Drosophila melanogaster (Fruit fly)	dendrite morphogenesis [GO:0048813]; glycyl-tRNA aminoacylation [GO:0006426]; mitochondrial glycyl-tRNA aminoacylation [GO:0070150]	ATP binding [GO:0005524]; ATP:ATP adenylyltransferase activity [GO:0141192]; glycine-tRNA ligase activity [GO:0004820]	axon [GO:0030424]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0004820; GO:0005524; GO:0005737; GO:0005739; GO:0006426; GO:0030424; GO:0048813; GO:0070150; GO:0141192
GN000249	GN000249.1	Q6PEB4	49.1	387	395	414	1.51e-134	394	OSGL1_MOUSE	tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase-like protein 1) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1) (tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1)	Mus musculus (Mouse)	tRNA threonylcarbamoyladenosine modification [GO:0002949]	tRNA N(6)-L-threonylcarbamoyladenine synthase activity [GO:0061711]	mitochondrion [GO:0005739]	GO:0002949; GO:0005739; GO:0061711
GN000251	GN000251.1	Q96IW7	39.1	207	231	307	1.50e-39	141	SC22A_HUMAN	Vesicle-trafficking protein SEC22a (SEC22 vesicle-trafficking protein homolog A) (SEC22 vesicle-trafficking protein-like 2)	Homo sapiens (Human)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]	SNAP receptor activity [GO:0005484]	endoplasmic reticulum membrane [GO:0005789]	GO:0005484; GO:0005789; GO:0006888
GN000252	GN000252.1	Q9BTY2	50.1	433	454	467	4.22e-175	501	FUCO2_HUMAN	Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2)	Homo sapiens (Human)	fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]; regulation of entry of bacterium into host cell [GO:2000535]; response to bacterium [GO:0009617]	alpha-L-fucosidase activity [GO:0004560]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0004560; GO:0005576; GO:0005764; GO:0005788; GO:0006004; GO:0009617; GO:0016139; GO:0035578; GO:0070062; GO:2000535
GN000261	GN000261.1	P23330	87.4	430	442	451	8.95e-281	768	TBG1_XENLA	Tubulin gamma-1 chain (Gamma-1-tubulin) (xGAM)	Xenopus laevis (African clawed frog)	cytoplasmic microtubule organization [GO:0031122]; meiotic spindle organization [GO:0000212]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052]	GTP binding [GO:0005525]; microtubule nucleator activity [GO:0140490]; tubulin binding [GO:0015631]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; mitotic spindle microtubule [GO:1990498]; polar microtubule [GO:0005827]; spindle [GO:0005819]	GO:0000070; GO:0000212; GO:0000278; GO:0000930; GO:0000931; GO:0005525; GO:0005737; GO:0005813; GO:0005819; GO:0005827; GO:0007020; GO:0007052; GO:0015631; GO:0031122; GO:0140490; GO:1990498
GN000262	GN000262.1	Q9GM70	56.2	276	454	397	1.42e-106	324	ST17A_RABIT	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1) (rDRAK1)	Oryctolagus cuniculus (Rabbit)	apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; regulation of reactive oxygen species metabolic process [GO:2000377]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	nucleus [GO:0005634]	GO:0004674; GO:0005524; GO:0005634; GO:0006915; GO:0035556; GO:0043065; GO:0106310; GO:2000377
GN000263	GN000263.1	Q9DBL7	38.7	556	562	563	3.36e-122	374	COASY_MOUSE	Bifunctional coenzyme A synthase (CoA synthase) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (DPCOAK)]	Mus musculus (Mouse)	coenzyme A biosynthetic process [GO:0015937]	ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140]; pantetheine-phosphate adenylyltransferase activity [GO:0004595]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; sperm head-tail coupling apparatus [GO:0120212]	GO:0004140; GO:0004595; GO:0005524; GO:0005739; GO:0005741; GO:0005759; GO:0005829; GO:0015937; GO:0120212
GN000264	GN000264.1	Q969S3	39.9	476	1211	477	2.44e-83	283	ZN622_HUMAN	Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9)	Homo sapiens (Human)	intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; ribosomal large subunit biogenesis [GO:0042273]	preribosome binding [GO:1990275]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, large subunit precursor [GO:0030687]	GO:0003723; GO:0005654; GO:0005730; GO:0005829; GO:0008270; GO:0008631; GO:0030687; GO:0033674; GO:0042273; GO:0043065; GO:0043410; GO:0046330; GO:1990275
GN000265	GN000265.1	P32870	27.8	162	213	2248	1.44e-11	66.6	CYA1_DROME	Adenylate cyclase 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Ca(2+)/calmodulin-responsive adenylate cyclase) (Protein rutabaga)	Drosophila melanogaster (Fruit fly)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; anesthesia-resistant memory [GO:0007615]; associative learning [GO:0008306]; axon extension [GO:0048675]; behavioral response to ethanol [GO:0048149]; cAMP biosynthetic process [GO:0006171]; chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; conditioned taste aversion [GO:0001661]; courtship behavior [GO:0007619]; cyclic nucleotide biosynthetic process [GO:0009190]; determination of adult lifespan [GO:0008340]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; learning or memory [GO:0007611]; mating behavior [GO:0007617]; medium-term memory [GO:0072375]; memory [GO:0007613]; molting cycle, chitin-based cuticle [GO:0007591]; neuromuscular junction development [GO:0007528]; neuromuscular synaptic transmission [GO:0007274]; olfactory learning [GO:0008355]; regulation of olfactory learning [GO:0090328]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; short-term memory [GO:0007614]; sleep [GO:0030431]	adenylate cyclase activity [GO:0004016]; calcium- and calmodulin-responsive adenylate cyclase activity [GO:0008294]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0001661; GO:0004016; GO:0005886; GO:0006171; GO:0006979; GO:0007189; GO:0007268; GO:0007274; GO:0007528; GO:0007591; GO:0007611; GO:0007612; GO:0007613; GO:0007614; GO:0007615; GO:0007617; GO:0007619; GO:0007623; GO:0008294; GO:0008306; GO:0008340; GO:0008355; GO:0009190; GO:0009408; GO:0016020; GO:0030431; GO:0035556; GO:0045202; GO:0048149; GO:0048675; GO:0072375; GO:0090328
GN000266	GN000266.1	P53801	50.4	139	197	180	1.59e-30	113	PTTG_HUMAN	Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor)	Homo sapiens (Human)	negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of protein ubiquitination [GO:0031398]; protein import into nucleus [GO:0006606]	p53 binding [GO:0002039]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0002039; GO:0005634; GO:0005654; GO:0005737; GO:0006606; GO:0016020; GO:0031398; GO:0043518; GO:0070062; GO:1902254
GN000267	GN000267.1	O43242	67.3	468	502	534	6.10e-216	610	PSMD3_HUMAN	26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)	Homo sapiens (Human)	cellular response to type I interferon [GO:0071357]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of proteasomal protein catabolic process [GO:0061136]; response to oxidative stress [GO:0006979]; ubiquitin-dependent protein catabolic process [GO:0006511]	enzyme regulator activity [GO:0030234]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]; synaptic vesicle [GO:0008021]	GO:0000502; GO:0005576; GO:0005634; GO:0005654; GO:0005829; GO:0006511; GO:0006979; GO:0008021; GO:0008541; GO:0010498; GO:0016020; GO:0022624; GO:0030234; GO:0034774; GO:0043161; GO:0061136; GO:0070062; GO:0071357; GO:1904813
GN000272	GN000272.1	Q63ZL2	48.7	199	218	214	3.88e-56	180	HOP2_XENLA	Homologous-pairing protein 2 homolog (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein)	Xenopus laevis (African clawed frog)	homologous chromosome pairing at meiosis [GO:0007129]; meiotic joint molecule formation [GO:0000709]; meiotic strand invasion involved in reciprocal meiotic recombination [GO:0010774]	double-stranded DNA binding [GO:0003690]; recombinase activator activity [GO:0120230]	condensed nuclear chromosome [GO:0000794]; DNA recombinase auxiliary factor complex [GO:0120231]	GO:0000709; GO:0000794; GO:0003690; GO:0007129; GO:0010774; GO:0120230; GO:0120231
GN000281	GN000281.1	Q6XUX2	31.6	297	1478	927	4.26e-26	120	DUSTY_RAT	Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5)	Rattus norvegicus (Rat)	cellular response to fibroblast growth factor stimulus [GO:0044344]; negative regulation of apoptotic process [GO:0043066]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of kinase activity [GO:0033674]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004712; GO:0004713; GO:0005524; GO:0005737; GO:0005886; GO:0016323; GO:0016324; GO:0033674; GO:0043066; GO:0044344; GO:0045743; GO:0070161; GO:0070374; GO:0106310
GN000282	GN000282.1	Q8JFZ2	31.2	218	231	212	6.91e-20	87.4	GSTP1_XENLA	Glutathione S-transferase P 1 (EC 2.5.1.18) (GST class-pi) (GST-Pi) (XlGSTP1-1)	Xenopus laevis (African clawed frog)	glutathione metabolic process [GO:0006749]; neural precursor cell proliferation [GO:0061351]	glutathione transferase activity [GO:0004364]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0004364; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0006749; GO:0061351
GN000283	GN000283.1	M4DUF2	29.3	601	721	570	1.61e-61	219	ASO_BRARP	L-ascorbate oxidase (AAO) (AO) (ASO) (Ascorbase) (EC 1.10.3.3)	Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica pekinensis)	L-ascorbic acid catabolic process [GO:0019854]; negative regulation of defense response to virus [GO:0050687]; response to hydrogen peroxide [GO:0042542]; response to jasmonic acid [GO:0009753]; response to virus [GO:0009615]	copper ion binding [GO:0005507]; L-ascorbate oxidase activity [GO:0008447]	extracellular region [GO:0005576]; plasmodesma [GO:0009506]	GO:0005507; GO:0005576; GO:0008447; GO:0009506; GO:0009615; GO:0009753; GO:0019854; GO:0042542; GO:0050687
GN000289	GN000289.1	P04464	29.6	135	239	149	1.80e-12	66.2	CALM_WHEAT	Calmodulin (CaM)	Triticum aestivum (Wheat)		calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]	GO:0005509; GO:0005737; GO:0019904; GO:0030234
GN000290	GN000290.1	Q8K0Z7	29.7	246	299	294	4.88e-22	96.7	TACO1_MOUSE	Translational activator of cytochrome c oxidase 1 (Coiled-coil domain-containing protein 44) (Translational activator of mitochondrially-encoded cytochrome c oxidase 1)	Mus musculus (Mouse)	mitochondrial respiratory chain complex IV assembly [GO:0033617]; motor learning [GO:0061743]; positive regulation of mitochondrial translation [GO:0070131]; regulation of cytochrome-c oxidase activity [GO:1904959]; regulation of mitochondrial translation [GO:0070129]	mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; rRNA binding [GO:0019843]	mitochondrion [GO:0005739]	GO:0003729; GO:0005739; GO:0019843; GO:0033617; GO:0061743; GO:0070129; GO:0070131; GO:0097177; GO:1904959
GN000292	GN000292.1	A0A2B4RNI3	33.6	152	752	688	6.37e-18	92.0	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN000294	GN000294.1	Q7ZSX3	53.9	89	148	265	2.06e-16	76.6	PTF1A_DANRE	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48)	Danio rerio (Zebrafish) (Brachydanio rerio)	amacrine cell differentiation [GO:0035881]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; developmental process [GO:0032502]; exocrine pancreas development [GO:0031017]; generation of neurons [GO:0048699]; hindbrain development [GO:0030902]; neuron development [GO:0048666]; pancreas development [GO:0031016]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retinoic acid receptor signaling pathway [GO:0048384]; tissue development [GO:0009888]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000977; GO:0000981; GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0005737; GO:0006355; GO:0006357; GO:0009887; GO:0009888; GO:0030154; GO:0030902; GO:0031016; GO:0031017; GO:0032502; GO:0035881; GO:0043565; GO:0045893; GO:0046983; GO:0048384; GO:0048666; GO:0048699
GN000297	GN000297.1	P31429	44.9	383	449	410	1.82e-106	324	DPEP1_RABIT	Dipeptidase 1 (EC 3.4.13.19) (43 kDa renal band 3-related protein) (Beta-lactamase) (EC 3.5.2.6) (Microsomal dipeptidase)	Oryctolagus cuniculus (Rabbit)	antibiotic metabolic process [GO:0016999]; cellular response to calcium ion [GO:0071277]; cellular response to nitric oxide [GO:0071732]; glutathione catabolic process [GO:0006751]; homocysteine metabolic process [GO:0050667]; inflammatory response [GO:0006954]; leukotriene D4 catabolic process [GO:1901749]; leukotriene metabolic process [GO:0006691]; negative regulation of cell migration [GO:0030336]; neutrophil chemotaxis [GO:0030593]; proteolysis [GO:0006508]	beta-lactamase activity [GO:0008800]; dipeptidase activity [GO:0016805]; GPI anchor binding [GO:0034235]; metallodipeptidase activity [GO:0070573]; modified amino acid binding [GO:0072341]; zinc ion binding [GO:0008270]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	GO:0005576; GO:0005886; GO:0006508; GO:0006691; GO:0006751; GO:0006954; GO:0008270; GO:0008800; GO:0016324; GO:0016805; GO:0016999; GO:0030336; GO:0030593; GO:0031528; GO:0034235; GO:0045177; GO:0050667; GO:0070573; GO:0071277; GO:0071732; GO:0072341; GO:1901749
GN000299	GN000299.1	Q3UQ28	36.0	317	314	1475	3.04e-43	162	PXDN_MOUSE	Peroxidasin homolog (EC 1.11.2.-) [Cleaved into: PXDN active fragment]	Mus musculus (Mouse)	angiogenesis [GO:0001525]; basement membrane assembly [GO:0070831]; basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; hydrogen peroxide catabolic process [GO:0042744]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; response to oxidative stress [GO:0006979]	extracellular matrix structural constituent [GO:0005201]; heme binding [GO:0020037]; laminin-1 binding [GO:0043237]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]	basement membrane [GO:0005604]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0001525; GO:0001654; GO:0004601; GO:0005201; GO:0005576; GO:0005604; GO:0005783; GO:0006979; GO:0007155; GO:0009986; GO:0016684; GO:0020037; GO:0030198; GO:0030199; GO:0031012; GO:0042744; GO:0043237; GO:0051260; GO:0070207; GO:0070831; GO:0071711
GN000300	GN000300.1	Q8WWB3	40.9	88	741	177	2.90e-09	60.5	DYDC1_HUMAN	DPY30 domain-containing protein 1	Homo sapiens (Human)	cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]		9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cilium [GO:0005929]; radial spoke [GO:0001534]; Set1C/COMPASS complex [GO:0048188]; sperm flagellum [GO:0036126]	GO:0001534; GO:0003341; GO:0005929; GO:0005930; GO:0030317; GO:0036126; GO:0048188; GO:0097729
GN000302	GN000302.1	B5T255	44.4	171	274	190	2.29e-47	159	PGRP1_BOSIN	Peptidoglycan recognition protein 1	Bos indicus (Zebu)	defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; innate immune response [GO:0045087]; peptidoglycan catabolic process [GO:0009253]	N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0005576; GO:0008270; GO:0008745; GO:0009253; GO:0016019; GO:0016045; GO:0042834; GO:0045087; GO:0050830
GN000303	GN000303.1	B8JKD7	53.4	1138	1128	1132	0.0	1206	RPA2_DANRE	DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6)	Danio rerio (Zebrafish) (Brachydanio rerio)	neural crest formation [GO:0014029]; transcription elongation by RNA polymerase I [GO:0006362]	5'-3' RNA polymerase activity [GO:0034062]; DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]; ribonucleoside binding [GO:0032549]	chromosome [GO:0005694]; RNA polymerase I complex [GO:0005736]	GO:0003677; GO:0003899; GO:0005694; GO:0005736; GO:0006362; GO:0014029; GO:0032549; GO:0034062
GN000304	GN000304.1	A0JMH2	33.1	317	290	341	9.56e-52	176	CB069_DANRE	Mitochondrial protein C2orf69 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)			mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759
GN000305	GN000305.1	Q6AYQ6	42.5	285	316	296	1.24e-67	216	MMAD_RAT	Cobalamin trafficking protein CblD (CblD) (Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial)	Rattus norvegicus (Rat)	cobalamin metabolic process [GO:0009235]	molecular carrier activity [GO:0140104]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0005737; GO:0005739; GO:0005829; GO:0009235; GO:0140104
GN000310	GN000310.1	Q95245	43.8	224	249	252	1.76e-55	181	CY561_PIG	Transmembrane ascorbate-dependent reductase CYB561 (EC 7.2.1.-) (Cytochrome b-561) (Cytochrome b561)	Sus scrofa (Pig)	ascorbate homeostasis [GO:0140576]; intracellular iron ion homeostasis [GO:0006879]	transmembrane monodehydroascorbate reductase activity [GO:0140575]	chromaffin granule membrane [GO:0042584]	GO:0006879; GO:0042584; GO:0140575; GO:0140576
GN000311	GN000311.1	Q9ERH8	45.5	573	691	703	6.31e-151	457	S28A3_MOUSE	Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (mCNT3)	Mus musculus (Mouse)	nucleoside transmembrane transport [GO:1901642]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; pyrimidine-containing compound transmembrane transport [GO:0072531]; retina homeostasis [GO:0001895]; uridine transmembrane transport [GO:0015862]	purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213]	brush border membrane [GO:0031526]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0001895; GO:0005789; GO:0005886; GO:0015213; GO:0015389; GO:0015390; GO:0015860; GO:0015862; GO:0015864; GO:0031526; GO:0072531; GO:1901642
GN000312	GN000312.1	Q9ERH8	49.0	459	625	703	3.32e-147	445	S28A3_MOUSE	Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (mCNT3)	Mus musculus (Mouse)	nucleoside transmembrane transport [GO:1901642]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; pyrimidine-containing compound transmembrane transport [GO:0072531]; retina homeostasis [GO:0001895]; uridine transmembrane transport [GO:0015862]	purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213]	brush border membrane [GO:0031526]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0001895; GO:0005789; GO:0005886; GO:0015213; GO:0015389; GO:0015390; GO:0015860; GO:0015862; GO:0015864; GO:0031526; GO:0072531; GO:1901642
GN000313	GN000313.1	Q9ERH8	52.1	436	526	703	1.20e-151	453	S28A3_MOUSE	Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (mCNT3)	Mus musculus (Mouse)	nucleoside transmembrane transport [GO:1901642]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; pyrimidine-containing compound transmembrane transport [GO:0072531]; retina homeostasis [GO:0001895]; uridine transmembrane transport [GO:0015862]	purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213]	brush border membrane [GO:0031526]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0001895; GO:0005789; GO:0005886; GO:0015213; GO:0015389; GO:0015390; GO:0015860; GO:0015862; GO:0015864; GO:0031526; GO:0072531; GO:1901642
GN000314	GN000314.1	P15848	36.3	102	106	533	2.77e-10	58.9	ARSB_HUMAN	Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S)	Homo sapiens (Human)	autophagy [GO:0006914]; chondroitin sulfate proteoglycan catabolic process [GO:0030207]; colon epithelial cell migration [GO:0061580]; lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268]	arylsulfatase activity [GO:0004065]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943]; sulfuric ester hydrolase activity [GO:0008484]	azurophil granule lumen [GO:0035578]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	GO:0003943; GO:0004065; GO:0005576; GO:0005764; GO:0005788; GO:0006914; GO:0007040; GO:0007041; GO:0007584; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0030207; GO:0035578; GO:0043202; GO:0043627; GO:0051597; GO:0061580; GO:0070062; GO:1904813
GN000315	GN000315.1	P50429	39.7	504	484	534	5.50e-124	375	ARSB_MOUSE	Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S)	Mus musculus (Mouse)	anterior head development [GO:0097065]; autophagy [GO:0006914]; chondroitin sulfate proteoglycan catabolic process [GO:0030207]; colon epithelial cell migration [GO:0061580]; dermatan sulfate proteoglycan catabolic process [GO:0030209]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268]	arylsulfatase activity [GO:0004065]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943]; N-acetylgalactosamine-6-sulfatase activity [GO:0043890]; sulfuric ester hydrolase activity [GO:0008484]	cell surface [GO:0009986]; lysosome [GO:0005764]	GO:0003943; GO:0004065; GO:0005764; GO:0006914; GO:0007584; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0030207; GO:0030209; GO:0043627; GO:0043890; GO:0051597; GO:0061580; GO:0097065
GN000316	GN000316.1	Q32KH7	32.4	259	211	573	3.53e-30	119	ARSI_CANLF	Arylsulfatase I (ASI) (EC 3.1.6.-)	Canis lupus familiaris (Dog) (Canis familiaris)		sulfuric ester hydrolase activity [GO:0008484]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]	GO:0005576; GO:0005783; GO:0008484
GN000317	GN000317.1	P50430	40.3	449	415	528	2.06e-105	324	ARSB_RAT	Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S)	Rattus norvegicus (Rat)	anterior head development [GO:0097065]; autophagy [GO:0006914]; chondroitin sulfate proteoglycan catabolic process [GO:0030207]; colon epithelial cell migration [GO:0061580]; dermatan sulfate proteoglycan catabolic process [GO:0030209]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268]	arylsulfatase activity [GO:0004065]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943]; N-acetylgalactosamine-6-sulfatase activity [GO:0043890]; sulfuric ester hydrolase activity [GO:0008484]	cell surface [GO:0009986]; lysosome [GO:0005764]	GO:0003943; GO:0004065; GO:0005764; GO:0006914; GO:0007584; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0030207; GO:0030209; GO:0043627; GO:0043890; GO:0051597; GO:0061580; GO:0097065
GN000318	GN000318.1	O01427	35.2	162	788	305	4.31e-14	77.4	AIR2_CAEEL	Aurora/IPL1-related protein kinase 2 (EC 2.7.11.1) (Serine/threonine-protein kinase aurora-B)	Caenorhabditis elegans	chromosome condensation [GO:0030261]; chromosome segregation [GO:0007059]; establishment of protein localization [GO:0045184]; meiotic spindle midzone assembly [GO:0051257]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic sister chromatid separation [GO:1901970]; regulation of actomyosin contractile ring contraction [GO:0031991]; regulation of cytokinesis [GO:0032465]	ATP binding [GO:0005524]; ATPase binding [GO:0051117]; histone H3 kinase activity [GO:0140996]; kinesin binding [GO:0019894]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome passenger complex [GO:0032133]; condensed chromosome [GO:0000793]; condensed nuclear chromosome [GO:0000794]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]	GO:0000278; GO:0000281; GO:0000776; GO:0000793; GO:0000794; GO:0000922; GO:0004672; GO:0004674; GO:0005524; GO:0005694; GO:0005813; GO:0005819; GO:0005876; GO:0007052; GO:0007059; GO:0015630; GO:0019894; GO:0030261; GO:0030496; GO:0031991; GO:0032133; GO:0032465; GO:0045184; GO:0051117; GO:0051233; GO:0051256; GO:0051257; GO:0090267; GO:0106310; GO:0140996; GO:1901970
GN000320	GN000320.1	Q9ERH8	56.3	419	638	703	4.59e-151	456	S28A3_MOUSE	Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (mCNT3)	Mus musculus (Mouse)	nucleoside transmembrane transport [GO:1901642]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; pyrimidine-containing compound transmembrane transport [GO:0072531]; retina homeostasis [GO:0001895]; uridine transmembrane transport [GO:0015862]	purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213]	brush border membrane [GO:0031526]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0001895; GO:0005789; GO:0005886; GO:0015213; GO:0015389; GO:0015390; GO:0015860; GO:0015862; GO:0015864; GO:0031526; GO:0072531; GO:1901642
GN000321	GN000321.1	P13634	34.6	159	624	261	1.01e-23	104	CAH1_MOUSE	Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase I) (CA-I) (Cyanamide hydratase CA1) (EC 4.2.1.69)	Mus musculus (Mouse)	response to fructose [GO:0009750]	arylesterase activity [GO:0004064]; carbonate dehydratase activity [GO:0004089]; cyanamide hydratase activity [GO:0018820]; hydro-lyase activity [GO:0016836]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0004064; GO:0004089; GO:0005737; GO:0008270; GO:0009750; GO:0016836; GO:0018820
GN000322	GN000322.1	Q8IUH3	34.6	500	502	476	1.98e-88	282	RBM45_HUMAN	RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45)	Homo sapiens (Human)	nervous system development [GO:0007399]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0007399; GO:0042802; GO:1990904
GN000323	GN000323.1	Q008X1	37.0	135	170	171	2.40e-14	70.1	DFP_BOMMO	Putative defense protein	Bombyx mori (Silk moth)	defense response to protozoan [GO:0042832]		extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020; GO:0042832
GN000324	GN000324.1	Q5F389	61.2	49	90	414	5.96e-11	60.1	WWOX_CHICK	WW domain-containing oxidoreductase (EC 1.1.1.-)	Gallus gallus (Chicken)	cellular response to transforming growth factor beta stimulus [GO:0071560]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of transcription by RNA polymerase II [GO:0045944]	enzyme binding [GO:0019899]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; microvillus [GO:0005902]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0003713; GO:0005654; GO:0005737; GO:0005739; GO:0005764; GO:0005794; GO:0005829; GO:0005886; GO:0005902; GO:0019899; GO:0030178; GO:0045944; GO:0071560; GO:0090575; GO:2001238
GN000327	GN000327.1	Q96KC8	26.7	415	389	554	4.46e-28	119	DNJC1_HUMAN	DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1)	Homo sapiens (Human)	negative regulation of proteolysis [GO:0045861]; regulation of protein secretion [GO:0050708]	ATPase activator activity [GO:0001671]; protein-folding chaperone binding [GO:0051087]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0001671; GO:0005783; GO:0005789; GO:0005886; GO:0012505; GO:0016020; GO:0031965; GO:0045861; GO:0050708; GO:0051087
GN000331	GN000331.1	Q96KC2	79.1	139	142	179	2.02e-81	240	ARL5B_HUMAN	ADP-ribosylation factor-like protein 5B (ADP-ribosylation factor-like protein 8)	Homo sapiens (Human)	intracellular protein transport [GO:0006886]; protein localization to Golgi membrane [GO:1903292]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	trans-Golgi network [GO:0005802]	GO:0003924; GO:0005525; GO:0005802; GO:0006886; GO:1903292
GN000338	GN000338.1	A5YVV0	32.6	221	369	661	5.60e-29	121	LAC3_ANOGA	Multicopper oxidase 3 (AgMCO3) (EC 1.10.3.2) (Laccase-3)	Anopheles gambiae (African malaria mosquito)		copper ion binding [GO:0005507]; hydroquinone:oxygen oxidoreductase activity [GO:0052716]	extracellular region [GO:0005576]	GO:0005507; GO:0005576; GO:0052716
GN000339	GN000339.1	P49281	67.7	493	580	568	4.06e-228	645	NRAM2_HUMAN	Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2)	Homo sapiens (Human)	cadmium ion transmembrane transport [GO:0070574]; cellular response to oxidative stress [GO:0034599]; cobalt ion transport [GO:0006824]; copper ion transport [GO:0006825]; detection of oxygen [GO:0003032]; intracellular iron ion homeostasis [GO:0006879]; intracellular manganese ion homeostasis [GO:0030026]; iron import into cell [GO:0033212]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]; lead ion transport [GO:0015692]; manganese ion transport [GO:0006828]; metal ion transport [GO:0030001]; multicellular organismal-level iron ion homeostasis [GO:0060586]; nickel cation transport [GO:0015675]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; vanadium ion transport [GO:0015676]	cadmium ion binding [GO:0046870]; cadmium ion transmembrane transporter activity [GO:0015086]; cobalt ion transmembrane transporter activity [GO:0015087]; copper ion transmembrane transporter activity [GO:0005375]; ferrous iron transmembrane transporter activity [GO:0015093]; iron ion transmembrane transporter activity [GO:0005381]; lead ion transmembrane transporter activity [GO:0015094]; manganese ion transmembrane transporter activity [GO:0005384]; nickel cation transmembrane transporter activity [GO:0015099]; retromer complex binding [GO:1905394]; solute:proton symporter activity [GO:0015295]; transition metal ion transmembrane transporter activity [GO:0046915]; transmembrane transporter activity [GO:0022857]; vanadium ion transmembrane transporter activity [GO:0015100]; zinc ion transmembrane transporter activity [GO:0005385]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basal part of cell [GO:0045178]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; paraferritin complex [GO:0070826]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773]	GO:0001666; GO:0003032; GO:0005375; GO:0005381; GO:0005384; GO:0005385; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005764; GO:0005765; GO:0005769; GO:0005770; GO:0005773; GO:0005794; GO:0005802; GO:0005886; GO:0006824; GO:0006825; GO:0006826; GO:0006828; GO:0006879; GO:0009986; GO:0010008; GO:0010039; GO:0015086; GO:0015087; GO:0015093; GO:0015094; GO:0015099; GO:0015100; GO:0015295; GO:0015675; GO:0015676; GO:0015692; GO:0016020; GO:0016324; GO:0022857; GO:0030001; GO:0030026; GO:0031410; GO:0031526; GO:0031901; GO:0031902; GO:0033212; GO:0034599; GO:0034755; GO:0045177; GO:0045178; GO:0046870; GO:0046915; GO:0048471; GO:0055037; GO:0055038; GO:0060586; GO:0070574; GO:0070826; GO:1903561; GO:1905394
GN000340	GN000340.1	Q0P5F0	42.9	308	333	423	5.33e-76	242	PPAL_BOVIN	Lysosomal acid phosphatase (LAP) (EC 3.1.3.2)	Bos taurus (Bovine)	lysosome organization [GO:0007040]	acid phosphatase activity [GO:0003993]	lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]	GO:0003993; GO:0005764; GO:0005765; GO:0007040; GO:0043202
GN000344	GN000344.1	P00176	31.5	496	493	491	1.19e-71	238	CP2B1_RAT	Cytochrome P450 2B1 (EC 1.14.14.1) (CYPIIB1) (Cytochrome P450-B) (Cytochrome P450b) (Cytochrome P450-LM2) (Cytochrome P450-PB1) (Cytochrome P450-PB2)	Rattus norvegicus (Rat)	epoxygenase P450 pathway [GO:0019373]; response to calcium ion [GO:0051592]; response to insulin [GO:0032868]; response to metal ion [GO:0010038]; response to sulfur dioxide [GO:0010477]; response to xenobiotic stimulus [GO:0009410]; xenobiotic metabolic process [GO:0006805]	arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]	GO:0005506; GO:0005737; GO:0005743; GO:0005789; GO:0006805; GO:0008392; GO:0008395; GO:0009410; GO:0010038; GO:0010477; GO:0016712; GO:0019373; GO:0020037; GO:0030544; GO:0032868; GO:0051592; GO:0051879
GN000348	GN000348.1	Q8CG65	26.5	596	1260	4998	4.57e-45	183	SSPO_MOUSE	SCO-spondin	Mus musculus (Mouse)		extracellular matrix structural constituent [GO:0005201]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]	GO:0005201; GO:0005737; GO:0031012
GN000373	GN000373.1	A7YT82	58.7	358	452	492	2.82e-135	401	NMT2_DANRE	Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Peptide N-myristoyltransferase 2) (Type II N-myristoyltransferase)	Danio rerio (Zebrafish) (Brachydanio rerio)	N-terminal peptidyl-glycine N-myristoylation [GO:0018008]; protein localization to membrane [GO:0072657]	CoA-dependent peptidyl-lysine N6-myristoyltransferase activity [GO:0140770]; glycylpeptide N-tetradecanoyltransferase activity [GO:0004379]; peptidyl-lysine N6-myristoyltransferase activity [GO:0018030]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0004379; GO:0005737; GO:0016020; GO:0018008; GO:0018030; GO:0072657; GO:0140770
GN000374	GN000374.1	Q32L26	59.5	168	173	212	6.97e-67	206	CLXN_BOVIN	Calaxin (EF-hand calcium-binding domain-containing protein 1)	Bos taurus (Bovine)	cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]; regulation of cilium movement [GO:0003352]; regulation of flagellated sperm motility [GO:1901317]; regulation of signal transduction [GO:0009966]	calcium ion binding [GO:0005509]	cilium [GO:0005929]; outer dynein arm docking complex [GO:0120228]; sperm flagellum [GO:0036126]	GO:0003341; GO:0003352; GO:0005509; GO:0005929; GO:0009966; GO:0036126; GO:0036158; GO:0120228; GO:1901317
GN000376	GN000376.1	Q29497	34.6	246	266	509	2.98e-36	137	CP17A_SHEEP	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)	Ovis aries (Sheep)	glucocorticoid biosynthetic process [GO:0006704]; hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid metabolic process [GO:0008202]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	endoplasmic reticulum membrane [GO:0005789]	GO:0004508; GO:0005506; GO:0005789; GO:0006704; GO:0008202; GO:0020037; GO:0042446; GO:0042448
GN000377	GN000377.1	Q8K2X2	59.4	133	421	371	2.45e-45	164	RBM48_MOUSE	RNA-binding protein 48	Mus musculus (Mouse)		nucleic acid binding [GO:0003676]	nucleoplasm [GO:0005654]; U12-type catalytic step 2 spliceosome [GO:0071018]	GO:0003676; GO:0005654; GO:0071018
GN000378	GN000378.1	P02637	44.3	176	175	176	8.28e-46	151	SCP_MIZYE	Sarcoplasmic calcium-binding protein (SCP)	Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis)		calcium ion binding [GO:0005509]		GO:0005509
GN000380	GN000380.1	P20918	43.1	174	1087	812	1.87e-36	152	PLMN_MOUSE	Plasminogen [Cleaved into: Plasmin (EC 3.4.21.7); Plasmin heavy chain A; Plasmin light chain B; Angiostatin]	Mus musculus (Mouse)	biological process involved in interaction with symbiont [GO:0051702]; blood coagulation [GO:0007596]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; fibrinolysis [GO:0042730]; labyrinthine layer blood vessel development [GO:0060716]; mononuclear cell migration [GO:0071674]; muscle cell cellular homeostasis [GO:0046716]; myoblast differentiation [GO:0045445]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of fibrinolysis [GO:0051919]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; tissue regeneration [GO:0042246]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]; trophoblast giant cell differentiation [GO:0060707]	apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein antigen binding [GO:1990405]; protein domain specific binding [GO:0019904]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0002020; GO:0004175; GO:0004252; GO:0005102; GO:0005576; GO:0006508; GO:0007596; GO:0009897; GO:0009986; GO:0010812; GO:0016485; GO:0016525; GO:0019899; GO:0019900; GO:0019904; GO:0022617; GO:0030163; GO:0030574; GO:0031012; GO:0034185; GO:0042246; GO:0042730; GO:0043536; GO:0045445; GO:0046716; GO:0051087; GO:0051702; GO:0051918; GO:0051919; GO:0060707; GO:0060716; GO:0071674; GO:0098685; GO:0098978; GO:0099183; GO:1990405
GN000381	GN000381.1	D3YXG0	23.3	2120	2889	5634	7.35e-81	303	HMCN1_MOUSE	Hemicentin-1 (Fibulin-6) (FIBL-6)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]; response to bacterium [GO:0009617]	calcium ion binding [GO:0005509]; cell adhesion mediator activity [GO:0098631]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; muscle tendon junction [GO:0005927]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005509; GO:0005576; GO:0005604; GO:0005737; GO:0005886; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0009617; GO:0030036; GO:0030054; GO:0031012; GO:0032154; GO:0070161; GO:0071711; GO:0098631; GO:0140144
GN000382	GN000382.1	P24668	42.3	78	161	278	4.74e-09	57.0	MPRD_MOUSE	Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)	Mus musculus (Mouse)	Golgi to lysosome transport [GO:0090160]; intracellular protein transport [GO:0006886]; lysosomal transport [GO:0007041]; protein targeting to lysosome [GO:0006622]; secretion of lysosomal enzymes [GO:0033299]	cargo receptor activity [GO:0038024]; protein domain specific binding [GO:0019904]; retromer complex binding [GO:1905394]	cytosol [GO:0005829]; endosome [GO:0005768]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802]	GO:0005765; GO:0005768; GO:0005770; GO:0005802; GO:0005829; GO:0006622; GO:0006886; GO:0007041; GO:0019904; GO:0033299; GO:0038024; GO:0048471; GO:0090160; GO:1905394
GN000383	GN000383.1	Q9Y238	34.9	1744	1731	1755	3.91e-312	944	DLEC1_HUMAN	Deleted in lung and esophageal cancer protein 1 (Deleted in lung cancer protein 1) (DLC-1)	Homo sapiens (Human)	defense response to tumor cell [GO:0002357]; negative regulation of cell population proliferation [GO:0008285]; spermatogenesis [GO:0007283]	alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; tubulin binding [GO:0015631]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0002357; GO:0005737; GO:0005829; GO:0005929; GO:0007283; GO:0008285; GO:0015631; GO:0043014; GO:0048487
GN000386	GN000386.1	Q58CQ5	32.6	814	926	728	1.33e-80	279	ANKZ1_BOVIN	tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1)	Bos taurus (Bovine)	cellular response to hydrogen peroxide [GO:0070301]; ERAD pathway [GO:0036503]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; rescue of stalled cytosolic ribosome [GO:0072344]	catalytic activity, acting on a tRNA [GO:0140101]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]	GO:0004521; GO:0005737; GO:0006515; GO:0036503; GO:0070301; GO:0072344; GO:0140101
GN000387	GN000387.1	Q6DHI5	72.3	155	190	305	1.30e-77	237	SIR5_DANRE	NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5)	Danio rerio (Zebrafish) (Brachydanio rerio)	peptidyl-lysine demalonylation [GO:0036047]; peptidyl-lysine desuccinylation [GO:0036049]; protein desuccinylation [GO:0036048]; regulation of ketone biosynthetic process [GO:0010566]	acyl binding [GO:0000035]; heterocyclic compound binding [GO:1901363]; histone deacetylase activity, NAD-dependent [GO:0017136]; NAD+ binding [GO:0070403]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-succinyllysine desuccinylase activity [GO:0036055]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0000035; GO:0005634; GO:0005739; GO:0005759; GO:0005829; GO:0008270; GO:0010566; GO:0017136; GO:0036047; GO:0036048; GO:0036049; GO:0036054; GO:0036055; GO:0061697; GO:0070403; GO:1901363
GN000388	GN000388.1	P22770	30.5	305	405	502	9.74e-38	145	ACHA7_CHICK	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005737; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030424; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043204; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN000389	GN000389.1	Q5ZM41	27.1	863	815	927	1.15e-74	265	TEX10_CHICK	Testis-expressed protein 10 homolog	Gallus gallus (Chicken)			MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730; GO:0071339
GN000397	GN000397.1	Q99728	39.2	102	130	777	3.43e-17	79.7	BARD1_HUMAN	BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)	Homo sapiens (Human)	cellular response to ionizing radiation [GO:0071479]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; homologous recombination [GO:0035825]; mitotic G2/M transition checkpoint [GO:0044818]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle [GO:0045786]; negative regulation of mRNA 3'-end processing [GO:0031441]; negative regulation of protein export from nucleus [GO:0046826]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein catabolic process [GO:0045732]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of DNA damage checkpoint [GO:2000001]; regulation of DNA repair [GO:0006282]; regulation of phosphorylation [GO:0042325]; regulation of transcription by RNA polymerase II [GO:0006357]; tissue homeostasis [GO:0001894]	histone H2AK127 ubiquitin ligase activity [GO:0140863]; histone H2AK129 ubiquitin ligase activity [GO:0140864]; kinase binding [GO:0019900]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-modified histone reader activity [GO:0061649]; ubiquitin-protein transferase activity [GO:0004842]	BRCA1-A complex [GO:0070531]; BRCA1-B complex [GO:0070532]; BRCA1-BARD1 complex [GO:0031436]; BRCA1-C complex [GO:0070533]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000152; GO:0001894; GO:0003723; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0006282; GO:0006338; GO:0006357; GO:0006974; GO:0016567; GO:0016607; GO:0019900; GO:0031436; GO:0031441; GO:0035825; GO:0042325; GO:0042803; GO:0043065; GO:0043066; GO:0044818; GO:0045732; GO:0045786; GO:0046826; GO:0046982; GO:0051726; GO:0061630; GO:0061649; GO:0070531; GO:0070532; GO:0070533; GO:0071479; GO:0085020; GO:0110025; GO:0140863; GO:0140864; GO:2000001
GN000399	GN000399.1	P54131	30.1	272	347	499	7.91e-27	114	ACHA7_BOVIN	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Bos taurus (Bovine)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN000401	GN000401.1	Q6P963	71.3	80	198	303	1.90e-30	116	GLO2_DANRE	Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)	Danio rerio (Zebrafish) (Brachydanio rerio)	glutathione metabolic process [GO:0006749]; methylglyoxal catabolic process [GO:0051596]	hydroxyacylglutathione hydrolase activity [GO:0004416]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004416; GO:0005737; GO:0005739; GO:0005759; GO:0006749; GO:0051596
GN000404	GN000404.1	Q864U1	30.6	216	2459	1849	1.05e-21	107	BRCA1_BOVIN	Breast cancer type 1 susceptibility protein homolog (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BRCA1)	Bos taurus (Bovine)	chordate embryonic development [GO:0043009]; DNA repair [GO:0006281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of fatty acid biosynthetic process [GO:0045717]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoubiquitination [GO:0051865]; protein K6-linked ubiquitination [GO:0085020]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; RNA polymerase binding [GO:0070063]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	BRCA1-A complex [GO:0070531]; BRCA1-BARD1 complex [GO:0031436]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; intracellular organelle lumen [GO:0070013]; nucleus [GO:0005634]	GO:0003677; GO:0003713; GO:0004842; GO:0005634; GO:0005694; GO:0005737; GO:0006281; GO:0006357; GO:0007095; GO:0008270; GO:0031436; GO:0043009; GO:0045717; GO:0045893; GO:0045944; GO:0051865; GO:0061630; GO:0070013; GO:0070063; GO:0070531; GO:0085020
GN000405	GN000405.1	Q8K2I3	36.6	399	360	535	3.28e-85	270	FMO2_MOUSE	Dimethylaniline monooxygenase [N-oxide-forming] 2 (EC 1.14.13.-) (Dimethylaniline oxidase 2) (Pulmonary flavin-containing monooxygenase 2) (FMO 2)	Mus musculus (Mouse)	energy homeostasis [GO:0097009]; NADP+ metabolic process [GO:0006739]; negative regulation of fatty acid oxidation [GO:0046322]; oxygen metabolic process [GO:0072592]; sulfur oxidation [GO:0019417]; toxin metabolic process [GO:0009404]; xenobiotic metabolic process [GO:0006805]	flavin adenine dinucleotide binding [GO:0050660]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0004497; GO:0004499; GO:0005789; GO:0006739; GO:0006805; GO:0009404; GO:0016020; GO:0019417; GO:0046322; GO:0050660; GO:0050661; GO:0072592; GO:0097009
GN000408	GN000408.1	Q2PZI1	52.2	657	707	675	9.39e-229	656	D19L1_HUMAN	Protein C-mannosyl-transferase DPY19L1 (EC 2.4.1.-) (Dpy-19-like protein 1) (Protein dpy-19 homolog 1)	Homo sapiens (Human)		mannosyltransferase activity [GO:0000030]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0000030; GO:0005789; GO:0016020
GN000411	GN000411.1	Q805R1	27.4	380	403	440	3.56e-37	143	GCNT3_BHV4L	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M)	Bovine herpesvirus 4 (strain LVR140) (BoHV-4) (Movar virus)		acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0047225]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]	host cell Golgi membrane [GO:0044178]; membrane [GO:0016020]	GO:0003829; GO:0008109; GO:0016020; GO:0044178; GO:0047225
GN000413	GN000413.1	A8WG43	34.5	345	353	354	1.26e-36	138	CCD89_DANRE	Coiled-coil domain-containing protein 89 (Bc8 orange-interacting protein)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN000414	GN000414.1	Q802U2	41.5	513	510	876	3.27e-124	387	MIOS_DANRE	GATOR2 complex protein MIOS	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; heart contraction [GO:0060047]; positive regulation of TORC1 signaling [GO:1904263]; venous blood vessel development [GO:0060841]		cytoplasm [GO:0005737]; GATOR2 complex [GO:0061700]; lysosomal membrane [GO:0005765]	GO:0005737; GO:0005765; GO:0031669; GO:0034198; GO:0060047; GO:0060841; GO:0061700; GO:1904263
GN000415	GN000415.1	P18613	37.2	164	179	186	1.63e-26	102	RAPA_DICDI	Ras-related protein rapA (EC 3.6.5.2) (Ras-related protein rap-1)	Dictyostelium discoideum (Social amoeba)	actomyosin structure organization [GO:0031032]; cellular response to cGMP [GO:0071321]; chemotaxis [GO:0006935]; hyperosmotic response [GO:0006972]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mitotic cytokinesis [GO:0000281]; negative regulation of cell migration [GO:0030336]; negative regulation of pinocytosis [GO:0048550]; nucleus organization [GO:0006997]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of phagocytosis [GO:0050766]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of TORC2 signaling [GO:1904515]; Rap protein signal transduction [GO:0032486]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of cell-cell adhesion [GO:0022407]; regulation of myosin II filament assembly [GO:0043520]; regulation of Ras protein signal transduction [GO:0046578]; response to cold [GO:0009409]; small GTPase-mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; guanylate cyclase activator activity [GO:0030250]; small GTPase binding [GO:0031267]	cell cortex [GO:0005938]; cell pole [GO:0060187]; cytosol [GO:0005829]; extracellular matrix [GO:0031012]; leading edge membrane [GO:0031256]; lipid droplet [GO:0005811]; pathogen-containing vacuole [GO:0140220]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GO:0000281; GO:0003924; GO:0003925; GO:0005096; GO:0005525; GO:0005811; GO:0005829; GO:0005886; GO:0005938; GO:0006935; GO:0006972; GO:0006997; GO:0007264; GO:0009409; GO:0022407; GO:0030250; GO:0030336; GO:0030587; GO:0030833; GO:0030838; GO:0031012; GO:0031032; GO:0031256; GO:0031267; GO:0031982; GO:0032486; GO:0032956; GO:0043520; GO:0045335; GO:0046578; GO:0048550; GO:0050766; GO:0060187; GO:0071321; GO:0140220; GO:1900026; GO:1902850; GO:1904515
GN000416	GN000416.1	A0A345BJN8	29.3	229	519	919	3.31e-20	98.2	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN000422	GN000422.1	P82186	66.5	173	183	181	7.73e-88	258	GUN_MYTED	Endoglucanase (EC 3.2.1.4) (CMCase) (Cellulase) (Endo-1,4-beta-glucanase)	Mytilus edulis (Blue mussel)		cellulase activity [GO:0008810]		GO:0008810
GN000424	GN000424.1	Q8K4F6	40.5	430	555	465	7.17e-87	279	NSUN5_MOUSE	28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein homolog)	Mus musculus (Mouse)	cerebral cortex development [GO:0021987]; cognition [GO:0050890]; corpus callosum development [GO:0022038]; oligodendrocyte development [GO:0014003]; positive regulation of translation [GO:0045727]; regulation of myelination [GO:0031641]; rRNA base methylation [GO:0070475]	rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005730; GO:0009383; GO:0014003; GO:0021987; GO:0022038; GO:0031641; GO:0045727; GO:0050890; GO:0070475
GN000425	GN000425.1	Q9WYP5	31.3	336	344	334	1.39e-47	166	IOLG_THEMA	Myo-inositol 2-dehydrogenase (EC 1.1.1.18)	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	inositol metabolic process [GO:0006020]	inositol 2-dehydrogenase (NAD+) activity [GO:0050112]; nucleotide binding [GO:0000166]		GO:0000166; GO:0006020; GO:0050112
GN000430	GN000430.1	P51448	28.6	458	518	523	1.71e-26	116	RORA_MOUSE	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha)	Mus musculus (Mouse)	angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to sterol [GO:0036315]; cellular response to tumor necrosis factor [GO:0071356]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellar Purkinje cell differentiation [GO:0021702]; cGMP metabolic process [GO:0046068]; cholesterol homeostasis [GO:0042632]; circadian regulation of gene expression [GO:0032922]; intracellular receptor signaling pathway [GO:0030522]; muscle cell differentiation [GO:0042692]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of inflammatory response [GO:0050728]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucose metabolic process [GO:0010906]; regulation of macrophage activation [GO:0043030]; regulation of smoothened signaling pathway [GO:0008589]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription by RNA polymerase II [GO:0006357]; T-helper 17 cell differentiation [GO:0072539]; triglyceride homeostasis [GO:0070328]; xenobiotic metabolic process [GO:0006805]	beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; ligand-modulated transcription factor activity [GO:0098531]; nuclear receptor activity [GO:0004879]; oxysterol binding [GO:0008142]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]; transcription coregulator binding [GO:0001221]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000977; GO:0000978; GO:0000981; GO:0001221; GO:0001222; GO:0001223; GO:0001525; GO:0003677; GO:0003700; GO:0004879; GO:0005634; GO:0005654; GO:0005730; GO:0006355; GO:0006357; GO:0006805; GO:0006809; GO:0008013; GO:0008142; GO:0008270; GO:0008589; GO:0010575; GO:0010906; GO:0019218; GO:0021702; GO:0021930; GO:0030522; GO:0032922; GO:0036315; GO:0042632; GO:0042692; GO:0042752; GO:0042753; GO:0043030; GO:0043124; GO:0043565; GO:0045599; GO:0045893; GO:0045944; GO:0046068; GO:0050728; GO:0070328; GO:0071347; GO:0071356; GO:0071456; GO:0072539; GO:0098531
GN000434	GN000434.1	Q9Y5X5	30.4	306	357	522	1.61e-38	147	NPFF2_HUMAN	Neuropeptide FF receptor 2 (G protein-coupled receptor 74) (G protein-coupled receptor HLWAR77) (Neuropeptide G protein-coupled receptor)	Homo sapiens (Human)	cellular response to hormone stimulus [GO:0032870]; detection of abiotic stimulus [GO:0009582]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; regulation of MAPK cascade [GO:0043408]	G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007186; GO:0007218; GO:0008188; GO:0009582; GO:0031628; GO:0032870; GO:0043408
GN000435	GN000435.1	Q9WVD0	27.0	211	209	383	2.07e-15	77.0	NPY1R_CAVPO	Neuropeptide Y receptor type 1 (NPY1-R)	Cavia porcellus (Guinea pig)	positive regulation of eating behavior [GO:1904000]	neuropeptide binding [GO:0042923]; neuropeptide Y receptor activity [GO:0004983]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]	GO:0004983; GO:0005886; GO:0042923; GO:0043005; GO:1904000
GN000437	GN000437.1	Q9DA19	60.8	120	128	450	1.16e-41	145	CIR1_MOUSE	Corepressor of RBPJ and splicing regulator (CBF1-interacting corepressor) (Corepressor interacting with RBPJ 1)	Mus musculus (Mouse)	in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]	histone deacetylase binding [GO:0042826]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]	centrosome [GO:0005813]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0000122; GO:0001701; GO:0003714; GO:0005634; GO:0005681; GO:0005813; GO:0016607; GO:0019901; GO:0032991; GO:0042826; GO:0044877; GO:0045892; GO:0045944; GO:0071006
GN000442	GN000442.1	O43175	56.5	372	489	533	1.46e-136	407	SERA_HUMAN	D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37)	Homo sapiens (Human)	brain development [GO:0007420]; L-serine biosynthetic process [GO:0006564]	(R)-2-hydroxyglutarate (NAD+) dehydrogenase activity [GO:0120568]; electron transfer activity [GO:0009055]; L-malate dehydrogenase (NAD+) activity [GO:0030060]; NAD binding [GO:0051287]; phosphoglycerate dehydrogenase activity [GO:0004617]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0004617; GO:0005829; GO:0006564; GO:0007420; GO:0009055; GO:0030060; GO:0051287; GO:0070062; GO:0120568
GN000443	GN000443.1	O57321	60.1	333	350	543	5.16e-125	372	EAA1_AMBTI	Excitatory amino acid transporter 1 (SEAAT1) (Sodium-dependent glutamate/aspartate transporter) (GLAST)	Ambystoma tigrinum (Eastern tiger salamander)	chloride transmembrane transport [GO:1902476]; D-aspartate import across plasma membrane [GO:0070779]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamate import across plasma membrane [GO:0098712]; potassium ion transmembrane transport [GO:0071805]	glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	plasma membrane [GO:0005886]	GO:0005314; GO:0005886; GO:0015175; GO:0015501; GO:0070779; GO:0071805; GO:0098712; GO:0140009; GO:1902476
GN000444	GN000444.1	Q8JZR4	52.3	132	184	559	4.12e-32	124	EAA5_MOUSE	Excitatory amino acid transporter 5 (Solute carrier family 1 member 7)	Mus musculus (Mouse)	chloride transmembrane transport [GO:1902476]; L-glutamate transmembrane transport [GO:0015813]; monoatomic anion transmembrane transport [GO:0098656]; neurotransmitter uptake [GO:0001504]	extracellularly glutamate-gated chloride channel activity [GO:0008068]; glutamate:sodium symporter activity [GO:0015501]; L-glutamate transmembrane transporter activity [GO:0005313]; monoatomic anion transmembrane transporter activity [GO:0008509]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	axon terminus [GO:0043679]; glutamatergic synapse [GO:0098978]; photoreceptor cell terminal bouton [GO:1990796]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]	GO:0001504; GO:0005313; GO:0005886; GO:0008068; GO:0008509; GO:0015175; GO:0015501; GO:0015813; GO:0042734; GO:0043679; GO:0045211; GO:0097060; GO:0098656; GO:0098978; GO:1902476; GO:1990796
GN000445	GN000445.1	Q9I8C7	46.8	265	430	452	9.41e-78	251	ACH10_CHICK	Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0050910; GO:0097060; GO:1902495
GN000452	GN000452.1	A0A1B0GVB3	40.9	127	278	256	4.37e-21	92.8	CG078_HUMAN	Putative uncharacterized protein C7orf78	Homo sapiens (Human)				
GN000454	GN000454.1	Q08420	31.5	146	173	244	9.45e-09	56.2	SODE_RAT	Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) (Superoxide dismutase B)	Rattus norvegicus (Rat)	blood vessel diameter maintenance [GO:0097746]; nitric oxide metabolic process [GO:0046209]; removal of superoxide radicals [GO:0019430]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]	copper ion binding [GO:0005507]; molecular adaptor activity [GO:0060090]; superoxide dismutase activity [GO:0004784]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]	GO:0001666; GO:0004784; GO:0005507; GO:0005576; GO:0005634; GO:0005737; GO:0005794; GO:0006979; GO:0019430; GO:0031012; GO:0046209; GO:0046688; GO:0060090; GO:0097746
GN000456	GN000456.1	O73817	79.5	205	205	205	5.58e-122	346	PSB3_ONCMY	Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)	Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]	GO:0005634; GO:0005737; GO:0005839; GO:0019774; GO:0043161
GN000457	GN000457.1	P55214	31.2	269	387	303	2.36e-27	113	CASP7_MESAU	Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]	Mesocricetus auratus (Golden hamster)	defense response to bacterium [GO:0042742]; execution phase of apoptosis [GO:0097194]; lymphocyte apoptotic process [GO:0070227]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of plasma membrane repair [GO:1905686]; proteolysis [GO:0006508]	aspartic-type endopeptidase activity [GO:0004190]; cysteine-type endopeptidase activity [GO:0004197]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0003723; GO:0004190; GO:0004197; GO:0005576; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0042742; GO:0043525; GO:0070227; GO:0097194; GO:1905686
GN000462	GN000462.1	P20594	57.3	445	458	1047	1.50e-162	489	ANPRB_HUMAN	Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B)	Homo sapiens (Human)	activation of meiosis involved in egg activation [GO:0060466]; axonogenesis involved in innervation [GO:0060385]; blood vessel remodeling [GO:0001974]; bone growth [GO:0098868]; c-di-GMP signaling [GO:0061939]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to peptide [GO:1901653]; cGMP biosynthetic process [GO:0006182]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; chromosome organization [GO:0051276]; collateral sprouting [GO:0048668]; cumulus cell differentiation [GO:0001549]; digestive tract morphogenesis [GO:0048546]; endochondral ossification [GO:0001958]; epidermal growth factor receptor signaling pathway [GO:0007173]; execution phase of apoptosis [GO:0097194]; female genitalia development [GO:0030540]; gastric emptying [GO:0035483]; genitalia morphogenesis [GO:0035112]; growth plate cartilage development [GO:0003417]; limb morphogenesis [GO:0035108]; lymph vessel development [GO:0001945]; MAPK cascade [GO:0000165]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; multicellular organism growth [GO:0035264]; neuron apoptotic process [GO:0051402]; neuronal action potential [GO:0019228]; post-anal tail morphogenesis [GO:0036342]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; response to fibroblast growth factor [GO:0071774]; response to luteinizing hormone [GO:0034699]; response to salt [GO:1902074]; sensory perception of sound [GO:0007605]; smooth muscle tissue development [GO:0048745]; spermatogenesis [GO:0007283]; startle response [GO:0001964]; vacuole organization [GO:0007033]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]; vestibulocochlear nerve maturation [GO:0021647]; white fat cell differentiation [GO:0050872]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; identical protein binding [GO:0042802]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; protein kinase activity [GO:0004672]	cilium [GO:0005929]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0000165; GO:0001549; GO:0001570; GO:0001945; GO:0001958; GO:0001964; GO:0001974; GO:0002062; GO:0003417; GO:0004383; GO:0004672; GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0005929; GO:0006182; GO:0007033; GO:0007168; GO:0007173; GO:0007268; GO:0007283; GO:0007605; GO:0008217; GO:0016941; GO:0017046; GO:0019228; GO:0021647; GO:0030540; GO:0034699; GO:0035108; GO:0035112; GO:0035264; GO:0035483; GO:0035988; GO:0036342; GO:0042562; GO:0042802; GO:0043005; GO:0045202; GO:0048546; GO:0048668; GO:0048745; GO:0050872; GO:0051276; GO:0051402; GO:0060385; GO:0060466; GO:0061042; GO:0061939; GO:0071321; GO:0071774; GO:0097011; GO:0097194; GO:0098868; GO:1901653; GO:1902074; GO:1903537
GN000464	GN000464.1	P20594	52.8	369	453	1047	8.15e-115	364	ANPRB_HUMAN	Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B)	Homo sapiens (Human)	activation of meiosis involved in egg activation [GO:0060466]; axonogenesis involved in innervation [GO:0060385]; blood vessel remodeling [GO:0001974]; bone growth [GO:0098868]; c-di-GMP signaling [GO:0061939]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to peptide [GO:1901653]; cGMP biosynthetic process [GO:0006182]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; chromosome organization [GO:0051276]; collateral sprouting [GO:0048668]; cumulus cell differentiation [GO:0001549]; digestive tract morphogenesis [GO:0048546]; endochondral ossification [GO:0001958]; epidermal growth factor receptor signaling pathway [GO:0007173]; execution phase of apoptosis [GO:0097194]; female genitalia development [GO:0030540]; gastric emptying [GO:0035483]; genitalia morphogenesis [GO:0035112]; growth plate cartilage development [GO:0003417]; limb morphogenesis [GO:0035108]; lymph vessel development [GO:0001945]; MAPK cascade [GO:0000165]; meiotic cell cycle process involved in oocyte maturation [GO:1903537]; multicellular organism growth [GO:0035264]; neuron apoptotic process [GO:0051402]; neuronal action potential [GO:0019228]; post-anal tail morphogenesis [GO:0036342]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; response to fibroblast growth factor [GO:0071774]; response to luteinizing hormone [GO:0034699]; response to salt [GO:1902074]; sensory perception of sound [GO:0007605]; smooth muscle tissue development [GO:0048745]; spermatogenesis [GO:0007283]; startle response [GO:0001964]; vacuole organization [GO:0007033]; vascular wound healing [GO:0061042]; vasculogenesis [GO:0001570]; vestibulocochlear nerve maturation [GO:0021647]; white fat cell differentiation [GO:0050872]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; identical protein binding [GO:0042802]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; protein kinase activity [GO:0004672]	cilium [GO:0005929]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0000165; GO:0001549; GO:0001570; GO:0001945; GO:0001958; GO:0001964; GO:0001974; GO:0002062; GO:0003417; GO:0004383; GO:0004672; GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0005929; GO:0006182; GO:0007033; GO:0007168; GO:0007173; GO:0007268; GO:0007283; GO:0007605; GO:0008217; GO:0016941; GO:0017046; GO:0019228; GO:0021647; GO:0030540; GO:0034699; GO:0035108; GO:0035112; GO:0035264; GO:0035483; GO:0035988; GO:0036342; GO:0042562; GO:0042802; GO:0043005; GO:0045202; GO:0048546; GO:0048668; GO:0048745; GO:0050872; GO:0051276; GO:0051402; GO:0060385; GO:0060466; GO:0061042; GO:0061939; GO:0071321; GO:0071774; GO:0097011; GO:0097194; GO:0098868; GO:1901653; GO:1902074; GO:1903537
GN000470	GN000470.1	Q498J9	40.0	100	129	233	2.73e-16	75.1	MBLC1_XENLA	Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1)	Xenopus laevis (African clawed frog)	histone mRNA metabolic process [GO:0008334]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0008334; GO:0046872; GO:1900087
GN000471	GN000471.1	O14807	71.2	184	194	208	3.28e-91	268	RASM_HUMAN	Ras-related protein M-Ras (EC 3.6.5.2) (Ras-related protein R-Ras3)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; establishment or maintenance of cell polarity [GO:0007163]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of TOR signaling [GO:0032008]; Ras protein signal transduction [GO:0007265]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein phosphatase type 1 complex [GO:0000164]	GO:0000164; GO:0003924; GO:0003925; GO:0005525; GO:0005737; GO:0005886; GO:0007163; GO:0007265; GO:0030036; GO:0030742; GO:0032008; GO:0046579
GN000472	GN000472.1	Q9NVE5	38.1	936	1058	1235	2.09e-185	575	UBP40_HUMAN	Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.4.19.12) (Deubiquitinating enzyme 40) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40)	Homo sapiens (Human)	negative regulation of apoptotic process [GO:0043066]; protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]	GO:0004843; GO:0005737; GO:0016579; GO:0043066
GN000474	GN000474.1	Q66IB8	54.5	88	137	126	9.44e-32	112	CB076_DANRE	UPF0538 protein C2orf76 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)				
GN000476	GN000476.1	P86854	28.9	121	442	156	3.49e-09	58.9	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN000481	GN000481.1	Q02763	33.6	271	271	1124	1.44e-39	149	TIE2_HUMAN	Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)	Homo sapiens (Human)	angiogenesis [GO:0001525]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to mechanical stimulus [GO:0071260]; definitive hemopoiesis [GO:0060216]; endothelial cell proliferation [GO:0001935]; glomerulus vasculature development [GO:0072012]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of vascular permeability [GO:0043114]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; signaling receptor activity [GO:0038023]; transmembrane receptor protein kinase activity [GO:0019199]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001525; GO:0001935; GO:0001938; GO:0002040; GO:0004672; GO:0004713; GO:0004714; GO:0005524; GO:0005576; GO:0005886; GO:0005902; GO:0005911; GO:0005925; GO:0007166; GO:0007169; GO:0007267; GO:0007507; GO:0009925; GO:0009986; GO:0010595; GO:0016323; GO:0016324; GO:0016525; GO:0019199; GO:0032878; GO:0034446; GO:0035022; GO:0035025; GO:0038023; GO:0042802; GO:0043066; GO:0043114; GO:0043235; GO:0043410; GO:0045121; GO:0045766; GO:0048014; GO:0050728; GO:0051894; GO:0051897; GO:0060216; GO:0060347; GO:0070161; GO:0070374; GO:0071260; GO:0072012; GO:1902533; GO:2000351; GO:2000352
GN000482	GN000482.1	Q07263	25.2	326	402	495	3.01e-29	122	ACHA3_BOVIN	Neuronal acetylcholine receptor subunit alpha-3	Bos taurus (Bovine)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005783; GO:0005794; GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0035095; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060; GO:0098793; GO:0099171
GN000484	GN000484.1	P02637	54.3	175	179	176	2.31e-61	191	SCP_MIZYE	Sarcoplasmic calcium-binding protein (SCP)	Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis)		calcium ion binding [GO:0005509]		GO:0005509
GN000487	GN000487.1	P55102	32.8	137	372	426	3.10e-15	80.1	INHBA_HORSE	Inhibin beta A chain (Activin beta-A chain)	Equus caballus (Horse)	activin receptor signaling pathway [GO:0032924]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; eyelid development in camera-type eye [GO:0061029]; hair follicle development [GO:0001942]; hematopoietic progenitor cell differentiation [GO:0002244]; hemoglobin biosynthetic process [GO:0042541]; male gonad development [GO:0008584]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; odontogenesis [GO:0042476]; ovarian follicle development [GO:0001541]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of ovulation [GO:0060279]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone secretion [GO:0042701]; regulation of follicle-stimulating hormone secretion [GO:0046880]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]	activin A complex [GO:0043509]; extracellular region [GO:0005576]; inhibin A complex [GO:0043512]	GO:0001541; GO:0001942; GO:0002244; GO:0005125; GO:0005179; GO:0005576; GO:0006357; GO:0007178; GO:0008083; GO:0008285; GO:0008584; GO:0030308; GO:0032924; GO:0042476; GO:0042541; GO:0042701; GO:0043509; GO:0043512; GO:0045648; GO:0045893; GO:0045944; GO:0046880; GO:0060021; GO:0060279; GO:0061029; GO:2000134; GO:2001241
GN000488	GN000488.1	Q96GW7	34.9	126	152	911	2.78e-19	86.7	PGCB_HUMAN	Brevican core protein (Brain-enriched hyaluronan-binding protein) (BEHAB) (Chondroitin sulfate proteoglycan 7)	Homo sapiens (Human)	cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; skeletal system development [GO:0001501]; synapse maturation [GO:0060074]	hyaluronic acid binding [GO:0005540]	extracellular region [GO:0005576]; gel phase of interstitial matrix [GO:0140150]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; perineuronal net [GO:0072534]; synapse [GO:0045202]	GO:0001501; GO:0005540; GO:0005576; GO:0005796; GO:0007155; GO:0007417; GO:0016020; GO:0043202; GO:0045202; GO:0060074; GO:0072534; GO:0098978; GO:0140150
GN000489	GN000489.1	Q9VUC6	48.1	1115	1119	1183	2.31e-279	819	FRL_DROME	Formin-like protein (Formin related in leukocytes)	Drosophila melanogaster (Fruit fly)	axon extension [GO:0048675]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; mushroom body development [GO:0016319]; ommatidial rotation [GO:0016318]; regulation of cell shape [GO:0008360]	actin filament binding [GO:0051015]; GTPase binding [GO:0051020]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]	GO:0005829; GO:0008360; GO:0016318; GO:0016319; GO:0016477; GO:0030866; GO:0031267; GO:0048675; GO:0051015; GO:0051020
GN000491	GN000491.1	Q7ZVB2	55.9	476	490	508	1.12e-189	541	A9A1A_DANRE	4-trimethylaminobutyraldehyde dehydrogenase A (TMABA-DH) (TMABADH) (EC 1.2.1.47) (Aldehyde dehydrogenase family 9 member A1-A) (EC 1.2.1.3)	Danio rerio (Zebrafish) (Brachydanio rerio)	aldehyde metabolic process [GO:0006081]; carnitine biosynthetic process [GO:0045329]; protein homotetramerization [GO:0051289]	4-trimethylammoniobutyraldehyde dehydrogenase activity [GO:0047105]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aminobutyraldehyde dehydrogenase (NAD+) activity [GO:0019145]	cytosol [GO:0005829]	GO:0004029; GO:0005829; GO:0006081; GO:0019145; GO:0045329; GO:0047105; GO:0051289
GN000492	GN000492.1	Q09369	25.3	245	280	280	1.02e-15	78.6	AQP10_CAEEL	Putative aquaporin-10	Caenorhabditis elegans	innate immune response [GO:0045087]; intracellular water homeostasis [GO:0009992]	water channel activity [GO:0015250]	plasma membrane [GO:0005886]	GO:0005886; GO:0009992; GO:0015250; GO:0045087
GN000493	GN000493.1	G5CTG8	21.7	230	322	270	6.54e-10	62.4	AQP11_MILTA	Aquaporin-11 (AQP-11)	Milnesium tardigradum (Water bear) (Tardigrade)		channel activity [GO:0015267]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0005737; GO:0015267; GO:0016020
GN000500	GN000500.1	P93732	57.6	85	106	380	3.12e-28	108	PIP_ARATH	Proline iminopeptidase (PIP) (EC 3.4.11.5) (Prolyl aminopeptidase) (PAP)	Arabidopsis thaliana (Mouse-ear cress)	proteolysis [GO:0006508]; response to metal ion [GO:0010038]; response to salt [GO:1902074]; response to water deprivation [GO:0009414]	aminopeptidase activity [GO:0004177]	chloroplast [GO:0009507]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; secretory vesicle [GO:0099503]	GO:0004177; GO:0005737; GO:0005739; GO:0005829; GO:0006508; GO:0009414; GO:0009507; GO:0010038; GO:0099503; GO:1902074
GN000501	GN000501.1	O83041	69.4	49	50	321	1.41e-19	81.6	PIP_LEPBY	Probable proline iminopeptidase (PIP) (EC 3.4.11.5) (Prolyl aminopeptidase) (PAP)	Leptolyngbya boryana (Plectonema boryanum)	proteolysis [GO:0006508]	aminopeptidase activity [GO:0004177]	cytoplasm [GO:0005737]	GO:0004177; GO:0005737; GO:0006508
GN000502	GN000502.1	P54131	29.3	263	347	499	1.54e-34	135	ACHA7_BOVIN	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Bos taurus (Bovine)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN000503	GN000503.1	P54131	30.1	256	359	499	9.44e-33	130	ACHA7_BOVIN	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Bos taurus (Bovine)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN000504	GN000504.1	O83041	63.0	311	319	321	5.85e-153	434	PIP_LEPBY	Probable proline iminopeptidase (PIP) (EC 3.4.11.5) (Prolyl aminopeptidase) (PAP)	Leptolyngbya boryana (Plectonema boryanum)	proteolysis [GO:0006508]	aminopeptidase activity [GO:0004177]	cytoplasm [GO:0005737]	GO:0004177; GO:0005737; GO:0006508
GN000505	GN000505.1	Q9VGJ5	44.5	137	225	195	1.53e-25	101	FER3_DROME	Protein Fer3 (Basic helix-loop-helix protein N-twist) (Nephew of atonal 3) (Neuronal twist)	Drosophila melanogaster (Fruit fly)	developmental process [GO:0032502]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0003700; GO:0005634; GO:0006355; GO:0006357; GO:0032502; GO:0045892; GO:0046983
GN000506	GN000506.1	Q9VGJ5	39.0	172	225	195	2.49e-23	95.9	FER3_DROME	Protein Fer3 (Basic helix-loop-helix protein N-twist) (Nephew of atonal 3) (Neuronal twist)	Drosophila melanogaster (Fruit fly)	developmental process [GO:0032502]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0003700; GO:0005634; GO:0006355; GO:0006357; GO:0032502; GO:0045892; GO:0046983
GN000507	GN000507.1	Q923Z4	66.7	72	208	168	8.20e-24	95.9	FER3L_MOUSE	Fer3-like protein (Basic helix-loop-helix protein N-twist) (Nephew of atonal 3) (Neuronal twist)	Mus musculus (Mouse)	cell development [GO:0048468]; developmental process [GO:0032502]; floor plate development [GO:0033504]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]	GO:0000122; GO:0000977; GO:0000981; GO:0001227; GO:0005634; GO:0006357; GO:0032502; GO:0033504; GO:0045892; GO:0046983; GO:0048468; GO:0050767; GO:1990837
GN000508	GN000508.1	Q8HZY8	34.8	607	622	603	1.38e-92	300	CC148_MACFA	Coiled-coil domain-containing protein 148	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)				
GN000510	GN000510.1	Q9UKG9	46.3	594	624	612	3.89e-182	531	OCTC_HUMAN	Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137)	Homo sapiens (Human)	carnitine metabolic process [GO:0009437]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid metabolic process [GO:0006631]; generation of precursor metabolites and energy [GO:0006091]; medium-chain fatty acid metabolic process [GO:0051791]	carnitine O-octanoyltransferase activity [GO:0008458]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0005777; GO:0005782; GO:0005829; GO:0006091; GO:0006631; GO:0006635; GO:0008458; GO:0009437; GO:0015936; GO:0033540; GO:0051791
GN000511	GN000511.1	Q6DBY9	27.3	220	275	420	3.23e-10	63.5	CHST1_DANRE	Carbohydrate sulfotransferase 1 (EC 2.8.2.21) (Keratan sulfate Gal-6 sulfotransferase) (KS6ST) (KSGal6ST) (KSST)	Danio rerio (Zebrafish) (Brachydanio rerio)	carbohydrate metabolic process [GO:0005975]; keratan sulfate proteoglycan metabolic process [GO:0042339]; N-acetylglucosamine metabolic process [GO:0006044]; sulfur compound metabolic process [GO:0006790]	keratan sulfotransferase activity [GO:0045130]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]	Golgi membrane [GO:0000139]	GO:0000139; GO:0001517; GO:0005975; GO:0006044; GO:0006790; GO:0042339; GO:0045130
GN000513	GN000513.1	V5NAL9	27.3	388	491	899	4.37e-18	91.3	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN000514	GN000514.1	Q9EPW9	30.9	136	213	795	6.42e-15	76.3	TLR6_MOUSE	Toll-like receptor 6 (CD antigen CD286)	Mus musculus (Mouse)	antibacterial innate immune response [GO:0140367]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; detection of diacyl bacterial lipopeptide [GO:0042496]; inflammatory response [GO:0006954]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide metabolic process [GO:0046209]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macrophage activation [GO:0043032]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; response to bacterial lipoprotein [GO:0032493]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	diacyl lipopeptide binding [GO:0042498]; identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; lipopolysaccharide immune receptor activity [GO:0001875]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	GO:0001774; GO:0001875; GO:0002224; GO:0002755; GO:0004888; GO:0005102; GO:0005794; GO:0005886; GO:0006954; GO:0010628; GO:0030670; GO:0032493; GO:0032717; GO:0032720; GO:0032731; GO:0032735; GO:0032755; GO:0034136; GO:0035355; GO:0035663; GO:0035666; GO:0038023; GO:0038124; GO:0042496; GO:0042498; GO:0042802; GO:0043032; GO:0043123; GO:0043235; GO:0043507; GO:0045121; GO:0045429; GO:0046209; GO:0046982; GO:0050729; GO:0071723; GO:0071726; GO:0140052; GO:0140367; GO:1900017; GO:1900227; GO:1903428; GO:1904646; GO:2001238
GN000516	GN000516.1	Q0ZUL9	26.7	337	812	789	1.13e-17	91.7	TLR6_DASNO	Toll-like receptor 6 (CD antigen CD286)	Dasypus novemcinctus (Nine-banded armadillo)	cellular response to diacyl bacterial lipopeptide [GO:0071726]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; toll-like receptor signaling pathway [GO:0002224]	identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	GO:0002224; GO:0004888; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0030670; GO:0032731; GO:0035355; GO:0035663; GO:0042802; GO:0045121; GO:0071723; GO:0071726; GO:1900227
GN000519	GN000519.1	Q965M2	27.3	150	180	881	4.77e-09	58.2	SMA10_CAEEL	Leucine-rich repeats and immunoglobulin-like domains protein sma-10	Caenorhabditis elegans	positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of mesodermal cell fate specification [GO:0042661]; transforming growth factor beta receptor signaling pathway [GO:0007179]	signaling receptor activity [GO:0038023]; type I transforming growth factor beta receptor binding [GO:0034713]; type II transforming growth factor beta receptor binding [GO:0005114]	cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886]	GO:0005114; GO:0005886; GO:0007179; GO:0030511; GO:0030659; GO:0034713; GO:0038023; GO:0040018; GO:0042661
GN000525	GN000525.1	Q7JK24	32.7	245	263	326	2.68e-41	147	B3GT1_GORGO	Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)	Gorilla gorilla gorilla (Western lowland gorilla)	glucosylceramide metabolic process [GO:0006678]; glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006678; GO:0008499; GO:0009101; GO:0009312
GN000531	GN000531.1	P17164	49.1	316	320	462	9.06e-130	380	FUCO_RAT	Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1)	Rattus norvegicus (Rat)	fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]	alpha-L-fucosidase activity [GO:0004560]; carbohydrate binding [GO:0030246]; fucosidase activity [GO:0015928]	lysosome [GO:0005764]	GO:0004560; GO:0005764; GO:0006004; GO:0015928; GO:0016139; GO:0030246
GN000532	GN000532.1	Q5RFI5	43.9	139	163	465	8.76e-36	132	FUCO2_PONAB	Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]	alpha-L-fucosidase activity [GO:0004560]	azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]	GO:0004560; GO:0005576; GO:0006004; GO:0016139; GO:0035578
GN000534	GN000534.1	Q25414	52.6	418	404	509	1.69e-130	387	5HTR_LYMST	5-hydroxytryptamine receptor (5-HT receptor) (Serotonin receptor)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; positive regulation of MAPK cascade [GO:0043410]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0043410; GO:0071880
GN000541	GN000541.1	Q8WVJ9	65.0	143	183	160	7.27e-48	156	TWST2_HUMAN	Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1)	Homo sapiens (Human)	developmental process [GO:0032502]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of cell migration [GO:0030335]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006357; GO:0030335; GO:0032502; GO:0045668; GO:0045892; GO:0046983
GN000544	GN000544.1	P13903	74.0	96	187	166	5.19e-40	136	TWIST_XENLA	Twist-related protein (T18) (X-twist)	Xenopus laevis (African clawed frog)	developmental process [GO:0032502]; neural crest formation [GO:0014029]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0014029; GO:0032502; GO:0046983
GN000546	GN000546.1	Q6AYB3	62.0	50	105	284	4.37e-13	66.2	ISY1_RAT	Pre-mRNA-splicing factor ISY1 homolog	Rattus norvegicus (Rat)	generation of catalytic spliceosome for second transesterification step [GO:0000350]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]		catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0000350; GO:0000389; GO:0000398; GO:0000974; GO:0005634; GO:0016607; GO:0071006; GO:0071013; GO:0071014; GO:0071020
GN000548	GN000548.1	Q5F356	60.6	363	833	405	2.60e-135	411	PI42A_CHICK	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(5)P-4-kinase isoform 2-alpha)	Gallus gallus (Chicken)	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [GO:1902635]; autophagosome-lysosome fusion [GO:0061909]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; regulation of autophagy [GO:0010506]; vesicle-mediated cholesterol transport [GO:0090119]	1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005737; GO:0005764; GO:0005829; GO:0005886; GO:0010506; GO:0016308; GO:0016309; GO:0042803; GO:0046488; GO:0046854; GO:0061909; GO:0090119; GO:1902635
GN000549	GN000549.1	Q28BT8	72.1	251	254	639	4.10e-134	395	DUS3L_XENTR	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.89) (mRNA-dihydrouridine synthase DUS3L) (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	regulation of translation [GO:0006417]; tRNA dihydrouridine synthesis [GO:0002943]	flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; mRNA dihydrouridine synthase activity [GO:0106414]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine47 synthase activity [GO:0102265]		GO:0002943; GO:0006417; GO:0017150; GO:0046872; GO:0050660; GO:0102265; GO:0106414
GN000550	GN000550.1	P08684	40.7	425	473	503	7.40e-101	314	CP3A4_HUMAN	Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55)	Homo sapiens (Human)	aflatoxin metabolic process [GO:0046222]; alkaloid catabolic process [GO:0009822]; cholesterol metabolic process [GO:0008203]; estrogen metabolic process [GO:0008210]; lipid hydroxylation [GO:0002933]; lipid metabolic process [GO:0006629]; long-chain fatty acid biosynthetic process [GO:0042759]; monoterpenoid metabolic process [GO:0016098]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; steroid metabolic process [GO:0008202]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	1,8-cineole 2-exo-monooxygenase activity [GO:0102320]; 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity [GO:0062181]; anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; arachidonate 14,15-epoxygenase activity [GO:0008404]; caffeine oxidase activity [GO:0034875]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; quinine 3-monooxygenase activity [GO:0050591]; retinoic acid 4-hydroxylase activity [GO:0008401]; steroid binding [GO:0005496]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]; vitamin D 24-hydroxylase activity [GO:0070576]; vitamin D 25-hydroxylase activity [GO:0030343]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	GO:0002933; GO:0004497; GO:0005496; GO:0005506; GO:0005737; GO:0005789; GO:0006629; GO:0006706; GO:0006805; GO:0008202; GO:0008203; GO:0008210; GO:0008395; GO:0008401; GO:0008404; GO:0009822; GO:0016098; GO:0016491; GO:0016712; GO:0019825; GO:0019899; GO:0020037; GO:0030343; GO:0034875; GO:0042178; GO:0042359; GO:0042369; GO:0042572; GO:0042573; GO:0042759; GO:0043231; GO:0046222; GO:0050591; GO:0050649; GO:0062181; GO:0062187; GO:0062188; GO:0062189; GO:0070576; GO:0070989; GO:0101020; GO:0101021; GO:0102320
GN000551	GN000551.1	Q3MHZ8	33.7	374	367	355	5.16e-54	184	LEG9_BOVIN	Galectin-9 (Gal-9)	Bos taurus (Bovine)	negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of type II interferon production [GO:0032689]; positive regulation of gene expression [GO:0010628]	carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936]	cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0005576; GO:0005634; GO:0005829; GO:0010628; GO:0016936; GO:0030246; GO:0032689; GO:2000562
GN000553	GN000553.1	Q9WU62	41.5	123	592	880	6.85e-20	97.8	INCE_MOUSE	Inner centromere protein	Mus musculus (Mouse)	chromosome segregation [GO:0007059]; meiotic spindle midzone assembly [GO:0051257]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of protein phosphorylation [GO:0001934]	molecular function activator activity [GO:0140677]	central element [GO:0000801]; chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; lateral element [GO:0000800]; meiotic spindle midzone [GO:1990385]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; synaptonemal complex [GO:0000795]	GO:0000278; GO:0000281; GO:0000775; GO:0000776; GO:0000795; GO:0000800; GO:0000801; GO:0001934; GO:0005634; GO:0005654; GO:0005721; GO:0005819; GO:0005829; GO:0007052; GO:0007059; GO:0010369; GO:0015630; GO:0016604; GO:0030496; GO:0032133; GO:0032991; GO:0051256; GO:0051257; GO:0051310; GO:0090267; GO:0140677; GO:1901970; GO:1902425; GO:1903490; GO:1990385
GN000554	GN000554.1	A0A913XCT1	27.1	303	681	546	1.02e-11	71.6	CGLR_EXADI	Cyclic GMP-AMP synthase-like receptor (Ep-cGLR) (EC 2.7.7.86)	Exaiptasia diaphana (Tropical sea anemone) (Aiptasia pulchella)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN000556	GN000556.1	Q99KR8	51.7	259	269	461	5.55e-106	318	FUCO2_MOUSE	Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2)	Mus musculus (Mouse)	fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]; regulation of entry of bacterium into host cell [GO:2000535]; response to bacterium [GO:0009617]	alpha-L-fucosidase activity [GO:0004560]	extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0004560; GO:0005576; GO:0005764; GO:0006004; GO:0009617; GO:0016139; GO:2000535
GN000562	GN000562.1	E1BD59	23.6	348	477	732	5.72e-16	84.3	TRI56_BOVIN	E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (Tripartite motif-containing protein 56)	Bos taurus (Bovine)	defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; response to type I interferon [GO:0034340]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0006513; GO:0008270; GO:0032728; GO:0034340; GO:0045087; GO:0051607; GO:0060340; GO:0061630; GO:0070534
GN000566	GN000566.1	Q6PFY8	23.9	343	467	580	4.45e-18	90.5	TRI45_MOUSE	E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99) (Tripartite motif-containing protein 45)	Mus musculus (Mouse)	bone development [GO:0060348]; inflammatory response [GO:0006954]; negative regulation of inflammatory response [GO:0050728]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006954; GO:0008270; GO:0043161; GO:0045171; GO:0050728; GO:0060348; GO:0061630; GO:0070936
GN000567	GN000567.1	Q9C040	22.5	449	477	744	1.86e-16	85.9	TRIM2_HUMAN	Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2)	Homo sapiens (Human)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0043161; GO:0043523; GO:0061630
GN000568	GN000568.1	Q3MSM3	54.6	509	547	535	1.72e-190	547	SSDH_HYLLA	Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)	Hylobates lar (Lar gibbon) (White-handed gibbon)	central nervous system development [GO:0007417]; GABA catabolic process [GO:0009450]; succinate metabolic process [GO:0006105]	identical protein binding [GO:0042802]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]	mitochondrion [GO:0005739]	GO:0004777; GO:0005739; GO:0006105; GO:0007417; GO:0009450; GO:0042802
GN000573	GN000573.1	P46098	32.3	167	243	478	3.12e-15	77.8	5HT3A_HUMAN	5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor)	Homo sapiens (Human)	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; serotonin receptor signaling pathway [GO:0007210]; serotonin-gated cation-selective signaling pathway [GO:0140227]; transmembrane transport [GO:0055085]	identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; serotonin binding [GO:0051378]; serotonin-gated monoatomic cation channel activity [GO:0022850]	cleavage furrow [GO:0032154]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; serotonin-activated cation-selective channel complex [GO:1904602]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495]	GO:0005886; GO:0006816; GO:0007210; GO:0022850; GO:0032154; GO:0034220; GO:0042802; GO:0043005; GO:0045202; GO:0045211; GO:0051378; GO:0055085; GO:0099507; GO:0140227; GO:1902495; GO:1904602
GN000574	GN000574.1	Q5IS76	35.0	80	84	494	2.14e-12	63.9	ACHA6_PANTR	Neuronal acetylcholine receptor subunit alpha-6	Pan troglodytes (Chimpanzee)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0014059; GO:0015464; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN000577	GN000577.1	Q56R14	23.6	436	494	1091	1.94e-16	86.3	TRI33_XENLA	E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)	Xenopus laevis (African clawed frog)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0008270; GO:0016567; GO:0061630
GN000578	GN000578.1	Q5F3W2	66.8	196	213	225	2.35e-95	280	INSI2_CHICK	Insulin-induced gene 2 protein (INSIG-2)	Gallus gallus (Chicken)	cellular response to insulin stimulus [GO:0032869]; cholesterol biosynthetic process [GO:0006695]; SREBP signaling pathway [GO:0032933]; SREBP-SCAP complex retention in endoplasmic reticulum [GO:0036316]	oxysterol binding [GO:0008142]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SREBP-SCAP-Insig complex [GO:0032937]	GO:0005783; GO:0005789; GO:0006695; GO:0008142; GO:0032869; GO:0032933; GO:0032937; GO:0036316
GN000579	GN000579.1	P79782	63.0	100	113	183	4.75e-32	114	TCF15_CHICK	Transcription factor 15 (TCF-15) (Paraxis) (Protein bHLH-EC2)	Gallus gallus (Chicken)	developmental process [GO:0032502]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell population maintenance [GO:0019827]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0019827; GO:0032502; GO:0045944; GO:0046983; GO:0070888; GO:1902037; GO:2000738
GN000580	GN000580.1	Q13797	29.6	432	465	1035	1.94e-45	173	ITA9_HUMAN	Integrin alpha-9 (Integrin alpha-RLC)	Homo sapiens (Human)	cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of vasoconstriction [GO:0045906]	integrin binding involved in cell-matrix adhesion [GO:0098640]; signaling receptor activity [GO:0038023]	basal plasma membrane [GO:0009925]; cell surface [GO:0009986]; integrin alpha9-beta1 complex [GO:0034679]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]	GO:0005886; GO:0007155; GO:0007160; GO:0007229; GO:0008305; GO:0009925; GO:0009986; GO:0034679; GO:0038023; GO:0045906; GO:0098609; GO:0098640
GN000587	GN000587.1	Q8BMN3	27.7	311	402	464	3.89e-32	129	ACHB3_MOUSE	Neuronal acetylcholine receptor subunit beta-3	Mus musculus (Mouse)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; heterocyclic compound binding [GO:1901363]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; cation channel complex [GO:0034703]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; neurotransmitter receptor complex [GO:0098878]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0022848; GO:0030594; GO:0032991; GO:0034220; GO:0034703; GO:0035094; GO:0042166; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0098793; GO:0098878; GO:0099171; GO:1901363
GN000588	GN000588.1	Q5IS76	31.6	269	396	494	7.38e-33	132	ACHA6_PANTR	Neuronal acetylcholine receptor subunit alpha-6	Pan troglodytes (Chimpanzee)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0014059; GO:0015464; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN000590	GN000590.1	Q15825	36.5	156	316	494	9.89e-22	98.6	ACHA6_HUMAN	Neuronal acetylcholine receptor subunit alpha-6	Homo sapiens (Human)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; chemical synaptic transmission [GO:0007268]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to acetylcholine [GO:1905144]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007268; GO:0007271; GO:0007274; GO:0014059; GO:0015464; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0099171; GO:1905144
GN000591	GN000591.1	P54245	31.3	278	380	635	1.58e-34	137	LGC4_CAEEL	Ligand-gated ion channel 4	Caenorhabditis elegans	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:1902495
GN000592	GN000592.1	P04755	28.6	336	397	521	2.34e-31	128	ACH3_DROME	Acetylcholine receptor subunit beta-like 1 (Nicotinic acetylcholine receptor beta 1)	Drosophila melanogaster (Fruit fly)	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211
GN000593	GN000593.1	P49882	37.6	433	467	536	1.73e-76	251	ECR_CHITE	Ecdysone receptor (20-hydroxy-ecdysone receptor) (20E receptor) (EcRH) (Ecdysteroid receptor) (Nuclear receptor subfamily 1 group H member 1)	Chironomus tentans (Midge) (Camptochironomus tentans)	cell differentiation [GO:0030154]; ecdysone receptor signaling pathway [GO:0035076]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]	ecdysone binding [GO:0035100]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000978; GO:0004879; GO:0008270; GO:0030154; GO:0035076; GO:0035100; GO:0045944; GO:0090575
GN000598	GN000598.1	Q9FT72	27.4	310	372	713	1.06e-23	106	RQL3_ARATH	ATP-dependent DNA helicase Q-like 3 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ3) (RecQ-like protein 3) (AtRecQ3) (AtRecQl3)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004386; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006310; GO:0009378; GO:0016887; GO:0043138; GO:1990814
GN000599	GN000599.1	Q20561	52.7	93	165	147	1.04e-20	85.9	HLH13_CAEEL	Helix-loop-helix protein 13 (Fer3-like protein) (Nephew of atonal 3)	Caenorhabditis elegans	dauer exit [GO:0043054]; developmental process [GO:0032502]; regulation of transcription by RNA polymerase II [GO:0006357]; response to oxidative stress [GO:0006979]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634; GO:0005737; GO:0006357; GO:0006979; GO:0032502; GO:0043054; GO:0046983; GO:0140297
GN000604	GN000604.1	Q9FT72	25.1	491	497	713	8.35e-29	124	RQL3_ARATH	ATP-dependent DNA helicase Q-like 3 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ3) (RecQ-like protein 3) (AtRecQ3) (AtRecQl3)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004386; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006310; GO:0009378; GO:0016887; GO:0043138; GO:1990814
GN000605	GN000605.1	Q20561	53.3	90	166	147	1.19e-19	83.2	HLH13_CAEEL	Helix-loop-helix protein 13 (Fer3-like protein) (Nephew of atonal 3)	Caenorhabditis elegans	dauer exit [GO:0043054]; developmental process [GO:0032502]; regulation of transcription by RNA polymerase II [GO:0006357]; response to oxidative stress [GO:0006979]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634; GO:0005737; GO:0006357; GO:0006979; GO:0032502; GO:0043054; GO:0046983; GO:0140297
GN000606	GN000606.1	O42646	31.9	135	648	227	1.27e-09	62.4	UBC6_SCHPO	Ubiquitin-conjugating enzyme E2 6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 6) (Ubiquitin carrier protein 6) (Ubiquitin-protein ligase 6)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	ERAD pathway [GO:0036503]; inner nuclear membrane-associated protein degradation pathway [GO:0180027]; protein polyubiquitination [GO:0000209]	ubiquitin conjugating enzyme activity [GO:0061631]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0000209; GO:0005783; GO:0005789; GO:0036503; GO:0061631; GO:0180027
GN000607	GN000607.1	B5X3C1	53.9	648	672	666	5.79e-239	680	GALC_SALSA	Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactosylceramidase)	Salmo salar (Atlantic salmon)	galactosylceramide catabolic process [GO:0006683]	galactosylceramidase activity [GO:0004336]	lysosome [GO:0005764]	GO:0004336; GO:0005764; GO:0006683
GN000608	GN000608.1	E1B836	53.2	252	257	259	1.74e-80	245	ENKUR_BOVIN	Enkurin	Bos taurus (Bovine)	establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]	calmodulin binding [GO:0005516]	9+0 motile cilium [GO:0097728]; acrosomal vesicle [GO:0001669]; axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0001669; GO:0005516; GO:0005879; GO:0030317; GO:0036126; GO:0061966; GO:0097225; GO:0097228; GO:0097728; GO:0160112
GN000609	GN000609.1	Q3U1J1	42.9	63	257	259	1.19e-10	63.5	TFPT_MOUSE	TCF3 fusion partner homolog (Protein FB1) (Protein amida)	Mus musculus (Mouse)	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; chromatin remodeling [GO:0006338]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA repair [GO:0006282]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of embryonic development [GO:0045995]; telomere maintenance [GO:0000723]	DNA binding [GO:0003677]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; Ino80 complex [GO:0031011]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000723; GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0005884; GO:0006275; GO:0006282; GO:0006338; GO:0006915; GO:0019901; GO:0031011; GO:0033044; GO:0043065; GO:0044877; GO:0045739; GO:0045893; GO:0045995; GO:0051726; GO:0060382; GO:0097190; GO:1904507
GN000610	GN000610.1	Q8NEG5	38.1	299	722	633	6.34e-64	227	ZSWM2_HUMAN	E3 ubiquitin-protein ligase ZSWIM2 (EC 2.3.2.27) (MEKK1-related protein X) (MEX) (RING-type E3 ubiquitin transferase ZSWIM2) (ZZ-type zinc finger-containing protein 2) (Zinc finger SWIM domain-containing protein 2)	Homo sapiens (Human)	protein polyubiquitination [GO:0000209]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]		GO:0000209; GO:0008270; GO:0061630
GN000611	GN000611.1	Q6QLW4	81.7	109	115	109	4.59e-65	195	CYC_PECGU	Cytochrome c	Pectinaria gouldii (Trumpet worm) (Ice-cream cone worm)		electron transfer activity [GO:0009055]; heme binding [GO:0020037]	mitochondrial intermembrane space [GO:0005758]	GO:0005758; GO:0009055; GO:0020037
GN000612	GN000612.1	Q02399	84.0	288	307	292	2.28e-184	512	CDK5_BOVIN	Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Proline-directed protein kinase 33 kDa subunit) (PDPK) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)	Bos taurus (Bovine)	axonogenesis [GO:0007409]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of cell cycle phase transition [GO:1901987]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of synaptic plasticity [GO:0048167]; synaptic vesicle transport [GO:0048489]	acetylcholine receptor activator activity [GO:0030549]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; ErbB-2 class receptor binding [GO:0005176]; ErbB-3 class receptor binding [GO:0043125]; histone kinase activity [GO:0035173]; kinase activity [GO:0016301]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]	axon [GO:0030424]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	GO:0000307; GO:0004674; GO:0004693; GO:0005176; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0007160; GO:0007409; GO:0014069; GO:0016020; GO:0016301; GO:0016477; GO:0030027; GO:0030175; GO:0030182; GO:0030334; GO:0030424; GO:0030425; GO:0030426; GO:0030549; GO:0031175; GO:0031594; GO:0035173; GO:0043025; GO:0043125; GO:0043204; GO:0043525; GO:0045202; GO:0048167; GO:0048489; GO:0050321; GO:0051402; GO:0061001; GO:0106310; GO:1901987
GN000613	GN000613.1	Q7ZV90	36.8	133	239	639	3.39e-12	68.9	PIF1_DANRE	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0000723; GO:0005524; GO:0005634; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0043139
GN000614	GN000614.1	P08770	30.2	159	156	807	1.16e-12	67.8	TRA1_MAIZE	Putative AC transposase (ORFA)	Zea mays (Maize)		DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]		GO:0003677; GO:0046983
GN000620	GN000620.1	P02552	98.4	451	451	451	0.0	910	TBA1A_CHICK	Tubulin alpha-1A chain (EC 3.6.5.-) [Cleaved into: Detyrosinated tubulin alpha-1A chain]	Gallus gallus (Chicken)	microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; neuron differentiation [GO:0030182]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]	microtubule [GO:0005874]	GO:0000278; GO:0003924; GO:0005200; GO:0005525; GO:0005874; GO:0007017; GO:0030182
GN000621	GN000621.1	P53708	28.0	350	344	1063	5.62e-15	79.7	ITA8_HUMAN	Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]	Homo sapiens (Human)	cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; establishment of protein localization [GO:0045184]; integrin-mediated signaling pathway [GO:0007229]; kidney development [GO:0001822]; mesodermal cell differentiation [GO:0048333]; positive regulation of transcription by RNA polymerase II [GO:0045944]; smooth muscle cell differentiation [GO:0051145]; smooth muscle tissue development [GO:0048745]; substrate adhesion-dependent cell spreading [GO:0034446]	signaling receptor activity [GO:0038023]	apical part of cell [GO:0045177]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; integrin alpha8-beta1 complex [GO:0034678]; integrin complex [GO:0008305]; plasma membrane [GO:0005886]	GO:0001822; GO:0005783; GO:0005886; GO:0005925; GO:0007160; GO:0007229; GO:0008305; GO:0009986; GO:0034446; GO:0034678; GO:0038023; GO:0045177; GO:0045184; GO:0045944; GO:0048333; GO:0048745; GO:0051145; GO:0098609
GN000623	GN000623.1	P22770	28.6	360	423	502	1.07e-33	135	ACHA7_CHICK	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005737; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030424; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043204; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN000624	GN000624.1	P22770	28.5	326	384	502	1.88e-30	125	ACHA7_CHICK	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005737; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030424; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043204; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN000625	GN000625.1	P22770	29.1	326	384	502	3.11e-32	130	ACHA7_CHICK	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005737; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030424; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043204; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN000626	GN000626.1	P22770	28.9	332	391	502	1.00e-32	131	ACHA7_CHICK	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005737; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030424; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043204; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN000627	GN000627.1	P22770	32.1	262	255	502	6.49e-32	125	ACHA7_CHICK	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005737; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030424; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043204; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN000632	GN000632.1	Q9UBI1	39.7	194	195	195	2.46e-41	141	COMD3_HUMAN	COMM domain-containing protein 3 (Protein Bup) (Protein PIL)	Homo sapiens (Human)	endocytic recycling [GO:0032456]; sodium ion transport [GO:0006814]		cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0005576; GO:0005634; GO:0005737; GO:0005789; GO:0006814; GO:0010008; GO:0032456; GO:0032991; GO:1904813
GN000634	GN000634.1	F1QJX5	40.5	1898	1806	1863	0.0	1333	UBR3_DANRE	E3 ubiquitin-protein ligase ubr3 (EC 2.3.2.27) (E3 ubiquitin-protein transferase ubr3)	Danio rerio (Zebrafish) (Brachydanio rerio)	eye morphogenesis [GO:0048592]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005737; GO:0008270; GO:0016567; GO:0048592; GO:0061630; GO:0071596
GN000638	GN000638.1	O70497	49.0	202	355	314	6.25e-62	203	FCN2_MOUSE	Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin)	Mus musculus (Mouse)	cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; host-mediated suppression of symbiont invasion [GO:0046597]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of opsonization [GO:1903028]; protein localization to cell surface [GO:0034394]; proteolysis [GO:0006508]; recognition of apoptotic cell [GO:0043654]	antigen binding [GO:0003823]; calcium-dependent protein binding [GO:0048306]; carbohydrate derivative binding [GO:0097367]; G protein-coupled receptor binding [GO:0001664]; identical protein binding [GO:0042802]; lipoteichoic acid immune receptor activity [GO:0070892]; mannan binding [GO:2001065]; pattern recognition receptor activity [GO:0038187]; proteoglycan binding [GO:0043394]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; serine-type endopeptidase complex [GO:1905370]; symbiont cell surface [GO:0106139]	GO:0001664; GO:0001867; GO:0002752; GO:0003823; GO:0005102; GO:0005576; GO:0005886; GO:0006508; GO:0007186; GO:0009986; GO:0031012; GO:0032757; GO:0033691; GO:0034394; GO:0038187; GO:0042802; GO:0043394; GO:0043654; GO:0046597; GO:0048306; GO:0070892; GO:0097367; GO:0106139; GO:1903028; GO:1905370; GO:2001065
GN000639	GN000639.1	Q9C6W5	44.6	240	491	648	1.60e-60	213	AB14G_ARATH	ABC transporter G family member 14 (ABC transporter ABCG.14) (AtABCG14) (Protein INSENSITIVE TO TEMPERATURE 211) (White-brown complex homolog protein 14) (AtWBC14)	Arabidopsis thaliana (Mouse-ear cress)	cotyledon vascular tissue pattern formation [GO:0010588]; cytokinin transport [GO:0010184]; cytokinin-activated signaling pathway [GO:0009736]; defense response to bacterium [GO:0042742]; export across plasma membrane [GO:0140115]; export from cell [GO:0140352]; response to hydrogen peroxide [GO:0042542]; stem vascular tissue pattern formation [GO:0010222]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cytokinin binding [GO:0044373]; efflux transmembrane transporter activity [GO:0015562]	plasma membrane [GO:0005886]	GO:0005524; GO:0005886; GO:0009736; GO:0010184; GO:0010222; GO:0010588; GO:0015562; GO:0016887; GO:0042542; GO:0042626; GO:0042742; GO:0044373; GO:0140115; GO:0140352; GO:0140359
GN000646	GN000646.1	P15043	35.7	84	114	609	6.06e-09	55.5	RECQ_ECOLI	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Escherichia coli (strain K12)	DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; G-quadruplex unwinding activity [GO:0160225]; single-stranded DNA helicase activity [GO:0017116]; transition metal ion binding [GO:0046914]; zinc ion binding [GO:0008270]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]; single-stranded DNA-dependent ATP-dependent DNA helicase complex [GO:0017117]	GO:0003677; GO:0003678; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0006974; GO:0008094; GO:0008270; GO:0009432; GO:0016887; GO:0017116; GO:0017117; GO:0030894; GO:0043138; GO:0043590; GO:0046914; GO:0160225
GN000651	GN000651.1	A8KBL5	48.3	420	488	448	5.10e-129	385	S38AB_DANRE	Putative sodium-coupled neutral amino acid transporter 11 (Solute carrier family 38 member 11)	Danio rerio (Zebrafish) (Brachydanio rerio)	amino acid transmembrane transport [GO:0003333]	L-amino acid transmembrane transporter activity [GO:0015179]	membrane [GO:0016020]	GO:0003333; GO:0015179; GO:0016020
GN000655	GN000655.1	Q8TEB9	28.8	219	233	315	2.82e-19	87.8	RHBL4_HUMAN	Rhomboid-related protein 4 (RRP4) (EC 3.4.21.105) (Rhomboid domain-containing protein 1) (Rhomboid-like protein 4)	Homo sapiens (Human)	cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; ERAD pathway [GO:0036503]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein processing [GO:0010954]; positive regulation of secretion [GO:0051047]; post-translational protein modification [GO:0043687]; retrograde protein transport, ER to cytosol [GO:0030970]; spermatid differentiation [GO:0048515]	endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; mitochondrial membrane [GO:0031966]	GO:0004175; GO:0004252; GO:0005783; GO:0005789; GO:0010954; GO:0030970; GO:0031293; GO:0031966; GO:0033619; GO:0034620; GO:0034644; GO:0036503; GO:0043066; GO:0043687; GO:0044322; GO:0045732; GO:0048515; GO:0051047
GN000659	GN000659.1	H2A0M7	42.0	338	394	793	1.21e-59	209	PLSP_PINMG	Peroxidase-like protein	Margaritifera margaritifera (Freshwater pearl mussel)	response to oxidative stress [GO:0006979]	heme binding [GO:0020037]; peroxidase activity [GO:0004601]	extracellular region [GO:0005576]	GO:0004601; GO:0005576; GO:0006979; GO:0020037
GN000666	GN000666.1	Q921L8	53.4	521	615	608	5.40e-192	556	GLT11_MOUSE	Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11)	Mus musculus (Mouse)	cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; Notch receptor processing [GO:0007220]; Notch signaling involved in heart development [GO:0061314]; protein O-linked glycosylation [GO:0006493]; regulation of Notch signaling pathway [GO:0008593]	Notch binding [GO:0005112]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0004653; GO:0005112; GO:0005794; GO:0006493; GO:0007220; GO:0007368; GO:0008593; GO:0060271; GO:0061314
GN000667	GN000667.1	Q9VJY9	38.3	290	267	465	1.62e-41	151	LOQS_DROME	Protein Loquacious	Drosophila melanogaster (Fruit fly)	central nervous system development [GO:0007417]; dosage compensation by hyperactivation of X chromosome [GO:0009047]; female germ-line stem cell asymmetric division [GO:0048132]; germ-line stem cell population maintenance [GO:0030718]; miRNA metabolic process [GO:0010586]; pre-miRNA processing [GO:0031054]; regulation of regulatory ncRNA processing [GO:0070920]; RISC complex assembly [GO:0070922]; siRNA processing [GO:0030422]	double-stranded RNA binding [GO:0003725]; RISC complex binding [GO:1905172]; siRNA binding [GO:0035197]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]	GO:0003725; GO:0005634; GO:0005737; GO:0005829; GO:0007417; GO:0009047; GO:0010586; GO:0016442; GO:0030422; GO:0030718; GO:0031054; GO:0035197; GO:0048132; GO:0070578; GO:0070920; GO:0070922; GO:1905172
GN000668	GN000668.1	Q95ZJ1	47.9	511	598	626	3.71e-154	459	GALT5_CAEEL	Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5)	Caenorhabditis elegans	IRE1-mediated unfolded protein response [GO:0036498]; protein O-linked glycosylation [GO:0006493]	polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0004653; GO:0005794; GO:0006493; GO:0036498
GN000671	GN000671.1	Q70E73	37.8	535	1370	1250	9.70e-78	285	RAPH1_HUMAN	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]	protein-macromolecule adaptor activity [GO:0030674]	cytosol [GO:0005829]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]	GO:0005829; GO:0005886; GO:0030027; GO:0030175; GO:0030674; GO:0035556
GN000673	GN000673.1	Q66I06	53.5	101	212	191	3.49e-26	102	GGACB_DANRE	Gamma-glutamylaminecyclotransferase B (GGACT B) (EC 4.3.2.8) (AIG2-like domain-containing protein 1-B) (Gamma-glutamylamine cyclotransferase B) (Gamma-glutamylamine cyclotransferase, tandem duplicate 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	modified amino acid catabolic process [GO:0042219]	gamma-glutamylaminecyclotransferase activity [GO:0061929]	cytosol [GO:0005829]	GO:0005829; GO:0042219; GO:0061929
GN000674	GN000674.1	P11233	83.0	176	218	206	9.54e-99	288	RALA_HUMAN	Ras-related protein Ral-A (EC 3.6.5.2)	Homo sapiens (Human)	chemotaxis [GO:0006935]; membrane raft localization [GO:0051665]; neural tube closure [GO:0001843]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of mitochondrial fission [GO:0090141]; protein localization to mitochondrion [GO:0070585]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of exocytosis [GO:0017157]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; signal transduction [GO:0007165]	ATPase binding [GO:0051117]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin binding [GO:0017022]; ubiquitin protein ligase binding [GO:0031625]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]	GO:0001843; GO:0003924; GO:0003925; GO:0005525; GO:0005739; GO:0005886; GO:0005925; GO:0006935; GO:0007165; GO:0007265; GO:0009986; GO:0017022; GO:0017157; GO:0019003; GO:0030659; GO:0031623; GO:0031625; GO:0031755; GO:0032154; GO:0032956; GO:0045742; GO:0051117; GO:0051491; GO:0051665; GO:0070062; GO:0070585; GO:0090141; GO:0090543; GO:0097060; GO:0098685; GO:0099149
GN000683	GN000683.1	O75533	75.3	1358	1339	1304	0.0	1805	SF3B1_HUMAN	Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [GO:0000388]; U2-type prespliceosome assembly [GO:1903241]	mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; splicing factor binding [GO:1990935]	B-WICH complex [GO:0110016]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U11/U12 snRNP [GO:0034693]; U12-type catalytic step 2 spliceosome [GO:0071018]; U12-type precatalytic spliceosome [GO:0071016]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]	GO:0000245; GO:0000375; GO:0000387; GO:0000388; GO:0000398; GO:0003723; GO:0003729; GO:0005634; GO:0005654; GO:0005681; GO:0005684; GO:0005686; GO:0005689; GO:0005730; GO:0006338; GO:0008380; GO:0016607; GO:0034693; GO:0036002; GO:0045292; GO:0045943; GO:0045944; GO:0045945; GO:0071004; GO:0071005; GO:0071006; GO:0071011; GO:0071013; GO:0071016; GO:0071018; GO:0110016; GO:1903241; GO:1990935
GN000684	GN000684.1	Q9H8M1	62.0	137	149	238	2.21e-62	194	CQ10B_HUMAN	Coenzyme Q-binding protein COQ10 homolog B, mitochondrial	Homo sapiens (Human)	cellular respiration [GO:0045333]	ubiquinone binding [GO:0048039]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0045333; GO:0048039
GN000685	GN000685.1	O42254	34.3	609	622	576	1.52e-95	307	IF2B1_CHICK	Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zip-code binding polypeptide) (Zipcode-binding protein 1) (ZBP-1)	Gallus gallus (Chicken)	CRD-mediated mRNA stabilization [GO:0070934]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; positive regulation of neuron projection development [GO:0010976]	mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]	CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]	GO:0000932; GO:0003729; GO:0003730; GO:0005634; GO:0005829; GO:0007399; GO:0010494; GO:0010976; GO:0017148; GO:0030027; GO:0030175; GO:0030426; GO:0048471; GO:0070934; GO:0070937; GO:1990247
GN000698	GN000698.1	P21265	76.8	448	464	485	2.21e-251	696	PUR8_CHICK	Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase)	Gallus gallus (Chicken)	'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; AMP salvage [GO:0044209]; GMP biosynthetic process [GO:0006177]	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity [GO:0070626]; identical protein binding [GO:0042802]; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [GO:0004018]	cytosol [GO:0005829]; protein-containing complex [GO:0032991]	GO:0004018; GO:0005829; GO:0006177; GO:0006189; GO:0032991; GO:0042802; GO:0044208; GO:0044209; GO:0070626; GO:0097294
GN000703	GN000703.1	A0A1P8AWH8	29.7	528	532	945	1.59e-60	218	XYN1_ARATH	Endo-1,4-beta-xylanase 1 (AtXyn1) (Xylan endohydrolase 1) (Xylanase 1) (EC 3.2.1.8)	Arabidopsis thaliana (Mouse-ear cress)	xylan catabolic process [GO:0045493]	endo-1,4-beta-xylanase activity [GO:0031176]	extracellular region [GO:0005576]; plant-type cell wall [GO:0009505]	GO:0005576; GO:0009505; GO:0031176; GO:0045493
GN000708	GN000708.1	Q96H20	61.3	243	246	258	2.51e-106	310	SNF8_HUMAN	Vacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22)	Homo sapiens (Human)	early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of protein catabolic process [GO:0042176]; regulation of protein complex stability [GO:0061635]; regulation of transcription by RNA polymerase II [GO:0006357]	channel regulator activity [GO:0016247]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; transcription regulator complex [GO:0005667]	GO:0000814; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005829; GO:0005886; GO:0006357; GO:0008289; GO:0010008; GO:0010628; GO:0016020; GO:0016236; GO:0016247; GO:0031902; GO:0032456; GO:0036258; GO:0042176; GO:0042803; GO:0043328; GO:0045022; GO:0045732; GO:0048471; GO:0055037; GO:0061635; GO:0070062; GO:0071985; GO:0090148; GO:1903543
GN000713	GN000713.1	Q6P642	48.2	280	284	242	2.80e-61	197	DNJB6_XENTR	DnaJ homolog subfamily B member 6	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		Hsp70 protein binding [GO:0030544]	nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0005634; GO:0030544; GO:0048471
GN000718	GN000718.1	A9JTX2	44.2	292	290	311	8.26e-79	244	MTG1_XENTR	Mitochondrial ribosome-associated GTPase 1 (Mitochondrial GTPase 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mitochondrial large ribosomal subunit assembly [GO:1902775]; regulation of mitochondrial translation [GO:0070129]	GTP binding [GO:0005525]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial ribosome [GO:0005761]	GO:0005525; GO:0005743; GO:0005759; GO:0005761; GO:0070129; GO:1902775
GN000720	GN000720.1	Q03601	29.6	348	1011	974	4.90e-37	154	NHL1_CAEEL	RING finger protein nhl-1	Caenorhabditis elegans	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]		GO:0000209; GO:0004842; GO:0016567; GO:0043161; GO:0046872; GO:0061630
GN000721	GN000721.1	Q5BIM1	27.7	375	443	580	1.12e-19	95.1	TRI45_BOVIN	E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99) (Tripartite motif-containing protein 45)	Bos taurus (Bovine)		ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0061630
GN000723	GN000723.1	A2A559	48.3	230	260	320	3.16e-75	234	PGAP3_MOUSE	GPI-specific phospholipase A2-like PGAP3 (EC 3.1.1.-) (PER1-like domain-containing protein 1) (Post-GPI attachment to proteins factor 3)	Mus musculus (Mouse)	GPI anchor biosynthetic process [GO:0006506]; GPI anchor metabolic process [GO:0006505]; GPI anchor remodelling [GO:0120574]; GPI anchored protein biosynthesis [GO:0180046]	hydrolase activity, acting on ester bonds [GO:0016788]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005789; GO:0006505; GO:0006506; GO:0016788; GO:0031410; GO:0120574; GO:0180046
GN000724	GN000724.1	Q0VFZ6	33.6	530	562	552	1.42e-58	207	CF210_HUMAN	Cilia- and flagella- associated protein 210 (Coiled-coil domain-containing protein 173)	Homo sapiens (Human)	flagellated sperm motility [GO:0030317]		axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; sperm flagellum [GO:0036126]	GO:0005879; GO:0005930; GO:0030317; GO:0036126; GO:0160112
GN000725	GN000725.1	Q2KI06	41.4	244	255	241	3.63e-62	198	PHOP2_BOVIN	Pyridoxal phosphate phosphatase PHOSPHO2 (EC 3.1.3.74)	Bos taurus (Bovine)		pyridoxal phosphatase activity [GO:0033883]		GO:0033883
GN000726	GN000726.1	Q5E980	26.4	273	269	462	1.25e-33	130	CP20A_BOVIN	Cytochrome P450 20A1 (EC 1.14.-.-)	Bos taurus (Bovine)		heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	membrane [GO:0016020]	GO:0004497; GO:0005506; GO:0016020; GO:0016705; GO:0020037
GN000727	GN000727.1	Q6UW02	41.7	84	94	462	5.35e-14	68.9	CP20A_HUMAN	Cytochrome P450 20A1 (EC 1.14.-.-)	Homo sapiens (Human)		heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	membrane [GO:0016020]	GO:0004497; GO:0005506; GO:0016020; GO:0016705; GO:0020037
GN000731	GN000731.1	O19015	50.6	573	578	669	1.41e-197	571	BGAL_FELCA	Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase)	Felis catus (Cat) (Felis silvestris catus)	galactose catabolic process [GO:0019388]; ganglioside catabolic process [GO:0006689]; keratan sulfate proteoglycan catabolic process [GO:0042340]	beta-galactosidase activity [GO:0004565]	extracellular region [GO:0005576]; lysosome [GO:0005764]; vacuole [GO:0005773]	GO:0004565; GO:0005576; GO:0005764; GO:0005773; GO:0006689; GO:0019388; GO:0042340
GN000733	GN000733.1	Q95ZJ1	59.3	378	378	626	6.67e-164	476	GALT5_CAEEL	Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5)	Caenorhabditis elegans	IRE1-mediated unfolded protein response [GO:0036498]; protein O-linked glycosylation [GO:0006493]	polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0004653; GO:0005794; GO:0006493; GO:0036498
GN000734	GN000734.1	Q5U504	25.4	613	616	614	2.14e-64	226	KLH40_XENLA	Kelch-like protein 40 (Kelch repeat and BTB domain-containing protein 5)	Xenopus laevis (African clawed frog)	negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; skeletal muscle fiber development [GO:0048741]; skeletal muscle fiber differentiation [GO:0098528]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	A band [GO:0031672]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; I band [GO:0031674]	GO:0005737; GO:0031397; GO:0031398; GO:0031463; GO:0031672; GO:0031674; GO:0032435; GO:0032436; GO:0043161; GO:0048741; GO:0098528; GO:1990756
GN000735	GN000735.1	Q6UW02	41.7	84	94	462	7.32e-14	68.6	CP20A_HUMAN	Cytochrome P450 20A1 (EC 1.14.-.-)	Homo sapiens (Human)		heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	membrane [GO:0016020]	GO:0004497; GO:0005506; GO:0016020; GO:0016705; GO:0020037
GN000736	GN000736.1	Q07816	35.8	193	155	229	4.02e-33	119	B2CL1_CHICK	Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)	Gallus gallus (Chicken)	defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of apoptotic process [GO:0043065]; regulation of cytokinesis [GO:0032465]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; release of cytochrome c from mitochondria [GO:0001836]	BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]	Bcl-2 family protein complex [GO:0097136]; centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; nuclear membrane [GO:0031965]; synaptic vesicle membrane [GO:0030672]	GO:0001836; GO:0005741; GO:0005759; GO:0005783; GO:0005813; GO:0005829; GO:0008630; GO:0015267; GO:0019901; GO:0030672; GO:0031965; GO:0032465; GO:0042802; GO:0043065; GO:0043066; GO:0046902; GO:0051434; GO:0051607; GO:0051881; GO:0097136; GO:0097192; GO:1900118; GO:1902230; GO:1902236; GO:1903077
GN000737	GN000737.1	Q64373	50.0	104	148	233	5.29e-29	108	B2CL1_MOUSE	Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)	Mus musculus (Mouse)	apoptotic process in bone marrow cell [GO:0071839]; cell population proliferation [GO:0008283]; cellular response to alkaloid [GO:0071312]; cellular response to amino acid stimulus [GO:0071230]; cellular response to gamma radiation [GO:0071480]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fertilization [GO:0009566]; germ cell development [GO:0007281]; hepatocyte apoptotic process [GO:0097284]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; male gonad development [GO:0008584]; mitochondrion organization [GO:0007005]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; neuron apoptotic process [GO:0051402]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic process [GO:0043065]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of synaptic vesicle clustering [GO:2000809]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; regulation of apoptotic process [GO:0042981]; regulation of cytokinesis [GO:0032465]; regulation of growth [GO:0040008]; regulation of long-term synaptic depression [GO:1900452]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of synaptic vesicle endocytosis [GO:1900242]; release of cytochrome c from mitochondria [GO:0001836]; response to cycloheximide [GO:0046898]; response to cytokine [GO:0034097]; response to ischemia [GO:0002931]; response to radiation [GO:0009314]; response to virus [GO:0009615]; spermatogenesis [GO:0007283]; synaptic vesicle recycling via endosome [GO:0036466]	BH domain binding [GO:0051400]; BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; clathrin binding [GO:0030276]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]	Bcl-2 family protein complex [GO:0097136]; centrosome [GO:0005813]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; presynapse [GO:0098793]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	GO:0001541; GO:0001701; GO:0001836; GO:0002931; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005783; GO:0005813; GO:0005829; GO:0005905; GO:0007005; GO:0007281; GO:0007283; GO:0008021; GO:0008283; GO:0008284; GO:0008584; GO:0008630; GO:0009314; GO:0009566; GO:0009615; GO:0015267; GO:0016020; GO:0019901; GO:0030276; GO:0030672; GO:0031965; GO:0031966; GO:0032465; GO:0034097; GO:0036466; GO:0040008; GO:0042802; GO:0042981; GO:0043027; GO:0043065; GO:0043066; GO:0043524; GO:0044877; GO:0046898; GO:0046902; GO:0051020; GO:0051400; GO:0051402; GO:0051434; GO:0051607; GO:0051881; GO:0071230; GO:0071312; GO:0071480; GO:0071839; GO:0090201; GO:0097136; GO:0097192; GO:0097284; GO:0097371; GO:0098793; GO:1900118; GO:1900242; GO:1900244; GO:1900452; GO:1901029; GO:1902042; GO:1902230; GO:1902236; GO:1903077; GO:2000302; GO:2000809; GO:2000811; GO:2001171; GO:2001243
GN000743	GN000743.1	P77735	32.1	305	338	324	4.43e-44	157	YAJO_ECOLI	1-deoxyxylulose-5-phosphate synthase YajO (EC 1.1.-.-)	Escherichia coli (strain K12)	isoprenoid biosynthetic process via mevalonate [GO:1902767]; thiamine metabolic process [GO:0006772]	oxidoreductase activity [GO:0016491]	cytosol [GO:0005829]	GO:0005829; GO:0006772; GO:0016491; GO:1902767
GN000744	GN000744.1	P86856	34.2	325	321	321	2.99e-42	151	MANL_MYTCA	Nacrein-like protein	Mytilus californianus (California mussel)	one-carbon metabolic process [GO:0006730]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0004089; GO:0005576; GO:0006730; GO:0008270
GN000748	GN000748.1	Q9TUI8	42.5	546	570	579	3.24e-132	400	FAAH1_PIG	Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidase) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1)	Sus scrofa (Pig)	fatty acid catabolic process [GO:0009062]; monoacylglycerol catabolic process [GO:0052651]	amidase activity [GO:0004040]; carboxylesterase activity [GO:0106435]; fatty acid amide hydrolase activity [GO:0017064]; monoacylglycerol lipase activity [GO:0047372]; N-(long-chain-acyl)ethanolamine deacylase activity [GO:0047412]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; organelle membrane [GO:0031090]	GO:0000139; GO:0004040; GO:0005789; GO:0009062; GO:0017064; GO:0031090; GO:0047372; GO:0047412; GO:0052651; GO:0106435
GN000753	GN000753.1	Q498E7	49.2	620	902	960	7.46e-186	563	SMAL1_XENLA	SNF2 related chromatin remodeling annealing helicase 1 (EC 3.6.4.-) (EC 5.6.2.-) (HepA-related protein) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1) (Sucrose nonfermenting protein 2-like 1)	Xenopus laevis (African clawed frog)	DNA repair [GO:0006281]; regulation of transcription by RNA polymerase II [GO:0006357]; replication fork processing [GO:0031297]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA/DNA annealing activity [GO:0036310]	nuclear replication fork [GO:0043596]; nucleus [GO:0005634]	GO:0005524; GO:0005634; GO:0006281; GO:0006357; GO:0016887; GO:0031297; GO:0036310; GO:0043596
GN000756	GN000756.1	B2RUY7	40.6	106	142	222	1.05e-19	84.3	VWC2L_HUMAN	von Willebrand factor C domain-containing protein 2-like (VWC2-like protein) (Brorin-like)	Homo sapiens (Human)	negative regulation of BMP signaling pathway [GO:0030514]		AMPA glutamate receptor complex [GO:0032281]; extracellular region [GO:0005576]; synapse [GO:0045202]	GO:0005576; GO:0030514; GO:0032281; GO:0045202
GN000758	GN000758.1	P16332	75.4	711	742	748	0.0	1090	MUTA_MOUSE	Methylmalonyl-CoA mutase, mitochondrial (MCM) (EC 5.4.99.2) (Methylmalonyl-CoA isomerase)	Mus musculus (Mouse)	homocysteine metabolic process [GO:0050667]; positive regulation of GTPase activity [GO:0043547]; post-embryonic development [GO:0009791]; succinyl-CoA biosynthetic process [GO:1901290]	cobalamin binding [GO:0031419]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methylmalonyl-CoA mutase activity [GO:0004494]; modified amino acid binding [GO:0072341]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003924; GO:0004494; GO:0005737; GO:0005739; GO:0005759; GO:0009791; GO:0031419; GO:0042802; GO:0042803; GO:0043547; GO:0046872; GO:0050667; GO:0072341; GO:1901290
GN000759	GN000759.1	Q8AXU4	38.0	342	518	465	1.61e-66	225	CALRL_ONCGO	Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)	Oncorhynchus gorbuscha (Pink salmon) (Salmo gorbuscha)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]	adrenomedullin receptor activity [GO:0001605]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948]	plasma membrane [GO:0005886]	GO:0001525; GO:0001605; GO:0001635; GO:0004948; GO:0005886; GO:0007166; GO:0007189
GN000764	GN000764.1	Q5UPX0	33.3	129	179	548	3.23e-17	81.6	YR290_MIMIV	Putative ATP-dependent RNA helicase R290 (EC 3.6.4.13)	Acanthamoeba polyphaga mimivirus (APMV)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]		GO:0003676; GO:0003724; GO:0005524; GO:0006260; GO:0006281; GO:0006310; GO:0016887; GO:0043138
GN000765	GN000765.1	O93530	35.4	164	175	1436	1.09e-22	97.4	WRN_XENLA	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Focus-forming activity 1) (FFA-1) (Werner syndrome protein homolog) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Xenopus laevis (African clawed frog)	DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; four-way junction helicase activity [GO:0009378]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000723; GO:0000724; GO:0000781; GO:0003676; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006259; GO:0006260; GO:0008408; GO:0009378; GO:0016887; GO:0030145; GO:0032392; GO:0043138
GN000767	GN000767.1	Q6P6S0	27.3	440	433	419	8.40e-36	139	SNP47_RAT	Synaptosomal-associated protein 47 (SNAP-47) (Synaptosomal-associated 47 kDa protein)	Rattus norvegicus (Rat)	exocytic insertion of neurotransmitter receptor to postsynaptic membrane [GO:0098967]; exocytosis [GO:0006887]; long-term synaptic potentiation [GO:0060291]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]	SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]	BLOC-1 complex [GO:0031083]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynaptic active zone [GO:0048786]; SNARE complex [GO:0031201]	GO:0005484; GO:0006887; GO:0012505; GO:0014069; GO:0016020; GO:0016082; GO:0019905; GO:0030425; GO:0031083; GO:0031201; GO:0031629; GO:0043025; GO:0048471; GO:0048786; GO:0060291; GO:0098686; GO:0098967; GO:0098978
GN000768	GN000768.1	P21775	62.9	428	428	434	7.83e-173	493	THIKA_RAT	3-ketoacyl-CoA thiolase A, peroxisomal (EC 2.3.1.16) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Acetyl-CoA acyltransferase A) (EC 2.3.1.9) (Beta-ketothiolase A) (Peroxisomal 3-oxoacyl-CoA thiolase A) (Thiolase A)	Rattus norvegicus (Rat)	bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid biosynthetic process [GO:0006633]; phenylacetate catabolic process [GO:0010124]; response to nutrient [GO:0007584]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]; very long-chain fatty acid metabolic process [GO:0000038]	acetate CoA-transferase activity [GO:0008775]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; long-chain fatty acyl-CoA oxidase activity [GO:0120524]	cytosol [GO:0005829]; peroxisome [GO:0005777]	GO:0000038; GO:0003985; GO:0003988; GO:0005777; GO:0005829; GO:0006633; GO:0006635; GO:0007584; GO:0008206; GO:0008775; GO:0009410; GO:0010124; GO:0033540; GO:0048545; GO:0050633; GO:0120524
GN000769	GN000769.1	Q9ERH8	48.2	448	559	703	7.42e-122	377	S28A3_MOUSE	Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (mCNT3)	Mus musculus (Mouse)	nucleoside transmembrane transport [GO:1901642]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; pyrimidine-containing compound transmembrane transport [GO:0072531]; retina homeostasis [GO:0001895]; uridine transmembrane transport [GO:0015862]	purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213]	brush border membrane [GO:0031526]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0001895; GO:0005789; GO:0005886; GO:0015213; GO:0015389; GO:0015390; GO:0015860; GO:0015862; GO:0015864; GO:0031526; GO:0072531; GO:1901642
GN000775	GN000775.1	E1C2U2	35.2	1104	2613	2326	3.83e-168	581	RIF1_CHICK	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)	Gallus gallus (Chicken)	DNA damage response [GO:0006974]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]		chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; spindle [GO:0005819]	GO:0000781; GO:0005634; GO:0005694; GO:0005819; GO:0006974; GO:0035861; GO:0045830; GO:2000042; GO:2001034
GN000776	GN000776.1	O42222	31.5	365	411	374	2.69e-47	169	GDF8_DANRE	Growth/differentiation factor 8 (GDF-8) (Myostatin) (Myostatin-1) (zfMSTN-1) (Myostatin-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	cardiac muscle myoblast proliferation [GO:0110021]; immune response [GO:0006955]; muscle organ development [GO:0007517]; negative regulation of cardiac muscle myoblast proliferation [GO:0110023]; negative regulation of growth [GO:0045926]; negative regulation of growth rate [GO:0045967]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of striated muscle tissue development [GO:0045843]; regulation of muscle hyperplasia [GO:0014738]; skeletal muscle tissue development [GO:0007519]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular trabecula myocardium morphogenesis [GO:0003222]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0003222; GO:0005102; GO:0005125; GO:0005576; GO:0006955; GO:0007179; GO:0007517; GO:0007519; GO:0008083; GO:0014738; GO:0045843; GO:0045926; GO:0045967; GO:0048642; GO:0110021; GO:0110023
GN000781	GN000781.1	Q13617	51.1	176	236	745	5.99e-48	171	CUL2_HUMAN	Cullin-2 (CUL-2)	Homo sapiens (Human)	G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of beige fat cell differentiation [GO:0160276]; negative regulation of DNA-templated DNA replication [GO:2000104]; negative regulation of transcription by RNA polymerase II [GO:0000122]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0000082; GO:0000122; GO:0004842; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0016567; GO:0019005; GO:0031146; GO:0031462; GO:0031625; GO:0043161; GO:0072344; GO:0097193; GO:0140627; GO:0160072; GO:0160276; GO:1990116; GO:2000104
GN000784	GN000784.1	Q6IQX7	32.9	774	766	774	1.15e-111	360	CHSS2_MOUSE	Chondroitin-polymerizing factor, non-catalytic subunit (ChPF) (Chondroitin sulfate synthase 2)	Mus musculus (Mouse)	chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; glycosyltransferase activity [GO:0016757]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510]; protein-macromolecule adaptor activity [GO:0030674]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0005794; GO:0005829; GO:0016757; GO:0030674; GO:0032580; GO:0047238; GO:0050510; GO:0050650
GN000786	GN000786.1	Q9HAY6	25.0	531	546	547	3.69e-34	139	BCDO1_HUMAN	Beta,beta-carotene 15,15'-dioxygenase (EC 1.13.11.63) (Beta-carotene dioxygenase 1) (Beta-carotene oxygenase 1)	Homo sapiens (Human)	carotene catabolic process [GO:0016121]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; vitamin A biosynthetic process [GO:0035238]	beta-carotene 15,15'-dioxygenase activity [GO:0003834]	cytosol [GO:0005829]	GO:0001523; GO:0003834; GO:0005829; GO:0016121; GO:0035238; GO:0042572; GO:0042574
GN000788	GN000788.1	Q58CU2	67.6	312	992	502	7.78e-143	439	E41L5_BOVIN	Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5)	Bos taurus (Bovine)	actomyosin structure organization [GO:0031032]	cytoskeletal protein binding [GO:0008092]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]	GO:0001917; GO:0005737; GO:0005856; GO:0005886; GO:0005912; GO:0008092; GO:0031032
GN000797	GN000797.1	Q92100	33.4	287	335	521	1.64e-51	181	CP1A1_PLEPL	Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1)	Pleuronectes platessa (European plaice)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	endoplasmic reticulum membrane [GO:0005789]	GO:0004508; GO:0005506; GO:0005789; GO:0020037; GO:0042446; GO:0042448
GN000804	GN000804.1	P23953	32.4	558	570	554	1.79e-72	244	EST1C_MOUSE	Carboxylesterase 1C (EC 3.1.1.1) (Liver carboxylesterase N) (Lung surfactant convertase) (PES-N)	Mus musculus (Mouse)	response to bacterium [GO:0009617]; short-chain fatty acid catabolic process [GO:0019626]	carboxylesterase activity [GO:0106435]; hydrolase activity, acting on ester bonds [GO:0016788]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; protein homodimerization activity [GO:0042803]; retinyl-palmitate esterase activity [GO:0050253]; sterol ester esterase activity [GO:0004771]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]	GO:0004771; GO:0005576; GO:0005737; GO:0005783; GO:0005788; GO:0005811; GO:0009617; GO:0016788; GO:0019626; GO:0042803; GO:0047374; GO:0050253; GO:0106435
GN000805	GN000805.1	Q8BK48	34.0	568	582	559	1.32e-73	248	EST2E_MOUSE	Pyrethroid hydrolase Ces2e (EC 3.1.1.88) (Carboxylic ester hydrolase) (EC 3.1.1.-) (carboxylesterase 2E)	Mus musculus (Mouse)	cocaine catabolic process [GO:0050784]; detoxification [GO:0098754]; morphine catabolic process [GO:0071273]; prostaglandin metabolic process [GO:0006693]	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; carboxylesterase activity [GO:0106435]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; retinyl-palmitate esterase activity [GO:0050253]; trans-permethrin hydrolase activity [GO:0102209]	endoplasmic reticulum [GO:0005783]	GO:0005783; GO:0006693; GO:0047374; GO:0047376; GO:0050253; GO:0050784; GO:0071273; GO:0098754; GO:0102209; GO:0106435
GN000806	GN000806.1	P10959	33.4	566	572	549	2.34e-72	244	EST1C_RAT	Carboxylesterase 1C (EC 3.1.1.1) (Carboxyesterase ES-1) (E1) (ES-THET) (Esterase-2) (Liver carboxylesterase 1) (Neutral retinyl ester hydrolase) (NREH) (Retinyl ester hydrolase) (REH)	Rattus norvegicus (Rat)	short-chain fatty acid catabolic process [GO:0019626]	carboxylesterase activity [GO:0106435]; protein homodimerization activity [GO:0042803]; retinyl-palmitate esterase activity [GO:0050253]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; lipid droplet [GO:0005811]	GO:0005783; GO:0005788; GO:0005811; GO:0019626; GO:0042803; GO:0050253; GO:0106435
GN000807	GN000807.1	P10959	32.7	565	573	549	1.79e-71	242	EST1C_RAT	Carboxylesterase 1C (EC 3.1.1.1) (Carboxyesterase ES-1) (E1) (ES-THET) (Esterase-2) (Liver carboxylesterase 1) (Neutral retinyl ester hydrolase) (NREH) (Retinyl ester hydrolase) (REH)	Rattus norvegicus (Rat)	short-chain fatty acid catabolic process [GO:0019626]	carboxylesterase activity [GO:0106435]; protein homodimerization activity [GO:0042803]; retinyl-palmitate esterase activity [GO:0050253]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; lipid droplet [GO:0005811]	GO:0005783; GO:0005788; GO:0005811; GO:0019626; GO:0042803; GO:0050253; GO:0106435
GN000810	GN000810.1	P91929	32.9	140	183	407	4.10e-15	75.5	NDUAA_DROME	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit)	Drosophila melanogaster (Fruit fly)	mitochondrial electron transport, NADH to ubiquinone [GO:0006120]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271]	GO:0005737; GO:0005739; GO:0005743; GO:0005759; GO:0006120; GO:0008137; GO:0045271
GN000831	GN000831.1	P91778	68.7	508	567	508	1.32e-275	763	AMY_PECMA	Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)	Pecten maximus (King scallop) (Pilgrim's clam)	carbohydrate metabolic process [GO:0005975]	alpha-amylase activity [GO:0004556]; cation binding [GO:0043169]		GO:0004556; GO:0005975; GO:0043169
GN000832	GN000832.1	O54909	39.4	297	316	317	2.04e-62	203	RDH16_MOUSE	Retinol dehydrogenase 16 (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (Cis-retinol androgen dehydrogenase 1)	Mus musculus (Mouse)	9-cis-retinoic acid biosynthetic process [GO:0042904]; androgen biosynthetic process [GO:0006702]; positive regulation of retinoic acid biosynthetic process [GO:1900054]; retinoic acid metabolic process [GO:0042573]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]	11-cis-retinol dehydrogenase (NAD+) activity [GO:0106429]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity [GO:0047044]; androsterone dehydrogenase [NAD(P)+] activity [GO:0047023]; identical protein binding [GO:0042802]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]	GO:0001523; GO:0004745; GO:0005788; GO:0005789; GO:0006702; GO:0008202; GO:0042572; GO:0042573; GO:0042802; GO:0042904; GO:0047023; GO:0047044; GO:0106429; GO:1900054
GN000833	GN000833.1	O81884	43.5	315	358	319	3.89e-86	266	GALDH_ARATH	L-galactose dehydrogenase (At-GalDH) (L-GalDH) (EC 1.1.1.316)	Arabidopsis thaliana (Mouse-ear cress)	L-ascorbic acid biosynthetic process [GO:0019853]	L-galactose dehydrogenase activity [GO:0010349]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0010349; GO:0019853
GN000834	GN000834.1	P13612	27.5	761	1119	1032	7.80e-58	221	ITA4_HUMAN	Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)	Homo sapiens (Human)	axonogenesis involved in innervation [GO:0060385]; B cell differentiation [GO:0030183]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-matrix adhesion involved in ameboidal cell migration [GO:0003366]; cellular response to amyloid-beta [GO:1904646]; cellular response to cytokine stimulus [GO:0071345]; clathrin-dependent extracellular exosome endocytosis [GO:1990771]; diapedesis [GO:0050904]; endodermal cell differentiation [GO:0035987]; heterotypic cell-cell adhesion [GO:0034113]; immune response in gut-associated lymphoid tissue [GO:0002387]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; negative regulation of vasoconstriction [GO:0045906]; neuron projection extension [GO:1990138]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; receptor clustering [GO:0043113]; substrate adhesion-dependent cell spreading [GO:0034446]	cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; protein antigen binding [GO:1990405]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; integrin alpha4-beta1 complex [GO:0034668]; integrin alpha4-beta7 complex [GO:0034669]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	GO:0001968; GO:0002387; GO:0003366; GO:0005178; GO:0005886; GO:0005925; GO:0007159; GO:0007160; GO:0007229; GO:0009986; GO:0015026; GO:0016020; GO:0030183; GO:0030426; GO:0033631; GO:0034113; GO:0034446; GO:0034668; GO:0034669; GO:0035987; GO:0038023; GO:0043025; GO:0043113; GO:0045906; GO:0050839; GO:0050901; GO:0050904; GO:0060385; GO:0070062; GO:0071345; GO:0098609; GO:1903238; GO:1904646; GO:1905564; GO:1990138; GO:1990405; GO:1990771; GO:2000353; GO:2000406
GN000835	GN000835.1	P13612	26.3	818	1056	1032	7.86e-48	189	ITA4_HUMAN	Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)	Homo sapiens (Human)	axonogenesis involved in innervation [GO:0060385]; B cell differentiation [GO:0030183]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cell-matrix adhesion involved in ameboidal cell migration [GO:0003366]; cellular response to amyloid-beta [GO:1904646]; cellular response to cytokine stimulus [GO:0071345]; clathrin-dependent extracellular exosome endocytosis [GO:1990771]; diapedesis [GO:0050904]; endodermal cell differentiation [GO:0035987]; heterotypic cell-cell adhesion [GO:0034113]; immune response in gut-associated lymphoid tissue [GO:0002387]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; negative regulation of vasoconstriction [GO:0045906]; neuron projection extension [GO:1990138]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of T cell migration [GO:2000406]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; receptor clustering [GO:0043113]; substrate adhesion-dependent cell spreading [GO:0034446]	cell adhesion molecule binding [GO:0050839]; coreceptor activity [GO:0015026]; fibronectin binding [GO:0001968]; integrin binding [GO:0005178]; protein antigen binding [GO:1990405]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; integrin alpha4-beta1 complex [GO:0034668]; integrin alpha4-beta7 complex [GO:0034669]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	GO:0001968; GO:0002387; GO:0003366; GO:0005178; GO:0005886; GO:0005925; GO:0007159; GO:0007160; GO:0007229; GO:0009986; GO:0015026; GO:0016020; GO:0030183; GO:0030426; GO:0033631; GO:0034113; GO:0034446; GO:0034668; GO:0034669; GO:0035987; GO:0038023; GO:0043025; GO:0043113; GO:0045906; GO:0050839; GO:0050901; GO:0050904; GO:0060385; GO:0070062; GO:0071345; GO:0098609; GO:1903238; GO:1904646; GO:1905564; GO:1990138; GO:1990405; GO:1990771; GO:2000353; GO:2000406
GN000837	GN000837.1	P0DXB9	59.8	356	556	587	2.25e-145	434	CGLR_MAGGI	Cyclic GMP-AMP synthase-like receptor (Cg-cGLR) (Cyclic UMP-AMP synthase cGLR) (EC 2.7.7.-)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		double-stranded DNA binding [GO:0003690]		GO:0003690
GN000838	GN000838.1	Q15582	26.7	247	315	683	2.31e-19	92.0	BGH3_HUMAN	Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (Kerato-epithelin) (RGD-containing collagen-associated protein) (RGD-CAP)	Homo sapiens (Human)	angiogenesis [GO:0001525]; cell population proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; extracellular matrix organization [GO:0030198]; homophilic cell-cell adhesion [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; visual perception [GO:0007601]	cell adhesion molecule binding [GO:0050839]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]	elastic fiber [GO:0071953]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GO:0001525; GO:0002062; GO:0005178; GO:0005201; GO:0005518; GO:0005576; GO:0005802; GO:0005886; GO:0007156; GO:0007162; GO:0007601; GO:0008283; GO:0030198; GO:0031012; GO:0042802; GO:0050839; GO:0050840; GO:0070062; GO:0071953; GO:0140144
GN000840	GN000840.1	Q6AY20	34.8	112	238	278	3.66e-10	62.0	MPRD_RAT	Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR)	Rattus norvegicus (Rat)	Golgi to lysosome transport [GO:0090160]; lysosomal transport [GO:0007041]; protein targeting to lysosome [GO:0006622]; secretion of lysosomal enzymes [GO:0033299]	cargo receptor activity [GO:0038024]; protein domain specific binding [GO:0019904]; retromer complex binding [GO:1905394]	cytosol [GO:0005829]; endosome [GO:0005768]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802]	GO:0005765; GO:0005768; GO:0005770; GO:0005802; GO:0005829; GO:0006622; GO:0007041; GO:0019904; GO:0033299; GO:0038024; GO:0048471; GO:0090160; GO:1905394
GN000842	GN000842.1	O42603	44.3	366	437	413	4.94e-89	279	CRHR2_XENLA	Corticotropin-releasing hormone receptor 2 (CRH-R-2) (CRH-R2) (Corticotropin-releasing factor receptor 2) (CRF-R-2) (CRF-R2) (CRFR-2)	Xenopus laevis (African clawed frog)	adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; long-term synaptic potentiation [GO:0060291]	corticotrophin-releasing factor receptor activity [GO:0015056]; corticotropin-releasing hormone receptor activity [GO:0043404]; G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]	axon terminus [GO:0043679]; dendrite [GO:0030425]; plasma membrane [GO:0005886]	GO:0005886; GO:0007166; GO:0007188; GO:0008528; GO:0015056; GO:0017046; GO:0030425; GO:0043404; GO:0043679; GO:0060291
GN000846	GN000846.1	Q5F485	63.5	716	730	944	1.30e-304	860	DDX42_CHICK	ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42)	Gallus gallus (Chicken)	intracellular protein localization [GO:0008104]; regulation of apoptotic process [GO:0042981]; U2-type prespliceosome assembly [GO:1903241]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; U2-type prespliceosome [GO:0071004]	GO:0003676; GO:0003724; GO:0005524; GO:0005634; GO:0005737; GO:0008104; GO:0016887; GO:0042981; GO:0071004; GO:1903241
GN000848	GN000848.1	Q8R205	37.6	415	404	435	9.32e-64	213	ZC3HA_MOUSE	Zinc finger CCCH domain-containing protein 10	Mus musculus (Mouse)	negative regulation of miRNA processing [GO:1903799]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of RNA splicing [GO:0043484]	metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]	nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0010608; GO:0035198; GO:0043484; GO:0046872; GO:1903799
GN000853	GN000853.1	P56479	26.0	288	372	348	3.64e-25	107	GALR1_MOUSE	Galanin receptor type 1 (GAL1-R) (GALR-1)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cortisol secretion [GO:0051464]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transcription by RNA polymerase II [GO:0045944]	galanin receptor activity [GO:0004966]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]	plasma membrane [GO:0005886]	GO:0004966; GO:0005886; GO:0007186; GO:0007189; GO:0007204; GO:0007218; GO:0017046; GO:0042923; GO:0045944; GO:0051464
GN000859	GN000859.1	Q60997	31.0	229	386	2085	4.60e-15	80.9	DMBT1_MOUSE	Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Apactin) (CRP-ductin) (Deleted in malignant brain tumors 1 protein) (Glycoprotein 300) (gp300) (Hensin) (Mucin-like glycoprotein) (Muclin) (Vomeroglandin) (p80)	Mus musculus (Mouse)	antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; blastocyst development [GO:0001824]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; induction of bacterial agglutination [GO:0043152]; inner cell mass cell proliferation [GO:0001833]; positive regulation of epithelial cell differentiation [GO:0030858]; receptor-mediated endocytosis [GO:0006898]; response to bacterium [GO:0009617]	DNA binding [GO:0003677]; heparan sulfate binding [GO:1904399]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]; phagocytic vesicle membrane [GO:0030670]; transport vesicle membrane [GO:0030658]; zymogen granule membrane [GO:0042589]	GO:0001530; GO:0001824; GO:0001833; GO:0003677; GO:0005044; GO:0005576; GO:0005737; GO:0006898; GO:0009617; GO:0030658; GO:0030670; GO:0030858; GO:0031012; GO:0035375; GO:0038187; GO:0042589; GO:0043152; GO:0050829; GO:0050830; GO:0061844; GO:0070891; GO:0140144; GO:1904399
GN000861	GN000861.1	P31597	69.5	167	172	524	1.09e-66	214	EAA3_RABIT	Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1)	Oryctolagus cuniculus (Rabbit)	chloride transmembrane transport [GO:1902476]; D-aspartate import across plasma membrane [GO:0070779]; L-aspartate import across plasma membrane [GO:0140009]; L-cysteine transport [GO:0042883]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]	chloride transmembrane transporter activity [GO:0015108]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-cysteine transmembrane transporter activity [GO:0033229]; L-glutamate transmembrane transporter activity [GO:0005313]	apical plasma membrane [GO:0016324]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202]	GO:0005313; GO:0005314; GO:0005886; GO:0015108; GO:0015501; GO:0015813; GO:0016324; GO:0031901; GO:0031902; GO:0033229; GO:0042883; GO:0045202; GO:0055038; GO:0070779; GO:0098712; GO:0140009; GO:1902476
GN000865	GN000865.1	Q9Z0J1	45.3	86	193	971	2.94e-17	82.4	RECK_MOUSE	Reversion-inducing cysteine-rich protein with Kazal motifs (mRECK)	Mus musculus (Mouse)	blood vessel maturation [GO:0001955]; canonical Wnt signaling pathway [GO:0060070]; embryo implantation [GO:0007566]; embryonic forelimb morphogenesis [GO:0035115]; extracellular matrix organization [GO:0030198]; negative regulation of cell migration [GO:0030336]; negative regulation of extracellular matrix disassembly [GO:0010716]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of angiogenesis [GO:0045765]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of establishment of blood-brain barrier [GO:0090210]; regulation of extracellular matrix organization [GO:1903053]; sprouting angiogenesis [GO:0002040]	coreceptor activity [GO:0015026]; endopeptidase inhibitor activity [GO:0004866]; metalloendopeptidase inhibitor activity [GO:0008191]; Wnt-protein binding [GO:0017147]	plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; Wnt signalosome [GO:1990909]	GO:0001955; GO:0002040; GO:0004866; GO:0005886; GO:0007566; GO:0008191; GO:0010716; GO:0015026; GO:0017147; GO:0030198; GO:0030336; GO:0035115; GO:0042986; GO:0044853; GO:0045765; GO:0060070; GO:0060828; GO:0090210; GO:0090263; GO:1902004; GO:1903053; GO:1990909
GN000869	GN000869.1	Q91085	39.2	273	476	457	3.50e-47	172	VIPR_MELGA	Vasoactive intestinal polypeptide receptor (VIP receptor) (VIP-R)	Meleagris gallopavo (Wild turkey)	adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]	G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; vasoactive intestinal polypeptide receptor activity [GO:0004999]	plasma membrane [GO:0005886]	GO:0004999; GO:0005886; GO:0007166; GO:0007188; GO:0008528; GO:0017046
GN000871	GN000871.1	Q14191	34.4	131	176	1432	3.48e-13	70.1	WRN_HUMAN	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Homo sapiens (Human)	base-excision repair [GO:0006284]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; mismatch repair [GO:0006298]; positive regulation of strand invasion [GO:0098530]; protein localization to nucleolus [GO:1902570]; replication fork processing [GO:0031297]; response to UV-C [GO:0010225]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; 3'-flap-structured DNA binding [GO:0070337]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bubble DNA binding [GO:0000405]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; exonuclease activity [GO:0004527]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MutLalpha complex binding [GO:0032405]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]	centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000287; GO:0000400; GO:0000403; GO:0000405; GO:0000723; GO:0000731; GO:0000781; GO:0003677; GO:0003678; GO:0004527; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005730; GO:0005737; GO:0005813; GO:0006259; GO:0006260; GO:0006284; GO:0006298; GO:0006302; GO:0006310; GO:0006974; GO:0008408; GO:0009267; GO:0009378; GO:0010225; GO:0016607; GO:0016887; GO:0030145; GO:0031297; GO:0032201; GO:0032392; GO:0032405; GO:0042803; GO:0043138; GO:0044877; GO:0051880; GO:0061749; GO:0061820; GO:0061821; GO:0061849; GO:0070337; GO:0071480; GO:0090398; GO:0090656; GO:0098530; GO:1902570; GO:1905773
GN000872	GN000872.1	Q08EN7	35.5	124	410	331	3.36e-19	91.3	ZCPW2_MOUSE	Zinc finger CW-type PWWP domain protein 2 homolog	Mus musculus (Mouse)		histone H3K4me3 reader activity [GO:0140002]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0005634; GO:0008270; GO:0140002
GN000873	GN000873.1	Q99NH2	34.5	863	1020	1333	1.98e-84	301	PARD3_MOUSE	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP)	Mus musculus (Mouse)	apical constriction [GO:0003383]; bicellular tight junction assembly [GO:0070830]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; centrosome localization [GO:0051642]; establishment of cell polarity [GO:0030010]; establishment of epithelial cell polarity [GO:0090162]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular protein localization [GO:0008104]; microtubule cytoskeleton organization [GO:0000226]; myelination in peripheral nervous system [GO:0022011]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; positive regulation of myelination [GO:0031643]; positive regulation of receptor internalization [GO:0002092]; protein targeting to membrane [GO:0006612]; regulation of actin filament-based process [GO:0032970]; regulation of cellular localization [GO:0060341]; wound healing, spreading of cells [GO:0044319]	identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein phosphatase binding [GO:0019903]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; axonal growth cone [GO:0044295]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; internode region of axon [GO:0033269]; lateral loop [GO:0043219]; neuronal cell body [GO:0043025]; PAR polarity complex [GO:0120157]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; Schmidt-Lanterman incisure [GO:0043220]; spindle [GO:0005819]	GO:0000226; GO:0002092; GO:0003383; GO:0005546; GO:0005547; GO:0005737; GO:0005819; GO:0005886; GO:0005911; GO:0005912; GO:0005923; GO:0005938; GO:0006612; GO:0007155; GO:0007163; GO:0008104; GO:0010801; GO:0012505; GO:0016324; GO:0019903; GO:0022011; GO:0030010; GO:0030054; GO:0031643; GO:0032266; GO:0032970; GO:0032991; GO:0033269; GO:0035091; GO:0042802; GO:0043025; GO:0043219; GO:0043220; GO:0043296; GO:0044295; GO:0044319; GO:0045197; GO:0051642; GO:0060341; GO:0070161; GO:0070830; GO:0090162; GO:0098609; GO:0120157
GN000876	GN000876.1	Q91VD9	72.4	718	793	727	0.0	1060	NDUS1_MOUSE	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 7.1.1.2) (Complex I-75kD) (CI-75kD)	Mus musculus (Mouse)	aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]	electron transfer activity [GO:0009055]; iron-sulfur cluster binding [GO:0051536]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; respiratory chain complex I [GO:0045271]	GO:0005739; GO:0005743; GO:0005758; GO:0006120; GO:0008137; GO:0009055; GO:0009060; GO:0032981; GO:0042776; GO:0043209; GO:0045271; GO:0045333; GO:0051536
GN000897	GN000897.1	D3YZI9	32.2	121	251	523	6.73e-09	59.3	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN000903	GN000903.1	P40724	28.4	433	461	609	9.10e-43	162	RECQ_SALTY	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]	GO:0003676; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0009432; GO:0016887; GO:0030894; GO:0043138; GO:0043590
GN000910	GN000910.1	Q55E58	24.2	302	1173	3184	1.53e-11	73.2	PATS1_DICDI	Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1)	Dictyostelium discoideum (Social amoeba)	cheating during chimeric sorocarp development [GO:0099139]; mitotic cytokinesis [GO:0000281]; phosphatidylinositol dephosphorylation [GO:0046856]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actomyosin [GO:0042641]; cytosol [GO:0005829]; membrane [GO:0016020]	GO:0000281; GO:0004438; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0005829; GO:0016020; GO:0042641; GO:0046856; GO:0099139; GO:0106310
GN000917	GN000917.1	P83939	34.9	415	413	414	4.97e-72	234	SCRN1_BOVIN	Secernin-1 (p50)	Bos taurus (Bovine)	exocytosis [GO:0006887]; proteolysis [GO:0006508]	cysteine-type exopeptidase activity [GO:0070004]; dipeptidase activity [GO:0016805]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]	GO:0005737; GO:0006508; GO:0006887; GO:0016805; GO:0031965; GO:0070004
GN000918	GN000918.1	Q7ZVY5	80.0	390	431	468	7.24e-242	670	CISY_DANRE	Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase)	Danio rerio (Zebrafish) (Brachydanio rerio)	carbohydrate metabolic process [GO:0005975]; citrate metabolic process [GO:0006101]; response to activity [GO:0014823]; tricarboxylic acid cycle [GO:0006099]	citrate synthase activity [GO:0036440]; identical protein binding [GO:0042802]	mitochondrial matrix [GO:0005759]	GO:0005759; GO:0005975; GO:0006099; GO:0006101; GO:0014823; GO:0036440; GO:0042802
GN000924	GN000924.1	P26221	44.7	255	246	880	4.94e-63	214	GUN4_THEFU	Endoglucanase E-4 (EC 3.2.1.4) (Cellulase E-4) (Cellulase E4) (Endo-1,4-beta-glucanase E-4)	Thermobifida fusca (Thermomonospora fusca)	cellulose catabolic process [GO:0030245]	cellulase activity [GO:0008810]; cellulose binding [GO:0030248]		GO:0008810; GO:0030245; GO:0030248
GN000926	GN000926.1	P26221	49.2	317	423	880	3.87e-94	305	GUN4_THEFU	Endoglucanase E-4 (EC 3.2.1.4) (Cellulase E-4) (Cellulase E4) (Endo-1,4-beta-glucanase E-4)	Thermobifida fusca (Thermomonospora fusca)	cellulose catabolic process [GO:0030245]	cellulase activity [GO:0008810]; cellulose binding [GO:0030248]		GO:0008810; GO:0030245; GO:0030248
GN000927	GN000927.1	Q02934	50.4	127	131	887	3.49e-31	119	GUNI_ACET2	Endoglucanase 1 (EC 3.2.1.4) (Cellulase I) (Endo-1,4-beta-glucanase) (Endoglucanase I) (EGI)	Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)	cellulose catabolic process [GO:0030245]	cellulase activity [GO:0008810]; cellulose binding [GO:0030248]; identical protein binding [GO:0042802]		GO:0008810; GO:0030245; GO:0030248; GO:0042802
GN000931	GN000931.1	Q5EAR6	29.2	195	190	206	1.29e-17	80.1	VMA22_DANRE	Vacuolar ATPase assembly protein VMA22 (Coiled-coil domain-containing protein 115)	Danio rerio (Zebrafish) (Brachydanio rerio)	intracellular iron ion homeostasis [GO:0006879]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]		COPI-coated vesicle [GO:0030137]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; lysosome [GO:0005764]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]	GO:0005764; GO:0005768; GO:0005783; GO:0005793; GO:0006879; GO:0016471; GO:0030137; GO:0070072
GN000932	GN000932.1	Q6PDJ6	48.5	332	603	717	1.53e-109	347	FBX42_MOUSE	F-box only protein 42	Mus musculus (Mouse)		ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	SCF ubiquitin ligase complex [GO:0019005]	GO:0019005; GO:1990756
GN000933	GN000933.1	Q5ZL00	35.5	203	218	983	1.10e-32	127	EMC1_CHICK	ER membrane protein complex subunit 1	Gallus gallus (Chicken)	protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]		EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0005789; GO:0016020; GO:0045050; GO:0071816; GO:0072546
GN000934	GN000934.1	O95407	26.8	179	419	300	6.84e-13	72.4	TNF6B_HUMAN	Tumor necrosis factor receptor superfamily member 6B (Decoy receptor 3) (DcR3) (Decoy receptor for Fas ligand) (M68)	Homo sapiens (Human)	negative regulation of apoptotic process [GO:0043066]; negative regulation of inflammatory response [GO:0050728]	receptor decoy activity [GO:0140319]	decoy receptor complex [GO:0140368]; extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020; GO:0043066; GO:0050728; GO:0140319; GO:0140368
GN000939	GN000939.1	P9WEL6	24.4	295	345	308	6.87e-18	86.3	AVAO_ASPVE	Ava biosynthesis cluster protein O	Aspergillus versicolor				
GN000947	GN000947.1	A4WFX9	31.9	191	835	260	2.16e-12	71.6	TATD_ENT38	3'-5' ssDNA/RNA exonuclease TatD (EC 3.1.11.-) (EC 3.1.13.-) (DNase TatD)	Enterobacter sp. (strain 638)		3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]	cytosol [GO:0005829]	GO:0000175; GO:0000287; GO:0005829; GO:0008310
GN000949	GN000949.1	Q49LX5	38.7	75	190	391	4.24e-10	61.2	SSR1_CANLF	Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R)	Canis lupus familiaris (Dog) (Canis familiaris)		somatostatin receptor activity [GO:0004994]	plasma membrane [GO:0005886]	GO:0004994; GO:0005886
GN000953	GN000953.1	P97714	36.9	122	141	562	5.66e-16	76.6	ADA1D_MOUSE	Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor)	Mus musculus (Mouse)	adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; cell-cell signaling [GO:0007267]; negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure [GO:0001986]; neuron-glial cell signaling [GO:0150099]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of vasoconstriction [GO:0045907]; regulation of blood pressure [GO:0008217]	alpha1-adrenergic receptor activity [GO:0004937]; identical protein binding [GO:0042802]	plasma membrane [GO:0005886]	GO:0001986; GO:0001994; GO:0004937; GO:0005886; GO:0007200; GO:0007204; GO:0007267; GO:0008217; GO:0042802; GO:0043410; GO:0045907; GO:0071880; GO:0150099
GN000969	GN000969.1	Q5AXT5	34.3	201	258	745	1.33e-28	117	PIF1_EMENI	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]	GO:0000723; GO:0003697; GO:0005524; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0043139; GO:0043596; GO:0071932
GN000973	GN000973.1	O15254	56.4	693	723	700	5.98e-283	795	ACOX3_HUMAN	Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase)	Homo sapiens (Human)	fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]	acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; long-chain fatty acyl-CoA oxidase activity [GO:0120524]; medium-chain fatty acyl-CoA oxidase activity [GO:0120523]; pristanoyl-CoA oxidase activity [GO:0016402]; very-long-chain fatty acyl-CoA oxidase activity [GO:0044535]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0003997; GO:0005504; GO:0005777; GO:0005782; GO:0005829; GO:0016020; GO:0016402; GO:0033540; GO:0044535; GO:0050660; GO:0071949; GO:0120523; GO:0120524
GN000974	GN000974.1	Q8K2A8	61.3	93	102	438	7.03e-31	115	ALG3_MOUSE	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Asparagine-linked glycosylation protein 3 homolog) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase) (Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase) (Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase)	Mus musculus (Mouse)	dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]	dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0052925]	endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0006487; GO:0006488; GO:0052925
GN000975	GN000975.1	Q64737	57.8	618	607	1010	2.29e-234	678	PUR2_MOUSE	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]	Mus musculus (Mouse)	'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; adenine biosynthetic process [GO:0046084]; brainstem development [GO:0003360]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; GMP biosynthetic process [GO:0006177]; purine nucleotide biosynthetic process [GO:0006164]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylamine-glycine ligase activity [GO:0004637]; phosphoribosylformylglycinamidine cyclo-ligase activity [GO:0004641]; phosphoribosylglycinamide formyltransferase activity [GO:0004644]	cytosol [GO:0005829]	GO:0003360; GO:0004637; GO:0004641; GO:0004644; GO:0005524; GO:0005829; GO:0006164; GO:0006177; GO:0006189; GO:0021549; GO:0021987; GO:0044208; GO:0046084; GO:0046872; GO:0097294
GN000982	GN000982.1	Q9FGH2	29.7	145	357	182	4.80e-10	61.6	LSH5_ARATH	Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 5 (Protein ORGAN BOUNDARY 5)	Arabidopsis thaliana (Mouse-ear cress)	mRNA transcription [GO:0009299]; post-embryonic plant morphogenesis [GO:0090698]		nucleus [GO:0005634]	GO:0005634; GO:0009299; GO:0090698
GN000989	GN000989.1	Q49LX5	37.2	78	190	391	3.13e-10	61.6	SSR1_CANLF	Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R)	Canis lupus familiaris (Dog) (Canis familiaris)		somatostatin receptor activity [GO:0004994]	plasma membrane [GO:0005886]	GO:0004994; GO:0005886
GN000992	GN000992.1	Q6NVR9	59.0	442	442	594	3.60e-158	462	ATAD3_XENTR	ATPase family AAA domain-containing protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mitochondrion organization [GO:0007005]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	GO:0005524; GO:0005739; GO:0005743; GO:0007005; GO:0016887; GO:0042645
GN000993	GN000993.1	Q13489	33.1	239	250	604	5.74e-24	103	BIRC3_HUMAN	Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)	Homo sapiens (Human)	canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; spermatogenesis [GO:0007283]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; protein-containing complex binding [GO:0044877]; transferase activity [GO:0016740]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; tumor necrosis factor receptor superfamily complex [GO:0002947]	GO:0002947; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006954; GO:0007166; GO:0007249; GO:0007283; GO:0008625; GO:0008630; GO:0016740; GO:0031398; GO:0033209; GO:0034121; GO:0038061; GO:0039535; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0044877; GO:0045088; GO:0050727; GO:0051726; GO:0060544; GO:0060546; GO:0061630; GO:0070424
GN000994	GN000994.1	Q13489	30.4	240	255	604	4.80e-24	103	BIRC3_HUMAN	Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)	Homo sapiens (Human)	canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; spermatogenesis [GO:0007283]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; protein-containing complex binding [GO:0044877]; transferase activity [GO:0016740]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; tumor necrosis factor receptor superfamily complex [GO:0002947]	GO:0002947; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006954; GO:0007166; GO:0007249; GO:0007283; GO:0008625; GO:0008630; GO:0016740; GO:0031398; GO:0033209; GO:0034121; GO:0038061; GO:0039535; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0044877; GO:0045088; GO:0050727; GO:0051726; GO:0060544; GO:0060546; GO:0061630; GO:0070424
GN000995	GN000995.1	P41437	54.4	79	654	268	1.03e-20	95.9	IAP3_NPVOP	E3 ubiquitin-protein ligase IAP-3 (EC 2.3.2.27) (IAP-3) (RING-type E3 ubiquitin transferase IAP-3)	Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV)	symbiont-mediated perturbation of host ubiquitin-like protein modification [GO:0039648]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]		GO:0008270; GO:0039648; GO:0061630
GN000999	GN000999.1	Q6NW29	48.7	187	184	188	2.37e-55	176	RWDD4_HUMAN	RWD domain-containing protein 4 (Protein FAM28A)	Homo sapiens (Human)				
GN001000	GN001000.1	Q5ZI89	53.5	930	890	1132	0.0	949	TPC11_CHICK	Trafficking protein particle complex subunit 11	Gallus gallus (Chicken)			Golgi apparatus [GO:0005794]	GO:0005794
GN001001	GN001001.1	Q5ZI89	43.0	200	201	1132	6.46e-44	159	TPC11_CHICK	Trafficking protein particle complex subunit 11	Gallus gallus (Chicken)			Golgi apparatus [GO:0005794]	GO:0005794
GN001004	GN001004.1	A0AUT1	42.5	414	498	499	2.32e-71	238	TCHP_XENLA	Trichoplein keratin filament-binding protein (Protein TCHP)	Xenopus laevis (African clawed frog)	apoptotic process [GO:0006915]		centrosome [GO:0005813]; keratin filament [GO:0045095]	GO:0005813; GO:0006915; GO:0045095
GN001005	GN001005.1	Q5FW48	57.0	277	267	284	8.41e-102	301	ASPDH_XENTR	Aspartate dehydrogenase domain-containing protein	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	NAD+ biosynthetic process [GO:0009435]	L-aspartate dehydrogenase [NAD(P)+] activity [GO:0033735]; NADP binding [GO:0050661]		GO:0009435; GO:0033735; GO:0050661
GN001006	GN001006.1	Q9BY10	24.2	409	502	475	1.22e-19	95.1	S46A2_HUMAN	Solute carrier family 46 member 2 (Thymic stromal cotransporter homolog)	Homo sapiens (Human)	cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; transmembrane transport [GO:0055085]	cyclic-GMP-AMP transmembrane transporter activity [GO:0140360]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]	cell surface [GO:0009986]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0009986; GO:0010008; GO:0015293; GO:0016020; GO:0022857; GO:0055085; GO:0070430; GO:0140360; GO:0140361
GN001027	GN001027.1	Q5F2F2	35.7	350	388	459	4.88e-55	191	ABH15_MOUSE	Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15)	Mus musculus (Mouse)	adipose tissue development [GO:0060612]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]	monoacylglycerol lipase activity [GO:0047372]; short-chain carboxylesterase activity [GO:0034338]	extracellular region [GO:0005576]	GO:0005576; GO:0006629; GO:0016042; GO:0034338; GO:0047372; GO:0060612
GN001029	GN001029.1	A7MCB7	47.9	165	196	194	7.00e-41	140	TMA16_DANRE	Translation machinery-associated protein 16	Danio rerio (Zebrafish) (Brachydanio rerio)	ribosomal large subunit biogenesis [GO:0042273]	preribosome binding [GO:1990275]	nucleus [GO:0005634]	GO:0005634; GO:0042273; GO:1990275
GN001031	GN001031.1	Q9NRA2	41.6	471	564	495	1.58e-126	383	S17A5_HUMAN	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)	Homo sapiens (Human)	carbohydrate derivative transport [GO:1901264]; monoatomic anion transport [GO:0006820]; neurotransmitter loading into synaptic vesicle [GO:0098700]; sialic acid transport [GO:0015739]	carbohydrate:proton symporter activity [GO:0005351]; D-glucuronate transmembrane transporter activity [GO:0042880]; glucuronate transmembrane transporter activity [GO:0015135]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	GO:0005351; GO:0005764; GO:0005765; GO:0005886; GO:0006820; GO:0015135; GO:0015136; GO:0015538; GO:0015739; GO:0016020; GO:0016323; GO:0016324; GO:0030672; GO:0042880; GO:0098700; GO:0098978; GO:1901264
GN001032	GN001032.1	Q5E9F9	93.1	433	433	433	1.11e-297	810	PRS7_BOVIN	26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2)	Bos taurus (Bovine)	ubiquitin-dependent protein catabolic process [GO:0006511]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]	GO:0000502; GO:0000932; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006511; GO:0016887; GO:0022624; GO:0036402
GN001034	GN001034.1	O12947	51.9	287	295	288	4.14e-98	293	ICMT_XENLA	Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Farnesyl cysteine carboxyl methyltransferase) (FCMT) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT)	Xenopus laevis (African clawed frog)		protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity [GO:0004671]	endoplasmic reticulum membrane [GO:0005789]	GO:0004671; GO:0005789
GN001037	GN001037.1	Q4J9D2	45.9	135	391	181	2.51e-33	125	Y1252_SULAC	Uncharacterized protein Saci_1252	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)				
GN001038	GN001038.1	Q8N9I9	49.2	191	1230	347	4.62e-53	193	DTX3_HUMAN	E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)	Homo sapiens (Human)	Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0007219; GO:0008593; GO:0016567; GO:0061630
GN001040	GN001040.1	Q71W03	38.7	168	280	176	1.08e-28	110	Y2748_LISMF	Macro domain-containing protein LMOf2365_2748	Listeria monocytogenes serotype 4b (strain F2365)				
GN001042	GN001042.1	Q460N5	31.8	355	989	1801	1.66e-34	147	PAR14_HUMAN	Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14)	Homo sapiens (Human)	NAD+ catabolic process [GO:0019677]; negative regulation of gene expression [GO:0010629]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein poly-ADP-ribosylation [GO:0070212]	enzyme binding [GO:0019899]; NAD+ binding [GO:0070403]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0003714; GO:0003950; GO:0005634; GO:0005737; GO:0005829; GO:0010629; GO:0016020; GO:0019677; GO:0019899; GO:0042531; GO:0042532; GO:0060336; GO:0070212; GO:0070403; GO:0140807; GO:1902216; GO:1990404
GN001043	GN001043.1	Q8TDB6	44.0	200	993	740	4.63e-43	172	DTX3L_HUMAN	E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)	Homo sapiens (Human)	DNA damage checkpoint signaling [GO:0000077]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; endosome to lysosome transport [GO:0008333]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; Notch signaling pathway [GO:0007219]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor catabolic process [GO:2000646]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone H4K91 ubiquitin ligase activity [GO:0141000]; histone ubiquitin ligase activity [GO:0140852]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]; STAT family protein binding [GO:0097677]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000077; GO:0002230; GO:0004842; GO:0004857; GO:0005634; GO:0005654; GO:0005737; GO:0005764; GO:0005765; GO:0005829; GO:0006302; GO:0006511; GO:0007219; GO:0008333; GO:0016567; GO:0019899; GO:0031901; GO:0032092; GO:0032991; GO:0035563; GO:0042393; GO:0044389; GO:0045893; GO:0051444; GO:0051865; GO:0061630; GO:0070936; GO:0097677; GO:0140768; GO:0140852; GO:0140861; GO:0141000; GO:1900182; GO:1902966; GO:2000646
GN001044	GN001044.1	Q460N5	31.7	356	707	1801	1.58e-35	148	PAR14_HUMAN	Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14)	Homo sapiens (Human)	NAD+ catabolic process [GO:0019677]; negative regulation of gene expression [GO:0010629]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein poly-ADP-ribosylation [GO:0070212]	enzyme binding [GO:0019899]; NAD+ binding [GO:0070403]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0003714; GO:0003950; GO:0005634; GO:0005737; GO:0005829; GO:0010629; GO:0016020; GO:0019677; GO:0019899; GO:0042531; GO:0042532; GO:0060336; GO:0070212; GO:0070403; GO:0140807; GO:1902216; GO:1990404
GN001046	GN001046.1	Q3T0E7	93.0	329	328	330	9.12e-233	637	PP1A_BOVIN	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)	Bos taurus (Bovine)	circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000806]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein dephosphorylation [GO:0006470]; protein stabilization [GO:0050821]; regulation of circadian rhythm [GO:0042752]; RNA polymerase II promoter clearance [GO:0001111]; telomere maintenance in response to DNA damage [GO:0043247]	cadherin binding involved in cell-cell adhesion [GO:0098641]; iron ion binding [GO:0005506]; phosphatase activity [GO:0016791]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; transition metal ion binding [GO:0046914]	adherens junction [GO:0005912]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; PTW/PP1 phosphatase complex [GO:0072357]	GO:0000781; GO:0001111; GO:0004722; GO:0005506; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005783; GO:0005829; GO:0005912; GO:0006470; GO:0014069; GO:0016791; GO:0032922; GO:0032968; GO:0034244; GO:0042752; GO:0043153; GO:0043247; GO:0045725; GO:0046914; GO:0050821; GO:0072357; GO:0098641; GO:0180007; GO:2000806
GN001047	GN001047.1	G5EFC3	36.3	215	293	558	1.06e-35	137	KCNAG_CAEEL	Potassium voltage-gated channel protein egl-36 (Egg-laying defective protein 36)	Caenorhabditis elegans	action potential [GO:0001508]; monoatomic ion transmembrane transport [GO:0034220]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic ion channel activity [GO:0005244]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005244; GO:0005251; GO:0008076; GO:0016020; GO:0032590; GO:0032809; GO:0034220; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN001048	GN001048.1	P42575	43.0	172	528	452	2.25e-34	138	CASP2_HUMAN	Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]	Homo sapiens (Human)	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; luteolysis [GO:0001554]; negative regulation of apoptotic process [GO:0043066]; neural retina development [GO:0003407]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]	cysteine-type endopeptidase activity [GO:0004197]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0001554; GO:0003407; GO:0004197; GO:0005634; GO:0005730; GO:0005737; GO:0005739; GO:0005829; GO:0006915; GO:0006974; GO:0008630; GO:0016485; GO:0019899; GO:0019904; GO:0030330; GO:0042802; GO:0043065; GO:0043066; GO:0043525; GO:0071260; GO:0097190; GO:0097192; GO:0097194; GO:1905369
GN001049	GN001049.1	A9UUB8	40.7	300	302	333	2.32e-64	208	FUCT1_MONBE	GDP-fucose transporter 1 (Solute carrier family 35 member C1 homolog)	Monosiga brevicollis (Choanoflagellate)	GDP-fucose import into Golgi lumen [GO:0036085]	GDP-fucose transmembrane transporter activity [GO:0005457]	Golgi membrane [GO:0000139]	GO:0000139; GO:0005457; GO:0036085
GN001050	GN001050.1	H9J9M0	35.1	276	318	539	7.57e-49	174	CDA1_BOMMO	Chitin deacetylase 1 (BmCDA1) (EC 3.5.1.41)	Bombyx mori (Silk moth)	polysaccharide catabolic process [GO:0000272]	chitin binding [GO:0008061]; chitin deacetylase activity [GO:0004099]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0000272; GO:0004099; GO:0005576; GO:0008061; GO:0008270
GN001051	GN001051.1	Q8WZA0	63.8	141	141	190	6.21e-52	166	LZIC_HUMAN	Protein LZIC (Leucine zipper and CTNNBIP1 domain-containing protein) (Leucine zipper and ICAT homologous domain-containing protein)	Homo sapiens (Human)	response to ionizing radiation [GO:0010212]	beta-catenin binding [GO:0008013]		GO:0008013; GO:0010212
GN001052	GN001052.1	P42674	37.7	395	490	597	6.78e-70	236	BP10_PARLI	Blastula protease 10 (EC 3.4.24.-)	Paracentrotus lividus (Common sea urchin)	molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]	GO:0004222; GO:0005576; GO:0005938; GO:0006508; GO:0008270; GO:0018996; GO:0048471
GN001053	GN001053.1	O35130	75.5	204	228	244	3.32e-108	314	NEP1_MOUSE	Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.-) (18S rRNA (pseudouridine(1248)-N1)-methyltransferase) (18S rRNA Psi1248 methyltransferase) (Nucleolar protein EMG1 homolog) (Protein C2f) (Ribosome biogenesis protein NEP1)	Mus musculus (Mouse)	blastocyst development [GO:0001824]; nucleologenesis [GO:0017126]; ribosomal small subunit biogenesis [GO:0042274]; rRNA base methylation [GO:0070475]	identical protein binding [GO:0042802]; rRNA (pseudouridine) methyltransferase activity [GO:0070037]; rRNA binding [GO:0019843]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	GO:0001824; GO:0005654; GO:0005694; GO:0005730; GO:0017126; GO:0019843; GO:0032040; GO:0042274; GO:0042802; GO:0070037; GO:0070475
GN001054	GN001054.1	P40720	66.0	535	560	580	7.57e-265	738	FUMA_SALTY	Fumarate hydratase class I, aerobic (EC 4.2.1.2) (Fumarase A) (Oxaloacetate keto--enol-isomerase) (OAAKE isomerase) (Oxaloacetate tautomerase) (EC 5.3.2.2)	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	tricarboxylic acid cycle [GO:0006099]	4 iron, 4 sulfur cluster binding [GO:0051539]; fumarate hydratase activity [GO:0004333]; oxaloacetate tautomerase activity [GO:0050163]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]	GO:0004333; GO:0005829; GO:0006099; GO:0042803; GO:0050163; GO:0051539
GN001056	GN001056.1	Q05BC3	37.3	405	417	814	3.07e-82	271	EMAL1_MOUSE	Echinoderm microtubule-associated protein-like 1 (EMAP-1)	Mus musculus (Mouse)	brain development [GO:0007420]; hematopoietic progenitor cell differentiation [GO:0002244]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; neuroblast proliferation [GO:0007405]	microtubule binding [GO:0008017]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; perinuclear region of cytoplasm [GO:0048471]	GO:0000226; GO:0002244; GO:0005737; GO:0005829; GO:0005874; GO:0007052; GO:0007405; GO:0007420; GO:0008017; GO:0015631; GO:0048471
GN001057	GN001057.1	O15075	30.3	188	282	740	4.13e-16	81.6	DCLK1_HUMAN	Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)	Homo sapiens (Human)	axon extension [GO:0048675]; central nervous system development [GO:0007417]; endosomal transport [GO:0016197]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; protein phosphorylation [GO:0006468]; response to virus [GO:0009615]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005886; GO:0006468; GO:0007399; GO:0007417; GO:0009615; GO:0016197; GO:0035556; GO:0048675; GO:0106310
GN001061	GN001061.1	P48548	40.1	327	405	419	1.47e-83	264	KCNJ5_RAT	G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)	Rattus norvegicus (Rat)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]	external side of plasma membrane [GO:0009897]; inward rectifier potassium channel complex [GO:1902937]; membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]	GO:0005242; GO:0005886; GO:0008076; GO:0009897; GO:0015467; GO:0016020; GO:0030315; GO:0071805; GO:0086089; GO:0086091; GO:0098914; GO:1902937; GO:1990573
GN001062	GN001062.1	P48548	40.1	327	405	419	1.47e-83	264	KCNJ5_RAT	G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)	Rattus norvegicus (Rat)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]	external side of plasma membrane [GO:0009897]; inward rectifier potassium channel complex [GO:1902937]; membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]	GO:0005242; GO:0005886; GO:0008076; GO:0009897; GO:0015467; GO:0016020; GO:0030315; GO:0071805; GO:0086089; GO:0086091; GO:0098914; GO:1902937; GO:1990573
GN001063	GN001063.1	P48548	40.1	327	405	419	1.47e-83	264	KCNJ5_RAT	G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)	Rattus norvegicus (Rat)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]	external side of plasma membrane [GO:0009897]; inward rectifier potassium channel complex [GO:1902937]; membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]	GO:0005242; GO:0005886; GO:0008076; GO:0009897; GO:0015467; GO:0016020; GO:0030315; GO:0071805; GO:0086089; GO:0086091; GO:0098914; GO:1902937; GO:1990573
GN001064	GN001064.1	P48548	40.1	327	405	419	1.47e-83	264	KCNJ5_RAT	G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)	Rattus norvegicus (Rat)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]	external side of plasma membrane [GO:0009897]; inward rectifier potassium channel complex [GO:1902937]; membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]	GO:0005242; GO:0005886; GO:0008076; GO:0009897; GO:0015467; GO:0016020; GO:0030315; GO:0071805; GO:0086089; GO:0086091; GO:0098914; GO:1902937; GO:1990573
GN001066	GN001066.1	P48548	40.1	327	405	419	1.47e-83	264	KCNJ5_RAT	G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)	Rattus norvegicus (Rat)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]	external side of plasma membrane [GO:0009897]; inward rectifier potassium channel complex [GO:1902937]; membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]	GO:0005242; GO:0005886; GO:0008076; GO:0009897; GO:0015467; GO:0016020; GO:0030315; GO:0071805; GO:0086089; GO:0086091; GO:0098914; GO:1902937; GO:1990573
GN001072	GN001072.1	Q8R3V6	27.9	513	571	388	3.82e-23	105	CUED1_MOUSE	CUE domain-containing protein 1	Mus musculus (Mouse)		ubiquitin binding [GO:0043130]		GO:0043130
GN001073	GN001073.1	Q5F2F2	36.8	361	451	459	1.21e-62	213	ABH15_MOUSE	Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15)	Mus musculus (Mouse)	adipose tissue development [GO:0060612]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]	monoacylglycerol lipase activity [GO:0047372]; short-chain carboxylesterase activity [GO:0034338]	extracellular region [GO:0005576]	GO:0005576; GO:0006629; GO:0016042; GO:0034338; GO:0047372; GO:0060612
GN001074	GN001074.1	Q2TBR2	43.6	94	121	149	8.28e-17	74.3	RM20_BOVIN	Large ribosomal subunit protein bL20m (39S ribosomal protein L20, mitochondrial) (L20mt) (MRP-L20)	Bos taurus (Bovine)	translation [GO:0006412]	rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	large ribosomal subunit [GO:0015934]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005761; GO:0005762; GO:0006412; GO:0015934; GO:0019843
GN001075	GN001075.1	P52209	76.9	247	257	483	2.08e-133	388	6PGD_HUMAN	6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)	Homo sapiens (Human)	D-gluconate metabolic process [GO:0019521]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]	carbohydrate binding [GO:0030246]; carboxylic acid binding [GO:0031406]; NADP binding [GO:0050661]; phosphogluconate dehydrogenase (decarboxylating) activity [GO:0004616]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0004616; GO:0005634; GO:0005829; GO:0006098; GO:0009051; GO:0019521; GO:0030246; GO:0031406; GO:0050661; GO:0070062
GN001076	GN001076.1	Q9VZS7	53.7	123	134	2300	1.12e-40	147	HOBIT_DROME	Protein hobbit (Bridge-like lipid transfer protein family member 2) (BLTP2)	Drosophila melanogaster (Fruit fly)	positive regulation of regulated secretory pathway [GO:1903307]	phosphatidylinositol binding [GO:0035091]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	GO:0005783; GO:0005789; GO:0005886; GO:0031966; GO:0035091; GO:0140268; GO:1903307
GN001077	GN001077.1	Q9VZS7	36.5	367	357	2300	1.94e-49	181	HOBIT_DROME	Protein hobbit (Bridge-like lipid transfer protein family member 2) (BLTP2)	Drosophila melanogaster (Fruit fly)	positive regulation of regulated secretory pathway [GO:1903307]	phosphatidylinositol binding [GO:0035091]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	GO:0005783; GO:0005789; GO:0005886; GO:0031966; GO:0035091; GO:0140268; GO:1903307
GN001078	GN001078.1	Q14667	44.6	303	283	2235	1.11e-63	219	BLTP2_HUMAN	Bridge-like lipid transfer protein family member 2 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) (Protein hobbit homolog)	Homo sapiens (Human)		phosphatidylinositol binding [GO:0035091]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	GO:0005789; GO:0005886; GO:0031966; GO:0035091; GO:0140268
GN001079	GN001079.1	Q4KLI9	27.3	150	285	569	2.94e-12	70.1	FBXW5_RAT	F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)	Rattus norvegicus (Rat)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	protein kinase binding [GO:0019901]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005737; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0080008
GN001081	GN001081.1	Q969U6	22.9	532	456	566	1.64e-15	82.4	FBXW5_HUMAN	F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)	Homo sapiens (Human)	centrosome duplication [GO:0051298]; cilium assembly [GO:0060271]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	protein kinase binding [GO:0019901]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005737; GO:0005829; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0051298; GO:0060271; GO:0080008
GN001082	GN001082.1	F7H9X2	27.6	322	589	744	1.31e-28	124	TRIM2_CALJA	Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2)	Callithrix jacchus (White-tufted-ear marmoset) (Simia Jacchus)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0043161; GO:0043523; GO:0061630
GN001083	GN001083.1	Q18120	29.4	309	353	461	3.11e-26	112	TWK18_CAEEL	TWiK family of potassium channels protein 18	Caenorhabditis elegans	locomotion [GO:0040011]; muscle contraction [GO:0006936]; potassium ion transport [GO:0006813]	outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0006813; GO:0006936; GO:0015271; GO:0016020; GO:0022841; GO:0040011
GN001084	GN001084.1	Q2KHM9	25.8	1009	1006	967	1.91e-36	152	MOONR_HUMAN	Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein)	Homo sapiens (Human)	centriole replication [GO:0007099]; cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; protein localization to centrosome [GO:0071539]		centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; microtubule organizing center [GO:0005815]	GO:0005813; GO:0005814; GO:0005815; GO:0007099; GO:0034451; GO:0060271; GO:0061824; GO:0071539
GN001088	GN001088.1	Q967F4	28.4	183	243	2920	4.18e-13	72.0	HMR1_CAEEL	Cadherin-related hmr-1 (Protein Hammerhead)	Caenorhabditis elegans	apical constriction involved in gastrulation [GO:0003384]; axonogenesis [GO:0007409]; cell migration [GO:0016477]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion mediated by cadherin [GO:0044331]; cortical actin cytoskeleton organization [GO:0030866]; embryo development ending in birth or egg hatching [GO:0009792]; epithelial cell differentiation [GO:0030855]; establishment of mitotic spindle orientation [GO:0000132]; gastrulation [GO:0007369]; homophilic cell-cell adhesion [GO:0007156]	beta-catenin binding [GO:0008013]; calcium ion binding [GO:0005509]; delta-catenin binding [GO:0070097]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; catenin complex [GO:0016342]; distal dendrite [GO:0150002]; plasma membrane [GO:0005886]	GO:0000132; GO:0003384; GO:0005509; GO:0005886; GO:0005912; GO:0007156; GO:0007369; GO:0007409; GO:0008013; GO:0009792; GO:0016342; GO:0016477; GO:0030855; GO:0030866; GO:0042074; GO:0044331; GO:0070097; GO:0070161; GO:0150002
GN001090	GN001090.1	M9PH32	26.8	205	716	1206	1.62e-15	84.7	MEI26_DROME	Protein meiotic P26	Drosophila melanogaster (Fruit fly)	protein ubiquitination [GO:0016567]	ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]	GO:0004842; GO:0005737; GO:0008270; GO:0016567; GO:0036464
GN001091	GN001091.1	P19534	46.0	163	155	906	2.35e-33	127	CADH2_BOVIN	Cadherin-2 (Neural cadherin) (N-cadherin) (CD antigen CD325)	Bos taurus (Bovine)	adherens junction organization [GO:0034332]; calcium-dependent cell-cell adhesion [GO:0016339]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell junction assembly [GO:0007043]; glial cell differentiation [GO:0010001]; homophilic cell-cell adhesion [GO:0007156]; neural crest cell development [GO:0014032]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of axon extension [GO:0045773]; positive regulation of protein localization [GO:1903829]; synapse assembly [GO:0007416]; synaptic vesicle clustering [GO:0097091]; type B pancreatic cell development [GO:0003323]	beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; apical part of cell [GO:0045177]; axon [GO:0030424]; catenin complex [GO:0016342]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; sarcolemma [GO:0042383]	GO:0000902; GO:0003323; GO:0005509; GO:0005737; GO:0005886; GO:0005911; GO:0005912; GO:0007043; GO:0007156; GO:0007416; GO:0008013; GO:0009986; GO:0010001; GO:0014032; GO:0014704; GO:0016339; GO:0016342; GO:0016477; GO:0030027; GO:0030054; GO:0030057; GO:0030424; GO:0034332; GO:0042383; GO:0043005; GO:0044331; GO:0045177; GO:0045296; GO:0045773; GO:0070161; GO:0097091; GO:0097150; GO:0098609; GO:0098793; GO:1903829
GN001092	GN001092.1	Q9H6X4	39.2	102	187	195	1.01e-16	77.4	TM134_HUMAN	Transmembrane protein 134	Homo sapiens (Human)			cytosol [GO:0005829]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	GO:0005829; GO:0016020; GO:0048471
GN001095	GN001095.1	Q9UKP5	25.0	773	2165	1117	9.25e-37	156	ATS6_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAM-TS 6) (ADAM-TS6) (ADAMTS-6) (EC 3.4.24.-)	Homo sapiens (Human)	extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	extracellular matrix [GO:0031012]	GO:0004222; GO:0006508; GO:0008237; GO:0030198; GO:0031012
GN001098	GN001098.1	P48548	40.1	327	517	419	2.08e-82	265	KCNJ5_RAT	G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)	Rattus norvegicus (Rat)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]	external side of plasma membrane [GO:0009897]; inward rectifier potassium channel complex [GO:1902937]; membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]	GO:0005242; GO:0005886; GO:0008076; GO:0009897; GO:0015467; GO:0016020; GO:0030315; GO:0071805; GO:0086089; GO:0086091; GO:0098914; GO:1902937; GO:1990573
GN001099	GN001099.1	P48545	37.9	367	447	419	3.01e-82	262	KCNJ5_MOUSE	G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)	Mus musculus (Mouse)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]	external side of plasma membrane [GO:0009897]; inward rectifier potassium channel complex [GO:1902937]; membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]	GO:0005242; GO:0005886; GO:0008076; GO:0009897; GO:0015467; GO:0016020; GO:0030315; GO:0071805; GO:0086089; GO:0086091; GO:0098914; GO:1902937; GO:1990573
GN001100	GN001100.1	A6QQ71	31.5	308	484	326	2.92e-33	131	FKBP6_BOVIN	Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36)	Bos taurus (Bovine)	meiotic cell cycle [GO:0051321]; piRNA processing [GO:0034587]; protein folding [GO:0006457]; regulatory ncRNA-mediated gene silencing [GO:0031047]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]	Hsp90 protein binding [GO:0051879]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]	GO:0000795; GO:0005634; GO:0005737; GO:0005829; GO:0006457; GO:0007283; GO:0031047; GO:0034587; GO:0051321; GO:0051879; GO:0141196
GN001101	GN001101.1	Q13867	54.2	439	482	455	1.35e-180	516	BLMH_HUMAN	Bleomycin hydrolase (BH) (BLM hydrolase) (BMH) (EC 3.4.22.40)	Homo sapiens (Human)	L-homocysteine catabolic process [GO:0043418]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; response to toxic substance [GO:0009636]	aminopeptidase activity [GO:0004177]; carboxypeptidase activity [GO:0004180]; cysteine-type aminopeptidase activity [GO:0070005]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0000209; GO:0004177; GO:0004180; GO:0004197; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0008234; GO:0009636; GO:0042802; GO:0043418; GO:0070005; GO:0070062
GN001102	GN001102.1	Q8TCT0	31.3	192	224	537	1.90e-22	98.2	CERK1_HUMAN	Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4)	Homo sapiens (Human)	ceramide metabolic process [GO:0006672]; glycosphingolipid biosynthetic process [GO:0006688]	ceramide kinase activity [GO:0001729]; magnesium ion binding [GO:0000287]	cytoplasm [GO:0005737]; cytoplasmic side of trans-Golgi network membrane [GO:0160281]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0000287; GO:0001729; GO:0005737; GO:0005886; GO:0006672; GO:0006688; GO:0016020; GO:0160281
GN001103	GN001103.1	Q9Y2S7	33.4	317	320	368	1.73e-46	164	PDIP2_HUMAN	Polymerase delta-interacting protein 2 (38 kDa DNA polymerase delta interaction protein) (p38)	Homo sapiens (Human)	error-free translesion synthesis [GO:0070987]	DNA binding [GO:0003677]; protein-macromolecule adaptor activity [GO:0030674]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0005739; GO:0005759; GO:0030674; GO:0042645; GO:0070987
GN001109	GN001109.1	Q9D305	35.5	110	211	217	3.33e-10	60.8	THAP2_MOUSE	THAP domain-containing protein 2	Mus musculus (Mouse)			nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730
GN001114	GN001114.1	Q9WIJ5	37.5	128	252	286	8.00e-24	100	MREP_FBNY1	Master replication protein (M-Rep) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase C2) (Replication-associated protein 2) (Rep2)	Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV)	DNA replication [GO:0006260]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleotidyltransferase activity [GO:0016779]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	host cell nucleus [GO:0042025]	GO:0003677; GO:0003723; GO:0003724; GO:0004519; GO:0005524; GO:0006260; GO:0016779; GO:0016887; GO:0042025; GO:0046872
GN001115	GN001115.1	Q6ZU67	46.3	67	553	534	4.26e-09	62.8	BEND4_HUMAN	BEN domain-containing protein 4 (Coiled-coil domain-containing protein 4)	Homo sapiens (Human)		DNA binding [GO:0003677]		GO:0003677
GN001120	GN001120.1	Q6AZB8	40.4	166	206	349	2.56e-38	138	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN001132	GN001132.1	Q75QN2	34.4	1015	997	995	2.86e-165	514	INT8_HUMAN	Integrator complex subunit 8 (Int8) (Protein kaonashi-1)	Homo sapiens (Human)	protein localization to chromatin [GO:0071168]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; RNA polymerase II transcription initiation surveillance [GO:0160240]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]		chromatin [GO:0000785]; chromosome [GO:0005694]; INTAC complex [GO:0160232]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0005694; GO:0016180; GO:0032039; GO:0034243; GO:0034472; GO:0071168; GO:0160232; GO:0160240
GN001133	GN001133.1	Q80TB8	57.5	369	444	417	5.74e-153	443	VAT1L_MOUSE	Putative NADPH-dependent quinone oxidoreductase VAT1L (EC 1.6.5.5) (Synaptic vesicle membrane protein VAT-1 homolog-like) (Vesicle amine transport protein 1 like)	Mus musculus (Mouse)		NADPH dehydrogenase (quinone) activity [GO:0008753]; quinone reductase (NADPH) activity [GO:0003960]; zinc ion binding [GO:0008270]		GO:0003960; GO:0008270; GO:0008753
GN001134	GN001134.1	P22897	29.1	1287	1790	1456	2.98e-148	499	MRC1_HUMAN	Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206)	Homo sapiens (Human)	receptor-mediated endocytosis [GO:0006898]	cargo receptor activity [GO:0038024]; D-mannose binding [GO:0005537]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	GO:0004888; GO:0005537; GO:0005886; GO:0006898; GO:0009986; GO:0010008; GO:0038024
GN001135	GN001135.1	Q01414	71.9	178	262	173	9.85e-81	243	ERG_LYTVA	Transcriptional regulator ERG homolog	Lytechinus variegatus (Green sea urchin) (Echinus variegatus)	cell differentiation [GO:0030154]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0030154; GO:0043565
GN001137	GN001137.1	Q4ADK4	42.0	300	290	298	7.08e-47	162	CFDP1_MUNRE	Heterochromatin-stabilizing protein CFDP1 (Bucentaur) (Craniofacial development protein 1)	Muntiacus reevesi (Reeves' muntjac) (Cervus reevesi)			chromosome [GO:0005694]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]	GO:0000812; GO:0005634; GO:0005694
GN001140	GN001140.1	P22735	37.6	688	741	817	3.48e-143	442	TGM1_HUMAN	Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) [Cleaved into: Protein-glutamine gamma-glutamyltransferase K 67 kDa chain; Protein-glutamine gamma-glutamyltransferase K 33 kDa chain]	Homo sapiens (Human)	cell envelope organization [GO:0043163]; cornification [GO:0070268]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838]; protein modification process [GO:0036211]	identical protein binding [GO:0042802]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001533; GO:0003810; GO:0005829; GO:0005886; GO:0010838; GO:0016020; GO:0018149; GO:0030216; GO:0036211; GO:0042802; GO:0043163; GO:0045787; GO:0070062; GO:0070268
GN001141	GN001141.1	Q8BXA7	38.1	1066	1738	1320	1.99e-144	484	PHLP2_MOUSE	PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; protein dephosphorylation [GO:0006470]	protein serine/threonine phosphatase activity [GO:0004722]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment membrane [GO:0042622]	GO:0001917; GO:0004722; GO:0005634; GO:0005737; GO:0005829; GO:0005929; GO:0006470; GO:0035556; GO:0042622; GO:0045171; GO:0072686
GN001144	GN001144.1	Q8N2E2	22.4	809	886	1590	5.34e-28	125	VWDE_HUMAN	von Willebrand factor D and EGF domain-containing protein	Homo sapiens (Human)		signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]	GO:0005102; GO:0005576; GO:0009986
GN001145	GN001145.1	P17178	28.0	496	490	533	1.05e-53	192	CP27A_RAT	Sterol 26-hydroxylase, mitochondrial (EC 1.14.15.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase)	Rattus norvegicus (Rat)	bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; C21-steroid hormone biosynthetic process [GO:0006700]; calcitriol biosynthetic process from calciol [GO:0036378]; cholesterol catabolic process [GO:0006707]; cholesterol metabolic process [GO:0008203]; positive regulation of smoothened signaling pathway [GO:0045880]; steroid catabolic process [GO:0006706]	cholestanetetraol 26-dehydrogenase activity [GO:0047748]; cholesterol 26-hydroxylase activity [GO:0031073]; cholesterol 7-alpha-monooxygenase activity [GO:0008123]; cholesterol monooxygenase (side-chain-cleaving) activity [GO:0008386]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [GO:0016716]; vitamin D 25-hydroxylase activity [GO:0030343]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005506; GO:0005739; GO:0005743; GO:0006699; GO:0006700; GO:0006706; GO:0006707; GO:0008123; GO:0008203; GO:0008206; GO:0008386; GO:0016716; GO:0020037; GO:0030343; GO:0030544; GO:0031073; GO:0036378; GO:0045880; GO:0047748
GN001150	GN001150.1	P24862	40.5	257	637	408	1.25e-54	194	CCNB_PATVU	G2/mitotic-specific cyclin-B	Patella vulgata (Common limpet)	mitotic cell cycle phase transition [GO:0044772]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]		GO:0016538; GO:0044772
GN001151	GN001151.1	Q9D187	73.2	153	156	163	3.65e-75	224	CIA2B_MOUSE	Cytosolic iron-sulfur assembly component 2B (Mitotic spindle-associated MMXD complex subunit MIP18)	Mus musculus (Mouse)	chromosome segregation [GO:0007059]; protein maturation [GO:0051604]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic [4Fe-4S] assembly targeting complex [GO:0097361]; midbody [GO:0030496]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0005634; GO:0005654; GO:0005737; GO:0005819; GO:0005829; GO:0007059; GO:0030496; GO:0051604; GO:0071817; GO:0097361
GN001152	GN001152.1	A2RT91	25.0	747	863	1465	1.38e-61	231	ANKAR_MOUSE	Ankyrin and armadillo repeat-containing protein	Mus musculus (Mouse)			membrane [GO:0016020]	GO:0016020
GN001153	GN001153.1	P26599	33.7	175	300	557	1.63e-21	97.8	PTBP1_HUMAN	Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)	Homo sapiens (Human)	IRES-dependent viral translational initiation [GO:0075522]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of RNA splicing [GO:0033119]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of cell differentiation [GO:0045595]; RNA splicing [GO:0008380]	poly-pyrimidine tract binding [GO:0008187]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; P-body [GO:0000932]	GO:0000381; GO:0000932; GO:0003723; GO:0005654; GO:0005730; GO:0005737; GO:0006397; GO:0008187; GO:0008380; GO:0016020; GO:0033119; GO:0036002; GO:0045595; GO:0045665; GO:0048025; GO:0051148; GO:0070062; GO:0070886; GO:0075522
GN001154	GN001154.1	Q61140	26.5	1030	922	874	1.15e-68	249	BCAR1_MOUSE	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell receptor signaling pathway [GO:0050853]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to endothelin [GO:1990859]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to nitric oxide [GO:0071732]; endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; insulin receptor signaling pathway [GO:0008286]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell migration [GO:0010595]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; ruffle [GO:0001726]	GO:0001726; GO:0005737; GO:0005829; GO:0005925; GO:0007015; GO:0007169; GO:0007173; GO:0007186; GO:0007229; GO:0008286; GO:0010595; GO:0015629; GO:0016020; GO:0016477; GO:0019901; GO:0019904; GO:0030027; GO:0030036; GO:0030335; GO:0030424; GO:0035729; GO:0048008; GO:0048010; GO:0048011; GO:0048012; GO:0050851; GO:0050853; GO:0060326; GO:0071732; GO:0086100; GO:1900025; GO:1990859
GN001155	GN001155.1	F1QG30	29.1	539	462	545	9.13e-57	199	NSMA5_DANRE	Sphingomyelin phosphodiesterase 5 (EC 3.1.4.12) (Mitochondrial neutral sphingomyelinase) (mtnSMase)	Danio rerio (Zebrafish) (Brachydanio rerio)	ceramide biosynthetic process [GO:0046513]; glycosphingolipid metabolic process [GO:0006687]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684]	glycerophospholipase activity [GO:0004620]; sphingomyelin phosphodiesterase activity [GO:0004767]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]	GO:0004620; GO:0004767; GO:0005576; GO:0005737; GO:0005743; GO:0005758; GO:0005789; GO:0006684; GO:0006685; GO:0006687; GO:0031966; GO:0046513
GN001159	GN001159.1	Q8WY91	38.0	108	216	577	3.09e-11	65.5	THAP4_HUMAN	Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4)	Homo sapiens (Human)	cellular response to reactive nitrogen species [GO:1902170]	heme binding [GO:0020037]; identical protein binding [GO:0042802]; nitric oxide binding [GO:0070026]; peroxynitrite isomerase activity [GO:0062213]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005829; GO:0020037; GO:0042802; GO:0062213; GO:0070026; GO:1902170
GN001167	GN001167.1	P86860	33.9	271	2015	294	2.57e-41	158	PSM_MYTCA	Shell matrix protein	Mytilus californianus (California mussel)			extracellular region [GO:0005576]	GO:0005576
GN001171	GN001171.1	A5YVV0	27.8	826	1139	661	2.98e-95	321	LAC3_ANOGA	Multicopper oxidase 3 (AgMCO3) (EC 1.10.3.2) (Laccase-3)	Anopheles gambiae (African malaria mosquito)		copper ion binding [GO:0005507]; hydroquinone:oxygen oxidoreductase activity [GO:0052716]	extracellular region [GO:0005576]	GO:0005507; GO:0005576; GO:0052716
GN001175	GN001175.1	P47743	41.2	588	624	908	1.82e-140	434	GRM8_MOUSE	Metabotropic glutamate receptor 8 (mGluR8)	Mus musculus (Mouse)	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic transmission, glutamatergic [GO:0035249]	G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]	GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; presynaptic membrane [GO:0042734]	GO:0001642; GO:0004930; GO:0005886; GO:0007193; GO:0007196; GO:0007216; GO:0007268; GO:0008066; GO:0035249; GO:0042734; GO:0043025; GO:0046928; GO:0048787; GO:0050966; GO:0051966; GO:0098978; GO:0098982; GO:0099171
GN001176	GN001176.1	P91685	47.6	82	134	976	1.81e-18	83.6	GRM_DROME	Metabotropic glutamate receptor (DmGluRA)	Drosophila melanogaster (Fruit fly)	G protein-coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; long-term memory [GO:0007616]; male courtship behavior [GO:0008049]; neuromuscular junction development [GO:0007528]; regulation of synaptic transmission, glutamatergic [GO:0051966]; short-term memory [GO:0007614]; terminal button organization [GO:0072553]	cholesterol binding [GO:0015485]; G protein-coupled receptor activity [GO:0004930]; glutamate binding [GO:0016595]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]	G protein-coupled receptor homodimeric complex [GO:0038038]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0001641; GO:0004930; GO:0005886; GO:0007216; GO:0007528; GO:0007612; GO:0007614; GO:0007616; GO:0008049; GO:0008066; GO:0015485; GO:0016020; GO:0016595; GO:0038038; GO:0045121; GO:0051966; GO:0072553
GN001177	GN001177.1	Q8BN57	27.9	147	195	294	4.00e-16	77.8	MISO1_MOUSE	Mitochondrial inner membrane subdomain organizer 1	Mus musculus (Mouse)	negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of mitochondrial fusion [GO:0010637]; positive regulation of mitochondrial fission [GO:0090141]		extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]	GO:0005576; GO:0005743; GO:0010637; GO:0070373; GO:0090141
GN001186	GN001186.1	A1A4J8	52.5	202	273	305	4.49e-75	234	SCO1_BOVIN	Cytochrome c oxidase assembly factor SCO1	Bos taurus (Bovine)	mitochondrial respiratory chain complex IV assembly [GO:0033617]		mitochondrial inner membrane [GO:0005743]	GO:0005743; GO:0033617
GN001187	GN001187.1	A1BQQ5	37.1	275	300	289	4.15e-53	178	MR30_CONMR	Cysteine-rich venom protein Mr30 (CRVP) (Cysteine-rich secretory protein Mr30) (GlaCrisp form 1/2/3) (Mr30-1/2)	Conus marmoreus (Marble cone)			extracellular region [GO:0005576]	GO:0005576
GN001188	GN001188.1	Q7YT83	37.8	286	427	300	7.50e-55	187	TX31_CONTE	Cysteine-rich venom protein (CRVP) (EC 3.4.-.-) (Substrate-specific endoprotease Tex31)	Conus textile (Cloth-of-gold cone)			extracellular region [GO:0005576]	GO:0005576
GN001191	GN001191.1	Q28F51	54.7	371	457	409	3.95e-129	382	TADBP_XENTR	TAR DNA-binding protein 43 (TDP-43)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of protein stability [GO:0031647]; RNA splicing [GO:0008380]	double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0003690; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0008380; GO:0010468; GO:0010494; GO:0031647; GO:0042752
GN001195	GN001195.1	Q90Z12	56.0	84	361	281	1.10e-21	96.7	HES4A_XENLA	Transcription factor HES-4-A (Hairy and enhancer of split 4-A) (Protein hairy-2) (Xhairy2) (Protein hairy-2a) (Xhairy2a)	Xenopus laevis (African clawed frog)	anterior/posterior pattern specification [GO:0009952]; BMP signaling pathway [GO:0030509]; floor plate development [GO:0033504]; lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest formation [GO:0014029]; prechordal plate formation [GO:0021501]; regulation of neurogenesis [GO:0050767]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0002088; GO:0005634; GO:0009952; GO:0014029; GO:0021501; GO:0030509; GO:0033504; GO:0043066; GO:0043425; GO:0043565; GO:0045892; GO:0046983; GO:0050767
GN001196	GN001196.1	Q9WVR6	54.4	241	242	533	1.77e-80	253	LAT2_RAT	Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (Solute carrier family 7 member 8)	Rattus norvegicus (Rat)	amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine import across plasma membrane [GO:1904273]; L-amino acid transport [GO:0015807]; L-leucine import across plasma membrane [GO:1903801]; L-leucine transport [GO:0015820]; neutral amino acid transport [GO:0015804]; proline transmembrane transport [GO:0035524]; thyroid hormone transport [GO:0070327]; tryptophan transport [GO:0015827]; valine transport [GO:0015829]	amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-amino acid transmembrane transporter activity [GO:0015179]; L-leucine transmembrane transporter activity [GO:0015190]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; protein heterodimerization activity [GO:0046982]; thyroid hormone transmembrane transporter activity [GO:0015349]; toxin transmembrane transporter activity [GO:0019534]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]	GO:0003333; GO:0005886; GO:0006865; GO:0009925; GO:0015171; GO:0015175; GO:0015179; GO:0015180; GO:0015187; GO:0015190; GO:0015297; GO:0015349; GO:0015804; GO:0015807; GO:0015816; GO:0015820; GO:0015827; GO:0015829; GO:0016323; GO:0016324; GO:0019534; GO:0022857; GO:0031528; GO:0035524; GO:0042605; GO:0046982; GO:0070327; GO:0089718; GO:1902495; GO:1903801; GO:1904273
GN001197	GN001197.1	P50729	39.5	76	114	496	4.92e-10	58.5	RECS_BACSU	Probable ATP-dependent DNA helicase RecS (EC 5.6.2.4) (Probable DNA 3'-5' helicase RecS) (Recombination protein S)	Bacillus subtilis (strain 168)	DNA recombination [GO:0006310]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]	GO:0003676; GO:0005524; GO:0005694; GO:0005737; GO:0006310; GO:0016887; GO:0030894; GO:0043138; GO:0043590
GN001198	GN001198.1	Q3UMM4	76.5	183	205	360	1.23e-94	283	CDK10_MOUSE	Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10)	Mus musculus (Mouse)	G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of cilium assembly [GO:1902018]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of MAPK cascade [GO:0043410]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of mitotic cell cycle [GO:0007346]	ATP binding [GO:0005524]; cyclin-dependent protein kinase activity [GO:0097472]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ciliary basal body [GO:0036064]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nucleus [GO:0005634]	GO:0000086; GO:0000307; GO:0004674; GO:0004693; GO:0005524; GO:0005634; GO:0007346; GO:0018107; GO:0032956; GO:0036064; GO:0043410; GO:0097472; GO:0106310; GO:1902018; GO:1902749
GN001199	GN001199.1	Q95L73	51.7	116	152	191	2.41e-25	98.6	CY24A_BISBI	Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox)	Bison bison (American bison) (Bos bison)	innate immune response [GO:0045087]	heme binding [GO:0020037]	NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]	GO:0005886; GO:0020037; GO:0043020; GO:0045087
GN001206	GN001206.1	F4JTS8	24.8	2304	3103	2729	2.45e-135	481	NOV_ARATH	Protein NO VEIN (Protein EMBRYO DEFECTIVE 2597)	Arabidopsis thaliana (Mouse-ear cress)	auxin polar transport [GO:0009926]; cell fate specification [GO:0001708]; embryo development ending in seed dormancy [GO:0009793]; leaf vascular tissue pattern formation [GO:0010305]; root development [GO:0048364]; stem cell population maintenance [GO:0019827]		nucleus [GO:0005634]	GO:0001708; GO:0005634; GO:0009793; GO:0009926; GO:0010305; GO:0019827; GO:0048364
GN001210	GN001210.1	Q9HCC6	50.9	114	1570	221	4.37e-25	108	HES4_HUMAN	Transcription factor HES-4 (hHES4) (Class B basic helix-loop-helix protein 42) (bHLHb42) (Hairy and enhancer of split 4) (bHLH factor Hes4)	Homo sapiens (Human)	anterior/posterior pattern specification [GO:0009952]; negative regulation of transcription by RNA polymerase II [GO:0000122]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000978; GO:0000981; GO:0005634; GO:0009952; GO:0046983
GN001211	GN001211.1	Q70J99	25.4	968	1084	1090	9.74e-52	202	UN13D_HUMAN	Protein unc-13 homolog D (Munc13-4)	Homo sapiens (Human)	platelet dense granule organization [GO:0060155]; positive regulation of exocytosis [GO:0045921]; positive regulation of regulated secretory pathway [GO:1903307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of mast cell degranulation [GO:0043304]; secretion [GO:0046903]; vasculature development [GO:0001944]	small GTPase binding [GO:0031267]	azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; exocytic vesicle [GO:0070382]; extracellular region [GO:0005576]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; recycling endosome [GO:0055037]; Weibel-Palade body [GO:0033093]	GO:0001944; GO:0005576; GO:0005764; GO:0005770; GO:0005829; GO:0016020; GO:0031267; GO:0033093; GO:0035578; GO:0043304; GO:0045921; GO:0046903; GO:0055037; GO:0060155; GO:0070382; GO:1900026; GO:1903307
GN001212	GN001212.1	Q9VZU4	62.7	249	268	265	3.88e-108	316	NDUS3_DROME	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC 7.1.1.2) (NADH dehydrogenase (Ubiquinone) 30 kDa subunit)	Drosophila melanogaster (Fruit fly)	mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; reactive oxygen species metabolic process [GO:0072593]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271]	GO:0005739; GO:0005743; GO:0006120; GO:0008137; GO:0045271; GO:0072593
GN001213	GN001213.1	Q9Z2P6	31.7	259	240	257	2.56e-23	97.8	SNP29_RAT	Synaptosomal-associated protein 29 (SNAP-29) (Golgi SNARE of 32 kDa) (Gs32) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29)	Rattus norvegicus (Rat)	autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; cilium assembly [GO:0060271]; exocytosis [GO:0006887]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]	SNAP receptor activity [GO:0005484]; syntaxin binding [GO:0019905]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; ciliary pocket membrane [GO:0020018]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195]	GO:0000139; GO:0000421; GO:0005484; GO:0005737; GO:0005776; GO:0005829; GO:0006887; GO:0008021; GO:0016082; GO:0016240; GO:0019905; GO:0020018; GO:0031201; GO:0031629; GO:0043195; GO:0060271; GO:0097352; GO:0098693; GO:0098850; GO:2000300
GN001214	GN001214.1	O43614	26.1	357	398	444	5.48e-20	94.7	OX2R_HUMAN	Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2)	Homo sapiens (Human)	cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; glucose homeostasis [GO:0042593]; locomotion [GO:0040011]; neuropeptide signaling pathway [GO:0007218]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]	neuropeptide receptor activity [GO:0008188]; orexin receptor activity [GO:0016499]; peptide hormone binding [GO:0017046]	plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0005886; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0040011; GO:0042593; GO:0045202; GO:0051480
GN001218	GN001218.1	Q6NT55	40.8	476	520	531	8.32e-121	368	CP4FN_HUMAN	Ultra-long-chain fatty acid omega-hydroxylase (EC 1.14.14.177) (Cytochrome P450 4F22)	Homo sapiens (Human)	ceramide biosynthetic process [GO:0046513]; icosanoid metabolic process [GO:0006690]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	endoplasmic reticulum membrane [GO:0005789]	GO:0004497; GO:0005506; GO:0005789; GO:0006690; GO:0016705; GO:0020037; GO:0046513
GN001219	GN001219.1	P78329	43.4	433	438	520	1.41e-113	346	CP4F2_HUMAN	Cytochrome P450 4F2 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450-LTB-omega) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.14.94) (Phylloquinone omega-hydroxylase CYP4F2) (EC 1.14.14.78)	Homo sapiens (Human)	arachidonate metabolic process [GO:0019369]; blood coagulation [GO:0007596]; epoxygenase P450 pathway [GO:0019373]; fatty acid omega-oxidation [GO:0010430]; icosanoid metabolic process [GO:0006690]; leukotriene B4 catabolic process [GO:0036101]; leukotriene metabolic process [GO:0006691]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; negative regulation of icosanoid secretion [GO:0032304]; omega-hydroxylase P450 pathway [GO:0097267]; phylloquinone catabolic process [GO:0042376]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; regulation of blood pressure [GO:0008217]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; vitamin K catabolic process [GO:0042377]; xenobiotic metabolic process [GO:0006805]	20-aldehyde-leukotriene B4 20-monooxygenase activity [GO:0097259]; 20-hydroxy-leukotriene B4 omega oxidase activity [GO:0097258]; alkane 1-monooxygenase activity [GO:0018685]; alpha-tocopherol omega-hydroxylase activity [GO:0052871]; arachidonate epoxygenase activity [GO:0008392]; arachidonate omega-hydroxylase activity [GO:0052869]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; very long-chain fatty acid omega-hydroxylase activity [GO:0140692]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	GO:0000038; GO:0001676; GO:0003091; GO:0003095; GO:0004497; GO:0005506; GO:0005737; GO:0005789; GO:0006690; GO:0006691; GO:0006805; GO:0007596; GO:0008217; GO:0008392; GO:0010430; GO:0016324; GO:0016709; GO:0016712; GO:0018685; GO:0019369; GO:0019373; GO:0020037; GO:0032304; GO:0032305; GO:0036101; GO:0042360; GO:0042361; GO:0042376; GO:0042377; GO:0043231; GO:0050051; GO:0052869; GO:0052871; GO:0055078; GO:0097258; GO:0097259; GO:0097267; GO:0102033; GO:0140692
GN001220	GN001220.1	Q9BUN5	59.0	61	121	200	7.29e-19	80.9	CC28B_HUMAN	Coiled-coil domain-containing protein 28B	Homo sapiens (Human)	cilium assembly [GO:0060271]		centrosome [GO:0005813]	GO:0005813; GO:0060271
GN001222	GN001222.1	Q0VC50	45.2	62	105	396	4.41e-12	63.9	RT4I1_BOVIN	NAD(P)H oxidoreductase RTN4IP1, mitochondrial (EC 1.6.5.-) (Reticulon-4-interacting protein 1)	Bos taurus (Bovine)	regulation of dendrite development [GO:0050773]; ubiquinone biosynthetic process [GO:0006744]	NADH dehydrogenase (quinone) (non-electrogenic) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0005739; GO:0005741; GO:0005759; GO:0006744; GO:0008270; GO:0008753; GO:0050136; GO:0050773
GN001223	GN001223.1	Q6GLJ1	28.0	243	504	470	3.35e-28	120	BTBDH_XENLA	BTB/POZ domain-containing protein 17	Xenopus laevis (African clawed frog)			extracellular region [GO:0005576]	GO:0005576
GN001224	GN001224.1	Q6DE14	53.1	390	381	375	1.20e-107	323	E2F4_XENLA	Transcription factor E2F4 (E2F-4)	Xenopus laevis (African clawed frog)	centriole assembly [GO:0098534]; motile cilium assembly [GO:0044458]; multi-ciliated epithelial cell differentiation [GO:1903251]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000978; GO:0000981; GO:0003700; GO:0005634; GO:0006357; GO:0044458; GO:0045944; GO:0046983; GO:0090575; GO:0098534; GO:1903251
GN001225	GN001225.1	P07686	45.4	449	992	556	1.79e-132	414	HEXB_HUMAN	Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]	Homo sapiens (Human)	astrocyte cell migration [GO:0043615]; carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan catabolic process [GO:0030207]; dermatan sulfate proteoglycan catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; N-acetylglucosamine metabolic process [GO:0006044]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell shape [GO:0008360]; single fertilization [GO:0007338]	acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylglucosaminidase activity [GO:0016231]; beta-N-acetylhexosaminidase activity [GO:0004563]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; beta-N-acetylhexosaminidase complex [GO:1905379]; cortical granule [GO:0060473]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]	GO:0001669; GO:0004563; GO:0005576; GO:0005764; GO:0005975; GO:0006044; GO:0006689; GO:0007338; GO:0008360; GO:0008375; GO:0016020; GO:0016231; GO:0030203; GO:0030207; GO:0030209; GO:0030214; GO:0030246; GO:0035578; GO:0042582; GO:0042802; GO:0043202; GO:0043615; GO:0044877; GO:0045944; GO:0060473; GO:0070062; GO:1905379
GN001226	GN001226.1	Q969N2	45.6	511	569	578	4.45e-152	451	PIGT_HUMAN	GPI-anchor transamidase component PIGT (Phosphatidylinositol-glycan biosynthesis class T protein)	Homo sapiens (Human)	attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; GPI anchored protein biosynthesis [GO:0180046]	GPI anchor binding [GO:0034235]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]	GO:0005789; GO:0006506; GO:0016020; GO:0016255; GO:0031410; GO:0034235; GO:0042765; GO:0180046
GN001227	GN001227.1	Q5RDE7	72.6	402	370	457	1.68e-212	592	NFS1_PONAB	Cysteine desulfurase (EC 2.8.1.7)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	[2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]	cysteine desulfurase activity [GO:0031071]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]	centrosome [GO:0005813]; cytosol [GO:0005829]; mitochondrial [2Fe-2S] assembly complex [GO:0099128]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005739; GO:0005813; GO:0005829; GO:0030170; GO:0031071; GO:0042803; GO:0044571; GO:0044572; GO:0099128
GN001228	GN001228.1	P03957	36.1	330	374	475	6.68e-41	153	MMP3_RAT	Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (PTR1 protein) (Transin-1)	Rattus norvegicus (Rat)	cellular response to amino acid stimulus [GO:0071230]; cellular response to cell-matrix adhesion [GO:0071460]; cellular response to interleukin-1 [GO:0071347]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV-A [GO:0071492]; collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; female pregnancy [GO:0007565]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of cell migration [GO:0030335]; positive regulation of protein-containing complex assembly [GO:0031334]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of cell migration [GO:0030334]; response to amino acid [GO:0043200]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to tumor necrosis factor [GO:0034612]	endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; protein-containing complex binding [GO:0044877]; zinc ion binding [GO:0008270]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0001666; GO:0004175; GO:0004222; GO:0005576; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0006508; GO:0007565; GO:0008233; GO:0008237; GO:0008270; GO:0009612; GO:0030163; GO:0030198; GO:0030334; GO:0030335; GO:0030425; GO:0030574; GO:0031012; GO:0031334; GO:0032355; GO:0032496; GO:0032991; GO:0034097; GO:0034612; GO:0034614; GO:0043200; GO:0044297; GO:0044877; GO:0051898; GO:0070555; GO:0071230; GO:0071347; GO:0071460; GO:0071492; GO:2000378
GN001229	GN001229.1	Q2TA16	47.3	463	501	498	1.22e-129	389	DRC2_BOVIN	Dynein regulatory complex subunit 2 (Coiled-coil domain-containing protein 65)	Bos taurus (Bovine)	axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285]; regulation of cilium movement [GO:0003352]		axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514]	GO:0003352; GO:0005858; GO:0005930; GO:0031514; GO:0036064; GO:0060285; GO:0070286
GN001230	GN001230.1	Q96EQ9	36.9	141	338	843	4.41e-21	97.8	PRDM9_MOUSE	Histone-lysine N-methyltransferase PRDM9 (Hybrid sterility protein 1) (Meiosis-induced factor containing a PR/SET domain and zinc-finger motif) (PR domain zinc finger protein 9) (PR domain-containing protein 9) (Protein-lysine N-methyltransferase PRDM9) (EC 2.1.1.-) ([histone H3]-lysine36 N-trimethyltransferase PRDM9) (EC 2.1.1.359) ([histone H3]-lysine4 N-trimethyltransferase PRDM9) (EC 2.1.1.354) ([histone H3]-lysine9 N-trimethyltransferase PRDM9) (EC 2.1.1.355) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.361)	Mus musculus (Mouse)	double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; male gamete generation [GO:0048232]; meiotic gene conversion [GO:0006311]; negative regulation of apoptotic process [GO:0043066]; positive regulation of fertilization [GO:1905516]; positive regulation of meiosis I [GO:0060903]; positive regulation of reciprocal meiotic recombination [GO:0010845]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283]	histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; protein homodimerization activity [GO:0042803]; protein-lysine N-methyltransferase activity [GO:0016279]; recombination hotspot binding [GO:0010844]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000976; GO:0005634; GO:0005654; GO:0005694; GO:0006311; GO:0007129; GO:0007283; GO:0007292; GO:0008270; GO:0010468; GO:0010844; GO:0010845; GO:0016279; GO:0042800; GO:0042803; GO:0043066; GO:0043565; GO:0045944; GO:0046975; GO:0048232; GO:0060903; GO:0140941; GO:0140944; GO:0140949; GO:0140955; GO:0140999; GO:1905516; GO:1990918
GN001231	GN001231.1	Q03041	39.1	266	355	663	6.48e-50	180	CNGA2_BOVIN	Cyclic nucleotide-gated channel alpha-2 (CNG channel alpha-2) (CNG-2) (CNG2) (Cyclic nucleotide-gated channel alpha 3) (CNCalpha3) (CNGa3) (Olfactory cyclic nucleotide-gated channel subunit 1) (OCNC1)	Bos taurus (Bovine)	calcium ion transport [GO:0006816]; monoatomic cation transmembrane transport [GO:0098655]; potassium ion transport [GO:0006813]; response to hydrogen sulfide [GO:1904880]; sensory perception of chemical stimulus [GO:0007606]; sensory perception of smell [GO:0007608]; sodium ion transport [GO:0006814]	cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; monoatomic ion channel activity [GO:0005216]	intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; non-motile cilium membrane [GO:0098804]; plasma membrane [GO:0005886]	GO:0005216; GO:0005222; GO:0005223; GO:0005886; GO:0006813; GO:0006814; GO:0006816; GO:0007606; GO:0007608; GO:0017071; GO:0030553; GO:0098655; GO:0098804; GO:1904880
GN001236	GN001236.1	Q05858	27.9	419	1618	1213	1.97e-36	154	FMN_CHICK	Formin (Limb deformity protein)	Gallus gallus (Chicken)	actin nucleation [GO:0045010]; formin-nucleated actin cable assembly [GO:0070649]	actin binding [GO:0003779]; microtubule binding [GO:0008017]	actin filament [GO:0005884]; endoplasmic reticulum membrane [GO:0005789]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]	GO:0003779; GO:0005634; GO:0005789; GO:0005884; GO:0008017; GO:0015630; GO:0045010; GO:0070649
GN001237	GN001237.1	O16374	28.8	125	298	425	5.54e-11	66.2	GALT1_CAEEL	Beta-1,4-galactosyltransferase galt-1 (EC 2.4.1.-)	Caenorhabditis elegans	carbohydrate derivative biosynthetic process [GO:1901137]; N-glycan processing [GO:0006491]	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; UDP-galactosyltransferase activity [GO:0035250]	Golgi cisterna membrane [GO:0032580]	GO:0003831; GO:0006491; GO:0032580; GO:0035250; GO:1901137
GN001242	GN001242.1	E7FAM4	32.5	271	341	524	3.74e-36	140	G161A_DANRE	G protein-coupled receptor 161B	Danio rerio (Zebrafish) (Brachydanio rerio)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; negative regulation of smoothened signaling pathway [GO:0045879]	G protein-coupled receptor activity [GO:0004930]; signaling adaptor activity [GO:0035591]	non-motile cilium membrane [GO:0098804]; recycling endosome [GO:0055037]	GO:0004930; GO:0007189; GO:0035591; GO:0045879; GO:0055037; GO:0098804
GN001244	GN001244.1	Q3SZD7	55.7	271	281	277	2.77e-102	302	CBR1_BOVIN	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)	Bos taurus (Bovine)	vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH dehydrogenase (quinone) activity [GO:0008753]; prostaglandin E2 9-reductase activity [GO:0050221]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163]	cytoplasm [GO:0005737]	GO:0004090; GO:0005737; GO:0006805; GO:0008106; GO:0008753; GO:0042373; GO:0047020; GO:0047021; GO:0050221; GO:0160163
GN001245	GN001245.1	P47727	51.5	167	173	277	6.09e-57	182	CBR1_RAT	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)	Rattus norvegicus (Rat)	epithelial cell differentiation [GO:0030855]; glucocorticoid metabolic process [GO:0008211]; ovulation from ovarian follicle [GO:0001542]; phylloquinone catabolic process [GO:0042376]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; prostaglandin catabolic process [GO:1905344]; response to estradiol [GO:0032355]; response to gonadotropin [GO:0034698]; response to lipopolysaccharide [GO:0032496]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; steroid catabolic process [GO:0006706]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH dehydrogenase (quinone) activity [GO:0008753]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E2 9-reductase activity [GO:0050221]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microvillus [GO:0005902]	GO:0001542; GO:0004090; GO:0005737; GO:0005829; GO:0005902; GO:0006706; GO:0006805; GO:0008106; GO:0008211; GO:0008753; GO:0016616; GO:0016655; GO:0030855; GO:0032355; GO:0032496; GO:0032570; GO:0033574; GO:0034698; GO:0042373; GO:0042376; GO:0047020; GO:0047021; GO:0050221; GO:0160163; GO:1905344; GO:2000379
GN001246	GN001246.1	P47727	51.5	167	173	277	6.09e-57	182	CBR1_RAT	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)	Rattus norvegicus (Rat)	epithelial cell differentiation [GO:0030855]; glucocorticoid metabolic process [GO:0008211]; ovulation from ovarian follicle [GO:0001542]; phylloquinone catabolic process [GO:0042376]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; prostaglandin catabolic process [GO:1905344]; response to estradiol [GO:0032355]; response to gonadotropin [GO:0034698]; response to lipopolysaccharide [GO:0032496]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; steroid catabolic process [GO:0006706]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH dehydrogenase (quinone) activity [GO:0008753]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E2 9-reductase activity [GO:0050221]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microvillus [GO:0005902]	GO:0001542; GO:0004090; GO:0005737; GO:0005829; GO:0005902; GO:0006706; GO:0006805; GO:0008106; GO:0008211; GO:0008753; GO:0016616; GO:0016655; GO:0030855; GO:0032355; GO:0032496; GO:0032570; GO:0033574; GO:0034698; GO:0042373; GO:0042376; GO:0047020; GO:0047021; GO:0050221; GO:0160163; GO:1905344; GO:2000379
GN001247	GN001247.1	P0AFQ9	29.5	210	638	265	2.20e-12	71.2	YCFH_ECO57	Uncharacterized metal-dependent hydrolase YcfH (EC 3.1.-.-)	Escherichia coli O157:H7		DNA nuclease activity [GO:0004536]; hydrolase activity, acting on ester bonds [GO:0016788]	cytosol [GO:0005829]	GO:0004536; GO:0005829; GO:0016788
GN001249	GN001249.1	G5EFC3	29.1	447	455	558	5.21e-55	195	KCNAG_CAEEL	Potassium voltage-gated channel protein egl-36 (Egg-laying defective protein 36)	Caenorhabditis elegans	action potential [GO:0001508]; monoatomic ion transmembrane transport [GO:0034220]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic ion channel activity [GO:0005244]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005244; GO:0005251; GO:0008076; GO:0016020; GO:0032590; GO:0032809; GO:0034220; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN001250	GN001250.1	Q3SZD7	54.7	274	276	277	1.05e-105	311	CBR1_BOVIN	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)	Bos taurus (Bovine)	vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH dehydrogenase (quinone) activity [GO:0008753]; prostaglandin E2 9-reductase activity [GO:0050221]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163]	cytoplasm [GO:0005737]	GO:0004090; GO:0005737; GO:0006805; GO:0008106; GO:0008753; GO:0042373; GO:0047020; GO:0047021; GO:0050221; GO:0160163
GN001255	GN001255.1	Q3U145	44.3	228	348	381	4.79e-52	179	TMM64_MOUSE	Transmembrane protein 64	Mus musculus (Mouse)	negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of bone resorption [GO:0045780]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of osteoclast differentiation [GO:0045672]; regulation of ATP-dependent activity [GO:0043462]; regulation of cytosolic calcium ion concentration [GO:0051480]		endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	GO:0005783; GO:0016020; GO:0043462; GO:0045600; GO:0045668; GO:0045672; GO:0045780; GO:0051480; GO:0090090
GN001256	GN001256.1	P67827	93.6	282	323	325	3.82e-195	541	KC1A_BOVIN	Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1)	Bos taurus (Bovine)	intermediate filament cytoskeleton organization [GO:0045104]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; nuclear speck [GO:0016607]; spindle [GO:0005819]	GO:0000139; GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005813; GO:0005819; GO:0006468; GO:0016607; GO:0018105; GO:0036064; GO:0045104; GO:0090090; GO:0106310; GO:1900226
GN001259	GN001259.1	Q28DH9	56.9	547	545	661	9.81e-233	659	CEP76_XENTR	Centrosomal protein of 76 kDa (Cep76)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	regulation of centriole replication [GO:0046599]		centriole [GO:0005814]; centrosome [GO:0005813]	GO:0005813; GO:0005814; GO:0046599
GN001260	GN001260.1	Q5UR67	30.8	146	352	170	2.77e-10	62.0	RIBX_MIMIV	N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase)	Acanthamoeba polyphaga mimivirus (APMV)		hydrolase activity, acting on glycosyl bonds [GO:0016798]		GO:0016798
GN001261	GN001261.1	Q9HCD5	32.2	379	697	579	9.16e-31	131	NCOA5_HUMAN	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of signal transduction [GO:0009966]	chromatin binding [GO:0003682]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]	actin cytoskeleton [GO:0015629]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]	GO:0000122; GO:0003682; GO:0003714; GO:0003723; GO:0005576; GO:0005654; GO:0009966; GO:0015629
GN001263	GN001263.1	Q0P5G1	39.6	328	386	1374	1.52e-58	209	TONSL_BOVIN	Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)	Bos taurus (Bovine)	double-strand break repair via homologous recombination [GO:0000724]; replication fork processing [GO:0031297]	histone binding [GO:0042393]; histone reader activity [GO:0140566]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear replication fork [GO:0043596]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000724; GO:0005634; GO:0005694; GO:0005737; GO:0031297; GO:0035861; GO:0042393; GO:0043596; GO:0140566
GN001264	GN001264.1	A9JR78	34.2	120	161	1427	6.65e-10	60.1	TONSL_DANRE	Tonsoku-like protein (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	double-strand break repair via homologous recombination [GO:0000724]; replication fork processing [GO:0031297]	histone binding [GO:0042393]; histone reader activity [GO:0140566]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear replication fork [GO:0043596]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000724; GO:0005634; GO:0005694; GO:0005737; GO:0031297; GO:0035861; GO:0042393; GO:0043596; GO:0140566
GN001267	GN001267.1	Q9ET77	54.0	433	791	744	7.61e-76	264	JPH3_MOUSE	Junctophilin-3 (JP-3) (Junctophilin type 3)	Mus musculus (Mouse)	exploration behavior [GO:0035640]; learning [GO:0007612]; locomotion [GO:0040011]; memory [GO:0007613]; neuromuscular process controlling balance [GO:0050885]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of synaptic plasticity [GO:0048167]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005783; GO:0005789; GO:0005886; GO:0007612; GO:0007613; GO:0016020; GO:0030314; GO:0035640; GO:0040011; GO:0048167; GO:0048168; GO:0050885; GO:0060314
GN001272	GN001272.1	A7MBH3	41.3	75	215	327	9.32e-09	57.8	NAIF1_BOVIN	Nuclear apoptosis-inducing factor 1	Bos taurus (Bovine)	negative regulation of cell growth [GO:0030308]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0030308; GO:1902108
GN001277	GN001277.1	Q9H0W7	36.5	85	261	228	9.84e-12	66.2	THAP2_HUMAN	THAP domain-containing protein 2	Homo sapiens (Human)			nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730
GN001284	GN001284.1	Q9Y289	53.4	88	107	635	1.08e-22	94.4	SC5A6_HUMAN	Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6)	Homo sapiens (Human)	biotin import across plasma membrane [GO:1905135]; biotin metabolic process [GO:0006768]; biotin transport [GO:0015878]; iodide transmembrane transport [GO:1904200]; pantothenate transmembrane transport [GO:0015887]; sodium ion transport [GO:0006814]; transport across blood-brain barrier [GO:0150104]	biotin transmembrane transporter activity [GO:0015225]; iodide transmembrane transporter activity [GO:0015111]; pantothenate transmembrane transporter activity [GO:0015233]; pantothenate:sodium symporter activity [GO:0015498]; sodium-dependent multivitamin transmembrane transporter activity [GO:0008523]; vitamin transmembrane transporter activity [GO:0090482]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0006768; GO:0006814; GO:0008523; GO:0009925; GO:0015111; GO:0015225; GO:0015233; GO:0015498; GO:0015878; GO:0015887; GO:0016020; GO:0016323; GO:0016324; GO:0031526; GO:0090482; GO:0150104; GO:1904200; GO:1905135
GN001285	GN001285.1	Q5I0M2	52.6	57	88	299	5.03e-13	65.5	NADC_RAT	Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase)	Rattus norvegicus (Rat)	'de novo' NAD+ biosynthetic process from L-tryptophan [GO:0034354]; NAD+ biosynthetic process [GO:0009435]; quinolinate catabolic process [GO:0034213]; quinolinate metabolic process [GO:0046874]	identical protein binding [GO:0042802]; nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514]	catalytic complex [GO:1902494]; cytosol [GO:0005829]	GO:0004514; GO:0005829; GO:0009435; GO:0034213; GO:0034354; GO:0042802; GO:0046874; GO:1902494
GN001286	GN001286.1	Q99700	40.8	76	105	1313	2.52e-09	56.2	ATX2_HUMAN	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	Homo sapiens (Human)	negative regulation of receptor internalization [GO:0002091]; P-body assembly [GO:0033962]; regulation of translation [GO:0006417]; RNA metabolic process [GO:0016070]; RNA transport [GO:0050658]; stress granule assembly [GO:0034063]	epidermal growth factor receptor binding [GO:0005154]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; trans-Golgi network [GO:0005802]	GO:0002091; GO:0003723; GO:0005154; GO:0005737; GO:0005794; GO:0005802; GO:0006417; GO:0010494; GO:0016020; GO:0016070; GO:0033962; GO:0034063; GO:0048471; GO:0050658; GO:1990904
GN001287	GN001287.1	Q9BXI6	59.4	330	383	508	5.78e-141	413	TB10A_HUMAN	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha)	Homo sapiens (Human)	positive regulation of proteolysis [GO:0045862]; retrograde transport, endosome to Golgi [GO:0042147]	cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; PDZ domain binding [GO:0030165]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	GO:0005096; GO:0005829; GO:0005886; GO:0005902; GO:0030165; GO:0042147; GO:0045296; GO:0045862; GO:0070062
GN001291	GN001291.1	Q5RGB8	27.4	496	542	605	1.24e-55	200	KLH26_DANRE	Kelch-like protein 26	Danio rerio (Zebrafish) (Brachydanio rerio)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]	GO:0031463; GO:0043161; GO:1990756
GN001293	GN001293.1	A2BGA0	71.8	436	552	735	7.30e-230	655	RFX4_DANRE	Transcription factor RFX4 (Regulatory factor X 4)	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of transcription by RNA polymerase II [GO:0006357]; ventral midline development [GO:0007418]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0007418
GN001295	GN001295.1	A0JN52	82.0	1205	1207	1217	0.0	2016	SF3B3_BOVIN	Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (Spliceosome-associated protein 130) (SAP 130)	Bos taurus (Bovine)	mRNA splicing, via spliceosome [GO:0000398]; negative regulation of protein catabolic process [GO:0042177]	protein-containing complex binding [GO:0044877]; U2 snRNA binding [GO:0030620]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U11/U12 snRNP [GO:0034693]; U12-type catalytic step 2 spliceosome [GO:0071018]; U12-type precatalytic spliceosome [GO:0071016]; U2 snRNP [GO:0005686]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	GO:0000398; GO:0005634; GO:0005654; GO:0005684; GO:0005686; GO:0005730; GO:0030620; GO:0034693; GO:0042177; GO:0044877; GO:0071005; GO:0071006; GO:0071016; GO:0071018
GN001299	GN001299.1	Q92614	43.5	1652	1716	2054	0.0	1055	MY18A_HUMAN	Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)	Homo sapiens (Human)	actomyosin structure organization [GO:0031032]; asymmetric Golgi ribbon formation [GO:0090164]; cell migration [GO:0016477]; DNA metabolic process [GO:0006259]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi vesicle budding [GO:0048194]; negative regulation of apoptotic process [GO:0043066]; positive regulation of opsonization [GO:1903028]; positive regulation of protein secretion [GO:0050714]; regulation of macrophage activation [GO:0043030]	actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; RNA binding [GO:0003723]	actomyosin [GO:0042641]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; postsynaptic Golgi apparatus [GO:0150051]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0003677; GO:0003723; GO:0005524; GO:0005737; GO:0005793; GO:0005794; GO:0005802; GO:0005815; GO:0006259; GO:0007030; GO:0008094; GO:0009986; GO:0016020; GO:0016460; GO:0016477; GO:0031032; GO:0032982; GO:0042641; GO:0043030; GO:0043066; GO:0043531; GO:0048194; GO:0050714; GO:0051015; GO:0090161; GO:0090164; GO:0150051; GO:1903028
GN001300	GN001300.1	D3ZFD0	59.7	119	379	2044	6.90e-34	137	MY18A_RAT	Unconventional myosin-XVIIIa	Rattus norvegicus (Rat)	actomyosin structure organization [GO:0031032]; asymmetric Golgi ribbon formation [GO:0090164]; canonical NF-kappaB signal transduction [GO:0007249]; cell migration [GO:0016477]; cellular response to type II interferon [GO:0071346]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi vesicle budding [GO:0048194]; negative regulation of apoptotic process [GO:0043066]; positive regulation of opsonization [GO:1903028]; positive regulation of protein secretion [GO:0050714]; regulation of macrophage activation [GO:0043030]	actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]	actomyosin [GO:0042641]; brush border [GO:0005903]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; microtubule organizing center [GO:0005815]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; phagocytic vesicle [GO:0045335]; postsynaptic Golgi apparatus [GO:0150051]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0003774; GO:0005524; GO:0005737; GO:0005794; GO:0005802; GO:0005815; GO:0005856; GO:0005903; GO:0007030; GO:0007249; GO:0009986; GO:0016460; GO:0016477; GO:0031032; GO:0032982; GO:0042641; GO:0043030; GO:0043066; GO:0043531; GO:0045335; GO:0048194; GO:0050714; GO:0051015; GO:0071346; GO:0090161; GO:0090164; GO:0150051; GO:1903028
GN001301	GN001301.1	A7SG73	64.4	264	281	289	4.35e-121	350	NADC_NEMVE	Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase)	Nematostella vectensis (Starlet sea anemone)	NAD+ biosynthetic process [GO:0009435]; quinolinate catabolic process [GO:0034213]	nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514]		GO:0004514; GO:0009435; GO:0034213
GN001303	GN001303.1	Q99700	40.5	79	96	1313	8.65e-09	54.3	ATX2_HUMAN	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	Homo sapiens (Human)	negative regulation of receptor internalization [GO:0002091]; P-body assembly [GO:0033962]; regulation of translation [GO:0006417]; RNA metabolic process [GO:0016070]; RNA transport [GO:0050658]; stress granule assembly [GO:0034063]	epidermal growth factor receptor binding [GO:0005154]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; trans-Golgi network [GO:0005802]	GO:0002091; GO:0003723; GO:0005154; GO:0005737; GO:0005794; GO:0005802; GO:0006417; GO:0010494; GO:0016020; GO:0016070; GO:0033962; GO:0034063; GO:0048471; GO:0050658; GO:1990904
GN001304	GN001304.1	Q99700	42.7	211	749	1313	1.14e-31	136	ATX2_HUMAN	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	Homo sapiens (Human)	negative regulation of receptor internalization [GO:0002091]; P-body assembly [GO:0033962]; regulation of translation [GO:0006417]; RNA metabolic process [GO:0016070]; RNA transport [GO:0050658]; stress granule assembly [GO:0034063]	epidermal growth factor receptor binding [GO:0005154]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; trans-Golgi network [GO:0005802]	GO:0002091; GO:0003723; GO:0005154; GO:0005737; GO:0005794; GO:0005802; GO:0006417; GO:0010494; GO:0016020; GO:0016070; GO:0033962; GO:0034063; GO:0048471; GO:0050658; GO:1990904
GN001305	GN001305.1	A7SG73	61.2	183	200	289	8.20e-78	237	NADC_NEMVE	Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase)	Nematostella vectensis (Starlet sea anemone)	NAD+ biosynthetic process [GO:0009435]; quinolinate catabolic process [GO:0034213]	nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514]		GO:0004514; GO:0009435; GO:0034213
GN001306	GN001306.1	D3ZFD0	59.7	119	379	2044	6.90e-34	137	MY18A_RAT	Unconventional myosin-XVIIIa	Rattus norvegicus (Rat)	actomyosin structure organization [GO:0031032]; asymmetric Golgi ribbon formation [GO:0090164]; canonical NF-kappaB signal transduction [GO:0007249]; cell migration [GO:0016477]; cellular response to type II interferon [GO:0071346]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi vesicle budding [GO:0048194]; negative regulation of apoptotic process [GO:0043066]; positive regulation of opsonization [GO:1903028]; positive regulation of protein secretion [GO:0050714]; regulation of macrophage activation [GO:0043030]	actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]	actomyosin [GO:0042641]; brush border [GO:0005903]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; microtubule organizing center [GO:0005815]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]; phagocytic vesicle [GO:0045335]; postsynaptic Golgi apparatus [GO:0150051]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0003774; GO:0005524; GO:0005737; GO:0005794; GO:0005802; GO:0005815; GO:0005856; GO:0005903; GO:0007030; GO:0007249; GO:0009986; GO:0016460; GO:0016477; GO:0031032; GO:0032982; GO:0042641; GO:0043030; GO:0043066; GO:0043531; GO:0045335; GO:0048194; GO:0050714; GO:0051015; GO:0071346; GO:0090161; GO:0090164; GO:0150051; GO:1903028
GN001311	GN001311.1	Q5SWT3	53.4	298	306	300	3.88e-114	334	S2535_MOUSE	Solute carrier family 25 member 35	Mus musculus (Mouse)			mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743
GN001312	GN001312.1	Q8BLQ7	49.2	581	638	635	4.17e-172	507	CTR4_MOUSE	Cationic amino acid transporter 4 (CAT-4) (CAT4) (Solute carrier family 7 member 4)	Mus musculus (Mouse)	amino acid transport [GO:0006865]	amino acid transmembrane transporter activity [GO:0015171]; carboxylic acid transmembrane transporter activity [GO:0046943]	plasma membrane [GO:0005886]	GO:0005886; GO:0006865; GO:0015171; GO:0046943
GN001313	GN001313.1	Q6ZUK4	43.4	173	274	368	3.68e-28	114	TMM26_HUMAN	Transmembrane protein 26	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN001314	GN001314.1	Q04917	59.5	247	251	246	8.94e-91	271	1433F_HUMAN	14-3-3 protein eta (Protein AS1)	Homo sapiens (Human)	glucocorticoid catabolic process [GO:0006713]; intracellular protein localization [GO:0008104]; intracellular protein transport [GO:0006886]; membrane depolarization during action potential [GO:0086010]; negative regulation of dendrite morphogenesis [GO:0050774]; nuclear receptor-mediated glucocorticoid signaling pathway [GO:0042921]; positive regulation of DNA-templated transcription [GO:0045893]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of neuron differentiation [GO:0045664]; regulation of sodium ion transport [GO:0002028]; regulation of synaptic plasticity [GO:0048167]; substantia nigra development [GO:0021762]	actin binding [GO:0003779]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; insulin-like growth factor receptor binding [GO:0005159]; nuclear glucocorticoid receptor binding [GO:0035259]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]	cerebellar granule cell to Purkinje cell synapse [GO:0150048]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0002028; GO:0003779; GO:0005159; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006713; GO:0006886; GO:0008104; GO:0014704; GO:0017080; GO:0019899; GO:0019904; GO:0021762; GO:0035259; GO:0042802; GO:0042921; GO:0044325; GO:0045664; GO:0045893; GO:0046982; GO:0048167; GO:0050774; GO:0070062; GO:0086010; GO:0098793; GO:0099171; GO:0150048
GN001315	GN001315.1	Q7T356	58.4	243	249	242	2.25e-87	262	143BB_DANRE	14-3-3 protein beta/alpha-B	Danio rerio (Zebrafish) (Brachydanio rerio)	intracellular protein localization [GO:0008104]		cytoplasm [GO:0005737]	GO:0005737; GO:0008104
GN001316	GN001316.1	Q9JHX4	31.9	279	532	482	3.21e-33	135	CASP8_RAT	Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]	Rattus norvegicus (Rat)	angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; heart development [GO:0007507]; hepatocyte apoptotic process [GO:0097284]; macrophage differentiation [GO:0030225]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of necroptotic process [GO:0060546]; neural tube formation [GO:0001841]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of proteolysis [GO:0045862]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of cytokine production [GO:0001817]; regulation of innate immune response [GO:0045088]; regulation of thymocyte apoptotic process [GO:0070243]; response to anesthetic [GO:0072347]; response to auditory stimulus [GO:0010996]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; self proteolysis [GO:0097264]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; ubiquitin protein ligase binding [GO:0031625]	caspase complex [GO:0008303]; CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; lamellipodium [GO:0030027]; Noc1p-Noc2p complex [GO:0030690]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ripoptosome [GO:0097342]	GO:0001525; GO:0001817; GO:0001841; GO:0004175; GO:0004197; GO:0005123; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006508; GO:0006915; GO:0007507; GO:0008233; GO:0008303; GO:0008625; GO:0008656; GO:0010996; GO:0016485; GO:0030027; GO:0030163; GO:0030225; GO:0030335; GO:0030690; GO:0031264; GO:0031265; GO:0031625; GO:0032025; GO:0032355; GO:0032496; GO:0032731; GO:0032991; GO:0034612; GO:0035877; GO:0036462; GO:0042802; GO:0043065; GO:0043123; GO:0043124; GO:0043525; GO:0044297; GO:0044877; GO:0045088; GO:0045471; GO:0045651; GO:0045862; GO:0051604; GO:0060546; GO:0070243; GO:0070269; GO:0071260; GO:0072347; GO:0097110; GO:0097190; GO:0097191; GO:0097194; GO:0097264; GO:0097284; GO:0097342; GO:1900119; GO:2001233; GO:2001238
GN001317	GN001317.1	P07314	45.8	297	298	568	3.38e-78	251	GGT1_RAT	Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]	Rattus norvegicus (Rat)	amino acid metabolic process [GO:0006520]; cellular response to oxidative stress [GO:0034599]; fatty acid metabolic process [GO:0006631]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; hepatoblast differentiation [GO:0061017]; hepatocyte differentiation [GO:0070365]; L-cysteine biosynthetic process [GO:0019344]; leukotriene D4 biosynthetic process [GO:1901750]; leukotriene metabolic process [GO:0006691]; liver regeneration [GO:0097421]; peptide modification [GO:0031179]; proteolysis [GO:0006508]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; response to alcohol [GO:0097305]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; spermatogenesis [GO:0007283]; zymogen activation [GO:0031638]	aminoacyltransferase activity [GO:0016755]; glutathione gamma-glutamate hydrolase [GO:0036374]; leukotriene-C(4) hydrolase activity [GO:0002951]; peptidyltransferase activity [GO:0000048]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GO:0000048; GO:0002682; GO:0002951; GO:0005576; GO:0005886; GO:0006508; GO:0006520; GO:0006536; GO:0006631; GO:0006691; GO:0006750; GO:0006751; GO:0007283; GO:0016755; GO:0019344; GO:0031179; GO:0031638; GO:0031982; GO:0032355; GO:0032496; GO:0034599; GO:0034612; GO:0036374; GO:0050727; GO:0061017; GO:0070365; GO:0097305; GO:0097421; GO:1901750
GN001318	GN001318.1	P07314	48.5	544	612	568	9.16e-158	467	GGT1_RAT	Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]	Rattus norvegicus (Rat)	amino acid metabolic process [GO:0006520]; cellular response to oxidative stress [GO:0034599]; fatty acid metabolic process [GO:0006631]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; hepatoblast differentiation [GO:0061017]; hepatocyte differentiation [GO:0070365]; L-cysteine biosynthetic process [GO:0019344]; leukotriene D4 biosynthetic process [GO:1901750]; leukotriene metabolic process [GO:0006691]; liver regeneration [GO:0097421]; peptide modification [GO:0031179]; proteolysis [GO:0006508]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; response to alcohol [GO:0097305]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; spermatogenesis [GO:0007283]; zymogen activation [GO:0031638]	aminoacyltransferase activity [GO:0016755]; glutathione gamma-glutamate hydrolase [GO:0036374]; leukotriene-C(4) hydrolase activity [GO:0002951]; peptidyltransferase activity [GO:0000048]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GO:0000048; GO:0002682; GO:0002951; GO:0005576; GO:0005886; GO:0006508; GO:0006520; GO:0006536; GO:0006631; GO:0006691; GO:0006750; GO:0006751; GO:0007283; GO:0016755; GO:0019344; GO:0031179; GO:0031638; GO:0031982; GO:0032355; GO:0032496; GO:0034599; GO:0034612; GO:0036374; GO:0050727; GO:0061017; GO:0070365; GO:0097305; GO:0097421; GO:1901750
GN001320	GN001320.1	A5HK05	74.1	274	303	585	1.13e-92	289	APBP2_RAT	Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2)	Rattus norvegicus (Rat)	intracellular protein transport [GO:0006886]; negative regulation of beige fat cell differentiation [GO:0160276]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005856; GO:0006886; GO:0016020; GO:0016567; GO:0030659; GO:0031462; GO:0043161; GO:0140627; GO:0160276; GO:1990756
GN001323	GN001323.1	Q99JA8	30.8	130	145	151	4.72e-13	65.5	NGB_RAT	Neuroglobin (Nitrite reductase) (EC 1.7.-.-)	Rattus norvegicus (Rat)	cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; negative regulation of apoptotic process [GO:0043066]; neuron projection development [GO:0031175]; oxygen transport [GO:0015671]; positive regulation of catalytic activity [GO:0043085]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]	GDP-dissociation inhibitor activity [GO:0005092]; heme binding [GO:0020037]; nitrite reductase activity [GO:0098809]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; perikaryon [GO:0043204]	GO:0001666; GO:0005092; GO:0005344; GO:0005759; GO:0005829; GO:0010039; GO:0015671; GO:0019825; GO:0020037; GO:0031175; GO:0043066; GO:0043085; GO:0043204; GO:0070301; GO:0071456; GO:0098809
GN001324	GN001324.1	Q7JK24	33.1	299	306	326	2.30e-50	172	B3GT1_GORGO	Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)	Gorilla gorilla gorilla (Western lowland gorilla)	glucosylceramide metabolic process [GO:0006678]; glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006678; GO:0008499; GO:0009101; GO:0009312
GN001327	GN001327.1	Q5BL38	50.7	341	362	394	1.20e-117	349	CEGT_XENTR	Ceramide glucosyltransferase (EC 2.4.1.80) (Glycosylceramide synthase) (UDP-glucose ceramide glucosyltransferase)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	glycosphingolipid catabolic process [GO:0046479]	ceramide glucosyltransferase activity [GO:0008120]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0005794; GO:0008120; GO:0016020; GO:0046479
GN001329	GN001329.1	Q8VC97	58.7	121	125	393	5.67e-41	142	BUP1_MOUSE	Beta-ureidopropionase (EC 3.5.1.6) (Beta-alanine synthase) (N-carbamoyl-beta-alanine amidohydrolase)	Mus musculus (Mouse)	beta-alanine biosynthetic process [GO:0019483]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dTMP catabolic process [GO:0046074]; dUMP catabolic process [GO:0046079]; in utero embryonic development [GO:0001701]; liver development [GO:0001889]; protein homooligomerization [GO:0051260]; protein homotetramerization [GO:0051289]; pyrimidine nucleoside catabolic process [GO:0046135]; UMP catabolic process [GO:0046050]	beta-ureidopropionase activity [GO:0003837]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]	GO:0001701; GO:0001889; GO:0003837; GO:0005829; GO:0006248; GO:0006249; GO:0008270; GO:0019483; GO:0042803; GO:0046050; GO:0046074; GO:0046079; GO:0046135; GO:0051260; GO:0051289
GN001330	GN001330.1	Q9CWQ2	45.6	136	159	152	9.38e-33	116	ZSWM7_MOUSE	Zinc finger SWIM domain-containing protein 7 (SWIM domain-containing and Srs2-interacting protein 1 homolog)	Mus musculus (Mouse)	DNA recombinase assembly [GO:0000730]; double-strand break repair involved in meiotic recombination [GO:1990918]; double-strand break repair via homologous recombination [GO:0000724]; protein stabilization [GO:0050821]	zinc ion binding [GO:0008270]	chromosome [GO:0005694]; nucleus [GO:0005634]; Shu complex [GO:0097196]	GO:0000724; GO:0000730; GO:0005634; GO:0005694; GO:0008270; GO:0050821; GO:0097196; GO:1990918
GN001331	GN001331.1	Q2KN95	32.7	831	1067	1113	5.65e-81	290	CYTSA_TETNG	Cytospin-A (SPECC1-like protein) (Sperm antigen with calponin homology and coiled-coil domains 1-like)	Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)			gap junction [GO:0005921]; spindle [GO:0005819]	GO:0005819; GO:0005921
GN001332	GN001332.1	Q05AW9	52.3	352	482	508	4.22e-119	361	SMG9_XENLA	Nonsense-mediated mRNA decay factor SMG9 (Protein smg-9 homolog)	Xenopus laevis (African clawed frog)	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]			GO:0000184
GN001333	GN001333.1	P27365	32.6	359	358	373	6.87e-41	150	3BHS1_MACMU	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1)	Macaca mulatta (Rhesus macaque)	androgen biosynthetic process [GO:0006702]; C21-steroid hormone metabolic process [GO:0008207]; steroid biosynthetic process [GO:0006694]	3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854]; 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity [GO:0000253]; 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity [GO:0047024]; steroid Delta-isomerase activity [GO:0004769]	ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]	GO:0000253; GO:0003854; GO:0004769; GO:0005737; GO:0005789; GO:0006694; GO:0006702; GO:0008207; GO:0031966; GO:0035869; GO:0047024
GN001334	GN001334.1	C4N147	35.2	88	128	132	1.16e-11	60.8	FABP1_DORPE	Sodium/calcium exchanger regulatory protein 1 (ReP1-NCXSQ) (Fatty acid-binding protein 1) (Na(+)/Ca(2+) exchanger regulatory protein 1)	Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)		lipid binding [GO:0008289]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0005737; GO:0008289; GO:0016020
GN001336	GN001336.1	Q9QZ67	51.9	183	206	598	1.35e-58	196	PPM1D_MOUSE	Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)	Mus musculus (Mouse)	cellular response to starvation [GO:0009267]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of gene expression, epigenetic [GO:0045814]; peptidyl-threonine dephosphorylation [GO:0035970]; regulation of intracellular signal transduction [GO:1902531]; response to bacterium [GO:0009617]	cation binding [GO:0043169]; mitogen-activated protein kinase binding [GO:0051019]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000086; GO:0004722; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0006346; GO:0009267; GO:0009617; GO:0030330; GO:0035970; GO:0043169; GO:0045814; GO:0051019; GO:1902531
GN001340	GN001340.1	O36022	35.9	273	375	337	1.41e-37	141	MNN9_SCHPO	Mannan polymerase complex subunit mnn9	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	cell wall mannoprotein biosynthetic process [GO:0000032]; protein N-linked glycosylation [GO:0006487]	mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mannan polymerase complex [GO:0000136]; mannan polymerase II complex [GO:0140497]	GO:0000030; GO:0000032; GO:0000136; GO:0000139; GO:0005783; GO:0005789; GO:0005794; GO:0006487; GO:0140497
GN001347	GN001347.1	Q8CEE7	41.2	243	350	334	7.71e-49	170	RDH13_MOUSE	Retinol dehydrogenase 13 (EC 1.1.1.300)	Mus musculus (Mouse)	eye photoreceptor cell development [GO:0042462]; response to high light intensity [GO:0009644]; retina layer formation [GO:0010842]; retinal metabolic process [GO:0042574]	all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0009644; GO:0010842; GO:0042462; GO:0042574; GO:0052650
GN001348	GN001348.1	Q5XGK0	56.4	454	524	526	2.63e-171	497	SPNS1_XENLA	Protein spinster homolog 1 (Spns1)	Xenopus laevis (African clawed frog)		transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]; membrane [GO:0016020]	GO:0005765; GO:0016020; GO:0022857
GN001362	GN001362.1	Q9Y4C8	46.5	975	908	960	2.97e-249	726	RBM19_HUMAN	Probable RNA-binding protein 19 (RNA-binding motif protein 19)	Homo sapiens (Human)	positive regulation of embryonic development [GO:0040019]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	RNA binding [GO:0003723]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0000381; GO:0003723; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0016020; GO:0040019
GN001366	GN001366.1	P0CT33	38.0	92	176	1887	1.92e-13	70.9	TLH1_SCHPO	ATP-dependent DNA helicase tlh1 (EC 5.6.2.4) (DNA 3'-5' helicase tlh1) (Sub-telomeric helicase RecQ homolog 1) (Telomere-linked helicase 1)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	telomere maintenance via recombination [GO:0000722]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; chromosome, telomeric repeat region [GO:0140445]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000722; GO:0003676; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0008270; GO:0016887; GO:0043138; GO:0140445
GN001372	GN001372.1	P0AFQ9	29.5	210	835	265	3.13e-12	71.2	YCFH_ECO57	Uncharacterized metal-dependent hydrolase YcfH (EC 3.1.-.-)	Escherichia coli O157:H7		DNA nuclease activity [GO:0004536]; hydrolase activity, acting on ester bonds [GO:0016788]	cytosol [GO:0005829]	GO:0004536; GO:0005829; GO:0016788
GN001378	GN001378.1	P26439	34.6	185	214	372	3.16e-19	87.8	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) (3-beta-HSD adrenal and gonadal type) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)]	Homo sapiens (Human)	androgen biosynthetic process [GO:0006702]; C21-steroid hormone metabolic process [GO:0008207]; steroid biosynthetic process [GO:0006694]	3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854]; steroid Delta-isomerase activity [GO:0004769]	ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; smooth endoplasmic reticulum membrane [GO:0030868]	GO:0003854; GO:0004769; GO:0005737; GO:0005743; GO:0005758; GO:0005783; GO:0005789; GO:0006694; GO:0006702; GO:0008207; GO:0016020; GO:0030868; GO:0031966; GO:0035869; GO:0045171
GN001379	GN001379.1	Q7K4Y6	63.0	579	635	631	3.43e-264	741	DAT_DROME	Sodium-dependent dopamine transporter (Protein fumin)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; amino acid transport [GO:0006865]; circadian sleep/wake cycle [GO:0042745]; dopamine uptake [GO:0090494]; dopamine uptake involved in synaptic transmission [GO:0051583]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; response to odorant [GO:1990834]; sleep [GO:0030431]; sodium ion transmembrane transport [GO:0035725]	cocaine binding [GO:0019811]; dopamine:sodium symporter activity [GO:0005330]	axon [GO:0030424]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	GO:0005330; GO:0005886; GO:0006865; GO:0008344; GO:0019811; GO:0030424; GO:0030431; GO:0032809; GO:0035725; GO:0042734; GO:0042745; GO:0051583; GO:0090494; GO:0099509; GO:1990834
GN001381	GN001381.1	Q04678	55.0	629	750	706	1.64e-214	622	SSRP1_CHICK	FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (T160)	Gallus gallus (Chicken)	regulation of chromatin organization [GO:1902275]	DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0005694; GO:0005730; GO:0031491; GO:0042393; GO:1902275
GN001383	GN001383.1	Q04678	65.9	44	65	706	5.43e-13	64.7	SSRP1_CHICK	FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (T160)	Gallus gallus (Chicken)	regulation of chromatin organization [GO:1902275]	DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0005694; GO:0005730; GO:0031491; GO:0042393; GO:1902275
GN001384	GN001384.1	Q04678	47.7	132	155	706	1.96e-16	78.6	SSRP1_CHICK	FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (T160)	Gallus gallus (Chicken)	regulation of chromatin organization [GO:1902275]	DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0005694; GO:0005730; GO:0031491; GO:0042393; GO:1902275
GN001387	GN001387.1	Q9VT65	38.9	506	572	925	1.40e-118	375	CANB_DROME	Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2]	Drosophila melanogaster (Fruit fly)	border follicle cell migration [GO:0007298]; neuron remodeling [GO:0016322]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0004198; GO:0005509; GO:0005737; GO:0006508; GO:0007298; GO:0016020; GO:0016322; GO:0016540
GN001391	GN001391.1	Q09660	37.5	371	410	489	1.14e-79	256	CC44_CAEEL	Probable cytochrome P450 CYP44 (EC 1.14.-.-)	Caenorhabditis elegans		heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]		GO:0004497; GO:0005506; GO:0016705; GO:0020037
GN001393	GN001393.1	Q9PTS8	25.8	368	412	484	1.01e-25	112	ACHA9_CHICK	Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0097060; GO:1902495
GN001395	GN001395.1	B0JZG0	48.5	497	599	649	4.44e-150	450	S23A2_XENTR	Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	L-ascorbic acid transmembrane transport [GO:0015882]	L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0005886; GO:0008520; GO:0015229; GO:0015882; GO:0016324
GN001396	GN001396.1	P42325	59.7	186	187	190	2.02e-79	237	NCAH_DROME	Neurocalcin homolog (DrosNCa)	Drosophila melanogaster (Fruit fly)	negative regulation of neuronal signal transduction [GO:1902848]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; regulation of signal transduction [GO:0009966]	calcium ion binding [GO:0005509]		GO:0005509; GO:0009966; GO:0045938; GO:1902848
GN001397	GN001397.1	P55088	44.6	260	315	323	2.12e-66	214	AQP4_MOUSE	Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)	Mus musculus (Mouse)	carbon dioxide transport [GO:0015670]; cell-cell adhesion [GO:0098609]; cellular response to glucose stimulus [GO:0071333]; cellular response to type II interferon [GO:0071346]; cerebrospinal fluid circulation [GO:0090660]; cerebrospinal fluid secretion [GO:0033326]; intracellular water homeostasis [GO:0009992]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; protein homotetramerization [GO:0051289]; regulation of vascular endothelial growth factor production [GO:0010574]; renal water absorption [GO:0070295]; sensory perception of sound [GO:0007605]; water transport [GO:0006833]	identical protein binding [GO:0042802]; water channel activity [GO:0015250]	astrocyte end-foot [GO:0097450]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]	GO:0005576; GO:0005737; GO:0005886; GO:0005911; GO:0006833; GO:0007605; GO:0009897; GO:0009925; GO:0009992; GO:0010008; GO:0010574; GO:0015250; GO:0015670; GO:0016020; GO:0016323; GO:0030054; GO:0030315; GO:0031253; GO:0032691; GO:0032715; GO:0032991; GO:0033326; GO:0042383; GO:0042802; GO:0050891; GO:0051289; GO:0060354; GO:0070295; GO:0071333; GO:0071346; GO:0090660; GO:0097450; GO:0098609
GN001400	GN001400.1	P55088	50.8	248	318	323	4.15e-84	259	AQP4_MOUSE	Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)	Mus musculus (Mouse)	carbon dioxide transport [GO:0015670]; cell-cell adhesion [GO:0098609]; cellular response to glucose stimulus [GO:0071333]; cellular response to type II interferon [GO:0071346]; cerebrospinal fluid circulation [GO:0090660]; cerebrospinal fluid secretion [GO:0033326]; intracellular water homeostasis [GO:0009992]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; protein homotetramerization [GO:0051289]; regulation of vascular endothelial growth factor production [GO:0010574]; renal water absorption [GO:0070295]; sensory perception of sound [GO:0007605]; water transport [GO:0006833]	identical protein binding [GO:0042802]; water channel activity [GO:0015250]	astrocyte end-foot [GO:0097450]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]	GO:0005576; GO:0005737; GO:0005886; GO:0005911; GO:0006833; GO:0007605; GO:0009897; GO:0009925; GO:0009992; GO:0010008; GO:0010574; GO:0015250; GO:0015670; GO:0016020; GO:0016323; GO:0030054; GO:0030315; GO:0031253; GO:0032691; GO:0032715; GO:0032991; GO:0033326; GO:0042383; GO:0042802; GO:0050891; GO:0051289; GO:0060354; GO:0070295; GO:0071333; GO:0071346; GO:0090660; GO:0097450; GO:0098609
GN001402	GN001402.1	Q66L58	64.0	264	407	771	1.90e-112	349	VAC14_DANRE	Protein VAC14 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	phosphatidylinositol biosynthetic process [GO:0006661]		endosome membrane [GO:0010008]; PAS complex [GO:0070772]	GO:0006661; GO:0010008; GO:0070772
GN001403	GN001403.1	Q66L58	40.1	334	318	771	3.03e-55	194	VAC14_DANRE	Protein VAC14 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	phosphatidylinositol biosynthetic process [GO:0006661]		endosome membrane [GO:0010008]; PAS complex [GO:0070772]	GO:0006661; GO:0010008; GO:0070772
GN001404	GN001404.1	Q9Y4A0	27.0	318	458	524	3.07e-10	65.9	JERKL_HUMAN	Jerky protein homolog-like (Human homolog of mouse jerky gene protein) (HHMJG)	Homo sapiens (Human)	central nervous system development [GO:0007417]	DNA binding [GO:0003677]	nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0007417
GN001405	GN001405.1	Q68F38	52.3	86	103	782	3.96e-16	75.5	VAC14_XENLA	Protein VAC14 homolog	Xenopus laevis (African clawed frog)	phosphatidylinositol biosynthetic process [GO:0006661]		endosome membrane [GO:0010008]; PAS complex [GO:0070772]	GO:0006661; GO:0010008; GO:0070772
GN001406	GN001406.1	Q6NV18	29.5	193	241	309	9.67e-09	58.2	NHEJ1_DANRE	Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor)	Danio rerio (Zebrafish) (Brachydanio rerio)	double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; telomere maintenance [GO:0000723]	DNA end binding [GO:0045027]	chromosome [GO:0005694]; DNA ligase IV complex [GO:0032807]; nonhomologous end joining complex [GO:0070419]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000723; GO:0005634; GO:0005694; GO:0006303; GO:0032807; GO:0033152; GO:0035861; GO:0045027; GO:0070419
GN001407	GN001407.1	Q6GMV2	24.4	406	737	418	4.67e-16	84.7	SMYD5_HUMAN	Protein-lysine N-trimethyltransferase SMYD5 (EC 2.1.1.-) (Protein NN8-4AG) (Retinoic acid-induced protein 15) (SET and MYND domain-containing protein 5) ([histone H3]-lysine20 N-trimethyltransferase SMYD5) (EC 2.1.1.372) ([histone H4]-lysine36 N-trimethyltransferase SMYD5) (EC 2.1.1.359)	Homo sapiens (Human)	negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of cytoplasmic translational elongation [GO:1900249]; regulation of stem cell differentiation [GO:2000736]; regulation of stem cell division [GO:2000035]; transposable element silencing by heterochromatin formation [GO:0141005]	histone H3K36 trimethyltransferase activity [GO:0140955]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 trimethyltransferase activity [GO:0140943]; protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]	GO:0005737; GO:0016279; GO:0042799; GO:0045814; GO:0140943; GO:0140955; GO:0141005; GO:1900249; GO:2000035; GO:2000736
GN001408	GN001408.1	Q9I9A7	45.7	381	715	617	6.43e-95	310	CDT1_XENLA	DNA replication factor Cdt1 (XCDT1)	Xenopus laevis (African clawed frog)	DNA replication checkpoint signaling [GO:0000076]; DNA replication preinitiation complex assembly [GO:0071163]; mitotic cell cycle [GO:0000278]; regulation of DNA-templated DNA replication initiation [GO:0030174]	chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]	nucleus [GO:0005634]	GO:0000076; GO:0000278; GO:0003677; GO:0005634; GO:0030174; GO:0031490; GO:0070182; GO:0071163
GN001409	GN001409.1	Q9NWV4	57.6	158	162	160	3.10e-63	194	CZIB_HUMAN	CXXC motif containing zinc binding protein (UPF0587 protein C1orf123)	Homo sapiens (Human)		zinc ion binding [GO:0008270]		GO:0008270
GN001412	GN001412.1	Q4ZJM9	30.9	110	364	238	8.35e-10	62.0	C1QL4_MOUSE	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11)	Mus musculus (Mouse)	maintenance of synapse structure [GO:0099558]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular region [GO:0005576]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0005576; GO:0042802; GO:0043083; GO:0045202; GO:0045599; GO:0048147; GO:0070373; GO:0099550; GO:0099558
GN001413	GN001413.1	Q20929	27.7	347	393	510	9.09e-26	112	DMSR1_CAEEL	G protein-coupled receptor dmsr-1 (Dromyosuppressin receptor related 1)	Caenorhabditis elegans	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of cellular response to heat [GO:1900034]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008188; GO:0008528; GO:0032809; GO:0045187; GO:1900034
GN001414	GN001414.1	Q20929	28.5	344	372	510	2.20e-30	124	DMSR1_CAEEL	G protein-coupled receptor dmsr-1 (Dromyosuppressin receptor related 1)	Caenorhabditis elegans	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of cellular response to heat [GO:1900034]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008188; GO:0008528; GO:0032809; GO:0045187; GO:1900034
GN001419	GN001419.1	Q8MJ08	30.8	341	344	492	7.20e-36	139	PE2R4_BOVIN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0007188; GO:0007189; GO:0007204; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN001423	GN001423.1	Q7YR26	68.2	556	913	767	9.44e-275	785	TOP1_CHLAE	DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)	Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)	chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; circadian regulation of gene expression [GO:0032922]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0003677; GO:0003682; GO:0003917; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0006260; GO:0006265; GO:0006338; GO:0007059; GO:0032922
GN001425	GN001425.1	Q8MP06	42.9	91	150	456	2.66e-09	57.8	SNO1_TYRJA	Senecionine N-oxygenase (SNO) (EC 1.14.13.101)	Tyria jacobaeae (Cinnabar moth)	alkaloid metabolic process [GO:0009820]; protein homotetramerization [GO:0051289]	flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; senecionine N-oxygenase activity [GO:0033784]	extracellular region [GO:0005576]	GO:0004499; GO:0005576; GO:0009820; GO:0033784; GO:0050660; GO:0050661; GO:0051289
GN001426	GN001426.1	Q94BV5	36.9	298	338	452	4.10e-59	199	GSXL4_ARATH	Flavin-containing monooxygenase FMO GS-OX-like 4 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 4)	Arabidopsis thaliana (Mouse-ear cress)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	nucleus [GO:0005634]; plant-type vacuole [GO:0000325]	GO:0000325; GO:0004499; GO:0005634; GO:0050660; GO:0050661
GN001427	GN001427.1	Q93Y23	43.8	121	118	461	1.07e-17	80.5	GSOX4_ARATH	Flavin-containing monooxygenase FMO GS-OX4 (EC 1.14.13.237) (Flavin-monooxygenase glucosinolate S-oxygenase 4)	Arabidopsis thaliana (Mouse-ear cress)	glucosinolate biosynthetic process [GO:0019761]	4-methylthiopropyl glucosinolate S-oxygenase activity [GO:0080103]; 8-methylthiopropyl glucosinolate S-oxygenase activity [GO:0080107]; flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	nucleus [GO:0005634]	GO:0004499; GO:0005634; GO:0019761; GO:0050660; GO:0050661; GO:0080103; GO:0080107
GN001428	GN001428.1	Q94BV5	35.9	217	257	452	2.61e-41	150	GSXL4_ARATH	Flavin-containing monooxygenase FMO GS-OX-like 4 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 4)	Arabidopsis thaliana (Mouse-ear cress)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	nucleus [GO:0005634]; plant-type vacuole [GO:0000325]	GO:0000325; GO:0004499; GO:0005634; GO:0050660; GO:0050661
GN001429	GN001429.1	V5NAL9	32.5	781	807	899	1.54e-110	361	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN001430	GN001430.1	A3SLM3	45.7	70	67	447	2.21e-10	57.4	TMM_ROSNI	Trimethylamine monooxygenase (TMA monooxygenase) (Tmm) (EC 1.14.13.148)	Roseovarius nubinhibens (strain ATCC BAA-591 / DSM 15170 / ISM)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]		GO:0004499; GO:0034899; GO:0050660; GO:0050661
GN001431	GN001431.1	Q9SXD5	37.0	243	315	450	2.24e-52	181	GSXL3_ARATH	Flavin-containing monooxygenase FMO GS-OX-like 3 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 3)	Arabidopsis thaliana (Mouse-ear cress)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	nucleus [GO:0005634]	GO:0004499; GO:0005634; GO:0050660; GO:0050661
GN001432	GN001432.1	Q5R541	32.2	171	337	296	2.95e-09	60.8	GEM_PONAB	GTP-binding protein GEM	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)		calcium channel regulator activity [GO:0005246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]	GO:0003924; GO:0005246; GO:0005525; GO:0005886
GN001437	GN001437.1	Q8K2V1	59.8	132	175	951	8.74e-42	152	PP4R1_MOUSE	Serine/threonine-protein phosphatase 4 regulatory subunit 1	Mus musculus (Mouse)		protein phosphatase regulator activity [GO:0019888]	protein phosphatase 4 complex [GO:0030289]	GO:0019888; GO:0030289
GN001438	GN001438.1	Q8TF05	42.8	313	502	950	1.19e-61	220	PP4R1_HUMAN	Serine/threonine-protein phosphatase 4 regulatory subunit 1	Homo sapiens (Human)	protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	protein phosphatase regulator activity [GO:0019888]	protein phosphatase 4 complex [GO:0030289]	GO:0006468; GO:0007165; GO:0019888; GO:0030289
GN001439	GN001439.1	Q8TF05	40.4	136	151	950	2.41e-25	103	PP4R1_HUMAN	Serine/threonine-protein phosphatase 4 regulatory subunit 1	Homo sapiens (Human)	protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]	protein phosphatase regulator activity [GO:0019888]	protein phosphatase 4 complex [GO:0030289]	GO:0006468; GO:0007165; GO:0019888; GO:0030289
GN001440	GN001440.1	P04069	47.5	297	388	303	1.72e-88	272	CBPB_ASTAS	Carboxypeptidase B (EC 3.4.17.2)	Astacus astacus (Noble crayfish) (Astacus fluviatilis)	proteolysis [GO:0006508]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0004181; GO:0005576; GO:0006508; GO:0008270
GN001442	GN001442.1	Q3UR97	35.1	225	320	363	1.38e-34	132	SNX21_MOUSE	Sorting nexin-21	Mus musculus (Mouse)	protein transport [GO:0015031]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	early endosome membrane [GO:0031901]	GO:0005546; GO:0015031; GO:0031901; GO:0032266; GO:0035091; GO:1901981
GN001443	GN001443.1	Q8N4N3	30.4	135	647	616	8.89e-10	65.5	KLH36_HUMAN	Kelch-like protein 36	Homo sapiens (Human)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	cullin family protein binding [GO:0097602]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]	GO:0016567; GO:0031463; GO:0043161; GO:0097602; GO:1990756
GN001444	GN001444.1	E1BBQ2	27.4	168	839	1216	2.96e-13	77.8	MGLYR_BOVIN	Metabotropic glycine receptor (mGlyR) (G protein-coupled receptor 158)	Bos taurus (Bovine)	cognition [GO:0050890]; G protein-coupled receptor signaling pathway [GO:0007186]; protein localization to plasma membrane [GO:0072659]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synapse organization [GO:0050807]	enzyme activator activity [GO:0008047]; G protein-coupled glycine receptor activity [GO:0160079]; transmembrane signaling receptor activity [GO:0004888]	nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	GO:0004888; GO:0005634; GO:0005886; GO:0007186; GO:0008047; GO:0008277; GO:0042734; GO:0045211; GO:0050807; GO:0050890; GO:0072659; GO:0160079
GN001445	GN001445.1	Q96DX4	49.4	83	137	576	1.88e-23	97.8	RSPRY_HUMAN	RING finger and SPRY domain-containing protein 1	Homo sapiens (Human)		ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	GO:0004842; GO:0005576; GO:0005737
GN001448	GN001448.1	Q8BVR6	60.5	296	354	576	1.20e-115	350	RSPRY_MOUSE	RING finger and SPRY domain-containing protein 1	Mus musculus (Mouse)		ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	GO:0004842; GO:0005576; GO:0005737
GN001449	GN001449.1	Q9DAR0	37.9	140	144	182	1.14e-21	88.6	CFA90_MOUSE	Cilia- and flagella-associated protein 90 (Y regulated sperm protein)	Mus musculus (Mouse)	flagellated sperm motility [GO:0030317]		axonemal B tubule inner sheath [GO:0160112]; axoneme [GO:0005930]; ciliary basal body [GO:0036064]; sperm flagellum [GO:0036126]	GO:0005930; GO:0030317; GO:0036064; GO:0036126; GO:0160112
GN001450	GN001450.1	Q21502	22.3	542	1264	870	2.09e-11	72.4	MEP1_CAEEL	MOG interacting and ectopic P-granules protein 1 (Nuclear zinc finger protein)	Caenorhabditis elegans	gonad development [GO:0008406]; nematode larval development [GO:0002119]; oocyte development [GO:0048599]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; vulval development [GO:0040025]	DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription factor activity [GO:0003700]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]	GO:0000976; GO:0002119; GO:0003700; GO:0003723; GO:0005634; GO:0006355; GO:0008406; GO:0010468; GO:0010628; GO:0017151; GO:0040025; GO:0042802; GO:0042826; GO:0048599
GN001452	GN001452.1	Q6TMK8	39.8	181	233	195	7.47e-36	128	PLD3B_CRIGR	PRELI domain containing protein 3B (BCR/ABL-regulated protein) (Protein slowmo homolog 2)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	intermembrane phospholipid transfer [GO:0120010]; mitochondrial membrane organization [GO:0007006]	phosphatidylserine transfer activity [GO:0140343]	mitochondrial intermembrane space [GO:0005758]	GO:0005758; GO:0007006; GO:0120010; GO:0140343
GN001453	GN001453.1	Q4G0P3	43.9	1913	1901	5121	0.0	1613	HYDIN_HUMAN	Axonemal central pair apparatus protein HYDIN (Hydrocephalus-inducing protein homolog)	Homo sapiens (Human)	axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]		axonemal central apparatus [GO:1990716]; axonemal central pair projection [GO:1990718]; axoneme [GO:0005930]; cilium [GO:0005929]; sperm flagellum [GO:0036126]	GO:0003341; GO:0005929; GO:0005930; GO:0036126; GO:1904158; GO:1990716; GO:1990718
GN001454	GN001454.1	Q4G0P3	51.7	60	61	5121	8.03e-15	69.7	HYDIN_HUMAN	Axonemal central pair apparatus protein HYDIN (Hydrocephalus-inducing protein homolog)	Homo sapiens (Human)	axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]		axonemal central apparatus [GO:1990716]; axonemal central pair projection [GO:1990718]; axoneme [GO:0005930]; cilium [GO:0005929]; sperm flagellum [GO:0036126]	GO:0003341; GO:0005929; GO:0005930; GO:0036126; GO:1904158; GO:1990716; GO:1990718
GN001455	GN001455.1	Q4G0P3	37.9	999	1031	5121	1.78e-137	462	HYDIN_HUMAN	Axonemal central pair apparatus protein HYDIN (Hydrocephalus-inducing protein homolog)	Homo sapiens (Human)	axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]		axonemal central apparatus [GO:1990716]; axonemal central pair projection [GO:1990718]; axoneme [GO:0005930]; cilium [GO:0005929]; sperm flagellum [GO:0036126]	GO:0003341; GO:0005929; GO:0005930; GO:0036126; GO:1904158; GO:1990716; GO:1990718
GN001456	GN001456.1	Q4G0P3	41.7	1827	1779	5121	0.0	1289	HYDIN_HUMAN	Axonemal central pair apparatus protein HYDIN (Hydrocephalus-inducing protein homolog)	Homo sapiens (Human)	axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]		axonemal central apparatus [GO:1990716]; axonemal central pair projection [GO:1990718]; axoneme [GO:0005930]; cilium [GO:0005929]; sperm flagellum [GO:0036126]	GO:0003341; GO:0005929; GO:0005930; GO:0036126; GO:1904158; GO:1990716; GO:1990718
GN001457	GN001457.1	Q4G0P3	59.9	324	350	5121	3.85e-126	402	HYDIN_HUMAN	Axonemal central pair apparatus protein HYDIN (Hydrocephalus-inducing protein homolog)	Homo sapiens (Human)	axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]		axonemal central apparatus [GO:1990716]; axonemal central pair projection [GO:1990718]; axoneme [GO:0005930]; cilium [GO:0005929]; sperm flagellum [GO:0036126]	GO:0003341; GO:0005929; GO:0005930; GO:0036126; GO:1904158; GO:1990716; GO:1990718
GN001460	GN001460.1	Q8L7W2	42.2	173	300	369	7.57e-46	161	NUDT8_ARATH	Nudix hydrolase 8 (AtNUDT8) (EC 3.6.1.-)	Arabidopsis thaliana (Mouse-ear cress)	response to wounding [GO:0009611]	hydrolase activity [GO:0016787]	cytosol [GO:0005829]	GO:0005829; GO:0009611; GO:0016787
GN001461	GN001461.1	Q80VP5	48.3	120	142	184	9.16e-27	101	MTRFR_MOUSE	Mitochondrial translation release factor in rescue	Mus musculus (Mouse)	rescue of stalled cytosolic ribosome [GO:0072344]; rescue of stalled mitochondrial ribosome [GO:7770016]	ribosomal large subunit binding [GO:0043023]; translation release factor activity, codon specific [GO:0016149]; tRNA binding [GO:0000049]	mitochondrion [GO:0005739]	GO:0000049; GO:0005739; GO:0016149; GO:0043023; GO:0072344; GO:7770016
GN001464	GN001464.1	P48612	71.5	362	373	395	9.93e-193	540	PELO_DROME	Protein pelota	Drosophila melanogaster (Fruit fly)	compound eye morphogenesis [GO:0001745]; female germ-line stem cell asymmetric division [GO:0048132]; germ-line stem cell population maintenance [GO:0030718]; male germ-line stem cell population maintenance [GO:0036098]; meiotic cell cycle [GO:0051321]; meiotic nuclear membrane disassembly [GO:0051078]; meiotic spindle organization [GO:0000212]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA catabolic process, non-stop decay [GO:0070481]; post-transcriptional gene silencing [GO:0016441]; rescue of stalled cytosolic ribosome [GO:0072344]; RNA surveillance [GO:0071025]; sperm individualization [GO:0007291]; spermatocyte division [GO:0048137]	stalled ribosome sensor activity [GO:0170011]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; Dom34-Hbs1 complex [GO:1990533]; nucleus [GO:0005634]	GO:0000212; GO:0001745; GO:0005634; GO:0005737; GO:0005829; GO:0007291; GO:0016441; GO:0022626; GO:0030718; GO:0036098; GO:0048132; GO:0048137; GO:0051078; GO:0051321; GO:0070481; GO:0070966; GO:0071025; GO:0072344; GO:0170011; GO:1990533
GN001465	GN001465.1	P10160	61.1	157	157	154	1.04e-63	195	IF5A1_RABIT	Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D)	Oryctolagus cuniculus (Rabbit)	positive regulation of translation [GO:0045727]; translational elongation [GO:0006414]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	GO:0003723; GO:0003746; GO:0005634; GO:0005737; GO:0005789; GO:0006414; GO:0043022; GO:0045727
GN001466	GN001466.1	Q95JN5	42.8	1224	1358	1226	7.06e-312	913	AT133_MACFA	Polyamine-transporting ATPase 13A3 (ATPase family homolog up-regulated in senescence cells 1) (Putrescine transporting ATPase) (EC 7.6.2.16)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	intracellular calcium ion homeostasis [GO:0006874]	ABC-type putrescine transporter activity [GO:0015594]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; P-type ion transporter activity [GO:0015662]; P-type transmembrane transporter activity [GO:0140358]	early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; recycling endosome membrane [GO:0055038]	GO:0005524; GO:0006874; GO:0015594; GO:0015662; GO:0016887; GO:0019829; GO:0031901; GO:0031902; GO:0055038; GO:0140358
GN001469	GN001469.1	Q95SX7	24.3	337	353	906	4.17e-17	86.3	RTBS_DROME	Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase)	Drosophila melanogaster (Fruit fly)	DNA transposition [GO:0006313]	RNA-directed DNA polymerase activity [GO:0003964]		GO:0003964; GO:0006313
GN001477	GN001477.1	Q28C22	49.5	109	105	349	3.28e-31	115	OGFD2_XENTR	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (EC 1.14.11.-)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]		GO:0005506; GO:0016705; GO:0031418
GN001478	GN001478.1	Q9Z0J4	50.5	1421	1460	1429	0.0	1343	NOS1_MOUSE	Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Nitric oxide synthase, brain) (bNOS) (Peptidyl-cysteine S-nitrosylase NOS1)	Mus musculus (Mouse)	behavioral response to cocaine [GO:0048148]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to growth factor stimulus [GO:0071363]; cellular response to mechanical stimulus [GO:0071260]; establishment of protein localization [GO:0045184]; L-arginine catabolic process [GO:0006527]; multicellular organismal response to stress [GO:0033555]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of hepatic stellate cell contraction [GO:0061875]; negative regulation of hydrolase activity [GO:0051346]; negative regulation of insulin secretion [GO:0046676]; negative regulation of iron ion transmembrane transport [GO:0034760]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of serotonin uptake [GO:0051612]; negative regulation of vasoconstriction [GO:0045906]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide-cGMP-mediated signaling [GO:0038060]; peptidyl-cysteine S-nitrosylation [GO:0018119]; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071879]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of sodium ion transmembrane transport [GO:1902307]; positive regulation of the force of heart contraction [GO:0098735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; regulation of postsynaptic membrane potential [GO:0060078]; regulation of sodium ion transport [GO:0002028]; response to estrogen [GO:0043627]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to peptide hormone [GO:0043434]; striated muscle contraction [GO:0006941]; synaptic signaling by nitric oxide [GO:0099163]; vasodilation [GO:0042311]; xenobiotic catabolic process [GO:0042178]	ATPase binding [GO:0051117]; cadmium ion binding [GO:0046870]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; NADP binding [GO:0050661]; NADPH binding [GO:0070402]; nitric-oxide synthase activity [GO:0004517]; peptidyl-cysteine S-nitrosylase activity [GO:0035605]; phosphoprotein binding [GO:0051219]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; scaffold protein binding [GO:0097110]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; zinc ion binding [GO:0008270]	azurophil granule [GO:0042582]; calyx of Held [GO:0044305]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic specialization, intracellular component [GO:0099091]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; secretory granule [GO:0030141]; synapse [GO:0045202]; T-tubule [GO:0030315]; Z disc [GO:0030018]	GO:0001666; GO:0001917; GO:0002028; GO:0004517; GO:0005516; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005741; GO:0005829; GO:0005856; GO:0005886; GO:0006527; GO:0006809; GO:0006941; GO:0008270; GO:0008285; GO:0009408; GO:0009725; GO:0010181; GO:0014069; GO:0016529; GO:0017080; GO:0018119; GO:0019899; GO:0020037; GO:0030018; GO:0030141; GO:0030315; GO:0030425; GO:0031965; GO:0032496; GO:0032991; GO:0033017; GO:0033555; GO:0034760; GO:0035605; GO:0038060; GO:0042178; GO:0042311; GO:0042383; GO:0042582; GO:0042802; GO:0043066; GO:0043197; GO:0043267; GO:0043434; GO:0043524; GO:0043525; GO:0043627; GO:0044305; GO:0044325; GO:0045121; GO:0045184; GO:0045202; GO:0045776; GO:0045893; GO:0045906; GO:0045944; GO:0046676; GO:0046870; GO:0048148; GO:0048306; GO:0048471; GO:0050660; GO:0050661; GO:0050767; GO:0051117; GO:0051219; GO:0051346; GO:0051481; GO:0051612; GO:0051926; GO:0060078; GO:0061629; GO:0061875; GO:0070402; GO:0071260; GO:0071363; GO:0071872; GO:0071879; GO:0071944; GO:0097110; GO:0098735; GO:0098978; GO:0099091; GO:0099092; GO:0099163; GO:0106071; GO:1900273; GO:1902307
GN001482	GN001482.1	Q28141	60.4	1182	1253	1287	0.0	1387	DHX9_BOVIN	ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (Nuclear DNA helicase II) (NDH II)	Bos taurus (Bovine)	alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; chromatin organization [GO:0006325]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cytoplasmic translation [GO:2000765]; regulation of mRNA processing [GO:0050684]; RISC complex assembly [GO:0070922]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' DNA/RNA helicase activity [GO:0033679]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; G-quadruplex unwinding activity [GO:0160225]; importin-alpha family protein binding [GO:0061676]; mRNA binding [GO:0003729]; nucleoside triphosphate diphosphatase activity [GO:0047429]; promoter-specific chromatin binding [GO:1990841]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase binding [GO:0070063]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; transcription coactivator activity [GO:0003713]; triplex DNA binding [GO:0045142]	actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; ribonucleoprotein complex [GO:1990904]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]	GO:0000380; GO:0000978; GO:0003677; GO:0003688; GO:0003690; GO:0003697; GO:0003713; GO:0003723; GO:0003724; GO:0003725; GO:0003727; GO:0003729; GO:0005524; GO:0005634; GO:0005654; GO:0005726; GO:0005730; GO:0005737; GO:0005813; GO:0006325; GO:0015629; GO:0016442; GO:0016604; GO:0016887; GO:0017111; GO:0031490; GO:0032727; GO:0032728; GO:0032755; GO:0032760; GO:0033679; GO:0034458; GO:0035195; GO:0035613; GO:0036464; GO:0043138; GO:0045142; GO:0045739; GO:0045740; GO:0045944; GO:0046833; GO:0047429; GO:0048146; GO:0050684; GO:0060760; GO:0061676; GO:0070063; GO:0070578; GO:0070922; GO:0070937; GO:0071360; GO:0097165; GO:0160225; GO:1905172; GO:1990518; GO:1990825; GO:1990841; GO:1990904; GO:2000765; GO:2000767
GN001483	GN001483.1	Q9V410	70.1	308	310	975	4.74e-162	479	LZTR1_DROME	Leucine-zipper-like transcriptional regulator 1 homolog	Drosophila melanogaster (Fruit fly)	gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of glycogen metabolic process [GO:0070875]; protein ubiquitination [GO:0016567]; sleep [GO:0030431]; triglyceride homeostasis [GO:0070328]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; Golgi apparatus [GO:0005794]; recycling endosome membrane [GO:0055038]	GO:0005794; GO:0007214; GO:0016567; GO:0030431; GO:0031463; GO:0046580; GO:0055038; GO:0070328; GO:0070875; GO:1990756
GN001484	GN001484.1	Q924H5	53.1	305	321	366	3.95e-106	317	RA51C_MOUSE	DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2)	Mus musculus (Mouse)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; female meiosis sister chromatid cohesion [GO:0007066]; male meiosis I [GO:0007141]; meiotic DNA recombinase assembly [GO:0000707]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; replication fork processing [GO:0031297]; spermatogenesis [GO:0007283]; supramolecular fiber organization [GO:0097435]; telomere maintenance via recombination [GO:0000722]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; crossover junction DNA endonuclease activity [GO:0008821]; four-way junction DNA binding [GO:0000400]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Holliday junction resolvase complex [GO:0048476]; mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; Rad51C-XRCC3 complex [GO:0033065]; replication fork [GO:0005657]	GO:0000400; GO:0000707; GO:0000722; GO:0000724; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005737; GO:0005739; GO:0005829; GO:0006281; GO:0006310; GO:0007066; GO:0007131; GO:0007141; GO:0007283; GO:0008821; GO:0010971; GO:0030054; GO:0031297; GO:0033063; GO:0033065; GO:0043596; GO:0048471; GO:0048476; GO:0097435; GO:0140664
GN001485	GN001485.1	Q6NZQ0	39.3	206	221	333	2.98e-38	138	CF119_MOUSE	Cilia- and flagella-associated protein 119 (Coiled-coil domain-containing protein 189)	Mus musculus (Mouse)	gene expression [GO:0010467]; single fertilization [GO:0007338]; sperm flagellum assembly [GO:0120316]		acrosomal vesicle [GO:0001669]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; radial spoke [GO:0001534]; sperm principal piece [GO:0097228]	GO:0001534; GO:0001669; GO:0005737; GO:0005930; GO:0007338; GO:0010467; GO:0097228; GO:0120316
GN001494	GN001494.1	Q86U38	24.7	576	583	636	2.80e-44	170	NOP9_HUMAN	Nucleolar protein 9	Homo sapiens (Human)	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; ribosomal small subunit export from nucleus [GO:0000056]	RNA binding [GO:0003723]	90S preribosome [GO:0030686]; preribosome, small subunit precursor [GO:0030688]	GO:0000056; GO:0000447; GO:0000472; GO:0000480; GO:0003723; GO:0030686; GO:0030688
GN001499	GN001499.1	D3YZI9	32.2	121	251	523	6.73e-09	59.3	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN001500	GN001500.1	Q8AX98	71.8	227	455	463	1.59e-111	339	TBX1A_XENLA	T-box transcription factor TBX1-A (T-box protein 1-A)	Xenopus laevis (African clawed frog)	cell fate specification [GO:0001708]; cellular response to retinoic acid [GO:0071300]; ectodermal placode formation [GO:0060788]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of developmental process [GO:0050793]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001708; GO:0003700; GO:0005634; GO:0006357; GO:0045944; GO:0050793; GO:0060788; GO:0071300
GN001501	GN001501.1	P22059	51.7	779	770	807	1.72e-258	739	OSBP1_HUMAN	Oxysterol-binding protein 1	Homo sapiens (Human)	bile acid biosynthetic process [GO:0006699]; ceramide transport [GO:0035627]; intracellular cholesterol transport [GO:0032367]; lipid transport [GO:0006869]; phospholipid transport [GO:0015914]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of secretory granule organization [GO:1904411]; sphingomyelin biosynthetic process [GO:0006686]; sterol transport [GO:0015918]	lipid transfer activity [GO:0120013]; oxysterol binding [GO:0008142]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-4-phosphate-cholesterol exchange activity [GO:0160291]; protein domain specific binding [GO:0019904]; sterol transfer activity [GO:0120015]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-trans-Golgi network membrane contact site [GO:0160258]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0005737; GO:0005789; GO:0005794; GO:0005802; GO:0005829; GO:0005886; GO:0006686; GO:0006699; GO:0006869; GO:0008142; GO:0015914; GO:0015918; GO:0016020; GO:0019904; GO:0032367; GO:0035627; GO:0035774; GO:0048471; GO:0070273; GO:0097038; GO:0120013; GO:0120015; GO:0160258; GO:0160291; GO:1904411
GN001506	GN001506.1	Q6P9S0	53.1	335	920	715	5.69e-97	323	MTSS2_MOUSE	Protein MTSS 2 (MTSS1-like protein)	Mus musculus (Mouse)	activation of GTPase activity [GO:0090630]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; lamellipodium organization [GO:0097581]; membrane organization [GO:0061024]; plasma membrane organization [GO:0007009]	actin binding [GO:0003779]; actin monomer binding [GO:0003785]; GTPase activator activity [GO:0005096]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	GO:0001726; GO:0003779; GO:0003785; GO:0005096; GO:0005543; GO:0005546; GO:0005737; GO:0005886; GO:0005925; GO:0007009; GO:0015629; GO:0030027; GO:0030864; GO:0031267; GO:0032587; GO:0036120; GO:0061024; GO:0090630; GO:0097581
GN001507	GN001507.1	Q9NTZ6	22.9	402	1497	932	9.50e-21	103	RBM12_HUMAN	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN)	Homo sapiens (Human)	regulation of RNA splicing [GO:0043484]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005654; GO:0043484; GO:1990904
GN001508	GN001508.1	Q8BR76	29.9	134	175	992	2.37e-17	82.0	MKS3_MOUSE	Meckelin (Meckel syndrome type 3 protein homolog) (Transmembrane protein 67)	Mus musculus (Mouse)	branching morphogenesis of an epithelial tube [GO:0048754]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; ERAD pathway [GO:0036503]; head development [GO:0060322]; heart development [GO:0007507]; kidney development [GO:0001822]; negative regulation of centrosome duplication [GO:0010826]; non-canonical Wnt signaling pathway [GO:0035567]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of non-motile cilium assembly [GO:1902857]	filamin binding [GO:0031005]; misfolded protein binding [GO:0051787]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; MKS complex [GO:0036038]; plasma membrane [GO:0005886]	GO:0001822; GO:0005789; GO:0005813; GO:0005886; GO:0005930; GO:0007368; GO:0007507; GO:0010826; GO:0030659; GO:0031005; GO:0035567; GO:0035845; GO:0035869; GO:0036038; GO:0036503; GO:0048754; GO:0051787; GO:0060170; GO:0060271; GO:0060322; GO:0060441; GO:1902857; GO:1904294
GN001510	GN001510.1	P0C152	31.9	160	157	992	3.31e-19	86.7	MKS3_RAT	Meckelin (Meckel syndrome type 3 protein homolog) (Transmembrane protein 67)	Rattus norvegicus (Rat)	branching morphogenesis of an epithelial tube [GO:0048754]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; ERAD pathway [GO:0036503]; head development [GO:0060322]; heart development [GO:0007507]; kidney development [GO:0001822]; negative regulation of centrosome duplication [GO:0010826]; non-canonical Wnt signaling pathway [GO:0035567]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of non-motile cilium assembly [GO:1902857]	filamin binding [GO:0031005]; misfolded protein binding [GO:0051787]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; MKS complex [GO:0036038]; plasma membrane [GO:0005886]	GO:0001822; GO:0005789; GO:0005813; GO:0005886; GO:0005930; GO:0007368; GO:0007507; GO:0010826; GO:0030659; GO:0031005; GO:0035567; GO:0035845; GO:0035869; GO:0036038; GO:0036503; GO:0048754; GO:0051787; GO:0060170; GO:0060271; GO:0060322; GO:0060441; GO:1902857; GO:1904294
GN001511	GN001511.1	P0C152	43.8	422	424	992	2.37e-106	339	MKS3_RAT	Meckelin (Meckel syndrome type 3 protein homolog) (Transmembrane protein 67)	Rattus norvegicus (Rat)	branching morphogenesis of an epithelial tube [GO:0048754]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; ERAD pathway [GO:0036503]; head development [GO:0060322]; heart development [GO:0007507]; kidney development [GO:0001822]; negative regulation of centrosome duplication [GO:0010826]; non-canonical Wnt signaling pathway [GO:0035567]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of non-motile cilium assembly [GO:1902857]	filamin binding [GO:0031005]; misfolded protein binding [GO:0051787]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; MKS complex [GO:0036038]; plasma membrane [GO:0005886]	GO:0001822; GO:0005789; GO:0005813; GO:0005886; GO:0005930; GO:0007368; GO:0007507; GO:0010826; GO:0030659; GO:0031005; GO:0035567; GO:0035845; GO:0035869; GO:0036038; GO:0036503; GO:0048754; GO:0051787; GO:0060170; GO:0060271; GO:0060322; GO:0060441; GO:1902857; GO:1904294
GN001512	GN001512.1	Q8BR76	48.2	137	161	992	3.70e-37	138	MKS3_MOUSE	Meckelin (Meckel syndrome type 3 protein homolog) (Transmembrane protein 67)	Mus musculus (Mouse)	branching morphogenesis of an epithelial tube [GO:0048754]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; ERAD pathway [GO:0036503]; head development [GO:0060322]; heart development [GO:0007507]; kidney development [GO:0001822]; negative regulation of centrosome duplication [GO:0010826]; non-canonical Wnt signaling pathway [GO:0035567]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of non-motile cilium assembly [GO:1902857]	filamin binding [GO:0031005]; misfolded protein binding [GO:0051787]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; MKS complex [GO:0036038]; plasma membrane [GO:0005886]	GO:0001822; GO:0005789; GO:0005813; GO:0005886; GO:0005930; GO:0007368; GO:0007507; GO:0010826; GO:0030659; GO:0031005; GO:0035567; GO:0035845; GO:0035869; GO:0036038; GO:0036503; GO:0048754; GO:0051787; GO:0060170; GO:0060271; GO:0060322; GO:0060441; GO:1902857; GO:1904294
GN001522	GN001522.1	Q9Y2C9	26.9	398	398	796	8.18e-33	134	TLR6_HUMAN	Toll-like receptor 6 (CD antigen CD286)	Homo sapiens (Human)	activation of NF-kappaB-inducing kinase activity [GO:0007250]; antibacterial innate immune response [GO:0140367]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide metabolic process [GO:0046209]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macrophage activation [GO:0043032]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	amyloid-beta binding [GO:0001540]; diacyl lipopeptide binding [GO:0042498]; identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	GO:0001540; GO:0001774; GO:0002224; GO:0002755; GO:0004888; GO:0005102; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0007165; GO:0007250; GO:0010628; GO:0030670; GO:0031663; GO:0032717; GO:0032720; GO:0032731; GO:0032755; GO:0034136; GO:0035355; GO:0035663; GO:0035666; GO:0038023; GO:0038124; GO:0042496; GO:0042498; GO:0042742; GO:0042802; GO:0043032; GO:0043123; GO:0043235; GO:0043507; GO:0045087; GO:0045121; GO:0045429; GO:0046209; GO:0046982; GO:0050729; GO:0071723; GO:0071726; GO:0140052; GO:0140367; GO:1900017; GO:1900227; GO:1903428; GO:1904646; GO:2001238
GN001524	GN001524.1	Q9DBM1	42.6	745	1005	930	1.98e-163	507	GPTC1_MOUSE	G patch domain-containing protein 1	Mus musculus (Mouse)	mRNA processing [GO:0006397]	nucleic acid binding [GO:0003676]	catalytic step 2 spliceosome [GO:0071013]	GO:0003676; GO:0006397; GO:0071013
GN001525	GN001525.1	Q8HXQ5	45.8	1590	1670	1530	0.0	1287	MRP1_BOVIN	ATP-binding cassette sub-family C member 1 (EC 7.6.2.-) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) (Multidrug resistance-associated protein 1) (EC 7.6.2.2)	Bos taurus (Bovine)	cyclic nucleotide transport [GO:0070729]; glutathione transmembrane transport [GO:0034775]; leukotriene transport [GO:0071716]; positive regulation of inflammatory response [GO:0050729]; response to xenobiotic stimulus [GO:0009410]; xenobiotic transport [GO:0042908]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; carboxylic acid transmembrane transporter activity [GO:0046943]; glutathione transmembrane transporter activity [GO:0034634]; xenobiotic transmembrane transporter activity [GO:0042910]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005524; GO:0005886; GO:0008559; GO:0009410; GO:0015431; GO:0016323; GO:0016887; GO:0034634; GO:0034775; GO:0042908; GO:0042910; GO:0046943; GO:0050729; GO:0070729; GO:0071716; GO:0140359
GN001528	GN001528.1	Q24JY1	72.9	118	147	156	1.39e-47	154	RL23A_BOVIN	Large ribosomal subunit protein uL23 (60S ribosomal protein L23a)	Bos taurus (Bovine)	translation [GO:0006412]	rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; TORC2 complex binding [GO:1904841]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]; nucleus [GO:0005634]	GO:0003735; GO:0005634; GO:0005737; GO:0006412; GO:0019843; GO:0022625; GO:1904841
GN001529	GN001529.1	Q06AU4	51.4	255	264	259	8.42e-88	264	RAB34_PIG	Ras-related protein Rab-34 (EC 3.6.5.2)	Sus scrofa (Pig)	cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; Golgi to plasma membrane protein transport [GO:0043001]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; positive regulation of smoothened signaling pathway [GO:0045880]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]	GO:0003924; GO:0003925; GO:0005525; GO:0005737; GO:0005794; GO:0005813; GO:0005814; GO:0005929; GO:0030670; GO:0031985; GO:0043001; GO:0045335; GO:0045880; GO:0060271; GO:0061824; GO:0090382; GO:0090385
GN001530	GN001530.1	Q503L9	42.2	419	416	418	3.12e-106	323	NXN_DANRE	Nucleoredoxin (EC 1.8.1.8)	Danio rerio (Zebrafish) (Brachydanio rerio)	circulatory system development [GO:0072359]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]	thioredoxin-disulfide reductase (NADPH) activity [GO:0004791]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004791; GO:0005634; GO:0005829; GO:0030178; GO:0031397; GO:0072359
GN001532	GN001532.1	O23299	31.7	218	223	240	4.31e-24	99.0	ECI2_ARATH	Enoyl-CoA delta isomerase 2, peroxisomal (EC 5.3.3.8) (Delta(3),Delta(2)-enoyl CoA isomerase 2) (AtECI2) (Indole-3-butyric acid response 10)	Arabidopsis thaliana (Mouse-ear cress)	fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062]; indolebutyric acid metabolic process [GO:0080024]; response to indolebutyric acid [GO:0080026]; root hair elongation [GO:0048767]	delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]	cytoplasm [GO:0005737]; peroxisome [GO:0005777]	GO:0004165; GO:0005737; GO:0005777; GO:0006635; GO:0009062; GO:0048767; GO:0080024; GO:0080026
GN001533	GN001533.1	O23299	34.3	169	185	240	6.07e-23	94.7	ECI2_ARATH	Enoyl-CoA delta isomerase 2, peroxisomal (EC 5.3.3.8) (Delta(3),Delta(2)-enoyl CoA isomerase 2) (AtECI2) (Indole-3-butyric acid response 10)	Arabidopsis thaliana (Mouse-ear cress)	fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062]; indolebutyric acid metabolic process [GO:0080024]; response to indolebutyric acid [GO:0080026]; root hair elongation [GO:0048767]	delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]	cytoplasm [GO:0005737]; peroxisome [GO:0005777]	GO:0004165; GO:0005737; GO:0005777; GO:0006635; GO:0009062; GO:0048767; GO:0080024; GO:0080026
GN001549	GN001549.1	Q5AXT5	27.0	429	651	745	2.12e-29	127	PIF1_EMENI	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]	GO:0000723; GO:0003697; GO:0005524; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0043139; GO:0043596; GO:0071932
GN001563	GN001563.1	Q9XWN7	37.8	299	315	338	1.89e-51	176	NSH1_CAEEL	Nucleoside hydrolase (EC 3.2.2.-) (EC 3.2.2.1) (EC 3.2.2.2) (EC 3.2.2.3) (EC 3.2.2.7) (EC 3.2.2.8)	Caenorhabditis elegans	purine nucleoside catabolic process [GO:0006152]	adenosine nucleosidase activity [GO:0047622]; calcium ion binding [GO:0005509]; inosine nucleosidase activity [GO:0047724]; purine nucleosidase activity [GO:0008477]; ribosylpyrimidine nucleosidase activity [GO:0050263]; uridine nucleosidase activity [GO:0045437]; xanthosine nucleotidase activity [GO:0072585]		GO:0005509; GO:0006152; GO:0008477; GO:0045437; GO:0047622; GO:0047724; GO:0050263; GO:0072585
GN001570	GN001570.1	O15943	34.4	2903	2928	3097	0.0	1266	CADN_DROME	Neural-cadherin (Cadherin-N) (dN-cadherin)	Drosophila melanogaster (Fruit fly)	axon extension [GO:0048675]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; axonal fasciculation [GO:0007413]; calcium-dependent cell-cell adhesion [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell-cell adhesion [GO:0007156]; negative regulation of dendrite morphogenesis [GO:0050774]; ommatidial rotation [GO:0016318]; R7 cell development [GO:0045467]; R8 cell development [GO:0045463]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of dendrite morphogenesis [GO:0048814]; retinal ganglion cell axon guidance [GO:0031290]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005911; GO:0007156; GO:0007411; GO:0007412; GO:0007413; GO:0016020; GO:0016318; GO:0016339; GO:0030424; GO:0030425; GO:0031290; GO:0042803; GO:0044331; GO:0045296; GO:0045463; GO:0045467; GO:0048675; GO:0048814; GO:0048841; GO:0048846; GO:0050774; GO:0098609
GN001571	GN001571.1	P70623	36.1	83	206	132	1.01e-10	60.5	FABP4_RAT	Fatty acid-binding protein, adipocyte (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)	Rattus norvegicus (Rat)	brown fat cell differentiation [GO:0050873]; cellular response to lithium ion [GO:0071285]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol homeostasis [GO:0042632]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; lipid droplet formation [GO:0140042]; long-chain fatty acid transport [GO:0015909]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of fat cell proliferation [GO:0070346]; positive regulation of inflammatory response [GO:0050729]; response to bacterium [GO:0009617]; response to glucocorticoid [GO:0051384]; response to gravity [GO:0009629]; response to xenobiotic stimulus [GO:0009410]; triglyceride catabolic process [GO:0019433]; white fat cell differentiation [GO:0050872]	fatty acid binding [GO:0005504]; hormone receptor binding [GO:0051427]; lipase activator activity [GO:0060229]; long-chain fatty acid binding [GO:0036041]; long-chain fatty acid transmembrane transporter activity [GO:0005324]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; nucleus [GO:0005634]	GO:0005324; GO:0005504; GO:0005634; GO:0005737; GO:0005811; GO:0005829; GO:0006469; GO:0006631; GO:0008284; GO:0009410; GO:0009617; GO:0009629; GO:0015908; GO:0015909; GO:0019433; GO:0036041; GO:0042632; GO:0045892; GO:0050729; GO:0050872; GO:0050873; GO:0051384; GO:0051427; GO:0060229; GO:0070346; GO:0071285; GO:0071356; GO:0120162; GO:0140042
GN001572	GN001572.1	Q29486	52.5	99	105	524	6.61e-23	94.7	PPBT_FELCA	Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1)	Felis catus (Cat) (Felis silvestris catus)	bone mineralization [GO:0030282]; dephosphorylation [GO:0016311]; positive regulation of cold-induced thermogenesis [GO:0120162]	5'-nucleotidase activity [GO:0008253]; ADP phosphatase activity [GO:0043262]; alkaline phosphatase activity [GO:0004035]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; inorganic diphosphate phosphatase activity [GO:0004427]; phosphoamidase activity [GO:0050187]; phosphoethanolamine phosphatase activity [GO:0052732]; pyridoxal phosphatase activity [GO:0033883]; pyrophosphatase activity [GO:0016462]	mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	GO:0004035; GO:0004427; GO:0005509; GO:0005758; GO:0005886; GO:0008253; GO:0016311; GO:0016462; GO:0016887; GO:0030282; GO:0031966; GO:0033883; GO:0043262; GO:0050187; GO:0052732; GO:0120162
GN001575	GN001575.1	Q9I7F7	54.3	554	1554	1337	2.49e-170	552	ACKL_DROME	Activated Cdc42 kinase-like (EC 2.7.10.2) (Tyrosine-protein kinase PR2)	Drosophila melanogaster (Fruit fly)	dorsal closure, amnioserosa morphology change [GO:0046664]; head involution [GO:0008258]; myosin filament assembly [GO:0031034]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]	plasma membrane [GO:0005886]	GO:0004713; GO:0004715; GO:0005524; GO:0005886; GO:0006468; GO:0008258; GO:0031034; GO:0046664
GN001576	GN001576.1	Q9ULI1	30.3	634	1396	1742	4.60e-70	263	NWD2_HUMAN	NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239)	Homo sapiens (Human)			synapse [GO:0045202]	GO:0045202
GN001577	GN001577.1	A6H603	40.9	127	185	1563	1.75e-23	100	NWD1_MOUSE	NACHT domain- and WD repeat-containing protein 1	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; positive regulation of gene expression [GO:0010628]		cytosol [GO:0005829]; nucleolus [GO:0005730]	GO:0005730; GO:0005829; GO:0010628; GO:0035556
GN001579	GN001579.1	Q07912	59.2	498	1114	1038	1.30e-184	569	ACK1_HUMAN	Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)	Homo sapiens (Human)	cell surface receptor signaling pathway [GO:0007166]; phosphorylation [GO:0016310]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of clathrin-dependent endocytosis [GO:2000369]; small GTPase-mediated signal transduction [GO:0007264]	ATP binding [GO:0005524]; epidermal growth factor receptor binding [GO:0005154]; GTPase inhibitor activity [GO:0005095]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]	adherens junction [GO:0005912]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome [GO:0005768]; Grb2-EGFR complex [GO:0070436]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0004674; GO:0004712; GO:0004713; GO:0004715; GO:0005095; GO:0005154; GO:0005524; GO:0005634; GO:0005737; GO:0005768; GO:0005829; GO:0005886; GO:0005905; GO:0005912; GO:0007166; GO:0007264; GO:0016020; GO:0016310; GO:0030136; GO:0030659; GO:0031625; GO:0042802; GO:0048471; GO:0050699; GO:0050731; GO:0070436; GO:0097268; GO:0106310; GO:2000369
GN001580	GN001580.1	Q8K385	32.1	184	279	592	1.07e-16	83.2	FRRS1_MOUSE	Ferric reductase 1 (EC 1.-.-.-) (Ferric-chelate reductase 1) (Stromal cell-derived receptor 2) (SDR-2)	Mus musculus (Mouse)	intracellular iron ion homeostasis [GO:0006879]	oxidoreductase activity, acting on metal ions [GO:0016722]	membrane [GO:0016020]	GO:0006879; GO:0016020; GO:0016722
GN001586	GN001586.1	Q8C6K9	30.5	407	409	2265	2.45e-39	154	CO6A6_MOUSE	Collagen alpha-6(VI) chain	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]		collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005589; GO:0030198; GO:0031012
GN001588	GN001588.1	A2AX52	27.3	352	366	2309	4.78e-32	131	CO6A4_MOUSE	Collagen alpha-4(VI) chain	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]	collagen binding [GO:0005518]	collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991]	GO:0005518; GO:0005576; GO:0005589; GO:0030198; GO:0031012; GO:0032991
GN001592	GN001592.1	Q5BKL0	68.8	382	1027	394	1.02e-186	549	HPPD_XENTR	4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	L-phenylalanine catabolic process [GO:0006559]; L-tyrosine catabolic process [GO:0006572]	4-hydroxyphenylpyruvate dioxygenase activity [GO:0003868]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	GO:0000139; GO:0003868; GO:0005737; GO:0005789; GO:0006559; GO:0006572; GO:0042803
GN001594	GN001594.1	Q6XV80	36.2	301	937	763	9.09e-56	210	NBN_XENLA	Nibrin (Nijmegen breakage syndrome protein 1 homolog) (xNBS1)	Xenopus laevis (African clawed frog)	DNA double-strand break processing [GO:0000729]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; isotype switching [GO:0045190]; metaphase chromosome alignment [GO:0051310]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to site of double-strand break [GO:1990166]; R-loop processing [GO:0062176]; regulation of fibroblast proliferation [GO:0048145]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]	chromatin-protein adaptor activity [GO:0140463]; damaged DNA binding [GO:0003684]; DNA-binding transcription factor binding [GO:0140297]; phosphorylation-dependent protein binding [GO:0140031]; protein serine/threonine kinase activator activity [GO:0043539]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; Mre11 complex [GO:0030870]; nuclear inclusion body [GO:0042405]; nucleus [GO:0005634]; PML body [GO:0016605]; site of double-strand break [GO:0035861]	GO:0000723; GO:0000724; GO:0000729; GO:0000781; GO:0003684; GO:0005634; GO:0005694; GO:0006302; GO:0007095; GO:0016605; GO:0030870; GO:0031848; GO:0035861; GO:0042405; GO:0043247; GO:0043539; GO:0045190; GO:0048145; GO:0051310; GO:0062176; GO:0110025; GO:0140031; GO:0140297; GO:0140463; GO:1990166
GN001596	GN001596.1	A6QPU5	48.7	392	385	651	3.80e-121	367	SYDM_BOVIN	Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)	Bos taurus (Bovine)	aspartyl-tRNA aminoacylation [GO:0006422]; mitochondrial asparaginyl-tRNA aminoacylation [GO:0070145]	aspartate-tRNA ligase activity [GO:0004815]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]	mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	GO:0003676; GO:0004815; GO:0005524; GO:0005739; GO:0005759; GO:0006422; GO:0031966; GO:0070145
GN001597	GN001597.1	O43586	30.2	281	419	416	2.38e-30	124	PPIP1_HUMAN	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)	Homo sapiens (Human)	cell adhesion [GO:0007155]; signal transduction [GO:0007165]	identical protein binding [GO:0042802]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931]	GO:0001931; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0007155; GO:0007165; GO:0016020; GO:0030027; GO:0032154; GO:0042802; GO:0048471
GN001598	GN001598.1	M9PH32	24.1	328	744	1206	2.67e-19	97.1	MEI26_DROME	Protein meiotic P26	Drosophila melanogaster (Fruit fly)	protein ubiquitination [GO:0016567]	ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]	GO:0004842; GO:0005737; GO:0008270; GO:0016567; GO:0036464
GN001600	GN001600.1	Q86YT5	42.7	539	570	568	9.22e-132	399	S13A5_HUMAN	Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5)	Homo sapiens (Human)	alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; citrate transport [GO:0015746]; fumarate transport [GO:0015741]; oxaloacetate transport [GO:0015729]; succinate transport [GO:0015744]; transmembrane transport [GO:0055085]	citrate transmembrane transporter activity [GO:0015137]; identical protein binding [GO:0042802]; organic acid:sodium symporter activity [GO:0005343]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]	plasma membrane [GO:0005886]	GO:0005343; GO:0005886; GO:0015137; GO:0015141; GO:0015729; GO:0015741; GO:0015742; GO:0015744; GO:0015746; GO:0017153; GO:0042802; GO:0055085; GO:0071285
GN001601	GN001601.1	P56839	89.0	291	325	295	9.86e-189	524	PEPM_MYTED	Phosphoenolpyruvate phosphomutase (PEP mutase) (PEP phosphomutase) (Phosphoenolpyruvate mutase) (EC 5.4.2.9)	Mytilus edulis (Blue mussel)	organic phosphonate biosynthetic process [GO:0032923]	phosphoenolpyruvate mutase activity [GO:0050188]		GO:0032923; GO:0050188
GN001602	GN001602.1	Q7PPA5	75.2	1004	1046	1018	0.0	1486	ATC1_ANOGA	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (EC 7.2.2.10) (Calcium pump) (Sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase)	Anopheles gambiae (African malaria mosquito)	calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388]	sarcoplasmic reticulum membrane [GO:0033017]	GO:0005388; GO:0005524; GO:0006874; GO:0016887; GO:0033017; GO:0070588
GN001604	GN001604.1	P70545	38.6	158	167	587	2.04e-14	73.2	S13A2_RAT	Solute carrier family 13 member 2 (Intestinal sodium/dicarboxylate cotransporter) (Na(+)/dicarboxylate cotransporter 1) (NaDC-1)	Rattus norvegicus (Rat)	alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; fumarate transport [GO:0015741]; succinate transmembrane transport [GO:0071422]	alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; citrate transmembrane transporter activity [GO:0015137]; fumarate transmembrane transporter activity [GO:0015138]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0005886; GO:0015137; GO:0015138; GO:0015139; GO:0015141; GO:0015741; GO:0015742; GO:0016324; GO:0017153; GO:0071285; GO:0071422
GN001605	GN001605.1	P56839	89.0	291	325	295	9.86e-189	524	PEPM_MYTED	Phosphoenolpyruvate phosphomutase (PEP mutase) (PEP phosphomutase) (Phosphoenolpyruvate mutase) (EC 5.4.2.9)	Mytilus edulis (Blue mussel)	organic phosphonate biosynthetic process [GO:0032923]	phosphoenolpyruvate mutase activity [GO:0050188]		GO:0032923; GO:0050188
GN001606	GN001606.1	Q7PPA5	75.6	998	1040	1018	0.0	1491	ATC1_ANOGA	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (EC 7.2.2.10) (Calcium pump) (Sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase)	Anopheles gambiae (African malaria mosquito)	calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; P-type calcium transporter activity [GO:0005388]	sarcoplasmic reticulum membrane [GO:0033017]	GO:0005388; GO:0005524; GO:0006874; GO:0016887; GO:0033017; GO:0070588
GN001607	GN001607.1	Q3UPR9	52.7	55	136	264	1.92e-12	65.5	SBSPO_MOUSE	Somatomedin-B and thrombospondin type-1 domain-containing protein (RPE-spondin)	Mus musculus (Mouse)			non-collagenous component of basement membrane [GO:0140144]	GO:0140144
GN001609	GN001609.1	P99027	68.1	72	112	115	1.13e-26	98.2	RLA2_MOUSE	Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2)	Mus musculus (Mouse)	cytoplasmic translation [GO:0002181]; cytoplasmic translational elongation [GO:0002182]; negative regulation of myoblast fusion [GO:1901740]; spermatogenesis [GO:0007283]; striated muscle contraction [GO:0006941]; translation at postsynapse [GO:0140242]; translation at presynapse [GO:0140236]	iron ion binding [GO:0005506]; ribonucleoprotein complex binding [GO:0043021]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; postsynapse [GO:0098794]; presynapse [GO:0098793]; ribosome [GO:0005840]; synapse [GO:0045202]	GO:0002181; GO:0002182; GO:0003735; GO:0005506; GO:0005737; GO:0005829; GO:0005840; GO:0006941; GO:0007283; GO:0022625; GO:0043021; GO:0045202; GO:0098793; GO:0098794; GO:0140236; GO:0140242; GO:1901740
GN001610	GN001610.1	P93159	25.6	348	343	668	3.45e-15	80.1	ENG1_SOYBN	Glucan endo-1,3-beta-D-glucosidase (Endo-1,3-beta-glucanase) (EC 3.2.1.39) (Beta-glucan elicitor-binding protein) (GEBP) (Laminarinase)	Glycine max (Soybean) (Glycine hispida)	cell wall polysaccharide catabolic process [GO:0044347]; detection of symbiotic fungus [GO:0009603]	glucan endo-1,3-beta-D-glucosidase activity [GO:0042973]; polysaccharide binding [GO:0030247]	plant-type cell wall [GO:0009505]	GO:0009505; GO:0009603; GO:0030247; GO:0042973; GO:0044347
GN001612	GN001612.1	Q9Z265	47.1	471	480	546	5.13e-154	452	CHK2_MOUSE	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Checkpoint kinase 2)	Mus musculus (Mouse)	apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; cellular response to gamma radiation [GO:0071480]; cellular response to stress [GO:0033554]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; double-strand break repair [GO:0006302]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic DNA damage checkpoint signaling [GO:0044773]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; mitotic spindle assembly [GO:0090307]; negative regulation of DNA damage checkpoint [GO:2000002]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of anoikis [GO:2000210]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein K63-linked ubiquitination [GO:0070534]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of autophagosome assembly [GO:2000785]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein catabolic process [GO:0042176]; response to gamma radiation [GO:0010332]; response to oxidative stress [GO:0006979]; response to starvation [GO:0042594]; signal transduction in response to DNA damage [GO:0042770]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase binding [GO:0031625]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0000045; GO:0000077; GO:0000086; GO:0000781; GO:0001934; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0006302; GO:0006355; GO:0006468; GO:0006915; GO:0006974; GO:0006979; GO:0008630; GO:0010332; GO:0016301; GO:0016605; GO:0018105; GO:0019901; GO:0030163; GO:0030330; GO:0031573; GO:0031625; GO:0033554; GO:0042176; GO:0042594; GO:0042770; GO:0042771; GO:0042802; GO:0042803; GO:0044773; GO:0045893; GO:0046777; GO:0050821; GO:0070534; GO:0071480; GO:0090307; GO:0106310; GO:2000002; GO:2000210; GO:2000785; GO:2000786
GN001613	GN001613.1	Q92890	56.9	51	268	307	1.22e-09	61.2	UFD1_HUMAN	Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1)	Homo sapiens (Human)	cellular response to misfolded protein [GO:0071218]; ERAD pathway [GO:0036503]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; rescue of stalled cytosolic ribosome [GO:0072344]; retrograde protein transport, ER to cytosol [GO:0030970]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]; skeletal system development [GO:0001501]; ubiquitin-dependent protein catabolic process [GO:0006511]	cysteine-type deubiquitinase activity [GO:0004843]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; polyubiquitin modification-dependent protein binding [GO:0031593]	ATPase complex [GO:1904949]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RQC complex [GO:1990112]; UFD1-NPL4 complex [GO:0036501]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	GO:0001501; GO:0004843; GO:0005634; GO:0005654; GO:0005829; GO:0006511; GO:0030970; GO:0031593; GO:0032480; GO:0034098; GO:0036435; GO:0036501; GO:0036503; GO:0039536; GO:0043161; GO:0071218; GO:0072344; GO:1904949; GO:1990112; GO:1990116
GN001617	GN001617.1	Q9I7F7	54.3	70	104	1337	3.97e-18	81.3	ACKL_DROME	Activated Cdc42 kinase-like (EC 2.7.10.2) (Tyrosine-protein kinase PR2)	Drosophila melanogaster (Fruit fly)	dorsal closure, amnioserosa morphology change [GO:0046664]; head involution [GO:0008258]; myosin filament assembly [GO:0031034]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]	plasma membrane [GO:0005886]	GO:0004713; GO:0004715; GO:0005524; GO:0005886; GO:0006468; GO:0008258; GO:0031034; GO:0046664
GN001625	GN001625.1	P31228	43.6	328	339	341	4.91e-90	276	OXDD_BOVIN	D-aspartate oxidase (DASOX) (DASPO) (DDO) (EC 1.4.3.1)	Bos taurus (Bovine)	aspartate metabolic process [GO:0006531]; D-amino acid catabolic process [GO:0019478]; nervous system process [GO:0050877]	D-aspartate oxidase activity [GO:0008445]; D-glutamate oxidase activity [GO:0047821]; FAD binding [GO:0071949]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]	GO:0005782; GO:0005829; GO:0006531; GO:0008445; GO:0019478; GO:0047821; GO:0050877; GO:0071949
GN001630	GN001630.1	Q20929	26.6	350	352	510	8.01e-22	99.8	DMSR1_CAEEL	G protein-coupled receptor dmsr-1 (Dromyosuppressin receptor related 1)	Caenorhabditis elegans	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of cellular response to heat [GO:1900034]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008188; GO:0008528; GO:0032809; GO:0045187; GO:1900034
GN001640	GN001640.1	Q3TTL0	47.1	138	232	348	6.54e-36	132	CC038_MOUSE	Uncharacterized protein C3orf38 homolog	Mus musculus (Mouse)	positive regulation of apoptotic process [GO:0043065]		nucleus [GO:0005634]	GO:0005634; GO:0043065
GN001641	GN001641.1	Q9V477	40.8	201	591	1346	1.66e-34	143	TOLL8_DROME	Toll-like receptor Tollo (Toll-like receptor 8)	Drosophila melanogaster (Fruit fly)	axis elongation [GO:0003401]; convergent extension [GO:0060026]; peripheral nervous system neuron development [GO:0048935]; regulation of glycoprotein biosynthetic process [GO:0010559]; signal transduction [GO:0007165]	receptor ligand activity [GO:0048018]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0003401; GO:0005886; GO:0007165; GO:0010559; GO:0016324; GO:0048018; GO:0048935; GO:0060026
GN001645	GN001645.1	Q8WNU8	38.7	644	651	637	4.45e-127	392	NEK11_MACFA	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	intracellular signal transduction [GO:0035556]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0004674; GO:0005524; GO:0005634; GO:0005730; GO:0006468; GO:0031573; GO:0035556; GO:0106310
GN001646	GN001646.1	Q8CHJ1	40.7	396	395	435	1.36e-100	308	PIGU_RAT	GPI-anchor transamidase component PIGU (Cell division cycle protein 91-like 1) (Protein CDC91-like 1) (GPI transamidase component PIG-U) (Liver regeneration-related protein LRRGT00059) (Phosphatidylinositol glycan anchor biosynthesis class U protein)	Rattus norvegicus (Rat)	attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; GPI anchored protein biosynthesis [GO:0180046]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	GPI anchor binding [GO:0034235]	endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; plasma membrane [GO:0005886]	GO:0005789; GO:0005886; GO:0006506; GO:0016255; GO:0034235; GO:0042765; GO:0046425; GO:0180046
GN001647	GN001647.1	Q7ZX96	53.9	575	586	820	4.32e-212	614	NUP93_XENLA	Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (An4a) (Nucleoporin Nup93)	Xenopus laevis (African clawed frog)	nuclear pore complex assembly [GO:0051292]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein import into nucleus [GO:0006606]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]	GO:0005643; GO:0005829; GO:0006606; GO:0016973; GO:0017056; GO:0031965; GO:0034399; GO:0051292
GN001648	GN001648.1	Q6NX12	56.4	236	236	820	2.38e-76	249	NUP93_XENTR	Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	nuclear pore complex assembly [GO:0051292]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein import into nucleus [GO:0006606]	structural constituent of nuclear pore [GO:0017056]	nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]	GO:0005643; GO:0006606; GO:0016973; GO:0017056; GO:0031965; GO:0034399; GO:0051292
GN001649	GN001649.1	Q6UB98	45.8	227	1026	2062	8.35e-49	193	ANR12_HUMAN	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein)	Homo sapiens (Human)			nucleoplasm [GO:0005654]	GO:0005654
GN001653	GN001653.1	O73718	66.3	315	627	414	7.29e-128	385	TBX3_CHICK	T-box transcription factor TBX3 (T-box protein 3)	Gallus gallus (Chicken)	anterior/posterior axis specification, embryo [GO:0008595]; cell fate specification [GO:0001708]; cellular senescence [GO:0090398]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; female genitalia development [GO:0030540]; follicle-stimulating hormone secretion [GO:0046884]; luteinizing hormone secretion [GO:0032275]; male genitalia development [GO:0030539]; mesoderm morphogenesis [GO:0048332]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myoblast differentiation [GO:0045662]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001501; GO:0001708; GO:0005634; GO:0006357; GO:0008595; GO:0030539; GO:0030540; GO:0032275; GO:0035115; GO:0042733; GO:0043066; GO:0043565; GO:0045662; GO:0045787; GO:0045892; GO:0045893; GO:0046884; GO:0048332; GO:0090398
GN001654	GN001654.1	O73718	63.2	315	640	414	4.32e-124	376	TBX3_CHICK	T-box transcription factor TBX3 (T-box protein 3)	Gallus gallus (Chicken)	anterior/posterior axis specification, embryo [GO:0008595]; cell fate specification [GO:0001708]; cellular senescence [GO:0090398]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; female genitalia development [GO:0030540]; follicle-stimulating hormone secretion [GO:0046884]; luteinizing hormone secretion [GO:0032275]; male genitalia development [GO:0030539]; mesoderm morphogenesis [GO:0048332]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myoblast differentiation [GO:0045662]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001501; GO:0001708; GO:0005634; GO:0006357; GO:0008595; GO:0030539; GO:0030540; GO:0032275; GO:0035115; GO:0042733; GO:0043066; GO:0043565; GO:0045662; GO:0045787; GO:0045892; GO:0045893; GO:0046884; GO:0048332; GO:0090398
GN001655	GN001655.1	Q9H6U6	45.5	888	869	928	2.51e-234	686	BCAS3_HUMAN	BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1)	Homo sapiens (Human)	autophagy [GO:0006914]; cell-cell signaling [GO:0007267]; cellular response to estrogen stimulus [GO:0071391]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin cytoskeleton organization [GO:0032956]; response to estrogen [GO:0043627]	acetyltransferase activator activity [GO:0010698]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; histone acetyltransferase binding [GO:0035035]; histone binding [GO:0042393]; nuclear receptor binding [GO:0016922]; phosphatidylinositol binding [GO:0035091]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; euchromatin [GO:0000791]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; phagophore assembly site [GO:0000407]	GO:0000407; GO:0000791; GO:0003682; GO:0005634; GO:0005737; GO:0005881; GO:0006914; GO:0007267; GO:0010595; GO:0010698; GO:0016922; GO:0031252; GO:0032956; GO:0035035; GO:0035091; GO:0042393; GO:0043085; GO:0043627; GO:0045111; GO:0045944; GO:0048487; GO:0071391
GN001659	GN001659.1	P22071	36.0	178	178	373	2.47e-21	92.4	3BHS1_RAT	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1)	Rattus norvegicus (Rat)	adrenal gland development [GO:0030325]; androgen biosynthetic process [GO:0006702]; C21-steroid hormone biosynthetic process [GO:0006700]; C21-steroid hormone metabolic process [GO:0008207]; cellular response to antibiotic [GO:0071236]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to insulin stimulus [GO:0032869]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to mercury ion [GO:0071288]; cellular response to methylmercury [GO:0071406]; cellular response to transforming growth factor beta stimulus [GO:0071560]; female gonad development [GO:0008585]; glucocorticoid biosynthetic process [GO:0006704]; granulocyte differentiation [GO:0030851]; hippocampus development [GO:0021766]; Leydig cell differentiation [GO:0033327]; male gonad development [GO:0008584]; maternal process involved in female pregnancy [GO:0060135]; phosphatidylcholine metabolic process [GO:0046470]; progesterone biosynthetic process [GO:0006701]; response to activity [GO:0014823]; response to alkaloid [GO:0043279]; response to arsenic-containing substance [GO:0046685]; response to cadmium ion [GO:0046686]; response to calcium ion [GO:0051592]; response to corticosterone [GO:0051412]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]; response to fungicide [GO:0060992]; response to herbicide [GO:0009635]; response to L-ascorbic acid [GO:0033591]; response to lead ion [GO:0010288]; response to metal ion [GO:0010038]; response to nutrient levels [GO:0031667]; response to vitamin E [GO:0033197]; response to xenobiotic stimulus [GO:0009410]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]	3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854]; 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity [GO:0000253]; 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity [GO:0047024]; NAD binding [GO:0051287]; steroid binding [GO:0005496]; steroid Delta-isomerase activity [GO:0004769]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]	GO:0000253; GO:0003854; GO:0004769; GO:0005496; GO:0005737; GO:0005743; GO:0005758; GO:0005783; GO:0005789; GO:0006694; GO:0006700; GO:0006701; GO:0006702; GO:0006704; GO:0008202; GO:0008207; GO:0008584; GO:0008585; GO:0009410; GO:0009635; GO:0010038; GO:0010288; GO:0014823; GO:0021766; GO:0030061; GO:0030325; GO:0030851; GO:0031667; GO:0032355; GO:0032869; GO:0033197; GO:0033327; GO:0033591; GO:0043279; GO:0044344; GO:0045471; GO:0046470; GO:0046685; GO:0046686; GO:0047024; GO:0051287; GO:0051412; GO:0051592; GO:0060135; GO:0060992; GO:0070301; GO:0070542; GO:0071236; GO:0071288; GO:0071320; GO:0071333; GO:0071371; GO:0071372; GO:0071373; GO:0071406; GO:0071549; GO:0071560
GN001660	GN001660.1	P26439	34.1	179	188	372	8.27e-20	88.6	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) (3-beta-HSD adrenal and gonadal type) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)]	Homo sapiens (Human)	androgen biosynthetic process [GO:0006702]; C21-steroid hormone metabolic process [GO:0008207]; steroid biosynthetic process [GO:0006694]	3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854]; steroid Delta-isomerase activity [GO:0004769]	ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; intercellular bridge [GO:0045171]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; smooth endoplasmic reticulum membrane [GO:0030868]	GO:0003854; GO:0004769; GO:0005737; GO:0005743; GO:0005758; GO:0005783; GO:0005789; GO:0006694; GO:0006702; GO:0008207; GO:0016020; GO:0030868; GO:0031966; GO:0035869; GO:0045171
GN001662	GN001662.1	P22770	29.9	164	238	502	7.54e-17	82.4	ACHA7_CHICK	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005737; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030424; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043204; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN001666	GN001666.1	Q9Z2A7	62.9	62	95	498	1.88e-18	81.6	DGAT1_MOUSE	Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase)	Mus musculus (Mouse)	diacylglycerol metabolic process [GO:0046339]; fatty acid homeostasis [GO:0055089]; glycerolipid metabolic process [GO:0046486]; insulin secretion [GO:0030073]; lipid storage [GO:0019915]; lipid transport [GO:0006869]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; monoacylglycerol biosynthetic process [GO:0006640]; poly-hydroxybutyrate biosynthetic process [GO:0042619]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of eating behavior [GO:1903998]; regulation of intestinal lipid absorption [GO:1904729]; regulation of vitamin A metabolic process [GO:1901738]; retinoid metabolic process [GO:0001523]; triglyceride biosynthetic process [GO:0019432]; very-low-density lipoprotein particle assembly [GO:0034379]	2-acylglycerol O-acyltransferase activity [GO:0003846]; acyltransferase activity [GO:0016746]; diacylglycerol binding [GO:0019992]; diacylglycerol O-acyltransferase activity [GO:0004144]; fatty acid binding [GO:0005504]; identical protein binding [GO:0042802]; long-chain-alcohol O-fatty-acyltransferase activity [GO:0047196]; retinol O-fatty-acyltransferase activity [GO:0050252]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0001523; GO:0003846; GO:0004144; GO:0005504; GO:0005789; GO:0006640; GO:0006869; GO:0010867; GO:0016020; GO:0016746; GO:0019432; GO:0019915; GO:0019992; GO:0030073; GO:0034379; GO:0035336; GO:0042619; GO:0042802; GO:0046321; GO:0046339; GO:0046486; GO:0047196; GO:0050252; GO:0055089; GO:1901738; GO:1903998; GO:1904729; GO:2000491
GN001667	GN001667.1	Q2T9Q1	51.1	276	272	403	3.22e-84	260	TBC20_BOVIN	TBC1 domain family member 20	Bos taurus (Bovine)	COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; host-mediated activation of viral genome replication [GO:0044829]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; virion assembly [GO:0019068]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]	GO:0000139; GO:0005096; GO:0005789; GO:0006888; GO:0007030; GO:0019068; GO:0031267; GO:0031965; GO:0044829; GO:0046726; GO:0090110; GO:1902953
GN001668	GN001668.1	Q9UBD0	38.5	122	168	423	8.65e-14	71.2	HSFX1_HUMAN	Heat shock transcription factor, X-linked	Homo sapiens (Human)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0005634; GO:0005829; GO:0006357
GN001669	GN001669.1	Q9H6D7	32.1	336	369	363	1.83e-42	154	HAUS4_HUMAN	HAUS augmin-like complex subunit 4	Homo sapiens (Human)	centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]		centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]	GO:0005813; GO:0005829; GO:0007098; GO:0010968; GO:0051225; GO:0070652; GO:1990498
GN001670	GN001670.1	P83436	40.3	685	722	770	4.80e-162	489	COG7_HUMAN	Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7)	Homo sapiens (Human)	glycoprotein biosynthetic process [GO:0009101]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein localization to Golgi apparatus [GO:0034067]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]		COG complex [GO:0017119]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network membrane [GO:0032588]	GO:0000139; GO:0000301; GO:0005794; GO:0006886; GO:0006890; GO:0007030; GO:0009101; GO:0017119; GO:0032588; GO:0033365; GO:0034067; GO:0050821
GN001673	GN001673.1	Q8C206	29.5	329	345	330	2.58e-33	129	GP157_MOUSE	G protein-coupled receptor 157	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; radial glial cell differentiation [GO:0060019]	G protein-coupled receptor activity [GO:0004930]	ciliary membrane [GO:0060170]	GO:0004930; GO:0007166; GO:0007189; GO:0007200; GO:0048512; GO:0060019; GO:0060170
GN001678	GN001678.1	Q6AZB8	29.9	184	190	349	9.44e-19	85.5	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN001689	GN001689.1	Q9CUX1	27.7	202	213	758	4.20e-18	85.5	P52K_MOUSE	52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (THAP domain-containing protein 0) (THAP domain-containing protein 12)	Mus musculus (Mouse)		protein dimerization activity [GO:0046983]	nucleus [GO:0005634]	GO:0005634; GO:0046983
GN001692	GN001692.1	Q0WVW7	64.6	65	80	911	9.70e-23	93.2	RQL5_ARATH	ATP-dependent DNA helicase Q-like 5 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ5) (RecQ-like protein 5) (AtRecQ5) (AtRecQl5)	Arabidopsis thaliana (Mouse-ear cress)	cellular response to water deprivation [GO:0042631]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003676; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006310; GO:0016887; GO:0042631; GO:0043138
GN001694	GN001694.1	P14003	50.8	61	318	337	6.84e-11	65.9	HAIR_DROME	Protein hairy	Drosophila melanogaster (Fruit fly)	anterior/posterior pattern specification [GO:0009952]; cell morphogenesis [GO:0000902]; membrane organization [GO:0061024]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; open tracheal system development [GO:0007424]; periodic partitioning by pair rule gene [GO:0007366]; posterior head segmentation [GO:0035289]; regulation of neurogenesis [GO:0050767]; response to hypoxia [GO:0001666]; salivary gland morphogenesis [GO:0007435]; trunk segmentation [GO:0035290]; tube morphogenesis [GO:0035239]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]	nucleus [GO:0005634]	GO:0000122; GO:0000902; GO:0000978; GO:0000981; GO:0001222; GO:0001227; GO:0001666; GO:0003677; GO:0005634; GO:0007366; GO:0007399; GO:0007424; GO:0007435; GO:0009952; GO:0035239; GO:0035289; GO:0035290; GO:0045892; GO:0046983; GO:0050767; GO:0061024; GO:0070888
GN001695	GN001695.1	Q8WY54	43.7	403	840	755	9.45e-101	332	PPM1E_HUMAN	Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA)	Homo sapiens (Human)	cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of protein kinase activity [GO:0006469]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of stress fiber assembly [GO:0051496]	cation binding [GO:0043169]; protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0004722; GO:0005634; GO:0005737; GO:0006469; GO:0032991; GO:0035970; GO:0043169; GO:0051496; GO:0071222; GO:0071466
GN001698	GN001698.1	P46088	39.2	204	255	203	8.93e-36	129	GST_NOTSL	Glutathione S-transferase (EC 2.5.1.18) (GST class-sigma)	Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei)	glutathione metabolic process [GO:0006749]	glutathione transferase activity [GO:0004364]	cytoplasm [GO:0005737]	GO:0004364; GO:0005737; GO:0006749
GN001699	GN001699.1	P91253	38.6	210	194	206	1.17e-32	119	GST7_CAEEL	Probable glutathione S-transferase 7 (EC 2.5.1.18) (GST class-sigma)	Caenorhabditis elegans	glutathione metabolic process [GO:0006749]; innate immune response [GO:0045087]	glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]	cytoplasm [GO:0005737]	GO:0004364; GO:0004602; GO:0005737; GO:0006749; GO:0045087
GN001700	GN001700.1	P46088	40.2	209	205	203	7.65e-42	143	GST_NOTSL	Glutathione S-transferase (EC 2.5.1.18) (GST class-sigma)	Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei)	glutathione metabolic process [GO:0006749]	glutathione transferase activity [GO:0004364]	cytoplasm [GO:0005737]	GO:0004364; GO:0005737; GO:0006749
GN001706	GN001706.1	Q09225	25.4	645	882	822	2.36e-50	194	NRF6_CAEEL	Nose resistant to fluoxetine protein 6 (Protein nrf-6)	Caenorhabditis elegans		acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]	membrane [GO:0016020]	GO:0016020; GO:0016747
GN001707	GN001707.1	Q09225	25.6	726	868	822	4.67e-63	231	NRF6_CAEEL	Nose resistant to fluoxetine protein 6 (Protein nrf-6)	Caenorhabditis elegans		acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]	membrane [GO:0016020]	GO:0016020; GO:0016747
GN001709	GN001709.1	Q86YT5	43.2	597	637	568	3.51e-144	433	S13A5_HUMAN	Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5)	Homo sapiens (Human)	alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; citrate transport [GO:0015746]; fumarate transport [GO:0015741]; oxaloacetate transport [GO:0015729]; succinate transport [GO:0015744]; transmembrane transport [GO:0055085]	citrate transmembrane transporter activity [GO:0015137]; identical protein binding [GO:0042802]; organic acid:sodium symporter activity [GO:0005343]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]	plasma membrane [GO:0005886]	GO:0005343; GO:0005886; GO:0015137; GO:0015141; GO:0015729; GO:0015741; GO:0015742; GO:0015744; GO:0015746; GO:0017153; GO:0042802; GO:0055085; GO:0071285
GN001710	GN001710.1	Q2PGG3	45.5	264	277	331	3.72e-70	222	SRR_ARATH	Serine racemase (AtSR) (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17)	Arabidopsis thaliana (Mouse-ear cress)	D-serine biosynthetic process [GO:0070179]; L-serine metabolic process [GO:0006563]	ATP binding [GO:0005524]; D-serine ammonia-lyase activity [GO:0008721]; L-serine ammonia-lyase activity [GO:0003941]; magnesium ion binding [GO:0000287]; pyridoxal phosphate binding [GO:0030170]; serine racemase activity [GO:0030378]	chloroplast [GO:0009507]	GO:0000287; GO:0003941; GO:0005524; GO:0006563; GO:0008721; GO:0009507; GO:0030170; GO:0030378; GO:0070179
GN001717	GN001717.1	Q9UPW0	34.4	520	422	622	5.50e-73	243	FOXJ3_HUMAN	Forkhead box protein J3	Homo sapiens (Human)	male meiosis I [GO:0007141]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0006357; GO:0007141; GO:0007283; GO:0043565; GO:0045944; GO:1990837
GN001718	GN001718.1	Q0V9R3	51.2	823	1168	834	1.40e-279	809	DI3L2_XENTR	DIS3-like exonuclease 2 (EC 3.1.13.-)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	miRNA catabolic process [GO:0010587]; mRNA catabolic process [GO:0006402]; nuclear-transcribed mRNA catabolic process [GO:0000956]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; stem cell population maintenance [GO:0019827]	3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; poly(U) RNA binding [GO:0008266]	cytoplasm [GO:0005737]; P-body [GO:0000932]	GO:0000175; GO:0000287; GO:0000932; GO:0000956; GO:0005737; GO:0006402; GO:0008266; GO:0010587; GO:0019827; GO:1990074
GN001719	GN001719.1	P55937	32.3	130	1606	1487	1.75e-10	70.1	GOGA3_MOUSE	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2)	Mus musculus (Mouse)			cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0000139; GO:0005654; GO:0005730; GO:0005793; GO:0005794; GO:0005829; GO:0032580
GN001721	GN001721.1	Q505F5	43.6	346	531	581	4.32e-65	224	LRC47_MOUSE	Leucine-rich repeat-containing protein 47	Mus musculus (Mouse)	phenylalanyl-tRNA aminoacylation [GO:0006432]	phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723]		GO:0003723; GO:0004826; GO:0006432
GN001722	GN001722.1	P34410	26.5	351	468	557	1.90e-32	133	TWK7_CAEEL	TWiK family of potassium channels protein 7	Caenorhabditis elegans		potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]	GO:0005886; GO:0022841
GN001724	GN001724.1	P98187	41.7	470	641	520	1.92e-115	358	CP4F8_HUMAN	Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8)	Homo sapiens (Human)	arachidonate metabolic process [GO:0019369]; icosanoid metabolic process [GO:0006690]; menaquinone catabolic process [GO:0042361]; phylloquinone catabolic process [GO:0042376]; prostaglandin metabolic process [GO:0006693]	alkane 1-monooxygenase activity [GO:0018685]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	endoplasmic reticulum membrane [GO:0005789]	GO:0004497; GO:0005506; GO:0005789; GO:0006690; GO:0006693; GO:0016712; GO:0018685; GO:0019369; GO:0020037; GO:0042361; GO:0042376
GN001725	GN001725.1	P26221	51.6	442	572	880	3.30e-137	423	GUN4_THEFU	Endoglucanase E-4 (EC 3.2.1.4) (Cellulase E-4) (Cellulase E4) (Endo-1,4-beta-glucanase E-4)	Thermobifida fusca (Thermomonospora fusca)	cellulose catabolic process [GO:0030245]	cellulase activity [GO:0008810]; cellulose binding [GO:0030248]		GO:0008810; GO:0030245; GO:0030248
GN001728	GN001728.1	P26221	51.6	444	772	880	5.67e-135	424	GUN4_THEFU	Endoglucanase E-4 (EC 3.2.1.4) (Cellulase E-4) (Cellulase E4) (Endo-1,4-beta-glucanase E-4)	Thermobifida fusca (Thermomonospora fusca)	cellulose catabolic process [GO:0030245]	cellulase activity [GO:0008810]; cellulose binding [GO:0030248]		GO:0008810; GO:0030245; GO:0030248
GN001731	GN001731.1	O88833	36.6	142	196	509	3.11e-23	99.4	CP4AA_MOUSE	Cytochrome P450 4A10 (CYPIVA10) (Cytochrome P450-LA-omega 1) (Cytochrome P452) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)	Mus musculus (Mouse)	arachidonate metabolic process [GO:0019369]; fatty acid metabolic process [GO:0006631]; icosanoid biosynthetic process [GO:0046456]; kidney development [GO:0001822]; lauric acid metabolic process [GO:0048252]; linoleic acid metabolic process [GO:0043651]	16-hydroxypalmitate dehydrogenase activity [GO:0103002]; alkane 1-monooxygenase activity [GO:0018685]; arachidonate epoxygenase activity [GO:0008392]; arachidonate monooxygenase activity [GO:0008391]; arachidonate omega-hydroxylase activity [GO:0052869]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; long-chain fatty acid omega-1 hydroxylase activity [GO:0120319]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; medium-chain fatty acid omega-hydroxylase activity [GO:0140981]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]	GO:0001822; GO:0004497; GO:0005506; GO:0005576; GO:0005737; GO:0005789; GO:0006631; GO:0008391; GO:0008392; GO:0016324; GO:0016712; GO:0018685; GO:0019369; GO:0020037; GO:0043231; GO:0043651; GO:0046456; GO:0048252; GO:0050051; GO:0052869; GO:0102033; GO:0103002; GO:0120319; GO:0140981
GN001737	GN001737.1	P34457	37.8	127	240	286	1.15e-18	85.9	YMD3_CAEEL	Putative uncharacterized transposon-derived protein F54H12.3	Caenorhabditis elegans	DNA integration [GO:0015074]	nucleic acid binding [GO:0003676]		GO:0003676; GO:0015074
GN001742	GN001742.1	Q86YJ7	53.1	597	570	626	7.03e-193	557	AN13B_HUMAN	Ankyrin repeat domain-containing protein 13B	Homo sapiens (Human)	negative regulation of receptor internalization [GO:0002091]; regulation of receptor-mediated endocytosis [GO:0048259]	ubiquitin-modified protein reader activity [GO:0140036]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0002091; GO:0005737; GO:0005769; GO:0005770; GO:0005886; GO:0048259; GO:0048471; GO:0140036
GN001743	GN001743.1	O88630	62.1	145	139	250	1.48e-52	169	GOSR1_MOUSE	Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28)	Mus musculus (Mouse)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; inter-Golgi cisterna vesicle-mediated transport [GO:0048219]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion [GO:0006906]	SNAP receptor activity [GO:0005484]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; SNARE complex [GO:0031201]	GO:0000139; GO:0005484; GO:0005794; GO:0005797; GO:0005801; GO:0005829; GO:0006888; GO:0006906; GO:0031201; GO:0042147; GO:0048219
GN001744	GN001744.1	A1K5T6	42.2	512	572	519	5.44e-127	385	SELO_AZOSB	Protein nucleotidyltransferase YdiU (EC 2.7.7.-) (Protein adenylyltransferase YdiU) (EC 2.7.7.108) (Protein uridylyltransferase YdiU) (EC 2.7.7.-)	Azoarcus sp. (strain BH72)		AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]		GO:0000287; GO:0005524; GO:0030145; GO:0070733
GN001745	GN001745.1	F1RKB1	35.2	457	495	467	3.64e-66	223	DRC10_PIG	Dynein regulatory complex subunit 10 (IQ domain-containing protein D)	Sus scrofa (Pig)			ciliary basal body [GO:0036064]	GO:0036064
GN001746	GN001746.1	Q9H773	54.2	48	73	170	2.18e-10	56.2	DCTP1_HUMAN	dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein)	Homo sapiens (Human)	dCTP catabolic process [GO:0006253]; DNA protection [GO:0042262]; nucleoside triphosphate catabolic process [GO:0009143]	dCTP diphosphatase activity [GO:0047840]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleoside triphosphate diphosphatase activity [GO:0047429]; pyrimidine deoxyribonucleotide binding [GO:0032556]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0005634; GO:0005654; GO:0005739; GO:0005829; GO:0006253; GO:0009143; GO:0032556; GO:0042262; GO:0042802; GO:0047429; GO:0047840
GN001747	GN001747.1	Q32KY6	54.2	48	73	169	8.83e-09	52.0	DCTP1_BOVIN	dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1)	Bos taurus (Bovine)	dCTP catabolic process [GO:0006253]; DNA protection [GO:0042262]; nucleoside triphosphate catabolic process [GO:0009143]	dCTP diphosphatase activity [GO:0047840]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleoside triphosphate diphosphatase activity [GO:0047429]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0000287; GO:0005634; GO:0005739; GO:0005829; GO:0006253; GO:0009143; GO:0042262; GO:0042802; GO:0047429; GO:0047840
GN001748	GN001748.1	Q6DDL7	41.2	131	190	460	2.07e-30	118	UN93A_XENLA	N-acetylglucosamine transporter UNC93A (Protein unc-93 homolog A) (Unc-93A)	Xenopus laevis (African clawed frog)		N-acetylglucosamine transmembrane transporter activity [GO:0015572]	plasma membrane [GO:0005886]	GO:0005886; GO:0015572
GN001749	GN001749.1	A2VE54	36.4	434	458	457	2.26e-78	254	UN93A_BOVIN	N-acetylglucosamine transporter UNC93A (Protein unc-93 homolog A) (Unc-93A)	Bos taurus (Bovine)		N-acetylglucosamine transmembrane transporter activity [GO:0015572]	plasma membrane [GO:0005886]	GO:0005886; GO:0015572
GN001750	GN001750.1	Q91W98	39.2	572	629	574	1.61e-119	370	S15A4_MOUSE	Solute carrier family 15 member 4 (Peptide/histidine transporter 1)	Mus musculus (Mouse)	dipeptide import across plasma membrane [GO:0140206]; histidine transport [GO:0015817]; L-histidine transmembrane export from vacuole [GO:0089708]; mast cell homeostasis [GO:0033023]; peptidoglycan transport [GO:0015835]; positive regulation of innate immune response [GO:0045089]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 8 signaling pathway [GO:0034161]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]	dipeptide transmembrane transporter activity [GO:0071916]; L-histidine transmembrane transporter activity [GO:0005290]; peptide:proton symporter activity [GO:0015333]; peptidoglycan transmembrane transporter activity [GO:0015647]	early endosome membrane [GO:0031901]; endolysosome membrane [GO:0036020]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]	GO:0005290; GO:0005765; GO:0010008; GO:0015333; GO:0015647; GO:0015817; GO:0015835; GO:0031901; GO:0033023; GO:0034157; GO:0034161; GO:0034165; GO:0036020; GO:0045089; GO:0048302; GO:0070424; GO:0070430; GO:0070434; GO:0071916; GO:0089708; GO:0140206
GN001752	GN001752.1	Q96TW9	21.8	449	460	489	5.85e-16	83.6	MCH1_WICAO	Probable transporter MCH1	Wickerhamomyces anomalus (Yeast) (Hansenula anomala)		transmembrane transporter activity [GO:0022857]	fungal-type vacuole membrane [GO:0000329]	GO:0000329; GO:0022857
GN001759	GN001759.1	Q5ZI27	31.1	135	243	330	3.90e-10	62.4	NAIF1_CHICK	Nuclear apoptosis-inducing factor 1	Gallus gallus (Chicken)	homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705]; oogenesis [GO:0048477]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]; spermatogenesis [GO:0007283]		central element [GO:0000801]; nucleus [GO:0005634]	GO:0000801; GO:0005634; GO:0007129; GO:0007283; GO:0010705; GO:0048477; GO:1902108
GN001760	GN001760.1	Q17QR8	37.3	316	352	349	2.03e-58	195	HARB1_BOVIN	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Bos taurus (Bovine)			cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005829; GO:0005886
GN001772	GN001772.1	Q922K7	74.3	144	145	793	5.96e-70	227	NOP2_MOUSE	28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120)	Mus musculus (Mouse)	blastocyst formation [GO:0001825]; maturation of LSU-rRNA [GO:0000470]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA base methylation [GO:0070475]; rRNA processing [GO:0006364]	RNA binding [GO:0003723]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383]	nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0000027; GO:0000470; GO:0001825; GO:0003723; GO:0005634; GO:0005730; GO:0006364; GO:0009383; GO:0042273; GO:0070475; GO:1901796
GN001774	GN001774.1	P19623	70.4	287	299	302	3.55e-156	441	SPEE_HUMAN	Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)	Homo sapiens (Human)	polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; spermidine synthase activity [GO:0004766]	cytosol [GO:0005829]	GO:0004766; GO:0005829; GO:0006595; GO:0006597; GO:0008295; GO:0042802; GO:0042803
GN001776	GN001776.1	Q4KKZ1	44.6	92	152	196	8.60e-20	84.3	CF107_MOUSE	Cilia- and flagella-associated protein 107	Mus musculus (Mouse)	flagellated sperm motility [GO:0030317]		axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; sperm flagellum [GO:0036126]	GO:0005879; GO:0030317; GO:0036126; GO:0160111
GN001777	GN001777.1	Q9Y2G8	29.9	790	775	782	2.60e-88	298	DJC16_HUMAN	DnaJ homolog subfamily C member 16 (Endoplasmic reticulum DNA J domain-containing protein 8) (ER-resident protein ERdj8) (ERdj8)	Homo sapiens (Human)	regulation of autophagosome size [GO:0016243]		endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0016243
GN001779	GN001779.1	Q3ZBV2	65.8	421	496	478	8.29e-201	569	DD19A_BOVIN	ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DEAD box protein 19A)	Bos taurus (Bovine)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleoplasm [GO:0005654]	GO:0003676; GO:0003724; GO:0005524; GO:0005654; GO:0005737; GO:0010494; GO:0016887
GN001780	GN001780.1	Q08AW4	44.4	239	1002	748	6.40e-65	237	PKHM3_XENLA	Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3)	Xenopus laevis (African clawed frog)	myoblast differentiation [GO:0045445]		cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	GO:0005737; GO:0005794; GO:0005886; GO:0045445
GN001782	GN001782.1	Q9BG96	28.5	221	458	470	1.25e-17	88.6	NR0B1_PONPY	Nuclear receptor subfamily 0 group B member 1 (Nuclear receptor DAX-1)	Pongo pygmaeus (Bornean orangutan)	adrenal gland development [GO:0030325]; gonad development [GO:0008406]; intracellular protein localization [GO:0008104]; male gonad development [GO:0008584]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; spermatogenesis [GO:0007283]	DNA hairpin binding [GO:0032448]; nuclear receptor binding [GO:0016922]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]	GO:0000122; GO:0003714; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005840; GO:0007283; GO:0008104; GO:0008406; GO:0008584; GO:0010894; GO:0016020; GO:0016922; GO:0019904; GO:0030325; GO:0032448; GO:0033144; GO:0042803; GO:0045892
GN001784	GN001784.1	A8Y1P7	44.7	235	337	384	3.00e-66	216	BRE4_CAEBR	Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.244) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)	Caenorhabditis briggsae	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; positive regulation of Notch signaling pathway [GO:0045747]; response to toxic substance [GO:0009636]	N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0005794; GO:0005975; GO:0006688; GO:0009101; GO:0009636; GO:0016020; GO:0033842; GO:0045747
GN001786	GN001786.1	Q8C1B2	31.4	440	949	657	8.65e-46	179	PARPT_MOUSE	Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (TCDD-inducible poly [ADP-ribose] polymerase)	Mus musculus (Mouse)	androgen metabolic process [GO:0008209]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; female gonad development [GO:0008585]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; negative regulation of gene expression [GO:0010629]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of protein catabolic process [GO:0045732]; post-embryonic development [GO:0009791]; protein auto-ADP-ribosylation [GO:0070213]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745]; vasculogenesis [GO:0001570]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; metal ion binding [GO:0046872]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]	nucleus [GO:0005634]	GO:0000987; GO:0001570; GO:0001822; GO:0003950; GO:0005634; GO:0008209; GO:0008210; GO:0008585; GO:0009791; GO:0010629; GO:0030097; GO:0045732; GO:0046872; GO:0048008; GO:0048705; GO:0048745; GO:0060021; GO:0060325; GO:0070213; GO:0140803; GO:0140806; GO:0140807; GO:1904612; GO:1990404
GN001791	GN001791.1	Q7Z3E1	50.0	128	134	657	1.30e-28	112	PARPT_HUMAN	Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase)	Homo sapiens (Human)	negative regulation of gene expression [GO:0010629]; positive regulation of protein catabolic process [GO:0045732]; protein auto-ADP-ribosylation [GO:0070213]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; metal ion binding [GO:0046872]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]	nucleus [GO:0005634]	GO:0000987; GO:0003950; GO:0005634; GO:0010629; GO:0045732; GO:0046872; GO:0070213; GO:0140803; GO:0140806; GO:0140807; GO:1904612; GO:1990404
GN001792	GN001792.1	A9UL59	30.6	186	202	191	7.55e-14	70.1	LHPL7_XENTR	LHFPL tetraspan subfamily member 7 protein (Transmembrane protein 211)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			membrane [GO:0016020]	GO:0016020
GN001795	GN001795.1	Q95YD4	26.0	223	1502	867	5.78e-13	77.8	KIN32_CAEEL	Inactive tyrosine-protein kinase kin-32	Caenorhabditis elegans	signal complex assembly [GO:0007172]	ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713]	focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	GO:0004713; GO:0005524; GO:0005886; GO:0005925; GO:0007172
GN001796	GN001796.1	Q95YD4	27.2	224	372	867	7.35e-16	82.8	KIN32_CAEEL	Inactive tyrosine-protein kinase kin-32	Caenorhabditis elegans	signal complex assembly [GO:0007172]	ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713]	focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	GO:0004713; GO:0005524; GO:0005886; GO:0005925; GO:0007172
GN001797	GN001797.1	A0A345BJN8	32.0	203	590	919	4.84e-24	110	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN001800	GN001800.1	Q6NRC9	40.6	471	646	1030	2.72e-26	118	LRCC1_XENLA	Leucine-rich repeat and coiled-coil domain-containing protein 1	Xenopus laevis (African clawed frog)			centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]	GO:0005737; GO:0005813; GO:0005814
GN001801	GN001801.1	P05153	67.9	433	471	622	3.67e-223	630	PCKGC_CHICK	Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) (Serine-protein kinase PCK1) (EC 2.7.11.-)	Gallus gallus (Chicken)	adult feeding behavior [GO:0008343]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to parathyroid hormone stimulus [GO:0071374]; developmental growth [GO:0048589]; digestion [GO:0007586]; egg-laying behavior [GO:0018991]; eggshell formation [GO:0030703]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic organ morphogenesis [GO:0048562]; gluconeogenesis [GO:0006094]; glycerol biosynthetic process from pyruvate [GO:0046327]; hepatocyte differentiation [GO:0070365]; intestinal absorption [GO:0050892]; negative regulation of carbohydrate metabolic process [GO:0045912]; oxaloacetate metabolic process [GO:0006107]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of carbohydrate metabolic process [GO:0045913]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of memory T cell differentiation [GO:0043382]; regulation of feeding behavior [GO:0060259]; regulation of gluconeogenesis [GO:0006111]; regulation of lipid biosynthetic process [GO:0046890]; response to cAMP [GO:0051591]; response to starvation [GO:0042594]; sexual reproduction [GO:0019953]; vitellogenesis [GO:0007296]	epinephrine binding [GO:0051379]; GTP binding [GO:0005525]; manganese ion binding [GO:0030145]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613]; protein serine kinase activity (using GTP as donor) [GO:0106264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]	GO:0004613; GO:0005525; GO:0005737; GO:0005739; GO:0005783; GO:0005829; GO:0006094; GO:0006107; GO:0006111; GO:0007296; GO:0007586; GO:0008343; GO:0009792; GO:0018105; GO:0018991; GO:0019953; GO:0030145; GO:0030703; GO:0032869; GO:0042149; GO:0042594; GO:0043382; GO:0045722; GO:0045912; GO:0045913; GO:0046327; GO:0046890; GO:0048562; GO:0048589; GO:0050892; GO:0051379; GO:0051591; GO:0060259; GO:0070365; GO:0071333; GO:0071374; GO:0071549; GO:0106264
GN001802	GN001802.1	Q16822	58.7	46	49	640	8.49e-12	60.5	PCKGM_HUMAN	Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxykinase 2, mitochondrial) (mtPCK2) (Serine/threonine-protein kinase PCK2) (EC 2.7.11.-)	Homo sapiens (Human)	cellular response to dexamethasone stimulus [GO:0071549]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to tumor necrosis factor [GO:0071356]; gluconeogenesis [GO:0006094]; glycerol biosynthetic process from pyruvate [GO:0046327]; hepatocyte differentiation [GO:0070365]; oxaloacetate metabolic process [GO:0006107]; positive regulation of ferroptosis [GO:0160020]; positive regulation of insulin secretion [GO:0032024]; pyruvate biosynthetic process [GO:0042866]; response to lipopolysaccharide [GO:0032496]; response to starvation [GO:0042594]	GTP binding [GO:0005525]; manganese ion binding [GO:0030145]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613]; phosphoenolpyruvate carboxykinase activity [GO:0004611]; protein serine/threonine kinase activity [GO:0004674]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004611; GO:0004613; GO:0004674; GO:0005525; GO:0005739; GO:0005759; GO:0006094; GO:0006107; GO:0030145; GO:0032024; GO:0032496; GO:0032869; GO:0042594; GO:0042866; GO:0046327; GO:0070365; GO:0071333; GO:0071356; GO:0071549; GO:0160020
GN001805	GN001805.1	P29190	55.5	616	544	619	7.14e-254	711	PCKG_HAECO	Phosphoenolpyruvate carboxykinase [GTP] (PEPCK) (EC 4.1.1.32)	Haemonchus contortus (Barber pole worm)	cellular response to glucose stimulus [GO:0071333]; gluconeogenesis [GO:0006094]; glycerol biosynthetic process from pyruvate [GO:0046327]; oxaloacetate metabolic process [GO:0006107]; propionate catabolic process [GO:0019543]; response to lipid [GO:0033993]; response to starvation [GO:0042594]	GTP binding [GO:0005525]; manganese ion binding [GO:0030145]; phosphoenolpyruvate carboxykinase (GTP) activity [GO:0004613]	cytosol [GO:0005829]	GO:0004613; GO:0005525; GO:0005829; GO:0006094; GO:0006107; GO:0019543; GO:0030145; GO:0033993; GO:0042594; GO:0046327; GO:0071333
GN001807	GN001807.1	Q9VY77	67.0	279	754	728	9.74e-131	408	AJUBA_DROME	LIM domain-containing protein jub	Drosophila melanogaster (Fruit fly)	cytoskeleton organization [GO:0007010]; follicle cell of egg chamber development [GO:0030707]; mitotic cell cycle [GO:0000278]; negative regulation of hippo signaling [GO:0035331]; positive regulation of imaginal disc growth [GO:0045572]; protein localization to centrosome [GO:0071539]; regulation of DNA-templated transcription [GO:0006355]; response to hypoxia [GO:0001666]	protein sequestering activity [GO:0140311]; transcription corepressor activity [GO:0003714]	adherens junction [GO:0005912]; apical cortex [GO:0045179]; nucleus [GO:0005634]; P-body [GO:0000932]; transcription regulator complex [GO:0005667]	GO:0000278; GO:0000932; GO:0001666; GO:0003714; GO:0005634; GO:0005667; GO:0005912; GO:0006355; GO:0007010; GO:0030707; GO:0035331; GO:0045179; GO:0045572; GO:0071539; GO:0140311
GN001809	GN001809.1	Q0V8J4	29.6	338	516	891	5.09e-32	134	VWA7_BOVIN	von Willebrand factor A domain-containing protein 7 (Protein G7c)	Bos taurus (Bovine)			extracellular region [GO:0005576]	GO:0005576
GN001810	GN001810.1	P78412	63.5	126	422	446	2.25e-38	147	IRX6_HUMAN	Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6)	Homo sapiens (Human)	cell development [GO:0048468]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0030182; GO:0048468
GN001816	GN001816.1	Q0KHY3	26.3	830	1015	1454	4.41e-54	209	MESH_DROME	Protein mesh	Drosophila melanogaster (Fruit fly)	cell-matrix adhesion [GO:0007160]; smooth septate junction assembly [GO:0090528]		apicolateral plasma membrane [GO:0016327]; plasma membrane [GO:0005886]; smooth septate junction [GO:0005920]	GO:0005886; GO:0005920; GO:0007160; GO:0016327; GO:0090528
GN001818	GN001818.1	Q4LDE5	23.2	367	640	3571	3.43e-12	73.9	SVEP1_HUMAN	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)	Homo sapiens (Human)	epidermis development [GO:0008544]; lymph vessel morphogenesis [GO:0036303]; negative regulation of vasoconstriction [GO:0045906]; positive regulation of platelet activation [GO:0010572]	calcium ion binding [GO:0005509]; chromatin binding [GO:0003682]; integrin binding [GO:0005178]; integrin binding involved in cell-matrix adhesion [GO:0098640]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0003682; GO:0005178; GO:0005509; GO:0005576; GO:0005634; GO:0005737; GO:0008544; GO:0010572; GO:0016020; GO:0036303; GO:0045906; GO:0098640
GN001819	GN001819.1	Q0KHY3	26.8	1014	1121	1454	1.67e-72	268	MESH_DROME	Protein mesh	Drosophila melanogaster (Fruit fly)	cell-matrix adhesion [GO:0007160]; smooth septate junction assembly [GO:0090528]		apicolateral plasma membrane [GO:0016327]; plasma membrane [GO:0005886]; smooth septate junction [GO:0005920]	GO:0005886; GO:0005920; GO:0007160; GO:0016327; GO:0090528
GN001823	GN001823.1	P43114	31.1	318	381	488	1.66e-36	141	PE2R4_RAT	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Rattus norvegicus (Rat)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to glucose stimulus [GO:0071333]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nematode [GO:0009624]; response to progesterone [GO:0032570]; response to prostaglandin E [GO:0034695]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; response to xenobiotic stimulus [GO:0009410]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009410; GO:0009612; GO:0009624; GO:0010628; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032570; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060135; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0070555; GO:0071260; GO:0071333; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1902074; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1990785; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN001824	GN001824.1	Q8MJ08	37.1	205	361	492	1.86e-29	121	PE2R4_BOVIN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0007188; GO:0007189; GO:0007204; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN001825	GN001825.1	Q8MJ08	36.8	212	254	492	1.57e-32	127	PE2R4_BOVIN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0007188; GO:0007189; GO:0007204; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN001829	GN001829.1	Q8MJ08	37.1	205	361	492	1.86e-29	121	PE2R4_BOVIN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0007188; GO:0007189; GO:0007204; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN001830	GN001830.1	P43114	28.1	352	334	488	1.28e-25	110	PE2R4_RAT	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Rattus norvegicus (Rat)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to glucose stimulus [GO:0071333]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nematode [GO:0009624]; response to progesterone [GO:0032570]; response to prostaglandin E [GO:0034695]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; response to xenobiotic stimulus [GO:0009410]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009410; GO:0009612; GO:0009624; GO:0010628; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032570; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060135; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0070555; GO:0071260; GO:0071333; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1902074; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1990785; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN001832	GN001832.1	Q96J94	53.3	763	917	861	9.55e-308	872	PIWL1_HUMAN	Piwi-like protein 1 (EC 3.1.26.-)	Homo sapiens (Human)	piRNA processing [GO:0034587]; piRNA-mediated gene silencing by mRNA destabilization [GO:0140991]; primary piRNA processing [GO:0140990]; regulatory ncRNA-mediated gene silencing [GO:0031047]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006]	mRNA binding [GO:0003729]; mRNA cap binding complex binding [GO:0140262]; piRNA binding [GO:0034584]; protein kinase binding [GO:0019901]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; dense body [GO:0097433]; nucleus [GO:0005634]; P granule [GO:0043186]	GO:0003727; GO:0003729; GO:0004521; GO:0005634; GO:0005737; GO:0007283; GO:0007286; GO:0019901; GO:0031047; GO:0033391; GO:0034584; GO:0034587; GO:0035092; GO:0043186; GO:0097433; GO:0140262; GO:0140990; GO:0140991; GO:0141006
GN001835	GN001835.1	Q16943	55.6	268	255	260	1.23e-72	225	VP33_APLCA	Vesicle-associated membrane protein/synaptobrevin-binding protein (VAP-33)	Aplysia californica (California sea hare)	endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]	FFAT motif binding [GO:0033149]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0005789; GO:0005886; GO:0033149; GO:0045202; GO:0061817; GO:0090158
GN001836	GN001836.1	Q9UJX4	34.6	758	784	755	8.67e-131	410	APC5_HUMAN	Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5)	Homo sapiens (Human)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	protein phosphatase binding [GO:0019903]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0005634; GO:0005654; GO:0005680; GO:0005819; GO:0005829; GO:0007346; GO:0019903; GO:0031145; GO:0045842; GO:0051445; GO:0070936; GO:0070979; GO:0141198
GN001837	GN001837.1	E1BC52	36.5	211	156	207	7.47e-35	123	CF418_BOVIN	Cilia- and flagella-associated protein 418	Bos taurus (Bovine)	photoreceptor cell morphogenesis [GO:0008594]		ciliary base [GO:0097546]; cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917]	GO:0001917; GO:0005737; GO:0008594; GO:0097546
GN001838	GN001838.1	O55135	83.9	242	245	245	1.37e-144	407	IF6_MOUSE	Eukaryotic translation initiation factor 6 (eIF-6) (B4 integrin interactor) (CAB) (p27(BBP))	Mus musculus (Mouse)	assembly of large subunit precursor of preribosome [GO:1902626]; cytosolic ribosome assembly [GO:0042256]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of translation [GO:0045727]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of glycolytic process [GO:0006110]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to insulin [GO:0032868]; ribosomal subunit export from nucleus [GO:0000054]	ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; lamin filament [GO:0005638]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]	GO:0000054; GO:0000460; GO:0000470; GO:0003743; GO:0005634; GO:0005638; GO:0005654; GO:0005730; GO:0005737; GO:0005882; GO:0006110; GO:0032868; GO:0035195; GO:0035278; GO:0042256; GO:0042304; GO:0043022; GO:0043023; GO:0045202; GO:0045652; GO:0045727; GO:1902626; GO:2000377
GN001839	GN001839.1	Q19673	39.5	296	769	693	1.74e-46	180	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN001840	GN001840.1	Q19673	35.8	299	744	693	2.19e-47	182	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN001841	GN001841.1	P22717	38.2	604	592	742	2.53e-119	373	GCYB2_RAT	Guanylate cyclase soluble subunit beta-2 (GCS-beta-2) (EC 4.6.1.2)	Rattus norvegicus (Rat)	intracellular signal transduction [GO:0035556]; response to oxygen levels [GO:0070482]	guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; nitric oxide binding [GO:0070026]	cytosol [GO:0005829]; dendritic knob [GO:0098788]; guanylate cyclase complex, soluble [GO:0008074]	GO:0004383; GO:0005829; GO:0008074; GO:0020037; GO:0035556; GO:0070026; GO:0070482; GO:0098788
GN001844	GN001844.1	Q5XIG0	55.2	288	298	350	7.08e-102	305	NUDT9_RAT	ADP-ribose pyrophosphatase (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9)	Rattus norvegicus (Rat)	ADP catabolic process [GO:0046032]	ADP-ribose diphosphatase activity [GO:0047631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0005737; GO:0005739; GO:0005829; GO:0046032; GO:0047631
GN001846	GN001846.1	Q8SWR3	31.0	348	364	435	6.21e-32	127	SPR_DROME	Sex peptide receptor	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of egg-laying behavior [GO:0046662]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008528; GO:0045434; GO:0046662
GN001849	GN001849.1	F6VAN0	32.7	346	551	656	2.29e-33	138	ATF6A_MOUSE	Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha]	Mus musculus (Mouse)	endoplasmic reticulum unfolded protein response [GO:0030968]; eye development [GO:0001654]; positive regulation of apoptotic process [GO:0043065]; positive regulation of ATF6-mediated unfolded protein response [GO:1903893]; positive regulation of autophagy [GO:0010508]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; visual perception [GO:0007601]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000139; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0001650; GO:0001654; GO:0003700; GO:0005634; GO:0005654; GO:0005730; GO:0005783; GO:0005789; GO:0005794; GO:0006357; GO:0007601; GO:0010508; GO:0016020; GO:0019899; GO:0030968; GO:0031625; GO:0034976; GO:0042802; GO:0043065; GO:0043565; GO:0045944; GO:0046982; GO:0090575; GO:1903893; GO:1990837
GN001850	GN001850.1	A3KNI7	44.3	79	131	344	3.97e-13	67.8	CCDB1_DANRE	Cyclin-D1-binding protein 1 homolog (Zebrafish homolog of Maid)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN001851	GN001851.1	P56812	55.6	126	126	126	2.37e-34	118	PDCD5_MOUSE	Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19)	Mus musculus (Mouse)	apoptotic process [GO:0006915]; cellular response to transforming growth factor beta stimulus [GO:0071560]; negative regulation of protein folding [GO:1903333]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; regulation of apoptotic process [GO:0042981]; T cell activation [GO:0042110]	acetyltransferase activator activity [GO:0010698]; beta-tubulin binding [GO:0048487]; DNA binding [GO:0003677]; heparin binding [GO:0008201]; protein sequestering activity [GO:0140311]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0008201; GO:0010628; GO:0010698; GO:0042110; GO:0042981; GO:0043065; GO:0048487; GO:0071560; GO:0140311; GO:1901798; GO:1902255; GO:1903333
GN001854	GN001854.1	P15989	34.5	206	409	3137	6.88e-24	108	CO6A3_CHICK	Collagen alpha-3(VI) chain	Gallus gallus (Chicken)		serine-type endopeptidase inhibitor activity [GO:0004867]	collagen type VI trimer [GO:0005589]	GO:0004867; GO:0005589
GN001855	GN001855.1	Q9D411	46.9	294	326	328	4.74e-89	272	TSSK4_MOUSE	Testis-specific serine/threonine-protein kinase 4 (TSK-4) (TSSK-4) (Testis-specific kinase 4) (EC 2.7.11.1)	Mus musculus (Mouse)	fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]	GO:0000287; GO:0001669; GO:0004672; GO:0004674; GO:0005524; GO:0006468; GO:0007286; GO:0009566; GO:0030317; GO:0031514; GO:0036126; GO:0042802; GO:0042803; GO:0044877; GO:0106310
GN001856	GN001856.1	Q9BSE4	34.8	411	384	406	1.32e-49	175	HERP2_HUMAN	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	Homo sapiens (Human)	endoplasmic reticulum unfolded protein response [GO:0030968]; spermatogenesis [GO:0007283]		membrane [GO:0016020]	GO:0007283; GO:0016020; GO:0030968
GN001858	GN001858.1	A9CJC9	35.7	465	553	479	7.28e-78	256	PHRA_AGRFC	Deoxyribodipyrimidine photo-lyase (EC 4.1.99.3) (Cyclobutane pyrimidine dimer photolyase) (CPD photolyase) (DNA photolyase PhrA) (Photoreactivating enzyme PhrA)	Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))	photoreactive repair [GO:0000719]; response to light stimulus [GO:0009416]	deoxyribodipyrimidine photo-lyase activity [GO:0003904]; DNA binding [GO:0003677]; FAD binding [GO:0071949]		GO:0000719; GO:0003677; GO:0003904; GO:0009416; GO:0071949
GN001859	GN001859.1	Q8SWR3	27.7	318	359	435	1.78e-17	86.7	SPR_DROME	Sex peptide receptor	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of egg-laying behavior [GO:0046662]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008528; GO:0045434; GO:0046662
GN001863	GN001863.1	Q8SWR3	31.0	348	364	435	6.21e-32	127	SPR_DROME	Sex peptide receptor	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of egg-laying behavior [GO:0046662]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008528; GO:0045434; GO:0046662
GN001868	GN001868.1	Q9H0J9	30.1	658	1019	701	2.46e-65	237	PAR12_HUMAN	Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1)	Homo sapiens (Human)	protein auto-ADP-ribosylation [GO:0070213]; transepithelial transport [GO:0070633]	metal ion binding [GO:0046872]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; RNA binding [GO:0003723]	cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]	GO:0003723; GO:0003950; GO:0005634; GO:0005802; GO:0010494; GO:0046872; GO:0070213; GO:0070633; GO:0140803; GO:0140806; GO:1990404
GN001869	GN001869.1	Q9H0J9	30.3	706	1117	701	4.15e-64	234	PAR12_HUMAN	Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1)	Homo sapiens (Human)	protein auto-ADP-ribosylation [GO:0070213]; transepithelial transport [GO:0070633]	metal ion binding [GO:0046872]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; RNA binding [GO:0003723]	cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]	GO:0003723; GO:0003950; GO:0005634; GO:0005802; GO:0010494; GO:0046872; GO:0070213; GO:0070633; GO:0140803; GO:0140806; GO:1990404
GN001870	GN001870.1	Q0VCP9	48.6	296	628	319	3.29e-74	243	CC149_BOVIN	Coiled-coil domain-containing protein 149	Bos taurus (Bovine)			membrane [GO:0016020]	GO:0016020
GN001871	GN001871.1	Q9ES03	61.0	331	457	445	4.74e-126	376	TBX20_MOUSE	T-box transcription factor TBX20 (T-box protein 20)	Mus musculus (Mouse)	aortic valve development [GO:0003176]; aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; atrioventricular canal development [GO:0036302]; atrioventricular valve development [GO:0003171]; blood circulation [GO:0008015]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac chamber formation [GO:0003207]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum development [GO:0003279]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube development [GO:0035050]; embryonic heart tube elongation [GO:0036306]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; foramen ovale closure [GO:0035922]; heart looping [GO:0001947]; mesenchymal cell development [GO:0014031]; muscle contraction [GO:0006936]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle process [GO:0090068]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary valve formation [GO:0003193]; pulmonary vein morphogenesis [GO:0060577]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of transcription by RNA polymerase II [GO:0006357]; tricuspid valve development [GO:0003175]; visceral motor neuron differentiation [GO:0021524]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0001569; GO:0001708; GO:0001764; GO:0001947; GO:0003143; GO:0003148; GO:0003151; GO:0003171; GO:0003175; GO:0003176; GO:0003180; GO:0003193; GO:0003203; GO:0003207; GO:0003215; GO:0003272; GO:0003279; GO:0003344; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0006936; GO:0008015; GO:0008283; GO:0009953; GO:0010717; GO:0010718; GO:0014031; GO:0021524; GO:0030513; GO:0035050; GO:0035922; GO:0036302; GO:0036306; GO:0043065; GO:0045892; GO:0045893; GO:0045944; GO:0055008; GO:0060045; GO:0060392; GO:0060413; GO:0060577; GO:0061629; GO:0090068; GO:1990837
GN001873	GN001873.1	Q9ES03	57.3	337	422	445	2.98e-112	339	TBX20_MOUSE	T-box transcription factor TBX20 (T-box protein 20)	Mus musculus (Mouse)	aortic valve development [GO:0003176]; aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; atrioventricular canal development [GO:0036302]; atrioventricular valve development [GO:0003171]; blood circulation [GO:0008015]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac chamber formation [GO:0003207]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum development [GO:0003279]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube development [GO:0035050]; embryonic heart tube elongation [GO:0036306]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; foramen ovale closure [GO:0035922]; heart looping [GO:0001947]; mesenchymal cell development [GO:0014031]; muscle contraction [GO:0006936]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle process [GO:0090068]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary valve formation [GO:0003193]; pulmonary vein morphogenesis [GO:0060577]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of transcription by RNA polymerase II [GO:0006357]; tricuspid valve development [GO:0003175]; visceral motor neuron differentiation [GO:0021524]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0001569; GO:0001708; GO:0001764; GO:0001947; GO:0003143; GO:0003148; GO:0003151; GO:0003171; GO:0003175; GO:0003176; GO:0003180; GO:0003193; GO:0003203; GO:0003207; GO:0003215; GO:0003272; GO:0003279; GO:0003344; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0006936; GO:0008015; GO:0008283; GO:0009953; GO:0010717; GO:0010718; GO:0014031; GO:0021524; GO:0030513; GO:0035050; GO:0035922; GO:0036302; GO:0036306; GO:0043065; GO:0045892; GO:0045893; GO:0045944; GO:0055008; GO:0060045; GO:0060392; GO:0060413; GO:0060577; GO:0061629; GO:0090068; GO:1990837
GN001876	GN001876.1	Q9P2R6	38.2	374	854	1566	7.29e-15	83.2	RERE_HUMAN	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein)	Homo sapiens (Human)		chromatin binding [GO:0003682]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	histone deacetylase complex [GO:0000118]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000118; GO:0003682; GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0016604; GO:0043565
GN001879	GN001879.1	P26221	50.5	444	550	880	1.62e-133	412	GUN4_THEFU	Endoglucanase E-4 (EC 3.2.1.4) (Cellulase E-4) (Cellulase E4) (Endo-1,4-beta-glucanase E-4)	Thermobifida fusca (Thermomonospora fusca)	cellulose catabolic process [GO:0030245]	cellulase activity [GO:0008810]; cellulose binding [GO:0030248]		GO:0008810; GO:0030245; GO:0030248
GN001881	GN001881.1	Q9H7H0	31.7	426	516	456	3.93e-63	216	MET17_HUMAN	Ribosome assembly protein METTL17, mitochondrial (False p73 target gene protein) (Methyltransferase 11 domain-containing protein 1) (Methyltransferase-like protein 17) (Protein RSM22 homolog, mitochondrial)	Homo sapiens (Human)	mitochondrial small ribosomal subunit assembly [GO:0180026]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	4 iron, 4 sulfur cluster binding [GO:0051539]; mitochondrial ribosome binding [GO:0097177]; S-adenosyl-L-methionine binding [GO:1904047]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005739; GO:0005759; GO:0006412; GO:0042274; GO:0051539; GO:0097177; GO:0180026; GO:1904047
GN001882	GN001882.1	Q55EX9	30.9	223	246	263	8.66e-31	117	Y8948_DICDI	Putative methyltransferase DDB_G0268948 (EC 2.1.1.-)	Dictyostelium discoideum (Social amoeba)		S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	phagocytic vesicle [GO:0045335]	GO:0008757; GO:0045335
GN001884	GN001884.1	Q55EX9	32.0	253	258	263	2.14e-36	132	Y8948_DICDI	Putative methyltransferase DDB_G0268948 (EC 2.1.1.-)	Dictyostelium discoideum (Social amoeba)		S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	phagocytic vesicle [GO:0045335]	GO:0008757; GO:0045335
GN001889	GN001889.1	Q9W436	42.8	685	817	849	1.82e-192	573	NEP_DROME	Neprilysin-1 (EC 3.4.24.11)	Drosophila melanogaster (Fruit fly)	proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004222; GO:0005886; GO:0006508; GO:0008237; GO:0016020
GN001890	GN001890.1	Q8R5F7	29.2	764	1158	1025	2.82e-58	222	IFIH1_MOUSE	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Helicase with 2 CARD domains) (Helicard) (Interferon induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (RIG-I-like receptor 2) (RLR-2)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; mRNA transcription [GO:0009299]; negative regulation of viral genome replication [GO:0045071]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of tumor necrosis factor production [GO:0032760]; protein complex oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; protein domain specific binding [GO:0019904]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0003677; GO:0003723; GO:0003724; GO:0003725; GO:0003727; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0008270; GO:0009299; GO:0009615; GO:0016887; GO:0016925; GO:0019904; GO:0032727; GO:0032728; GO:0032755; GO:0032760; GO:0038187; GO:0039530; GO:0042802; GO:0043021; GO:0045071; GO:0045087; GO:0051259; GO:0051607; GO:0060337; GO:0060760; GO:0071360; GO:0098586; GO:0140374
GN001891	GN001891.1	A3KQ55	39.5	564	651	645	3.65e-100	322	MEPCE_DANRE	7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) (zBCDIN3)	Danio rerio (Zebrafish) (Brachydanio rerio)	positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; RNA methylation [GO:0001510]; snRNA metabolic process [GO:0016073]; snRNA modification [GO:0040031]	O-methyltransferase activity [GO:0008171]; RNA 5'-gamma-phosphate methyltransferase activity [GO:1990276]; RNA methyltransferase activity [GO:0008173]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; snRNA binding [GO:0017069]	nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0001510; GO:0005634; GO:0008171; GO:0008173; GO:0008757; GO:0016073; GO:0017069; GO:0040031; GO:1904871; GO:1905382; GO:1990276; GO:1990904
GN001892	GN001892.1	Q8K4Q8	30.2	149	542	742	5.50e-10	65.9	COL12_MOUSE	Collectin-12 (Collectin placenta protein 1) (CL-P1) (Scavenger receptor with C-type lectin)	Mus musculus (Mouse)	defense response to bacterium [GO:0042742]; immune response [GO:0006955]; phagocytosis, recognition [GO:0006910]	carbohydrate binding [GO:0030246]; low-density lipoprotein particle binding [GO:0030169]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]	extracellular matrix [GO:0031012]; membrane [GO:0016020]	GO:0005044; GO:0006910; GO:0006955; GO:0016020; GO:0030169; GO:0030246; GO:0031012; GO:0038187; GO:0042742
GN001894	GN001894.1	A2ASQ1	35.1	427	422	1950	1.78e-67	236	AGRIN_MOUSE	Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]	Mus musculus (Mouse)	cell surface receptor signaling pathway [GO:0007166]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; circadian rhythm [GO:0007623]; enzyme-linked receptor protein signaling pathway [GO:0007167]; filopodium assembly [GO:0046847]; negative regulation of sodium ion export across plasma membrane [GO:1903277]; nervous system development [GO:0007399]; neuromuscular junction development [GO:0007528]; plasma membrane organization [GO:0007009]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein binding [GO:0032092]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; positive regulation of synaptic assembly at neuromuscular junction [GO:0045887]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; receptor clustering [GO:0043113]; regulation of axon guidance [GO:1902667]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of synapse organization [GO:0050807]; regulation of synaptic activity [GO:0060025]; signal transduction [GO:0007165]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse assembly [GO:0007416]	acetylcholine receptor regulator activity [GO:0030548]; ATPase inhibitor activity [GO:0042030]; BMP binding [GO:0036122]; calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; dystroglycan binding [GO:0002162]; heparan sulfate proteoglycan binding [GO:0043395]; receptor ligand activity [GO:0048018]; sialic acid binding [GO:0033691]; transforming growth factor beta binding [GO:0050431]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; transmembrane transporter binding [GO:0044325]; transporter inhibitor activity [GO:0141110]	axonal growth cone [GO:0044295]; basement membrane [GO:0005604]; cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; gel phase of basement membrane [GO:0140148]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; synapse [GO:0045202]	GO:0002062; GO:0002162; GO:0005509; GO:0005576; GO:0005604; GO:0005796; GO:0005886; GO:0007009; GO:0007165; GO:0007166; GO:0007167; GO:0007268; GO:0007399; GO:0007416; GO:0007528; GO:0007623; GO:0009986; GO:0015031; GO:0030297; GO:0030548; GO:0031012; GO:0032092; GO:0033691; GO:0035022; GO:0035374; GO:0036122; GO:0042030; GO:0042383; GO:0043113; GO:0043395; GO:0043525; GO:0044295; GO:0044325; GO:0045202; GO:0045887; GO:0045944; GO:0046847; GO:0048018; GO:0050431; GO:0050807; GO:0051491; GO:0055117; GO:0060025; GO:0070507; GO:0071340; GO:0086036; GO:0098978; GO:0140148; GO:0141110; GO:1902667; GO:1903277; GO:1904395
GN001896	GN001896.1	A2ASQ1	24.2	1132	872	1950	7.71e-81	289	AGRIN_MOUSE	Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]	Mus musculus (Mouse)	cell surface receptor signaling pathway [GO:0007166]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; circadian rhythm [GO:0007623]; enzyme-linked receptor protein signaling pathway [GO:0007167]; filopodium assembly [GO:0046847]; negative regulation of sodium ion export across plasma membrane [GO:1903277]; nervous system development [GO:0007399]; neuromuscular junction development [GO:0007528]; plasma membrane organization [GO:0007009]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein binding [GO:0032092]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; positive regulation of synaptic assembly at neuromuscular junction [GO:0045887]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; receptor clustering [GO:0043113]; regulation of axon guidance [GO:1902667]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of synapse organization [GO:0050807]; regulation of synaptic activity [GO:0060025]; signal transduction [GO:0007165]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse assembly [GO:0007416]	acetylcholine receptor regulator activity [GO:0030548]; ATPase inhibitor activity [GO:0042030]; BMP binding [GO:0036122]; calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; dystroglycan binding [GO:0002162]; heparan sulfate proteoglycan binding [GO:0043395]; receptor ligand activity [GO:0048018]; sialic acid binding [GO:0033691]; transforming growth factor beta binding [GO:0050431]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; transmembrane transporter binding [GO:0044325]; transporter inhibitor activity [GO:0141110]	axonal growth cone [GO:0044295]; basement membrane [GO:0005604]; cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; gel phase of basement membrane [GO:0140148]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; synapse [GO:0045202]	GO:0002062; GO:0002162; GO:0005509; GO:0005576; GO:0005604; GO:0005796; GO:0005886; GO:0007009; GO:0007165; GO:0007166; GO:0007167; GO:0007268; GO:0007399; GO:0007416; GO:0007528; GO:0007623; GO:0009986; GO:0015031; GO:0030297; GO:0030548; GO:0031012; GO:0032092; GO:0033691; GO:0035022; GO:0035374; GO:0036122; GO:0042030; GO:0042383; GO:0043113; GO:0043395; GO:0043525; GO:0044295; GO:0044325; GO:0045202; GO:0045887; GO:0045944; GO:0046847; GO:0048018; GO:0050431; GO:0050807; GO:0051491; GO:0055117; GO:0060025; GO:0070507; GO:0071340; GO:0086036; GO:0098978; GO:0140148; GO:0141110; GO:1902667; GO:1903277; GO:1904395
GN001897	GN001897.1	Q20929	28.4	352	376	510	2.38e-30	124	DMSR1_CAEEL	G protein-coupled receptor dmsr-1 (Dromyosuppressin receptor related 1)	Caenorhabditis elegans	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of cellular response to heat [GO:1900034]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008188; GO:0008528; GO:0032809; GO:0045187; GO:1900034
GN001902	GN001902.1	Q8UVK2	56.0	216	469	1726	9.23e-67	236	SPT6H_DANRE	Transcription elongation factor SPT6 (Protein pandora)	Danio rerio (Zebrafish) (Brachydanio rerio)	embryonic heart tube development [GO:0035050]; heart development [GO:0007507]; nucleosome organization [GO:0034728]; otic vesicle development [GO:0071599]; somitogenesis [GO:0001756]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673]	DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]	transcription elongation factor complex [GO:0008023]	GO:0001756; GO:0003677; GO:0006368; GO:0007507; GO:0008023; GO:0031491; GO:0034728; GO:0035050; GO:0042393; GO:0071599; GO:0140673
GN001903	GN001903.1	Q7KZ85	60.0	1286	1390	1726	0.0	1491	SPT6H_HUMAN	Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)	Homo sapiens (Human)	nucleosome organization [GO:0034728]; regulation of isotype switching [GO:0045191]; regulation of muscle cell differentiation [GO:0051147]; transcription elongation by RNA polymerase II [GO:0006368]; transcription elongation-coupled chromatin remodeling [GO:0140673]	DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]	GO:0003677; GO:0003723; GO:0005654; GO:0006368; GO:0008023; GO:0031491; GO:0034728; GO:0042393; GO:0045191; GO:0051147; GO:0140673
GN001904	GN001904.1	Q96I34	40.1	322	687	528	5.14e-62	219	PP16A_HUMAN	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3)	Homo sapiens (Human)		enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004857; GO:0005737; GO:0005886; GO:0017020
GN001906	GN001906.1	Q9VLS1	44.9	176	189	1093	4.48e-40	147	KPBB_DROME	Probable phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta)	Drosophila melanogaster (Fruit fly)	glycogen metabolic process [GO:0005977]; positive regulation of glycogen catabolic process [GO:0045819]	calmodulin binding [GO:0005516]	phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886]	GO:0005516; GO:0005886; GO:0005964; GO:0005977; GO:0045819
GN001907	GN001907.1	Q9VLS1	78.8	66	70	1093	1.84e-28	108	KPBB_DROME	Probable phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta)	Drosophila melanogaster (Fruit fly)	glycogen metabolic process [GO:0005977]; positive regulation of glycogen catabolic process [GO:0045819]	calmodulin binding [GO:0005516]	phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886]	GO:0005516; GO:0005886; GO:0005964; GO:0005977; GO:0045819
GN001908	GN001908.1	Q7TSH2	51.4	868	863	1085	4.53e-301	862	KPBB_MOUSE	Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta)	Mus musculus (Mouse)	glucose homeostasis [GO:0042593]; glycogen catabolic process [GO:0005980]; positive regulation of glycogen catabolic process [GO:0045819]; protein phosphorylation [GO:0006468]	calmodulin binding [GO:0005516]	phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886]	GO:0005516; GO:0005886; GO:0005964; GO:0005980; GO:0006468; GO:0042593; GO:0045819
GN001910	GN001910.1	Q99J25	34.8	135	228	320	1.54e-15	77.4	MRM1_MOUSE	rRNA methyltransferase 1, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1145)-2'-O)-methyltransferase) (16S rRNA [Gm1145] 2'-O-methyltransferase)	Mus musculus (Mouse)	rRNA modification [GO:0000154]; rRNA processing [GO:0006364]	RNA binding [GO:0003723]; rRNA (guanine) methyltransferase activity [GO:0016435]; rRNA (guanosine-2'-O-ribose)-methyltransferase activity [GO:0070039]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0000154; GO:0003723; GO:0005739; GO:0005759; GO:0006364; GO:0016435; GO:0070039
GN001913	GN001913.1	Q9Y2E6	40.0	663	639	619	4.63e-128	394	DTX4_HUMAN	E3 ubiquitin-protein ligase DTX4 (EC 2.3.2.27) (Protein deltex-4) (Deltex4) (RING finger protein 155) (RING-type E3 ubiquitin transferase DTX4)	Homo sapiens (Human)	negative regulation of innate immune response [GO:0045824]; Notch signaling pathway [GO:0007219]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of type I interferon production [GO:0032479]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0004842; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0007219; GO:0008270; GO:0010498; GO:0016567; GO:0032479; GO:0043161; GO:0045824; GO:0061630; GO:0070936
GN001914	GN001914.1	P51810	25.6	246	365	404	9.16e-20	93.2	GP143_HUMAN	G protein-coupled receptor 143 (Ocular albinism type 1 protein)	Homo sapiens (Human)	eye pigment biosynthetic process [GO:0006726]; G protein-coupled receptor signaling pathway [GO:0007186]; melanosome localization [GO:0032400]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of melanosome organization [GO:1903056]; regulation of melanosome transport [GO:1902908]; signal transduction [GO:0007165]; visual perception [GO:0007601]	dopamine binding [GO:0035240]; G protein-coupled receptor activity [GO:0004930]; L-DOPA binding [GO:0072544]; L-DOPA receptor activity [GO:0035643]; L-tyrosine binding [GO:0072545]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004930; GO:0005737; GO:0005765; GO:0005794; GO:0005886; GO:0006726; GO:0007165; GO:0007186; GO:0007200; GO:0007601; GO:0016020; GO:0016324; GO:0032400; GO:0032402; GO:0032438; GO:0033162; GO:0035240; GO:0035643; GO:0042470; GO:0072544; GO:0072545; GO:1902908; GO:1903056
GN001915	GN001915.1	Q6P2Q9	89.1	256	256	2335	5.87e-156	482	PRP8_HUMAN	Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)	Homo sapiens (Human)	cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [GO:0000388]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; RNA binding [GO:0003723]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type catalytic step 2 spliceosome [GO:0071018]; U12-type precatalytic spliceosome [GO:0071016]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac/U6atac x U5 tri-snRNP complex [GO:0071009]; U5 snRNP [GO:0005682]	GO:0000244; GO:0000375; GO:0000387; GO:0000388; GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005682; GO:0006397; GO:0008380; GO:0016020; GO:0016607; GO:0017070; GO:0030623; GO:0045292; GO:0046540; GO:0048025; GO:0070530; GO:0071005; GO:0071006; GO:0071007; GO:0071009; GO:0071011; GO:0071013; GO:0071014; GO:0071016; GO:0071018; GO:0071020; GO:0071222; GO:0071356
GN001916	GN001916.1	Q6P2Q9	96.0	252	276	2335	4.97e-163	503	PRP8_HUMAN	Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)	Homo sapiens (Human)	cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [GO:0000388]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; RNA binding [GO:0003723]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type catalytic step 2 spliceosome [GO:0071018]; U12-type precatalytic spliceosome [GO:0071016]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac/U6atac x U5 tri-snRNP complex [GO:0071009]; U5 snRNP [GO:0005682]	GO:0000244; GO:0000375; GO:0000387; GO:0000388; GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005682; GO:0006397; GO:0008380; GO:0016020; GO:0016607; GO:0017070; GO:0030623; GO:0045292; GO:0046540; GO:0048025; GO:0070530; GO:0071005; GO:0071006; GO:0071007; GO:0071009; GO:0071011; GO:0071013; GO:0071014; GO:0071016; GO:0071018; GO:0071020; GO:0071222; GO:0071356
GN001917	GN001917.1	Q6P2Q9	92.8	861	862	2335	0.0	1633	PRP8_HUMAN	Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)	Homo sapiens (Human)	cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [GO:0000388]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; RNA binding [GO:0003723]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type catalytic step 2 spliceosome [GO:0071018]; U12-type precatalytic spliceosome [GO:0071016]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac/U6atac x U5 tri-snRNP complex [GO:0071009]; U5 snRNP [GO:0005682]	GO:0000244; GO:0000375; GO:0000387; GO:0000388; GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005682; GO:0006397; GO:0008380; GO:0016020; GO:0016607; GO:0017070; GO:0030623; GO:0045292; GO:0046540; GO:0048025; GO:0070530; GO:0071005; GO:0071006; GO:0071007; GO:0071009; GO:0071011; GO:0071013; GO:0071014; GO:0071016; GO:0071018; GO:0071020; GO:0071222; GO:0071356
GN001919	GN001919.1	P57772	56.5	595	554	596	5.94e-223	632	SELB_HUMAN	Selenocysteine-specific elongation factor (EC 3.6.5.-) (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific)	Homo sapiens (Human)	selenium compound metabolic process [GO:0001887]; selenocysteine incorporation [GO:0001514]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribonucleoprotein complex binding [GO:0043021]; selenocysteine insertion sequence binding [GO:0035368]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049]	cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0000049; GO:0001514; GO:0001887; GO:0003746; GO:0003924; GO:0005525; GO:0005634; GO:0005829; GO:0035368; GO:0043021; GO:1990904
GN001920	GN001920.1	Q7ZV00	40.8	304	305	293	2.26e-64	207	OTU6B_DANRE	Deubiquitinase OTUD6B (EC 3.4.19.12)	Danio rerio (Zebrafish) (Brachydanio rerio)	antiviral innate immune response [GO:0140374]; protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]		GO:0004843; GO:0016579; GO:0140374
GN001921	GN001921.1	Q6NYE7	31.1	270	263	271	1.98e-26	107	TM192_DANRE	Transmembrane protein 192	Danio rerio (Zebrafish) (Brachydanio rerio)			late endosome [GO:0005770]; lysosomal membrane [GO:0005765]	GO:0005765; GO:0005770
GN001922	GN001922.1	P97697	50.0	260	274	277	2.03e-85	259	IMPA1_RAT	Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1)	Rattus norvegicus (Rat)	inositol biosynthetic process [GO:0006021]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; signal transduction [GO:0007165]	fructose-1-phosphatase activity [GO:0103026]; glucose-1-phosphatase activity [GO:0008877]; glucose-6-phosphatase activity [GO:0004346]; glycerol-2-phosphatase activity [GO:0047954]; identical protein binding [GO:0042802]; inositol monophosphate 1-phosphatase activity [GO:0008934]; inositol monophosphate 3-phosphatase activity [GO:0052832]; inositol monophosphate 4-phosphatase activity [GO:0052833]; inositol monophosphate phosphatase activity [GO:0052834]; lithium ion binding [GO:0031403]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]	GO:0000287; GO:0004346; GO:0005737; GO:0006021; GO:0006661; GO:0006796; GO:0007165; GO:0008877; GO:0008934; GO:0030145; GO:0030424; GO:0031403; GO:0042802; GO:0042803; GO:0043025; GO:0046854; GO:0047954; GO:0052832; GO:0052833; GO:0052834; GO:0103026
GN001923	GN001923.1	Q90VV1	42.0	281	274	277	8.53e-45	155	HES4B_XENLA	Transcription factor HES-4-B (Hairy and enhancer of split 4-B) (Protein hairy-2) (Xhairy2) (Protein hairy-2a) (Xhairy2b)	Xenopus laevis (African clawed frog)	anterior/posterior pattern specification [GO:0009952]; floor plate development [GO:0033504]; lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest formation [GO:0014029]; prechordal plate formation [GO:0021501]; regulation of neurogenesis [GO:0050767]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0002088; GO:0005634; GO:0009952; GO:0014029; GO:0021501; GO:0033504; GO:0043066; GO:0043565; GO:0045892; GO:0046982; GO:0048642; GO:0050767
GN001924	GN001924.1	O57337	55.5	155	321	290	9.16e-44	154	HES1_CHICK	Transcription factor HES-1 (C-HAIRY1) (Hairy and enhancer of split 1)	Gallus gallus (Chicken)	anterior/posterior pattern specification [GO:0009952]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of neurogenesis [GO:0050767]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0005634; GO:0009952; GO:0042803; GO:0045665; GO:0046982; GO:0050767
GN001925	GN001925.1	Q8AVU4	45.5	121	332	267	8.39e-15	76.6	HES1B_XENLA	Transcription factor HES-1-B (Hairy and enhancer of split 1-B)	Xenopus laevis (African clawed frog)	anterior/posterior pattern specification [GO:0009952]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of muscle organ development [GO:0048635]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; regulation of neurogenesis [GO:0050767]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0005634; GO:0007219; GO:0009952; GO:0043425; GO:0045665; GO:0045892; GO:0046982; GO:0048635; GO:0050767
GN001926	GN001926.1	P53988	25.5	326	338	484	5.61e-22	99.8	MOT2_MESAU	Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)	Mesocricetus auratus (Golden hamster)	lactate transmembrane transport [GO:0035873]; plasma membrane lactate transport [GO:0035879]; pyruvate transmembrane transport [GO:1901475]	identical protein binding [GO:0042802]; lactate transmembrane transporter activity [GO:0015129]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0015129; GO:0015293; GO:0016323; GO:0035873; GO:0035879; GO:0042802; GO:0050833; GO:1901475
GN001927	GN001927.1	P53988	27.5	302	296	484	1.29e-12	71.2	MOT2_MESAU	Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)	Mesocricetus auratus (Golden hamster)	lactate transmembrane transport [GO:0035873]; plasma membrane lactate transport [GO:0035879]; pyruvate transmembrane transport [GO:1901475]	identical protein binding [GO:0042802]; lactate transmembrane transporter activity [GO:0015129]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0015129; GO:0015293; GO:0016323; GO:0035873; GO:0035879; GO:0042802; GO:0050833; GO:1901475
GN001928	GN001928.1	P53988	26.9	360	353	484	1.11e-20	96.3	MOT2_MESAU	Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)	Mesocricetus auratus (Golden hamster)	lactate transmembrane transport [GO:0035873]; plasma membrane lactate transport [GO:0035879]; pyruvate transmembrane transport [GO:1901475]	identical protein binding [GO:0042802]; lactate transmembrane transporter activity [GO:0015129]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0015129; GO:0015293; GO:0016323; GO:0035873; GO:0035879; GO:0042802; GO:0050833; GO:1901475
GN001929	GN001929.1	P53988	26.4	360	374	484	1.83e-21	99.0	MOT2_MESAU	Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)	Mesocricetus auratus (Golden hamster)	lactate transmembrane transport [GO:0035873]; plasma membrane lactate transport [GO:0035879]; pyruvate transmembrane transport [GO:1901475]	identical protein binding [GO:0042802]; lactate transmembrane transporter activity [GO:0015129]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0015129; GO:0015293; GO:0016323; GO:0035873; GO:0035879; GO:0042802; GO:0050833; GO:1901475
GN001930	GN001930.1	P53988	24.9	341	398	484	3.08e-22	101	MOT2_MESAU	Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)	Mesocricetus auratus (Golden hamster)	lactate transmembrane transport [GO:0035873]; plasma membrane lactate transport [GO:0035879]; pyruvate transmembrane transport [GO:1901475]	identical protein binding [GO:0042802]; lactate transmembrane transporter activity [GO:0015129]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0015129; GO:0015293; GO:0016323; GO:0035873; GO:0035879; GO:0042802; GO:0050833; GO:1901475
GN001932	GN001932.1	Q66JG2	32.4	170	163	215	5.55e-22	90.9	CPTP_XENTR	Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1) (CPTP)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	ceramide 1-phosphate transport [GO:1902389]; ceramide transport [GO:0035627]; intermembrane lipid transfer [GO:0120009]; negative regulation of autophagy [GO:0010507]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]	ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]	GO:0005543; GO:0005640; GO:0005794; GO:0005829; GO:0005886; GO:0010008; GO:0010507; GO:0032691; GO:0035627; GO:0120009; GO:1900226; GO:1902387; GO:1902388; GO:1902389
GN001933	GN001933.1	Q6DBQ8	36.7	207	215	211	7.44e-44	149	CPTP_DANRE	Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1) (CPTP)	Danio rerio (Zebrafish) (Brachydanio rerio)	ceramide 1-phosphate transport [GO:1902389]; ceramide transport [GO:0035627]; intermembrane lipid transfer [GO:0120009]; negative regulation of autophagy [GO:0010507]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]	ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]	GO:0005543; GO:0005640; GO:0005794; GO:0005829; GO:0005886; GO:0010008; GO:0010507; GO:0032691; GO:0035627; GO:0120009; GO:1900226; GO:1902387; GO:1902388; GO:1902389
GN001934	GN001934.1	Q6ZQI3	53.7	136	160	291	1.39e-36	130	MLEC_MOUSE	Malectin	Mus musculus (Mouse)		carbohydrate binding [GO:0030246]; enzyme binding [GO:0019899]; protein-folding chaperone binding [GO:0051087]	endoplasmic reticulum [GO:0005783]; oligosaccharyltransferase complex [GO:0008250]	GO:0005783; GO:0008250; GO:0019899; GO:0030246; GO:0051087
GN001935	GN001935.1	Q503M4	24.4	258	271	477	2.65e-13	72.8	MT12B_DANRE	Monocarboxylate transporter 12-B (MCT 12-B) (Solute carrier family 16 member 12-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; transmembrane transporter activity [GO:0022857]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0022857; GO:0046449
GN001936	GN001936.1	Q92620	61.7	1245	1236	1227	0.0	1387	PRP16_HUMAN	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38)	Homo sapiens (Human)	mRNA splicing, via spliceosome [GO:0000398]	3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0000398; GO:0003723; GO:0003724; GO:0005524; GO:0005634; GO:0005654; GO:0005681; GO:0016020; GO:0016887; GO:0034458; GO:0071006; GO:0071013
GN001937	GN001937.1	O08654	61.1	419	423	422	7.48e-186	526	PHAF1_RAT	Phagosome assembly factor 1	Rattus norvegicus (Rat)	Golgi to plasma membrane protein transport [GO:0043001]	glutamate receptor binding [GO:0035254]; PDZ domain binding [GO:0030165]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; phagophore assembly site [GO:0000407]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]	GO:0000407; GO:0005737; GO:0005802; GO:0030165; GO:0030425; GO:0030672; GO:0035254; GO:0043001
GN001938	GN001938.1	Q6IQ73	65.9	223	223	224	7.64e-87	259	CHM4C_DANRE	Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; negative regulation of cytokinesis [GO:0032466]; nuclear membrane reassembly [GO:0031468]		cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; late endosome membrane [GO:0031902]; nuclear envelope [GO:0005635]	GO:0000815; GO:0005635; GO:0005829; GO:0009898; GO:0031468; GO:0031902; GO:0032466; GO:0032511; GO:0044878; GO:0060271; GO:0061952
GN001939	GN001939.1	Q02369	45.8	118	158	179	1.82e-20	85.9	NDUB9_BOVIN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (CI-B22) (NADH-ubiquinone oxidoreductase B22 subunit)	Bos taurus (Bovine)	mitochondrial electron transport, NADH to ubiquinone [GO:0006120]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271]	GO:0005739; GO:0005743; GO:0006120; GO:0045271
GN001940	GN001940.1	Q92766	66.7	45	212	1687	3.82e-10	62.4	RREB1_HUMAN	Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0000122; GO:0000977; GO:0000978; GO:0001228; GO:0005634; GO:0005737; GO:0006355; GO:0006357; GO:0006366; GO:0010634; GO:0016604; GO:0016607; GO:0033601; GO:0045893; GO:0045944; GO:0070062; GO:0090336; GO:1900026; GO:1903691; GO:2000394
GN001941	GN001941.1	Q8NCC3	48.0	373	381	412	1.18e-124	368	PAG15_HUMAN	Lysosomal phospholipase A and acyltransferase (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) (Phospholipase A2 group XV) (PLA2G15)	Homo sapiens (Human)	ceramide metabolic process [GO:0006672]; diacylglycerol biosynthetic process [GO:0006651]; fatty acid catabolic process [GO:0009062]; glycerophospholipid metabolic process [GO:0006650]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine catabolic process [GO:0046338]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644]	A2-type glycerophospholipase activity [GO:0004623]; acylglycerol O-acyltransferase activity [GO:0016411]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; glycerophospholipid phospholipase A1 activity [GO:0008970]; phosphatidylcholine lysophospholipase A1 activity [GO:0004622]; phospholipid binding [GO:0005543]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosome [GO:0005764]; membrane [GO:0016020]	GO:0004622; GO:0004623; GO:0005543; GO:0005576; GO:0005764; GO:0006644; GO:0006650; GO:0006651; GO:0006658; GO:0006672; GO:0008270; GO:0008970; GO:0009062; GO:0016020; GO:0016411; GO:0016747; GO:0034638; GO:0046338; GO:0046470; GO:0046471; GO:0070062
GN001949	GN001949.1	Q8TCX5	46.9	565	666	670	1.51e-157	472	RHPN1_HUMAN	Rhophilin-1 (GTP-Rho-binding protein 1)	Homo sapiens (Human)	negative regulation of stress fiber assembly [GO:0051497]; signal transduction [GO:0007165]		cytosol [GO:0005829]	GO:0005829; GO:0007165; GO:0051497
GN001950	GN001950.1	Q9P2T1	77.4	283	289	348	2.88e-161	455	GMPR2_HUMAN	GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)	Homo sapiens (Human)	GMP metabolic process [GO:0046037]	GMP reductase activity [GO:0003920]	cytosol [GO:0005829]; GMP reductase complex [GO:1902560]	GO:0003920; GO:0005829; GO:0046037; GO:1902560
GN001951	GN001951.1	P57709	64.6	898	904	953	0.0	1107	AT2C1_BOVIN	Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1)	Bos taurus (Bovine)	actin cytoskeleton organization [GO:0030036]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-dependent cell-cell adhesion [GO:0016339]; epidermis development [GO:0008544]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; intracellular calcium ion homeostasis [GO:0006874]; intracellular manganese ion homeostasis [GO:0030026]; manganese ion transport [GO:0006828]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; trans-Golgi network membrane organization [GO:0098629]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; manganese ion binding [GO:0030145]; P-type calcium transporter activity [GO:0005388]; P-type manganese transporter activity [GO:0140613]	cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0005388; GO:0005509; GO:0005524; GO:0005783; GO:0005794; GO:0005802; GO:0005886; GO:0006816; GO:0006828; GO:0006874; GO:0008544; GO:0016339; GO:0016887; GO:0030026; GO:0030036; GO:0030145; GO:0032468; GO:0032472; GO:0032580; GO:0033106; GO:0042998; GO:0043123; GO:0070588; GO:0098629; GO:0140613
GN001952	GN001952.1	Q96JJ7	31.3	83	100	454	7.69e-10	57.4	TMX3_HUMAN	Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3)	Homo sapiens (Human)		protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	GO:0003756; GO:0005783; GO:0005789; GO:0005886; GO:0009986; GO:0015035; GO:0031092
GN001954	GN001954.1	Q6GNG3	41.3	138	172	452	1.57e-23	99.0	TMX3_XENLA	Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3)	Xenopus laevis (African clawed frog)		protein disulfide isomerase activity [GO:0003756]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0003756; GO:0005783; GO:0005789; GO:0009986
GN001955	GN001955.1	Q7Z5L7	26.3	339	556	613	1.19e-09	64.7	PODN_HUMAN	Podocan	Homo sapiens (Human)	negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]	collagen binding [GO:0005518]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; gel phase of interstitial matrix [GO:0140150]	GO:0005518; GO:0005576; GO:0005737; GO:0008285; GO:0030336; GO:0031012; GO:0140150
GN001956	GN001956.1	Q9DGB6	27.4	343	401	781	2.84e-32	132	TLR22_CHICK	Toll-like receptor 2 type-2	Gallus gallus (Chicken)	detection of bacterial lipoprotein [GO:0042494]; immune response [GO:0006955]; inflammatory response [GO:0006954]; toll-like receptor signaling pathway [GO:0002224]	signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497]	plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0002224; GO:0004888; GO:0005886; GO:0006954; GO:0006955; GO:0038023; GO:0042494; GO:0042497; GO:0043235
GN001957	GN001957.1	Q9Y2C9	37.5	120	155	796	2.04e-14	72.8	TLR6_HUMAN	Toll-like receptor 6 (CD antigen CD286)	Homo sapiens (Human)	activation of NF-kappaB-inducing kinase activity [GO:0007250]; antibacterial innate immune response [GO:0140367]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide metabolic process [GO:0046209]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macrophage activation [GO:0043032]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	amyloid-beta binding [GO:0001540]; diacyl lipopeptide binding [GO:0042498]; identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	GO:0001540; GO:0001774; GO:0002224; GO:0002755; GO:0004888; GO:0005102; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0007165; GO:0007250; GO:0010628; GO:0030670; GO:0031663; GO:0032717; GO:0032720; GO:0032731; GO:0032755; GO:0034136; GO:0035355; GO:0035663; GO:0035666; GO:0038023; GO:0038124; GO:0042496; GO:0042498; GO:0042742; GO:0042802; GO:0043032; GO:0043123; GO:0043235; GO:0043507; GO:0045087; GO:0045121; GO:0045429; GO:0046209; GO:0046982; GO:0050729; GO:0071723; GO:0071726; GO:0140052; GO:0140367; GO:1900017; GO:1900227; GO:1903428; GO:1904646; GO:2001238
GN001958	GN001958.1	Q7Z7E8	32.1	162	359	422	1.00e-16	84.3	UB2Q1_HUMAN	Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Protein NICE-5) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1)	Homo sapiens (Human)	protein polyubiquitination [GO:0000209]	ubiquitin conjugating enzyme activity [GO:0061631]	cytosol [GO:0005829]; filopodium [GO:0030175]; nucleus [GO:0005634]	GO:0000209; GO:0005634; GO:0005829; GO:0030175; GO:0061631
GN001959	GN001959.1	Q8CHP0	43.2	266	770	950	2.90e-27	122	ZC3H3_MOUSE	Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor)	Mus musculus (Mouse)	mRNA 3'-end processing [GO:0031124]; positive regulation of activin receptor signaling pathway [GO:0032927]	metal ion binding [GO:0046872]; R-SMAD binding [GO:0070412]; SMAD binding [GO:0046332]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleus [GO:0005634]	GO:0005634; GO:0005847; GO:0031124; GO:0032927; GO:0046332; GO:0046872; GO:0070412
GN001960	GN001960.1	Q4U1U2	67.2	67	322	289	1.53e-15	79.0	MAFA_XENTR	Transcription factor MafA	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	insulin secretion [GO:0030073]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0009749; GO:0030073
GN001961	GN001961.1	Q0ZUL9	25.0	672	704	789	4.83e-33	139	TLR6_DASNO	Toll-like receptor 6 (CD antigen CD286)	Dasypus novemcinctus (Nine-banded armadillo)	cellular response to diacyl bacterial lipopeptide [GO:0071726]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; toll-like receptor signaling pathway [GO:0002224]	identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	GO:0002224; GO:0004888; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0030670; GO:0032731; GO:0035355; GO:0035663; GO:0042802; GO:0045121; GO:0071723; GO:0071726; GO:1900227
GN001962	GN001962.1	Q9DD78	24.6	569	576	793	9.61e-28	122	TLR21_CHICK	Toll-like receptor 2 type-1	Gallus gallus (Chicken)	immune response [GO:0006955]; inflammatory response [GO:0006954]; toll-like receptor signaling pathway [GO:0002224]	signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497]	plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0002224; GO:0004888; GO:0005886; GO:0006954; GO:0006955; GO:0038023; GO:0042497; GO:0043235
GN001963	GN001963.1	Q9JHA8	29.7	522	930	891	9.67e-44	175	VWA7_MOUSE	von Willebrand factor A domain-containing protein 7 (Protein G7c)	Mus musculus (Mouse)			extracellular region [GO:0005576]	GO:0005576
GN001965	GN001965.1	Q7QF91	32.2	267	356	405	2.68e-27	114	FUTC_ANOGA	Lewis-type alpha-(1,3)-fucosyltransferase (EC 2.4.1.152) (Fucosyltransferase C) (AgFucTC)	Anopheles gambiae (African malaria mosquito)	N-glycan processing [GO:0006491]	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0017083; GO:0032580; GO:0046920
GN001966	GN001966.1	A0A7M7H6R7	31.3	320	346	399	6.64e-38	142	FUTC_APIME	Lewis-type alpha-(1,3)-fucosyltransferase (EC 2.4.1.152) (Fucosyltransferase C) (AmFucTC)	Apis mellifera (Honeybee)	N-glycan processing [GO:0006491]	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0017083; GO:0032580
GN001967	GN001967.1	A0A1S4GHV7	28.3	297	308	493	1.05e-25	109	FUTA_ANOGA	Core alpha-(1,3)-fucosyltransferase (EC 2.4.1.214) (Fucosyltransferase A) (AgFucTA)	Anopheles gambiae (African malaria mosquito)	N-glycan processing [GO:0006491]	glycoprotein 3-alpha-L-fucosyltransferase activity [GO:0018392]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0018392; GO:0032580
GN001968	GN001968.1	A0A1S4GHV7	34.4	314	369	493	2.14e-43	160	FUTA_ANOGA	Core alpha-(1,3)-fucosyltransferase (EC 2.4.1.214) (Fucosyltransferase A) (AgFucTA)	Anopheles gambiae (African malaria mosquito)	N-glycan processing [GO:0006491]	glycoprotein 3-alpha-L-fucosyltransferase activity [GO:0018392]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0018392; GO:0032580
GN001969	GN001969.1	P41824	73.9	115	238	253	3.99e-42	146	YBOXH_APLCA	Y-box factor homolog (APY1)	Aplysia californica (California sea hare)		nucleic acid binding [GO:0003676]	nucleus [GO:0005634]	GO:0003676; GO:0005634
GN001974	GN001974.1	Q8VDP6	54.3	210	214	213	4.90e-78	236	CDIPT_MOUSE	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase)	Mus musculus (Mouse)	CDP-diacylglycerol metabolic process [GO:0046341]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipid biosynthetic process [GO:0008654]	alcohol binding [GO:0043178]; carbohydrate binding [GO:0030246]; CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity [GO:0003881]; diacylglycerol binding [GO:0019992]; manganese ion binding [GO:0030145]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0003881; GO:0005789; GO:0005886; GO:0006661; GO:0008654; GO:0016020; GO:0019992; GO:0030145; GO:0030246; GO:0043178; GO:0046341
GN001975	GN001975.1	Q9UJ41	48.0	102	171	491	1.53e-21	93.6	RABX5_HUMAN	Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5)	Homo sapiens (Human)	dendritic transport [GO:0098935]; endosomal transport [GO:0016197]; protein targeting to membrane [GO:0006612]	DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; presynaptic endosome [GO:0098830]; recycling endosome [GO:0055037]	GO:0003677; GO:0005085; GO:0005769; GO:0005829; GO:0006612; GO:0008270; GO:0016197; GO:0030139; GO:0030425; GO:0031267; GO:0031901; GO:0055037; GO:0061630; GO:0098830; GO:0098935
GN001976	GN001976.1	O18973	46.7	377	407	492	5.49e-106	324	RABX5_BOVIN	Rab5 GDP/GTP exchange factor (Rabex-5)	Bos taurus (Bovine)	vesicle-mediated transport [GO:0016192]	DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; recycling endosome [GO:0055037]	GO:0003677; GO:0005085; GO:0005737; GO:0005769; GO:0005829; GO:0008270; GO:0016192; GO:0030139; GO:0031267; GO:0055037
GN001980	GN001980.1	O61492	63.0	387	376	438	9.68e-149	430	FLOT2_DROME	Flotillin-2	Drosophila melanogaster (Fruit fly)	cell adhesion [GO:0007155]; melanotic encapsulation of foreign target [GO:0035011]; positive regulation of filopodium assembly [GO:0051491]; protein localization to plasma membrane [GO:0072659]; regulation of myoblast differentiation [GO:0045661]	protease binding [GO:0002020]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; plasma membrane [GO:0005886]	GO:0002020; GO:0005198; GO:0005737; GO:0005829; GO:0005886; GO:0007155; GO:0016600; GO:0031410; GO:0035011; GO:0045661; GO:0051491; GO:0072659
GN001981	GN001981.1	Q9JM76	75.3	158	177	178	1.59e-80	239	ARPC3_MOUSE	Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)	Mus musculus (Mouse)	Arp2/3 complex-mediated actin nucleation [GO:0034314]; regulation of synaptic vesicle endocytosis [GO:1900242]	actin filament binding [GO:0051015]; structural constituent of cytoskeleton [GO:0005200]	Arp2/3 protein complex [GO:0005885]; cell leading edge [GO:0031252]; filamentous actin [GO:0031941]; growth cone leading edge [GO:0061850]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0005200; GO:0005634; GO:0005885; GO:0030027; GO:0031252; GO:0031941; GO:0034314; GO:0035861; GO:0051015; GO:0061850; GO:1900242
GN001982	GN001982.1	Q9D3W4	69.6	263	282	284	3.03e-132	379	GPN3_MOUSE	GPN-loop GTPase 3 (EC 3.6.5.-) (ATP-binding domain 1 family member C)	Mus musculus (Mouse)	protein import into nucleus [GO:0006606]	GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0003924; GO:0005634; GO:0005737; GO:0006606; GO:0032991
GN001983	GN001983.1	Q1RMV0	50.8	648	620	640	3.58e-164	486	PEX5_BOVIN	Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)	Bos taurus (Bovine)	cellular response to reactive oxygen species [GO:0034614]; negative regulation of protein-containing complex assembly [GO:0031333]; pexophagy [GO:0000425]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; protein tetramerization [GO:0051262]	peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome membrane targeting sequence binding [GO:0033328]; protein carrier activity [GO:0140597]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	GO:0000425; GO:0005052; GO:0005777; GO:0005778; GO:0005782; GO:0005794; GO:0005829; GO:0006625; GO:0016558; GO:0016560; GO:0016561; GO:0016562; GO:0030674; GO:0031267; GO:0031333; GO:0032991; GO:0033328; GO:0034614; GO:0044721; GO:0045046; GO:0051262; GO:0140597
GN001985	GN001985.1	A0NLY7	27.9	201	234	263	2.63e-20	89.7	ISAHY_ROSAI	Isatin hydrolase (EC 3.5.2.20) (Isatin amidohydrolase) (Isatin hydrolase isoform b) (IH-b)	Roseibium aggregatum (strain ATCC 25650 / DSM 13394 / JCM 20685 / NBRC 16684 / NCIMB 2208 / IAM 12614 / B1) (Stappia aggregata)		arylformamidase activity [GO:0004061]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; manganese ion binding [GO:0030145]		GO:0004061; GO:0016812; GO:0030145
GN001986	GN001986.1	A0NLY7	27.5	211	336	263	1.22e-18	87.4	ISAHY_ROSAI	Isatin hydrolase (EC 3.5.2.20) (Isatin amidohydrolase) (Isatin hydrolase isoform b) (IH-b)	Roseibium aggregatum (strain ATCC 25650 / DSM 13394 / JCM 20685 / NBRC 16684 / NCIMB 2208 / IAM 12614 / B1) (Stappia aggregata)		arylformamidase activity [GO:0004061]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; manganese ion binding [GO:0030145]		GO:0004061; GO:0016812; GO:0030145
GN001992	GN001992.1	F1NZI4	36.9	677	797	702	1.38e-143	442	PGGHG_CHICK	Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107) (Acid trehalase-like protein 1)	Gallus gallus (Chicken)	carbohydrate metabolic process [GO:0005975]	protein-glucosylgalactosylhydroxylysine glucosidase activity [GO:0047402]	cytosol [GO:0005829]	GO:0005829; GO:0005975; GO:0047402
GN001994	GN001994.1	Q9QYS2	30.9	828	903	879	2.04e-105	350	GRM3_MOUSE	Metabotropic glutamate receptor 3 (mGluR3)	Mus musculus (Mouse)	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to stress [GO:0033554]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; modulation of chemical synaptic transmission [GO:0050804]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]; synaptic transmission, glutamatergic [GO:0035249]	calcium channel regulator activity [GO:0005246]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110]	astrocyte projection [GO:0097449]; axon [GO:0030424]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]	GO:0001641; GO:0005246; GO:0005886; GO:0007193; GO:0007216; GO:0010467; GO:0014069; GO:0019233; GO:0030424; GO:0033554; GO:0035249; GO:0042734; GO:0043005; GO:0043197; GO:0045211; GO:0048786; GO:0050804; GO:0051930; GO:0051966; GO:0097110; GO:0097449; GO:0098978; GO:0099170
GN001995	GN001995.1	O00222	31.3	850	1028	908	3.65e-112	372	GRM8_HUMAN	Metabotropic glutamate receptor 8 (mGluR8)	Homo sapiens (Human)	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; regulation of synaptic transmission, glutamatergic [GO:0051966]; visual perception [GO:0007601]	G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]	plasma membrane [GO:0005886]	GO:0001642; GO:0004930; GO:0005886; GO:0007193; GO:0007196; GO:0007216; GO:0007601; GO:0008066; GO:0051966
GN001999	GN001999.1	P35408	29.4	323	332	488	4.28e-32	128	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of stress fiber assembly [GO:0051492]; response to mechanical stimulus [GO:0009612]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0009612; GO:0016020; GO:0033624; GO:0034695; GO:0042093; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070371; GO:0071260; GO:0071380; GO:2000420
GN002001	GN002001.1	P35408	26.6	323	336	488	9.72e-26	110	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of stress fiber assembly [GO:0051492]; response to mechanical stimulus [GO:0009612]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0009612; GO:0016020; GO:0033624; GO:0034695; GO:0042093; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070371; GO:0071260; GO:0071380; GO:2000420
GN002002	GN002002.1	P21731	30.6	196	262	343	9.16e-15	76.3	TA2R_HUMAN	Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to lipopolysaccharide [GO:0071222]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of vasoconstriction [GO:0045907]; response to ethanol [GO:0045471]; response to nutrient [GO:0007584]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]	guanyl-nucleotide exchange factor activity [GO:0005085]; thromboxane A2 receptor activity [GO:0004961]	acrosomal vesicle [GO:0001669]; plasma membrane [GO:0005886]	GO:0001669; GO:0004961; GO:0005085; GO:0005886; GO:0006954; GO:0007186; GO:0007189; GO:0007204; GO:0007584; GO:0009410; GO:0030194; GO:0033574; GO:0045471; GO:0045766; GO:0045777; GO:0045907; GO:0071222; GO:0090051
GN002003	GN002003.1	P35408	38.4	99	241	488	2.10e-13	72.4	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of stress fiber assembly [GO:0051492]; response to mechanical stimulus [GO:0009612]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0009612; GO:0016020; GO:0033624; GO:0034695; GO:0042093; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070371; GO:0071260; GO:0071380; GO:2000420
GN002004	GN002004.1	P21731	25.9	294	323	343	1.59e-18	88.2	TA2R_HUMAN	Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to lipopolysaccharide [GO:0071222]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of vasoconstriction [GO:0045907]; response to ethanol [GO:0045471]; response to nutrient [GO:0007584]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]	guanyl-nucleotide exchange factor activity [GO:0005085]; thromboxane A2 receptor activity [GO:0004961]	acrosomal vesicle [GO:0001669]; plasma membrane [GO:0005886]	GO:0001669; GO:0004961; GO:0005085; GO:0005886; GO:0006954; GO:0007186; GO:0007189; GO:0007204; GO:0007584; GO:0009410; GO:0030194; GO:0033574; GO:0045471; GO:0045766; GO:0045777; GO:0045907; GO:0071222; GO:0090051
GN002007	GN002007.1	A3DH97	35.6	365	1296	760	8.74e-60	224	RSGI6_ACET2	Anti-sigma-I factor RsgI6 (Endo-1,4-beta-xylanase) (EC 3.2.1.8)	Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)	xylan catabolic process [GO:0045493]	endo-1,4-beta-xylanase activity [GO:0031176]	plasma membrane [GO:0005886]	GO:0005886; GO:0031176; GO:0045493
GN002008	GN002008.1	P97814	32.5	286	353	415	1.05e-36	140	PPIP1_MOUSE	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1)	Mus musculus (Mouse)		actin binding [GO:0003779]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]	actomyosin contractile ring [GO:0005826]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; uropod [GO:0001931]	GO:0001725; GO:0001931; GO:0003779; GO:0005737; GO:0005826; GO:0005829; GO:0005886; GO:0019903; GO:0030027; GO:0032154; GO:0042802; GO:0048471
GN002010	GN002010.1	Q5M7K0	51.9	181	196	186	3.96e-54	173	TIM22_XENTR	Mitochondrial import inner membrane translocase subunit Tim22	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	protein insertion into mitochondrial inner membrane [GO:0045039]		mitochondrial inner membrane [GO:0005743]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]	GO:0005743; GO:0042721; GO:0045039
GN002011	GN002011.1	P13944	34.9	186	1132	3124	1.17e-21	106	COCA1_CHICK	Collagen alpha-1(XII) chain (Fibrochimerin)	Gallus gallus (Chicken)	endodermal cell differentiation [GO:0035987]		interstitial matrix [GO:0005614]	GO:0005614; GO:0035987
GN002012	GN002012.1	P05099	25.8	423	670	493	1.03e-36	147	MATN1_CHICK	Matrilin-1 (Cartilage matrix protein)	Gallus gallus (Chicken)		calcium ion binding [GO:0005509]	extracellular matrix [GO:0031012]	GO:0005509; GO:0031012
GN002013	GN002013.1	O43301	30.3	495	617	675	3.01e-47	179	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN002015	GN002015.1	Q96MM6	29.3	502	725	686	2.55e-50	190	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN002016	GN002016.1	Q8K0U4	28.7	390	359	675	2.39e-37	145	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN002019	GN002019.1	Q5BIR5	45.8	373	379	374	9.81e-98	298	SPB8_BOVIN	Serpin B8	Bos taurus (Bovine)		serine-type endopeptidase inhibitor activity [GO:0004867]	cytoplasm [GO:0005737]	GO:0004867; GO:0005737
GN002020	GN002020.1	Q6ZFT5	54.2	284	337	325	9.86e-109	323	KPRS4_ORYSJ	Ribose-phosphate pyrophosphokinase 4 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 4)	Oryza sativa subsp. japonica (Rice)	5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; purine nucleotide biosynthetic process [GO:0006164]	magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749]	cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189]	GO:0000287; GO:0002189; GO:0004749; GO:0005737; GO:0006015; GO:0006164
GN002021	GN002021.1	Q6DDI6	52.6	957	942	1089	9.48e-319	910	TBC31_XENLA	TBC1 domain family member 31	Xenopus laevis (African clawed frog)	cilium assembly [GO:0060271]	molecular adaptor activity [GO:0060090]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]	GO:0005813; GO:0034451; GO:0036064; GO:0060090; GO:0060271
GN002022	GN002022.1	Q9BUN8	60.1	248	253	251	3.53e-111	323	DERL1_HUMAN	Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)	Homo sapiens (Human)	cellular response to misfolded protein [GO:0071218]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511]	ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; MHC class I protein binding [GO:0042288]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; signal recognition particle binding [GO:0005047]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-specific protease binding [GO:1990381]	ATPase complex [GO:1904949]; cytoplasm [GO:0005737]; Derlin-1 retrotranslocation complex [GO:0036513]; Derlin-1-VIMP complex [GO:0036502]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; late endosome [GO:0005770]; membrane [GO:0016020]	GO:0002020; GO:0005047; GO:0005737; GO:0005769; GO:0005770; GO:0005783; GO:0005789; GO:0006511; GO:0006986; GO:0016020; GO:0030968; GO:0030970; GO:0031398; GO:0031625; GO:0031648; GO:0036502; GO:0036503; GO:0036513; GO:0038023; GO:0042288; GO:0042802; GO:0043161; GO:0044322; GO:0044877; GO:0045184; GO:0051117; GO:0071218; GO:1904949; GO:1990381
GN002023	GN002023.1	P83310	24.2	302	266	295	3.32e-12	68.6	RDPA_DELAC	(R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase (RdpA) (EC 1.14.11.44) ((R)-dichlorprop/(R)-mecoprop dioxygenase) (Alpha-ketoglutarate-dependent dioxygenase) (Dichlorprop/alpha-ketoglutarate-dioxygenase) (Mecoprop/alpha-ketoglutarate-dioxygenase)	Delftia acidovorans (Pseudomonas acidovorans) (Comamonas acidovorans)		2-oxoglutarate-dependent dioxygenase activity [GO:0016706]	cytoplasm [GO:0005737]	GO:0005737; GO:0016706
GN002024	GN002024.1	Q3U435	41.7	444	597	615	1.03e-100	321	MMP25_MOUSE	Matrix metalloproteinase-25 (MMP-25) (EC 3.4.24.-)	Mus musculus (Mouse)	collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; hard palate development [GO:0060022]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; peptidase activator activity [GO:0016504]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; plasma membrane [GO:0005886]	GO:0004222; GO:0005886; GO:0006508; GO:0008270; GO:0009986; GO:0016504; GO:0030198; GO:0030574; GO:0031012; GO:0060022
GN002029	GN002029.1	Q9CWK3	37.4	358	381	342	6.47e-56	189	CD2B2_MOUSE	CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2)	Mus musculus (Mouse)		ribonucleoprotein complex binding [GO:0043021]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U5 snRNP [GO:0005682]	GO:0001650; GO:0005634; GO:0005654; GO:0005681; GO:0005682; GO:0005829; GO:0016607; GO:0043021
GN002031	GN002031.1	Q08AX9	49.0	296	275	715	1.85e-67	225	SANBR_XENLA	SANT and BTB domain regulator of class switch recombination (SANT and BTB domain regulator of CSR)	Xenopus laevis (African clawed frog)	isotype switching [GO:0045190]	identical protein binding [GO:0042802]		GO:0042802; GO:0045190
GN002032	GN002032.1	P18293	44.6	720	1067	1057	2.15e-185	570	ANPRA_MOUSE	Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)	Mus musculus (Mouse)	cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	ANPR-A receptor complex [GO:1990620]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005789; GO:0005886; GO:0006182; GO:0007166; GO:0007168; GO:0008217; GO:0016020; GO:0016941; GO:0017046; GO:0031965; GO:0035556; GO:0042417; GO:0042562; GO:0043114; GO:0043235; GO:0048662; GO:1990620
GN002035	GN002035.1	A4QNN3	35.7	445	644	519	2.30e-79	264	UBP30_XENTR	Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mitochondrial fusion [GO:0008053]; negative regulation of mitophagy [GO:1901525]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K6-linked deubiquitination [GO:0044313]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0004197; GO:0004843; GO:0005739; GO:0005741; GO:0008053; GO:0016579; GO:0035871; GO:0044313; GO:1901525
GN002036	GN002036.1	O54992	46.0	315	555	473	5.24e-81	264	MAPK5_MOUSE	MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAPK-5) (EC 2.7.11.1)	Mus musculus (Mouse)	negative regulation of TOR signaling [GO:0032007]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; Ras protein signal transduction [GO:0007265]; regulation of translation [GO:0006417]; stress-induced premature senescence [GO:0090400]	ATP binding [GO:0005524]; mitogen-activated protein kinase binding [GO:0051019]; p53 binding [GO:0002039]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; septin cytoskeleton [GO:0032156]	GO:0002039; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006417; GO:0007265; GO:0032007; GO:0032156; GO:0032206; GO:0032991; GO:0045944; GO:0046777; GO:0051019; GO:0060999; GO:0090400; GO:0106310
GN002037	GN002037.1	Q96S79	52.5	198	209	203	4.62e-70	215	RSLAB_HUMAN	Ras-like protein family member 10B (EC 3.6.5.2) (Ras-like protein VTS58635) (Ras-related protein 17) (RRP17)	Homo sapiens (Human)	positive regulation of peptide hormone secretion [GO:0090277]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]	GO:0003050; GO:0003924; GO:0003925; GO:0005525; GO:0005886; GO:0090277
GN002038	GN002038.1	Q28D99	54.9	474	557	511	4.35e-195	558	GADL1_XENTR	Acidic amino acid decarboxylase GADL1 (Aspartate 1-decarboxylase) (ADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (EC 4.1.1.29) (Glutamate decarboxylase-like protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		aspartate 1-decarboxylase activity [GO:0004068]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170]; sulfinoalanine decarboxylase activity [GO:0004782]	cytoplasm [GO:0005737]	GO:0004068; GO:0004782; GO:0005737; GO:0016831; GO:0030170
GN002039	GN002039.1	P61406	44.7	998	1708	1418	9.66e-217	682	EST1A_MOUSE	Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog)	Mus musculus (Mouse)	negative regulation of telomere capping [GO:1904354]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of telomere maintenance [GO:0032204]	DNA polymerase binding [GO:0070182]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; telomerase RNA binding [GO:0070034]; telomeric repeat DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; telomerase holoenzyme complex [GO:0005697]	GO:0000184; GO:0000781; GO:0003723; GO:0004521; GO:0005634; GO:0005697; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0032204; GO:0035145; GO:0036064; GO:0042162; GO:0043021; GO:0070034; GO:0070182; GO:1904354
GN002042	GN002042.1	A9XE49	30.2	159	191	200	6.86e-11	62.0	IL17L_MAGGI	Interleukin 17-like protein (CgIL-17)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		cytokine activity [GO:0005125]	extracellular region [GO:0005576]	GO:0005125; GO:0005576
GN002045	GN002045.1	P47727	54.9	268	279	277	5.17e-102	301	CBR1_RAT	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)	Rattus norvegicus (Rat)	epithelial cell differentiation [GO:0030855]; glucocorticoid metabolic process [GO:0008211]; ovulation from ovarian follicle [GO:0001542]; phylloquinone catabolic process [GO:0042376]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; prostaglandin catabolic process [GO:1905344]; response to estradiol [GO:0032355]; response to gonadotropin [GO:0034698]; response to lipopolysaccharide [GO:0032496]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; steroid catabolic process [GO:0006706]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH dehydrogenase (quinone) activity [GO:0008753]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E2 9-reductase activity [GO:0050221]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microvillus [GO:0005902]	GO:0001542; GO:0004090; GO:0005737; GO:0005829; GO:0005902; GO:0006706; GO:0006805; GO:0008106; GO:0008211; GO:0008753; GO:0016616; GO:0016655; GO:0030855; GO:0032355; GO:0032496; GO:0032570; GO:0033574; GO:0034698; GO:0042373; GO:0042376; GO:0047020; GO:0047021; GO:0050221; GO:0160163; GO:1905344; GO:2000379
GN002047	GN002047.1	Q5ZKM1	70.6	235	238	832	3.56e-112	343	SPB1_CHICK	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3)	Gallus gallus (Chicken)	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; RNA methylation [GO:0001510]; rRNA methylation [GO:0031167]	RNA 2'-O-methyltransferase activity [GO:0062105]; rRNA (guanine) methyltransferase activity [GO:0016435]; rRNA (uridine-2'-O-ribose)-methyltransferase activity [GO:0008650]	nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]; preribosome, small subunit precursor [GO:0030688]	GO:0000463; GO:0000466; GO:0001510; GO:0005730; GO:0008650; GO:0016435; GO:0030687; GO:0030688; GO:0031167; GO:0062105
GN002048	GN002048.1	Q5ZKM1	38.4	333	409	832	1.80e-57	204	SPB1_CHICK	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3)	Gallus gallus (Chicken)	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; RNA methylation [GO:0001510]; rRNA methylation [GO:0031167]	RNA 2'-O-methyltransferase activity [GO:0062105]; rRNA (guanine) methyltransferase activity [GO:0016435]; rRNA (uridine-2'-O-ribose)-methyltransferase activity [GO:0008650]	nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]; preribosome, small subunit precursor [GO:0030688]	GO:0000463; GO:0000466; GO:0001510; GO:0005730; GO:0008650; GO:0016435; GO:0030687; GO:0030688; GO:0031167; GO:0062105
GN002049	GN002049.1	Q8GWA1	41.8	110	95	510	1.02e-18	82.4	NDA1_ARATH	Internal alternative NAD(P)H-ubiquinone oxidoreductase A1, mitochondrial (EC 1.6.5.9) (Internal alternative NADH dehydrogenase NDA1) (Internal non-phosphorylating NAD(P)H dehydrogenase 1) (AtNDI1) (NADH:ubiquinone reductase (non-electrogenic) NDA1)	Arabidopsis thaliana (Mouse-ear cress)	cellular response to light stimulus [GO:0071482]	NADH dehydrogenase (ubiquinone) (non-electrogenic) activity [GO:0120555]; NADH dehydrogenase activity [GO:0003954]; NADPH dehydrogenase activity [GO:0003959]; oxidoreductase activity [GO:0016491]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]	GO:0003954; GO:0003959; GO:0005739; GO:0005743; GO:0005759; GO:0005777; GO:0016491; GO:0071482; GO:0120555
GN002050	GN002050.1	Q0P4H0	61.8	165	174	170	5.93e-71	214	ADAT2_XENTR	tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2 (EC 3.5.4.33) (Deaminase domain-containing protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	tRNA wobble adenosine to inosine editing [GO:0002100]	tRNA-specific adenosine-34 deaminase activity [GO:0052717]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0002100; GO:0005634; GO:0005737; GO:0008270; GO:0052717
GN002051	GN002051.1	Q174D3	60.2	171	219	253	5.47e-60	191	MED19_AEDAE	Mediator of RNA polymerase II transcription subunit 19 (Mediator complex subunit 19)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	positive regulation of transcription by RNA polymerase II [GO:0045944]	transcription coregulator activity [GO:0003712]	mediator complex [GO:0016592]	GO:0003712; GO:0016592; GO:0045944
GN002052	GN002052.1	Q92887	45.8	144	189	1545	3.26e-33	128	MRP2_HUMAN	ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2)	Homo sapiens (Human)	bile acid and bile salt transport [GO:0015721]; bilirubin transport [GO:0015723]; heme catabolic process [GO:0042167]; leukotriene transport [GO:0071716]; negative regulation of gene expression [GO:0010629]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic export from cell [GO:0046618]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport across blood-brain barrier [GO:1990962]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; bilirubin transmembrane transporter activity [GO:0015127]; toxin transmembrane transporter activity [GO:0019534]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; intercellular canaliculus [GO:0046581]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GO:0005524; GO:0005886; GO:0006805; GO:0006855; GO:0008559; GO:0009986; GO:0010629; GO:0015127; GO:0015431; GO:0015721; GO:0015723; GO:0016324; GO:0016887; GO:0019534; GO:0022857; GO:0031982; GO:0042167; GO:0042626; GO:0042910; GO:0046581; GO:0046618; GO:0055085; GO:0070633; GO:0071716; GO:0140359; GO:0150104; GO:1990962
GN002053	GN002053.1	O93530	32.7	248	334	1436	6.44e-21	97.4	WRN_XENLA	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Focus-forming activity 1) (FFA-1) (Werner syndrome protein homolog) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Xenopus laevis (African clawed frog)	DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; four-way junction helicase activity [GO:0009378]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000723; GO:0000724; GO:0000781; GO:0003676; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006259; GO:0006260; GO:0008408; GO:0009378; GO:0016887; GO:0030145; GO:0032392; GO:0043138
GN002056	GN002056.1	B2RX12	42.2	853	896	1523	2.87e-179	561	MRP3_MOUSE	ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multidrug resistance-associated protein 3)	Mus musculus (Mouse)	bile acid and bile salt transport [GO:0015721]; canalicular bile acid transport [GO:0015722]; leukotriene transport [GO:0071716]; monoatomic anion transmembrane transport [GO:0098656]; transmembrane transport [GO:0055085]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; glucuronoside transmembrane transporter activity [GO:0015164]; icosanoid transmembrane transporter activity [GO:0071714]; xenobiotic transmembrane transporter activity [GO:0042910]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; ciliary basal body [GO:0036064]; plasma membrane [GO:0005886]	GO:0005524; GO:0005886; GO:0006855; GO:0008559; GO:0009925; GO:0015164; GO:0015431; GO:0015432; GO:0015721; GO:0015722; GO:0016323; GO:0016887; GO:0036064; GO:0042626; GO:0042908; GO:0042910; GO:0055085; GO:0071714; GO:0071716; GO:0098656
GN002057	GN002057.1	Q8IS64	57.1	680	805	727	2.13e-276	783	ECE_LOCMI	Endothelin-converting enzyme homolog (ECE) (EC 3.4.24.-)	Locusta migratoria (Migratory locust)	protein processing [GO:0016485]	endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]	GO:0004175; GO:0004222; GO:0005886; GO:0008270; GO:0016485
GN002059	GN002059.1	Q8JFP1	84.6	52	75	407	4.57e-24	95.9	IF4A2_CHICK	Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)	Gallus gallus (Chicken)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]		GO:0003676; GO:0003724; GO:0005524; GO:0016887
GN002065	GN002065.1	Q29HG0	54.9	253	284	289	2.01e-88	268	PGAM5_DROPS	Serine/threonine-protein phosphatase Pgam5, mitochondrial (EC 3.1.3.16) (Phosphoglycerate mutase family member 5 homolog)	Drosophila pseudoobscura pseudoobscura (Fruit fly)	positive regulation of mitochondrial fission [GO:0090141]	protein serine/threonine phosphatase activity [GO:0004722]	mitochondrial outer membrane [GO:0005741]	GO:0004722; GO:0005741; GO:0090141
GN002066	GN002066.1	Q5ZKG1	36.2	138	201	143	1.42e-14	70.9	RM51_CHICK	Large ribosomal subunit protein mL51 (39S ribosomal protein L51, mitochondrial) (L51mt) (MRP-L51)	Gallus gallus (Chicken)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005762; GO:0006412
GN002068	GN002068.1	Q9Y345	47.2	409	442	797	1.78e-118	367	SC6A5_HUMAN	Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5)	Homo sapiens (Human)	chemical synaptic transmission [GO:0007268]; glycine import across plasma membrane [GO:1903804]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725]; synaptic transmission, glycinergic [GO:0060012]	glycine:sodium symporter activity [GO:0015375]	dense core granule [GO:0031045]; endosome [GO:0005768]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0005768; GO:0005886; GO:0006836; GO:0007268; GO:0015375; GO:0016020; GO:0031045; GO:0035725; GO:0045202; GO:0060012; GO:1903804
GN002069	GN002069.1	Q2YDN1	26.3	316	468	528	4.90e-21	99.4	GP161_BOVIN	G protein-coupled receptor 161	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; limb development [GO:0060173]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; regulation of neuron migration [GO:2001222]; skeletal system development [GO:0001501]	G protein-coupled receptor activity [GO:0004930]; signaling adaptor activity [GO:0035591]	non-motile cilium membrane [GO:0098804]; recycling endosome [GO:0055037]	GO:0001501; GO:0004930; GO:0007189; GO:0021549; GO:0030900; GO:0035591; GO:0055037; GO:0060173; GO:0098804; GO:1901621; GO:2001222
GN002072	GN002072.1	A8JF70	29.4	235	249	552	4.31e-19	89.4	ODA1_CHLRE	Outer dynein arm protein 1 (Docking complex component 2)	Chlamydomonas reinhardtii (Chlamydomonas smithii)	cilium movement involved in cell motility [GO:0060294]; outer dynein arm assembly [GO:0036158]		outer dynein arm [GO:0036157]	GO:0036157; GO:0036158; GO:0060294
GN002074	GN002074.1	Q8WYQ5	46.8	265	309	773	1.94e-64	219	DGCR8_HUMAN	Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)	Homo sapiens (Human)	DNA damage response [GO:0006974]; positive regulation of pre-miRNA processing [GO:2000633]; primary miRNA processing [GO:0031053]	double-stranded RNA binding [GO:0003725]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; protein-RNA adaptor activity [GO:0140517]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; microprocessor complex [GO:0070877]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; site of double-strand break [GO:0035861]	GO:0003725; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006974; GO:0014069; GO:0016604; GO:0020037; GO:0030674; GO:0031053; GO:0035861; GO:0042802; GO:0042803; GO:0070877; GO:0070878; GO:0098978; GO:0140517; GO:2000633
GN002075	GN002075.1	Q9BZ19	37.7	162	475	345	7.61e-29	119	ANR60_HUMAN	Ankyrin repeat domain-containing protein 60	Homo sapiens (Human)				
GN002076	GN002076.1	Q0MQI8	67.0	233	247	249	7.10e-109	317	NDUV2_GORGO	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 7.1.1.2) (NADH-ubiquinone oxidoreductase 24 kDa subunit)	Gorilla gorilla gorilla (Western lowland gorilla)	mitochondrial electron transport, NADH to ubiquinone [GO:0006120]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; respiratory chain complex I [GO:0045271]	GO:0005743; GO:0006120; GO:0008137; GO:0045271
GN002077	GN002077.1	Q149F1	42.5	440	607	553	5.92e-103	325	RUSD2_MOUSE	Pseudouridylate synthase RPUSD2 (EC 5.4.99.-) (EC 5.4.99.28) (EC 5.4.99.42) (RNA pseudouridylate synthase domain-containing protein 2)	Mus musculus (Mouse)	enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA pseudouridine synthesis [GO:1990481]; tRNA pseudouridine synthesis [GO:0031119]	pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029]; tRNA pseudouridine(31) synthase activity [GO:0160152]; tRNA pseudouridine(32) synthase activity [GO:0160151]		GO:0000455; GO:0003723; GO:0009982; GO:0031119; GO:0106029; GO:0160151; GO:0160152; GO:1990481
GN002078	GN002078.1	P22735	38.0	716	854	817	2.80e-135	426	TGM1_HUMAN	Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) [Cleaved into: Protein-glutamine gamma-glutamyltransferase K 67 kDa chain; Protein-glutamine gamma-glutamyltransferase K 33 kDa chain]	Homo sapiens (Human)	cell envelope organization [GO:0043163]; cornification [GO:0070268]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838]; protein modification process [GO:0036211]	identical protein binding [GO:0042802]; protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	cornified envelope [GO:0001533]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001533; GO:0003810; GO:0005829; GO:0005886; GO:0010838; GO:0016020; GO:0018149; GO:0030216; GO:0036211; GO:0042802; GO:0043163; GO:0045787; GO:0070062; GO:0070268
GN002079	GN002079.1	P52183	36.0	297	386	772	1.66e-54	195	ANNU_SCHAM	Annulin (Protein-glutamine gamma-glutamyltransferase) (EC 2.3.2.13) (Transglutaminase)	Schistocerca americana (American grasshopper)		protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	plasma membrane [GO:0005886]	GO:0003810; GO:0005886
GN002080	GN002080.1	P22758	32.1	252	218	836	7.91e-31	122	TGM1_RABIT	Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) [Cleaved into: Protein-glutamine gamma-glutamyltransferase K 67 kDa chain; Protein-glutamine gamma-glutamyltransferase K 33 kDa chain]	Oryctolagus cuniculus (Rabbit)	animal organ development [GO:0048513]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838]	protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0003810; GO:0005829; GO:0005886; GO:0010838; GO:0045787; GO:0048513
GN002083	GN002083.1	G3X987	29.6	199	646	291	7.99e-11	67.0	GIMA9_MOUSE	GTPase IMAP family member 9 (Immune-associated nucleotide-binding protein 7) (IAN-7) (Immunity-associated nucleotide-binding protein 7)	Mus musculus (Mouse)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]		GO:0003924; GO:0005525
GN002089	GN002089.1	Q99MN1	68.9	578	578	595	6.91e-293	810	SYK_MOUSE	Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)	Mus musculus (Mouse)	basophil activation involved in immune response [GO:0002276]; diadenosine tetraphosphate biosynthetic process [GO:0015966]; ERK1 and ERK2 cascade [GO:0070371]; lysyl-tRNA aminoacylation [GO:0006430]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of inflammatory response to antigenic stimulus [GO:0002863]; positive regulation of macrophage activation [GO:0043032]; response to X-ray [GO:0010165]	amino acid binding [GO:0016597]; ATP binding [GO:0005524]; ATP:ADP adenylyltransferase activity [GO:0003877]; identical protein binding [GO:0042802]; lysine-tRNA ligase activity [GO:0004824]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]; tRNA binding [GO:0000049]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000049; GO:0002276; GO:0002863; GO:0003877; GO:0004824; GO:0005524; GO:0005576; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006430; GO:0010165; GO:0015966; GO:0016597; GO:0017101; GO:0042802; GO:0042803; GO:0043032; GO:0045893; GO:0070371; GO:0097110
GN002093	GN002093.1	O65431	28.9	142	290	504	1.92e-09	61.6	GALS3_ARATH	Galactan beta-1,4-galactosyltransferase GALS3 (EC 2.4.1.-) (Beta-1,4-galactan synthase) (Galactan synthase 3)	Arabidopsis thaliana (Mouse-ear cress)	cell wall biogenesis [GO:0042546]		Golgi membrane [GO:0000139]	GO:0000139; GO:0042546
GN002094	GN002094.1	Q90871	31.3	393	466	425	2.04e-41	155	IRF8_CHICK	Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (ICSBP)	Gallus gallus (Chicken)	cellular response to type II interferon [GO:0071346]; dendritic cell differentiation [GO:0097028]; immune response [GO:0006955]; immune system process [GO:0002376]; negative regulation of transcription by RNA polymerase II [GO:0000122]; plasmacytoid dendritic cell differentiation [GO:0002273]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type I interferon production [GO:0032479]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0001227; GO:0002273; GO:0002376; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0006955; GO:0032479; GO:0045944; GO:0071346; GO:0097028
GN002095	GN002095.1	Q9GKT2	49.8	217	2145	333	3.81e-64	225	FXDC2_MACFA	Fatty acid hydroxylase domain-containing protein 2	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	lipid biosynthetic process [GO:0008610]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of protein phosphorylation [GO:0001934]	iron ion binding [GO:0005506]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0001934; GO:0005506; GO:0005737; GO:0008610; GO:0016020; GO:0045654
GN002099	GN002099.1	P54131	39.6	270	394	499	2.79e-52	184	ACHA7_BOVIN	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Bos taurus (Bovine)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN002100	GN002100.1	P27485	26.6	184	215	201	2.72e-09	58.2	RET4_PIG	Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP)	Sus scrofa (Pig)	retinol transport [GO:0034633]	retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632]	extracellular region [GO:0005576]	GO:0005576; GO:0019841; GO:0034632; GO:0034633
GN002101	GN002101.1	Q8R0A7	36.6	410	591	407	8.28e-64	218	K0513_MOUSE	Uncharacterized protein KIAA0513	Mus musculus (Mouse)				
GN002102	GN002102.1	Q32PH2	30.7	306	374	457	6.26e-22	100	TM143_BOVIN	Transmembrane protein 143	Bos taurus (Bovine)			membrane [GO:0016020]; mitochondrion [GO:0005739]	GO:0005739; GO:0016020
GN002103	GN002103.1	Q9Y248	66.0	144	156	185	1.51e-67	206	PSF2_HUMAN	DNA replication complex GINS protein PSF2 (GINS complex subunit 2)	Homo sapiens (Human)	DNA replication [GO:0006260]; double-strand break repair via break-induced replication [GO:0000727]		CMG complex [GO:0071162]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000727; GO:0000811; GO:0005634; GO:0005654; GO:0006260; GO:0071162
GN002106	GN002106.1	Q23157	24.9	353	429	465	9.30e-25	109	INX11_CAEEL	Innexin-11 (Protein opu-11)	Caenorhabditis elegans		gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005921; GO:0055077
GN002108	GN002108.1	Q5UPX0	34.3	251	369	548	3.85e-30	124	YR290_MIMIV	Putative ATP-dependent RNA helicase R290 (EC 3.6.4.13)	Acanthamoeba polyphaga mimivirus (APMV)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]		GO:0003676; GO:0003724; GO:0005524; GO:0006260; GO:0006281; GO:0006310; GO:0016887; GO:0043138
GN002112	GN002112.1	Q03567	30.8	396	427	493	3.23e-47	172	SL172_CAEEL	Uncharacterized transporter slc-17.2	Caenorhabditis elegans		transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0016020; GO:0022857
GN002128	GN002128.1	Q9GKX6	38.5	343	350	342	7.19e-79	248	GALM_PIG	Galactose mutarotase (EC 5.1.3.3) (Aldose 1-epimerase)	Sus scrofa (Pig)	galactose catabolic process via UDP-galactose, Leloir pathway [GO:0033499]; glucose metabolic process [GO:0006006]	aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246]	cytoplasm [GO:0005737]	GO:0004034; GO:0005737; GO:0006006; GO:0030246; GO:0033499
GN002133	GN002133.1	A0A7M7H6R7	30.6	314	338	399	2.06e-32	127	FUTC_APIME	Lewis-type alpha-(1,3)-fucosyltransferase (EC 2.4.1.152) (Fucosyltransferase C) (AmFucTC)	Apis mellifera (Honeybee)	N-glycan processing [GO:0006491]	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0017083; GO:0032580
GN002135	GN002135.1	Q8AV58	33.6	119	465	2169	3.67e-09	63.2	SDK1_CHICK	Protein sidekick-1	Gallus gallus (Chicken)	homophilic cell-cell adhesion [GO:0007156]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416]	identical protein binding [GO:0042802]	plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0005886; GO:0007156; GO:0007416; GO:0010842; GO:0042802; GO:0045202
GN002139	GN002139.1	A0A7M7H6R7	30.9	272	250	399	1.15e-29	117	FUTC_APIME	Lewis-type alpha-(1,3)-fucosyltransferase (EC 2.4.1.152) (Fucosyltransferase C) (AmFucTC)	Apis mellifera (Honeybee)	N-glycan processing [GO:0006491]	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0017083; GO:0032580
GN002141	GN002141.1	Q8TBY9	46.1	898	1119	1149	3.50e-293	853	CF251_HUMAN	Cilia- and flagella-associated protein 251 (WD repeat-containing protein 66)	Homo sapiens (Human)	cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]		axoneme [GO:0005930]; motile cilium [GO:0031514]; sperm end piece [GO:0097229]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]	GO:0003341; GO:0005930; GO:0030317; GO:0031514; GO:0036126; GO:0097225; GO:0097229
GN002142	GN002142.1	Q6NRQ2	59.5	227	235	526	2.70e-88	273	NOC4A_XENLA	Nucleolar complex protein 4 homolog A (NOC4 protein homolog A) (NOC4-like protein A) (Nucleolar complex-associated protein 4-like protein A)	Xenopus laevis (African clawed frog)	ribosome biogenesis [GO:0042254]		Noc4p-Nop14p complex [GO:0030692]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]	GO:0005634; GO:0030692; GO:0031965; GO:0032040; GO:0042254
GN002143	GN002143.1	Q9NDJ2	42.6	2248	2982	3198	0.0	1380	DOM_DROME	Chromatin remodeling protein domino (EC 3.6.4.-)	Drosophila melanogaster (Fruit fly)	chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; dendrite guidance [GO:0070983]; dendrite morphogenesis [GO:0048813]; DNA repair-dependent chromatin remodeling [GO:0140861]; hemopoiesis [GO:0030097]; male germ-line stem cell population maintenance [GO:0036098]; negative regulation of gene expression [GO:0010629]; negative regulation of hemocyte proliferation [GO:0035207]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; somatic stem cell population maintenance [GO:0035019]; transcription initiation-coupled chromatin remodeling [GO:0045815]; wing disc pattern formation [GO:0035222]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; histone chaperone activity [GO:0140713]	chromosome [GO:0005694]; histone acetyltransferase complex [GO:0000123]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]	GO:0000123; GO:0000381; GO:0000812; GO:0005524; GO:0005634; GO:0005694; GO:0006325; GO:0006338; GO:0007399; GO:0008094; GO:0010629; GO:0016887; GO:0030097; GO:0035019; GO:0035207; GO:0035222; GO:0035267; GO:0036098; GO:0045815; GO:0045893; GO:0048477; GO:0048813; GO:0070983; GO:0140658; GO:0140713; GO:0140849; GO:0140861
GN002147	GN002147.1	Q9JHI0	35.7	476	479	527	1.45e-64	220	MMP19_MOUSE	Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI)	Mus musculus (Mouse)	collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; luteolysis [GO:0001554]; ovarian follicle development [GO:0001541]; ovulation from ovarian follicle [GO:0001542]; proteolysis [GO:0006508]; response to cAMP [GO:0051591]; response to hormone [GO:0009725]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0001541; GO:0001542; GO:0001554; GO:0004222; GO:0005576; GO:0005886; GO:0006508; GO:0008270; GO:0009725; GO:0030198; GO:0030574; GO:0031012; GO:0051591
GN002150	GN002150.1	Q9UH65	24.6	252	771	585	4.44e-12	73.2	SWP70_HUMAN	Switch-associated protein 70 (SWAP-70)	Homo sapiens (Human)	actin filament bundle assembly [GO:0051017]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of mast cell chemotaxis [GO:0060754]; regulation of protein localization [GO:0032880]; regulation of small GTPase mediated signal transduction [GO:0051056]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	GO:0003677; GO:0005085; GO:0005509; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0007204; GO:0015629; GO:0030027; GO:0030835; GO:0032233; GO:0032880; GO:0033633; GO:0045296; GO:0051017; GO:0051056; GO:0060754; GO:0098794
GN002151	GN002151.1	O60671	67.1	219	221	282	1.01e-104	306	RAD1_HUMAN	Cell cycle checkpoint protein RAD1 (hRAD1) (Rad1-like DNA damage checkpoint protein)	Homo sapiens (Human)	cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; meiotic recombination checkpoint signaling [GO:0051598]; substantia nigra development [GO:0021762]	damaged DNA binding [GO:0003684]	checkpoint clamp complex [GO:0030896]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000077; GO:0003684; GO:0005634; GO:0005654; GO:0005694; GO:0006281; GO:0006974; GO:0021762; GO:0030896; GO:0051598; GO:0071479
GN002155	GN002155.1	Q9VGH7	43.3	1016	954	1193	4.05e-237	705	CLCN2_DROME	Chloride channel protein 2 (ClC-2) (DmClC-2) (Chloride channel-a)	Drosophila melanogaster (Fruit fly)	chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; renal water homeostasis [GO:0003091]; renal water transport [GO:0003097]; transepithelial chloride transport [GO:0030321]; transepithelial water transport [GO:0035377]	chloride channel activity [GO:0005254]; voltage-gated chloride channel activity [GO:0005247]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]	GO:0003091; GO:0003097; GO:0005247; GO:0005254; GO:0005886; GO:0006821; GO:0009925; GO:0015629; GO:0016324; GO:0030321; GO:0035377; GO:1902476
GN002156	GN002156.1	Q9H3D4	37.7	637	590	680	6.51e-104	331	P63_HUMAN	Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)	Homo sapiens (Human)	apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; establishment of skin barrier [GO:0061436]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of somatic stem cell population maintenance [GO:1904674]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein tetramerization [GO:0051262]; regulation of apoptotic process [GO:0042981]; regulation of epidermal cell division [GO:0010482]; spermatogenesis [GO:0007283]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; WW domain binding [GO:0050699]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0002039; GO:0003677; GO:0003682; GO:0003684; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006915; GO:0006974; GO:0007283; GO:0008284; GO:0010482; GO:0030425; GO:0033147; GO:0042771; GO:0042802; GO:0042981; GO:0043565; GO:0045669; GO:0045747; GO:0045892; GO:0045893; GO:0045944; GO:0050699; GO:0051262; GO:0061436; GO:0097371; GO:1902808; GO:1904674; GO:1990841; GO:2000271; GO:2000773; GO:2001235
GN002157	GN002157.1	G5EFC3	27.7	466	451	558	6.06e-46	170	KCNAG_CAEEL	Potassium voltage-gated channel protein egl-36 (Egg-laying defective protein 36)	Caenorhabditis elegans	action potential [GO:0001508]; monoatomic ion transmembrane transport [GO:0034220]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic ion channel activity [GO:0005244]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005244; GO:0005251; GO:0008076; GO:0016020; GO:0032590; GO:0032809; GO:0034220; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN002164	GN002164.1	Q9BZE2	47.0	436	967	481	1.77e-133	413	PUS3_HUMAN	tRNA pseudouridine(38/39) synthase (EC 5.4.99.45) (tRNA pseudouridine synthase 3) (tRNA pseudouridylate synthase 3) (tRNA-uridine isomerase 3)	Homo sapiens (Human)	mRNA pseudouridine synthesis [GO:1990481]; tRNA modification [GO:0006400]; tRNA pseudouridine synthesis [GO:0031119]	pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029]; tRNA pseudouridine(38/39) synthase activity [GO:0160154]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005737; GO:0005829; GO:0006400; GO:0009982; GO:0031119; GO:0106029; GO:0160154; GO:1990481
GN002165	GN002165.1	Q3SZ87	76.2	151	175	185	2.26e-74	224	SSRG_BOVIN	Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma)	Bos taurus (Bovine)	SRP-dependent cotranslational protein targeting to membrane [GO:0006614]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0006614
GN002167	GN002167.1	Q6DBQ8	38.8	209	207	211	3.67e-39	136	CPTP_DANRE	Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1) (CPTP)	Danio rerio (Zebrafish) (Brachydanio rerio)	ceramide 1-phosphate transport [GO:1902389]; ceramide transport [GO:0035627]; intermembrane lipid transfer [GO:0120009]; negative regulation of autophagy [GO:0010507]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]	ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]	GO:0005543; GO:0005640; GO:0005794; GO:0005829; GO:0005886; GO:0010008; GO:0010507; GO:0032691; GO:0035627; GO:0120009; GO:1900226; GO:1902387; GO:1902388; GO:1902389
GN002168	GN002168.1	Q68FT9	52.9	414	439	432	1.73e-154	447	SCLY_RAT	Selenocysteine lyase (EC 4.4.1.16)	Rattus norvegicus (Rat)	lipid metabolic process [GO:0006629]; negative regulation of cellular response to oxidative stress [GO:1900408]; response to insulin [GO:0032868]; selenium compound metabolic process [GO:0001887]	amino acid binding [GO:0016597]; protein homodimerization activity [GO:0042803]; selenocysteine lyase activity [GO:0009000]; vitamin B6 binding [GO:0070279]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]	GO:0001887; GO:0005794; GO:0005829; GO:0006629; GO:0009000; GO:0016597; GO:0032868; GO:0042803; GO:0070279; GO:1900408; GO:1902494
GN002172	GN002172.1	Q2M385	39.3	598	654	716	2.65e-142	434	MPEG1_HUMAN	Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2) [Cleaved into: Macrophage-expressed gene 1 protein, processed form]	Homo sapiens (Human)	antibacterial innate immune response [GO:0140367]; antigen processing and presentation of exogenous peptide antigen [GO:0002478]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; dendritic cell antigen processing and presentation [GO:0002468]	wide pore channel activity [GO:0022829]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; extracellular region [GO:0005576]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagolysosome membrane [GO:0061474]	GO:0002468; GO:0002478; GO:0005576; GO:0022829; GO:0030659; GO:0030670; GO:0031410; GO:0042590; GO:0042742; GO:0045335; GO:0050829; GO:0050830; GO:0061474; GO:0140367
GN002173	GN002173.1	Q5RBP9	38.0	582	727	716	3.53e-141	434	MPEG1_PONAB	Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2) [Cleaved into: Macrophage-expressed gene 1 protein, processed form]	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	antibacterial innate immune response [GO:0140367]; antigen processing and presentation of exogenous peptide antigen [GO:0002478]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; dendritic cell antigen processing and presentation [GO:0002468]	wide pore channel activity [GO:0022829]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagolysosome membrane [GO:0061474]	GO:0002468; GO:0002478; GO:0022829; GO:0030659; GO:0030670; GO:0031410; GO:0042590; GO:0042742; GO:0045335; GO:0050829; GO:0050830; GO:0061474; GO:0140367
GN002178	GN002178.1	Q96EX2	38.9	280	436	444	2.92e-57	197	RNFT2_HUMAN	E3 ubiquitin-protein ligase RNFT2 (RING finger and transmembrane domain-containing protein 2) (Transmembrane protein 118)	Homo sapiens (Human)	positive regulation of ERAD pathway [GO:1904294]	ubiquitin protein ligase activity [GO:0061630]	membrane [GO:0016020]	GO:0016020; GO:0061630; GO:1904294
GN002179	GN002179.1	Q5R5S1	34.4	340	354	621	7.57e-42	157	FBX21_PONAB	F-box only protein 21	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)		DNA binding [GO:0003677]		GO:0003677
GN002180	GN002180.1	Q969V4	52.4	401	402	418	2.23e-134	394	TEKT1_HUMAN	Tektin-1	Homo sapiens (Human)	cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317]		axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005634; GO:0005879; GO:0015630; GO:0030317; GO:0036126; GO:0060271; GO:0060294; GO:0160111
GN002182	GN002182.1	P0C872	49.3	225	296	316	1.91e-77	241	JMJD7_MOUSE	Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7 (EC 1.14.11.63) (EC 3.4.-.-) (JmjC domain-containing protein 7) (Jumonji domain-containing protein 7) (L-lysine (3S)-hydroxylase Jmjd7)	Mus musculus (Mouse)	protein hydroxylation [GO:0018126]	aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; monooxygenase activity [GO:0004497]; peptidyl-lysine 3-dioxygenase activity [GO:0106155]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004175; GO:0004177; GO:0004497; GO:0005634; GO:0005737; GO:0005829; GO:0018126; GO:0106155
GN002184	GN002184.1	P50430	37.8	270	246	528	9.89e-48	168	ARSB_RAT	Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S)	Rattus norvegicus (Rat)	anterior head development [GO:0097065]; autophagy [GO:0006914]; chondroitin sulfate proteoglycan catabolic process [GO:0030207]; colon epithelial cell migration [GO:0061580]; dermatan sulfate proteoglycan catabolic process [GO:0030209]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268]	arylsulfatase activity [GO:0004065]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943]; N-acetylgalactosamine-6-sulfatase activity [GO:0043890]; sulfuric ester hydrolase activity [GO:0008484]	cell surface [GO:0009986]; lysosome [GO:0005764]	GO:0003943; GO:0004065; GO:0005764; GO:0006914; GO:0007584; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0030207; GO:0030209; GO:0043627; GO:0043890; GO:0051597; GO:0061580; GO:0097065
GN002187	GN002187.1	P06760	53.1	614	610	648	1.06e-238	676	BGLR_RAT	Beta-glucuronidase (EC 3.2.1.31)	Rattus norvegicus (Rat)	aorta development [GO:0035904]; articular cartilage development [GO:0061975]; autophagy [GO:0006914]; bone development [GO:0060348]; bone growth [GO:0098868]; bone morphogenesis [GO:0060349]; bone resorption [GO:0045453]; carbohydrate metabolic process [GO:0005975]; cell population proliferation [GO:0008283]; chondrocyte hypertrophy [GO:0003415]; chondrocyte proliferation [GO:0035988]; chondroitin sulfate proteoglycan catabolic process [GO:0030207]; cranial skeletal system development [GO:1904888]; endochondral ossification [GO:0001958]; energy homeostasis [GO:0097009]; gene expression [GO:0010467]; glycosaminoglycan metabolic process [GO:0030203]; growth plate cartilage development [GO:0003417]; growth plate cartilage morphogenesis [GO:0003422]; heparan sulfate proteoglycan catabolic process [GO:0030200]; homeostasis of number of cells [GO:0048872]; hyaluronan catabolic process [GO:0030214]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; lysosome organization [GO:0007040]; multicellular organism growth [GO:0035264]; muscle system process [GO:0003012]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; protein catabolic process [GO:0030163]; protein localization to nucleus [GO:0034504]; protein secretion [GO:0009306]; regulation of catalytic activity [GO:0050790]; regulation of tyrosine phosphorylation of STAT protein [GO:0042509]; response to peptide hormone [GO:0043434]; retinoid metabolic process [GO:0001523]; skeletal system development [GO:0001501]; TORC1 signaling [GO:0038202]	beta-glucuronidase activity [GO:0004566]; carbohydrate binding [GO:0030246]; hydrolase activity [GO:0016787]; protein domain specific binding [GO:0019904]; signaling receptor binding [GO:0005102]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	GO:0001501; GO:0001503; GO:0001523; GO:0001701; GO:0001958; GO:0003012; GO:0003415; GO:0003417; GO:0003422; GO:0004566; GO:0005102; GO:0005576; GO:0005764; GO:0005783; GO:0005975; GO:0006914; GO:0006954; GO:0007040; GO:0008283; GO:0009306; GO:0010467; GO:0016787; GO:0019904; GO:0030163; GO:0030200; GO:0030203; GO:0030207; GO:0030214; GO:0030246; GO:0030316; GO:0034504; GO:0035264; GO:0035904; GO:0035988; GO:0036092; GO:0038202; GO:0042509; GO:0043202; GO:0043434; GO:0045453; GO:0048872; GO:0050790; GO:0060348; GO:0060349; GO:0061975; GO:0097009; GO:0098868; GO:1904888
GN002188	GN002188.1	Q99570	51.6	1398	1360	1358	0.0	1324	PI3R4_HUMAN	Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)	Homo sapiens (Human)	autophagosome maturation [GO:0097352]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; pexophagy [GO:0000425]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; protein phosphorylation [GO:0006468]; protein targeting to lysosome [GO:0006622]; protein targeting to vacuole [GO:0006623]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	autophagosome [GO:0005776]; axoneme [GO:0005930]; cytosol [GO:0005829]; late endosome [GO:0005770]; membrane [GO:0016020]; nucleus-vacuole junction [GO:0071561]; phagocytic vesicle membrane [GO:0030670]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]	GO:0000425; GO:0004672; GO:0004674; GO:0005524; GO:0005770; GO:0005776; GO:0005829; GO:0005930; GO:0006468; GO:0006622; GO:0006623; GO:0010506; GO:0016020; GO:0016236; GO:0016241; GO:0030670; GO:0032465; GO:0032801; GO:0034271; GO:0034272; GO:0035032; GO:0036092; GO:0042149; GO:0043491; GO:0045022; GO:0045324; GO:0071561; GO:0097352; GO:0106310
GN002190	GN002190.1	Q1T7B9	32.7	147	169	177	8.69e-21	87.0	CENPM_CHICK	Centromere protein M (CENP-M)	Gallus gallus (Chicken)			chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]	GO:0000775; GO:0005634
GN002191	GN002191.1	Q0EAB5	27.8	266	247	390	1.11e-10	64.3	5HT1B_HORSE	5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B)	Equus caballus (Horse)	adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; bone remodeling [GO:0046849]; cellular response to alkaloid [GO:0071312]; cellular response to xenobiotic stimulus [GO:0071466]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of serotonin secretion [GO:0014063]; regulation of behavior [GO:0050795]; vasoconstriction [GO:0042310]	G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0004993; GO:0005886; GO:0007187; GO:0007198; GO:0007268; GO:0014063; GO:0030425; GO:0030594; GO:0042310; GO:0045202; GO:0046849; GO:0050795; GO:0071312; GO:0071466
GN002194	GN002194.1	Q99570	51.6	1398	1360	1358	0.0	1324	PI3R4_HUMAN	Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)	Homo sapiens (Human)	autophagosome maturation [GO:0097352]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; pexophagy [GO:0000425]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; protein phosphorylation [GO:0006468]; protein targeting to lysosome [GO:0006622]; protein targeting to vacuole [GO:0006623]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	autophagosome [GO:0005776]; axoneme [GO:0005930]; cytosol [GO:0005829]; late endosome [GO:0005770]; membrane [GO:0016020]; nucleus-vacuole junction [GO:0071561]; phagocytic vesicle membrane [GO:0030670]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]	GO:0000425; GO:0004672; GO:0004674; GO:0005524; GO:0005770; GO:0005776; GO:0005829; GO:0005930; GO:0006468; GO:0006622; GO:0006623; GO:0010506; GO:0016020; GO:0016236; GO:0016241; GO:0030670; GO:0032465; GO:0032801; GO:0034271; GO:0034272; GO:0035032; GO:0036092; GO:0042149; GO:0043491; GO:0045022; GO:0045324; GO:0071561; GO:0097352; GO:0106310
GN002197	GN002197.1	A0A1L5YRA2	69.5	213	219	248	4.38e-100	293	TPIS_SCYPA	Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Allergen Scy p 8) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) (allergen Scy p 8.0101)	Scylla paramamosain (Mud crab)	gluconeogenesis [GO:0006094]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; glycerol catabolic process [GO:0019563]; glycolytic process [GO:0006096]; methylglyoxal biosynthetic process [GO:0019242]	methylglyoxal synthase activity [GO:0008929]; protein homodimerization activity [GO:0042803]; triose-phosphate isomerase activity [GO:0004807]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004807; GO:0005737; GO:0005829; GO:0006094; GO:0006096; GO:0008929; GO:0019242; GO:0019563; GO:0042803; GO:0046166
GN002200	GN002200.1	Q5ZJL7	48.0	369	520	507	2.83e-118	360	DDB2_CHICK	DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2)	Gallus gallus (Chicken)	cellular response to UV [GO:0034644]; nucleotide-excision repair [GO:0006289]; protein ubiquitination [GO:0016567]	damaged DNA binding [GO:0003684]	chromosome [GO:0005694]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0003684; GO:0005634; GO:0005694; GO:0006289; GO:0016567; GO:0031464; GO:0034644; GO:0090734
GN002204	GN002204.1	Q92616	66.0	144	150	2671	6.94e-56	191	GCN1_HUMAN	Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1)	Homo sapiens (Human)	cellular response to amino acid starvation [GO:0034198]; GCN2-mediated signaling [GO:0140469]; protein-RNA covalent cross-linking repair [GO:0160127]; regulation of translation [GO:0006417]; rescue of stalled cytosolic ribosome [GO:0072344]	cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; protein kinase regulator activity [GO:0019887]; protein serine/threonine kinase activator activity [GO:0043539]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; ribosome [GO:0005840]	GO:0003723; GO:0005737; GO:0005829; GO:0005840; GO:0006417; GO:0008135; GO:0016020; GO:0019887; GO:0022626; GO:0034198; GO:0043539; GO:0045296; GO:0060090; GO:0072344; GO:0140469; GO:0160127; GO:0170011
GN002205	GN002205.1	Q96DM1	26.1	357	437	585	7.78e-31	128	PGBD4_HUMAN	PiggyBac transposable element-derived protein 4	Homo sapiens (Human)				
GN002206	GN002206.1	Q92616	40.4	99	104	2671	2.04e-15	73.6	GCN1_HUMAN	Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1)	Homo sapiens (Human)	cellular response to amino acid starvation [GO:0034198]; GCN2-mediated signaling [GO:0140469]; protein-RNA covalent cross-linking repair [GO:0160127]; regulation of translation [GO:0006417]; rescue of stalled cytosolic ribosome [GO:0072344]	cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; protein kinase regulator activity [GO:0019887]; protein serine/threonine kinase activator activity [GO:0043539]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; ribosome [GO:0005840]	GO:0003723; GO:0005737; GO:0005829; GO:0005840; GO:0006417; GO:0008135; GO:0016020; GO:0019887; GO:0022626; GO:0034198; GO:0043539; GO:0045296; GO:0060090; GO:0072344; GO:0140469; GO:0160127; GO:0170011
GN002207	GN002207.1	Q9W704	36.1	155	153	226	2.63e-16	75.9	RIPA_XENLA	RPA-interacting protein A (RPA-interacting protein alpha) (XRIPalpha)	Xenopus laevis (African clawed frog)	protein import into nucleus [GO:0006606]		nucleus [GO:0005634]; PML body [GO:0016605]	GO:0005634; GO:0006606; GO:0016605
GN002208	GN002208.1	Q9JMC1	36.4	354	352	1001	5.86e-59	208	PI5PA_RAT	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.36) (Inositol polyphosphate 5-phosphatase J) (Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase) (EC 3.1.3.56) (Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.56) (Proline-rich inositol polyphosphate 5-phosphatase)	Rattus norvegicus (Rat)	negative regulation of microtubule polymerization [GO:0031115]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; phosphatidylinositol dephosphorylation [GO:0046856]	inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]	cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; growth cone [GO:0030426]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	GO:0001726; GO:0004439; GO:0004445; GO:0005737; GO:0005886; GO:0010977; GO:0030426; GO:0031115; GO:0032587; GO:0033137; GO:0034485; GO:0043005; GO:0043198; GO:0046030; GO:0046856; GO:0052658; GO:0052659
GN002209	GN002209.1	P91685	24.7	878	973	976	1.04e-27	124	GRM_DROME	Metabotropic glutamate receptor (DmGluRA)	Drosophila melanogaster (Fruit fly)	G protein-coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; long-term memory [GO:0007616]; male courtship behavior [GO:0008049]; neuromuscular junction development [GO:0007528]; regulation of synaptic transmission, glutamatergic [GO:0051966]; short-term memory [GO:0007614]; terminal button organization [GO:0072553]	cholesterol binding [GO:0015485]; G protein-coupled receptor activity [GO:0004930]; glutamate binding [GO:0016595]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]	G protein-coupled receptor homodimeric complex [GO:0038038]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0001641; GO:0004930; GO:0005886; GO:0007216; GO:0007528; GO:0007612; GO:0007614; GO:0007616; GO:0008049; GO:0008066; GO:0015485; GO:0016020; GO:0016595; GO:0038038; GO:0045121; GO:0051966; GO:0072553
GN002210	GN002210.1	Q5SSL4	36.7	780	1329	859	1.84e-142	458	ABR_MOUSE	Active breakpoint cluster region-related protein	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; brain development [GO:0007420]; inner ear morphogenesis [GO:0042472]; intracellular signal transduction [GO:0035556]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of blood vessel remodeling [GO:0060313]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular extravasation [GO:0002692]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neutrophil degranulation [GO:0043314]; neuromuscular process controlling balance [GO:0050885]; positive regulation of phagocytosis [GO:0050766]; regulation of vascular permeability [GO:0043114]; response to lipopolysaccharide [GO:0032496]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	axon [GO:0030424]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]	GO:0002692; GO:0005085; GO:0005096; GO:0005829; GO:0005886; GO:0007420; GO:0016020; GO:0030036; GO:0030336; GO:0030424; GO:0032496; GO:0035556; GO:0042472; GO:0043114; GO:0043197; GO:0043314; GO:0045202; GO:0050728; GO:0050766; GO:0050804; GO:0050885; GO:0060313; GO:0090630; GO:0098685; GO:0098978; GO:0099092
GN002211	GN002211.1	P35432	46.8	370	373	375	2.20e-116	345	ACT1_ECHGR	Actin-1 (EC 3.6.4.-)	Echinococcus granulosus (Hydatid tapeworm)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN002212	GN002212.1	P02578	60.8	372	379	375	7.06e-166	471	ACT1_ACACA	Actin-1 (EC 3.6.4.-)	Acanthamoeba castellanii (Amoeba)	cell morphogenesis [GO:0000902]; phagocytosis [GO:0006909]; plasma membrane repair [GO:0001778]; response to cAMP [GO:0051591]	ATP hydrolysis activity [GO:0016887]	cell pole [GO:0060187]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; early phagosome [GO:0032009]; intranuclear rod [GO:0061836]; lamellipodium [GO:0030027]; phagocytic cup [GO:0001891]; phagolysosome [GO:0032010]	GO:0000902; GO:0001778; GO:0001891; GO:0005911; GO:0006909; GO:0016887; GO:0030027; GO:0030864; GO:0032009; GO:0032010; GO:0051591; GO:0060187; GO:0061836
GN002213	GN002213.1	P45886	52.9	376	379	376	2.18e-138	402	ACT3_BACDO	Actin-3, muscle-specific (EC 3.6.4.-)	Bactrocera dorsalis (Oriental fruit fly) (Dacus dorsalis)	anatomical structure formation involved in morphogenesis [GO:0048646]; cell development [GO:0048468]	ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887; GO:0048468; GO:0048646
GN002214	GN002214.1	Q8T062	38.4	617	630	1040	3.14e-150	463	NEP4_DROME	Neprilysin-4 (EC 3.4.24.11)	Drosophila melanogaster (Fruit fly)	protein processing [GO:0016485]; proteolysis [GO:0006508]	endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]	GO:0004175; GO:0004222; GO:0005576; GO:0005737; GO:0005886; GO:0006508; GO:0008237; GO:0016020; GO:0016485; GO:0016529
GN002216	GN002216.1	P04069	45.3	296	417	303	8.90e-85	264	CBPB_ASTAS	Carboxypeptidase B (EC 3.4.17.2)	Astacus astacus (Noble crayfish) (Astacus fluviatilis)	proteolysis [GO:0006508]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0004181; GO:0005576; GO:0006508; GO:0008270
GN002218	GN002218.1	Q5PQY6	65.1	743	743	840	0.0	909	LONP2_DANRE	Lon protease homolog 2, peroxisomal (EC 3.4.21.53)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein import into peroxisome matrix [GO:0016558]; protein processing [GO:0016485]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein targeting to peroxisome [GO:0006625]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	peroxisomal matrix [GO:0005782]	GO:0004176; GO:0004252; GO:0005524; GO:0005782; GO:0006515; GO:0006625; GO:0008233; GO:0016485; GO:0016558; GO:0016887
GN002220	GN002220.1	Q5XJS5	45.2	219	236	323	1.17e-63	204	THOC6_DANRE	THO complex subunit 6 homolog (WD repeat-containing protein 58)	Danio rerio (Zebrafish) (Brachydanio rerio)	mRNA export from nucleus [GO:0006406]		nuclear speck [GO:0016607]; transcription export complex [GO:0000346]	GO:0000346; GO:0006406; GO:0016607
GN002222	GN002222.1	Q8WN96	24.1	511	731	2701	1.92e-32	139	ITPR2_BOVIN	Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)	Bos taurus (Bovine)	release of sequestered calcium ion into cytosol [GO:0051209]	calcium ion binding [GO:0005509]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]; phosphatidylinositol binding [GO:0035091]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; sarcoplasmic reticulum [GO:0016529]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]	GO:0005220; GO:0005509; GO:0005789; GO:0005791; GO:0005886; GO:0016529; GO:0030658; GO:0030667; GO:0035091; GO:0051209; GO:0070679
GN002229	GN002229.1	Q8C1R0	38.3	287	624	372	2.11e-52	187	TSSK5_MOUSE	Testis-specific serine/threonine-protein kinase 5 (TSK-5) (TSSK-5) (Testis-specific kinase 5) (EC 2.7.11.1)	Mus musculus (Mouse)		ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]		GO:0000287; GO:0004674; GO:0005524; GO:0106310
GN002231	GN002231.1	Q9D305	33.7	86	210	217	4.18e-09	57.8	THAP2_MOUSE	THAP domain-containing protein 2	Mus musculus (Mouse)			nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730
GN002235	GN002235.1	Q0P6D2	28.8	396	416	419	4.65e-42	156	DIK1C_HUMAN	Divergent protein kinase domain 1C (Protein FAM69C)	Homo sapiens (Human)		protein serine/threonine kinase activity [GO:0004674]	endoplasmic reticulum membrane [GO:0005789]	GO:0004674; GO:0005789
GN002238	GN002238.1	Q6B4Z5	29.5	146	1270	801	7.86e-11	70.5	ZFY_PANTR	Zinc finger Y-chromosomal protein	Pan troglodytes (Chimpanzee)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0006357; GO:0043565; GO:0046872
GN002242	GN002242.1	Q5U2W4	25.2	349	351	340	1.13e-24	105	CENPN_RAT	Centromere protein N (CENP-N)	Rattus norvegicus (Rat)	CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]		chromosome, centromeric region [GO:0000775]; nucleoplasm [GO:0005654]	GO:0000775; GO:0005654; GO:0007059; GO:0034080
GN002244	GN002244.1	Q9W4P5	80.4	341	373	350	5.25e-205	569	VA0D1_DROME	V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (V-ATPase 39 kDa subunit) (Vacuolar H+ ATPase subunit AC39-1) (Vacuolar proton pump subunit d 1)	Drosophila melanogaster (Fruit fly)	cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; proton transmembrane transport [GO:1902600]; terminal branching, open tracheal system [GO:0007430]; vacuolar acidification [GO:0007035]; vacuolar transport [GO:0007034]	proton-transporting ATPase activity, rotational mechanism [GO:0046961]	early endosome [GO:0005769]; plasma membrane [GO:0005886]; plasma membrane proton-transporting V-type ATPase complex [GO:0033181]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	GO:0000220; GO:0005769; GO:0005886; GO:0006879; GO:0007034; GO:0007035; GO:0007430; GO:0016471; GO:0033181; GO:0036295; GO:0046961; GO:1902600
GN002254	GN002254.1	Q6Y288	50.6	445	493	498	2.73e-153	449	B3GLT_HUMAN	Beta-1,3-glucosyltransferase (Beta3Glc-T) (EC 2.4.1.-) (Beta 3-glucosyltransferase) (Beta-3-glycosyltransferase-like)	Homo sapiens (Human)	protein O-linked glycosylation via fucose [GO:0036066]	acetylglucosaminyltransferase activity [GO:0008375]; glycosyltransferase activity [GO:0016757]; O-fucosylpeptide 3-beta-glucosyltransferase activity [GO:0160265]	endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0008375; GO:0016757; GO:0036066; GO:0160265
GN002255	GN002255.1	Q23023	37.8	978	982	856	1.93e-155	483	UNC51_CAEEL	Serine/threonine-protein kinase unc-51 (EC 2.7.11.1) (Uncoordinated protein 51)	Caenorhabditis elegans	apoptotic cell clearance [GO:0043277]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; axon extension [GO:0048675]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cell migration [GO:0016477]; dauer larval development [GO:0040024]; determination of adult lifespan [GO:0008340]; embryo development ending in birth or egg hatching [GO:0009792]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; nematode male tail tip morphogenesis [GO:0045138]; piecemeal microautophagy of the nucleus [GO:0034727]; programmed cell death [GO:0012501]; regulation of autophagy [GO:0010506]; regulation of axon extension [GO:0030516]; regulation of cell size [GO:0008361]; regulation of multicellular organism growth [GO:0040014]; regulation of protein localization [GO:0032880]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	autophagosome [GO:0005776]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; serine/threonine protein kinase complex [GO:1902554]	GO:0000045; GO:0000407; GO:0000423; GO:0004674; GO:0005524; GO:0005737; GO:0005776; GO:0005829; GO:0006914; GO:0007409; GO:0007411; GO:0008340; GO:0008361; GO:0009792; GO:0010506; GO:0012501; GO:0016236; GO:0016477; GO:0030424; GO:0030516; GO:0032880; GO:0034045; GO:0034727; GO:0040014; GO:0040024; GO:0042594; GO:0043005; GO:0043025; GO:0043277; GO:0045138; GO:0048675; GO:0061709; GO:0106310; GO:1902554
GN002256	GN002256.1	O88884	43.4	281	773	854	2.98e-68	244	AKAP1_RAT	A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 121 kDa) (AKAP 121) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84)	Rattus norvegicus (Rat)	antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; cellular response to cAMP [GO:0071320]; cellular response to peptide hormone stimulus [GO:0071375]; intracellular protein localization [GO:0008104]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of dephosphorylation [GO:0035305]; negative regulation of protein import into nucleus [GO:0042308]; positive regulation of meiotic cell cycle process involved in oocyte maturation [GO:1904146]	beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrial crista [GO:0030061]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; postsynaptic membrane [GO:0045211]; postsynaptic specialization, intracellular component [GO:0099091]	GO:0003723; GO:0005737; GO:0005739; GO:0005741; GO:0005811; GO:0006915; GO:0008017; GO:0008104; GO:0016020; GO:0019901; GO:0030061; GO:0031594; GO:0034237; GO:0035305; GO:0042308; GO:0045211; GO:0048487; GO:0061052; GO:0071320; GO:0071375; GO:0099091; GO:0140374; GO:1904146
GN002259	GN002259.1	A2VDX7	41.5	289	390	370	2.76e-69	225	EXO5_BOVIN	Exonuclease V (Exo V) (EC 3.1.-.-) (Defects in morphology protein 1 homolog)	Bos taurus (Bovine)	interstrand cross-link repair [GO:0036297]	4 iron, 4 sulfur cluster binding [GO:0051539]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0016607; GO:0036297; GO:0045145; GO:0051539
GN002266	GN002266.1	Q08J23	48.1	675	764	767	1.15e-209	613	NSUN2_HUMAN	RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4)	Homo sapiens (Human)	hair follicle maturation [GO:0048820]; mRNA processing [GO:0006397]; regulation of mRNA export from nucleus [GO:0010793]; regulation of stem cell differentiation [GO:2000736]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA stabilization [GO:0036416]	mRNA (cytidine-5-)-methyltransferase activity [GO:0062152]; RNA binding [GO:0003723]; tRNA (cytidine-N5)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0000049; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005739; GO:0005819; GO:0006397; GO:0006400; GO:0010793; GO:0016428; GO:0030488; GO:0036416; GO:0048820; GO:0062152; GO:0070062; GO:2000736
GN002267	GN002267.1	Q8TBB5	43.6	459	544	520	7.10e-132	397	KLDC4_HUMAN	Kelch domain-containing protein 4	Homo sapiens (Human)				
GN002268	GN002268.1	Q9UH36	38.5	265	282	339	1.54e-50	172	SRR1L_HUMAN	SRR1-like protein (SRR1 domain-containing protein)	Homo sapiens (Human)	regulation of circadian rhythm [GO:0042752]; regulation of heme biosynthetic process [GO:0070453]		cytoplasm [GO:0005737]	GO:0005737; GO:0042752; GO:0070453
GN002269	GN002269.1	Q9Y0H4	58.0	910	825	949	1.10e-291	831	SUDX_DROME	E3 ubiquitin-protein ligase Su(dx) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase Su(dx)) (Protein suppressor of deltex)	Drosophila melanogaster (Fruit fly)	imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; lipid storage [GO:0019915]; negative regulation of hippo signaling [GO:0035331]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of endocytosis [GO:0045807]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; pupal development [GO:0035209]; R8 cell development [GO:0045463]; receptor internalization [GO:0031623]; regulation of protein localization [GO:0032880]; wing disc dorsal/ventral pattern formation [GO:0048190]	Notch binding [GO:0005112]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]	GO:0004842; GO:0005112; GO:0005737; GO:0005938; GO:0006622; GO:0008586; GO:0008587; GO:0016348; GO:0016567; GO:0019915; GO:0031623; GO:0032880; GO:0035209; GO:0035331; GO:0043161; GO:0045463; GO:0045746; GO:0045807; GO:0045879; GO:0048190; GO:0061630
GN002274	GN002274.1	Q5RDQ8	23.6	462	1348	922	6.92e-22	106	GRM7_PONAB	Metabotropic glutamate receptor 7 (mGluR7)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; axon development [GO:0061564]	glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]; protein dimerization activity [GO:0046983]	plasma membrane [GO:0005886]	GO:0001642; GO:0005886; GO:0007196; GO:0008066; GO:0046983; GO:0061564
GN002275	GN002275.1	A7S8T5	69.0	300	312	312	4.54e-127	368	CCD42_NEMVE	Coiled-coil domain-containing protein 42 homolog	Nematostella vectensis (Starlet sea anemone)			cytoskeleton [GO:0005856]	GO:0005856
GN002276	GN002276.1	Q640K1	25.7	869	883	720	4.77e-71	252	NCDN_XENLA	Neurochondrin	Xenopus laevis (African clawed frog)	neuron projection development [GO:0031175]; regulation of neuronal synaptic plasticity [GO:0048168]		cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]	GO:0005829; GO:0030425; GO:0031175; GO:0043025; GO:0048168; GO:0098794
GN002277	GN002277.1	Q9P243	25.2	742	1277	1243	3.77e-59	227	ZFAT_HUMAN	Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406)	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0005829; GO:0006355
GN002278	GN002278.1	Q9NS37	40.9	132	346	354	6.18e-16	81.3	ZHANG_HUMAN	CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei)	Homo sapiens (Human)	ATF6-mediated unfolded protein response [GO:0036500]; integrated stress response signaling [GO:0140467]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000785; GO:0000981; GO:0003677; GO:0005634; GO:0006357; GO:0009615; GO:0036500; GO:0042802; GO:0045814; GO:0045892; GO:0045944; GO:0090575; GO:0140467
GN002281	GN002281.1	Q8C3S2	32.9	1211	1170	1079	6.71e-167	526	TNG6_MOUSE	Transport and Golgi organization protein 6 homolog (Transmembrane and coiled-coil domain-containing protein 7)	Mus musculus (Mouse)	protein secretion [GO:0009306]		membrane [GO:0016020]	GO:0009306; GO:0016020
GN002289	GN002289.1	Q5RC70	39.7	554	561	559	1.04e-125	383	DJC11_PONAB	DnaJ homolog subfamily C member 11	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	cristae formation [GO:0042407]		MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]	GO:0005741; GO:0042407; GO:0140275
GN002291	GN002291.1	P46467	73.9	444	443	444	3.37e-228	635	VPS4B_MOUSE	Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Suppressor of K(+) transport growth defect 1) (Protein SKD1)	Mus musculus (Mouse)	angiogenesis [GO:0001525]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; canonical Wnt signaling pathway [GO:0060070]; central nervous system development [GO:0007417]; cholesterol transport [GO:0030301]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ESCRT III complex disassembly [GO:1904903]; establishment of blood-brain barrier [GO:0060856]; late endosomal microautophagy [GO:0061738]; late endosome to lysosome transport via multivesicular body sorting pathway [GO:0061764]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; negative regulation of exosomal secretion [GO:1903542]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of centriole elongation [GO:1903724]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; potassium ion transport [GO:0006813]; protein depolymerization [GO:0051261]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; response to lipid [GO:0033993]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuolar transport [GO:0007034]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	ATPase complex [GO:1904949]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Flemming body [GO:0090543]; late endosome membrane [GO:0031902]; midbody [GO:0030496]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]	GO:0000922; GO:0001525; GO:0001778; GO:0005524; GO:0005634; GO:0005643; GO:0005737; GO:0005768; GO:0005813; GO:0005829; GO:0005886; GO:0006813; GO:0006914; GO:0006997; GO:0007032; GO:0007034; GO:0007080; GO:0007417; GO:0010008; GO:0010824; GO:0010971; GO:0016197; GO:0016887; GO:0030301; GO:0030496; GO:0031468; GO:0031902; GO:0032510; GO:0033993; GO:0036258; GO:0039702; GO:0042802; GO:0042803; GO:0043162; GO:0044877; GO:0046761; GO:0051261; GO:0060070; GO:0060856; GO:0061738; GO:0061764; GO:0061952; GO:0071985; GO:0090148; GO:0090543; GO:0090611; GO:0097352; GO:1901673; GO:1903542; GO:1903543; GO:1903724; GO:1904903; GO:1904949
GN002292	GN002292.1	P22758	35.6	725	828	836	8.85e-152	468	TGM1_RABIT	Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) [Cleaved into: Protein-glutamine gamma-glutamyltransferase K 67 kDa chain; Protein-glutamine gamma-glutamyltransferase K 33 kDa chain]	Oryctolagus cuniculus (Rabbit)	animal organ development [GO:0048513]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838]	protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0003810; GO:0005829; GO:0005886; GO:0010838; GO:0045787; GO:0048513
GN002296	GN002296.1	Q99442	53.8	91	193	399	1.07e-24	102	SEC62_HUMAN	Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1)	Homo sapiens (Human)	cotranslational protein targeting to membrane [GO:0006613]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]; reticulophagy [GO:0061709]	signaling receptor activity [GO:0038023]; transmembrane protein transporter activity [GO:0008320]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791]	GO:0005783; GO:0005789; GO:0005791; GO:0006613; GO:0006620; GO:0008320; GO:0016020; GO:0031204; GO:0038023; GO:0061709
GN002297	GN002297.1	P42346	65.1	2540	2478	2549	0.0	3197	MTOR_RAT	Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin target protein 1) (RAPT1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2)	Rattus norvegicus (Rat)	'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; behavioral response to pain [GO:0048266]; cardiac cell development [GO:0055006]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle tissue development [GO:0048738]; cell projection organization [GO:0030030]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to methionine [GO:0061431]; cellular response to nutrient [GO:0031670]; cellular response to nutrient levels [GO:0031669]; cellular response to starvation [GO:0009267]; energy reserve metabolic process [GO:0006112]; germ cell development [GO:0007281]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; inflammatory response [GO:0006954]; long-term memory [GO:0007616]; maternal process involved in female pregnancy [GO:0060135]; mRNA stabilization [GO:0048255]; multicellular organism growth [GO:0035264]; negative regulation of autophagy [GO:0010507]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cell size [GO:0045792]; negative regulation of cholangiocyte apoptotic process [GO:1904193]; negative regulation of iodide transmembrane transport [GO:1904213]; negative regulation of lysosome organization [GO:1905672]; negative regulation of macroautophagy [GO:0016242]; negative regulation of muscle atrophy [GO:0014736]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; neuronal action potential [GO:0019228]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of cellular senescence [GO:2000774]; positive regulation of cholangiocyte proliferation [GO:1904056]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of eating behavior [GO:1904000]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of granulosa cell proliferation [GO:1904197]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neuron maturation [GO:0014042]; positive regulation of neuron projection development [GO:0010976]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process [GO:0062027]; positive regulation of skeletal muscle hypertrophy [GO:1904206]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; post-embryonic development [GO:0009791]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of brown fat cell differentiation [GO:0090335]; regulation of carbohydrate metabolic process [GO:0006109]; regulation of carbohydrate utilization [GO:0043610]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; regulation of circadian rhythm [GO:0042752]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of locomotor rhythm [GO:1904059]; regulation of lysosome organization [GO:1905671]; regulation of membrane permeability [GO:0090559]; regulation of myelination [GO:0031641]; regulation of osteoclast differentiation [GO:0045670]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of protein kinase activity [GO:0045859]; regulation of protein phosphorylation [GO:0001932]; regulation of response to food [GO:0032095]; regulation of translation at synapse, modulating synaptic transmission [GO:0099547]; response to activity [GO:0014823]; response to amino acid [GO:0043200]; response to cocaine [GO:0042220]; response to heat [GO:0009408]; response to insulin [GO:0032868]; response to nutrient levels [GO:0031667]; response to virus [GO:0009615]; social behavior [GO:0035176]; spinal cord development [GO:0021510]; T-helper 1 cell lineage commitment [GO:0002296]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; TORC2 signaling [GO:0038203]; visual learning [GO:0008542]; voluntary musculoskeletal movement [GO:0050882]	identical protein binding [GO:0042802]; inositol hexakisphosphate binding [GO:0000822]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphoprotein binding [GO:0051219]; protein domain specific binding [GO:0019904]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; ribosome binding [GO:0043022]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TFIIIC-class transcription factor complex binding [GO:0001156]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic cytosol [GO:0099524]; protein-containing complex [GO:0032991]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]	GO:0000139; GO:0000822; GO:0001002; GO:0001003; GO:0001006; GO:0001156; GO:0001558; GO:0001932; GO:0001933; GO:0001934; GO:0001938; GO:0002296; GO:0003007; GO:0003179; GO:0004672; GO:0004674; GO:0004713; GO:0004715; GO:0005634; GO:0005635; GO:0005737; GO:0005741; GO:0005764; GO:0005765; GO:0005783; GO:0005789; GO:0005794; GO:0005829; GO:0005886; GO:0005979; GO:0006109; GO:0006112; GO:0006207; GO:0006468; GO:0006954; GO:0007281; GO:0007616; GO:0008361; GO:0008542; GO:0009267; GO:0009408; GO:0009615; GO:0009791; GO:0010506; GO:0010507; GO:0010592; GO:0010718; GO:0010831; GO:0010976; GO:0012505; GO:0014042; GO:0014736; GO:0014823; GO:0016020; GO:0016242; GO:0016605; GO:0018105; GO:0018107; GO:0019228; GO:0019901; GO:0019904; GO:0021510; GO:0030030; GO:0030425; GO:0030838; GO:0031397; GO:0031641; GO:0031667; GO:0031669; GO:0031670; GO:0031929; GO:0031931; GO:0031932; GO:0031998; GO:0032095; GO:0032868; GO:0032869; GO:0032956; GO:0032991; GO:0034198; GO:0035176; GO:0035264; GO:0038202; GO:0038203; GO:0042220; GO:0042752; GO:0042802; GO:0043022; GO:0043025; GO:0043200; GO:0043491; GO:0043525; GO:0043610; GO:0044325; GO:0045335; GO:0045429; GO:0045670; GO:0045727; GO:0045792; GO:0045859; GO:0045860; GO:0045945; GO:0045948; GO:0046777; GO:0046889; GO:0048255; GO:0048266; GO:0048661; GO:0048714; GO:0048738; GO:0050731; GO:0050769; GO:0050882; GO:0051219; GO:0051496; GO:0051549; GO:0051896; GO:0051897; GO:0055006; GO:0055013; GO:0060048; GO:0060135; GO:0060252; GO:0060999; GO:0061051; GO:0061431; GO:0062027; GO:0070885; GO:0071230; GO:0071233; GO:0071456; GO:0090335; GO:0090559; GO:0098978; GO:0099524; GO:0099547; GO:0106310; GO:1900029; GO:1900181; GO:1901838; GO:1903691; GO:1904000; GO:1904037; GO:1904056; GO:1904059; GO:1904193; GO:1904197; GO:1904206; GO:1904213; GO:1905671; GO:1905672; GO:1990253; GO:2000060; GO:2000774; GO:2000785
GN002298	GN002298.1	Q8C8H8	26.7	404	1150	661	1.46e-27	123	KY_MOUSE	Kyphoscoliosis peptidase (EC 3.4.-.-)	Mus musculus (Mouse)	muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]	GO:0005737; GO:0005856; GO:0007517; GO:0007528; GO:0030018
GN002300	GN002300.1	A2BG43	36.0	111	162	209	6.67e-17	77.4	GLTP_DANRE	Glycolipid transfer protein (GLTP)	Danio rerio (Zebrafish) (Brachydanio rerio)	ceramide transport [GO:0035627]; intermembrane lipid transfer [GO:0120009]	ceramide 1-phosphate binding [GO:1902387]; lipid transfer activity [GO:0120013]	cytosol [GO:0005829]	GO:0005829; GO:0035627; GO:0120009; GO:0120013; GO:1902387
GN002301	GN002301.1	D3ZL52	39.9	233	244	234	8.08e-42	145	SESQ1_RAT	Sesquipedalian-1 (Ses1) (27 kDa inositol polyphosphate phosphatase interacting protein A) (IPIP27A) (PH domain-containing endocytic trafficking adaptor 1)	Rattus norvegicus (Rat)	endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]	protein homodimerization activity [GO:0042803]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]	GO:0001881; GO:0005769; GO:0005802; GO:0005829; GO:0007032; GO:0030136; GO:0042147; GO:0042803; GO:0055037
GN002302	GN002302.1	O14578	34.2	2151	2234	2027	3.66e-223	728	CTRO_HUMAN	Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21)	Homo sapiens (Human)	generation of neurons [GO:0048699]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; negative regulation of hippo signaling [GO:0035331]; positive regulation of cytokinesis [GO:0032467]; regulation of actin cytoskeleton organization [GO:0032956]	ATP binding [GO:0005524]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase inhibitor activity [GO:0030291]; scaffold protein binding [GO:0097110]; transcription coactivator binding [GO:0001223]	cytosol [GO:0005829]; membrane [GO:0016020]	GO:0000278; GO:0000281; GO:0001223; GO:0004674; GO:0005524; GO:0005829; GO:0016020; GO:0019901; GO:0030165; GO:0030291; GO:0032467; GO:0032956; GO:0035331; GO:0048699; GO:0097110; GO:0106310
GN002303	GN002303.1	O62146	45.3	53	59	582	4.57e-11	58.9	PLBL2_CAEEL	Putative phospholipase B-like 2 (EC 3.1.1.-) (LAMA-like protein 2) (Lamina ancestor homolog 2)	Caenorhabditis elegans		glycerophospholipase activity [GO:0004620]	extracellular region [GO:0005576]	GO:0004620; GO:0005576
GN002304	GN002304.1	Q9R1S4	50.4	137	412	267	7.75e-21	94.7	XBP1_RAT	X-box-binding protein 1 (Hepatocarcinogenesis-related transcription factor) (HTF) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]	Rattus norvegicus (Rat)	adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; cellular response to amino acid stimulus [GO:0071230]; cellular response to antibiotic [GO:0071236]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cholesterol homeostasis [GO:0042632]; endoplasmic reticulum unfolded protein response [GO:0030968]; endothelial cell proliferation [GO:0001935]; epithelial cell maturation [GO:0002070]; epithelial cell maturation involved in salivary gland development [GO:0060691]; exocrine pancreas development [GO:0031017]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; intracellular triglyceride homeostasis [GO:0035356]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; liver development [GO:0001889]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron development [GO:0048666]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular wound healing [GO:0035470]; protein destabilization [GO:0031648]; regulation of autophagy [GO:0010506]; regulation of cell growth [GO:0001558]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein stability [GO:0031647]; regulation of transcription by RNA polymerase II [GO:0006357]; response to electrical stimulus [GO:0051602]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; serotonin secretion, neurotransmission [GO:0060096]; sterol homeostasis [GO:0055092]; transcription by RNA polymerase II [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	chromatin DNA binding [GO:0031490]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; presynapse [GO:0098793]	GO:0000122; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0000987; GO:0001228; GO:0001525; GO:0001558; GO:0001889; GO:0001934; GO:0001935; GO:0002020; GO:0002070; GO:0002639; GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0005783; GO:0005789; GO:0005829; GO:0006355; GO:0006357; GO:0006366; GO:0006511; GO:0007584; GO:0008284; GO:0009410; GO:0010506; GO:0010508; GO:0010832; GO:0016020; GO:0019901; GO:0030335; GO:0030512; GO:0030968; GO:0031017; GO:0031490; GO:0031625; GO:0031647; GO:0031648; GO:0031670; GO:0032008; GO:0032755; GO:0032869; GO:0034599; GO:0034976; GO:0035356; GO:0035470; GO:0035924; GO:0036312; GO:0036498; GO:0042149; GO:0042307; GO:0042593; GO:0042632; GO:0042802; GO:0042826; GO:0043066; GO:0043491; GO:0043565; GO:0044389; GO:0045348; GO:0045579; GO:0045582; GO:0045600; GO:0045766; GO:0045944; GO:0046982; GO:0048010; GO:0048666; GO:0051602; GO:0051897; GO:0055089; GO:0055092; GO:0060096; GO:0060392; GO:0060612; GO:0060691; GO:0061629; GO:0070059; GO:0070373; GO:0071222; GO:0071230; GO:0071236; GO:0071332; GO:0071333; GO:0071353; GO:0071375; GO:0071498; GO:0071499; GO:0098793; GO:1900017; GO:1900100; GO:1900102; GO:1901800; GO:1901985; GO:1902236; GO:1903489; GO:1904707; GO:1904754; GO:1990418; GO:1990830; GO:1990837; GO:2000347; GO:2000353
GN002313	GN002313.1	Q9BWW7	63.1	84	435	348	7.74e-27	113	SCRT1_HUMAN	Transcriptional repressor scratch 1 (Scratch homolog 1 zinc finger protein) (SCRT) (Scratch 1) (hScrt)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	nuclear body [GO:0016604]; nucleus [GO:0005634]	GO:0000122; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0003700; GO:0005634; GO:0006355; GO:0016604; GO:0043565; GO:1990837
GN002314	GN002314.1	B3EWY6	29.6	142	237	386	3.91e-15	77.0	SAAR1_ACRMI	Skeletal aspartic acid-rich protein 1	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]	GO:0005576
GN002315	GN002315.1	B3EWY7	28.7	195	230	359	1.57e-15	77.8	ASOMP_ACRMI	Acidic skeletal organic matrix protein (Acidic SOMP)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]	GO:0005576
GN002316	GN002316.1	Q4V8B3	32.0	1016	1014	987	1.98e-154	486	MED24_RAT	Mediator of RNA polymerase II transcription subunit 24 (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4)	Rattus norvegicus (Rat)	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; stem cell population maintenance [GO:0019827]; transcription by RNA polymerase II [GO:0006366]	histone acetyltransferase activity [GO:0004402]; nuclear thyroid hormone receptor binding [GO:0046966]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	mediator complex [GO:0016592]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0003712; GO:0003713; GO:0004402; GO:0005634; GO:0006366; GO:0016567; GO:0016592; GO:0019827; GO:0044877; GO:0045893; GO:0046966; GO:0060261
GN002317	GN002317.1	Q8R3F5	45.2	314	359	381	7.66e-85	265	FABD_MOUSE	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase)	Mus musculus (Mouse)	fatty acid biosynthetic process [GO:0006633]; mitochondrial small ribosomal subunit assembly [GO:0180026]	[acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; RNA folding chaperone [GO:0140691]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004314; GO:0005739; GO:0005759; GO:0006633; GO:0140691; GO:0180026
GN002318	GN002318.1	Q5XK83	69.0	197	195	858	1.73e-92	290	MCM4A_XENLA	DNA replication licensing factor mcm4-A (EC 3.6.4.12) (CDC21 homolog-A) (Minichromosome maintenance protein 4-A) (xMCM4-A) (P1-CDC21-A) (p98)	Xenopus laevis (African clawed frog)	cell cycle DNA replication [GO:0044786]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]	chromatin [GO:0000785]; chromosome [GO:0005694]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; nucleus [GO:0005634]	GO:0000727; GO:0000785; GO:0003682; GO:0003697; GO:0005524; GO:0005634; GO:0005694; GO:0006271; GO:0016887; GO:0017116; GO:0030174; GO:0042555; GO:0044786; GO:0071162; GO:1902975
GN002319	GN002319.1	P30664	70.4	284	286	863	1.01e-131	397	MCM4B_XENLA	DNA replication licensing factor mcm4-B (EC 3.6.4.12) (CDC21 homolog-B) (Minichromosome maintenance protein 4-B) (xMCM4-B) (P1-CDC21-B)	Xenopus laevis (African clawed frog)	cell cycle DNA replication [GO:0044786]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; premeiotic DNA replication [GO:0006279]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]	chromatin [GO:0000785]; chromosome [GO:0005694]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; nucleus [GO:0005634]	GO:0000727; GO:0000785; GO:0003682; GO:0003697; GO:0005524; GO:0005634; GO:0005694; GO:0006271; GO:0006279; GO:0016887; GO:0017116; GO:0030174; GO:0042555; GO:0044786; GO:0071162; GO:1902975
GN002321	GN002321.1	Q68CZ1	37.9	1370	1350	1315	1.18e-260	783	FTM_HUMAN	Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein)	Homo sapiens (Human)	negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]; retinal rod cell development [GO:0046548]	thromboxane A2 receptor binding [GO:0031870]	axoneme [GO:0005930]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; NPHP complex [GO:1990957]; photoreceptor connecting cilium [GO:0032391]	GO:0005737; GO:0005813; GO:0005829; GO:0005911; GO:0005923; GO:0005929; GO:0005930; GO:0031870; GO:0032391; GO:0035869; GO:0036064; GO:0045744; GO:0046548; GO:1904491; GO:1905515; GO:1990957
GN002328	GN002328.1	Q52556	34.4	532	589	528	1.98e-85	278	LPAKS_PSES9	Linear primary-alkylsulfatase (EC 3.1.6.21) (SDSase) (Type III linear primary-alkylsulfatase)	Pseudomonas sp. (strain ATCC 19151)	dodecyl sulfate metabolic process [GO:0018909]	linear primary-alkylsulfatase activity [GO:0018741]; protein dimerization activity [GO:0046983]		GO:0018741; GO:0018909; GO:0046983
GN002331	GN002331.1	Q6NXG1	45.5	706	726	681	9.86e-184	542	ESRP1_HUMAN	Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A)	Homo sapiens (Human)	regulation of inner ear auditory receptor cell fate specification [GO:0042669]; regulation of RNA splicing [GO:0043484]	mRNA binding [GO:0003729]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0003729; GO:0005634; GO:0005654; GO:0016604; GO:0042669; GO:0043484; GO:1990904
GN002333	GN002333.1	P55041	44.4	72	241	295	4.16e-12	67.8	GEM_MOUSE	GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR)	Mus musculus (Mouse)	chromosome organization [GO:0051276]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]	calcium channel regulator activity [GO:0005246]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	cytoplasmic side of plasma membrane [GO:0009898]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle midzone [GO:0051233]	GO:0000278; GO:0000287; GO:0003924; GO:0005246; GO:0005525; GO:0005634; GO:0005886; GO:0009898; GO:0019003; GO:0030496; GO:0051233; GO:0051276; GO:0051310; GO:0072686
GN002334	GN002334.1	Q9BYN7	40.9	618	931	854	1.14e-98	332	ZN341_HUMAN	Zinc finger protein 341	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001216; GO:0003677; GO:0005634; GO:0006355
GN002335	GN002335.1	Q32KJ6	68.4	494	513	524	1.08e-264	733	GALNS_RAT	N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase)	Rattus norvegicus (Rat)	chondroitin sulfate proteoglycan catabolic process [GO:0030207]	arylsulfatase activity [GO:0004065]; N-acetylgalactosamine-6-sulfatase activity [GO:0043890]; sulfuric ester hydrolase activity [GO:0008484]	lysosome [GO:0005764]	GO:0004065; GO:0005764; GO:0008484; GO:0030207; GO:0043890
GN002339	GN002339.1	Q5EA66	44.0	193	572	344	6.04e-51	181	ANGL7_BOVIN	Angiopoietin-related protein 7 (Angiopoietin-like protein 7)	Bos taurus (Bovine)	blood coagulation [GO:0007596]; negative regulation of vasculature development involved in avascular cornea development in camera-type eye [GO:1901346]; regulation of extracellular matrix organization [GO:1903053]	identical protein binding [GO:0042802]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0007596; GO:0031012; GO:0042802; GO:1901346; GO:1903053
GN002343	GN002343.1	Q8SW43	29.1	172	783	190	4.85e-12	68.9	Z379_ENCCU	Zinc finger C2H2 protein ECU03_0790	Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)		DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634
GN002344	GN002344.1	Q9Y236	44.1	481	484	505	5.37e-131	392	OSGI2_HUMAN	Oxidative stress-induced growth inhibitor 2 (hT41)	Homo sapiens (Human)	negative regulation of cell growth [GO:0030308]	growth factor activity [GO:0008083]	midbody [GO:0030496]	GO:0008083; GO:0030308; GO:0030496
GN002345	GN002345.1	Q96RK4	43.6	436	585	519	7.95e-118	362	BBS4_HUMAN	BBSome complex member BBS4 (Bardet-Biedl syndrome 4 protein)	Homo sapiens (Human)	adult behavior [GO:0030534]; brain morphogenesis [GO:0048854]; centrosome cycle [GO:0007098]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; dendrite development [GO:0016358]; fat cell differentiation [GO:0045444]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; maintenance of protein location in nucleus [GO:0051457]; melanosome transport [GO:0032402]; microtubule anchoring at centrosome [GO:0034454]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; positive regulation of cilium assembly [GO:0045724]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of cytokinesis [GO:0032465]; regulation of lipid metabolic process [GO:0019216]; retina homeostasis [GO:0001895]; retinal rod cell development [GO:0046548]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893]; spermatid development [GO:0007286]; striatum development [GO:0021756]	alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; dynactin binding [GO:0034452]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	GO:0000226; GO:0000242; GO:0000281; GO:0001750; GO:0001843; GO:0001895; GO:0001917; GO:0001947; GO:0005634; GO:0005813; GO:0005814; GO:0005829; GO:0005929; GO:0007098; GO:0007286; GO:0007608; GO:0016358; GO:0019216; GO:0021756; GO:0021766; GO:0021987; GO:0030534; GO:0030674; GO:0031514; GO:0032391; GO:0032402; GO:0032465; GO:0034451; GO:0034452; GO:0034454; GO:0034464; GO:0035869; GO:0036064; GO:0038108; GO:0043014; GO:0045444; GO:0045494; GO:0045724; GO:0046548; GO:0048487; GO:0048854; GO:0050893; GO:0051457; GO:0060170; GO:0060271; GO:0060296; GO:0061512; GO:0061629; GO:0071539; GO:0097730; GO:1905515
GN002352	GN002352.1	Q92499	65.3	121	127	740	1.34e-47	165	DDX1_HUMAN	ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB)	Homo sapiens (Human)	double-strand break repair [GO:0006302]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of translational initiation [GO:0006446]; spliceosomal complex assembly [GO:0000245]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA/RNA helicase activity [GO:0033677]; double-stranded RNA binding [GO:0003725]; nuclease activity [GO:0004518]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coregulator activity [GO:0003712]	cleavage body [GO:0071920]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; tRNA-splicing ligase complex [GO:0072669]	GO:0000245; GO:0002735; GO:0003682; GO:0003712; GO:0003723; GO:0003724; GO:0003725; GO:0004518; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0006302; GO:0006388; GO:0006446; GO:0008143; GO:0010494; GO:0016020; GO:0016887; GO:0033677; GO:0043123; GO:0071920; GO:0072669; GO:1903608; GO:1990904
GN002357	GN002357.1	G3V9R8	56.2	73	126	298	3.76e-21	89.0	HNRPC_RAT	Heterogeneous nuclear ribonucleoprotein C (hnRNP C) (hnRNP core protein C)	Rattus norvegicus (Rat)	3'-UTR-mediated mRNA stabilization [GO:0070935]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA modification [GO:0090367]; negative regulation of telomere maintenance via telomerase [GO:0032211]	deaminase binding [GO:1990827]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; poly(U) RNA binding [GO:0008266]; protein domain specific binding [GO:0019904]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	actin cytoskeleton [GO:0015629]; catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleoplasmic periphery of the nuclear pore complex [GO:1990826]; nucleus [GO:0005634]; pronucleus [GO:0045120]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]	GO:0000398; GO:0003723; GO:0003729; GO:0003730; GO:0004857; GO:0005634; GO:0005654; GO:0005681; GO:0005697; GO:0005829; GO:0008266; GO:0015629; GO:0019904; GO:0032211; GO:0032991; GO:0042802; GO:0043021; GO:0045120; GO:0070034; GO:0070935; GO:0071013; GO:0090367; GO:1990247; GO:1990826; GO:1990827
GN002358	GN002358.1	Q5J8M3	53.7	177	174	183	4.53e-59	185	EMC4_HUMAN	ER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85)	Homo sapiens (Human)	protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]		EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0005789; GO:0016020; GO:0045050; GO:0071816; GO:0072546
GN002360	GN002360.1	Q924N4	50.8	1058	1101	1150	0.0	946	S12A6_MOUSE	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)	Mus musculus (Mouse)	cell volume homeostasis [GO:0006884]; cellular hypotonic response [GO:0071476]; cellular hypotonic salinity response [GO:0071477]; cellular response to glucose stimulus [GO:0071333]; chloride ion homeostasis [GO:0055064]; chloride transport [GO:0006821]; monoatomic ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]	potassium ion transmembrane transporter activity [GO:0015079]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005886; GO:0006811; GO:0006821; GO:0006884; GO:0015079; GO:0015379; GO:0016323; GO:0016324; GO:0019901; GO:0030424; GO:0055064; GO:0055075; GO:0071333; GO:0071476; GO:0071477; GO:0071805; GO:1990573
GN002364	GN002364.1	Q8C190	33.6	125	366	649	3.51e-13	74.3	VP9D1_MOUSE	VPS9 domain-containing protein 1 (5-day ovary-specific transcript 1 protein)	Mus musculus (Mouse)	vesicle-mediated transport [GO:0016192]	guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; endocytic vesicle [GO:0030139]	GO:0005085; GO:0005829; GO:0016192; GO:0030139; GO:0031267; GO:0042802
GN002365	GN002365.1	P24369	69.7	109	122	216	5.25e-51	163	PPIB_MOUSE	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	Mus musculus (Mouse)	bone development [GO:0060348]; host-mediated activation of viral genome replication [GO:0044829]; host-mediated activation of viral process [GO:0044794]; neutrophil chemotaxis [GO:0030593]; positive regulation of multicellular organism growth [GO:0040018]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase binding [GO:0070063]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; smooth endoplasmic reticulum [GO:0005790]	GO:0003755; GO:0005654; GO:0005783; GO:0005788; GO:0005790; GO:0006457; GO:0016018; GO:0030593; GO:0032991; GO:0034663; GO:0040018; GO:0042470; GO:0044794; GO:0044829; GO:0048471; GO:0050821; GO:0060348; GO:0070063
GN002366	GN002366.1	P24367	55.1	187	224	207	3.43e-62	196	PPIB_CHICK	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	Gallus gallus (Chicken)	negative regulation of collagen fibril organization [GO:1904027]; protein folding [GO:0006457]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]; protein-containing complex [GO:0032991]	GO:0003755; GO:0005788; GO:0006457; GO:0016018; GO:0032991; GO:0042470; GO:1904027
GN002370	GN002370.1	Q68ED3	61.7	332	390	633	1.36e-127	384	PAPD5_MOUSE	Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2)	Mus musculus (Mouse)	carbohydrate homeostasis [GO:0033500]; histone mRNA catabolic process [GO:0071044]; miRNA catabolic process [GO:0010587]; mRNA 3'-end processing [GO:0031124]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; negative regulation of telomere maintenance via telomerase [GO:0032211]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; polyadenylation-dependent ncRNA catabolic process [GO:0043634]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; RNA 3'-end processing [GO:0031123]	guanylyltransferase activity [GO:0070568]; poly(A) RNA polymerase activity [GO:1990817]; telomerase RNA binding [GO:0070034]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; TRAMP complex [GO:0031499]	GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0010587; GO:0031123; GO:0031124; GO:0031499; GO:0032211; GO:0033500; GO:0043634; GO:0060212; GO:0070034; GO:0070568; GO:0071044; GO:0071051; GO:1905870; GO:1990817
GN002371	GN002371.1	O43313	33.9	186	797	823	4.95e-18	92.8	ATMIN_HUMAN	ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ) (Zinc finger protein 822)	Homo sapiens (Human)	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; dynein complex binding [GO:0070840]; transcription cis-regulatory region binding [GO:0000976]	nuclear body [GO:0016604]; nucleus [GO:0005634]	GO:0000976; GO:0000981; GO:0001228; GO:0005634; GO:0006357; GO:0016604; GO:0045893; GO:0045944; GO:0070840
GN002374	GN002374.1	H2A0L1	35.7	440	710	456	1.00e-60	214	TYRO2_PINMG	Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2)	Margaritifera margaritifera (Freshwater pearl mussel)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN002375	GN002375.1	O60290	24.8	456	476	1169	2.43e-32	134	ZN862_HUMAN	Zinc finger protein 862	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	protein dimerization activity [GO:0046983]	nucleus [GO:0005634]	GO:0005634; GO:0006355; GO:0046983
GN002376	GN002376.1	O60290	40.6	64	108	1169	4.04e-12	64.3	ZN862_HUMAN	Zinc finger protein 862	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	protein dimerization activity [GO:0046983]	nucleus [GO:0005634]	GO:0005634; GO:0006355; GO:0046983
GN002377	GN002377.1	P54269	62.7	201	466	693	3.37e-65	225	CAUP_DROME	Homeobox protein caupolican	Drosophila melanogaster (Fruit fly)	cell development [GO:0048468]; compound eye morphogenesis [GO:0001745]; equator specification [GO:0045317]; imaginal disc-derived wing vein specification [GO:0007474]; muscle cell fate commitment [GO:0042693]; negative regulation of growth [GO:0045926]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001745; GO:0003700; GO:0005634; GO:0006357; GO:0007346; GO:0007474; GO:0030182; GO:0042693; GO:0045317; GO:0045926; GO:0045944; GO:0048468
GN002379	GN002379.1	Q02391	45.1	508	601	1142	5.88e-151	467	GSLG1_CHICK	Golgi apparatus protein 1 (Cysteine-rich fibroblast growth factor receptor)	Gallus gallus (Chicken)			extracellular matrix [GO:0031012]; Golgi membrane [GO:0000139]; microtubule organizing center [GO:0005815]; postsynaptic Golgi apparatus [GO:0150051]	GO:0000139; GO:0005815; GO:0031012; GO:0150051
GN002380	GN002380.1	Q61543	42.3	513	511	1175	6.18e-127	401	GSLG1_MOUSE	Golgi apparatus protein 1 (E-selectin ligand 1) (ESL-1) (Selel) (Golgi sialoglycoprotein MG-160)	Mus musculus (Mouse)	bone morphogenesis [GO:0060349]; negative regulation of protein processing [GO:0010955]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of chondrocyte differentiation [GO:0032330]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	fibroblast growth factor binding [GO:0017134]	extracellular matrix [GO:0031012]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; postsynaptic Golgi apparatus [GO:0150051]; sperm end piece [GO:0097229]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0000139; GO:0005794; GO:0005797; GO:0005815; GO:0005886; GO:0010955; GO:0017015; GO:0017134; GO:0030512; GO:0031012; GO:0032330; GO:0060349; GO:0097225; GO:0097228; GO:0097229; GO:0150051
GN002386	GN002386.1	Q02391	46.3	188	190	1142	1.29e-51	181	GSLG1_CHICK	Golgi apparatus protein 1 (Cysteine-rich fibroblast growth factor receptor)	Gallus gallus (Chicken)			extracellular matrix [GO:0031012]; Golgi membrane [GO:0000139]; microtubule organizing center [GO:0005815]; postsynaptic Golgi apparatus [GO:0150051]	GO:0000139; GO:0005815; GO:0031012; GO:0150051
GN002387	GN002387.1	Q8XIY6	34.0	97	320	214	3.93e-11	65.1	PPAX_CLOPE	Putative pyrophosphatase PpaX (EC 3.6.1.1)	Clostridium perfringens (strain 13 / Type A)	DNA repair [GO:0006281]	inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]; phosphoglycolate phosphatase activity [GO:0008967]	cytosol [GO:0005829]	GO:0000287; GO:0004427; GO:0005829; GO:0006281; GO:0008967
GN002388	GN002388.1	Q8BJ64	65.2	563	816	596	1.26e-269	761	CHDH_MOUSE	Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)	Mus musculus (Mouse)	glycine betaine biosynthetic process from choline [GO:0019285]	choline dehydrogenase activity [GO:0008812]; flavin adenine dinucleotide binding [GO:0050660]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0005739; GO:0005741; GO:0005743; GO:0008812; GO:0019285; GO:0050660
GN002390	GN002390.1	Q6TLE6	54.3	129	129	222	3.91e-41	139	CRCM1_DANRE	Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A)	Danio rerio (Zebrafish) (Brachydanio rerio)	positive regulation of calcium ion transport [GO:0051928]; sarcomere organization [GO:0045214]; store-operated calcium entry [GO:0002115]	store-operated calcium channel activity [GO:0015279]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0002115; GO:0005886; GO:0015279; GO:0016020; GO:0045214; GO:0051928
GN002391	GN002391.1	Q8NHM5	37.5	1345	1290	1336	6.55e-247	746	KDM2B_HUMAN	Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; embryonic camera-type eye morphogenesis [GO:0048596]; forebrain development [GO:0030900]; fourth ventricle development [GO:0021592]; heterochromatin formation [GO:0031507]; hindbrain development [GO:0030902]; initiation of neural tube closure [GO:0021993]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; spermatogenesis [GO:0007283]; third ventricle development [GO:0021678]	DNA binding [GO:0003677]; histone demethylase activity [GO:0032452]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coregulator activity [GO:0003712]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; SCF ubiquitin ligase complex [GO:0019005]	GO:0000122; GO:0000785; GO:0000978; GO:0003677; GO:0003712; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0006338; GO:0006357; GO:0007283; GO:0008270; GO:0019005; GO:0021555; GO:0021592; GO:0021670; GO:0021678; GO:0021993; GO:0030900; GO:0030901; GO:0030902; GO:0031146; GO:0031507; GO:0031519; GO:0032452; GO:0035102; GO:0043524; GO:0045322; GO:0045892; GO:0048596; GO:0051864; GO:0140680; GO:2000178
GN002392	GN002392.1	P49951	35.5	265	331	1675	1.85e-52	189	CLH1_BOVIN	Clathrin heavy chain 1	Bos taurus (Bovine)	clathrin coat assembly [GO:0048268]; clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; negative regulation of hyaluronan biosynthetic process [GO:1900126]	arrestin family protein binding [GO:1990763]; clathrin light chain binding [GO:0032051]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; structural molecule activity [GO:0005198]	clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle [GO:0045334]; melanosome [GO:0042470]; membrane coat [GO:0030117]; mitochondrion [GO:0005739]; spindle [GO:0005819]	GO:0000278; GO:0005198; GO:0005739; GO:0005819; GO:0006886; GO:0019904; GO:0030117; GO:0030130; GO:0030132; GO:0032051; GO:0042470; GO:0042802; GO:0045334; GO:0048268; GO:0071439; GO:0072318; GO:0072583; GO:0097718; GO:1900126; GO:1990763
GN002393	GN002393.1	Q58CS6	77.3	132	132	156	2.29e-61	188	IFT20_BOVIN	Intraflagellar transport protein 20 homolog	Bos taurus (Bovine)	cilium assembly [GO:0060271]; positive regulation of cilium assembly [GO:0045724]; protein localization to ciliary membrane [GO:1903441]; protein localization to cilium [GO:0061512]; regulation of autophagosome assembly [GO:2000785]; regulation of cilium assembly [GO:1902017]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; spermatogenesis [GO:0007283]	opsin binding [GO:0002046]; small GTPase binding [GO:0031267]	acrosomal vesicle [GO:0001669]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cilium [GO:0005929]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; dendrite terminus [GO:0044292]; Golgi apparatus [GO:0005794]; intraciliary transport particle [GO:0030990]; intraciliary transport particle A [GO:0030991]; intraciliary transport particle B [GO:0030992]; kinociliary basal body [GO:1902636]; manchette [GO:0002177]; microvillus [GO:0005902]; motile cilium [GO:0031514]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; stereocilium [GO:0032420]	GO:0001669; GO:0001750; GO:0002046; GO:0002177; GO:0005737; GO:0005794; GO:0005801; GO:0005813; GO:0005814; GO:0005902; GO:0005929; GO:0007283; GO:0030990; GO:0030991; GO:0030992; GO:0031267; GO:0031514; GO:0032391; GO:0032420; GO:0036064; GO:0043005; GO:0044292; GO:0045724; GO:0060271; GO:0061512; GO:0097546; GO:0097730; GO:1902017; GO:1902636; GO:1903441; GO:2000583; GO:2000785
GN002394	GN002394.1	Q7TPL3	70.3	276	287	315	3.79e-132	380	BACD3_RAT	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (BTB/POZ domain-containing protein KCTD10)	Rattus norvegicus (Rat)	angiogenesis [GO:0001525]; cilium assembly [GO:0060271]; establishment of endothelial barrier [GO:0061028]; heart development [GO:0007507]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of cilium assembly [GO:0045724]; positive regulation of ferroptosis [GO:0160020]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	identical protein binding [GO:0042802]; Notch binding [GO:0005112]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; MKS complex [GO:0036038]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001525; GO:0005112; GO:0005634; GO:0005654; GO:0005737; GO:0006511; GO:0007507; GO:0016567; GO:0031463; GO:0035024; GO:0036038; GO:0042802; GO:0043161; GO:0045724; GO:0045746; GO:0051260; GO:0060271; GO:0061028; GO:0160020; GO:1902523; GO:1990756
GN002399	GN002399.1	G5E8Z2	34.4	724	933	850	1.78e-68	248	TAF4B_MOUSE	Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105)	Mus musculus (Mouse)	mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	DNA binding [GO:0003677]; NF-kappaB binding [GO:0051059]; protein heterodimerization activity [GO:0046982]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription regulator complex [GO:0005667]	GO:0001650; GO:0003677; GO:0005634; GO:0005654; GO:0005667; GO:0005669; GO:0005737; GO:0006357; GO:0006366; GO:0006367; GO:0042789; GO:0046982; GO:0051059; GO:0051123; GO:0060261; GO:2000648
GN002402	GN002402.1	Q6ZNF0	39.1	458	593	438	9.17e-91	290	ACP7_HUMAN	Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form)	Homo sapiens (Human)		acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872]	extracellular region [GO:0005576]	GO:0003993; GO:0005576; GO:0046872
GN002403	GN002403.1	Q19AE6	32.3	294	411	627	2.51e-42	160	ACHA4_MUSPF	Neuronal acetylcholine receptor subunit alpha-4	Mustela putorius furo (European domestic ferret) (Mustela furo)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; cognition [GO:0050890]; DNA repair [GO:0006281]; nervous system process [GO:0050877]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]	GO:0001666; GO:0005886; GO:0005892; GO:0006281; GO:0006979; GO:0007165; GO:0007271; GO:0015464; GO:0022848; GO:0035095; GO:0042734; GO:0045211; GO:0050877; GO:0050890; GO:0095500; GO:0097060
GN002405	GN002405.1	Q90YV5	70.6	211	212	211	1.15e-94	278	RL13_ICTPU	Large ribosomal subunit protein eL13 (60S ribosomal protein L13)	Ictalurus punctatus (Channel catfish) (Silurus punctatus)	translation [GO:0006412]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]	GO:0003723; GO:0003735; GO:0005737; GO:0006412; GO:0022625
GN002406	GN002406.1	A0JPN4	47.9	219	901	596	3.07e-58	213	ZC12A_RAT	Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A)	Rattus norvegicus (Rat)	3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to chemokine [GO:1990869]; cellular response to glucose starvation [GO:0042149]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; cellular response to sodium arsenite [GO:1903936]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; DNA damage response [GO:0006974]; host-mediated suppression of viral genome replication [GO:0044828]; immune response-activating signaling pathway [GO:0002757]; miRNA catabolic process [GO:0010587]; mRNA catabolic process [GO:0006402]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage activation [GO:0043031]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein complex oligomerization [GO:0051259]; protein deubiquitination [GO:0016579]; regulation of gene expression [GO:0010468]; T cell receptor signaling pathway [GO:0050852]	chromatin binding [GO:0003682]; cysteine-type deubiquitinase activity [GO:0004843]; DNA binding [GO:0003677]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; nuclease activity [GO:0004518]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA exonuclease activity [GO:0004532]; RNA nuclease activity [GO:0004540]; RNA stem-loop binding [GO:0035613]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; rough endoplasmic reticulum [GO:0005791]; rough endoplasmic reticulum membrane [GO:0030867]	GO:0000122; GO:0000932; GO:0001933; GO:0002230; GO:0002757; GO:0003677; GO:0003682; GO:0003723; GO:0003729; GO:0003730; GO:0004518; GO:0004521; GO:0004532; GO:0004540; GO:0004843; GO:0005634; GO:0005654; GO:0005737; GO:0005791; GO:0005856; GO:0006402; GO:0006974; GO:0008270; GO:0010468; GO:0010508; GO:0010587; GO:0010595; GO:0010628; GO:0010629; GO:0010656; GO:0010884; GO:0016579; GO:0030867; GO:0032689; GO:0032691; GO:0032715; GO:0032720; GO:0032991; GO:0034599; GO:0035198; GO:0035613; GO:0035925; GO:0036464; GO:0042149; GO:0042307; GO:0043022; GO:0043031; GO:0043124; GO:0044828; GO:0045019; GO:0045600; GO:0045766; GO:0045944; GO:0050852; GO:0051259; GO:0055118; GO:0061014; GO:0061158; GO:0071222; GO:0071356; GO:0098586; GO:1900016; GO:1900119; GO:1900745; GO:1901223; GO:1903003; GO:1903936; GO:1904637; GO:1990869; GO:2000320; GO:2000379; GO:2000627
GN002407	GN002407.1	Q8BJ64	65.2	563	816	596	6.29e-270	762	CHDH_MOUSE	Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)	Mus musculus (Mouse)	glycine betaine biosynthetic process from choline [GO:0019285]	choline dehydrogenase activity [GO:0008812]; flavin adenine dinucleotide binding [GO:0050660]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0005739; GO:0005741; GO:0005743; GO:0008812; GO:0019285; GO:0050660
GN002408	GN002408.1	Q8XIY6	34.0	97	284	214	2.77e-11	65.1	PPAX_CLOPE	Putative pyrophosphatase PpaX (EC 3.6.1.1)	Clostridium perfringens (strain 13 / Type A)	DNA repair [GO:0006281]	inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]; phosphoglycolate phosphatase activity [GO:0008967]	cytosol [GO:0005829]	GO:0000287; GO:0004427; GO:0005829; GO:0006281; GO:0008967
GN002409	GN002409.1	Q95NT6	23.9	205	259	536	8.31e-12	68.2	MTH2_DROYA	G protein-coupled receptor Mth2 (Protein methuselah-2)	Drosophila yakuba (Fruit fly)	cell surface receptor signaling pathway [GO:0007166]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007166; GO:0008528
GN002411	GN002411.1	P50093	53.7	54	68	294	4.16e-12	62.0	PHB2_CAEEL	Mitochondrial prohibitin complex protein 2 (Prohibitin-2)	Caenorhabditis elegans	defecation [GO:0030421]; embryo development ending in birth or egg hatching [GO:0009792]; gonad development [GO:0008406]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; oogenesis [GO:0048477]; positive regulation of multicellular organism growth [GO:0040018]; protein stabilization [GO:0050821]; regulation of nematode pharyngeal pumping [GO:0043051]; regulation of oxidative phosphorylation [GO:0002082]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283]	protein homodimerization activity [GO:0042803]	cell surface [GO:0009986]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial prohibitin complex [GO:0035632]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0000423; GO:0002082; GO:0005739; GO:0005743; GO:0005886; GO:0006979; GO:0007005; GO:0007283; GO:0008406; GO:0009792; GO:0009986; GO:0030421; GO:0031966; GO:0035632; GO:0040018; GO:0042803; GO:0043051; GO:0048477; GO:0050821
GN002412	GN002412.1	Q99623	79.0	138	159	299	6.68e-65	203	PHB2_HUMAN	Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; B cell activation [GO:0042113]; cell migration [GO:0016477]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of cardiolipin metabolic process [GO:1900208]; regulation of transcription by RNA polymerase II [GO:0006357]; RIG-I signaling pathway [GO:0039529]; sister chromatid cohesion [GO:0007062]	binding [GO:0005488]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; sphingolipid binding [GO:0046625]	cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial prohibitin complex [GO:0035632]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GO:0000423; GO:0002639; GO:0005488; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005886; GO:0006357; GO:0006606; GO:0007005; GO:0007062; GO:0009986; GO:0016363; GO:0016477; GO:0030331; GO:0032991; GO:0035632; GO:0039529; GO:0042113; GO:0042802; GO:0042803; GO:0043066; GO:0045892; GO:0046625; GO:0046982; GO:0050821; GO:0070374; GO:0071944; GO:0140374; GO:1900208; GO:1901224
GN002415	GN002415.1	Q9Y6H1	69.2	104	148	151	3.81e-20	84.0	CHCH2_HUMAN	Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP)	Homo sapiens (Human)	cellular response to oxidative stress [GO:0034599]; mitochondrion organization [GO:0007005]; positive regulation of mitochondrial ATP synthesis coupled electron transport [GO:1905448]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cellular response to hypoxia [GO:1900037]; regulation of generation of precursor metabolites and energy [GO:0043467]	DNA-binding transcription factor binding [GO:0140297]; sequence-specific DNA binding [GO:0043565]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005739; GO:0005758; GO:0007005; GO:0034599; GO:0043467; GO:0043565; GO:0045944; GO:0140297; GO:1900037; GO:1905448
GN002419	GN002419.1	Q5F371	71.7	152	164	1239	5.40e-70	232	SBNO1_CHICK	Protein strawberry notch homolog 1	Gallus gallus (Chicken)	negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of neuroinflammatory response [GO:0150079]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neural precursor cell proliferation [GO:2000179]; regulation of DNA-templated transcription [GO:0006355]		nucleus [GO:0005634]	GO:0005634; GO:0006355; GO:0043124; GO:0043409; GO:0090263; GO:0150079; GO:2000179
GN002421	GN002421.1	Q6IDD9	55.7	628	904	1360	8.30e-221	666	SARM1_DROME	NAD(+) hydrolase sarm1 (NADase sarm1) (EC 3.2.2.6) (Sterile alpha and TIR motif-containing protein 1) (Tir-1 homolog)	Drosophila melanogaster (Fruit fly)	antiviral innate immune response [GO:0140374]; defense response to virus [GO:0051607]; NAD+ catabolic process [GO:0019677]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; response to axon injury [GO:0048678]; signal transduction [GO:0007165]	NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleosidase activity, cyclic ADP-ribose generating [GO:0061809]; signaling adaptor activity [GO:0035591]; STAT family protein binding [GO:0097677]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]	GO:0003953; GO:0005737; GO:0005739; GO:0005829; GO:0007165; GO:0019677; GO:0030424; GO:0030425; GO:0035591; GO:0043005; GO:0043025; GO:0048678; GO:0051607; GO:0061809; GO:0097677; GO:0140374; GO:1904894
GN002424	GN002424.1	Q8BJ25	37.9	95	106	218	8.60e-13	64.7	THAP3_MOUSE	THAP domain-containing protein 3	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]			GO:0045944
GN002425	GN002425.1	Q9BXJ5	29.4	136	389	285	4.96e-09	60.5	C1QT2_HUMAN	Complement C1q tumor necrosis factor-related protein 2	Homo sapiens (Human)	regulation of lipid metabolic process [GO:0019216]	identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; protein-containing complex [GO:0032991]	GO:0005102; GO:0005576; GO:0019216; GO:0032991; GO:0042802
GN002426	GN002426.1	Q9NZF1	35.2	88	141	115	2.66e-09	54.7	PLAC8_HUMAN	Placenta-specific gene 8 protein (Protein C15)	Homo sapiens (Human)	positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription by RNA polymerase II [GO:0045944]	chromatin binding [GO:0003682]	azurophil granule lumen [GO:0035578]; extracellular region [GO:0005576]	GO:0003682; GO:0005576; GO:0035578; GO:0045944; GO:0120162
GN002433	GN002433.1	Q6ZUK4	39.4	180	330	368	2.03e-23	102	TMM26_HUMAN	Transmembrane protein 26	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN002436	GN002436.1	Q86V15	27.3	1412	1263	1759	8.61e-129	439	CASZ1_HUMAN	Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693)	Homo sapiens (Human)	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron differentiation [GO:0045664]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000977; GO:0000981; GO:0001228; GO:0005634; GO:0005654; GO:0045664; GO:0045893; GO:0045944
GN002437	GN002437.1	G5EFC3	38.6	184	317	558	4.12e-32	128	KCNAG_CAEEL	Potassium voltage-gated channel protein egl-36 (Egg-laying defective protein 36)	Caenorhabditis elegans	action potential [GO:0001508]; monoatomic ion transmembrane transport [GO:0034220]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic ion channel activity [GO:0005244]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005244; GO:0005251; GO:0008076; GO:0016020; GO:0032590; GO:0032809; GO:0034220; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN002439	GN002439.1	O13016	55.1	263	404	434	3.20e-98	302	PTN1_CHICK	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (CPTP1) (Protein-tyrosine phosphatase 1B) (PTP-1B)	Gallus gallus (Chicken)	actin cytoskeleton organization [GO:0030036]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of endocytosis [GO:0030100]; regulation of signal transduction [GO:0009966]	non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0004725; GO:0004726; GO:0005737; GO:0005769; GO:0005783; GO:0005789; GO:0009966; GO:0019901; GO:0030036; GO:0030100; GO:0030968; GO:0035335; GO:0070373; GO:1903898
GN002444	GN002444.1	Q8VE96	53.6	192	208	372	1.40e-55	183	S35F6_MOUSE	Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog)	Mus musculus (Mouse)	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation of cell population proliferation [GO:0008284]	transmembrane transporter activity [GO:0022857]	cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005739; GO:0005764; GO:0005765; GO:0005829; GO:0008284; GO:0016020; GO:0022857; GO:1901029
GN002446	GN002446.1	D3YZI9	32.2	121	251	523	6.73e-09	59.3	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN002452	GN002452.1	Q8BTI8	54.2	179	507	2703	7.66e-47	179	SRRM2_MOUSE	Serine/arginine repetitive matrix protein 2	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]	C2H2 zinc finger domain binding [GO:0070742]; mRNA binding [GO:0003729]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; post-spliceosomal complex [GO:0071020]; spliceosomal complex [GO:0005681]; U12-type catalytic step 2 spliceosome [GO:0071018]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]	GO:0000398; GO:0003729; GO:0005634; GO:0005681; GO:0015030; GO:0016607; GO:0070742; GO:0071005; GO:0071006; GO:0071007; GO:0071013; GO:0071018; GO:0071020
GN002454	GN002454.1	O97788	34.9	129	131	132	2.72e-20	83.2	FABP4_PIG	Fatty acid-binding protein, adipocyte (AP2) (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)	Sus scrofa (Pig)	fatty acid transport [GO:0015908]; long-chain fatty acid transport [GO:0015909]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of fat cell proliferation [GO:0070346]; triglyceride catabolic process [GO:0019433]	fatty acid binding [GO:0005504]; hormone receptor binding [GO:0051427]; lipase activator activity [GO:0060229]; long-chain fatty acid binding [GO:0036041]; long-chain fatty acid transmembrane transporter activity [GO:0005324]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; nucleus [GO:0005634]	GO:0005324; GO:0005504; GO:0005634; GO:0005737; GO:0005811; GO:0005829; GO:0015908; GO:0015909; GO:0019433; GO:0036041; GO:0051427; GO:0060229; GO:0070346; GO:0120162
GN002455	GN002455.1	Q6GPJ4	22.8	316	597	419	1.37e-16	85.9	MRM3_XENLA	rRNA methyltransferase 3, mitochondrial (EC 2.1.1.-) (RNA methyltransferase-like protein 1) (rRNA (guanosine-2'-O)-methyltransferase)	Xenopus laevis (African clawed frog)	RNA processing [GO:0006396]	RNA binding [GO:0003723]; rRNA (uridine-2'-O-ribose)-methyltransferase activity [GO:0008650]	mitochondrion [GO:0005739]	GO:0003723; GO:0005739; GO:0006396; GO:0008650
GN002456	GN002456.1	P17972	35.6	222	350	498	6.08e-30	122	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN002464	GN002464.1	P71359	31.1	132	150	619	4.45e-10	60.1	RECQ_HAEIN	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]	GO:0003676; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0009432; GO:0016887; GO:0030894; GO:0043138; GO:0043590
GN002476	GN002476.1	Q8N328	27.2	250	249	593	2.17e-15	78.6	PGBD3_HUMAN	PiggyBac transposable element-derived protein 3	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0005634; GO:0043565
GN002478	GN002478.1	Q8N328	27.2	250	249	593	2.94e-15	78.2	PGBD3_HUMAN	PiggyBac transposable element-derived protein 3	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0005634; GO:0043565
GN002485	GN002485.1	Q96MB7	40.3	129	162	349	4.39e-21	90.9	HARB1_HUMAN	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Homo sapiens (Human)			cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005829; GO:0005886
GN002486	GN002486.1	Q8IVF4	68.9	1577	1586	4471	0.0	2213	DYH10_HUMAN	Dynein axonemal heavy chain 10 (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10)	Homo sapiens (Human)	cilium movement involved in cell motility [GO:0060294]	ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule binding [GO:0008017]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; dynein complex [GO:0030286]; sperm principal piece [GO:0097228]	GO:0005524; GO:0005858; GO:0008017; GO:0008569; GO:0030286; GO:0045505; GO:0051959; GO:0060294; GO:0097228; GO:0097729
GN002495	GN002495.1	Q68DL7	31.2	314	719	685	1.41e-43	171	CR063_HUMAN	Uncharacterized protein C18orf63	Homo sapiens (Human)	male gonad development [GO:0008584]			GO:0008584
GN002496	GN002496.1	Q28727	31.0	313	418	347	2.09e-41	152	NTCP2_RABIT	Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2)	Oryctolagus cuniculus (Rabbit)		bile acid:sodium symporter activity [GO:0008508]	apical plasma membrane [GO:0016324]	GO:0008508; GO:0016324
GN002498	GN002498.1	Q5TF39	30.2	388	467	518	1.18e-44	166	S60A2_HUMAN	Solute carrier family 60 member 2 (Major facilitator superfamily domain-containing protein 4B) (Sodium-dependent glucose transporter 1)	Homo sapiens (Human)	D-glucose import across plasma membrane [GO:0098708]	D-glucose:sodium symporter activity [GO:0005412]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]	GO:0005412; GO:0016324; GO:0031526; GO:0098708
GN002506	GN002506.1	Q9CWG1	29.8	121	261	255	1.87e-11	65.9	GLIP1_MOUSE	Glioma pathogenesis-related protein 1 (GliPR 1)	Mus musculus (Mouse)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN002508	GN002508.1	Q5ZMH1	71.8	355	398	349	2.08e-180	508	SEPT2_CHICK	Septin-2	Gallus gallus (Chicken)	cilium assembly [GO:0060271]; cytoskeleton-dependent cytokinesis [GO:0061640]; intracellular protein localization [GO:0008104]; regulation of exocytosis [GO:0017157]; smoothened signaling pathway [GO:0007224]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]	cell division site [GO:0032153]; ciliary membrane [GO:0060170]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; septin complex [GO:0031105]; septin ring [GO:0005940]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]	GO:0003924; GO:0005525; GO:0005737; GO:0005819; GO:0005940; GO:0007224; GO:0008021; GO:0008104; GO:0015630; GO:0017157; GO:0030496; GO:0031105; GO:0032153; GO:0032154; GO:0060090; GO:0060170; GO:0060271; GO:0061640
GN002509	GN002509.1	Q5R6R7	61.9	360	514	478	7.64e-151	442	SEPT4_PONAB	Septin-4	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	flagellated sperm motility [GO:0030317]; hematopoietic stem cell homeostasis [GO:0061484]; neuron migration [GO:0001764]; spermatid differentiation [GO:0048515]	GTP binding [GO:0005525]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; perikaryon [GO:0043204]; septin complex [GO:0031105]; sperm annulus [GO:0097227]; synapse [GO:0045202]; transport vesicle [GO:0030133]	GO:0001764; GO:0005525; GO:0005737; GO:0030133; GO:0030317; GO:0030424; GO:0030425; GO:0031105; GO:0043204; GO:0045202; GO:0048515; GO:0061484; GO:0097227
GN002511	GN002511.1	P49109	51.6	395	474	533	1.77e-144	427	FMO5_CAVPO	Flavin-containing monooxygenase 5 (FMO 5) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (NADPH oxidase) (EC 1.6.3.1)	Cavia porcellus (Guinea pig)	regulation of cholesterol metabolic process [GO:0090181]; xenobiotic metabolic process [GO:0006805]	flavin adenine dinucleotide binding [GO:0050660]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADP binding [GO:0050661]	endoplasmic reticulum membrane [GO:0005789]	GO:0004497; GO:0004499; GO:0005789; GO:0006805; GO:0016174; GO:0050660; GO:0050661; GO:0090181
GN002515	GN002515.1	Q9VBP3	24.9	241	471	1181	2.78e-10	66.6	TNKS_DROME	Poly [ADP-ribose] polymerase tankyrase (dTNKS) (EC 2.4.2.30) (Poly [ADP-ribose] polymerase) (Protein poly-ADP-ribosyltransferase tankyrase) (EC 2.4.2.-)	Drosophila melanogaster (Fruit fly)	positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of telomere capping [GO:1904355]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein localization to chromosome, telomeric region [GO:0070198]	NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003950; GO:0005634; GO:0005737; GO:0005829; GO:0032436; GO:0045732; GO:0046330; GO:0070198; GO:0090263; GO:0140806; GO:0140807; GO:1904355; GO:2000060
GN002518	GN002518.1	Q8MJY8	46.0	139	171	266	1.31e-31	117	PGDH_MACFA	15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Eicosanoid/docosanoid dehydrogenase [NAD(+)]) (EC 1.1.1.-, EC 1.1.1.232) (Prostaglandin dehydrogenase 1)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; lipoxin biosynthetic process [GO:2001301]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin catabolic process [GO:1905344]; prostaglandin metabolic process [GO:0006693]; regulation of prostaglandin catabolic process [GO:1905828]; thrombin-activated receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179]	15-hydroxyicosatetraenoate dehydrogenase activity [GO:0047034]; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity [GO:0016404]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E receptor activity [GO:0004957]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004957; GO:0005737; GO:0005829; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016323; GO:0016404; GO:0016616; GO:0030728; GO:0042802; GO:0045786; GO:0047034; GO:0051287; GO:0070403; GO:0070493; GO:0097070; GO:1905344; GO:1905828; GO:2001301
GN002520	GN002520.1	A2VE54	33.2	464	654	457	4.69e-69	235	UN93A_BOVIN	N-acetylglucosamine transporter UNC93A (Protein unc-93 homolog A) (Unc-93A)	Bos taurus (Bovine)		N-acetylglucosamine transmembrane transporter activity [GO:0015572]	plasma membrane [GO:0005886]	GO:0005886; GO:0015572
GN002522	GN002522.1	Q9W707	85.7	126	395	372	1.97e-71	231	FXF1B_XENLA	Forkhead box protein F1-B (FoxF1-B) (FoxF1b) (Fork head domain-related protein 13') (xFD-13')	Xenopus laevis (African clawed frog)	animal organ morphogenesis [GO:0009887]; BMP signaling pathway [GO:0030509]; embryonic digestive tract development [GO:0048566]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; smooth muscle tissue development [GO:0048745]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0006357; GO:0009887; GO:0030509; GO:0045893; GO:0048566; GO:0048745
GN002524	GN002524.1	Q2YDM5	62.8	43	75	216	2.93e-11	59.3	SMIP8_BOVIN	Sperm microtubule inner protein 8 (Testis, prostate and placenta-expressed protein)	Bos taurus (Bovine)	flagellated sperm motility [GO:0030317]		axonemal A tubule inner sheath [GO:0160111]; sperm flagellum [GO:0036126]	GO:0030317; GO:0036126; GO:0160111
GN002525	GN002525.1	Q9Y4E6	45.7	1576	1497	1490	0.0	1198	WDR7_HUMAN	WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG)	Homo sapiens (Human)	vacuolar acidification [GO:0007035]		cytoplasm [GO:0005737]; RAVE complex [GO:0043291]	GO:0005737; GO:0007035; GO:0043291
GN002527	GN002527.1	Q8NDN9	60.9	530	531	531	1.27e-248	694	RCBT1_HUMAN	RCC1 and BTB domain-containing protein 1 (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein) (Regulator of chromosome condensation and BTB domain-containing protein 1)	Homo sapiens (Human)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN002531	GN002531.1	Q13884	46.8	526	490	538	5.18e-152	447	SNTB1_HUMAN	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43)	Homo sapiens (Human)	camera-type eye development [GO:0043010]; muscle contraction [GO:0006936]	PDZ domain binding [GO:0030165]; structural molecule activity [GO:0005198]	cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202]	GO:0005198; GO:0005856; GO:0005886; GO:0005925; GO:0006936; GO:0016010; GO:0030165; GO:0031594; GO:0032991; GO:0042383; GO:0043010; GO:0045202
GN002532	GN002532.1	Q32LE4	42.6	162	184	188	4.57e-37	129	GGCT_BOVIN	Gamma-glutamylcyclotransferase (EC 4.3.2.9)	Bos taurus (Bovine)	release of cytochrome c from mitochondria [GO:0001836]	gamma-glutamylcyclotransferase activity [GO:0003839]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]	GO:0001836; GO:0003839; GO:0005829; GO:0042803
GN002533	GN002533.1	Q4R930	64.4	146	182	163	5.63e-60	187	AR2BP_MACFA	ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	maintenance of protein location in nucleus [GO:0051457]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]	transcription coactivator activity [GO:0003713]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; midbody [GO:0030496]; mitochondrial intermembrane space [GO:0005758]; nucleoplasm [GO:0005654]; spindle [GO:0005819]	GO:0003713; GO:0005654; GO:0005758; GO:0005813; GO:0005819; GO:0030496; GO:0036064; GO:0042531; GO:0051457
GN002538	GN002538.1	Q6DDT1	70.4	504	538	563	1.03e-252	706	INO1B_XENLA	Inositol-3-phosphate synthase 1-B (IPS 1-B) (EC 5.5.1.4) (Myo-inositol 1-phosphate synthase B) (MI-1-P synthase B) (MIP synthase B)	Xenopus laevis (African clawed frog)	inositol biosynthetic process [GO:0006021]; phospholipid biosynthetic process [GO:0008654]	inositol-3-phosphate synthase activity [GO:0004512]	cytoplasm [GO:0005737]	GO:0004512; GO:0005737; GO:0006021; GO:0008654
GN002541	GN002541.1	Q8CJF7	35.1	793	2208	2243	4.69e-127	451	ELYS_MOUSE	Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1)	Mus musculus (Mouse)	hemopoiesis [GO:0030097]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; regulation of cytokinesis [GO:0032465]		chromatin [GO:0000785]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000776; GO:0000785; GO:0005634; GO:0005635; GO:0005643; GO:0005654; GO:0005737; GO:0006913; GO:0016363; GO:0016604; GO:0030097; GO:0031080; GO:0031965; GO:0032465; GO:0051292
GN002542	GN002542.1	Q86VM9	43.3	194	1383	953	9.07e-31	135	ZCH18_HUMAN	Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1)	Homo sapiens (Human)	RNA destabilization [GO:0050779]	metal ion binding [GO:0046872]; mRNA cap binding complex binding [GO:0140262]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005654; GO:0016607; GO:0030674; GO:0032991; GO:0046872; GO:0050779; GO:0140262; GO:1990904
GN002544	GN002544.1	O62703	66.7	396	395	563	1.11e-182	522	CTBL1_BOVIN	Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (p14)	Bos taurus (Bovine)	gene expression [GO:0010467]		nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]	GO:0000974; GO:0005634; GO:0005681; GO:0010467
GN002545	GN002545.1	P0C6T1	51.2	125	125	121	8.96e-38	127	CTF8_RAT	Chromosome transmission fidelity protein 8 homolog	Rattus norvegicus (Rat)	mitotic sister chromatid cohesion [GO:0007064]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]		Ctf18 RFC-like complex [GO:0031390]; nucleus [GO:0005634]	GO:0005634; GO:0007064; GO:0031390; GO:1900264
GN002547	GN002547.1	Q9VVY3	47.0	219	450	681	9.77e-50	182	GBS76_DROME	Glycogen-binding subunit 76A (CBM21 domain-containing protein CG9619)	Drosophila melanogaster (Fruit fly)	negative regulation of glycogen catabolic process [GO:0045818]; positive regulation of glycogen biosynthetic process [GO:0045725]; regulation of glycogen biosynthetic process [GO:0005979]	glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]	protein phosphatase type 1 complex [GO:0000164]	GO:0000164; GO:0005979; GO:0008157; GO:0045725; GO:0045818; GO:2001069
GN002548	GN002548.1	Q9BQI3	33.9	637	699	630	1.59e-88	293	E2AK1_HUMAN	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase)	Homo sapiens (Human)	HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hemoglobin biosynthetic process [GO:0046986]; negative regulation of translational initiation by iron [GO:0045993]; positive regulation of mitophagy [GO:1901526]; protein autophosphorylation [GO:0046777]; protein localization to mitochondrion [GO:0070585]; regulation of translational initiation [GO:0006446]; response to iron ion starvation [GO:1990641]	ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; heme binding [GO:0020037]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004694; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006446; GO:0008285; GO:0020037; GO:0042803; GO:0045993; GO:0046777; GO:0046986; GO:0070585; GO:0106310; GO:0140467; GO:0140468; GO:1901526; GO:1990641
GN002549	GN002549.1	Q8N0V3	26.1	203	396	343	2.31e-09	62.0	RBFA_HUMAN	Putative ribosome-binding factor A, mitochondrial	Homo sapiens (Human)	mitochondrial small ribosomal subunit assembly [GO:0180026]; rRNA processing [GO:0006364]	ribosomal small subunit binding [GO:0043024]; rRNA binding [GO:0019843]	methyltransferase complex [GO:0034708]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0006364; GO:0019843; GO:0034708; GO:0043024; GO:0180026
GN002550	GN002550.1	Q9BQ70	50.7	537	639	676	2.44e-176	520	TCF25_HUMAN	Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25)	Homo sapiens (Human)	regulation of protein K48-linked ubiquitination [GO:0061945]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]		cytosol [GO:0005829]; nucleus [GO:0005634]; RQC complex [GO:1990112]	GO:0005634; GO:0005829; GO:0061945; GO:0072344; GO:1990112; GO:1990116
GN002553	GN002553.1	P0DW91	58.6	304	345	410	1.71e-134	392	ZTRF1_BOVIN	Zinc finger TRAF-type-containing protein 1 (Cysteine and histidine-rich protein 1)	Bos taurus (Bovine)			perinuclear region of cytoplasm [GO:0048471]	GO:0048471
GN002554	GN002554.1	Q866D2	31.3	288	338	365	1.28e-41	151	FUT1_LEOFU	Galactoside alpha-(1,2)-fucosyltransferase 1 (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.344)	Leontocebus fuscicollis (Brown-mantled tamarin) (Saguinus fuscicollis)	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; olfactory bulb development [GO:0021772]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion [GO:1904906]; positive regulation of sprouting angiogenesis [GO:1903672]	alpha-(1,2)-fucosyltransferase activity [GO:0031127]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]	Golgi cisterna membrane [GO:0032580]	GO:0001954; GO:0005975; GO:0008107; GO:0009101; GO:0010595; GO:0021772; GO:0031127; GO:0032580; GO:1903672; GO:1904906
GN002556	GN002556.1	W6YKT9	28.9	270	680	644	9.42e-20	97.4	PGH_COCC2	Polyglycine hydrolase (EC 3.4.21.-) (Chitinase modifying protein) (BzCMP)	Cochliobolus carbonum (strain 26-R-13) (Maize leaf spot fungus) (Bipolaris zeicola)	effector-mediated suppression of host defense response [GO:0140590]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]	GO:0004252; GO:0005576; GO:0140590
GN002559	GN002559.1	Q587J7	31.0	697	2066	1177	1.39e-93	335	TDR12_HUMAN	Putative ATP-dependent RNA helicase TDRD12 (EC 3.6.4.13) (ES cell-associated transcript 8 protein) (Tudor domain-containing protein 12)	Homo sapiens (Human)	fertilization [GO:0009566]; germ-line stem cell division [GO:0042078]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	PET complex [GO:1990923]	GO:0003676; GO:0003724; GO:0005524; GO:0007140; GO:0007283; GO:0009566; GO:0016887; GO:0034587; GO:0042078; GO:0141196; GO:1990923
GN002562	GN002562.1	Q8BFZ4	29.1	278	396	434	7.16e-22	100	FXL21_MOUSE	F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) (F-box and leucine-rich repeat protein 3B) (F-box/LRR-repeat protein 3B)	Mus musculus (Mouse)	entrainment of circadian clock by photoperiod [GO:0043153]; protein ubiquitination [GO:0016567]		cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005634; GO:0005829; GO:0016567; GO:0019005; GO:0043153
GN002564	GN002564.1	Q8BFZ4	29.1	278	396	434	7.16e-22	100	FXL21_MOUSE	F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) (F-box and leucine-rich repeat protein 3B) (F-box/LRR-repeat protein 3B)	Mus musculus (Mouse)	entrainment of circadian clock by photoperiod [GO:0043153]; protein ubiquitination [GO:0016567]		cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005634; GO:0005829; GO:0016567; GO:0019005; GO:0043153
GN002566	GN002566.1	P55043	40.0	145	158	306	8.01e-24	97.4	RAD_RAT	GTP-binding protein RAD (RAD1) (Ras associated with diabetes)	Rattus norvegicus (Rat)	negative regulation of cell growth [GO:0030308]	calcium channel regulator activity [GO:0005246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; T-tubule [GO:0030315]	GO:0003924; GO:0005246; GO:0005525; GO:0005886; GO:0030308; GO:0030315
GN002571	GN002571.1	Q3KR54	29.3	605	630	619	3.14e-54	198	ADAD1_RAT	Adenosine deaminase domain-containing protein 1 (Testis nuclear RNA-binding protein)	Rattus norvegicus (Rat)	adenosine to inosine editing [GO:0006382]; RNA processing [GO:0006396]; spermatid development [GO:0007286]	adenosine deaminase activity [GO:0004000]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003723; GO:0003725; GO:0003726; GO:0004000; GO:0005634; GO:0005730; GO:0005737; GO:0006382; GO:0006396; GO:0007286
GN002576	GN002576.1	Q00685	28.4	1558	1662	1673	3.35e-151	509	CO3_LETCA	Complement C3 [Cleaved into: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b (Complement C3b-alpha' chain)]	Lethenteron camtschaticum (Japanese lamprey) (Lampetra japonica)	complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; complement activation, GZMK pathway [GO:0160257]; complement activation, lectin pathway [GO:0001867]; opsonization [GO:0008228]	antigen binding [GO:0003823]; endopeptidase inhibitor activity [GO:0004866]	cell surface [GO:0009986]; classical-complement-pathway C3/C5 convertase complex [GO:0005601]; extracellular region [GO:0005576]; symbiont cell surface [GO:0106139]	GO:0001867; GO:0003823; GO:0004866; GO:0005576; GO:0005601; GO:0006957; GO:0006958; GO:0008228; GO:0009986; GO:0106139; GO:0160257
GN002577	GN002577.1	Q90VV1	40.9	110	275	277	9.74e-17	81.3	HES4B_XENLA	Transcription factor HES-4-B (Hairy and enhancer of split 4-B) (Protein hairy-2) (Xhairy2) (Protein hairy-2a) (Xhairy2b)	Xenopus laevis (African clawed frog)	anterior/posterior pattern specification [GO:0009952]; floor plate development [GO:0033504]; lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest formation [GO:0014029]; prechordal plate formation [GO:0021501]; regulation of neurogenesis [GO:0050767]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0002088; GO:0005634; GO:0009952; GO:0014029; GO:0021501; GO:0033504; GO:0043066; GO:0043565; GO:0045892; GO:0046982; GO:0048642; GO:0050767
GN002578	GN002578.1	Q92002	56.6	1042	1060	1028	0.0	1140	MYO1C_AQUCT	Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) (aMIb)	Aquarana catesbeiana (American bullfrog) (Rana catesbeiana)	actin filament organization [GO:0007015]; actin filament-based movement [GO:0030048]; endocytosis [GO:0006897]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; microvillus [GO:0005902]; myosin complex [GO:0016459]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; stereocilium membrane [GO:0060171]	GO:0000146; GO:0005524; GO:0005737; GO:0005886; GO:0005902; GO:0006897; GO:0007015; GO:0016459; GO:0030048; GO:0031410; GO:0032587; GO:0051015; GO:0060171
GN002582	GN002582.1	O02373	67.8	469	479	476	5.94e-239	665	UGDH_DROME	UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (Protein sugarless) (Protein suppenkasper)	Drosophila melanogaster (Fruit fly)	chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; epithelial cell migration, open tracheal system [GO:0007427]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; mesoderm migration involved in gastrulation [GO:0007509]; segment polarity determination [GO:0007367]; UDP-glucuronate biosynthetic process [GO:0006065]	NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003979; GO:0005634; GO:0005737; GO:0005829; GO:0006024; GO:0006065; GO:0007367; GO:0007427; GO:0007509; GO:0008543; GO:0015012; GO:0050650; GO:0051287
GN002586	GN002586.1	A1Z6E0	72.3	235	237	279	3.24e-128	366	GUS_DROME	Protein gustavus	Drosophila melanogaster (Fruit fly)	cuticle pattern formation [GO:0035017]; dorsal appendage formation [GO:0046843]; germ cell development [GO:0007281]; germ cell migration [GO:0008354]; intracellular protein localization [GO:0008104]; intracellular signal transduction [GO:0035556]; oocyte anterior/posterior axis specification [GO:0007314]; pole plasm assembly [GO:0007315]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; wing disc morphogenesis [GO:0007472]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	cell cortex [GO:0005938]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; elongin complex [GO:0070449]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; pole plasm [GO:0045495]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005634; GO:0005737; GO:0005938; GO:0007281; GO:0007314; GO:0007315; GO:0007472; GO:0008104; GO:0008354; GO:0019005; GO:0031466; GO:0035017; GO:0035556; GO:0043161; GO:0045495; GO:0045732; GO:0046843; GO:0048471; GO:0070449; GO:1990756
GN002587	GN002587.1	P49916	52.3	960	942	1009	0.0	928	DNLI3_HUMAN	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)	Homo sapiens (Human)	base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA biosynthetic process [GO:0071897]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; lagging strand elongation [GO:0006273]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial DNA replication [GO:0090298]; regulation of DNA repair [GO:0006282]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; zinc ion binding [GO:0008270]	DNA ligase III-XRCC1 complex [GO:0070421]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0000724; GO:0003677; GO:0003909; GO:0003910; GO:0005524; GO:0005634; GO:0005654; GO:0005739; GO:0005759; GO:0006273; GO:0006282; GO:0006284; GO:0006287; GO:0006302; GO:0007005; GO:0008270; GO:0043504; GO:0070421; GO:0071897; GO:0090298; GO:0090734; GO:0097681
GN002589	GN002589.1	C6EUD4	59.2	461	469	478	1.47e-189	539	APSCT_FASHE	Succinyl-CoA:acetate/propanoyl-CoA:succinate CoA transferase (EC 2.8.3.18) (EC 2.8.3.27) (Acetate:succinate CoA-transferase) (ASCT) (Propionate:succinate CoA-transferase) (PSCT) (Short-chain acyl-CoA-transferase)	Fasciola hepatica (Liver fluke)	acetate metabolic process [GO:0006083]	acetate CoA-transferase activity [GO:0008775]; propionyl-CoA:succinate CoA-transferase activity [GO:0043821]	mitochondrion [GO:0005739]	GO:0005739; GO:0006083; GO:0008775; GO:0043821
GN002591	GN002591.1	Q54BU4	50.5	598	808	909	8.07e-189	566	ABCB1_DICDI	ABC transporter B family member 1 (ABC transporter ABCB.1)	Dictyostelium discoideum (Social amoeba)	chemotaxis [GO:0006935]; culmination involved in sorocarp development [GO:0031154]; hyperosmotic response [GO:0006972]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	membrane [GO:0016020]	GO:0005524; GO:0006935; GO:0006972; GO:0016020; GO:0016887; GO:0031154; GO:0140359
GN002592	GN002592.1	O00170	48.3	203	202	330	6.64e-63	201	AIP_HUMAN	AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9)	Homo sapiens (Human)	protein localization to mitochondrion [GO:0070585]; protein maturation [GO:0051604]	aryl hydrocarbon receptor binding [GO:0017162]; GAF domain binding [GO:0036004]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding chaperone [GO:0044183]; transcription coactivator activity [GO:0003713]	aryl hydrocarbon receptor complex [GO:0034751]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	GO:0003713; GO:0003755; GO:0005654; GO:0005737; GO:0005829; GO:0016020; GO:0017162; GO:0034751; GO:0036004; GO:0044183; GO:0051604; GO:0070585
GN002602	GN002602.1	Q8K4P0	82.1	56	66	1330	1.14e-28	109	WDR33_MOUSE	pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa)	Mus musculus (Mouse)	mRNA 3'-end processing [GO:0031124]		fibrillar center [GO:0001650]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001650; GO:0005634; GO:0005654; GO:0005847; GO:0031124
GN002604	GN002604.1	Q17QI2	71.7	191	196	194	5.65e-101	292	SSU72_BOVIN	RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16)	Bos taurus (Bovine)	co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; termination of RNA polymerase II transcription [GO:0006369]	RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	cytoplasm [GO:0005737]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]	GO:0005737; GO:0005847; GO:0006369; GO:0008420; GO:0180010
GN002614	GN002614.1	P31795	38.7	111	163	581	5.17e-17	80.5	POL_MLVRK	Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]	Radiation murine leukemia virus (strain Kaplan)	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; symbiont entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826]	nucleic acid binding [GO:0003676]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]		GO:0003676; GO:0003964; GO:0004523; GO:0006310; GO:0015074; GO:0044826; GO:0046718; GO:0075713
GN002626	GN002626.1	Q9Y2C3	32.7	254	297	310	5.13e-35	131	B3GT5_HUMAN	Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)	Homo sapiens (Human)	glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005783; GO:0005794; GO:0008499; GO:0009101; GO:0009312
GN002627	GN002627.1	Q6NXN1	43.6	133	202	152	1.21e-15	73.9	SZRD1_MOUSE	SUZ RNA-binding domain-containing (SUZ domain-containing protein 1)	Mus musculus (Mouse)				
GN002628	GN002628.1	C3ZQF9	22.0	268	328	380	1.69e-09	62.0	QRFPR_BRAFL	QRFP-like peptide receptor	Branchiostoma floridae (Florida lancelet) (Amphioxus)	cellular response to hormone stimulus [GO:0032870]; cellular response to peptide [GO:1901653]; G protein-coupled receptor signaling pathway [GO:0007186]	G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]	plasma membrane [GO:0005886]	GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0032870; GO:1901653
GN002629	GN002629.1	Q4FZX7	53.4	161	172	269	3.22e-49	162	SRPRB_RAT	Signal recognition particle receptor subunit beta (SR-beta)	Rattus norvegicus (Rat)	protein targeting to ER [GO:0045047]	GTP binding [GO:0005525]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; signal recognition particle receptor complex [GO:0005785]	GO:0005525; GO:0005737; GO:0005785; GO:0005789; GO:0005881; GO:0016020; GO:0031625; GO:0045047
GN002633	GN002633.1	Q4FZX7	53.4	161	162	269	3.14e-49	162	SRPRB_RAT	Signal recognition particle receptor subunit beta (SR-beta)	Rattus norvegicus (Rat)	protein targeting to ER [GO:0045047]	GTP binding [GO:0005525]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; signal recognition particle receptor complex [GO:0005785]	GO:0005525; GO:0005737; GO:0005785; GO:0005789; GO:0005881; GO:0016020; GO:0031625; GO:0045047
GN002635	GN002635.1	Q63931	25.8	365	359	430	1.38e-09	62.8	CCKAR_CAVPO	Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R)	Cavia porcellus (Guinea pig)		cholecystokinin receptor activity [GO:0004951]; neuropeptide receptor activity [GO:0008188]; peptide hormone binding [GO:0017046]	plasma membrane [GO:0005886]	GO:0004951; GO:0005886; GO:0008188; GO:0017046
GN002641	GN002641.1	Q8BK67	57.2	435	475	520	2.79e-179	515	RCC2_MOUSE	Protein RCC2	Mus musculus (Mouse)	activation of GTPase activity [GO:0090630]; chromosome passenger complex localization to kinetochore [GO:0072356]; establishment of protein localization [GO:0045184]; focal adhesion assembly [GO:0048041]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GTPase activity [GO:0034260]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; regulation of cell migration [GO:0030334]; regulation of fibroblast migration [GO:0010762]; regulation of ruffle assembly [GO:1900027]	microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]	chromosome [GO:0005694]; chromosome, centromeric core domain [GO:0034506]; early endosome membrane [GO:0031901]; membrane [GO:0016020]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005694; GO:0005730; GO:0005886; GO:0007229; GO:0008017; GO:0010762; GO:0010971; GO:0016020; GO:0019901; GO:0019904; GO:0030334; GO:0030496; GO:0031267; GO:0031901; GO:0034260; GO:0034506; GO:0045184; GO:0048041; GO:0051895; GO:0051987; GO:0072356; GO:0090630; GO:1900025; GO:1900027; GO:1990023
GN002650	GN002650.1	A2A8L1	54.0	1914	2070	1946	0.0	1798	CHD5_MOUSE	ATP-dependent chromatin remodeler CHD5 (EC 3.6.4.-) (Chromo domain-containing protein 5) (CHD-5)	Mus musculus (Mouse)	cerebral cortex neuron differentiation [GO:0021895]; chromatin remodeling [GO:0006338]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; regulation of cell differentiation [GO:0045595]; sperm DNA condensation [GO:0035092]; transcription by RNA polymerase II [GO:0006366]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; histone H3K27me3 reader activity [GO:0061628]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]	GO:0000122; GO:0000785; GO:0000792; GO:0003677; GO:0003682; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0006338; GO:0006366; GO:0008285; GO:0016581; GO:0016607; GO:0016887; GO:0021895; GO:0035092; GO:0042393; GO:0042826; GO:0045595; GO:0061628; GO:0140658; GO:1901798
GN002653	GN002653.1	Q90963	67.3	49	121	165	5.55e-14	67.4	PRRX2_CHICK	Paired mesoderm homeobox protein 2 (PRX-2)	Gallus gallus (Chicken)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357
GN002656	GN002656.1	Q6P4Y1	42.0	440	458	510	1.40e-80	261	BANP_XENTR	Protein BANP	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		DNA binding [GO:0003677]	nucleus [GO:0005634]	GO:0003677; GO:0005634
GN002657	GN002657.1	Q9VPQ6	23.2	896	1228	1191	3.10e-26	120	USH_DROME	Zinc finger protein ush (Protein U-shaped)	Drosophila melanogaster (Fruit fly)	amnioserosa maintenance [GO:0046665]; cell differentiation [GO:0030154]; chaeta development [GO:0022416]; compound eye development [GO:0048749]; germ-band shortening [GO:0007390]; heart development [GO:0007507]; larval lymph gland hemopoiesis [GO:0035167]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; lymph gland plasmatocyte differentiation [GO:0035169]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hemocyte differentiation [GO:0045611]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of antibacterial peptide biosynthetic process [GO:0006963]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription repressor activity [GO:0001217]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]	GO:0000122; GO:0001217; GO:0003714; GO:0005634; GO:0006355; GO:0006963; GO:0007390; GO:0007507; GO:0022416; GO:0030154; GO:0035167; GO:0035169; GO:0035170; GO:0045611; GO:0045892; GO:0045944; GO:0046627; GO:0046665; GO:0048542; GO:0048749; GO:0061629
GN002658	GN002658.1	Q9NY26	31.1	315	317	324	6.68e-27	110	S39A1_HUMAN	Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1)	Homo sapiens (Human)	monoatomic cation transport [GO:0006812]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	signaling receptor binding [GO:0005102]; transmembrane transporter activity [GO:0022857]; zinc ion transmembrane transporter activity [GO:0005385]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005102; GO:0005385; GO:0005789; GO:0005886; GO:0006812; GO:0016020; GO:0022857; GO:0071577; GO:0071578
GN002659	GN002659.1	Q96T60	58.2	287	584	521	2.02e-115	356	PNKP_HUMAN	Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]	Homo sapiens (Human)	base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via nonhomologous end joining [GO:0006303]; nucleotide-excision repair [GO:0006289]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of telomere maintenance [GO:0032206]; regulation of DNA repair [GO:0006282]; response to oxidative stress [GO:0006979]; response to radiation [GO:0009314]; single strand break repair [GO:0000012]	ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; damaged DNA binding [GO:0003684]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; polynucleotide 3'-phosphatase activity [GO:0046403]; purine nucleotide binding [GO:0017076]	chromosome [GO:0005694]; DNA ligase III-XRCC1 complex [GO:0070421]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]	GO:0000012; GO:0003684; GO:0003690; GO:0004519; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0006261; GO:0006281; GO:0006282; GO:0006284; GO:0006287; GO:0006289; GO:0006303; GO:0006979; GO:0009314; GO:0016020; GO:0017076; GO:0032206; GO:0035861; GO:0046403; GO:0046404; GO:0070421; GO:0090734; GO:2001034
GN002660	GN002660.1	O94983	29.1	1278	1311	1202	1.42e-89	320	CMTA2_HUMAN	Calmodulin-binding transcription activator 2	Homo sapiens (Human)	cardiac muscle hypertrophy in response to stress [GO:0014898]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0003682; GO:0003712; GO:0003713; GO:0005634; GO:0005654; GO:0006357; GO:0014898; GO:0042826; GO:0043565; GO:0045944
GN002666	GN002666.1	Q15021	47.2	125	218	1401	4.71e-29	117	CND1_HUMAN	Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog)	Homo sapiens (Human)	mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]	histone binding [GO:0042393]	condensed chromosome [GO:0000793]; condensed chromosome, centromeric region [GO:0000779]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000779; GO:0000793; GO:0000796; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0007076; GO:0016020; GO:0042393; GO:1905821
GN002667	GN002667.1	P52786	27.4	168	201	501	1.38e-12	68.9	CP2J1_RABIT	Cytochrome P450 2J1 (EC 1.14.14.1) (CYPIIJ1) (Cytochrome P-450IB)	Oryctolagus cuniculus (Rabbit)	xenobiotic metabolic process [GO:0006805]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005789; GO:0006805; GO:0016712; GO:0020037
GN002668	GN002668.1	A0A2P1DP94	30.0	140	191	536	6.00e-13	69.7	MACC_PENTR	Cytochrome P450 monooxygenase macC (EC 1.-.-.-) (Macrophorins biosynthesis cluster protein C)	Penicillium terrestre	mycotoxin biosynthetic process [GO:0043386]; terpenoid biosynthetic process [GO:0016114]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	membrane [GO:0016020]	GO:0004497; GO:0005506; GO:0016020; GO:0016114; GO:0016705; GO:0020037; GO:0043386
GN002669	GN002669.1	P05185	38.3	175	178	509	4.67e-34	128	CP17A_BOVIN	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)	Bos taurus (Bovine)	glucocorticoid biosynthetic process [GO:0006704]; hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid metabolic process [GO:0008202]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	endoplasmic reticulum membrane [GO:0005789]	GO:0004508; GO:0005506; GO:0005789; GO:0006704; GO:0008202; GO:0020037; GO:0042446; GO:0042448
GN002670	GN002670.1	Q29497	27.3	476	519	509	9.04e-54	192	CP17A_SHEEP	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)	Ovis aries (Sheep)	glucocorticoid biosynthetic process [GO:0006704]; hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid metabolic process [GO:0008202]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	endoplasmic reticulum membrane [GO:0005789]	GO:0004508; GO:0005506; GO:0005789; GO:0006704; GO:0008202; GO:0020037; GO:0042446; GO:0042448
GN002671	GN002671.1	Q9QUP4	24.3	366	405	395	8.59e-15	79.0	CHST5_MOUSE	Carbohydrate sulfotransferase 5 (EC 2.8.2.21) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4) (GST4) (Intestinal N-acetylglucosamine-6-O-sulfotransferase) (I-GlcNAc6ST) (Intestinal GlcNAc-6-sulfotransferase) (mIGn6ST) (N-acetylglucosamine 6-O-sulfotransferase 3) (GlcNAc6ST-3) (Gn6st-3)	Mus musculus (Mouse)	carbohydrate metabolic process [GO:0005975]; keratan sulfate proteoglycan biosynthetic process [GO:0018146]; N-acetylglucosamine metabolic process [GO:0006044]; sulfur compound metabolic process [GO:0006790]	keratan sulfotransferase activity [GO:0045130]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0001517; GO:0005794; GO:0005802; GO:0005975; GO:0006044; GO:0006790; GO:0018146; GO:0045130
GN002672	GN002672.1	Q7Z569	45.7	619	632	592	2.03e-165	488	BRAP_HUMAN	BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63)	Homo sapiens (Human)	MAPK cascade [GO:0000165]; negative regulation of signal transduction [GO:0009968]; protein ubiquitination [GO:0016567]; Ras protein signal transduction [GO:0007265]	identical protein binding [GO:0042802]; nuclear localization sequence binding [GO:0008139]; nucleic acid binding [GO:0003676]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000165; GO:0003676; GO:0004842; GO:0005737; GO:0005829; GO:0007265; GO:0008139; GO:0008270; GO:0009968; GO:0016567; GO:0042802; GO:0061630
GN002673	GN002673.1	Q9EST3	33.5	486	1371	983	1.58e-35	150	4ET_MOUSE	Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (CD40 ligand-activated specific transcript 4) (Eukaryotic translation initiation factor 4E nuclear import factor 1)	Mus musculus (Mouse)	miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; mRNA stabilization [GO:0048255]; negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0106289]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; P-body assembly [GO:0033962]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; protein import into nucleus [GO:0006606]; stem cell population maintenance [GO:0019827]	kinase binding [GO:0019900]; mRNA binding [GO:0003729]; nuclear export signal receptor activity [GO:0005049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]; PML body [GO:0016605]	GO:0000932; GO:0003729; GO:0005049; GO:0005634; GO:0005737; GO:0005829; GO:0006606; GO:0016605; GO:0016607; GO:0017148; GO:0019827; GO:0019900; GO:0033962; GO:0035278; GO:0045665; GO:0048255; GO:0060213; GO:0106289
GN002674	GN002674.1	P56399	55.0	856	798	858	0.0	926	UBP5_MOUSE	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)	Mus musculus (Mouse)	negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; protein K48-linked deubiquitination [GO:0071108]; regulation of mitotic cell cycle [GO:0007346]; regulation protein catabolic process at presynapse [GO:0140251]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; presynapse [GO:0098793]	GO:0002841; GO:0004843; GO:0005634; GO:0005737; GO:0007346; GO:0008270; GO:0010494; GO:0032435; GO:0032436; GO:0043130; GO:0045727; GO:0045944; GO:0050868; GO:0071108; GO:0098793; GO:0101005; GO:0140251; GO:2000059
GN002676	GN002676.1	O75381	38.9	239	333	377	5.53e-41	150	PEX14_HUMAN	Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14)	Homo sapiens (Human)	cellular response to reactive oxygen species [GO:0034614]; microtubule anchoring [GO:0034453]; negative regulation of DNA-templated transcription [GO:0045892]; peroxisome organization [GO:0007031]; peroxisome transport along microtubule [GO:0036250]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein-containing complex assembly [GO:0065003]	beta-tubulin binding [GO:0048487]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor binding [GO:0005102]; transmembrane protein transporter activity [GO:0008320]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	GO:0005102; GO:0005634; GO:0005777; GO:0005778; GO:0005829; GO:0007031; GO:0008017; GO:0008320; GO:0016020; GO:0016558; GO:0016560; GO:0016561; GO:0030674; GO:0032991; GO:0034453; GO:0034614; GO:0036250; GO:0042802; GO:0044721; GO:0045892; GO:0048487; GO:0065003; GO:1990429
GN002677	GN002677.1	O70302	44.2	77	199	217	7.62e-12	65.1	CIDEA_MOUSE	Lipid transferase CIDEA (Cell death activator CIDE-A) (Cell death-inducing DFFA-like effector A)	Mus musculus (Mouse)	apoptotic process [GO:0006915]; cellular response to cold [GO:0070417]; fat cell differentiation [GO:0045444]; lipid droplet fusion [GO:0160077]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of cytokine production [GO:0001818]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of tumor necrosis factor production [GO:0032720]; regulation of apoptotic DNA fragmentation [GO:1902510]; response to stilbenoid [GO:0035634]; temperature homeostasis [GO:0001659]	lipid transfer activity [GO:0120013]; phosphatidic acid binding [GO:0070300]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; mitochondrial envelope [GO:0005740]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0001659; GO:0001818; GO:0005634; GO:0005737; GO:0005739; GO:0005740; GO:0005811; GO:0005829; GO:0006629; GO:0006915; GO:0019915; GO:0030512; GO:0032720; GO:0035634; GO:0042803; GO:0045444; GO:0050995; GO:0070300; GO:0070417; GO:0120013; GO:0120163; GO:0160077; GO:1900118; GO:1902510
GN002678	GN002678.1	Q06846	44.6	711	665	704	2.33e-162	486	RP3A_BOVIN	Rabphilin-3A (Exophilin-1)	Bos taurus (Bovine)	calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; intracellular protein transport [GO:0006886]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; small GTPase binding [GO:0031267]	dendritic spine [GO:0043197]; extrinsic component of synaptic vesicle membrane [GO:0098850]; membrane [GO:0016020]; neuron projection [GO:0043005]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0005509; GO:0005544; GO:0006886; GO:0016020; GO:0031267; GO:0043005; GO:0043197; GO:0045202; GO:0045211; GO:0045956; GO:0098850; GO:0099502
GN002680	GN002680.1	Q8IWY8	29.2	161	306	852	3.81e-09	61.2	ZSC29_HUMAN	Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690)	Homo sapiens (Human)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:1990837
GN002688	GN002688.1	Q3SZH6	51.2	539	522	461	3.26e-188	537	TTLL9_BOVIN	Probable tubulin polyglutamylase TTLL9 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 9)	Bos taurus (Bovine)	microtubule cytoskeleton organization [GO:0000226]	ATP binding [GO:0005524]; protein-glutamic acid ligase activity, elongating [GO:0106438]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	ciliary basal body [GO:0036064]	GO:0000226; GO:0005524; GO:0015631; GO:0036064; GO:0070740; GO:0106438
GN002690	GN002690.1	Q93243	42.1	76	132	765	3.18e-09	57.0	NAS37_CAEEL	Zinc metalloproteinase nas-37 (EC 3.4.24.-) (Nematode astacin 37)	Caenorhabditis elegans	collagen and cuticulin-based cuticle development [GO:0040002]; ecdysis, collagen and cuticulin-based cuticle [GO:0042395]; molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0004222; GO:0005576; GO:0006508; GO:0008270; GO:0018996; GO:0040002; GO:0042395
GN002691	GN002691.1	Q60414	32.1	302	480	348	3.41e-35	137	NTCP2_CRIGR	Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)		bile acid:sodium symporter activity [GO:0008508]	apical plasma membrane [GO:0016324]	GO:0008508; GO:0016324
GN002692	GN002692.1	B4LZT9	28.7	164	1348	483	6.45e-10	67.0	HH_DROVI	Protein hedgehog (EC 3.1.-.-) [Cleaved into: Protein hedgehog N-product]	Drosophila virilis (Fruit fly)	cell fate specification [GO:0001708]; cell-cell signaling [GO:0007267]; intein-mediated protein splicing [GO:0016539]; protein autoprocessing [GO:0016540]; regulation of gene expression [GO:0010468]; segment polarity determination [GO:0007367]; smoothened signaling pathway [GO:0007224]; system development [GO:0048731]	calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; endopeptidase activity [GO:0004175]; patched binding [GO:0005113]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0001708; GO:0004175; GO:0005113; GO:0005509; GO:0005634; GO:0005737; GO:0005886; GO:0007224; GO:0007267; GO:0007367; GO:0010468; GO:0016539; GO:0016540; GO:0048731; GO:0140853
GN002699	GN002699.1	O60308	43.1	941	897	925	5.80e-234	686	CE104_HUMAN	Centrosomal protein of 104 kDa (Cep104)	Homo sapiens (Human)		identical protein binding [GO:0042802]	centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; spindle pole [GO:0000922]	GO:0000922; GO:0005813; GO:0005814; GO:0005929; GO:0042802
GN002700	GN002700.1	A7RRJ0	72.1	377	376	377	2.04e-193	541	FEN1_NEMVE	Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1)	Nematostella vectensis (Starlet sea anemone)	base-excision repair [GO:0006284]; DNA replication, removal of RNA primer [GO:0043137]	5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; DNA binding [GO:0003677]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; RNA-DNA hybrid ribonuclease activity [GO:0004523]	mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0003677; GO:0004523; GO:0005634; GO:0005654; GO:0005730; GO:0005739; GO:0006284; GO:0008409; GO:0017108; GO:0030145; GO:0043137
GN002701	GN002701.1	Q4KTY1	82.8	418	410	415	6.81e-231	639	KPSH1_PINFU	Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)	Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata)		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]		GO:0004674; GO:0005524; GO:0106310
GN002702	GN002702.1	Q4KTY1	86.4	301	340	415	6.44e-185	520	KPSH1_PINFU	Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)	Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata)		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]		GO:0004674; GO:0005524; GO:0106310
GN002703	GN002703.1	Q4KTY1	75.3	93	90	415	1.57e-21	89.7	KPSH1_PINFU	Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1)	Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata)		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]		GO:0004674; GO:0005524; GO:0106310
GN002704	GN002704.1	P58390	39.3	420	457	574	4.98e-88	282	KCNN2_MOUSE	Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)	Mus musculus (Mouse)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; modulation of chemical synaptic transmission [GO:0050804]; monoatomic ion transport [GO:0006811]; positive regulation of potassium ion transport [GO:0043268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of potassium ion transmembrane transport [GO:1901379]	alpha-actinin binding [GO:0051393]; calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; monoatomic ion channel activity [GO:0005216]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; small conductance calcium-activated potassium channel activity [GO:0016286]	cell surface [GO:0009986]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; smooth endoplasmic reticulum [GO:0005790]; T-tubule [GO:0030315]; Z disc [GO:0030018]	GO:0005216; GO:0005242; GO:0005516; GO:0005790; GO:0005886; GO:0006811; GO:0006813; GO:0009986; GO:0015269; GO:0016020; GO:0016286; GO:0019904; GO:0030018; GO:0030315; GO:0042383; GO:0042803; GO:0043025; GO:0043197; GO:0043268; GO:0045211; GO:0048168; GO:0050804; GO:0051393; GO:0071805; GO:0098914; GO:0098978; GO:1901379
GN002705	GN002705.1	H2A0L1	34.9	301	738	456	4.62e-43	165	TYRO2_PINMG	Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2)	Margaritifera margaritifera (Freshwater pearl mussel)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN002706	GN002706.1	Q8TB52	36.7	79	539	745	1.65e-09	64.3	FBX30_HUMAN	F-box only protein 30	Homo sapiens (Human)	protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005829; GO:0008270; GO:0016567; GO:0019005; GO:0031146; GO:0061630
GN002707	GN002707.1	Q19673	35.6	303	719	693	1.13e-43	171	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN002708	GN002708.1	P86952	38.1	210	672	456	1.15e-28	123	TYRO_PINMA	Tyrosinase-like protein (Tyrosinase-2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN002717	GN002717.1	P05090	39.4	109	110	189	1.22e-17	77.0	APOD_HUMAN	Apolipoprotein D (Apo-D) (ApoD)	Homo sapiens (Human)	angiogenesis [GO:0001525]; brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246]	cholesterol binding [GO:0015485]; lipid carrier activity [GO:0005319]	cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]	GO:0000302; GO:0001525; GO:0005319; GO:0005576; GO:0006006; GO:0006629; GO:0006869; GO:0007420; GO:0010642; GO:0014012; GO:0015485; GO:0022626; GO:0030425; GO:0042246; GO:0042308; GO:0043025; GO:0048471; GO:0048662; GO:0048678; GO:0051895; GO:0060588; GO:0070062; GO:0071638; GO:1900016; GO:2000098; GO:2000405
GN002719	GN002719.1	P51909	39.9	183	182	189	3.75e-41	140	APOD_CAVPO	Apolipoprotein D (Apo-D) (ApoD)	Cavia porcellus (Guinea pig)	brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246]	cholesterol binding [GO:0015485]	cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]	GO:0000302; GO:0005576; GO:0006006; GO:0006629; GO:0006869; GO:0007420; GO:0010642; GO:0014012; GO:0015485; GO:0022626; GO:0030425; GO:0042246; GO:0042308; GO:0043025; GO:0048471; GO:0048662; GO:0048678; GO:0051895; GO:0060588; GO:0071638; GO:1900016; GO:2000098; GO:2000405
GN002721	GN002721.1	P05090	44.0	109	119	189	1.76e-20	84.7	APOD_HUMAN	Apolipoprotein D (Apo-D) (ApoD)	Homo sapiens (Human)	angiogenesis [GO:0001525]; brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246]	cholesterol binding [GO:0015485]; lipid carrier activity [GO:0005319]	cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]	GO:0000302; GO:0001525; GO:0005319; GO:0005576; GO:0006006; GO:0006629; GO:0006869; GO:0007420; GO:0010642; GO:0014012; GO:0015485; GO:0022626; GO:0030425; GO:0042246; GO:0042308; GO:0043025; GO:0048471; GO:0048662; GO:0048678; GO:0051895; GO:0060588; GO:0070062; GO:0071638; GO:1900016; GO:2000098; GO:2000405
GN002723	GN002723.1	P51909	35.6	118	118	189	2.06e-18	79.3	APOD_CAVPO	Apolipoprotein D (Apo-D) (ApoD)	Cavia porcellus (Guinea pig)	brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246]	cholesterol binding [GO:0015485]	cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]	GO:0000302; GO:0005576; GO:0006006; GO:0006629; GO:0006869; GO:0007420; GO:0010642; GO:0014012; GO:0015485; GO:0022626; GO:0030425; GO:0042246; GO:0042308; GO:0043025; GO:0048471; GO:0048662; GO:0048678; GO:0051895; GO:0060588; GO:0071638; GO:1900016; GO:2000098; GO:2000405
GN002724	GN002724.1	P34269	34.7	308	373	601	2.46e-50	181	TYR1_CAEEL	Putative tyrosinase-like protein tyr-1	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN002726	GN002726.1	F4KGU4	31.8	1531	2906	1775	8.79e-209	691	DEAHC_ARATH	ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)	Arabidopsis thaliana (Mouse-ear cress)	protein targeting [GO:0006605]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]; zinc ion binding [GO:0008270]	chloroplast [GO:0009507]; endosome [GO:0005768]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0004386; GO:0005524; GO:0005634; GO:0005768; GO:0006605; GO:0008270; GO:0009507; GO:0016887
GN002728	GN002728.1	F4KGU4	32.3	1517	2642	1775	1.26e-211	696	DEAHC_ARATH	ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)	Arabidopsis thaliana (Mouse-ear cress)	protein targeting [GO:0006605]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]; zinc ion binding [GO:0008270]	chloroplast [GO:0009507]; endosome [GO:0005768]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0004386; GO:0005524; GO:0005634; GO:0005768; GO:0006605; GO:0008270; GO:0009507; GO:0016887
GN002730	GN002730.1	F4KGU4	31.5	1529	1876	1775	3.39e-207	670	DEAHC_ARATH	ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)	Arabidopsis thaliana (Mouse-ear cress)	protein targeting [GO:0006605]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]; zinc ion binding [GO:0008270]	chloroplast [GO:0009507]; endosome [GO:0005768]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0004386; GO:0005524; GO:0005634; GO:0005768; GO:0006605; GO:0008270; GO:0009507; GO:0016887
GN002732	GN002732.1	O15995	48.0	427	440	424	1.12e-122	366	CCNE_HEMPU	G1/S-specific cyclin-E	Hemicentrotus pulcherrimus (Sea urchin) (Strongylocentrotus pulcherrimus)			nucleus [GO:0005634]	GO:0005634
GN002733	GN002733.1	Q1NZ26	58.5	171	409	277	4.45e-56	189	YSMU_CAEEL	Uncharacterized protein F13E9.13, mitochondrial	Caenorhabditis elegans			mitochondrion [GO:0005739]	GO:0005739
GN002734	GN002734.1	Q91X96	54.4	114	120	123	3.56e-41	135	MSS4_MOUSE	Guanine nucleotide exchange factor MSS4 (Rab-interacting factor)	Mus musculus (Mouse)	post-Golgi vesicle-mediated transport [GO:0006892]; small GTPase-mediated signal transduction [GO:0007264]	guanyl-nucleotide exchange factor activity [GO:0005085]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; membrane [GO:0016020]	GO:0005085; GO:0005829; GO:0006892; GO:0007264; GO:0008270; GO:0016020
GN002735	GN002735.1	P44121	38.3	253	477	268	1.69e-51	178	DNLI_HAEIN	DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]	ATP binding [GO:0005524]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase (NAD+) activity [GO:0003911]		GO:0003910; GO:0003911; GO:0005524; GO:0006281; GO:0006310
GN002736	GN002736.1	Q9WTK3	44.5	382	444	621	7.79e-103	322	GPAA1_MOUSE	GPI-anchor transamidase component GPAA1 (GAA1 protein homolog) (mGAA1) (Glycosylphosphatidylinositol anchor attachment 1 protein) (GPI anchor attachment protein 1)	Mus musculus (Mouse)	attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; GPI anchored protein biosynthesis [GO:0180046]	GPI anchor binding [GO:0034235]; GPI-anchor transamidase activity [GO:0003923]	centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0003923; GO:0005739; GO:0005783; GO:0005789; GO:0005813; GO:0005829; GO:0005886; GO:0006506; GO:0016255; GO:0034235; GO:0042765; GO:0180046
GN002738	GN002738.1	P00125	54.5	266	327	325	1.63e-94	286	CY1_BOVIN	Cytochrome c1, heme protein, mitochondrial (EC 7.1.1.8) (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)	Bos taurus (Bovine)	mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	heme binding [GO:0020037]; quinol-cytochrome-c reductase activity [GO:0008121]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex III [GO:0045275]	GO:0005739; GO:0005743; GO:0006122; GO:0008121; GO:0020037; GO:0045275
GN002739	GN002739.1	P08059	72.1	476	476	558	3.96e-261	724	G6PI_PIG	Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (D-hexose-6-phosphate anomerase) (Glucose-6-phosphate C2-epimerase) (EC 5.1.3.-) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)	Sus scrofa (Pig)	canonical glycolysis [GO:0061621]; fructose 6-phosphate metabolic process [GO:0006002]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glycolytic process [GO:0006096]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of immunoglobulin production [GO:0002639]	carbohydrate derivative binding [GO:0097367]; glucose-6-phosphate 1-epimerase activity [GO:0047938]; glucose-6-phosphate isomerase activity [GO:0004347]; monosaccharide binding [GO:0048029]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]; ubiquitin protein ligase binding [GO:0031625]	ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]	GO:0002639; GO:0004347; GO:0005576; GO:0005737; GO:0005829; GO:0006002; GO:0006094; GO:0006096; GO:0010595; GO:0016857; GO:0031625; GO:0047938; GO:0048029; GO:0051156; GO:0060170; GO:0061621; GO:0097367
GN002741	GN002741.1	Q9I8M9	39.1	128	206	218	1.11e-25	102	TWS1B_XENLA	Twisted gastrulation protein homolog 1-B	Xenopus laevis (African clawed frog)	regulation of BMP signaling pathway [GO:0030510]		extracellular region [GO:0005576]	GO:0005576; GO:0030510
GN002744	GN002744.1	Q6P4M5	45.4	291	287	390	1.04e-86	267	GFOD1_XENTR	Glucose-fructose oxidoreductase domain-containing protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]	extracellular region [GO:0005576]	GO:0000166; GO:0005576; GO:0042802
GN002745	GN002745.1	P08761	44.8	181	191	246	3.45e-46	155	MSRA_DROME	Peptide methionine sulfoxide reductase (EC 1.8.4.11) (Ecdysone-induced protein 28/29 kDa) (Methionine-S-sulfoxide reductase) (Peptide-methionine (S)-S-oxide reductase)	Drosophila melanogaster (Fruit fly)	cellular response to oxidative stress [GO:0034599]; determination of adult lifespan [GO:0008340]; response to oxidative stress [GO:0006979]; sulfur amino acid metabolic process [GO:0000096]	L-methionine (S)-S-oxide reductase activity [GO:0033744]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113]	mitochondrion [GO:0005739]	GO:0000096; GO:0005739; GO:0006979; GO:0008113; GO:0008340; GO:0033744; GO:0034599
GN002746	GN002746.1	Q7TQE7	53.2	331	452	519	3.38e-121	366	MACA2_MOUSE	Putative tyrosine carboxypeptidase MATCAP2 (EC 3.4.17.-)	Mus musculus (Mouse)				
GN002747	GN002747.1	C7G3A0	44.0	141	137	391	1.13e-27	108	MPPE1_CRIGR	Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; GPI anchor biosynthetic process [GO:0006506]; GPI anchor remodelling [GO:0120574]	GPI anchor binding [GO:0034235]; GPI-mannose ethanolamine phosphate phosphodiesterase activity [GO:0062050]; manganese ion binding [GO:0030145]	endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]	GO:0005794; GO:0006506; GO:0006888; GO:0030145; GO:0033116; GO:0034235; GO:0062050; GO:0070971; GO:0120574
GN002748	GN002748.1	F4KGU4	31.7	1509	1716	1775	8.73e-213	681	DEAHC_ARATH	ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)	Arabidopsis thaliana (Mouse-ear cress)	protein targeting [GO:0006605]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]; zinc ion binding [GO:0008270]	chloroplast [GO:0009507]; endosome [GO:0005768]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0004386; GO:0005524; GO:0005634; GO:0005768; GO:0006605; GO:0008270; GO:0009507; GO:0016887
GN002750	GN002750.1	Q9VCA2	32.2	258	255	548	1.92e-28	116	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN002752	GN002752.1	Q55CU8	29.3	184	344	364	6.53e-16	81.3	PITC_DICDI	Phosphatidylinositol transfer protein 3 (CRAL-TRIO domain-containing protein pitC) (Random slug protein 5)	Dictyostelium discoideum (Social amoeba)		phosphatidylinositol transfer activity [GO:0008526]		GO:0008526
GN002755	GN002755.1	Q96MM6	32.9	627	568	686	1.13e-93	304	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN002756	GN002756.1	Q58CW6	29.5	173	294	703	5.58e-09	60.5	CARTF_BOVIN	Calcium-responsive transcription factor (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein)	Bos taurus (Bovine)	cellular response to calcium ion [GO:0071277]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0003677; GO:0005634; GO:0006357; GO:0071277
GN002757	GN002757.1	P56590	31.1	463	486	524	8.57e-76	250	CP1A1_CANLF	Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (Cytochrome P450 form 6) (Cytochrome P450-C) (Cytochrome P450-P1) (DAH1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)	Canis lupus familiaris (Dog) (Canis familiaris)	estrogen metabolic process [GO:0008210]; fatty acid metabolic process [GO:0006631]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; toxin metabolic process [GO:0009404]; xenobiotic catabolic process [GO:0042178]	arachidonate 11,12-epoxygenase activity [GO:0008405]; arachidonate 14,15-epoxygenase activity [GO:0008404]; arachidonate 8,9-epoxygenase activity [GO:0106302]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; fatty acid omega-1 hydroxylase activity [GO:0120502]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005506; GO:0005737; GO:0005739; GO:0005743; GO:0005789; GO:0006631; GO:0006706; GO:0008210; GO:0008395; GO:0008404; GO:0008405; GO:0009404; GO:0016712; GO:0020037; GO:0030544; GO:0042178; GO:0042572; GO:0051879; GO:0101020; GO:0101021; GO:0106256; GO:0106302; GO:0120502
GN002758	GN002758.1	A7SXZ6	83.9	335	335	335	2.32e-213	588	OSGEP_NEMVE	Probable tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep) (tRNA threonylcarbamoyladenosine biosynthesis protein osgep)	Nematostella vectensis (Starlet sea anemone)	tRNA threonylcarbamoyladenosine modification [GO:0002949]	tRNA N(6)-L-threonylcarbamoyladenine synthase activity [GO:0061711]	cytoplasm [GO:0005737]; EKC/KEOPS complex [GO:0000408]; nucleus [GO:0005634]	GO:0000408; GO:0002949; GO:0005634; GO:0005737; GO:0061711
GN002760	GN002760.1	Q2XWK0	57.4	519	526	548	1.78e-200	572	SVOP_XENLA	Synaptic vesicle 2-related protein (SV2-related protein)	Xenopus laevis (African clawed frog)		transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; synaptic vesicle membrane [GO:0030672]	GO:0016020; GO:0022857; GO:0030672
GN002761	GN002761.1	Q3T0Z5	38.9	303	300	263	3.55e-40	144	LENG1_BOVIN	Leukocyte receptor cluster member 1 homolog	Bos taurus (Bovine)				
GN002763	GN002763.1	Q5SVZ6	34.1	126	181	1142	1.49e-09	59.7	ZMYM1_HUMAN	Zinc finger MYM-type protein 1	Homo sapiens (Human)		protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0005634; GO:0008270; GO:0046983
GN002764	GN002764.1	O15247	36.0	236	249	247	1.10e-36	132	CLIC2_HUMAN	Chloride intracellular channel protein 2 (Glutaredoxin-like oxidoreductase CLIC2) (EC 1.8.-.-) (Glutaredoxin-like peroxidase CLIC2) (EC 1.11.1.-) (XAP121)	Homo sapiens (Human)	chloride transport [GO:0006821]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; signal transduction [GO:0007165]	chloride channel activity [GO:0005254]; glutathione peroxidase activity [GO:0004602]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0004602; GO:0005254; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006821; GO:0007165; GO:0010880; GO:0010881; GO:0016020
GN002765	GN002765.1	Q12962	76.7	103	224	218	9.40e-49	162	TAF10_HUMAN	Transcription initiation factor TFIID subunit 10 (STAF28) (Transcription initiation factor TFIID 30 kDa subunit) (TAF(II)30) (TAFII-30) (TAFII30)	Homo sapiens (Human)	allantois development [GO:1905069]; chromatin remodeling [GO:0006338]; DNA-templated transcription initiation [GO:0006352]; embryonic placenta development [GO:0001892]; lateral mesodermal cell differentiation [GO:0048371]; limb development [GO:0060173]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; SAGA complex assembly [GO:0036285]; somitogenesis [GO:0001756]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase binding [GO:0070063]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; transcription preinitiation complex [GO:0097550]	GO:0000124; GO:0001756; GO:0001892; GO:0003677; GO:0005634; GO:0005654; GO:0005669; GO:0005737; GO:0006282; GO:0006338; GO:0006352; GO:0006355; GO:0006357; GO:0006366; GO:0006367; GO:0016251; GO:0019899; GO:0030331; GO:0033276; GO:0036285; GO:0042789; GO:0042802; GO:0043484; GO:0045893; GO:0048371; GO:0048471; GO:0051123; GO:0060173; GO:0060261; GO:0070063; GO:0097550; GO:1905069; GO:1990841
GN002766	GN002766.1	Q2YDN1	31.6	291	577	528	2.68e-33	137	GP161_BOVIN	G protein-coupled receptor 161	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; limb development [GO:0060173]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; regulation of neuron migration [GO:2001222]; skeletal system development [GO:0001501]	G protein-coupled receptor activity [GO:0004930]; signaling adaptor activity [GO:0035591]	non-motile cilium membrane [GO:0098804]; recycling endosome [GO:0055037]	GO:0001501; GO:0004930; GO:0007189; GO:0021549; GO:0030900; GO:0035591; GO:0055037; GO:0060173; GO:0098804; GO:1901621; GO:2001222
GN002769	GN002769.1	Q8CDI7	22.2	1078	1064	1110	4.79e-33	142	CC150_MOUSE	Coiled-coil domain-containing protein 150	Mus musculus (Mouse)				
GN002770	GN002770.1	Q8IZH2	54.0	1207	1865	1706	0.0	1245	XRN1_HUMAN	5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)	Homo sapiens (Human)	cellular response to cycloheximide [GO:0071409]; cellular response to puromycin [GO:1905795]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; histone mRNA catabolic process [GO:0071044]; mRNA catabolic process [GO:0006402]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation [GO:0017148]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; response to testosterone [GO:0033574]; rRNA catabolic process [GO:0016075]	5'-3' RNA exonuclease activity [GO:0004534]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; RNA decapping complex [GO:0098745]	GO:0000288; GO:0000290; GO:0000932; GO:0000956; GO:0002151; GO:0003723; GO:0004534; GO:0005634; GO:0005829; GO:0005886; GO:0006402; GO:0016020; GO:0016075; GO:0017148; GO:0030425; GO:0032211; GO:0033574; GO:0043025; GO:0051880; GO:0070034; GO:0071028; GO:0071044; GO:0071409; GO:0098745; GO:1905795
GN002773	GN002773.1	Q60HE5	62.1	66	119	656	9.75e-26	103	MTHR_MACFA	Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	L-methionine metabolic process [GO:0006555]; tetrahydrofolate interconversion [GO:0035999]	FAD binding [GO:0071949]; methylenetetrahydrofolate reductase (NADPH) activity [GO:0106313]	cytosol [GO:0005829]	GO:0005829; GO:0006555; GO:0035999; GO:0071949; GO:0106313
GN002774	GN002774.1	Q6NSJ0	42.5	567	668	714	3.25e-147	447	MYORG_HUMAN	Alpha-galactosidase MYORG (EC 3.2.1.22) (Myogenesis regulating glycosidase) (Nuclear envelope transmembrane protein 37)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; skeletal muscle fiber development [GO:0048741]	alpha-galactosidase activity [GO:0004557]	endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]	GO:0004557; GO:0005789; GO:0005975; GO:0031965; GO:0043568; GO:0048741; GO:0051897
GN002775	GN002775.1	Q9UBQ7	46.2	312	313	328	1.21e-88	271	GRHPR_HUMAN	Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81)	Homo sapiens (Human)	dicarboxylic acid metabolic process [GO:0043648]; glyoxylate metabolic process [GO:0046487]	carboxylic acid binding [GO:0031406]; glyoxylate reductase (NADPH) activity [GO:0030267]; hydroxypyruvate reductase (NADH) activity [GO:0008465]; hydroxypyruvate reductase (NADPH) activity [GO:0120509]; hydroxypyruvate reductase [NAD(P)H] activity [GO:0016618]; NAD binding [GO:0051287]; NADPH binding [GO:0070402]; protein homodimerization activity [GO:0042803]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]	GO:0005737; GO:0005739; GO:0005782; GO:0005829; GO:0008465; GO:0016618; GO:0030267; GO:0031406; GO:0042803; GO:0043648; GO:0046487; GO:0051287; GO:0070062; GO:0070402; GO:0120509; GO:1902494
GN002776	GN002776.1	Q91Z53	32.9	328	319	328	1.21e-42	152	GRHPR_MOUSE	Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81)	Mus musculus (Mouse)	dicarboxylic acid metabolic process [GO:0043648]; glyoxylate metabolic process [GO:0046487]	carboxylic acid binding [GO:0031406]; glyoxylate reductase (NADPH) activity [GO:0030267]; hydroxypyruvate reductase (NADH) activity [GO:0008465]; hydroxypyruvate reductase (NADPH) activity [GO:0120509]; hydroxypyruvate reductase [NAD(P)H] activity [GO:0016618]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; NADPH binding [GO:0070402]; protein homodimerization activity [GO:0042803]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0008465; GO:0016618; GO:0030267; GO:0031406; GO:0042803; GO:0043648; GO:0046487; GO:0050661; GO:0051287; GO:0070402; GO:0120509; GO:1902494
GN002777	GN002777.1	Q9UBQ7	51.1	321	327	328	9.37e-110	325	GRHPR_HUMAN	Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81)	Homo sapiens (Human)	dicarboxylic acid metabolic process [GO:0043648]; glyoxylate metabolic process [GO:0046487]	carboxylic acid binding [GO:0031406]; glyoxylate reductase (NADPH) activity [GO:0030267]; hydroxypyruvate reductase (NADH) activity [GO:0008465]; hydroxypyruvate reductase (NADPH) activity [GO:0120509]; hydroxypyruvate reductase [NAD(P)H] activity [GO:0016618]; NAD binding [GO:0051287]; NADPH binding [GO:0070402]; protein homodimerization activity [GO:0042803]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]	GO:0005737; GO:0005739; GO:0005782; GO:0005829; GO:0008465; GO:0016618; GO:0030267; GO:0031406; GO:0042803; GO:0043648; GO:0046487; GO:0051287; GO:0070062; GO:0070402; GO:0120509; GO:1902494
GN002780	GN002780.1	O35375	33.3	111	138	931	2.86e-09	57.4	NRP2_MOUSE	Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2)	Mus musculus (Mouse)	angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cellular response to leukemia inhibitory factor [GO:1990830]; dorsal root ganglion morphogenesis [GO:1904835]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; heart development [GO:0007507]; negative chemotaxis [GO:0050919]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; outflow tract septum morphogenesis [GO:0003148]; regulation of postsynapse organization [GO:0099175]; semaphorin-plexin signaling pathway [GO:0071526]; sensory neuron axon guidance [GO:0097374]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; ventral trunk neural crest cell migration [GO:0036486]; vestibulocochlear nerve structural organization [GO:0021649]	identical protein binding [GO:0042802]; semaphorin receptor activity [GO:0017154]; vascular endothelial growth factor receptor activity [GO:0005021]	axon [GO:0030424]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0001525; GO:0001755; GO:0001764; GO:0003148; GO:0005021; GO:0005576; GO:0005886; GO:0007411; GO:0007507; GO:0016020; GO:0017154; GO:0021612; GO:0021649; GO:0021675; GO:0021828; GO:0030424; GO:0036486; GO:0042802; GO:0045211; GO:0048846; GO:0050919; GO:0061549; GO:0061551; GO:0071526; GO:0097374; GO:0097490; GO:0097491; GO:0098978; GO:0099175; GO:1901166; GO:1903375; GO:1904835; GO:1990830
GN002784	GN002784.1	A4VCH0	46.9	524	466	586	1.81e-160	469	SAC1A_DANRE	Phosphatidylinositol-3-phosphatase SAC1-A (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Suppressor of actin mutations 1-like protein A)	Danio rerio (Zebrafish) (Brachydanio rerio)	phosphatidylinositol dephosphorylation [GO:0046856]	phosphatase activity [GO:0016791]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; Golgi membrane [GO:0000139]	GO:0000139; GO:0004438; GO:0005789; GO:0016791; GO:0043812; GO:0046856; GO:0140268
GN002785	GN002785.1	Q99MS3	36.7	150	164	194	2.45e-26	101	MP17L_MOUSE	Mpv17-like protein (M-LP)	Mus musculus (Mouse)	negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; reactive oxygen species metabolic process [GO:0072593]		cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0005737; GO:0005739; GO:0005777; GO:0005778; GO:0010730; GO:0072593; GO:1901029
GN002786	GN002786.1	Q4L208	58.5	521	627	575	3.61e-195	563	SL9A8_RAT	Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8)	Rattus norvegicus (Rat)	acrosome assembly [GO:0001675]; Golgi lumen acidification [GO:0061795]; potassium ion transport [GO:0006813]; proton transmembrane transport [GO:1902600]; regulation of intracellular pH [GO:0051453]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; multivesicular body membrane [GO:0032585]; trans-Golgi network membrane [GO:0032588]	GO:0000139; GO:0001669; GO:0001675; GO:0005794; GO:0006813; GO:0006814; GO:0015385; GO:0015386; GO:0016324; GO:0032585; GO:0032588; GO:0035725; GO:0051453; GO:0061795; GO:1902600
GN002787	GN002787.1	Q6IND4	39.9	557	586	556	2.06e-122	375	EEPD1_XENLA	Endonuclease/exonuclease/phosphatase family domain-containing protein 1	Xenopus laevis (African clawed frog)	DNA repair [GO:0006281]	catalytic activity [GO:0003824]; DNA binding [GO:0003677]	plasma membrane [GO:0005886]	GO:0003677; GO:0003824; GO:0005886; GO:0006281
GN002788	GN002788.1	P70031	22.6	349	376	453	1.19e-13	75.5	CCKAR_XENLA	Cholecystokinin receptor (CCK-XLR)	Xenopus laevis (African clawed frog)	neuropeptide signaling pathway [GO:0007218]	neuropeptide receptor activity [GO:0008188]	plasma membrane [GO:0005886]	GO:0005886; GO:0007218; GO:0008188
GN002789	GN002789.1	A2VEC9	28.0	2051	2069	5150	1.81e-170	587	SSPO_HUMAN	SCO-spondin (SCO-spondin pseudogene)	Homo sapiens (Human)		extracellular matrix structural constituent [GO:0005201]; peptidase inhibitor activity [GO:0030414]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005201; GO:0005576; GO:0030414; GO:0031012
GN002791	GN002791.1	Q5M834	36.8	171	329	352	3.92e-22	98.6	DTBP1_RAT	Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1)	Rattus norvegicus (Rat)	actin cytoskeleton organization [GO:0030036]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; axo-dendritic protein transport [GO:0099640]; blood coagulation [GO:0007596]; cilium assembly [GO:0060271]; dendrite morphogenesis [GO:0048813]; gene expression [GO:0010467]; intracellular protein localization [GO:0008104]; kidney development [GO:0001822]; memory [GO:0007613]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; platelet dense granule organization [GO:0060155]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; protein localization to ciliary membrane [GO:1903441]; protein transmembrane transport [GO:0071806]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of dopamine secretion [GO:0014059]; regulation of JUN kinase activity [GO:0043506]; regulation of signal transduction [GO:0009966]; regulation of synaptic vesicle exocytosis [GO:2000300]; retina development in camera-type eye [GO:0060041]	AP-3 adaptor complex binding [GO:0035651]	axon [GO:0030424]; axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cell body [GO:0044297]; clathrin-sculpted vesicle [GO:0060198]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; melanosome membrane [GO:0033162]; microtubule cytoskeleton [GO:0015630]; microvesicle [GO:1990742]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic membrane [GO:0042734]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle membrane [GO:0030672]	GO:0001822; GO:0001934; GO:0001956; GO:0002092; GO:0005634; GO:0005737; GO:0005789; GO:0005886; GO:0007596; GO:0007613; GO:0008089; GO:0008104; GO:0009966; GO:0010008; GO:0010467; GO:0010628; GO:0014059; GO:0014069; GO:0015630; GO:0016528; GO:0030036; GO:0030424; GO:0030426; GO:0030672; GO:0031083; GO:0031175; GO:0033162; GO:0035651; GO:0042383; GO:0042734; GO:0043005; GO:0043025; GO:0043197; GO:0043506; GO:0044297; GO:0044306; GO:0048490; GO:0048812; GO:0048813; GO:0060041; GO:0060155; GO:0060159; GO:0060198; GO:0060271; GO:0061002; GO:0061646; GO:0071806; GO:0071901; GO:0098685; GO:0098686; GO:0098978; GO:0099640; GO:1903441; GO:1904115; GO:1990742; GO:2000300
GN002793	GN002793.1	Q1LXS2	39.8	254	255	260	1.69e-67	212	PSMG2_DANRE	Proteasome assembly chaperone 2 (Tumor necrosis factor superfamily member 5-induced protein 1 homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	chaperone-mediated protein complex assembly [GO:0051131]; proteasome assembly [GO:0043248]	molecular adaptor activity [GO:0060090]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0043248; GO:0051131; GO:0060090
GN002794	GN002794.1	Q8TEX9	37.7	1091	1086	1081	5.57e-219	659	IPO4_HUMAN	Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)	Homo sapiens (Human)	protein import into nucleus [GO:0006606]; protein localization to nucleus [GO:0034504]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000785; GO:0005634; GO:0005737; GO:0006606; GO:0008139; GO:0016020; GO:0031267; GO:0032991; GO:0034504; GO:0061608
GN002795	GN002795.1	Q9CWZ7	38.2	296	292	312	9.05e-59	193	SNAG_MOUSE	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein gamma)	Mus musculus (Mouse)	intracellular protein transport [GO:0006886]	soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; synapse [GO:0045202]	GO:0005483; GO:0005739; GO:0005794; GO:0005886; GO:0006886; GO:0016020; GO:0019905; GO:0031201; GO:0043209; GO:0045202
GN002796	GN002796.1	C6EUD4	55.0	469	467	478	4.02e-174	500	APSCT_FASHE	Succinyl-CoA:acetate/propanoyl-CoA:succinate CoA transferase (EC 2.8.3.18) (EC 2.8.3.27) (Acetate:succinate CoA-transferase) (ASCT) (Propionate:succinate CoA-transferase) (PSCT) (Short-chain acyl-CoA-transferase)	Fasciola hepatica (Liver fluke)	acetate metabolic process [GO:0006083]	acetate CoA-transferase activity [GO:0008775]; propionyl-CoA:succinate CoA-transferase activity [GO:0043821]	mitochondrion [GO:0005739]	GO:0005739; GO:0006083; GO:0008775; GO:0043821
GN002797	GN002797.1	Q9ULX7	36.9	295	310	337	2.62e-53	180	CAH14_HUMAN	Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV)	Homo sapiens (Human)		carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004089; GO:0005886; GO:0008270; GO:0016020; GO:0016323; GO:0016324
GN002798	GN002798.1	Q6AZB8	31.2	189	257	349	7.52e-20	90.5	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN002799	GN002799.1	Q6AZB8	32.5	228	288	349	1.17e-36	136	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN002800	GN002800.1	Q9CR78	29.0	100	179	275	9.56e-09	56.6	MSD3_MOUSE	Myb/SANT-like DNA-binding domain-containing protein 3	Mus musculus (Mouse)				
GN002803	GN002803.1	P0DUE1	31.1	167	222	415	4.89e-12	67.8	STING_MAGGI	Stimulator of interferon genes protein (TIR-STING) (Probable NAD(+) hydrolase) (EC 3.2.2.6)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	activation of innate immune response [GO:0002218]; autophagosome assembly [GO:0000045]; innate immune response [GO:0045087]; positive regulation of macroautophagy [GO:0016239]; positive regulation of type I interferon production [GO:0032481]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; NAD+ nucleosidase activity, cyclic ADP-ribose generating [GO:0061809]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]	GO:0000045; GO:0002218; GO:0005776; GO:0005789; GO:0007165; GO:0016239; GO:0032481; GO:0035438; GO:0045087; GO:0061507; GO:0061709; GO:0061809
GN002807	GN002807.1	G5CTG2	49.5	188	192	277	2.03e-52	172	AQP5_MILTA	Aquaporin-5 (AQP-5)	Milnesium tardigradum (Water bear) (Tardigrade)		water channel activity [GO:0015250]	plasma membrane [GO:0005886]	GO:0005886; GO:0015250
GN002808	GN002808.1	P18293	64.5	166	172	1057	2.34e-67	224	ANPRA_MOUSE	Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)	Mus musculus (Mouse)	cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	ANPR-A receptor complex [GO:1990620]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005789; GO:0005886; GO:0006182; GO:0007166; GO:0007168; GO:0008217; GO:0016020; GO:0016941; GO:0017046; GO:0031965; GO:0035556; GO:0042417; GO:0042562; GO:0043114; GO:0043235; GO:0048662; GO:1990620
GN002812	GN002812.1	P22892	59.9	860	824	822	0.0	964	AP1G1_MOUSE	AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin adaptor protein 1 core) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma-adaptin) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1)	Mus musculus (Mouse)	basolateral protein secretion [GO:0110010]; endosome to melanosome transport [GO:0035646]; Golgi to lysosome transport [GO:0090160]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192]	clathrin-cargo adaptor activity [GO:0035615]; collagen binding [GO:0005518]; GTP-dependent protein binding [GO:0030742]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267]	AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	GO:0005518; GO:0005737; GO:0005765; GO:0005769; GO:0005794; GO:0005802; GO:0005829; GO:0005905; GO:0006886; GO:0006896; GO:0016182; GO:0016192; GO:0019894; GO:0030121; GO:0030136; GO:0030742; GO:0031267; GO:0032588; GO:0035615; GO:0035646; GO:0043323; GO:0045954; GO:0048471; GO:0048488; GO:0055037; GO:0060155; GO:0090160; GO:0098793; GO:0110010; GO:1903232
GN002813	GN002813.1	Q8R516	35.4	899	859	973	4.19e-85	295	MIB2_MOUSE	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Dystrophin-like protein) (Dyslike) (Mind bomb homolog 2) (Mind bomb-2) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin)	Mus musculus (Mouse)	protein ubiquitination [GO:0016567]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation protein catabolic process at postsynapse [GO:0140252]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0004842; GO:0005737; GO:0005769; GO:0005886; GO:0008270; GO:0016567; GO:0061630; GO:0098794; GO:0098978; GO:0099149; GO:0140252
GN002814	GN002814.1	A6QLQ8	41.1	151	147	413	2.54e-34	126	ENDOU_BOVIN	Uridylate-specific endoribonuclease (EC 3.1.-.-) (EC 4.6.1.-) (Protein endoU)	Bos taurus (Bovine)	immune response [GO:0006955]	polysaccharide binding [GO:0030247]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; scavenger receptor activity [GO:0005044]	extracellular region [GO:0005576]	GO:0003723; GO:0004521; GO:0005044; GO:0005576; GO:0006955; GO:0030247
GN002815	GN002815.1	Q5M8N4	47.9	188	196	293	3.96e-57	184	D39U1_MOUSE	Epimerase family protein SDR39U1 (EC 1.1.1.-) (Short-chain dehydrogenase/reductase family 39U member 1)	Mus musculus (Mouse)				
GN002816	GN002816.1	Q9J4Z4	28.7	223	433	592	2.23e-10	66.2	V246_FOWPN	Putative ankyrin repeat protein FPV246	Fowlpox virus (strain NVSL) (FPV)				
GN002818	GN002818.1	Q66IJ4	56.6	389	408	419	1.35e-142	415	PIGM_XENTR	GPI alpha-1,4-mannosyltransferase I, catalytic subunit (EC 2.4.1.-) (GPI mannosyltransferase I) (GPI-MT-I) (Phosphatidylinositol-glycan biosynthesis class M protein) (PIG-M)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	GPI anchor biosynthetic process [GO:0006506]	dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity [GO:0180041]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-mannosyltransferase I complex [GO:1990529]	GO:0000030; GO:0005789; GO:0006506; GO:0180041; GO:1990529
GN002819	GN002819.1	P82916	33.7	89	189	130	4.58e-13	66.2	RT17_BOVIN	Small ribosomal subunit protein uS17m (28S ribosomal protein S17, mitochondrial) (MRP-S17) (S17mt)	Bos taurus (Bovine)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005763; GO:0006412
GN002822	GN002822.1	O61585	53.4	698	833	690	4.55e-84	286	KTNB1_STRPU	Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin)	Strongylocentrotus purpuratus (Purple sea urchin)	microtubule depolymerization [GO:0007019]; microtubule severing [GO:0051013]	microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; katanin complex [GO:0008352]; spindle [GO:0005819]; spindle pole [GO:0000922]	GO:0000922; GO:0005737; GO:0005813; GO:0005819; GO:0007019; GO:0008017; GO:0008352; GO:0051013
GN002824	GN002824.1	Q3T0Q3	76.5	102	115	275	1.64e-52	169	RPB3_BOVIN	DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II subunit C)	Bos taurus (Bovine)	transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]	DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]	GO:0003677; GO:0003899; GO:0005634; GO:0005665; GO:0006366; GO:0006367; GO:0006368; GO:0008270; GO:0046983
GN002825	GN002825.1	Q0P5J9	44.8	290	503	312	2.97e-65	216	RPR1A_BOVIN	Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein)	Bos taurus (Bovine)	mRNA 3'-end processing [GO:0031124]; RNA polymerase II promoter clearance [GO:0001111]	identical protein binding [GO:0042802]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550]	GO:0000993; GO:0001111; GO:0005634; GO:0005654; GO:0031124; GO:0042802; GO:0097550; GO:0099122
GN002827	GN002827.1	Q5SSH8	46.0	226	279	263	8.93e-72	224	NEUFC_MOUSE	Neuferricin (Cytochrome b5 domain-containing protein 2)	Mus musculus (Mouse)	positive regulation of neuron differentiation [GO:0045666]	heme binding [GO:0020037]	extracellular region [GO:0005576]	GO:0005576; GO:0020037; GO:0045666
GN002828	GN002828.1	A6NMZ7	23.2	194	1021	2263	3.54e-09	65.1	CO6A6_HUMAN	Collagen alpha-6(VI) chain	Homo sapiens (Human)	extracellular matrix organization [GO:0030198]		collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005589; GO:0030198; GO:0031012
GN002829	GN002829.1	Q5M8L8	45.2	186	270	230	5.84e-45	154	HVCN1_XENTR	Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; proton transmembrane transport [GO:1902600]	voltage-gated proton channel activity [GO:0030171]	plasma membrane [GO:0005886]	GO:0005886; GO:0030171; GO:0071294; GO:0071467; GO:1902600
GN002830	GN002830.1	Q8TEP8	29.5	1205	2663	2537	6.45e-133	472	CE192_HUMAN	Centrosomal protein of 192 kDa (Cep192) (Cep192/SPD-2)	Homo sapiens (Human)	centriole replication [GO:0007099]; centrosome cycle [GO:0007098]; centrosome-templated microtubule nucleation [GO:0090222]; mitotic spindle assembly [GO:0090307]; protein localization to centrosome [GO:0071539]	phosphatase binding [GO:0019902]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; pericentriolar material [GO:0000242]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099]	GO:0000242; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0007098; GO:0007099; GO:0019902; GO:0036064; GO:0071539; GO:0090222; GO:0090307; GO:0120098; GO:0120099
GN002831	GN002831.1	Q7ZXF1	37.4	1103	1064	1078	6.34e-217	653	MTMR4_XENLA	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase)	Xenopus laevis (African clawed frog)	glycerophospholipid biosynthetic process [GO:0046474]; midbody abscission [GO:0061952]; negative regulation of endocytic recycling [GO:2001136]; phagosome maturation [GO:0090382]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of autophagy [GO:0010506]	metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; early phagosome membrane [GO:0036186]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038]	GO:0004438; GO:0004722; GO:0005829; GO:0010008; GO:0010506; GO:0016020; GO:0019903; GO:0031901; GO:0031902; GO:0036186; GO:0046474; GO:0046856; GO:0046872; GO:0052629; GO:0055038; GO:0060090; GO:0061952; GO:0090382; GO:2001136
GN002842	GN002842.1	Q0E908	27.2	489	927	818	7.89e-39	159	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN002845	GN002845.1	Q20929	30.4	283	385	510	1.32e-21	99.8	DMSR1_CAEEL	G protein-coupled receptor dmsr-1 (Dromyosuppressin receptor related 1)	Caenorhabditis elegans	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of cellular response to heat [GO:1900034]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008188; GO:0008528; GO:0032809; GO:0045187; GO:1900034
GN002846	GN002846.1	Q20929	30.4	283	385	510	1.32e-21	99.8	DMSR1_CAEEL	G protein-coupled receptor dmsr-1 (Dromyosuppressin receptor related 1)	Caenorhabditis elegans	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of cellular response to heat [GO:1900034]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008188; GO:0008528; GO:0032809; GO:0045187; GO:1900034
GN002848	GN002848.1	Q5ZHX9	67.2	384	446	409	1.09e-190	538	DPH1_CHICK	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)	Gallus gallus (Chicken)	protein histidyl modification to diphthamide [GO:0017183]	2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560]; 4 iron, 4 sulfur cluster binding [GO:0051539]	2-(3-amino-3-carboxypropyl)histidine synthase complex [GO:0120513]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0017183; GO:0051539; GO:0090560; GO:0120513
GN002849	GN002849.1	Q5ZII9	49.8	824	818	827	9.40e-294	832	TFP11_CHICK	Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1)	Gallus gallus (Chicken)	negative regulation of protein-containing complex assembly [GO:0031333]; spliceosomal complex disassembly [GO:0000390]	nucleic acid binding [GO:0003676]	catalytic step 2 spliceosome [GO:0071013]; chromosome, telomeric region [GO:0000781]; extracellular matrix [GO:0031012]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; spliceosomal complex [GO:0005681]; U2-type post-mRNA release spliceosomal complex [GO:0071008]	GO:0000390; GO:0000781; GO:0003676; GO:0005681; GO:0005730; GO:0016607; GO:0031012; GO:0031333; GO:0071008; GO:0071013
GN002850	GN002850.1	F1R520	36.5	921	958	954	2.75e-172	530	CSTN1_DANRE	Calsyntenin-1	Danio rerio (Zebrafish) (Brachydanio rerio)	axon arborization [GO:0140060]; axonal transport [GO:0098930]; endocytic recycling [GO:0032456]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; homophilic cell-cell adhesion [GO:0007156]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; regulation of collateral sprouting [GO:0048670]	calcium ion binding [GO:0005509]; cell-cell adhesion mediator activity [GO:0098632]	axon [GO:0030424]; cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]	GO:0000139; GO:0005509; GO:0005789; GO:0007156; GO:0009986; GO:0030424; GO:0030951; GO:0032456; GO:0045211; GO:0048670; GO:0050806; GO:0051965; GO:0098632; GO:0098839; GO:0098930; GO:0140060
GN002854	GN002854.1	Q7SY23	57.9	542	543	556	1.62e-234	659	AL4A1_DANRE	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)	Danio rerio (Zebrafish) (Brachydanio rerio)		L-glutamate gamma-semialdehyde dehydrogenase activity [GO:0003842]	mitochondrial matrix [GO:0005759]	GO:0003842; GO:0005759
GN002856	GN002856.1	O75934	69.0	187	191	225	1.54e-85	254	SPF27_HUMAN	Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27)	Homo sapiens (Human)	mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]		catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000375; GO:0000398; GO:0000974; GO:0005634; GO:0005654; GO:0005681; GO:0005730; GO:0008380; GO:0016607; GO:0071006; GO:0071007; GO:0071013; GO:0071014; GO:0071020
GN002857	GN002857.1	Q6GVH4	48.2	691	624	698	1.47e-176	520	GGNB2_CHICK	Gametogenetin-binding protein 2 (Protein ZNF403)	Gallus gallus (Chicken)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN002858	GN002858.1	O96006	31.0	213	248	694	4.13e-20	92.4	ZBED1_HUMAN	E3 SUMO-protein ligase ZBED1 (EC 2.3.2.-) (DNA replication-related element-binding factor) (Putative Ac-like transposable element) (Zinc finger BED domain-containing protein 1) (dREF homolog)	Homo sapiens (Human)	host-mediated suppression of viral genome replication [GO:0044828]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autosumoylation [GO:1990466]; protein sumoylation [GO:0016925]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0003712; GO:0003713; GO:0005634; GO:0005654; GO:0006355; GO:0006357; GO:0016605; GO:0016925; GO:0019789; GO:0031965; GO:0042802; GO:0043565; GO:0044828; GO:0045944; GO:0046983; GO:0061665; GO:1990466; GO:1990837
GN002860	GN002860.1	Q9UK58	65.4	338	463	526	8.41e-146	429	CCNL1_HUMAN	Cyclin-L1 (Cyclin-L)	Homo sapiens (Human)	regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of centrosome cycle [GO:0046605]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin L-CDK11 complex [GO:0180038]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000307; GO:0005634; GO:0005654; GO:0006357; GO:0016538; GO:0016604; GO:0016607; GO:0042981; GO:0043484; GO:0046605; GO:0048024; GO:0051726; GO:0180038
GN002861	GN002861.1	Q7ZUC2	38.2	327	329	356	1.08e-66	216	CAB45_DANRE	45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4)	Danio rerio (Zebrafish) (Brachydanio rerio)	calcium-ion regulated exocytosis [GO:0017156]; sprouting angiogenesis [GO:0002040]	calcium ion binding [GO:0005509]	endoplasmic reticulum [GO:0005783]; Golgi lumen [GO:0005796]	GO:0002040; GO:0005509; GO:0005783; GO:0005796; GO:0017156
GN002862	GN002862.1	A0A0G2K344	54.3	1066	1055	1068	0.0	1174	PK3CA_RAT	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)	Rattus norvegicus (Rat)	actin cytoskeleton organization [GO:0030036]; adipose tissue development [GO:0060612]; autosome genomic imprinting [GO:0141068]; cardiac muscle cell contraction [GO:0086003]; cell migration [GO:0016477]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to insulin stimulus [GO:0032869]; energy homeostasis [GO:0097009]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; liver development [GO:0001889]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of anoikis [GO:2000811]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of actin filament organization [GO:0110053]; regulation of cellular respiration [GO:0043457]; regulation of gene expression [GO:0010468]; regulation of multicellular organism growth [GO:0040014]; regulation of protein phosphorylation [GO:0001932]; relaxation of cardiac muscle [GO:0055119]; response to activity [GO:0014823]; response to butyrate [GO:1903544]; response to dexamethasone [GO:0071548]; response to L-leucine [GO:0043201]; response to muscle inactivity [GO:0014870]; response to muscle stretch [GO:0035994]; TORC2 signaling [GO:0038203]; vascular endothelial growth factor signaling pathway [GO:0038084]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; insulin receptor substrate binding [GO:0043560]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]	GO:0001889; GO:0001932; GO:0004674; GO:0005829; GO:0005886; GO:0005942; GO:0005943; GO:0005944; GO:0006006; GO:0008286; GO:0010468; GO:0010629; GO:0014704; GO:0014823; GO:0014870; GO:0016303; GO:0016477; GO:0030027; GO:0030036; GO:0030295; GO:0030835; GO:0032869; GO:0035005; GO:0035994; GO:0036092; GO:0038084; GO:0038203; GO:0040014; GO:0043201; GO:0043457; GO:0043491; GO:0043524; GO:0043560; GO:0045860; GO:0046854; GO:0046934; GO:0048009; GO:0048015; GO:0048661; GO:0051897; GO:0055119; GO:0060612; GO:0071333; GO:0071464; GO:0071548; GO:0086003; GO:0097009; GO:0106310; GO:0110053; GO:0141068; GO:1903544; GO:1905477; GO:2000270; GO:2000811
GN002863	GN002863.1	O08781	29.9	298	912	289	4.48e-25	109	ZMAT3_RAT	Zinc finger matrin-type protein 3 (Zinc finger protein WIG-1) (p53-activated gene 608 protein)	Rattus norvegicus (Rat)	positive regulation of apoptotic process [GO:0043065]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003676; GO:0005634; GO:0005654; GO:0005730; GO:0008270; GO:0043065
GN002866	GN002866.1	P48065	42.5	574	623	614	2.00e-160	476	S6A12_HUMAN	Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12)	Homo sapiens (Human)	amino acid transport [GO:0006865]; gamma-aminobutyric acid reuptake [GO:0051936]; gamma-aminobutyric acid transport [GO:0015812]; glycine betaine transport [GO:0031460]; monocarboxylic acid transport [GO:0015718]; sodium ion transmembrane transport [GO:0035725]	amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; glycine betaine:sodium:chloride symporter activity [GO:0140814]; monocarboxylic acid transmembrane transporter activity [GO:0008028]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0005332; GO:0005886; GO:0006865; GO:0008028; GO:0015171; GO:0015718; GO:0015812; GO:0016020; GO:0016323; GO:0031460; GO:0035725; GO:0051936; GO:0098793; GO:0140814
GN002871	GN002871.1	Q6DDP3	36.5	414	443	441	7.75e-91	285	ENPP6_XENLA	Glycerophosphocholine cholinephosphodiesterase ENPP6 (GPC-Cpde) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) (E-NPP 6) (NPP-6)	Xenopus laevis (African clawed frog)	choline metabolic process [GO:0019695]; lipid metabolic process [GO:0006629]	glycerophosphocholine cholinephosphodiesterase activity [GO:0047390]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; phosphoric diester hydrolase activity [GO:0008081]	plasma membrane [GO:0005886]	GO:0005886; GO:0006629; GO:0008081; GO:0008889; GO:0019695; GO:0047390
GN002876	GN002876.1	Q5BKW7	39.5	296	314	438	3.08e-82	258	ENPP6_DANRE	Glycerophosphocholine cholinephosphodiesterase ENPP6 (GPC-Cpde) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) (E-NPP 6) (NPP-6)	Danio rerio (Zebrafish) (Brachydanio rerio)	choline metabolic process [GO:0019695]; lipid metabolic process [GO:0006629]	glycerophosphocholine cholinephosphodiesterase activity [GO:0047390]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; phosphoric diester hydrolase activity [GO:0008081]	plasma membrane [GO:0005886]	GO:0005886; GO:0006629; GO:0008081; GO:0008889; GO:0019695; GO:0047390
GN002877	GN002877.1	Q86YT5	39.9	537	512	568	6.11e-119	364	S13A5_HUMAN	Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5)	Homo sapiens (Human)	alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; citrate transport [GO:0015746]; fumarate transport [GO:0015741]; oxaloacetate transport [GO:0015729]; succinate transport [GO:0015744]; transmembrane transport [GO:0055085]	citrate transmembrane transporter activity [GO:0015137]; identical protein binding [GO:0042802]; organic acid:sodium symporter activity [GO:0005343]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]	plasma membrane [GO:0005886]	GO:0005343; GO:0005886; GO:0015137; GO:0015141; GO:0015729; GO:0015741; GO:0015742; GO:0015744; GO:0015746; GO:0017153; GO:0042802; GO:0055085; GO:0071285
GN002879	GN002879.1	Q8N8K9	25.8	221	272	716	2.09e-11	67.4	K1958_HUMAN	Uncharacterized protein KIAA1958	Homo sapiens (Human)				
GN002881	GN002881.1	O95395	44.0	275	327	438	1.88e-68	223	GCNT3_HUMAN	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (hC2GnT-M) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase) (C2/4GnT)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via N-acetyl-galactosamine [GO:0016266]	acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0047225]; acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0003829; GO:0005975; GO:0006493; GO:0008109; GO:0008375; GO:0016020; GO:0016266; GO:0047225; GO:0070062
GN002883	GN002883.1	D3YZI9	32.2	121	251	523	6.73e-09	59.3	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN002886	GN002886.1	Q60803	36.9	141	146	567	1.24e-25	104	TRAF3_MOUSE	TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (RING-type E3 ubiquitin transferase TRAF3)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cell surface receptor signaling pathway [GO:0007166]; mRNA transcription [GO:0009299]; positive regulation of type I interferon production [GO:0032481]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; endosome [GO:0005768]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]	GO:0001817; GO:0002224; GO:0004842; GO:0005164; GO:0005737; GO:0005739; GO:0005768; GO:0007166; GO:0008063; GO:0008270; GO:0009299; GO:0009898; GO:0010008; GO:0019901; GO:0019903; GO:0030162; GO:0031625; GO:0031996; GO:0032481; GO:0032648; GO:0033209; GO:0034142; GO:0035591; GO:0035631; GO:0042802; GO:0042981; GO:0043122; GO:0050688; GO:0061630; GO:0140374
GN002888	GN002888.1	Q9VZW5	28.1	302	398	549	9.31e-18	88.6	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN002890	GN002890.1	Q9N1Q0	78.7	141	169	240	1.55e-63	198	RSMB_NOTEU	Small nuclear ribonucleoprotein-associated protein B' (snRNP-B') (snRPB') (Sm protein B') (Sm-B') (SmB')	Notamacropus eugenii (Tammar wallaby) (Macropus eugenii)	mRNA splicing, via spliceosome [GO:0000398]; spliceosomal snRNP assembly [GO:0000387]	RNA binding [GO:0003723]	cytosol [GO:0005829]; methylosome [GO:0034709]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; SMN-Sm protein complex [GO:0034719]; U1 snRNP [GO:0005685]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U7 snRNP [GO:0005683]	GO:0000387; GO:0000398; GO:0003723; GO:0005634; GO:0005683; GO:0005684; GO:0005685; GO:0005687; GO:0005829; GO:0016607; GO:0034709; GO:0034719; GO:0046540; GO:0071005; GO:0071007
GN002895	GN002895.1	Q9R1R2	26.9	245	660	744	4.48e-16	85.9	TRIM3_MOUSE	Tripartite motif-containing protein 3 (EC 2.3.2.27) (RING finger protein 22) (RING finger protein HAC1)	Mus musculus (Mouse)	neural precursor cell proliferation [GO:0061351]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]; toll-like receptor signaling pathway [GO:0002224]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; postsynapse [GO:0098794]	GO:0000209; GO:0002224; GO:0004842; GO:0005737; GO:0005769; GO:0005794; GO:0008270; GO:0016567; GO:0030425; GO:0034141; GO:0042802; GO:0043161; GO:0061351; GO:0061630; GO:0070534; GO:0098794; GO:0098978; GO:0140252
GN002896	GN002896.1	A2AIL4	40.2	311	322	333	3.17e-70	224	NDUF6_MOUSE	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6	Mus musculus (Mouse)	mitochondrial respiratory chain complex I assembly [GO:0032981]		cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0005743; GO:0032981
GN002899	GN002899.1	Q8NCN5	46.9	861	896	879	4.08e-269	774	PDPR_HUMAN	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr)	Homo sapiens (Human)	positive regulation of pyruvate decarboxylation to acetyl-CoA [GO:0140176]		cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase (lipoamide) phosphatase complex [GO:0045253]	GO:0005737; GO:0005739; GO:0005759; GO:0045253; GO:0140176
GN002900	GN002900.1	Q05AK5	41.3	436	438	464	2.62e-111	338	MYLIB_DANRE	E3 ubiquitin-protein ligase MYLIP-B (EC 2.3.2.27) (Myosin regulatory light chain-interacting protein B) (MIR-B) (RING-type E3 ubiquitin transferase MYLIP-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	gastrulation [GO:0007369]; negative regulation of Wnt signaling pathway [GO:0030178]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004842; GO:0005737; GO:0005829; GO:0006511; GO:0007369; GO:0016567; GO:0030178; GO:0061630
GN002901	GN002901.1	Q60779	58.6	485	486	478	1.31e-167	484	DRC4_MOUSE	Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8)	Mus musculus (Mouse)	axoneme assembly [GO:0035082]; brain development [GO:0007420]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; intracellular protein localization [GO:0008104]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to cilium [GO:0061512]	microtubule binding [GO:0008017]; small GTPase binding [GO:0031267]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; sperm end piece [GO:0097229]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0000226; GO:0003351; GO:0005576; GO:0005737; GO:0005794; GO:0005829; GO:0005874; GO:0005886; GO:0005929; GO:0005930; GO:0007368; GO:0007420; GO:0008017; GO:0008104; GO:0015630; GO:0030317; GO:0031267; GO:0031514; GO:0035082; GO:0036064; GO:0036126; GO:0045880; GO:0061512; GO:0097225; GO:0097228; GO:0097229; GO:0097729; GO:1903566
GN002902	GN002902.1	P12394	35.7	451	445	508	6.66e-72	238	CP17A_CHICK	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)	Gallus gallus (Chicken)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; response to antibiotic [GO:0046677]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxygen binding [GO:0019825]; steroid 17-alpha-monooxygenase activity [GO:0004508]	membrane [GO:0016020]	GO:0004508; GO:0005506; GO:0006694; GO:0006805; GO:0008202; GO:0016020; GO:0019825; GO:0020037; GO:0042446; GO:0042448; GO:0046677
GN002905	GN002905.1	Q16698	67.8	183	224	335	9.00e-79	242	DECR_HUMAN	2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1)	Homo sapiens (Human)	fatty acid beta-oxidation [GO:0006635]; positive regulation of cold-induced thermogenesis [GO:0120162]	2,4-dienoyl-CoA reductase (NADPH) activity [GO:0008670]; identical protein binding [GO:0042802]; NADPH binding [GO:0070402]	catalytic complex [GO:1902494]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005739; GO:0005759; GO:0006635; GO:0008670; GO:0042802; GO:0070402; GO:0120162; GO:1902494
GN002907	GN002907.1	P08289	49.9	495	490	524	4.27e-150	441	PPBT_RAT	Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1)	Rattus norvegicus (Rat)	bone mineralization [GO:0030282]; calcium ion homeostasis [GO:0055074]; cementum mineralization [GO:0071529]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; futile creatine cycle [GO:0140651]; inhibition of non-skeletal tissue mineralization [GO:0140928]; phosphate ion homeostasis [GO:0055062]; positive regulation of cold-induced thermogenesis [GO:0120162]; pyridoxal 5'-phosphate metabolic process [GO:0042822]; response to antibiotic [GO:0046677]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to macrophage colony-stimulating factor [GO:0036005]; response to sodium phosphate [GO:1904383]; response to vitamin B6 [GO:0034516]; response to vitamin D [GO:0033280]	5'-nucleotidase activity [GO:0008253]; ADP phosphatase activity [GO:0043262]; alkaline phosphatase activity [GO:0004035]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; inorganic diphosphate phosphatase activity [GO:0004427]; phosphoamidase activity [GO:0050187]; phosphoethanolamine phosphatase activity [GO:0052732]; pyridoxal phosphatase activity [GO:0033883]; pyrophosphatase activity [GO:0016462]	extracellular matrix [GO:0031012]; extracellular membrane-bounded organelle [GO:0065010]; extracellular region [GO:0005576]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	GO:0001958; GO:0003006; GO:0004035; GO:0004427; GO:0005509; GO:0005576; GO:0005758; GO:0005886; GO:0008253; GO:0016462; GO:0016887; GO:0030282; GO:0031012; GO:0031966; GO:0032496; GO:0032868; GO:0033280; GO:0033883; GO:0034516; GO:0036005; GO:0042822; GO:0043262; GO:0046677; GO:0050187; GO:0051384; GO:0052732; GO:0055062; GO:0055074; GO:0065010; GO:0071529; GO:0120162; GO:0140651; GO:0140928; GO:1904383
GN002909	GN002909.1	Q6UWM7	50.6	348	367	567	7.47e-130	386	LCTL_HUMAN	Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; lens morphogenesis in camera-type eye [GO:0002089]	hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	brush border [GO:0005903]; endoplasmic reticulum membrane [GO:0005789]	GO:0002089; GO:0004553; GO:0005789; GO:0005903; GO:0005975
GN002910	GN002910.1	Q02401	28.1	1146	798	1928	7.27e-118	395	LPH_RAT	Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)]	Rattus norvegicus (Rat)	cellobiose catabolic process [GO:2000892]; glycosylceramide catabolic process [GO:0046477]; lactose catabolic process [GO:0005990]; quercetin catabolic process [GO:1901733]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to iron(II) ion [GO:0010040]; response to lead ion [GO:0010288]; response to nickel cation [GO:0010045]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to sucrose [GO:0009744]; response to xenobiotic stimulus [GO:0009410]	beta-glucosidase activity [GO:0008422]; cellobiose glucosidase activity [GO:0080079]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; lactase activity [GO:0000016]; phlorizin hydrolase activity [GO:0140749]; protein homodimerization activity [GO:0042803]; transferase activity [GO:0016740]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; external side of apical plasma membrane [GO:0098591]	GO:0000016; GO:0001666; GO:0004336; GO:0004348; GO:0005903; GO:0005990; GO:0007584; GO:0008422; GO:0009410; GO:0009725; GO:0009744; GO:0010040; GO:0010045; GO:0010288; GO:0016324; GO:0016740; GO:0042594; GO:0042803; GO:0043627; GO:0045471; GO:0046477; GO:0080079; GO:0098591; GO:0140749; GO:1901733; GO:2000892
GN002911	GN002911.1	W5PLZ6	61.2	165	191	1931	1.25e-66	224	LPH_SHEEP	Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)]	Ovis aries (Sheep)	cellobiose catabolic process [GO:2000892]; glycosylceramide catabolic process [GO:0046477]; lactose catabolic process [GO:0005990]; quercetin catabolic process [GO:1901733]	beta-glucosidase activity [GO:0008422]; cellobiose glucosidase activity [GO:0080079]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; lactase activity [GO:0000016]; phlorizin hydrolase activity [GO:0140749]	apical plasma membrane [GO:0016324]	GO:0000016; GO:0004336; GO:0004348; GO:0005990; GO:0008422; GO:0016324; GO:0046477; GO:0080079; GO:0140749; GO:1901733; GO:2000892
GN002912	GN002912.1	Q9SPP9	39.0	118	113	540	1.09e-13	68.9	RG1_RAUSE	Raucaffricine-O-beta-D-glucosidase (Raucaffricine beta-glucosidase) (RsRG) (EC 3.2.1.125) (Vomilenine glucosyltransferase) (RsVGT) (EC 2.4.1.219)	Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum)	alkaloid biosynthetic process [GO:0009821]; carbohydrate metabolic process [GO:0005975]	raucaffricine beta-glucosidase activity [GO:0050247]; vomilenine glucosyltransferase activity [GO:0050506]		GO:0005975; GO:0009821; GO:0050247; GO:0050506
GN002916	GN002916.1	Q3BCR8	33.8	231	223	245	8.55e-38	134	TPMT_PANTR	Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase)	Pan troglodytes (Chimpanzee)	xenobiotic metabolic process [GO:0006805]	S-adenosyl-L-methionine binding [GO:1904047]; thiopurine S-methyltransferase activity [GO:0008119]	cytoplasm [GO:0005737]	GO:0005737; GO:0006805; GO:0008119; GO:1904047
GN002917	GN002917.1	Q9VZW5	28.1	302	398	549	9.31e-18	88.6	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN002919	GN002919.1	B2GV54	36.0	356	345	408	6.86e-63	208	NCEH1_RAT	Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1)	Rattus norvegicus (Rat)	ether lipid metabolic process [GO:0046485]; protein dephosphorylation [GO:0006470]; xenobiotic metabolic process [GO:0006805]	acetylalkylglycerol acetylhydrolase activity [GO:0047378]; phosphate ion binding [GO:0042301]; serine hydrolase activity [GO:0017171]; sterol ester esterase activity [GO:0004771]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004771; GO:0005886; GO:0006470; GO:0006805; GO:0016020; GO:0017171; GO:0042301; GO:0046485; GO:0047378
GN002920	GN002920.1	O54750	39.3	473	488	501	1.05e-110	340	CP2J6_MOUSE	Cytochrome P450 2J6 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIJ6)	Mus musculus (Mouse)	epoxygenase P450 pathway [GO:0019373]; icosanoid metabolic process [GO:0006690]; linoleic acid metabolic process [GO:0043651]; xenobiotic metabolic process [GO:0006805]	arachidonate 11,12-epoxygenase activity [GO:0008405]; arachidonate 14,15-epoxygenase activity [GO:0008404]; arachidonate 5,6-epoxygenase activity [GO:0106301]; arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; isomerase activity [GO:0016853]; linoleic acid epoxygenase activity [GO:0071614]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005737; GO:0005783; GO:0005789; GO:0006690; GO:0006805; GO:0008392; GO:0008404; GO:0008405; GO:0016712; GO:0016853; GO:0019373; GO:0020037; GO:0043651; GO:0071614; GO:0106301
GN002923	GN002923.1	G9JJU2	49.7	159	222	172	8.42e-44	147	GPX_PROCL	Glutathione peroxidase (PcGPx) (Se-PcGPx) (EC 1.11.1.9)	Procambarus clarkii (Red swamp crayfish) (Cambarus clarkii)	response to oxidative stress [GO:0006979]	glutathione peroxidase activity [GO:0004602]		GO:0004602; GO:0006979
GN002924	GN002924.1	P91778	46.5	269	288	508	3.57e-73	236	AMY_PECMA	Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)	Pecten maximus (King scallop) (Pilgrim's clam)	carbohydrate metabolic process [GO:0005975]	alpha-amylase activity [GO:0004556]; cation binding [GO:0043169]		GO:0004556; GO:0005975; GO:0043169
GN002926	GN002926.1	P0DKY8	52.5	179	232	187	8.88e-55	176	NUD16_HOMVI	U8 snoRNA-decapping enzyme (EC 3.6.1.62) (IDP phosphatase) (IDPase) (EC 3.6.1.64) (Inosine diphosphate phosphatase) (Nucleoside diphosphate-linked moiety X motif 16) (Nudix motif 16) (m7GpppN-mRNA hydrolase)	Homalodisca vitripennis (Glassy-winged sharpshooter) (Homalodisca coagulata)	mRNA catabolic process [GO:0006402]; sno(s)RNA catabolic process [GO:0016077]	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; dIDP phosphatase activity [GO:0097383]; IDP phosphatase activity [GO:1990003]; phosphodiesterase decapping endonuclease activity [GO:1990174]; snoRNA binding [GO:0030515]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006402; GO:0016077; GO:0030515; GO:0097383; GO:0140933; GO:1990003; GO:1990174
GN002927	GN002927.1	P21158	38.4	164	247	166	6.83e-33	120	CSGA_MYXXA	C-signal (17-kDa C-factor protein) (p17) (C-factor) (Cell surface-associated intercellular C-signal)	Myxococcus xanthus		oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	cell outer membrane [GO:0009279]; extracellular region [GO:0005576]	GO:0005576; GO:0009279; GO:0016616
GN002935	GN002935.1	F1QR43	48.2	525	594	586	3.93e-170	499	GLCEB_DANRE	D-glucuronyl C5-epimerase B (EC 5.1.3.17)	Danio rerio (Zebrafish) (Brachydanio rerio)	heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin proteoglycan biosynthetic process [GO:0030210]	heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464]; identical protein binding [GO:0042802]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005794; GO:0015012; GO:0030210; GO:0042802; GO:0047464
GN002939	GN002939.1	Q9VXV9	46.6	204	290	317	4.19e-54	181	WCSD_DROME	WSCD family member CG9164	Drosophila melanogaster (Fruit fly)			membrane [GO:0016020]	GO:0016020
GN002940	GN002940.1	Q149M9	31.9	551	1233	1564	2.08e-65	247	NWD1_HUMAN	NACHT domain- and WD repeat-containing protein 1	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]		cytosol [GO:0005829]	GO:0005829; GO:0035556
GN002941	GN002941.1	Q6NRW5	56.5	214	220	303	5.90e-84	254	CDIN1_XENLA	CDAN1-interacting nuclease 1	Xenopus laevis (African clawed frog)	erythrocyte differentiation [GO:0030218]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0030218
GN002947	GN002947.1	Q8N0N3	50.6	354	552	366	7.35e-124	371	BGBP_PENMO	Beta-1,3-glucan-binding protein (GBP)	Penaeus monodon (Giant tiger prawn)	carbohydrate metabolic process [GO:0005975]; innate immune response [GO:0045087]	(1->3)-beta-D-glucan binding [GO:0001872]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	extracellular region [GO:0005576]	GO:0001872; GO:0004553; GO:0005576; GO:0005975; GO:0045087
GN002948	GN002948.1	Q5REG1	44.2	927	967	963	4.20e-209	625	SART3_PONAB	Spliceosome associated factor 3, U4/U6 recycling protein (Squamous cell carcinoma antigen recognized by T-cells 3) (SART-3)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	mRNA splicing, via spliceosome [GO:0000398]; nucleosome assembly [GO:0006334]; regulation of RNA metabolic process [GO:0051252]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]; transcription elongation-coupled chromatin remodeling [GO:0140673]	histone binding [GO:0042393]; protein-macromolecule adaptor activity [GO:0030674]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]; U6atac snRNA binding [GO:0030624]; ubiquitin-specific protease binding [GO:1990381]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 snRNP [GO:0071001]; U6atac snRNP [GO:0005691]	GO:0000244; GO:0000387; GO:0000398; GO:0005634; GO:0005654; GO:0005691; GO:0005737; GO:0006334; GO:0015030; GO:0016607; GO:0017070; GO:0030621; GO:0030624; GO:0030674; GO:0042393; GO:0051252; GO:0071001; GO:0140673; GO:1990381
GN002949	GN002949.1	Q5R8I8	51.8	309	361	409	3.10e-108	325	PISD_PONAB	Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain]	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	lipid droplet formation [GO:0140042]; mitochondrial protein catabolic process [GO:0035694]; phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540]; regulation of mitochondrion organization [GO:0010821]	phosphatidylserine decarboxylase activity [GO:0004609]	cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0004609; GO:0005737; GO:0005739; GO:0005743; GO:0005811; GO:0006646; GO:0010821; GO:0016540; GO:0035694; GO:0140042
GN002954	GN002954.1	P21127	77.0	395	796	795	3.67e-210	616	CD11B_HUMAN	Cyclin-dependent kinase 11B (EC 2.7.11.22) (EC 2.7.11.23) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)	Homo sapiens (Human)	apoptotic process [GO:0006915]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid cohesion, centromeric [GO:0071962]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of centrosome cycle [GO:0046605]; regulation of DNA-templated transcription [GO:0006355]; regulation of mRNA processing [GO:0050684]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA polymerase II promoter clearance [GO:0001111]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; RNA polymerase II CTD heptapeptide repeat S2 kinase activity [GO:0140834]; RNA polymerase II CTD heptapeptide repeat S5 kinase activity [GO:0140836]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cyclin L-CDK11 complex [GO:0180038]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0000278; GO:0000307; GO:0000775; GO:0001111; GO:0001558; GO:0003723; GO:0004672; GO:0004674; GO:0004693; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006355; GO:0006468; GO:0006915; GO:0008353; GO:0016607; GO:0042981; GO:0046605; GO:0048024; GO:0050684; GO:0051726; GO:0071962; GO:0106310; GO:0140834; GO:0140836; GO:0180038
GN002956	GN002956.1	Q5U367	43.1	385	451	741	1.06e-104	330	PLOD3_RAT	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]	Rattus norvegicus (Rat)	basement membrane assembly [GO:0070831]; cellular response to hormone stimulus [GO:0032870]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endothelial cell morphogenesis [GO:0001886]; epidermis morphogenesis [GO:0048730]; in utero embryonic development [GO:0001701]; intracellular protein localization [GO:0008104]; lung morphogenesis [GO:0060425]; neural tube development [GO:0021915]; peptidyl-lysine hydroxylation [GO:0017185]; protein O-linked glycosylation via galactose [GO:0180062]; vasodilation [GO:0042311]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; metal ion binding [GO:0046872]; procollagen galactosyltransferase activity [GO:0050211]; procollagen glucosyltransferase activity [GO:0033823]; procollagen-lysine 5-dioxygenase activity [GO:0008475]; small molecule binding [GO:0036094]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; rough endoplasmic reticulum [GO:0005791]; trans-Golgi network [GO:0005802]	GO:0001701; GO:0001886; GO:0005506; GO:0005576; GO:0005783; GO:0005788; GO:0005789; GO:0005791; GO:0005794; GO:0005802; GO:0008104; GO:0008475; GO:0017185; GO:0021915; GO:0030199; GO:0031012; GO:0031418; GO:0032870; GO:0032963; GO:0032964; GO:0033823; GO:0036094; GO:0042311; GO:0046872; GO:0048730; GO:0050211; GO:0060425; GO:0070831; GO:0180062
GN002957	GN002957.1	Q5U367	60.1	316	315	741	2.87e-149	439	PLOD3_RAT	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]	Rattus norvegicus (Rat)	basement membrane assembly [GO:0070831]; cellular response to hormone stimulus [GO:0032870]; collagen biosynthetic process [GO:0032964]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endothelial cell morphogenesis [GO:0001886]; epidermis morphogenesis [GO:0048730]; in utero embryonic development [GO:0001701]; intracellular protein localization [GO:0008104]; lung morphogenesis [GO:0060425]; neural tube development [GO:0021915]; peptidyl-lysine hydroxylation [GO:0017185]; protein O-linked glycosylation via galactose [GO:0180062]; vasodilation [GO:0042311]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; metal ion binding [GO:0046872]; procollagen galactosyltransferase activity [GO:0050211]; procollagen glucosyltransferase activity [GO:0033823]; procollagen-lysine 5-dioxygenase activity [GO:0008475]; small molecule binding [GO:0036094]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; rough endoplasmic reticulum [GO:0005791]; trans-Golgi network [GO:0005802]	GO:0001701; GO:0001886; GO:0005506; GO:0005576; GO:0005783; GO:0005788; GO:0005789; GO:0005791; GO:0005794; GO:0005802; GO:0008104; GO:0008475; GO:0017185; GO:0021915; GO:0030199; GO:0031012; GO:0031418; GO:0032870; GO:0032963; GO:0032964; GO:0033823; GO:0036094; GO:0042311; GO:0046872; GO:0048730; GO:0050211; GO:0060425; GO:0070831; GO:0180062
GN002958	GN002958.1	Q9GJW7	94.8	116	117	117	4.73e-76	223	GBRAP_BOVIN	Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein)	Bos taurus (Bovine)	autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; cellular response to nitrogen starvation [GO:0006995]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; mitophagy [GO:0000423]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of lysosome organization [GO:1905673]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Rac protein signal transduction [GO:0035020]; reticulophagy [GO:0061709]	beta-tubulin binding [GO:0048487]; GABA receptor binding [GO:0050811]; microtubule binding [GO:0008017]; phosphatidylethanolamine binding [GO:0008429]; protein sequestering activity [GO:0140311]; ubiquitin protein ligase binding [GO:0031625]	actin cytoskeleton [GO:0015629]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axoneme [GO:0005930]; cytoplasmic vesicle [GO:0031410]; endomembrane system [GO:0012505]; GABA-ergic synapse [GO:0098982]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; sperm midpiece [GO:0097225]	GO:0000045; GO:0000139; GO:0000421; GO:0000423; GO:0005764; GO:0005776; GO:0005790; GO:0005875; GO:0005886; GO:0005930; GO:0006995; GO:0008017; GO:0008429; GO:0008625; GO:0012505; GO:0015629; GO:0031410; GO:0031625; GO:0032436; GO:0035020; GO:0048487; GO:0050811; GO:0061709; GO:0097225; GO:0097352; GO:0098696; GO:0098982; GO:0140311; GO:1902524; GO:1904262; GO:1905673
GN002959	GN002959.1	Q28062	35.7	115	208	912	1.88e-12	68.9	PGCB_BOVIN	Brevican core protein	Bos taurus (Bovine)	cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; skeletal system development [GO:0001501]	hyaluronic acid binding [GO:0005540]	extracellular region [GO:0005576]; perineuronal net [GO:0072534]; synapse [GO:0045202]	GO:0001501; GO:0005540; GO:0005576; GO:0007155; GO:0007417; GO:0045202; GO:0072534
GN002960	GN002960.1	Q8WPD0	29.1	189	218	168	9.54e-13	67.0	LECG_PATPE	Alpha-N-acetylgalactosamine-specific lectin (Alpha-N-acetylgalactosamine-binding lectin) (GalNAc-specific lectin) (Lectin) (ApL) (Tn antigen-specific lectin)	Patiria pectinifera (Starfish) (Asterina pectinifera)				
GN002961	GN002961.1	P21941	24.5	335	379	496	1.36e-13	75.5	MATN1_HUMAN	Matrilin-1 (Cartilage matrix protein)	Homo sapiens (Human)	extracellular matrix organization [GO:0030198]; protein-containing complex assembly [GO:0065003]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216]; non-collagenous component of basement membrane [GO:0140144]	GO:0005201; GO:0005509; GO:0005576; GO:0030198; GO:0031012; GO:0065003; GO:0120216; GO:0140144
GN002962	GN002962.1	A6H584	26.9	346	582	2640	6.39e-15	82.4	CO6A5_MOUSE	Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain)	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]		collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005589; GO:0030198; GO:0031012
GN002971	GN002971.1	Q60847	30.3	142	184	3120	8.19e-11	63.5	COCA1_MOUSE	Collagen alpha-1(XII) chain	Mus musculus (Mouse)	endodermal cell differentiation [GO:0035987]		collagen type XII trimer [GO:0005595]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005595; GO:0031012; GO:0035987
GN002977	GN002977.1	A6H584	25.9	313	379	2640	1.04e-14	79.7	CO6A5_MOUSE	Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain)	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]		collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005589; GO:0030198; GO:0031012
GN002980	GN002980.1	O75376	37.8	598	2638	2440	3.46e-91	336	NCOR1_HUMAN	Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)	Homo sapiens (Human)	locomotor rhythm [GO:0045475]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glycolytic process [GO:0045820]; negative regulation of JNK cascade [GO:0046329]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; spindle assembly [GO:0051225]	histone deacetylase binding [GO:0042826]; nuclear receptor binding [GO:0016922]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	GO:0000118; GO:0000122; GO:0000785; GO:0000976; GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0016020; GO:0016922; GO:0017053; GO:0042826; GO:0045475; GO:0045820; GO:0045892; GO:0045922; GO:0046329; GO:0046966; GO:0051225; GO:0060633; GO:0060766; GO:0061629; GO:0072686; GO:1902894
GN002983	GN002983.1	O70583	28.3	523	631	680	1.62e-41	163	TRI18_MOUSE	E3 ubiquitin-protein ligase MID1 (EC 2.3.2.27) (Midin) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)	Mus musculus (Mouse)	negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein localization to microtubule [GO:0035372]; regulation of microtubule cytoskeleton organization [GO:0070507]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]	GO:0005737; GO:0005794; GO:0005829; GO:0005874; GO:0005881; GO:0007026; GO:0008017; GO:0008270; GO:0015630; GO:0019899; GO:0031625; GO:0032874; GO:0034451; GO:0035372; GO:0042802; GO:0042803; GO:0051219; GO:0061630; GO:0070507
GN002997	GN002997.1	Q6YHK3	24.5	1554	1560	1445	2.99e-101	360	CD109_HUMAN	CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)	Homo sapiens (Human)	negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]	endopeptidase inhibitor activity [GO:0004866]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	GO:0004866; GO:0005576; GO:0005886; GO:0009986; GO:0030512; GO:0031092; GO:0061045
GN002999	GN002999.1	Q9H6F5	46.2	117	126	360	5.88e-09	55.8	CCD86_HUMAN	Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain)	Homo sapiens (Human)	chromosome segregation [GO:0007059]; mitotic nuclear division [GO:0140014]	RNA binding [GO:0003723]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0007059; GO:0140014
GN003000	GN003000.1	Q80TQ5	27.3	1053	1011	1018	1.04e-86	304	PKHM2_MOUSE	Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2)	Mus musculus (Mouse)	autophagosome-lysosome fusion [GO:0061909]; Golgi organization [GO:0007030]; late endosome to lysosome transport [GO:1902774]; lysosome localization [GO:0032418]; natural killer cell mediated cytotoxicity [GO:0042267]; regulation of protein localization [GO:0032880]	kinesin binding [GO:0019894]	autolysosome [GO:0044754]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]	GO:0005737; GO:0005764; GO:0005765; GO:0007030; GO:0010008; GO:0019894; GO:0032418; GO:0032880; GO:0042267; GO:0044754; GO:0061909; GO:1902774
GN003004	GN003004.1	P79761	40.0	428	425	528	4.07e-114	347	CP1A5_CHICK	Cytochrome P450 1A5 (EC 1.14.14.1) (CYPIA5) (Cytochrome P450 TCDDAA)	Gallus gallus (Chicken)	cellular detoxification [GO:1990748]; cellular response to mycotoxin [GO:0036146]; estrogen metabolic process [GO:0008210]; response to antibiotic [GO:0046677]; steroid catabolic process [GO:0006706]; toxin metabolic process [GO:0009404]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; steroid hydroxylase activity [GO:0008395]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]	GO:0005506; GO:0005739; GO:0005789; GO:0006706; GO:0006805; GO:0008210; GO:0008392; GO:0008395; GO:0009404; GO:0016712; GO:0019825; GO:0020037; GO:0036146; GO:0042178; GO:0043231; GO:0046677; GO:1990748
GN003005	GN003005.1	Q9HCX4	35.9	501	556	862	2.59e-72	250	TRPC7_HUMAN	Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7)	Homo sapiens (Human)	calcium ion transmembrane transport [GO:0070588]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338]	calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]	cation channel complex [GO:0034703]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0005262; GO:0005635; GO:0005886; GO:0007338; GO:0015279; GO:0034703; GO:0048471; GO:0051480; GO:0070588; GO:0070679
GN003007	GN003007.1	Q96ST8	32.9	504	790	783	2.12e-59	219	CEP89_HUMAN	Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123)	Homo sapiens (Human)	chemical synaptic transmission [GO:0007268]; cilium assembly [GO:0060271]; mitochondrial respiratory chain complex IV assembly [GO:0033617]; mitochondrion organization [GO:0007005]; non-motile cilium assembly [GO:1905515]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; spindle pole [GO:0000922]; synapse [GO:0045202]	GO:0000922; GO:0005758; GO:0005813; GO:0005814; GO:0005829; GO:0007005; GO:0007268; GO:0031514; GO:0033617; GO:0036064; GO:0045202; GO:0060271; GO:0097539; GO:0097730; GO:1905515
GN003009	GN003009.1	Q9V5N8	28.0	264	343	3579	3.91e-13	74.3	STAN_DROME	Protocadherin-like wing polarity protein stan (Protein flamingo) (Protein starry night)	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion [GO:0016339]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion mediated by cadherin [GO:0044331]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; homophilic cell-cell adhesion [GO:0007156]; morphogenesis of a polarized epithelium [GO:0001738]; mushroom body development [GO:0016319]; ommatidial rotation [GO:0016318]; positive regulation of axon extension [GO:0045773]; positive regulation of axon guidance [GO:1902669]; R3/R4 development [GO:0048057]; regulation of axonogenesis [GO:0050770]; regulation of synapse assembly [GO:0051963]; regulation of tube length, open tracheal system [GO:0035159]; segment polarity determination [GO:0007367]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001736; GO:0001737; GO:0001738; GO:0004888; GO:0004930; GO:0005509; GO:0005886; GO:0005911; GO:0005912; GO:0007156; GO:0007166; GO:0007367; GO:0007409; GO:0007411; GO:0016020; GO:0016318; GO:0016319; GO:0016324; GO:0016339; GO:0016358; GO:0035159; GO:0042067; GO:0044331; GO:0045773; GO:0048057; GO:0048813; GO:0050770; GO:0050839; GO:0051963; GO:0070593; GO:1902669
GN003010	GN003010.1	Q6P4W8	64.0	430	430	432	3.85e-190	537	PCH2_XENTR	Pachytene checkpoint protein 2 homolog (Thyroid hormone receptor interactor 13 homolog) (Thyroid receptor-interacting protein 13 homolog) (TR-interacting protein 13 homolog) (TRIP-13 homolog)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	double-strand break repair [GO:0006302]; meiotic recombination checkpoint signaling [GO:0051598]; oogenesis [GO:0048477]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]		GO:0005524; GO:0006302; GO:0007130; GO:0007131; GO:0007283; GO:0016887; GO:0042802; GO:0048477; GO:0051598
GN003011	GN003011.1	E7F4Z4	44.9	265	636	578	1.65e-36	147	ZDHC1_DANRE	Palmitoyltransferase ZDHHC1 (EC 2.3.1.225) (DHHC domain-containing protein 1) (Zinc finger DHHC domain-containing protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	antiviral innate immune response [GO:0140374]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein targeting to membrane [GO:0006612]	protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]	GO:0005783; GO:0005789; GO:0005794; GO:0006612; GO:0010008; GO:0019706; GO:0140374; GO:1900227
GN003013	GN003013.1	P09487	50.0	236	273	524	1.87e-71	231	PPBT_BOVIN	Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1)	Bos taurus (Bovine)	biomineral tissue development [GO:0031214]; bone mineralization [GO:0030282]; positive regulation of cold-induced thermogenesis [GO:0120162]	5'-nucleotidase activity [GO:0008253]; ADP phosphatase activity [GO:0043262]; alkaline phosphatase activity [GO:0004035]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; inorganic diphosphate phosphatase activity [GO:0004427]; phosphoamidase activity [GO:0050187]; phosphoethanolamine phosphatase activity [GO:0052732]; pyridoxal phosphatase activity [GO:0033883]; pyrophosphatase activity [GO:0016462]	extracellular membrane-bounded organelle [GO:0065010]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	GO:0004035; GO:0004427; GO:0005509; GO:0005758; GO:0005886; GO:0008253; GO:0016462; GO:0016887; GO:0030282; GO:0031214; GO:0031966; GO:0033883; GO:0043262; GO:0050187; GO:0052732; GO:0065010; GO:0120162
GN003014	GN003014.1	Q62280	67.9	78	523	418	3.83e-20	96.3	SSXT_MOUSE	Protein SSXT (Protein SYT) (Synovial sarcoma-associated Ss18-alpha)	Mus musculus (Mouse)	cell morphogenesis [GO:0000902]; chromatin remodeling [GO:0006338]; cytoskeleton organization [GO:0007010]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of cell differentiation [GO:0045596]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]	transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; microtubule cytoskeleton [GO:0015630]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]	GO:0000226; GO:0000785; GO:0000902; GO:0003713; GO:0005634; GO:0005654; GO:0006338; GO:0006357; GO:0007010; GO:0008284; GO:0009410; GO:0015630; GO:0016514; GO:0035556; GO:0045596; GO:0045944; GO:0048013; GO:0071564; GO:0097150; GO:0140288; GO:1902459
GN003025	GN003025.1	Q9Z0K8	48.9	411	438	512	1.37e-117	356	VNN1_MOUSE	Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Vascular non-inflammatory molecule 1) (Vanin-1)	Mus musculus (Mouse)	acute inflammatory response [GO:0002526]; cell-cell adhesion [GO:0098609]; chronic inflammatory response [GO:0002544]; coenzyme A catabolic process [GO:0015938]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; pantothenate metabolic process [GO:0015939]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of T cell differentiation in thymus [GO:0033089]	GPI anchor binding [GO:0034235]; pantetheine hydrolase activity [GO:0017159]	extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0002526; GO:0002544; GO:0005576; GO:0005886; GO:0006954; GO:0015938; GO:0015939; GO:0016020; GO:0017159; GO:0033089; GO:0034235; GO:0045087; GO:0098609; GO:1902177
GN003026	GN003026.1	Q80XI3	43.3	663	675	1579	9.39e-142	454	IF4G3_MOUSE	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII)	Mus musculus (Mouse)	positive regulation of meiosis I [GO:0060903]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; translational initiation [GO:0006413]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; eukaryotic translation initiation factor 4F complex [GO:0016281]; synapse [GO:0045202]	GO:0001934; GO:0003723; GO:0003743; GO:0005737; GO:0006413; GO:0007283; GO:0007286; GO:0016281; GO:0045202; GO:0045727; GO:0060903
GN003027	GN003027.1	Q9NSD9	57.7	591	542	589	2.21e-230	650	SYFB_HUMAN	Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS)	Homo sapiens (Human)	phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290]; translation [GO:0006412]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; phenylalanine-tRNA ligase complex [GO:0009328]	GO:0000287; GO:0003723; GO:0004826; GO:0005524; GO:0005654; GO:0005737; GO:0005829; GO:0006412; GO:0006432; GO:0009328; GO:0016020; GO:0051290
GN003028	GN003028.1	Q3UY96	39.9	1570	1692	1578	7.89e-316	946	CFA74_MOUSE	Cilia- and flagella-associated protein 74	Mus musculus (Mouse)	axoneme assembly [GO:0035082]		axoneme [GO:0005930]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005634; GO:0005737; GO:0005930; GO:0035082; GO:0036126
GN003030	GN003030.1	Q8N465	63.5	337	357	521	6.43e-149	433	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39)	Homo sapiens (Human)	2-oxoglutarate metabolic process [GO:0006103]; lactate metabolic process [GO:0006089]; malate metabolic process [GO:0006108]; protein destabilization [GO:0031648]; response to cobalt ion [GO:0032025]; response to manganese ion [GO:0010042]; response to zinc ion [GO:0010043]; tartrate metabolic process [GO:1901275]	(R)-2-hydroxyglutarate dehydrogenase activity [GO:0051990]; FAD binding [GO:0071949]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0006089; GO:0006103; GO:0006108; GO:0008270; GO:0010042; GO:0010043; GO:0031648; GO:0032025; GO:0051990; GO:0071949; GO:1901275
GN003031	GN003031.1	Q9M9E8	27.1	266	378	943	2.79e-21	99.4	JMJ21_ARATH	Lysine-specific demethylase JMJ21 (EC 1.14.11.-) (F-box protein JMJ21) (Jumonji domain-containing protein 21) (AtJMJ21) (Protein JUMONJI 21) (Lysine-specific histone demethylase JMJ21) ([histone H3]-trimethyl-L-lysine monodemethylase JMJ21)	Arabidopsis thaliana (Mouse-ear cress)			nucleus [GO:0005634]	GO:0005634
GN003033	GN003033.1	O00411	36.8	1036	1288	1230	6.36e-200	620	RPOM_HUMAN	DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)	Homo sapiens (Human)	mitochondrial DNA replication [GO:0006264]; mitochondrial transcription [GO:0006390]; transcription initiation at mitochondrial promoter [GO:0006391]	3'-5'-RNA exonuclease activity [GO:0000175]; DNA-directed RNA polymerase activity [GO:0003899]; mitochondrial promoter sequence-specific DNA binding [GO:0001018]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]	mitochondrial DNA-directed RNA polymerase complex [GO:0034245]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	GO:0000175; GO:0001018; GO:0003723; GO:0003899; GO:0005739; GO:0005759; GO:0006264; GO:0006390; GO:0006391; GO:0032991; GO:0034245; GO:0042645; GO:0043565
GN003034	GN003034.1	Q6NRV0	29.8	252	459	464	2.21e-22	102	TRAIP_XENLA	E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (TRAF-interacting protein)	Xenopus laevis (African clawed frog)	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; interstrand cross-link repair [GO:0036297]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; replication fork processing [GO:0031297]	MCM complex binding [GO:1904931]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0004842; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006281; GO:0006974; GO:0016567; GO:0031297; GO:0036297; GO:0061630; GO:0090734; GO:0106300; GO:1904931
GN003036	GN003036.1	Q2L969	46.9	226	239	267	1.99e-71	222	MTX2_PIG	Metaxin-2 (Mitochondrial outer membrane import complex protein 2)	Sus scrofa (Pig)	mitochondrial transport [GO:0006839]		SAM complex [GO:0001401]	GO:0001401; GO:0006839
GN003037	GN003037.1	Q96CD2	62.1	177	188	204	3.34e-79	237	COAC_HUMAN	Phosphopantothenoylcysteine decarboxylase (PPC-DC) (EC 4.1.1.36) (CoaC)	Homo sapiens (Human)	coenzyme A biosynthetic process [GO:0015937]	FMN binding [GO:0010181]; identical protein binding [GO:0042802]; phosphopantothenoylcysteine decarboxylase activity [GO:0004633]	cytosol [GO:0005829]; phosphopantothenoylcysteine decarboxylase complex [GO:0071513]	GO:0004633; GO:0005829; GO:0010181; GO:0015937; GO:0042802; GO:0071513
GN003038	GN003038.1	Q9DAM1	51.3	351	381	415	2.49e-32	129	LRC34_MOUSE	Leucine-rich repeat-containing protein 34	Mus musculus (Mouse)	gene expression [GO:0010467]; telomere maintenance [GO:0000723]		cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0000723; GO:0005634; GO:0005730; GO:0005737; GO:0010467
GN003039	GN003039.1	D3YZI9	33.1	121	212	523	2.55e-09	59.7	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN003043	GN003043.1	Q9H4Z3	59.6	483	621	704	4.04e-212	611	CAPAM_HUMAN	mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121)	Homo sapiens (Human)	mRNA processing [GO:0006397]; negative regulation of translation [GO:0017148]; positive regulation of translation [GO:0045727]	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity [GO:0016422]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; S-adenosyl-L-methionine binding [GO:1904047]	intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0006397; GO:0015630; GO:0016422; GO:0017148; GO:0045171; GO:0045727; GO:0099122; GO:1904047; GO:1990269
GN003044	GN003044.1	Q58DN7	45.7	116	122	586	1.37e-28	111	ACSF3_BOVIN	Malonate--CoA ligase ACSF3, mitochondrial (EC 6.2.1.76) (Acyl-CoA synthetase family member 3)	Bos taurus (Bovine)	fatty acid biosynthetic process [GO:0006633]; malonate catabolic process [GO:0090410]	malonyl-CoA synthetase activity [GO:0090409]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	mitochondrion [GO:0005739]	GO:0005739; GO:0006633; GO:0031957; GO:0090409; GO:0090410
GN003045	GN003045.1	Q58DN7	42.0	436	471	586	6.01e-105	327	ACSF3_BOVIN	Malonate--CoA ligase ACSF3, mitochondrial (EC 6.2.1.76) (Acyl-CoA synthetase family member 3)	Bos taurus (Bovine)	fatty acid biosynthetic process [GO:0006633]; malonate catabolic process [GO:0090410]	malonyl-CoA synthetase activity [GO:0090409]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	mitochondrion [GO:0005739]	GO:0005739; GO:0006633; GO:0031957; GO:0090409; GO:0090410
GN003049	GN003049.1	Q8BGT5	62.3	480	516	522	1.44e-217	614	ALAT2_MOUSE	Alanine aminotransferase 2 (mALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2)	Mus musculus (Mouse)	2-oxoglutarate metabolic process [GO:0006103]; gluconeogenesis [GO:0006094]; L-alanine biosynthetic process [GO:0042852]; L-alanine catabolic process [GO:0042853]	L-alanine:2-oxoglutarate transaminase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]	extracellular region [GO:0005576]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004021; GO:0005576; GO:0005739; GO:0005759; GO:0006094; GO:0006103; GO:0030170; GO:0042852; GO:0042853
GN003050	GN003050.1	Q9I8C7	33.6	301	441	452	3.21e-61	208	ACH10_CHICK	Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0050910; GO:0097060; GO:1902495
GN003051	GN003051.1	Q28IA3	44.2	278	340	292	5.50e-80	248	AKTIP_XENTR	AKT-interacting protein (Fused toes protein homolog)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]		FHF complex [GO:0070695]; plasma membrane [GO:0005886]	GO:0005886; GO:0007032; GO:0007040; GO:0008333; GO:0045022; GO:0070695
GN003052	GN003052.1	Q9I8C7	32.5	317	475	452	3.53e-63	214	ACH10_CHICK	Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0050910; GO:0097060; GO:1902495
GN003053	GN003053.1	Q9I8C7	32.7	346	475	452	4.38e-65	219	ACH10_CHICK	Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0050910; GO:0097060; GO:1902495
GN003059	GN003059.1	P32320	48.8	129	142	146	9.40e-40	133	CDD_HUMAN	Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase)	Homo sapiens (Human)	cellular response to external biotic stimulus [GO:0071217]; CMP catabolic process [GO:0006248]; cytosine metabolic process [GO:0019858]; dCMP catabolic process [GO:0006249]; deoxycytidine catabolic process [GO:0006217]; pyrimidine-containing compound salvage [GO:0008655]; UMP salvage [GO:0044206]; uridine biosynthetic process [GO:0046109]	cytidine deaminase activity [GO:0004126]; identical protein binding [GO:0042802]; nucleoside binding [GO:0001882]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; tertiary granule lumen [GO:1904724]	GO:0001882; GO:0004126; GO:0005576; GO:0005829; GO:0006217; GO:0006248; GO:0006249; GO:0008270; GO:0008655; GO:0019858; GO:0034774; GO:0042802; GO:0042803; GO:0044206; GO:0046109; GO:0071217; GO:1904724; GO:1904813
GN003061	GN003061.1	P78364	42.0	288	869	1004	2.90e-41	167	PHC1_HUMAN	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]	GO:0000785; GO:0001739; GO:0003682; GO:0005634; GO:0005654; GO:0006338; GO:0008270; GO:0016604; GO:0031507; GO:0031519; GO:0035102; GO:0042393; GO:0045892
GN003063	GN003063.1	Q29HY3	88.5	191	184	191	8.45e-122	344	CDC42_DROPS	Cdc42 homolog (EC 3.6.5.2)	Drosophila pseudoobscura pseudoobscura (Fruit fly)	ameboidal-type cell migration [GO:0001667]; anatomical structure morphogenesis [GO:0009653]; cellular process involved in reproduction in multicellular organism [GO:0022412]; developmental process involved in reproduction [GO:0003006]; epithelium development [GO:0060429]; hemocyte migration [GO:0035099]; maintenance of protein location [GO:0045185]; melanization defense response [GO:0035006]; positive regulation of cellular component organization [GO:0051130]; positive regulation of protein kinase activity [GO:0045860]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0001667; GO:0003006; GO:0003924; GO:0003925; GO:0005525; GO:0005737; GO:0005886; GO:0005912; GO:0007264; GO:0009653; GO:0022412; GO:0035006; GO:0035099; GO:0045185; GO:0045860; GO:0051130; GO:0060429
GN003064	GN003064.1	Q19187	24.9	543	992	1679	9.68e-48	189	GCY12_CAEEL	Receptor-type guanylate cyclase gcy-12 (EC 4.6.1.2)	Caenorhabditis elegans	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; negative regulation of dauer larval development [GO:0061067]; negative regulation of multicellular organism growth [GO:0040015]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of locomotion involved in locomotory behavior [GO:0090325]; regulation of multicellular organism growth [GO:0040014]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	cilium [GO:0005929]; dendrite [GO:0030425]; non-motile cilium [GO:0097730]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0005929; GO:0006182; GO:0007168; GO:0030425; GO:0035556; GO:0040014; GO:0040015; GO:0043204; GO:0061067; GO:0090325; GO:0097730
GN003070	GN003070.1	Q23682	28.1	513	965	1122	2.33e-51	200	GCY5_CAEEL	Receptor-type guanylate cyclase gcy-5 (EC 4.6.1.2)	Caenorhabditis elegans	cGMP biosynthetic process [GO:0006182]; chemosensory behavior [GO:0007635]; chemotaxis [GO:0006935]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]; response to salt [GO:1902074]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	cilium [GO:0005929]; plasma membrane [GO:0005886]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0005929; GO:0006182; GO:0006935; GO:0007168; GO:0007635; GO:0035556; GO:1902074
GN003071	GN003071.1	Q99KP6	65.2	511	509	504	1.14e-210	595	PRP19_MOUSE	Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)	Mus musculus (Mouse)	DNA damage checkpoint signaling [GO:0000077]; double-strand break repair via nonhomologous end joining [GO:0006303]; inner cell mass cell proliferation [GO:0001833]; intracellular protein localization [GO:0008104]; lipid biosynthetic process [GO:0008610]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of neuron differentiation [GO:0045666]; proteasomal protein catabolic process [GO:0010498]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of neuron differentiation [GO:0045664]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; DNA replication factor A complex [GO:0005662]; lipid droplet [GO:0005811]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; site of double-strand break [GO:0035861]; spindle [GO:0005819]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000077; GO:0000209; GO:0000244; GO:0000245; GO:0000398; GO:0000974; GO:0001833; GO:0005634; GO:0005662; GO:0005681; GO:0005737; GO:0005811; GO:0005819; GO:0006303; GO:0008104; GO:0008610; GO:0010498; GO:0016607; GO:0034450; GO:0035861; GO:0042802; GO:0045664; GO:0045665; GO:0045666; GO:0048026; GO:0048711; GO:0061630; GO:0070534; GO:0071006; GO:0071007; GO:0071013; GO:0071014; GO:0071020
GN003072	GN003072.1	Q8N9F7	56.1	57	90	314	3.09e-13	66.2	GDPD1_HUMAN	Lysophospholipase D GDPD1 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 4) (Glycerophosphodiester phosphodiesterase domain-containing protein 1)	Homo sapiens (Human)	glycerophospholipid catabolic process [GO:0046475]; N-acylethanolamine metabolic process [GO:0070291]	phosphatidylcholine lysophospholipase A1 activity [GO:0004622]; phosphoric diester hydrolase activity [GO:0008081]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	GO:0004622; GO:0005737; GO:0005783; GO:0005789; GO:0008081; GO:0016020; GO:0046475; GO:0048471; GO:0070291
GN003074	GN003074.1	Q9BXJ4	30.5	128	127	246	8.30e-10	57.8	C1QT3_HUMAN	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	Homo sapiens (Human)	fat cell differentiation [GO:0045444]; intracellular triglyceride homeostasis [GO:0035356]; maintenance of synapse structure [GO:0099558]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001819; GO:0010629; GO:0016020; GO:0032715; GO:0032991; GO:0035356; GO:0042802; GO:0043083; GO:0045202; GO:0045444; GO:0045721; GO:0050728; GO:0070062; GO:0070165; GO:0071638; GO:0099550; GO:0099558; GO:1901223
GN003077	GN003077.1	Q9CUX1	43.5	69	101	758	2.71e-11	61.6	P52K_MOUSE	52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (THAP domain-containing protein 0) (THAP domain-containing protein 12)	Mus musculus (Mouse)		protein dimerization activity [GO:0046983]	nucleus [GO:0005634]	GO:0005634; GO:0046983
GN003080	GN003080.1	Q9CR14	42.5	374	373	375	1.78e-115	343	FANCL_MOUSE	E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia group L protein homolog) (Proliferation of germ cells protein) (RING-type E3 ubiquitin transferase FANCL)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; gamete generation [GO:0007276]; interstrand cross-link repair [GO:0036297]; protein monoubiquitination [GO:0006513]; regulation of cell population proliferation [GO:0042127]; single fertilization [GO:0007338]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; Fanconi anaemia nuclear complex [GO:0043240]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]	GO:0000785; GO:0004842; GO:0005634; GO:0005635; GO:0005737; GO:0006281; GO:0006513; GO:0006974; GO:0007276; GO:0007338; GO:0016604; GO:0031625; GO:0036297; GO:0042127; GO:0043240; GO:0061630
GN003084	GN003084.1	Q6NRW2	26.4	390	517	610	7.06e-21	99.8	SPDLB_XENLA	Protein Spindly-B (Coiled-coil domain-containing protein 99-B) (Spindle apparatus coiled-coil domain-containing protein 1-B)	Xenopus laevis (African clawed frog)	establishment of mitotic spindle orientation [GO:0000132]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]	kinetochore binding [GO:0043515]	nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922]	GO:0000132; GO:0000922; GO:0000940; GO:0005634; GO:0007080; GO:0007094; GO:0034501; GO:0043515
GN003086	GN003086.1	A1ZA47	46.2	91	137	2194	7.94e-21	90.5	ZASP_DROME	PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein)	Drosophila melanogaster (Fruit fly)	actin cytoskeleton organization [GO:0030036]; muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; regulation of cell-matrix adhesion [GO:0001952]	actin binding [GO:0003779]; actinin binding [GO:0042805]; muscle alpha-actinin binding [GO:0051371]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; basolateral plasma membrane [GO:0016323]; cell leading edge [GO:0031252]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; muscle tendon junction [GO:0005927]; stress fiber [GO:0001725]; Z disc [GO:0030018]; zonula adherens [GO:0005915]	GO:0001725; GO:0001952; GO:0003779; GO:0005912; GO:0005915; GO:0005925; GO:0005927; GO:0015629; GO:0016323; GO:0030018; GO:0030036; GO:0030239; GO:0031252; GO:0031941; GO:0042805; GO:0045177; GO:0045178; GO:0051371; GO:0061061
GN003090	GN003090.1	Q23682	28.1	513	965	1122	2.33e-51	200	GCY5_CAEEL	Receptor-type guanylate cyclase gcy-5 (EC 4.6.1.2)	Caenorhabditis elegans	cGMP biosynthetic process [GO:0006182]; chemosensory behavior [GO:0007635]; chemotaxis [GO:0006935]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]; response to salt [GO:1902074]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	cilium [GO:0005929]; plasma membrane [GO:0005886]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0005929; GO:0006182; GO:0006935; GO:0007168; GO:0007635; GO:0035556; GO:1902074
GN003091	GN003091.1	P18887	39.5	296	393	633	3.53e-52	187	XRCC1_HUMAN	DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)	Homo sapiens (Human)	base-excision repair [GO:0006284]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of protein ADP-ribosylation [GO:0010836]; regulation of base-excision repair [GO:1905051]; regulation of DNA repair [GO:0006282]; response to hydroperoxide [GO:0033194]; single strand break repair [GO:0000012]; telomeric DNA-containing double minutes formation [GO:0061819]	3' overhang single-stranded DNA endonuclease activity [GO:1990599]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; enzyme binding [GO:0019899]; oxidized DNA binding [GO:0032356]; poly-ADP-D-ribose binding [GO:0072572]; single-strand break-containing DNA binding [GO:1990165]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; DNA ligase III-XRCC1 complex [GO:0070421]; ERCC4-ERCC1 complex [GO:0070522]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0000012; GO:0000781; GO:0000785; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0006282; GO:0006284; GO:0006302; GO:0006303; GO:0010836; GO:0019899; GO:0032356; GO:0033194; GO:0061819; GO:0070421; GO:0070522; GO:0072572; GO:0090734; GO:0160002; GO:1905051; GO:1905765; GO:1990165; GO:1990599
GN003093	GN003093.1	Q5RFD6	49.4	360	366	443	4.65e-125	370	CBPM_PONAB	Carboxypeptidase M (CPM) (EC 3.4.17.12)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	peptide metabolic process [GO:0006518]; protein processing [GO:0016485]	metallocarboxypeptidase activity [GO:0004181]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]	GO:0004181; GO:0005886; GO:0006518; GO:0008270; GO:0016485
GN003097	GN003097.1	O93603	46.3	175	227	395	2.37e-43	153	TRHR_CHICK	Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor)	Gallus gallus (Chicken)	phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	thyrotropin-releasing hormone receptor activity [GO:0004997]	plasma membrane [GO:0005886]	GO:0004997; GO:0005886; GO:0007200
GN003100	GN003100.1	P51909	41.0	183	183	189	1.25e-39	136	APOD_CAVPO	Apolipoprotein D (Apo-D) (ApoD)	Cavia porcellus (Guinea pig)	brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246]	cholesterol binding [GO:0015485]	cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]	GO:0000302; GO:0005576; GO:0006006; GO:0006629; GO:0006869; GO:0007420; GO:0010642; GO:0014012; GO:0015485; GO:0022626; GO:0030425; GO:0042246; GO:0042308; GO:0043025; GO:0048471; GO:0048662; GO:0048678; GO:0051895; GO:0060588; GO:0071638; GO:1900016; GO:2000098; GO:2000405
GN003101	GN003101.1	Q80V03	47.7	541	608	582	1.39e-159	472	ADCK5_MOUSE	Uncharacterized aarF domain-containing protein kinase 5 (EC 2.7.11.-)	Mus musculus (Mouse)			membrane [GO:0016020]; mitochondrion [GO:0005739]	GO:0005739; GO:0016020
GN003105	GN003105.1	P97772	32.0	503	2775	1199	2.01e-56	220	GRM1_MOUSE	Metabotropic glutamate receptor 1 (mGluR1)	Mus musculus (Mouse)	calcium-mediated signaling [GO:0019722]; cellular response to electrical stimulus [GO:0071257]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; G protein-coupled receptor signaling pathway [GO:0007186]; L-glutamate import across plasma membrane [GO:0098712]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of MAPK cascade [GO:0043410]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]; synaptic signaling via neuropeptide [GO:0099538]	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled neurotransmitter receptor activity [GO:0099528]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; nuclear estrogen receptor binding [GO:0030331]; PLC activating G protein-coupled glutamate receptor activity [GO:0001639]	axon [GO:0030424]; dendriole [GO:0044293]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; G protein-coupled receptor dimeric complex [GO:0038037]; G protein-coupled receptor homodimeric complex [GO:0038038]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0001639; GO:0001640; GO:0005634; GO:0005886; GO:0007186; GO:0007200; GO:0007206; GO:0007216; GO:0007268; GO:0007626; GO:0008066; GO:0014069; GO:0019233; GO:0019722; GO:0030331; GO:0030424; GO:0030425; GO:0038037; GO:0038038; GO:0042734; GO:0043005; GO:0043025; GO:0043197; GO:0043410; GO:0044293; GO:0044309; GO:0045211; GO:0051930; GO:0051966; GO:0071257; GO:0098685; GO:0098712; GO:0098839; GO:0098978; GO:0099528; GO:0099530; GO:0099538
GN003106	GN003106.1	A8XNX8	27.5	298	383	636	5.12e-33	133	LGC4_CAEBR	Ligand-gated ion channel 4	Caenorhabditis briggsae	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:1902495
GN003107	GN003107.1	Q9M2U3	30.8	253	263	406	2.39e-27	112	ALPL_ARATH	Protein ALP1-like (EC 3.1.-.-)	Arabidopsis thaliana (Mouse-ear cress)			histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634
GN003108	GN003108.1	P46012	35.9	142	472	952	3.46e-10	66.2	YKI5_CAEEL	Germ layers disorganized gldi-3	Caenorhabditis elegans	regulation of gene expression [GO:0010468]		nucleus [GO:0005634]	GO:0005634; GO:0010468
GN003109	GN003109.1	Q567I9	71.5	214	215	214	7.44e-111	319	CB5D1_DANRE	Cytochrome b5 domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium movement [GO:0003341]; regulation of cilium beat frequency [GO:0003356]		axoneme [GO:0005930]	GO:0003341; GO:0003356; GO:0005930
GN003110	GN003110.1	A2BIG9	60.8	79	102	109	8.96e-32	110	NAA38_DANRE	N-alpha-acetyltransferase 38, NatC auxiliary subunit (LSM domain-containing protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	negative regulation of apoptotic process [GO:0043066]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; NatC complex [GO:0031417]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005737; GO:0031417; GO:0043066
GN003113	GN003113.1	Q91845	44.7	1013	1010	986	2.32e-266	775	EPA4A_XENLA	Ephrin type-A receptor 4-A (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK-1) (xSEK-1)	Xenopus laevis (African clawed frog)	axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; regulation of GTPase activity [GO:0043087]	ATP binding [GO:0005524]; GPI-linked ephrin receptor activity [GO:0005004]; transmembrane-ephrin receptor activity [GO:0005005]	dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]	GO:0005004; GO:0005005; GO:0005524; GO:0005769; GO:0005886; GO:0007411; GO:0030425; GO:0031901; GO:0043087; GO:0048013
GN003116	GN003116.1	A4WFX9	31.9	191	826	260	7.03e-12	70.1	TATD_ENT38	3'-5' ssDNA/RNA exonuclease TatD (EC 3.1.11.-) (EC 3.1.13.-) (DNase TatD)	Enterobacter sp. (strain 638)		3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]	cytosol [GO:0005829]	GO:0000175; GO:0000287; GO:0005829; GO:0008310
GN003118	GN003118.1	Q8TDB6	49.4	176	196	740	2.30e-52	181	DTX3L_HUMAN	E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)	Homo sapiens (Human)	DNA damage checkpoint signaling [GO:0000077]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; endosome to lysosome transport [GO:0008333]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; Notch signaling pathway [GO:0007219]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor catabolic process [GO:2000646]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone H4K91 ubiquitin ligase activity [GO:0141000]; histone ubiquitin ligase activity [GO:0140852]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]; STAT family protein binding [GO:0097677]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000077; GO:0002230; GO:0004842; GO:0004857; GO:0005634; GO:0005654; GO:0005737; GO:0005764; GO:0005765; GO:0005829; GO:0006302; GO:0006511; GO:0007219; GO:0008333; GO:0016567; GO:0019899; GO:0031901; GO:0032092; GO:0032991; GO:0035563; GO:0042393; GO:0044389; GO:0045893; GO:0051444; GO:0051865; GO:0061630; GO:0070936; GO:0097677; GO:0140768; GO:0140852; GO:0140861; GO:0141000; GO:1900182; GO:1902966; GO:2000646
GN003119	GN003119.1	P46012	35.9	142	534	952	4.51e-10	66.2	YKI5_CAEEL	Germ layers disorganized gldi-3	Caenorhabditis elegans	regulation of gene expression [GO:0010468]		nucleus [GO:0005634]	GO:0005634; GO:0010468
GN003121	GN003121.1	Q567I9	71.5	214	215	214	7.44e-111	319	CB5D1_DANRE	Cytochrome b5 domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium movement [GO:0003341]; regulation of cilium beat frequency [GO:0003356]		axoneme [GO:0005930]	GO:0003341; GO:0003356; GO:0005930
GN003128	GN003128.1	Q52556	32.3	524	582	528	1.44e-82	271	LPAKS_PSES9	Linear primary-alkylsulfatase (EC 3.1.6.21) (SDSase) (Type III linear primary-alkylsulfatase)	Pseudomonas sp. (strain ATCC 19151)	dodecyl sulfate metabolic process [GO:0018909]	linear primary-alkylsulfatase activity [GO:0018741]; protein dimerization activity [GO:0046983]		GO:0018741; GO:0018909; GO:0046983
GN003131	GN003131.1	P55041	30.6	206	325	295	1.52e-21	95.9	GEM_MOUSE	GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR)	Mus musculus (Mouse)	chromosome organization [GO:0051276]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]	calcium channel regulator activity [GO:0005246]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	cytoplasmic side of plasma membrane [GO:0009898]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle midzone [GO:0051233]	GO:0000278; GO:0000287; GO:0003924; GO:0005246; GO:0005525; GO:0005634; GO:0005886; GO:0009898; GO:0019003; GO:0030496; GO:0051233; GO:0051276; GO:0051310; GO:0072686
GN003132	GN003132.1	P55041	31.0	145	234	295	1.31e-09	60.5	GEM_MOUSE	GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR)	Mus musculus (Mouse)	chromosome organization [GO:0051276]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]	calcium channel regulator activity [GO:0005246]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	cytoplasmic side of plasma membrane [GO:0009898]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle midzone [GO:0051233]	GO:0000278; GO:0000287; GO:0003924; GO:0005246; GO:0005525; GO:0005634; GO:0005886; GO:0009898; GO:0019003; GO:0030496; GO:0051233; GO:0051276; GO:0051310; GO:0072686
GN003134	GN003134.1	O35929	35.8	179	286	297	6.32e-18	85.1	REM1_MOUSE	GTP-binding protein REM 1 (Rad and Gem-like GTP-binding protein 1)	Mus musculus (Mouse)	negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; regulation of skeletal muscle contraction by calcium ion signaling [GO:0014722]	calcium channel regulator activity [GO:0005246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; transmembrane transporter binding [GO:0044325]	I band [GO:0031674]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]	GO:0003924; GO:0005246; GO:0005525; GO:0005886; GO:0014722; GO:0030315; GO:0031674; GO:0044325; GO:1904878
GN003137	GN003137.1	D3YXG0	52.2	90	197	5634	1.94e-27	112	HMCN1_MOUSE	Hemicentin-1 (Fibulin-6) (FIBL-6)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]; response to bacterium [GO:0009617]	calcium ion binding [GO:0005509]; cell adhesion mediator activity [GO:0098631]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; muscle tendon junction [GO:0005927]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005509; GO:0005576; GO:0005604; GO:0005737; GO:0005886; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0009617; GO:0030036; GO:0030054; GO:0031012; GO:0032154; GO:0070161; GO:0071711; GO:0098631; GO:0140144
GN003138	GN003138.1	Q6P3Z3	50.0	62	223	569	1.94e-11	66.2	THAP4_MOUSE	Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric nitrobindin) (Nb(III)) (THAP domain-containing protein 4)	Mus musculus (Mouse)	cellular response to reactive nitrogen species [GO:1902170]; nitrate metabolic process [GO:0042126]	heme binding [GO:0020037]; identical protein binding [GO:0042802]; nitric oxide binding [GO:0070026]; peroxynitrite isomerase activity [GO:0062213]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0020037; GO:0042126; GO:0042802; GO:0062213; GO:0070026; GO:1902170
GN003140	GN003140.1	Q96PX9	42.1	95	117	1627	2.87e-14	70.9	PKH4B_HUMAN	Pleckstrin homology domain-containing family G member 4B (PH domain-containing family G member 4B)	Homo sapiens (Human)	axon guidance [GO:0007411]; cell-cell adhesion [GO:0098609]; regulation of small GTPase mediated signal transduction [GO:0051056]	guanyl-nucleotide exchange factor activity [GO:0005085]	anchoring junction [GO:0070161]; basal plasma membrane [GO:0009925]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005085; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0007411; GO:0009925; GO:0019898; GO:0051056; GO:0070161; GO:0098609
GN003142	GN003142.1	Q06A37	45.9	2155	3360	3011	0.0	1613	CHD7_CHICK	ATP-dependent chromatin remodeler CHD7 (EC 3.6.4.-) (Chromo domain-containing protein 7) (CHD-7)	Gallus gallus (Chicken)	central nervous system development [GO:0007417]; chordate embryonic development [GO:0043009]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; cranial nerve development [GO:0021545]; face development [GO:0060324]; genitalia development [GO:0048806]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; limb development [GO:0060173]; nose development [GO:0043584]; regulation of gene expression [GO:0010468]; regulation of growth hormone secretion [GO:0060123]; retina development in camera-type eye [GO:0060041]; secondary palate development [GO:0062009]; skeletal system development [GO:0001501]; T cell differentiation [GO:0030217]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0001501; GO:0003007; GO:0003677; GO:0003682; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006338; GO:0007417; GO:0010468; GO:0016887; GO:0021545; GO:0030217; GO:0042393; GO:0042472; GO:0043009; GO:0043584; GO:0048806; GO:0050890; GO:0060041; GO:0060123; GO:0060173; GO:0060324; GO:0062009; GO:0140658; GO:1990841
GN003143	GN003143.1	O75771	44.2	224	226	328	3.80e-60	194	RA51D_HUMAN	DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD)	Homo sapiens (Human)	DNA repair [GO:0006281]; DNA strand invasion [GO:0042148]; double-strand break repair via homologous recombination [GO:0000724]; reciprocal meiotic recombination [GO:0007131]; supramolecular fiber organization [GO:0097435]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]	ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; gamma-tubulin binding [GO:0043015]; single-stranded DNA binding [GO:0003697]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]	GO:0000722; GO:0000723; GO:0000724; GO:0000781; GO:0003677; GO:0003697; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005813; GO:0005815; GO:0006281; GO:0007131; GO:0008094; GO:0033063; GO:0042148; GO:0043015; GO:0097435; GO:0140664
GN003144	GN003144.1	E9PYK3	45.0	874	2178	1969	2.02e-213	698	PARP4_MOUSE	Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) (mVparp)	Mus musculus (Mouse)	inflammatory response [GO:0006954]	enzyme binding [GO:0019899]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]	GO:0003950; GO:0005634; GO:0005654; GO:0005737; GO:0005819; GO:0005829; GO:0005876; GO:0006954; GO:0019899; GO:0072686; GO:0140806; GO:0140807; GO:1990404
GN003145	GN003145.1	Q0IIF2	76.3	118	116	305	2.12e-54	174	EI2BA_BOVIN	Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha)	Bos taurus (Bovine)	cytoplasmic translational initiation [GO:0002183]; translational initiation [GO:0006413]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]	GO:0002183; GO:0005085; GO:0005829; GO:0005851; GO:0006413
GN003149	GN003149.1	Q64270	61.6	305	441	305	1.37e-117	348	EI2BA_RAT	Translation initiation factor eIF2B subunit alpha (eIF2B GDP-GTP exchange factor subunit alpha)	Rattus norvegicus (Rat)	cytoplasmic translational initiation [GO:0002183]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; oligodendrocyte development [GO:0014003]; positive regulation of translational initiation [GO:0045948]; response to amino acid starvation [GO:1990928]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translation [GO:0006412]; translational initiation [GO:0006413]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2 complex [GO:0005850]; eukaryotic translation initiation factor 2B complex [GO:0005851]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0002183; GO:0003743; GO:0005085; GO:0005525; GO:0005737; GO:0005829; GO:0005850; GO:0005851; GO:0005886; GO:0006412; GO:0006413; GO:0009408; GO:0009749; GO:0014003; GO:0016020; GO:0019003; GO:0042802; GO:0043434; GO:0045948; GO:0050852; GO:1905098; GO:1990928
GN003150	GN003150.1	E9PYK3	38.3	1233	2459	1969	1.50e-233	759	PARP4_MOUSE	Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) (mVparp)	Mus musculus (Mouse)	inflammatory response [GO:0006954]	enzyme binding [GO:0019899]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]	GO:0003950; GO:0005634; GO:0005654; GO:0005737; GO:0005819; GO:0005829; GO:0005876; GO:0006954; GO:0019899; GO:0072686; GO:0140806; GO:0140807; GO:1990404
GN003159	GN003159.1	P55043	39.6	187	371	306	7.39e-22	97.8	RAD_RAT	GTP-binding protein RAD (RAD1) (Ras associated with diabetes)	Rattus norvegicus (Rat)	negative regulation of cell growth [GO:0030308]	calcium channel regulator activity [GO:0005246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; T-tubule [GO:0030315]	GO:0003924; GO:0005246; GO:0005525; GO:0005886; GO:0030308; GO:0030315
GN003160	GN003160.1	P55043	39.7	189	366	306	4.14e-24	103	RAD_RAT	GTP-binding protein RAD (RAD1) (Ras associated with diabetes)	Rattus norvegicus (Rat)	negative regulation of cell growth [GO:0030308]	calcium channel regulator activity [GO:0005246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]; T-tubule [GO:0030315]	GO:0003924; GO:0005246; GO:0005525; GO:0005886; GO:0030308; GO:0030315
GN003167	GN003167.1	Q6DK99	35.6	104	180	111	1.46e-10	58.9	CNFNB_XENLA	Cornifelin homolog B	Xenopus laevis (African clawed frog)				
GN003168	GN003168.1	Q5RHR6	40.6	1345	1338	1298	0.0	968	BROMI_DANRE	Protein broad-minded (TBC1 domain family member 32)	Danio rerio (Zebrafish) (Brachydanio rerio)	axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; non-motile cilium assembly [GO:1905515]; retinal pigment epithelium development [GO:0003406]		cilium [GO:0005929]; cytoplasm [GO:0005737]	GO:0003406; GO:0005737; GO:0005929; GO:0035082; GO:0060271; GO:1905515
GN003171	GN003171.1	Q6P5L8	36.5	252	281	415	7.29e-48	167	HSDL2_DANRE	Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-)	Danio rerio (Zebrafish) (Brachydanio rerio)			mitochondrion [GO:0005739]; peroxisome [GO:0005777]	GO:0005739; GO:0005777
GN003174	GN003174.1	Q9EPL4	52.8	125	135	318	7.11e-44	149	METL9_MOUSE	Protein-L-histidine N-pros-methyltransferase (EC 2.1.1.-) (DORA reverse strand protein) (DREV) (Methyltransferase-like protein 9) (mMETTL9)	Mus musculus (Mouse)		protein-L-histidine N-pros-methyltransferase activity [GO:0106370]	endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]	GO:0005739; GO:0005783; GO:0106370
GN003175	GN003175.1	Q9NP91	54.7	148	165	592	1.38e-50	173	S6A20_HUMAN	Sodium- and chloride-dependent transporter XTRP3 (Sodium/imino-acid transporter 1) (Solute carrier family 6 member 20) (Transporter rB21A homolog)	Homo sapiens (Human)	amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; amino-acid betaine transport [GO:0015838]; glycine import across plasma membrane [GO:1903804]; glycine transport [GO:0015816]; L-isoleucine import across plasma membrane [GO:1903806]; L-proline import across plasma membrane [GO:1904271]; neurotransmitter transport [GO:0006836]; proline import across plasma membrane [GO:1905647]; proline transport [GO:0015824]; sodium ion transmembrane transport [GO:0035725]; transport across blood-brain barrier [GO:0150104]	amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; glycine transmembrane transporter activity [GO:0015187]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-proline transmembrane transporter activity [GO:0015193]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; proline:sodium symporter activity [GO:0005298]; solute:sodium symporter activity [GO:0015370]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0005298; GO:0005886; GO:0006836; GO:0006865; GO:0015171; GO:0015175; GO:0015187; GO:0015188; GO:0015193; GO:0015199; GO:0015370; GO:0015816; GO:0015824; GO:0015838; GO:0016324; GO:0035725; GO:0045211; GO:0089718; GO:0150104; GO:1903804; GO:1903806; GO:1904271; GO:1905647
GN003177	GN003177.1	Q9H0I3	53.2	231	247	377	3.78e-63	204	CF263_HUMAN	Cilia- and flagella-associated protein 263	Homo sapiens (Human)	cilium assembly [GO:0060271]		axoneme [GO:0005930]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; protein-containing complex [GO:0032991]	GO:0005930; GO:0032991; GO:0034451; GO:0036064; GO:0060271
GN003178	GN003178.1	P28020	84.7	352	385	392	1.82e-223	618	CSK21_XENLA	Casein kinase II subunit alpha (CK II) (EC 2.7.11.1)	Xenopus laevis (African clawed frog)	double-strand break repair [GO:0006302]; positive regulation of aggrephagy [GO:1905337]; regulation of cell cycle [GO:0051726]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; nucleus [GO:0005634]; protein kinase CK2 complex [GO:0005956]	GO:0004674; GO:0005524; GO:0005634; GO:0005829; GO:0005956; GO:0006302; GO:0051726; GO:0106310; GO:1905337
GN003179	GN003179.1	Q6B857	99.0	192	193	193	1.28e-137	385	CFA20_BOVIN	Cilia- and flagella-associated protein 20	Bos taurus (Bovine)	cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; positive regulation of cell motility [GO:2000147]; positive regulation of feeding behavior [GO:2000253]; protein polyglutamylation [GO:0018095]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]		axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005634; GO:0005654; GO:0005814; GO:0005879; GO:0005929; GO:0018095; GO:0030317; GO:0031514; GO:0036064; GO:0036126; GO:0060271; GO:0060296; GO:0160112; GO:2000147; GO:2000253
GN003181	GN003181.1	P26270	79.0	195	248	338	6.77e-111	325	PSMD7_DROME	26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Proteasome subunit p39B) (Proteasome subunit p40) (Protein Mov34)	Drosophila melanogaster (Fruit fly)	proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]		cytosol [GO:0005829]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]	GO:0000502; GO:0005654; GO:0005829; GO:0005838; GO:0008541; GO:0010498; GO:0030425; GO:0043161
GN003185	GN003185.1	Q15911	28.9	2118	2247	3703	1.98e-159	555	ZFHX3_HUMAN	Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)	Homo sapiens (Human)	circadian regulation of gene expression [GO:0032922]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell adhesion [GO:0045785]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of locomotor rhythm [GO:1904059]; regulation of transcription by RNA polymerase II [GO:0006357]; response to transforming growth factor beta [GO:0071559]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000785; GO:0000976; GO:0000978; GO:0000981; GO:0001227; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006355; GO:0006357; GO:0008270; GO:0016604; GO:0019899; GO:0032922; GO:0045662; GO:0045663; GO:0045785; GO:0045893; GO:0045944; GO:0071559; GO:1904059
GN003187	GN003187.1	O73590	39.4	1016	1008	3573	3.60e-160	527	ZFHX4_CHICK	Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) (Zinc finger/apterous-related homeobox protein)	Gallus gallus (Chicken)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0008270
GN003188	GN003188.1	Q8JZL3	38.1	181	410	224	7.65e-25	104	THTPA_MOUSE	Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28)	Mus musculus (Mouse)	dephosphorylation [GO:0016311]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine diphosphate metabolic process [GO:0042357]; thiamine metabolic process [GO:0006772]	magnesium ion binding [GO:0000287]; thiamine triphosphate phosphatase activity [GO:0050333]	cytosol [GO:0005829]	GO:0000287; GO:0005829; GO:0006772; GO:0009229; GO:0016311; GO:0042357; GO:0050333
GN003189	GN003189.1	Q8VYX1	47.5	202	205	498	7.40e-55	184	PEAM1_WHEAT	Phosphoethanolamine N-methyltransferase 1 (TaPEAMT1) (EC 2.1.1.103) (Phosphoethanolamine N-methyltransferase) (WPEAMT)	Triticum aestivum (Wheat)	phosphatidylcholine biosynthetic process [GO:0006656]	phosphoethanolamine N-methyltransferase activity [GO:0000234]		GO:0000234; GO:0006656
GN003190	GN003190.1	Q7TSG2	36.8	600	777	960	1.02e-81	284	CTDP1_MOUSE	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase)	Mus musculus (Mouse)	exit from mitosis [GO:0010458]; host-mediated activation of viral transcription [GO:0043923]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; protein dephosphorylation [GO:0006470]	RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; Tat protein binding [GO:0030957]; TFIIF-class transcription factor complex binding [GO:0001096]	centrosome [GO:0005813]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]	GO:0000922; GO:0001096; GO:0005634; GO:0005654; GO:0005813; GO:0005819; GO:0006470; GO:0008420; GO:0010458; GO:0030496; GO:0030957; GO:0032991; GO:0043923; GO:0051233; GO:0061052
GN003198	GN003198.1	Q8TCF1	44.9	178	705	268	3.42e-42	157	ZFAN1_HUMAN	AN1-type zinc finger protein 1 (Zinc finger AN1-type-containing protein 1)	Homo sapiens (Human)	cellular response to arsenite ion [GO:1903843]; positive regulation of intracellular protein transport [GO:0090316]; stress granule disassembly [GO:0035617]	proteasome binding [GO:0070628]; zinc ion binding [GO:0008270]	cytoplasmic stress granule [GO:0010494]	GO:0008270; GO:0010494; GO:0035617; GO:0070628; GO:0090316; GO:1903843
GN003199	GN003199.1	Q8NA66	27.5	415	506	436	5.79e-33	133	CNBD1_HUMAN	Cyclic nucleotide-binding domain-containing protein 1	Homo sapiens (Human)				
GN003200	GN003200.1	Q28H30	35.3	519	522	440	2.91e-90	286	CE022_XENTR	UPF0489 protein C5orf22 homolog	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)				
GN003201	GN003201.1	P31508	84.5	71	400	81	8.64e-19	83.6	ESCA_APIME	Escargot/snail protein homolog	Apis mellifera (Honeybee)		DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634
GN003206	GN003206.1	Q6YHK3	34.8	1475	1444	1445	2.00e-269	813	CD109_HUMAN	CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)	Homo sapiens (Human)	negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]	endopeptidase inhibitor activity [GO:0004866]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	GO:0004866; GO:0005576; GO:0005886; GO:0009986; GO:0030512; GO:0031092; GO:0061045
GN003208	GN003208.1	P86952	48.4	128	303	456	2.16e-27	114	TYRO_PINMA	Tyrosinase-like protein (Tyrosinase-2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN003209	GN003209.1	P86952	42.1	216	661	456	5.37e-37	147	TYRO_PINMA	Tyrosinase-like protein (Tyrosinase-2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN003225	GN003225.1	Q5R8C8	38.7	106	202	228	5.19e-15	73.9	ANR46_PONAB	Ankyrin repeat domain-containing protein 46	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)			membrane [GO:0016020]	GO:0016020
GN003228	GN003228.1	Q9WV50	76.4	106	108	180	1.69e-57	178	NIP7_RAT	60S ribosome subunit biogenesis protein NIP7 homolog (Nucleolar pre-rRNA processing protein NIP7) (PEachy) (kDa93)	Rattus norvegicus (Rat)	ribosomal large subunit biogenesis [GO:0042273]; ribosome assembly [GO:0042255]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]	GO:0003723; GO:0005730; GO:0030687; GO:0042255; GO:0042273
GN003231	GN003231.1	Q9VQ37	63.4	243	278	365	2.53e-100	300	RIM2_DROME	Mitochondrial carrier protein Rim2	Drosophila melanogaster (Fruit fly)	deoxynucleotide transport [GO:0030302]; pyrimidine nucleotide import into mitochondrion [GO:1990519]	pyrimidine nucleotide transmembrane transporter activity [GO:0015218]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0015218; GO:0030302; GO:1990519
GN003233	GN003233.1	Q9VVE2	31.7	240	573	268	1.67e-30	123	ROGDI_DROME	Protein rogdi	Drosophila melanogaster (Fruit fly)	behavioral response to ethanol [GO:0048149]; gamma-aminobutyric acid secretion, neurotransmission [GO:0061534]; sleep [GO:0030431]		axon [GO:0030424]; dendrite [GO:0030425]; nuclear envelope [GO:0005635]; perikaryon [GO:0043204]; presynapse [GO:0098793]; RAVE complex [GO:0043291]; synaptic vesicle [GO:0008021]	GO:0005635; GO:0008021; GO:0030424; GO:0030425; GO:0030431; GO:0043204; GO:0043291; GO:0048149; GO:0061534; GO:0098793
GN003234	GN003234.1	Q569K6	25.3	677	808	752	7.69e-35	145	CC157_HUMAN	Coiled-coil domain-containing protein 157	Homo sapiens (Human)				
GN003235	GN003235.1	Q5U258	38.9	334	408	443	2.67e-78	251	GCNT3_XENLA	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M)	Xenopus laevis (African clawed frog)		acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0047225]; acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]	Golgi membrane [GO:0000139]	GO:0000139; GO:0003829; GO:0008109; GO:0008375; GO:0047225
GN003236	GN003236.1	B3EWY7	39.3	84	136	359	1.66e-09	57.8	ASOMP_ACRMI	Acidic skeletal organic matrix protein (Acidic SOMP)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]	GO:0005576
GN003238	GN003238.1	P42575	28.3	434	427	452	7.67e-40	151	CASP2_HUMAN	Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]	Homo sapiens (Human)	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; luteolysis [GO:0001554]; negative regulation of apoptotic process [GO:0043066]; neural retina development [GO:0003407]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]	cysteine-type endopeptidase activity [GO:0004197]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0001554; GO:0003407; GO:0004197; GO:0005634; GO:0005730; GO:0005737; GO:0005739; GO:0005829; GO:0006915; GO:0006974; GO:0008630; GO:0016485; GO:0019899; GO:0019904; GO:0030330; GO:0042802; GO:0043065; GO:0043066; GO:0043525; GO:0071260; GO:0097190; GO:0097192; GO:0097194; GO:1905369
GN003241	GN003241.1	Q9UUA2	26.6	354	563	805	2.30e-15	83.2	PIF1_SCHPO	ATP-dependent DNA helicase pfh1 (EC 5.6.2.3) (DNA 5'-3' helicase pfh1) (DNA repair and recombination helicase pfh1) (PIF1 helicase homolog) (RRM3/PIF1 homolog 1)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand elongation involved in mitotic DNA replication [GO:1902983]; mitochondrial DNA repair [GO:0043504]; mitotic recombination-dependent replication fork processing [GO:1990426]; removal of RNA primer involved in mitotic DNA replication [GO:1903469]; replication fork processing [GO:0031297]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; 5'-3' DNA/RNA helicase activity [GO:0033678]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein-DNA complex displacement activity [GO:0061995]; DNA/DNA annealing activity [GO:1990814]; flap-structured DNA binding [GO:0070336]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex unwinding activity [GO:0160225]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]	chromatin [GO:0000785]; chromosome, telomeric repeat region [GO:0140445]; mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; nuclear replisome [GO:0043601]; nucleolus [GO:0005730]; nucleus [GO:0005634]; rDNA heterochromatin [GO:0033553]; site of double-strand break [GO:0035861]	GO:0000723; GO:0000785; GO:0003697; GO:0003723; GO:0005524; GO:0005634; GO:0005730; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0017116; GO:0031297; GO:0033553; GO:0033678; GO:0035861; GO:0043139; GO:0043504; GO:0043596; GO:0043601; GO:0051880; GO:0061995; GO:0070336; GO:0071932; GO:0140445; GO:0160225; GO:1902983; GO:1903469; GO:1990426; GO:1990814
GN003243	GN003243.1	Q95ZS2	53.2	575	562	705	1.86e-215	617	TDC1_CAEEL	Tyrosine decarboxylase (EC 4.1.1.25)	Caenorhabditis elegans	amino acid metabolic process [GO:0006520]; octopamine biosynthetic process [GO:0006589]	pyridoxal phosphate binding [GO:0030170]; tyrosine decarboxylase activity [GO:0004837]	axon [GO:0030424]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]	GO:0004837; GO:0005737; GO:0006520; GO:0006589; GO:0030170; GO:0030424; GO:0043025; GO:0043204
GN003244	GN003244.1	P15101	30.1	306	321	610	1.24e-29	122	DOPO_BOVIN	Dopamine beta-hydroxylase (EC 1.14.17.1) (Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase]	Bos taurus (Bovine)	behavioral response to ethanol [GO:0048149]; dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; positive regulation of cold-induced thermogenesis [GO:0120162]	copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]	chromaffin granule lumen [GO:0034466]; chromaffin granule membrane [GO:0042584]; extracellular region [GO:0005576]; secretory granule lumen [GO:0034774]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]	GO:0004500; GO:0005507; GO:0005576; GO:0030658; GO:0030667; GO:0034466; GO:0034774; GO:0042420; GO:0042421; GO:0042584; GO:0048149; GO:0120162
GN003248	GN003248.1	Q0VD32	66.3	89	106	120	1.35e-29	105	CRBL2_BOVIN	cAMP-responsive element-binding protein-like 2	Bos taurus (Bovine)	positive regulation of D-glucose import across plasma membrane [GO:0046326]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription factor activity [GO:0003700]	nuclear body [GO:0016604]; nucleus [GO:0005634]	GO:0003700; GO:0005634; GO:0006355; GO:0016604; GO:0033138; GO:0045600; GO:0045893; GO:0046326; GO:0046889; GO:0050821
GN003249	GN003249.1	Q90YU6	77.4	93	94	128	1.09e-43	140	RL22_ICTPU	Large ribosomal subunit protein eL22 (60S ribosomal protein L22)	Ictalurus punctatus (Channel catfish) (Silurus punctatus)	cytoplasmic translation [GO:0002181]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; ribosome [GO:0005840]	GO:0002181; GO:0003723; GO:0003735; GO:0005737; GO:0005840
GN003250	GN003250.1	Q5ZMP6	84.9	438	438	433	1.18e-275	754	AP2M1_CHICK	AP-2 complex subunit mu (AP-2 mu chain) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein)	Gallus gallus (Chicken)	clathrin-dependent endocytosis [GO:0072583]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]	clathrin-cargo adaptor activity [GO:0035615]	AP-2 adaptor complex [GO:0030122]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GO:0005829; GO:0005886; GO:0006886; GO:0006896; GO:0008021; GO:0030122; GO:0035615; GO:0072583
GN003251	GN003251.1	B7ZRU9	31.3	684	711	1055	5.62e-20	99.0	EVI1A_XENLA	MDS1 and EVI1 complex locus protein EVI1-A (Ecotropic virus integration site 1 protein homolog-A) (Evi-1) (xEvi-1)	Xenopus laevis (African clawed frog)	negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pronephric distal tubule morphogenesis [GO:0039013]; pronephric duct development [GO:0039022]; pronephros development [GO:0048793]; proximal/distal pattern formation involved in pronephric nephron development [GO:0072196]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0001228; GO:0005634; GO:0006357; GO:0016607; GO:0039013; GO:0039022; GO:0045892; GO:0048793; GO:0072196
GN003254	GN003254.1	Q86Z23	28.6	147	165	238	3.19e-11	62.8	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN003256	GN003256.1	Q99JY3	31.5	162	183	328	6.43e-24	99.0	GIMA4_MOUSE	GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4)	Mus musculus (Mouse)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]	GO:0003924; GO:0005525; GO:0005829
GN003260	GN003260.1	P89116	31.0	258	299	299	3.63e-31	121	CASP1_SPOFR	Caspase-1 (EC 3.4.22.-) [Cleaved into: Caspase-1 subunit p19/18; Caspase-1 subunit p12]	Spodoptera frugiperda (Fall armyworm)	negative regulation of Toll signaling pathway [GO:0045751]; neuron remodeling [GO:0016322]; nurse cell apoptotic process [GO:0045476]; positive regulation of neuron apoptotic process [GO:0043525]; proteolysis [GO:0006508]	BIR domain binding [GO:1990525]; cysteine-type endopeptidase activity [GO:0004197]	cytoplasm [GO:0005737]	GO:0004197; GO:0005737; GO:0006508; GO:0016322; GO:0043525; GO:0045476; GO:0045751; GO:1990525
GN003261	GN003261.1	Q80XI3	49.7	185	317	1579	2.51e-45	168	IF4G3_MOUSE	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII)	Mus musculus (Mouse)	positive regulation of meiosis I [GO:0060903]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; translational initiation [GO:0006413]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; eukaryotic translation initiation factor 4F complex [GO:0016281]; synapse [GO:0045202]	GO:0001934; GO:0003723; GO:0003743; GO:0005737; GO:0006413; GO:0007283; GO:0007286; GO:0016281; GO:0045202; GO:0045727; GO:0060903
GN003263	GN003263.1	P49024	53.8	463	555	559	7.04e-167	488	PAXI_CHICK	Paxillin	Gallus gallus (Chicken)	endothelial cell migration [GO:0043542]; response to muscle stretch [GO:0035994]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]	vinculin binding [GO:0017166]	cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	GO:0001725; GO:0005886; GO:0005911; GO:0005925; GO:0005938; GO:0007179; GO:0017166; GO:0034446; GO:0035994; GO:0043542
GN003269	GN003269.1	G4SLH0	31.0	413	2006	18562	2.02e-39	166	TTN1_CAEEL	Titin homolog (EC 2.7.11.1)	Caenorhabditis elegans		actin filament binding [GO:0051015]; ATP binding [GO:0005524]; myosin binding [GO:0017022]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	A band [GO:0031672]; I band [GO:0031674]; neuron projection [GO:0043005]; nuclear membrane [GO:0031965]	GO:0004674; GO:0005524; GO:0017022; GO:0031672; GO:0031674; GO:0031965; GO:0043005; GO:0051015; GO:0106310
GN003277	GN003277.1	Q61382	46.7	405	515	470	1.39e-141	419	TRAF4_MOUSE	TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich motif associated to RING and Traf domains protein 1)	Mus musculus (Mouse)	cell surface receptor signaling pathway [GO:0007166]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein kinase activity [GO:0045860]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; respiratory gaseous exchange by respiratory system [GO:0007585]; respiratory tube development [GO:0030323]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270]	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0001650; GO:0005164; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005923; GO:0007166; GO:0007585; GO:0008270; GO:0019901; GO:0030323; GO:0031625; GO:0031996; GO:0035591; GO:0042802; GO:0042981; GO:0043122; GO:0043161; GO:0045860; GO:0046330; GO:0048471; GO:0050699; GO:0061630
GN003278	GN003278.1	Q0V9U8	34.1	179	179	376	1.03e-23	99.0	PHIPL_XENTR	Phytanoyl-CoA hydroxylase-interacting protein-like	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			cytoplasm [GO:0005737]	GO:0005737
GN003279	GN003279.1	Q9GLM3	34.3	169	177	1221	8.88e-30	117	RPGR1_BOVIN	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1)	Bos taurus (Bovine)	non-motile cilium assembly [GO:1905515]; retinal rod cell development [GO:0046548]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; photoreceptor connecting cilium [GO:0032391]	GO:0005737; GO:0005856; GO:0032391; GO:0046548; GO:1905515
GN003281	GN003281.1	Q9D404	56.2	418	426	459	5.39e-154	446	OXSM_MOUSE	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase)	Mus musculus (Mouse)	acyl-CoA metabolic process [GO:0006637]; medium-chain fatty acid biosynthetic process [GO:0051792]; short-chain fatty acid biosynthetic process [GO:0051790]	3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0004315; GO:0005739; GO:0005829; GO:0006637; GO:0051790; GO:0051792
GN003282	GN003282.1	Q148G5	50.7	349	376	593	1.49e-106	328	PROD_BOVIN	Proline dehydrogenase 1, mitochondrial (EC 1.5.5.2) (Proline oxidase)	Bos taurus (Bovine)	L-proline catabolic process [GO:0006562]	FAD binding [GO:0071949]; proline dehydrogenase activity [GO:0004657]	mitochondrial matrix [GO:0005759]	GO:0004657; GO:0005759; GO:0006562; GO:0071949
GN003283	GN003283.1	Q5ZIJ9	60.4	785	782	954	2.01e-215	635	MIB2_CHICK	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (RING-type E3 ubiquitin transferase MIB2)	Gallus gallus (Chicken)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN003286	GN003286.1	Q5U379	63.9	133	164	373	2.49e-54	178	SNF5_DANRE	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1-A	Danio rerio (Zebrafish) (Brachydanio rerio)	chromatin remodeling [GO:0006338]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]	brahma complex [GO:0035060]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear chromosome [GO:0000228]	GO:0000228; GO:0003677; GO:0003713; GO:0006338; GO:0006357; GO:0035060; GO:0071564; GO:0071565
GN003288	GN003288.1	Q8BJ64	64.7	569	1191	596	1.36e-262	757	CHDH_MOUSE	Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)	Mus musculus (Mouse)	glycine betaine biosynthetic process from choline [GO:0019285]	choline dehydrogenase activity [GO:0008812]; flavin adenine dinucleotide binding [GO:0050660]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0005739; GO:0005741; GO:0005743; GO:0008812; GO:0019285; GO:0050660
GN003289	GN003289.1	Q8CA72	37.2	395	398	597	1.41e-15	82.0	GAN_MOUSE	Gigaxonin	Mus musculus (Mouse)	cytoskeleton organization [GO:0007010]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]	GO:0005737; GO:0007010; GO:0015630; GO:0016567; GO:0031463; GO:0043161; GO:1990756
GN003290	GN003290.1	Q5ZJX5	39.7	385	385	468	1.29e-78	252	MEAK7_CHICK	MTOR-associated protein MEAK7 (MEAK7) (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1)	Gallus gallus (Chicken)	positive regulation of protein localization to lysosome [GO:0150032]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; response to amino acid [GO:0043200]; response to insulin [GO:0032868]; response to nutrient levels [GO:0031667]; response to oxidative stress [GO:0006979]; TOR signaling [GO:0031929]		cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005764; GO:0005765; GO:0006979; GO:0016020; GO:0030334; GO:0031667; GO:0031929; GO:0032868; GO:0042127; GO:0043200; GO:0150032
GN003291	GN003291.1	Q1RMU2	30.1	611	643	953	3.90e-60	220	CYLD_BOVIN	Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)	Bos taurus (Bovine)	innate immune response [GO:0045087]; necroptotic process [GO:0070266]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-18-mediated signaling pathway [GO:2000493]; negative regulation of JNK cascade [GO:0046329]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of p38MAPK cascade [GO:1903753]; protein deubiquitination [GO:0016579]; protein K63-linked deubiquitination [GO:0070536]; protein linear deubiquitination [GO:1990108]; regulation of cilium assembly [GO:1902017]; regulation of inflammatory response [GO:0050727]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; regulation of mitotic cell cycle [GO:0007346]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]	cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819]	GO:0004843; GO:0005813; GO:0005819; GO:0005829; GO:0005886; GO:0007346; GO:0008270; GO:0010803; GO:0016579; GO:0036064; GO:0043124; GO:0045087; GO:0046329; GO:0048471; GO:0050727; GO:0050728; GO:0061578; GO:0070266; GO:0070536; GO:0090090; GO:0097542; GO:1901223; GO:1902017; GO:1903753; GO:1990108; GO:2000493; GO:2001242
GN003292	GN003292.1	Q6PGU2	57.4	195	206	247	1.80e-66	207	MAF1_DANRE	Repressor of RNA polymerase III transcription MAF1 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	negative regulation of transcription by RNA polymerase III [GO:0016480]	RNA polymerase III core binding [GO:0000994]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000994; GO:0005634; GO:0005737; GO:0016480
GN003298	GN003298.1	Q0P5H9	51.9	335	335	440	1.18e-113	339	TTC5_BOVIN	Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Protein Strap)	Bos taurus (Bovine)	cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; positive regulation of RNA metabolic process [GO:0051254]; regulation of gene expression [GO:0010468]		cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006974; GO:0009267; GO:0010468; GO:0031410; GO:0051254
GN003299	GN003299.1	Q53G44	37.6	234	471	452	3.80e-42	158	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN003303	GN003303.1	A4IF63	20.7	518	675	744	1.09e-23	110	TRIM2_BOVIN	Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2)	Bos taurus (Bovine)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0043161; GO:0043523; GO:0061630
GN003304	GN003304.1	P58197	69.7	208	436	437	2.19e-90	283	AP2A_RAT	Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)	Rattus norvegicus (Rat)	anterior neuropore closure [GO:0021506]; basement membrane organization [GO:0071711]; bone morphogenesis [GO:0060349]; cellular response to iron ion [GO:0071281]; cornea development in camera-type eye [GO:0061303]; embryonic body morphogenesis [GO:0010172]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; embryonic pattern specification [GO:0009880]; epidermis morphogenesis [GO:0048730]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; forebrain neuron development [GO:0021884]; forelimb morphogenesis [GO:0035136]; inner ear morphogenesis [GO:0042472]; keratinocyte development [GO:0003334]; kidney development [GO:0001822]; lens induction in camera-type eye [GO:0060235]; lens morphogenesis in camera-type eye [GO:0002089]; metanephric nephron development [GO:0072210]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell development [GO:0014032]; neural tube closure [GO:0001843]; oculomotor nerve formation [GO:0021623]; optic cup structural organization [GO:0003409]; optic vesicle morphogenesis [GO:0003404]; outflow tract morphogenesis [GO:0003151]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron differentiation [GO:0045664]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; retina layer formation [GO:0010842]; roof of mouth development [GO:0060021]; Schwann cell development [GO:0014044]; sensory organ development [GO:0007423]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; sympathetic nervous system development [GO:0048485]; trigeminal nerve development [GO:0021559]	chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]	clathrin-coated pit [GO:0005905]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0000987; GO:0001227; GO:0001228; GO:0001501; GO:0001822; GO:0001843; GO:0002089; GO:0003151; GO:0003334; GO:0003404; GO:0003409; GO:0003677; GO:0003682; GO:0003700; GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0005905; GO:0006355; GO:0006357; GO:0007399; GO:0007423; GO:0007605; GO:0008285; GO:0009880; GO:0010172; GO:0010628; GO:0010842; GO:0014032; GO:0014044; GO:0021506; GO:0021559; GO:0021623; GO:0021884; GO:0030335; GO:0030501; GO:0032496; GO:0035115; GO:0035136; GO:0042059; GO:0042127; GO:0042472; GO:0042802; GO:0043066; GO:0043524; GO:0043525; GO:0043565; GO:0043588; GO:0045595; GO:0045664; GO:0045892; GO:0045893; GO:0045944; GO:0048485; GO:0048596; GO:0048701; GO:0048705; GO:0048730; GO:0060021; GO:0060235; GO:0060325; GO:0060349; GO:0061029; GO:0061303; GO:0070172; GO:0071281; GO:0071711; GO:0072210; GO:0140416; GO:1990837; GO:2000378
GN003306	GN003306.1	P06734	36.5	126	255	321	6.44e-18	84.7	FCER2_HUMAN	Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form]	Homo sapiens (Human)	B cell antigen processing and presentation [GO:0002450]; defense response to bacterium [GO:0042742]; Fc receptor-mediated immune complex endocytosis [GO:0160006]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immune response [GO:0006955]; macrophage activation [GO:0042116]; positive regulation of gene expression [GO:0010628]	carbohydrate binding [GO:0030246]; IgE binding [GO:0019863]; integrin binding [GO:0005178]; low-affinity IgE receptor activity [GO:0019769]; pattern recognition receptor activity [GO:0038187]; protease binding [GO:0002020]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0002020; GO:0002450; GO:0005178; GO:0005576; GO:0005886; GO:0006955; GO:0009897; GO:0010628; GO:0019769; GO:0019863; GO:0030246; GO:0038096; GO:0038187; GO:0042116; GO:0042742; GO:0070062; GO:0160006
GN003311	GN003311.1	Q6AZB8	35.0	246	289	349	1.19e-42	152	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN003312	GN003312.1	Q28J92	34.7	124	237	365	7.78e-14	73.2	MSD3_XENTR	Myb/SANT-like DNA-binding domain-containing protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)				
GN003317	GN003317.1	Q6GNG8	58.5	94	176	173	4.78e-28	105	PKRI1_XENLA	PRKR-interacting protein 1 homolog	Xenopus laevis (African clawed frog)		double-stranded RNA binding [GO:0003725]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]	nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003725; GO:0004860; GO:0005634; GO:0005730; GO:0019901
GN003320	GN003320.1	Q21268	33.2	238	261	290	3.57e-28	112	YMSO_CAEEL	UPF0046 protein K07C11.7	Caenorhabditis elegans		cyclic-nucleotide phosphodiesterase activity [GO:0004112]		GO:0004112
GN003321	GN003321.1	P17972	32.4	423	444	498	1.87e-61	210	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN003322	GN003322.1	P17972	32.0	422	444	498	1.00e-60	208	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN003323	GN003323.1	P17972	31.4	423	444	498	2.74e-60	207	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN003324	GN003324.1	P17972	36.6	164	155	498	1.95e-26	106	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN003325	GN003325.1	Q21268	33.7	163	229	290	2.43e-17	82.0	YMSO_CAEEL	UPF0046 protein K07C11.7	Caenorhabditis elegans		cyclic-nucleotide phosphodiesterase activity [GO:0004112]		GO:0004112
GN003326	GN003326.1	Q20191	55.9	161	364	450	1.43e-49	175	NAS13_CAEEL	Zinc metalloproteinase nas-13 (EC 3.4.24.-) (Nematode astacin 13)	Caenorhabditis elegans	proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0004222; GO:0005576; GO:0006508; GO:0008270
GN003327	GN003327.1	Q96DF8	37.8	156	179	476	2.05e-19	87.8	ESS2_HUMAN	Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2)	Homo sapiens (Human)	mRNA splicing, via spliceosome [GO:0000398]; nervous system development [GO:0007399]		catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]	GO:0000398; GO:0005634; GO:0007399; GO:0071013
GN003328	GN003328.1	Q96DF8	49.2	305	309	476	7.63e-75	240	ESS2_HUMAN	Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2)	Homo sapiens (Human)	mRNA splicing, via spliceosome [GO:0000398]; nervous system development [GO:0007399]		catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]	GO:0000398; GO:0005634; GO:0007399; GO:0071013
GN003329	GN003329.1	Q7SYB5	26.5	317	705	612	8.17e-23	107	DEFI6_DANRE	Differentially expressed in FDCP 6 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	cell migration involved in gastrulation [GO:0042074]; convergent extension [GO:0060026]; convergent extension involved in gastrulation [GO:0060027]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0042074; GO:0060026; GO:0060027
GN003330	GN003330.1	Q4V7W8	48.1	212	242	246	5.60e-67	210	ETKMT_XENLA	Electron transfer flavoprotein beta subunit lysine methyltransferase (EC 2.1.1.-) (ETFB lysine methyltransferase) (ETFB-KMT) (Protein N-lysine methyltransferase METTL20)	Xenopus laevis (African clawed frog)	negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:1904736]	protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]	GO:0005737; GO:0005759; GO:0016279; GO:1904736
GN003331	GN003331.1	Q5FWL3	38.2	170	275	317	2.12e-30	119	RNF41_XENLA	E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)	Xenopus laevis (African clawed frog)	extrinsic apoptotic signaling pathway [GO:0097191]; protein polyubiquitination [GO:0000209]; regulation of canonical NF-kappaB signal transduction [GO:0043122]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]		GO:0000209; GO:0004842; GO:0043122; GO:0061630; GO:0097191
GN003334	GN003334.1	Q9NRA2	35.4	401	580	495	1.20e-76	254	S17A5_HUMAN	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)	Homo sapiens (Human)	carbohydrate derivative transport [GO:1901264]; monoatomic anion transport [GO:0006820]; neurotransmitter loading into synaptic vesicle [GO:0098700]; sialic acid transport [GO:0015739]	carbohydrate:proton symporter activity [GO:0005351]; D-glucuronate transmembrane transporter activity [GO:0042880]; glucuronate transmembrane transporter activity [GO:0015135]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	GO:0005351; GO:0005764; GO:0005765; GO:0005886; GO:0006820; GO:0015135; GO:0015136; GO:0015538; GO:0015739; GO:0016020; GO:0016323; GO:0016324; GO:0030672; GO:0042880; GO:0098700; GO:0098978; GO:1901264
GN003335	GN003335.1	Q03567	34.0	456	679	493	3.96e-77	258	SL172_CAEEL	Uncharacterized transporter slc-17.2	Caenorhabditis elegans		transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0016020; GO:0022857
GN003336	GN003336.1	Q9NRA2	30.4	388	664	495	5.40e-55	198	S17A5_HUMAN	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)	Homo sapiens (Human)	carbohydrate derivative transport [GO:1901264]; monoatomic anion transport [GO:0006820]; neurotransmitter loading into synaptic vesicle [GO:0098700]; sialic acid transport [GO:0015739]	carbohydrate:proton symporter activity [GO:0005351]; D-glucuronate transmembrane transporter activity [GO:0042880]; glucuronate transmembrane transporter activity [GO:0015135]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	GO:0005351; GO:0005764; GO:0005765; GO:0005886; GO:0006820; GO:0015135; GO:0015136; GO:0015538; GO:0015739; GO:0016020; GO:0016323; GO:0016324; GO:0030672; GO:0042880; GO:0098700; GO:0098978; GO:1901264
GN003337	GN003337.1	Q7RTV5	44.4	189	231	226	2.00e-54	177	PXL2C_HUMAN	Peroxiredoxin-like 2C (AhpC/TSA antioxidant enzyme domain-containing protein 1) (Thioredoxin-like protein AAED1)	Homo sapiens (Human)	positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glycolytic process [GO:0045821]			GO:0045821; GO:0070374
GN003341	GN003341.1	Q57951	30.1	143	170	170	1.02e-09	57.8	Y531_METJA	Universal stress protein MJ0531 (USP MJ0531)	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)				
GN003342	GN003342.1	Q96PB7	34.5	287	456	478	2.42e-44	164	NOE3_HUMAN	Noelin-3 (Olfactomedin-3) (Optimedin)	Homo sapiens (Human)	eye photoreceptor cell development [GO:0042462]; signal transduction [GO:0007165]		AMPA glutamate receptor complex [GO:0032281]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; synapse [GO:0045202]	GO:0005576; GO:0005794; GO:0007165; GO:0032281; GO:0042462; GO:0045202
GN003343	GN003343.1	A4FUP9	30.8	341	292	346	6.98e-50	171	GL1D1_MOUSE	Glycosyltransferase 1 domain-containing protein 1 (EC 2.4.-.-)	Mus musculus (Mouse)		glycosyltransferase activity [GO:0016757]	cytosol [GO:0005829]; extracellular region [GO:0005576]	GO:0005576; GO:0005829; GO:0016757
GN003347	GN003347.1	A0A1L8HFX9	57.5	268	1595	980	2.67e-84	302	G2L2L_XENLA	GAS2-like protein 2A (growth arrest specific 2 like 2 A)	Xenopus laevis (African clawed frog)	actin crosslink formation [GO:0051764]; microtubule bundle formation [GO:0001578]; protein localization to microtubule plus-end [GO:1904825]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of microtubule polymerization or depolymerization [GO:0031110]	actin filament binding [GO:0051015]; cytoskeletal adaptor activity [GO:0008093]; microtubule binding [GO:0008017]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; microtubule plus-end [GO:0035371]; stress fiber [GO:0001725]	GO:0001578; GO:0001725; GO:0005737; GO:0005884; GO:0008017; GO:0008093; GO:0031110; GO:0035371; GO:0051015; GO:0051764; GO:0060296; GO:1904825
GN003348	GN003348.1	O88627	41.7	516	600	660	7.34e-116	362	S28A2_MOUSE	Sodium/nucleoside cotransporter 2 (Concentrative nucleoside transporter 2) (CNT 2) (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Sodium/purine nucleoside cotransporter) (SPNT) (Solute carrier family 28 member 2)	Mus musculus (Mouse)	adenosine transport [GO:0032238]; inosine transport [GO:0035340]; neurotransmitter transport [GO:0006836]; nucleoside transmembrane transport [GO:1901642]; purine nucleobase transmembrane transport [GO:1904823]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine-containing compound transmembrane transport [GO:0072531]; retina homeostasis [GO:0001895]; uridine transmembrane transport [GO:0015862]	neurotransmitter transmembrane transporter activity [GO:0005326]; nucleoside transmembrane transporter activity [GO:0005337]; nucleoside:sodium symporter activity [GO:0005415]; purine nucleobase transmembrane transporter activity [GO:0005345]; purine nucleoside transmembrane transporter activity [GO:0015211]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]; uridine transmembrane transporter activity [GO:0015213]	apicolateral plasma membrane [GO:0016327]; brush border membrane [GO:0031526]; coated vesicle [GO:0030135]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]	GO:0001895; GO:0005326; GO:0005337; GO:0005345; GO:0005415; GO:0005886; GO:0006836; GO:0012506; GO:0015211; GO:0015213; GO:0015389; GO:0015860; GO:0015862; GO:0016020; GO:0016327; GO:0030135; GO:0031526; GO:0032238; GO:0035340; GO:0072531; GO:1901642; GO:1904823
GN003349	GN003349.1	P42577	78.4	167	171	174	8.02e-90	262	FRIS_LYMST	Soma ferritin (EC 1.16.3.1)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]	ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]	cytoplasm [GO:0005737]	GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008198; GO:0008199
GN003354	GN003354.1	P17972	33.5	173	290	498	4.27e-27	113	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN003355	GN003355.1	P17972	44.7	206	273	498	8.97e-51	176	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN003357	GN003357.1	Q9UA35	45.4	416	457	683	1.04e-123	378	S28A3_EPTST	Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT)	Eptatretus stoutii (Pacific hagfish)	purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]	purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]	plasma membrane [GO:0005886]	GO:0005886; GO:0015389; GO:0015390; GO:0015860; GO:0015864
GN003358	GN003358.1	P79987	35.4	615	612	1019	2.71e-86	293	HIRA_CHICK	Protein HIRA (cHIRA) (TUP1-like enhancer of split protein 1)	Gallus gallus (Chicken)	chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; regulation of DNA-templated transcription [GO:0006355]		HIR complex [GO:0000417]; nucleus [GO:0005634]	GO:0000417; GO:0005634; GO:0006338; GO:0006351; GO:0006355
GN003359	GN003359.1	O42611	42.4	66	123	1025	2.80e-10	59.7	HIRA_TAKRU	Protein HIRA (TUP1-like enhancer of split protein 1)	Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)	chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; regulation of DNA-templated transcription [GO:0006355]	nucleosome binding [GO:0031491]	chromatin [GO:0000785]; HIR complex [GO:0000417]; nucleus [GO:0005634]	GO:0000417; GO:0000785; GO:0005634; GO:0006338; GO:0006351; GO:0006355; GO:0031491
GN003362	GN003362.1	Q61666	72.9	70	76	1015	6.05e-33	122	HIRA_MOUSE	Protein HIRA (TUP1-like enhancer of split protein 1)	Mus musculus (Mouse)	gastrulation [GO:0007369]; muscle cell differentiation [GO:0042692]; osteoblast differentiation [GO:0001649]; regulation of DNA-templated transcription [GO:0006355]; transcription elongation-coupled chromatin remodeling [GO:0140673]	histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	chromatin [GO:0000785]; HIR complex [GO:0000417]; nucleoplasm [GO:0005654]; PML body [GO:0016605]; protein-containing complex [GO:0032991]	GO:0000417; GO:0000785; GO:0001649; GO:0005654; GO:0006355; GO:0007369; GO:0016605; GO:0032991; GO:0042393; GO:0042692; GO:0061629; GO:0140673; GO:0140713
GN003369	GN003369.1	Q9VR07	48.4	550	586	943	4.61e-197	580	INE_DROME	Sodium- and chloride-dependent GABA transporter ine (Protein inebriated) (Protein receptor oscillation A)	Drosophila melanogaster (Fruit fly)	glial cell growth [GO:0042065]; glycine import across plasma membrane [GO:1903804]; multicellular organismal-level water homeostasis [GO:0050891]; neurotransmitter transport [GO:0006836]; perineurial glial growth [GO:0042066]; regulation of response to osmotic stress [GO:0047484]; response to water deprivation [GO:0009414]; sodium ion transmembrane transport [GO:0035725]; transmission of nerve impulse [GO:0019226]	amino acid:sodium symporter activity [GO:0005283]; neurotransmitter:sodium symporter activity [GO:0005328]; osmosensor activity [GO:0005034]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005034; GO:0005283; GO:0005328; GO:0005886; GO:0006836; GO:0009414; GO:0016020; GO:0016323; GO:0019226; GO:0035725; GO:0042065; GO:0042066; GO:0047484; GO:0050891; GO:1903804
GN003370	GN003370.1	Q86TD4	28.6	248	490	473	3.06e-09	62.8	SRCA_HUMAN	Sarcalumenin	Homo sapiens (Human)	store-operated calcium entry [GO:0002115]	GTP binding [GO:0005525]	sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]	GO:0002115; GO:0005525; GO:0033017; GO:0033018
GN003372	GN003372.1	Q9VF27	76.2	185	210	217	1.12e-76	232	NDUS8_DROME	NADH dehydrogenase (ubiquinone) 23 kDa subunit (EC 7.1.1.2)	Drosophila melanogaster (Fruit fly)	mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]	4 iron, 4 sulfur cluster binding [GO:0051539]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271]	GO:0005739; GO:0005743; GO:0006120; GO:0008137; GO:0032981; GO:0042775; GO:0045271; GO:0051539
GN003373	GN003373.1	Q6DIM3	51.9	455	445	451	1.32e-172	494	TBD_XENTR	Tubulin delta chain (Delta-tubulin)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; positive regulation of smoothened signaling pathway [GO:0045880]	GTP binding [GO:0005525]; structural constituent of cytoskeleton [GO:0005200]	centriole [GO:0005814]; cilium [GO:0005929]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]	GO:0000278; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005814; GO:0005874; GO:0005929; GO:0007017; GO:0045880
GN003376	GN003376.1	Q8N5N7	32.4	102	226	158	6.42e-14	70.1	RM50_HUMAN	Large ribosomal subunit protein mL50 (39S ribosomal protein L50, mitochondrial) (L50mt) (MRP-L50)	Homo sapiens (Human)	mitochondrial translation [GO:0032543]		mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0005762; GO:0032543
GN003377	GN003377.1	A4FU69	35.5	1336	1522	1503	6.61e-180	581	EFCB5_HUMAN	EF-hand calcium-binding domain-containing protein 5	Homo sapiens (Human)		calcium ion binding [GO:0005509]		GO:0005509
GN003378	GN003378.1	Q16534	45.8	275	261	295	5.05e-54	179	HLF_HUMAN	Transcription factor HLF (Hepatic leukemia factor)	Homo sapiens (Human)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0003690; GO:0005634; GO:0005654; GO:0006357; GO:0043565; GO:0045944; GO:0046982; GO:0090575; GO:1990837
GN003381	GN003381.1	A4FU69	35.5	1304	1277	1503	7.16e-172	553	EFCB5_HUMAN	EF-hand calcium-binding domain-containing protein 5	Homo sapiens (Human)		calcium ion binding [GO:0005509]		GO:0005509
GN003382	GN003382.1	Q9DAG6	31.2	125	207	236	5.28e-10	60.5	GPRL1_MOUSE	GLIPR1-like protein 1	Mus musculus (Mouse)	binding of sperm to zona pellucida [GO:0007339]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; protein localization involved in acrosome reaction [GO:0060476]	molecular adaptor activity [GO:0060090]	acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; outer acrosomal membrane [GO:0002081]; plasma membrane [GO:0005886]; protein complex involved in cell-cell adhesion [GO:0098635]; sperm head-tail coupling apparatus [GO:0120212]	GO:0001669; GO:0002081; GO:0005576; GO:0005886; GO:0007339; GO:0007342; GO:0045121; GO:0060090; GO:0060476; GO:0098635; GO:0120212
GN003386	GN003386.1	P9WEL6	25.3	269	332	308	2.91e-15	78.6	AVAO_ASPVE	Ava biosynthesis cluster protein O	Aspergillus versicolor				
GN003391	GN003391.1	P18293	45.6	195	625	1057	1.30e-42	168	ANPRA_MOUSE	Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)	Mus musculus (Mouse)	cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	ANPR-A receptor complex [GO:1990620]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005789; GO:0005886; GO:0006182; GO:0007166; GO:0007168; GO:0008217; GO:0016020; GO:0016941; GO:0017046; GO:0031965; GO:0035556; GO:0042417; GO:0042562; GO:0043114; GO:0043235; GO:0048662; GO:1990620
GN003392	GN003392.1	E0W1I1	34.0	580	657	575	8.66e-87	285	PINK1_PEDHC	Serine/threonine-protein kinase Pink1, mitochondrial (EC 2.7.11.1) (PTEN-induced putative kinase 1)	Pediculus humanus subsp. corporis (Body louse)	autophagy of mitochondrion [GO:0000422]; positive regulation of mitochondrial fission [GO:0090141]; regulation of apoptotic process [GO:0042981]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]	GO:0000422; GO:0004672; GO:0004674; GO:0005524; GO:0005741; GO:0005743; GO:0005829; GO:0042981; GO:0090141; GO:0106310
GN003399	GN003399.1	Q9NQQ7	56.9	313	384	365	1.08e-114	341	S35H1_HUMAN	Solute carrier family 35 member H1 (Ovarian cancer-overexpressed gene 1 protein) (Solute carrier family 35 member C2)	Homo sapiens (Human)	UDP-glucose transmembrane transport [GO:0015786]		cis-Golgi network [GO:0005801]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]	GO:0005793; GO:0005794; GO:0005801; GO:0015786; GO:0033116
GN003401	GN003401.1	Q0P570	54.5	389	398	400	3.72e-140	408	MVD1_BOVIN	Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase)	Bos taurus (Bovine)	cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; isoprenoid biosynthetic process [GO:0008299]; positive regulation of cell population proliferation [GO:0008284]	diphosphomevalonate decarboxylase activity [GO:0004163]; Hsp70 protein binding [GO:0030544]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004163; GO:0005737; GO:0005829; GO:0006695; GO:0008284; GO:0008299; GO:0019287; GO:0030544; GO:0042803
GN003406	GN003406.1	Q8C3P7	72.5	320	558	580	3.98e-180	523	MTA70_MOUSE	N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70)	Mus musculus (Mouse)	cellular response to UV [GO:0034644]; chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; dosage compensation by inactivation of X chromosome [GO:0009048]; endothelial to hematopoietic transition [GO:0098508]; forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; mRNA export from nucleus [GO:0006406]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; oogenesis [GO:0048477]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of translation [GO:0045727]; primary miRNA processing [GO:0031053]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of meiotic cell cycle [GO:0051445]; regulation of T cell differentiation [GO:0045580]; RNA methylation [GO:0001510]; RNA stabilization [GO:0043489]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827]	mRNA binding [GO:0003729]; mRNA m(6)A methyltransferase activity [GO:0001734]; protein heterodimerization activity [GO:0046982]; RNA methyltransferase activity [GO:0008173]; S-adenosyl-L-methionine binding [GO:1904047]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	GO:0000398; GO:0001510; GO:0001734; GO:0003729; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006397; GO:0006402; GO:0006406; GO:0006974; GO:0007283; GO:0007623; GO:0008173; GO:0009048; GO:0016556; GO:0016604; GO:0016607; GO:0019827; GO:0021861; GO:0031053; GO:0034644; GO:0036396; GO:0042063; GO:0043489; GO:0045580; GO:0045727; GO:0045746; GO:0046982; GO:0048477; GO:0051445; GO:0060339; GO:0061014; GO:0061157; GO:0098508; GO:0141119; GO:1902036; GO:1903679; GO:1904047
GN003407	GN003407.1	Q99M85	37.2	298	308	348	4.82e-44	156	SCRT1_MOUSE	Transcriptional repressor scratch 1 (Scratch homolog 1 zinc finger protein) (SCRT) (Scratch 1) (mScrt)	Mus musculus (Mouse)	negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron migration [GO:2001222]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	nuclear body [GO:0016604]; nucleus [GO:0005634]	GO:0000122; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0005634; GO:0006355; GO:0016604; GO:0043565; GO:1990837; GO:2001222
GN003410	GN003410.1	Q5AXT5	29.1	409	967	745	9.71e-36	149	PIF1_EMENI	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]	GO:0000723; GO:0003697; GO:0005524; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0043139; GO:0043596; GO:0071932
GN003412	GN003412.1	P86786	68.9	225	586	284	3.18e-102	313	GIGA3_MAGGI	Gigasin-3a	Magallana gigas (Pacific oyster) (Crassostrea gigas)				
GN003413	GN003413.1	P86786	47.6	124	137	284	3.47e-34	123	GIGA3_MAGGI	Gigasin-3a	Magallana gigas (Pacific oyster) (Crassostrea gigas)				
GN003414	GN003414.1	P86786	50.0	202	536	284	1.36e-61	207	GIGA3_MAGGI	Gigasin-3a	Magallana gigas (Pacific oyster) (Crassostrea gigas)				
GN003416	GN003416.1	Q5R9F5	43.7	419	453	462	3.24e-110	336	S38A7_PONAB	Sodium-coupled neutral amino acid transporter 7 (Solute carrier family 38 member 7)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	asparagine transport [GO:0006867]; L-glutamine transport [GO:0006868]; sodium ion transport [GO:0006814]	L-asparagine:sodium symporter activity [GO:0140901]; L-glutamine:sodium symporter activity [GO:0140902]	axon [GO:0030424]; lysosomal membrane [GO:0005765]; neuronal cell body [GO:0043025]	GO:0005765; GO:0006814; GO:0006867; GO:0006868; GO:0030424; GO:0043025; GO:0140901; GO:0140902
GN003417	GN003417.1	P86786	68.9	225	586	284	3.18e-102	313	GIGA3_MAGGI	Gigasin-3a	Magallana gigas (Pacific oyster) (Crassostrea gigas)				
GN003419	GN003419.1	Q9P104	30.6	180	194	306	1.22e-16	79.3	DOK5_HUMAN	Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)	Homo sapiens (Human)	cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]	signaling adaptor activity [GO:0035591]	cytosol [GO:0005829]	GO:0005829; GO:0007169; GO:0035591; GO:0051386
GN003420	GN003420.1	Q6DFL0	43.5	386	409	524	3.15e-73	241	C102A_XENLA	Coiled-coil domain-containing protein 102A	Xenopus laevis (African clawed frog)			myosin complex [GO:0016459]	GO:0016459
GN003421	GN003421.1	Q921F2	56.9	341	402	414	4.66e-125	370	TADBP_MOUSE	TAR DNA-binding protein 43 (TDP-43)	Mus musculus (Mouse)	3'-UTR-mediated mRNA destabilization [GO:0061158]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; amyloid fibril formation [GO:1990000]; gene expression [GO:0010467]; host-mediated suppression of viral transcription [GO:0043922]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; nuclear inner membrane organization [GO:0071765]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein import into nucleus [GO:0042307]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976]; RNA splicing [GO:0008380]	DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; molecular condensate scaffold activity [GO:0140693]; mRNA 3'-UTR binding [GO:0003730]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; interchromatin granule [GO:0035061]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]	GO:0000785; GO:0000978; GO:0001933; GO:0003677; GO:0003690; GO:0003723; GO:0003730; GO:0005634; GO:0005654; GO:0005726; GO:0005737; GO:0005739; GO:0008289; GO:0008380; GO:0010467; GO:0010468; GO:0010494; GO:0010629; GO:0016607; GO:0031647; GO:0032024; GO:0034976; GO:0035061; GO:0042307; GO:0042752; GO:0042802; GO:0042981; GO:0043922; GO:0051726; GO:0061158; GO:0070935; GO:0071765; GO:0097157; GO:0140693; GO:1990000
GN003424	GN003424.1	Q19673	34.3	248	724	693	6.35e-36	148	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN003425	GN003425.1	H2A0L1	36.3	248	564	456	5.64e-35	140	TYRO2_PINMG	Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2)	Margaritifera margaritifera (Freshwater pearl mussel)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN003426	GN003426.1	Q19673	32.7	220	509	693	1.40e-23	108	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN003447	GN003447.1	Q15070	38.7	305	436	435	1.21e-57	198	OXA1L_HUMAN	Mitochondrial inner membrane protein OXA1L (OXA1Hs) (Oxidase assembly 1-like protein) (OXA1-like protein)	Homo sapiens (Human)	aerobic respiration [GO:0009060]; mitochondrial protein quality control [GO:0141164]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrial translation [GO:0032543]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of oxidoreductase activity [GO:0051354]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein tetramerization [GO:0051262]	membrane insertase activity [GO:0032977]; mitochondrial ribosome binding [GO:0097177]; protein homodimerization activity [GO:0042803]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	GO:0005739; GO:0005743; GO:0005759; GO:0009060; GO:0031966; GO:0032543; GO:0032780; GO:0032977; GO:0032979; GO:0032981; GO:0032991; GO:0033615; GO:0042803; GO:0051262; GO:0051354; GO:0097177; GO:0141164
GN003449	GN003449.1	Q5U3I2	25.2	329	382	326	5.51e-12	69.7	S7A6O_DANRE	Probable RNA polymerase II nuclear localization protein SLC7A6OS (Solute carrier family 7 member 6 opposite strand transcript homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	central nervous system development [GO:0007417]; developmental process [GO:0032502]; midbrain-hindbrain boundary structural organization [GO:0021552]; somite development [GO:0061053]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0007417; GO:0021552; GO:0032502; GO:0061053
GN003453	GN003453.1	Q08BG1	49.4	271	277	437	2.73e-92	282	TMPPE_DANRE	Transmembrane protein with metallophosphoesterase domain (EC 3.1.-.-)	Danio rerio (Zebrafish) (Brachydanio rerio)		hydrolase activity [GO:0016787]	membrane [GO:0016020]	GO:0016020; GO:0016787
GN003454	GN003454.1	O75131	54.9	532	545	537	1.50e-201	575	CPNE3_HUMAN	Copine-3 (Copine III)	Homo sapiens (Human)	cellular response to calcium ion [GO:0071277]; cellular response to growth factor stimulus [GO:0071363]; ERBB2 signaling pathway [GO:0038128]; glycerophospholipid biosynthetic process [GO:0046474]; positive regulation of cell migration [GO:0030335]	calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; protein serine/threonine kinase activity [GO:0004674]; protein-membrane adaptor activity [GO:0043495]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]	anchoring junction [GO:0070161]; azurophil granule membrane [GO:0035577]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0003723; GO:0004674; GO:0005544; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0005925; GO:0030054; GO:0030335; GO:0030971; GO:0035577; GO:0038128; GO:0043495; GO:0046474; GO:0048306; GO:0070062; GO:0070161; GO:0071277; GO:0071363
GN003455	GN003455.1	O75131	49.1	568	578	537	3.33e-181	525	CPNE3_HUMAN	Copine-3 (Copine III)	Homo sapiens (Human)	cellular response to calcium ion [GO:0071277]; cellular response to growth factor stimulus [GO:0071363]; ERBB2 signaling pathway [GO:0038128]; glycerophospholipid biosynthetic process [GO:0046474]; positive regulation of cell migration [GO:0030335]	calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; protein serine/threonine kinase activity [GO:0004674]; protein-membrane adaptor activity [GO:0043495]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]	anchoring junction [GO:0070161]; azurophil granule membrane [GO:0035577]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0003723; GO:0004674; GO:0005544; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0005925; GO:0030054; GO:0030335; GO:0030971; GO:0035577; GO:0038128; GO:0043495; GO:0046474; GO:0048306; GO:0070062; GO:0070161; GO:0071277; GO:0071363
GN003456	GN003456.1	Q5RGB8	32.2	599	599	605	2.43e-95	307	KLH26_DANRE	Kelch-like protein 26	Danio rerio (Zebrafish) (Brachydanio rerio)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]	GO:0031463; GO:0043161; GO:1990756
GN003457	GN003457.1	Q9WTK8	51.6	349	361	396	6.33e-128	375	SPO11_MOUSE	Meiotic recombination protein SPO11 (EC 5.6.2.2)	Mus musculus (Mouse)	double-strand break repair involved in meiotic recombination [GO:1990918]; homologous chromosome pairing at meiosis [GO:0007129]; male meiosis I [GO:0007141]; meiotic DNA double-strand break formation [GO:0042138]; meiotic DNA double-strand break processing [GO:0000706]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; ovarian follicle development [GO:0001541]; protein localization to chromosome [GO:0034502]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; synaptonemal complex assembly [GO:0007130]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]	GO:0000228; GO:0000706; GO:0000781; GO:0001541; GO:0003677; GO:0003918; GO:0004520; GO:0005524; GO:0005654; GO:0005694; GO:0007129; GO:0007130; GO:0007131; GO:0007141; GO:0007286; GO:0009330; GO:0034502; GO:0035861; GO:0042138; GO:0045141; GO:0048477; GO:1990918
GN003458	GN003458.1	O90760	29.4	170	552	341	7.35e-09	61.2	V031_FOWPN	Putative ankyrin repeat protein FPV031	Fowlpox virus (strain NVSL) (FPV)				
GN003460	GN003460.1	Q9U3V5	34.3	213	867	1024	5.78e-19	96.3	TIPT_DROME	Protein tiptop	Drosophila melanogaster (Fruit fly)	compound eye development [GO:0048749]; epidermis morphogenesis [GO:0048730]; Malpighian tubule stellate cell differentiation [GO:0061330]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of segmental identity, head [GO:0007380]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	nucleus [GO:0005634]	GO:0000122; GO:0000981; GO:0003677; GO:0005634; GO:0006357; GO:0007380; GO:0048730; GO:0048749; GO:0061330
GN003462	GN003462.1	Q5SVQ8	26.4	216	1320	909	8.95e-09	63.9	ZBT41_HUMAN	Zinc finger and BTB domain-containing protein 41	Homo sapiens (Human)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357
GN003463	GN003463.1	A5PLL7	66.7	246	278	270	2.36e-127	365	PEDS1_HUMAN	Plasmanylethanolamine desaturase 1 (EC 1.14.19.77) (Transmembrane protein 189)	Homo sapiens (Human)	ether lipid biosynthetic process [GO:0008611]; fatty acid metabolic process [GO:0006631]	plasmanylethanolamine desaturase activity [GO:0050207]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0006631; GO:0008611; GO:0050207
GN003464	GN003464.1	Q5RDW1	55.4	233	243	406	4.28e-85	261	MTG2_PONAB	Mitochondrial ribosome-associated GTPase 2 (GTP-binding protein 5)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	mitochondrial large ribosomal subunit assembly [GO:1902775]; regulation of mitochondrial translation [GO:0070129]; regulation of respiratory system process [GO:0044065]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial ribosome [GO:0005761]	GO:0000287; GO:0003924; GO:0005525; GO:0005743; GO:0005759; GO:0005761; GO:0044065; GO:0070129; GO:1902775
GN003468	GN003468.1	A7Y2W8	42.5	598	990	633	3.44e-153	470	SC6A9_XENLA	Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9)	Xenopus laevis (African clawed frog)	glycine import across plasma membrane [GO:1903804]; neurotransmitter transport [GO:0006836]; regulation of synaptic transmission, glycinergic [GO:0060092]; sodium ion transmembrane transport [GO:0035725]	amino acid:sodium symporter activity [GO:0005283]; glycine:sodium symporter activity [GO:0015375]	plasma membrane [GO:0005886]	GO:0005283; GO:0005886; GO:0006836; GO:0015375; GO:0035725; GO:0060092; GO:1903804
GN003469	GN003469.1	B3EWZ5	35.3	170	833	5145	7.02e-20	99.8	MLRP1_ACRMI	MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN003470	GN003470.1	Q99715	34.1	167	318	3063	3.39e-19	92.0	COCA1_HUMAN	Collagen alpha-1(XII) chain	Homo sapiens (Human)	collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen type XII trimer [GO:0005595]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]	GO:0005576; GO:0005595; GO:0005788; GO:0030020; GO:0030199; GO:0031012; GO:0035987; GO:0070062; GO:1903561
GN003472	GN003472.1	Q96S55	69.0	113	150	665	1.90e-51	176	WRIP1_HUMAN	ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1)	Homo sapiens (Human)	DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; single-stranded DNA helicase activity [GO:0017116]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0000731; GO:0003677; GO:0005524; GO:0005634; GO:0005737; GO:0006261; GO:0008047; GO:0016020; GO:0016887; GO:0017116; GO:0030174; GO:0042802; GO:0048471
GN003473	GN003473.1	Q91XU0	47.3	224	280	660	4.67e-50	177	WRIP1_MOUSE	ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1)	Mus musculus (Mouse)	DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; single-stranded DNA helicase activity [GO:0017116]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0000731; GO:0000781; GO:0003677; GO:0005524; GO:0005634; GO:0005737; GO:0006261; GO:0008047; GO:0016887; GO:0017116; GO:0030174; GO:0042802; GO:0048471
GN003474	GN003474.1	Q91XU0	61.5	52	232	660	2.52e-16	80.9	WRIP1_MOUSE	ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1)	Mus musculus (Mouse)	DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; single-stranded DNA helicase activity [GO:0017116]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0000731; GO:0000781; GO:0003677; GO:0005524; GO:0005634; GO:0005737; GO:0006261; GO:0008047; GO:0016887; GO:0017116; GO:0030174; GO:0042802; GO:0048471
GN003476	GN003476.1	A0A481NSZ4	27.9	394	385	473	1.17e-41	155	BPI_SEBSC	Bactericidal permeability-increasing protein (BPI) (Lipopolysaccharide-binding protein) (LBP)	Sebastes schlegelii (Korean rockfish)		lipid binding [GO:0008289]	extracellular region [GO:0005576]	GO:0005576; GO:0008289
GN003477	GN003477.1	A0A481NSZ4	24.6	142	143	473	3.00e-09	57.4	BPI_SEBSC	Bactericidal permeability-increasing protein (BPI) (Lipopolysaccharide-binding protein) (LBP)	Sebastes schlegelii (Korean rockfish)		lipid binding [GO:0008289]	extracellular region [GO:0005576]	GO:0005576; GO:0008289
GN003478	GN003478.1	Q99L04	49.1	330	327	313	1.22e-106	317	DHRS1_MOUSE	Dehydrogenase/reductase SDR family member 1 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 19C member 1) (Protein SDR19C1)	Mus musculus (Mouse)		carbonyl reductase (NADPH) activity [GO:0004090]; estradiol 17-alpha-dehydrogenase [NAD(P)+] activity [GO:0047881]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; testosterone dehydrogenase (NADP+) activity [GO:0047045]	endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0004090; GO:0005739; GO:0005743; GO:0005783; GO:0016616; GO:0047045; GO:0047881
GN003479	GN003479.1	Q8R2N2	36.5	694	672	686	8.53e-141	430	UTP4_MOUSE	U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (Testis-expressed gene 292 protein)	Mus musculus (Mouse)	maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of DNA-templated transcription [GO:0006355]; ribosomal small subunit biogenesis [GO:0042274]		90S preribosome [GO:0030686]; chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455]	GO:0000462; GO:0001650; GO:0005694; GO:0005730; GO:0006355; GO:0030490; GO:0030686; GO:0032040; GO:0034455; GO:0042274
GN003481	GN003481.1	P78417	41.3	143	207	241	9.79e-34	123	GSTO1_HUMAN	Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R)	Homo sapiens (Human)	cellular response to arsenic-containing substance [GO:0071243]; glutathione metabolic process [GO:0006749]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014810]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; xenobiotic catabolic process [GO:0042178]	glutathione dehydrogenase (ascorbate) activity [GO:0045174]; glutathione transferase activity [GO:0004364]; methylarsonate reductase activity [GO:0050610]; oxidoreductase activity [GO:0016491]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0004364; GO:0005737; GO:0005829; GO:0006749; GO:0010880; GO:0010881; GO:0014810; GO:0016491; GO:0019852; GO:0042178; GO:0045174; GO:0050610; GO:0051280; GO:0051281; GO:0070062; GO:0071243
GN003482	GN003482.1	P51893	81.1	433	433	433	4.25e-263	722	SAHHA_XENLA	Adenosylhomocysteinase A (AdoHcyase A) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase A)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003483	GN003483.1	P51893	86.5	229	232	433	6.44e-141	404	SAHHA_XENLA	Adenosylhomocysteinase A (AdoHcyase A) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase A)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003484	GN003484.1	P51893	73.4	177	183	433	8.65e-92	277	SAHHA_XENLA	Adenosylhomocysteinase A (AdoHcyase A) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase A)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003485	GN003485.1	O93477	86.4	88	108	433	1.42e-47	160	SAHHB_XENLA	Adenosylhomocysteinase B (AdoHcyase B) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase B)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003486	GN003486.1	P51893	86.5	229	232	433	6.44e-141	404	SAHHA_XENLA	Adenosylhomocysteinase A (AdoHcyase A) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase A)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003487	GN003487.1	P51893	74.6	177	183	433	2.68e-93	281	SAHHA_XENLA	Adenosylhomocysteinase A (AdoHcyase A) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase A)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003488	GN003488.1	O93477	86.4	88	108	433	5.12e-48	161	SAHHB_XENLA	Adenosylhomocysteinase B (AdoHcyase B) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase B)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003489	GN003489.1	P51893	86.7	248	275	433	2.20e-153	437	SAHHA_XENLA	Adenosylhomocysteinase A (AdoHcyase A) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase A)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003490	GN003490.1	P51893	74.6	177	183	433	2.68e-93	281	SAHHA_XENLA	Adenosylhomocysteinase A (AdoHcyase A) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase A)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003491	GN003491.1	O93477	86.4	88	108	433	5.12e-48	161	SAHHB_XENLA	Adenosylhomocysteinase B (AdoHcyase B) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase B)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003492	GN003492.1	P51893	77.6	143	143	433	6.49e-76	234	SAHHA_XENLA	Adenosylhomocysteinase A (AdoHcyase A) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase A)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003493	GN003493.1	O93477	88.6	88	108	433	1.21e-49	165	SAHHB_XENLA	Adenosylhomocysteinase B (AdoHcyase B) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase B)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003494	GN003494.1	O93477	90.7	107	139	433	7.51e-61	196	SAHHB_XENLA	Adenosylhomocysteinase B (AdoHcyase B) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase B)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003495	GN003495.1	O93477	89.4	47	50	433	2.70e-19	81.6	SAHHB_XENLA	Adenosylhomocysteinase B (AdoHcyase B) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase B)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003496	GN003496.1	P51893	73.4	177	183	433	8.65e-92	277	SAHHA_XENLA	Adenosylhomocysteinase A (AdoHcyase A) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase A)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003497	GN003497.1	O93477	87.5	88	108	433	1.31e-48	162	SAHHB_XENLA	Adenosylhomocysteinase B (AdoHcyase B) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase B)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003498	GN003498.1	P51893	72.6	223	223	433	7.71e-115	337	SAHHA_XENLA	Adenosylhomocysteinase A (AdoHcyase A) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase A)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN003500	GN003500.1	Q86WB7	24.0	287	410	457	1.05e-17	88.2	UN93A_HUMAN	N-acetylglucosamine transporter UNC93A (Protein unc-93 homolog A) (HmUnc-93A) (Unc-93A)	Homo sapiens (Human)		N-acetylglucosamine transmembrane transporter activity [GO:0015572]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0015572; GO:0016020
GN003501	GN003501.1	Q5REM2	45.7	81	100	99	9.93e-14	64.3	L10K_PONAB	Leydig cell tumor 10 kDa protein homolog	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)				
GN003504	GN003504.1	P58058	57.6	380	453	439	2.08e-153	445	NADK_MOUSE	NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase)	Mus musculus (Mouse)	NAD+ metabolic process [GO:0019674]; NADP+ biosynthetic process [GO:0006741]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	NAD+ kinase activity [GO:0003951]	cytosol [GO:0005829]	GO:0003951; GO:0005829; GO:0006741; GO:0019674; GO:0035774
GN003515	GN003515.1	Q6PGE7	42.0	517	548	637	2.28e-138	417	SC6A7_MOUSE	Sodium-dependent proline transporter (Solute carrier family 6 member 7)	Mus musculus (Mouse)	glycine import across plasma membrane [GO:1903804]; proline transmembrane transport [GO:0035524]; proline transport [GO:0015824]; protein catabolic process [GO:0030163]; sodium ion transmembrane transport [GO:0035725]	L-proline transmembrane transporter activity [GO:0015193]; proline:sodium symporter activity [GO:0005298]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; synaptic vesicle membrane [GO:0030672]	GO:0005298; GO:0005886; GO:0015193; GO:0015824; GO:0030163; GO:0030672; GO:0035524; GO:0035725; GO:0042734; GO:0045202; GO:0097060; GO:0098685; GO:0098978; GO:1903804
GN003516	GN003516.1	Q8C811	54.4	309	361	405	7.74e-108	324	S35E2_MOUSE	Solute carrier family 35 member E2A	Mus musculus (Mouse)	blastocyst hatching [GO:0001835]		membrane [GO:0016020]	GO:0001835; GO:0016020
GN003518	GN003518.1	Q3SYU1	49.3	209	322	746	1.47e-58	203	NOC2L_BOVIN	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor)	Bos taurus (Bovine)	ribosomal large subunit biogenesis [GO:0042273]		Noc1p-Noc2p complex [GO:0030690]; Noc2p-Noc3p complex [GO:0030691]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005730; GO:0030690; GO:0030691; GO:0042273
GN003520	GN003520.1	Q6MG64	28.0	654	1026	892	1.26e-36	153	VWA7_RAT	von Willebrand factor A domain-containing protein 7 (Protein G7c)	Rattus norvegicus (Rat)			extracellular region [GO:0005576]	GO:0005576
GN003521	GN003521.1	Q9ES00	50.0	1161	1321	1173	0.0	1055	UBE4B_MOUSE	Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)	Mus musculus (Mouse)	ERAD pathway [GO:0036503]; granzyme-mediated apoptotic signaling pathway [GO:0008626]; neuron projection development [GO:0031175]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein folding [GO:0006457]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to endoplasmic reticulum stress [GO:0034976]; response to UV [GO:0009411]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular trabecula myocardium morphogenesis [GO:0003222]	ATP binding [GO:0005524]; ATPase binding [GO:0051117]; enzyme binding [GO:0019899]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000209; GO:0003222; GO:0005524; GO:0005634; GO:0005737; GO:0006457; GO:0006511; GO:0006513; GO:0008626; GO:0009411; GO:0016567; GO:0019899; GO:0030163; GO:0031175; GO:0034450; GO:0034976; GO:0036503; GO:0043161; GO:0051117; GO:0051865; GO:0061630
GN003522	GN003522.1	O02654	84.2	203	210	434	1.18e-115	339	ENO_DORPE	Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)	Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)	glycolytic process [GO:0006096]	magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]	phosphopyruvate hydratase complex [GO:0000015]	GO:0000015; GO:0000287; GO:0004634; GO:0006096
GN003523	GN003523.1	P55205	33.7	193	711	1100	1.66e-25	116	GUC2G_RAT	Guanylate cyclase 2G (EC 4.6.1.2) (Guanylyl cyclase receptor G) (GC-G) (Kinase-like domain-containing soluble guanylyl cyclase) (ksGC)	Rattus norvegicus (Rat)	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005737; GO:0005886; GO:0006182; GO:0007168; GO:0035556
GN003524	GN003524.1	P52569	53.2	601	603	658	1.47e-211	607	CTR2_HUMAN	Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)	Homo sapiens (Human)	amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-lysine transmembrane transport [GO:1903401]; L-ornithine transmembrane transport [GO:1903352]; regulation of macrophage activation [GO:0043030]; transport across blood-brain barrier [GO:0150104]	amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]	cell junction [GO:0030054]; plasma membrane [GO:0005886]	GO:0000064; GO:0005886; GO:0006865; GO:0015171; GO:0015174; GO:0015179; GO:0015189; GO:0015807; GO:0030054; GO:0043030; GO:0061459; GO:0089718; GO:0097638; GO:0150104; GO:1902475; GO:1903352; GO:1903401; GO:1903826
GN003525	GN003525.1	P47236	65.0	123	859	203	6.14e-49	175	PAX1_CHICK	Paired box protein Pax-1	Gallus gallus (Chicken)	embryo development ending in birth or egg hatching [GO:0009792]; regulation of transcription by RNA polymerase II [GO:0006357]; sclerotome development [GO:0061056]; skeletal system development [GO:0001501]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001501; GO:0005634; GO:0006357; GO:0009792; GO:0061056
GN003529	GN003529.1	A1Z9X0	68.2	594	1526	606	2.15e-289	837	APKC_DROME	Atypical protein kinase C (EC 2.7.11.13)	Drosophila melanogaster (Fruit fly)	adherens junction organization [GO:0034332]; apical protein localization [GO:0045176]; asymmetric neuroblast division [GO:0055059]; asymmetric protein localization involved in cell fate determination [GO:0045167]; branching involved in open tracheal system development [GO:0060446]; cell-cell junction assembly [GO:0007043]; compound eye retinal cell programmed cell death [GO:0046667]; epithelial cell morphogenesis [GO:0003382]; establishment of cell polarity [GO:0030010]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of epithelial cell planar polarity [GO:0090163]; establishment of mitotic spindle orientation [GO:0000132]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of neuroblast polarity [GO:0045196]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; establishment or maintenance of polarity of follicular epithelium [GO:0016334]; exocyst localization [GO:0051601]; germarium-derived oocyte fate determination [GO:0007294]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; melanotic encapsulation of foreign target [GO:0035011]; memory [GO:0007613]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of hippo signaling [GO:0035331]; nuclear envelope budding [GO:0140591]; oocyte anterior/posterior axis specification [GO:0007314]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to plasma membrane [GO:0072659]; regulation of intracellular mRNA localization [GO:1904580]; regulation of polarized epithelial cell differentiation [GO:0030860]; sensory organ development [GO:0007423]; spermatogenesis [GO:0007283]; synapse assembly [GO:0007416]; terminal branching, open tracheal system [GO:0007430]; zonula adherens assembly [GO:0045186]	ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; myosin binding [GO:0017022]; PDZ domain binding [GO:0030165]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	apical cortex [GO:0045179]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cell cortex [GO:0005938]; PAR polarity complex [GO:0120157]; subapical complex [GO:0035003]	GO:0000132; GO:0001738; GO:0002052; GO:0003382; GO:0004674; GO:0004697; GO:0005524; GO:0005938; GO:0007043; GO:0007163; GO:0007283; GO:0007294; GO:0007314; GO:0007416; GO:0007423; GO:0007430; GO:0007613; GO:0010592; GO:0016324; GO:0016327; GO:0016332; GO:0016334; GO:0017022; GO:0030010; GO:0030011; GO:0030165; GO:0030860; GO:0034332; GO:0035003; GO:0035011; GO:0035331; GO:0035556; GO:0043296; GO:0045167; GO:0045176; GO:0045179; GO:0045186; GO:0045196; GO:0045197; GO:0045198; GO:0045880; GO:0046667; GO:0051491; GO:0051601; GO:0055059; GO:0060446; GO:0072659; GO:0090163; GO:0106310; GO:0120157; GO:0140591; GO:1904580
GN003530	GN003530.1	P47756	82.9	257	261	272	5.43e-157	440	CAPZB_HUMAN	F-actin-capping protein subunit beta (CapZ beta)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]	actin binding [GO:0003779]; cadherin binding [GO:0045296]	actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; sarcomere [GO:0030017]; Schaffer collateral - CA1 synapse [GO:0098685]; sperm head-tail coupling apparatus [GO:0120212]; WASH complex [GO:0071203]	GO:0003779; GO:0005829; GO:0005856; GO:0005903; GO:0008290; GO:0014069; GO:0015629; GO:0016020; GO:0030017; GO:0030027; GO:0030036; GO:0030863; GO:0045296; GO:0051016; GO:0070062; GO:0071203; GO:0098685; GO:0098686; GO:0120212
GN003535	GN003535.1	B1AJZ9	25.1	1469	1377	1412	3.59e-72	269	FHAD1_HUMAN	Forkhead-associated domain-containing protein 1 (FHA domain-containing protein 1)	Homo sapiens (Human)			sperm flagellum [GO:0036126]	GO:0036126
GN003537	GN003537.1	Q14DG7	25.0	979	1073	1078	8.17e-67	248	T132B_HUMAN	Transmembrane protein 132B	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN003538	GN003538.1	O75976	41.7	1281	1375	1380	1.72e-317	933	CBPD_HUMAN	Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)	Homo sapiens (Human)	peptide metabolic process [GO:0006518]; protein processing [GO:0016485]	metallocarboxypeptidase activity [GO:0004181]; serine-type carboxypeptidase activity [GO:0004185]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004181; GO:0004185; GO:0005886; GO:0006518; GO:0008270; GO:0016020; GO:0016485; GO:0070062
GN003539	GN003539.1	Q2VPU4	42.1	297	547	917	1.18e-56	207	MLXIP_MOUSE	MLX-interacting protein (Transcriptional activator MondoA)	Mus musculus (Mouse)	nucleocytoplasmic transport [GO:0006913]; positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000977; GO:0001228; GO:0003700; GO:0005634; GO:0005737; GO:0005741; GO:0006913; GO:0045944; GO:0046983; GO:0090575
GN003540	GN003540.1	Q8VIP2	64.6	198	362	865	1.34e-72	244	MLXPL_RAT	Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein)	Rattus norvegicus (Rat)	cellular response to glucose stimulus [GO:0071333]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; glucose mediated signaling pathway [GO:0010255]; lipid biosynthetic process [GO:0008610]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glycolytic process [GO:0045821]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of glycolytic process [GO:0006110]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]; response to nutrient [GO:0007584]; response to nutrient levels [GO:0031667]; response to vitamin B3 [GO:0033552]	carbohydrate response element binding [GO:0035538]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000432; GO:0000785; GO:0000978; GO:0000981; GO:0001216; GO:0001227; GO:0001228; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005829; GO:0006110; GO:0006357; GO:0007584; GO:0008284; GO:0008610; GO:0009749; GO:0010255; GO:0019901; GO:0031667; GO:0033552; GO:0035538; GO:0035774; GO:0042593; GO:0043565; GO:0045723; GO:0045821; GO:0045892; GO:0045893; GO:0045944; GO:0046889; GO:0046982; GO:0055089; GO:0061629; GO:0071333; GO:0090324; GO:0097009; GO:0140297; GO:1901797
GN003541	GN003541.1	P40926	63.5	277	280	338	2.90e-123	358	MDHM_HUMAN	Malate dehydrogenase, mitochondrial (EC 1.1.1.37)	Homo sapiens (Human)	aerobic respiration [GO:0009060]; gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]; malate-aspartate shuttle [GO:0043490]; tricarboxylic acid cycle [GO:0006099]	identical protein binding [GO:0042802]; L-malate dehydrogenase (NAD+) activity [GO:0030060]; L-malate dehydrogenase (NADP+) activity [GO:0046554]; RNA binding [GO:0003723]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005739; GO:0005759; GO:0006094; GO:0006099; GO:0006108; GO:0009060; GO:0016020; GO:0030060; GO:0042802; GO:0043490; GO:0046554; GO:0070062
GN003542	GN003542.1	Q6DRD9	43.5	207	220	317	4.08e-55	181	ABHDB_DANRE	sn-1-specific diacylglycerol lipase ABHD11 (EC 3.1.1.116) (Alpha/beta hydrolase domain-containing protein 11) (Abhydrolase domain-containing protein 11) (Williams-Beuren syndrome chromosomal region 21 protein homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	lipid metabolic process [GO:0006629]	carboxylic ester hydrolase activity [GO:0052689]; lipase activity [GO:0016298]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252]	GO:0005739; GO:0005759; GO:0006629; GO:0016298; GO:0045252; GO:0052689
GN003543	GN003543.1	Q0E908	30.9	793	841	818	5.90e-96	321	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN003544	GN003544.1	Q0E908	30.3	804	915	818	9.59e-91	309	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN003548	GN003548.1	Q9GP32	72.5	324	324	363	3.21e-166	469	ALF_ECHMU	Fructose-bisphosphate aldolase (EC 4.1.2.13)	Echinococcus multilocularis (Fox tapeworm)	glycolytic process [GO:0006096]	fructose-bisphosphate aldolase activity [GO:0004332]		GO:0004332; GO:0006096
GN003550	GN003550.1	A2BGR3	55.7	666	930	1451	8.47e-241	721	ERC6L_DANRE	DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like)	Danio rerio (Zebrafish) (Brachydanio rerio)	intein-mediated protein splicing [GO:0016539]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]	GO:0000775; GO:0003678; GO:0005524; GO:0005694; GO:0015616; GO:0016539; GO:0016887
GN003551	GN003551.1	Q9GP32	72.8	360	363	363	2.58e-187	525	ALF_ECHMU	Fructose-bisphosphate aldolase (EC 4.1.2.13)	Echinococcus multilocularis (Fox tapeworm)	glycolytic process [GO:0006096]	fructose-bisphosphate aldolase activity [GO:0004332]		GO:0004332; GO:0006096
GN003554	GN003554.1	Q2HJ57	42.9	133	140	142	2.54e-33	117	COTL1_BOVIN	Coactosin-like protein	Bos taurus (Bovine)	regulation of actin filament polymerization [GO:0030833]	actin filament binding [GO:0051015]	cortical actin cytoskeleton [GO:0030864]; nucleus [GO:0005634]; site of polarized growth [GO:0030427]	GO:0005634; GO:0030427; GO:0030833; GO:0030864; GO:0051015
GN003583	GN003583.1	Q0KHY3	30.3	824	820	1454	3.87e-79	282	MESH_DROME	Protein mesh	Drosophila melanogaster (Fruit fly)	cell-matrix adhesion [GO:0007160]; smooth septate junction assembly [GO:0090528]		apicolateral plasma membrane [GO:0016327]; plasma membrane [GO:0005886]; smooth septate junction [GO:0005920]	GO:0005886; GO:0005920; GO:0007160; GO:0016327; GO:0090528
GN003587	GN003587.1	Q0KHY3	29.1	897	1428	1454	2.17e-78	289	MESH_DROME	Protein mesh	Drosophila melanogaster (Fruit fly)	cell-matrix adhesion [GO:0007160]; smooth septate junction assembly [GO:0090528]		apicolateral plasma membrane [GO:0016327]; plasma membrane [GO:0005886]; smooth septate junction [GO:0005920]	GO:0005886; GO:0005920; GO:0007160; GO:0016327; GO:0090528
GN003601	GN003601.1	Q0KHY3	28.2	795	1285	1454	7.82e-59	226	MESH_DROME	Protein mesh	Drosophila melanogaster (Fruit fly)	cell-matrix adhesion [GO:0007160]; smooth septate junction assembly [GO:0090528]		apicolateral plasma membrane [GO:0016327]; plasma membrane [GO:0005886]; smooth septate junction [GO:0005920]	GO:0005886; GO:0005920; GO:0007160; GO:0016327; GO:0090528
GN003606	GN003606.1	Q0KHY3	29.1	897	1428	1454	8.96e-78	287	MESH_DROME	Protein mesh	Drosophila melanogaster (Fruit fly)	cell-matrix adhesion [GO:0007160]; smooth septate junction assembly [GO:0090528]		apicolateral plasma membrane [GO:0016327]; plasma membrane [GO:0005886]; smooth septate junction [GO:0005920]	GO:0005886; GO:0005920; GO:0007160; GO:0016327; GO:0090528
GN003629	GN003629.1	Q9JLY0	71.3	167	387	533	3.08e-76	248	SOCS6_MOUSE	Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; negative regulation of T cell activation [GO:0050868]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; regulation of growth [GO:0040008]	signaling adaptor activity [GO:0035591]	cytosol [GO:0005829]; immunological synapse [GO:0001772]	GO:0001772; GO:0005829; GO:0010498; GO:0016567; GO:0035556; GO:0035591; GO:0040008; GO:0050868
GN003630	GN003630.1	Q5PQN9	45.2	321	410	380	6.17e-86	269	RM38_RAT	Large ribosomal subunit protein mL38 (39S ribosomal protein L38, mitochondrial) (L38mt) (MRP-L38)	Rattus norvegicus (Rat)			mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0005762
GN003631	GN003631.1	P53568	59.0	83	124	150	3.00e-21	85.9	CEBPG_MOUSE	CCAAT/enhancer-binding protein gamma (C/EBP gamma) (Granulocyte colony-stimulating factor promoter element 1-binding protein) (GPE1-BP) (GPE1-binding protein) (Immunoglobulin enhancer-binding protein 1) (IG/EBP-1)	Mus musculus (Mouse)	B cell differentiation [GO:0030183]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; enucleate erythrocyte differentiation [GO:0043353]; immune response [GO:0006955]; liver development [GO:0001889]; mRNA metabolic process [GO:0016071]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome disassembly [GO:0006337]; positive regulation of DNA repair [GO:0045739]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending [GO:0044377]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000978; GO:0000981; GO:0001228; GO:0001889; GO:0003677; GO:0003690; GO:0003714; GO:0005634; GO:0005654; GO:0006337; GO:0006338; GO:0006351; GO:0006357; GO:0006955; GO:0016071; GO:0030183; GO:0032729; GO:0042267; GO:0043353; GO:0043565; GO:0044377; GO:0044877; GO:0045739; GO:0045944; GO:0090575; GO:0140297; GO:1990837
GN003632	GN003632.1	Q00322	49.5	99	315	268	2.53e-12	69.3	CEBPD_MOUSE	CCAAT/enhancer-binding protein delta (C/EBP delta) (C/EBP-related protein 3)	Mus musculus (Mouse)	DNA-templated transcription [GO:0006351]; fat cell differentiation [GO:0045444]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear development [GO:0048839]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000976; GO:0000978; GO:0000981; GO:0001228; GO:0002244; GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0006357; GO:0042802; GO:0043565; GO:0045444; GO:0045595; GO:0045669; GO:0045892; GO:0045944; GO:0048839; GO:0090575; GO:1990837
GN003635	GN003635.1	I6V1W0	27.5	305	308	612	8.59e-35	136	BMBL_DANRE	Protein brambleberry	Danio rerio (Zebrafish) (Brachydanio rerio)	karyomere membrane fusion [GO:0061472]; pronuclear fusion [GO:0007344]		nuclear membrane [GO:0031965]	GO:0007344; GO:0031965; GO:0061472
GN003638	GN003638.1	Q803K4	43.4	392	399	460	5.62e-86	271	SETD6_DANRE	N-lysine methyltransferase setd6 (EC 2.1.1.-) (SET domain-containing protein 6)	Danio rerio (Zebrafish) (Brachydanio rerio)	peptidyl-lysine monomethylation [GO:0018026]; regulation of inflammatory response [GO:0050727]	protein-lysine N-methyltransferase activity [GO:0016279]	nucleus [GO:0005634]	GO:0005634; GO:0016279; GO:0018026; GO:0050727
GN003646	GN003646.1	Q8QZR1	59.3	410	429	454	8.48e-180	512	ATTY_MOUSE	Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase)	Mus musculus (Mouse)	2-oxoglutarate metabolic process [GO:0006103]; amino acid metabolic process [GO:0006520]; cellular response to insulin stimulus [GO:0032869]; cellular response to retinoic acid [GO:0071300]; glutamate metabolic process [GO:0006536]; L-phenylalanine catabolic process [GO:0006559]; L-tyrosine catabolic process [GO:0006572]; liver regeneration [GO:0097421]; response to cAMP [GO:0051591]; response to cortisol [GO:0051414]; response to dexamethasone [GO:0071548]; response to ethanol [GO:0045471]; response to glucocorticoid [GO:0051384]; response to mercury ion [GO:0046689]; response to oxidative stress [GO:0006979]	amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; L-tyrosine:2-oxoglutarate transaminase activity [GO:0004838]; pyridoxal phosphate binding [GO:0030170]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0004838; GO:0005739; GO:0005829; GO:0006103; GO:0006520; GO:0006536; GO:0006559; GO:0006572; GO:0006979; GO:0016597; GO:0030170; GO:0032869; GO:0042802; GO:0045471; GO:0046689; GO:0051384; GO:0051414; GO:0051591; GO:0071300; GO:0071548; GO:0097421
GN003648	GN003648.1	Q8SWR3	31.3	329	429	435	2.98e-28	119	SPR_DROME	Sex peptide receptor	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of egg-laying behavior [GO:0046662]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008528; GO:0045434; GO:0046662
GN003653	GN003653.1	P08953	22.0	576	796	1097	7.79e-13	76.3	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN003654	GN003654.1	O88845	31.0	261	326	662	1.04e-20	96.3	AKA10_MOUSE	A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10)	Mus musculus (Mouse)	intracellular protein localization [GO:0008104]	protein kinase A binding [GO:0051018]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GO:0005739; GO:0005829; GO:0005886; GO:0008104; GO:0032991; GO:0051018
GN003666	GN003666.1	H2A0N4	31.4	118	312	1014	4.27e-09	61.2	PIF_PINMG	Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)]	Margaritifera margaritifera (Freshwater pearl mussel)		chitin binding [GO:0008061]	extracellular region [GO:0005576]	GO:0005576; GO:0008061
GN003668	GN003668.1	P43024	36.3	124	135	111	5.14e-14	66.6	CX6A1_MOUSE	Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver)	Mus musculus (Mouse)	mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	enzyme regulator activity [GO:0030234]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; respiratory chain complex IV [GO:0045277]; sperm principal piece [GO:0097228]	GO:0005739; GO:0005743; GO:0006123; GO:0030234; GO:0031966; GO:0043209; GO:0045277; GO:0097228
GN003671	GN003671.1	A0A8B8EY61	30.6	575	598	632	8.79e-77	259	CGLR2_CRAVI	Cyclic GMP-AMP synthase-like receptor 2 (Cv-cGLR2) (EC 2.7.7.-)	Crassostrea virginica (Eastern oyster)				
GN003672	GN003672.1	Q30TG0	44.6	213	220	266	1.78e-53	175	ISPE_SULDN	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (EC 2.7.1.148) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase)	Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; terpenoid biosynthetic process [GO:0016114]	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity [GO:0050515]; ATP binding [GO:0005524]		GO:0005524; GO:0016114; GO:0019288; GO:0050515
GN003673	GN003673.1	Q96LW2	42.7	293	396	410	9.99e-76	243	KS6R_HUMAN	Ribosomal protein S6 kinase-related protein (EC 2.7.11.1) (Sugen kinase 494)	Homo sapiens (Human)		ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]		GO:0004672; GO:0004674; GO:0005524; GO:0106310
GN003683	GN003683.1	Q7YRA3	61.2	165	168	245	2.84e-67	207	EXOS4_BOVIN	Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41)	Bos taurus (Bovine)	DNA deamination [GO:0045006]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; nuclear mRNA surveillance [GO:0071028]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; rRNA catabolic process [GO:0016075]; U4 snRNA 3'-end processing [GO:0034475]	mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0000176; GO:0000177; GO:0000178; GO:0000460; GO:0000791; GO:0003723; GO:0005654; GO:0005730; GO:0005829; GO:0016075; GO:0030307; GO:0034475; GO:0035925; GO:0045006; GO:0071028; GO:0071044; GO:0071051
GN003684	GN003684.1	O35643	73.8	953	932	943	0.0	1333	AP1B1_MOUSE	AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)	Mus musculus (Mouse)	basolateral protein secretion [GO:0110010]; clathrin coat assembly [GO:0048268]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; receptor-mediated endocytosis [GO:0006898]; vesicle-mediated transport [GO:0016192]	clathrin binding [GO:0030276]; protein kinase binding [GO:0019901]; protein serine/threonine kinase binding [GO:0120283]	AP-1 adaptor complex [GO:0030121]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	GO:0001822; GO:0005765; GO:0005769; GO:0005794; GO:0005802; GO:0005829; GO:0006886; GO:0006898; GO:0007368; GO:0007507; GO:0008021; GO:0016192; GO:0019901; GO:0030121; GO:0030276; GO:0032588; GO:0048268; GO:0060155; GO:0110010; GO:0120283; GO:1903232
GN003687	GN003687.1	Q3ZBL5	54.5	165	173	179	6.83e-55	174	PTH2_BOVIN	Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription)	Bos taurus (Bovine)	negative regulation of anoikis [GO:2000811]; positive regulation of anoikis [GO:2000210]	peptidyl-tRNA hydrolase activity [GO:0004045]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]	GO:0004045; GO:0005741; GO:0005829; GO:2000210; GO:2000811
GN003688	GN003688.1	Q9CXE7	26.4	193	217	229	1.39e-18	84.0	TMED5_MOUSE	Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2)	Mus musculus (Mouse)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi ribbon formation [GO:0090161]		cis-Golgi network [GO:0005801]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]	GO:0005789; GO:0005793; GO:0005801; GO:0006888; GO:0033116; GO:0070971; GO:0090161
GN003689	GN003689.1	Q803E1	44.6	74	786	694	1.48e-13	78.2	NCBP3_DANRE	Nuclear cap-binding protein subunit 3	Danio rerio (Zebrafish) (Brachydanio rerio)		mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA cap binding [GO:0000339]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000339; GO:0000340; GO:0003729; GO:0005634; GO:0005737
GN003690	GN003690.1	Q9D787	58.6	485	499	521	1.30e-191	547	PPIL2_MOUSE	RING-type E3 ubiquitin-protein ligase PPIL2 (EC 2.3.2.27) (CYC4) (Probable inactive peptidyl-prolyl cis-trans isomerase-like 2) (PPIase)	Mus musculus (Mouse)	protein folding [GO:0006457]; protein localization to plasma membrane [GO:0072659]; protein polyubiquitination [GO:0000209]	peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spliceosomal complex [GO:0005681]; U12-type catalytic step 2 spliceosome [GO:0071018]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0000209; GO:0003755; GO:0004842; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0005886; GO:0006457; GO:0034450; GO:0061630; GO:0071006; GO:0071013; GO:0071018; GO:0072659
GN003691	GN003691.1	Q4KLN4	44.6	130	128	698	3.24e-32	122	GLE1_RAT	mRNA export factor GLE1 (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1)	Rattus norvegicus (Rat)	poly(A)+ mRNA export from nucleus [GO:0016973]	identical protein binding [GO:0042802]; inositol hexakisphosphate binding [GO:0000822]; phospholipid binding [GO:0005543]; translation initiation factor binding [GO:0031369]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore cytoplasmic filaments [GO:0044614]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0000822; GO:0005543; GO:0005634; GO:0005635; GO:0005730; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0016973; GO:0031369; GO:0031965; GO:0036064; GO:0042802; GO:0044614
GN003697	GN003697.1	Q9H5L6	33.1	136	133	903	3.53e-14	71.2	THAP9_HUMAN	DNA transposase THAP9 (EC 2.7.7.-) (THAP domain-containing protein 9) (hTh9)	Homo sapiens (Human)	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA transposition [GO:0006313]	DNA binding [GO:0003677]; sequence-specific DNA binding [GO:0043565]; transposase activity [GO:0004803]		GO:0003677; GO:0004803; GO:0006310; GO:0006313; GO:0015074; GO:0043565
GN003704	GN003704.1	Q98943	24.1	316	424	424	2.29e-21	99.0	CASP2_CHICK	Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]	Gallus gallus (Chicken)	apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]	cysteine-type endopeptidase activity [GO:0004197]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]; endopeptidase complex [GO:1905369]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0004197; GO:0005634; GO:0005737; GO:0005739; GO:0006915; GO:0008630; GO:0016485; GO:0019904; GO:0030330; GO:0042802; GO:0043525; GO:0071260; GO:0097192; GO:1905369
GN003705	GN003705.1	A1L0Y2	48.5	1508	1444	1477	0.0	1355	NEUL4_XENTR	Neuralized-like protein 4	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mitochondrial DNA repair [GO:0043504]	ubiquitin protein ligase activity [GO:0061630]	centriole [GO:0005814]; mitochondrion [GO:0005739]	GO:0005739; GO:0005814; GO:0043504; GO:0061630
GN003706	GN003706.1	Q8WYH8	56.2	251	244	240	9.23e-90	268	ING5_HUMAN	Inhibitor of growth protein 5 (p28ING5)	Homo sapiens (Human)	DNA replication-dependent chromatin disassembly [GO:0140889]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of growth [GO:0045926]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein acetylation [GO:0006473]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of developmental process [GO:0050793]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]	chromatin binding [GO:0003682]; histone H3K4me3 reader activity [GO:0140002]	chromosome [GO:0005694]; histone acetyltransferase complex [GO:0000123]; MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000123; GO:0001558; GO:0003682; GO:0005634; GO:0005654; GO:0005694; GO:0006275; GO:0006355; GO:0006473; GO:0008285; GO:0043065; GO:0045926; GO:0050793; GO:0051726; GO:0070776; GO:0140002; GO:0140889; GO:1903706; GO:2000278; GO:2001235
GN003707	GN003707.1	Q9M146	24.7	271	348	360	1.83e-14	77.0	MGP4_ARATH	UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase MGP4 (EC 2.4.2.-) (Protein MALE GAMETOPHYTE DEFECTIVE 4) (Rhamnogalacturonan xylosyltransferase MGP4)	Arabidopsis thaliana (Mouse-ear cress)	pollen tube development [GO:0048868]; rhamnogalacturonan II biosynthetic process [GO:0010306]	xylosyltransferase activity [GO:0042285]	chloroplast [GO:0009507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]	GO:0000138; GO:0000139; GO:0005794; GO:0009507; GO:0010306; GO:0042285; GO:0048868
GN003708	GN003708.1	Q5EAJ7	72.5	854	856	857	0.0	1129	MVP_STRPU	Major vault protein (MVP)	Strongylocentrotus purpuratus (Purple sea urchin)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN003713	GN003713.1	Q9D0F6	70.4	162	163	339	8.95e-78	237	RFC5_MOUSE	Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)	Mus musculus (Mouse)	DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; enzyme binding [GO:0019899]; single-stranded DNA helicase activity [GO:0017116]	Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleus [GO:0005634]; Rad17 RFC-like complex [GO:0031389]	GO:0003677; GO:0003689; GO:0005524; GO:0005634; GO:0005663; GO:0006261; GO:0006281; GO:0016887; GO:0017116; GO:0019899; GO:0031389; GO:0031390; GO:1900264
GN003714	GN003714.1	Q61097	38.6	567	738	873	1.52e-110	358	KSR1_MOUSE	Kinase suppressor of Ras 1 (mKSR1) (EC 2.7.11.1) (Protein Hb)	Mus musculus (Mouse)	positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265]; regulation of cell population proliferation [GO:0042127]; regulation of MAP kinase activity [GO:0043405]	14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; Hsp90 protein binding [GO:0051879]; MAP kinase scaffold activity [GO:0005078]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]	GO:0004672; GO:0004674; GO:0005078; GO:0005524; GO:0005737; GO:0005783; GO:0005789; GO:0005829; GO:0005886; GO:0007265; GO:0016020; GO:0019901; GO:0031434; GO:0032587; GO:0032991; GO:0042127; GO:0043405; GO:0043410; GO:0051087; GO:0051879; GO:0071889; GO:0106310
GN003716	GN003716.1	P29030	49.0	49	356	504	3.66e-10	64.7	CHIT_BRUMA	Endochitinase (EC 3.2.1.14) (MF1 antigen)	Brugia malayi (Filarial nematode worm)	carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]	chitin binding [GO:0008061]; endochitinase activity [GO:0008843]	extracellular region [GO:0005576]	GO:0005576; GO:0005975; GO:0006032; GO:0008061; GO:0008843
GN003717	GN003717.1	Q7ZXK9	65.8	395	484	476	4.26e-165	478	NLE1_XENLA	Notchless protein homolog 1	Xenopus laevis (African clawed frog)	Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; ribosomal large subunit assembly [GO:0000027]		nucleolus [GO:0005730]	GO:0000027; GO:0005730; GO:0007219; GO:0008593
GN003718	GN003718.1	Q9CQL5	38.8	121	173	180	9.59e-22	89.7	RM18_MOUSE	Large ribosomal subunit protein uL18m (39S ribosomal protein L18, mitochondrial) (L18mt) (MRP-L18)	Mus musculus (Mouse)	mitochondrial translation [GO:0032543]; rRNA import into mitochondrion [GO:0035928]	5S rRNA binding [GO:0008097]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005762; GO:0008097; GO:0032543; GO:0035928
GN003719	GN003719.1	Q5F4A9	65.5	84	264	231	1.13e-27	109	AR6P4_CHICK	ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL-6-interacting protein 4) (Aip-4)	Gallus gallus (Chicken)			nuclear speck [GO:0016607]; nucleolus [GO:0005730]	GO:0005730; GO:0016607
GN003720	GN003720.1	Q99583	46.9	147	603	582	1.49e-22	105	MNT_HUMAN	Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; Mad-Max complex [GO:0070443]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571]	GO:0000122; GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0006357; GO:0006366; GO:0042802; GO:0046983; GO:0070443; GO:0090571
GN003723	GN003723.1	Q9Y6X9	62.6	484	530	1032	6.84e-201	590	MORC2_HUMAN	ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; constitutive heterochromatin formation [GO:0140719]; DNA damage response [GO:0006974]; transposable element silencing by heterochromatin formation [GO:0141005]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000792; GO:0003682; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005829; GO:0006338; GO:0006974; GO:0008270; GO:0016363; GO:0016887; GO:0042802; GO:0042803; GO:0140658; GO:0140719; GO:0141005
GN003725	GN003725.1	Q9Y6X9	31.7	142	178	1032	6.48e-11	63.5	MORC2_HUMAN	ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; constitutive heterochromatin formation [GO:0140719]; DNA damage response [GO:0006974]; transposable element silencing by heterochromatin formation [GO:0141005]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000792; GO:0003682; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005829; GO:0006338; GO:0006974; GO:0008270; GO:0016363; GO:0016887; GO:0042802; GO:0042803; GO:0140658; GO:0140719; GO:0141005
GN003726	GN003726.1	P79779	63.0	200	523	361	2.39e-89	281	TBX6L_CHICK	T-box-containing protein TBX6L	Gallus gallus (Chicken)	anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001708; GO:0005634; GO:0006357; GO:0009653; GO:0045893
GN003727	GN003727.1	B0S6U7	33.2	398	452	447	9.65e-56	194	ERAL1_DANRE	GTPase Era, mitochondrial (ERA-like protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	ribosomal small subunit assembly [GO:0000028]	GTP binding [GO:0005525]; ribosomal small subunit binding [GO:0043024]; rRNA binding [GO:0019843]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]	GO:0000028; GO:0005525; GO:0005743; GO:0005759; GO:0019843; GO:0043024
GN003728	GN003728.1	Q86P97	71.9	359	348	422	2.45e-174	493	SPPL_DROME	Signal peptide peptidase-like (EC 3.4.23.-) (Intramembrane protease SppL)	Drosophila melanogaster (Fruit fly)	membrane protein proteolysis [GO:0033619]; protein processing [GO:0016485]	aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; signal peptidase activity [GO:0009003]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]	GO:0000139; GO:0005783; GO:0005794; GO:0009003; GO:0016020; GO:0016485; GO:0030660; GO:0033619; GO:0042500; GO:0098553; GO:0098554
GN003729	GN003729.1	Q9H7L9	69.5	128	208	328	5.71e-44	152	SDS3_HUMAN	Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; substantia nigra development [GO:0021762]	enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822]	GO:0000122; GO:0005634; GO:0005654; GO:0006338; GO:0016604; GO:0019899; GO:0021762; GO:0030336; GO:0030512; GO:0042802; GO:0042826; GO:0045892; GO:0070822; GO:1902455; GO:1902459
GN003730	GN003730.1	Q3MHP1	77.3	154	155	154	2.67e-84	247	UB2L3_BOVIN	Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (Ubiquitin carrier protein L3) (Ubiquitin-protein ligase L3)	Bos taurus (Bovine)	cell cycle phase transition [GO:0044770]; cell population proliferation [GO:0008283]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to steroid hormone stimulus [GO:0071383]; protein K11-linked ubiquitination [GO:0070979]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA-templated transcription [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511]	transcription coactivator activity [GO:0003713]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000209; GO:0003713; GO:0004842; GO:0005634; GO:0005737; GO:0006355; GO:0006511; GO:0008283; GO:0016567; GO:0044770; GO:0061631; GO:0070979; GO:0071383; GO:0071385
GN003731	GN003731.1	Q8K2J9	31.9	395	456	539	5.17e-47	173	BTBD6_MOUSE	BTB/POZ domain-containing protein 6	Mus musculus (Mouse)	neurogenesis [GO:0022008]		cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0022008
GN003732	GN003732.1	Q56R14	27.3	293	765	1091	6.81e-20	99.0	TRI33_XENLA	E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)	Xenopus laevis (African clawed frog)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0008270; GO:0016567; GO:0061630
GN003734	GN003734.1	Q5F3P8	57.8	327	1561	2008	2.77e-97	351	SET1B_CHICK	Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.354) (SET domain-containing protein 1B)	Gallus gallus (Chicken)		histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 trimethyltransferase activity [GO:0140999]; RNA binding [GO:0003723]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005694; GO:0005737; GO:0016607; GO:0042800; GO:0048188; GO:0140999
GN003735	GN003735.1	F8VPZ3	46.7	1676	1545	1604	0.0	1435	UBP32_MOUSE	Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32)	Mus musculus (Mouse)	positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]	calcium ion binding [GO:0005509]; cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; recycling endosome [GO:0055037]	GO:0000139; GO:0004843; GO:0005509; GO:0005737; GO:0005794; GO:0005829; GO:0005886; GO:0016579; GO:0055037; GO:0098978; GO:0099092; GO:1904263
GN003736	GN003736.1	Q3T0M7	76.1	134	231	206	9.91e-66	205	RANG_BOVIN	Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)	Bos taurus (Bovine)	nuclear export [GO:0051168]		cytoplasm [GO:0005737]; nuclear pore [GO:0005643]	GO:0005643; GO:0005737; GO:0051168
GN003737	GN003737.1	Q5BLE8	41.6	580	600	607	3.70e-172	505	RETST_DANRE	All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase A) (RetSat A) (All-trans-retinol 7,8-reductase)	Danio rerio (Zebrafish) (Brachydanio rerio)	retinol metabolic process [GO:0042572]	all-trans-retinol 13,14-reductase activity [GO:0051786]	endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0042572; GO:0051786
GN003738	GN003738.1	Q5BLE8	41.6	584	627	607	4.47e-164	485	RETST_DANRE	All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase A) (RetSat A) (All-trans-retinol 7,8-reductase)	Danio rerio (Zebrafish) (Brachydanio rerio)	retinol metabolic process [GO:0042572]	all-trans-retinol 13,14-reductase activity [GO:0051786]	endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0042572; GO:0051786
GN003739	GN003739.1	Q8N3Y1	30.8	522	653	598	3.20e-62	220	FBXW8_HUMAN	F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)	Homo sapiens (Human)	cell population proliferation [GO:0008283]; cilium assembly [GO:0060271]; Golgi organization [GO:0007030]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005737; GO:0005794; GO:0005814; GO:0005829; GO:0006511; GO:0007030; GO:0008283; GO:0016567; GO:0019005; GO:0031146; GO:0031467; GO:0032436; GO:0036064; GO:0043161; GO:0046627; GO:0048471; GO:0050775; GO:0060271; GO:1990756
GN003742	GN003742.1	A5WWA0	41.7	242	830	868	7.51e-49	189	ZNRF3_DANRE	E3 ubiquitin-protein ligase znrf3 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase znrf3) (Zinc/RING finger protein 3)	Danio rerio (Zebrafish) (Brachydanio rerio)	negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein ubiquitination [GO:0016567]; stem cell proliferation [GO:0072089]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt receptor catabolic process [GO:0038018]	frizzled binding [GO:0005109]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	plasma membrane [GO:0005886]	GO:0004842; GO:0005109; GO:0005886; GO:0006511; GO:0016567; GO:0038018; GO:0061630; GO:0072089; GO:0090090; GO:2000051
GN003743	GN003743.1	Q04336	34.5	941	855	1088	4.59e-148	467	YM54_YEAST	Uncharacterized protein YMR196W	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	oligosaccharide metabolic process [GO:0009311]	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [GO:0004573]	cytoplasm [GO:0005737]	GO:0004573; GO:0005737; GO:0009311
GN003746	GN003746.1	D3ZVM4	46.6	582	786	855	4.32e-163	497	LIN41_RAT	E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)	Rattus norvegicus (Rat)	3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA processing [GO:0035196]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; post-transcriptional regulation of gene expression [GO:0010608]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of miRNA-mediated gene silencing [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of protein metabolic process [GO:0051246]; stem cell proliferation [GO:0072089]	miRNA binding [GO:0035198]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	P-body [GO:0000932]	GO:0000082; GO:0000209; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010608; GO:0017148; GO:0021915; GO:0030371; GO:0035196; GO:0035198; GO:0035278; GO:0043161; GO:0051246; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637
GN003747	GN003747.1	A4IFB6	41.3	704	695	743	7.24e-165	494	CNO10_BOVIN	CCR4-NOT transcription complex subunit 10	Bos taurus (Bovine)	mRNA catabolic process [GO:0006402]; negative regulation of translation [GO:0017148]		CCR4-NOT complex [GO:0030014]; cytosol [GO:0005829]	GO:0005829; GO:0006402; GO:0017148; GO:0030014
GN003749	GN003749.1	Q8N4L2	49.3	211	237	257	8.59e-65	204	PP4P2_HUMAN	Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)	Homo sapiens (Human)	negative regulation of phagocytosis [GO:0050765]; phosphatidylinositol dephosphorylation [GO:0046856]	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity [GO:0034597]	late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	GO:0005765; GO:0005886; GO:0030670; GO:0031902; GO:0034597; GO:0046856; GO:0050765
GN003751	GN003751.1	Q2NL00	30.9	204	217	240	2.36e-15	75.5	GSTT1_BOVIN	Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1)	Bos taurus (Bovine)	glutathione metabolic process [GO:0006749]	glutathione transferase activity [GO:0004364]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004364; GO:0005737; GO:0005829; GO:0006749
GN003752	GN003752.1	Q9Y2L5	41.2	1525	1476	1435	0.0	1018	TPPC8_HUMAN	Trafficking protein particle complex subunit 8 (Protein TRS85 homolog)	Homo sapiens (Human)	collagen biosynthetic process [GO:0032964]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; vesicle tethering [GO:0099022]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072]	GO:0005737; GO:0005829; GO:0006888; GO:0007030; GO:0030008; GO:0032964; GO:0048208; GO:0099022; GO:1990072
GN003753	GN003753.1	Q14703	63.6	1059	1063	1052	0.0	1372	MBTP1_HUMAN	Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Subtilisin/kexin-isozyme 1) (SKI-1)	Homo sapiens (Human)	ATF6-mediated unfolded protein response [GO:0036500]; endoplasmic reticulum unfolded protein response [GO:0030968]; lysosome organization [GO:0007040]; membrane protein intracellular domain proteolysis [GO:0031293]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of vesicle-mediated transport [GO:0060627]; response to endoplasmic reticulum stress [GO:0034976]	serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; mitochondrion [GO:0005739]	GO:0000139; GO:0004252; GO:0005576; GO:0005739; GO:0005788; GO:0005789; GO:0005795; GO:0006508; GO:0007040; GO:0007095; GO:0016485; GO:0030968; GO:0031293; GO:0034976; GO:0036500; GO:0045540; GO:0051604; GO:0060627
GN003755	GN003755.1	Q19673	32.7	300	468	693	1.55e-44	169	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN003756	GN003756.1	Q99P25	33.5	711	713	704	2.79e-120	379	TXIP1_MOUSE	Translin-associated factor X-interacting protein 1 (Trax-interacting protein 1)	Mus musculus (Mouse)			cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]	GO:0005737; GO:0048471
GN003757	GN003757.1	A1L252	60.7	516	505	597	2.19e-205	585	RANB9_DANRE	Ran-binding protein 9 (RanBP9)	Danio rerio (Zebrafish) (Brachydanio rerio)	cytoskeleton organization [GO:0007010]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; retina development in camera-type eye [GO:0060041]	protein-macromolecule adaptor activity [GO:0030674]	cytoplasm [GO:0005737]; GID complex [GO:0034657]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005737; GO:0005886; GO:0007010; GO:0030674; GO:0034657; GO:0043161; GO:0060041
GN003758	GN003758.1	O95707	38.2	89	101	220	4.06e-10	57.4	RPP29_HUMAN	Ribonuclease P protein subunit p29 (hPOP4)	Homo sapiens (Human)	RNA processing [GO:0006396]; tRNA 5'-leader removal [GO:0001682]	ribonuclease P RNA binding [GO:0033204]	multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]; ribonuclease P complex [GO:0030677]	GO:0000172; GO:0001682; GO:0005634; GO:0005654; GO:0005655; GO:0005730; GO:0006396; GO:0030677; GO:0030681; GO:0033204
GN003759	GN003759.1	A2AV36	42.2	685	686	683	1.58e-194	568	ANM7_DANRE	Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7)	Danio rerio (Zebrafish) (Brachydanio rerio)	cytoskeleton organization [GO:0007010]; genomic imprinting [GO:0071514]; spliceosomal snRNP assembly [GO:0000387]	histone H4R3 methyltransferase activity [GO:0044020]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; protein-arginine omega-N symmetric methyltransferase activity [GO:0035243]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000387; GO:0005634; GO:0005829; GO:0007010; GO:0008757; GO:0035241; GO:0035243; GO:0044020; GO:0071514
GN003760	GN003760.1	Q9Y5Y6	33.5	170	303	855	7.70e-13	72.4	ST14_HUMAN	Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein)	Homo sapiens (Human)	keratinocyte differentiation [GO:0030216]; protein processing [GO:0016485]; proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0004252; GO:0005576; GO:0005886; GO:0006508; GO:0008236; GO:0009897; GO:0016485; GO:0030216
GN003762	GN003762.1	Q6AYR2	45.2	341	365	375	8.79e-84	262	NDRG3_RAT	Protein NDRG3 (N-myc downstream-regulated gene 3 protein)	Rattus norvegicus (Rat)	decidualization [GO:0046697]; signal transduction [GO:0007165]		cytoplasm [GO:0005737]	GO:0005737; GO:0007165; GO:0046697
GN003763	GN003763.1	Q7ZWB7	77.4	341	340	342	1.46e-196	546	BBS5_DANRE	BBSome complex member BBS5 (Bardet-Biedl syndrome 5 protein homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	camera-type eye development [GO:0043010]; camera-type eye photoreceptor cell development [GO:0062139]; cilium assembly [GO:0060271]; gastrulation [GO:0007369]; heart looping [GO:0001947]; Kupffer's vesicle development [GO:0070121]; melanosome transport [GO:0032402]; pigment granule aggregation in cell center [GO:0051877]; pronephros formation [GO:0072116]	phosphatidylinositol-3-phosphate binding [GO:0032266]	BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]	GO:0001947; GO:0007369; GO:0032266; GO:0032402; GO:0034451; GO:0034464; GO:0036064; GO:0043010; GO:0051877; GO:0060170; GO:0060271; GO:0062139; GO:0070121; GO:0072116
GN003764	GN003764.1	Q96S44	55.6	153	152	253	2.87e-46	154	PRPK_HUMAN	EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase)	Homo sapiens (Human)	maintenance of translational fidelity [GO:1990145]; protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; tRNA threonylcarbamoyladenosine metabolic process [GO:0070525]	ATP binding [GO:0005524]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000408; GO:0002039; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006468; GO:0070525; GO:0106310; GO:1901796; GO:1990145
GN003765	GN003765.1	A6QQZ0	30.3	320	322	358	1.84e-34	132	GDAP1_BOVIN	Ganglioside-induced differentiation-associated protein 1 (GDAP1)	Bos taurus (Bovine)	mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]		cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]	GO:0000266; GO:0005737; GO:0005741; GO:0008053
GN003766	GN003766.1	Q91766	74.4	340	473	464	1.43e-177	508	HNF4A_XENLA	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1)	Xenopus laevis (African clawed frog)	cell differentiation [GO:0030154]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]	nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0000978; GO:0003707; GO:0004879; GO:0005634; GO:0008270; GO:0030154; GO:0042752; GO:0045893; GO:0045944
GN003767	GN003767.1	P00507	69.0	393	393	430	1.56e-205	575	AATM_RAT	Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)	Rattus norvegicus (Rat)	2-oxoglutarate metabolic process [GO:0006103]; amino acid metabolic process [GO:0006520]; aspartate metabolic process [GO:0006531]; dicarboxylic acid metabolic process [GO:0043648]; fatty acid transport [GO:0015908]; female pregnancy [GO:0007565]; glutamate metabolic process [GO:0006536]; L-asparagine biosynthetic process [GO:0070981]; L-aspartate biosynthetic process [GO:0006532]; L-aspartate catabolic process [GO:0006533]; L-glutamate biosynthetic process [GO:0097054]; L-glutamate catabolic process [GO:0006538]; L-glutamine catabolic process [GO:0006543]; lactation [GO:0007595]; malate-aspartate shuttle [GO:0043490]; oxaloacetate metabolic process [GO:0006107]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to muscle activity [GO:0014850]	amino acid binding [GO:0016597]; carboxylic acid binding [GO:0031406]; enzyme binding [GO:0019899]; L-aspartate:2-oxoglutarate transaminase activity [GO:0004069]; L-kynurenine:2-oxoglutarate transaminase activity [GO:0016212]; phospholipid binding [GO:0005543]; pyridoxal phosphate binding [GO:0030170]	cell surface [GO:0009986]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]	GO:0004069; GO:0005543; GO:0005739; GO:0005743; GO:0005759; GO:0005886; GO:0006103; GO:0006107; GO:0006520; GO:0006531; GO:0006532; GO:0006533; GO:0006536; GO:0006538; GO:0006543; GO:0007565; GO:0007595; GO:0009986; GO:0014850; GO:0015908; GO:0016212; GO:0016597; GO:0019899; GO:0030170; GO:0030315; GO:0031406; GO:0032868; GO:0032991; GO:0042383; GO:0043204; GO:0043490; GO:0043648; GO:0045471; GO:0070981; GO:0097054
GN003774	GN003774.1	Q99KW9	35.7	549	662	610	4.16e-88	290	TIP_MOUSE	T-cell immunomodulatory protein (Protein TIP) (Integrin-alpha FG-GAP repeat-containing protein 1) (Linkin)	Mus musculus (Mouse)			extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005576; GO:0005886
GN003775	GN003775.1	Q3ZBX6	40.6	271	394	348	1.17e-54	187	RM03_BOVIN	Large ribosomal subunit protein uL3m (39S ribosomal protein L3, mitochondrial) (L3mt) (MRP-L3)	Bos taurus (Bovine)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005762; GO:0006412
GN003776	GN003776.1	Q2HJG5	72.2	731	730	796	0.0	1071	VPS35_BOVIN	Vacuolar protein sorting-associated protein 35 (Vesicle protein sorting 35)	Bos taurus (Bovine)	endocytic recycling [GO:0032456]; endosome to plasma membrane protein transport [GO:0099638]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrion to lysosome vesicle-mediated transport [GO:0099074]; negative regulation of inflammatory response [GO:0050728]; negative regulation of late endosome to lysosome transport [GO:1902823]; neurotransmitter receptor transport, endosome to plasma membrane [GO:0099639]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein localization to cell periphery [GO:1904377]; protein localization to endosome [GO:0036010]; regulation of dendritic spine maintenance [GO:1902950]; regulation of protein stability [GO:0031647]; regulation of terminal button organization [GO:2000331]; retrograde transport, endosome to Golgi [GO:0042147]; transcytosis [GO:0045056]	D1 dopamine receptor binding [GO:0031748]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; late endosome [GO:0005770]; mitochondrion [GO:0005739]; mitochondrion-derived vesicle [GO:0099073]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422]	GO:0005739; GO:0005768; GO:0005769; GO:0005770; GO:0005829; GO:0010008; GO:0010628; GO:0030904; GO:0030906; GO:0031647; GO:0031748; GO:0032456; GO:0036010; GO:0042147; GO:0043653; GO:0045056; GO:0045732; GO:0050728; GO:0060161; GO:0090141; GO:0097422; GO:0099073; GO:0099074; GO:0099638; GO:0099639; GO:1902823; GO:1902950; GO:1904377; GO:2000331
GN003777	GN003777.1	Q78S06	48.6	105	111	156	5.20e-33	115	SYS1_MOUSE	Protein SYS1 homolog	Mus musculus (Mouse)	Golgi to endosome transport [GO:0006895]; Golgi to plasma membrane protein transport [GO:0043001]; protein localization to Golgi apparatus [GO:0034067]		cytosol [GO:0005829]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0005802; GO:0005829; GO:0006895; GO:0034067; GO:0043001
GN003778	GN003778.1	P80971	34.6	133	226	176	4.63e-16	76.3	COX42_THUOB	Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (Cytochrome c oxidase subunit IV isoform 2) (COX IV-2)	Thunnus obesus (Bigeye tuna)	mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]		mitochondrial inner membrane [GO:0005743]; respiratory chain complex IV [GO:0045277]	GO:0005743; GO:0006123; GO:0045277
GN003779	GN003779.1	Q9NUD7	26.4	265	373	363	8.33e-13	72.4	CT096_HUMAN	Uncharacterized protein C20orf96	Homo sapiens (Human)				
GN003780	GN003780.1	Q924T7	35.3	600	1721	1066	2.02e-100	352	RNF31_MOUSE	E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (Putative Ariadne-like ubiquitin ligase) (PAUL) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31)	Mus musculus (Mouse)	canonical NF-kappaB signal transduction [GO:0007249]; CD40 signaling pathway [GO:0023035]; defense response to bacterium [GO:0042742]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of necroptotic process [GO:0060546]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of xenophagy [GO:1904417]; protein linear polyubiquitination [GO:0097039]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; T cell receptor signaling pathway [GO:0050852]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; linear polyubiquitin binding [GO:1990450]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; LUBAC complex [GO:0071797]	GO:0000209; GO:0004842; GO:0005737; GO:0005829; GO:0007249; GO:0008270; GO:0009898; GO:0016567; GO:0023035; GO:0031625; GO:0033209; GO:0035631; GO:0036435; GO:0042742; GO:0042802; GO:0043123; GO:0043124; GO:0043130; GO:0050852; GO:0060546; GO:0061630; GO:0070530; GO:0071797; GO:0097039; GO:1904417; GO:1990450
GN003781	GN003781.1	E2RYF8	39.4	579	806	891	1.65e-95	321	TPX2_PATPE	Targeting protein for Xklp2 homolog (TPX2 homolog) (Microtubule-associated protein TPX2 homolog)	Patiria pectinifera (Starfish) (Asterina pectinifera)	regulation of mitotic spindle organization [GO:0060236]		microtubule [GO:0005874]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0005634; GO:0005819; GO:0005874; GO:0060236
GN003782	GN003782.1	C3YFB4	53.3	306	307	309	3.40e-100	299	DRE2_BRAFL	Anamorsin homolog (Fe-S cluster assembly protein DRE2 homolog)	Branchiostoma floridae (Florida lancelet) (Amphioxus)	iron-sulfur cluster assembly [GO:0016226]	2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]	cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]	GO:0005737; GO:0005758; GO:0009055; GO:0016226; GO:0051537
GN003784	GN003784.1	F1QXM5	62.6	455	492	497	1.96e-217	612	LDHD_DANRE	D-lactate dehydrogenase, mitochondrial (DLD) (Lactate dehydrogenase D) (EC 1.1.98.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	lactate catabolic process [GO:1903457]	(2R)-2-hydroxycarboxylate dehydrogenase activity [GO:0140174]; D-lactate dehydrogenase (FAD) activity [GO:0140170]; FAD binding [GO:0071949]	mitochondrion [GO:0005739]	GO:0005739; GO:0071949; GO:0140170; GO:0140174; GO:1903457
GN003785	GN003785.1	O46160	59.7	144	150	152	2.77e-47	153	RL14_LUMRU	Large ribosomal subunit protein eL14 (60S ribosomal protein L14)	Lumbricus rubellus (Humus earthworm)	ribosomal large subunit biogenesis [GO:0042273]; translation [GO:0006412]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]	GO:0003723; GO:0003735; GO:0006412; GO:0022625; GO:0042273
GN003786	GN003786.1	Q66J69	62.2	331	329	344	6.34e-127	369	RNG2A_XENLA	E3 ubiquitin-protein ligase RING2-A (EC 2.3.2.27) (RING finger protein 1B-A) (RING1b-A) (RING finger protein 2-A) (RING-type E3 ubiquitin transferase RING2-A)	Xenopus laevis (African clawed frog)	epigenetic regulation of gene expression [GO:0040029]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]	chromatin binding [GO:0003682]; histone H2AK119 ubiquitin ligase activity [GO:0140862]; ubiquitin protein ligase activity [GO:0061630]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; MLL1 complex [GO:0071339]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; ubiquitin ligase complex [GO:0000151]	GO:0000122; GO:0000151; GO:0003682; GO:0005634; GO:0005694; GO:0005737; GO:0016567; GO:0031519; GO:0035102; GO:0040029; GO:0045892; GO:0061630; GO:0071339; GO:0140862
GN003787	GN003787.1	O75521	56.2	356	358	394	5.69e-135	393	ECI2_HUMAN	Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1)	Homo sapiens (Human)	fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062]	delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; fatty-acyl-CoA binding [GO:0000062]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0000062; GO:0004165; GO:0005739; GO:0005777; GO:0005782; GO:0005829; GO:0006635; GO:0009062; GO:0016020
GN003788	GN003788.1	Q9D5D8	47.2	269	762	503	2.14e-70	242	CDYL2_MOUSE	Chromodomain Y-like protein 2 (CDY-like 2)	Mus musculus (Mouse)		histone H3K27me3 reader activity [GO:0061628]; histone H3K9me2/3 reader activity [GO:0062072]; transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]	GO:0003714; GO:0005634; GO:0061628; GO:0062072
GN003789	GN003789.1	Q922B6	33.2	503	598	594	1.23e-45	173	TRAF7_MOUSE	E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)	Mus musculus (Mouse)	apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to interleukin-6 [GO:0071354]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein K29-linked ubiquitination [GO:0035519]; protein ubiquitination [GO:0016567]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein localization [GO:0032880]; regulation of transcription by RNA polymerase II [GO:0006357]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	GO:0000122; GO:0000151; GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006357; GO:0006915; GO:0007249; GO:0008270; GO:0016567; GO:0031410; GO:0032880; GO:0033235; GO:0035519; GO:0043410; GO:0043525; GO:0048471; GO:0061630; GO:0070372; GO:0071354; GO:2000060; GO:2001235
GN003791	GN003791.1	P25932	64.1	92	310	470	4.68e-13	72.8	ESCA_DROME	Protein escargot (Protein fleabag)	Drosophila melanogaster (Fruit fly)	asymmetric neuroblast division [GO:0055059]; branch fusion, open tracheal system [GO:0035147]; cell fate determination [GO:0001709]; cell fate specification [GO:0001708]; central nervous system development [GO:0007417]; epithelial cell migration, open tracheal system [GO:0007427]; epithelial to mesenchymal transition [GO:0001837]; genital disc development [GO:0035215]; germ-line stem cell population maintenance [GO:0030718]; gravitaxis [GO:0042332]; intestinal stem cell homeostasis [GO:0036335]; maintenance of imaginal histoblast diploidy [GO:0007489]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; open tracheal system development [GO:0007424]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of compound eye pigmentation [GO:0048076]; regulation of DNA-templated transcription [GO:0006355]; regulation of neural precursor cell proliferation [GO:2000177]; response to nicotine [GO:0035094]; somatic stem cell population maintenance [GO:0035019]; wing disc development [GO:0035220]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000122; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0001708; GO:0001709; GO:0001837; GO:0002052; GO:0003677; GO:0005634; GO:0006355; GO:0007417; GO:0007424; GO:0007427; GO:0007489; GO:0030718; GO:0032876; GO:0035019; GO:0035094; GO:0035147; GO:0035215; GO:0035220; GO:0036335; GO:0042332; GO:0045892; GO:0045893; GO:0045944; GO:0048076; GO:0055059; GO:2000177
GN003792	GN003792.1	P58390	28.8	170	163	574	2.46e-14	72.8	KCNN2_MOUSE	Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)	Mus musculus (Mouse)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; modulation of chemical synaptic transmission [GO:0050804]; monoatomic ion transport [GO:0006811]; positive regulation of potassium ion transport [GO:0043268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of potassium ion transmembrane transport [GO:1901379]	alpha-actinin binding [GO:0051393]; calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; monoatomic ion channel activity [GO:0005216]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; small conductance calcium-activated potassium channel activity [GO:0016286]	cell surface [GO:0009986]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; smooth endoplasmic reticulum [GO:0005790]; T-tubule [GO:0030315]; Z disc [GO:0030018]	GO:0005216; GO:0005242; GO:0005516; GO:0005790; GO:0005886; GO:0006811; GO:0006813; GO:0009986; GO:0015269; GO:0016020; GO:0016286; GO:0019904; GO:0030018; GO:0030315; GO:0042383; GO:0042803; GO:0043025; GO:0043197; GO:0043268; GO:0045211; GO:0048168; GO:0050804; GO:0051393; GO:0071805; GO:0098914; GO:0098978; GO:1901379
GN003793	GN003793.1	P58390	35.6	418	459	574	2.21e-72	241	KCNN2_MOUSE	Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)	Mus musculus (Mouse)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; modulation of chemical synaptic transmission [GO:0050804]; monoatomic ion transport [GO:0006811]; positive regulation of potassium ion transport [GO:0043268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of potassium ion transmembrane transport [GO:1901379]	alpha-actinin binding [GO:0051393]; calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; monoatomic ion channel activity [GO:0005216]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; small conductance calcium-activated potassium channel activity [GO:0016286]	cell surface [GO:0009986]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; smooth endoplasmic reticulum [GO:0005790]; T-tubule [GO:0030315]; Z disc [GO:0030018]	GO:0005216; GO:0005242; GO:0005516; GO:0005790; GO:0005886; GO:0006811; GO:0006813; GO:0009986; GO:0015269; GO:0016020; GO:0016286; GO:0019904; GO:0030018; GO:0030315; GO:0042383; GO:0042803; GO:0043025; GO:0043197; GO:0043268; GO:0045211; GO:0048168; GO:0050804; GO:0051393; GO:0071805; GO:0098914; GO:0098978; GO:1901379
GN003794	GN003794.1	P58390	33.3	414	487	574	6.05e-74	246	KCNN2_MOUSE	Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)	Mus musculus (Mouse)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; modulation of chemical synaptic transmission [GO:0050804]; monoatomic ion transport [GO:0006811]; positive regulation of potassium ion transport [GO:0043268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of potassium ion transmembrane transport [GO:1901379]	alpha-actinin binding [GO:0051393]; calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; monoatomic ion channel activity [GO:0005216]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; small conductance calcium-activated potassium channel activity [GO:0016286]	cell surface [GO:0009986]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; smooth endoplasmic reticulum [GO:0005790]; T-tubule [GO:0030315]; Z disc [GO:0030018]	GO:0005216; GO:0005242; GO:0005516; GO:0005790; GO:0005886; GO:0006811; GO:0006813; GO:0009986; GO:0015269; GO:0016020; GO:0016286; GO:0019904; GO:0030018; GO:0030315; GO:0042383; GO:0042803; GO:0043025; GO:0043197; GO:0043268; GO:0045211; GO:0048168; GO:0050804; GO:0051393; GO:0071805; GO:0098914; GO:0098978; GO:1901379
GN003795	GN003795.1	Q99L04	51.3	318	314	313	1.63e-113	333	DHRS1_MOUSE	Dehydrogenase/reductase SDR family member 1 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 19C member 1) (Protein SDR19C1)	Mus musculus (Mouse)		carbonyl reductase (NADPH) activity [GO:0004090]; estradiol 17-alpha-dehydrogenase [NAD(P)+] activity [GO:0047881]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; testosterone dehydrogenase (NADP+) activity [GO:0047045]	endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0004090; GO:0005739; GO:0005743; GO:0005783; GO:0016616; GO:0047045; GO:0047881
GN003796	GN003796.1	Q9CR22	37.8	127	142	157	4.19e-15	70.9	TMM42_MOUSE	Transmembrane protein 42	Mus musculus (Mouse)			membrane [GO:0016020]	GO:0016020
GN003797	GN003797.1	Q04310	36.5	181	196	221	5.66e-31	115	Y4629_STRCO	Uncharacterized protein SCO4629	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)			plasma membrane [GO:0005886]	GO:0005886
GN003798	GN003798.1	Q503C8	39.4	594	589	585	6.40e-133	403	NUDC1_DANRE	NudC domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN003799	GN003799.1	Q8BZ25	35.1	276	737	745	6.89e-35	145	ANKK1_MOUSE	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1)	Mus musculus (Mouse)	cellular response to retinoic acid [GO:0071300]; regulation of cell cycle process [GO:0010564]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0010564; GO:0071300; GO:0106310
GN003801	GN003801.1	Q13546	35.1	111	183	671	7.88e-10	60.5	RIPK1_HUMAN	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)	Homo sapiens (Human)	activation of protein kinase activity [GO:0032147]; amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to tumor necrosis factor [GO:0071356]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of necroptotic process [GO:0060546]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of miRNA processing [GO:1903800]; positive regulation of necroptotic process [GO:0060545]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of programmed cell death [GO:0043068]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; response to oxidative stress [GO:0006979]; response to tumor necrosis factor [GO:0034612]; ripoptosome assembly [GO:0097343]; ripoptosome assembly involved in necroptotic process [GO:1901026]; T cell apoptotic process [GO:0070231]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	ATP binding [GO:0005524]; death domain binding [GO:0070513]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase binding [GO:0120283]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]; signaling adaptor activity [GO:0035591]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ripoptosome [GO:0097342]; signaling receptor complex [GO:0043235]; tumor necrosis factor receptor superfamily complex [GO:0002947]	GO:0002947; GO:0004672; GO:0004674; GO:0004706; GO:0004722; GO:0005123; GO:0005524; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006915; GO:0006954; GO:0006979; GO:0007249; GO:0008625; GO:0008630; GO:0010008; GO:0010628; GO:0031264; GO:0031625; GO:0032147; GO:0032757; GO:0032760; GO:0032991; GO:0033209; GO:0034612; GO:0035556; GO:0035591; GO:0042802; GO:0042803; GO:0043065; GO:0043066; GO:0043068; GO:0043123; GO:0043124; GO:0043235; GO:0043525; GO:0044877; GO:0045651; GO:0045944; GO:0046330; GO:0050729; GO:0060545; GO:0060546; GO:0062100; GO:0070105; GO:0070231; GO:0070266; GO:0070301; GO:0070513; GO:0071356; GO:0071363; GO:0097191; GO:0097300; GO:0097342; GO:0097343; GO:0097527; GO:0106310; GO:0120283; GO:1900119; GO:1901026; GO:1901224; GO:1903265; GO:1903800; GO:1990000; GO:2000379; GO:2001237; GO:2001238; GO:2001240
GN003802	GN003802.1	Q04861	35.6	194	337	983	1.17e-26	114	NFKB1_CHICK	Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]	Gallus gallus (Chicken)	canonical NF-kappaB signal transduction [GO:0007249]; positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; NF-kappaB binding [GO:0051059]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; NF-kappaB p50/p65 complex [GO:0035525]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0005737; GO:0007249; GO:0035525; GO:0045944; GO:0051059
GN003807	GN003807.1	Q5R4X4	45.3	258	273	291	2.11e-61	198	SSRA_PONAB	Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)			endoplasmic reticulum membrane [GO:0005789]	GO:0005789
GN003808	GN003808.1	Q63540	63.0	135	544	789	8.30e-43	166	ATX1_RAT	Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog)	Rattus norvegicus (Rat)	adult locomotory behavior [GO:0008344]; brain development [GO:0007420]; excitatory postsynaptic potential [GO:0060079]; learning [GO:0007612]; lung alveolus development [GO:0048286]; memory [GO:0007613]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of phosphorylation [GO:0042326]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear export [GO:0051168]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of transcription by RNA polymerase II [GO:0045944]; social behavior [GO:0035176]; visual learning [GO:0008542]	chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; POZ domain binding [GO:0031208]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear inclusion body [GO:0042405]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]	GO:0000122; GO:0003682; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0007420; GO:0007612; GO:0007613; GO:0008266; GO:0008344; GO:0008542; GO:0016363; GO:0031208; GO:0032991; GO:0034046; GO:0035176; GO:0042326; GO:0042405; GO:0042802; GO:0043569; GO:0045892; GO:0045944; GO:0048286; GO:0051168; GO:0060079; GO:0060252; GO:0098794
GN003810	GN003810.1	Q6DC53	41.6	471	581	501	4.21e-101	318	CTU2_DANRE	Cytoplasmic tRNA 2-thiolation protein 2	Danio rerio (Zebrafish) (Brachydanio rerio)	protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble position uridine thiolation [GO:0002143]; tRNA wobble uridine modification [GO:0002098]	nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]	cytosol [GO:0005829]	GO:0000049; GO:0002098; GO:0002143; GO:0005829; GO:0016779; GO:0032447; GO:0034227
GN003811	GN003811.1	Q9D0S4	40.7	275	264	285	2.12e-54	180	NEUL2_MOUSE	Neuralized-like protein 2	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; myofibril assembly [GO:0030239]; protein ubiquitination [GO:0016567]; sarcomere organization [GO:0045214]	ubiquitin protein ligase activity [GO:0061630]	muscle tendon junction [GO:0005927]; VCB complex [GO:0030891]	GO:0005927; GO:0016567; GO:0030239; GO:0030891; GO:0035556; GO:0045214; GO:0061630
GN003813	GN003813.1	E9QAM5	26.6	1722	1947	2947	4.71e-142	496	HELZ2_MOUSE	3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 5.6.2.6) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1)	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of lipid metabolic process [GO:0019216]	3'-5' RNA helicase activity [GO:0034458]; ATP hydrolysis activity [GO:0016887]; exoribonuclease II activity [GO:0008859]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P granule [GO:0043186]	GO:0003723; GO:0003724; GO:0005654; GO:0005737; GO:0005829; GO:0008859; GO:0016887; GO:0019216; GO:0034458; GO:0043186; GO:0045944
GN003814	GN003814.1	E9QAM5	41.8	201	196	2947	3.98e-39	145	HELZ2_MOUSE	3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 5.6.2.6) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1)	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of lipid metabolic process [GO:0019216]	3'-5' RNA helicase activity [GO:0034458]; ATP hydrolysis activity [GO:0016887]; exoribonuclease II activity [GO:0008859]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P granule [GO:0043186]	GO:0003723; GO:0003724; GO:0005654; GO:0005737; GO:0005829; GO:0008859; GO:0016887; GO:0019216; GO:0034458; GO:0043186; GO:0045944
GN003818	GN003818.1	Q6ZU67	46.3	67	131	534	2.83e-11	62.8	BEND4_HUMAN	BEN domain-containing protein 4 (Coiled-coil domain-containing protein 4)	Homo sapiens (Human)		DNA binding [GO:0003677]		GO:0003677
GN003823	GN003823.1	P35240	59.2	591	600	595	1.20e-196	567	MERL_HUMAN	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; hippo signaling [GO:0035329]; lens fiber cell differentiation [GO:0070306]; negative regulation of cell growth involved in contact inhibition [GO:0060243]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of stress fiber assembly [GO:0051496]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell shape [GO:0008360]; regulation of gliogenesis [GO:0014013]; regulation of hippo signaling [GO:0035330]; regulation of organelle assembly [GO:1902115]; Schwann cell proliferation [GO:0014010]	actin binding [GO:0003779]; integrin binding [GO:0005178]; signaling adaptor activity [GO:0035591]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; cell body [GO:0044297]; cleavage furrow [GO:0032154]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	GO:0001953; GO:0003779; GO:0005178; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005769; GO:0005829; GO:0005856; GO:0005886; GO:0005912; GO:0008285; GO:0008360; GO:0014010; GO:0014013; GO:0016020; GO:0022408; GO:0030027; GO:0030036; GO:0030175; GO:0030336; GO:0030864; GO:0031527; GO:0032154; GO:0032587; GO:0035329; GO:0035330; GO:0035591; GO:0042981; GO:0043005; GO:0044297; GO:0045177; GO:0046426; GO:0048471; GO:0051496; GO:0051726; GO:0060243; GO:0070306; GO:1902115; GO:1902966; GO:2000643
GN003825	GN003825.1	Q5I0P2	58.8	136	163	170	1.10e-51	165	GCSH_RAT	Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)	Rattus norvegicus (Rat)	glycine decarboxylation via glycine cleavage system [GO:0019464]	aminomethyltransferase activity [GO:0004047]; enzyme binding [GO:0019899]	glycine cleavage complex [GO:0005960]; mitochondrion [GO:0005739]	GO:0004047; GO:0005739; GO:0005960; GO:0019464; GO:0019899
GN003826	GN003826.1	Q4V7D6	43.1	350	333	376	1.62e-92	283	NIF3L_RAT	NIF3-like protein 1	Rattus norvegicus (Rat)	negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]	identical protein binding [GO:0042802]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0000122; GO:0005634; GO:0005737; GO:0005739; GO:0030182; GO:0042802; GO:0045893; GO:0061629
GN003827	GN003827.1	Q8BJK1	47.3	150	272	289	4.82e-34	127	KCTD7_MOUSE	BTB/POZ domain-containing protein KCTD7	Mus musculus (Mouse)	intracellular glutamate homeostasis [GO:0090461]; intracellular potassium ion homeostasis [GO:0030007]; membrane hyperpolarization [GO:0060081]; positive regulation of transporter activity [GO:0032411]; protein homooligomerization [GO:0051260]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0005737; GO:0005829; GO:0005886; GO:0030007; GO:0032411; GO:0042802; GO:0051260; GO:0060081; GO:0090461
GN003828	GN003828.1	Q6PAY6	41.2	434	540	466	7.21e-104	323	HYPDH_XENLA	Hydroxyproline dehydrogenase (HYPDH) (EC 1.5.5.3) (Probable proline dehydrogenase 2) (EC 1.5.5.2) (Probable proline oxidase 2)	Xenopus laevis (African clawed frog)	L-proline catabolic process [GO:0006562]	FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-NH group of donors [GO:0016645]; proline dehydrogenase activity [GO:0004657]	mitochondrion [GO:0005739]	GO:0004657; GO:0005739; GO:0006562; GO:0016645; GO:0071949
GN003837	GN003837.1	Q9UDX5	56.7	60	86	166	1.32e-13	65.1	MTFP1_HUMAN	Mitochondrial fission process protein 1 (Mitochondrial 18 kDa protein) (MTP18)	Homo sapiens (Human)	mitochondrial fission [GO:0000266]; negative regulation of mitochondrial fusion [GO:0010637]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0000266; GO:0005739; GO:0005743; GO:0010637
GN003840	GN003840.1	Q5ZJI0	59.8	333	372	371	1.40e-143	414	TPST2_CHICK	Protein-tyrosine sulfotransferase 2 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 2) (TPST-2)	Gallus gallus (Chicken)	peptidyl-tyrosine sulfation [GO:0006478]	protein-tyrosine sulfotransferase activity [GO:0008476]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005794; GO:0006478; GO:0008476
GN003843	GN003843.1	Q8BIY1	44.6	543	523	525	5.39e-124	376	GPTC3_MOUSE	G patch domain-containing protein 3	Mus musculus (Mouse)	negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; positive regulation of DNA-templated transcription [GO:0045893]	nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003676; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0032480; GO:0039536; GO:0045893
GN003844	GN003844.1	Q8N5S9	58.4	423	882	505	1.49e-159	479	KKCC1_HUMAN	Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha)	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]	ATP binding [GO:0005524]; calcium/calmodulin-dependent protein kinase activity [GO:0004683]; calmodulin binding [GO:0005516]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0004683; GO:0005516; GO:0005524; GO:0005654; GO:0005737; GO:0005829; GO:0035556; GO:0106310
GN003846	GN003846.1	Q22795	38.3	141	1013	242	1.09e-22	101	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN003847	GN003847.1	Q22795	38.3	141	984	242	1.05e-22	101	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN003848	GN003848.1	Q22795	38.3	141	984	242	1.05e-22	101	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN003849	GN003849.1	Q22795	38.3	141	984	242	1.05e-22	101	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN003852	GN003852.1	Q22795	38.3	141	1181	242	1.31e-22	101	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN003856	GN003856.1	Q99KX1	48.1	162	229	247	4.31e-29	112	MLF2_MOUSE	Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2)	Mus musculus (Mouse)	regulation of DNA-templated transcription [GO:0006355]		cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; synapse [GO:0045202]	GO:0005634; GO:0005737; GO:0006355; GO:0045202; GO:0098978
GN003867	GN003867.1	Q5TAA0	23.8	525	759	569	1.17e-10	68.6	TTC22_HUMAN	Tetratricopeptide repeat protein 22 (TPR repeat protein 22)	Homo sapiens (Human)				
GN003868	GN003868.1	Q96AY4	49.5	872	2612	2481	3.44e-227	755	TTC28_HUMAN	Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio)	Homo sapiens (Human)	regulation of mitotic cell cycle [GO:0007346]	kinase binding [GO:0019900]	centrosome [GO:0005813]; midbody [GO:0030496]; spindle pole [GO:0000922]	GO:0000922; GO:0005813; GO:0007346; GO:0019900; GO:0030496
GN003870	GN003870.1	Q6DCX5	28.6	308	381	463	3.29e-31	126	PCFT_XENLA	Proton-coupled folate transporter (Heme carrier protein 1) (Solute carrier family 46 member 1)	Xenopus laevis (African clawed frog)	transmembrane transport [GO:0055085]	methotrexate transmembrane transporter activity [GO:0015350]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	GO:0005737; GO:0005768; GO:0005886; GO:0010008; GO:0015293; GO:0015350; GO:0016323; GO:0016324; GO:0022857; GO:0055085
GN003873	GN003873.1	Q6DCX5	28.0	304	381	463	6.22e-31	125	PCFT_XENLA	Proton-coupled folate transporter (Heme carrier protein 1) (Solute carrier family 46 member 1)	Xenopus laevis (African clawed frog)	transmembrane transport [GO:0055085]	methotrexate transmembrane transporter activity [GO:0015350]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	GO:0005737; GO:0005768; GO:0005886; GO:0010008; GO:0015293; GO:0015350; GO:0016323; GO:0016324; GO:0022857; GO:0055085
GN003875	GN003875.1	P41154	41.7	429	508	451	5.15e-83	267	HSF_XENLA	Heat shock factor protein (HSF) (Heat shock transcription factor) (HSTF)	Xenopus laevis (African clawed frog)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0003700; GO:0005634; GO:0006357
GN003876	GN003876.1	Q5R662	40.1	501	769	859	3.50e-83	286	LRP12_PONAB	Low-density lipoprotein receptor-related protein 12 (LRP-12)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	neuron migration [GO:0001764]; neuron projection development [GO:0031175]; vesicle-mediated transport [GO:0016192]	integrin binding [GO:0005178]	plasma membrane [GO:0005886]	GO:0001764; GO:0005178; GO:0005886; GO:0016192; GO:0031175
GN003892	GN003892.1	Q61909	56.2	283	352	577	4.74e-78	253	MTG8_MOUSE	Protein CBFA2T1 (Protein MTG8)	Mus musculus (Mouse)	DNA-templated transcription [GO:0006351]; fat cell differentiation [GO:0045444]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron projection development [GO:0010977]; regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]	nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	GO:0003714; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0010977; GO:0016363; GO:0017053; GO:0042802; GO:0045444; GO:0045599; GO:0045892; GO:0140297
GN003893	GN003893.1	Q61909	60.8	97	216	577	7.31e-33	127	MTG8_MOUSE	Protein CBFA2T1 (Protein MTG8)	Mus musculus (Mouse)	DNA-templated transcription [GO:0006351]; fat cell differentiation [GO:0045444]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron projection development [GO:0010977]; regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]	nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	GO:0003714; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0010977; GO:0016363; GO:0017053; GO:0042802; GO:0045444; GO:0045599; GO:0045892; GO:0140297
GN003894	GN003894.1	Q0P8I7	41.2	308	318	313	1.48e-76	239	GMHD_CAMJE	GDP-D-glycero-alpha-D-manno-heptose dehydrogenase (EC 1.1.98.-)	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	capsule polysaccharide biosynthetic process [GO:0045227]; protein homotetramerization [GO:0051289]	GDP binding [GO:0019003]; identical protein binding [GO:0042802]; NADH binding [GO:0070404]		GO:0019003; GO:0042802; GO:0045227; GO:0051289; GO:0070404
GN003897	GN003897.1	Q9C5S2	23.1	308	1600	841	1.39e-12	76.6	IRE1A_ARATH	Serine/threonine-protein kinase/endoribonuclease IRE1a (Endoplasmic reticulum-to-nucleus signaling 1-2) (Inositol-requiring protein 1-2) (AtIRE1-2) (Serine/threonine-protein kinase/endoribonuclease IRE1-2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]	Arabidopsis thaliana (Mouse-ear cress)	defense response to bacterium [GO:0042742]; endoplasmic reticulum unfolded protein response [GO:0030968]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; mRNA processing [GO:0006397]; protein autophosphorylation [GO:0046777]; response to endoplasmic reticulum stress [GO:0034976]; response to salicylic acid [GO:0009751]; RNA splicing [GO:0008380]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA endonuclease activity [GO:0004521]	chloroplast [GO:0009507]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; secretory vesicle [GO:0099503]	GO:0004521; GO:0004674; GO:0005524; GO:0005783; GO:0005789; GO:0006397; GO:0008380; GO:0009507; GO:0009751; GO:0030968; GO:0034976; GO:0036498; GO:0042742; GO:0046777; GO:0070059; GO:0099503; GO:0106310
GN003898	GN003898.1	Q1MTD4	38.2	165	283	242	9.13e-26	105	CR19A_DANRE	Uncharacterized protein C18orf19 homolog A	Danio rerio (Zebrafish) (Brachydanio rerio)			membrane [GO:0016020]; mitochondrion [GO:0005739]	GO:0005739; GO:0016020
GN003905	GN003905.1	Q6UX40	51.8	85	88	140	1.27e-26	97.8	TM107_HUMAN	Transmembrane protein 107	Homo sapiens (Human)	cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]		ciliary transition zone [GO:0035869]; membrane [GO:0016020]; MKS complex [GO:0036038]	GO:0016020; GO:0021532; GO:0035869; GO:0036038; GO:0042733; GO:0060271; GO:1904491; GO:1905515
GN003906	GN003906.1	O35142	73.6	933	942	905	0.0	1207	COPB2_RAT	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102)	Rattus norvegicus (Rat)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	protein kinase C binding [GO:0005080]; structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005080; GO:0005198; GO:0005794; GO:0005829; GO:0006886; GO:0006888; GO:0006890; GO:0006891; GO:0030126
GN003907	GN003907.1	Q13029	42.5	127	2104	1718	1.60e-18	97.1	PRDM2_HUMAN	PR domain zinc finger protein 2 (EC 2.1.1.-) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 trimethyltransferase activity [GO:0140949]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000977; GO:0000981; GO:0001227; GO:0001228; GO:0003700; GO:0005634; GO:0005654; GO:0006355; GO:0006357; GO:0008270; GO:0043565; GO:0045944; GO:0046974; GO:0140949
GN003908	GN003908.1	Q15427	87.4	215	405	424	3.47e-133	391	SF3B4_HUMAN	Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49)	Homo sapiens (Human)	mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal snRNP assembly [GO:0000387]; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [GO:0000388]; U2-type prespliceosome assembly [GO:1903241]	RNA binding [GO:0003723]; splicing factor binding [GO:1990935]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U11/U12 snRNP [GO:0034693]; U12-type catalytic step 2 spliceosome [GO:0071018]; U12-type precatalytic spliceosome [GO:0071016]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	GO:0000375; GO:0000387; GO:0000388; GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005684; GO:0005686; GO:0005689; GO:0006397; GO:0008380; GO:0034693; GO:0071005; GO:0071006; GO:0071011; GO:0071016; GO:0071018; GO:1903241; GO:1990935
GN003913	GN003913.1	Q7Z5L3	34.4	93	177	287	2.79e-09	58.2	C1QL2_HUMAN	Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; regulation of synapse maturation [GO:0090128]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0032991; GO:0042802; GO:0043083; GO:0045202; GO:0090128; GO:0097107; GO:0098686; GO:0099550; GO:0099558; GO:0099645; GO:0150053
GN003914	GN003914.1	Q5VWW1	32.1	131	211	255	3.10e-12	67.0	C1QL3_HUMAN	Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0097107; GO:0098686; GO:0098978; GO:0099550; GO:0099558; GO:0099645
GN003917	GN003917.1	Q9QYJ0	53.3	426	416	412	2.44e-133	392	DNJA2_MOUSE	DnaJ homolog subfamily A member 2 (mDj3)	Mus musculus (Mouse)	cellular response to heat [GO:0034605]; protein refolding [GO:0042026]	ATP binding [GO:0005524]; ATPase activator activity [GO:0001671]; Hsp70 protein binding [GO:0030544]; protein-folding chaperone binding [GO:0051087]	cytosol [GO:0005829]; membrane [GO:0016020]	GO:0001671; GO:0005524; GO:0005829; GO:0016020; GO:0030544; GO:0034605; GO:0042026; GO:0051087
GN003918	GN003918.1	Q5ZL13	38.6	365	392	378	4.04e-78	248	NUD19_CHICK	Acyl-coenzyme A diphosphatase NUDT19 (EC 3.6.1.-) (EC 3.6.1.77) (Nucleoside diphosphate-linked moiety X motif 19) (Nudix motif 19)	Gallus gallus (Chicken)	butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; propionyl-CoA metabolic process [GO:1902858]; succinyl-CoA catabolic process [GO:1901289]	coenzyme A diphosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287]	peroxisome [GO:0005777]	GO:0000287; GO:0005777; GO:0010945; GO:0015938; GO:0036114; GO:0044580; GO:1901289; GO:1902858; GO:2001294
GN003919	GN003919.1	P12955	64.8	474	499	493	1.29e-235	658	PEPD_HUMAN	Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase)	Homo sapiens (Human)	amino acid metabolic process [GO:0006520]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]	manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metallocarboxypeptidase activity [GO:0004181]; proline dipeptidase activity [GO:0102009]	extracellular exosome [GO:0070062]	GO:0004181; GO:0006508; GO:0006520; GO:0030145; GO:0043069; GO:0070006; GO:0070062; GO:0102009
GN003921	GN003921.1	P00521	24.9	249	704	746	8.92e-13	75.5	ABL_MLVAB	Tyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl)	Abelson murine leukemia virus		ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]		GO:0004715; GO:0005524
GN003922	GN003922.1	Q7ZY69	55.2	580	599	574	3.35e-188	545	PESC_XENLA	Pescadillo homolog	Xenopus laevis (African clawed frog)	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of cell cycle [GO:0051726]	ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]	GO:0000463; GO:0000466; GO:0003723; GO:0005654; GO:0005730; GO:0030687; GO:0043021; GO:0051726; GO:0070545
GN003923	GN003923.1	Q9DB15	55.9	143	194	201	1.02e-38	134	RM12_MOUSE	Large ribosomal subunit protein bL12m (39S ribosomal protein L12, mitochondrial) (L12mt) (MRP-L12) [Cleaved into: Large ribosomal subunit protein bL12m, long mature form; Large ribosomal subunit protein bL12m, short mature form]	Mus musculus (Mouse)	mitochondrial transcription [GO:0006390]; mitochondrial translation [GO:0032543]; positive regulation of DNA-templated transcription [GO:0045893]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial matrix [GO:0005759]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005759; GO:0005761; GO:0005762; GO:0006390; GO:0006412; GO:0032543; GO:0045893
GN003924	GN003924.1	P51871	40.7	462	932	537	8.99e-108	347	CP4F6_RAT	Cytochrome P450 4F6 (EC 1.14.14.1) (CYPIVF6)	Rattus norvegicus (Rat)	leukotriene metabolic process [GO:0006691]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005789; GO:0006691; GO:0016712; GO:0020037
GN003926	GN003926.1	E9QHT9	27.0	174	241	185	2.30e-09	58.5	PERP_DANRE	p53 apoptosis effector related to PMP-22	Danio rerio (Zebrafish) (Brachydanio rerio)	apoptotic process involved in blood vessel morphogenesis [GO:1902262]; cell-cell adhesion [GO:0098609]; regulation of apoptotic process [GO:0042981]; response to UV [GO:0009411]		cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0005911; GO:0009411; GO:0030057; GO:0042981; GO:0098609; GO:1902262
GN003928	GN003928.1	B0BM36	78.8	198	204	284	3.44e-120	345	SDHB_XENTR	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip) (Malate dehydrogenase [quinone] iron-sulfur subunit) (EC 1.1.5.-)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	aerobic respiration [GO:0009060]; respiratory electron transport chain [GO:0022904]; tricarboxylic acid cycle [GO:0006099]	2 iron, 2 sulfur cluster binding [GO:0051537]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; succinate dehydrogenase (quinone) activity [GO:0008177]; ubiquinone binding [GO:0048039]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; respiratory chain complex II (succinate dehydrogenase) [GO:0045273]	GO:0005743; GO:0006099; GO:0008177; GO:0009055; GO:0009060; GO:0022904; GO:0031966; GO:0045273; GO:0048039; GO:0051537; GO:0051538; GO:0051539
GN003929	GN003929.1	B1AZ99	48.9	266	404	396	4.76e-68	223	OTUD3_MOUSE	OTU domain-containing protein 3 (EC 3.4.19.12)	Mus musculus (Mouse)	cellular response to nutrient levels [GO:0031669]; energy homeostasis [GO:0097009]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K27-linked deubiquitination [GO:1990167]; protein K48-linked deubiquitination [GO:0071108]; protein K6-linked deubiquitination [GO:0044313]; protein stabilization [GO:0050821]; regulation of transcription by RNA polymerase II [GO:0006357]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome disassembly [GO:0032790]	cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004843; GO:0005634; GO:0005737; GO:0006357; GO:0016579; GO:0031669; GO:0032790; GO:0035871; GO:0044313; GO:0050821; GO:0051898; GO:0071108; GO:0072344; GO:0097009; GO:1990167
GN003930	GN003930.1	Q7F0J0	43.8	146	222	169	1.01e-32	119	CML13_ORYSJ	Probable calcium-binding protein CML13 (Calmodulin-like protein 13)	Oryza sativa subsp. japonica (Rice)	microtubule cytoskeleton organization [GO:0000226]	calcium ion binding [GO:0005509]	centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000226; GO:0005509; GO:0005634; GO:0005737; GO:0005814
GN003931	GN003931.1	P46197	58.3	230	330	1047	1.29e-75	254	ANPRB_BOVIN	Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B)	Bos taurus (Bovine)	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; identical protein binding [GO:0042802]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; protein kinase activity [GO:0004672]	plasma membrane [GO:0005886]	GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0006182; GO:0007168; GO:0016941; GO:0017046; GO:0035556; GO:0042802
GN003932	GN003932.1	P10447	24.9	241	1293	439	1.39e-11	72.0	ABL_FSVHY	Tyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl)	Feline sarcoma virus (strain Hardy-Zuckerman 2)	cell communication [GO:0007154]; signaling [GO:0023052]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]		GO:0004715; GO:0005524; GO:0007154; GO:0023052
GN003933	GN003933.1	Q13882	29.1	244	1242	451	2.33e-19	96.3	PTK6_HUMAN	Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK)	Homo sapiens (Human)	cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to retinoic acid [GO:0071300]; ERBB2 signaling pathway [GO:0038128]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of growth [GO:0045926]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA replication [GO:0045740]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of neuron projection development [GO:0010976]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; tyrosine phosphorylation of STAT protein [GO:0007260]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GO:0001726; GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006468; GO:0007169; GO:0007260; GO:0010976; GO:0016477; GO:0016604; GO:0030154; GO:0038128; GO:0042802; GO:0045740; GO:0045742; GO:0045787; GO:0045926; GO:0046427; GO:0046777; GO:0060575; GO:0061099; GO:0071300
GN003934	GN003934.1	P16580	75.8	165	165	373	6.12e-94	280	GLNA_CHICK	Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate decarboxylase) (EC 4.1.1.15) (Glutamate--ammonia ligase) (p42)	Gallus gallus (Chicken)		glutamate decarboxylase activity [GO:0004351]; glutamine synthetase activity [GO:0004356]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0004351; GO:0004356; GO:0005737; GO:0005739
GN003935	GN003935.1	P16580	75.8	165	165	373	6.12e-94	280	GLNA_CHICK	Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate decarboxylase) (EC 4.1.1.15) (Glutamate--ammonia ligase) (p42)	Gallus gallus (Chicken)		glutamate decarboxylase activity [GO:0004351]; glutamine synthetase activity [GO:0004356]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0004351; GO:0004356; GO:0005737; GO:0005739
GN003936	GN003936.1	P15103	75.7	239	287	373	3.59e-146	417	GLNA_BOVIN	Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225)	Bos taurus (Bovine)	intracellular ammonium homeostasis [GO:0097275]; positive regulation of erythrocyte differentiation [GO:0045648]; protein palmitoylation [GO:0018345]; regulation of endothelial cell migration [GO:0010594]; regulation of sprouting angiogenesis [GO:1903670]	glutamine synthetase activity [GO:0004356]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0004356; GO:0005739; GO:0005829; GO:0005886; GO:0010594; GO:0018345; GO:0019706; GO:0045648; GO:0097275; GO:1903670
GN003941	GN003941.1	Q9P2Z0	35.3	102	624	257	3.46e-12	70.5	THA10_HUMAN	THAP domain-containing protein 10	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]		GO:0043565
GN003945	GN003945.1	P61584	61.1	149	164	1003	1.03e-56	194	ROCK1_PANTR	Rho-associated protein kinase 1 (EC 2.7.11.39) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)	Pan troglodytes (Chimpanzee)	actomyosin structure organization [GO:0031032]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; mitotic cytokinesis [GO:0000281]; myoblast migration [GO:0051451]; positive regulation of focal adhesion assembly [GO:0051894]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell junction assembly [GO:1901888]; regulation of cell migration [GO:0030334]; regulation of microtubule cytoskeleton organization [GO:0070507]; Rho protein signal transduction [GO:0007266]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; small GTPase binding [GO:0031267]	bleb [GO:0032059]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GO:0000139; GO:0000281; GO:0001726; GO:0004674; GO:0005524; GO:0005737; GO:0005814; GO:0005856; GO:0005886; GO:0007266; GO:0010494; GO:0030027; GO:0030334; GO:0030866; GO:0031032; GO:0031267; GO:0032059; GO:0032956; GO:0048598; GO:0051451; GO:0051894; GO:0070507; GO:0072518; GO:0106310; GO:1901888
GN003948	GN003948.1	P29030	49.0	49	356	504	3.66e-10	64.7	CHIT_BRUMA	Endochitinase (EC 3.2.1.14) (MF1 antigen)	Brugia malayi (Filarial nematode worm)	carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]	chitin binding [GO:0008061]; endochitinase activity [GO:0008843]	extracellular region [GO:0005576]	GO:0005576; GO:0005975; GO:0006032; GO:0008061; GO:0008843
GN003950	GN003950.1	Q96GQ5	66.0	141	186	468	1.71e-57	190	RUSF1_HUMAN	RUS family member 1	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN003951	GN003951.1	Q9D0F6	72.4	261	263	339	7.26e-134	384	RFC5_MOUSE	Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)	Mus musculus (Mouse)	DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; enzyme binding [GO:0019899]; single-stranded DNA helicase activity [GO:0017116]	Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleus [GO:0005634]; Rad17 RFC-like complex [GO:0031389]	GO:0003677; GO:0003689; GO:0005524; GO:0005634; GO:0005663; GO:0006261; GO:0006281; GO:0016887; GO:0017116; GO:0019899; GO:0031389; GO:0031390; GO:1900264
GN003956	GN003956.1	Q5EAJ7	72.5	854	856	857	0.0	1129	MVP_STRPU	Major vault protein (MVP)	Strongylocentrotus purpuratus (Purple sea urchin)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN003957	GN003957.1	Q9M146	24.7	271	348	360	1.83e-14	77.0	MGP4_ARATH	UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase MGP4 (EC 2.4.2.-) (Protein MALE GAMETOPHYTE DEFECTIVE 4) (Rhamnogalacturonan xylosyltransferase MGP4)	Arabidopsis thaliana (Mouse-ear cress)	pollen tube development [GO:0048868]; rhamnogalacturonan II biosynthetic process [GO:0010306]	xylosyltransferase activity [GO:0042285]	chloroplast [GO:0009507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]	GO:0000138; GO:0000139; GO:0005794; GO:0009507; GO:0010306; GO:0042285; GO:0048868
GN003958	GN003958.1	A1L0Y2	48.5	1508	1444	1477	0.0	1355	NEUL4_XENTR	Neuralized-like protein 4	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mitochondrial DNA repair [GO:0043504]	ubiquitin protein ligase activity [GO:0061630]	centriole [GO:0005814]; mitochondrion [GO:0005739]	GO:0005739; GO:0005814; GO:0043504; GO:0061630
GN003959	GN003959.1	Q98943	24.1	316	424	424	2.29e-21	99.0	CASP2_CHICK	Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]	Gallus gallus (Chicken)	apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]	cysteine-type endopeptidase activity [GO:0004197]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]; endopeptidase complex [GO:1905369]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0004197; GO:0005634; GO:0005737; GO:0005739; GO:0006915; GO:0008630; GO:0016485; GO:0019904; GO:0030330; GO:0042802; GO:0043525; GO:0071260; GO:0097192; GO:1905369
GN003970	GN003970.1	Q3ZBL5	54.5	165	218	179	3.45e-54	174	PTH2_BOVIN	Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription)	Bos taurus (Bovine)	negative regulation of anoikis [GO:2000811]; positive regulation of anoikis [GO:2000210]	peptidyl-tRNA hydrolase activity [GO:0004045]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]	GO:0004045; GO:0005741; GO:0005829; GO:2000210; GO:2000811
GN003971	GN003971.1	Q803E1	44.6	74	782	694	1.47e-13	78.2	NCBP3_DANRE	Nuclear cap-binding protein subunit 3	Danio rerio (Zebrafish) (Brachydanio rerio)		mRNA binding [GO:0003729]; RNA 7-methylguanosine cap binding [GO:0000340]; RNA cap binding [GO:0000339]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000339; GO:0000340; GO:0003729; GO:0005634; GO:0005737
GN003972	GN003972.1	Q9D787	58.6	485	499	521	1.30e-191	547	PPIL2_MOUSE	RING-type E3 ubiquitin-protein ligase PPIL2 (EC 2.3.2.27) (CYC4) (Probable inactive peptidyl-prolyl cis-trans isomerase-like 2) (PPIase)	Mus musculus (Mouse)	protein folding [GO:0006457]; protein localization to plasma membrane [GO:0072659]; protein polyubiquitination [GO:0000209]	peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spliceosomal complex [GO:0005681]; U12-type catalytic step 2 spliceosome [GO:0071018]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0000209; GO:0003755; GO:0004842; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0005886; GO:0006457; GO:0034450; GO:0061630; GO:0071006; GO:0071013; GO:0071018; GO:0072659
GN003973	GN003973.1	Q4KLN4	42.6	324	796	698	2.19e-72	253	GLE1_RAT	mRNA export factor GLE1 (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1)	Rattus norvegicus (Rat)	poly(A)+ mRNA export from nucleus [GO:0016973]	identical protein binding [GO:0042802]; inositol hexakisphosphate binding [GO:0000822]; phospholipid binding [GO:0005543]; translation initiation factor binding [GO:0031369]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore cytoplasmic filaments [GO:0044614]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0000822; GO:0005543; GO:0005634; GO:0005635; GO:0005730; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0016973; GO:0031369; GO:0031965; GO:0036064; GO:0042802; GO:0044614
GN003975	GN003975.1	P43024	36.3	124	135	111	5.14e-14	66.6	CX6A1_MOUSE	Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver)	Mus musculus (Mouse)	mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	enzyme regulator activity [GO:0030234]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; respiratory chain complex IV [GO:0045277]; sperm principal piece [GO:0097228]	GO:0005739; GO:0005743; GO:0006123; GO:0030234; GO:0031966; GO:0043209; GO:0045277; GO:0097228
GN003978	GN003978.1	A0A8B8EY61	30.6	575	598	632	8.79e-77	259	CGLR2_CRAVI	Cyclic GMP-AMP synthase-like receptor 2 (Cv-cGLR2) (EC 2.7.7.-)	Crassostrea virginica (Eastern oyster)				
GN003979	GN003979.1	Q30TG0	44.6	213	220	266	1.78e-53	175	ISPE_SULDN	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (EC 2.7.1.148) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase)	Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; terpenoid biosynthetic process [GO:0016114]	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity [GO:0050515]; ATP binding [GO:0005524]		GO:0005524; GO:0016114; GO:0019288; GO:0050515
GN003980	GN003980.1	Q96LW2	42.7	293	396	410	9.99e-76	243	KS6R_HUMAN	Ribosomal protein S6 kinase-related protein (EC 2.7.11.1) (Sugen kinase 494)	Homo sapiens (Human)		ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]		GO:0004672; GO:0004674; GO:0005524; GO:0106310
GN003986	GN003986.1	O45782	24.3	341	378	426	2.44e-21	98.2	ARD17_CAEEL	Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1)	Caenorhabditis elegans		molecular adaptor activity [GO:0060090]; protein phosphatase 2B binding [GO:0030346]	cytoplasm [GO:0005737]	GO:0005737; GO:0030346; GO:0060090
GN003996	GN003996.1	P08953	22.0	576	796	1097	7.79e-13	76.3	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN004001	GN004001.1	Q9JLY0	71.3	167	387	533	3.08e-76	248	SOCS6_MOUSE	Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; negative regulation of T cell activation [GO:0050868]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; regulation of growth [GO:0040008]	signaling adaptor activity [GO:0035591]	cytosol [GO:0005829]; immunological synapse [GO:0001772]	GO:0001772; GO:0005829; GO:0010498; GO:0016567; GO:0035556; GO:0035591; GO:0040008; GO:0050868
GN004002	GN004002.1	P53568	59.0	83	124	150	3.00e-21	85.9	CEBPG_MOUSE	CCAAT/enhancer-binding protein gamma (C/EBP gamma) (Granulocyte colony-stimulating factor promoter element 1-binding protein) (GPE1-BP) (GPE1-binding protein) (Immunoglobulin enhancer-binding protein 1) (IG/EBP-1)	Mus musculus (Mouse)	B cell differentiation [GO:0030183]; chromatin remodeling [GO:0006338]; DNA-templated transcription [GO:0006351]; enucleate erythrocyte differentiation [GO:0043353]; immune response [GO:0006955]; liver development [GO:0001889]; mRNA metabolic process [GO:0016071]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome disassembly [GO:0006337]; positive regulation of DNA repair [GO:0045739]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; double-stranded DNA binding [GO:0003690]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending [GO:0044377]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000978; GO:0000981; GO:0001228; GO:0001889; GO:0003677; GO:0003690; GO:0003714; GO:0005634; GO:0005654; GO:0006337; GO:0006338; GO:0006351; GO:0006357; GO:0006955; GO:0016071; GO:0030183; GO:0032729; GO:0042267; GO:0043353; GO:0043565; GO:0044377; GO:0044877; GO:0045739; GO:0045944; GO:0090575; GO:0140297; GO:1990837
GN004003	GN004003.1	Q00322	49.5	99	315	268	2.53e-12	69.3	CEBPD_MOUSE	CCAAT/enhancer-binding protein delta (C/EBP delta) (C/EBP-related protein 3)	Mus musculus (Mouse)	DNA-templated transcription [GO:0006351]; fat cell differentiation [GO:0045444]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear development [GO:0048839]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000976; GO:0000978; GO:0000981; GO:0001228; GO:0002244; GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0006357; GO:0042802; GO:0043565; GO:0045444; GO:0045595; GO:0045669; GO:0045892; GO:0045944; GO:0048839; GO:0090575; GO:1990837
GN004008	GN004008.1	Q7YRA3	61.2	165	168	245	2.84e-67	207	EXOS4_BOVIN	Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41)	Bos taurus (Bovine)	DNA deamination [GO:0045006]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; nuclear mRNA surveillance [GO:0071028]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; rRNA catabolic process [GO:0016075]; U4 snRNA 3'-end processing [GO:0034475]	mRNA 3'-UTR AU-rich region binding [GO:0035925]; RNA binding [GO:0003723]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0000176; GO:0000177; GO:0000178; GO:0000460; GO:0000791; GO:0003723; GO:0005654; GO:0005730; GO:0005829; GO:0016075; GO:0030307; GO:0034475; GO:0035925; GO:0045006; GO:0071028; GO:0071044; GO:0071051
GN004009	GN004009.1	O35643	74.5	953	932	943	0.0	1346	AP1B1_MOUSE	AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)	Mus musculus (Mouse)	basolateral protein secretion [GO:0110010]; clathrin coat assembly [GO:0048268]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; receptor-mediated endocytosis [GO:0006898]; vesicle-mediated transport [GO:0016192]	clathrin binding [GO:0030276]; protein kinase binding [GO:0019901]; protein serine/threonine kinase binding [GO:0120283]	AP-1 adaptor complex [GO:0030121]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	GO:0001822; GO:0005765; GO:0005769; GO:0005794; GO:0005802; GO:0005829; GO:0006886; GO:0006898; GO:0007368; GO:0007507; GO:0008021; GO:0016192; GO:0019901; GO:0030121; GO:0030276; GO:0032588; GO:0048268; GO:0060155; GO:0110010; GO:0120283; GO:1903232
GN004010	GN004010.1	O00623	49.0	359	380	359	1.15e-111	333	PEX12_HUMAN	Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor 3) (PAF-3)	Homo sapiens (Human)	cellular response to reactive oxygen species [GO:0034614]; peroxisome organization [GO:0007031]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein targeting to peroxisome [GO:0006625]	transmembrane protein transporter activity [GO:0008320]; ubiquitin ligase activator activity [GO:1990757]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000209; GO:0005777; GO:0005778; GO:0005829; GO:0006515; GO:0006625; GO:0007031; GO:0008270; GO:0008320; GO:0016558; GO:0016562; GO:0034614; GO:0043161; GO:0044721; GO:1990429; GO:1990757
GN004011	GN004011.1	P63009	52.4	82	83	937	3.86e-17	77.4	AP2B1_BOVIN	AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)	Bos taurus (Bovine)	intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	clathrin binding [GO:0030276]	clathrin adaptor complex [GO:0030131]; cytoplasmic vesicle [GO:0031410]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]	GO:0005886; GO:0006886; GO:0012505; GO:0016192; GO:0030131; GO:0030276; GO:0031410
GN004012	GN004012.1	O35643	76.6	316	333	943	3.15e-147	441	AP1B1_MOUSE	AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)	Mus musculus (Mouse)	basolateral protein secretion [GO:0110010]; clathrin coat assembly [GO:0048268]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; receptor-mediated endocytosis [GO:0006898]; vesicle-mediated transport [GO:0016192]	clathrin binding [GO:0030276]; protein kinase binding [GO:0019901]; protein serine/threonine kinase binding [GO:0120283]	AP-1 adaptor complex [GO:0030121]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	GO:0001822; GO:0005765; GO:0005769; GO:0005794; GO:0005802; GO:0005829; GO:0006886; GO:0006898; GO:0007368; GO:0007507; GO:0008021; GO:0016192; GO:0019901; GO:0030121; GO:0030276; GO:0032588; GO:0048268; GO:0060155; GO:0110010; GO:0120283; GO:1903232
GN004013	GN004013.1	O35643	81.0	279	279	943	1.24e-149	445	AP1B1_MOUSE	AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)	Mus musculus (Mouse)	basolateral protein secretion [GO:0110010]; clathrin coat assembly [GO:0048268]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; receptor-mediated endocytosis [GO:0006898]; vesicle-mediated transport [GO:0016192]	clathrin binding [GO:0030276]; protein kinase binding [GO:0019901]; protein serine/threonine kinase binding [GO:0120283]	AP-1 adaptor complex [GO:0030121]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	GO:0001822; GO:0005765; GO:0005769; GO:0005794; GO:0005802; GO:0005829; GO:0006886; GO:0006898; GO:0007368; GO:0007507; GO:0008021; GO:0016192; GO:0019901; GO:0030121; GO:0030276; GO:0032588; GO:0048268; GO:0060155; GO:0110010; GO:0120283; GO:1903232
GN004035	GN004035.1	P24507	31.1	286	405	537	5.88e-34	135	SY63_DIPOM	Synaptotagmin-C (Synaptic vesicle protein O-p65-C)	Diplobatis ommata (Ocellated electric ray) (Discopyge ommata)	calcium-ion regulated exocytosis [GO:0017156]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]	plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	GO:0000149; GO:0001786; GO:0005509; GO:0005544; GO:0005886; GO:0017156; GO:0030276; GO:0030672
GN004041	GN004041.1	Q02225	52.7	313	300	717	3.42e-90	286	SKI_XENLA	Ski oncogene (Proto-oncogene c-Ski)	Xenopus laevis (African clawed frog)	negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; SMAD binding [GO:0046332]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000978; GO:0000981; GO:0005634; GO:0005667; GO:0005737; GO:0030512; GO:0030514; GO:0046332
GN004043	GN004043.1	O60242	33.6	122	1214	1522	5.48e-11	71.2	AGRB3_HUMAN	Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3)	Homo sapiens (Human)	cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; myoblast fusion [GO:0007520]; negative regulation of angiogenesis [GO:0016525]; neuron remodeling [GO:0016322]; regulation of dendrite morphogenesis [GO:0048814]; regulation of synapse maturation [GO:0090128]; regulation of synapse pruning [GO:1905806]	G protein-coupled receptor activity [GO:0004930]; GTPase activator activity [GO:0005096]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density membrane [GO:0098839]; synaptic cleft [GO:0043083]	GO:0004930; GO:0005096; GO:0005886; GO:0007166; GO:0007186; GO:0007520; GO:0016020; GO:0016322; GO:0016525; GO:0043083; GO:0048814; GO:0090128; GO:0098794; GO:0098839; GO:0150053; GO:1905806
GN004045	GN004045.1	Q9GP32	72.8	360	363	363	2.58e-187	525	ALF_ECHMU	Fructose-bisphosphate aldolase (EC 4.1.2.13)	Echinococcus multilocularis (Fox tapeworm)	glycolytic process [GO:0006096]	fructose-bisphosphate aldolase activity [GO:0004332]		GO:0004332; GO:0006096
GN004046	GN004046.1	Q99L20	34.7	147	158	241	1.42e-16	77.0	GSTT3_MOUSE	Glutathione S-transferase theta-3 (EC 2.5.1.18)	Mus musculus (Mouse)	glutathione metabolic process [GO:0006749]	glutathione transferase activity [GO:0004364]	cytoplasm [GO:0005737]	GO:0004364; GO:0005737; GO:0006749
GN004048	GN004048.1	A2BGR3	37.9	116	227	1451	1.04e-11	67.4	ERC6L_DANRE	DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like)	Danio rerio (Zebrafish) (Brachydanio rerio)	intein-mediated protein splicing [GO:0016539]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]	GO:0000775; GO:0003678; GO:0005524; GO:0005694; GO:0015616; GO:0016539; GO:0016887
GN004050	GN004050.1	Q8VCM5	32.9	295	296	352	2.32e-41	149	MUL1_MOUSE	Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 2.3.2.27) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Protein Hades) (RING-type E3 ubiquitin transferase NFKB 1)	Mus musculus (Mouse)	cellular response to exogenous dsRNA [GO:0071360]; mitochondrial fission [GO:0000266]; mitochondrion localization [GO:0051646]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of defense response to virus by host [GO:0050689]; negative regulation of innate immune response [GO:0045824]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; positive regulation of dendrite extension [GO:1903861]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of type 2 mitophagy [GO:1905091]; protein destabilization [GO:0031648]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901028]; regulation of mitochondrion organization [GO:0010821]; regulation of protein stability [GO:0031647]	identical protein binding [GO:0042802]; p53 binding [GO:0002039]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]	axon [GO:0030424]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; peroxisome [GO:0005777]; TOM complex [GO:0140596]	GO:0000209; GO:0000266; GO:0002039; GO:0005739; GO:0005741; GO:0005777; GO:0010637; GO:0010821; GO:0016567; GO:0016925; GO:0019789; GO:0030424; GO:0031625; GO:0031647; GO:0031648; GO:0033235; GO:0042802; GO:0043025; GO:0043123; GO:0045824; GO:0050689; GO:0050821; GO:0051646; GO:0051881; GO:0051898; GO:0060339; GO:0061630; GO:0070534; GO:0071360; GO:0071650; GO:0090141; GO:0140596; GO:0141111; GO:1901028; GO:1903861; GO:1905091
GN004064	GN004064.1	Q0E908	30.3	804	915	818	9.59e-91	309	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN004065	GN004065.1	Q0E908	30.9	793	841	818	5.90e-96	321	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN004066	GN004066.1	B2GV54	30.2	424	419	408	1.56e-51	181	NCEH1_RAT	Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1)	Rattus norvegicus (Rat)	ether lipid metabolic process [GO:0046485]; protein dephosphorylation [GO:0006470]; xenobiotic metabolic process [GO:0006805]	acetylalkylglycerol acetylhydrolase activity [GO:0047378]; phosphate ion binding [GO:0042301]; serine hydrolase activity [GO:0017171]; sterol ester esterase activity [GO:0004771]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004771; GO:0005886; GO:0006470; GO:0006805; GO:0016020; GO:0017171; GO:0042301; GO:0046485; GO:0047378
GN004067	GN004067.1	Q4RJN5	84.7	275	278	410	1.47e-57	192	LIS1_TETNG	Lissencephaly-1 homolog	Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)	brain morphogenesis [GO:0048854]; establishment of mitotic spindle orientation [GO:0000132]; microtubule sliding [GO:0051012]; reelin-mediated signaling pathway [GO:0038026]	dynein complex binding [GO:0070840]; protein heterodimerization activity [GO:0046982]	1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule associated complex [GO:0005875]	GO:0000132; GO:0005737; GO:0005813; GO:0005875; GO:0008247; GO:0038026; GO:0046982; GO:0048854; GO:0051012; GO:0070840
GN004068	GN004068.1	Q6DC64	46.2	383	646	471	2.64e-105	330	MET16_DANRE	RNA N(6)-adenosine-methyltransferase mettl16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346)	Danio rerio (Zebrafish) (Brachydanio rerio)	mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of mRNA splicing, via spliceosome [GO:0048024]; rRNA base methylation [GO:0070475]; S-adenosylmethionine biosynthetic process [GO:0006556]; snRNA (adenine-N6)-methylation [GO:0120049]	23S rRNA (adenine(1618)-N(6))-methyltransferase activity [GO:0052907]; mRNA m(6)A methyltransferase activity [GO:0001734]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; U6 snRNA (adenine(43)-N6)-methyltransferase activity [GO:0120048]; U6 snRNA 3'-end binding [GO:0030629]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001734; GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0006402; GO:0006556; GO:0010608; GO:0030629; GO:0035613; GO:0048024; GO:0052907; GO:0061157; GO:0070475; GO:0120048; GO:0120049
GN004072	GN004072.1	Q6DRD9	45.0	271	292	317	2.21e-75	236	ABHDB_DANRE	sn-1-specific diacylglycerol lipase ABHD11 (EC 3.1.1.116) (Alpha/beta hydrolase domain-containing protein 11) (Abhydrolase domain-containing protein 11) (Williams-Beuren syndrome chromosomal region 21 protein homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	lipid metabolic process [GO:0006629]	carboxylic ester hydrolase activity [GO:0052689]; lipase activity [GO:0016298]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252]	GO:0005739; GO:0005759; GO:0006629; GO:0016298; GO:0045252; GO:0052689
GN004073	GN004073.1	Q15286	72.7	172	192	201	2.72e-76	230	RAB35_HUMAN	Ras-related protein Rab-35 (EC 3.6.5.2) (GTP-binding protein RAY) (Ras-related protein Rab-1C)	Homo sapiens (Human)	antigen processing and presentation [GO:0019882]; cellular response to nerve growth factor stimulus [GO:1990090]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; intracellular protein localization [GO:0008104]; mitotic cytokinesis [GO:0000281]; neuron projection development [GO:0031175]; plasma membrane to endosome transport [GO:0048227]; protein localization to endosome [GO:0036010]; Rab protein signal transduction [GO:0032482]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cell projection membrane [GO:0031253]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	GO:0000281; GO:0003924; GO:0003925; GO:0005525; GO:0005546; GO:0005768; GO:0005829; GO:0005886; GO:0005905; GO:0008104; GO:0010008; GO:0016197; GO:0019003; GO:0019882; GO:0030669; GO:0031175; GO:0031253; GO:0032456; GO:0032482; GO:0036010; GO:0042470; GO:0045171; GO:0045334; GO:0048227; GO:0055038; GO:0070062; GO:1990090
GN004075	GN004075.1	P0CF95	38.5	122	630	569	3.76e-11	69.7	BICL1_DANRE	BICD family-like cargo adapter 1 (Bicaudal D-related protein 1) (BICD-related protein 1) (BICDR-1) (Coiled-coil domain-containing protein 64A)	Danio rerio (Zebrafish) (Brachydanio rerio)	brain development [GO:0007420]; embryonic camera-type eye development [GO:0031076]; eye development [GO:0001654]; Golgi to secretory granule transport [GO:0055107]; negative regulation of neuron projection development [GO:0010977]; neuron projection development [GO:0031175]; vesicle transport along microtubule [GO:0047496]	dynactin binding [GO:0034452]; small GTPase binding [GO:0031267]	centrosome [GO:0005813]	GO:0001654; GO:0005813; GO:0007420; GO:0010977; GO:0031076; GO:0031175; GO:0031267; GO:0034452; GO:0047496; GO:0055107
GN004077	GN004077.1	A5D8V6	34.9	109	209	355	6.76e-13	69.7	VP37C_HUMAN	Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C)	Homo sapiens (Human)	macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; protein targeting to membrane [GO:0006612]; protein targeting to vacuole [GO:0006623]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]	calcium-dependent protein binding [GO:0048306]	endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; nucleoplasm [GO:0005654]	GO:0000813; GO:0005654; GO:0006612; GO:0006623; GO:0010008; GO:0016236; GO:0031902; GO:0036258; GO:0039702; GO:0043162; GO:0043328; GO:0048306; GO:0070062; GO:0090148
GN004079	GN004079.1	F1RFX9	62.5	120	146	333	2.88e-40	140	M2OM_PIG	Mitochondrial 2-oxoglutarate/malate carrier protein (Alpha-oxoglutarate carrier) (OGCP) (Solute carrier family 25 member 11) (SLC25A11)	Sus scrofa (Pig)		alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; proton transmembrane transporter activity [GO:0015078]	mitochondrial inner membrane [GO:0005743]	GO:0005743; GO:0015078; GO:0015139
GN004080	GN004080.1	Q9ULI1	21.8	1436	1696	1742	4.35e-69	261	NWD2_HUMAN	NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239)	Homo sapiens (Human)			synapse [GO:0045202]	GO:0045202
GN004082	GN004082.1	P40926	63.5	277	280	338	2.90e-123	358	MDHM_HUMAN	Malate dehydrogenase, mitochondrial (EC 1.1.1.37)	Homo sapiens (Human)	aerobic respiration [GO:0009060]; gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]; malate-aspartate shuttle [GO:0043490]; tricarboxylic acid cycle [GO:0006099]	identical protein binding [GO:0042802]; L-malate dehydrogenase (NAD+) activity [GO:0030060]; L-malate dehydrogenase (NADP+) activity [GO:0046554]; RNA binding [GO:0003723]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005739; GO:0005759; GO:0006094; GO:0006099; GO:0006108; GO:0009060; GO:0016020; GO:0030060; GO:0042802; GO:0043490; GO:0046554; GO:0070062
GN004083	GN004083.1	Q9Y6J8	46.7	195	201	313	7.34e-58	187	STYL1_HUMAN	Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity phosphatase inhibitor MK-STYX) (Dual specificity protein phosphatase 24) (Inactive dual specificity protein phosphatase MK-STYX) (Map kinase phosphatase-like protein MK-STYX)	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]; negative regulation of stress granule assembly [GO:0062030]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron projection development [GO:0010976]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]	phosphatase inhibitor activity [GO:0019212]; protein phosphatase binding [GO:0019903]; pseudophosphatase activity [GO:0001691]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0001691; GO:0005739; GO:0005759; GO:0010976; GO:0019212; GO:0019903; GO:0035556; GO:0062030; GO:2001242; GO:2001244
GN004084	GN004084.1	Q9Y4P3	52.0	373	455	447	9.45e-134	395	TBL2_HUMAN	Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein)	Homo sapiens (Human)	cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; endoplasmic reticulum unfolded protein response [GO:0030968]	phosphoprotein binding [GO:0051219]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; translation initiation factor binding [GO:0031369]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0003723; GO:0005783; GO:0005789; GO:0005829; GO:0019901; GO:0030968; GO:0031369; GO:0042149; GO:0051219; GO:0071456
GN004085	GN004085.1	Q8VIP2	64.6	198	416	865	7.27e-72	244	MLXPL_RAT	Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein)	Rattus norvegicus (Rat)	cellular response to glucose stimulus [GO:0071333]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; glucose mediated signaling pathway [GO:0010255]; lipid biosynthetic process [GO:0008610]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glycolytic process [GO:0045821]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of glycolytic process [GO:0006110]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]; response to nutrient [GO:0007584]; response to nutrient levels [GO:0031667]; response to vitamin B3 [GO:0033552]	carbohydrate response element binding [GO:0035538]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000432; GO:0000785; GO:0000978; GO:0000981; GO:0001216; GO:0001227; GO:0001228; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005829; GO:0006110; GO:0006357; GO:0007584; GO:0008284; GO:0008610; GO:0009749; GO:0010255; GO:0019901; GO:0031667; GO:0033552; GO:0035538; GO:0035774; GO:0042593; GO:0043565; GO:0045723; GO:0045821; GO:0045892; GO:0045893; GO:0045944; GO:0046889; GO:0046982; GO:0055089; GO:0061629; GO:0071333; GO:0090324; GO:0097009; GO:0140297; GO:1901797
GN004086	GN004086.1	O75976	41.7	1281	1375	1380	1.72e-317	933	CBPD_HUMAN	Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)	Homo sapiens (Human)	peptide metabolic process [GO:0006518]; protein processing [GO:0016485]	metallocarboxypeptidase activity [GO:0004181]; serine-type carboxypeptidase activity [GO:0004185]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004181; GO:0004185; GO:0005886; GO:0006518; GO:0008270; GO:0016020; GO:0016485; GO:0070062
GN004087	GN004087.1	Q14DG7	25.0	979	1073	1078	8.17e-67	248	T132B_HUMAN	Transmembrane protein 132B	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN004088	GN004088.1	A2VDD2	35.8	123	231	176	1.07e-21	91.3	DYL5B_XENLA	Dynein light chain Tctex-type 5-B (Tctex1 domain-containing protein 1-B)	Xenopus laevis (African clawed frog)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505
GN004089	GN004089.1	Q7ZYR8	48.0	152	514	350	1.41e-29	122	RSRC2_XENLA	Arginine/serine-rich coiled-coil protein 2	Xenopus laevis (African clawed frog)				
GN004091	GN004091.1	Q6AYY8	61.3	483	521	550	1.54e-215	610	ACATN_RAT	Acetyl-coenzyme A transporter 1 (AT-1) (Acetyl-CoA transporter 1) (Solute carrier family 33 member 1)	Rattus norvegicus (Rat)	acetyl-CoA transmembrane transport [GO:0035348]	acetyl-CoA transmembrane transporter activity [GO:0008521]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0008521; GO:0035348; GO:0042803
GN004096	GN004096.1	Q8MSU3	30.9	162	232	647	8.07e-11	64.7	FRRS1_DROME	Ferric reductase 1 (EC 1.-.-.-) (stromal cell-derived receptor 2)	Drosophila melanogaster (Fruit fly)	intracellular iron ion homeostasis [GO:0006879]	oxidoreductase activity, acting on metal ions [GO:0016722]; transmembrane ascorbate ferrireductase activity [GO:0140571]	membrane [GO:0016020]	GO:0006879; GO:0016020; GO:0016722; GO:0140571
GN004097	GN004097.1	P31637	58.9	548	699	718	1.29e-224	647	SC5A3_CANLF	Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3)	Canis lupus familiaris (Dog) (Canis familiaris)	D-glucose transmembrane transport [GO:1904659]; fucose transmembrane transport [GO:0015756]; myo-inositol transport [GO:0015798]; pentose transmembrane transport [GO:0015750]; polyol transmembrane transport [GO:0015791]	D-glucose:sodium symporter activity [GO:0005412]; fucose transmembrane transporter activity [GO:0015150]; myo-inositol:sodium symporter activity [GO:0005367]; pentose transmembrane transporter activity [GO:0015146]; polyol transmembrane transporter activity [GO:0015166]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	GO:0005367; GO:0005412; GO:0005886; GO:0008076; GO:0015146; GO:0015150; GO:0015166; GO:0015750; GO:0015756; GO:0015791; GO:0015798; GO:0016323; GO:0016324; GO:1904659
GN004098	GN004098.1	B1AJZ9	25.1	1469	1377	1412	3.59e-72	269	FHAD1_HUMAN	Forkhead-associated domain-containing protein 1 (FHA domain-containing protein 1)	Homo sapiens (Human)			sperm flagellum [GO:0036126]	GO:0036126
GN004099	GN004099.1	P17809	44.9	459	492	492	1.20e-128	385	GTR1_MOUSE	Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (GT1)	Mus musculus (Mouse)	cellular hyperosmotic response [GO:0071474]; cellular response to glucose starvation [GO:0042149]; cellular response to mechanical stimulus [GO:0071260]; central nervous system development [GO:0007417]; cerebral cortex development [GO:0021987]; D-glucose import across plasma membrane [GO:0098708]; D-glucose transmembrane transport [GO:1904659]; dehydroascorbic acid transport [GO:0070837]; female pregnancy [GO:0007565]; long-chain fatty acid import across plasma membrane [GO:0015911]; photoreceptor cell maintenance [GO:0045494]; protein-containing complex assembly [GO:0065003]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to Thyroglobulin triiodothyronine [GO:1904016]; transport across blood-brain barrier [GO:0150104]; xenobiotic transport [GO:0042908]	D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; fucose transmembrane transporter activity [GO:0015150]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; female pronucleus [GO:0001939]; glucose transporter complex [GO:1990350]; Golgi membrane [GO:0000139]; intercalated disc [GO:0014704]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; midbody [GO:0030496]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; sarcolemma [GO:0042383]; synapse [GO:0045202]; vesicle [GO:0031982]; Z disc [GO:0030018]	GO:0000139; GO:0001666; GO:0001917; GO:0001939; GO:0005324; GO:0005737; GO:0005829; GO:0005886; GO:0005901; GO:0005911; GO:0007417; GO:0007565; GO:0014704; GO:0015150; GO:0015911; GO:0016020; GO:0016323; GO:0016324; GO:0019900; GO:0021987; GO:0030018; GO:0030496; GO:0030864; GO:0031982; GO:0032868; GO:0033300; GO:0042149; GO:0042383; GO:0042470; GO:0042802; GO:0042908; GO:0042910; GO:0045121; GO:0045202; GO:0045494; GO:0055056; GO:0065003; GO:0070837; GO:0071260; GO:0071474; GO:0098708; GO:0098793; GO:0150104; GO:1904016; GO:1904659; GO:1990350
GN004100	GN004100.1	P42674	42.0	150	308	597	5.65e-35	136	BP10_PARLI	Blastula protease 10 (EC 3.4.24.-)	Paracentrotus lividus (Common sea urchin)	molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]	GO:0004222; GO:0005576; GO:0005938; GO:0006508; GO:0008270; GO:0018996; GO:0048471
GN004103	GN004103.1	P47756	83.6	269	273	272	4.47e-166	463	CAPZB_HUMAN	F-actin-capping protein subunit beta (CapZ beta)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]	actin binding [GO:0003779]; cadherin binding [GO:0045296]	actin cytoskeleton [GO:0015629]; brush border [GO:0005903]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; sarcomere [GO:0030017]; Schaffer collateral - CA1 synapse [GO:0098685]; sperm head-tail coupling apparatus [GO:0120212]; WASH complex [GO:0071203]	GO:0003779; GO:0005829; GO:0005856; GO:0005903; GO:0008290; GO:0014069; GO:0015629; GO:0016020; GO:0030017; GO:0030027; GO:0030036; GO:0030863; GO:0045296; GO:0051016; GO:0070062; GO:0071203; GO:0098685; GO:0098686; GO:0120212
GN004104	GN004104.1	A1Z9X0	68.2	594	599	606	7.48e-303	837	APKC_DROME	Atypical protein kinase C (EC 2.7.11.13)	Drosophila melanogaster (Fruit fly)	adherens junction organization [GO:0034332]; apical protein localization [GO:0045176]; asymmetric neuroblast division [GO:0055059]; asymmetric protein localization involved in cell fate determination [GO:0045167]; branching involved in open tracheal system development [GO:0060446]; cell-cell junction assembly [GO:0007043]; compound eye retinal cell programmed cell death [GO:0046667]; epithelial cell morphogenesis [GO:0003382]; establishment of cell polarity [GO:0030010]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of epithelial cell planar polarity [GO:0090163]; establishment of mitotic spindle orientation [GO:0000132]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of neuroblast polarity [GO:0045196]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; establishment or maintenance of polarity of follicular epithelium [GO:0016334]; exocyst localization [GO:0051601]; germarium-derived oocyte fate determination [GO:0007294]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; melanotic encapsulation of foreign target [GO:0035011]; memory [GO:0007613]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of hippo signaling [GO:0035331]; nuclear envelope budding [GO:0140591]; oocyte anterior/posterior axis specification [GO:0007314]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to plasma membrane [GO:0072659]; regulation of intracellular mRNA localization [GO:1904580]; regulation of polarized epithelial cell differentiation [GO:0030860]; sensory organ development [GO:0007423]; spermatogenesis [GO:0007283]; synapse assembly [GO:0007416]; terminal branching, open tracheal system [GO:0007430]; zonula adherens assembly [GO:0045186]	ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; myosin binding [GO:0017022]; PDZ domain binding [GO:0030165]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	apical cortex [GO:0045179]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; cell cortex [GO:0005938]; PAR polarity complex [GO:0120157]; subapical complex [GO:0035003]	GO:0000132; GO:0001738; GO:0002052; GO:0003382; GO:0004674; GO:0004697; GO:0005524; GO:0005938; GO:0007043; GO:0007163; GO:0007283; GO:0007294; GO:0007314; GO:0007416; GO:0007423; GO:0007430; GO:0007613; GO:0010592; GO:0016324; GO:0016327; GO:0016332; GO:0016334; GO:0017022; GO:0030010; GO:0030011; GO:0030165; GO:0030860; GO:0034332; GO:0035003; GO:0035011; GO:0035331; GO:0035556; GO:0043296; GO:0045167; GO:0045176; GO:0045179; GO:0045186; GO:0045196; GO:0045197; GO:0045198; GO:0045880; GO:0046667; GO:0051491; GO:0051601; GO:0055059; GO:0060446; GO:0072659; GO:0090163; GO:0106310; GO:0120157; GO:0140591; GO:1904580
GN004107	GN004107.1	O43156	36.5	1096	1072	1089	1.11e-216	653	TTI1_HUMAN	TELO2-interacting protein 1 homolog (Protein SMG10)	Homo sapiens (Human)	positive regulation of DNA damage checkpoint [GO:2000003]; protein stabilization [GO:0050821]; regulation of TOR signaling [GO:0032006]	kinase binding [GO:0019900]; protein-containing complex stabilizing activity [GO:0140777]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]; TTT Hsp90 cochaperone complex [GO:0110078]	GO:0005634; GO:0005737; GO:0019900; GO:0031931; GO:0031932; GO:0032006; GO:0050821; GO:0110078; GO:0140777; GO:2000003
GN004108	GN004108.1	P52569	53.2	601	603	658	1.47e-211	607	CTR2_HUMAN	Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)	Homo sapiens (Human)	amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-lysine transmembrane transport [GO:1903401]; L-ornithine transmembrane transport [GO:1903352]; regulation of macrophage activation [GO:0043030]; transport across blood-brain barrier [GO:0150104]	amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]	cell junction [GO:0030054]; plasma membrane [GO:0005886]	GO:0000064; GO:0005886; GO:0006865; GO:0015171; GO:0015174; GO:0015179; GO:0015189; GO:0015807; GO:0030054; GO:0043030; GO:0061459; GO:0089718; GO:0097638; GO:0150104; GO:1902475; GO:1903352; GO:1903401; GO:1903826
GN004110	GN004110.1	Q6TL19	32.7	107	201	1100	1.56e-10	63.2	GUC2G_MOUSE	Guanylate cyclase 2G (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G)	Mus musculus (Mouse)	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0006182; GO:0007168; GO:0009897; GO:0016020; GO:0035556
GN004111	GN004111.1	O02654	80.2	318	322	434	5.35e-186	522	ENO_DORPE	Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)	Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)	glycolytic process [GO:0006096]	magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]	phosphopyruvate hydratase complex [GO:0000015]	GO:0000015; GO:0000287; GO:0004634; GO:0006096
GN004112	GN004112.1	Q8C811	54.4	309	361	405	7.74e-108	324	S35E2_MOUSE	Solute carrier family 35 member E2A	Mus musculus (Mouse)	blastocyst hatching [GO:0001835]		membrane [GO:0016020]	GO:0001835; GO:0016020
GN004114	GN004114.1	Q3SYU1	49.3	209	322	746	1.47e-58	203	NOC2L_BOVIN	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor)	Bos taurus (Bovine)	ribosomal large subunit biogenesis [GO:0042273]		Noc1p-Noc2p complex [GO:0030690]; Noc2p-Noc3p complex [GO:0030691]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005730; GO:0030690; GO:0030691; GO:0042273
GN004117	GN004117.1	Q6MG64	28.0	654	1026	892	1.26e-36	153	VWA7_RAT	von Willebrand factor A domain-containing protein 7 (Protein G7c)	Rattus norvegicus (Rat)			extracellular region [GO:0005576]	GO:0005576
GN004118	GN004118.1	Q58DH1	34.4	93	531	297	4.22e-13	73.6	XAF1_BOVIN	XIAP-associated factor 1	Bos taurus (Bovine)	apoptotic process [GO:0006915]		mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005739; GO:0006915
GN004119	GN004119.1	P48441	45.3	631	779	634	1.15e-189	557	IDUA_MOUSE	Alpha-L-iduronidase (EC 3.2.1.76)	Mus musculus (Mouse)	adult locomotory behavior [GO:0008344]; adult walking behavior [GO:0007628]; bone development [GO:0060348]; carbohydrate metabolic process [GO:0005975]; cartilage homeostasis [GO:1990079]; cell morphogenesis [GO:0000902]; chemical homeostasis [GO:0048878]; dermatan sulfate proteoglycan catabolic process [GO:0030209]; extracellular matrix organization [GO:0030198]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparin proteoglycan catabolic process [GO:0030211]; limb morphogenesis [GO:0035108]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; memory [GO:0007613]; negative regulation of cartilage development [GO:0061037]; negative regulation of secretion of lysosomal enzymes [GO:0090341]; positive regulation of bone resorption [GO:0045780]; positive regulation of collagen catabolic process [GO:0120158]; skeletal system morphogenesis [GO:0048705]; visual learning [GO:0008542]	L-iduronidase activity [GO:0003940]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	GO:0000902; GO:0003940; GO:0005102; GO:0005576; GO:0005764; GO:0005975; GO:0006027; GO:0007040; GO:0007613; GO:0007626; GO:0007628; GO:0008344; GO:0008542; GO:0030198; GO:0030200; GO:0030209; GO:0030211; GO:0035108; GO:0043202; GO:0045780; GO:0048705; GO:0048878; GO:0060348; GO:0061037; GO:0090341; GO:0120158; GO:1990079
GN004120	GN004120.1	P58058	59.0	327	334	439	5.17e-135	394	NADK_MOUSE	NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase)	Mus musculus (Mouse)	NAD+ metabolic process [GO:0019674]; NADP+ biosynthetic process [GO:0006741]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]	NAD+ kinase activity [GO:0003951]	cytosol [GO:0005829]	GO:0003951; GO:0005829; GO:0006741; GO:0019674; GO:0035774
GN004130	GN004130.1	P28572	43.6	55	91	638	5.09e-09	54.7	SC6A9_RAT	Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9)	Rattus norvegicus (Rat)	glycine import across plasma membrane [GO:1903804]; glycine secretion, neurotransmission [GO:0061537]; glycine transport [GO:0015816]; neurotransmitter uptake [GO:0001504]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; regulation of synaptic transmission, glycinergic [GO:0060092]; sodium ion transmembrane transport [GO:0035725]	amino acid:sodium symporter activity [GO:0005283]; glycine transmembrane transporter activity [GO:0015187]; glycine:sodium symporter activity [GO:0015375]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; dense core granule [GO:0031045]; endosome [GO:0005768]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lateral plasma membrane [GO:0016328]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]	GO:0001504; GO:0005283; GO:0005768; GO:0005886; GO:0009925; GO:0014069; GO:0015187; GO:0015375; GO:0015816; GO:0016323; GO:0016324; GO:0016328; GO:0030672; GO:0031045; GO:0035725; GO:0042734; GO:0045211; GO:0046985; GO:0060092; GO:0061537; GO:0070455; GO:0098686; GO:0098688; GO:1903804
GN004133	GN004133.1	Q05737	32.9	173	200	203	6.00e-27	104	YPTM2_MAIZE	GTP-binding protein YPTM2	Zea mays (Maize)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]	GO:0003924; GO:0005525; GO:0005886
GN004137	GN004137.1	P51893	74.1	263	266	433	7.56e-142	408	SAHHA_XENLA	Adenosylhomocysteinase A (AdoHcyase A) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase A)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN004138	GN004138.1	O93477	91.6	107	128	433	7.01e-64	203	SAHHB_XENLA	Adenosylhomocysteinase B (AdoHcyase B) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase B)	Xenopus laevis (African clawed frog)	L-methionine cycle [GO:0033353]	adenosylhomocysteinase activity [GO:0004013]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004013; GO:0005737; GO:0005829; GO:0033353; GO:0051287
GN004140	GN004140.1	Q8R2N2	36.5	694	672	686	8.53e-141	430	UTP4_MOUSE	U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (Testis-expressed gene 292 protein)	Mus musculus (Mouse)	maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of DNA-templated transcription [GO:0006355]; ribosomal small subunit biogenesis [GO:0042274]		90S preribosome [GO:0030686]; chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455]	GO:0000462; GO:0001650; GO:0005694; GO:0005730; GO:0006355; GO:0030490; GO:0030686; GO:0032040; GO:0034455; GO:0042274
GN004141	GN004141.1	Q10569	56.5	1401	1379	1444	0.0	1559	CPSF1_BOVIN	Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)	Bos taurus (Bovine)		nucleic acid binding [GO:0003676]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]	GO:0003676; GO:0005654; GO:0005847
GN004142	GN004142.1	Q99L04	49.1	330	327	313	1.22e-106	317	DHRS1_MOUSE	Dehydrogenase/reductase SDR family member 1 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 19C member 1) (Protein SDR19C1)	Mus musculus (Mouse)		carbonyl reductase (NADPH) activity [GO:0004090]; estradiol 17-alpha-dehydrogenase [NAD(P)+] activity [GO:0047881]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; testosterone dehydrogenase (NADP+) activity [GO:0047045]	endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0004090; GO:0005739; GO:0005743; GO:0005783; GO:0016616; GO:0047045; GO:0047881
GN004143	GN004143.1	A0A481NSZ4	30.0	476	480	473	4.10e-59	204	BPI_SEBSC	Bactericidal permeability-increasing protein (BPI) (Lipopolysaccharide-binding protein) (LBP)	Sebastes schlegelii (Korean rockfish)		lipid binding [GO:0008289]	extracellular region [GO:0005576]	GO:0005576; GO:0008289
GN004145	GN004145.1	Q91XU0	61.5	52	232	660	2.52e-16	80.9	WRIP1_MOUSE	ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1)	Mus musculus (Mouse)	DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; single-stranded DNA helicase activity [GO:0017116]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0000731; GO:0000781; GO:0003677; GO:0005524; GO:0005634; GO:0005737; GO:0006261; GO:0008047; GO:0016887; GO:0017116; GO:0030174; GO:0042802; GO:0048471
GN004146	GN004146.1	Q91XU0	57.4	366	348	660	8.35e-140	414	WRIP1_MOUSE	ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1)	Mus musculus (Mouse)	DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; single-stranded DNA helicase activity [GO:0017116]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0000731; GO:0000781; GO:0003677; GO:0005524; GO:0005634; GO:0005737; GO:0006261; GO:0008047; GO:0016887; GO:0017116; GO:0030174; GO:0042802; GO:0048471
GN004148	GN004148.1	A6NE52	25.3	730	1537	1622	2.14e-70	265	WDR97_HUMAN	WD repeat-containing protein 97	Homo sapiens (Human)				
GN004150	GN004150.1	Q5RDW1	53.2	342	382	406	1.46e-116	347	MTG2_PONAB	Mitochondrial ribosome-associated GTPase 2 (GTP-binding protein 5)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	mitochondrial large ribosomal subunit assembly [GO:1902775]; regulation of mitochondrial translation [GO:0070129]; regulation of respiratory system process [GO:0044065]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial ribosome [GO:0005761]	GO:0000287; GO:0003924; GO:0005525; GO:0005743; GO:0005759; GO:0005761; GO:0044065; GO:0070129; GO:1902775
GN004152	GN004152.1	Q5SVQ8	26.4	216	1320	909	8.95e-09	63.9	ZBT41_HUMAN	Zinc finger and BTB domain-containing protein 41	Homo sapiens (Human)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357
GN004153	GN004153.1	Q9U3V5	34.3	213	867	1024	5.78e-19	96.3	TIPT_DROME	Protein tiptop	Drosophila melanogaster (Fruit fly)	compound eye development [GO:0048749]; epidermis morphogenesis [GO:0048730]; Malpighian tubule stellate cell differentiation [GO:0061330]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of segmental identity, head [GO:0007380]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	nucleus [GO:0005634]	GO:0000122; GO:0000981; GO:0003677; GO:0005634; GO:0006357; GO:0007380; GO:0048730; GO:0048749; GO:0061330
GN004155	GN004155.1	O90760	29.4	170	552	341	7.35e-09	61.2	V031_FOWPN	Putative ankyrin repeat protein FPV031	Fowlpox virus (strain NVSL) (FPV)				
GN004156	GN004156.1	Q9WTK8	51.6	349	361	396	6.33e-128	375	SPO11_MOUSE	Meiotic recombination protein SPO11 (EC 5.6.2.2)	Mus musculus (Mouse)	double-strand break repair involved in meiotic recombination [GO:1990918]; homologous chromosome pairing at meiosis [GO:0007129]; male meiosis I [GO:0007141]; meiotic DNA double-strand break formation [GO:0042138]; meiotic DNA double-strand break processing [GO:0000706]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; ovarian follicle development [GO:0001541]; protein localization to chromosome [GO:0034502]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; synaptonemal complex assembly [GO:0007130]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]	GO:0000228; GO:0000706; GO:0000781; GO:0001541; GO:0003677; GO:0003918; GO:0004520; GO:0005524; GO:0005654; GO:0005694; GO:0007129; GO:0007130; GO:0007131; GO:0007141; GO:0007286; GO:0009330; GO:0034502; GO:0035861; GO:0042138; GO:0045141; GO:0048477; GO:1990918
GN004157	GN004157.1	Q5RGB8	32.2	599	599	605	2.43e-95	307	KLH26_DANRE	Kelch-like protein 26	Danio rerio (Zebrafish) (Brachydanio rerio)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]	GO:0031463; GO:0043161; GO:1990756
GN004158	GN004158.1	Q96A23	56.9	209	213	557	1.89e-74	237	CPNE4_HUMAN	Copine-4 (Copine IV) (Copine-8)	Homo sapiens (Human)	cellular response to calcium ion [GO:0071277]	calcium-dependent phospholipid binding [GO:0005544]	extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]	GO:0005544; GO:0070062; GO:0071277; GO:0098978
GN004159	GN004159.1	O75131	54.9	532	545	537	1.50e-201	575	CPNE3_HUMAN	Copine-3 (Copine III)	Homo sapiens (Human)	cellular response to calcium ion [GO:0071277]; cellular response to growth factor stimulus [GO:0071363]; ERBB2 signaling pathway [GO:0038128]; glycerophospholipid biosynthetic process [GO:0046474]; positive regulation of cell migration [GO:0030335]	calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; protein serine/threonine kinase activity [GO:0004674]; protein-membrane adaptor activity [GO:0043495]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]	anchoring junction [GO:0070161]; azurophil granule membrane [GO:0035577]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0003723; GO:0004674; GO:0005544; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0005925; GO:0030054; GO:0030335; GO:0030971; GO:0035577; GO:0038128; GO:0043495; GO:0046474; GO:0048306; GO:0070062; GO:0070161; GO:0071277; GO:0071363
GN004160	GN004160.1	Q08BG1	49.4	271	277	437	2.73e-92	282	TMPPE_DANRE	Transmembrane protein with metallophosphoesterase domain (EC 3.1.-.-)	Danio rerio (Zebrafish) (Brachydanio rerio)		hydrolase activity [GO:0016787]	membrane [GO:0016020]	GO:0016020; GO:0016787
GN004164	GN004164.1	Q14028	42.6	566	1277	1251	3.41e-141	464	CNGB1_HUMAN	Cyclic nucleotide-gated channel beta-1 (CNG channel beta-1) (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Glutamic acid-rich protein) (GARP)	Homo sapiens (Human)	calcium ion transport [GO:0006816]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; detection of light stimulus involved in visual perception [GO:0050908]; G protein-coupled receptor signaling pathway [GO:0007186]; membrane depolarization [GO:0051899]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; olfactory nerve maturation [GO:0021630]; potassium ion transport [GO:0006813]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to odorant [GO:1990834]; retina homeostasis [GO:0001895]; sensory perception of smell [GO:0007608]; sodium ion transport [GO:0006814]; visual perception [GO:0007601]	cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; protein-containing complex binding [GO:0044877]	ciliary membrane [GO:0060170]; Golgi-associated vesicle membrane [GO:0030660]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; non-motile cilium membrane [GO:0098804]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]; terminal bouton [GO:0043195]; transmembrane transporter complex [GO:1902495]	GO:0001750; GO:0001895; GO:0005222; GO:0005223; GO:0005886; GO:0006812; GO:0006813; GO:0006814; GO:0006816; GO:0007186; GO:0007601; GO:0007608; GO:0015276; GO:0017071; GO:0021630; GO:0030552; GO:0030553; GO:0030660; GO:0043195; GO:0044877; GO:0050908; GO:0050911; GO:0051480; GO:0051899; GO:0060170; GO:0098655; GO:0098804; GO:0120200; GO:1902495; GO:1990834
GN004177	GN004177.1	Q28F51	45.3	212	221	409	2.00e-34	129	TADBP_XENTR	TAR DNA-binding protein 43 (TDP-43)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of protein stability [GO:0031647]; RNA splicing [GO:0008380]	double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0003690; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0008380; GO:0010468; GO:0010494; GO:0031647; GO:0042752
GN004178	GN004178.1	P54363	57.0	93	96	181	2.89e-33	116	APT_DROPS	Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7)	Drosophila pseudoobscura pseudoobscura (Fruit fly)	adenine salvage [GO:0006168]; AMP salvage [GO:0044209]	adenine binding [GO:0002055]; adenine phosphoribosyltransferase activity [GO:0003999]; AMP binding [GO:0016208]	cytoplasm [GO:0005737]	GO:0002055; GO:0003999; GO:0005737; GO:0006168; GO:0016208; GO:0044209
GN004179	GN004179.1	P86786	68.9	225	733	284	1.53e-100	313	GIGA3_MAGGI	Gigasin-3a	Magallana gigas (Pacific oyster) (Crassostrea gigas)				
GN004182	GN004182.1	Q8C3P7	72.5	320	558	580	3.98e-180	523	MTA70_MOUSE	N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70)	Mus musculus (Mouse)	cellular response to UV [GO:0034644]; chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; dosage compensation by inactivation of X chromosome [GO:0009048]; endothelial to hematopoietic transition [GO:0098508]; forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; mRNA export from nucleus [GO:0006406]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; oogenesis [GO:0048477]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of translation [GO:0045727]; primary miRNA processing [GO:0031053]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of meiotic cell cycle [GO:0051445]; regulation of T cell differentiation [GO:0045580]; RNA methylation [GO:0001510]; RNA stabilization [GO:0043489]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827]	mRNA binding [GO:0003729]; mRNA m(6)A methyltransferase activity [GO:0001734]; protein heterodimerization activity [GO:0046982]; RNA methyltransferase activity [GO:0008173]; S-adenosyl-L-methionine binding [GO:1904047]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	GO:0000398; GO:0001510; GO:0001734; GO:0003729; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006397; GO:0006402; GO:0006406; GO:0006974; GO:0007283; GO:0007623; GO:0008173; GO:0009048; GO:0016556; GO:0016604; GO:0016607; GO:0019827; GO:0021861; GO:0031053; GO:0034644; GO:0036396; GO:0042063; GO:0043489; GO:0045580; GO:0045727; GO:0045746; GO:0046982; GO:0048477; GO:0051445; GO:0060339; GO:0061014; GO:0061157; GO:0098508; GO:0141119; GO:1902036; GO:1903679; GO:1904047
GN004185	GN004185.1	Q04164	25.9	321	1202	1693	2.16e-12	75.9	SAS_DROME	Putative epidermal cell surface receptor (Stranded at second protein)	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell signaling via exosome [GO:0099156]; instar larval development [GO:0002168]; positive regulation of cell differentiation [GO:0045597]	integrin binding [GO:0005178]; membrane-membrane adaptor activity [GO:0140177]; molecular adaptor activity [GO:0060090]; signaling receptor activity [GO:0038023]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	GO:0002168; GO:0005178; GO:0005886; GO:0007155; GO:0007411; GO:0016324; GO:0038023; GO:0045597; GO:0060090; GO:0070062; GO:0099156; GO:0140177
GN004188	GN004188.1	Q8BQM4	32.5	680	646	679	4.96e-80	270	HEAT3_MOUSE	HEAT repeat-containing protein 3 (Symportin Syo1)	Mus musculus (Mouse)	erythrocyte maturation [GO:0043249]; protein import into nucleus [GO:0006606]; ribosomal large subunit biogenesis [GO:0042273]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005829; GO:0006606; GO:0042273; GO:0043249
GN004189	GN004189.1	O15943	38.5	439	420	3097	4.75e-83	281	CADN_DROME	Neural-cadherin (Cadherin-N) (dN-cadherin)	Drosophila melanogaster (Fruit fly)	axon extension [GO:0048675]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; axonal fasciculation [GO:0007413]; calcium-dependent cell-cell adhesion [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell-cell adhesion [GO:0007156]; negative regulation of dendrite morphogenesis [GO:0050774]; ommatidial rotation [GO:0016318]; R7 cell development [GO:0045467]; R8 cell development [GO:0045463]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of dendrite morphogenesis [GO:0048814]; retinal ganglion cell axon guidance [GO:0031290]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005911; GO:0007156; GO:0007411; GO:0007412; GO:0007413; GO:0016020; GO:0016318; GO:0016339; GO:0030424; GO:0030425; GO:0031290; GO:0042803; GO:0044331; GO:0045296; GO:0045463; GO:0045467; GO:0048675; GO:0048814; GO:0048841; GO:0048846; GO:0050774; GO:0098609
GN004190	GN004190.1	Q9VJB6	54.4	57	81	1799	4.72e-14	68.6	CADN2_DROME	Putative neural-cadherin 2 (Cadherin-N2) (dN2-cadherin)	Drosophila melanogaster (Fruit fly)	axon extension involved in axon guidance [GO:0048846]; calcium-dependent cell-cell adhesion [GO:0016339]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell-cell adhesion [GO:0007156]; neuron projection development [GO:0031175]; ommatidial rotation [GO:0016318]; R7 cell development [GO:0045467]; R8 cell development [GO:0045463]	beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	catenin complex [GO:0016342]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0007156; GO:0008013; GO:0016318; GO:0016339; GO:0016342; GO:0016477; GO:0031175; GO:0044331; GO:0045296; GO:0045463; GO:0045467; GO:0048846; GO:0098609
GN004191	GN004191.1	O15943	37.6	901	929	3097	2.43e-141	469	CADN_DROME	Neural-cadherin (Cadherin-N) (dN-cadherin)	Drosophila melanogaster (Fruit fly)	axon extension [GO:0048675]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; axonal fasciculation [GO:0007413]; calcium-dependent cell-cell adhesion [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell-cell adhesion [GO:0007156]; negative regulation of dendrite morphogenesis [GO:0050774]; ommatidial rotation [GO:0016318]; R7 cell development [GO:0045467]; R8 cell development [GO:0045463]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of dendrite morphogenesis [GO:0048814]; retinal ganglion cell axon guidance [GO:0031290]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005911; GO:0007156; GO:0007411; GO:0007412; GO:0007413; GO:0016020; GO:0016318; GO:0016339; GO:0030424; GO:0030425; GO:0031290; GO:0042803; GO:0044331; GO:0045296; GO:0045463; GO:0045467; GO:0048675; GO:0048814; GO:0048841; GO:0048846; GO:0050774; GO:0098609
GN004192	GN004192.1	O15943	34.2	395	472	3097	2.17e-43	167	CADN_DROME	Neural-cadherin (Cadherin-N) (dN-cadherin)	Drosophila melanogaster (Fruit fly)	axon extension [GO:0048675]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; axonal fasciculation [GO:0007413]; calcium-dependent cell-cell adhesion [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell-cell adhesion [GO:0007156]; negative regulation of dendrite morphogenesis [GO:0050774]; ommatidial rotation [GO:0016318]; R7 cell development [GO:0045467]; R8 cell development [GO:0045463]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of dendrite morphogenesis [GO:0048814]; retinal ganglion cell axon guidance [GO:0031290]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005911; GO:0007156; GO:0007411; GO:0007412; GO:0007413; GO:0016020; GO:0016318; GO:0016339; GO:0030424; GO:0030425; GO:0031290; GO:0042803; GO:0044331; GO:0045296; GO:0045463; GO:0045467; GO:0048675; GO:0048814; GO:0048841; GO:0048846; GO:0050774; GO:0098609
GN004194	GN004194.1	E0W1I1	34.0	580	657	575	8.66e-87	285	PINK1_PEDHC	Serine/threonine-protein kinase Pink1, mitochondrial (EC 2.7.11.1) (PTEN-induced putative kinase 1)	Pediculus humanus subsp. corporis (Body louse)	autophagy of mitochondrion [GO:0000422]; positive regulation of mitochondrial fission [GO:0090141]; regulation of apoptotic process [GO:0042981]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]	GO:0000422; GO:0004672; GO:0004674; GO:0005524; GO:0005741; GO:0005743; GO:0005829; GO:0042981; GO:0090141; GO:0106310
GN004202	GN004202.1	Q9NQQ7	56.9	313	384	365	1.08e-114	341	S35H1_HUMAN	Solute carrier family 35 member H1 (Ovarian cancer-overexpressed gene 1 protein) (Solute carrier family 35 member C2)	Homo sapiens (Human)	UDP-glucose transmembrane transport [GO:0015786]		cis-Golgi network [GO:0005801]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]	GO:0005793; GO:0005794; GO:0005801; GO:0015786; GO:0033116
GN004206	GN004206.1	Q76I76	51.7	439	1331	1423	4.05e-123	419	SSH2_HUMAN	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; negative regulation of actin filament polymerization [GO:0030837]; protein dephosphorylation [GO:0006470]	actin binding [GO:0003779]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]	GO:0001669; GO:0003779; GO:0004721; GO:0004722; GO:0004725; GO:0005576; GO:0005737; GO:0005856; GO:0005925; GO:0006470; GO:0030036; GO:0030837
GN004207	GN004207.1	A4FU69	35.5	1304	1277	1503	7.16e-172	553	EFCB5_HUMAN	EF-hand calcium-binding domain-containing protein 5	Homo sapiens (Human)		calcium ion binding [GO:0005509]		GO:0005509
GN004208	GN004208.1	Q9ES34	73.1	186	186	1070	1.87e-95	301	UBE3B_MOUSE	Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B)	Mus musculus (Mouse)	protein polyubiquitination [GO:0000209]; regulation of postsynapse assembly [GO:0150052]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]	glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]	GO:0000209; GO:0005739; GO:0006511; GO:0014069; GO:0061630; GO:0098794; GO:0098978; GO:0150052
GN004210	GN004210.1	Q9VF27	76.2	185	210	217	1.12e-76	232	NDUS8_DROME	NADH dehydrogenase (ubiquinone) 23 kDa subunit (EC 7.1.1.2)	Drosophila melanogaster (Fruit fly)	mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]	4 iron, 4 sulfur cluster binding [GO:0051539]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271]	GO:0005739; GO:0005743; GO:0006120; GO:0008137; GO:0032981; GO:0042775; GO:0045271; GO:0051539
GN004212	GN004212.1	Q9VR07	48.4	550	586	943	4.61e-197	580	INE_DROME	Sodium- and chloride-dependent GABA transporter ine (Protein inebriated) (Protein receptor oscillation A)	Drosophila melanogaster (Fruit fly)	glial cell growth [GO:0042065]; glycine import across plasma membrane [GO:1903804]; multicellular organismal-level water homeostasis [GO:0050891]; neurotransmitter transport [GO:0006836]; perineurial glial growth [GO:0042066]; regulation of response to osmotic stress [GO:0047484]; response to water deprivation [GO:0009414]; sodium ion transmembrane transport [GO:0035725]; transmission of nerve impulse [GO:0019226]	amino acid:sodium symporter activity [GO:0005283]; neurotransmitter:sodium symporter activity [GO:0005328]; osmosensor activity [GO:0005034]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005034; GO:0005283; GO:0005328; GO:0005886; GO:0006836; GO:0009414; GO:0016020; GO:0016323; GO:0019226; GO:0035725; GO:0042065; GO:0042066; GO:0047484; GO:0050891; GO:1903804
GN004229	GN004229.1	Q9UA35	50.8	303	320	683	1.80e-97	305	S28A3_EPTST	Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT)	Eptatretus stoutii (Pacific hagfish)	purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]	purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]	plasma membrane [GO:0005886]	GO:0005886; GO:0015389; GO:0015390; GO:0015860; GO:0015864
GN004230	GN004230.1	Q9UA35	45.4	416	457	683	1.04e-123	378	S28A3_EPTST	Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT)	Eptatretus stoutii (Pacific hagfish)	purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]	purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenosine-specific:sodium symporter activity [GO:0015389]	plasma membrane [GO:0005886]	GO:0005886; GO:0015389; GO:0015390; GO:0015860; GO:0015864
GN004231	GN004231.1	B0JZ65	27.4	712	718	691	1.70e-76	263	LRWD1_XENTR	Leucine-rich repeat and WD repeat-containing protein 1 (ORC-associated protein) (ORCA) (Origin recognition complex-associated protein)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	chromatin organization [GO:0006325]; establishment of protein localization to chromatin [GO:0071169]	chromatin binding [GO:0003682]; histone H3K27me3 reader activity [GO:0061628]; methyl-CpG binding [GO:0008327]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; kinetochore [GO:0000776]; nuclear origin of replication recognition complex [GO:0005664]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	GO:0000776; GO:0000781; GO:0003682; GO:0005634; GO:0005664; GO:0005721; GO:0005813; GO:0006325; GO:0008327; GO:0061628; GO:0071169
GN004233	GN004233.1	Q9NXW9	48.1	158	140	302	1.30e-42	145	ALKB4_HUMAN	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-)	Homo sapiens (Human)	actomyosin structure organization [GO:0031032]; cleavage furrow ingression [GO:0036090]; demethylation [GO:0070988]; positive regulation of gene expression, epigenetic [GO:0141137]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; actin binding [GO:0003779]; broad specificity oxidative DNA demethylase activity [GO:0035516]; demethylase activity [GO:0032451]; DNA N6-methyladenine demethylase activity [GO:0141131]; protein demethylase activity [GO:0140457]	contractile ring [GO:0070938]; cytoplasm [GO:0005737]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003779; GO:0005634; GO:0005730; GO:0005737; GO:0016706; GO:0030496; GO:0031032; GO:0032451; GO:0035516; GO:0036090; GO:0070938; GO:0070988; GO:0140457; GO:0141131; GO:0141137
GN004234	GN004234.1	P17972	44.7	206	273	498	8.97e-51	176	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN004235	GN004235.1	P17972	33.5	173	290	498	4.27e-27	113	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN004240	GN004240.1	Q9UMZ2	26.6	1193	1400	1314	7.09e-57	220	SYNRG_HUMAN	Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin)	Homo sapiens (Human)	intracellular protein transport [GO:0006886]		AP-1 adaptor complex [GO:0030121]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]	GO:0005737; GO:0005794; GO:0006886; GO:0030121; GO:0030130; GO:0048471
GN004241	GN004241.1	P42577	78.4	167	171	174	8.02e-90	262	FRIS_LYMST	Soma ferritin (EC 1.16.3.1)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]	ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]	cytoplasm [GO:0005737]	GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008198; GO:0008199
GN004242	GN004242.1	Q99501	52.2	138	1453	681	3.76e-31	135	GA2L1_HUMAN	GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1)	Homo sapiens (Human)	actin crosslink formation [GO:0051764]; cellular response to starvation [GO:0009267]; microtubule bundle formation [GO:0001578]; negative regulation of microtubule depolymerization [GO:0007026]; protein localization to microtubule plus-end [GO:1904825]; regulation of microtubule polymerization or depolymerization [GO:0031110]	actin filament binding [GO:0051015]; cytoskeletal adaptor activity [GO:0008093]; microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; stress fiber [GO:0001725]	GO:0001578; GO:0001725; GO:0005737; GO:0007026; GO:0008017; GO:0008093; GO:0009267; GO:0031110; GO:0051015; GO:0051764; GO:1904825
GN004243	GN004243.1	A0A1L8HFX9	51.0	200	207	980	3.57e-53	186	G2L2L_XENLA	GAS2-like protein 2A (growth arrest specific 2 like 2 A)	Xenopus laevis (African clawed frog)	actin crosslink formation [GO:0051764]; microtubule bundle formation [GO:0001578]; protein localization to microtubule plus-end [GO:1904825]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of microtubule polymerization or depolymerization [GO:0031110]	actin filament binding [GO:0051015]; cytoskeletal adaptor activity [GO:0008093]; microtubule binding [GO:0008017]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; microtubule plus-end [GO:0035371]; stress fiber [GO:0001725]	GO:0001578; GO:0001725; GO:0005737; GO:0005884; GO:0008017; GO:0008093; GO:0031110; GO:0035371; GO:0051015; GO:0051764; GO:0060296; GO:1904825
GN004247	GN004247.1	Q96PB7	34.5	287	456	478	2.42e-44	164	NOE3_HUMAN	Noelin-3 (Olfactomedin-3) (Optimedin)	Homo sapiens (Human)	eye photoreceptor cell development [GO:0042462]; signal transduction [GO:0007165]		AMPA glutamate receptor complex [GO:0032281]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; synapse [GO:0045202]	GO:0005576; GO:0005794; GO:0007165; GO:0032281; GO:0042462; GO:0045202
GN004253	GN004253.1	Q6AZB8	35.0	246	289	349	1.19e-42	152	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN004259	GN004259.1	Q21268	35.3	170	220	290	1.48e-21	93.2	YMSO_CAEEL	UPF0046 protein K07C11.7	Caenorhabditis elegans		cyclic-nucleotide phosphodiesterase activity [GO:0004112]		GO:0004112
GN004260	GN004260.1	P17972	32.6	423	444	498	1.27e-62	213	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN004261	GN004261.1	P17972	32.2	422	444	498	1.87e-61	210	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN004262	GN004262.1	P17972	31.7	423	444	498	4.87e-62	212	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN004263	GN004263.1	P17972	36.6	164	155	498	2.68e-26	106	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN004264	GN004264.1	Q21268	33.7	163	229	290	2.43e-17	82.0	YMSO_CAEEL	UPF0046 protein K07C11.7	Caenorhabditis elegans		cyclic-nucleotide phosphodiesterase activity [GO:0004112]		GO:0004112
GN004265	GN004265.1	Q96DF8	47.8	90	90	476	2.57e-09	55.5	ESS2_HUMAN	Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2)	Homo sapiens (Human)	mRNA splicing, via spliceosome [GO:0000398]; nervous system development [GO:0007399]		catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]	GO:0000398; GO:0005634; GO:0007399; GO:0071013
GN004266	GN004266.1	Q7SYB5	26.5	317	705	612	8.17e-23	107	DEFI6_DANRE	Differentially expressed in FDCP 6 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	cell migration involved in gastrulation [GO:0042074]; convergent extension [GO:0060026]; convergent extension involved in gastrulation [GO:0060027]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0042074; GO:0060026; GO:0060027
GN004267	GN004267.1	Q4V7W8	48.1	212	242	246	5.60e-67	210	ETKMT_XENLA	Electron transfer flavoprotein beta subunit lysine methyltransferase (EC 2.1.1.-) (ETFB lysine methyltransferase) (ETFB-KMT) (Protein N-lysine methyltransferase METTL20)	Xenopus laevis (African clawed frog)	negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:1904736]	protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]	GO:0005737; GO:0005759; GO:0016279; GO:1904736
GN004268	GN004268.1	Q5FWL3	38.2	170	275	317	2.12e-30	119	RNF41_XENLA	E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)	Xenopus laevis (African clawed frog)	extrinsic apoptotic signaling pathway [GO:0097191]; protein polyubiquitination [GO:0000209]; regulation of canonical NF-kappaB signal transduction [GO:0043122]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]		GO:0000209; GO:0004842; GO:0043122; GO:0061630; GO:0097191
GN004271	GN004271.1	Q9NRA2	35.4	401	580	495	1.20e-76	254	S17A5_HUMAN	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)	Homo sapiens (Human)	carbohydrate derivative transport [GO:1901264]; monoatomic anion transport [GO:0006820]; neurotransmitter loading into synaptic vesicle [GO:0098700]; sialic acid transport [GO:0015739]	carbohydrate:proton symporter activity [GO:0005351]; D-glucuronate transmembrane transporter activity [GO:0042880]; glucuronate transmembrane transporter activity [GO:0015135]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	GO:0005351; GO:0005764; GO:0005765; GO:0005886; GO:0006820; GO:0015135; GO:0015136; GO:0015538; GO:0015739; GO:0016020; GO:0016323; GO:0016324; GO:0030672; GO:0042880; GO:0098700; GO:0098978; GO:1901264
GN004272	GN004272.1	Q5Q0U0	37.6	117	275	495	1.60e-16	82.4	S17A5_RAT	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Solute carrier family 17 (Anion/sugar transporter), member 5) (Vesicular excitatory amino acid transporter) (VEAT)	Rattus norvegicus (Rat)	neurotransmitter loading into synaptic vesicle [GO:0098700]; response to bacterium [GO:0009617]; sialic acid transport [GO:0015739]	D-glucuronate transmembrane transporter activity [GO:0042880]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle [GO:0031410]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	GO:0005764; GO:0005765; GO:0005886; GO:0009617; GO:0015136; GO:0015538; GO:0015739; GO:0016323; GO:0016324; GO:0030672; GO:0031410; GO:0042880; GO:0098700; GO:0098978
GN004273	GN004273.1	Q03567	34.0	456	679	493	3.96e-77	258	SL172_CAEEL	Uncharacterized transporter slc-17.2	Caenorhabditis elegans		transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0016020; GO:0022857
GN004274	GN004274.1	Q9NRA2	30.4	388	664	495	5.40e-55	198	S17A5_HUMAN	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)	Homo sapiens (Human)	carbohydrate derivative transport [GO:1901264]; monoatomic anion transport [GO:0006820]; neurotransmitter loading into synaptic vesicle [GO:0098700]; sialic acid transport [GO:0015739]	carbohydrate:proton symporter activity [GO:0005351]; D-glucuronate transmembrane transporter activity [GO:0042880]; glucuronate transmembrane transporter activity [GO:0015135]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	GO:0005351; GO:0005764; GO:0005765; GO:0005886; GO:0006820; GO:0015135; GO:0015136; GO:0015538; GO:0015739; GO:0016020; GO:0016323; GO:0016324; GO:0030672; GO:0042880; GO:0098700; GO:0098978; GO:1901264
GN004275	GN004275.1	Q96DR7	40.6	505	1663	871	1.43e-107	368	ARHGQ_HUMAN	Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)	Homo sapiens (Human)	regulation of actin cytoskeleton organization [GO:0032956]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GO:0001726; GO:0005085; GO:0005829; GO:0005886; GO:0032956
GN004276	GN004276.1	P06734	36.5	126	255	321	6.44e-18	84.7	FCER2_HUMAN	Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form]	Homo sapiens (Human)	B cell antigen processing and presentation [GO:0002450]; defense response to bacterium [GO:0042742]; Fc receptor-mediated immune complex endocytosis [GO:0160006]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immune response [GO:0006955]; macrophage activation [GO:0042116]; positive regulation of gene expression [GO:0010628]	carbohydrate binding [GO:0030246]; IgE binding [GO:0019863]; integrin binding [GO:0005178]; low-affinity IgE receptor activity [GO:0019769]; pattern recognition receptor activity [GO:0038187]; protease binding [GO:0002020]	external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0002020; GO:0002450; GO:0005178; GO:0005576; GO:0005886; GO:0006955; GO:0009897; GO:0010628; GO:0019769; GO:0019863; GO:0030246; GO:0038096; GO:0038187; GO:0042116; GO:0042742; GO:0070062; GO:0160006
GN004277	GN004277.1	P58197	69.7	208	436	437	2.19e-90	283	AP2A_RAT	Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)	Rattus norvegicus (Rat)	anterior neuropore closure [GO:0021506]; basement membrane organization [GO:0071711]; bone morphogenesis [GO:0060349]; cellular response to iron ion [GO:0071281]; cornea development in camera-type eye [GO:0061303]; embryonic body morphogenesis [GO:0010172]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; embryonic pattern specification [GO:0009880]; epidermis morphogenesis [GO:0048730]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; forebrain neuron development [GO:0021884]; forelimb morphogenesis [GO:0035136]; inner ear morphogenesis [GO:0042472]; keratinocyte development [GO:0003334]; kidney development [GO:0001822]; lens induction in camera-type eye [GO:0060235]; lens morphogenesis in camera-type eye [GO:0002089]; metanephric nephron development [GO:0072210]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell development [GO:0014032]; neural tube closure [GO:0001843]; oculomotor nerve formation [GO:0021623]; optic cup structural organization [GO:0003409]; optic vesicle morphogenesis [GO:0003404]; outflow tract morphogenesis [GO:0003151]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron differentiation [GO:0045664]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; retina layer formation [GO:0010842]; roof of mouth development [GO:0060021]; Schwann cell development [GO:0014044]; sensory organ development [GO:0007423]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; sympathetic nervous system development [GO:0048485]; trigeminal nerve development [GO:0021559]	chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]	clathrin-coated pit [GO:0005905]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0000987; GO:0001227; GO:0001228; GO:0001501; GO:0001822; GO:0001843; GO:0002089; GO:0003151; GO:0003334; GO:0003404; GO:0003409; GO:0003677; GO:0003682; GO:0003700; GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0005905; GO:0006355; GO:0006357; GO:0007399; GO:0007423; GO:0007605; GO:0008285; GO:0009880; GO:0010172; GO:0010628; GO:0010842; GO:0014032; GO:0014044; GO:0021506; GO:0021559; GO:0021623; GO:0021884; GO:0030335; GO:0030501; GO:0032496; GO:0035115; GO:0035136; GO:0042059; GO:0042127; GO:0042472; GO:0042802; GO:0043066; GO:0043524; GO:0043525; GO:0043565; GO:0043588; GO:0045595; GO:0045664; GO:0045892; GO:0045893; GO:0045944; GO:0048485; GO:0048596; GO:0048701; GO:0048705; GO:0048730; GO:0060021; GO:0060235; GO:0060325; GO:0060349; GO:0061029; GO:0061303; GO:0070172; GO:0071281; GO:0071711; GO:0072210; GO:0140416; GO:1990837; GO:2000378
GN004278	GN004278.1	A4IF63	20.7	518	675	744	1.09e-23	110	TRIM2_BOVIN	Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2)	Bos taurus (Bovine)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0043161; GO:0043523; GO:0061630
GN004280	GN004280.1	Q0P5H9	55.9	281	280	440	6.58e-103	310	TTC5_BOVIN	Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Protein Strap)	Bos taurus (Bovine)	cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; positive regulation of RNA metabolic process [GO:0051254]; regulation of gene expression [GO:0010468]		cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006974; GO:0009267; GO:0010468; GO:0031410; GO:0051254
GN004281	GN004281.1	Q53G44	37.6	234	471	452	3.80e-42	158	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN004282	GN004282.1	Q6ZMY6	39.6	169	213	472	4.55e-18	85.1	WDR88_HUMAN	WD repeat-containing protein 88 (PQQ repeat and WD repeat-containing protein)	Homo sapiens (Human)				
GN004283	GN004283.1	Q6ZQ89	62.7	287	308	909	1.89e-110	343	MARH6_MOUSE	E3 ubiquitin-protein ligase MARCHF6 (EC 2.3.2.27) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) (RING-type E3 ubiquitin transferase MARCHF6)	Mus musculus (Mouse)	negative regulation of cholesterol biosynthetic process [GO:0045541]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]	enzyme binding [GO:0019899]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0004842; GO:0005783; GO:0005789; GO:0008270; GO:0010498; GO:0016020; GO:0016567; GO:0019899; GO:0031624; GO:0043161; GO:0045541; GO:0061630; GO:0070936; GO:1990381
GN004286	GN004286.1	P48148	77.7	188	193	192	1.47e-104	301	RHO1_DROME	Ras-like GTP-binding protein Rho1 (EC 3.6.5.2)	Drosophila melanogaster (Fruit fly)	actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; adherens junction maintenance [GO:0034334]; apical constriction [GO:0003383]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell elongation involved in imaginal disc-derived wing morphogenesis [GO:0090254]; cell migration [GO:0016477]; cell projection organization [GO:0030030]; cellularization [GO:0007349]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; determination of left/right symmetry [GO:0007368]; dorsal closure [GO:0007391]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; establishment of planar polarity of embryonic epithelium [GO:0042249]; establishment of protein localization [GO:0045184]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; gastrulation involving germ band extension [GO:0010004]; germ-band extension [GO:0007377]; glial cell migration [GO:0008347]; hemocyte migration [GO:0035099]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing hair organization [GO:0035317]; lumen formation, open tracheal system [GO:0035149]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; melanization defense response [GO:0035006]; mitotic actomyosin contractile ring assembly [GO:1903475]; mitotic cytokinesis [GO:0000281]; mitotic cytokinesis, division site positioning [GO:1902408]; motor neuron axon guidance [GO:0008045]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuroblast proliferation [GO:0007405]; neuron projection morphogenesis [GO:0048812]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of wound healing [GO:0090303]; posterior midgut invagination [GO:0007374]; protein localization involved in establishment of planar polarity [GO:0090251]; protein localization to adherens junction [GO:0071896]; pseudocleavage involved in syncytial blastoderm formation [GO:0030589]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actomyosin structure organization [GO:0110020]; regulation of axonogenesis [GO:0050770]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]; regulation of embryonic cell shape [GO:0016476]; regulation of filopodium assembly [GO:0051489]; regulation of locomotor rhythm [GO:1904059]; regulation of Malpighian tubule size [GO:0035298]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; response to wounding [GO:0009611]; salivary gland morphogenesis [GO:0007435]; small GTPase-mediated signal transduction [GO:0007264]; spiracle morphogenesis, open tracheal system [GO:0035277]; tracheal pit formation in open tracheal system [GO:0035202]; ventral furrow formation [GO:0007370]; wound healing [GO:0042060]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901]	apical cortex [GO:0045179]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; cell hair [GO:0070451]; cell-cell contact zone [GO:0044291]; cleavage furrow rim [GO:0090688]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	GO:0000281; GO:0001745; GO:0003383; GO:0003924; GO:0003925; GO:0005525; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005938; GO:0006897; GO:0007015; GO:0007264; GO:0007298; GO:0007349; GO:0007368; GO:0007370; GO:0007374; GO:0007377; GO:0007391; GO:0007395; GO:0007405; GO:0007411; GO:0007422; GO:0007424; GO:0007435; GO:0007480; GO:0008045; GO:0008347; GO:0009611; GO:0010004; GO:0016324; GO:0016328; GO:0016476; GO:0016477; GO:0019900; GO:0019901; GO:0030030; GO:0030036; GO:0030334; GO:0030589; GO:0030866; GO:0030950; GO:0032456; GO:0032956; GO:0034334; GO:0035006; GO:0035099; GO:0035149; GO:0035159; GO:0035202; GO:0035277; GO:0035298; GO:0035317; GO:0042060; GO:0042249; GO:0044291; GO:0045179; GO:0045184; GO:0045199; GO:0046663; GO:0048812; GO:0048813; GO:0050770; GO:0051017; GO:0051489; GO:0051493; GO:0070252; GO:0070451; GO:0070593; GO:0071896; GO:0071902; GO:0090090; GO:0090251; GO:0090254; GO:0090303; GO:0090688; GO:0110020; GO:1901739; GO:1902408; GO:1903475; GO:1904059
GN004287	GN004287.1	P48148	75.0	188	193	192	7.74e-100	289	RHO1_DROME	Ras-like GTP-binding protein Rho1 (EC 3.6.5.2)	Drosophila melanogaster (Fruit fly)	actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; adherens junction maintenance [GO:0034334]; apical constriction [GO:0003383]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell elongation involved in imaginal disc-derived wing morphogenesis [GO:0090254]; cell migration [GO:0016477]; cell projection organization [GO:0030030]; cellularization [GO:0007349]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; determination of left/right symmetry [GO:0007368]; dorsal closure [GO:0007391]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; establishment of planar polarity of embryonic epithelium [GO:0042249]; establishment of protein localization [GO:0045184]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; gastrulation involving germ band extension [GO:0010004]; germ-band extension [GO:0007377]; glial cell migration [GO:0008347]; hemocyte migration [GO:0035099]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing hair organization [GO:0035317]; lumen formation, open tracheal system [GO:0035149]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; melanization defense response [GO:0035006]; mitotic actomyosin contractile ring assembly [GO:1903475]; mitotic cytokinesis [GO:0000281]; mitotic cytokinesis, division site positioning [GO:1902408]; motor neuron axon guidance [GO:0008045]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuroblast proliferation [GO:0007405]; neuron projection morphogenesis [GO:0048812]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of wound healing [GO:0090303]; posterior midgut invagination [GO:0007374]; protein localization involved in establishment of planar polarity [GO:0090251]; protein localization to adherens junction [GO:0071896]; pseudocleavage involved in syncytial blastoderm formation [GO:0030589]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actomyosin structure organization [GO:0110020]; regulation of axonogenesis [GO:0050770]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]; regulation of embryonic cell shape [GO:0016476]; regulation of filopodium assembly [GO:0051489]; regulation of locomotor rhythm [GO:1904059]; regulation of Malpighian tubule size [GO:0035298]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; response to wounding [GO:0009611]; salivary gland morphogenesis [GO:0007435]; small GTPase-mediated signal transduction [GO:0007264]; spiracle morphogenesis, open tracheal system [GO:0035277]; tracheal pit formation in open tracheal system [GO:0035202]; ventral furrow formation [GO:0007370]; wound healing [GO:0042060]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901]	apical cortex [GO:0045179]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; cell hair [GO:0070451]; cell-cell contact zone [GO:0044291]; cleavage furrow rim [GO:0090688]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	GO:0000281; GO:0001745; GO:0003383; GO:0003924; GO:0003925; GO:0005525; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005938; GO:0006897; GO:0007015; GO:0007264; GO:0007298; GO:0007349; GO:0007368; GO:0007370; GO:0007374; GO:0007377; GO:0007391; GO:0007395; GO:0007405; GO:0007411; GO:0007422; GO:0007424; GO:0007435; GO:0007480; GO:0008045; GO:0008347; GO:0009611; GO:0010004; GO:0016324; GO:0016328; GO:0016476; GO:0016477; GO:0019900; GO:0019901; GO:0030030; GO:0030036; GO:0030334; GO:0030589; GO:0030866; GO:0030950; GO:0032456; GO:0032956; GO:0034334; GO:0035006; GO:0035099; GO:0035149; GO:0035159; GO:0035202; GO:0035277; GO:0035298; GO:0035317; GO:0042060; GO:0042249; GO:0044291; GO:0045179; GO:0045184; GO:0045199; GO:0046663; GO:0048812; GO:0048813; GO:0050770; GO:0051017; GO:0051489; GO:0051493; GO:0070252; GO:0070451; GO:0070593; GO:0071896; GO:0071902; GO:0090090; GO:0090251; GO:0090254; GO:0090303; GO:0090688; GO:0110020; GO:1901739; GO:1902408; GO:1903475; GO:1904059
GN004288	GN004288.1	Q5XGP7	27.5	255	270	330	4.42e-21	94.0	SKA2A_XENLA	Src kinase-associated phosphoprotein 2-A	Xenopus laevis (African clawed frog)			cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886
GN004289	GN004289.1	E6ZIJ1	41.8	545	923	707	2.74e-137	429	HOIL1_DICLA	RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (Heme-oxidized IRP2 ubiquitin ligase 1 homolog) (HOIL-1) (Heme-oxidized IRP2 ubiquitin transferase 1 homolog)	Dicentrarchus labrax (European seabass) (Morone labrax)	defense response to bacterium [GO:0042742]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein linear polyubiquitination [GO:0097039]	ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]	LUBAC complex [GO:0071797]	GO:0042742; GO:0043123; GO:0043130; GO:0043161; GO:0061630; GO:0071797; GO:0097039
GN004290	GN004290.1	Q6PGU2	58.7	230	241	247	4.02e-82	248	MAF1_DANRE	Repressor of RNA polymerase III transcription MAF1 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	negative regulation of transcription by RNA polymerase III [GO:0016480]	RNA polymerase III core binding [GO:0000994]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000994; GO:0005634; GO:0005737; GO:0016480
GN004291	GN004291.1	Q1RMU2	36.1	926	959	953	1.06e-167	518	CYLD_BOVIN	Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)	Bos taurus (Bovine)	innate immune response [GO:0045087]; necroptotic process [GO:0070266]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-18-mediated signaling pathway [GO:2000493]; negative regulation of JNK cascade [GO:0046329]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of p38MAPK cascade [GO:1903753]; protein deubiquitination [GO:0016579]; protein K63-linked deubiquitination [GO:0070536]; protein linear deubiquitination [GO:1990108]; regulation of cilium assembly [GO:1902017]; regulation of inflammatory response [GO:0050727]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; regulation of mitotic cell cycle [GO:0007346]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]	cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819]	GO:0004843; GO:0005813; GO:0005819; GO:0005829; GO:0005886; GO:0007346; GO:0008270; GO:0010803; GO:0016579; GO:0036064; GO:0043124; GO:0045087; GO:0046329; GO:0048471; GO:0050727; GO:0050728; GO:0061578; GO:0070266; GO:0070536; GO:0090090; GO:0097542; GO:1901223; GO:1902017; GO:1903753; GO:1990108; GO:2000493; GO:2001242
GN004292	GN004292.1	Q5ZJX5	38.1	417	456	468	3.37e-80	259	MEAK7_CHICK	MTOR-associated protein MEAK7 (MEAK7) (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1)	Gallus gallus (Chicken)	positive regulation of protein localization to lysosome [GO:0150032]; regulation of cell migration [GO:0030334]; regulation of cell population proliferation [GO:0042127]; response to amino acid [GO:0043200]; response to insulin [GO:0032868]; response to nutrient levels [GO:0031667]; response to oxidative stress [GO:0006979]; TOR signaling [GO:0031929]		cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005764; GO:0005765; GO:0006979; GO:0016020; GO:0030334; GO:0031667; GO:0031929; GO:0032868; GO:0042127; GO:0043200; GO:0150032
GN004293	GN004293.1	P58197	70.2	208	436	437	1.97e-91	286	AP2A_RAT	Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)	Rattus norvegicus (Rat)	anterior neuropore closure [GO:0021506]; basement membrane organization [GO:0071711]; bone morphogenesis [GO:0060349]; cellular response to iron ion [GO:0071281]; cornea development in camera-type eye [GO:0061303]; embryonic body morphogenesis [GO:0010172]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; embryonic pattern specification [GO:0009880]; epidermis morphogenesis [GO:0048730]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; forebrain neuron development [GO:0021884]; forelimb morphogenesis [GO:0035136]; inner ear morphogenesis [GO:0042472]; keratinocyte development [GO:0003334]; kidney development [GO:0001822]; lens induction in camera-type eye [GO:0060235]; lens morphogenesis in camera-type eye [GO:0002089]; metanephric nephron development [GO:0072210]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell development [GO:0014032]; neural tube closure [GO:0001843]; oculomotor nerve formation [GO:0021623]; optic cup structural organization [GO:0003409]; optic vesicle morphogenesis [GO:0003404]; outflow tract morphogenesis [GO:0003151]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron differentiation [GO:0045664]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; retina layer formation [GO:0010842]; roof of mouth development [GO:0060021]; Schwann cell development [GO:0014044]; sensory organ development [GO:0007423]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; sympathetic nervous system development [GO:0048485]; trigeminal nerve development [GO:0021559]	chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]	clathrin-coated pit [GO:0005905]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0000987; GO:0001227; GO:0001228; GO:0001501; GO:0001822; GO:0001843; GO:0002089; GO:0003151; GO:0003334; GO:0003404; GO:0003409; GO:0003677; GO:0003682; GO:0003700; GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0005905; GO:0006355; GO:0006357; GO:0007399; GO:0007423; GO:0007605; GO:0008285; GO:0009880; GO:0010172; GO:0010628; GO:0010842; GO:0014032; GO:0014044; GO:0021506; GO:0021559; GO:0021623; GO:0021884; GO:0030335; GO:0030501; GO:0032496; GO:0035115; GO:0035136; GO:0042059; GO:0042127; GO:0042472; GO:0042802; GO:0043066; GO:0043524; GO:0043525; GO:0043565; GO:0043588; GO:0045595; GO:0045664; GO:0045892; GO:0045893; GO:0045944; GO:0048485; GO:0048596; GO:0048701; GO:0048705; GO:0048730; GO:0060021; GO:0060235; GO:0060325; GO:0060349; GO:0061029; GO:0061303; GO:0070172; GO:0071281; GO:0071711; GO:0072210; GO:0140416; GO:1990837; GO:2000378
GN004294	GN004294.1	Q8CA72	37.6	595	621	597	5.87e-59	211	GAN_MOUSE	Gigaxonin	Mus musculus (Mouse)	cytoskeleton organization [GO:0007010]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]	GO:0005737; GO:0007010; GO:0015630; GO:0016567; GO:0031463; GO:0043161; GO:1990756
GN004295	GN004295.1	Q6NSR8	57.1	520	520	524	1.52e-206	586	PEPL1_MOUSE	Probable aminopeptidase NPEPL1 (EC 3.4.11.-) (Aminopeptidase-like 1)	Mus musculus (Mouse)	proteolysis [GO:0006508]	manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]	cytoplasm [GO:0005737]	GO:0005737; GO:0006508; GO:0030145; GO:0070006
GN004297	GN004297.1	O60547	74.1	293	293	372	3.91e-161	456	GMDS_HUMAN	GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)	Homo sapiens (Human)	'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; GDP-L-fucose biosynthetic process [GO:0042350]; GDP-mannose metabolic process [GO:0019673]; Notch signaling pathway [GO:0007219]	GDP-mannose 4,6-dehydratase activity [GO:0008446]; identical protein binding [GO:0042802]; NADP+ binding [GO:0070401]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0005737; GO:0005829; GO:0007219; GO:0008446; GO:0019673; GO:0042350; GO:0042351; GO:0042802; GO:0070062; GO:0070401
GN004298	GN004298.1	Q64731	79.8	104	385	336	2.21e-56	191	FOXL1_MOUSE	Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6)	Mus musculus (Mouse)	anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; heart development [GO:0007507]; Peyer's patch morphogenesis [GO:0061146]; proteoglycan biosynthetic process [GO:0030166]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]; visceral mesoderm-endoderm interaction involved in midgut development [GO:0007495]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0006357; GO:0007495; GO:0007507; GO:0009653; GO:0030111; GO:0030154; GO:0030166; GO:0043565; GO:0061146
GN004300	GN004300.1	Q9PVZ3	39.2	536	502	492	1.32e-78	257	FXC1A_XENLA	Forkhead box protein C1-A (FoxC1) (Fork head domain-related protein 11) (XFD-11)	Xenopus laevis (African clawed frog)	anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cellular response to chemokine [GO:1990869]; chemokine-mediated signaling pathway [GO:0070098]; DNA-templated transcription [GO:0006351]; mesoderm development [GO:0007498]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephros development [GO:0048793]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]	GO:0000976; GO:0000978; GO:0000981; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0006357; GO:0007155; GO:0007498; GO:0009653; GO:0030154; GO:0045944; GO:0048793; GO:0070098; GO:1990869
GN004301	GN004301.1	Q8BLF1	30.0	240	303	408	1.98e-18	88.2	NCEH1_MOUSE	Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1) (Chlorpyrifos oxon-binding protein) (CPO-BP)	Mus musculus (Mouse)	ether lipid metabolic process [GO:0046485]; protein dephosphorylation [GO:0006470]; xenobiotic metabolic process [GO:0006805]	acetylalkylglycerol acetylhydrolase activity [GO:0047378]; phosphate ion binding [GO:0042301]; serine hydrolase activity [GO:0017171]; sterol ester esterase activity [GO:0004771]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004771; GO:0005886; GO:0006470; GO:0006805; GO:0016020; GO:0017171; GO:0042301; GO:0046485; GO:0047378
GN004302	GN004302.1	Q9NPI1	41.6	262	337	651	1.26e-50	181	BRD7_HUMAN	Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]	histone binding [GO:0042393]; histone H3K14ac reader activity [GO:0140015]; histone reader activity [GO:0140566]; p53 binding [GO:0002039]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RSC-type complex [GO:0016586]	GO:0000776; GO:0000785; GO:0000976; GO:0002039; GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006338; GO:0006357; GO:0007346; GO:0016363; GO:0016586; GO:0030071; GO:0042393; GO:0045582; GO:0045597; GO:0045663; GO:0045815; GO:0045892; GO:0070316; GO:0140015; GO:0140566; GO:2000045; GO:2000134; GO:2000781; GO:2000819
GN004304	GN004304.1	P00491	52.9	263	332	289	3.03e-100	300	PNPH_HUMAN	Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase)	Homo sapiens (Human)	allantoin metabolic process [GO:0000255]; dAMP catabolic process [GO:0046059]; deoxyadenosine catabolic process [GO:0006157]; deoxyguanosine catabolic process [GO:0006161]; deoxyinosine catabolic process [GO:0006149]; guanosine catabolic process [GO:0046115]; immune response [GO:0006955]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; NAD+ biosynthetic process via the salvage pathway [GO:0034355]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; nucleotide biosynthetic process [GO:0009165]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of T cell proliferation [GO:0042102]; purine-containing compound salvage [GO:0043101]; response to xenobiotic stimulus [GO:0009410]; urate biosynthetic process [GO:0034418]	guanosine phosphorylase activity [GO:0047975]; identical protein binding [GO:0042802]; nucleoside binding [GO:0001882]; phosphate ion binding [GO:0042301]; purine nucleobase binding [GO:0002060]; purine-nucleoside phosphorylase activity [GO:0004731]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]	GO:0000255; GO:0001882; GO:0002060; GO:0004731; GO:0005576; GO:0005737; GO:0005829; GO:0006139; GO:0006148; GO:0006149; GO:0006157; GO:0006161; GO:0006204; GO:0006738; GO:0006955; GO:0009165; GO:0009410; GO:0032743; GO:0034355; GO:0034418; GO:0034774; GO:0042102; GO:0042301; GO:0042802; GO:0043101; GO:0046059; GO:0046115; GO:0046638; GO:0047975; GO:0070062; GO:1904813
GN004305	GN004305.1	Q3ZBH3	24.6	264	282	253	2.02e-16	80.1	CD151_BOVIN	CD151 antigen (CD antigen CD151)	Bos taurus (Bovine)	cell migration [GO:0016477]	integrin binding [GO:0005178]	plasma membrane [GO:0005886]	GO:0005178; GO:0005886; GO:0016477
GN004306	GN004306.1	P32748	60.8	153	176	405	4.12e-64	205	PYRD_DROME	Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (Dihydroorotate oxidase) (EC 1.3.5.2)	Drosophila melanogaster (Fruit fly)	'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]	dihydroorotate dehydrogenase (quinone) activity [GO:0106430]; dihydroorotate dehydrogenase activity [GO:0004152]	mitochondrial inner membrane [GO:0005743]	GO:0004152; GO:0005743; GO:0006207; GO:0044205; GO:0106430
GN004307	GN004307.1	Q8BJ64	64.7	569	1234	596	5.04e-262	757	CHDH_MOUSE	Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)	Mus musculus (Mouse)	glycine betaine biosynthetic process from choline [GO:0019285]	choline dehydrogenase activity [GO:0008812]; flavin adenine dinucleotide binding [GO:0050660]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0005739; GO:0005741; GO:0005743; GO:0008812; GO:0019285; GO:0050660
GN004314	GN004314.1	O61366	34.4	212	235	1302	1.07e-30	122	GPRS_DROME	Serine-enriched protein	Drosophila melanogaster (Fruit fly)				
GN004315	GN004315.1	Q9Z0J5	60.7	468	467	526	2.43e-204	578	TRXR2_RAT	Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Thioredoxin reductase TR3)	Rattus norvegicus (Rat)	cell redox homeostasis [GO:0045454]; heart development [GO:0007507]; hemopoiesis [GO:0030097]; protein-containing complex assembly [GO:0065003]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to oxygen radical [GO:0000305]; response to selenium ion [GO:0010269]	flavin adenine dinucleotide binding [GO:0050660]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; thioredoxin-disulfide reductase (NADPH) activity [GO:0004791]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]	GO:0000305; GO:0004791; GO:0005739; GO:0005829; GO:0007507; GO:0010269; GO:0030097; GO:0030424; GO:0030425; GO:0042542; GO:0042803; GO:0043025; GO:0044877; GO:0045454; GO:0050660; GO:0055093; GO:0065003
GN004317	GN004317.1	Q64429	31.7	479	513	543	1.28e-64	222	CP1B1_MOUSE	Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1) (Cytochrome P450CMEF) (Cytochrome P450EF) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)	Mus musculus (Mouse)	angiogenesis [GO:0001525]; arachidonate metabolic process [GO:0019369]; benzene-containing compound metabolic process [GO:0042537]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to toxic substance [GO:0097237]; collagen fibril organization [GO:0030199]; DNA modification [GO:0006304]; endothelial cell migration [GO:0043542]; endothelial cell-cell adhesion [GO:0071603]; estrogen metabolic process [GO:0008210]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; lipid catabolic process [GO:0016042]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of translation [GO:0045727]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to toxic substance [GO:0009636]; retina vasculature development in camera-type eye [GO:0061298]; retinal blood vessel morphogenesis [GO:0061304]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; steroid metabolic process [GO:0008202]; toxin metabolic process [GO:0009404]; trabecular meshwork development [GO:0002930]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	arachidonate 11,12-epoxygenase activity [GO:0008405]; arachidonate 14,15-epoxygenase activity [GO:0008404]; arachidonate 8,9-epoxygenase activity [GO:0106302]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]	endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]	GO:0001525; GO:0002930; GO:0004497; GO:0005506; GO:0005739; GO:0005789; GO:0006304; GO:0006706; GO:0006805; GO:0006809; GO:0007155; GO:0008202; GO:0008210; GO:0008285; GO:0008395; GO:0008404; GO:0008405; GO:0008631; GO:0009404; GO:0009636; GO:0010575; GO:0014911; GO:0016042; GO:0016491; GO:0016712; GO:0019369; GO:0020037; GO:0030199; GO:0030336; GO:0033629; GO:0042178; GO:0042537; GO:0042572; GO:0042574; GO:0043065; GO:0043542; GO:0045727; GO:0045766; GO:0046427; GO:0048514; GO:0050649; GO:0061298; GO:0061304; GO:0070301; GO:0071603; GO:0097237; GO:0101020; GO:0101021; GO:0106256; GO:0106302; GO:2000377; GO:2000379; GO:2000573
GN004321	GN004321.1	Q5ZIJ9	54.6	952	906	954	2.45e-234	688	MIB2_CHICK	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (RING-type E3 ubiquitin transferase MIB2)	Gallus gallus (Chicken)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN004322	GN004322.1	Q8K0S0	34.2	187	179	330	4.26e-23	96.7	PHYIP_MOUSE	Phytanoyl-CoA hydroxylase-interacting protein (Phytanoyl-CoA hydroxylase-associated protein 1) (PAHX-AP1) (PAHXAP1)	Mus musculus (Mouse)	intracellular protein localization [GO:0008104]	protein tyrosine kinase binding [GO:1990782]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0005739; GO:0008104; GO:1990782
GN004323	GN004323.1	Q0V9U8	34.1	179	179	376	1.03e-23	99.0	PHIPL_XENTR	Phytanoyl-CoA hydroxylase-interacting protein-like	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			cytoplasm [GO:0005737]	GO:0005737
GN004325	GN004325.1	Q810B6	53.1	1173	1159	1169	0.0	1031	ANFY1_MOUSE	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif) (Rab5-binding and ankyrin repeats-containing protein) (Rabankyrin-5) (Rank-5)	Mus musculus (Mouse)	endocytosis [GO:0006897]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; Golgi to lysosome transport [GO:0090160]; positive regulation of pinocytosis [GO:0048549]; retrograde transport, endosome to Golgi [GO:0042147]	metal ion binding [GO:0046872]; phosphatidylinositol phosphate binding [GO:1901981]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; macropinosome [GO:0044354]; membrane [GO:0016020]; retromer complex [GO:0030904]	GO:0005737; GO:0005768; GO:0005769; GO:0005829; GO:0006897; GO:0010008; GO:0016020; GO:0016197; GO:0030904; GO:0031267; GO:0031410; GO:0034058; GO:0042147; GO:0044354; GO:0046872; GO:0048549; GO:0090160; GO:1901981
GN004326	GN004326.1	Q9D404	56.2	418	426	459	5.39e-154	446	OXSM_MOUSE	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase)	Mus musculus (Mouse)	acyl-CoA metabolic process [GO:0006637]; medium-chain fatty acid biosynthetic process [GO:0051792]; short-chain fatty acid biosynthetic process [GO:0051790]	3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0004315; GO:0005739; GO:0005829; GO:0006637; GO:0051790; GO:0051792
GN004327	GN004327.1	Q148G5	50.7	227	325	593	3.65e-64	216	PROD_BOVIN	Proline dehydrogenase 1, mitochondrial (EC 1.5.5.2) (Proline oxidase)	Bos taurus (Bovine)	L-proline catabolic process [GO:0006562]	FAD binding [GO:0071949]; proline dehydrogenase activity [GO:0004657]	mitochondrial matrix [GO:0005759]	GO:0004657; GO:0005759; GO:0006562; GO:0071949
GN004328	GN004328.1	Q61382	49.5	461	478	470	1.39e-175	504	TRAF4_MOUSE	TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich motif associated to RING and Traf domains protein 1)	Mus musculus (Mouse)	cell surface receptor signaling pathway [GO:0007166]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein kinase activity [GO:0045860]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; respiratory gaseous exchange by respiratory system [GO:0007585]; respiratory tube development [GO:0030323]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270]	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0001650; GO:0005164; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005923; GO:0007166; GO:0007585; GO:0008270; GO:0019901; GO:0030323; GO:0031625; GO:0031996; GO:0035591; GO:0042802; GO:0042981; GO:0043122; GO:0043161; GO:0045860; GO:0046330; GO:0048471; GO:0050699; GO:0061630
GN004339	GN004339.1	Q04336	35.8	120	292	1088	1.57e-13	74.3	YM54_YEAST	Uncharacterized protein YMR196W	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	oligosaccharide metabolic process [GO:0009311]	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [GO:0004573]	cytoplasm [GO:0005737]	GO:0004573; GO:0005737; GO:0009311
GN004342	GN004342.1	Q09428	35.4	1735	1694	1581	0.0	994	ABCC8_HUMAN	ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1)	Homo sapiens (Human)	female pregnancy [GO:0007565]; intracellular glucose homeostasis [GO:0001678]; memory [GO:0007613]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood-brain barrier permeability [GO:1905604]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of insulin secretion [GO:0046676]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of neuroblast migration [GO:0061855]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of tight junction disassembly [GO:1905075]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of uterine smooth muscle relaxation [GO:1900721]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of insulin secretion [GO:0050796]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to pH [GO:0009268]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; transmembrane transport [GO:0055085]; visual learning [GO:0008542]	ABC-type transporter activity [GO:0140359]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; potassium channel activity [GO:0005267]; sulfonylurea receptor activity [GO:0008281]; transmembrane transporter binding [GO:0044325]	inward rectifying potassium channel [GO:0008282]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; presynaptic membrane [GO:0042734]; sarcolemma [GO:0042383]; synaptic vesicle membrane [GO:0030672]	GO:0001678; GO:0005267; GO:0005524; GO:0005886; GO:0006813; GO:0007565; GO:0007613; GO:0008281; GO:0008282; GO:0008542; GO:0009268; GO:0009410; GO:0010043; GO:0010989; GO:0015272; GO:0016525; GO:0016887; GO:0019829; GO:0030672; GO:0031004; GO:0032496; GO:0032760; GO:0032868; GO:0035774; GO:0042383; GO:0042734; GO:0043268; GO:0043531; GO:0044325; GO:0046676; GO:0050796; GO:0055085; GO:0060253; GO:0061855; GO:0071805; GO:0140359; GO:1900721; GO:1905075; GO:1905604; GO:1990573
GN004343	GN004343.1	P49024	54.9	51	94	559	2.21e-09	55.8	PAXI_CHICK	Paxillin	Gallus gallus (Chicken)	endothelial cell migration [GO:0043542]; response to muscle stretch [GO:0035994]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]	vinculin binding [GO:0017166]	cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	GO:0001725; GO:0005886; GO:0005911; GO:0005925; GO:0005938; GO:0007179; GO:0017166; GO:0034446; GO:0035994; GO:0043542
GN004344	GN004344.1	F1NV61	30.5	118	340	309	3.08e-10	63.9	CASP7_CHICK	Caspase-7 (CASP-7) (EC 3.4.22.60) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]	Gallus gallus (Chicken)	apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; execution phase of apoptosis [GO:0097194]; lymphocyte apoptotic process [GO:0070227]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of plasma membrane repair [GO:1905686]; proteolysis [GO:0006508]	aspartic-type endopeptidase activity [GO:0004190]; cysteine-type endopeptidase activity [GO:0004197]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0003723; GO:0004190; GO:0004197; GO:0005576; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0042742; GO:0043525; GO:0070227; GO:0097194; GO:1905686
GN004345	GN004345.1	O08738	28.1	274	401	276	4.25e-18	87.0	CASP6_MOUSE	Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]	Mus musculus (Mouse)	activation of innate immune response [GO:0002218]; acute inflammatory response to non-antigenic stimulus [GO:0002525]; apoptotic process [GO:0006915]; axonal fasciculation [GO:0007413]; cellular response to staurosporine [GO:0072734]; epithelial cell differentiation [GO:0030855]; hepatocyte apoptotic process [GO:0097284]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of apoptotic process [GO:0043065]; positive regulation of necroptotic process [GO:0060545]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of retinal cell programmed cell death [GO:0046670]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of programmed cell death [GO:0043067]; response to cytokine [GO:0034097]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to iron ion [GO:0010039]	cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]	axon [GO:0030424]; caspase complex [GO:0008303]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001650; GO:0002218; GO:0002525; GO:0004175; GO:0004197; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007413; GO:0008303; GO:0009749; GO:0010039; GO:0016540; GO:0030424; GO:0030855; GO:0034097; GO:0042542; GO:0042802; GO:0043025; GO:0043065; GO:0043067; GO:0043525; GO:0046670; GO:0060545; GO:0070269; GO:0072332; GO:0072734; GO:0090200; GO:0097284
GN004348	GN004348.1	Q86Z23	28.6	147	165	238	3.19e-11	62.8	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN004351	GN004351.1	B7ZRU9	31.3	684	724	1055	5.87e-20	99.0	EVI1A_XENLA	MDS1 and EVI1 complex locus protein EVI1-A (Ecotropic virus integration site 1 protein homolog-A) (Evi-1) (xEvi-1)	Xenopus laevis (African clawed frog)	negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pronephric distal tubule morphogenesis [GO:0039013]; pronephric duct development [GO:0039022]; pronephros development [GO:0048793]; proximal/distal pattern formation involved in pronephric nephron development [GO:0072196]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0001228; GO:0005634; GO:0006357; GO:0016607; GO:0039013; GO:0039022; GO:0045892; GO:0048793; GO:0072196
GN004352	GN004352.1	Q5ZMP6	84.9	438	438	433	1.18e-275	754	AP2M1_CHICK	AP-2 complex subunit mu (AP-2 mu chain) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein)	Gallus gallus (Chicken)	clathrin-dependent endocytosis [GO:0072583]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]	clathrin-cargo adaptor activity [GO:0035615]	AP-2 adaptor complex [GO:0030122]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GO:0005829; GO:0005886; GO:0006886; GO:0006896; GO:0008021; GO:0030122; GO:0035615; GO:0072583
GN004353	GN004353.1	P13732	75.8	120	137	130	4.03e-60	184	RL22_TRIGR	Large ribosomal subunit protein eL22 (60S ribosomal protein L22) (Development-specific protein 217)	Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla)	cytoplasmic translation [GO:0002181]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; ribosome [GO:0005840]	GO:0002181; GO:0003723; GO:0003735; GO:0005737; GO:0005840
GN004357	GN004357.1	Q7TT41	30.0	307	321	619	3.73e-30	123	MOXD2_MOUSE	DBH-like monooxygenase protein 2 (EC 1.14.17.-) (Dopamine-beta-hydroxylase-like protein)	Mus musculus (Mouse)		copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]	secretory granule membrane [GO:0030667]	GO:0004500; GO:0005507; GO:0016715; GO:0030667
GN004360	GN004360.1	P29594	30.4	280	340	452	4.63e-32	127	CASP2_MOUSE	Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]	Mus musculus (Mouse)	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; ectopic germ cell programmed cell death [GO:0035234]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; luteolysis [GO:0001554]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; neural retina development [GO:0003407]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]; release of cytochrome c from mitochondria [GO:0001836]	cysteine-type endopeptidase activity [GO:0004197]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	caspase complex [GO:0008303]; cytoplasm [GO:0005737]; endopeptidase complex [GO:1905369]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0001554; GO:0001836; GO:0003407; GO:0004197; GO:0005634; GO:0005730; GO:0005737; GO:0005739; GO:0006915; GO:0006974; GO:0008303; GO:0008630; GO:0016485; GO:0019904; GO:0030330; GO:0035234; GO:0042802; GO:0043065; GO:0043066; GO:0043525; GO:0060546; GO:0071260; GO:0097190; GO:0097192; GO:1905369; GO:2001235
GN004363	GN004363.1	Q9UUA2	26.6	354	563	805	2.30e-15	83.2	PIF1_SCHPO	ATP-dependent DNA helicase pfh1 (EC 5.6.2.3) (DNA 5'-3' helicase pfh1) (DNA repair and recombination helicase pfh1) (PIF1 helicase homolog) (RRM3/PIF1 homolog 1)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand elongation involved in mitotic DNA replication [GO:1902983]; mitochondrial DNA repair [GO:0043504]; mitotic recombination-dependent replication fork processing [GO:1990426]; removal of RNA primer involved in mitotic DNA replication [GO:1903469]; replication fork processing [GO:0031297]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; 5'-3' DNA/RNA helicase activity [GO:0033678]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein-DNA complex displacement activity [GO:0061995]; DNA/DNA annealing activity [GO:1990814]; flap-structured DNA binding [GO:0070336]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex unwinding activity [GO:0160225]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]	chromatin [GO:0000785]; chromosome, telomeric repeat region [GO:0140445]; mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; nuclear replisome [GO:0043601]; nucleolus [GO:0005730]; nucleus [GO:0005634]; rDNA heterochromatin [GO:0033553]; site of double-strand break [GO:0035861]	GO:0000723; GO:0000785; GO:0003697; GO:0003723; GO:0005524; GO:0005634; GO:0005730; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0017116; GO:0031297; GO:0033553; GO:0033678; GO:0035861; GO:0043139; GO:0043504; GO:0043596; GO:0043601; GO:0051880; GO:0061995; GO:0070336; GO:0071932; GO:0140445; GO:0160225; GO:1902983; GO:1903469; GO:1990426; GO:1990814
GN004366	GN004366.1	Q5U258	38.9	334	408	443	2.67e-78	251	GCNT3_XENLA	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M)	Xenopus laevis (African clawed frog)		acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0047225]; acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]	Golgi membrane [GO:0000139]	GO:0000139; GO:0003829; GO:0008109; GO:0008375; GO:0047225
GN004367	GN004367.1	Q96ES7	67.2	293	311	293	1.63e-134	386	SGF29_HUMAN	SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29)	Homo sapiens (Human)	establishment of protein localization to chromatin [GO:0071169]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]; response to endoplasmic reticulum stress [GO:0034976]; transcription initiation-coupled chromatin remodeling [GO:0045815]	histone H3K36me3 reader activity [GO:0140003]; histone H3K4me3 reader activity [GO:0140002]; methylation-dependent protein binding [GO:0140034]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461]	GO:0000122; GO:0000124; GO:0005634; GO:0005654; GO:0005730; GO:0006282; GO:0006355; GO:0006357; GO:0034976; GO:0043484; GO:0045815; GO:0045893; GO:0045995; GO:0051302; GO:0051726; GO:0070461; GO:0071169; GO:0072686; GO:0090043; GO:0140002; GO:0140003; GO:0140034; GO:0140672
GN004368	GN004368.1	Q569K6	25.3	677	808	752	7.69e-35	145	CC157_HUMAN	Coiled-coil domain-containing protein 157	Homo sapiens (Human)				
GN004369	GN004369.1	Q7K556	62.1	58	64	475	7.28e-19	81.3	TTD14_DROME	TRPL translocation defect protein 14	Drosophila melanogaster (Fruit fly)	photoreceptor cell maintenance [GO:0045494]	GTP binding [GO:0005525]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol binding [GO:0035091]	cytosol [GO:0005829]	GO:0005525; GO:0005829; GO:0035091; GO:0045494; GO:0070300
GN004372	GN004372.1	Q9CXW2	36.3	248	365	359	1.58e-41	152	RT22_MOUSE	Small ribosomal subunit protein mS22 (28S ribosomal protein S22, mitochondrial) (MRP-S22) (S22mt)	Mus musculus (Mouse)	mitochondrial translation [GO:0032543]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005763; GO:0032543
GN004373	GN004373.1	Q9VQ37	48.2	388	365	365	1.19e-103	312	RIM2_DROME	Mitochondrial carrier protein Rim2	Drosophila melanogaster (Fruit fly)	deoxynucleotide transport [GO:0030302]; pyrimidine nucleotide import into mitochondrion [GO:1990519]	pyrimidine nucleotide transmembrane transporter activity [GO:0015218]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0015218; GO:0030302; GO:1990519
GN004376	GN004376.1	Q9WV50	76.4	106	108	180	1.69e-57	178	NIP7_RAT	60S ribosome subunit biogenesis protein NIP7 homolog (Nucleolar pre-rRNA processing protein NIP7) (PEachy) (kDa93)	Rattus norvegicus (Rat)	ribosomal large subunit biogenesis [GO:0042273]; ribosome assembly [GO:0042255]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]	GO:0003723; GO:0005730; GO:0030687; GO:0042255; GO:0042273
GN004395	GN004395.1	P86952	48.4	128	303	456	2.16e-27	114	TYRO_PINMA	Tyrosinase-like protein (Tyrosinase-2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN004400	GN004400.1	P31508	84.5	71	400	81	1.19e-18	83.2	ESCA_APIME	Escargot/snail protein homolog	Apis mellifera (Honeybee)		DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634
GN004405	GN004405.1	Q6YHK3	34.8	1475	1444	1445	2.00e-269	813	CD109_HUMAN	CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)	Homo sapiens (Human)	negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]	endopeptidase inhibitor activity [GO:0004866]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	GO:0004866; GO:0005576; GO:0005886; GO:0009986; GO:0030512; GO:0031092; GO:0061045
GN004406	GN004406.1	Q96NW4	25.3	813	1024	1050	1.19e-53	207	ANR27_HUMAN	Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein)	Homo sapiens (Human)	early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; endosome to melanosome transport [GO:0035646]; negative regulation of SNARE complex assembly [GO:0035544]; neuron projection morphogenesis [GO:0048812]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of neuron projection development [GO:0010976]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]	cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; tubular endosome [GO:0097422]	GO:0000149; GO:0005085; GO:0005764; GO:0005769; GO:0005770; GO:0005829; GO:0005886; GO:0010976; GO:0016020; GO:0030133; GO:0030659; GO:0031267; GO:0032456; GO:0035544; GO:0035646; GO:0042470; GO:0043005; GO:0045022; GO:0048812; GO:0050775; GO:0097422
GN004410	GN004410.1	Q9Y5B0	38.5	564	710	961	2.59e-59	219	CTDP1_HUMAN	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase)	Homo sapiens (Human)	exit from mitosis [GO:0010458]; host-mediated activation of viral transcription [GO:0043923]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; protein dephosphorylation [GO:0006470]; transcription elongation by RNA polymerase II [GO:0006368]	phosphoprotein phosphatase activity [GO:0004721]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; Tat protein binding [GO:0030957]; TFIIF-class transcription factor complex binding [GO:0001096]	centrosome [GO:0005813]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]	GO:0000922; GO:0001096; GO:0004721; GO:0005634; GO:0005654; GO:0005813; GO:0005819; GO:0006368; GO:0006470; GO:0008420; GO:0010458; GO:0030496; GO:0030957; GO:0032991; GO:0043923; GO:0051233; GO:0061052
GN004411	GN004411.1	Q8VYX1	53.1	486	489	498	1.66e-171	495	PEAM1_WHEAT	Phosphoethanolamine N-methyltransferase 1 (TaPEAMT1) (EC 2.1.1.103) (Phosphoethanolamine N-methyltransferase) (WPEAMT)	Triticum aestivum (Wheat)	phosphatidylcholine biosynthetic process [GO:0006656]	phosphoethanolamine N-methyltransferase activity [GO:0000234]		GO:0000234; GO:0006656
GN004412	GN004412.1	Q8JZL3	38.5	182	413	224	8.23e-26	107	THTPA_MOUSE	Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28)	Mus musculus (Mouse)	dephosphorylation [GO:0016311]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine diphosphate metabolic process [GO:0042357]; thiamine metabolic process [GO:0006772]	magnesium ion binding [GO:0000287]; thiamine triphosphate phosphatase activity [GO:0050333]	cytosol [GO:0005829]	GO:0000287; GO:0005829; GO:0006772; GO:0009229; GO:0016311; GO:0042357; GO:0050333
GN004414	GN004414.1	P26270	82.2	275	327	338	6.01e-166	468	PSMD7_DROME	26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Proteasome subunit p39B) (Proteasome subunit p40) (Protein Mov34)	Drosophila melanogaster (Fruit fly)	proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]		cytosol [GO:0005829]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]	GO:0000502; GO:0005654; GO:0005829; GO:0005838; GO:0008541; GO:0010498; GO:0030425; GO:0043161
GN004415	GN004415.1	Q6PBJ2	98.0	102	103	192	3.88e-69	207	CFA20_DANRE	Cilia- and flagella-associated protein 20	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; determination of heart left/right asymmetry [GO:0061371]; notochord morphogenesis [GO:0048570]; positive regulation of cell motility [GO:2000147]; positive regulation of feeding behavior [GO:2000253]; protein polyglutamylation [GO:0018095]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of heart looping [GO:1901207]; regulation of somitogenesis [GO:0014807]; retina homeostasis [GO:0001895]; specification of axis polarity [GO:0065001]		axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; motile cilium [GO:0031514]; nucleus [GO:0005634]	GO:0001895; GO:0005634; GO:0005814; GO:0005879; GO:0005929; GO:0014807; GO:0018095; GO:0031514; GO:0036064; GO:0048570; GO:0060271; GO:0060296; GO:0061371; GO:0065001; GO:1901207; GO:2000147; GO:2000253
GN004416	GN004416.1	Q9H0I3	44.9	245	278	377	2.38e-46	162	CF263_HUMAN	Cilia- and flagella-associated protein 263	Homo sapiens (Human)	cilium assembly [GO:0060271]		axoneme [GO:0005930]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; protein-containing complex [GO:0032991]	GO:0005930; GO:0032991; GO:0034451; GO:0036064; GO:0060271
GN004417	GN004417.1	Q9XS59	39.8	334	391	729	8.42e-73	244	S6A15_BOVIN	Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Solute carrier family 6 member 15) (Transporter v7-3)	Bos taurus (Bovine)	L-leucine transport [GO:0015820]; neutral amino acid transport [GO:0015804]; proline transport [GO:0015824]; sodium ion transmembrane transport [GO:0035725]	alanine:sodium symporter activity [GO:0015655]; branched-chain amino acid:sodium symporter activity [GO:0015657]; L-asparagine:sodium symporter activity [GO:0140901]; neutral L-amino acid:sodium symporter activity [GO:0005295]; proline:sodium symporter activity [GO:0005298]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005295; GO:0005298; GO:0005886; GO:0015655; GO:0015657; GO:0015804; GO:0015820; GO:0015824; GO:0016020; GO:0035725; GO:0140901
GN004418	GN004418.1	Q9NP91	54.7	148	165	592	1.38e-50	173	S6A20_HUMAN	Sodium- and chloride-dependent transporter XTRP3 (Sodium/imino-acid transporter 1) (Solute carrier family 6 member 20) (Transporter rB21A homolog)	Homo sapiens (Human)	amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; amino-acid betaine transport [GO:0015838]; glycine import across plasma membrane [GO:1903804]; glycine transport [GO:0015816]; L-isoleucine import across plasma membrane [GO:1903806]; L-proline import across plasma membrane [GO:1904271]; neurotransmitter transport [GO:0006836]; proline import across plasma membrane [GO:1905647]; proline transport [GO:0015824]; sodium ion transmembrane transport [GO:0035725]; transport across blood-brain barrier [GO:0150104]	amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; glycine transmembrane transporter activity [GO:0015187]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-proline transmembrane transporter activity [GO:0015193]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; proline:sodium symporter activity [GO:0005298]; solute:sodium symporter activity [GO:0015370]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0005298; GO:0005886; GO:0006836; GO:0006865; GO:0015171; GO:0015175; GO:0015187; GO:0015188; GO:0015193; GO:0015199; GO:0015370; GO:0015816; GO:0015824; GO:0015838; GO:0016324; GO:0035725; GO:0045211; GO:0089718; GO:0150104; GO:1903804; GO:1903806; GO:1904271; GO:1905647
GN004419	GN004419.1	Q0D2D2	44.4	81	182	551	1.03e-11	65.9	FBX31_XENTR	F-box only protein 31	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; cellular response to oxidative stress [GO:0034599]; DNA damage response [GO:0006974]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005737; GO:0006974; GO:0016567; GO:0019005; GO:0031145; GO:0031146; GO:0031571; GO:0034599; GO:0043161; GO:1990756
GN004427	GN004427.1	Q5RHR6	40.6	1345	1338	1298	0.0	968	BROMI_DANRE	Protein broad-minded (TBC1 domain family member 32)	Danio rerio (Zebrafish) (Brachydanio rerio)	axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; non-motile cilium assembly [GO:1905515]; retinal pigment epithelium development [GO:0003406]		cilium [GO:0005929]; cytoplasm [GO:0005737]	GO:0003406; GO:0005737; GO:0005929; GO:0035082; GO:0060271; GO:1905515
GN004430	GN004430.1	A4FUZ6	38.8	80	82	418	1.04e-12	64.7	HSDL2_BOVIN	Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-)	Bos taurus (Bovine)	cholesterol homeostasis [GO:0042632]		mitochondrion [GO:0005739]; peroxisome [GO:0005777]	GO:0005739; GO:0005777; GO:0042632
GN004432	GN004432.1	Q6P3Z3	50.0	62	223	569	1.94e-11	66.2	THAP4_MOUSE	Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric nitrobindin) (Nb(III)) (THAP domain-containing protein 4)	Mus musculus (Mouse)	cellular response to reactive nitrogen species [GO:1902170]; nitrate metabolic process [GO:0042126]	heme binding [GO:0020037]; identical protein binding [GO:0042802]; nitric oxide binding [GO:0070026]; peroxynitrite isomerase activity [GO:0062213]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0020037; GO:0042126; GO:0042802; GO:0062213; GO:0070026; GO:1902170
GN004433	GN004433.1	D3YXG0	50.0	162	347	5634	4.59e-50	183	HMCN1_MOUSE	Hemicentin-1 (Fibulin-6) (FIBL-6)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]; response to bacterium [GO:0009617]	calcium ion binding [GO:0005509]; cell adhesion mediator activity [GO:0098631]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; muscle tendon junction [GO:0005927]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005509; GO:0005576; GO:0005604; GO:0005737; GO:0005886; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0009617; GO:0030036; GO:0030054; GO:0031012; GO:0032154; GO:0070161; GO:0071711; GO:0098631; GO:0140144
GN004435	GN004435.1	Q9GUM2	39.9	248	320	383	1.46e-57	193	BRE4_CAEEL	Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.244) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT) (UDP-GalNAc:Glc-NAcbeta-R beta1,4-N-acetylgalactosaminyltransferase) (Cebeta4GalNAcT)	Caenorhabditis elegans	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; positive regulation of Notch signaling pathway [GO:0045747]; response to toxic substance [GO:0009636]	acetylgalactosaminyltransferase activity [GO:0008376]; N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0005794; GO:0005975; GO:0006688; GO:0008376; GO:0009101; GO:0009636; GO:0016020; GO:0033842; GO:0045747
GN004437	GN004437.1	O35929	35.8	179	286	297	6.32e-18	85.1	REM1_MOUSE	GTP-binding protein REM 1 (Rad and Gem-like GTP-binding protein 1)	Mus musculus (Mouse)	negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; regulation of skeletal muscle contraction by calcium ion signaling [GO:0014722]	calcium channel regulator activity [GO:0005246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; transmembrane transporter binding [GO:0044325]	I band [GO:0031674]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]	GO:0003924; GO:0005246; GO:0005525; GO:0005886; GO:0014722; GO:0030315; GO:0031674; GO:0044325; GO:1904878
GN004440	GN004440.1	P55041	30.6	206	325	295	1.52e-21	95.9	GEM_MOUSE	GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR)	Mus musculus (Mouse)	chromosome organization [GO:0051276]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]	calcium channel regulator activity [GO:0005246]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	cytoplasmic side of plasma membrane [GO:0009898]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle midzone [GO:0051233]	GO:0000278; GO:0000287; GO:0003924; GO:0005246; GO:0005525; GO:0005634; GO:0005886; GO:0009898; GO:0019003; GO:0030496; GO:0051233; GO:0051276; GO:0051310; GO:0072686
GN004443	GN004443.1	Q96PX9	33.8	1164	1318	1627	4.07e-149	495	PKH4B_HUMAN	Pleckstrin homology domain-containing family G member 4B (PH domain-containing family G member 4B)	Homo sapiens (Human)	axon guidance [GO:0007411]; cell-cell adhesion [GO:0098609]; regulation of small GTPase mediated signal transduction [GO:0051056]	guanyl-nucleotide exchange factor activity [GO:0005085]	anchoring junction [GO:0070161]; basal plasma membrane [GO:0009925]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005085; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0007411; GO:0009925; GO:0019898; GO:0051056; GO:0070161; GO:0098609
GN004445	GN004445.1	Q9P2D1	58.2	1119	1681	2997	0.0	1217	CHD7_HUMAN	ATP-dependent chromatin remodeler CHD7 (EC 3.6.4.-) (Chromo domain-containing protein 7) (CHD-7)	Homo sapiens (Human)	central nervous system development [GO:0007417]; chordate embryonic development [GO:0043009]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; cranial nerve development [GO:0021545]; face development [GO:0060324]; genitalia development [GO:0048806]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; limb development [GO:0060173]; nose development [GO:0043584]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of growth hormone secretion [GO:0060123]; retina development in camera-type eye [GO:0060041]; secondary palate development [GO:0062009]; skeletal system development [GO:0001501]; T cell differentiation [GO:0030217]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0001501; GO:0001701; GO:0003007; GO:0003677; GO:0003682; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006338; GO:0006355; GO:0007417; GO:0010468; GO:0016887; GO:0021545; GO:0030217; GO:0042393; GO:0042472; GO:0043009; GO:0043584; GO:0048806; GO:0050890; GO:0060041; GO:0060123; GO:0060173; GO:0060324; GO:0062009; GO:0140658; GO:1990841
GN004449	GN004449.1	Q8TDB6	46.9	207	1546	740	4.38e-50	194	DTX3L_HUMAN	E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)	Homo sapiens (Human)	DNA damage checkpoint signaling [GO:0000077]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; endosome to lysosome transport [GO:0008333]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; Notch signaling pathway [GO:0007219]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor catabolic process [GO:2000646]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone H4K91 ubiquitin ligase activity [GO:0141000]; histone ubiquitin ligase activity [GO:0140852]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]; STAT family protein binding [GO:0097677]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000077; GO:0002230; GO:0004842; GO:0004857; GO:0005634; GO:0005654; GO:0005737; GO:0005764; GO:0005765; GO:0005829; GO:0006302; GO:0006511; GO:0007219; GO:0008333; GO:0016567; GO:0019899; GO:0031901; GO:0032092; GO:0032991; GO:0035563; GO:0042393; GO:0044389; GO:0045893; GO:0051444; GO:0051865; GO:0061630; GO:0070936; GO:0097677; GO:0140768; GO:0140852; GO:0140861; GO:0141000; GO:1900182; GO:1902966; GO:2000646
GN004451	GN004451.1	Q567I9	71.5	214	215	214	7.44e-111	319	CB5D1_DANRE	Cytochrome b5 domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium movement [GO:0003341]; regulation of cilium beat frequency [GO:0003356]		axoneme [GO:0005930]	GO:0003341; GO:0003356; GO:0005930
GN004454	GN004454.1	P47743	26.9	453	1184	908	2.28e-32	140	GRM8_MOUSE	Metabotropic glutamate receptor 8 (mGluR8)	Mus musculus (Mouse)	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic transmission, glutamatergic [GO:0035249]	G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]	GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; presynaptic membrane [GO:0042734]	GO:0001642; GO:0004930; GO:0005886; GO:0007193; GO:0007196; GO:0007216; GO:0007268; GO:0008066; GO:0035249; GO:0042734; GO:0043025; GO:0046928; GO:0048787; GO:0050966; GO:0051966; GO:0098978; GO:0098982; GO:0099171
GN004455	GN004455.1	P97772	32.1	496	1334	1199	1.88e-53	209	GRM1_MOUSE	Metabotropic glutamate receptor 1 (mGluR1)	Mus musculus (Mouse)	calcium-mediated signaling [GO:0019722]; cellular response to electrical stimulus [GO:0071257]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; G protein-coupled receptor signaling pathway [GO:0007186]; L-glutamate import across plasma membrane [GO:0098712]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of MAPK cascade [GO:0043410]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]; synaptic signaling via neuropeptide [GO:0099538]	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled neurotransmitter receptor activity [GO:0099528]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; nuclear estrogen receptor binding [GO:0030331]; PLC activating G protein-coupled glutamate receptor activity [GO:0001639]	axon [GO:0030424]; dendriole [GO:0044293]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; G protein-coupled receptor dimeric complex [GO:0038037]; G protein-coupled receptor homodimeric complex [GO:0038038]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0001639; GO:0001640; GO:0005634; GO:0005886; GO:0007186; GO:0007200; GO:0007206; GO:0007216; GO:0007268; GO:0007626; GO:0008066; GO:0014069; GO:0019233; GO:0019722; GO:0030331; GO:0030424; GO:0030425; GO:0038037; GO:0038038; GO:0042734; GO:0043005; GO:0043025; GO:0043197; GO:0043410; GO:0044293; GO:0044309; GO:0045211; GO:0051930; GO:0051966; GO:0071257; GO:0098685; GO:0098712; GO:0098839; GO:0098978; GO:0099528; GO:0099530; GO:0099538
GN004456	GN004456.1	P54245	27.8	151	165	635	1.01e-18	85.5	LGC4_CAEEL	Ligand-gated ion channel 4	Caenorhabditis elegans	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:1902495
GN004457	GN004457.1	O93603	46.3	175	227	395	2.37e-43	153	TRHR_CHICK	Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor)	Gallus gallus (Chicken)	phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	thyrotropin-releasing hormone receptor activity [GO:0004997]	plasma membrane [GO:0005886]	GO:0004997; GO:0005886; GO:0007200
GN004458	GN004458.1	Q9QXA6	52.2	475	560	487	2.30e-169	492	BAT1_MOUSE	b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)	Mus musculus (Mouse)	amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; L-cystine transport [GO:0015811]; neutral amino acid transport [GO:0015804]	amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; broad specificity neutral L-amino acid:basic L-amino acid antiporter activity [GO:0180009]; L-cystine transmembrane transporter activity [GO:0015184]; L-lysine:L-arginine antiporter activity [GO:0106439]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; protein heterodimerization activity [GO:0046982]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]	GO:0003333; GO:0005886; GO:0006865; GO:0015171; GO:0015175; GO:0015184; GO:0015297; GO:0015804; GO:0015811; GO:0016324; GO:0031526; GO:0042605; GO:0046982; GO:0106439; GO:0180009; GO:1902495
GN004459	GN004459.1	P08953	21.8	611	734	1097	6.33e-10	66.6	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN004461	GN004461.1	Q80V03	47.9	541	608	582	1.74e-160	474	ADCK5_MOUSE	Uncharacterized aarF domain-containing protein kinase 5 (EC 2.7.11.-)	Mus musculus (Mouse)			membrane [GO:0016020]; mitochondrion [GO:0005739]	GO:0005739; GO:0016020
GN004462	GN004462.1	P12815	66.5	167	190	191	1.50e-82	245	PDCD6_MOUSE	Programmed cell death protein 6 (ALG-257) (Apoptosis-linked gene 2 protein) (ALG-2) (PMP41)	Mus musculus (Mouse)	apoptotic process [GO:0006915]; cellular response to heat [GO:0034605]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; protein-membrane adaptor activity [GO:0043495]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	COPII vesicle coat [GO:0030127]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0000287; GO:0001938; GO:0005509; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005783; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0006915; GO:0010595; GO:0014029; GO:0014032; GO:0030127; GO:0030674; GO:0030948; GO:0031410; GO:0031463; GO:0032007; GO:0034605; GO:0036324; GO:0042802; GO:0042803; GO:0043065; GO:0043495; GO:0045766; GO:0046982; GO:0046983; GO:0048208; GO:0048306; GO:0048471; GO:0051592; GO:0051898; GO:0070971; GO:1902527; GO:1990756
GN004465	GN004465.1	Q9UBE8	82.4	370	459	527	3.25e-229	641	NLK_HUMAN	Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1)	Homo sapiens (Human)	cellular response to osmotic stress [GO:0071470]; intracellular signal transduction [GO:0035556]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of Wnt signaling pathway [GO:0030178]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of DNA-templated transcription [GO:0006355]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]	ATP binding [GO:0005524]; DNA-binding transcription factor binding [GO:0140297]; magnesium ion binding [GO:0000287]; MAP kinase activity [GO:0004707]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; SH2 domain binding [GO:0042169]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0004672; GO:0004674; GO:0004707; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006355; GO:0006468; GO:0007179; GO:0007223; GO:0018107; GO:0030178; GO:0031625; GO:0035556; GO:0042169; GO:0050821; GO:0071470; GO:0106310; GO:0140297; GO:1904262; GO:1904894
GN004466	GN004466.1	P18887	39.2	663	616	633	7.04e-131	400	XRCC1_HUMAN	DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)	Homo sapiens (Human)	base-excision repair [GO:0006284]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of protein ADP-ribosylation [GO:0010836]; regulation of base-excision repair [GO:1905051]; regulation of DNA repair [GO:0006282]; response to hydroperoxide [GO:0033194]; single strand break repair [GO:0000012]; telomeric DNA-containing double minutes formation [GO:0061819]	3' overhang single-stranded DNA endonuclease activity [GO:1990599]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; enzyme binding [GO:0019899]; oxidized DNA binding [GO:0032356]; poly-ADP-D-ribose binding [GO:0072572]; single-strand break-containing DNA binding [GO:1990165]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; DNA ligase III-XRCC1 complex [GO:0070421]; ERCC4-ERCC1 complex [GO:0070522]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0000012; GO:0000781; GO:0000785; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0006282; GO:0006284; GO:0006302; GO:0006303; GO:0010836; GO:0019899; GO:0032356; GO:0033194; GO:0061819; GO:0070421; GO:0070522; GO:0072572; GO:0090734; GO:0160002; GO:1905051; GO:1905765; GO:1990165; GO:1990599
GN004467	GN004467.1	Q5ZMA2	69.5	82	98	505	4.34e-33	122	PRP19_CHICK	Pre-mRNA-processing factor 19 (EC 2.3.2.27) (PRP19/PSO4 homolog) (RING-type E3 ubiquitin transferase PRP19)	Gallus gallus (Chicken)	mRNA splicing, via spliceosome [GO:0000398]; protein K63-linked ubiquitination [GO:0070534]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spindle [GO:0005819]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0000398; GO:0000974; GO:0005634; GO:0005654; GO:0005737; GO:0005811; GO:0005819; GO:0061630; GO:0070534; GO:0071006
GN004468	GN004468.1	Q99KP6	61.5	278	330	504	1.06e-103	316	PRP19_MOUSE	Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)	Mus musculus (Mouse)	DNA damage checkpoint signaling [GO:0000077]; double-strand break repair via nonhomologous end joining [GO:0006303]; inner cell mass cell proliferation [GO:0001833]; intracellular protein localization [GO:0008104]; lipid biosynthetic process [GO:0008610]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of neuron differentiation [GO:0045666]; proteasomal protein catabolic process [GO:0010498]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of neuron differentiation [GO:0045664]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; DNA replication factor A complex [GO:0005662]; lipid droplet [GO:0005811]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; site of double-strand break [GO:0035861]; spindle [GO:0005819]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000077; GO:0000209; GO:0000244; GO:0000245; GO:0000398; GO:0000974; GO:0001833; GO:0005634; GO:0005662; GO:0005681; GO:0005737; GO:0005811; GO:0005819; GO:0006303; GO:0008104; GO:0008610; GO:0010498; GO:0016607; GO:0034450; GO:0035861; GO:0042802; GO:0045664; GO:0045665; GO:0045666; GO:0048026; GO:0048711; GO:0061630; GO:0070534; GO:0071006; GO:0071007; GO:0071013; GO:0071014; GO:0071020
GN004469	GN004469.1	Q8N9F7	59.8	92	102	314	9.50e-34	121	GDPD1_HUMAN	Lysophospholipase D GDPD1 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 4) (Glycerophosphodiester phosphodiesterase domain-containing protein 1)	Homo sapiens (Human)	glycerophospholipid catabolic process [GO:0046475]; N-acylethanolamine metabolic process [GO:0070291]	phosphatidylcholine lysophospholipase A1 activity [GO:0004622]; phosphoric diester hydrolase activity [GO:0008081]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	GO:0004622; GO:0005737; GO:0005783; GO:0005789; GO:0008081; GO:0016020; GO:0046475; GO:0048471; GO:0070291
GN004471	GN004471.1	Q9BXJ4	30.5	128	127	246	8.30e-10	57.8	C1QT3_HUMAN	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	Homo sapiens (Human)	fat cell differentiation [GO:0045444]; intracellular triglyceride homeostasis [GO:0035356]; maintenance of synapse structure [GO:0099558]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001819; GO:0010629; GO:0016020; GO:0032715; GO:0032991; GO:0035356; GO:0042802; GO:0043083; GO:0045202; GO:0045444; GO:0045721; GO:0050728; GO:0070062; GO:0070165; GO:0071638; GO:0099550; GO:0099558; GO:1901223
GN004474	GN004474.1	Q9CUX1	45.2	62	94	758	2.54e-10	58.5	P52K_MOUSE	52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (THAP domain-containing protein 0) (THAP domain-containing protein 12)	Mus musculus (Mouse)		protein dimerization activity [GO:0046983]	nucleus [GO:0005634]	GO:0005634; GO:0046983
GN004476	GN004476.1	Q9CR14	42.5	374	373	375	1.78e-115	343	FANCL_MOUSE	E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia group L protein homolog) (Proliferation of germ cells protein) (RING-type E3 ubiquitin transferase FANCL)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; gamete generation [GO:0007276]; interstrand cross-link repair [GO:0036297]; protein monoubiquitination [GO:0006513]; regulation of cell population proliferation [GO:0042127]; single fertilization [GO:0007338]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; Fanconi anaemia nuclear complex [GO:0043240]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]	GO:0000785; GO:0004842; GO:0005634; GO:0005635; GO:0005737; GO:0006281; GO:0006513; GO:0006974; GO:0007276; GO:0007338; GO:0016604; GO:0031625; GO:0036297; GO:0042127; GO:0043240; GO:0061630
GN004480	GN004480.1	B3DLE8	30.0	213	218	611	4.51e-18	85.5	SPDLY_XENTR	Protein Spindly (Coiled-coil domain-containing protein 99) (Spindle apparatus coiled-coil domain-containing protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	establishment of mitotic spindle orientation [GO:0000132]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]	kinetochore binding [GO:0043515]	nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922]	GO:0000132; GO:0000922; GO:0000940; GO:0005634; GO:0007080; GO:0007094; GO:0034501; GO:0043515
GN004482	GN004482.1	A1ZA47	46.2	91	137	2194	7.94e-21	90.5	ZASP_DROME	PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein)	Drosophila melanogaster (Fruit fly)	actin cytoskeleton organization [GO:0030036]; muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; regulation of cell-matrix adhesion [GO:0001952]	actin binding [GO:0003779]; actinin binding [GO:0042805]; muscle alpha-actinin binding [GO:0051371]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; basolateral plasma membrane [GO:0016323]; cell leading edge [GO:0031252]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; muscle tendon junction [GO:0005927]; stress fiber [GO:0001725]; Z disc [GO:0030018]; zonula adherens [GO:0005915]	GO:0001725; GO:0001952; GO:0003779; GO:0005912; GO:0005915; GO:0005925; GO:0005927; GO:0015629; GO:0016323; GO:0030018; GO:0030036; GO:0030239; GO:0031252; GO:0031941; GO:0042805; GO:0045177; GO:0045178; GO:0051371; GO:0061061
GN004484	GN004484.1	Q19187	24.9	543	992	1679	7.32e-48	190	GCY12_CAEEL	Receptor-type guanylate cyclase gcy-12 (EC 4.6.1.2)	Caenorhabditis elegans	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; negative regulation of dauer larval development [GO:0061067]; negative regulation of multicellular organism growth [GO:0040015]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of locomotion involved in locomotory behavior [GO:0090325]; regulation of multicellular organism growth [GO:0040014]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	cilium [GO:0005929]; dendrite [GO:0030425]; non-motile cilium [GO:0097730]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0005929; GO:0006182; GO:0007168; GO:0030425; GO:0035556; GO:0040014; GO:0040015; GO:0043204; GO:0061067; GO:0090325; GO:0097730
GN004486	GN004486.1	P78364	42.0	288	902	1004	3.45e-41	167	PHC1_HUMAN	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]	GO:0000785; GO:0001739; GO:0003682; GO:0005634; GO:0005654; GO:0006338; GO:0008270; GO:0016604; GO:0031507; GO:0031519; GO:0035102; GO:0042393; GO:0045892
GN004490	GN004490.1	Q9I8C7	32.5	317	475	452	3.53e-63	214	ACH10_CHICK	Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0050910; GO:0097060; GO:1902495
GN004491	GN004491.1	Q28IA3	44.2	278	340	292	5.50e-80	248	AKTIP_XENTR	AKT-interacting protein (Fused toes protein homolog)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]		FHF complex [GO:0070695]; plasma membrane [GO:0005886]	GO:0005886; GO:0007032; GO:0007040; GO:0008333; GO:0045022; GO:0070695
GN004492	GN004492.1	Q9I8C7	33.2	304	441	452	6.68e-60	205	ACH10_CHICK	Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0050910; GO:0097060; GO:1902495
GN004493	GN004493.1	A4IFH5	65.2	305	339	496	3.73e-137	401	ALAT1_BOVIN	Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase) (Glutamate pyruvate transaminase 1) (GPT-1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1)	Bos taurus (Bovine)	L-alanine catabolic process [GO:0042853]	L-alanine:2-oxoglutarate transaminase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]	GO:0004021; GO:0005737; GO:0030170; GO:0042853
GN004494	GN004494.1	Q6NYL5	61.6	138	139	549	6.39e-54	180	ALAT2_DANRE	Alanine aminotransferase 2-like (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	2-oxoglutarate metabolic process [GO:0006103]; L-alanine catabolic process [GO:0042853]	L-alanine:2-oxoglutarate transaminase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]	GO:0004021; GO:0005737; GO:0006103; GO:0030170; GO:0042853
GN004499	GN004499.1	Q58DN7	45.7	116	122	586	1.37e-28	111	ACSF3_BOVIN	Malonate--CoA ligase ACSF3, mitochondrial (EC 6.2.1.76) (Acyl-CoA synthetase family member 3)	Bos taurus (Bovine)	fatty acid biosynthetic process [GO:0006633]; malonate catabolic process [GO:0090410]	malonyl-CoA synthetase activity [GO:0090409]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	mitochondrion [GO:0005739]	GO:0005739; GO:0006633; GO:0031957; GO:0090409; GO:0090410
GN004500	GN004500.1	Q6GLK6	49.6	129	129	578	1.00e-29	115	ACSF3_XENLA	Malonate--CoA ligase ACSF3, mitochondrial (EC 6.2.1.76) (Acyl-CoA synthetase family member 3)	Xenopus laevis (African clawed frog)	fatty acid biosynthetic process [GO:0006633]; malonate catabolic process [GO:0090410]	malonyl-CoA synthetase activity [GO:0090409]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	mitochondrion [GO:0005739]	GO:0005739; GO:0006633; GO:0031956; GO:0031957; GO:0090409; GO:0090410
GN004501	GN004501.1	Q6GLK6	30.4	171	245	578	2.85e-17	84.0	ACSF3_XENLA	Malonate--CoA ligase ACSF3, mitochondrial (EC 6.2.1.76) (Acyl-CoA synthetase family member 3)	Xenopus laevis (African clawed frog)	fatty acid biosynthetic process [GO:0006633]; malonate catabolic process [GO:0090410]	malonyl-CoA synthetase activity [GO:0090409]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	mitochondrion [GO:0005739]	GO:0005739; GO:0006633; GO:0031956; GO:0031957; GO:0090409; GO:0090410
GN004506	GN004506.1	Q9DAM1	51.3	351	381	415	2.49e-32	129	LRC34_MOUSE	Leucine-rich repeat-containing protein 34	Mus musculus (Mouse)	gene expression [GO:0010467]; telomere maintenance [GO:0000723]		cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0000723; GO:0005634; GO:0005730; GO:0005737; GO:0010467
GN004507	GN004507.1	D3YZI9	33.1	121	212	523	2.55e-09	59.7	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN004508	GN004508.1	P97329	42.1	454	800	887	2.03e-82	285	KI20A_MOUSE	Kinesin-like protein KIF20A (Kinesin-like protein 174) (Rab6-interacting kinesin-like protein) (Rabkinesin-6)	Mus musculus (Mouse)	microtubule bundle formation [GO:0001578]; microtubule-based movement [GO:0007018]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; regulation of cytokinesis [GO:0032465]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; protein kinase binding [GO:0019901]	cleavage furrow [GO:0032154]; Golgi apparatus [GO:0005794]; intercellular bridge [GO:0045171]; kinesin complex [GO:0005871]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0000281; GO:0001578; GO:0003777; GO:0005524; GO:0005634; GO:0005654; GO:0005794; GO:0005819; GO:0005871; GO:0007018; GO:0008017; GO:0019901; GO:0030496; GO:0032154; GO:0032465; GO:0045171; GO:0061952; GO:0072686
GN004511	GN004511.1	Q6NRV0	30.1	176	183	464	1.85e-13	70.9	TRAIP_XENLA	E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (TRAF-interacting protein)	Xenopus laevis (African clawed frog)	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; interstrand cross-link repair [GO:0036297]; protein ubiquitination [GO:0016567]; protein-DNA covalent cross-linking repair [GO:0106300]; replication fork processing [GO:0031297]	MCM complex binding [GO:1904931]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0004842; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006281; GO:0006974; GO:0016567; GO:0031297; GO:0036297; GO:0061630; GO:0090734; GO:0106300; GO:1904931
GN004512	GN004512.1	O00411	36.8	1036	1288	1230	3.23e-200	621	RPOM_HUMAN	DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)	Homo sapiens (Human)	mitochondrial DNA replication [GO:0006264]; mitochondrial transcription [GO:0006390]; transcription initiation at mitochondrial promoter [GO:0006391]	3'-5'-RNA exonuclease activity [GO:0000175]; DNA-directed RNA polymerase activity [GO:0003899]; mitochondrial promoter sequence-specific DNA binding [GO:0001018]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]	mitochondrial DNA-directed RNA polymerase complex [GO:0034245]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	GO:0000175; GO:0001018; GO:0003723; GO:0003899; GO:0005739; GO:0005759; GO:0006264; GO:0006390; GO:0006391; GO:0032991; GO:0034245; GO:0042645; GO:0043565
GN004514	GN004514.1	O14734	46.4	263	328	319	1.51e-80	250	ACOT8_HUMAN	Acyl-coenzyme A thioesterase 8 (Acyl-CoA thioesterase 8) (EC 3.1.2.1) (EC 3.1.2.11) (EC 3.1.2.2) (EC 3.1.2.3) (EC 3.1.2.5) (Choloyl-coenzyme A thioesterase) (EC 3.1.2.27) (HIV-Nef-associated acyl-CoA thioesterase) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-CoA thioesterase 1) (Thioesterase II) (hACTE-III) (hACTEIII) (hTE)	Homo sapiens (Human)	acyl-CoA metabolic process [GO:0006637]; alpha-linolenic acid metabolic process [GO:0036109]; bile acid biosynthetic process [GO:0006699]; dicarboxylic acid catabolic process [GO:0043649]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid biosynthetic process [GO:0006633]; fatty acid catabolic process [GO:0009062]; negative regulation of glycoprotein biosynthetic process [GO:0010561]; peroxisome fission [GO:0016559]	acetoacetyl-CoA hydrolase activity [GO:0047603]; acetyl-CoA hydrolase activity [GO:0003986]; acyl-CoA hydrolase activity [GO:0016289]; choloyl-CoA hydrolase activity [GO:0033882]; fatty acyl-CoA hydrolase activity [GO:0047617]; hydroxymethylglutaryl-CoA hydrolase activity [GO:0047994]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; medium-chain fatty acyl-CoA hydrolase activity [GO:0052815]; short-chain fatty acyl-CoA hydrolase activity [GO:0141126]; succinyl-CoA hydrolase activity [GO:0004778]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]	GO:0003986; GO:0004778; GO:0005782; GO:0005829; GO:0006633; GO:0006637; GO:0006699; GO:0009062; GO:0010561; GO:0016289; GO:0016559; GO:0033540; GO:0033882; GO:0036109; GO:0043649; GO:0047603; GO:0047617; GO:0047994; GO:0052815; GO:0052816; GO:0141126
GN004522	GN004522.1	Q62280	67.9	78	523	418	3.83e-20	96.3	SSXT_MOUSE	Protein SSXT (Protein SYT) (Synovial sarcoma-associated Ss18-alpha)	Mus musculus (Mouse)	cell morphogenesis [GO:0000902]; chromatin remodeling [GO:0006338]; cytoskeleton organization [GO:0007010]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of cell differentiation [GO:0045596]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to xenobiotic stimulus [GO:0009410]	transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; GBAF complex [GO:0140288]; microtubule cytoskeleton [GO:0015630]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]	GO:0000226; GO:0000785; GO:0000902; GO:0003713; GO:0005634; GO:0005654; GO:0006338; GO:0006357; GO:0007010; GO:0008284; GO:0009410; GO:0015630; GO:0016514; GO:0035556; GO:0045596; GO:0045944; GO:0048013; GO:0071564; GO:0097150; GO:0140288; GO:1902459
GN004524	GN004524.1	Q6P4W8	74.6	256	257	432	2.81e-134	388	PCH2_XENTR	Pachytene checkpoint protein 2 homolog (Thyroid hormone receptor interactor 13 homolog) (Thyroid receptor-interacting protein 13 homolog) (TR-interacting protein 13 homolog) (TRIP-13 homolog)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	double-strand break repair [GO:0006302]; meiotic recombination checkpoint signaling [GO:0051598]; oogenesis [GO:0048477]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]		GO:0005524; GO:0006302; GO:0007130; GO:0007131; GO:0007283; GO:0016887; GO:0042802; GO:0048477; GO:0051598
GN004526	GN004526.1	Q6YHK3	24.4	1547	1512	1445	5.38e-100	356	CD109_HUMAN	CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)	Homo sapiens (Human)	negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]	endopeptidase inhibitor activity [GO:0004866]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	GO:0004866; GO:0005576; GO:0005886; GO:0009986; GO:0030512; GO:0031092; GO:0061045
GN004528	GN004528.1	Q9Z221	52.9	70	2274	971	3.94e-10	69.3	PMFBP_RAT	Polyamine-modulated factor 1-binding protein 1 (PMF-1-binding protein) (Outer dense fiber protein 3)	Rattus norvegicus (Rat)	cytoskeleton organization [GO:0007010]; gene expression [GO:0010467]; intracellular protein localization [GO:0008104]; protein-containing complex assembly [GO:0065003]; regulation of protein localization [GO:0032880]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]		cytoplasm [GO:0005737]; outer dense fiber [GO:0001520]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; sperm head-tail coupling apparatus [GO:0120212]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0001520; GO:0005737; GO:0007010; GO:0007283; GO:0007286; GO:0008104; GO:0010467; GO:0032880; GO:0036126; GO:0061827; GO:0065003; GO:0097225; GO:0097228; GO:0120212
GN004529	GN004529.1	A0A087WPF7	33.9	345	1054	1261	5.32e-19	97.1	AUTS2_MOUSE	Autism susceptibility gene 2 protein homolog	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; axon extension [GO:0048675]; dendrite extension [GO:0097484]; innate vocalization behavior [GO:0098582]; neuron migration [GO:0001764]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of transcription by RNA polymerase II [GO:0045944]; righting reflex [GO:0060013]	chromatin binding [GO:0003682]	cytoskeleton [GO:0005856]; growth cone [GO:0030426]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001764; GO:0003682; GO:0005634; GO:0005654; GO:0005856; GO:0010592; GO:0030036; GO:0030426; GO:0035022; GO:0045944; GO:0048675; GO:0060013; GO:0097484; GO:0098582
GN004530	GN004530.1	Q80TQ5	27.3	1053	1011	1018	1.04e-86	304	PKHM2_MOUSE	Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2)	Mus musculus (Mouse)	autophagosome-lysosome fusion [GO:0061909]; Golgi organization [GO:0007030]; late endosome to lysosome transport [GO:1902774]; lysosome localization [GO:0032418]; natural killer cell mediated cytotoxicity [GO:0042267]; regulation of protein localization [GO:0032880]	kinesin binding [GO:0019894]	autolysosome [GO:0044754]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]	GO:0005737; GO:0005764; GO:0005765; GO:0007030; GO:0010008; GO:0019894; GO:0032418; GO:0032880; GO:0042267; GO:0044754; GO:0061909; GO:1902774
GN004550	GN004550.1	P21127	77.0	395	796	795	3.67e-210	616	CD11B_HUMAN	Cyclin-dependent kinase 11B (EC 2.7.11.22) (EC 2.7.11.23) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)	Homo sapiens (Human)	apoptotic process [GO:0006915]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid cohesion, centromeric [GO:0071962]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of centrosome cycle [GO:0046605]; regulation of DNA-templated transcription [GO:0006355]; regulation of mRNA processing [GO:0050684]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA polymerase II promoter clearance [GO:0001111]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; RNA polymerase II CTD heptapeptide repeat S2 kinase activity [GO:0140834]; RNA polymerase II CTD heptapeptide repeat S5 kinase activity [GO:0140836]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cyclin L-CDK11 complex [GO:0180038]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0000278; GO:0000307; GO:0000775; GO:0001111; GO:0001558; GO:0003723; GO:0004672; GO:0004674; GO:0004693; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006355; GO:0006468; GO:0006915; GO:0008353; GO:0016607; GO:0042981; GO:0046605; GO:0048024; GO:0050684; GO:0051726; GO:0071962; GO:0106310; GO:0140834; GO:0140836; GO:0180038
GN004551	GN004551.1	Q28062	35.7	115	208	912	1.88e-12	68.9	PGCB_BOVIN	Brevican core protein	Bos taurus (Bovine)	cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; skeletal system development [GO:0001501]	hyaluronic acid binding [GO:0005540]	extracellular region [GO:0005576]; perineuronal net [GO:0072534]; synapse [GO:0045202]	GO:0001501; GO:0005540; GO:0005576; GO:0007155; GO:0007417; GO:0045202; GO:0072534
GN004552	GN004552.1	P21941	24.5	335	379	496	1.36e-13	75.5	MATN1_HUMAN	Matrilin-1 (Cartilage matrix protein)	Homo sapiens (Human)	extracellular matrix organization [GO:0030198]; protein-containing complex assembly [GO:0065003]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216]; non-collagenous component of basement membrane [GO:0140144]	GO:0005201; GO:0005509; GO:0005576; GO:0030198; GO:0031012; GO:0065003; GO:0120216; GO:0140144
GN004553	GN004553.1	A6H584	26.0	315	379	2640	3.27e-13	75.1	CO6A5_MOUSE	Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain)	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]		collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005589; GO:0030198; GO:0031012
GN004558	GN004558.1	O75376	36.9	613	2653	2440	1.78e-88	327	NCOR1_HUMAN	Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)	Homo sapiens (Human)	locomotor rhythm [GO:0045475]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glycolytic process [GO:0045820]; negative regulation of JNK cascade [GO:0046329]; negative regulation of miRNA transcription [GO:1902894]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription initiation by RNA polymerase II [GO:0060633]; spindle assembly [GO:0051225]	histone deacetylase binding [GO:0042826]; nuclear receptor binding [GO:0016922]; nuclear thyroid hormone receptor binding [GO:0046966]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; membrane [GO:0016020]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	GO:0000118; GO:0000122; GO:0000785; GO:0000976; GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0016020; GO:0016922; GO:0017053; GO:0042826; GO:0045475; GO:0045820; GO:0045892; GO:0045922; GO:0046329; GO:0046966; GO:0051225; GO:0060633; GO:0060766; GO:0061629; GO:0072686; GO:1902894
GN004560	GN004560.1	Q5R8I8	47.6	376	387	409	3.84e-108	326	PISD_PONAB	Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain]	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	lipid droplet formation [GO:0140042]; mitochondrial protein catabolic process [GO:0035694]; phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540]; regulation of mitochondrion organization [GO:0010821]	phosphatidylserine decarboxylase activity [GO:0004609]	cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0004609; GO:0005737; GO:0005739; GO:0005743; GO:0005811; GO:0006646; GO:0010821; GO:0016540; GO:0035694; GO:0140042
GN004561	GN004561.1	Q5REG1	45.7	841	906	963	6.53e-203	607	SART3_PONAB	Spliceosome associated factor 3, U4/U6 recycling protein (Squamous cell carcinoma antigen recognized by T-cells 3) (SART-3)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	mRNA splicing, via spliceosome [GO:0000398]; nucleosome assembly [GO:0006334]; regulation of RNA metabolic process [GO:0051252]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]; transcription elongation-coupled chromatin remodeling [GO:0140673]	histone binding [GO:0042393]; protein-macromolecule adaptor activity [GO:0030674]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]; U6atac snRNA binding [GO:0030624]; ubiquitin-specific protease binding [GO:1990381]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U4/U6 snRNP [GO:0071001]; U6atac snRNP [GO:0005691]	GO:0000244; GO:0000387; GO:0000398; GO:0005634; GO:0005654; GO:0005691; GO:0005737; GO:0006334; GO:0015030; GO:0016607; GO:0017070; GO:0030621; GO:0030624; GO:0030674; GO:0042393; GO:0051252; GO:0071001; GO:0140673; GO:1990381
GN004562	GN004562.1	Q8N0N3	50.6	354	552	366	7.35e-124	371	BGBP_PENMO	Beta-1,3-glucan-binding protein (GBP)	Penaeus monodon (Giant tiger prawn)	carbohydrate metabolic process [GO:0005975]; innate immune response [GO:0045087]	(1->3)-beta-D-glucan binding [GO:0001872]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	extracellular region [GO:0005576]	GO:0001872; GO:0004553; GO:0005576; GO:0005975; GO:0045087
GN004563	GN004563.1	F4KF65	26.6	387	461	519	8.91e-24	107	IMPA9_ARATH	Importin subunit alpha-9 (IMPa-9)	Arabidopsis thaliana (Mouse-ear cress)	protein import into nucleus [GO:0006606]	nuclear import signal receptor activity [GO:0061608]	cytoplasm [GO:0005737]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear envelope [GO:0005635]	GO:0005635; GO:0005737; GO:0006606; GO:0042564; GO:0061608
GN004565	GN004565.1	Q5XGY9	60.3	73	76	205	1.38e-20	83.6	MND1_XENLA	Meiotic nuclear division protein 1 homolog	Xenopus laevis (African clawed frog)	reciprocal meiotic recombination [GO:0007131]	double-stranded DNA binding [GO:0003690]	nucleus [GO:0005634]	GO:0003690; GO:0005634; GO:0007131
GN004568	GN004568.1	Q4V7C6	67.0	227	242	693	5.22e-101	311	GUAA_RAT	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase)	Rattus norvegicus (Rat)	GMP biosynthetic process [GO:0006177]; GMP salvage [GO:0032263]; response to L-cysteine [GO:1901367]; response to xenobiotic stimulus [GO:0009410]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; GMP synthase (glutamine-hydrolyzing) activity [GO:0003922]; GMP synthase activity [GO:0003921]	cytosol [GO:0005829]	GO:0003921; GO:0003922; GO:0005524; GO:0005829; GO:0006177; GO:0009410; GO:0019899; GO:0032263; GO:1901367
GN004570	GN004570.1	Q6NRW5	56.5	214	220	303	5.90e-84	254	CDIN1_XENLA	CDAN1-interacting nuclease 1	Xenopus laevis (African clawed frog)	erythrocyte differentiation [GO:0030218]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0030218
GN004571	GN004571.1	Q9ULI1	33.3	231	421	1742	6.47e-27	117	NWD2_HUMAN	NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239)	Homo sapiens (Human)			synapse [GO:0045202]	GO:0045202
GN004575	GN004575.1	Q66T02	35.9	808	1442	1073	1.44e-136	451	PKHG5_MOUSE	Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Synectin-binding RhoA exchange factor) (SYX)	Mus musculus (Mouse)	angiogenesis [GO:0001525]; endothelial cell chemotaxis [GO:0035767]; endothelial cell migration [GO:0043542]; regulation protein catabolic process at presynapse [GO:0140251]	guanyl-nucleotide exchange factor activity [GO:0005085]	anchoring junction [GO:0070161]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0001525; GO:0005085; GO:0005737; GO:0005886; GO:0005911; GO:0030027; GO:0030139; GO:0035767; GO:0043542; GO:0048471; GO:0070161; GO:0098793; GO:0140251
GN004576	GN004576.1	F1QR43	48.2	525	594	586	3.93e-170	499	GLCEB_DANRE	D-glucuronyl C5-epimerase B (EC 5.1.3.17)	Danio rerio (Zebrafish) (Brachydanio rerio)	heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin proteoglycan biosynthetic process [GO:0030210]	heparosan-N-sulfate-glucuronate 5-epimerase activity [GO:0047464]; identical protein binding [GO:0042802]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005794; GO:0015012; GO:0030210; GO:0042802; GO:0047464
GN004579	GN004579.1	B2GV54	36.0	356	345	408	6.86e-63	208	NCEH1_RAT	Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1)	Rattus norvegicus (Rat)	ether lipid metabolic process [GO:0046485]; protein dephosphorylation [GO:0006470]; xenobiotic metabolic process [GO:0006805]	acetylalkylglycerol acetylhydrolase activity [GO:0047378]; phosphate ion binding [GO:0042301]; serine hydrolase activity [GO:0017171]; sterol ester esterase activity [GO:0004771]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004771; GO:0005886; GO:0006470; GO:0006805; GO:0016020; GO:0017171; GO:0042301; GO:0046485; GO:0047378
GN004582	GN004582.1	G9JJU2	49.7	159	222	172	8.42e-44	147	GPX_PROCL	Glutathione peroxidase (PcGPx) (Se-PcGPx) (EC 1.11.1.9)	Procambarus clarkii (Red swamp crayfish) (Cambarus clarkii)	response to oxidative stress [GO:0006979]	glutathione peroxidase activity [GO:0004602]		GO:0004602; GO:0006979
GN004583	GN004583.1	P91778	46.5	269	288	508	3.57e-73	236	AMY_PECMA	Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)	Pecten maximus (King scallop) (Pilgrim's clam)	carbohydrate metabolic process [GO:0005975]	alpha-amylase activity [GO:0004556]; cation binding [GO:0043169]		GO:0004556; GO:0005975; GO:0043169
GN004586	GN004586.1	P10180	35.3	960	1275	2175	1.28e-116	406	CUT_DROME	Homeobox protein cut	Drosophila melanogaster (Fruit fly)	antennal development [GO:0007469]; antennal joint development [GO:0048098]; central nervous system development [GO:0007417]; compound eye morphogenesis [GO:0001745]; dendrite arborization [GO:0140059]; dendrite guidance [GO:0070983]; dendrite morphogenesis [GO:0048813]; female gonad development [GO:0008585]; formation of a compartment boundary [GO:0060288]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; Malpighian tubule bud morphogenesis [GO:0061332]; Malpighian tubule morphogenesis [GO:0007443]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]; spiracle morphogenesis, open tracheal system [GO:0035277]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]	GO:0000122; GO:0000976; GO:0000977; GO:0000981; GO:0001745; GO:0003677; GO:0005634; GO:0006355; GO:0006357; GO:0007417; GO:0007422; GO:0007424; GO:0007443; GO:0007469; GO:0007605; GO:0008585; GO:0008587; GO:0035277; GO:0048098; GO:0048477; GO:0048813; GO:0060288; GO:0061332; GO:0070983; GO:0140059
GN004589	GN004589.1	Q6UWM7	50.6	348	367	567	7.47e-130	386	LCTL_HUMAN	Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; lens morphogenesis in camera-type eye [GO:0002089]	hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	brush border [GO:0005903]; endoplasmic reticulum membrane [GO:0005789]	GO:0002089; GO:0004553; GO:0005789; GO:0005903; GO:0005975
GN004590	GN004590.1	Q6UWM7	49.6	353	393	567	2.28e-122	368	LCTL_HUMAN	Lactase-like protein (Klotho/lactase-phlorizin hydrolase-related protein)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; lens morphogenesis in camera-type eye [GO:0002089]	hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	brush border [GO:0005903]; endoplasmic reticulum membrane [GO:0005789]	GO:0002089; GO:0004553; GO:0005789; GO:0005903; GO:0005975
GN004591	GN004591.1	P09848	28.9	515	316	1927	1.01e-55	198	LPH_HUMAN	Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)]	Homo sapiens (Human)	cellobiose catabolic process [GO:2000892]; glycosylceramide catabolic process [GO:0046477]; lactose catabolic process [GO:0005990]; quercetin catabolic process [GO:1901733]	beta-glucosidase activity [GO:0008422]; cellobiose glucosidase activity [GO:0080079]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; lactase activity [GO:0000016]; phlorizin hydrolase activity [GO:0140749]; protein homodimerization activity [GO:0042803]	apical plasma membrane [GO:0016324]; external side of apical plasma membrane [GO:0098591]; plasma membrane [GO:0005886]	GO:0000016; GO:0004336; GO:0004348; GO:0005886; GO:0005990; GO:0008422; GO:0016324; GO:0042803; GO:0046477; GO:0080079; GO:0098591; GO:0140749; GO:1901733; GO:2000892
GN004592	GN004592.1	Q5RF65	59.3	86	138	469	2.69e-30	116	GBA3_PONAB	Cytosolic beta-glucosidase (EC 3.2.1.21) (Cytosolic galactosylceramidase) (EC 3.2.1.46) (Cytosolic glucosylceramidase) (EC 3.2.1.45) (Cytosolic glycosylceramidase) (Cytosolic GCase)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	beta-glucoside catabolic process [GO:1901805]; carbohydrate catabolic process [GO:0016052]; galactosylceramide catabolic process [GO:0006683]; glucosylceramide catabolic process [GO:0006680]	beta-galactosidase activity [GO:0004565]; beta-glucosidase activity [GO:0008422]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glycosylceramidase activity [GO:0017042]	cytosol [GO:0005829]	GO:0004336; GO:0004348; GO:0004565; GO:0005829; GO:0006680; GO:0006683; GO:0008422; GO:0016052; GO:0017042; GO:1901805
GN004593	GN004593.1	Q9SPP9	39.0	118	113	540	1.09e-13	68.9	RG1_RAUSE	Raucaffricine-O-beta-D-glucosidase (Raucaffricine beta-glucosidase) (RsRG) (EC 3.2.1.125) (Vomilenine glucosyltransferase) (RsVGT) (EC 2.4.1.219)	Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum)	alkaloid biosynthetic process [GO:0009821]; carbohydrate metabolic process [GO:0005975]	raucaffricine beta-glucosidase activity [GO:0050247]; vomilenine glucosyltransferase activity [GO:0050506]		GO:0005975; GO:0009821; GO:0050247; GO:0050506
GN004594	GN004594.1	W5PLZ6	45.8	321	309	1931	2.46e-86	286	LPH_SHEEP	Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)]	Ovis aries (Sheep)	cellobiose catabolic process [GO:2000892]; glycosylceramide catabolic process [GO:0046477]; lactose catabolic process [GO:0005990]; quercetin catabolic process [GO:1901733]	beta-glucosidase activity [GO:0008422]; cellobiose glucosidase activity [GO:0080079]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; lactase activity [GO:0000016]; phlorizin hydrolase activity [GO:0140749]	apical plasma membrane [GO:0016324]	GO:0000016; GO:0004336; GO:0004348; GO:0005990; GO:0008422; GO:0016324; GO:0046477; GO:0080079; GO:0140749; GO:1901733; GO:2000892
GN004598	GN004598.1	Q3BCR8	33.8	231	223	245	8.55e-38	134	TPMT_PANTR	Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase)	Pan troglodytes (Chimpanzee)	xenobiotic metabolic process [GO:0006805]	S-adenosyl-L-methionine binding [GO:1904047]; thiopurine S-methyltransferase activity [GO:0008119]	cytoplasm [GO:0005737]	GO:0005737; GO:0006805; GO:0008119; GO:1904047
GN004599	GN004599.1	Q9H5Z1	67.5	523	573	703	1.90e-250	707	DHX35_HUMAN	Probable ATP-dependent RNA helicase DHX35 (EC 3.6.4.13) (DEAH box protein 35)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of IP-10 production [GO:0071660]; positive regulation of RIG-I signaling pathway [GO:1900246]	ATP hydrolysis activity [GO:0016887]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; RNA helicase activity [GO:0003724]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000398; GO:0003690; GO:0003724; GO:0003725; GO:0004386; GO:0005634; GO:0005654; GO:0005737; GO:0016887; GO:0032728; GO:0032755; GO:0071013; GO:0071660; GO:0140374; GO:1900246
GN004601	GN004601.1	Q9VZW5	28.1	302	398	549	9.31e-18	88.6	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN004602	GN004602.1	Q32P85	84.3	83	135	96	1.02e-43	141	DLRB2_BOVIN	Dynein light chain roadblock-type 2 (Dynein light chain 2B, cytoplasmic)	Bos taurus (Bovine)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005813; GO:0005868; GO:0007018; GO:0045505
GN004603	GN004603.1	Q8K0E1	52.6	192	196	283	1.42e-68	213	KCD15_MOUSE	BTB/POZ domain-containing protein KCTD15 (Potassium channel tetramerization domain-containing protein 15)	Mus musculus (Mouse)	negative regulation of DNA-templated transcription [GO:0045892]; protein homooligomerization [GO:0051260]	identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]	GO:0003714; GO:0005634; GO:0042802; GO:0045892; GO:0051260
GN004609	GN004609.1	P28075	79.6	206	274	263	4.92e-117	339	PSB5_RAT	Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit X) (Proteasome subunit beta-5) (beta-5)	Rattus norvegicus (Rat)	proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis [GO:0006508]; regulation of proteasomal protein catabolic process [GO:0061136]; response to oxidative stress [GO:0006979]	endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; synaptic vesicle [GO:0008021]	GO:0000502; GO:0004175; GO:0004298; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005839; GO:0006508; GO:0006979; GO:0008021; GO:0008233; GO:0010498; GO:0019774; GO:0043161; GO:0061136
GN004610	GN004610.1	Q9R1R2	26.9	245	660	744	4.48e-16	85.9	TRIM3_MOUSE	Tripartite motif-containing protein 3 (EC 2.3.2.27) (RING finger protein 22) (RING finger protein HAC1)	Mus musculus (Mouse)	neural precursor cell proliferation [GO:0061351]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]; toll-like receptor signaling pathway [GO:0002224]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; postsynapse [GO:0098794]	GO:0000209; GO:0002224; GO:0004842; GO:0005737; GO:0005769; GO:0005794; GO:0008270; GO:0016567; GO:0030425; GO:0034141; GO:0042802; GO:0043161; GO:0061351; GO:0061630; GO:0070534; GO:0098794; GO:0098978; GO:0140252
GN004613	GN004613.1	O75818	27.7	191	232	363	3.76e-14	73.9	RPP40_HUMAN	Ribonuclease P protein subunit p40 (RNaseP protein p40) (RNase P subunit 1)	Homo sapiens (Human)	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; RNA processing [GO:0006396]; tRNA 5'-leader removal [GO:0001682]	ribonuclease P activity [GO:0004526]; ribonuclease P RNA binding [GO:0033204]	multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]	GO:0000172; GO:0000447; GO:0001682; GO:0004526; GO:0005634; GO:0005654; GO:0005655; GO:0006396; GO:0030681; GO:0033204
GN004616	GN004616.1	Q8NCN5	48.1	522	539	879	6.00e-164	491	PDPR_HUMAN	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr)	Homo sapiens (Human)	positive regulation of pyruvate decarboxylation to acetyl-CoA [GO:0140176]		cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase (lipoamide) phosphatase complex [GO:0045253]	GO:0005737; GO:0005739; GO:0005759; GO:0045253; GO:0140176
GN004617	GN004617.1	Q05AK5	41.3	436	438	464	2.62e-111	338	MYLIB_DANRE	E3 ubiquitin-protein ligase MYLIP-B (EC 2.3.2.27) (Myosin regulatory light chain-interacting protein B) (MIR-B) (RING-type E3 ubiquitin transferase MYLIP-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	gastrulation [GO:0007369]; negative regulation of Wnt signaling pathway [GO:0030178]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004842; GO:0005737; GO:0005829; GO:0006511; GO:0007369; GO:0016567; GO:0030178; GO:0061630
GN004618	GN004618.1	Q60779	58.6	485	486	478	1.31e-167	484	DRC4_MOUSE	Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8)	Mus musculus (Mouse)	axoneme assembly [GO:0035082]; brain development [GO:0007420]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; intracellular protein localization [GO:0008104]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to cilium [GO:0061512]	microtubule binding [GO:0008017]; small GTPase binding [GO:0031267]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; sperm end piece [GO:0097229]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0000226; GO:0003351; GO:0005576; GO:0005737; GO:0005794; GO:0005829; GO:0005874; GO:0005886; GO:0005929; GO:0005930; GO:0007368; GO:0007420; GO:0008017; GO:0008104; GO:0015630; GO:0030317; GO:0031267; GO:0031514; GO:0035082; GO:0036064; GO:0036126; GO:0045880; GO:0061512; GO:0097225; GO:0097228; GO:0097229; GO:0097729; GO:1903566
GN004622	GN004622.1	P08289	49.0	429	439	524	8.71e-125	375	PPBT_RAT	Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1)	Rattus norvegicus (Rat)	bone mineralization [GO:0030282]; calcium ion homeostasis [GO:0055074]; cementum mineralization [GO:0071529]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; futile creatine cycle [GO:0140651]; inhibition of non-skeletal tissue mineralization [GO:0140928]; phosphate ion homeostasis [GO:0055062]; positive regulation of cold-induced thermogenesis [GO:0120162]; pyridoxal 5'-phosphate metabolic process [GO:0042822]; response to antibiotic [GO:0046677]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to macrophage colony-stimulating factor [GO:0036005]; response to sodium phosphate [GO:1904383]; response to vitamin B6 [GO:0034516]; response to vitamin D [GO:0033280]	5'-nucleotidase activity [GO:0008253]; ADP phosphatase activity [GO:0043262]; alkaline phosphatase activity [GO:0004035]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; inorganic diphosphate phosphatase activity [GO:0004427]; phosphoamidase activity [GO:0050187]; phosphoethanolamine phosphatase activity [GO:0052732]; pyridoxal phosphatase activity [GO:0033883]; pyrophosphatase activity [GO:0016462]	extracellular matrix [GO:0031012]; extracellular membrane-bounded organelle [GO:0065010]; extracellular region [GO:0005576]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	GO:0001958; GO:0003006; GO:0004035; GO:0004427; GO:0005509; GO:0005576; GO:0005758; GO:0005886; GO:0008253; GO:0016462; GO:0016887; GO:0030282; GO:0031012; GO:0031966; GO:0032496; GO:0032868; GO:0033280; GO:0033883; GO:0034516; GO:0036005; GO:0042822; GO:0043262; GO:0046677; GO:0050187; GO:0051384; GO:0052732; GO:0055062; GO:0055074; GO:0065010; GO:0071529; GO:0120162; GO:0140651; GO:0140928; GO:1904383
GN004625	GN004625.1	Q6DWJ6	27.2	290	390	353	2.15e-12	71.2	GP139_HUMAN	Probable G protein-coupled receptor 139 (G protein-coupled receptor PGR3) (G(q)-coupled orphan receptor GPRg1)	Homo sapiens (Human)	G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	identical protein binding [GO:0042802]; neuropeptide receptor activity [GO:0008188]	plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0007200; GO:0008188; GO:0042802
GN004627	GN004627.1	O95395	44.0	275	327	438	1.88e-68	223	GCNT3_HUMAN	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (hC2GnT-M) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase) (C2/4GnT)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via N-acetyl-galactosamine [GO:0016266]	acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0047225]; acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0003829; GO:0005975; GO:0006493; GO:0008109; GO:0008375; GO:0016020; GO:0016266; GO:0047225; GO:0070062
GN004629	GN004629.1	Q5BKW7	38.2	390	435	438	3.53e-101	311	ENPP6_DANRE	Glycerophosphocholine cholinephosphodiesterase ENPP6 (GPC-Cpde) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) (E-NPP 6) (NPP-6)	Danio rerio (Zebrafish) (Brachydanio rerio)	choline metabolic process [GO:0019695]; lipid metabolic process [GO:0006629]	glycerophosphocholine cholinephosphodiesterase activity [GO:0047390]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; phosphoric diester hydrolase activity [GO:0008081]	plasma membrane [GO:0005886]	GO:0005886; GO:0006629; GO:0008081; GO:0008889; GO:0019695; GO:0047390
GN004634	GN004634.1	Q6DDP3	36.5	414	443	441	7.75e-91	285	ENPP6_XENLA	Glycerophosphocholine cholinephosphodiesterase ENPP6 (GPC-Cpde) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) (E-NPP 6) (NPP-6)	Xenopus laevis (African clawed frog)	choline metabolic process [GO:0019695]; lipid metabolic process [GO:0006629]	glycerophosphocholine cholinephosphodiesterase activity [GO:0047390]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; phosphoric diester hydrolase activity [GO:0008081]	plasma membrane [GO:0005886]	GO:0005886; GO:0006629; GO:0008081; GO:0008889; GO:0019695; GO:0047390
GN004635	GN004635.1	Q80WR1	29.8	262	592	248	6.91e-22	98.6	TSN18_MOUSE	Tetraspanin-18 (Tspan-18)	Mus musculus (Mouse)	calcium-ion regulated exocytosis [GO:0017156]; hemostasis [GO:0007599]; inflammatory response [GO:0006954]; protein localization to cell periphery [GO:1990778]; regulation of sprouting angiogenesis [GO:1903670]; regulation of store-operated calcium entry [GO:2001256]	transmembrane transporter binding [GO:0044325]	cell periphery [GO:0071944]; plasma membrane [GO:0005886]	GO:0005886; GO:0006954; GO:0007599; GO:0017156; GO:0044325; GO:0071944; GO:1903670; GO:1990778; GO:2001256
GN004639	GN004639.1	P48065	42.5	574	623	614	2.00e-160	476	S6A12_HUMAN	Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12)	Homo sapiens (Human)	amino acid transport [GO:0006865]; gamma-aminobutyric acid reuptake [GO:0051936]; gamma-aminobutyric acid transport [GO:0015812]; glycine betaine transport [GO:0031460]; monocarboxylic acid transport [GO:0015718]; sodium ion transmembrane transport [GO:0035725]	amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; glycine betaine:sodium:chloride symporter activity [GO:0140814]; monocarboxylic acid transmembrane transporter activity [GO:0008028]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0005332; GO:0005886; GO:0006865; GO:0008028; GO:0015171; GO:0015718; GO:0015812; GO:0016020; GO:0016323; GO:0031460; GO:0035725; GO:0051936; GO:0098793; GO:0140814
GN004640	GN004640.1	Q99884	39.0	582	625	636	1.19e-135	413	SC6A7_HUMAN	Sodium-dependent proline transporter (Solute carrier family 6 member 7)	Homo sapiens (Human)	glycine import across plasma membrane [GO:1903804]; neurotransmitter transport [GO:0006836]; proline transport [GO:0015824]; protein catabolic process [GO:0030163]; sodium ion transmembrane transport [GO:0035725]	L-proline transmembrane transporter activity [GO:0015193]; proline:sodium symporter activity [GO:0005298]	membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005298; GO:0005886; GO:0006836; GO:0015193; GO:0015824; GO:0016020; GO:0030163; GO:0035725; GO:0045202; GO:0097060; GO:1903804
GN004644	GN004644.1	A0A0G2K344	54.3	1066	1055	1068	0.0	1174	PK3CA_RAT	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)	Rattus norvegicus (Rat)	actin cytoskeleton organization [GO:0030036]; adipose tissue development [GO:0060612]; autosome genomic imprinting [GO:0141068]; cardiac muscle cell contraction [GO:0086003]; cell migration [GO:0016477]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to insulin stimulus [GO:0032869]; energy homeostasis [GO:0097009]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; liver development [GO:0001889]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of anoikis [GO:2000811]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of actin filament organization [GO:0110053]; regulation of cellular respiration [GO:0043457]; regulation of gene expression [GO:0010468]; regulation of multicellular organism growth [GO:0040014]; regulation of protein phosphorylation [GO:0001932]; relaxation of cardiac muscle [GO:0055119]; response to activity [GO:0014823]; response to butyrate [GO:1903544]; response to dexamethasone [GO:0071548]; response to L-leucine [GO:0043201]; response to muscle inactivity [GO:0014870]; response to muscle stretch [GO:0035994]; TORC2 signaling [GO:0038203]; vascular endothelial growth factor signaling pathway [GO:0038084]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; insulin receptor substrate binding [GO:0043560]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]	GO:0001889; GO:0001932; GO:0004674; GO:0005829; GO:0005886; GO:0005942; GO:0005943; GO:0005944; GO:0006006; GO:0008286; GO:0010468; GO:0010629; GO:0014704; GO:0014823; GO:0014870; GO:0016303; GO:0016477; GO:0030027; GO:0030036; GO:0030295; GO:0030835; GO:0032869; GO:0035005; GO:0035994; GO:0036092; GO:0038084; GO:0038203; GO:0040014; GO:0043201; GO:0043457; GO:0043491; GO:0043524; GO:0043560; GO:0045860; GO:0046854; GO:0046934; GO:0048009; GO:0048015; GO:0048661; GO:0051897; GO:0055119; GO:0060612; GO:0071333; GO:0071464; GO:0071548; GO:0086003; GO:0097009; GO:0106310; GO:0110053; GO:0141068; GO:1903544; GO:1905477; GO:2000270; GO:2000811
GN004645	GN004645.1	Q7ZUC2	38.5	343	346	356	3.30e-67	218	CAB45_DANRE	45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4)	Danio rerio (Zebrafish) (Brachydanio rerio)	calcium-ion regulated exocytosis [GO:0017156]; sprouting angiogenesis [GO:0002040]	calcium ion binding [GO:0005509]	endoplasmic reticulum [GO:0005783]; Golgi lumen [GO:0005796]	GO:0002040; GO:0005509; GO:0005783; GO:0005796; GO:0017156
GN004646	GN004646.1	Q9UK58	65.4	338	463	526	8.41e-146	429	CCNL1_HUMAN	Cyclin-L1 (Cyclin-L)	Homo sapiens (Human)	regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of centrosome cycle [GO:0046605]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin L-CDK11 complex [GO:0180038]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000307; GO:0005634; GO:0005654; GO:0006357; GO:0016538; GO:0016604; GO:0016607; GO:0042981; GO:0043484; GO:0046605; GO:0048024; GO:0051726; GO:0180038
GN004649	GN004649.1	Q3SYW6	62.7	627	662	912	1.37e-267	762	EIF3C_BOVIN	Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)	Bos taurus (Bovine)	formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]	GO:0001732; GO:0003723; GO:0003743; GO:0005829; GO:0005852; GO:0006413; GO:0016282; GO:0031369; GO:0033290; GO:0071541
GN004650	GN004650.1	B4MRZ8	58.4	178	213	919	2.77e-50	177	EIF3C_DROWI	Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8)	Drosophila willistoni (Fruit fly)	formation of cytoplasmic translation initiation complex [GO:0001732]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]	GO:0001732; GO:0003723; GO:0003743; GO:0005852; GO:0016282; GO:0031369; GO:0033290
GN004651	GN004651.1	Q5ZHX9	67.2	384	446	409	1.54e-190	538	DPH1_CHICK	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (EC 2.5.1.108) (Diphthamide biosynthesis protein 1) (Diphtheria toxin resistance protein 1) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1)	Gallus gallus (Chicken)	protein histidyl modification to diphthamide [GO:0017183]	2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560]; 4 iron, 4 sulfur cluster binding [GO:0051539]	2-(3-amino-3-carboxypropyl)histidine synthase complex [GO:0120513]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0017183; GO:0051539; GO:0090560; GO:0120513
GN004652	GN004652.1	Q5ZII9	49.8	824	818	827	9.40e-294	832	TFP11_CHICK	Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1)	Gallus gallus (Chicken)	negative regulation of protein-containing complex assembly [GO:0031333]; spliceosomal complex disassembly [GO:0000390]	nucleic acid binding [GO:0003676]	catalytic step 2 spliceosome [GO:0071013]; chromosome, telomeric region [GO:0000781]; extracellular matrix [GO:0031012]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; spliceosomal complex [GO:0005681]; U2-type post-mRNA release spliceosomal complex [GO:0071008]	GO:0000390; GO:0000781; GO:0003676; GO:0005681; GO:0005730; GO:0016607; GO:0031012; GO:0031333; GO:0071008; GO:0071013
GN004653	GN004653.1	F1R520	36.5	921	958	954	2.75e-172	530	CSTN1_DANRE	Calsyntenin-1	Danio rerio (Zebrafish) (Brachydanio rerio)	axon arborization [GO:0140060]; axonal transport [GO:0098930]; endocytic recycling [GO:0032456]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; homophilic cell-cell adhesion [GO:0007156]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; regulation of collateral sprouting [GO:0048670]	calcium ion binding [GO:0005509]; cell-cell adhesion mediator activity [GO:0098632]	axon [GO:0030424]; cell surface [GO:0009986]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]	GO:0000139; GO:0005509; GO:0005789; GO:0007156; GO:0009986; GO:0030424; GO:0030951; GO:0032456; GO:0045211; GO:0048670; GO:0050806; GO:0051965; GO:0098632; GO:0098839; GO:0098930; GO:0140060
GN004656	GN004656.1	Q7SY23	58.7	138	142	556	6.62e-51	172	AL4A1_DANRE	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)	Danio rerio (Zebrafish) (Brachydanio rerio)		L-glutamate gamma-semialdehyde dehydrogenase activity [GO:0003842]	mitochondrial matrix [GO:0005759]	GO:0003842; GO:0005759
GN004657	GN004657.1	O75934	69.0	187	191	225	1.54e-85	254	SPF27_HUMAN	Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27)	Homo sapiens (Human)	mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]		catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000375; GO:0000398; GO:0000974; GO:0005634; GO:0005654; GO:0005681; GO:0005730; GO:0008380; GO:0016607; GO:0071006; GO:0071007; GO:0071013; GO:0071014; GO:0071020
GN004658	GN004658.1	Q6GVH4	48.2	691	624	698	1.47e-176	520	GGNB2_CHICK	Gametogenetin-binding protein 2 (Protein ZNF403)	Gallus gallus (Chicken)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN004661	GN004661.1	G5EFC3	39.0	441	776	558	4.72e-83	278	KCNAG_CAEEL	Potassium voltage-gated channel protein egl-36 (Egg-laying defective protein 36)	Caenorhabditis elegans	action potential [GO:0001508]; monoatomic ion transmembrane transport [GO:0034220]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic ion channel activity [GO:0005244]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005244; GO:0005251; GO:0008076; GO:0016020; GO:0032590; GO:0032809; GO:0034220; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN004662	GN004662.1	Q0E908	27.2	489	927	818	7.89e-39	159	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN004663	GN004663.1	Q7ZXF1	37.4	1103	1064	1078	6.34e-217	653	MTMR4_XENLA	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase)	Xenopus laevis (African clawed frog)	glycerophospholipid biosynthetic process [GO:0046474]; midbody abscission [GO:0061952]; negative regulation of endocytic recycling [GO:2001136]; phagosome maturation [GO:0090382]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of autophagy [GO:0010506]	metal ion binding [GO:0046872]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; protein phosphatase binding [GO:0019903]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; early phagosome membrane [GO:0036186]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038]	GO:0004438; GO:0004722; GO:0005829; GO:0010008; GO:0010506; GO:0016020; GO:0019903; GO:0031901; GO:0031902; GO:0036186; GO:0046474; GO:0046856; GO:0046872; GO:0052629; GO:0055038; GO:0060090; GO:0061952; GO:0090382; GO:2001136
GN004664	GN004664.1	Q8TEP8	29.5	1205	2642	2537	6.19e-133	472	CE192_HUMAN	Centrosomal protein of 192 kDa (Cep192) (Cep192/SPD-2)	Homo sapiens (Human)	centriole replication [GO:0007099]; centrosome cycle [GO:0007098]; centrosome-templated microtubule nucleation [GO:0090222]; mitotic spindle assembly [GO:0090307]; protein localization to centrosome [GO:0071539]	phosphatase binding [GO:0019902]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; pericentriolar material [GO:0000242]; procentriole [GO:0120098]; procentriole replication complex [GO:0120099]	GO:0000242; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0007098; GO:0007099; GO:0019902; GO:0036064; GO:0071539; GO:0090222; GO:0090307; GO:0120098; GO:0120099
GN004665	GN004665.1	Q5M8L8	45.2	186	270	230	5.84e-45	154	HVCN1_XENTR	Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; proton transmembrane transport [GO:1902600]	voltage-gated proton channel activity [GO:0030171]	plasma membrane [GO:0005886]	GO:0005886; GO:0030171; GO:0071294; GO:0071467; GO:1902600
GN004666	GN004666.1	Q28FI8	47.3	239	279	273	1.39e-70	221	NEUFC_XENTR	Neuferricin (Cytochrome b5 domain-containing protein 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			extracellular region [GO:0005576]	GO:0005576
GN004668	GN004668.1	Q90687	61.8	610	613	593	6.33e-247	695	PTN11_CHICK	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (SH-PTP2) (cSH-PTP2)	Gallus gallus (Chicken)	cellular response to epidermal growth factor stimulus [GO:0071364]; ERBB signaling pathway [GO:0038127]; negative regulation of chondrocyte differentiation [GO:0032331]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of ossification [GO:0045778]	cell adhesion molecule binding [GO:0050839]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004725; GO:0004726; GO:0005634; GO:0005737; GO:0030971; GO:0032331; GO:0038127; GO:0045778; GO:0050839; GO:0070374; GO:0071364
GN004669	GN004669.1	Q6DDL7	49.1	440	475	460	2.87e-141	416	UN93A_XENLA	N-acetylglucosamine transporter UNC93A (Protein unc-93 homolog A) (Unc-93A)	Xenopus laevis (African clawed frog)		N-acetylglucosamine transmembrane transporter activity [GO:0015572]	plasma membrane [GO:0005886]	GO:0005886; GO:0015572
GN004670	GN004670.1	Q0P5J9	47.6	349	491	312	2.81e-93	288	RPR1A_BOVIN	Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein)	Bos taurus (Bovine)	mRNA 3'-end processing [GO:0031124]; RNA polymerase II promoter clearance [GO:0001111]	identical protein binding [GO:0042802]; RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550]	GO:0000993; GO:0001111; GO:0005634; GO:0005654; GO:0031124; GO:0042802; GO:0097550; GO:0099122
GN004672	GN004672.1	Q8BG40	55.1	677	830	658	5.47e-79	271	KTNB1_MOUSE	Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin)	Mus musculus (Mouse)	microtubule depolymerization [GO:0007019]; microtubule severing [GO:0051013]; mitotic chromosome movement towards spindle pole [GO:0007079]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of apoptotic process [GO:0043065]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of neuron projection development [GO:0010976]	ATPase regulator activity [GO:0060590]; dynein complex binding [GO:0070840]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]	axon [GO:0030424]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; katanin complex [GO:0008352]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; spindle [GO:0005819]; spindle pole [GO:0000922]	GO:0000922; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0005874; GO:0005886; GO:0007019; GO:0007026; GO:0007079; GO:0008017; GO:0008352; GO:0010976; GO:0015630; GO:0030424; GO:0030426; GO:0030496; GO:0031117; GO:0043025; GO:0043065; GO:0046982; GO:0051013; GO:0060590; GO:0070840
GN004675	GN004675.1	Q9HD42	49.4	79	108	196	3.92e-16	73.2	CHM1A_HUMAN	Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1)	Homo sapiens (Human)	autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell division [GO:0051301]; ESCRT III complex disassembly [GO:1904903]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport [GO:0045324]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic chromosome condensation [GO:0007076]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; negative regulation of gene expression [GO:0010629]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle fusion with vacuole [GO:0051469]; vesicle-mediated transport [GO:0016192]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; ESCRT III complex [GO:0000815]; extracellular exosome [GO:0070062]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; multivesicular body membrane [GO:0032585]; nuclear matrix [GO:0016363]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0000421; GO:0000776; GO:0000794; GO:0000815; GO:0001778; GO:0005643; GO:0005654; GO:0005765; GO:0005769; GO:0005815; GO:0005828; GO:0005829; GO:0005886; GO:0006914; GO:0006997; GO:0007076; GO:0007080; GO:0008237; GO:0008270; GO:0010629; GO:0010824; GO:0012505; GO:0016192; GO:0016363; GO:0019904; GO:0030496; GO:0031468; GO:0032585; GO:0036258; GO:0039702; GO:0042802; GO:0042803; GO:0043162; GO:0045324; GO:0046761; GO:0051301; GO:0051469; GO:0061763; GO:0061952; GO:0070062; GO:0071985; GO:0090148; GO:0097352; GO:1901673; GO:1902774; GO:1904903; GO:1904930
GN004676	GN004676.1	P82916	33.7	89	189	130	4.58e-13	66.2	RT17_BOVIN	Small ribosomal subunit protein uS17m (28S ribosomal protein S17, mitochondrial) (MRP-S17) (S17mt)	Bos taurus (Bovine)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005763; GO:0006412
GN004677	GN004677.1	Q66IJ4	56.8	389	406	419	8.84e-143	416	PIGM_XENTR	GPI alpha-1,4-mannosyltransferase I, catalytic subunit (EC 2.4.1.-) (GPI mannosyltransferase I) (GPI-MT-I) (Phosphatidylinositol-glycan biosynthesis class M protein) (PIG-M)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	GPI anchor biosynthetic process [GO:0006506]	dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity [GO:0180041]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-mannosyltransferase I complex [GO:1990529]	GO:0000030; GO:0005789; GO:0006506; GO:0180041; GO:1990529
GN004678	GN004678.1	Q9UKV5	41.6	262	305	643	7.63e-46	167	AMFR_HUMAN	E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)	Homo sapiens (Human)	endoplasmic reticulum mannose trimming [GO:1904380]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; learning or memory [GO:0007611]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-canonical NF-kappaB signal transduction [GO:0038061]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; protein unfolding [GO:0043335]; regulation of SREBP signaling pathway [GO:2000638]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]	BAT3 complex binding [GO:1904288]; identical protein binding [GO:0042802]; protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]; signaling receptor activity [GO:0038023]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; ubiquitin-ubiquitin ligase activity [GO:0034450]	ATPase complex [GO:1904949]; dendrite [GO:0030425]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; growth cone [GO:0030426]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000209; GO:0004842; GO:0005783; GO:0005789; GO:0006511; GO:0007165; GO:0007611; GO:0016020; GO:0030425; GO:0030426; GO:0030674; GO:0030968; GO:0032991; GO:0034450; GO:0036503; GO:0036513; GO:0038023; GO:0038061; GO:0042802; GO:0043025; GO:0043130; GO:0043161; GO:0043335; GO:0044314; GO:0044322; GO:0048471; GO:0051087; GO:0051865; GO:0061630; GO:0070936; GO:0090090; GO:1904288; GO:1904380; GO:1904949; GO:1990381; GO:2000638
GN004680	GN004680.1	F1QB30	50.4	337	359	620	8.51e-97	303	AMFR_DANRE	E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor)	Danio rerio (Zebrafish) (Brachydanio rerio)	endoplasmic reticulum unfolded protein response [GO:0030968]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; response to endoplasmic reticulum stress [GO:0034976]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000209; GO:0005783; GO:0005789; GO:0006511; GO:0030968; GO:0034976; GO:0043130; GO:0061630; GO:0070936
GN004681	GN004681.1	Q9J4Z4	28.7	223	433	592	2.23e-10	66.2	V246_FOWPN	Putative ankyrin repeat protein FPV246	Fowlpox virus (strain NVSL) (FPV)				
GN004682	GN004682.1	Q5M8N4	45.6	228	237	293	8.63e-68	213	D39U1_MOUSE	Epimerase family protein SDR39U1 (EC 1.1.1.-) (Short-chain dehydrogenase/reductase family 39U member 1)	Mus musculus (Mouse)				
GN004683	GN004683.1	P22892	60.8	824	856	822	0.0	931	AP1G1_MOUSE	AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin adaptor protein 1 core) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma-adaptin) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1)	Mus musculus (Mouse)	basolateral protein secretion [GO:0110010]; endosome to melanosome transport [GO:0035646]; Golgi to lysosome transport [GO:0090160]; Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192]	clathrin-cargo adaptor activity [GO:0035615]; collagen binding [GO:0005518]; GTP-dependent protein binding [GO:0030742]; kinesin binding [GO:0019894]; small GTPase binding [GO:0031267]	AP-1 adaptor complex [GO:0030121]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	GO:0005518; GO:0005737; GO:0005765; GO:0005769; GO:0005794; GO:0005802; GO:0005829; GO:0005905; GO:0006886; GO:0006896; GO:0016182; GO:0016192; GO:0019894; GO:0030121; GO:0030136; GO:0030742; GO:0031267; GO:0032588; GO:0035615; GO:0035646; GO:0043323; GO:0045954; GO:0048471; GO:0048488; GO:0055037; GO:0060155; GO:0090160; GO:0098793; GO:0110010; GO:1903232
GN004684	GN004684.1	P0DUE1	23.9	331	404	415	1.79e-12	72.0	STING_MAGGI	Stimulator of interferon genes protein (TIR-STING) (Probable NAD(+) hydrolase) (EC 3.2.2.6)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	activation of innate immune response [GO:0002218]; autophagosome assembly [GO:0000045]; innate immune response [GO:0045087]; positive regulation of macroautophagy [GO:0016239]; positive regulation of type I interferon production [GO:0032481]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; NAD+ nucleosidase activity, cyclic ADP-ribose generating [GO:0061809]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]	GO:0000045; GO:0002218; GO:0005776; GO:0005789; GO:0007165; GO:0016239; GO:0032481; GO:0035438; GO:0045087; GO:0061507; GO:0061709; GO:0061809
GN004688	GN004688.1	C6EUD4	55.0	469	467	478	4.02e-174	500	APSCT_FASHE	Succinyl-CoA:acetate/propanoyl-CoA:succinate CoA transferase (EC 2.8.3.18) (EC 2.8.3.27) (Acetate:succinate CoA-transferase) (ASCT) (Propionate:succinate CoA-transferase) (PSCT) (Short-chain acyl-CoA-transferase)	Fasciola hepatica (Liver fluke)	acetate metabolic process [GO:0006083]	acetate CoA-transferase activity [GO:0008775]; propionyl-CoA:succinate CoA-transferase activity [GO:0043821]	mitochondrion [GO:0005739]	GO:0005739; GO:0006083; GO:0008775; GO:0043821
GN004689	GN004689.1	Q9ULX7	36.9	295	310	337	2.62e-53	180	CAH14_HUMAN	Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV)	Homo sapiens (Human)		carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004089; GO:0005886; GO:0008270; GO:0016020; GO:0016323; GO:0016324
GN004690	GN004690.1	Q6AZB8	31.2	189	257	349	7.52e-20	90.5	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN004692	GN004692.1	Q9ER75	60.8	102	510	438	1.55e-27	118	IRX6_MOUSE	Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6)	Mus musculus (Mouse)	cell development [GO:0048468]; detection of visible light [GO:0009584]; negative regulation of DNA-templated transcription [GO:0045892]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; retina layer formation [GO:0010842]; retinal bipolar neuron differentiation [GO:0060040]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001227; GO:0001228; GO:0005634; GO:0006357; GO:0009584; GO:0010842; GO:0030182; GO:0045892; GO:0045893; GO:0048468; GO:0060040
GN004694	GN004694.1	Q99MS3	36.7	150	164	194	2.45e-26	101	MP17L_MOUSE	Mpv17-like protein (M-LP)	Mus musculus (Mouse)	negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; reactive oxygen species metabolic process [GO:0072593]		cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0005737; GO:0005739; GO:0005777; GO:0005778; GO:0010730; GO:0072593; GO:1901029
GN004695	GN004695.1	Q4L208	58.5	521	627	575	3.61e-195	563	SL9A8_RAT	Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8)	Rattus norvegicus (Rat)	acrosome assembly [GO:0001675]; Golgi lumen acidification [GO:0061795]; potassium ion transport [GO:0006813]; proton transmembrane transport [GO:1902600]; regulation of intracellular pH [GO:0051453]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; multivesicular body membrane [GO:0032585]; trans-Golgi network membrane [GO:0032588]	GO:0000139; GO:0001669; GO:0001675; GO:0005794; GO:0006813; GO:0006814; GO:0015385; GO:0015386; GO:0016324; GO:0032585; GO:0032588; GO:0035725; GO:0051453; GO:0061795; GO:1902600
GN004696	GN004696.1	Q6IND4	39.9	557	586	556	2.06e-122	375	EEPD1_XENLA	Endonuclease/exonuclease/phosphatase family domain-containing protein 1	Xenopus laevis (African clawed frog)	DNA repair [GO:0006281]	catalytic activity [GO:0003824]; DNA binding [GO:0003677]	plasma membrane [GO:0005886]	GO:0003677; GO:0003824; GO:0005886; GO:0006281
GN004697	GN004697.1	P70031	22.6	349	376	453	1.19e-13	75.5	CCKAR_XENLA	Cholecystokinin receptor (CCK-XLR)	Xenopus laevis (African clawed frog)	neuropeptide signaling pathway [GO:0007218]	neuropeptide receptor activity [GO:0008188]	plasma membrane [GO:0005886]	GO:0005886; GO:0007218; GO:0008188
GN004700	GN004700.1	Q9UBQ7	51.1	321	327	328	9.37e-110	325	GRHPR_HUMAN	Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81)	Homo sapiens (Human)	dicarboxylic acid metabolic process [GO:0043648]; glyoxylate metabolic process [GO:0046487]	carboxylic acid binding [GO:0031406]; glyoxylate reductase (NADPH) activity [GO:0030267]; hydroxypyruvate reductase (NADH) activity [GO:0008465]; hydroxypyruvate reductase (NADPH) activity [GO:0120509]; hydroxypyruvate reductase [NAD(P)H] activity [GO:0016618]; NAD binding [GO:0051287]; NADPH binding [GO:0070402]; protein homodimerization activity [GO:0042803]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]	GO:0005737; GO:0005739; GO:0005782; GO:0005829; GO:0008465; GO:0016618; GO:0030267; GO:0031406; GO:0042803; GO:0043648; GO:0046487; GO:0051287; GO:0070062; GO:0070402; GO:0120509; GO:1902494
GN004701	GN004701.1	Q91Z53	32.9	328	319	328	1.21e-42	152	GRHPR_MOUSE	Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81)	Mus musculus (Mouse)	dicarboxylic acid metabolic process [GO:0043648]; glyoxylate metabolic process [GO:0046487]	carboxylic acid binding [GO:0031406]; glyoxylate reductase (NADPH) activity [GO:0030267]; hydroxypyruvate reductase (NADH) activity [GO:0008465]; hydroxypyruvate reductase (NADPH) activity [GO:0120509]; hydroxypyruvate reductase [NAD(P)H] activity [GO:0016618]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; NADPH binding [GO:0070402]; protein homodimerization activity [GO:0042803]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0008465; GO:0016618; GO:0030267; GO:0031406; GO:0042803; GO:0043648; GO:0046487; GO:0050661; GO:0051287; GO:0070402; GO:0120509; GO:1902494
GN004702	GN004702.1	Q9UBQ7	46.2	312	313	328	1.21e-88	271	GRHPR_HUMAN	Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81)	Homo sapiens (Human)	dicarboxylic acid metabolic process [GO:0043648]; glyoxylate metabolic process [GO:0046487]	carboxylic acid binding [GO:0031406]; glyoxylate reductase (NADPH) activity [GO:0030267]; hydroxypyruvate reductase (NADH) activity [GO:0008465]; hydroxypyruvate reductase (NADPH) activity [GO:0120509]; hydroxypyruvate reductase [NAD(P)H] activity [GO:0016618]; NAD binding [GO:0051287]; NADPH binding [GO:0070402]; protein homodimerization activity [GO:0042803]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]	GO:0005737; GO:0005739; GO:0005782; GO:0005829; GO:0008465; GO:0016618; GO:0030267; GO:0031406; GO:0042803; GO:0043648; GO:0046487; GO:0051287; GO:0070062; GO:0070402; GO:0120509; GO:1902494
GN004703	GN004703.1	Q6NSJ0	42.5	567	668	714	3.25e-147	447	MYORG_HUMAN	Alpha-galactosidase MYORG (EC 3.2.1.22) (Myogenesis regulating glycosidase) (Nuclear envelope transmembrane protein 37)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; skeletal muscle fiber development [GO:0048741]	alpha-galactosidase activity [GO:0004557]	endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]	GO:0004557; GO:0005789; GO:0005975; GO:0031965; GO:0043568; GO:0048741; GO:0051897
GN004704	GN004704.1	Q60HE5	62.1	66	288	656	1.54e-23	103	MTHR_MACFA	Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	L-methionine metabolic process [GO:0006555]; tetrahydrofolate interconversion [GO:0035999]	FAD binding [GO:0071949]; methylenetetrahydrofolate reductase (NADPH) activity [GO:0106313]	cytosol [GO:0005829]	GO:0005829; GO:0006555; GO:0035999; GO:0071949; GO:0106313
GN004705	GN004705.1	Q8IZH2	52.9	1172	1830	1706	0.0	1176	XRN1_HUMAN	5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)	Homo sapiens (Human)	cellular response to cycloheximide [GO:0071409]; cellular response to puromycin [GO:1905795]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; histone mRNA catabolic process [GO:0071044]; mRNA catabolic process [GO:0006402]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation [GO:0017148]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; response to testosterone [GO:0033574]; rRNA catabolic process [GO:0016075]	5'-3' RNA exonuclease activity [GO:0004534]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; RNA decapping complex [GO:0098745]	GO:0000288; GO:0000290; GO:0000932; GO:0000956; GO:0002151; GO:0003723; GO:0004534; GO:0005634; GO:0005829; GO:0005886; GO:0006402; GO:0016020; GO:0016075; GO:0017148; GO:0030425; GO:0032211; GO:0033574; GO:0043025; GO:0051880; GO:0070034; GO:0071028; GO:0071044; GO:0071409; GO:0098745; GO:1905795
GN004709	GN004709.1	B3DM66	29.6	331	610	518	2.41e-33	137	GP161_XENTR	G protein-coupled receptor 161	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]	G protein-coupled receptor activity [GO:0004930]; signaling adaptor activity [GO:0035591]	non-motile cilium membrane [GO:0098804]; recycling endosome [GO:0055037]	GO:0004930; GO:0007189; GO:0035591; GO:0055037; GO:0098804; GO:1901621
GN004710	GN004710.1	Q12962	76.7	103	138	218	4.20e-50	162	TAF10_HUMAN	Transcription initiation factor TFIID subunit 10 (STAF28) (Transcription initiation factor TFIID 30 kDa subunit) (TAF(II)30) (TAFII-30) (TAFII30)	Homo sapiens (Human)	allantois development [GO:1905069]; chromatin remodeling [GO:0006338]; DNA-templated transcription initiation [GO:0006352]; embryonic placenta development [GO:0001892]; lateral mesodermal cell differentiation [GO:0048371]; limb development [GO:0060173]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; SAGA complex assembly [GO:0036285]; somitogenesis [GO:0001756]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase binding [GO:0070063]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; transcription preinitiation complex [GO:0097550]	GO:0000124; GO:0001756; GO:0001892; GO:0003677; GO:0005634; GO:0005654; GO:0005669; GO:0005737; GO:0006282; GO:0006338; GO:0006352; GO:0006355; GO:0006357; GO:0006366; GO:0006367; GO:0016251; GO:0019899; GO:0030331; GO:0033276; GO:0036285; GO:0042789; GO:0042802; GO:0043484; GO:0045893; GO:0048371; GO:0048471; GO:0051123; GO:0060173; GO:0060261; GO:0070063; GO:0097550; GO:1905069; GO:1990841
GN004711	GN004711.1	O15247	36.0	236	249	247	1.10e-36	132	CLIC2_HUMAN	Chloride intracellular channel protein 2 (Glutaredoxin-like oxidoreductase CLIC2) (EC 1.8.-.-) (Glutaredoxin-like peroxidase CLIC2) (EC 1.11.1.-) (XAP121)	Homo sapiens (Human)	chloride transport [GO:0006821]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; signal transduction [GO:0007165]	chloride channel activity [GO:0005254]; glutathione peroxidase activity [GO:0004602]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0004602; GO:0005254; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006821; GO:0007165; GO:0010880; GO:0010881; GO:0016020
GN004712	GN004712.1	Q5SVZ6	34.1	126	181	1142	1.49e-09	59.7	ZMYM1_HUMAN	Zinc finger MYM-type protein 1	Homo sapiens (Human)		protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0005634; GO:0008270; GO:0046983
GN004713	GN004713.1	Q3T0Z5	38.0	295	295	263	7.74e-37	135	LENG1_BOVIN	Leukocyte receptor cluster member 1 homolog	Bos taurus (Bovine)				
GN004714	GN004714.1	Q61143	36.0	272	434	930	3.17e-39	154	TRPC6_MOUSE	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel) (Transient receptor protein 6) (TRP-6)	Mus musculus (Mouse)	calcium ion transmembrane transport [GO:0070588]; cellular response to hydrogen peroxide [GO:0070301]; negative regulation of dendrite morphogenesis [GO:0050774]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338]	actin binding [GO:0003779]; actinin binding [GO:0042805]; ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; clathrin binding [GO:0030276]; inositol 1,4,5 trisphosphate binding [GO:0070679]; monoatomic cation channel activity [GO:0005261]; monoatomic ion channel activity [GO:0005216]; protein homodimerization activity [GO:0042803]; store-operated calcium channel activity [GO:0015279]	cation channel complex [GO:0034703]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057]	GO:0003779; GO:0005216; GO:0005261; GO:0005262; GO:0005737; GO:0005886; GO:0007204; GO:0007338; GO:0010800; GO:0015279; GO:0016020; GO:0030276; GO:0032414; GO:0034703; GO:0036057; GO:0042803; GO:0042805; GO:0045666; GO:0050774; GO:0051117; GO:0051480; GO:0051928; GO:0070301; GO:0070588; GO:0070679
GN004717	GN004717.1	Q55CU8	29.3	184	344	364	6.53e-16	81.3	PITC_DICDI	Phosphatidylinositol transfer protein 3 (CRAL-TRIO domain-containing protein pitC) (Random slug protein 5)	Dictyostelium discoideum (Social amoeba)		phosphatidylinositol transfer activity [GO:0008526]		GO:0008526
GN004720	GN004720.1	P56590	31.1	463	486	524	8.57e-76	250	CP1A1_CANLF	Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (Cytochrome P450 form 6) (Cytochrome P450-C) (Cytochrome P450-P1) (DAH1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)	Canis lupus familiaris (Dog) (Canis familiaris)	estrogen metabolic process [GO:0008210]; fatty acid metabolic process [GO:0006631]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; toxin metabolic process [GO:0009404]; xenobiotic catabolic process [GO:0042178]	arachidonate 11,12-epoxygenase activity [GO:0008405]; arachidonate 14,15-epoxygenase activity [GO:0008404]; arachidonate 8,9-epoxygenase activity [GO:0106302]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; fatty acid omega-1 hydroxylase activity [GO:0120502]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005506; GO:0005737; GO:0005739; GO:0005743; GO:0005789; GO:0006631; GO:0006706; GO:0008210; GO:0008395; GO:0008404; GO:0008405; GO:0009404; GO:0016712; GO:0020037; GO:0030544; GO:0042178; GO:0042572; GO:0051879; GO:0101020; GO:0101021; GO:0106256; GO:0106302; GO:0120502
GN004722	GN004722.1	O15995	48.0	427	440	424	1.12e-122	366	CCNE_HEMPU	G1/S-specific cyclin-E	Hemicentrotus pulcherrimus (Sea urchin) (Strongylocentrotus pulcherrimus)			nucleus [GO:0005634]	GO:0005634
GN004723	GN004723.1	Q1NZ26	58.5	171	429	277	7.45e-56	189	YSMU_CAEEL	Uncharacterized protein F13E9.13, mitochondrial	Caenorhabditis elegans			mitochondrion [GO:0005739]	GO:0005739
GN004724	GN004724.1	Q9WTK3	44.5	382	444	621	7.79e-103	322	GPAA1_MOUSE	GPI-anchor transamidase component GPAA1 (GAA1 protein homolog) (mGAA1) (Glycosylphosphatidylinositol anchor attachment 1 protein) (GPI anchor attachment protein 1)	Mus musculus (Mouse)	attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; GPI anchored protein biosynthesis [GO:0180046]	GPI anchor binding [GO:0034235]; GPI-anchor transamidase activity [GO:0003923]	centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0003923; GO:0005739; GO:0005783; GO:0005789; GO:0005813; GO:0005829; GO:0005886; GO:0006506; GO:0016255; GO:0034235; GO:0042765; GO:0180046
GN004726	GN004726.1	P00125	54.5	266	327	325	1.63e-94	286	CY1_BOVIN	Cytochrome c1, heme protein, mitochondrial (EC 7.1.1.8) (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)	Bos taurus (Bovine)	mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]	heme binding [GO:0020037]; quinol-cytochrome-c reductase activity [GO:0008121]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex III [GO:0045275]	GO:0005739; GO:0005743; GO:0006122; GO:0008121; GO:0020037; GO:0045275
GN004727	GN004727.1	P08059	72.1	476	476	558	3.96e-261	724	G6PI_PIG	Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (D-hexose-6-phosphate anomerase) (Glucose-6-phosphate C2-epimerase) (EC 5.1.3.-) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)	Sus scrofa (Pig)	canonical glycolysis [GO:0061621]; fructose 6-phosphate metabolic process [GO:0006002]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glycolytic process [GO:0006096]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of immunoglobulin production [GO:0002639]	carbohydrate derivative binding [GO:0097367]; glucose-6-phosphate 1-epimerase activity [GO:0047938]; glucose-6-phosphate isomerase activity [GO:0004347]; monosaccharide binding [GO:0048029]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]; ubiquitin protein ligase binding [GO:0031625]	ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]	GO:0002639; GO:0004347; GO:0005576; GO:0005737; GO:0005829; GO:0006002; GO:0006094; GO:0006096; GO:0010595; GO:0016857; GO:0031625; GO:0047938; GO:0048029; GO:0051156; GO:0060170; GO:0061621; GO:0097367
GN004731	GN004731.1	Q6P4M5	45.4	291	287	390	1.04e-86	267	GFOD1_XENTR	Glucose-fructose oxidoreductase domain-containing protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]	extracellular region [GO:0005576]	GO:0000166; GO:0005576; GO:0042802
GN004732	GN004732.1	P08761	44.8	181	191	246	3.45e-46	155	MSRA_DROME	Peptide methionine sulfoxide reductase (EC 1.8.4.11) (Ecdysone-induced protein 28/29 kDa) (Methionine-S-sulfoxide reductase) (Peptide-methionine (S)-S-oxide reductase)	Drosophila melanogaster (Fruit fly)	cellular response to oxidative stress [GO:0034599]; determination of adult lifespan [GO:0008340]; response to oxidative stress [GO:0006979]; sulfur amino acid metabolic process [GO:0000096]	L-methionine (S)-S-oxide reductase activity [GO:0033744]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113]	mitochondrion [GO:0005739]	GO:0000096; GO:0005739; GO:0006979; GO:0008113; GO:0008340; GO:0033744; GO:0034599
GN004733	GN004733.1	Q7TQE7	53.2	331	452	519	3.38e-121	366	MACA2_MOUSE	Putative tyrosine carboxypeptidase MATCAP2 (EC 3.4.17.-)	Mus musculus (Mouse)				
GN004734	GN004734.1	C7G3A0	44.0	134	137	391	5.89e-27	106	MPPE1_CRIGR	Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; GPI anchor biosynthetic process [GO:0006506]; GPI anchor remodelling [GO:0120574]	GPI anchor binding [GO:0034235]; GPI-mannose ethanolamine phosphate phosphodiesterase activity [GO:0062050]; manganese ion binding [GO:0030145]	endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]	GO:0005794; GO:0006506; GO:0006888; GO:0030145; GO:0033116; GO:0034235; GO:0062050; GO:0070971; GO:0120574
GN004735	GN004735.1	F4KGU4	31.7	1509	1716	1775	8.73e-213	681	DEAHC_ARATH	ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)	Arabidopsis thaliana (Mouse-ear cress)	protein targeting [GO:0006605]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]; zinc ion binding [GO:0008270]	chloroplast [GO:0009507]; endosome [GO:0005768]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0004386; GO:0005524; GO:0005634; GO:0005768; GO:0006605; GO:0008270; GO:0009507; GO:0016887
GN004736	GN004736.1	F4KGU4	31.4	1529	2856	1775	1.93e-200	667	DEAHC_ARATH	ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)	Arabidopsis thaliana (Mouse-ear cress)	protein targeting [GO:0006605]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]; zinc ion binding [GO:0008270]	chloroplast [GO:0009507]; endosome [GO:0005768]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0004386; GO:0005524; GO:0005634; GO:0005768; GO:0006605; GO:0008270; GO:0009507; GO:0016887
GN004738	GN004738.1	F4KGU4	31.8	1531	2906	1775	8.79e-209	691	DEAHC_ARATH	ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)	Arabidopsis thaliana (Mouse-ear cress)	protein targeting [GO:0006605]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]; zinc ion binding [GO:0008270]	chloroplast [GO:0009507]; endosome [GO:0005768]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0004386; GO:0005524; GO:0005634; GO:0005768; GO:0006605; GO:0008270; GO:0009507; GO:0016887
GN004741	GN004741.1	P34269	34.7	308	373	601	2.46e-50	181	TYR1_CAEEL	Putative tyrosinase-like protein tyr-1	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN004743	GN004743.1	P86952	48.0	100	582	456	6.92e-19	93.2	TYRO_PINMA	Tyrosinase-like protein (Tyrosinase-2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN004744	GN004744.1	Q19673	35.6	303	719	693	1.13e-43	171	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN004745	GN004745.1	Q8TB52	36.7	79	539	745	1.65e-09	64.3	FBX30_HUMAN	F-box only protein 30	Homo sapiens (Human)	protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005829; GO:0008270; GO:0016567; GO:0019005; GO:0031146; GO:0061630
GN004746	GN004746.1	H2A0L1	34.8	299	736	456	9.55e-44	167	TYRO2_PINMG	Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2)	Margaritifera margaritifera (Freshwater pearl mussel)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN004747	GN004747.1	P58390	39.3	420	457	574	4.98e-88	282	KCNN2_MOUSE	Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)	Mus musculus (Mouse)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; modulation of chemical synaptic transmission [GO:0050804]; monoatomic ion transport [GO:0006811]; positive regulation of potassium ion transport [GO:0043268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of potassium ion transmembrane transport [GO:1901379]	alpha-actinin binding [GO:0051393]; calcium-activated potassium channel activity [GO:0015269]; calmodulin binding [GO:0005516]; inward rectifier potassium channel activity [GO:0005242]; monoatomic ion channel activity [GO:0005216]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; small conductance calcium-activated potassium channel activity [GO:0016286]	cell surface [GO:0009986]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; smooth endoplasmic reticulum [GO:0005790]; T-tubule [GO:0030315]; Z disc [GO:0030018]	GO:0005216; GO:0005242; GO:0005516; GO:0005790; GO:0005886; GO:0006811; GO:0006813; GO:0009986; GO:0015269; GO:0016020; GO:0016286; GO:0019904; GO:0030018; GO:0030315; GO:0042383; GO:0042803; GO:0043025; GO:0043197; GO:0043268; GO:0045211; GO:0048168; GO:0050804; GO:0051393; GO:0071805; GO:0098914; GO:0098978; GO:1901379
GN004751	GN004751.1	O60308	43.1	941	897	925	5.80e-234	686	CE104_HUMAN	Centrosomal protein of 104 kDa (Cep104)	Homo sapiens (Human)		identical protein binding [GO:0042802]	centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; spindle pole [GO:0000922]	GO:0000922; GO:0005813; GO:0005814; GO:0005929; GO:0042802
GN004753	GN004753.1	O54788	42.1	214	229	344	4.57e-47	161	DFFB_MOUSE	DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (DNA fragmentation factor 40 kDa subunit) (DFF-40)	Mus musculus (Mouse)	apoptotic chromosome condensation [GO:0030263]; apoptotic DNA fragmentation [GO:0006309]; DNA catabolic process [GO:0006308]; negative regulation of apoptotic DNA fragmentation [GO:1902511]	disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA nuclease activity [GO:0004536]; enzyme binding [GO:0019899]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; nuclease activity [GO:0004518]; protein domain specific binding [GO:0019904]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000785; GO:0003677; GO:0004518; GO:0004520; GO:0004536; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0006308; GO:0006309; GO:0016787; GO:0019899; GO:0019904; GO:0030263; GO:0032991; GO:0042802; GO:0097718; GO:1902511
GN004754	GN004754.1	Q6TH22	59.2	368	348	411	1.72e-135	394	DDI2_DANRE	Protein DDI1 homolog 2 (EC 3.4.23.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to hydroxyurea [GO:0072711]; proteasomal protein catabolic process [GO:0010498]; protein processing [GO:0016485]; regulation of DNA stability [GO:0097752]; regulation of protein stability [GO:0031647]	aspartic-type endopeptidase activity [GO:0004190]; identical protein binding [GO:0042802]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004190; GO:0005694; GO:0005737; GO:0005829; GO:0010498; GO:0016485; GO:0031647; GO:0042802; GO:0072711; GO:0097752
GN004763	GN004763.1	B4LZT9	28.7	164	1348	483	6.45e-10	67.0	HH_DROVI	Protein hedgehog (EC 3.1.-.-) [Cleaved into: Protein hedgehog N-product]	Drosophila virilis (Fruit fly)	cell fate specification [GO:0001708]; cell-cell signaling [GO:0007267]; intein-mediated protein splicing [GO:0016539]; protein autoprocessing [GO:0016540]; regulation of gene expression [GO:0010468]; segment polarity determination [GO:0007367]; smoothened signaling pathway [GO:0007224]; system development [GO:0048731]	calcium ion binding [GO:0005509]; cholesterol-protein transferase activity [GO:0140853]; endopeptidase activity [GO:0004175]; patched binding [GO:0005113]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0001708; GO:0004175; GO:0005113; GO:0005509; GO:0005634; GO:0005737; GO:0005886; GO:0007224; GO:0007267; GO:0007367; GO:0010468; GO:0016539; GO:0016540; GO:0048731; GO:0140853
GN004765	GN004765.1	Q60414	32.1	302	451	348	2.14e-35	137	NTCP2_CRIGR	Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)		bile acid:sodium symporter activity [GO:0008508]	apical plasma membrane [GO:0016324]	GO:0008508; GO:0016324
GN004766	GN004766.1	Q9UK23	58.1	62	73	515	1.45e-15	72.4	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; lysosome organization [GO:0007040]; protein modification process [GO:0036211]; protein targeting to lysosome [GO:0006622]; secretion of lysosomal enzymes [GO:0033299]	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity [GO:0003944]	Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]	GO:0003944; GO:0005975; GO:0006622; GO:0007040; GO:0016020; GO:0032580; GO:0033299; GO:0036211
GN004769	GN004769.1	O35874	31.4	427	426	532	6.81e-72	238	SATT_MOUSE	Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (Solute carrier family 1 member 4)	Mus musculus (Mouse)	cognition [GO:0050890]; hydroxyproline transport [GO:0034589]; L-alanine import across plasma membrane [GO:1904273]; L-alanine transport [GO:0015808]; L-aspartate import across plasma membrane [GO:0140009]; L-cystine transport [GO:0015811]; L-glutamate transmembrane transport [GO:0015813]; L-serine import across plasma membrane [GO:1903812]; L-serine transport [GO:0015825]; proline transport [GO:0015824]; serine import across plasma membrane [GO:0098718]; threonine transport [GO:0015826]	chloride channel activity [GO:0005254]; L-alanine transmembrane transporter activity [GO:0015180]; L-aspartate transmembrane transporter activity [GO:0015183]; L-cystine transmembrane transporter activity [GO:0015184]; L-hydroxyproline transmembrane transporter activity [GO:0034590]; L-proline transmembrane transporter activity [GO:0015193]; L-serine transmembrane transporter activity [GO:0015194]; L-threonine transmembrane transporter activity [GO:0015195]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; symporter activity [GO:0015293]	centrosome [GO:0005813]; dendrite [GO:0030425]; intermediate filament [GO:0005882]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	GO:0005254; GO:0005813; GO:0005882; GO:0005886; GO:0015175; GO:0015180; GO:0015183; GO:0015184; GO:0015193; GO:0015194; GO:0015195; GO:0015293; GO:0015808; GO:0015811; GO:0015813; GO:0015824; GO:0015825; GO:0015826; GO:0016020; GO:0030425; GO:0033162; GO:0034589; GO:0034590; GO:0043025; GO:0050890; GO:0098718; GO:0140009; GO:1903812; GO:1904273
GN004772	GN004772.1	O96006	24.9	325	297	694	3.31e-21	97.1	ZBED1_HUMAN	E3 SUMO-protein ligase ZBED1 (EC 2.3.2.-) (DNA replication-related element-binding factor) (Putative Ac-like transposable element) (Zinc finger BED domain-containing protein 1) (dREF homolog)	Homo sapiens (Human)	host-mediated suppression of viral genome replication [GO:0044828]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autosumoylation [GO:1990466]; protein sumoylation [GO:0016925]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0003712; GO:0003713; GO:0005634; GO:0005654; GO:0006355; GO:0006357; GO:0016605; GO:0016925; GO:0019789; GO:0031965; GO:0042802; GO:0043565; GO:0044828; GO:0045944; GO:0046983; GO:0061665; GO:1990466; GO:1990837
GN004775	GN004775.1	P29995	21.7	2909	2803	2701	6.41e-101	369	ITPR2_RAT	Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)	Rattus norvegicus (Rat)	calcium ion transport [GO:0006816]; cellular response to cAMP [GO:0071320]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hypoxia [GO:0001666]	calcium ion binding [GO:0005509]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]; intracellularly gated calcium channel activity [GO:0015278]; phosphatidylinositol binding [GO:0035091]; scaffold protein binding [GO:0097110]; transmembrane transporter binding [GO:0044325]	axon [GO:0030424]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; secretory granule membrane [GO:0030667]; signaling receptor complex [GO:0043235]; transport vesicle membrane [GO:0030658]	GO:0001666; GO:0005220; GO:0005509; GO:0005737; GO:0005783; GO:0005789; GO:0005886; GO:0005938; GO:0006816; GO:0015278; GO:0016529; GO:0030424; GO:0030658; GO:0030667; GO:0033017; GO:0035091; GO:0043235; GO:0044325; GO:0051209; GO:0070679; GO:0071320; GO:0071361; GO:0071456; GO:0097110
GN004776	GN004776.1	Q3SZH6	50.9	548	592	461	7.47e-190	544	TTLL9_BOVIN	Probable tubulin polyglutamylase TTLL9 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 9)	Bos taurus (Bovine)	microtubule cytoskeleton organization [GO:0000226]	ATP binding [GO:0005524]; protein-glutamic acid ligase activity, elongating [GO:0106438]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	ciliary basal body [GO:0036064]	GO:0000226; GO:0005524; GO:0015631; GO:0036064; GO:0070740; GO:0106438
GN004777	GN004777.1	Q28FE8	38.0	527	528	472	3.47e-96	303	ADAT1_XENTR	tRNA-specific adenosine deaminase 1 (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	tRNA processing [GO:0008033]	RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251]; tRNA-specific adenosine-37 deaminase activity [GO:0043829]		GO:0003723; GO:0008033; GO:0008251; GO:0043829
GN004778	GN004778.1	Q13523	73.8	389	1061	1007	1.79e-189	579	PRP4K_HUMAN	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)	Homo sapiens (Human)	mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of hippo signaling [GO:0035332]; positive regulation of protein export from nucleus [GO:0046827]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [GO:0000388]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; kinetochore [GO:0000776]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type precatalytic spliceosome [GO:0071016]	GO:0000244; GO:0000387; GO:0000388; GO:0000398; GO:0000776; GO:0003723; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0016607; GO:0035332; GO:0045292; GO:0046827; GO:0071013; GO:0071016; GO:0090266; GO:0106310
GN004779	GN004779.1	Q8SPE9	29.4	272	878	828	2.61e-18	94.0	TLR4_PONPY	Toll-like receptor 4 (CD antigen CD284)	Pongo pygmaeus (Bornean orangutan)	defense response to Gram-negative bacterium [GO:0050829]; detection of lipopolysaccharide [GO:0032497]; immune response [GO:0006955]; inflammatory response [GO:0006954]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of tumor necrosis factor production [GO:0032680]; toll-like receptor 4 signaling pathway [GO:0034142]	lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; transmembrane signaling receptor activity [GO:0004888]	early endosome [GO:0005769]; lipopolysaccharide receptor complex [GO:0046696]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GO:0001530; GO:0001726; GO:0001875; GO:0002755; GO:0004888; GO:0005769; GO:0005886; GO:0006954; GO:0006955; GO:0032497; GO:0032680; GO:0032731; GO:0034142; GO:0042116; GO:0046696; GO:0050829; GO:1900227
GN004780	GN004780.1	Q0PV50	27.0	204	327	904	5.88e-14	76.3	TLR3_BOSTR	Toll-like receptor 3 (CD antigen CD283)	Boselaphus tragocamelus (Nilgai)	defense response to virus [GO:0051607]; inflammatory response to wounding [GO:0090594]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; response to exogenous dsRNA [GO:0043330]; toll-like receptor signaling pathway [GO:0002224]	pattern recognition receptor activity [GO:0038187]; transmembrane signaling receptor activity [GO:0004888]	early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	GO:0002224; GO:0004888; GO:0005769; GO:0005789; GO:0005886; GO:0010008; GO:0032722; GO:0032728; GO:0032755; GO:0035556; GO:0038187; GO:0043123; GO:0043330; GO:0045087; GO:0046330; GO:0051607; GO:0090594
GN004781	GN004781.1	Q7TQ62	25.2	353	392	611	7.46e-11	67.4	PODN_MOUSE	Podocan	Mus musculus (Mouse)	negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]	collagen binding [GO:0005518]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; gel phase of interstitial matrix [GO:0140150]	GO:0005518; GO:0005576; GO:0005737; GO:0008285; GO:0030336; GO:0140150
GN004782	GN004782.1	Q7TQ62	27.3	359	868	611	1.50e-20	100	PODN_MOUSE	Podocan	Mus musculus (Mouse)	negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]	collagen binding [GO:0005518]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; gel phase of interstitial matrix [GO:0140150]	GO:0005518; GO:0005576; GO:0005737; GO:0008285; GO:0030336; GO:0140150
GN004786	GN004786.1	Q5TZA2	38.2	589	2132	2017	3.58e-69	263	CROCC_HUMAN	Rootletin (Ciliary rootlet coiled-coil protein)	Homo sapiens (Human)	centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098]; intracellular protein localization [GO:0008104]; positive regulation of cilium assembly [GO:0045724]; positive regulation of protein localization to cilium [GO:1903566]	actin binding [GO:0003779]; kinesin binding [GO:0019894]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]	9+2 motile cilium [GO:0097729]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; extracellular exosome [GO:0070062]; photoreceptor inner segment [GO:0001917]; subapical part of cell [GO:0120219]	GO:0001917; GO:0003779; GO:0005198; GO:0005200; GO:0005813; GO:0005814; GO:0007098; GO:0008104; GO:0010457; GO:0019894; GO:0035253; GO:0036064; GO:0045724; GO:0070062; GO:0097729; GO:0120219; GO:1903566
GN004787	GN004787.1	P31029	55.9	376	426	414	1.91e-148	431	AGT1_CALJA	Alanine--glyoxylate aminotransferase (AGT) (EC 2.6.1.44) (Serine--pyruvate aminotransferase, mitochondrial) (SPT) (EC 2.6.1.51)	Callithrix jacchus (White-tufted-ear marmoset) (Simia Jacchus)	glyoxylate metabolic process [GO:0046487]	L-alanine:glyoxylate transaminase activity [GO:0008453]; L-serine:pyruvate transaminase activity [GO:0004760]; protein homodimerization activity [GO:0042803]	mitochondrial matrix [GO:0005759]; peroxisome [GO:0005777]	GO:0004760; GO:0005759; GO:0005777; GO:0008453; GO:0042803; GO:0046487
GN004788	GN004788.1	O15013	30.8	854	1574	1369	6.98e-104	367	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; centrosome duplication [GO:0051298]; mitotic spindle assembly [GO:0090307]; myelination in peripheral nervous system [GO:0022011]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; regulation of small GTPase mediated signal transduction [GO:0051056]	guanyl-nucleotide exchange factor activity [GO:0005085]; kinesin binding [GO:0019894]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005085; GO:0005737; GO:0005813; GO:0005829; GO:0019894; GO:0022011; GO:0030036; GO:0035025; GO:0051056; GO:0051298; GO:0051496; GO:0090307
GN004791	GN004791.1	P56399	55.0	856	798	858	0.0	926	UBP5_MOUSE	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)	Mus musculus (Mouse)	negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; protein K48-linked deubiquitination [GO:0071108]; regulation of mitotic cell cycle [GO:0007346]; regulation protein catabolic process at presynapse [GO:0140251]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; presynapse [GO:0098793]	GO:0002841; GO:0004843; GO:0005634; GO:0005737; GO:0007346; GO:0008270; GO:0010494; GO:0032435; GO:0032436; GO:0043130; GO:0045727; GO:0045944; GO:0050868; GO:0071108; GO:0098793; GO:0101005; GO:0140251; GO:2000059
GN004793	GN004793.1	Q8IWY8	29.2	161	306	852	3.81e-09	61.2	ZSC29_HUMAN	Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690)	Homo sapiens (Human)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:1990837
GN004798	GN004798.1	Q9M2U3	30.0	220	248	406	1.77e-22	98.2	ALPL_ARATH	Protein ALP1-like (EC 3.1.-.-)	Arabidopsis thaliana (Mouse-ear cress)			histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634
GN004801	GN004801.1	Q9VPQ6	23.2	896	1228	1191	3.10e-26	120	USH_DROME	Zinc finger protein ush (Protein U-shaped)	Drosophila melanogaster (Fruit fly)	amnioserosa maintenance [GO:0046665]; cell differentiation [GO:0030154]; chaeta development [GO:0022416]; compound eye development [GO:0048749]; germ-band shortening [GO:0007390]; heart development [GO:0007507]; larval lymph gland hemopoiesis [GO:0035167]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; lymph gland plasmatocyte differentiation [GO:0035169]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hemocyte differentiation [GO:0045611]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of antibacterial peptide biosynthetic process [GO:0006963]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription repressor activity [GO:0001217]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]	GO:0000122; GO:0001217; GO:0003714; GO:0005634; GO:0006355; GO:0006963; GO:0007390; GO:0007507; GO:0022416; GO:0030154; GO:0035167; GO:0035169; GO:0035170; GO:0045611; GO:0045892; GO:0045944; GO:0046627; GO:0046665; GO:0048542; GO:0048749; GO:0061629
GN004802	GN004802.1	Q9NY26	31.1	315	317	324	6.68e-27	110	S39A1_HUMAN	Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1)	Homo sapiens (Human)	monoatomic cation transport [GO:0006812]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	signaling receptor binding [GO:0005102]; transmembrane transporter activity [GO:0022857]; zinc ion transmembrane transporter activity [GO:0005385]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005102; GO:0005385; GO:0005789; GO:0005886; GO:0006812; GO:0016020; GO:0022857; GO:0071577; GO:0071578
GN004803	GN004803.1	O94983	29.1	1278	1311	1202	1.42e-89	320	CMTA2_HUMAN	Calmodulin-binding transcription activator 2	Homo sapiens (Human)	cardiac muscle hypertrophy in response to stress [GO:0014898]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0003682; GO:0003712; GO:0003713; GO:0005634; GO:0005654; GO:0006357; GO:0014898; GO:0042826; GO:0043565; GO:0045944
GN004806	GN004806.1	Q9YHY6	43.2	1348	1434	1364	0.0	1004	CND1_XENLA	Condensin complex subunit 1 (Chromosome assembly protein XCAP-D2) (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (Eg7) (Non-SMC condensin I complex subunit D2)	Xenopus laevis (African clawed frog)	meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]	histone binding [GO:0042393]	condensed chromosome, centromeric region [GO:0000779]; condensin complex [GO:0000796]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000779; GO:0000796; GO:0005634; GO:0005829; GO:0007076; GO:0010032; GO:0042393
GN004807	GN004807.1	A0A2P1DP94	30.0	140	191	536	6.00e-13	69.7	MACC_PENTR	Cytochrome P450 monooxygenase macC (EC 1.-.-.-) (Macrophorins biosynthesis cluster protein C)	Penicillium terrestre	mycotoxin biosynthetic process [GO:0043386]; terpenoid biosynthetic process [GO:0016114]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	membrane [GO:0016020]	GO:0004497; GO:0005506; GO:0016020; GO:0016114; GO:0016705; GO:0020037; GO:0043386
GN004808	GN004808.1	P05185	38.3	175	178	509	4.67e-34	128	CP17A_BOVIN	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)	Bos taurus (Bovine)	glucocorticoid biosynthetic process [GO:0006704]; hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid metabolic process [GO:0008202]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	endoplasmic reticulum membrane [GO:0005789]	GO:0004508; GO:0005506; GO:0005789; GO:0006704; GO:0008202; GO:0020037; GO:0042446; GO:0042448
GN004809	GN004809.1	A8NCK6	34.9	83	189	526	2.62e-12	67.8	COX2_COPC7	Cytochrome P450 monooxygenase COX2 (EC 1.-.-.-) (Alpha-cuprenene oxidase 2)	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)		heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	membrane [GO:0016020]	GO:0004497; GO:0005506; GO:0016020; GO:0016705; GO:0020037
GN004810	GN004810.1	Q29497	26.4	489	474	509	2.36e-46	171	CP17A_SHEEP	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)	Ovis aries (Sheep)	glucocorticoid biosynthetic process [GO:0006704]; hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid metabolic process [GO:0008202]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	endoplasmic reticulum membrane [GO:0005789]	GO:0004508; GO:0005506; GO:0005789; GO:0006704; GO:0008202; GO:0020037; GO:0042446; GO:0042448
GN004811	GN004811.1	Q3MHP5	83.5	352	402	367	1.92e-214	595	DRG1_BOVIN	Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-)	Bos taurus (Bovine)	cytoplasmic translation [GO:0002181]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic spindle assembly [GO:1901673]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0002181; GO:0003924; GO:0005525; GO:0005634; GO:0005737; GO:0008017; GO:0031116; GO:1901673
GN004813	GN004813.1	Q9NQG7	30.9	194	586	708	2.23e-11	70.5	HPS4_HUMAN	BLOC-3 complex member HPS4 (Hermansky-Pudlak syndrome 4 protein) (Light-ear protein homolog)	Homo sapiens (Human)	hemostasis [GO:0007599]; lysosome organization [GO:0007040]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; positive regulation of eye pigmentation [GO:0048075]; positive regulation of protein localization to mitochondrion [GO:1903749]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192]	protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]	BLOC-3 complex [GO:0031085]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; platelet dense granule [GO:0042827]	GO:0005737; GO:0005764; GO:0005765; GO:0005829; GO:0006605; GO:0007040; GO:0007599; GO:0016020; GO:0016192; GO:0031085; GO:0031267; GO:0031410; GO:0042470; GO:0042803; GO:0042827; GO:0046983; GO:0048075; GO:0050821; GO:0060155; GO:1903232; GO:1903749
GN004817	GN004817.1	Q14839	73.0	363	360	1912	1.11e-159	494	CHD4_HUMAN	ATP-dependent chromatin remodeler CHD4 (EC 3.6.4.-) (Chromo domain-containing protein 4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]; regulation of synapse assembly [GO:0051963]; terminal button organization [GO:0072553]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cerebellar granule cell to Purkinje cell synapse [GO:0150048]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; site of DNA damage [GO:0090734]	GO:0000122; GO:0000724; GO:0000781; GO:0000785; GO:0001221; GO:0003677; GO:0003682; GO:0003714; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0006338; GO:0008270; GO:0010629; GO:0016020; GO:0016581; GO:0016887; GO:0032991; GO:0032993; GO:0042393; GO:0042659; GO:0042826; GO:0045892; GO:0045893; GO:0051963; GO:0061629; GO:0072553; GO:0090575; GO:0090734; GO:0140658; GO:0150048; GO:2000736
GN004818	GN004818.1	A1A5V9	27.4	226	227	296	1.37e-23	99.0	ELP5_DANRE	Elongator complex protein 5 (Dermal papilla-derived protein 6 homolog) (Retinoic acid-induced protein 12)	Danio rerio (Zebrafish) (Brachydanio rerio)	positive regulation of cell migration [GO:0030335]; tRNA modification [GO:0006400]; tRNA wobble uridine modification [GO:0002098]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634]	GO:0002098; GO:0005634; GO:0005737; GO:0005829; GO:0006400; GO:0030335; GO:0033588
GN004819	GN004819.1	Q9CR24	50.6	174	268	210	1.37e-49	165	NUDT8_MOUSE	Mitochondrial coenzyme A diphosphatase NUDT8 (EC 3.6.1.-) (EC 3.6.1.77) (Nucleoside diphosphate-linked moiety X motif 8) (Nudix motif 8)	Mus musculus (Mouse)	acetyl-CoA catabolic process [GO:0046356]; butyryl-CoA catabolic process [GO:0044580]; coenzyme A catabolic process [GO:0015938]; malonyl-CoA catabolic process [GO:2001294]; medium-chain fatty-acyl-CoA catabolic process [GO:0036114]; propionyl-CoA catabolic process [GO:1902859]; succinyl-CoA catabolic process [GO:1901289]	coenzyme A diphosphatase activity [GO:0010945]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0000287; GO:0005739; GO:0005759; GO:0010945; GO:0015938; GO:0030145; GO:0036114; GO:0044580; GO:0046356; GO:1901289; GO:1902859; GO:2001294
GN004820	GN004820.1	Q08C33	54.2	190	195	283	1.19e-69	216	ISOC1_DANRE	Isochorismatase domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]	GO:0005737
GN004822	GN004822.1	P37287	63.9	418	443	484	2.65e-182	520	PIGA_HUMAN	Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (EC 2.4.1.198) (GlcNAc-PI synthesis protein) (Phosphatidylinositol-glycan biosynthesis class A protein) (PIG-A)	Homo sapiens (Human)	GPI anchor biosynthetic process [GO:0006506]	phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176]; UDP-glycosyltransferase activity [GO:0008194]	endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; membrane [GO:0016020]; rough endoplasmic reticulum membrane [GO:0030867]	GO:0000506; GO:0005789; GO:0006506; GO:0008194; GO:0016020; GO:0017176; GO:0030867
GN004823	GN004823.1	Q09225	41.8	91	164	822	3.18e-11	63.9	NRF6_CAEEL	Nose resistant to fluoxetine protein 6 (Protein nrf-6)	Caenorhabditis elegans		acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]	membrane [GO:0016020]	GO:0016020; GO:0016747
GN004824	GN004824.1	Q63931	25.5	361	359	430	1.04e-09	63.2	CCKAR_CAVPO	Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R)	Cavia porcellus (Guinea pig)		cholecystokinin receptor activity [GO:0004951]; neuropeptide receptor activity [GO:0008188]; peptide hormone binding [GO:0017046]	plasma membrane [GO:0005886]	GO:0004951; GO:0005886; GO:0008188; GO:0017046
GN004833	GN004833.1	Q9Y2C3	32.7	254	297	310	1.87e-35	132	B3GT5_HUMAN	Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)	Homo sapiens (Human)	glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005783; GO:0005794; GO:0008499; GO:0009101; GO:0009312
GN004835	GN004835.1	P62869	70.2	104	115	118	5.07e-41	134	ELOB_MOUSE	Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2)	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; target-directed miRNA degradation [GO:0140958]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; elongin complex [GO:0070449]; transcription regulator complex [GO:0005667]; VCB complex [GO:0030891]	GO:0001222; GO:0003713; GO:0005667; GO:0005829; GO:0006367; GO:0006368; GO:0016567; GO:0030891; GO:0031462; GO:0031466; GO:0031625; GO:0044877; GO:0045944; GO:0070449; GO:0140627; GO:0140958
GN004836	GN004836.1	Q9WVS8	47.8	513	997	806	8.46e-133	423	MK07_MOUSE	Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)	Mus musculus (Mouse)	cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ERK5 cascade [GO:0070375]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of ERK5 cascade [GO:0070377]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of angiogenesis [GO:0045765]	ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; mitogen-activated protein kinase binding [GO:0051019]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0000165; GO:0004672; GO:0004674; GO:0004707; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006468; GO:0016605; GO:0018105; GO:0034115; GO:0034392; GO:0035556; GO:0043066; GO:0043407; GO:0045765; GO:0045944; GO:0046777; GO:0051019; GO:0051247; GO:0060761; GO:0070301; GO:0070375; GO:0070377; GO:0070885; GO:0071363; GO:0071499; GO:0071560; GO:0106310; GO:1902176; GO:2000352; GO:2001240
GN004840	GN004840.1	Q9H0C1	62.5	152	156	365	1.71e-56	183	ZMY12_HUMAN	Zinc finger MYND domain-containing protein 12	Homo sapiens (Human)	flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288]; sperm capacitation [GO:0048240]		sperm flagellum [GO:0036126]	GO:0007288; GO:0030317; GO:0036126; GO:0048240
GN004846	GN004846.1	Q8K4P0	65.1	393	1106	1330	9.66e-173	546	WDR33_MOUSE	pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa)	Mus musculus (Mouse)	mRNA 3'-end processing [GO:0031124]		fibrillar center [GO:0001650]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001650; GO:0005634; GO:0005654; GO:0005847; GO:0031124
GN004847	GN004847.1	Q17N71	61.4	1315	1316	1442	0.0	1567	CLU_AEDAE	Clustered mitochondria protein homolog	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	intracellular distribution of mitochondria [GO:0048312]; mitochondrion organization [GO:0007005]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]	GO:0003729; GO:0005737; GO:0007005; GO:0048312
GN004848	GN004848.1	P09487	47.5	482	501	524	7.05e-141	418	PPBT_BOVIN	Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1)	Bos taurus (Bovine)	biomineral tissue development [GO:0031214]; bone mineralization [GO:0030282]; positive regulation of cold-induced thermogenesis [GO:0120162]	5'-nucleotidase activity [GO:0008253]; ADP phosphatase activity [GO:0043262]; alkaline phosphatase activity [GO:0004035]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; inorganic diphosphate phosphatase activity [GO:0004427]; phosphoamidase activity [GO:0050187]; phosphoethanolamine phosphatase activity [GO:0052732]; pyridoxal phosphatase activity [GO:0033883]; pyrophosphatase activity [GO:0016462]	extracellular membrane-bounded organelle [GO:0065010]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	GO:0004035; GO:0004427; GO:0005509; GO:0005758; GO:0005886; GO:0008253; GO:0016462; GO:0016887; GO:0030282; GO:0031214; GO:0031966; GO:0033883; GO:0043262; GO:0050187; GO:0052732; GO:0065010; GO:0120162
GN004849	GN004849.1	P49916	52.3	960	942	1009	0.0	928	DNLI3_HUMAN	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)	Homo sapiens (Human)	base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA biosynthetic process [GO:0071897]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; lagging strand elongation [GO:0006273]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial DNA replication [GO:0090298]; regulation of DNA repair [GO:0006282]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; DNA ligase activity [GO:0003909]; zinc ion binding [GO:0008270]	DNA ligase III-XRCC1 complex [GO:0070421]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0000724; GO:0003677; GO:0003909; GO:0003910; GO:0005524; GO:0005634; GO:0005654; GO:0005739; GO:0005759; GO:0006273; GO:0006282; GO:0006284; GO:0006287; GO:0006302; GO:0007005; GO:0008270; GO:0043504; GO:0070421; GO:0071897; GO:0090298; GO:0090734; GO:0097681
GN004850	GN004850.1	A1Z6E0	72.3	235	237	279	3.24e-128	366	GUS_DROME	Protein gustavus	Drosophila melanogaster (Fruit fly)	cuticle pattern formation [GO:0035017]; dorsal appendage formation [GO:0046843]; germ cell development [GO:0007281]; germ cell migration [GO:0008354]; intracellular protein localization [GO:0008104]; intracellular signal transduction [GO:0035556]; oocyte anterior/posterior axis specification [GO:0007314]; pole plasm assembly [GO:0007315]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; wing disc morphogenesis [GO:0007472]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	cell cortex [GO:0005938]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; elongin complex [GO:0070449]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; pole plasm [GO:0045495]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005634; GO:0005737; GO:0005938; GO:0007281; GO:0007314; GO:0007315; GO:0007472; GO:0008104; GO:0008354; GO:0019005; GO:0031466; GO:0035017; GO:0035556; GO:0043161; GO:0045495; GO:0045732; GO:0046843; GO:0048471; GO:0070449; GO:1990756
GN004852	GN004852.1	Q5ZIJ9	41.8	400	1312	954	9.07e-90	316	MIB2_CHICK	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (RING-type E3 ubiquitin transferase MIB2)	Gallus gallus (Chicken)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN004853	GN004853.1	Q90VV1	40.9	110	275	277	9.74e-17	81.3	HES4B_XENLA	Transcription factor HES-4-B (Hairy and enhancer of split 4-B) (Protein hairy-2) (Xhairy2) (Protein hairy-2a) (Xhairy2b)	Xenopus laevis (African clawed frog)	anterior/posterior pattern specification [GO:0009952]; floor plate development [GO:0033504]; lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest formation [GO:0014029]; prechordal plate formation [GO:0021501]; regulation of neurogenesis [GO:0050767]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0002088; GO:0005634; GO:0009952; GO:0014029; GO:0021501; GO:0033504; GO:0043066; GO:0043565; GO:0045892; GO:0046982; GO:0048642; GO:0050767
GN004857	GN004857.1	Q32NG0	26.9	670	692	586	1.24e-46	177	ADAD1_XENLA	Adenosine deaminase domain-containing protein 1	Xenopus laevis (African clawed frog)	adenosine to inosine editing [GO:0006382]; RNA processing [GO:0006396]; spermatid development [GO:0007286]	double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; tRNA-specific adenosine deaminase activity [GO:0008251]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003725; GO:0003726; GO:0005634; GO:0005730; GO:0005737; GO:0006382; GO:0006396; GO:0007286; GO:0008251
GN004861	GN004861.1	Q8N2E2	22.3	647	819	1590	9.77e-18	92.4	VWDE_HUMAN	von Willebrand factor D and EGF domain-containing protein	Homo sapiens (Human)		signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]	GO:0005102; GO:0005576; GO:0009986
GN004863	GN004863.1	Q587J7	31.0	697	2066	1177	1.39e-93	335	TDR12_HUMAN	Putative ATP-dependent RNA helicase TDRD12 (EC 3.6.4.13) (ES cell-associated transcript 8 protein) (Tudor domain-containing protein 12)	Homo sapiens (Human)	fertilization [GO:0009566]; germ-line stem cell division [GO:0042078]; male meiotic nuclear division [GO:0007140]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	PET complex [GO:1990923]	GO:0003676; GO:0003724; GO:0005524; GO:0007140; GO:0007283; GO:0009566; GO:0016887; GO:0034587; GO:0042078; GO:0141196; GO:1990923
GN004864	GN004864.1	Q99547	43.2	155	156	160	8.90e-26	99.0	MPH6_HUMAN	M-phase phosphoprotein 6	Homo sapiens (Human)	maturation of 5.8S rRNA [GO:0000460]		cytoplasm [GO:0005737]; exosome (RNase complex) [GO:0000178]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000178; GO:0000460; GO:0005634; GO:0005654; GO:0005730; GO:0005737
GN004866	GN004866.1	P21894	61.9	969	965	967	0.0	1224	SYAC_BOMMO	Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)	Bombyx mori (Silk moth)	alanyl-tRNA aminoacylation [GO:0006419]	alanine-tRNA ligase activity [GO:0004813]; aminoacyl-tRNA deacylase activity [GO:0002161]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	mitochondrion [GO:0005739]	GO:0002161; GO:0003676; GO:0004813; GO:0005524; GO:0005739; GO:0006419; GO:0008270
GN004868	GN004868.1	P0DW91	58.6	304	345	410	1.71e-134	392	ZTRF1_BOVIN	Zinc finger TRAF-type-containing protein 1 (Cysteine and histidine-rich protein 1)	Bos taurus (Bovine)			perinuclear region of cytoplasm [GO:0048471]	GO:0048471
GN004869	GN004869.1	Q866D2	31.3	288	338	365	1.28e-41	151	FUT1_LEOFU	Galactoside alpha-(1,2)-fucosyltransferase 1 (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.344)	Leontocebus fuscicollis (Brown-mantled tamarin) (Saguinus fuscicollis)	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; olfactory bulb development [GO:0021772]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion [GO:1904906]; positive regulation of sprouting angiogenesis [GO:1903672]	alpha-(1,2)-fucosyltransferase activity [GO:0031127]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]	Golgi cisterna membrane [GO:0032580]	GO:0001954; GO:0005975; GO:0008107; GO:0009101; GO:0010595; GO:0021772; GO:0031127; GO:0032580; GO:1903672; GO:1904906
GN004871	GN004871.1	W6YKT9	28.9	270	680	644	9.42e-20	97.4	PGH_COCC2	Polyglycine hydrolase (EC 3.4.21.-) (Chitinase modifying protein) (BzCMP)	Cochliobolus carbonum (strain 26-R-13) (Maize leaf spot fungus) (Bipolaris zeicola)	effector-mediated suppression of host defense response [GO:0140590]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]	GO:0004252; GO:0005576; GO:0140590
GN004873	GN004873.1	Q641F3	34.0	156	161	957	1.12e-17	82.4	COLA1_XENLA	Collagen alpha-1(XXI) chain	Xenopus laevis (African clawed frog)			cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]	GO:0005737; GO:0031012
GN004878	GN004878.1	Q9VVY3	47.0	219	450	681	9.77e-50	182	GBS76_DROME	Glycogen-binding subunit 76A (CBM21 domain-containing protein CG9619)	Drosophila melanogaster (Fruit fly)	negative regulation of glycogen catabolic process [GO:0045818]; positive regulation of glycogen biosynthetic process [GO:0045725]; regulation of glycogen biosynthetic process [GO:0005979]	glycogen binding [GO:2001069]; protein phosphatase 1 binding [GO:0008157]	protein phosphatase type 1 complex [GO:0000164]	GO:0000164; GO:0005979; GO:0008157; GO:0045725; GO:0045818; GO:2001069
GN004883	GN004883.1	Q8CJF7	33.3	1125	2506	2243	4.07e-171	588	ELYS_MOUSE	Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1)	Mus musculus (Mouse)	hemopoiesis [GO:0030097]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; regulation of cytokinesis [GO:0032465]		chromatin [GO:0000785]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000776; GO:0000785; GO:0005634; GO:0005635; GO:0005643; GO:0005654; GO:0005737; GO:0006913; GO:0016363; GO:0016604; GO:0030097; GO:0031080; GO:0031965; GO:0032465; GO:0051292
GN004885	GN004885.1	Q8N556	22.6	390	1073	730	6.96e-10	67.0	AFAP1_HUMAN	Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110)	Homo sapiens (Human)	regulation of signal transduction [GO:0009966]	molecular adaptor activity [GO:0060090]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	GO:0001725; GO:0005829; GO:0005884; GO:0005886; GO:0005925; GO:0009966; GO:0015629; GO:0060090
GN004888	GN004888.1	Q9CWL8	58.9	95	96	563	4.66e-29	111	CTBL1_MOUSE	Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP)	Mus musculus (Mouse)	apoptotic process [GO:0006915]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of apoptotic process [GO:0043065]; somatic diversification of immunoglobulins [GO:0016445]	enzyme binding [GO:0019899]	centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]	GO:0000398; GO:0000974; GO:0005634; GO:0005654; GO:0005681; GO:0005813; GO:0005829; GO:0006915; GO:0016445; GO:0019899; GO:0043065
GN004889	GN004889.1	A8E534	50.4	363	366	406	4.54e-124	366	KDM8_DANRE	Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5)	Danio rerio (Zebrafish) (Brachydanio rerio)	circadian regulation of gene expression [GO:0032922]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; protein destabilization [GO:0031648]	chromatin binding [GO:0003682]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; peptidyl-arginine 3-dioxygenase activity [GO:0106157]	nucleus [GO:0005634]	GO:0000086; GO:0003682; GO:0005634; GO:0031648; GO:0032922; GO:0045892; GO:0045893; GO:0051864; GO:0106157; GO:0140680
GN004890	GN004890.1	Q8IY22	50.2	279	315	773	1.59e-86	278	CMIP_HUMAN	C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip)	Homo sapiens (Human)			cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829
GN004891	GN004891.1	Q9H0A9	41.0	166	194	340	1.90e-27	108	SPC1L_HUMAN	Speriolin-like protein (Spermatogenesis and centriole-associated protein 1-like protein)	Homo sapiens (Human)	spermatogenesis [GO:0007283]	identical protein binding [GO:0042802]; protein kinase A regulatory subunit binding [GO:0034237]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; sperm head-tail coupling apparatus [GO:0120212]	GO:0005737; GO:0005813; GO:0007283; GO:0034237; GO:0042802; GO:0120212
GN004895	GN004895.1	Q8NDN9	60.9	530	531	531	1.27e-248	694	RCBT1_HUMAN	RCC1 and BTB domain-containing protein 1 (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein) (Regulator of chromosome condensation and BTB domain-containing protein 1)	Homo sapiens (Human)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN004899	GN004899.1	Q13425	48.1	162	169	540	9.54e-42	149	SNTB2_HUMAN	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL)	Homo sapiens (Human)		RNA binding [GO:0003723]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658]	GO:0003723; GO:0005198; GO:0005737; GO:0005856; GO:0005886; GO:0005925; GO:0016010; GO:0016020; GO:0030658; GO:0032991; GO:0045202
GN004900	GN004900.1	Q4R930	64.4	146	182	163	5.63e-60	187	AR2BP_MACFA	ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	maintenance of protein location in nucleus [GO:0051457]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]	transcription coactivator activity [GO:0003713]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; midbody [GO:0030496]; mitochondrial intermembrane space [GO:0005758]; nucleoplasm [GO:0005654]; spindle [GO:0005819]	GO:0003713; GO:0005654; GO:0005758; GO:0005813; GO:0005819; GO:0030496; GO:0036064; GO:0042531; GO:0051457
GN004901	GN004901.1	Q9JK84	73.0	152	225	382	7.89e-69	218	PAR6G_MOUSE	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A)	Mus musculus (Mouse)	centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; regulation of cellular localization [GO:0060341]		apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0005634; GO:0005923; GO:0005938; GO:0007098; GO:0007163; GO:0016324; GO:0032991; GO:0060341
GN004902	GN004902.1	Q2YDM5	41.0	183	205	216	7.00e-37	130	SMIP8_BOVIN	Sperm microtubule inner protein 8 (Testis, prostate and placenta-expressed protein)	Bos taurus (Bovine)	flagellated sperm motility [GO:0030317]		axonemal A tubule inner sheath [GO:0160111]; sperm flagellum [GO:0036126]	GO:0030317; GO:0036126; GO:0160111
GN004904	GN004904.1	Q9W707	85.7	126	395	372	1.97e-71	231	FXF1B_XENLA	Forkhead box protein F1-B (FoxF1-B) (FoxF1b) (Fork head domain-related protein 13') (xFD-13')	Xenopus laevis (African clawed frog)	animal organ morphogenesis [GO:0009887]; BMP signaling pathway [GO:0030509]; embryonic digestive tract development [GO:0048566]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; smooth muscle tissue development [GO:0048745]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0006357; GO:0009887; GO:0030509; GO:0045893; GO:0048566; GO:0048745
GN004905	GN004905.1	A2VE54	33.2	464	654	457	4.69e-69	235	UN93A_BOVIN	N-acetylglucosamine transporter UNC93A (Protein unc-93 homolog A) (Unc-93A)	Bos taurus (Bovine)		N-acetylglucosamine transmembrane transporter activity [GO:0015572]	plasma membrane [GO:0005886]	GO:0005886; GO:0015572
GN004906	GN004906.1	Q5XLR4	27.5	218	308	276	1.12e-09	61.6	BORE1_DANRE	Borealin (Cell division cycle-associated protein 8) (Dasra-B) (DasraB) (DrDasraB)	Danio rerio (Zebrafish) (Brachydanio rerio)	heart development [GO:0007507]; mitotic sister chromatid segregation [GO:0000070]		chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]; spindle midzone [GO:0051233]	GO:0000070; GO:0000775; GO:0005634; GO:0007507; GO:0032133; GO:0051233
GN004907	GN004907.1	Q8VCC1	38.3	261	256	269	1.64e-50	169	PGDH_MOUSE	15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Eicosanoid/docosanoid dehydrogenase [NAD(+)]) (EC 1.1.1.-, EC 1.1.1.232) (Prostaglandin dehydrogenase 1)	Mus musculus (Mouse)	ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; kidney development [GO:0001822]; lipoxin biosynthetic process [GO:2001301]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; positive regulation of apoptotic process [GO:0043065]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostaglandin catabolic process [GO:1905344]; prostaglandin metabolic process [GO:0006693]; regulation of prostaglandin catabolic process [GO:1905828]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; thrombin-activated receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179]	15-hydroxyicosatetraenoate dehydrogenase activity [GO:0047034]; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity [GO:0016404]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E receptor activity [GO:0004957]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]	GO:0001822; GO:0004957; GO:0005576; GO:0005654; GO:0005737; GO:0005829; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016323; GO:0016404; GO:0016616; GO:0030728; GO:0032355; GO:0032496; GO:0042802; GO:0043065; GO:0045471; GO:0045786; GO:0047034; GO:0051287; GO:0070403; GO:0070493; GO:0097070; GO:1904707; GO:1905344; GO:1905828; GO:2001301
GN004908	GN004908.1	Q1JQ93	77.8	45	69	260	1.12e-18	79.3	DPM1_BOVIN	Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) (Dolichol-phosphate mannose synthase subunit 1) (DPM synthase subunit 1) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 1) (Mannose-P-dolichol synthase subunit 1) (MPD synthase subunit 1)	Bos taurus (Bovine)	dolichol phosphate mannose biosynthetic process [GO:0180047]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; dolichyl monophosphate biosynthetic process [GO:0043048]; GPI anchor biosynthetic process [GO:0006506]; protein O-linked glycosylation via mannose [GO:0035269]	dolichyl-phosphate beta-D-mannosyltransferase activity [GO:0004582]; metal ion binding [GO:0046872]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0004582; GO:0005783; GO:0005789; GO:0006488; GO:0006506; GO:0035269; GO:0043048; GO:0046872; GO:0180047
GN004912	GN004912.1	Q62985	78.5	107	251	756	6.57e-51	180	SH2B1_RAT	SH2B adapter protein 1 (FceRI gamma-chain-interacting protein SH2-B) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)	Rattus norvegicus (Rat)	cell motility [GO:0048870]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of DNA biosynthetic process [GO:2000278]	transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005068; GO:0005634; GO:0005829; GO:0005886; GO:0030032; GO:0035556; GO:0045840; GO:0048870; GO:0060391; GO:2000278
GN004945	GN004945.1	Q3USH5	41.8	488	841	945	1.15e-77	274	SFSWA_MOUSE	Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog)	Mus musculus (Mouse)	alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA 5'-splice site recognition [GO:0000395]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]	RNA binding [GO:0003723]	nucleus [GO:0005634]	GO:0000380; GO:0000395; GO:0003723; GO:0005634; GO:0048025
GN004951	GN004951.1	P34586	32.2	457	544	1027	1.66e-55	204	TRPL_CAEEL	Transient-receptor-potential-like protein (TRP homologous cation channel protein 1)	Caenorhabditis elegans	calcium ion transmembrane transport [GO:0070588]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338]	inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]	cation channel complex [GO:0034703]; plasma membrane [GO:0005886]	GO:0005886; GO:0007338; GO:0015279; GO:0034703; GO:0051480; GO:0070588; GO:0070679
GN004952	GN004952.1	Q9JMI9	29.9	284	400	909	1.53e-36	145	TRPC3_RAT	Short transient receptor potential channel 3 (TrpC3) (Trp-related protein 3)	Rattus norvegicus (Rat)	calcium ion transmembrane transport [GO:0070588]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; single fertilization [GO:0007338]	calcium channel activity [GO:0005262]; calcium-activated cation channel activity [GO:0005227]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]	cation channel complex [GO:0034703]; plasma membrane [GO:0005886]	GO:0005227; GO:0005262; GO:0005886; GO:0007338; GO:0010524; GO:0015279; GO:0033198; GO:0034703; GO:0051480; GO:0051592; GO:0070588; GO:0070679; GO:1903244
GN004953	GN004953.1	Q9BXJ5	29.4	136	389	285	4.96e-09	60.5	C1QT2_HUMAN	Complement C1q tumor necrosis factor-related protein 2	Homo sapiens (Human)	regulation of lipid metabolic process [GO:0019216]	identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; protein-containing complex [GO:0032991]	GO:0005102; GO:0005576; GO:0019216; GO:0032991; GO:0042802
GN004954	GN004954.1	Q8TF42	41.5	265	306	649	9.77e-66	220	UBS3B_HUMAN	Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)	Homo sapiens (Human)	collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; negative regulation of bone resorption [GO:0045779]; negative regulation of signal transduction [GO:0009968]; platelet aggregation [GO:0070527]; regulation of osteoclast differentiation [GO:0045670]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]	identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; protein tyrosine phosphatase activity [GO:0004725]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004725; GO:0005634; GO:0005737; GO:0009968; GO:0031625; GO:0038063; GO:0042802; GO:0045670; GO:0045779; GO:0051219; GO:0051279; GO:0070527
GN004955	GN004955.1	Q6IDD9	55.7	628	904	1360	8.30e-221	666	SARM1_DROME	NAD(+) hydrolase sarm1 (NADase sarm1) (EC 3.2.2.6) (Sterile alpha and TIR motif-containing protein 1) (Tir-1 homolog)	Drosophila melanogaster (Fruit fly)	antiviral innate immune response [GO:0140374]; defense response to virus [GO:0051607]; NAD+ catabolic process [GO:0019677]; positive regulation of receptor signaling pathway via STAT [GO:1904894]; response to axon injury [GO:0048678]; signal transduction [GO:0007165]	NAD+ nucleosidase activity [GO:0003953]; NAD+ nucleosidase activity, cyclic ADP-ribose generating [GO:0061809]; signaling adaptor activity [GO:0035591]; STAT family protein binding [GO:0097677]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]	GO:0003953; GO:0005737; GO:0005739; GO:0005829; GO:0007165; GO:0019677; GO:0030424; GO:0030425; GO:0035591; GO:0043005; GO:0043025; GO:0048678; GO:0051607; GO:0061809; GO:0097677; GO:0140374; GO:1904894
GN004957	GN004957.1	Q99623	79.0	138	159	299	6.68e-65	203	PHB2_HUMAN	Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; B cell activation [GO:0042113]; cell migration [GO:0016477]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; regulation of cardiolipin metabolic process [GO:1900208]; regulation of transcription by RNA polymerase II [GO:0006357]; RIG-I signaling pathway [GO:0039529]; sister chromatid cohesion [GO:0007062]	binding [GO:0005488]; identical protein binding [GO:0042802]; nuclear estrogen receptor binding [GO:0030331]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; sphingolipid binding [GO:0046625]	cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial prohibitin complex [GO:0035632]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GO:0000423; GO:0002639; GO:0005488; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005886; GO:0006357; GO:0006606; GO:0007005; GO:0007062; GO:0009986; GO:0016363; GO:0016477; GO:0030331; GO:0032991; GO:0035632; GO:0039529; GO:0042113; GO:0042802; GO:0042803; GO:0043066; GO:0045892; GO:0046625; GO:0046982; GO:0050821; GO:0070374; GO:0071944; GO:0140374; GO:1900208; GO:1901224
GN004958	GN004958.1	P50093	53.7	54	68	294	4.16e-12	62.0	PHB2_CAEEL	Mitochondrial prohibitin complex protein 2 (Prohibitin-2)	Caenorhabditis elegans	defecation [GO:0030421]; embryo development ending in birth or egg hatching [GO:0009792]; gonad development [GO:0008406]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; oogenesis [GO:0048477]; positive regulation of multicellular organism growth [GO:0040018]; protein stabilization [GO:0050821]; regulation of nematode pharyngeal pumping [GO:0043051]; regulation of oxidative phosphorylation [GO:0002082]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283]	protein homodimerization activity [GO:0042803]	cell surface [GO:0009986]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial prohibitin complex [GO:0035632]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0000423; GO:0002082; GO:0005739; GO:0005743; GO:0005886; GO:0006979; GO:0007005; GO:0007283; GO:0008406; GO:0009792; GO:0009986; GO:0030421; GO:0031966; GO:0035632; GO:0040018; GO:0042803; GO:0043051; GO:0048477; GO:0050821
GN004961	GN004961.1	Q6ZMV7	38.5	122	700	132	1.84e-11	65.5	LEKR1_HUMAN	Protein LEKR1	Homo sapiens (Human)				
GN004962	GN004962.1	Q6TLE6	54.3	129	129	222	3.91e-41	139	CRCM1_DANRE	Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A)	Danio rerio (Zebrafish) (Brachydanio rerio)	positive regulation of calcium ion transport [GO:0051928]; sarcomere organization [GO:0045214]; store-operated calcium entry [GO:0002115]	store-operated calcium channel activity [GO:0015279]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0002115; GO:0005886; GO:0015279; GO:0016020; GO:0045214; GO:0051928
GN004968	GN004968.1	A0JMH0	57.7	104	110	371	5.25e-42	144	ASPH2_DANRE	Aspartate beta-hydroxylase domain-containing protein 2 (EC 1.14.11.-)	Danio rerio (Zebrafish) (Brachydanio rerio)			membrane [GO:0016020]	GO:0016020
GN004970	GN004970.1	Q6ZNF0	54.7	139	148	438	4.67e-44	152	ACP7_HUMAN	Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form)	Homo sapiens (Human)		acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872]	extracellular region [GO:0005576]	GO:0003993; GO:0005576; GO:0046872
GN004972	GN004972.1	Q19AE6	32.3	294	411	627	2.51e-42	160	ACHA4_MUSPF	Neuronal acetylcholine receptor subunit alpha-4	Mustela putorius furo (European domestic ferret) (Mustela furo)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; cognition [GO:0050890]; DNA repair [GO:0006281]; nervous system process [GO:0050877]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]	GO:0001666; GO:0005886; GO:0005892; GO:0006281; GO:0006979; GO:0007165; GO:0007271; GO:0015464; GO:0022848; GO:0035095; GO:0042734; GO:0045211; GO:0050877; GO:0050890; GO:0095500; GO:0097060
GN004973	GN004973.1	A9BJC1	29.3	460	611	503	8.99e-39	152	MGGB_PETMO	Mannosylglucosyl-3-phosphoglycerate phosphatase (MGPG phosphatase) (EC 3.1.3.-)	Petrotoga mobilis (strain DSM 10674 / SJ95)	nucleotide catabolic process [GO:0009166]	5'-nucleotidase activity [GO:0008253]; UDP-sugar diphosphatase activity [GO:0008768]	outer membrane-bounded periplasmic space [GO:0030288]	GO:0008253; GO:0008768; GO:0009166; GO:0030288
GN004974	GN004974.1	P41123	63.6	66	67	211	1.99e-17	75.1	RL13_RAT	Large ribosomal subunit protein eL13 (60S ribosomal protein L13)	Rattus norvegicus (Rat)	bone development [GO:0060348]; cytoplasmic translation [GO:0002181]; liver regeneration [GO:0097421]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; synapse [GO:0045202]	GO:0002181; GO:0003735; GO:0005730; GO:0005737; GO:0005783; GO:0005829; GO:0006412; GO:0022625; GO:0022626; GO:0045202; GO:0060348; GO:0097421
GN004975	GN004975.1	A0JPN4	47.9	219	901	596	3.07e-58	213	ZC12A_RAT	Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A)	Rattus norvegicus (Rat)	3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to chemokine [GO:1990869]; cellular response to glucose starvation [GO:0042149]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; cellular response to sodium arsenite [GO:1903936]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; DNA damage response [GO:0006974]; host-mediated suppression of viral genome replication [GO:0044828]; immune response-activating signaling pathway [GO:0002757]; miRNA catabolic process [GO:0010587]; mRNA catabolic process [GO:0006402]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of gene expression [GO:0010629]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of macrophage activation [GO:0043031]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein complex oligomerization [GO:0051259]; protein deubiquitination [GO:0016579]; regulation of gene expression [GO:0010468]; T cell receptor signaling pathway [GO:0050852]	chromatin binding [GO:0003682]; cysteine-type deubiquitinase activity [GO:0004843]; DNA binding [GO:0003677]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; nuclease activity [GO:0004518]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; RNA exonuclease activity [GO:0004532]; RNA nuclease activity [GO:0004540]; RNA stem-loop binding [GO:0035613]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; rough endoplasmic reticulum [GO:0005791]; rough endoplasmic reticulum membrane [GO:0030867]	GO:0000122; GO:0000932; GO:0001933; GO:0002230; GO:0002757; GO:0003677; GO:0003682; GO:0003723; GO:0003729; GO:0003730; GO:0004518; GO:0004521; GO:0004532; GO:0004540; GO:0004843; GO:0005634; GO:0005654; GO:0005737; GO:0005791; GO:0005856; GO:0006402; GO:0006974; GO:0008270; GO:0010468; GO:0010508; GO:0010587; GO:0010595; GO:0010628; GO:0010629; GO:0010656; GO:0010884; GO:0016579; GO:0030867; GO:0032689; GO:0032691; GO:0032715; GO:0032720; GO:0032991; GO:0034599; GO:0035198; GO:0035613; GO:0035925; GO:0036464; GO:0042149; GO:0042307; GO:0043022; GO:0043031; GO:0043124; GO:0044828; GO:0045019; GO:0045600; GO:0045766; GO:0045944; GO:0050852; GO:0051259; GO:0055118; GO:0061014; GO:0061158; GO:0071222; GO:0071356; GO:0098586; GO:1900016; GO:1900119; GO:1900745; GO:1901223; GO:1903003; GO:1903936; GO:1904637; GO:1990869; GO:2000320; GO:2000379; GO:2000627
GN004976	GN004976.1	Q8BJ64	65.2	563	816	596	6.29e-270	762	CHDH_MOUSE	Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)	Mus musculus (Mouse)	glycine betaine biosynthetic process from choline [GO:0019285]	choline dehydrogenase activity [GO:0008812]; flavin adenine dinucleotide binding [GO:0050660]	mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0005739; GO:0005741; GO:0005743; GO:0008812; GO:0019285; GO:0050660
GN004977	GN004977.1	Q8XIY6	34.0	97	284	214	2.77e-11	65.1	PPAX_CLOPE	Putative pyrophosphatase PpaX (EC 3.6.1.1)	Clostridium perfringens (strain 13 / Type A)	DNA repair [GO:0006281]	inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]; phosphoglycolate phosphatase activity [GO:0008967]	cytosol [GO:0005829]	GO:0000287; GO:0004427; GO:0005829; GO:0006281; GO:0008967
GN004978	GN004978.1	P97608	63.7	1313	1315	1288	0.0	1654	OPLA_RAT	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase)	Rattus norvegicus (Rat)		5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; identical protein binding [GO:0042802]	cytosol [GO:0005829]	GO:0005829; GO:0017168; GO:0042802
GN004979	GN004979.1	P54269	62.7	201	466	693	3.37e-65	225	CAUP_DROME	Homeobox protein caupolican	Drosophila melanogaster (Fruit fly)	cell development [GO:0048468]; compound eye morphogenesis [GO:0001745]; equator specification [GO:0045317]; imaginal disc-derived wing vein specification [GO:0007474]; muscle cell fate commitment [GO:0042693]; negative regulation of growth [GO:0045926]; neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001745; GO:0003700; GO:0005634; GO:0006357; GO:0007346; GO:0007474; GO:0030182; GO:0042693; GO:0045317; GO:0045926; GO:0045944; GO:0048468
GN004982	GN004982.1	P86952	36.9	407	710	456	1.39e-60	213	TYRO_PINMA	Tyrosinase-like protein (Tyrosinase-2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN004983	GN004983.1	O43313	40.9	115	728	823	7.82e-16	85.5	ATMIN_HUMAN	ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ) (Zinc finger protein 822)	Homo sapiens (Human)	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; dynein complex binding [GO:0070840]; transcription cis-regulatory region binding [GO:0000976]	nuclear body [GO:0016604]; nucleus [GO:0005634]	GO:0000976; GO:0000981; GO:0001228; GO:0005634; GO:0006357; GO:0016604; GO:0045893; GO:0045944; GO:0070840
GN004984	GN004984.1	Q68ED3	63.8	318	384	633	1.10e-127	384	PAPD5_MOUSE	Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2)	Mus musculus (Mouse)	carbohydrate homeostasis [GO:0033500]; histone mRNA catabolic process [GO:0071044]; miRNA catabolic process [GO:0010587]; mRNA 3'-end processing [GO:0031124]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; negative regulation of telomere maintenance via telomerase [GO:0032211]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; polyadenylation-dependent ncRNA catabolic process [GO:0043634]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; RNA 3'-end processing [GO:0031123]	guanylyltransferase activity [GO:0070568]; poly(A) RNA polymerase activity [GO:1990817]; telomerase RNA binding [GO:0070034]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; TRAMP complex [GO:0031499]	GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0010587; GO:0031123; GO:0031124; GO:0031499; GO:0032211; GO:0033500; GO:0043634; GO:0060212; GO:0070034; GO:0070568; GO:0071044; GO:0071051; GO:1905870; GO:1990817
GN004986	GN004986.1	Q8TB40	52.5	324	352	342	1.12e-110	329	ABHD4_HUMAN	(Lyso)-N-acylphosphatidylethanolamine lipase (EC 3.1.1.-) (Alpha/beta hydrolase domain-containing protein 4) (Abhydrolase domain-containing protein 4) (Alpha/beta-hydrolase 4)	Homo sapiens (Human)	N-acylphosphatidylethanolamine metabolic process [GO:0070292]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]	hydrolase activity [GO:0016787]; phosphatidylcholine lysophospholipase A1 activity [GO:0004622]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]	GO:0004622; GO:0005789; GO:0005811; GO:0006654; GO:0016787; GO:0036152; GO:0070292
GN004987	GN004987.1	P24367	55.1	187	224	207	3.43e-62	196	PPIB_CHICK	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	Gallus gallus (Chicken)	negative regulation of collagen fibril organization [GO:1904027]; protein folding [GO:0006457]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]; protein-containing complex [GO:0032991]	GO:0003755; GO:0005788; GO:0006457; GO:0016018; GO:0032991; GO:0042470; GO:1904027
GN004988	GN004988.1	P24369	69.7	109	122	216	5.25e-51	163	PPIB_MOUSE	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	Mus musculus (Mouse)	bone development [GO:0060348]; host-mediated activation of viral genome replication [GO:0044829]; host-mediated activation of viral process [GO:0044794]; neutrophil chemotaxis [GO:0030593]; positive regulation of multicellular organism growth [GO:0040018]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase binding [GO:0070063]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; smooth endoplasmic reticulum [GO:0005790]	GO:0003755; GO:0005654; GO:0005783; GO:0005788; GO:0005790; GO:0006457; GO:0016018; GO:0030593; GO:0032991; GO:0034663; GO:0040018; GO:0042470; GO:0044794; GO:0044829; GO:0048471; GO:0050821; GO:0060348; GO:0070063
GN004989	GN004989.1	Q8C190	33.6	125	366	649	3.51e-13	74.3	VP9D1_MOUSE	VPS9 domain-containing protein 1 (5-day ovary-specific transcript 1 protein)	Mus musculus (Mouse)	vesicle-mediated transport [GO:0016192]	guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; endocytic vesicle [GO:0030139]	GO:0005085; GO:0005829; GO:0016192; GO:0030139; GO:0031267; GO:0042802
GN004994	GN004994.1	G3V9R8	60.0	80	310	298	4.97e-25	105	HNRPC_RAT	Heterogeneous nuclear ribonucleoprotein C (hnRNP C) (hnRNP core protein C)	Rattus norvegicus (Rat)	3'-UTR-mediated mRNA stabilization [GO:0070935]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA modification [GO:0090367]; negative regulation of telomere maintenance via telomerase [GO:0032211]	deaminase binding [GO:1990827]; enzyme inhibitor activity [GO:0004857]; identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; poly(U) RNA binding [GO:0008266]; protein domain specific binding [GO:0019904]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	actin cytoskeleton [GO:0015629]; catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleoplasmic periphery of the nuclear pore complex [GO:1990826]; nucleus [GO:0005634]; pronucleus [GO:0045120]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]; telomerase holoenzyme complex [GO:0005697]	GO:0000398; GO:0003723; GO:0003729; GO:0003730; GO:0004857; GO:0005634; GO:0005654; GO:0005681; GO:0005697; GO:0005829; GO:0008266; GO:0015629; GO:0019904; GO:0032211; GO:0032991; GO:0042802; GO:0043021; GO:0045120; GO:0070034; GO:0070935; GO:0071013; GO:0090367; GO:1990247; GO:1990826; GO:1990827
GN004997	GN004997.1	Q96RK4	63.9	227	333	519	5.81e-96	296	BBS4_HUMAN	BBSome complex member BBS4 (Bardet-Biedl syndrome 4 protein)	Homo sapiens (Human)	adult behavior [GO:0030534]; brain morphogenesis [GO:0048854]; centrosome cycle [GO:0007098]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; dendrite development [GO:0016358]; fat cell differentiation [GO:0045444]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; maintenance of protein location in nucleus [GO:0051457]; melanosome transport [GO:0032402]; microtubule anchoring at centrosome [GO:0034454]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; positive regulation of cilium assembly [GO:0045724]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of cytokinesis [GO:0032465]; regulation of lipid metabolic process [GO:0019216]; retina homeostasis [GO:0001895]; retinal rod cell development [GO:0046548]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893]; spermatid development [GO:0007286]; striatum development [GO:0021756]	alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; dynactin binding [GO:0034452]; protein-macromolecule adaptor activity [GO:0030674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]	GO:0000226; GO:0000242; GO:0000281; GO:0001750; GO:0001843; GO:0001895; GO:0001917; GO:0001947; GO:0005634; GO:0005813; GO:0005814; GO:0005829; GO:0005929; GO:0007098; GO:0007286; GO:0007608; GO:0016358; GO:0019216; GO:0021756; GO:0021766; GO:0021987; GO:0030534; GO:0030674; GO:0031514; GO:0032391; GO:0032402; GO:0032465; GO:0034451; GO:0034452; GO:0034454; GO:0034464; GO:0035869; GO:0036064; GO:0038108; GO:0043014; GO:0045444; GO:0045494; GO:0045724; GO:0046548; GO:0048487; GO:0048854; GO:0050893; GO:0051457; GO:0060170; GO:0060271; GO:0060296; GO:0061512; GO:0061629; GO:0071539; GO:0097730; GO:1905515
GN004998	GN004998.1	Q9Y236	44.1	481	484	505	5.37e-131	392	OSGI2_HUMAN	Oxidative stress-induced growth inhibitor 2 (hT41)	Homo sapiens (Human)	negative regulation of cell growth [GO:0030308]	growth factor activity [GO:0008083]	midbody [GO:0030496]	GO:0008083; GO:0030308; GO:0030496
GN005000	GN005000.1	Q8SW43	29.1	172	815	190	5.09e-12	68.9	Z379_ENCCU	Zinc finger C2H2 protein ECU03_0790	Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)		DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634
GN005004	GN005004.1	Q9MYX0	48.8	250	318	630	3.95e-85	271	SC6A4_MACMU	Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4)	Macaca mulatta (Rhesus macaque)	amino acid transport [GO:0006865]; brain morphogenesis [GO:0048854]; enteric nervous system development [GO:0048484]; membrane depolarization [GO:0051899]; negative regulation of organ growth [GO:0046621]; platelet aggregation [GO:0070527]; positive regulation of cell cycle [GO:0045787]; positive regulation of gene expression [GO:0010628]; regulation of thalamus size [GO:0090067]; response to toxic substance [GO:0009636]; serotonin uptake [GO:0051610]; sodium ion transmembrane transport [GO:0035725]	actin filament binding [GO:0051015]; antiporter activity [GO:0015297]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; monoatomic cation channel activity [GO:0005261]; neurotransmitter transmembrane transporter activity [GO:0005326]; nitric-oxide synthase binding [GO:0050998]; serotonin binding [GO:0051378]; serotonin:sodium:chloride symporter activity [GO:0005335]; sodium ion binding [GO:0031402]	endomembrane system [GO:0012505]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synapse [GO:0045202]	GO:0005178; GO:0005261; GO:0005326; GO:0005335; GO:0005794; GO:0005886; GO:0005925; GO:0006865; GO:0009636; GO:0010008; GO:0010628; GO:0012505; GO:0015297; GO:0031402; GO:0035725; GO:0042802; GO:0043005; GO:0045121; GO:0045202; GO:0045787; GO:0046621; GO:0048484; GO:0048854; GO:0050998; GO:0051015; GO:0051378; GO:0051610; GO:0051899; GO:0070527; GO:0090067; GO:0098793
GN005005	GN005005.1	P27922	59.5	126	149	693	2.63e-43	154	SC6A3_BOVIN	Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3)	Bos taurus (Bovine)	amino acid transport [GO:0006865]; hyaloid vascular plexus regression [GO:1990384]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725]	dopamine:sodium symporter activity [GO:0005330]	axon [GO:0030424]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	GO:0005330; GO:0005886; GO:0006836; GO:0006865; GO:0030424; GO:0035725; GO:0043005; GO:1990384
GN005007	GN005007.1	O88576	46.0	585	697	615	2.79e-183	537	S6A18_MOUSE	Sodium-dependent neutral amino acid transporter B(0)AT3 (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3)	Mus musculus (Mouse)	amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; neutral amino acid transport [GO:0015804]; renal amino acid absorption [GO:1990297]; sodium ion transmembrane transport [GO:0035725]	neutral L-amino acid transmembrane transporter activity [GO:0015175]; neutral L-amino acid:sodium:chloride symporter activity [GO:0140931]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]	GO:0003333; GO:0005886; GO:0006865; GO:0015175; GO:0015804; GO:0016324; GO:0031526; GO:0035725; GO:0140931; GO:1990297
GN005010	GN005010.1	A2AX52	31.3	393	402	2309	5.52e-46	173	CO6A4_MOUSE	Collagen alpha-4(VI) chain	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]	collagen binding [GO:0005518]	collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991]	GO:0005518; GO:0005576; GO:0005589; GO:0030198; GO:0031012; GO:0032991
GN005012	GN005012.1	Q04164	28.1	310	1393	1693	1.06e-19	100	SAS_DROME	Putative epidermal cell surface receptor (Stranded at second protein)	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell signaling via exosome [GO:0099156]; instar larval development [GO:0002168]; positive regulation of cell differentiation [GO:0045597]	integrin binding [GO:0005178]; membrane-membrane adaptor activity [GO:0140177]; molecular adaptor activity [GO:0060090]; signaling receptor activity [GO:0038023]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	GO:0002168; GO:0005178; GO:0005886; GO:0007155; GO:0007411; GO:0016324; GO:0038023; GO:0045597; GO:0060090; GO:0070062; GO:0099156; GO:0140177
GN005015	GN005015.1	Q32KJ6	65.6	189	194	524	1.31e-83	259	GALNS_RAT	N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase)	Rattus norvegicus (Rat)	chondroitin sulfate proteoglycan catabolic process [GO:0030207]	arylsulfatase activity [GO:0004065]; N-acetylgalactosamine-6-sulfatase activity [GO:0043890]; sulfuric ester hydrolase activity [GO:0008484]	lysosome [GO:0005764]	GO:0004065; GO:0005764; GO:0008484; GO:0030207; GO:0043890
GN005016	GN005016.1	Q9BYN7	40.9	618	931	854	1.14e-98	332	ZN341_HUMAN	Zinc finger protein 341	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001216; GO:0003677; GO:0005634; GO:0006355
GN005019	GN005019.1	Q52556	34.4	532	523	528	3.25e-86	278	LPAKS_PSES9	Linear primary-alkylsulfatase (EC 3.1.6.21) (SDSase) (Type III linear primary-alkylsulfatase)	Pseudomonas sp. (strain ATCC 19151)	dodecyl sulfate metabolic process [GO:0018909]	linear primary-alkylsulfatase activity [GO:0018741]; protein dimerization activity [GO:0046983]		GO:0018741; GO:0018909; GO:0046983
GN005023	GN005023.1	O73853	34.4	471	501	514	6.53e-86	276	CP17A_ICTPU	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)	Ictalurus punctatus (Channel catfish) (Silurus punctatus)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid biosynthetic process [GO:0006694]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	membrane [GO:0016020]	GO:0004508; GO:0005506; GO:0006694; GO:0016020; GO:0020037; GO:0042446; GO:0042448
GN005025	GN005025.1	P30684	83.3	378	378	376	9.63e-234	643	GNAS_LYMST	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; sensory perception of chemical stimulus [GO:0007606]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; heterotrimeric G-protein complex [GO:0005834]	GO:0001664; GO:0003924; GO:0005525; GO:0005737; GO:0005834; GO:0007191; GO:0007606; GO:0031683
GN005026	GN005026.1	P30664	69.8	841	897	863	0.0	1144	MCM4B_XENLA	DNA replication licensing factor mcm4-B (EC 3.6.4.12) (CDC21 homolog-B) (Minichromosome maintenance protein 4-B) (xMCM4-B) (P1-CDC21-B)	Xenopus laevis (African clawed frog)	cell cycle DNA replication [GO:0044786]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; premeiotic DNA replication [GO:0006279]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]	chromatin [GO:0000785]; chromosome [GO:0005694]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; nucleus [GO:0005634]	GO:0000727; GO:0000785; GO:0003682; GO:0003697; GO:0005524; GO:0005634; GO:0005694; GO:0006271; GO:0006279; GO:0016887; GO:0017116; GO:0030174; GO:0042555; GO:0044786; GO:0071162; GO:1902975
GN005027	GN005027.1	Q8R3F5	45.2	314	359	381	7.66e-85	265	FABD_MOUSE	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase)	Mus musculus (Mouse)	fatty acid biosynthetic process [GO:0006633]; mitochondrial small ribosomal subunit assembly [GO:0180026]	[acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; RNA folding chaperone [GO:0140691]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004314; GO:0005739; GO:0005759; GO:0006633; GO:0140691; GO:0180026
GN005028	GN005028.1	Q4V8B3	32.0	1016	1014	987	1.98e-154	486	MED24_RAT	Mediator of RNA polymerase II transcription subunit 24 (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4)	Rattus norvegicus (Rat)	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein ubiquitination [GO:0016567]; stem cell population maintenance [GO:0019827]; transcription by RNA polymerase II [GO:0006366]	histone acetyltransferase activity [GO:0004402]; nuclear thyroid hormone receptor binding [GO:0046966]; protein-containing complex binding [GO:0044877]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	mediator complex [GO:0016592]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0003712; GO:0003713; GO:0004402; GO:0005634; GO:0006366; GO:0016567; GO:0016592; GO:0019827; GO:0044877; GO:0045893; GO:0046966; GO:0060261
GN005029	GN005029.1	B3EWY6	29.6	142	237	386	3.91e-15	77.0	SAAR1_ACRMI	Skeletal aspartic acid-rich protein 1	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]	GO:0005576
GN005030	GN005030.1	Q9BWW7	63.1	84	435	348	7.74e-27	113	SCRT1_HUMAN	Transcriptional repressor scratch 1 (Scratch homolog 1 zinc finger protein) (SCRT) (Scratch 1) (hScrt)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	nuclear body [GO:0016604]; nucleus [GO:0005634]	GO:0000122; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0003700; GO:0005634; GO:0006355; GO:0016604; GO:0043565; GO:1990837
GN005038	GN005038.1	Q9W345	71.3	150	480	934	9.10e-68	236	ZDHC8_DROME	Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (Zinc finger DHHC-type containing 8)	Drosophila melanogaster (Fruit fly)		palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	GO:0000139; GO:0005886; GO:0016409; GO:0019706
GN005040	GN005040.1	Q9R1S4	50.4	137	412	267	7.75e-21	94.7	XBP1_RAT	X-box-binding protein 1 (Hepatocarcinogenesis-related transcription factor) (HTF) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]	Rattus norvegicus (Rat)	adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; cellular response to amino acid stimulus [GO:0071230]; cellular response to antibiotic [GO:0071236]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cholesterol homeostasis [GO:0042632]; endoplasmic reticulum unfolded protein response [GO:0030968]; endothelial cell proliferation [GO:0001935]; epithelial cell maturation [GO:0002070]; epithelial cell maturation involved in salivary gland development [GO:0060691]; exocrine pancreas development [GO:0031017]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; intracellular triglyceride homeostasis [GO:0035356]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; liver development [GO:0001889]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron development [GO:0048666]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular wound healing [GO:0035470]; protein destabilization [GO:0031648]; regulation of autophagy [GO:0010506]; regulation of cell growth [GO:0001558]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein stability [GO:0031647]; regulation of transcription by RNA polymerase II [GO:0006357]; response to electrical stimulus [GO:0051602]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; serotonin secretion, neurotransmission [GO:0060096]; sterol homeostasis [GO:0055092]; transcription by RNA polymerase II [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	chromatin DNA binding [GO:0031490]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleus [GO:0005634]; presynapse [GO:0098793]	GO:0000122; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0000987; GO:0001228; GO:0001525; GO:0001558; GO:0001889; GO:0001934; GO:0001935; GO:0002020; GO:0002070; GO:0002639; GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0005783; GO:0005789; GO:0005829; GO:0006355; GO:0006357; GO:0006366; GO:0006511; GO:0007584; GO:0008284; GO:0009410; GO:0010506; GO:0010508; GO:0010832; GO:0016020; GO:0019901; GO:0030335; GO:0030512; GO:0030968; GO:0031017; GO:0031490; GO:0031625; GO:0031647; GO:0031648; GO:0031670; GO:0032008; GO:0032755; GO:0032869; GO:0034599; GO:0034976; GO:0035356; GO:0035470; GO:0035924; GO:0036312; GO:0036498; GO:0042149; GO:0042307; GO:0042593; GO:0042632; GO:0042802; GO:0042826; GO:0043066; GO:0043491; GO:0043565; GO:0044389; GO:0045348; GO:0045579; GO:0045582; GO:0045600; GO:0045766; GO:0045944; GO:0046982; GO:0048010; GO:0048666; GO:0051602; GO:0051897; GO:0055089; GO:0055092; GO:0060096; GO:0060392; GO:0060612; GO:0060691; GO:0061629; GO:0070059; GO:0070373; GO:0071222; GO:0071230; GO:0071236; GO:0071332; GO:0071333; GO:0071353; GO:0071375; GO:0071498; GO:0071499; GO:0098793; GO:1900017; GO:1900100; GO:1900102; GO:1901800; GO:1901985; GO:1902236; GO:1903489; GO:1904707; GO:1904754; GO:1990418; GO:1990830; GO:1990837; GO:2000347; GO:2000353
GN005041	GN005041.1	Q2KIY5	54.6	469	472	589	3.81e-175	507	PLBL2_BOVIN	Putative aminopeptidase PLBD2 (EC 3.4.11.-) (LAMA-like protein 2) (Lamina ancestor homolog 2) (Phospholipase B domain-containing protein 2) [Cleaved into: Putative aminopeptidase PLBD2 chain A; Putative aminopeptidase PLBD2 chain B]	Bos taurus (Bovine)		glycerophospholipase activity [GO:0004620]	extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]	GO:0004620; GO:0005576; GO:0043202
GN005042	GN005042.1	D3ZL52	39.9	233	244	234	8.08e-42	145	SESQ1_RAT	Sesquipedalian-1 (Ses1) (27 kDa inositol polyphosphate phosphatase interacting protein A) (IPIP27A) (PH domain-containing endocytic trafficking adaptor 1)	Rattus norvegicus (Rat)	endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]	protein homodimerization activity [GO:0042803]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]	GO:0001881; GO:0005769; GO:0005802; GO:0005829; GO:0007032; GO:0030136; GO:0042147; GO:0042803; GO:0055037
GN005043	GN005043.1	Q8C8H8	26.7	404	1150	661	1.46e-27	123	KY_MOUSE	Kyphoscoliosis peptidase (EC 3.4.-.-)	Mus musculus (Mouse)	muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]	GO:0005737; GO:0005856; GO:0007517; GO:0007528; GO:0030018
GN005044	GN005044.1	P42346	65.1	2540	2478	2549	0.0	3197	MTOR_RAT	Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin target protein 1) (RAPT1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2)	Rattus norvegicus (Rat)	'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; behavioral response to pain [GO:0048266]; cardiac cell development [GO:0055006]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle tissue development [GO:0048738]; cell projection organization [GO:0030030]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to L-leucine [GO:0071233]; cellular response to leucine starvation [GO:1990253]; cellular response to methionine [GO:0061431]; cellular response to nutrient [GO:0031670]; cellular response to nutrient levels [GO:0031669]; cellular response to starvation [GO:0009267]; energy reserve metabolic process [GO:0006112]; germ cell development [GO:0007281]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; inflammatory response [GO:0006954]; long-term memory [GO:0007616]; maternal process involved in female pregnancy [GO:0060135]; mRNA stabilization [GO:0048255]; multicellular organism growth [GO:0035264]; negative regulation of autophagy [GO:0010507]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cell size [GO:0045792]; negative regulation of cholangiocyte apoptotic process [GO:1904193]; negative regulation of iodide transmembrane transport [GO:1904213]; negative regulation of lysosome organization [GO:1905672]; negative regulation of macroautophagy [GO:0016242]; negative regulation of muscle atrophy [GO:0014736]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; neuronal action potential [GO:0019228]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of cellular senescence [GO:2000774]; positive regulation of cholangiocyte proliferation [GO:1904056]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of eating behavior [GO:1904000]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of granulosa cell proliferation [GO:1904197]; positive regulation of keratinocyte migration [GO:0051549]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neuron maturation [GO:0014042]; positive regulation of neuron projection development [GO:0010976]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process [GO:0062027]; positive regulation of skeletal muscle hypertrophy [GO:1904206]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; post-embryonic development [GO:0009791]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of brown fat cell differentiation [GO:0090335]; regulation of carbohydrate metabolic process [GO:0006109]; regulation of carbohydrate utilization [GO:0043610]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; regulation of circadian rhythm [GO:0042752]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of locomotor rhythm [GO:1904059]; regulation of lysosome organization [GO:1905671]; regulation of membrane permeability [GO:0090559]; regulation of myelination [GO:0031641]; regulation of osteoclast differentiation [GO:0045670]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of protein kinase activity [GO:0045859]; regulation of protein phosphorylation [GO:0001932]; regulation of response to food [GO:0032095]; regulation of translation at synapse, modulating synaptic transmission [GO:0099547]; response to activity [GO:0014823]; response to amino acid [GO:0043200]; response to cocaine [GO:0042220]; response to heat [GO:0009408]; response to insulin [GO:0032868]; response to nutrient levels [GO:0031667]; response to virus [GO:0009615]; social behavior [GO:0035176]; spinal cord development [GO:0021510]; T-helper 1 cell lineage commitment [GO:0002296]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; TORC2 signaling [GO:0038203]; visual learning [GO:0008542]; voluntary musculoskeletal movement [GO:0050882]	identical protein binding [GO:0042802]; inositol hexakisphosphate binding [GO:0000822]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphoprotein binding [GO:0051219]; protein domain specific binding [GO:0019904]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; ribosome binding [GO:0043022]; RNA polymerase III type 1 promoter sequence-specific DNA binding [GO:0001002]; RNA polymerase III type 2 promoter sequence-specific DNA binding [GO:0001003]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TFIIIC-class transcription factor complex binding [GO:0001156]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic cytosol [GO:0099524]; protein-containing complex [GO:0032991]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]	GO:0000139; GO:0000822; GO:0001002; GO:0001003; GO:0001006; GO:0001156; GO:0001558; GO:0001932; GO:0001933; GO:0001934; GO:0001938; GO:0002296; GO:0003007; GO:0003179; GO:0004672; GO:0004674; GO:0004713; GO:0004715; GO:0005634; GO:0005635; GO:0005737; GO:0005741; GO:0005764; GO:0005765; GO:0005783; GO:0005789; GO:0005794; GO:0005829; GO:0005886; GO:0005979; GO:0006109; GO:0006112; GO:0006207; GO:0006468; GO:0006954; GO:0007281; GO:0007616; GO:0008361; GO:0008542; GO:0009267; GO:0009408; GO:0009615; GO:0009791; GO:0010506; GO:0010507; GO:0010592; GO:0010718; GO:0010831; GO:0010976; GO:0012505; GO:0014042; GO:0014736; GO:0014823; GO:0016020; GO:0016242; GO:0016605; GO:0018105; GO:0018107; GO:0019228; GO:0019901; GO:0019904; GO:0021510; GO:0030030; GO:0030425; GO:0030838; GO:0031397; GO:0031641; GO:0031667; GO:0031669; GO:0031670; GO:0031929; GO:0031931; GO:0031932; GO:0031998; GO:0032095; GO:0032868; GO:0032869; GO:0032956; GO:0032991; GO:0034198; GO:0035176; GO:0035264; GO:0038202; GO:0038203; GO:0042220; GO:0042752; GO:0042802; GO:0043022; GO:0043025; GO:0043200; GO:0043491; GO:0043525; GO:0043610; GO:0044325; GO:0045335; GO:0045429; GO:0045670; GO:0045727; GO:0045792; GO:0045859; GO:0045860; GO:0045945; GO:0045948; GO:0046777; GO:0046889; GO:0048255; GO:0048266; GO:0048661; GO:0048714; GO:0048738; GO:0050731; GO:0050769; GO:0050882; GO:0051219; GO:0051496; GO:0051549; GO:0051896; GO:0051897; GO:0055006; GO:0055013; GO:0060048; GO:0060135; GO:0060252; GO:0060999; GO:0061051; GO:0061431; GO:0062027; GO:0070885; GO:0071230; GO:0071233; GO:0071456; GO:0090335; GO:0090559; GO:0098978; GO:0099524; GO:0099547; GO:0106310; GO:1900029; GO:1900181; GO:1901838; GO:1903691; GO:1904000; GO:1904037; GO:1904056; GO:1904059; GO:1904193; GO:1904197; GO:1904206; GO:1904213; GO:1905671; GO:1905672; GO:1990253; GO:2000060; GO:2000774; GO:2000785
GN005045	GN005045.1	Q99442	53.8	91	193	399	1.07e-24	102	SEC62_HUMAN	Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1)	Homo sapiens (Human)	cotranslational protein targeting to membrane [GO:0006613]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; post-translational protein targeting to membrane, translocation [GO:0031204]; reticulophagy [GO:0061709]	signaling receptor activity [GO:0038023]; transmembrane protein transporter activity [GO:0008320]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; rough endoplasmic reticulum [GO:0005791]	GO:0005783; GO:0005789; GO:0005791; GO:0006613; GO:0006620; GO:0008320; GO:0016020; GO:0031204; GO:0038023; GO:0061709
GN005047	GN005047.1	Q5RC70	39.6	278	295	559	3.11e-55	190	DJC11_PONAB	DnaJ homolog subfamily C member 11	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	cristae formation [GO:0042407]		MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]	GO:0005741; GO:0042407; GO:0140275
GN005048	GN005048.1	Q9NVH1	42.3	234	232	559	3.36e-51	177	DJC11_HUMAN	DnaJ homolog subfamily C member 11	Homo sapiens (Human)	cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]		MIB complex [GO:0140275]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0005739; GO:0005741; GO:0007007; GO:0042407; GO:0140275
GN005050	GN005050.1	P22758	35.6	725	828	836	8.85e-152	468	TGM1_RABIT	Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) [Cleaved into: Protein-glutamine gamma-glutamyltransferase K 67 kDa chain; Protein-glutamine gamma-glutamyltransferase K 33 kDa chain]	Oryctolagus cuniculus (Rabbit)	animal organ development [GO:0048513]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838]	protein-glutamine gamma-glutamyltransferase activity [GO:0003810]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0003810; GO:0005829; GO:0005886; GO:0010838; GO:0045787; GO:0048513
GN005052	GN005052.1	Q6INN8	52.8	555	627	632	2.82e-193	561	SAMH1_XENLA	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-)	Xenopus laevis (African clawed frog)	dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; deoxyribonucleotide catabolic process [GO:0009264]; dGTP catabolic process [GO:0006203]; DNA damage response [GO:0006974]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein homotetramerization [GO:0051289]; regulation of innate immune response [GO:0045088]; somatic hypermutation of immunoglobulin genes [GO:0016446]	deoxynucleoside triphosphate hydrolase activity [GO:0106375]; dGTP binding [GO:0032567]; dGTPase activity [GO:0008832]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; triphosphoric monoester hydrolase activity [GO:0016793]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000724; GO:0003676; GO:0003697; GO:0003723; GO:0005634; GO:0005694; GO:0006203; GO:0006974; GO:0008270; GO:0008832; GO:0009264; GO:0016446; GO:0016793; GO:0032567; GO:0035861; GO:0045088; GO:0046061; GO:0051289; GO:0051607; GO:0060339; GO:0106375; GO:0110025
GN005053	GN005053.1	Q9NS37	40.9	132	346	354	6.18e-16	81.3	ZHANG_HUMAN	CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei)	Homo sapiens (Human)	ATF6-mediated unfolded protein response [GO:0036500]; integrated stress response signaling [GO:0140467]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]	chromatin [GO:0000785]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000785; GO:0000981; GO:0003677; GO:0005634; GO:0006357; GO:0009615; GO:0036500; GO:0042802; GO:0045814; GO:0045892; GO:0045944; GO:0090575; GO:0140467
GN005057	GN005057.1	Q8C3S2	32.9	1211	1170	1079	6.71e-167	526	TNG6_MOUSE	Transport and Golgi organization protein 6 homolog (Transmembrane and coiled-coil domain-containing protein 7)	Mus musculus (Mouse)	protein secretion [GO:0009306]		membrane [GO:0016020]	GO:0009306; GO:0016020
GN005070	GN005070.1	Q7ZWG9	57.2	215	229	222	2.48e-91	270	SGMR1_DANRE	Sigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor) (Sigma1-receptor) (Sigma1R)	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of cellular respiration [GO:0043457]; regulation of neuron apoptotic process [GO:0043523]; regulation of response to endoplasmic reticulum stress [GO:1905897]; response to wounding [GO:0009611]; retinal rod cell development [GO:0046548]; swimming behavior [GO:0036269]	signaling receptor activity [GO:0038023]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; postsynaptic density [GO:0014069]	GO:0005635; GO:0005637; GO:0005640; GO:0005783; GO:0005789; GO:0009611; GO:0014069; GO:0016020; GO:0031410; GO:0036269; GO:0038023; GO:0043457; GO:0043523; GO:0046548; GO:1905897
GN005074	GN005074.1	Q5RDQ8	23.6	462	902	922	3.47e-22	106	GRM7_PONAB	Metabotropic glutamate receptor 7 (mGluR7)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; axon development [GO:0061564]	glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]; protein dimerization activity [GO:0046983]	plasma membrane [GO:0005886]	GO:0001642; GO:0005886; GO:0007196; GO:0008066; GO:0046983; GO:0061564
GN005075	GN005075.1	A7S8T5	69.0	300	312	312	4.54e-127	368	CCD42_NEMVE	Coiled-coil domain-containing protein 42 homolog	Nematostella vectensis (Starlet sea anemone)			cytoskeleton [GO:0005856]	GO:0005856
GN005076	GN005076.1	Q640K1	34.3	102	298	720	1.03e-09	62.8	NCDN_XENLA	Neurochondrin	Xenopus laevis (African clawed frog)	neuron projection development [GO:0031175]; regulation of neuronal synaptic plasticity [GO:0048168]		cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]	GO:0005829; GO:0030425; GO:0031175; GO:0043025; GO:0048168; GO:0098794
GN005077	GN005077.1	O13997	30.1	113	118	280	3.85e-09	55.8	YIH1_SCHPO	Protein IMPACT homolog	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	cellular response to amino acid starvation [GO:0034198]; GCN2-mediated signaling [GO:0140469]; regulation of cytoplasmic translational initiation in response to stress [GO:1990611]; regulation of translational initiation [GO:0006446]	protein sequestering activity [GO:0140311]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0006446; GO:0034198; GO:0140311; GO:0140469; GO:1990611
GN005078	GN005078.1	Q9P243	25.2	742	1277	1243	3.77e-59	227	ZFAT_HUMAN	Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406)	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0005829; GO:0006355
GN005083	GN005083.1	Q0P6D2	28.8	396	416	419	4.65e-42	156	DIK1C_HUMAN	Divergent protein kinase domain 1C (Protein FAM69C)	Homo sapiens (Human)		protein serine/threonine kinase activity [GO:0004674]	endoplasmic reticulum membrane [GO:0005789]	GO:0004674; GO:0005789
GN005084	GN005084.1	Q8BQT2	33.1	151	207	410	6.44e-19	87.0	DIK1C_MOUSE	Divergent protein kinase domain 1C (Protein FAM69C)	Mus musculus (Mouse)	brain development [GO:0007420]; dendritic spine development [GO:0060996]; gene expression [GO:0010467]; maintenance of synapse structure [GO:0099558]; memory [GO:0007613]; neuron apoptotic process [GO:0051402]; neuron development [GO:0048666]; regulation of synaptic plasticity [GO:0048167]; response to stress [GO:0006950]; synapse organization [GO:0050808]	protein serine/threonine kinase activity [GO:0004674]	endoplasmic reticulum membrane [GO:0005789]	GO:0004674; GO:0005789; GO:0006950; GO:0007420; GO:0007613; GO:0010467; GO:0048167; GO:0048666; GO:0050808; GO:0051402; GO:0060996; GO:0099558
GN005085	GN005085.1	Q2TB18	29.9	521	548	679	3.89e-72	246	ASTE1_HUMAN	Single-strand DNA endonuclease ASTE1 (EC 3.1.-.-) (Protein asteroid homolog 1)	Homo sapiens (Human)	double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]	3' overhang single-stranded DNA endonuclease activity [GO:1990599]; single-stranded DNA endonuclease activity [GO:0000014]		GO:0000014; GO:0000724; GO:0006303; GO:1990599
GN005088	GN005088.1	Q6B4Z5	29.5	146	1270	801	7.86e-11	70.5	ZFY_PANTR	Zinc finger Y-chromosomal protein	Pan troglodytes (Chimpanzee)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0006357; GO:0043565; GO:0046872
GN005091	GN005091.1	Q9CZW2	41.4	87	112	337	2.34e-15	73.2	CENPN_MOUSE	Centromere protein N (CENP-N)	Mus musculus (Mouse)	CENP-A containing chromatin assembly [GO:0034080]; chromosome segregation [GO:0007059]		inner kinetochore [GO:0000939]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000939; GO:0005634; GO:0005654; GO:0007059; GO:0034080
GN005093	GN005093.1	Q9W4P5	78.8	259	259	350	1.71e-150	426	VA0D1_DROME	V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (V-ATPase 39 kDa subunit) (Vacuolar H+ ATPase subunit AC39-1) (Vacuolar proton pump subunit d 1)	Drosophila melanogaster (Fruit fly)	cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; proton transmembrane transport [GO:1902600]; terminal branching, open tracheal system [GO:0007430]; vacuolar acidification [GO:0007035]; vacuolar transport [GO:0007034]	proton-transporting ATPase activity, rotational mechanism [GO:0046961]	early endosome [GO:0005769]; plasma membrane [GO:0005886]; plasma membrane proton-transporting V-type ATPase complex [GO:0033181]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	GO:0000220; GO:0005769; GO:0005886; GO:0006879; GO:0007034; GO:0007035; GO:0007430; GO:0016471; GO:0033181; GO:0036295; GO:0046961; GO:1902600
GN005100	GN005100.1	Q8BHT6	53.3	150	181	489	4.29e-47	163	B3GLT_MOUSE	Beta-1,3-glucosyltransferase (Beta3Glc-T) (EC 2.4.1.-) (Beta 3-glucosyltransferase) (Beta-3-glycosyltransferase-like)	Mus musculus (Mouse)	brain development [GO:0007420]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; cilium organization [GO:0044782]; cranial skeletal system development [GO:1904888]; gene expression [GO:0010467]; limb development [GO:0060173]; protein O-linked glycosylation via fucose [GO:0036066]; protein secretion [GO:0009306]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]	acetylglucosaminyltransferase activity [GO:0008375]; glycosyltransferase activity [GO:0016757]; O-fucosylpeptide 3-beta-glucosyltransferase activity [GO:0160265]	endoplasmic reticulum membrane [GO:0005789]	GO:0001501; GO:0005789; GO:0007420; GO:0008375; GO:0009306; GO:0010467; GO:0016757; GO:0036066; GO:0043010; GO:0044782; GO:0060021; GO:0060173; GO:0060271; GO:0160265; GO:1904888
GN005103	GN005103.1	A2VDX7	41.5	289	390	370	2.76e-69	225	EXO5_BOVIN	Exonuclease V (Exo V) (EC 3.1.-.-) (Defects in morphology protein 1 homolog)	Bos taurus (Bovine)	interstrand cross-link repair [GO:0036297]	4 iron, 4 sulfur cluster binding [GO:0051539]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0016607; GO:0036297; GO:0045145; GO:0051539
GN005107	GN005107.1	P51452	47.7	153	192	185	1.28e-43	146	DUS3_HUMAN	Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR)	Homo sapiens (Human)	cellular response to epidermal growth factor stimulus [GO:0071364]; dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of focal adhesion assembly [GO:0051893]	cytoskeletal protein binding [GO:0008092]; MAP kinase phosphatase activity [GO:0033549]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; receptor signaling protein tyrosine kinase inhibitor activity [GO:0030294]; receptor tyrosine kinase binding [GO:0030971]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001772; GO:0004722; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0008092; GO:0008138; GO:0016311; GO:0016791; GO:0019901; GO:0030294; GO:0030336; GO:0030971; GO:0033549; GO:0035335; GO:0042059; GO:0043409; GO:0045931; GO:0046329; GO:0050860; GO:0050868; GO:0050922; GO:0051893; GO:0070373; GO:0071364; GO:0120183; GO:1990782
GN005109	GN005109.1	Q08J23	48.1	675	764	767	1.15e-209	613	NSUN2_HUMAN	RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4)	Homo sapiens (Human)	hair follicle maturation [GO:0048820]; mRNA processing [GO:0006397]; regulation of mRNA export from nucleus [GO:0010793]; regulation of stem cell differentiation [GO:2000736]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]; tRNA stabilization [GO:0036416]	mRNA (cytidine-5-)-methyltransferase activity [GO:0062152]; RNA binding [GO:0003723]; tRNA (cytidine-N5)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0000049; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005739; GO:0005819; GO:0006397; GO:0006400; GO:0010793; GO:0016428; GO:0030488; GO:0036416; GO:0048820; GO:0062152; GO:0070062; GO:2000736
GN005110	GN005110.1	Q8TBB5	43.6	459	544	520	7.10e-132	397	KLDC4_HUMAN	Kelch domain-containing protein 4	Homo sapiens (Human)				
GN005111	GN005111.1	Q9UH36	38.5	265	282	339	1.54e-50	172	SRR1L_HUMAN	SRR1-like protein (SRR1 domain-containing protein)	Homo sapiens (Human)	regulation of circadian rhythm [GO:0042752]; regulation of heme biosynthetic process [GO:0070453]		cytoplasm [GO:0005737]	GO:0005737; GO:0042752; GO:0070453
GN005112	GN005112.1	Q498S6	27.1	376	922	1168	1.14e-13	79.3	ZCHC2_RAT	Zinc finger CCHC domain-containing protein 2	Rattus norvegicus (Rat)		nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0003676; GO:0005737; GO:0008270; GO:0035091
GN005113	GN005113.1	Q8BZZ3	63.1	122	225	918	2.14e-21	95.5	WWP1_MOUSE	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase WWP1) (WW domain-containing protein 1)	Mus musculus (Mouse)	lung development [GO:0030324]; negative regulation of DNA-templated transcription [GO:0045892]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; T cell differentiation [GO:0030217]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	anchoring junction [GO:0070161]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0016567; GO:0030217; GO:0030324; GO:0043161; GO:0045892; GO:0061630; GO:0070161
GN005114	GN005114.1	Q4R537	44.6	359	376	412	4.06e-69	226	NOB1_MACFA	RNA-binding protein NOB1 (EC 3.1.-.-)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	maturation of SSU-rRNA [GO:0030490]	RNA endonuclease activity [GO:0004521]	nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]	GO:0004521; GO:0005634; GO:0030490; GO:0030688
GN005117	GN005117.1	P20060	70.6	68	79	536	5.13e-28	107	HEXB_MOUSE	Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (N-acetyl-beta-glucosaminidase subunit beta)	Mus musculus (Mouse)	astrocyte cell migration [GO:0043615]; chondroitin sulfate proteoglycan catabolic process [GO:0030207]; dermatan sulfate proteoglycan catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan metabolic process [GO:0030203]; glycosphingolipid metabolic process [GO:0006687]; hyaluronan catabolic process [GO:0030214]; intracellular calcium ion homeostasis [GO:0006874]; lipid storage [GO:0019915]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; male courtship behavior [GO:0008049]; myelination [GO:0042552]; N-acetylglucosamine metabolic process [GO:0006044]; neuromuscular process [GO:0050905]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]; oogenesis [GO:0048477]; penetration of zona pellucida [GO:0007341]; phospholipid biosynthetic process [GO:0008654]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; single fertilization [GO:0007338]; skeletal system development [GO:0001501]	acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylglucosaminidase activity [GO:0016231]; beta-N-acetylhexosaminidase activity [GO:0004563]; carbohydrate binding [GO:0030246]; hexosaminidase activity [GO:0015929]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; azurophil granule [GO:0042582]; beta-N-acetylhexosaminidase complex [GO:1905379]; cortical granule [GO:0060473]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]	GO:0001501; GO:0001669; GO:0004563; GO:0005576; GO:0005764; GO:0006044; GO:0006687; GO:0006689; GO:0006874; GO:0007040; GO:0007338; GO:0007341; GO:0007605; GO:0007626; GO:0008049; GO:0008360; GO:0008375; GO:0008654; GO:0009313; GO:0015929; GO:0016020; GO:0016231; GO:0016787; GO:0019915; GO:0030203; GO:0030207; GO:0030209; GO:0030214; GO:0030246; GO:0042552; GO:0042582; GO:0042802; GO:0043202; GO:0043615; GO:0044877; GO:0045944; GO:0048477; GO:0050885; GO:0050905; GO:0060473; GO:1905379
GN005121	GN005121.1	Q5PQY6	64.5	848	849	840	0.0	1029	LONP2_DANRE	Lon protease homolog 2, peroxisomal (EC 3.4.21.53)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein import into peroxisome matrix [GO:0016558]; protein processing [GO:0016485]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein targeting to peroxisome [GO:0006625]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	peroxisomal matrix [GO:0005782]	GO:0004176; GO:0004252; GO:0005524; GO:0005782; GO:0006515; GO:0006625; GO:0008233; GO:0016485; GO:0016558; GO:0016887
GN005123	GN005123.1	Q2TBV5	63.9	335	341	395	6.18e-157	448	TF2H2_BOVIN	General transcription factor IIH subunit 2 (General transcription factor IIH polypeptide 2)	Bos taurus (Bovine)	nucleotide-excision repair [GO:0006289]; transcription by RNA polymerase II [GO:0006366]	zinc ion binding [GO:0008270]	core TFIIH complex portion of holo TFIIH complex [GO:0000438]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; transcription factor TFIIH holo complex [GO:0005675]	GO:0000438; GO:0005634; GO:0005675; GO:0006289; GO:0006366; GO:0008270; GO:0016607
GN005124	GN005124.1	Q96CS7	30.6	98	146	222	2.00e-16	75.9	PKHB2_HUMAN	Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2)	Homo sapiens (Human)	regulation of cell differentiation [GO:0045595]	phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]	membrane [GO:0016020]; recycling endosome membrane [GO:0055038]	GO:0005547; GO:0016020; GO:0045595; GO:0055038
GN005125	GN005125.1	Q8T062	32.2	270	295	1040	6.26e-46	169	NEP4_DROME	Neprilysin-4 (EC 3.4.24.11)	Drosophila melanogaster (Fruit fly)	protein processing [GO:0016485]; proteolysis [GO:0006508]	endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]	GO:0004175; GO:0004222; GO:0005576; GO:0005737; GO:0005886; GO:0006508; GO:0008237; GO:0016020; GO:0016485; GO:0016529
GN005126	GN005126.1	P45886	52.9	376	379	376	2.18e-138	402	ACT3_BACDO	Actin-3, muscle-specific (EC 3.6.4.-)	Bactrocera dorsalis (Oriental fruit fly) (Dacus dorsalis)	anatomical structure formation involved in morphogenesis [GO:0048646]; cell development [GO:0048468]	ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887; GO:0048468; GO:0048646
GN005127	GN005127.1	P02578	60.8	372	379	375	7.06e-166	471	ACT1_ACACA	Actin-1 (EC 3.6.4.-)	Acanthamoeba castellanii (Amoeba)	cell morphogenesis [GO:0000902]; phagocytosis [GO:0006909]; plasma membrane repair [GO:0001778]; response to cAMP [GO:0051591]	ATP hydrolysis activity [GO:0016887]	cell pole [GO:0060187]; cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; early phagosome [GO:0032009]; intranuclear rod [GO:0061836]; lamellipodium [GO:0030027]; phagocytic cup [GO:0001891]; phagolysosome [GO:0032010]	GO:0000902; GO:0001778; GO:0001891; GO:0005911; GO:0006909; GO:0016887; GO:0030027; GO:0030864; GO:0032009; GO:0032010; GO:0051591; GO:0060187; GO:0061836
GN005128	GN005128.1	P35432	46.8	370	373	375	2.20e-116	345	ACT1_ECHGR	Actin-1 (EC 3.6.4.-)	Echinococcus granulosus (Hydatid tapeworm)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN005129	GN005129.1	Q5SSL4	36.7	780	1329	859	1.84e-142	458	ABR_MOUSE	Active breakpoint cluster region-related protein	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; brain development [GO:0007420]; inner ear morphogenesis [GO:0042472]; intracellular signal transduction [GO:0035556]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of blood vessel remodeling [GO:0060313]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular extravasation [GO:0002692]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neutrophil degranulation [GO:0043314]; neuromuscular process controlling balance [GO:0050885]; positive regulation of phagocytosis [GO:0050766]; regulation of vascular permeability [GO:0043114]; response to lipopolysaccharide [GO:0032496]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]	axon [GO:0030424]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density, intracellular component [GO:0099092]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]	GO:0002692; GO:0005085; GO:0005096; GO:0005829; GO:0005886; GO:0007420; GO:0016020; GO:0030036; GO:0030336; GO:0030424; GO:0032496; GO:0035556; GO:0042472; GO:0043114; GO:0043197; GO:0043314; GO:0045202; GO:0050728; GO:0050766; GO:0050804; GO:0050885; GO:0060313; GO:0090630; GO:0098685; GO:0098978; GO:0099092
GN005130	GN005130.1	P91685	24.7	878	982	976	1.07e-27	124	GRM_DROME	Metabotropic glutamate receptor (DmGluRA)	Drosophila melanogaster (Fruit fly)	G protein-coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; long-term memory [GO:0007616]; male courtship behavior [GO:0008049]; neuromuscular junction development [GO:0007528]; regulation of synaptic transmission, glutamatergic [GO:0051966]; short-term memory [GO:0007614]; terminal button organization [GO:0072553]	cholesterol binding [GO:0015485]; G protein-coupled receptor activity [GO:0004930]; glutamate binding [GO:0016595]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]	G protein-coupled receptor homodimeric complex [GO:0038038]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0001641; GO:0004930; GO:0005886; GO:0007216; GO:0007528; GO:0007612; GO:0007614; GO:0007616; GO:0008049; GO:0008066; GO:0015485; GO:0016020; GO:0016595; GO:0038038; GO:0045121; GO:0051966; GO:0072553
GN005131	GN005131.1	Q9JMC1	38.0	345	345	1001	7.97e-65	224	PI5PA_RAT	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.36) (Inositol polyphosphate 5-phosphatase J) (Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase) (EC 3.1.3.56) (Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.56) (Proline-rich inositol polyphosphate 5-phosphatase)	Rattus norvegicus (Rat)	negative regulation of microtubule polymerization [GO:0031115]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; phosphatidylinositol dephosphorylation [GO:0046856]	inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]	cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; growth cone [GO:0030426]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	GO:0001726; GO:0004439; GO:0004445; GO:0005737; GO:0005886; GO:0010977; GO:0030426; GO:0031115; GO:0032587; GO:0033137; GO:0034485; GO:0043005; GO:0043198; GO:0046030; GO:0046856; GO:0052658; GO:0052659
GN005132	GN005132.1	P67998	64.2	503	489	525	2.09e-213	602	KS6B1_RABIT	Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA)	Oryctolagus cuniculus (Rabbit)	cellular response to growth factor stimulus [GO:0071363]; long-chain fatty acid import into cell [GO:0044539]; negative regulation of apoptotic process [GO:0043066]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of TORC2 signaling [GO:1903940]; peptidyl-serine phosphorylation [GO:0018105]; response to glucocorticoid [GO:0051384]; response to ketone [GO:1901654]; TOR signaling [GO:0031929]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; synapse [GO:0045202]	GO:0004672; GO:0004674; GO:0005524; GO:0005739; GO:0005741; GO:0018105; GO:0031929; GO:0043066; GO:0044539; GO:0045202; GO:0046627; GO:0051384; GO:0071363; GO:0106310; GO:1901654; GO:1903940
GN005133	GN005133.1	Q92616	51.9	2679	2669	2671	0.0	2551	GCN1_HUMAN	Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1)	Homo sapiens (Human)	cellular response to amino acid starvation [GO:0034198]; GCN2-mediated signaling [GO:0140469]; protein-RNA covalent cross-linking repair [GO:0160127]; regulation of translation [GO:0006417]; rescue of stalled cytosolic ribosome [GO:0072344]	cadherin binding [GO:0045296]; molecular adaptor activity [GO:0060090]; protein kinase regulator activity [GO:0019887]; protein serine/threonine kinase activator activity [GO:0043539]; RNA binding [GO:0003723]; stalled ribosome sensor activity [GO:0170011]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; ribosome [GO:0005840]	GO:0003723; GO:0005737; GO:0005829; GO:0005840; GO:0006417; GO:0008135; GO:0016020; GO:0019887; GO:0022626; GO:0034198; GO:0043539; GO:0045296; GO:0060090; GO:0072344; GO:0140469; GO:0160127; GO:0170011
GN005136	GN005136.1	Q9GKX6	38.9	321	384	342	2.61e-70	227	GALM_PIG	Galactose mutarotase (EC 5.1.3.3) (Aldose 1-epimerase)	Sus scrofa (Pig)	galactose catabolic process via UDP-galactose, Leloir pathway [GO:0033499]; glucose metabolic process [GO:0006006]	aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246]	cytoplasm [GO:0005737]	GO:0004034; GO:0005737; GO:0006006; GO:0030246; GO:0033499
GN005139	GN005139.1	A0A7M7H6R7	30.9	272	250	399	1.15e-29	117	FUTC_APIME	Lewis-type alpha-(1,3)-fucosyltransferase (EC 2.4.1.152) (Fucosyltransferase C) (AmFucTC)	Apis mellifera (Honeybee)	N-glycan processing [GO:0006491]	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0017083; GO:0032580
GN005142	GN005142.1	Q8TBY9	46.1	898	1119	1149	3.50e-293	853	CF251_HUMAN	Cilia- and flagella-associated protein 251 (WD repeat-containing protein 66)	Homo sapiens (Human)	cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]		axoneme [GO:0005930]; motile cilium [GO:0031514]; sperm end piece [GO:0097229]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]	GO:0003341; GO:0005930; GO:0030317; GO:0031514; GO:0036126; GO:0097225; GO:0097229
GN005143	GN005143.1	Q9NDJ2	44.7	945	2133	3198	1.13e-197	669	DOM_DROME	Chromatin remodeling protein domino (EC 3.6.4.-)	Drosophila melanogaster (Fruit fly)	chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; dendrite guidance [GO:0070983]; dendrite morphogenesis [GO:0048813]; DNA repair-dependent chromatin remodeling [GO:0140861]; hemopoiesis [GO:0030097]; male germ-line stem cell population maintenance [GO:0036098]; negative regulation of gene expression [GO:0010629]; negative regulation of hemocyte proliferation [GO:0035207]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; somatic stem cell population maintenance [GO:0035019]; transcription initiation-coupled chromatin remodeling [GO:0045815]; wing disc pattern formation [GO:0035222]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent H2AZ histone chaperone activity [GO:0140849]; histone chaperone activity [GO:0140713]	chromosome [GO:0005694]; histone acetyltransferase complex [GO:0000123]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]	GO:0000123; GO:0000381; GO:0000812; GO:0005524; GO:0005634; GO:0005694; GO:0006325; GO:0006338; GO:0007399; GO:0008094; GO:0010629; GO:0016887; GO:0030097; GO:0035019; GO:0035207; GO:0035222; GO:0035267; GO:0036098; GO:0045815; GO:0045893; GO:0048477; GO:0048813; GO:0070983; GO:0140658; GO:0140713; GO:0140849; GO:0140861
GN005147	GN005147.1	Q9JHI0	35.7	476	479	527	1.45e-64	220	MMP19_MOUSE	Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI)	Mus musculus (Mouse)	collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; luteolysis [GO:0001554]; ovarian follicle development [GO:0001541]; ovulation from ovarian follicle [GO:0001542]; proteolysis [GO:0006508]; response to cAMP [GO:0051591]; response to hormone [GO:0009725]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0001541; GO:0001542; GO:0001554; GO:0004222; GO:0005576; GO:0005886; GO:0006508; GO:0008270; GO:0009725; GO:0030198; GO:0030574; GO:0031012; GO:0051591
GN005149	GN005149.1	Q9UH65	24.5	241	771	585	3.40e-09	63.9	SWP70_HUMAN	Switch-associated protein 70 (SWAP-70)	Homo sapiens (Human)	actin filament bundle assembly [GO:0051017]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of mast cell chemotaxis [GO:0060754]; regulation of protein localization [GO:0032880]; regulation of small GTPase mediated signal transduction [GO:0051056]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	GO:0003677; GO:0005085; GO:0005509; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0007204; GO:0015629; GO:0030027; GO:0030835; GO:0032233; GO:0032880; GO:0033633; GO:0045296; GO:0051017; GO:0051056; GO:0060754; GO:0098794
GN005150	GN005150.1	O60671	67.1	219	221	282	1.01e-104	306	RAD1_HUMAN	Cell cycle checkpoint protein RAD1 (hRAD1) (Rad1-like DNA damage checkpoint protein)	Homo sapiens (Human)	cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; meiotic recombination checkpoint signaling [GO:0051598]; substantia nigra development [GO:0021762]	damaged DNA binding [GO:0003684]	checkpoint clamp complex [GO:0030896]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000077; GO:0003684; GO:0005634; GO:0005654; GO:0005694; GO:0006281; GO:0006974; GO:0021762; GO:0030896; GO:0051598; GO:0071479
GN005154	GN005154.1	Q9VGH7	43.3	1016	954	1193	4.05e-237	705	CLCN2_DROME	Chloride channel protein 2 (ClC-2) (DmClC-2) (Chloride channel-a)	Drosophila melanogaster (Fruit fly)	chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; renal water homeostasis [GO:0003091]; renal water transport [GO:0003097]; transepithelial chloride transport [GO:0030321]; transepithelial water transport [GO:0035377]	chloride channel activity [GO:0005254]; voltage-gated chloride channel activity [GO:0005247]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]	GO:0003091; GO:0003097; GO:0005247; GO:0005254; GO:0005886; GO:0006821; GO:0009925; GO:0015629; GO:0016324; GO:0030321; GO:0035377; GO:1902476
GN005155	GN005155.1	Q9H3D4	37.7	637	590	680	6.51e-104	331	P63_HUMAN	Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)	Homo sapiens (Human)	apoptotic process [GO:0006915]; DNA damage response [GO:0006974]; establishment of skin barrier [GO:0061436]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of somatic stem cell population maintenance [GO:1904674]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein tetramerization [GO:0051262]; regulation of apoptotic process [GO:0042981]; regulation of epidermal cell division [GO:0010482]; spermatogenesis [GO:0007283]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; WW domain binding [GO:0050699]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0002039; GO:0003677; GO:0003682; GO:0003684; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006915; GO:0006974; GO:0007283; GO:0008284; GO:0010482; GO:0030425; GO:0033147; GO:0042771; GO:0042802; GO:0042981; GO:0043565; GO:0045669; GO:0045747; GO:0045892; GO:0045893; GO:0045944; GO:0050699; GO:0051262; GO:0061436; GO:0097371; GO:1902808; GO:1904674; GO:1990841; GO:2000271; GO:2000773; GO:2001235
GN005157	GN005157.1	Q9P2S5	53.3	45	53	460	6.58e-11	58.2	WRP73_HUMAN	WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene)	Homo sapiens (Human)	microtubule anchoring at mitotic spindle pole body [GO:1990810]; mitotic spindle assembly [GO:0090307]; positive regulation of non-motile cilium assembly [GO:1902857]		centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; MWP complex [GO:1990811]	GO:0005737; GO:0005813; GO:0005814; GO:0005815; GO:0034451; GO:0036064; GO:0090307; GO:1902857; GO:1990810; GO:1990811
GN005158	GN005158.1	G5EFC3	27.7	466	451	558	6.06e-46	170	KCNAG_CAEEL	Potassium voltage-gated channel protein egl-36 (Egg-laying defective protein 36)	Caenorhabditis elegans	action potential [GO:0001508]; monoatomic ion transmembrane transport [GO:0034220]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic ion channel activity [GO:0005244]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005244; GO:0005251; GO:0008076; GO:0016020; GO:0032590; GO:0032809; GO:0034220; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN005164	GN005164.1	Q99L20	40.8	76	107	241	8.42e-11	59.7	GSTT3_MOUSE	Glutathione S-transferase theta-3 (EC 2.5.1.18)	Mus musculus (Mouse)	glutathione metabolic process [GO:0006749]	glutathione transferase activity [GO:0004364]	cytoplasm [GO:0005737]	GO:0004364; GO:0005737; GO:0006749
GN005168	GN005168.1	Q6DBQ8	38.8	209	207	211	3.67e-39	136	CPTP_DANRE	Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1) (CPTP)	Danio rerio (Zebrafish) (Brachydanio rerio)	ceramide 1-phosphate transport [GO:1902389]; ceramide transport [GO:0035627]; intermembrane lipid transfer [GO:0120009]; negative regulation of autophagy [GO:0010507]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]	ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]	GO:0005543; GO:0005640; GO:0005794; GO:0005829; GO:0005886; GO:0010008; GO:0010507; GO:0032691; GO:0035627; GO:0120009; GO:1900226; GO:1902387; GO:1902388; GO:1902389
GN005170	GN005170.1	Q68FT9	52.9	414	439	432	1.73e-154	447	SCLY_RAT	Selenocysteine lyase (EC 4.4.1.16)	Rattus norvegicus (Rat)	lipid metabolic process [GO:0006629]; negative regulation of cellular response to oxidative stress [GO:1900408]; response to insulin [GO:0032868]; selenium compound metabolic process [GO:0001887]	amino acid binding [GO:0016597]; protein homodimerization activity [GO:0042803]; selenocysteine lyase activity [GO:0009000]; vitamin B6 binding [GO:0070279]	catalytic complex [GO:1902494]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]	GO:0001887; GO:0005794; GO:0005829; GO:0006629; GO:0009000; GO:0016597; GO:0032868; GO:0042803; GO:0070279; GO:1900408; GO:1902494
GN005171	GN005171.1	O00329	30.5	505	524	1044	7.06e-57	208	PK3CD_HUMAN	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)	Homo sapiens (Human)	adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; B cell chemotaxis [GO:0035754]; B cell differentiation [GO:0030183]; B cell receptor signaling pathway [GO:0050853]; cell migration [GO:0016477]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; natural killer cell activation [GO:0030101]; natural killer cell chemotaxis [GO:0035747]; natural killer cell differentiation [GO:0001779]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokine production [GO:0001819]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil apoptotic process [GO:0033031]; protein phosphorylation [GO:0006468]; respiratory burst involved in defense response [GO:0002679]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell costimulation [GO:0031295]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor signaling pathway [GO:0038084]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]	cytosol [GO:0005829]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; plasma membrane [GO:0005886]	GO:0001779; GO:0001819; GO:0001938; GO:0002250; GO:0002551; GO:0002679; GO:0005829; GO:0005886; GO:0005942; GO:0005943; GO:0006468; GO:0006954; GO:0006955; GO:0007165; GO:0010595; GO:0010628; GO:0010818; GO:0016303; GO:0016477; GO:0030101; GO:0030183; GO:0030217; GO:0030335; GO:0030593; GO:0031295; GO:0033031; GO:0035005; GO:0035747; GO:0035754; GO:0036092; GO:0038084; GO:0042110; GO:0042113; GO:0043303; GO:0043491; GO:0045087; GO:0045766; GO:0046934; GO:0048015; GO:0050852; GO:0050853; GO:0060374; GO:0072672; GO:1905278
GN005175	GN005175.1	Q2M385	39.3	598	654	716	2.65e-142	434	MPEG1_HUMAN	Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2) [Cleaved into: Macrophage-expressed gene 1 protein, processed form]	Homo sapiens (Human)	antibacterial innate immune response [GO:0140367]; antigen processing and presentation of exogenous peptide antigen [GO:0002478]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; dendritic cell antigen processing and presentation [GO:0002468]	wide pore channel activity [GO:0022829]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; extracellular region [GO:0005576]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagolysosome membrane [GO:0061474]	GO:0002468; GO:0002478; GO:0005576; GO:0022829; GO:0030659; GO:0030670; GO:0031410; GO:0042590; GO:0042742; GO:0045335; GO:0050829; GO:0050830; GO:0061474; GO:0140367
GN005176	GN005176.1	Q5RBP9	38.0	582	727	716	3.53e-141	434	MPEG1_PONAB	Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2) [Cleaved into: Macrophage-expressed gene 1 protein, processed form]	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	antibacterial innate immune response [GO:0140367]; antigen processing and presentation of exogenous peptide antigen [GO:0002478]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; dendritic cell antigen processing and presentation [GO:0002468]	wide pore channel activity [GO:0022829]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagolysosome membrane [GO:0061474]	GO:0002468; GO:0002478; GO:0022829; GO:0030659; GO:0030670; GO:0031410; GO:0042590; GO:0042742; GO:0045335; GO:0050829; GO:0050830; GO:0061474; GO:0140367
GN005182	GN005182.1	Q5R5S1	37.8	484	478	621	5.93e-87	281	FBX21_PONAB	F-box only protein 21	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)		DNA binding [GO:0003677]		GO:0003677
GN005183	GN005183.1	Q969V4	52.4	401	402	418	2.23e-134	394	TEKT1_HUMAN	Tektin-1	Homo sapiens (Human)	cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317]		axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005634; GO:0005879; GO:0015630; GO:0030317; GO:0036126; GO:0060271; GO:0060294; GO:0160111
GN005185	GN005185.1	P0C872	49.3	225	296	316	1.91e-77	241	JMJD7_MOUSE	Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7 (EC 1.14.11.63) (EC 3.4.-.-) (JmjC domain-containing protein 7) (Jumonji domain-containing protein 7) (L-lysine (3S)-hydroxylase Jmjd7)	Mus musculus (Mouse)	protein hydroxylation [GO:0018126]	aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; monooxygenase activity [GO:0004497]; peptidyl-lysine 3-dioxygenase activity [GO:0106155]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004175; GO:0004177; GO:0004497; GO:0005634; GO:0005737; GO:0005829; GO:0018126; GO:0106155
GN005186	GN005186.1	Q99570	58.9	717	700	1358	1.96e-289	835	PI3R4_HUMAN	Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)	Homo sapiens (Human)	autophagosome maturation [GO:0097352]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; pexophagy [GO:0000425]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; protein phosphorylation [GO:0006468]; protein targeting to lysosome [GO:0006622]; protein targeting to vacuole [GO:0006623]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	autophagosome [GO:0005776]; axoneme [GO:0005930]; cytosol [GO:0005829]; late endosome [GO:0005770]; membrane [GO:0016020]; nucleus-vacuole junction [GO:0071561]; phagocytic vesicle membrane [GO:0030670]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]	GO:0000425; GO:0004672; GO:0004674; GO:0005524; GO:0005770; GO:0005776; GO:0005829; GO:0005930; GO:0006468; GO:0006622; GO:0006623; GO:0010506; GO:0016020; GO:0016236; GO:0016241; GO:0030670; GO:0032465; GO:0032801; GO:0034271; GO:0034272; GO:0035032; GO:0036092; GO:0042149; GO:0043491; GO:0045022; GO:0045324; GO:0071561; GO:0097352; GO:0106310
GN005188	GN005188.1	Q99570	43.8	682	671	1358	2.08e-158	494	PI3R4_HUMAN	Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)	Homo sapiens (Human)	autophagosome maturation [GO:0097352]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; pexophagy [GO:0000425]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; protein phosphorylation [GO:0006468]; protein targeting to lysosome [GO:0006622]; protein targeting to vacuole [GO:0006623]; receptor catabolic process [GO:0032801]; regulation of autophagy [GO:0010506]; regulation of cytokinesis [GO:0032465]; regulation of macroautophagy [GO:0016241]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	autophagosome [GO:0005776]; axoneme [GO:0005930]; cytosol [GO:0005829]; late endosome [GO:0005770]; membrane [GO:0016020]; nucleus-vacuole junction [GO:0071561]; phagocytic vesicle membrane [GO:0030670]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]	GO:0000425; GO:0004672; GO:0004674; GO:0005524; GO:0005770; GO:0005776; GO:0005829; GO:0005930; GO:0006468; GO:0006622; GO:0006623; GO:0010506; GO:0016020; GO:0016236; GO:0016241; GO:0030670; GO:0032465; GO:0032801; GO:0034271; GO:0034272; GO:0035032; GO:0036092; GO:0042149; GO:0043491; GO:0045022; GO:0045324; GO:0071561; GO:0097352; GO:0106310
GN005189	GN005189.1	Q4R7H0	42.2	270	643	618	6.26e-57	206	TTL10_MACFA	Protein polyglycylase TTLL10 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 10)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	protein polyglycylation [GO:0018094]	protein-glycine ligase activity [GO:0070735]; protein-glycine ligase activity, elongating [GO:0070737]	axoneme [GO:0005930]; cilium [GO:0005929]; microtubule cytoskeleton [GO:0015630]	GO:0005929; GO:0005930; GO:0015630; GO:0018094; GO:0070735; GO:0070737
GN005194	GN005194.1	Q0EAB5	27.8	266	247	390	1.11e-10	64.3	5HT1B_HORSE	5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B)	Equus caballus (Horse)	adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; bone remodeling [GO:0046849]; cellular response to alkaloid [GO:0071312]; cellular response to xenobiotic stimulus [GO:0071466]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of serotonin secretion [GO:0014063]; regulation of behavior [GO:0050795]; vasoconstriction [GO:0042310]	G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0004993; GO:0005886; GO:0007187; GO:0007198; GO:0007268; GO:0014063; GO:0030425; GO:0030594; GO:0042310; GO:0045202; GO:0046849; GO:0050795; GO:0071312; GO:0071466
GN005206	GN005206.1	A0A345BJN8	30.1	229	449	919	2.90e-23	106	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN005207	GN005207.1	A2VE54	34.5	290	361	457	3.57e-42	155	UN93A_BOVIN	N-acetylglucosamine transporter UNC93A (Protein unc-93 homolog A) (Unc-93A)	Bos taurus (Bovine)		N-acetylglucosamine transmembrane transporter activity [GO:0015572]	plasma membrane [GO:0005886]	GO:0005886; GO:0015572
GN005209	GN005209.1	Q710D3	58.3	60	100	458	1.83e-11	62.0	UN93A_MOUSE	N-acetylglucosamine transporter UNC93A (Protein unc-93 homolog A) (Unc-93A)	Mus musculus (Mouse)		N-acetylglucosamine transmembrane transporter activity [GO:0015572]	plasma membrane [GO:0005886]	GO:0005886; GO:0015572
GN005214	GN005214.1	Q23157	24.9	353	429	465	9.30e-25	109	INX11_CAEEL	Innexin-11 (Protein opu-11)	Caenorhabditis elegans		gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005921; GO:0055077
GN005215	GN005215.1	Q5UAW9	33.8	148	202	335	1.84e-12	68.2	GP157_HUMAN	G protein-coupled receptor 157	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; radial glial cell differentiation [GO:0060019]	G protein-coupled receptor activity [GO:0004930]	ciliary membrane [GO:0060170]	GO:0004930; GO:0007166; GO:0007189; GO:0007200; GO:0048512; GO:0060019; GO:0060170
GN005218	GN005218.1	Q8C206	32.1	134	194	330	7.13e-12	66.2	GP157_MOUSE	G protein-coupled receptor 157	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; radial glial cell differentiation [GO:0060019]	G protein-coupled receptor activity [GO:0004930]	ciliary membrane [GO:0060170]	GO:0004930; GO:0007166; GO:0007189; GO:0007200; GO:0048512; GO:0060019; GO:0060170
GN005221	GN005221.1	Q8TEL6	38.7	775	770	797	2.24e-165	500	TP4AP_HUMAN	Short transient receptor potential channel 4-associated protein (Trp4-associated protein) (Trpc4-associated protein) (Protein TAP1) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS)	Homo sapiens (Human)	calcium ion transmembrane transport [GO:0070588]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	calcium channel activity [GO:0005262]; phosphatase binding [GO:0019902]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0005262; GO:0005829; GO:0005886; GO:0006511; GO:0016567; GO:0019902; GO:0031464; GO:0048471; GO:0070588; GO:0080008; GO:0140627; GO:1990756
GN005222	GN005222.1	P08938	29.8	168	203	196	2.87e-09	57.8	PURP_CHICK	Purpurin	Gallus gallus (Chicken)		retinoid binding [GO:0005501]; retinol transmembrane transporter activity [GO:0034632]	interphotoreceptor matrix [GO:0033165]	GO:0005501; GO:0033165; GO:0034632
GN005224	GN005224.1	Q8R0A7	36.6	410	591	407	8.28e-64	218	K0513_MOUSE	Uncharacterized protein KIAA0513	Mus musculus (Mouse)				
GN005225	GN005225.1	Q32PH2	31.9	379	504	457	6.64e-39	150	TM143_BOVIN	Transmembrane protein 143	Bos taurus (Bovine)			membrane [GO:0016020]; mitochondrion [GO:0005739]	GO:0005739; GO:0016020
GN005226	GN005226.1	Q9Y248	63.9	183	184	185	1.07e-79	238	PSF2_HUMAN	DNA replication complex GINS protein PSF2 (GINS complex subunit 2)	Homo sapiens (Human)	DNA replication [GO:0006260]; double-strand break repair via break-induced replication [GO:0000727]		CMG complex [GO:0071162]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000727; GO:0000811; GO:0005634; GO:0005654; GO:0006260; GO:0071162
GN005228	GN005228.1	Q494W8	39.2	194	322	412	9.15e-34	131	CRFM7_HUMAN	CHRNA7-FAM7A fusion protein (CHRNA7-DR1) (D-10)	Homo sapiens (Human)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; excitatory postsynaptic potential [GO:0060079]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005230; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0050890; GO:0060079
GN005231	GN005231.1	P63115	40.3	72	86	530	2.33e-12	63.9	AAA1_MOUSE	Asc-type amino acid transporter 1 (Asc-1) (D-serine transporter) (Solute carrier family 7 member 10)	Mus musculus (Mouse)	D-alanine transmembrane transport [GO:0042941]; D-serine transmembrane transport [GO:0042942]; glycine transport [GO:0015816]; negative regulation of brown fat cell differentiation [GO:1903444]; neutral amino acid transport [GO:0015804]; positive regulation of synaptic transmission, glycinergic [GO:0060094]	L-amino acid transmembrane transporter activity [GO:0015179]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	apical dendrite [GO:0097440]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	GO:0005886; GO:0015175; GO:0015179; GO:0015804; GO:0015816; GO:0042941; GO:0042942; GO:0043025; GO:0060094; GO:0097440; GO:1903444
GN005232	GN005232.1	Q9GKT2	49.8	217	2145	333	3.81e-64	225	FXDC2_MACFA	Fatty acid hydroxylase domain-containing protein 2	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	lipid biosynthetic process [GO:0008610]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of protein phosphorylation [GO:0001934]	iron ion binding [GO:0005506]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0001934; GO:0005506; GO:0005737; GO:0008610; GO:0016020; GO:0045654
GN005234	GN005234.1	Q6DJ25	67.8	90	91	135	3.79e-40	132	MED10_XENTR	Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	regulation of transcription by RNA polymerase II [GO:0006357]	transcription coregulator activity [GO:0003712]	mediator complex [GO:0016592]	GO:0003712; GO:0006357; GO:0016592
GN005235	GN005235.1	Q5XKA2	46.9	145	153	232	3.56e-40	137	TIM21_XENLA	Mitochondrial import inner membrane translocase subunit Tim21 (TIM21-like protein, mitochondrial)	Xenopus laevis (African clawed frog)	protein import into mitochondrial matrix [GO:0030150]		TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	GO:0005744; GO:0030150
GN005236	GN005236.1	P56477	30.1	418	470	497	1.54e-41	157	IRF5_MOUSE	Interferon regulatory factor 5 (IRF-5)	Mus musculus (Mouse)	cellular response to muramyl dipeptide [GO:0071225]; cellular response to peptidoglycan [GO:0071224]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; innate immune response [GO:0045087]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 9 signaling pathway [GO:0034162]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein serine/threonine kinase binding [GO:0120283]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0002376; GO:0002720; GO:0005634; GO:0005737; GO:0006357; GO:0019221; GO:0019901; GO:0032481; GO:0032727; GO:0032728; GO:0032735; GO:0034162; GO:0042802; GO:0043065; GO:0043565; GO:0045087; GO:0045944; GO:0051607; GO:0070431; GO:0071224; GO:0071225; GO:0098586; GO:0120283; GO:1990837
GN005245	GN005245.1	Q149F1	46.8	124	149	553	1.54e-31	120	RUSD2_MOUSE	Pseudouridylate synthase RPUSD2 (EC 5.4.99.-) (EC 5.4.99.28) (EC 5.4.99.42) (RNA pseudouridylate synthase domain-containing protein 2)	Mus musculus (Mouse)	enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA pseudouridine synthesis [GO:1990481]; tRNA pseudouridine synthesis [GO:0031119]	pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029]; tRNA pseudouridine(31) synthase activity [GO:0160152]; tRNA pseudouridine(32) synthase activity [GO:0160151]		GO:0000455; GO:0003723; GO:0009982; GO:0031119; GO:0106029; GO:0160151; GO:0160152; GO:1990481
GN005247	GN005247.1	Q0MQI8	67.0	233	247	249	7.10e-109	317	NDUV2_GORGO	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 7.1.1.2) (NADH-ubiquinone oxidoreductase 24 kDa subunit)	Gorilla gorilla gorilla (Western lowland gorilla)	mitochondrial electron transport, NADH to ubiquinone [GO:0006120]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; respiratory chain complex I [GO:0045271]	GO:0005743; GO:0006120; GO:0008137; GO:0045271
GN005248	GN005248.1	Q3T0J3	40.3	233	240	251	2.06e-51	170	RM16_BOVIN	Large ribosomal subunit protein uL16m (39S ribosomal protein L16, mitochondrial) (L16mt) (MRP-L16)	Bos taurus (Bovine)	mitochondrial translation [GO:0032543]	rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005762; GO:0019843; GO:0032543
GN005249	GN005249.1	Q8WYQ5	43.0	430	682	773	1.52e-94	312	DGCR8_HUMAN	Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)	Homo sapiens (Human)	DNA damage response [GO:0006974]; positive regulation of pre-miRNA processing [GO:2000633]; primary miRNA processing [GO:0031053]	double-stranded RNA binding [GO:0003725]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; protein-RNA adaptor activity [GO:0140517]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; microprocessor complex [GO:0070877]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; site of double-strand break [GO:0035861]	GO:0003725; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006974; GO:0014069; GO:0016604; GO:0020037; GO:0030674; GO:0031053; GO:0035861; GO:0042802; GO:0042803; GO:0070877; GO:0070878; GO:0098978; GO:0140517; GO:2000633
GN005251	GN005251.1	Q2T9W3	29.5	437	534	558	5.68e-44	167	CCD63_BOVIN	Coiled-coil domain-containing protein 63	Bos taurus (Bovine)	cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]; spermatid development [GO:0007286]		axoneme [GO:0005930]	GO:0003341; GO:0005930; GO:0007286; GO:0036158
GN005252	GN005252.1	Q2YDN1	26.3	316	468	528	4.90e-21	99.4	GP161_BOVIN	G protein-coupled receptor 161	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; limb development [GO:0060173]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; regulation of neuron migration [GO:2001222]; skeletal system development [GO:0001501]	G protein-coupled receptor activity [GO:0004930]; signaling adaptor activity [GO:0035591]	non-motile cilium membrane [GO:0098804]; recycling endosome [GO:0055037]	GO:0001501; GO:0004930; GO:0007189; GO:0021549; GO:0030900; GO:0035591; GO:0055037; GO:0060173; GO:0098804; GO:1901621; GO:2001222
GN005253	GN005253.1	Q9JMA9	44.8	400	503	638	9.14e-115	355	S6A14_MOUSE	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Colonic system B0+ amino acid transporter CATB0+) (Solute carrier family 6 member 14)	Mus musculus (Mouse)	(R)-carnitine transmembrane transport [GO:1902270]; alanine transport [GO:0032328]; amino acid import across plasma membrane [GO:0089718]; beta-alanine transport [GO:0001762]; glycine import across plasma membrane [GO:1903804]; L-leucine import across plasma membrane [GO:1903801]; response to toxic substance [GO:0009636]; sodium ion transmembrane transport [GO:0035725]	(R)-carnitine transmembrane transporter activity [GO:1901235]; alanine transmembrane transporter activity [GO:0022858]; amine transmembrane transporter activity [GO:0005275]; aromatic amino acid transmembrane transporter activity [GO:0015173]; beta-alanine transmembrane transporter activity [GO:0001761]; branched-chain amino acid:sodium symporter activity [GO:0015657]; L-leucine transmembrane transporter activity [GO:0015190]; neutral, basic amino acid:sodium:chloride symporter activity [GO:0015374]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]	GO:0001761; GO:0001762; GO:0005275; GO:0005737; GO:0005886; GO:0009636; GO:0015173; GO:0015190; GO:0015374; GO:0015657; GO:0016324; GO:0022858; GO:0031526; GO:0032328; GO:0035725; GO:0044853; GO:0089718; GO:1901235; GO:1902270; GO:1903801; GO:1903804
GN005255	GN005255.1	Q5ZKG1	36.2	138	201	143	1.42e-14	70.9	RM51_CHICK	Large ribosomal subunit protein mL51 (39S ribosomal protein L51, mitochondrial) (L51mt) (MRP-L51)	Gallus gallus (Chicken)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005762; GO:0006412
GN005256	GN005256.1	Q9I993	37.7	366	364	526	1.06e-85	271	BCDO1_CHICK	Beta,beta-carotene 15,15'-dioxygenase (EC 1.13.11.63) (Beta-carotene dioxygenase 1) (Beta-carotene oxygenase 1)	Gallus gallus (Chicken)	beta-carotene metabolic process [GO:1901810]; carotene catabolic process [GO:0016121]; response to retinoic acid [GO:0032526]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]	beta-carotene 15,15'-dioxygenase activity [GO:0003834]; monooxygenase activity [GO:0004497]	cytosol [GO:0005829]	GO:0001523; GO:0003834; GO:0004497; GO:0005829; GO:0016121; GO:0032526; GO:0042572; GO:0042574; GO:1901810
GN005257	GN005257.1	Q29HG0	54.9	253	284	289	2.01e-88	268	PGAM5_DROPS	Serine/threonine-protein phosphatase Pgam5, mitochondrial (EC 3.1.3.16) (Phosphoglycerate mutase family member 5 homolog)	Drosophila pseudoobscura pseudoobscura (Fruit fly)	positive regulation of mitochondrial fission [GO:0090141]	protein serine/threonine phosphatase activity [GO:0004722]	mitochondrial outer membrane [GO:0005741]	GO:0004722; GO:0005741; GO:0090141
GN005265	GN005265.1	O93530	32.7	248	334	1436	6.44e-21	97.4	WRN_XENLA	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Focus-forming activity 1) (FFA-1) (Werner syndrome protein homolog) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Xenopus laevis (African clawed frog)	DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; four-way junction helicase activity [GO:0009378]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000723; GO:0000724; GO:0000781; GO:0003676; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006259; GO:0006260; GO:0008408; GO:0009378; GO:0016887; GO:0030145; GO:0032392; GO:0043138
GN005269	GN005269.1	Q28689	38.6	210	233	1564	1.16e-37	142	MRP2_RABIT	ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Epithelial basolateral chloride conductance regulator) (Multidrug resistance-associated protein 2)	Oryctolagus cuniculus (Rabbit)	bile acid and bile salt transport [GO:0015721]; leukotriene transport [GO:0071716]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]	apical plasma membrane [GO:0016324]	GO:0005524; GO:0008559; GO:0015431; GO:0015721; GO:0016324; GO:0016887; GO:0042626; GO:0071716
GN005270	GN005270.1	Q174D3	59.6	171	235	253	2.73e-59	190	MED19_AEDAE	Mediator of RNA polymerase II transcription subunit 19 (Mediator complex subunit 19)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	positive regulation of transcription by RNA polymerase II [GO:0045944]	transcription coregulator activity [GO:0003712]	mediator complex [GO:0016592]	GO:0003712; GO:0016592; GO:0045944
GN005273	GN005273.1	Q8GWA1	43.7	446	589	510	3.26e-112	347	NDA1_ARATH	Internal alternative NAD(P)H-ubiquinone oxidoreductase A1, mitochondrial (EC 1.6.5.9) (Internal alternative NADH dehydrogenase NDA1) (Internal non-phosphorylating NAD(P)H dehydrogenase 1) (AtNDI1) (NADH:ubiquinone reductase (non-electrogenic) NDA1)	Arabidopsis thaliana (Mouse-ear cress)	cellular response to light stimulus [GO:0071482]	NADH dehydrogenase (ubiquinone) (non-electrogenic) activity [GO:0120555]; NADH dehydrogenase activity [GO:0003954]; NADPH dehydrogenase activity [GO:0003959]; oxidoreductase activity [GO:0016491]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]	GO:0003954; GO:0003959; GO:0005739; GO:0005743; GO:0005759; GO:0005777; GO:0016491; GO:0071482; GO:0120555
GN005276	GN005276.1	P47727	52.1	167	174	277	3.92e-58	186	CBR1_RAT	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)	Rattus norvegicus (Rat)	epithelial cell differentiation [GO:0030855]; glucocorticoid metabolic process [GO:0008211]; ovulation from ovarian follicle [GO:0001542]; phylloquinone catabolic process [GO:0042376]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; prostaglandin catabolic process [GO:1905344]; response to estradiol [GO:0032355]; response to gonadotropin [GO:0034698]; response to lipopolysaccharide [GO:0032496]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; steroid catabolic process [GO:0006706]; vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH dehydrogenase (quinone) activity [GO:0008753]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E2 9-reductase activity [GO:0050221]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microvillus [GO:0005902]	GO:0001542; GO:0004090; GO:0005737; GO:0005829; GO:0005902; GO:0006706; GO:0006805; GO:0008106; GO:0008211; GO:0008753; GO:0016616; GO:0016655; GO:0030855; GO:0032355; GO:0032496; GO:0032570; GO:0033574; GO:0034698; GO:0042373; GO:0042376; GO:0047020; GO:0047021; GO:0050221; GO:0160163; GO:1905344; GO:2000379
GN005281	GN005281.1	A9XE49	30.2	159	191	200	1.82e-10	60.8	IL17L_MAGGI	Interleukin 17-like protein (CgIL-17)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		cytokine activity [GO:0005125]	extracellular region [GO:0005576]	GO:0005125; GO:0005576
GN005285	GN005285.1	P61406	44.7	998	1684	1418	5.63e-217	682	EST1A_MOUSE	Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog)	Mus musculus (Mouse)	negative regulation of telomere capping [GO:1904354]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of telomere maintenance [GO:0032204]	DNA polymerase binding [GO:0070182]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]; telomerase RNA binding [GO:0070034]; telomeric repeat DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; telomerase holoenzyme complex [GO:0005697]	GO:0000184; GO:0000781; GO:0003723; GO:0004521; GO:0005634; GO:0005697; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0032204; GO:0035145; GO:0036064; GO:0042162; GO:0043021; GO:0070034; GO:0070182; GO:1904354
GN005286	GN005286.1	Q28D99	54.9	474	557	511	4.35e-195	558	GADL1_XENTR	Acidic amino acid decarboxylase GADL1 (Aspartate 1-decarboxylase) (ADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (EC 4.1.1.29) (Glutamate decarboxylase-like protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		aspartate 1-decarboxylase activity [GO:0004068]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170]; sulfinoalanine decarboxylase activity [GO:0004782]	cytoplasm [GO:0005737]	GO:0004068; GO:0004782; GO:0005737; GO:0016831; GO:0030170
GN005288	GN005288.1	Q96S79	52.5	198	209	203	4.62e-70	215	RSLAB_HUMAN	Ras-like protein family member 10B (EC 3.6.5.2) (Ras-like protein VTS58635) (Ras-related protein 17) (RRP17)	Homo sapiens (Human)	positive regulation of peptide hormone secretion [GO:0090277]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]	GO:0003050; GO:0003924; GO:0003925; GO:0005525; GO:0005886; GO:0090277
GN005289	GN005289.1	O54992	33.7	184	177	473	6.69e-19	86.3	MAPK5_MOUSE	MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAPK-5) (EC 2.7.11.1)	Mus musculus (Mouse)	negative regulation of TOR signaling [GO:0032007]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; Ras protein signal transduction [GO:0007265]; regulation of translation [GO:0006417]; stress-induced premature senescence [GO:0090400]	ATP binding [GO:0005524]; mitogen-activated protein kinase binding [GO:0051019]; p53 binding [GO:0002039]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; septin cytoskeleton [GO:0032156]	GO:0002039; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006417; GO:0007265; GO:0032007; GO:0032156; GO:0032206; GO:0032991; GO:0045944; GO:0046777; GO:0051019; GO:0060999; GO:0090400; GO:0106310
GN005290	GN005290.1	A4QNN3	35.7	445	644	519	2.30e-79	264	UBP30_XENTR	Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mitochondrial fusion [GO:0008053]; negative regulation of mitophagy [GO:1901525]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K6-linked deubiquitination [GO:0044313]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0004197; GO:0004843; GO:0005739; GO:0005741; GO:0008053; GO:0016579; GO:0035871; GO:0044313; GO:1901525
GN005292	GN005292.1	P34748	36.1	97	200	133	4.61e-12	63.9	RT23_CAEEL	Small ribosomal subunit protein mS23 (28S ribosomal protein S23, mitochondrial)	Caenorhabditis elegans	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005763; GO:0006412
GN005293	GN005293.1	Q90476	51.1	452	470	405	9.50e-122	364	LHX1_DANRE	LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1)	Danio rerio (Zebrafish) (Brachydanio rerio)	anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior axis specification [GO:0009948]; anterior/posterior pattern specification [GO:0009952]; cell-cell signaling [GO:0007267]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell-granule cell precursor cell signaling [GO:0021937]; cerebellum development [GO:0021549]; comma-shaped body morphogenesis [GO:0072049]; dorsal spinal cord interneuron posterior axon guidance [GO:0097379]; dorsal/ventral pattern formation [GO:0009953]; ectoderm formation [GO:0001705]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; endoderm formation [GO:0001706]; epithelium development [GO:0060429]; forebrain regionalization [GO:0021871]; gastrulation with mouth forming second [GO:0001702]; head development [GO:0060322]; kidney development [GO:0001822]; lateral motor column neuron migration [GO:0097477]; motor neuron axon guidance [GO:0008045]; negative regulation of DNA-templated transcription [GO:0045892]; nephric duct morphogenesis [GO:0072178]; neuron differentiation [GO:0030182]; paramesonephric duct development [GO:0061205]; pattern specification process [GO:0007389]; positive regulation of anterior head development [GO:2000744]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; post-embryonic development [GO:0009791]; primitive streak formation [GO:0090009]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; renal vesicle morphogenesis [GO:0072077]; retina layer formation [GO:0010842]; S-shaped body morphogenesis [GO:0072050]; spinal cord association neuron differentiation [GO:0021527]; transcription by RNA polymerase II [GO:0006366]; ureteric bud development [GO:0001657]; urogenital system development [GO:0001655]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000977; GO:0000981; GO:0001655; GO:0001657; GO:0001702; GO:0001705; GO:0001706; GO:0001822; GO:0003700; GO:0005634; GO:0006357; GO:0006366; GO:0007267; GO:0007389; GO:0008045; GO:0008270; GO:0009653; GO:0009791; GO:0009880; GO:0009948; GO:0009952; GO:0009953; GO:0010468; GO:0010842; GO:0021527; GO:0021549; GO:0021702; GO:0021871; GO:0021937; GO:0030182; GO:0032991; GO:0040019; GO:0045892; GO:0045893; GO:0048646; GO:0060059; GO:0060322; GO:0060429; GO:0061205; GO:0072049; GO:0072050; GO:0072077; GO:0072178; GO:0090009; GO:0090190; GO:0097379; GO:0097477; GO:2000543; GO:2000744; GO:2000768
GN005294	GN005294.1	Q3U435	41.7	444	597	615	1.03e-100	321	MMP25_MOUSE	Matrix metalloproteinase-25 (MMP-25) (EC 3.4.24.-)	Mus musculus (Mouse)	collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; hard palate development [GO:0060022]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; peptidase activator activity [GO:0016504]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; plasma membrane [GO:0005886]	GO:0004222; GO:0005886; GO:0006508; GO:0008270; GO:0009986; GO:0016504; GO:0030198; GO:0030574; GO:0031012; GO:0060022
GN005296	GN005296.1	Q24155	25.9	147	156	226	3.09e-13	67.8	TRUNK_DROME	Protein trunk	Drosophila melanogaster (Fruit fly)	negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell differentiation [GO:0045596]; terminal region determination [GO:0007362]; torso signaling pathway [GO:0008293]	receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; torso binding [GO:0005122]	extracellular region [GO:0005576]	GO:0005102; GO:0005122; GO:0005576; GO:0007362; GO:0008293; GO:0030514; GO:0045596; GO:0048018
GN005300	GN005300.1	Q8BZT7	38.9	126	353	504	1.16e-28	119	PA2G3_MOUSE	Group 3 secretory phospholipase A2 (EC 3.1.1.4) (Group III secretory phospholipase A2) (GIII sPLA2) (sPLA2-III) (Phosphatidylcholine 2-acylhydrolase 3)	Mus musculus (Mouse)	acrosome assembly [GO:0001675]; arachidonate secretion [GO:0050482]; cell development [GO:0048468]; cell maturation [GO:0048469]; cilium assembly [GO:0060271]; high-density lipoprotein particle remodeling [GO:0034375]; lipoxygenase pathway [GO:0019372]; low-density lipoprotein particle remodeling [GO:0034374]; macrophage activation [GO:0042116]; mast cell degranulation [GO:0043303]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine metabolic process [GO:0046337]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of histamine secretion by mast cell [GO:1903595]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of mast cell differentiation [GO:0060376]; positive regulation of neuron projection development [GO:0010976]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of prostaglandin secretion [GO:0032308]; production of molecular mediator involved in inflammatory response [GO:0002532]; regulation of endocytic recycling [GO:2001135]; sperm axoneme assembly [GO:0007288]	A2-type glycerophospholipase activity [GO:0004623]; glycerophospholipase activity [GO:0004620]	centriole [GO:0005814]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	GO:0001675; GO:0002532; GO:0004620; GO:0004623; GO:0005576; GO:0005814; GO:0005886; GO:0006644; GO:0006658; GO:0007288; GO:0010629; GO:0010744; GO:0010976; GO:0019372; GO:0031394; GO:0032308; GO:0034374; GO:0034375; GO:0042116; GO:0043303; GO:0043524; GO:0046337; GO:0046470; GO:0046471; GO:0046473; GO:0046488; GO:0048468; GO:0048469; GO:0050482; GO:0055037; GO:0060271; GO:0060376; GO:1900017; GO:1900222; GO:1903595; GO:2001135
GN005301	GN005301.1	Q9CWK3	37.4	358	381	342	6.47e-56	189	CD2B2_MOUSE	CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2)	Mus musculus (Mouse)		ribonucleoprotein complex binding [GO:0043021]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U5 snRNP [GO:0005682]	GO:0001650; GO:0005634; GO:0005654; GO:0005681; GO:0005682; GO:0005829; GO:0016607; GO:0043021
GN005303	GN005303.1	A5YKK6	60.4	2437	2741	2376	0.0	2696	CNOT1_HUMAN	CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1)	Homo sapiens (Human)	miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of stem cell population maintenance [GO:2000036]; trophectodermal cell differentiation [GO:0001829]	armadillo repeat domain binding [GO:0070016]; molecular adaptor activity [GO:0060090]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoic acid receptor binding [GO:0042974]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; peroxisomal membrane [GO:0005778]	GO:0000122; GO:0000288; GO:0000289; GO:0000932; GO:0001829; GO:0003723; GO:0005576; GO:0005634; GO:0005778; GO:0005829; GO:0010606; GO:0016020; GO:0017148; GO:0019904; GO:0030014; GO:0030015; GO:0030331; GO:0033147; GO:0035195; GO:0042974; GO:0048387; GO:0060090; GO:0060213; GO:0061014; GO:0070016; GO:1900153; GO:2000036
GN005304	GN005304.1	P83310	24.2	302	266	295	3.32e-12	68.6	RDPA_DELAC	(R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase (RdpA) (EC 1.14.11.44) ((R)-dichlorprop/(R)-mecoprop dioxygenase) (Alpha-ketoglutarate-dependent dioxygenase) (Dichlorprop/alpha-ketoglutarate-dioxygenase) (Mecoprop/alpha-ketoglutarate-dioxygenase)	Delftia acidovorans (Pseudomonas acidovorans) (Comamonas acidovorans)		2-oxoglutarate-dependent dioxygenase activity [GO:0016706]	cytoplasm [GO:0005737]	GO:0005737; GO:0016706
GN005305	GN005305.1	Q9BUN8	60.1	248	253	251	3.53e-111	323	DERL1_HUMAN	Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)	Homo sapiens (Human)	cellular response to misfolded protein [GO:0071218]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511]	ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; MHC class I protein binding [GO:0042288]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; signal recognition particle binding [GO:0005047]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-specific protease binding [GO:1990381]	ATPase complex [GO:1904949]; cytoplasm [GO:0005737]; Derlin-1 retrotranslocation complex [GO:0036513]; Derlin-1-VIMP complex [GO:0036502]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; late endosome [GO:0005770]; membrane [GO:0016020]	GO:0002020; GO:0005047; GO:0005737; GO:0005769; GO:0005770; GO:0005783; GO:0005789; GO:0006511; GO:0006986; GO:0016020; GO:0030968; GO:0030970; GO:0031398; GO:0031625; GO:0031648; GO:0036502; GO:0036503; GO:0036513; GO:0038023; GO:0042288; GO:0042802; GO:0043161; GO:0044322; GO:0044877; GO:0045184; GO:0051117; GO:0071218; GO:1904949; GO:1990381
GN005306	GN005306.1	Q6DDI6	62.0	461	444	1089	3.71e-204	597	TBC31_XENLA	TBC1 domain family member 31	Xenopus laevis (African clawed frog)	cilium assembly [GO:0060271]	molecular adaptor activity [GO:0060090]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]	GO:0005813; GO:0034451; GO:0036064; GO:0060090; GO:0060271
GN005307	GN005307.1	Q99NE9	26.5	151	300	378	1.13e-11	68.2	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN005308	GN005308.1	Q6DEY8	40.7	460	464	1088	8.80e-74	254	TBC31_XENTR	TBC1 domain family member 31	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cilium assembly [GO:0060271]	molecular adaptor activity [GO:0060090]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]	GO:0005813; GO:0034451; GO:0036064; GO:0060090; GO:0060271
GN005309	GN005309.1	Q6ZFT5	54.2	284	337	325	9.86e-109	323	KPRS4_ORYSJ	Ribose-phosphate pyrophosphokinase 4 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 4)	Oryza sativa subsp. japonica (Rice)	5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; purine nucleotide biosynthetic process [GO:0006164]	magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749]	cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189]	GO:0000287; GO:0002189; GO:0004749; GO:0005737; GO:0006015; GO:0006164
GN005310	GN005310.1	Q3V2J0	46.1	217	371	292	4.17e-61	201	CBAR2_MOUSE	CBY1-interacting BAR domain-containing protein 2 (Protein FAM92B)	Mus musculus (Mouse)	cilium assembly [GO:0060271]		centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]	GO:0005814; GO:0035869; GO:0036064; GO:0060271
GN005311	GN005311.1	Q6PFJ7	36.4	492	498	791	1.69e-90	296	NSMA3_DANRE	Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III)	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; glycerophospholipid catabolic process [GO:0046475]; sphingomyelin catabolic process [GO:0006685]	sphingomyelin phosphodiesterase activity [GO:0004767]; sphingomyelin phosphodiesterase D activity [GO:0050290]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; sarcolemma [GO:0042383]	GO:0000139; GO:0004767; GO:0005635; GO:0005783; GO:0005789; GO:0006685; GO:0042383; GO:0046475; GO:0046513; GO:0050290; GO:0071356
GN005312	GN005312.1	Q5BIR5	45.8	373	379	374	9.81e-98	298	SPB8_BOVIN	Serpin B8	Bos taurus (Bovine)		serine-type endopeptidase inhibitor activity [GO:0004867]	cytoplasm [GO:0005737]	GO:0004867; GO:0005737
GN005314	GN005314.1	Q8IYL2	38.4	99	111	757	1.19e-14	71.6	TRM44_HUMAN	Probable tRNA (uracil-O(2)-)-methyltransferase (EC 2.1.1.211) (Methyltransferase-like protein 19)	Homo sapiens (Human)	tRNA methylation [GO:0030488]	metal ion binding [GO:0046872]; tRNA (uridine) methyltransferase activity [GO:0016300]; tRNA(Ser) (uridine(44)-2'-O-ribose)-methyltransferase activity [GO:0141101]	cytoplasm [GO:0005737]	GO:0005737; GO:0016300; GO:0030488; GO:0046872; GO:0141101
GN005315	GN005315.1	Q8K0U4	28.7	390	359	675	2.39e-37	145	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN005316	GN005316.1	Q8K0U4	28.4	387	446	675	1.56e-36	145	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN005317	GN005317.1	O43301	30.3	495	617	675	3.01e-47	179	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN005318	GN005318.1	P05099	25.8	423	670	493	1.03e-36	147	MATN1_CHICK	Matrilin-1 (Cartilage matrix protein)	Gallus gallus (Chicken)		calcium ion binding [GO:0005509]	extracellular matrix [GO:0031012]	GO:0005509; GO:0031012
GN005319	GN005319.1	O61492	64.2	436	425	438	3.60e-181	514	FLOT2_DROME	Flotillin-2	Drosophila melanogaster (Fruit fly)	cell adhesion [GO:0007155]; melanotic encapsulation of foreign target [GO:0035011]; positive regulation of filopodium assembly [GO:0051491]; protein localization to plasma membrane [GO:0072659]; regulation of myoblast differentiation [GO:0045661]	protease binding [GO:0002020]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; plasma membrane [GO:0005886]	GO:0002020; GO:0005198; GO:0005737; GO:0005829; GO:0005886; GO:0007155; GO:0016600; GO:0031410; GO:0035011; GO:0045661; GO:0051491; GO:0072659
GN005320	GN005320.1	Q9JM76	75.3	158	177	178	1.59e-80	239	ARPC3_MOUSE	Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)	Mus musculus (Mouse)	Arp2/3 complex-mediated actin nucleation [GO:0034314]; regulation of synaptic vesicle endocytosis [GO:1900242]	actin filament binding [GO:0051015]; structural constituent of cytoskeleton [GO:0005200]	Arp2/3 protein complex [GO:0005885]; cell leading edge [GO:0031252]; filamentous actin [GO:0031941]; growth cone leading edge [GO:0061850]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0005200; GO:0005634; GO:0005885; GO:0030027; GO:0031252; GO:0031941; GO:0034314; GO:0035861; GO:0051015; GO:0061850; GO:1900242
GN005321	GN005321.1	Q4PF70	56.5	46	61	281	2.82e-11	59.3	GPN3_MYCMD	GPN-loop GTPase 3 (EC 3.6.5.-)	Mycosarcoma maydis (Corn smut fungus) (Ustilago maydis)	mitotic sister chromatid cohesion [GO:0007064]; protein import into nucleus [GO:0006606]	GTPase activity [GO:0003924]		GO:0003924; GO:0006606; GO:0007064
GN005322	GN005322.1	Q1RMV0	50.8	648	620	640	3.58e-164	486	PEX5_BOVIN	Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)	Bos taurus (Bovine)	cellular response to reactive oxygen species [GO:0034614]; negative regulation of protein-containing complex assembly [GO:0031333]; pexophagy [GO:0000425]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; protein tetramerization [GO:0051262]	peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome membrane targeting sequence binding [GO:0033328]; protein carrier activity [GO:0140597]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	GO:0000425; GO:0005052; GO:0005777; GO:0005778; GO:0005782; GO:0005794; GO:0005829; GO:0006625; GO:0016558; GO:0016560; GO:0016561; GO:0016562; GO:0030674; GO:0031267; GO:0031333; GO:0032991; GO:0033328; GO:0034614; GO:0044721; GO:0045046; GO:0051262; GO:0140597
GN005324	GN005324.1	A0JMP0	40.5	400	568	655	2.05e-98	315	PGGHG_DANRE	Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107) (Acid trehalase-like protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	carbohydrate metabolic process [GO:0005975]	protein-glucosylgalactosylhydroxylysine glucosidase activity [GO:0047402]	cytosol [GO:0005829]	GO:0005829; GO:0005975; GO:0047402
GN005325	GN005325.1	O00222	31.3	850	1028	908	3.65e-112	372	GRM8_HUMAN	Metabotropic glutamate receptor 8 (mGluR8)	Homo sapiens (Human)	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; regulation of synaptic transmission, glutamatergic [GO:0051966]; visual perception [GO:0007601]	G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]	plasma membrane [GO:0005886]	GO:0001642; GO:0004930; GO:0005886; GO:0007193; GO:0007196; GO:0007216; GO:0007601; GO:0008066; GO:0051966
GN005329	GN005329.1	Q5PQ76	60.8	171	188	184	5.62e-71	216	CA050_XENLA	Uncharacterized protein C1orf50 homolog	Xenopus laevis (African clawed frog)				
GN005330	GN005330.1	P35408	29.4	323	332	488	4.28e-32	128	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of stress fiber assembly [GO:0051492]; response to mechanical stimulus [GO:0009612]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0009612; GO:0016020; GO:0033624; GO:0034695; GO:0042093; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070371; GO:0071260; GO:0071380; GO:2000420
GN005332	GN005332.1	P35408	26.6	323	336	488	9.72e-26	110	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of stress fiber assembly [GO:0051492]; response to mechanical stimulus [GO:0009612]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0009612; GO:0016020; GO:0033624; GO:0034695; GO:0042093; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070371; GO:0071260; GO:0071380; GO:2000420
GN005333	GN005333.1	P21731	27.2	309	322	343	2.63e-20	93.2	TA2R_HUMAN	Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to lipopolysaccharide [GO:0071222]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of vasoconstriction [GO:0045907]; response to ethanol [GO:0045471]; response to nutrient [GO:0007584]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]	guanyl-nucleotide exchange factor activity [GO:0005085]; thromboxane A2 receptor activity [GO:0004961]	acrosomal vesicle [GO:0001669]; plasma membrane [GO:0005886]	GO:0001669; GO:0004961; GO:0005085; GO:0005886; GO:0006954; GO:0007186; GO:0007189; GO:0007204; GO:0007584; GO:0009410; GO:0030194; GO:0033574; GO:0045471; GO:0045766; GO:0045777; GO:0045907; GO:0071222; GO:0090051
GN005334	GN005334.1	P35408	27.2	323	330	488	7.05e-27	113	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of stress fiber assembly [GO:0051492]; response to mechanical stimulus [GO:0009612]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0009612; GO:0016020; GO:0033624; GO:0034695; GO:0042093; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070371; GO:0071260; GO:0071380; GO:2000420
GN005338	GN005338.1	A3DH97	35.6	365	445	760	1.97e-64	224	RSGI6_ACET2	Anti-sigma-I factor RsgI6 (Endo-1,4-beta-xylanase) (EC 3.2.1.8)	Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)	xylan catabolic process [GO:0045493]	endo-1,4-beta-xylanase activity [GO:0031176]	plasma membrane [GO:0005886]	GO:0005886; GO:0031176; GO:0045493
GN005339	GN005339.1	Q56R14	21.8	340	738	1091	7.15e-11	69.7	TRI33_XENLA	E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)	Xenopus laevis (African clawed frog)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0008270; GO:0016567; GO:0061630
GN005341	GN005341.1	Q8VDP6	54.3	210	214	213	4.90e-78	236	CDIPT_MOUSE	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase)	Mus musculus (Mouse)	CDP-diacylglycerol metabolic process [GO:0046341]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipid biosynthetic process [GO:0008654]	alcohol binding [GO:0043178]; carbohydrate binding [GO:0030246]; CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity [GO:0003881]; diacylglycerol binding [GO:0019992]; manganese ion binding [GO:0030145]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0003881; GO:0005789; GO:0005886; GO:0006661; GO:0008654; GO:0016020; GO:0019992; GO:0030145; GO:0030246; GO:0043178; GO:0046341
GN005346	GN005346.1	A0A1S4GHV7	34.4	314	369	493	2.14e-43	160	FUTA_ANOGA	Core alpha-(1,3)-fucosyltransferase (EC 2.4.1.214) (Fucosyltransferase A) (AgFucTA)	Anopheles gambiae (African malaria mosquito)	N-glycan processing [GO:0006491]	glycoprotein 3-alpha-L-fucosyltransferase activity [GO:0018392]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0018392; GO:0032580
GN005347	GN005347.1	A0A1S4GHV7	28.3	297	308	493	1.05e-25	109	FUTA_ANOGA	Core alpha-(1,3)-fucosyltransferase (EC 2.4.1.214) (Fucosyltransferase A) (AgFucTA)	Anopheles gambiae (African malaria mosquito)	N-glycan processing [GO:0006491]	glycoprotein 3-alpha-L-fucosyltransferase activity [GO:0018392]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0018392; GO:0032580
GN005348	GN005348.1	A0A7M7H6R7	31.3	320	346	399	6.64e-38	142	FUTC_APIME	Lewis-type alpha-(1,3)-fucosyltransferase (EC 2.4.1.152) (Fucosyltransferase C) (AmFucTC)	Apis mellifera (Honeybee)	N-glycan processing [GO:0006491]	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0017083; GO:0032580
GN005349	GN005349.1	Q7QF91	32.2	267	356	405	2.68e-27	114	FUTC_ANOGA	Lewis-type alpha-(1,3)-fucosyltransferase (EC 2.4.1.152) (Fucosyltransferase C) (AgFucTC)	Anopheles gambiae (African malaria mosquito)	N-glycan processing [GO:0006491]	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity [GO:0017083]; alpha-(1->3)-fucosyltransferase activity [GO:0046920]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0017083; GO:0032580; GO:0046920
GN005352	GN005352.1	Q9DGB6	24.6	767	682	781	9.07e-38	154	TLR22_CHICK	Toll-like receptor 2 type-2	Gallus gallus (Chicken)	detection of bacterial lipoprotein [GO:0042494]; immune response [GO:0006955]; inflammatory response [GO:0006954]; toll-like receptor signaling pathway [GO:0002224]	signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497]	plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0002224; GO:0004888; GO:0005886; GO:0006954; GO:0006955; GO:0038023; GO:0042494; GO:0042497; GO:0043235
GN005353	GN005353.1	Q0ZUL9	25.0	672	704	789	4.83e-33	139	TLR6_DASNO	Toll-like receptor 6 (CD antigen CD286)	Dasypus novemcinctus (Nine-banded armadillo)	cellular response to diacyl bacterial lipopeptide [GO:0071726]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; toll-like receptor signaling pathway [GO:0002224]	identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	GO:0002224; GO:0004888; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0030670; GO:0032731; GO:0035355; GO:0035663; GO:0042802; GO:0045121; GO:0071723; GO:0071726; GO:1900227
GN005356	GN005356.1	Q9DGB6	27.4	343	396	781	2.57e-32	132	TLR22_CHICK	Toll-like receptor 2 type-2	Gallus gallus (Chicken)	detection of bacterial lipoprotein [GO:0042494]; immune response [GO:0006955]; inflammatory response [GO:0006954]; toll-like receptor signaling pathway [GO:0002224]	signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497]	plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0002224; GO:0004888; GO:0005886; GO:0006954; GO:0006955; GO:0038023; GO:0042494; GO:0042497; GO:0043235
GN005357	GN005357.1	Q7Z7E8	32.9	167	185	422	1.06e-19	88.6	UB2Q1_HUMAN	Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Protein NICE-5) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1)	Homo sapiens (Human)	protein polyubiquitination [GO:0000209]	ubiquitin conjugating enzyme activity [GO:0061631]	cytosol [GO:0005829]; filopodium [GO:0030175]; nucleus [GO:0005634]	GO:0000209; GO:0005634; GO:0005829; GO:0030175; GO:0061631
GN005358	GN005358.1	Q8CHP0	43.2	266	572	950	8.30e-28	122	ZC3H3_MOUSE	Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor)	Mus musculus (Mouse)	mRNA 3'-end processing [GO:0031124]; positive regulation of activin receptor signaling pathway [GO:0032927]	metal ion binding [GO:0046872]; R-SMAD binding [GO:0070412]; SMAD binding [GO:0046332]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleus [GO:0005634]	GO:0005634; GO:0005847; GO:0031124; GO:0032927; GO:0046332; GO:0046872; GO:0070412
GN005359	GN005359.1	Q4U1U2	67.2	67	322	289	1.53e-15	79.0	MAFA_XENTR	Transcription factor MafA	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	insulin secretion [GO:0030073]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0009749; GO:0030073
GN005360	GN005360.1	Q5R9W5	55.1	207	214	414	6.87e-77	239	WWOX_PONAB	WW domain-containing oxidoreductase (EC 1.1.1.-)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	cellular response to transforming growth factor beta stimulus [GO:0071560]; negative regulation of Wnt signaling pathway [GO:0030178]	enzyme binding [GO:0019899]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0005764; GO:0005794; GO:0019899; GO:0030178; GO:0071560
GN005363	GN005363.1	Q9U8W8	42.9	154	249	292	2.07e-33	125	TL5A_TACTR	Techylectin-5A	Tachypleus tridentatus (Japanese horseshoe crab)	cell-cell adhesion [GO:0098609]	carbohydrate binding [GO:0030246]	extracellular region [GO:0005576]	GO:0005576; GO:0030246; GO:0098609
GN005364	GN005364.1	A7T1N0	24.5	1153	1451	1551	3.27e-87	317	TMP2L_NEMVE	Transient receptor potential cation channel subfamily M member-like 2 (nvTRPM2)	Nematostella vectensis (Starlet sea anemone)	calcium ion transmembrane transport [GO:0070588]; sodium ion transmembrane transport [GO:0035725]	ADP-ribose diphosphatase activity [GO:0047631]; ligand-gated calcium channel activity [GO:0099604]; ligand-gated sodium channel activity [GO:0015280]	plasma membrane [GO:0005886]	GO:0005886; GO:0015280; GO:0035725; GO:0047631; GO:0070588; GO:0099604
GN005365	GN005365.1	Q9P2T1	86.3	182	188	348	5.08e-111	323	GMPR2_HUMAN	GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)	Homo sapiens (Human)	GMP metabolic process [GO:0046037]	GMP reductase activity [GO:0003920]	cytosol [GO:0005829]; GMP reductase complex [GO:1902560]	GO:0003920; GO:0005829; GO:0046037; GO:1902560
GN005368	GN005368.1	Q8NCC3	48.0	373	381	412	1.18e-124	368	PAG15_HUMAN	Lysosomal phospholipase A and acyltransferase (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) (Phospholipase A2 group XV) (PLA2G15)	Homo sapiens (Human)	ceramide metabolic process [GO:0006672]; diacylglycerol biosynthetic process [GO:0006651]; fatty acid catabolic process [GO:0009062]; glycerophospholipid metabolic process [GO:0006650]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylethanolamine catabolic process [GO:0046338]; phosphatidylglycerol metabolic process [GO:0046471]; phosphatidylserine metabolic process [GO:0006658]; phospholipid metabolic process [GO:0006644]	A2-type glycerophospholipase activity [GO:0004623]; acylglycerol O-acyltransferase activity [GO:0016411]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; glycerophospholipid phospholipase A1 activity [GO:0008970]; phosphatidylcholine lysophospholipase A1 activity [GO:0004622]; phospholipid binding [GO:0005543]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosome [GO:0005764]; membrane [GO:0016020]	GO:0004622; GO:0004623; GO:0005543; GO:0005576; GO:0005764; GO:0006644; GO:0006650; GO:0006651; GO:0006658; GO:0006672; GO:0008270; GO:0008970; GO:0009062; GO:0016020; GO:0016411; GO:0016747; GO:0034638; GO:0046338; GO:0046470; GO:0046471; GO:0070062
GN005369	GN005369.1	O57415	27.8	1663	1887	1615	2.36e-75	282	RREB1_CHICK	Ras-responsive element-binding protein 1 (RREB-1)	Gallus gallus (Chicken)	negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of developmental process [GO:0051094]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0001228; GO:0005634; GO:0006357; GO:0051094
GN005370	GN005370.1	Q02369	43.8	89	129	179	2.98e-10	58.2	NDUB9_BOVIN	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (CI-B22) (NADH-ubiquinone oxidoreductase B22 subunit)	Bos taurus (Bovine)	mitochondrial electron transport, NADH to ubiquinone [GO:0006120]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271]	GO:0005739; GO:0005743; GO:0006120; GO:0045271
GN005371	GN005371.1	Q6IQ73	65.9	223	223	224	7.64e-87	259	CHM4C_DANRE	Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint signaling [GO:0044878]; negative regulation of cytokinesis [GO:0032466]; nuclear membrane reassembly [GO:0031468]		cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; late endosome membrane [GO:0031902]; nuclear envelope [GO:0005635]	GO:0000815; GO:0005635; GO:0005829; GO:0009898; GO:0031468; GO:0031902; GO:0032466; GO:0032511; GO:0044878; GO:0060271; GO:0061952
GN005372	GN005372.1	Q08024	67.1	146	226	187	4.80e-68	210	PEBB_MOUSE	Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)	Mus musculus (Mouse)	cell maturation [GO:0048469]; definitive hemopoiesis [GO:0060216]; lymphocyte differentiation [GO:0030098]; myeloid cell differentiation [GO:0030099]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein polyubiquitination [GO:0000209]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; transcription coactivator activity [GO:0003713]	core-binding factor complex [GO:0016513]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000122; GO:0000209; GO:0001503; GO:0001649; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0006357; GO:0016513; GO:0030098; GO:0030099; GO:0032991; GO:0043371; GO:0043378; GO:0045944; GO:0048469; GO:0060216
GN005373	GN005373.1	Q92620	61.7	1245	1236	1227	0.0	1387	PRP16_HUMAN	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38)	Homo sapiens (Human)	mRNA splicing, via spliceosome [GO:0000398]	3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0000398; GO:0003723; GO:0003724; GO:0005524; GO:0005634; GO:0005654; GO:0005681; GO:0016020; GO:0016887; GO:0034458; GO:0071006; GO:0071013
GN005374	GN005374.1	Q6GM59	27.3	407	511	460	1.40e-44	166	MOT12_XENLA	Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12)	Xenopus laevis (African clawed frog)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; transmembrane transporter activity [GO:0022857]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0022857; GO:0046449
GN005375	GN005375.1	A9C3P0	55.2	192	185	285	4.07e-60	191	MLEC_DANRE	Malectin	Danio rerio (Zebrafish) (Brachydanio rerio)		carbohydrate binding [GO:0030246]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0030246
GN005377	GN005377.1	Q66JG2	32.4	170	163	215	5.55e-22	90.9	CPTP_XENTR	Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1) (CPTP)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	ceramide 1-phosphate transport [GO:1902389]; ceramide transport [GO:0035627]; intermembrane lipid transfer [GO:0120009]; negative regulation of autophagy [GO:0010507]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]	ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; nuclear outer membrane [GO:0005640]; plasma membrane [GO:0005886]	GO:0005543; GO:0005640; GO:0005794; GO:0005829; GO:0005886; GO:0010008; GO:0010507; GO:0032691; GO:0035627; GO:0120009; GO:1900226; GO:1902387; GO:1902388; GO:1902389
GN005379	GN005379.1	O15375	26.5	155	141	505	1.14e-09	58.5	MOT6_HUMAN	Monocarboxylate transporter 6 (MCT 6) (Monocarboxylate transporter 5) (MCT 5) (Solute carrier family 16 member 5)	Homo sapiens (Human)	monocarboxylic acid transport [GO:0015718]	monocarboxylic acid transmembrane transporter activity [GO:0008028]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0008028; GO:0015718; GO:0016020; GO:0016323
GN005381	GN005381.1	P53988	24.9	341	455	484	5.93e-22	101	MOT2_MESAU	Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)	Mesocricetus auratus (Golden hamster)	lactate transmembrane transport [GO:0035873]; plasma membrane lactate transport [GO:0035879]; pyruvate transmembrane transport [GO:1901475]	identical protein binding [GO:0042802]; lactate transmembrane transporter activity [GO:0015129]; pyruvate transmembrane transporter activity [GO:0050833]; symporter activity [GO:0015293]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0015129; GO:0015293; GO:0016323; GO:0035873; GO:0035879; GO:0042802; GO:0050833; GO:1901475
GN005382	GN005382.1	Q91437	67.4	2261	2237	2242	0.0	3004	PYR1_SQUAC	Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]	Squalus acanthias (Spiny dogfish)	'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; L-citrulline biosynthetic process [GO:0019240]; L-glutamine metabolic process [GO:0006541]; UTP biosynthetic process [GO:0006228]	amino acid binding [GO:0016597]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; dihydroorotase activity [GO:0004151]; glutaminase activity [GO:0004359]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004070; GO:0004087; GO:0004088; GO:0004151; GO:0004359; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006207; GO:0006228; GO:0006541; GO:0008270; GO:0016597; GO:0019240; GO:0044205
GN005383	GN005383.1	O57337	55.5	155	321	290	9.16e-44	154	HES1_CHICK	Transcription factor HES-1 (C-HAIRY1) (Hairy and enhancer of split 1)	Gallus gallus (Chicken)	anterior/posterior pattern specification [GO:0009952]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of neurogenesis [GO:0050767]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0005634; GO:0009952; GO:0042803; GO:0045665; GO:0046982; GO:0050767
GN005384	GN005384.1	Q90VV1	42.0	281	274	277	8.53e-45	155	HES4B_XENLA	Transcription factor HES-4-B (Hairy and enhancer of split 4-B) (Protein hairy-2) (Xhairy2) (Protein hairy-2a) (Xhairy2b)	Xenopus laevis (African clawed frog)	anterior/posterior pattern specification [GO:0009952]; floor plate development [GO:0033504]; lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest formation [GO:0014029]; prechordal plate formation [GO:0021501]; regulation of neurogenesis [GO:0050767]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0002088; GO:0005634; GO:0009952; GO:0014029; GO:0021501; GO:0033504; GO:0043066; GO:0043565; GO:0045892; GO:0046982; GO:0048642; GO:0050767
GN005385	GN005385.1	Q7ZV00	34.5	203	206	293	7.68e-22	93.6	OTU6B_DANRE	Deubiquitinase OTUD6B (EC 3.4.19.12)	Danio rerio (Zebrafish) (Brachydanio rerio)	antiviral innate immune response [GO:0140374]; protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]		GO:0004843; GO:0016579; GO:0140374
GN005386	GN005386.1	Q6NYE7	28.8	219	219	271	9.87e-15	74.3	TM192_DANRE	Transmembrane protein 192	Danio rerio (Zebrafish) (Brachydanio rerio)			late endosome [GO:0005770]; lysosomal membrane [GO:0005765]	GO:0005765; GO:0005770
GN005387	GN005387.1	P97697	50.0	260	274	277	2.03e-85	259	IMPA1_RAT	Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1)	Rattus norvegicus (Rat)	inositol biosynthetic process [GO:0006021]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; signal transduction [GO:0007165]	fructose-1-phosphatase activity [GO:0103026]; glucose-1-phosphatase activity [GO:0008877]; glucose-6-phosphatase activity [GO:0004346]; glycerol-2-phosphatase activity [GO:0047954]; identical protein binding [GO:0042802]; inositol monophosphate 1-phosphatase activity [GO:0008934]; inositol monophosphate 3-phosphatase activity [GO:0052832]; inositol monophosphate 4-phosphatase activity [GO:0052833]; inositol monophosphate phosphatase activity [GO:0052834]; lithium ion binding [GO:0031403]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]	GO:0000287; GO:0004346; GO:0005737; GO:0006021; GO:0006661; GO:0006796; GO:0007165; GO:0008877; GO:0008934; GO:0030145; GO:0030424; GO:0031403; GO:0042802; GO:0042803; GO:0043025; GO:0046854; GO:0047954; GO:0052832; GO:0052833; GO:0052834; GO:0103026
GN005390	GN005390.1	P51810	25.6	246	365	404	9.16e-20	93.2	GP143_HUMAN	G protein-coupled receptor 143 (Ocular albinism type 1 protein)	Homo sapiens (Human)	eye pigment biosynthetic process [GO:0006726]; G protein-coupled receptor signaling pathway [GO:0007186]; melanosome localization [GO:0032400]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of melanosome organization [GO:1903056]; regulation of melanosome transport [GO:1902908]; signal transduction [GO:0007165]; visual perception [GO:0007601]	dopamine binding [GO:0035240]; G protein-coupled receptor activity [GO:0004930]; L-DOPA binding [GO:0072544]; L-DOPA receptor activity [GO:0035643]; L-tyrosine binding [GO:0072545]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004930; GO:0005737; GO:0005765; GO:0005794; GO:0005886; GO:0006726; GO:0007165; GO:0007186; GO:0007200; GO:0007601; GO:0016020; GO:0016324; GO:0032400; GO:0032402; GO:0032438; GO:0033162; GO:0035240; GO:0035643; GO:0042470; GO:0072544; GO:0072545; GO:1902908; GO:1903056
GN005391	GN005391.1	Q9Y2E6	36.5	595	573	619	2.57e-89	291	DTX4_HUMAN	E3 ubiquitin-protein ligase DTX4 (EC 2.3.2.27) (Protein deltex-4) (Deltex4) (RING finger protein 155) (RING-type E3 ubiquitin transferase DTX4)	Homo sapiens (Human)	negative regulation of innate immune response [GO:0045824]; Notch signaling pathway [GO:0007219]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of type I interferon production [GO:0032479]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0004842; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0007219; GO:0008270; GO:0010498; GO:0016567; GO:0032479; GO:0043161; GO:0045824; GO:0061630; GO:0070936
GN005392	GN005392.1	Q8VDN4	30.5	249	295	314	1.67e-14	75.9	CCD92_MOUSE	Coiled-coil domain-containing protein 92	Mus musculus (Mouse)	adipose tissue development [GO:0060612]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; energy homeostasis [GO:0097009]; fatty acid metabolic process [GO:0006631]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage migration [GO:1905517]; NLRP3 inflammasome complex assembly [GO:0044546]; response to insulin [GO:0032868]	identical protein binding [GO:0042802]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0001889; GO:0002248; GO:0005654; GO:0005737; GO:0005813; GO:0005814; GO:0006631; GO:0006954; GO:0032868; GO:0042802; GO:0044546; GO:0060612; GO:0097009; GO:1905517
GN005393	GN005393.1	A0QAB6	39.8	88	108	309	4.23e-09	55.5	Y574_MYCA1	Uncharacterized tRNA/rRNA methyltransferase MAV_0574 (EC 2.1.1.-)	Mycobacterium avium (strain 104)	RNA processing [GO:0006396]	RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173]	cytosol [GO:0005829]	GO:0003723; GO:0005829; GO:0006396; GO:0008173
GN005395	GN005395.1	Q99J25	34.8	135	218	320	1.23e-15	77.4	MRM1_MOUSE	rRNA methyltransferase 1, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1145)-2'-O)-methyltransferase) (16S rRNA [Gm1145] 2'-O-methyltransferase)	Mus musculus (Mouse)	rRNA modification [GO:0000154]; rRNA processing [GO:0006364]	RNA binding [GO:0003723]; rRNA (guanine) methyltransferase activity [GO:0016435]; rRNA (guanosine-2'-O-ribose)-methyltransferase activity [GO:0070039]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0000154; GO:0003723; GO:0005739; GO:0005759; GO:0006364; GO:0016435; GO:0070039
GN005396	GN005396.1	Q32NQ8	39.3	684	757	756	3.02e-122	387	RNF10_XENLA	E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10)	Xenopus laevis (African clawed frog)	negative regulation of Schwann cell proliferation [GO:0010626]; nonfunctional rRNA decay [GO:0070651]; positive regulation of myelination [GO:0031643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein monoubiquitination [GO:0006513]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	metal ion binding [GO:0046872]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]	GO:0000976; GO:0005634; GO:0005737; GO:0005829; GO:0006513; GO:0010626; GO:0022626; GO:0031643; GO:0032790; GO:0045944; GO:0046872; GO:0061630; GO:0070651; GO:1990116
GN005398	GN005398.1	Q7TSH2	52.7	1060	1092	1085	0.0	1077	KPBB_MOUSE	Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta)	Mus musculus (Mouse)	glucose homeostasis [GO:0042593]; glycogen catabolic process [GO:0005980]; positive regulation of glycogen catabolic process [GO:0045819]; protein phosphorylation [GO:0006468]	calmodulin binding [GO:0005516]	phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886]	GO:0005516; GO:0005886; GO:0005964; GO:0005980; GO:0006468; GO:0042593; GO:0045819
GN005399	GN005399.1	O09053	45.7	199	249	1401	2.64e-54	191	WRN_MOUSE	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Werner syndrome protein homolog) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Mus musculus (Mouse)	base-excision repair [GO:0006284]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; cellular senescence [GO:0090398]; determination of adult lifespan [GO:0008340]; DNA damage response [GO:0006974]; DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; mismatch repair [GO:0006298]; positive regulation of hydrolase activity [GO:0051345]; positive regulation of strand invasion [GO:0098530]; protein localization to nucleolus [GO:1902570]; regulation of apoptotic process [GO:0042981]; regulation of growth rate [GO:0040009]; replication fork processing [GO:0031297]; replicative senescence [GO:0090399]; response to oxidative stress [GO:0006979]; response to UV-C [GO:0010225]; telomere maintenance [GO:0000723]; telomeric D-loop disassembly [GO:0061820]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; 3'-flap-structured DNA binding [GO:0070337]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bubble DNA binding [GO:0000405]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; exonuclease activity [GO:0004527]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MutLalpha complex binding [GO:0032405]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]	centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000287; GO:0000400; GO:0000403; GO:0000405; GO:0000723; GO:0000731; GO:0000781; GO:0003677; GO:0003678; GO:0003682; GO:0004527; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005730; GO:0005737; GO:0005813; GO:0006259; GO:0006260; GO:0006284; GO:0006298; GO:0006302; GO:0006310; GO:0006974; GO:0006979; GO:0008340; GO:0008408; GO:0009267; GO:0009378; GO:0010225; GO:0016607; GO:0016887; GO:0030145; GO:0031297; GO:0032392; GO:0032405; GO:0040009; GO:0042803; GO:0042981; GO:0043138; GO:0044877; GO:0051345; GO:0051880; GO:0061749; GO:0061820; GO:0061821; GO:0061849; GO:0070337; GO:0071480; GO:0090398; GO:0090399; GO:0098530; GO:1902570; GO:1905773
GN005400	GN005400.1	Q96I34	40.1	322	681	528	4.62e-62	219	PP16A_HUMAN	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3)	Homo sapiens (Human)		enzyme inhibitor activity [GO:0004857]; myosin phosphatase regulator activity [GO:0017020]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004857; GO:0005737; GO:0005886; GO:0017020
GN005401	GN005401.1	Q8BH79	48.4	492	486	659	1.11e-152	452	ANO10_MOUSE	Anoctamin-10 (Transmembrane protein 16K)	Mus musculus (Mouse)	chloride transmembrane transport [GO:1902476]	calcium-activated cation channel activity [GO:0005227]; intracellularly calcium-gated chloride channel activity [GO:0005229]	cilium [GO:0005929]; plasma membrane [GO:0005886]	GO:0005227; GO:0005229; GO:0005886; GO:0005929; GO:1902476
GN005405	GN005405.1	Q20929	28.4	352	376	510	2.38e-30	124	DMSR1_CAEEL	G protein-coupled receptor dmsr-1 (Dromyosuppressin receptor related 1)	Caenorhabditis elegans	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of cellular response to heat [GO:1900034]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008188; GO:0008528; GO:0032809; GO:0045187; GO:1900034
GN005409	GN005409.1	Q90404	33.9	398	378	1328	7.35e-56	201	AGRIN_DIPOM	Agrin	Diplobatis ommata (Ocellated electric ray) (Discopyge ommata)		calcium ion binding [GO:0005509]	cell periphery [GO:0071944]; extracellular region [GO:0005576]	GO:0005509; GO:0005576; GO:0071944
GN005411	GN005411.1	P31696	31.9	386	1007	2081	1.83e-45	182	AGRIN_CHICK	Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]	Gallus gallus (Chicken)	actin cytoskeleton organization [GO:0030036]; brain development [GO:0007420]; chemical synaptic transmission [GO:0007268]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; neuromuscular junction development [GO:0007528]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic assembly at neuromuscular junction [GO:0045887]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor clustering [GO:0043113]; signal transduction [GO:0007165]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]	acetylcholine receptor regulator activity [GO:0030548]; calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; dystroglycan binding [GO:0002162]; extracellular matrix binding [GO:0050840]; glycosaminoglycan binding [GO:0005539]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; laminin binding [GO:0043236]; laminin-1 binding [GO:0043237]; sialic acid binding [GO:0033691]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	axon [GO:0030424]; basal part of cell [GO:0045178]; basement membrane [GO:0005604]; extracellular matrix [GO:0031012]; extracellular matrix of synaptic cleft [GO:0098965]; extracellular region [GO:0005576]; gel phase of basement membrane [GO:0140148]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; neuromuscular junction [GO:0031594]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0002162; GO:0005509; GO:0005539; GO:0005576; GO:0005604; GO:0005886; GO:0007010; GO:0007158; GO:0007165; GO:0007268; GO:0007399; GO:0007420; GO:0007528; GO:0008201; GO:0010977; GO:0030036; GO:0030297; GO:0030424; GO:0030548; GO:0031012; GO:0031594; GO:0033691; GO:0035374; GO:0038023; GO:0043113; GO:0043236; GO:0043237; GO:0043395; GO:0045121; GO:0045178; GO:0045202; GO:0045887; GO:0045944; GO:0046847; GO:0050840; GO:0071340; GO:0098684; GO:0098965; GO:0098978; GO:0140148
GN005412	GN005412.1	A2ASQ1	45.2	73	111	1950	5.56e-16	75.5	AGRIN_MOUSE	Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]	Mus musculus (Mouse)	cell surface receptor signaling pathway [GO:0007166]; chemical synaptic transmission [GO:0007268]; chondrocyte differentiation [GO:0002062]; circadian rhythm [GO:0007623]; enzyme-linked receptor protein signaling pathway [GO:0007167]; filopodium assembly [GO:0046847]; negative regulation of sodium ion export across plasma membrane [GO:1903277]; nervous system development [GO:0007399]; neuromuscular junction development [GO:0007528]; plasma membrane organization [GO:0007009]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein binding [GO:0032092]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; positive regulation of synaptic assembly at neuromuscular junction [GO:0045887]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; receptor clustering [GO:0043113]; regulation of axon guidance [GO:1902667]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of synapse organization [GO:0050807]; regulation of synaptic activity [GO:0060025]; signal transduction [GO:0007165]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse assembly [GO:0007416]	acetylcholine receptor regulator activity [GO:0030548]; ATPase inhibitor activity [GO:0042030]; BMP binding [GO:0036122]; calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; dystroglycan binding [GO:0002162]; heparan sulfate proteoglycan binding [GO:0043395]; receptor ligand activity [GO:0048018]; sialic acid binding [GO:0033691]; transforming growth factor beta binding [GO:0050431]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]; transmembrane transporter binding [GO:0044325]; transporter inhibitor activity [GO:0141110]	axonal growth cone [GO:0044295]; basement membrane [GO:0005604]; cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; gel phase of basement membrane [GO:0140148]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; synapse [GO:0045202]	GO:0002062; GO:0002162; GO:0005509; GO:0005576; GO:0005604; GO:0005796; GO:0005886; GO:0007009; GO:0007165; GO:0007166; GO:0007167; GO:0007268; GO:0007399; GO:0007416; GO:0007528; GO:0007623; GO:0009986; GO:0015031; GO:0030297; GO:0030548; GO:0031012; GO:0032092; GO:0033691; GO:0035022; GO:0035374; GO:0036122; GO:0042030; GO:0042383; GO:0043113; GO:0043395; GO:0043525; GO:0044295; GO:0044325; GO:0045202; GO:0045887; GO:0045944; GO:0046847; GO:0048018; GO:0050431; GO:0050807; GO:0051491; GO:0055117; GO:0060025; GO:0070507; GO:0071340; GO:0086036; GO:0098978; GO:0140148; GO:0141110; GO:1902667; GO:1903277; GO:1904395
GN005414	GN005414.1	A3KQ55	39.5	564	651	645	3.65e-100	322	MEPCE_DANRE	7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) (zBCDIN3)	Danio rerio (Zebrafish) (Brachydanio rerio)	positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; RNA methylation [GO:0001510]; snRNA metabolic process [GO:0016073]; snRNA modification [GO:0040031]	O-methyltransferase activity [GO:0008171]; RNA 5'-gamma-phosphate methyltransferase activity [GO:1990276]; RNA methyltransferase activity [GO:0008173]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; snRNA binding [GO:0017069]	nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0001510; GO:0005634; GO:0008171; GO:0008173; GO:0008757; GO:0016073; GO:0017069; GO:0040031; GO:1904871; GO:1905382; GO:1990276; GO:1990904
GN005415	GN005415.1	Q8R5F7	28.4	751	709	1025	1.42e-57	214	IFIH1_MOUSE	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Helicase with 2 CARD domains) (Helicard) (Interferon induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (RIG-I-like receptor 2) (RLR-2)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; mRNA transcription [GO:0009299]; negative regulation of viral genome replication [GO:0045071]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of tumor necrosis factor production [GO:0032760]; protein complex oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; response to virus [GO:0009615]; type I interferon-mediated signaling pathway [GO:0060337]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; protein domain specific binding [GO:0019904]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0003677; GO:0003723; GO:0003724; GO:0003725; GO:0003727; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0008270; GO:0009299; GO:0009615; GO:0016887; GO:0016925; GO:0019904; GO:0032727; GO:0032728; GO:0032755; GO:0032760; GO:0038187; GO:0039530; GO:0042802; GO:0043021; GO:0045071; GO:0045087; GO:0051259; GO:0051607; GO:0060337; GO:0060760; GO:0071360; GO:0098586; GO:0140374
GN005421	GN005421.1	P57768	45.9	257	486	344	7.08e-60	203	SNX16_HUMAN	Sorting nexin-16	Homo sapiens (Human)	early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; protein targeting to lysosome [GO:0006622]; receptor recycling [GO:0001881]	identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]	GO:0001881; GO:0005764; GO:0005769; GO:0005770; GO:0006622; GO:0008333; GO:0010008; GO:0031901; GO:0031902; GO:0035091; GO:0042802; GO:0045022
GN005423	GN005423.1	Q4FZX0	60.4	389	420	434	5.55e-166	476	DEN11_XENLA	DENN domain-containing protein 11 (DENND11) (Protein LCHN)	Xenopus laevis (African clawed frog)			cytoplasm [GO:0005737]	GO:0005737
GN005426	GN005426.1	Q9ES03	61.0	331	457	445	4.74e-126	376	TBX20_MOUSE	T-box transcription factor TBX20 (T-box protein 20)	Mus musculus (Mouse)	aortic valve development [GO:0003176]; aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; atrioventricular canal development [GO:0036302]; atrioventricular valve development [GO:0003171]; blood circulation [GO:0008015]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac chamber formation [GO:0003207]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum development [GO:0003279]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube development [GO:0035050]; embryonic heart tube elongation [GO:0036306]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; foramen ovale closure [GO:0035922]; heart looping [GO:0001947]; mesenchymal cell development [GO:0014031]; muscle contraction [GO:0006936]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle process [GO:0090068]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary valve formation [GO:0003193]; pulmonary vein morphogenesis [GO:0060577]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of transcription by RNA polymerase II [GO:0006357]; tricuspid valve development [GO:0003175]; visceral motor neuron differentiation [GO:0021524]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0001569; GO:0001708; GO:0001764; GO:0001947; GO:0003143; GO:0003148; GO:0003151; GO:0003171; GO:0003175; GO:0003176; GO:0003180; GO:0003193; GO:0003203; GO:0003207; GO:0003215; GO:0003272; GO:0003279; GO:0003344; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0006936; GO:0008015; GO:0008283; GO:0009953; GO:0010717; GO:0010718; GO:0014031; GO:0021524; GO:0030513; GO:0035050; GO:0035922; GO:0036302; GO:0036306; GO:0043065; GO:0045892; GO:0045893; GO:0045944; GO:0055008; GO:0060045; GO:0060392; GO:0060413; GO:0060577; GO:0061629; GO:0090068; GO:1990837
GN005427	GN005427.1	Q9ES03	57.3	337	422	445	2.98e-112	339	TBX20_MOUSE	T-box transcription factor TBX20 (T-box protein 20)	Mus musculus (Mouse)	aortic valve development [GO:0003176]; aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; atrioventricular canal development [GO:0036302]; atrioventricular valve development [GO:0003171]; blood circulation [GO:0008015]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac chamber formation [GO:0003207]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum development [GO:0003279]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube development [GO:0035050]; embryonic heart tube elongation [GO:0036306]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; foramen ovale closure [GO:0035922]; heart looping [GO:0001947]; mesenchymal cell development [GO:0014031]; muscle contraction [GO:0006936]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell cycle process [GO:0090068]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary valve formation [GO:0003193]; pulmonary vein morphogenesis [GO:0060577]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of transcription by RNA polymerase II [GO:0006357]; tricuspid valve development [GO:0003175]; visceral motor neuron differentiation [GO:0021524]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0001569; GO:0001708; GO:0001764; GO:0001947; GO:0003143; GO:0003148; GO:0003151; GO:0003171; GO:0003175; GO:0003176; GO:0003180; GO:0003193; GO:0003203; GO:0003207; GO:0003215; GO:0003272; GO:0003279; GO:0003344; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0006936; GO:0008015; GO:0008283; GO:0009953; GO:0010717; GO:0010718; GO:0014031; GO:0021524; GO:0030513; GO:0035050; GO:0035922; GO:0036302; GO:0036306; GO:0043065; GO:0045892; GO:0045893; GO:0045944; GO:0055008; GO:0060045; GO:0060392; GO:0060413; GO:0060577; GO:0061629; GO:0090068; GO:1990837
GN005428	GN005428.1	Q54YM7	47.5	59	398	161	8.29e-11	63.5	TM2D2_DICDI	TM2 domain-containing protein DDB_G0278163	Dictyostelium discoideum (Social amoeba)			membrane [GO:0016020]	GO:0016020
GN005433	GN005433.1	Q9H0J9	30.3	706	1117	701	4.15e-64	234	PAR12_HUMAN	Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1)	Homo sapiens (Human)	protein auto-ADP-ribosylation [GO:0070213]; transepithelial transport [GO:0070633]	metal ion binding [GO:0046872]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; RNA binding [GO:0003723]	cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]	GO:0003723; GO:0003950; GO:0005634; GO:0005802; GO:0010494; GO:0046872; GO:0070213; GO:0070633; GO:0140803; GO:0140806; GO:1990404
GN005438	GN005438.1	Q9H0W7	40.0	85	290	228	5.04e-09	58.9	THAP2_HUMAN	THAP domain-containing protein 2	Homo sapiens (Human)			nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730
GN005439	GN005439.1	Q9R141	33.1	417	521	553	1.59e-57	203	S22A4_RAT	Solute carrier family 22 member 4 (Organic cation/carnitine transporter 1) (Octn1)	Rattus norvegicus (Rat)	acetylcholine uptake [GO:0051630]; amino acid import across plasma membrane [GO:0089718]; carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879]; lactation [GO:0007595]; liver regeneration [GO:0097421]; quaternary ammonium group transport [GO:0015697]; response to exogenous dsRNA [GO:0043330]; response to lipopolysaccharide [GO:0032496]; response to vitamin D [GO:0033280]; sodium-independent organic anion transport [GO:0043252]; sulfur amino acid transport [GO:0000101]; triglyceride metabolic process [GO:0006641]	acetylcholine transmembrane transporter activity [GO:0005277]; amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]	GO:0000101; GO:0005277; GO:0005524; GO:0005739; GO:0006641; GO:0007595; GO:0009437; GO:0009925; GO:0015171; GO:0015199; GO:0015226; GO:0015651; GO:0015697; GO:0015879; GO:0016324; GO:0030165; GO:0031966; GO:0032496; GO:0033280; GO:0043025; GO:0043252; GO:0043330; GO:0051630; GO:0089718; GO:0097421
GN005440	GN005440.1	Q9DGB6	37.2	148	152	781	2.67e-28	112	TLR22_CHICK	Toll-like receptor 2 type-2	Gallus gallus (Chicken)	detection of bacterial lipoprotein [GO:0042494]; immune response [GO:0006955]; inflammatory response [GO:0006954]; toll-like receptor signaling pathway [GO:0002224]	signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497]	plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0002224; GO:0004888; GO:0005886; GO:0006954; GO:0006955; GO:0038023; GO:0042494; GO:0042497; GO:0043235
GN005442	GN005442.1	F6VAN0	32.7	346	551	656	2.29e-33	138	ATF6A_MOUSE	Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha]	Mus musculus (Mouse)	endoplasmic reticulum unfolded protein response [GO:0030968]; eye development [GO:0001654]; positive regulation of apoptotic process [GO:0043065]; positive regulation of ATF6-mediated unfolded protein response [GO:1903893]; positive regulation of autophagy [GO:0010508]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; visual perception [GO:0007601]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000139; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0001650; GO:0001654; GO:0003700; GO:0005634; GO:0005654; GO:0005730; GO:0005783; GO:0005789; GO:0005794; GO:0006357; GO:0007601; GO:0010508; GO:0016020; GO:0019899; GO:0030968; GO:0031625; GO:0034976; GO:0042802; GO:0043065; GO:0043565; GO:0045944; GO:0046982; GO:0090575; GO:1903893; GO:1990837
GN005443	GN005443.1	A3KNI7	44.3	79	131	344	3.97e-13	67.8	CCDB1_DANRE	Cyclin-D1-binding protein 1 homolog (Zebrafish homolog of Maid)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN005446	GN005446.1	P15989	32.1	187	196	3137	1.21e-18	86.7	CO6A3_CHICK	Collagen alpha-3(VI) chain	Gallus gallus (Chicken)		serine-type endopeptidase inhibitor activity [GO:0004867]	collagen type VI trimer [GO:0005589]	GO:0004867; GO:0005589
GN005447	GN005447.1	Q9D411	46.9	294	326	328	4.74e-89	272	TSSK4_MOUSE	Testis-specific serine/threonine-protein kinase 4 (TSK-4) (TSSK-4) (Testis-specific kinase 4) (EC 2.7.11.1)	Mus musculus (Mouse)	fertilization [GO:0009566]; flagellated sperm motility [GO:0030317]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]	GO:0000287; GO:0001669; GO:0004672; GO:0004674; GO:0005524; GO:0006468; GO:0007286; GO:0009566; GO:0030317; GO:0031514; GO:0036126; GO:0042802; GO:0042803; GO:0044877; GO:0106310
GN005448	GN005448.1	Q9BSE4	34.8	411	384	406	1.32e-49	175	HERP2_HUMAN	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	Homo sapiens (Human)	endoplasmic reticulum unfolded protein response [GO:0030968]; spermatogenesis [GO:0007283]		membrane [GO:0016020]	GO:0007283; GO:0016020; GO:0030968
GN005450	GN005450.1	A9CJC9	35.7	465	553	479	7.28e-78	256	PHRA_AGRFC	Deoxyribodipyrimidine photo-lyase (EC 4.1.99.3) (Cyclobutane pyrimidine dimer photolyase) (CPD photolyase) (DNA photolyase PhrA) (Photoreactivating enzyme PhrA)	Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))	photoreactive repair [GO:0000719]; response to light stimulus [GO:0009416]	deoxyribodipyrimidine photo-lyase activity [GO:0003904]; DNA binding [GO:0003677]; FAD binding [GO:0071949]		GO:0000719; GO:0003677; GO:0003904; GO:0009416; GO:0071949
GN005451	GN005451.1	Q8SWR3	27.7	318	359	435	1.78e-17	86.7	SPR_DROME	Sex peptide receptor	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of egg-laying behavior [GO:0046662]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008528; GO:0045434; GO:0046662
GN005455	GN005455.1	Q8SWR3	31.0	348	364	435	6.21e-32	127	SPR_DROME	Sex peptide receptor	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of egg-laying behavior [GO:0046662]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008528; GO:0045434; GO:0046662
GN005459	GN005459.1	Q16943	55.6	268	255	260	1.23e-72	225	VP33_APLCA	Vesicle-associated membrane protein/synaptobrevin-binding protein (VAP-33)	Aplysia californica (California sea hare)	endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum-plasma membrane tethering [GO:0061817]	FFAT motif binding [GO:0033149]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0005789; GO:0005886; GO:0033149; GO:0045202; GO:0061817; GO:0090158
GN005460	GN005460.1	Q9UJX4	34.6	758	784	755	8.67e-131	410	APC5_HUMAN	Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5)	Homo sapiens (Human)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	protein phosphatase binding [GO:0019903]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0005634; GO:0005654; GO:0005680; GO:0005819; GO:0005829; GO:0007346; GO:0019903; GO:0031145; GO:0045842; GO:0051445; GO:0070936; GO:0070979; GO:0141198
GN005461	GN005461.1	O55135	83.9	242	245	245	1.37e-144	407	IF6_MOUSE	Eukaryotic translation initiation factor 6 (eIF-6) (B4 integrin interactor) (CAB) (p27(BBP))	Mus musculus (Mouse)	assembly of large subunit precursor of preribosome [GO:1902626]; cytosolic ribosome assembly [GO:0042256]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of translation [GO:0045727]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of glycolytic process [GO:0006110]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to insulin [GO:0032868]; ribosomal subunit export from nucleus [GO:0000054]	ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; intermediate filament [GO:0005882]; lamin filament [GO:0005638]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]	GO:0000054; GO:0000460; GO:0000470; GO:0003743; GO:0005634; GO:0005638; GO:0005654; GO:0005730; GO:0005737; GO:0005882; GO:0006110; GO:0032868; GO:0035195; GO:0035278; GO:0042256; GO:0042304; GO:0043022; GO:0043023; GO:0045202; GO:0045652; GO:0045727; GO:1902626; GO:2000377
GN005462	GN005462.1	Q19673	39.5	296	829	693	2.84e-46	180	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN005463	GN005463.1	Q19673	36.1	302	857	693	6.99e-48	185	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN005466	GN005466.1	Q5XIG0	55.2	288	318	350	2.07e-101	304	NUDT9_RAT	ADP-ribose pyrophosphatase (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9)	Rattus norvegicus (Rat)	ADP catabolic process [GO:0046032]	ADP-ribose diphosphatase activity [GO:0047631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0005737; GO:0005739; GO:0005829; GO:0046032; GO:0047631
GN005468	GN005468.1	A2CEI6	55.6	54	68	1046	9.53e-14	67.0	PIWL2_DANRE	Piwi-like protein 2 (EC 3.1.26.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	gamete generation [GO:0007276]; germ-line stem cell population maintenance [GO:0030718]; meiotic cell cycle [GO:0051321]; negative regulation of SMAD protein signal transduction [GO:0060392]; piRNA processing [GO:0034587]; positive regulation of gene expression [GO:0010628]; regulatory ncRNA-mediated gene silencing [GO:0031047]; secondary piRNA processing [GO:0140965]; spermatogenesis [GO:0007283]; transposable element silencing by heterochromatin formation [GO:0141005]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]	piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P granule [GO:0043186]; PET complex [GO:1990923]; pi-body [GO:0071546]	GO:0004521; GO:0005634; GO:0005737; GO:0007276; GO:0007283; GO:0010628; GO:0030718; GO:0031047; GO:0034584; GO:0034587; GO:0043186; GO:0051321; GO:0060392; GO:0071546; GO:0140965; GO:0141005; GO:0141196; GO:1990923
GN005469	GN005469.1	Q8MJ08	37.1	205	361	492	1.86e-29	121	PE2R4_BOVIN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0007188; GO:0007189; GO:0007204; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN005470	GN005470.1	Q96J94	75.0	80	82	861	2.08e-40	143	PIWL1_HUMAN	Piwi-like protein 1 (EC 3.1.26.-)	Homo sapiens (Human)	piRNA processing [GO:0034587]; piRNA-mediated gene silencing by mRNA destabilization [GO:0140991]; primary piRNA processing [GO:0140990]; regulatory ncRNA-mediated gene silencing [GO:0031047]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006]	mRNA binding [GO:0003729]; mRNA cap binding complex binding [GO:0140262]; piRNA binding [GO:0034584]; protein kinase binding [GO:0019901]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; dense body [GO:0097433]; nucleus [GO:0005634]; P granule [GO:0043186]	GO:0003727; GO:0003729; GO:0004521; GO:0005634; GO:0005737; GO:0007283; GO:0007286; GO:0019901; GO:0031047; GO:0033391; GO:0034584; GO:0034587; GO:0035092; GO:0043186; GO:0097433; GO:0140262; GO:0140990; GO:0140991; GO:0141006
GN005471	GN005471.1	A2CEI6	57.6	99	107	1046	3.81e-34	127	PIWL2_DANRE	Piwi-like protein 2 (EC 3.1.26.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	gamete generation [GO:0007276]; germ-line stem cell population maintenance [GO:0030718]; meiotic cell cycle [GO:0051321]; negative regulation of SMAD protein signal transduction [GO:0060392]; piRNA processing [GO:0034587]; positive regulation of gene expression [GO:0010628]; regulatory ncRNA-mediated gene silencing [GO:0031047]; secondary piRNA processing [GO:0140965]; spermatogenesis [GO:0007283]; transposable element silencing by heterochromatin formation [GO:0141005]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]	piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P granule [GO:0043186]; PET complex [GO:1990923]; pi-body [GO:0071546]	GO:0004521; GO:0005634; GO:0005737; GO:0007276; GO:0007283; GO:0010628; GO:0030718; GO:0031047; GO:0034584; GO:0034587; GO:0043186; GO:0051321; GO:0060392; GO:0071546; GO:0140965; GO:0141005; GO:0141196; GO:1990923
GN005472	GN005472.1	Q8UVX0	45.8	142	172	858	1.35e-36	137	PIWL1_DANRE	Piwi-like protein 1 (EC 3.1.26.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	anatomical structure morphogenesis [GO:0009653]; gamete generation [GO:0007276]; germ cell development [GO:0007281]; piRNA processing [GO:0034587]; regulation of cytoplasmic translation [GO:2000765]; regulatory ncRNA-mediated gene silencing [GO:0031047]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006]	piRNA binding [GO:0034584]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; P granule [GO:0043186]	GO:0004521; GO:0005737; GO:0007276; GO:0007281; GO:0007283; GO:0007286; GO:0009653; GO:0031047; GO:0034584; GO:0034587; GO:0035092; GO:0043186; GO:0141006; GO:2000765
GN005473	GN005473.1	A6N7Y9	50.0	62	63	867	1.81e-15	71.6	PIWL1_CHICK	Piwi-like protein 1 (EC 3.1.26.-)	Gallus gallus (Chicken)	piRNA processing [GO:0034587]; piRNA-mediated gene silencing by mRNA destabilization [GO:0140991]; primary piRNA processing [GO:0140990]; regulation of cytoplasmic translation [GO:2000765]; regulatory ncRNA-mediated gene silencing [GO:0031047]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated heterochromatin formation [GO:0141006]	mRNA binding [GO:0003729]; mRNA cap binding complex binding [GO:0140262]; piRNA binding [GO:0034584]; protein kinase binding [GO:0019901]; RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; dense body [GO:0097433]; nucleus [GO:0005634]; P granule [GO:0043186]	GO:0003727; GO:0003729; GO:0004521; GO:0005634; GO:0005737; GO:0007283; GO:0007286; GO:0019901; GO:0031047; GO:0033391; GO:0034584; GO:0034587; GO:0035092; GO:0043186; GO:0097433; GO:0140262; GO:0140990; GO:0140991; GO:0141006; GO:2000765
GN005474	GN005474.1	P43114	31.1	318	381	488	1.66e-36	141	PE2R4_RAT	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Rattus norvegicus (Rat)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to glucose stimulus [GO:0071333]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nematode [GO:0009624]; response to progesterone [GO:0032570]; response to prostaglandin E [GO:0034695]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; response to xenobiotic stimulus [GO:0009410]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009410; GO:0009612; GO:0009624; GO:0010628; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032570; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060135; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0070555; GO:0071260; GO:0071333; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1902074; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1990785; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN005478	GN005478.1	Q0KHY3	26.7	873	1052	1454	4.62e-64	241	MESH_DROME	Protein mesh	Drosophila melanogaster (Fruit fly)	cell-matrix adhesion [GO:0007160]; smooth septate junction assembly [GO:0090528]		apicolateral plasma membrane [GO:0016327]; plasma membrane [GO:0005886]; smooth septate junction [GO:0005920]	GO:0005886; GO:0005920; GO:0007160; GO:0016327; GO:0090528
GN005486	GN005486.1	P78412	63.5	126	422	446	2.25e-38	147	IRX6_HUMAN	Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6)	Homo sapiens (Human)	cell development [GO:0048468]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0030182; GO:0048468
GN005490	GN005490.1	Q9VZW5	32.8	344	382	549	7.30e-47	171	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN005494	GN005494.1	A0A345BJN8	32.0	203	590	919	4.84e-24	110	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN005495	GN005495.1	Q95YD4	27.2	224	372	867	7.35e-16	82.8	KIN32_CAEEL	Inactive tyrosine-protein kinase kin-32	Caenorhabditis elegans	signal complex assembly [GO:0007172]	ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713]	focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	GO:0004713; GO:0005524; GO:0005886; GO:0005925; GO:0007172
GN005496	GN005496.1	Q95YD4	26.0	223	1502	867	5.78e-13	77.8	KIN32_CAEEL	Inactive tyrosine-protein kinase kin-32	Caenorhabditis elegans	signal complex assembly [GO:0007172]	ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713]	focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	GO:0004713; GO:0005524; GO:0005886; GO:0005925; GO:0007172
GN005497	GN005497.1	Q6ZUX7	29.8	121	156	228	1.19e-12	66.2	LHPL2_HUMAN	LHFPL tetraspan subfamily member 2 protein (Lipoma HMGIC fusion partner-like 2 protein)	Homo sapiens (Human)	development of primary female sexual characteristics [GO:0046545]; development of primary male sexual characteristics [GO:0046546]; positive regulation of fertilization [GO:1905516]		membrane [GO:0016020]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	GO:0005886; GO:0016020; GO:0031092; GO:0046545; GO:0046546; GO:1905516
GN005501	GN005501.1	Q8C1B2	31.4	440	949	657	8.65e-46	179	PARPT_MOUSE	Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (TCDD-inducible poly [ADP-ribose] polymerase)	Mus musculus (Mouse)	androgen metabolic process [GO:0008209]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; female gonad development [GO:0008585]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; negative regulation of gene expression [GO:0010629]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of protein catabolic process [GO:0045732]; post-embryonic development [GO:0009791]; protein auto-ADP-ribosylation [GO:0070213]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745]; vasculogenesis [GO:0001570]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; metal ion binding [GO:0046872]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]	nucleus [GO:0005634]	GO:0000987; GO:0001570; GO:0001822; GO:0003950; GO:0005634; GO:0008209; GO:0008210; GO:0008585; GO:0009791; GO:0010629; GO:0030097; GO:0045732; GO:0046872; GO:0048008; GO:0048705; GO:0048745; GO:0060021; GO:0060325; GO:0070213; GO:0140803; GO:0140806; GO:0140807; GO:1904612; GO:1990404
GN005503	GN005503.1	A8Y1P7	44.7	235	337	384	3.00e-66	216	BRE4_CAEBR	Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.244) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)	Caenorhabditis briggsae	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; positive regulation of Notch signaling pathway [GO:0045747]; response to toxic substance [GO:0009636]	N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0005794; GO:0005975; GO:0006688; GO:0009101; GO:0009636; GO:0016020; GO:0033842; GO:0045747
GN005508	GN005508.1	Q08AW4	44.4	239	1002	748	6.40e-65	237	PKHM3_XENLA	Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3)	Xenopus laevis (African clawed frog)	myoblast differentiation [GO:0045445]		cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	GO:0005737; GO:0005794; GO:0005886; GO:0045445
GN005509	GN005509.1	Q3ZBV2	65.8	421	594	478	2.94e-199	569	DD19A_BOVIN	ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DEAD box protein 19A)	Bos taurus (Bovine)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleoplasm [GO:0005654]	GO:0003676; GO:0003724; GO:0005524; GO:0005654; GO:0005737; GO:0010494; GO:0016887
GN005511	GN005511.1	Q8EUM4	46.0	87	100	388	6.14e-11	60.5	DNAJ_MALP2	Chaperone protein DnaJ	Malacoplasma penetrans (strain HF-2) (Mycoplasma penetrans)	protein refolding [GO:0042026]; response to heat [GO:0009408]	ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005524; GO:0005737; GO:0008270; GO:0009408; GO:0031072; GO:0042026
GN005513	GN005513.1	Q4KKZ1	44.6	92	152	196	8.60e-20	84.3	CF107_MOUSE	Cilia- and flagella-associated protein 107	Mus musculus (Mouse)	flagellated sperm motility [GO:0030317]		axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; sperm flagellum [GO:0036126]	GO:0005879; GO:0030317; GO:0036126; GO:0160111
GN005534	GN005534.1	Q00341	56.1	1255	1247	1268	0.0	1328	VIGLN_HUMAN	Vigilin (High density lipoprotein-binding protein) (HDL-binding protein)	Homo sapiens (Human)	cholesterol metabolic process [GO:0008203]	cadherin binding [GO:0045296]; lipid binding [GO:0008289]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]	GO:0003723; GO:0003729; GO:0005783; GO:0005789; GO:0005886; GO:0008203; GO:0008289; GO:0016604; GO:0045296
GN005535	GN005535.1	Q9ESH5	35.9	128	210	211	1.48e-29	112	WFDC1_MOUSE	WAP four-disulfide core domain protein 1 (Prostate stromal protein ps20) (ps20 growth inhibitor)	Mus musculus (Mouse)	negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of inflammatory response [GO:0050728]; negative regulation of wound healing [GO:0061045]; regulation of cell growth [GO:0001558]	peptidase inhibitor activity [GO:0030414]	extracellular region [GO:0005576]	GO:0001558; GO:0005576; GO:0030414; GO:0050680; GO:0050728; GO:0061045
GN005540	GN005540.1	O88630	62.1	145	139	250	1.48e-52	169	GOSR1_MOUSE	Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28)	Mus musculus (Mouse)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; inter-Golgi cisterna vesicle-mediated transport [GO:0048219]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion [GO:0006906]	SNAP receptor activity [GO:0005484]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; SNARE complex [GO:0031201]	GO:0000139; GO:0005484; GO:0005794; GO:0005797; GO:0005801; GO:0005829; GO:0006888; GO:0006906; GO:0031201; GO:0042147; GO:0048219
GN005541	GN005541.1	A1K5T6	42.2	512	572	519	5.44e-127	385	SELO_AZOSB	Protein nucleotidyltransferase YdiU (EC 2.7.7.-) (Protein adenylyltransferase YdiU) (EC 2.7.7.108) (Protein uridylyltransferase YdiU) (EC 2.7.7.-)	Azoarcus sp. (strain BH72)		AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]		GO:0000287; GO:0005524; GO:0030145; GO:0070733
GN005542	GN005542.1	F1RKB1	48.8	86	93	467	2.03e-14	70.1	DRC10_PIG	Dynein regulatory complex subunit 10 (IQ domain-containing protein D)	Sus scrofa (Pig)			ciliary basal body [GO:0036064]	GO:0036064
GN005543	GN005543.1	Q4R8Y5	28.9	342	393	426	1.95e-32	129	DRC10_MACFA	Dynein regulatory complex subunit 10 (IQ domain-containing protein D)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)			ciliary basal body [GO:0036064]	GO:0036064
GN005544	GN005544.1	Q32KY6	59.2	125	173	169	1.44e-44	147	DCTP1_BOVIN	dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1)	Bos taurus (Bovine)	dCTP catabolic process [GO:0006253]; DNA protection [GO:0042262]; nucleoside triphosphate catabolic process [GO:0009143]	dCTP diphosphatase activity [GO:0047840]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleoside triphosphate diphosphatase activity [GO:0047429]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0000287; GO:0005634; GO:0005739; GO:0005829; GO:0006253; GO:0009143; GO:0042262; GO:0042802; GO:0047429; GO:0047840
GN005545	GN005545.1	Q32KY6	56.2	121	163	169	3.75e-42	141	DCTP1_BOVIN	dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1)	Bos taurus (Bovine)	dCTP catabolic process [GO:0006253]; DNA protection [GO:0042262]; nucleoside triphosphate catabolic process [GO:0009143]	dCTP diphosphatase activity [GO:0047840]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleoside triphosphate diphosphatase activity [GO:0047429]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0000287; GO:0005634; GO:0005739; GO:0005829; GO:0006253; GO:0009143; GO:0042262; GO:0042802; GO:0047429; GO:0047840
GN005546	GN005546.1	Q865F7	29.4	136	143	133	1.67e-12	63.5	FABPH_MYOLU	Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP)	Myotis lucifugus (Little brown bat)		lipid binding [GO:0008289]	cytoplasm [GO:0005737]	GO:0005737; GO:0008289
GN005551	GN005551.1	A2BFP5	47.7	888	929	899	9.55e-271	780	S12A9_DANRE	Solute carrier family 12 member 9	Danio rerio (Zebrafish) (Brachydanio rerio)	potassium ion transmembrane transport [GO:0071805]	chloride:monoatomic cation symporter activity [GO:0015377]	apical plasma membrane [GO:0016324]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	GO:0005765; GO:0005886; GO:0015377; GO:0016324; GO:0071805
GN005552	GN005552.1	P55937	32.3	130	1606	1487	1.75e-10	70.1	GOGA3_MOUSE	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2)	Mus musculus (Mouse)			cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0000139; GO:0005654; GO:0005730; GO:0005793; GO:0005794; GO:0005829; GO:0032580
GN005553	GN005553.1	Q68EQ9	63.6	368	413	406	3.98e-167	477	VMP1_XENTR	Vacuole membrane protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	lipoprotein transport [GO:0042953]	phospholipid scramblase activity [GO:0017128]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]	GO:0005774; GO:0005783; GO:0005789; GO:0005886; GO:0017128; GO:0033116; GO:0042953
GN005554	GN005554.1	Q9UPW0	34.4	520	422	622	5.50e-73	243	FOXJ3_HUMAN	Forkhead box protein J3	Homo sapiens (Human)	male meiosis I [GO:0007141]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0006357; GO:0007141; GO:0007283; GO:0043565; GO:0045944; GO:1990837
GN005562	GN005562.1	P46436	60.5	76	96	206	4.59e-26	98.6	GST1_ASCSU	Glutathione S-transferase 1 (EC 2.5.1.18) (GST class-sigma)	Ascaris suum (Pig roundworm) (Ascaris lumbricoides)	cellular oxidant detoxification [GO:0098869]; glutathione metabolic process [GO:0006749]	glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]	brush border [GO:0005903]; cytoplasm [GO:0005737]	GO:0004364; GO:0004602; GO:0005737; GO:0005903; GO:0006749; GO:0098869
GN005563	GN005563.1	P18426	34.1	91	99	205	2.32e-10	57.8	SCR11_NOTSL	S-crystallin SL11 (Major lens polypeptide)	Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei)	glutathione metabolic process [GO:0006749]	glutathione transferase activity [GO:0004364]		GO:0004364; GO:0006749
GN005570	GN005570.1	Q09225	25.6	726	812	822	2.20e-63	231	NRF6_CAEEL	Nose resistant to fluoxetine protein 6 (Protein nrf-6)	Caenorhabditis elegans		acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]	membrane [GO:0016020]	GO:0016020; GO:0016747
GN005573	GN005573.1	Q86YT5	43.2	597	637	568	3.51e-144	433	S13A5_HUMAN	Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5)	Homo sapiens (Human)	alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; citrate transport [GO:0015746]; fumarate transport [GO:0015741]; oxaloacetate transport [GO:0015729]; succinate transport [GO:0015744]; transmembrane transport [GO:0055085]	citrate transmembrane transporter activity [GO:0015137]; identical protein binding [GO:0042802]; organic acid:sodium symporter activity [GO:0005343]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]	plasma membrane [GO:0005886]	GO:0005343; GO:0005886; GO:0015137; GO:0015141; GO:0015729; GO:0015741; GO:0015742; GO:0015744; GO:0015746; GO:0017153; GO:0042802; GO:0055085; GO:0071285
GN005574	GN005574.1	Q2PGG3	45.5	264	279	331	3.98e-70	222	SRR_ARATH	Serine racemase (AtSR) (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17)	Arabidopsis thaliana (Mouse-ear cress)	D-serine biosynthetic process [GO:0070179]; L-serine metabolic process [GO:0006563]	ATP binding [GO:0005524]; D-serine ammonia-lyase activity [GO:0008721]; L-serine ammonia-lyase activity [GO:0003941]; magnesium ion binding [GO:0000287]; pyridoxal phosphate binding [GO:0030170]; serine racemase activity [GO:0030378]	chloroplast [GO:0009507]	GO:0000287; GO:0003941; GO:0005524; GO:0006563; GO:0008721; GO:0009507; GO:0030170; GO:0030378; GO:0070179
GN005575	GN005575.1	Q80TL0	45.2	115	524	749	7.25e-22	103	PPM1E_MOUSE	Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA)	Mus musculus (Mouse)	cellular response to lipopolysaccharide [GO:0071222]; cellular response to xenobiotic stimulus [GO:0071466]; negative regulation of protein kinase activity [GO:0006469]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of stress fiber assembly [GO:0051496]; protein dephosphorylation [GO:0006470]	cation binding [GO:0043169]; protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0004722; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006469; GO:0006470; GO:0032991; GO:0035970; GO:0043169; GO:0051496; GO:0071222; GO:0071466
GN005576	GN005576.1	P49593	43.6	296	341	454	1.39e-73	237	PPM1F_HUMAN	Protein phosphatase 1F (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (Protein fem-2 homolog) (hFem-2)	Homo sapiens (Human)	cellular response to xenobiotic stimulus [GO:0071466]; intracellular signal transduction [GO:0035556]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein transport [GO:0051224]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of growth [GO:0045927]; positive regulation of stress fiber assembly [GO:0051496]; regulation of protein localization [GO:0032880]	calmodulin-dependent protein phosphatase activity [GO:0033192]; cation binding [GO:0043169]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	GO:0004722; GO:0005634; GO:0005829; GO:0008138; GO:0010628; GO:0010634; GO:0010811; GO:0030335; GO:0032880; GO:0032991; GO:0033192; GO:0035556; GO:0043169; GO:0045892; GO:0045927; GO:0048471; GO:0050921; GO:0051224; GO:0051496; GO:0051894; GO:0071466; GO:2000048
GN005577	GN005577.1	P14003	50.8	61	318	337	6.84e-11	65.9	HAIR_DROME	Protein hairy	Drosophila melanogaster (Fruit fly)	anterior/posterior pattern specification [GO:0009952]; cell morphogenesis [GO:0000902]; membrane organization [GO:0061024]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; open tracheal system development [GO:0007424]; periodic partitioning by pair rule gene [GO:0007366]; posterior head segmentation [GO:0035289]; regulation of neurogenesis [GO:0050767]; response to hypoxia [GO:0001666]; salivary gland morphogenesis [GO:0007435]; trunk segmentation [GO:0035290]; tube morphogenesis [GO:0035239]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]	nucleus [GO:0005634]	GO:0000122; GO:0000902; GO:0000978; GO:0000981; GO:0001222; GO:0001227; GO:0001666; GO:0003677; GO:0005634; GO:0007366; GO:0007399; GO:0007424; GO:0007435; GO:0009952; GO:0035239; GO:0035289; GO:0035290; GO:0045892; GO:0046983; GO:0050767; GO:0061024; GO:0070888
GN005586	GN005586.1	Q5ZIJ9	37.6	901	880	954	7.64e-110	363	MIB2_CHICK	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (RING-type E3 ubiquitin transferase MIB2)	Gallus gallus (Chicken)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN005587	GN005587.1	Q8C206	29.5	329	345	330	2.58e-33	129	GP157_MOUSE	G protein-coupled receptor 157	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; radial glial cell differentiation [GO:0060019]	G protein-coupled receptor activity [GO:0004930]	ciliary membrane [GO:0060170]	GO:0004930; GO:0007166; GO:0007189; GO:0007200; GO:0048512; GO:0060019; GO:0060170
GN005588	GN005588.1	Q8C206	29.6	311	352	330	7.63e-36	135	GP157_MOUSE	G protein-coupled receptor 157	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; radial glial cell differentiation [GO:0060019]	G protein-coupled receptor activity [GO:0004930]	ciliary membrane [GO:0060170]	GO:0004930; GO:0007166; GO:0007189; GO:0007200; GO:0048512; GO:0060019; GO:0060170
GN005589	GN005589.1	Q8C206	28.6	280	340	330	2.15e-15	79.3	GP157_MOUSE	G protein-coupled receptor 157	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; radial glial cell differentiation [GO:0060019]	G protein-coupled receptor activity [GO:0004930]	ciliary membrane [GO:0060170]	GO:0004930; GO:0007166; GO:0007189; GO:0007200; GO:0048512; GO:0060019; GO:0060170
GN005594	GN005594.1	Q9Z2A7	57.6	432	481	498	4.68e-179	514	DGAT1_MOUSE	Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase)	Mus musculus (Mouse)	diacylglycerol metabolic process [GO:0046339]; fatty acid homeostasis [GO:0055089]; glycerolipid metabolic process [GO:0046486]; insulin secretion [GO:0030073]; lipid storage [GO:0019915]; lipid transport [GO:0006869]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; monoacylglycerol biosynthetic process [GO:0006640]; poly-hydroxybutyrate biosynthetic process [GO:0042619]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of eating behavior [GO:1903998]; regulation of intestinal lipid absorption [GO:1904729]; regulation of vitamin A metabolic process [GO:1901738]; retinoid metabolic process [GO:0001523]; triglyceride biosynthetic process [GO:0019432]; very-low-density lipoprotein particle assembly [GO:0034379]	2-acylglycerol O-acyltransferase activity [GO:0003846]; acyltransferase activity [GO:0016746]; diacylglycerol binding [GO:0019992]; diacylglycerol O-acyltransferase activity [GO:0004144]; fatty acid binding [GO:0005504]; identical protein binding [GO:0042802]; long-chain-alcohol O-fatty-acyltransferase activity [GO:0047196]; retinol O-fatty-acyltransferase activity [GO:0050252]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0001523; GO:0003846; GO:0004144; GO:0005504; GO:0005789; GO:0006640; GO:0006869; GO:0010867; GO:0016020; GO:0016746; GO:0019432; GO:0019915; GO:0019992; GO:0030073; GO:0034379; GO:0035336; GO:0042619; GO:0042802; GO:0046321; GO:0046339; GO:0046486; GO:0047196; GO:0050252; GO:0055089; GO:1901738; GO:1903998; GO:1904729; GO:2000491
GN005595	GN005595.1	Q2T9Q1	50.8	358	395	403	7.73e-114	341	TBC20_BOVIN	TBC1 domain family member 20	Bos taurus (Bovine)	COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; host-mediated activation of viral genome replication [GO:0044829]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; virion assembly [GO:0019068]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]	GO:0000139; GO:0005096; GO:0005789; GO:0006888; GO:0007030; GO:0019068; GO:0031267; GO:0031965; GO:0044829; GO:0046726; GO:0090110; GO:1902953
GN005596	GN005596.1	Q9H6D7	32.1	336	369	363	1.83e-42	154	HAUS4_HUMAN	HAUS augmin-like complex subunit 4	Homo sapiens (Human)	centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]		centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]	GO:0005813; GO:0005829; GO:0007098; GO:0010968; GO:0051225; GO:0070652; GO:1990498
GN005597	GN005597.1	P83436	40.3	682	692	770	3.65e-162	488	COG7_HUMAN	Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7)	Homo sapiens (Human)	glycoprotein biosynthetic process [GO:0009101]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein localization to Golgi apparatus [GO:0034067]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]		COG complex [GO:0017119]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network membrane [GO:0032588]	GO:0000139; GO:0000301; GO:0005794; GO:0006886; GO:0006890; GO:0007030; GO:0009101; GO:0017119; GO:0032588; GO:0033365; GO:0034067; GO:0050821
GN005602	GN005602.1	Q24432	92.0	75	425	972	9.09e-36	143	OMB_DROME	Optomotor-blind protein (Lethal(1)optomotor-blind) (L(1)omb) (Protein bifid)	Drosophila melanogaster (Fruit fly)	cell fate specification [GO:0001708]; compound eye morphogenesis [GO:0001745]; developmental pigmentation [GO:0048066]; imaginal disc-derived wing morphogenesis [GO:0007476]; negative regulation of transcription by RNA polymerase II [GO:0000122]; organ growth [GO:0035265]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; wing disc anterior/posterior pattern formation [GO:0048100]; wing disc morphogenesis [GO:0007472]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000978; GO:0000981; GO:0001708; GO:0001745; GO:0003677; GO:0005634; GO:0006357; GO:0007472; GO:0007476; GO:0035265; GO:0045893; GO:0048066; GO:0048100
GN005603	GN005603.1	O73718	64.4	208	220	414	2.34e-82	254	TBX3_CHICK	T-box transcription factor TBX3 (T-box protein 3)	Gallus gallus (Chicken)	anterior/posterior axis specification, embryo [GO:0008595]; cell fate specification [GO:0001708]; cellular senescence [GO:0090398]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; female genitalia development [GO:0030540]; follicle-stimulating hormone secretion [GO:0046884]; luteinizing hormone secretion [GO:0032275]; male genitalia development [GO:0030539]; mesoderm morphogenesis [GO:0048332]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myoblast differentiation [GO:0045662]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001501; GO:0001708; GO:0005634; GO:0006357; GO:0008595; GO:0030539; GO:0030540; GO:0032275; GO:0035115; GO:0042733; GO:0043066; GO:0043565; GO:0045662; GO:0045787; GO:0045892; GO:0045893; GO:0046884; GO:0048332; GO:0090398
GN005605	GN005605.1	O73718	63.2	315	640	414	4.32e-124	376	TBX3_CHICK	T-box transcription factor TBX3 (T-box protein 3)	Gallus gallus (Chicken)	anterior/posterior axis specification, embryo [GO:0008595]; cell fate specification [GO:0001708]; cellular senescence [GO:0090398]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; female genitalia development [GO:0030540]; follicle-stimulating hormone secretion [GO:0046884]; luteinizing hormone secretion [GO:0032275]; male genitalia development [GO:0030539]; mesoderm morphogenesis [GO:0048332]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of myoblast differentiation [GO:0045662]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal system development [GO:0001501]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001501; GO:0001708; GO:0005634; GO:0006357; GO:0008595; GO:0030539; GO:0030540; GO:0032275; GO:0035115; GO:0042733; GO:0043066; GO:0043565; GO:0045662; GO:0045787; GO:0045892; GO:0045893; GO:0046884; GO:0048332; GO:0090398
GN005606	GN005606.1	Q9H6U6	45.5	888	869	928	2.51e-234	686	BCAS3_HUMAN	BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1)	Homo sapiens (Human)	autophagy [GO:0006914]; cell-cell signaling [GO:0007267]; cellular response to estrogen stimulus [GO:0071391]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin cytoskeleton organization [GO:0032956]; response to estrogen [GO:0043627]	acetyltransferase activator activity [GO:0010698]; beta-tubulin binding [GO:0048487]; chromatin binding [GO:0003682]; histone acetyltransferase binding [GO:0035035]; histone binding [GO:0042393]; nuclear receptor binding [GO:0016922]; phosphatidylinositol binding [GO:0035091]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; euchromatin [GO:0000791]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; phagophore assembly site [GO:0000407]	GO:0000407; GO:0000791; GO:0003682; GO:0005634; GO:0005737; GO:0005881; GO:0006914; GO:0007267; GO:0010595; GO:0010698; GO:0016922; GO:0031252; GO:0032956; GO:0035035; GO:0035091; GO:0042393; GO:0043085; GO:0043627; GO:0045111; GO:0045944; GO:0048487; GO:0071391
GN005615	GN005615.1	P82251	36.5	192	311	487	9.59e-28	115	BAT1_HUMAN	b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)	Homo sapiens (Human)	amino acid transmembrane transport [GO:0003333]; L-cystine transport [GO:0015811]; neutral amino acid transport [GO:0015804]; protein-containing complex assembly [GO:0065003]	antiporter activity [GO:0015297]; broad specificity neutral L-amino acid:basic L-amino acid antiporter activity [GO:0180009]; L-cystine transmembrane transporter activity [GO:0015184]; L-lysine:L-arginine antiporter activity [GO:0106439]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; protein heterodimerization activity [GO:0046982]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]	GO:0003333; GO:0005886; GO:0015175; GO:0015184; GO:0015297; GO:0015804; GO:0015811; GO:0016324; GO:0031526; GO:0042605; GO:0046982; GO:0065003; GO:0106439; GO:0180009; GO:1902495
GN005620	GN005620.1	Q7ZX96	54.8	820	821	820	6.76e-308	867	NUP93_XENLA	Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (An4a) (Nucleoporin Nup93)	Xenopus laevis (African clawed frog)	nuclear pore complex assembly [GO:0051292]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein import into nucleus [GO:0006606]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]	GO:0005643; GO:0005829; GO:0006606; GO:0016973; GO:0017056; GO:0031965; GO:0034399; GO:0051292
GN005621	GN005621.1	Q9NX74	49.1	444	506	493	2.09e-144	426	DUS2_HUMAN	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; tRNA dihydrouridine synthesis [GO:0002943]	double-stranded RNA binding [GO:0003725]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADPH binding [GO:0070402]; protein kinase inhibitor activity [GO:0004860]; tRNA binding [GO:0000049]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine20 synthase activity [GO:0102264]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]	GO:0000049; GO:0002943; GO:0003725; GO:0004860; GO:0005737; GO:0005739; GO:0005783; GO:0005829; GO:0010181; GO:0017150; GO:0050660; GO:0070402; GO:0102264; GO:0140374
GN005622	GN005622.1	Q9H490	54.3	173	177	435	1.84e-66	212	PIGU_HUMAN	GPI-anchor transamidase component PIGU (Cell division cycle protein 91-like 1) (Protein CDC91-like 1) (GPI transamidase component PIG-U) (Phosphatidylinositol glycan anchor biosynthesis class U protein)	Homo sapiens (Human)	attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; GPI anchored protein biosynthesis [GO:0180046]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	GPI anchor binding [GO:0034235]	endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005789; GO:0005886; GO:0006506; GO:0016020; GO:0016255; GO:0034235; GO:0042765; GO:0046425; GO:0180046
GN005623	GN005623.1	P51452	46.1	152	200	185	7.69e-42	142	DUS3_HUMAN	Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR)	Homo sapiens (Human)	cellular response to epidermal growth factor stimulus [GO:0071364]; dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of focal adhesion assembly [GO:0051893]	cytoskeletal protein binding [GO:0008092]; MAP kinase phosphatase activity [GO:0033549]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; receptor signaling protein tyrosine kinase inhibitor activity [GO:0030294]; receptor tyrosine kinase binding [GO:0030971]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001772; GO:0004722; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0008092; GO:0008138; GO:0016311; GO:0016791; GO:0019901; GO:0030294; GO:0030336; GO:0030971; GO:0033549; GO:0035335; GO:0042059; GO:0043409; GO:0045931; GO:0046329; GO:0050860; GO:0050868; GO:0050922; GO:0051893; GO:0070373; GO:0071364; GO:0120183; GO:1990782
GN005626	GN005626.1	Q9V477	40.8	201	591	1346	1.66e-34	143	TOLL8_DROME	Toll-like receptor Tollo (Toll-like receptor 8)	Drosophila melanogaster (Fruit fly)	axis elongation [GO:0003401]; convergent extension [GO:0060026]; peripheral nervous system neuron development [GO:0048935]; regulation of glycoprotein biosynthetic process [GO:0010559]; signal transduction [GO:0007165]	receptor ligand activity [GO:0048018]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0003401; GO:0005886; GO:0007165; GO:0010559; GO:0016324; GO:0048018; GO:0048935; GO:0060026
GN005628	GN005628.1	Q5JPI3	34.6	318	332	329	1.36e-50	174	CC038_HUMAN	Uncharacterized protein C3orf38	Homo sapiens (Human)	positive regulation of apoptotic process [GO:0043065]		nucleus [GO:0005634]	GO:0005634; GO:0043065
GN005632	GN005632.1	Q9I7F7	54.3	70	104	1337	3.97e-18	81.3	ACKL_DROME	Activated Cdc42 kinase-like (EC 2.7.10.2) (Tyrosine-protein kinase PR2)	Drosophila melanogaster (Fruit fly)	dorsal closure, amnioserosa morphology change [GO:0046664]; head involution [GO:0008258]; myosin filament assembly [GO:0031034]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]	plasma membrane [GO:0005886]	GO:0004713; GO:0004715; GO:0005524; GO:0005886; GO:0006468; GO:0008258; GO:0031034; GO:0046664
GN005640	GN005640.1	P31228	43.6	328	339	341	4.91e-90	276	OXDD_BOVIN	D-aspartate oxidase (DASOX) (DASPO) (DDO) (EC 1.4.3.1)	Bos taurus (Bovine)	aspartate metabolic process [GO:0006531]; D-amino acid catabolic process [GO:0019478]; nervous system process [GO:0050877]	D-aspartate oxidase activity [GO:0008445]; D-glutamate oxidase activity [GO:0047821]; FAD binding [GO:0071949]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]	GO:0005782; GO:0005829; GO:0006531; GO:0008445; GO:0019478; GO:0047821; GO:0050877; GO:0071949
GN005643	GN005643.1	O88554	66.7	60	66	559	2.13e-18	80.1	PARP2_MOUSE	Poly [ADP-ribose] polymerase 2 (PARP-2) (mPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-)	Mus musculus (Mouse)	base-excision repair [GO:0006284]; decidualization [GO:0046697]; DNA ADP-ribosylation [GO:0030592]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; extrinsic apoptotic signaling pathway [GO:0097191]; hippocampal neuron apoptotic process [GO:0110088]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromatin [GO:0071168]; protein poly-ADP-ribosylation [GO:0070212]; response to oxygen-glucose deprivation [GO:0090649]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-serine ADP-ribosyltransferase activity [GO:0140805]; nucleosome binding [GO:0031491]; poly-ADP-D-ribose binding [GO:0072572]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0003682; GO:0003684; GO:0003950; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005829; GO:0006281; GO:0006284; GO:0006974; GO:0030592; GO:0031491; GO:0046697; GO:0061051; GO:0070212; GO:0070213; GO:0071168; GO:0072572; GO:0090649; GO:0090734; GO:0097191; GO:0110088; GO:0140294; GO:0140805; GO:0140806; GO:0140807; GO:0140861; GO:0160004; GO:1990404
GN005644	GN005644.1	O88554	54.1	338	743	559	4.84e-115	361	PARP2_MOUSE	Poly [ADP-ribose] polymerase 2 (PARP-2) (mPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-)	Mus musculus (Mouse)	base-excision repair [GO:0006284]; decidualization [GO:0046697]; DNA ADP-ribosylation [GO:0030592]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; extrinsic apoptotic signaling pathway [GO:0097191]; hippocampal neuron apoptotic process [GO:0110088]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromatin [GO:0071168]; protein poly-ADP-ribosylation [GO:0070212]; response to oxygen-glucose deprivation [GO:0090649]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; NAD DNA ADP-ribosyltransferase activity [GO:0140294]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-serine ADP-ribosyltransferase activity [GO:0140805]; nucleosome binding [GO:0031491]; poly-ADP-D-ribose binding [GO:0072572]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0003682; GO:0003684; GO:0003950; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005829; GO:0006281; GO:0006284; GO:0006974; GO:0030592; GO:0031491; GO:0046697; GO:0061051; GO:0070212; GO:0070213; GO:0071168; GO:0072572; GO:0090649; GO:0090734; GO:0097191; GO:0110088; GO:0140294; GO:0140805; GO:0140806; GO:0140807; GO:0140861; GO:0160004; GO:1990404
GN005650	GN005650.1	Q20929	26.6	350	352	510	8.01e-22	99.8	DMSR1_CAEEL	G protein-coupled receptor dmsr-1 (Dromyosuppressin receptor related 1)	Caenorhabditis elegans	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of cellular response to heat [GO:1900034]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008188; GO:0008528; GO:0032809; GO:0045187; GO:1900034
GN005656	GN005656.1	P43004	29.4	330	316	574	1.02e-38	147	EAA2_HUMAN	Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)	Homo sapiens (Human)	amino acid transport [GO:0006865]; cellular response to cocaine [GO:0071314]; chemical synaptic transmission [GO:0007268]; D-aspartate import across plasma membrane [GO:0070779]; glutathione biosynthetic process [GO:0006750]; intracellular glutamate homeostasis [GO:0090461]; L-aspartate import across plasma membrane [GO:0140009]; L-aspartate transmembrane transport [GO:0070778]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; neurotransmitter reuptake [GO:0098810]; neurotransmitter transport [GO:0006836]; protein homotrimerization [GO:0070207]; transepithelial transport [GO:0070633]; transport across blood-brain barrier [GO:0150104]	glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-cysteine transmembrane transporter activity [GO:0033229]; L-glutamate transmembrane transporter activity [GO:0005313]; monoatomic anion transmembrane transporter activity [GO:0008509]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	astrocyte projection [GO:0097449]; axolemma [GO:0030673]; cell body [GO:0044297]; cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; membrane protein complex [GO:0098796]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; vesicle [GO:0031982]	GO:0005313; GO:0005314; GO:0005886; GO:0006750; GO:0006836; GO:0006865; GO:0007268; GO:0008509; GO:0009986; GO:0015175; GO:0015501; GO:0015813; GO:0016020; GO:0030673; GO:0031982; GO:0033229; GO:0042734; GO:0044297; GO:0044306; GO:0045121; GO:0070207; GO:0070633; GO:0070778; GO:0070779; GO:0071314; GO:0090461; GO:0097449; GO:0098712; GO:0098796; GO:0098810; GO:0098978; GO:0140009; GO:0150104
GN005657	GN005657.1	Q9YHZ6	45.4	293	302	567	1.23e-93	291	CDC45_XENLA	Cell division control protein 45 homolog	Xenopus laevis (African clawed frog)	DNA replication initiation [GO:0006270]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication preinitiation complex assembly [GO:1902977]	chromatin binding [GO:0003682]; DNA replication origin binding [GO:0003688]; single-stranded DNA binding [GO:0003697]	chromosome [GO:0005694]; CMG complex [GO:0071162]; DNA replication preinitiation complex [GO:0031261]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000727; GO:0003682; GO:0003688; GO:0003697; GO:0005634; GO:0005654; GO:0005694; GO:0006270; GO:0031261; GO:0071162; GO:1902977
GN005659	GN005659.1	Q92890	56.5	168	174	307	2.68e-51	169	UFD1_HUMAN	Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1)	Homo sapiens (Human)	cellular response to misfolded protein [GO:0071218]; ERAD pathway [GO:0036503]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; rescue of stalled cytosolic ribosome [GO:0072344]; retrograde protein transport, ER to cytosol [GO:0030970]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]; skeletal system development [GO:0001501]; ubiquitin-dependent protein catabolic process [GO:0006511]	cysteine-type deubiquitinase activity [GO:0004843]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; polyubiquitin modification-dependent protein binding [GO:0031593]	ATPase complex [GO:1904949]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RQC complex [GO:1990112]; UFD1-NPL4 complex [GO:0036501]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	GO:0001501; GO:0004843; GO:0005634; GO:0005654; GO:0005829; GO:0006511; GO:0030970; GO:0031593; GO:0032480; GO:0034098; GO:0036435; GO:0036501; GO:0036503; GO:0039536; GO:0043161; GO:0071218; GO:0072344; GO:1904949; GO:1990112; GO:1990116
GN005661	GN005661.1	O96017	59.2	184	200	543	1.51e-75	239	CHK2_HUMAN	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)	Homo sapiens (Human)	cellular response to stress [GO:0033554]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; double-strand break repair [GO:0006302]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic DNA damage checkpoint signaling [GO:0044773]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; mitotic spindle assembly [GO:0090307]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of DNA-templated transcription [GO:0045893]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of autophagosome assembly [GO:2000785]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein catabolic process [GO:0042176]; regulation of signal transduction by p53 class mediator [GO:1901796]; replicative senescence [GO:0090399]; response to oxidative stress [GO:0006979]; response to starvation [GO:0042594]; signal transduction in response to DNA damage [GO:0042770]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0000077; GO:0000086; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006355; GO:0006468; GO:0006974; GO:0006979; GO:0008630; GO:0016605; GO:0019901; GO:0030163; GO:0030330; GO:0031573; GO:0031625; GO:0033554; GO:0042176; GO:0042594; GO:0042770; GO:0042802; GO:0042803; GO:0044773; GO:0045893; GO:0046777; GO:0050821; GO:0090307; GO:0090399; GO:0106310; GO:1901796; GO:2000785; GO:2000786
GN005664	GN005664.1	P93159	25.5	521	1059	668	2.91e-35	147	ENG1_SOYBN	Glucan endo-1,3-beta-D-glucosidase (Endo-1,3-beta-glucanase) (EC 3.2.1.39) (Beta-glucan elicitor-binding protein) (GEBP) (Laminarinase)	Glycine max (Soybean) (Glycine hispida)	cell wall polysaccharide catabolic process [GO:0044347]; detection of symbiotic fungus [GO:0009603]	glucan endo-1,3-beta-D-glucosidase activity [GO:0042973]; polysaccharide binding [GO:0030247]	plant-type cell wall [GO:0009505]	GO:0009505; GO:0009603; GO:0030247; GO:0042973; GO:0044347
GN005667	GN005667.1	P99027	68.1	72	112	115	1.13e-26	98.2	RLA2_MOUSE	Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2)	Mus musculus (Mouse)	cytoplasmic translation [GO:0002181]; cytoplasmic translational elongation [GO:0002182]; negative regulation of myoblast fusion [GO:1901740]; spermatogenesis [GO:0007283]; striated muscle contraction [GO:0006941]; translation at postsynapse [GO:0140242]; translation at presynapse [GO:0140236]	iron ion binding [GO:0005506]; ribonucleoprotein complex binding [GO:0043021]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; postsynapse [GO:0098794]; presynapse [GO:0098793]; ribosome [GO:0005840]; synapse [GO:0045202]	GO:0002181; GO:0002182; GO:0003735; GO:0005506; GO:0005737; GO:0005829; GO:0005840; GO:0006941; GO:0007283; GO:0022625; GO:0043021; GO:0045202; GO:0098793; GO:0098794; GO:0140236; GO:0140242; GO:1901740
GN005668	GN005668.1	Q16RX1	65.4	133	139	141	1.53e-53	168	MED21_AEDAE	Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	regulation of transcription by RNA polymerase II [GO:0006357]	transcription coregulator activity [GO:0003712]	mediator complex [GO:0016592]	GO:0003712; GO:0006357; GO:0016592
GN005669	GN005669.1	Q68FD5	83.3	1680	1680	1675	0.0	2831	CLH1_MOUSE	Clathrin heavy chain 1	Mus musculus (Mouse)	amyloid-beta clearance by transcytosis [GO:0150093]; clathrin coat assembly [GO:0048268]; clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of protein localization to plasma membrane [GO:1903077]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of mitotic spindle organization [GO:0060236]; retrograde transport, endosome to Golgi [GO:0042147]; synaptic vesicle endocytosis [GO:0048488]; transferrin transport [GO:0033572]	ankyrin binding [GO:0030506]; clathrin light chain binding [GO:0032051]; disordered domain specific binding [GO:0097718]; double-stranded RNA binding [GO:0003725]; heat shock protein binding [GO:0031072]; low-density lipoprotein particle receptor binding [GO:0050750]; peptide binding [GO:0042277]; protein kinase binding [GO:0019901]; protein serine/threonine kinase binding [GO:0120283]; structural molecule activity [GO:0005198]; ubiquitin-specific protease binding [GO:1990381]	centriolar satellite [GO:0034451]; clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endosome [GO:0005768]; extrinsic component of synaptic vesicle membrane [GO:0098850]; glutamatergic synapse [GO:0098978]; lysosome [GO:0005764]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane coat [GO:0030117]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]; Myb complex [GO:0031523]; myelin sheath [GO:0043209]; photoreceptor ribbon synapse [GO:0098684]; postsynaptic endocytic zone [GO:0098843]; presynaptic endocytic zone membrane [GO:0098835]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sperm midpiece [GO:0097225]; spindle [GO:0005819]; T-tubule [GO:0030315]	GO:0000278; GO:0003725; GO:0005198; GO:0005739; GO:0005764; GO:0005768; GO:0005819; GO:0005829; GO:0005905; GO:0006886; GO:0006898; GO:0007030; GO:0016020; GO:0019901; GO:0030117; GO:0030118; GO:0030130; GO:0030132; GO:0030136; GO:0030315; GO:0030506; GO:0031072; GO:0031523; GO:0031623; GO:0032051; GO:0032991; GO:0033572; GO:0034451; GO:0042147; GO:0042277; GO:0042383; GO:0042470; GO:0043209; GO:0045334; GO:0048268; GO:0048488; GO:0050750; GO:0060236; GO:0071439; GO:0072318; GO:0072583; GO:0072686; GO:0090307; GO:0097225; GO:0097718; GO:0098684; GO:0098835; GO:0098843; GO:0098850; GO:0098978; GO:0120283; GO:0150093; GO:1900126; GO:1903077; GO:1990381; GO:1990498
GN005671	GN005671.1	P56839	89.0	291	325	295	9.86e-189	524	PEPM_MYTED	Phosphoenolpyruvate phosphomutase (PEP mutase) (PEP phosphomutase) (Phosphoenolpyruvate mutase) (EC 5.4.2.9)	Mytilus edulis (Blue mussel)	organic phosphonate biosynthetic process [GO:0032923]	phosphoenolpyruvate mutase activity [GO:0050188]		GO:0032923; GO:0050188
GN005672	GN005672.1	Q8CJ44	30.3	238	249	572	2.12e-22	99.0	S13A5_RAT	Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5)	Rattus norvegicus (Rat)	alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; citrate transport [GO:0015746]; fumarate transport [GO:0015741]; oxaloacetate transport [GO:0015729]; succinate transport [GO:0015744]; transmembrane transport [GO:0055085]; tricarboxylic acid transport [GO:0006842]	citrate transmembrane transporter activity [GO:0015137]; identical protein binding [GO:0042802]; organic acid:sodium symporter activity [GO:0005343]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]; tricarboxylic acid transmembrane transporter activity [GO:0015142]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005343; GO:0005886; GO:0006842; GO:0015137; GO:0015141; GO:0015142; GO:0015729; GO:0015741; GO:0015742; GO:0015744; GO:0015746; GO:0016323; GO:0017153; GO:0042802; GO:0055085; GO:0071285
GN005673	GN005673.1	Q9ES88	57.8	116	167	586	1.70e-35	132	S13A2_MOUSE	Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter)	Mus musculus (Mouse)	alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; fumarate transport [GO:0015741]; succinate transmembrane transport [GO:0071422]	alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; citrate transmembrane transporter activity [GO:0015137]; fumarate transmembrane transporter activity [GO:0015138]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0005886; GO:0015137; GO:0015138; GO:0015139; GO:0015141; GO:0015741; GO:0015742; GO:0016324; GO:0017153; GO:0071285; GO:0071422
GN005674	GN005674.1	M9PH32	24.1	328	744	1206	2.67e-19	97.1	MEI26_DROME	Protein meiotic P26	Drosophila melanogaster (Fruit fly)	protein ubiquitination [GO:0016567]	ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]	GO:0004842; GO:0005737; GO:0008270; GO:0016567; GO:0036464
GN005675	GN005675.1	O43586	30.2	281	419	416	2.38e-30	124	PPIP1_HUMAN	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)	Homo sapiens (Human)	cell adhesion [GO:0007155]; signal transduction [GO:0007165]	identical protein binding [GO:0042802]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931]	GO:0001931; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0007155; GO:0007165; GO:0016020; GO:0030027; GO:0032154; GO:0042802; GO:0048471
GN005676	GN005676.1	A6QPU5	51.9	597	588	651	8.72e-205	589	SYDM_BOVIN	Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)	Bos taurus (Bovine)	aspartyl-tRNA aminoacylation [GO:0006422]; mitochondrial asparaginyl-tRNA aminoacylation [GO:0070145]	aspartate-tRNA ligase activity [GO:0004815]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]	mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	GO:0003676; GO:0004815; GO:0005524; GO:0005739; GO:0005759; GO:0006422; GO:0031966; GO:0070145
GN005678	GN005678.1	Q6XV80	33.3	192	797	763	5.03e-26	118	NBN_XENLA	Nibrin (Nijmegen breakage syndrome protein 1 homolog) (xNBS1)	Xenopus laevis (African clawed frog)	DNA double-strand break processing [GO:0000729]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; isotype switching [GO:0045190]; metaphase chromosome alignment [GO:0051310]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to site of double-strand break [GO:1990166]; R-loop processing [GO:0062176]; regulation of fibroblast proliferation [GO:0048145]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]	chromatin-protein adaptor activity [GO:0140463]; damaged DNA binding [GO:0003684]; DNA-binding transcription factor binding [GO:0140297]; phosphorylation-dependent protein binding [GO:0140031]; protein serine/threonine kinase activator activity [GO:0043539]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; Mre11 complex [GO:0030870]; nuclear inclusion body [GO:0042405]; nucleus [GO:0005634]; PML body [GO:0016605]; site of double-strand break [GO:0035861]	GO:0000723; GO:0000724; GO:0000729; GO:0000781; GO:0003684; GO:0005634; GO:0005694; GO:0006302; GO:0007095; GO:0016605; GO:0030870; GO:0031848; GO:0035861; GO:0042405; GO:0043247; GO:0043539; GO:0045190; GO:0048145; GO:0051310; GO:0062176; GO:0110025; GO:0140031; GO:0140297; GO:0140463; GO:1990166
GN005684	GN005684.1	P05099	28.9	436	403	493	4.88e-43	160	MATN1_CHICK	Matrilin-1 (Cartilage matrix protein)	Gallus gallus (Chicken)		calcium ion binding [GO:0005509]	extracellular matrix [GO:0031012]	GO:0005509; GO:0031012
GN005685	GN005685.1	Q8C6K9	30.5	407	409	2265	2.45e-39	154	CO6A6_MOUSE	Collagen alpha-6(VI) chain	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]		collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005589; GO:0030198; GO:0031012
GN005686	GN005686.1	Q96EP1	38.9	445	541	664	5.44e-85	280	CHFR_HUMAN	E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196) (RING-type E3 ubiquitin transferase CHFR)	Homo sapiens (Human)	meiotic spindle checkpoint signaling [GO:0044779]; mitotic G2/M transition checkpoint [GO:0044818]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	nucleotide binding [GO:0000166]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	nucleus [GO:0005634]; PML body [GO:0016605]	GO:0000166; GO:0004842; GO:0005634; GO:0006511; GO:0016567; GO:0016605; GO:0044779; GO:0044818; GO:0061630
GN005687	GN005687.1	Q29486	50.6	466	469	524	1.64e-149	439	PPBT_FELCA	Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) (Phosphoamidase) (Phosphocreatine phosphatase) (EC 3.9.1.1)	Felis catus (Cat) (Felis silvestris catus)	bone mineralization [GO:0030282]; dephosphorylation [GO:0016311]; positive regulation of cold-induced thermogenesis [GO:0120162]	5'-nucleotidase activity [GO:0008253]; ADP phosphatase activity [GO:0043262]; alkaline phosphatase activity [GO:0004035]; ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; inorganic diphosphate phosphatase activity [GO:0004427]; phosphoamidase activity [GO:0050187]; phosphoethanolamine phosphatase activity [GO:0052732]; pyridoxal phosphatase activity [GO:0033883]; pyrophosphatase activity [GO:0016462]	mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	GO:0004035; GO:0004427; GO:0005509; GO:0005758; GO:0005886; GO:0008253; GO:0016311; GO:0016462; GO:0016887; GO:0030282; GO:0031966; GO:0033883; GO:0043262; GO:0050187; GO:0052732; GO:0120162
GN005690	GN005690.1	Q9I7F7	54.3	554	1554	1337	2.49e-170	552	ACKL_DROME	Activated Cdc42 kinase-like (EC 2.7.10.2) (Tyrosine-protein kinase PR2)	Drosophila melanogaster (Fruit fly)	dorsal closure, amnioserosa morphology change [GO:0046664]; head involution [GO:0008258]; myosin filament assembly [GO:0031034]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]	plasma membrane [GO:0005886]	GO:0004713; GO:0004715; GO:0005524; GO:0005886; GO:0006468; GO:0008258; GO:0031034; GO:0046664
GN005692	GN005692.1	Q07912	58.2	91	116	1038	2.51e-28	110	ACK1_HUMAN	Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)	Homo sapiens (Human)	cell surface receptor signaling pathway [GO:0007166]; phosphorylation [GO:0016310]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of clathrin-dependent endocytosis [GO:2000369]; small GTPase-mediated signal transduction [GO:0007264]	ATP binding [GO:0005524]; epidermal growth factor receptor binding [GO:0005154]; GTPase inhibitor activity [GO:0005095]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]	adherens junction [GO:0005912]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome [GO:0005768]; Grb2-EGFR complex [GO:0070436]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0004674; GO:0004712; GO:0004713; GO:0004715; GO:0005095; GO:0005154; GO:0005524; GO:0005634; GO:0005737; GO:0005768; GO:0005829; GO:0005886; GO:0005905; GO:0005912; GO:0007166; GO:0007264; GO:0016020; GO:0016310; GO:0030136; GO:0030659; GO:0031625; GO:0042802; GO:0048471; GO:0050699; GO:0050731; GO:0070436; GO:0097268; GO:0106310; GO:2000369
GN005693	GN005693.1	O54967	52.6	76	380	1055	6.64e-14	77.0	ACK1_MOUSE	Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2)	Mus musculus (Mouse)	phosphorylation [GO:0016310]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of clathrin-dependent endocytosis [GO:2000369]; signal transduction [GO:0007165]; spermatid development [GO:0007286]	ATP binding [GO:0005524]; epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]	adherens junction [GO:0005912]; axon [GO:0030424]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; dendrite [GO:0030425]; endosome [GO:0005768]; Grb2-EGFR complex [GO:0070436]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic cytosol [GO:0099524]; presynaptic cytosol [GO:0099523]	GO:0004674; GO:0004712; GO:0004713; GO:0004715; GO:0005154; GO:0005524; GO:0005634; GO:0005737; GO:0005768; GO:0005886; GO:0005905; GO:0005912; GO:0007165; GO:0007286; GO:0016310; GO:0030136; GO:0030424; GO:0030425; GO:0030426; GO:0030659; GO:0031625; GO:0042802; GO:0043025; GO:0050699; GO:0050731; GO:0070436; GO:0097268; GO:0099523; GO:0099524; GO:0106310; GO:2000369
GN005696	GN005696.1	P14943	59.0	105	109	532	2.42e-36	132	EST2_RABIT	Cocaine esterase (EC 3.1.1.84) (Liver carboxylesterase 2) (EC 3.1.1.1)	Oryctolagus cuniculus (Rabbit)		carboxylesterase activity [GO:0106435]	endoplasmic reticulum lumen [GO:0005788]	GO:0005788; GO:0106435
GN005698	GN005698.1	O15943	34.5	2898	2923	3097	0.0	1266	CADN_DROME	Neural-cadherin (Cadherin-N) (dN-cadherin)	Drosophila melanogaster (Fruit fly)	axon extension [GO:0048675]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; axonal fasciculation [GO:0007413]; calcium-dependent cell-cell adhesion [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell-cell adhesion [GO:0007156]; negative regulation of dendrite morphogenesis [GO:0050774]; ommatidial rotation [GO:0016318]; R7 cell development [GO:0045467]; R8 cell development [GO:0045463]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of dendrite morphogenesis [GO:0048814]; retinal ganglion cell axon guidance [GO:0031290]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005911; GO:0007156; GO:0007411; GO:0007412; GO:0007413; GO:0016020; GO:0016318; GO:0016339; GO:0030424; GO:0030425; GO:0031290; GO:0042803; GO:0044331; GO:0045296; GO:0045463; GO:0045467; GO:0048675; GO:0048814; GO:0048841; GO:0048846; GO:0050774; GO:0098609
GN005715	GN005715.1	Q9D305	39.8	88	204	217	7.12e-09	57.0	THAP2_MOUSE	THAP domain-containing protein 2	Mus musculus (Mouse)			nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730
GN005728	GN005728.1	Q5F364	51.8	886	973	1525	4.00e-293	860	MRP1_CHICK	Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter)	Gallus gallus (Chicken)	cyclic nucleotide transport [GO:0070729]; glutathione transmembrane transport [GO:0034775]; xenobiotic transport [GO:0042908]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; carboxylic acid transmembrane transporter activity [GO:0046943]; glutathione transmembrane transporter activity [GO:0034634]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005524; GO:0005886; GO:0008559; GO:0015431; GO:0016323; GO:0016887; GO:0034634; GO:0034775; GO:0042908; GO:0046943; GO:0070729
GN005730	GN005730.1	Q24JY1	72.9	118	172	156	3.51e-47	154	RL23A_BOVIN	Large ribosomal subunit protein uL23 (60S ribosomal protein L23a)	Bos taurus (Bovine)	translation [GO:0006412]	rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; TORC2 complex binding [GO:1904841]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]; nucleus [GO:0005634]	GO:0003735; GO:0005634; GO:0005737; GO:0006412; GO:0019843; GO:0022625; GO:1904841
GN005732	GN005732.1	O95755	52.5	80	97	267	3.52e-19	82.0	RAB36_HUMAN	Ras-related protein Rab-36 (EC 3.6.5.2)	Homo sapiens (Human)		G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0003924; GO:0003925; GO:0005525; GO:0005794
GN005733	GN005733.1	Q6DKJ4	55.7	97	115	435	4.20e-30	114	NXN_HUMAN	Nucleoredoxin (EC 1.8.1.8)	Homo sapiens (Human)	circulatory system development [GO:0072359]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055]	thioredoxin-disulfide reductase (NADPH) activity [GO:0004791]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004791; GO:0005634; GO:0005829; GO:0016055; GO:0030178; GO:0031397; GO:0072359
GN005734	GN005734.1	Q6DKJ4	48.2	110	113	435	2.02e-29	112	NXN_HUMAN	Nucleoredoxin (EC 1.8.1.8)	Homo sapiens (Human)	circulatory system development [GO:0072359]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055]	thioredoxin-disulfide reductase (NADPH) activity [GO:0004791]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004791; GO:0005634; GO:0005829; GO:0016055; GO:0030178; GO:0031397; GO:0072359
GN005740	GN005740.1	Q20929	27.9	355	409	510	2.35e-30	125	DMSR1_CAEEL	G protein-coupled receptor dmsr-1 (Dromyosuppressin receptor related 1)	Caenorhabditis elegans	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of cellular response to heat [GO:1900034]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008188; GO:0008528; GO:0032809; GO:0045187; GO:1900034
GN005745	GN005745.1	Q9DBM1	42.3	783	1006	930	7.55e-168	519	GPTC1_MOUSE	G patch domain-containing protein 1	Mus musculus (Mouse)	mRNA processing [GO:0006397]	nucleic acid binding [GO:0003676]	catalytic step 2 spliceosome [GO:0071013]	GO:0003676; GO:0006397; GO:0071013
GN005746	GN005746.1	A1L1R6	23.9	1140	1229	1365	1.13e-53	209	ZN423_DANRE	Zinc finger protein 423	Danio rerio (Zebrafish) (Brachydanio rerio)	negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0001228; GO:0005634; GO:0006357; GO:0045892
GN005747	GN005747.1	Q9Y2C9	26.9	398	398	796	8.18e-33	134	TLR6_HUMAN	Toll-like receptor 6 (CD antigen CD286)	Homo sapiens (Human)	activation of NF-kappaB-inducing kinase activity [GO:0007250]; antibacterial innate immune response [GO:0140367]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide metabolic process [GO:0046209]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macrophage activation [GO:0043032]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	amyloid-beta binding [GO:0001540]; diacyl lipopeptide binding [GO:0042498]; identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	GO:0001540; GO:0001774; GO:0002224; GO:0002755; GO:0004888; GO:0005102; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0007165; GO:0007250; GO:0010628; GO:0030670; GO:0031663; GO:0032717; GO:0032720; GO:0032731; GO:0032755; GO:0034136; GO:0035355; GO:0035663; GO:0035666; GO:0038023; GO:0038124; GO:0042496; GO:0042498; GO:0042742; GO:0042802; GO:0043032; GO:0043123; GO:0043235; GO:0043507; GO:0045087; GO:0045121; GO:0045429; GO:0046209; GO:0046982; GO:0050729; GO:0071723; GO:0071726; GO:0140052; GO:0140367; GO:1900017; GO:1900227; GO:1903428; GO:1904646; GO:2001238
GN005754	GN005754.1	Q86U38	24.7	576	583	636	2.80e-44	170	NOP9_HUMAN	Nucleolar protein 9	Homo sapiens (Human)	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; ribosomal small subunit export from nucleus [GO:0000056]	RNA binding [GO:0003723]	90S preribosome [GO:0030686]; preribosome, small subunit precursor [GO:0030688]	GO:0000056; GO:0000447; GO:0000472; GO:0000480; GO:0003723; GO:0030686; GO:0030688
GN005757	GN005757.1	Q8L397	48.6	70	226	369	8.65e-14	72.8	DNAJ_ACHLA	Chaperone protein DnaJ	Acholeplasma laidlawii	protein refolding [GO:0042026]; response to heat [GO:0009408]	ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005524; GO:0005737; GO:0008270; GO:0009408; GO:0031072; GO:0042026
GN005758	GN005758.1	Q9H0H0	47.8	719	763	1196	4.64e-208	623	INT2_HUMAN	Integrator complex subunit 2 (Int2)	Homo sapiens (Human)	regulation of transcription elongation by RNA polymerase II [GO:0034243]; RNA polymerase II transcription initiation surveillance [GO:0160240]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]		cytoplasm [GO:0005737]; INTAC complex [GO:0160232]; integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0016020; GO:0016180; GO:0031965; GO:0032039; GO:0034243; GO:0034472; GO:0160232; GO:0160240
GN005759	GN005759.1	Q9H0H0	62.0	92	96	1196	6.59e-32	120	INT2_HUMAN	Integrator complex subunit 2 (Int2)	Homo sapiens (Human)	regulation of transcription elongation by RNA polymerase II [GO:0034243]; RNA polymerase II transcription initiation surveillance [GO:0160240]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]		cytoplasm [GO:0005737]; INTAC complex [GO:0160232]; integrator complex [GO:0032039]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0016020; GO:0016180; GO:0031965; GO:0032039; GO:0034243; GO:0034472; GO:0160232; GO:0160240
GN005764	GN005764.1	D3YZI9	32.2	121	251	523	6.73e-09	59.3	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN005767	GN005767.1	Q8AXX2	73.5	34	165	460	1.16e-09	59.3	TBX1_DANRE	T-box transcription factor TBX1 (T-box protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cardiac muscle cell differentiation [GO:0055007]; cartilage morphogenesis [GO:0060536]; cell fate specification [GO:0001708]; chordate pharyngeal muscle development [GO:0043282]; ear development [GO:0043583]; ear morphogenesis [GO:0042471]; embryonic heart tube morphogenesis [GO:0003143]; embryonic viscerocranium morphogenesis [GO:0048703]; heart development [GO:0007507]; heart looping [GO:0001947]; neural crest cell development [GO:0014032]; neural crest cell migration [GO:0001755]; parathyroid gland development [GO:0060017]; pharyngeal system development [GO:0060037]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; regulation of transcription by RNA polymerase II [GO:0006357]; semicircular canal morphogenesis [GO:0048752]; soft palate development [GO:0060023]; thymus development [GO:0048538]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001708; GO:0001755; GO:0001947; GO:0003143; GO:0005634; GO:0006357; GO:0007507; GO:0014032; GO:0042471; GO:0042803; GO:0043282; GO:0043565; GO:0043583; GO:0045893; GO:0048538; GO:0048703; GO:0048752; GO:0055007; GO:0060017; GO:0060023; GO:0060037; GO:0060536; GO:0072513
GN005768	GN005768.1	O43435	79.5	151	150	398	1.60e-87	263	TBX1_HUMAN	T-box transcription factor TBX1 (T-box protein 1) (Testis-specific T-box protein)	Homo sapiens (Human)	angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; aorta morphogenesis [GO:0035909]; artery morphogenesis [GO:0048844]; blood vessel development [GO:0001568]; blood vessel morphogenesis [GO:0048514]; cell fate specification [GO:0001708]; cell population proliferation [GO:0008283]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to retinoic acid [GO:0071300]; cochlea morphogenesis [GO:0090103]; coronary artery morphogenesis [GO:0060982]; determination of left/right symmetry [GO:0007368]; ear morphogenesis [GO:0042471]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic viscerocranium morphogenesis [GO:0048703]; enamel mineralization [GO:0070166]; epithelial cell differentiation [GO:0030855]; face morphogenesis [GO:0060325]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; lymph vessel development [GO:0001945]; mesenchymal cell apoptotic process [GO:0097152]; mesoderm development [GO:0007498]; middle ear morphogenesis [GO:0042474]; muscle cell fate commitment [GO:0042693]; muscle organ development [GO:0007517]; muscle organ morphogenesis [GO:0048644]; muscle tissue morphogenesis [GO:0060415]; negative regulation of cell differentiation [GO:0045596]; negative regulation of mesenchymal cell apoptotic process [GO:2001054]; neural crest cell migration [GO:0001755]; odontogenesis of dentin-containing tooth [GO:0042475]; outer ear morphogenesis [GO:0042473]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; parathyroid gland development [GO:0060017]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of tongue muscle cell differentiation [GO:2001037]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of animal organ morphogenesis [GO:2000027]; regulation of transcription by RNA polymerase II [GO:0006357]; retinoic acid receptor signaling pathway [GO:0048384]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; soft palate development [GO:0060023]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; tongue morphogenesis [GO:0043587]; vagus nerve morphogenesis [GO:0021644]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001525; GO:0001568; GO:0001708; GO:0001755; GO:0001934; GO:0001945; GO:0002053; GO:0003007; GO:0003148; GO:0003151; GO:0003677; GO:0005634; GO:0006357; GO:0007368; GO:0007389; GO:0007498; GO:0007507; GO:0007517; GO:0007605; GO:0008283; GO:0008284; GO:0009952; GO:0021644; GO:0030855; GO:0030878; GO:0035019; GO:0035176; GO:0035909; GO:0042471; GO:0042472; GO:0042473; GO:0042474; GO:0042475; GO:0042693; GO:0042803; GO:0043410; GO:0043565; GO:0043587; GO:0044344; GO:0045596; GO:0045893; GO:0045944; GO:0046983; GO:0048384; GO:0048514; GO:0048538; GO:0048644; GO:0048701; GO:0048703; GO:0048752; GO:0048844; GO:0050679; GO:0060017; GO:0060023; GO:0060037; GO:0060325; GO:0060415; GO:0060982; GO:0070166; GO:0071300; GO:0090103; GO:0097152; GO:1990837; GO:2000027; GO:2001037; GO:2001054
GN005770	GN005770.1	P22059	51.7	779	770	807	2.44e-258	739	OSBP1_HUMAN	Oxysterol-binding protein 1	Homo sapiens (Human)	bile acid biosynthetic process [GO:0006699]; ceramide transport [GO:0035627]; intracellular cholesterol transport [GO:0032367]; lipid transport [GO:0006869]; phospholipid transport [GO:0015914]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of secretory granule organization [GO:1904411]; sphingomyelin biosynthetic process [GO:0006686]; sterol transport [GO:0015918]	lipid transfer activity [GO:0120013]; oxysterol binding [GO:0008142]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-4-phosphate-cholesterol exchange activity [GO:0160291]; protein domain specific binding [GO:0019904]; sterol transfer activity [GO:0120015]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-trans-Golgi network membrane contact site [GO:0160258]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0005737; GO:0005789; GO:0005794; GO:0005802; GO:0005829; GO:0005886; GO:0006686; GO:0006699; GO:0006869; GO:0008142; GO:0015914; GO:0015918; GO:0016020; GO:0019904; GO:0032367; GO:0035627; GO:0035774; GO:0048471; GO:0070273; GO:0097038; GO:0120013; GO:0120015; GO:0160258; GO:0160291; GO:1904411
GN005775	GN005775.1	Q6P9S0	53.1	335	920	715	5.69e-97	323	MTSS2_MOUSE	Protein MTSS 2 (MTSS1-like protein)	Mus musculus (Mouse)	activation of GTPase activity [GO:0090630]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; lamellipodium organization [GO:0097581]; membrane organization [GO:0061024]; plasma membrane organization [GO:0007009]	actin binding [GO:0003779]; actin monomer binding [GO:0003785]; GTPase activator activity [GO:0005096]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]	actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	GO:0001726; GO:0003779; GO:0003785; GO:0005096; GO:0005543; GO:0005546; GO:0005737; GO:0005886; GO:0005925; GO:0007009; GO:0015629; GO:0030027; GO:0030864; GO:0031267; GO:0032587; GO:0036120; GO:0061024; GO:0090630; GO:0097581
GN005776	GN005776.1	Q9NTZ6	22.9	402	1497	932	9.50e-21	103	RBM12_HUMAN	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN)	Homo sapiens (Human)	regulation of RNA splicing [GO:0043484]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005654; GO:0043484; GO:1990904
GN005778	GN005778.1	P0C152	44.6	607	605	992	3.76e-167	505	MKS3_RAT	Meckelin (Meckel syndrome type 3 protein homolog) (Transmembrane protein 67)	Rattus norvegicus (Rat)	branching morphogenesis of an epithelial tube [GO:0048754]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; ERAD pathway [GO:0036503]; head development [GO:0060322]; heart development [GO:0007507]; kidney development [GO:0001822]; negative regulation of centrosome duplication [GO:0010826]; non-canonical Wnt signaling pathway [GO:0035567]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of non-motile cilium assembly [GO:1902857]	filamin binding [GO:0031005]; misfolded protein binding [GO:0051787]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; MKS complex [GO:0036038]; plasma membrane [GO:0005886]	GO:0001822; GO:0005789; GO:0005813; GO:0005886; GO:0005930; GO:0007368; GO:0007507; GO:0010826; GO:0030659; GO:0031005; GO:0035567; GO:0035845; GO:0035869; GO:0036038; GO:0036503; GO:0048754; GO:0051787; GO:0060170; GO:0060271; GO:0060322; GO:0060441; GO:1902857; GO:1904294
GN005785	GN005785.1	Q642J4	48.2	311	311	317	2.80e-89	272	IMPCT_DANRE	Protein IMPACT (Imprinted and ancient gene protein homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to amino acid starvation [GO:0034198]; GCN2-mediated signaling [GO:0140469]; intracellular signal transduction [GO:0035556]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron projection extension [GO:1990138]; positive regulation of neuron differentiation [GO:0045666]; regulation of cytoplasmic translational initiation in response to stress [GO:1990611]; regulation of translational initiation [GO:0006446]	protein sequestering activity [GO:0140311]	cytoplasm [GO:0005737]	GO:0000122; GO:0005737; GO:0006446; GO:0034198; GO:0035556; GO:0045666; GO:0140311; GO:0140469; GO:1990138; GO:1990611
GN005788	GN005788.1	Q8C3X2	36.8	234	283	256	9.39e-32	121	CC90B_MOUSE	Coiled-coil domain-containing protein 90B, mitochondrial	Mus musculus (Mouse)			mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	GO:0005739; GO:0031966
GN005792	GN005792.1	B5FZ63	87.2	86	90	96	9.24e-40	129	ENY2_TAEGU	Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog)	Taeniopygia guttata (Zebra finch) (Poephila guttata)	poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]	transcription coactivator activity [GO:0003713]	DUBm complex [GO:0071819]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]; transcription export complex 2 [GO:0070390]	GO:0000124; GO:0003713; GO:0005654; GO:0006357; GO:0006368; GO:0016973; GO:0044615; GO:0045893; GO:0070390; GO:0071819
GN005793	GN005793.1	Q68FK8	62.6	974	1065	1262	0.0	1197	DHX9_XENLA	ATP-dependent RNA helicase A protein (EC 3.6.4.13) (DEAH box protein 9) (Nuclear DNA helicase II) (NDH II)	Xenopus laevis (African clawed frog)	alternative mRNA splicing, via spliceosome [GO:0000380]; chromatin organization [GO:0006325]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytoplasmic translation [GO:2000765]; regulation of mRNA processing [GO:0050684]; RISC complex assembly [GO:0070922]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' DNA/RNA helicase activity [GO:0033679]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; G-quadruplex unwinding activity [GO:0160225]; importin-alpha family protein binding [GO:0061676]; mRNA binding [GO:0003729]; nucleoside triphosphate diphosphatase activity [GO:0047429]; promoter-specific chromatin binding [GO:1990841]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosome binding [GO:0043022]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase binding [GO:0070063]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; transcription coactivator activity [GO:0003713]; triplex DNA binding [GO:0045142]	actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; ribonucleoprotein complex [GO:1990904]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]	GO:0000380; GO:0000978; GO:0003677; GO:0003678; GO:0003688; GO:0003690; GO:0003697; GO:0003713; GO:0003723; GO:0003724; GO:0003725; GO:0003727; GO:0003729; GO:0005524; GO:0005634; GO:0005654; GO:0005726; GO:0005730; GO:0005737; GO:0005813; GO:0006325; GO:0015629; GO:0016442; GO:0016604; GO:0016887; GO:0017111; GO:0031490; GO:0033679; GO:0034458; GO:0035195; GO:0035613; GO:0036464; GO:0043022; GO:0043138; GO:0045142; GO:0045739; GO:0045740; GO:0045944; GO:0046833; GO:0047429; GO:0048146; GO:0050684; GO:0061676; GO:0070063; GO:0070578; GO:0070922; GO:0070937; GO:0097165; GO:0160225; GO:1905172; GO:1990518; GO:1990825; GO:1990841; GO:1990904; GO:2000765; GO:2000767
GN005794	GN005794.1	O70133	49.8	213	206	1380	2.02e-52	184	DHX9_MOUSE	ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (mHEL-5) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) (RHA)	Mus musculus (Mouse)	alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to heat [GO:0034605]; chromatin organization [GO:0006325]; circadian rhythm [GO:0007623]; CRD-mediated mRNA stabilization [GO:0070934]; DNA-templated viral transcription [GO:0039695]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of inflammatory response [GO:0050729]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of RNA export from nucleus [GO:0046833]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of viral transcription [GO:0050434]; protein localization to cytoplasmic stress granule [GO:1903608]; pyroptotic inflammatory response [GO:0070269]; regulation of cytoplasmic translation [GO:2000765]; regulation of defense response to virus by host [GO:0050691]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; RISC complex assembly [GO:0070922]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' DNA/RNA helicase activity [GO:0033679]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; catalytic activity, acting on a nucleic acid [GO:0140640]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; G-quadruplex unwinding activity [GO:0160225]; importin-alpha family protein binding [GO:0061676]; mRNA binding [GO:0003729]; nucleoside triphosphate diphosphatase activity [GO:0047429]; promoter-specific chromatin binding [GO:1990841]; regulatory region RNA binding [GO:0001069]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosome binding [GO:0043022]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase binding [GO:0070063]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA stem-loop binding [GO:0035613]; sequence-specific mRNA binding [GO:1990825]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; triplex DNA binding [GO:0045142]	actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear stress granule [GO:0097165]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]	GO:0000380; GO:0000978; GO:0000993; GO:0001069; GO:0003677; GO:0003678; GO:0003688; GO:0003690; GO:0003697; GO:0003712; GO:0003713; GO:0003723; GO:0003724; GO:0003725; GO:0003727; GO:0003729; GO:0005524; GO:0005634; GO:0005654; GO:0005726; GO:0005730; GO:0005737; GO:0005813; GO:0005829; GO:0006325; GO:0006357; GO:0007623; GO:0015629; GO:0016442; GO:0016604; GO:0016887; GO:0017111; GO:0031490; GO:0032727; GO:0032728; GO:0032741; GO:0032755; GO:0032760; GO:0032991; GO:0033679; GO:0034458; GO:0034605; GO:0035195; GO:0035197; GO:0035613; GO:0036464; GO:0039695; GO:0043022; GO:0043138; GO:0045089; GO:0045142; GO:0045739; GO:0045740; GO:0045944; GO:0046833; GO:0047429; GO:0048146; GO:0050434; GO:0050684; GO:0050691; GO:0050729; GO:0060760; GO:0061629; GO:0061676; GO:0070063; GO:0070269; GO:0070578; GO:0070922; GO:0070934; GO:0070937; GO:0071360; GO:0097165; GO:0140640; GO:0160225; GO:1900152; GO:1903608; GO:1905172; GO:1990518; GO:1990825; GO:1990841; GO:1990904; GO:2000765; GO:2000767
GN005795	GN005795.1	Q5R4Q7	56.0	745	695	840	1.51e-288	814	LZTR1_PONAB	Leucine-zipper-like transcriptional regulator 1 (LZTR-1)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	negative regulation of Ras protein signal transduction [GO:0046580]; protein ubiquitination [GO:0016567]	small GTPase binding [GO:0031267]	Cul3-RING ubiquitin ligase complex [GO:0031463]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]	GO:0005794; GO:0012505; GO:0016567; GO:0031267; GO:0031463; GO:0046580; GO:0055037; GO:0055038
GN005797	GN005797.1	Q924H5	53.1	305	321	366	3.19e-105	315	RA51C_MOUSE	DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2)	Mus musculus (Mouse)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; female meiosis sister chromatid cohesion [GO:0007066]; male meiosis I [GO:0007141]; meiotic DNA recombinase assembly [GO:0000707]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; replication fork processing [GO:0031297]; spermatogenesis [GO:0007283]; supramolecular fiber organization [GO:0097435]; telomere maintenance via recombination [GO:0000722]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; crossover junction DNA endonuclease activity [GO:0008821]; four-way junction DNA binding [GO:0000400]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Holliday junction resolvase complex [GO:0048476]; mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; Rad51C-XRCC3 complex [GO:0033065]; replication fork [GO:0005657]	GO:0000400; GO:0000707; GO:0000722; GO:0000724; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005737; GO:0005739; GO:0005829; GO:0006281; GO:0006310; GO:0007066; GO:0007131; GO:0007141; GO:0007283; GO:0008821; GO:0010971; GO:0030054; GO:0031297; GO:0033063; GO:0033065; GO:0043596; GO:0048471; GO:0048476; GO:0097435; GO:0140664
GN005798	GN005798.1	Q6NZQ0	36.2	246	265	333	4.80e-45	157	CF119_MOUSE	Cilia- and flagella-associated protein 119 (Coiled-coil domain-containing protein 189)	Mus musculus (Mouse)	gene expression [GO:0010467]; single fertilization [GO:0007338]; sperm flagellum assembly [GO:0120316]		acrosomal vesicle [GO:0001669]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; radial spoke [GO:0001534]; sperm principal piece [GO:0097228]	GO:0001534; GO:0001669; GO:0005737; GO:0005930; GO:0007338; GO:0010467; GO:0097228; GO:0120316
GN005800	GN005800.1	Q9Z0J4	50.5	1421	1460	1429	0.0	1343	NOS1_MOUSE	Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Nitric oxide synthase, brain) (bNOS) (Peptidyl-cysteine S-nitrosylase NOS1)	Mus musculus (Mouse)	behavioral response to cocaine [GO:0048148]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to growth factor stimulus [GO:0071363]; cellular response to mechanical stimulus [GO:0071260]; establishment of protein localization [GO:0045184]; L-arginine catabolic process [GO:0006527]; multicellular organismal response to stress [GO:0033555]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of hepatic stellate cell contraction [GO:0061875]; negative regulation of hydrolase activity [GO:0051346]; negative regulation of insulin secretion [GO:0046676]; negative regulation of iron ion transmembrane transport [GO:0034760]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of serotonin uptake [GO:0051612]; negative regulation of vasoconstriction [GO:0045906]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide-cGMP-mediated signaling [GO:0038060]; peptidyl-cysteine S-nitrosylation [GO:0018119]; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071879]; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106071]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of sodium ion transmembrane transport [GO:1902307]; positive regulation of the force of heart contraction [GO:0098735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; regulation of postsynaptic membrane potential [GO:0060078]; regulation of sodium ion transport [GO:0002028]; response to estrogen [GO:0043627]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to peptide hormone [GO:0043434]; striated muscle contraction [GO:0006941]; synaptic signaling by nitric oxide [GO:0099163]; vasodilation [GO:0042311]; xenobiotic catabolic process [GO:0042178]	ATPase binding [GO:0051117]; cadmium ion binding [GO:0046870]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; NADP binding [GO:0050661]; NADPH binding [GO:0070402]; nitric-oxide synthase activity [GO:0004517]; peptidyl-cysteine S-nitrosylase activity [GO:0035605]; phosphoprotein binding [GO:0051219]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; scaffold protein binding [GO:0097110]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; zinc ion binding [GO:0008270]	azurophil granule [GO:0042582]; calyx of Held [GO:0044305]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic specialization, intracellular component [GO:0099091]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; secretory granule [GO:0030141]; synapse [GO:0045202]; T-tubule [GO:0030315]; Z disc [GO:0030018]	GO:0001666; GO:0001917; GO:0002028; GO:0004517; GO:0005516; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005741; GO:0005829; GO:0005856; GO:0005886; GO:0006527; GO:0006809; GO:0006941; GO:0008270; GO:0008285; GO:0009408; GO:0009725; GO:0010181; GO:0014069; GO:0016529; GO:0017080; GO:0018119; GO:0019899; GO:0020037; GO:0030018; GO:0030141; GO:0030315; GO:0030425; GO:0031965; GO:0032496; GO:0032991; GO:0033017; GO:0033555; GO:0034760; GO:0035605; GO:0038060; GO:0042178; GO:0042311; GO:0042383; GO:0042582; GO:0042802; GO:0043066; GO:0043197; GO:0043267; GO:0043434; GO:0043524; GO:0043525; GO:0043627; GO:0044305; GO:0044325; GO:0045121; GO:0045184; GO:0045202; GO:0045776; GO:0045893; GO:0045906; GO:0045944; GO:0046676; GO:0046870; GO:0048148; GO:0048306; GO:0048471; GO:0050660; GO:0050661; GO:0050767; GO:0051117; GO:0051219; GO:0051346; GO:0051481; GO:0051612; GO:0051926; GO:0060078; GO:0061629; GO:0061875; GO:0070402; GO:0071260; GO:0071363; GO:0071872; GO:0071879; GO:0071944; GO:0097110; GO:0098735; GO:0098978; GO:0099091; GO:0099092; GO:0099163; GO:0106071; GO:1900273; GO:1902307
GN005801	GN005801.1	Q28C22	49.5	109	105	349	3.28e-31	115	OGFD2_XENTR	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (EC 1.14.11.-)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]		GO:0005506; GO:0016705; GO:0031418
GN005810	GN005810.1	Q5F464	63.8	224	516	604	8.11e-104	326	LPP_CHICK	Lipoma-preferred partner homolog	Gallus gallus (Chicken)	cell-cell adhesion [GO:0098609]		cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; stress fiber [GO:0001725]	GO:0001725; GO:0005634; GO:0005737; GO:0005925; GO:0098609
GN005811	GN005811.1	P10160	61.1	157	157	154	1.04e-63	195	IF5A1_RABIT	Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D)	Oryctolagus cuniculus (Rabbit)	positive regulation of translation [GO:0045727]; translational elongation [GO:0006414]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation elongation factor activity [GO:0003746]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	GO:0003723; GO:0003746; GO:0005634; GO:0005737; GO:0005789; GO:0006414; GO:0043022; GO:0045727
GN005813	GN005813.1	P48612	70.3	377	381	395	1.50e-196	550	PELO_DROME	Protein pelota	Drosophila melanogaster (Fruit fly)	compound eye morphogenesis [GO:0001745]; female germ-line stem cell asymmetric division [GO:0048132]; germ-line stem cell population maintenance [GO:0030718]; male germ-line stem cell population maintenance [GO:0036098]; meiotic cell cycle [GO:0051321]; meiotic nuclear membrane disassembly [GO:0051078]; meiotic spindle organization [GO:0000212]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA catabolic process, non-stop decay [GO:0070481]; post-transcriptional gene silencing [GO:0016441]; rescue of stalled cytosolic ribosome [GO:0072344]; RNA surveillance [GO:0071025]; sperm individualization [GO:0007291]; spermatocyte division [GO:0048137]	stalled ribosome sensor activity [GO:0170011]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; Dom34-Hbs1 complex [GO:1990533]; nucleus [GO:0005634]	GO:0000212; GO:0001745; GO:0005634; GO:0005737; GO:0005829; GO:0007291; GO:0016441; GO:0022626; GO:0030718; GO:0036098; GO:0048132; GO:0048137; GO:0051078; GO:0051321; GO:0070481; GO:0070966; GO:0071025; GO:0072344; GO:0170011; GO:1990533
GN005816	GN005816.1	Q9GZV8	54.5	264	295	571	1.78e-88	277	PRD14_HUMAN	PR domain zinc finger protein 14 (EC 2.1.1.-) (PR domain-containing protein 14)	Homo sapiens (Human)	positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin DNA binding [GO:0031490]; histone methyltransferase binding [GO:1990226]; methyltransferase regulator activity [GO:0141107]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000977; GO:0003723; GO:0005634; GO:0005654; GO:0006357; GO:0031490; GO:0141107; GO:1902093; GO:1902459; GO:1990226
GN005817	GN005817.1	A6H5Y1	28.2	216	1821	1114	5.54e-12	75.1	MPP9_MOUSE	M-phase phosphoprotein 9	Mus musculus (Mouse)	negative regulation of cilium assembly [GO:1902018]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005794; GO:0005813; GO:0005814; GO:0036064; GO:1902018
GN005818	GN005818.1	Q80VP5	48.3	120	142	184	9.16e-27	101	MTRFR_MOUSE	Mitochondrial translation release factor in rescue	Mus musculus (Mouse)	rescue of stalled cytosolic ribosome [GO:0072344]; rescue of stalled mitochondrial ribosome [GO:7770016]	ribosomal large subunit binding [GO:0043023]; translation release factor activity, codon specific [GO:0016149]; tRNA binding [GO:0000049]	mitochondrion [GO:0005739]	GO:0000049; GO:0005739; GO:0016149; GO:0043023; GO:0072344; GO:7770016
GN005819	GN005819.1	P13420	52.2	136	190	217	2.20e-37	131	NUDT6_XENLA	Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (EC 3.6.1.-) (Protein GFG)	Xenopus laevis (African clawed frog)		ADP-ribose diphosphatase activity [GO:0047631]; FAD diphosphatase activity [GO:0047884]; NAD binding [GO:0051287]; NADH pyrophosphatase activity [GO:0035529]	mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005739; GO:0035529; GO:0047631; GO:0047884; GO:0051287
GN005822	GN005822.1	Q4G0P3	42.7	5409	5321	5121	0.0	3988	HYDIN_HUMAN	Axonemal central pair apparatus protein HYDIN (Hydrocephalus-inducing protein homolog)	Homo sapiens (Human)	axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]		axonemal central apparatus [GO:1990716]; axonemal central pair projection [GO:1990718]; axoneme [GO:0005930]; cilium [GO:0005929]; sperm flagellum [GO:0036126]	GO:0003341; GO:0005929; GO:0005930; GO:0036126; GO:1904158; GO:1990716; GO:1990718
GN005823	GN005823.1	Q6TMK8	39.8	181	230	195	9.63e-36	128	PLD3B_CRIGR	PRELI domain containing protein 3B (BCR/ABL-regulated protein) (Protein slowmo homolog 2)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	intermembrane phospholipid transfer [GO:0120010]; mitochondrial membrane organization [GO:0007006]	phosphatidylserine transfer activity [GO:0140343]	mitochondrial intermembrane space [GO:0005758]	GO:0005758; GO:0007006; GO:0120010; GO:0140343
GN005824	GN005824.1	Q21502	22.3	542	1264	870	2.09e-11	72.4	MEP1_CAEEL	MOG interacting and ectopic P-granules protein 1 (Nuclear zinc finger protein)	Caenorhabditis elegans	gonad development [GO:0008406]; nematode larval development [GO:0002119]; oocyte development [GO:0048599]; positive regulation of gene expression [GO:0010628]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; vulval development [GO:0040025]	DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription factor activity [GO:0003700]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]	GO:0000976; GO:0002119; GO:0003700; GO:0003723; GO:0005634; GO:0006355; GO:0008406; GO:0010468; GO:0010628; GO:0017151; GO:0040025; GO:0042802; GO:0042826; GO:0048599
GN005825	GN005825.1	Q9DAR0	40.0	130	136	182	1.98e-23	92.8	CFA90_MOUSE	Cilia- and flagella-associated protein 90 (Y regulated sperm protein)	Mus musculus (Mouse)	flagellated sperm motility [GO:0030317]		axonemal B tubule inner sheath [GO:0160112]; axoneme [GO:0005930]; ciliary basal body [GO:0036064]; sperm flagellum [GO:0036126]	GO:0005930; GO:0030317; GO:0036064; GO:0036126; GO:0160112
GN005826	GN005826.1	Q8BVR6	60.5	296	354	576	1.20e-115	350	RSPRY_MOUSE	RING finger and SPRY domain-containing protein 1	Mus musculus (Mouse)		ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	GO:0004842; GO:0005576; GO:0005737
GN005830	GN005830.1	Q2T9W1	33.1	157	188	316	6.48e-22	93.6	SNX20_BOVIN	Sorting nexin-20	Bos taurus (Bovine)	protein transport [GO:0015031]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005546; GO:0005634; GO:0005737; GO:0005886; GO:0015031; GO:0031901; GO:0032266; GO:0035091; GO:1901981
GN005831	GN005831.1	Q8N4N3	30.4	135	647	616	8.89e-10	65.5	KLH36_HUMAN	Kelch-like protein 36	Homo sapiens (Human)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	cullin family protein binding [GO:0097602]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]	GO:0016567; GO:0031463; GO:0043161; GO:0097602; GO:1990756
GN005835	GN005835.1	Q5R541	32.2	171	337	296	2.95e-09	60.8	GEM_PONAB	GTP-binding protein GEM	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)		calcium channel regulator activity [GO:0005246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]	GO:0003924; GO:0005246; GO:0005525; GO:0005886
GN005836	GN005836.1	Q94BV5	36.5	403	431	452	1.92e-77	250	GSXL4_ARATH	Flavin-containing monooxygenase FMO GS-OX-like 4 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 4)	Arabidopsis thaliana (Mouse-ear cress)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	nucleus [GO:0005634]; plant-type vacuole [GO:0000325]	GO:0000325; GO:0004499; GO:0005634; GO:0050660; GO:0050661
GN005837	GN005837.1	V5NAL9	33.2	732	721	899	6.49e-110	357	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN005838	GN005838.1	Q94BV5	35.9	217	257	452	2.61e-41	150	GSXL4_ARATH	Flavin-containing monooxygenase FMO GS-OX-like 4 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 4)	Arabidopsis thaliana (Mouse-ear cress)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	nucleus [GO:0005634]; plant-type vacuole [GO:0000325]	GO:0000325; GO:0004499; GO:0005634; GO:0050660; GO:0050661
GN005839	GN005839.1	Q94BV5	38.5	213	257	452	1.24e-43	156	GSXL4_ARATH	Flavin-containing monooxygenase FMO GS-OX-like 4 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 4)	Arabidopsis thaliana (Mouse-ear cress)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	nucleus [GO:0005634]; plant-type vacuole [GO:0000325]	GO:0000325; GO:0004499; GO:0005634; GO:0050660; GO:0050661
GN005841	GN005841.1	Q8MP06	47.0	66	67	456	2.21e-10	57.4	SNO1_TYRJA	Senecionine N-oxygenase (SNO) (EC 1.14.13.101)	Tyria jacobaeae (Cinnabar moth)	alkaloid metabolic process [GO:0009820]; protein homotetramerization [GO:0051289]	flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; senecionine N-oxygenase activity [GO:0033784]	extracellular region [GO:0005576]	GO:0004499; GO:0005576; GO:0009820; GO:0033784; GO:0050660; GO:0050661; GO:0051289
GN005843	GN005843.1	Q7YR26	68.2	556	913	767	9.44e-275	785	TOP1_CHLAE	DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)	Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)	chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; circadian regulation of gene expression [GO:0032922]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0003677; GO:0003682; GO:0003917; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0006260; GO:0006265; GO:0006338; GO:0007059; GO:0032922
GN005844	GN005844.1	Q8IRG6	69.5	617	738	1083	4.80e-305	867	SPT16_DROME	FACT complex subunit spt16 (Facilitates chromatin transcription complex subunit SPT16) (dSPT16)	Drosophila melanogaster (Fruit fly)	chromatin remodeling [GO:0006338]; nucleosome disassembly [GO:0006337]; nucleosome organization [GO:0034728]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; regulation of chromatin organization [GO:1902275]; regulation of DNA-templated transcription elongation [GO:0032784]; transcription elongation-coupled chromatin remodeling [GO:0140673]; transcription pausing by RNA polymerase II [GO:0160239]	chromatin binding [GO:0003682]; H2A-H2B histone complex chaperone activity [GO:0000511]; nucleosome binding [GO:0031491]; protein heterodimerization activity [GO:0046982]	cytosol [GO:0005829]; FACT complex [GO:0035101]; nucleolus [GO:0005730]; nucleus [GO:0005634]; polytene chromosome puff [GO:0005703]	GO:0000511; GO:0003682; GO:0005634; GO:0005703; GO:0005730; GO:0005829; GO:0006337; GO:0006338; GO:0031491; GO:0032784; GO:0032786; GO:0034728; GO:0035101; GO:0046982; GO:0140673; GO:0160239; GO:1902275
GN005845	GN005845.1	P26696	85.4	342	366	361	9.67e-218	602	MK01_XENLA	Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (M phase MAP kinase) (Myelin basic protein kinase) (MBP kinase) (Myelin xP42 protein kinase)	Xenopus laevis (African clawed frog)	cell surface receptor signaling pathway [GO:0007166]; intracellular signal transduction [GO:0035556]; mitotic spindle assembly checkpoint signaling [GO:0007094]; positive regulation of smoothened signaling pathway [GO:0045880]; response to epidermal growth factor [GO:0070849]	ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]	GO:0004674; GO:0004707; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0007094; GO:0007166; GO:0035556; GO:0045880; GO:0070849; GO:0072686; GO:0106310
GN005848	GN005848.1	Q8MJ08	30.8	341	344	492	7.20e-36	139	PE2R4_BOVIN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0007188; GO:0007189; GO:0007204; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN005852	GN005852.1	Q20929	28.5	344	372	510	2.20e-30	124	DMSR1_CAEEL	G protein-coupled receptor dmsr-1 (Dromyosuppressin receptor related 1)	Caenorhabditis elegans	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of cellular response to heat [GO:1900034]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008188; GO:0008528; GO:0032809; GO:0045187; GO:1900034
GN005854	GN005854.1	D3YWJ0	33.8	275	1185	796	9.90e-30	131	SLIP_MOUSE	Nuclear GTPase SLIP-GC (EC 3.6.1.-) (Speckled-like pattern in the germinal center)	Mus musculus (Mouse)	cellular response to lipopolysaccharide [GO:0071222]; DNA damage response [GO:0006974]; negative regulation of apoptotic process [GO:0043066]; regulation of nuclear cell cycle DNA replication [GO:0033262]; somatic hypermutation of immunoglobulin genes [GO:0016446]	GTPase activity [GO:0003924]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003924; GO:0005634; GO:0005654; GO:0005829; GO:0006974; GO:0016446; GO:0016607; GO:0033262; GO:0043066; GO:0071222
GN005857	GN005857.1	Q6NV18	29.5	193	241	309	9.67e-09	58.2	NHEJ1_DANRE	Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor)	Danio rerio (Zebrafish) (Brachydanio rerio)	double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; telomere maintenance [GO:0000723]	DNA end binding [GO:0045027]	chromosome [GO:0005694]; DNA ligase IV complex [GO:0032807]; nonhomologous end joining complex [GO:0070419]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000723; GO:0005634; GO:0005694; GO:0006303; GO:0032807; GO:0033152; GO:0035861; GO:0045027; GO:0070419
GN005859	GN005859.1	Q08AE8	47.3	334	1334	756	2.93e-75	270	SPIR1_HUMAN	Protein spire homolog 1 (Spir-1)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; actin filament network formation [GO:0051639]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; Golgi vesicle transport [GO:0048193]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of mitochondrial fission [GO:0090141]; vesicle-mediated transport [GO:0016192]	actin binding [GO:0003779]; microtubule binding [GO:0008017]	cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0003779; GO:0005741; GO:0005829; GO:0005856; GO:0005886; GO:0005938; GO:0008017; GO:0016192; GO:0030036; GO:0030659; GO:0036089; GO:0040038; GO:0045010; GO:0046907; GO:0048193; GO:0048471; GO:0051295; GO:0051639; GO:0070649; GO:0090141; GO:2000781
GN005860	GN005860.1	Q5ZIW5	47.1	68	74	780	1.05e-09	55.8	VAC14_CHICK	Protein VAC14 homolog	Gallus gallus (Chicken)	phosphatidylinositol biosynthetic process [GO:0006661]		endosome membrane [GO:0010008]; PAS complex [GO:0070772]	GO:0006661; GO:0010008; GO:0070772
GN005861	GN005861.1	Q9Y4A0	27.0	318	458	524	3.07e-10	65.9	JERKL_HUMAN	Jerky protein homolog-like (Human homolog of mouse jerky gene protein) (HHMJG)	Homo sapiens (Human)	central nervous system development [GO:0007417]	DNA binding [GO:0003677]	nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0007417
GN005862	GN005862.1	Q66L58	39.8	294	309	771	6.10e-45	166	VAC14_DANRE	Protein VAC14 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	phosphatidylinositol biosynthetic process [GO:0006661]		endosome membrane [GO:0010008]; PAS complex [GO:0070772]	GO:0006661; GO:0010008; GO:0070772
GN005863	GN005863.1	Q66L58	64.0	264	407	771	1.90e-112	349	VAC14_DANRE	Protein VAC14 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	phosphatidylinositol biosynthetic process [GO:0006661]		endosome membrane [GO:0010008]; PAS complex [GO:0070772]	GO:0006661; GO:0010008; GO:0070772
GN005865	GN005865.1	P55088	50.8	248	318	323	4.15e-84	259	AQP4_MOUSE	Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)	Mus musculus (Mouse)	carbon dioxide transport [GO:0015670]; cell-cell adhesion [GO:0098609]; cellular response to glucose stimulus [GO:0071333]; cellular response to type II interferon [GO:0071346]; cerebrospinal fluid circulation [GO:0090660]; cerebrospinal fluid secretion [GO:0033326]; intracellular water homeostasis [GO:0009992]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; protein homotetramerization [GO:0051289]; regulation of vascular endothelial growth factor production [GO:0010574]; renal water absorption [GO:0070295]; sensory perception of sound [GO:0007605]; water transport [GO:0006833]	identical protein binding [GO:0042802]; water channel activity [GO:0015250]	astrocyte end-foot [GO:0097450]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]	GO:0005576; GO:0005737; GO:0005886; GO:0005911; GO:0006833; GO:0007605; GO:0009897; GO:0009925; GO:0009992; GO:0010008; GO:0010574; GO:0015250; GO:0015670; GO:0016020; GO:0016323; GO:0030054; GO:0030315; GO:0031253; GO:0032691; GO:0032715; GO:0032991; GO:0033326; GO:0042383; GO:0042802; GO:0050891; GO:0051289; GO:0060354; GO:0070295; GO:0071333; GO:0071346; GO:0090660; GO:0097450; GO:0098609
GN005868	GN005868.1	P55088	44.6	260	315	323	2.12e-66	214	AQP4_MOUSE	Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)	Mus musculus (Mouse)	carbon dioxide transport [GO:0015670]; cell-cell adhesion [GO:0098609]; cellular response to glucose stimulus [GO:0071333]; cellular response to type II interferon [GO:0071346]; cerebrospinal fluid circulation [GO:0090660]; cerebrospinal fluid secretion [GO:0033326]; intracellular water homeostasis [GO:0009992]; multicellular organismal-level water homeostasis [GO:0050891]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; protein homotetramerization [GO:0051289]; regulation of vascular endothelial growth factor production [GO:0010574]; renal water absorption [GO:0070295]; sensory perception of sound [GO:0007605]; water transport [GO:0006833]	identical protein binding [GO:0042802]; water channel activity [GO:0015250]	astrocyte end-foot [GO:0097450]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; cell projection membrane [GO:0031253]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]	GO:0005576; GO:0005737; GO:0005886; GO:0005911; GO:0006833; GO:0007605; GO:0009897; GO:0009925; GO:0009992; GO:0010008; GO:0010574; GO:0015250; GO:0015670; GO:0016020; GO:0016323; GO:0030054; GO:0030315; GO:0031253; GO:0032691; GO:0032715; GO:0032991; GO:0033326; GO:0042383; GO:0042802; GO:0050891; GO:0051289; GO:0060354; GO:0070295; GO:0071333; GO:0071346; GO:0090660; GO:0097450; GO:0098609
GN005869	GN005869.1	B0JZG0	48.6	516	712	649	8.53e-155	466	S23A2_XENTR	Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	L-ascorbic acid transmembrane transport [GO:0015882]	L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0005886; GO:0008520; GO:0015229; GO:0015882; GO:0016324
GN005870	GN005870.1	Q04678	57.0	546	665	706	1.57e-186	548	SSRP1_CHICK	FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (T160)	Gallus gallus (Chicken)	regulation of chromatin organization [GO:1902275]	DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0005694; GO:0005730; GO:0031491; GO:0042393; GO:1902275
GN005872	GN005872.1	Q04678	71.7	46	66	706	1.82e-14	68.9	SSRP1_CHICK	FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (T160)	Gallus gallus (Chicken)	regulation of chromatin organization [GO:1902275]	DNA binding [GO:0003677]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0005694; GO:0005730; GO:0031491; GO:0042393; GO:1902275
GN005874	GN005874.1	P20807	52.0	102	271	821	6.92e-32	127	CAN3_HUMAN	Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1)	Homo sapiens (Human)	apoptotic process [GO:0006915]; calcium-dependent self proteolysis [GO:1990092]; cellular response to calcium ion [GO:0071277]; cellular response to salt stress [GO:0071472]; G1 to G0 transition involved in cell differentiation [GO:0070315]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein sumoylation [GO:0033234]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014718]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to membrane [GO:0072657]; protein-containing complex assembly [GO:0065003]; proteolysis [GO:0006508]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of myoblast differentiation [GO:0045661]; response to calcium ion [GO:0051592]; response to muscle activity [GO:0014850]; sarcomere organization [GO:0045214]; self proteolysis [GO:0097264]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; catalytic activity [GO:0003824]; cysteine-type peptidase activity [GO:0008234]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; peptidase activity [GO:0008233]; sodium ion binding [GO:0031402]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; myofibril [GO:0030016]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; T-tubule [GO:0030315]; Z disc [GO:0030018]	GO:0003824; GO:0004198; GO:0005509; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0006508; GO:0006915; GO:0007517; GO:0008233; GO:0008234; GO:0008307; GO:0014718; GO:0014850; GO:0030016; GO:0030018; GO:0030163; GO:0030239; GO:0030315; GO:0031402; GO:0031432; GO:0031648; GO:0032991; GO:0033234; GO:0042802; GO:0043066; GO:0043122; GO:0045214; GO:0045661; GO:0045862; GO:0045892; GO:0045893; GO:0046716; GO:0051281; GO:0051592; GO:0060090; GO:0061061; GO:0065003; GO:0070315; GO:0071277; GO:0071472; GO:0072657; GO:0097264; GO:1990092
GN005883	GN005883.1	Q9QZ67	51.9	183	206	598	1.35e-58	196	PPM1D_MOUSE	Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)	Mus musculus (Mouse)	cellular response to starvation [GO:0009267]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of gene expression, epigenetic [GO:0045814]; peptidyl-threonine dephosphorylation [GO:0035970]; regulation of intracellular signal transduction [GO:1902531]; response to bacterium [GO:0009617]	cation binding [GO:0043169]; mitogen-activated protein kinase binding [GO:0051019]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000086; GO:0004722; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0006346; GO:0009267; GO:0009617; GO:0030330; GO:0035970; GO:0043169; GO:0045814; GO:0051019; GO:1902531
GN005885	GN005885.1	Q6DJ48	39.4	216	262	368	2.13e-37	138	STN1_XENTR	CST complex subunit STN1 (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]	single-stranded telomeric DNA binding [GO:0043047]; telomeric repeat DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; CST complex [GO:1990879]; nucleus [GO:0005634]	GO:0000723; GO:0000781; GO:0005634; GO:0010833; GO:0016233; GO:0042162; GO:0043047; GO:1990879
GN005886	GN005886.1	P27365	32.6	359	358	373	6.87e-41	150	3BHS1_MACMU	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1)	Macaca mulatta (Rhesus macaque)	androgen biosynthetic process [GO:0006702]; C21-steroid hormone metabolic process [GO:0008207]; steroid biosynthetic process [GO:0006694]	3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity [GO:0003854]; 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity [GO:0000253]; 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity [GO:0047024]; steroid Delta-isomerase activity [GO:0004769]	ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]	GO:0000253; GO:0003854; GO:0004769; GO:0005737; GO:0005789; GO:0006694; GO:0006702; GO:0008207; GO:0031966; GO:0035869; GO:0047024
GN005887	GN005887.1	Q2KN95	32.7	831	1102	1113	8.70e-81	290	CYTSA_TETNG	Cytospin-A (SPECC1-like protein) (Sperm antigen with calponin homology and coiled-coil domains 1-like)	Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)			gap junction [GO:0005921]; spindle [GO:0005819]	GO:0005819; GO:0005921
GN005888	GN005888.1	Q9CWQ2	52.5	99	108	152	1.26e-29	106	ZSWM7_MOUSE	Zinc finger SWIM domain-containing protein 7 (SWIM domain-containing and Srs2-interacting protein 1 homolog)	Mus musculus (Mouse)	DNA recombinase assembly [GO:0000730]; double-strand break repair involved in meiotic recombination [GO:1990918]; double-strand break repair via homologous recombination [GO:0000724]; protein stabilization [GO:0050821]	zinc ion binding [GO:0008270]	chromosome [GO:0005694]; nucleus [GO:0005634]; Shu complex [GO:0097196]	GO:0000724; GO:0000730; GO:0005634; GO:0005694; GO:0008270; GO:0050821; GO:0097196; GO:1990918
GN005889	GN005889.1	Q9VI04	76.0	225	226	386	5.67e-127	367	BUP1_DROME	Beta-ureidopropionase pyd3 (EC 3.5.1.6) (N-carbamoyl-beta-alanine amidohydrolase) (beta-Alanine synthase)	Drosophila melanogaster (Fruit fly)	beta-alanine biosynthetic process [GO:0019483]; pyrimidine nucleobase catabolic process [GO:0006208]	beta-ureidopropionase activity [GO:0003837]	cytoplasm [GO:0005737]	GO:0003837; GO:0005737; GO:0006208; GO:0019483
GN005890	GN005890.1	Q9JK25	40.1	489	1438	1320	2.09e-69	260	CLIP1_RAT	CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 170) (CLIP-170) (Restin)	Rattus norvegicus (Rat)	cytoplasmic microtubule organization [GO:0031122]; microtubule bundle formation [GO:0001578]; positive regulation of dendrite development [GO:1900006]; positive regulation of microtubule polymerization [GO:0031116]; protein transport into plasma membrane raft [GO:0044861]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; macropinosome [GO:0044354]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; ruffle [GO:0001726]	GO:0001578; GO:0001726; GO:0005634; GO:0005635; GO:0005813; GO:0005829; GO:0005874; GO:0005881; GO:0005938; GO:0008017; GO:0008270; GO:0015630; GO:0015631; GO:0030659; GO:0031116; GO:0031122; GO:0035371; GO:0042802; GO:0044354; GO:0044861; GO:0051010; GO:1900006
GN005895	GN005895.1	Q7JK24	33.1	299	306	326	2.30e-50	172	B3GT1_GORGO	Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)	Gorilla gorilla gorilla (Western lowland gorilla)	glucosylceramide metabolic process [GO:0006678]; glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006678; GO:0008499; GO:0009101; GO:0009312
GN005896	GN005896.1	Q99JA8	30.8	130	145	151	4.72e-13	65.5	NGB_RAT	Neuroglobin (Nitrite reductase) (EC 1.7.-.-)	Rattus norvegicus (Rat)	cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; negative regulation of apoptotic process [GO:0043066]; neuron projection development [GO:0031175]; oxygen transport [GO:0015671]; positive regulation of catalytic activity [GO:0043085]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]	GDP-dissociation inhibitor activity [GO:0005092]; heme binding [GO:0020037]; nitrite reductase activity [GO:0098809]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; perikaryon [GO:0043204]	GO:0001666; GO:0005092; GO:0005344; GO:0005759; GO:0005829; GO:0010039; GO:0015671; GO:0019825; GO:0020037; GO:0031175; GO:0043066; GO:0043085; GO:0043204; GO:0070301; GO:0071456; GO:0098809
GN005898	GN005898.1	Q15056	39.9	278	292	248	2.88e-43	151	IF4H_HUMAN	Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein)	Homo sapiens (Human)	regulation of translational initiation [GO:0006446]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	GO:0003723; GO:0003743; GO:0005829; GO:0006446; GO:0008135; GO:0016020; GO:0016281; GO:0045296; GO:0048471
GN005901	GN005901.1	O36022	35.9	273	375	337	1.41e-37	141	MNN9_SCHPO	Mannan polymerase complex subunit mnn9	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	cell wall mannoprotein biosynthetic process [GO:0000032]; protein N-linked glycosylation [GO:0006487]	mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mannan polymerase complex [GO:0000136]; mannan polymerase II complex [GO:0140497]	GO:0000030; GO:0000032; GO:0000136; GO:0000139; GO:0005783; GO:0005789; GO:0005794; GO:0006487; GO:0140497
GN005906	GN005906.1	Q9Y2Q3	42.7	178	180	226	8.26e-48	158	GSTK1_HUMAN	Glutathione S-transferase kappa 1 (EC 2.5.1.18) (GST 13-13) (GST class-kappa) (GSTK1-1) (hGSTK1) (Glutathione S-transferase subunit 13)	Homo sapiens (Human)	epithelial cell differentiation [GO:0030855]; glutathione metabolic process [GO:0006749]; liver development [GO:0001889]; response to arsenic-containing substance [GO:0046685]; response to manganese ion [GO:0010042]	glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0001889; GO:0004364; GO:0004602; GO:0005739; GO:0005759; GO:0005777; GO:0005782; GO:0005829; GO:0006749; GO:0010042; GO:0016020; GO:0030855; GO:0046685; GO:0070062
GN005907	GN005907.1	Q9JHX4	31.9	279	532	482	3.21e-33	135	CASP8_RAT	Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]	Rattus norvegicus (Rat)	angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; heart development [GO:0007507]; hepatocyte apoptotic process [GO:0097284]; macrophage differentiation [GO:0030225]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of necroptotic process [GO:0060546]; neural tube formation [GO:0001841]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of proteolysis [GO:0045862]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of cytokine production [GO:0001817]; regulation of innate immune response [GO:0045088]; regulation of thymocyte apoptotic process [GO:0070243]; response to anesthetic [GO:0072347]; response to auditory stimulus [GO:0010996]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; self proteolysis [GO:0097264]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; ubiquitin protein ligase binding [GO:0031625]	caspase complex [GO:0008303]; CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; lamellipodium [GO:0030027]; Noc1p-Noc2p complex [GO:0030690]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ripoptosome [GO:0097342]	GO:0001525; GO:0001817; GO:0001841; GO:0004175; GO:0004197; GO:0005123; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006508; GO:0006915; GO:0007507; GO:0008233; GO:0008303; GO:0008625; GO:0008656; GO:0010996; GO:0016485; GO:0030027; GO:0030163; GO:0030225; GO:0030335; GO:0030690; GO:0031264; GO:0031265; GO:0031625; GO:0032025; GO:0032355; GO:0032496; GO:0032731; GO:0032991; GO:0034612; GO:0035877; GO:0036462; GO:0042802; GO:0043065; GO:0043123; GO:0043124; GO:0043525; GO:0044297; GO:0044877; GO:0045088; GO:0045471; GO:0045651; GO:0045862; GO:0051604; GO:0060546; GO:0070243; GO:0070269; GO:0071260; GO:0072347; GO:0097110; GO:0097190; GO:0097191; GO:0097194; GO:0097264; GO:0097284; GO:0097342; GO:1900119; GO:2001233; GO:2001238
GN005908	GN005908.1	Q7T356	58.4	243	249	242	2.25e-87	262	143BB_DANRE	14-3-3 protein beta/alpha-B	Danio rerio (Zebrafish) (Brachydanio rerio)	intracellular protein localization [GO:0008104]		cytoplasm [GO:0005737]	GO:0005737; GO:0008104
GN005909	GN005909.1	Q04917	59.5	247	251	246	8.94e-91	271	1433F_HUMAN	14-3-3 protein eta (Protein AS1)	Homo sapiens (Human)	glucocorticoid catabolic process [GO:0006713]; intracellular protein localization [GO:0008104]; intracellular protein transport [GO:0006886]; membrane depolarization during action potential [GO:0086010]; negative regulation of dendrite morphogenesis [GO:0050774]; nuclear receptor-mediated glucocorticoid signaling pathway [GO:0042921]; positive regulation of DNA-templated transcription [GO:0045893]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of neuron differentiation [GO:0045664]; regulation of sodium ion transport [GO:0002028]; regulation of synaptic plasticity [GO:0048167]; substantia nigra development [GO:0021762]	actin binding [GO:0003779]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; insulin-like growth factor receptor binding [GO:0005159]; nuclear glucocorticoid receptor binding [GO:0035259]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]	cerebellar granule cell to Purkinje cell synapse [GO:0150048]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0002028; GO:0003779; GO:0005159; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006713; GO:0006886; GO:0008104; GO:0014704; GO:0017080; GO:0019899; GO:0019904; GO:0021762; GO:0035259; GO:0042802; GO:0042921; GO:0044325; GO:0045664; GO:0045893; GO:0046982; GO:0048167; GO:0050774; GO:0070062; GO:0086010; GO:0098793; GO:0099171; GO:0150048
GN005910	GN005910.1	Q99700	47.8	136	390	1313	1.16e-21	100	ATX2_HUMAN	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	Homo sapiens (Human)	negative regulation of receptor internalization [GO:0002091]; P-body assembly [GO:0033962]; regulation of translation [GO:0006417]; RNA metabolic process [GO:0016070]; RNA transport [GO:0050658]; stress granule assembly [GO:0034063]	epidermal growth factor receptor binding [GO:0005154]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]; trans-Golgi network [GO:0005802]	GO:0002091; GO:0003723; GO:0005154; GO:0005737; GO:0005794; GO:0005802; GO:0006417; GO:0010494; GO:0016020; GO:0016070; GO:0033962; GO:0034063; GO:0048471; GO:0050658; GO:1990904
GN005911	GN005911.1	P17644	39.2	362	462	576	2.73e-81	265	ACH2_DROME	Acetylcholine receptor subunit alpha-like 2 (Nicotinic acetylcholine receptor alpha 2)	Drosophila melanogaster (Fruit fly)	calcium ion transport [GO:0006816]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0098655
GN005913	GN005913.1	E9QHE3	37.8	135	173	634	1.67e-22	96.7	RN207_DANRE	RING finger protein 207	Danio rerio (Zebrafish) (Brachydanio rerio)	positive regulation of membrane repolarization during cardiac muscle cell action potential [GO:1905033]; positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905026]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207]	Hsp70 protein binding [GO:0030544]; transmembrane transporter binding [GO:0044325]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]	GO:0005737; GO:0008270; GO:0030544; GO:0044325; GO:0048471; GO:0055117; GO:1901207; GO:1905026; GO:1905033
GN005914	GN005914.1	Q8BLQ7	49.2	581	638	635	4.17e-172	507	CTR4_MOUSE	Cationic amino acid transporter 4 (CAT-4) (CAT4) (Solute carrier family 7 member 4)	Mus musculus (Mouse)	amino acid transport [GO:0006865]	amino acid transmembrane transporter activity [GO:0015171]; carboxylic acid transmembrane transporter activity [GO:0046943]	plasma membrane [GO:0005886]	GO:0005886; GO:0006865; GO:0015171; GO:0046943
GN005919	GN005919.1	Q53HC5	38.2	191	229	615	1.49e-38	144	KLH26_HUMAN	Kelch-like protein 26	Homo sapiens (Human)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]	GO:0031463; GO:0043161; GO:1990756
GN005922	GN005922.1	Q9NRH2	73.0	348	942	765	2.47e-168	513	SNRK_HUMAN	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase)	Homo sapiens (Human)	myeloid cell differentiation [GO:0030099]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	nucleus [GO:0005634]	GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0006468; GO:0030099; GO:0106310
GN005923	GN005923.1	Q9XT77	43.6	525	562	636	2.98e-127	389	SC5A6_RABIT	Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6)	Oryctolagus cuniculus (Rabbit)	biotin import across plasma membrane [GO:1905135]; biotin transport [GO:0015878]; iodide transmembrane transport [GO:1904200]; pantothenate transmembrane transport [GO:0015887]	biotin transmembrane transporter activity [GO:0015225]; iodide transmembrane transporter activity [GO:0015111]; sodium-dependent multivitamin transmembrane transporter activity [GO:0008523]; vitamin transmembrane transporter activity [GO:0090482]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0005886; GO:0008523; GO:0015111; GO:0015225; GO:0015878; GO:0015887; GO:0016324; GO:0090482; GO:1904200; GO:1905135
GN005933	GN005933.1	Q9ET77	45.4	293	684	744	1.15e-31	135	JPH3_MOUSE	Junctophilin-3 (JP-3) (Junctophilin type 3)	Mus musculus (Mouse)	exploration behavior [GO:0035640]; learning [GO:0007612]; locomotion [GO:0040011]; memory [GO:0007613]; neuromuscular process controlling balance [GO:0050885]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of synaptic plasticity [GO:0048167]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005783; GO:0005789; GO:0005886; GO:0007612; GO:0007613; GO:0016020; GO:0030314; GO:0035640; GO:0040011; GO:0048167; GO:0048168; GO:0050885; GO:0060314
GN005936	GN005936.1	Q9ET80	85.6	125	174	660	2.41e-40	147	JPH1_MOUSE	Junctophilin-1 (JP-1) (Junctophilin type 1)	Mus musculus (Mouse)	muscle organ development [GO:0007517]	structural constituent of muscle [GO:0008307]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; Z disc [GO:0030018]	GO:0005654; GO:0005783; GO:0005789; GO:0005886; GO:0007517; GO:0008307; GO:0014701; GO:0016529; GO:0030018; GO:0030314
GN005939	GN005939.1	A9JR78	34.2	120	161	1427	6.65e-10	60.1	TONSL_DANRE	Tonsoku-like protein (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	double-strand break repair via homologous recombination [GO:0000724]; replication fork processing [GO:0031297]	histone binding [GO:0042393]; histone reader activity [GO:0140566]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear replication fork [GO:0043596]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000724; GO:0005634; GO:0005694; GO:0005737; GO:0031297; GO:0035861; GO:0042393; GO:0043596; GO:0140566
GN005940	GN005940.1	Q5R8P3	22.7	428	437	723	3.12e-16	84.7	BBS10_PONAB	BBSome complex assembly protein BBS10 (Bardet-Biedl syndrome 10 protein homolog)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	chaperone-mediated protein complex assembly [GO:0051131]	ATP binding [GO:0005524]	cilium [GO:0005929]	GO:0005524; GO:0005929; GO:0051131
GN005945	GN005945.1	Q9HCD5	32.2	379	697	579	9.16e-31	131	NCOA5_HUMAN	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of signal transduction [GO:0009966]	chromatin binding [GO:0003682]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]	actin cytoskeleton [GO:0015629]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]	GO:0000122; GO:0003682; GO:0003714; GO:0003723; GO:0005576; GO:0005654; GO:0009966; GO:0015629
GN005946	GN005946.1	Q28DH9	56.9	547	545	661	9.81e-233	659	CEP76_XENTR	Centrosomal protein of 76 kDa (Cep76)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	regulation of centriole replication [GO:0046599]		centriole [GO:0005814]; centrosome [GO:0005813]	GO:0005813; GO:0005814; GO:0046599
GN005950	GN005950.1	P67827	93.6	282	323	325	3.82e-195	541	KC1A_BOVIN	Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1)	Bos taurus (Bovine)	intermediate filament cytoskeleton organization [GO:0045104]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; nuclear speck [GO:0016607]; spindle [GO:0005819]	GO:0000139; GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005813; GO:0005819; GO:0006468; GO:0016607; GO:0018105; GO:0036064; GO:0045104; GO:0090090; GO:0106310; GO:1900226
GN005951	GN005951.1	O35231	55.7	447	720	824	6.08e-161	488	KIFC3_MOUSE	Kinesin-like protein KIFC3	Mus musculus (Mouse)	epithelial cell-cell adhesion [GO:0090136]; Golgi organization [GO:0007030]; microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]; zonula adherens maintenance [GO:0045218]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; minus-end-directed microtubule motor activity [GO:0008569]	centrosome [GO:0005813]; cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794]; kinesin complex [GO:0005871]; microtubule cytoskeleton [GO:0015630]; zonula adherens [GO:0005915]	GO:0005524; GO:0005794; GO:0005813; GO:0005871; GO:0005915; GO:0007017; GO:0007018; GO:0007030; GO:0008017; GO:0008569; GO:0015630; GO:0030659; GO:0042802; GO:0045218; GO:0090136
GN005952	GN005952.1	Q3U145	44.3	228	348	381	4.79e-52	179	TMM64_MOUSE	Transmembrane protein 64	Mus musculus (Mouse)	negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of bone resorption [GO:0045780]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of osteoclast differentiation [GO:0045672]; regulation of ATP-dependent activity [GO:0043462]; regulation of cytosolic calcium ion concentration [GO:0051480]		endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	GO:0005783; GO:0016020; GO:0043462; GO:0045600; GO:0045668; GO:0045672; GO:0045780; GO:0051480; GO:0090090
GN005957	GN005957.1	Q3SZD7	55.1	274	276	277	1.83e-106	313	CBR1_BOVIN	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)	Bos taurus (Bovine)	vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH dehydrogenase (quinone) activity [GO:0008753]; prostaglandin E2 9-reductase activity [GO:0050221]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163]	cytoplasm [GO:0005737]	GO:0004090; GO:0005737; GO:0006805; GO:0008106; GO:0008753; GO:0042373; GO:0047020; GO:0047021; GO:0050221; GO:0160163
GN005958	GN005958.1	Q3SZD7	54.7	274	276	277	1.05e-105	311	CBR1_BOVIN	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)	Bos taurus (Bovine)	vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH dehydrogenase (quinone) activity [GO:0008753]; prostaglandin E2 9-reductase activity [GO:0050221]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163]	cytoplasm [GO:0005737]	GO:0004090; GO:0005737; GO:0006805; GO:0008106; GO:0008753; GO:0042373; GO:0047020; GO:0047021; GO:0050221; GO:0160163
GN005959	GN005959.1	G5EFC3	29.1	447	455	558	5.21e-55	195	KCNAG_CAEEL	Potassium voltage-gated channel protein egl-36 (Egg-laying defective protein 36)	Caenorhabditis elegans	action potential [GO:0001508]; monoatomic ion transmembrane transport [GO:0034220]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic ion channel activity [GO:0005244]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005244; GO:0005251; GO:0008076; GO:0016020; GO:0032590; GO:0032809; GO:0034220; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN005961	GN005961.1	P0AFQ9	29.5	210	638	265	2.20e-12	71.2	YCFH_ECO57	Uncharacterized metal-dependent hydrolase YcfH (EC 3.1.-.-)	Escherichia coli O157:H7		DNA nuclease activity [GO:0004536]; hydrolase activity, acting on ester bonds [GO:0016788]	cytosol [GO:0005829]	GO:0004536; GO:0005829; GO:0016788
GN005962	GN005962.1	Q3SZD7	54.6	262	270	277	5.33e-97	288	CBR1_BOVIN	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)	Bos taurus (Bovine)	vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH dehydrogenase (quinone) activity [GO:0008753]; prostaglandin E2 9-reductase activity [GO:0050221]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163]	cytoplasm [GO:0005737]	GO:0004090; GO:0005737; GO:0006805; GO:0008106; GO:0008753; GO:0042373; GO:0047020; GO:0047021; GO:0050221; GO:0160163
GN005963	GN005963.1	Q3SZD7	55.0	262	270	277	3.76e-97	289	CBR1_BOVIN	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)	Bos taurus (Bovine)	vitamin K metabolic process [GO:0042373]; xenobiotic metabolic process [GO:0006805]	15-hydroxyprostaglandin dehydrogenase (NADP+) activity [GO:0047021]; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO:0047020]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH dehydrogenase (quinone) activity [GO:0008753]; prostaglandin E2 9-reductase activity [GO:0050221]; S-nitrosoglutathione reductase (NADPH) activity [GO:0160163]	cytoplasm [GO:0005737]	GO:0004090; GO:0005737; GO:0006805; GO:0008106; GO:0008753; GO:0042373; GO:0047020; GO:0047021; GO:0050221; GO:0160163
GN005968	GN005968.1	O16374	28.8	125	298	425	5.54e-11	66.2	GALT1_CAEEL	Beta-1,4-galactosyltransferase galt-1 (EC 2.4.1.-)	Caenorhabditis elegans	carbohydrate derivative biosynthetic process [GO:1901137]; N-glycan processing [GO:0006491]	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; UDP-galactosyltransferase activity [GO:0035250]	Golgi cisterna membrane [GO:0032580]	GO:0003831; GO:0006491; GO:0032580; GO:0035250; GO:1901137
GN005969	GN005969.1	Q05858	27.9	419	1695	1213	2.13e-36	154	FMN_CHICK	Formin (Limb deformity protein)	Gallus gallus (Chicken)	actin nucleation [GO:0045010]; formin-nucleated actin cable assembly [GO:0070649]	actin binding [GO:0003779]; microtubule binding [GO:0008017]	actin filament [GO:0005884]; endoplasmic reticulum membrane [GO:0005789]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]	GO:0003779; GO:0005634; GO:0005789; GO:0005884; GO:0008017; GO:0015630; GO:0045010; GO:0070649
GN005974	GN005974.1	Q03041	39.1	266	355	663	6.48e-50	180	CNGA2_BOVIN	Cyclic nucleotide-gated channel alpha-2 (CNG channel alpha-2) (CNG-2) (CNG2) (Cyclic nucleotide-gated channel alpha 3) (CNCalpha3) (CNGa3) (Olfactory cyclic nucleotide-gated channel subunit 1) (OCNC1)	Bos taurus (Bovine)	calcium ion transport [GO:0006816]; monoatomic cation transmembrane transport [GO:0098655]; potassium ion transport [GO:0006813]; response to hydrogen sulfide [GO:1904880]; sensory perception of chemical stimulus [GO:0007606]; sensory perception of smell [GO:0007608]; sodium ion transport [GO:0006814]	cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; monoatomic ion channel activity [GO:0005216]	intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; non-motile cilium membrane [GO:0098804]; plasma membrane [GO:0005886]	GO:0005216; GO:0005222; GO:0005223; GO:0005886; GO:0006813; GO:0006814; GO:0006816; GO:0007606; GO:0007608; GO:0017071; GO:0030553; GO:0098655; GO:0098804; GO:1904880
GN005975	GN005975.1	Q2TA16	47.3	463	501	498	1.22e-129	389	DRC2_BOVIN	Dynein regulatory complex subunit 2 (Coiled-coil domain-containing protein 65)	Bos taurus (Bovine)	axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285]; regulation of cilium movement [GO:0003352]		axonemal dynein complex [GO:0005858]; axoneme [GO:0005930]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514]	GO:0003352; GO:0005858; GO:0005930; GO:0031514; GO:0036064; GO:0060285; GO:0070286
GN005976	GN005976.1	P91953	42.2	211	220	591	9.75e-41	149	HE_HEMPU	50 kDa hatching enzyme (HE) (HEZ) (EC 3.4.24.12) (Envelysin) (Sea-urchin-hatching proteinase) [Cleaved into: 38 kDa hatching enzyme; 32 kDa hatching enzyme non-specific; 15 kDa peptide]	Hemicentrotus pulcherrimus (Sea urchin) (Strongylocentrotus pulcherrimus)	collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]	GO:0004222; GO:0006508; GO:0008270; GO:0030198; GO:0030574; GO:0031012
GN005977	GN005977.1	Q5RDE7	72.6	402	370	457	1.68e-212	592	NFS1_PONAB	Cysteine desulfurase (EC 2.8.1.7)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	[2Fe-2S] cluster assembly [GO:0044571]; [4Fe-4S] cluster assembly [GO:0044572]	cysteine desulfurase activity [GO:0031071]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]	centrosome [GO:0005813]; cytosol [GO:0005829]; mitochondrial [2Fe-2S] assembly complex [GO:0099128]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005739; GO:0005813; GO:0005829; GO:0030170; GO:0031071; GO:0042803; GO:0044571; GO:0044572; GO:0099128
GN005978	GN005978.1	Q969N2	45.4	513	573	578	3.60e-152	452	PIGT_HUMAN	GPI-anchor transamidase component PIGT (Phosphatidylinositol-glycan biosynthesis class T protein)	Homo sapiens (Human)	attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; GPI anchored protein biosynthesis [GO:0180046]	GPI anchor binding [GO:0034235]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; membrane [GO:0016020]	GO:0005789; GO:0006506; GO:0016020; GO:0016255; GO:0031410; GO:0034235; GO:0042765; GO:0180046
GN005979	GN005979.1	P07686	45.4	449	992	556	1.79e-132	414	HEXB_HUMAN	Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]	Homo sapiens (Human)	astrocyte cell migration [GO:0043615]; carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan catabolic process [GO:0030207]; dermatan sulfate proteoglycan catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; N-acetylglucosamine metabolic process [GO:0006044]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell shape [GO:0008360]; single fertilization [GO:0007338]	acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylglucosaminidase activity [GO:0016231]; beta-N-acetylhexosaminidase activity [GO:0004563]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; beta-N-acetylhexosaminidase complex [GO:1905379]; cortical granule [GO:0060473]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]	GO:0001669; GO:0004563; GO:0005576; GO:0005764; GO:0005975; GO:0006044; GO:0006689; GO:0007338; GO:0008360; GO:0008375; GO:0016020; GO:0016231; GO:0030203; GO:0030207; GO:0030209; GO:0030214; GO:0030246; GO:0035578; GO:0042582; GO:0042802; GO:0043202; GO:0043615; GO:0044877; GO:0045944; GO:0060473; GO:0070062; GO:1905379
GN005980	GN005980.1	Q6GLJ1	28.0	243	504	470	3.35e-28	120	BTBDH_XENLA	BTB/POZ domain-containing protein 17	Xenopus laevis (African clawed frog)			extracellular region [GO:0005576]	GO:0005576
GN005981	GN005981.1	Q6DE14	77.8	45	101	375	3.14e-18	80.9	E2F4_XENLA	Transcription factor E2F4 (E2F-4)	Xenopus laevis (African clawed frog)	centriole assembly [GO:0098534]; motile cilium assembly [GO:0044458]; multi-ciliated epithelial cell differentiation [GO:1903251]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000978; GO:0000981; GO:0003700; GO:0005634; GO:0006357; GO:0044458; GO:0045944; GO:0046983; GO:0090575; GO:0098534; GO:1903251
GN005985	GN005985.1	P86856	48.0	204	345	321	3.02e-58	194	MANL_MYTCA	Nacrein-like protein	Mytilus californianus (California mussel)	one-carbon metabolic process [GO:0006730]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0004089; GO:0005576; GO:0006730; GO:0008270
GN005988	GN005988.1	Q63615	63.7	601	610	597	6.17e-274	764	VP33A_RAT	Vacuolar protein sorting-associated protein 33A (r-vps33a)	Rattus norvegicus (Rat)	autophagosome maturation [GO:0097352]; autophagosome-lysosome fusion [GO:0061909]; developmental pigmentation [GO:0048066]; endosome to lysosome transport [GO:0008333]; lysosome localization [GO:0032418]; melanosome localization [GO:0032400]; pigmentation [GO:0043473]; platelet formation [GO:0030220]; regulation of developmental pigmentation [GO:0048070]; vesicle-mediated transport [GO:0016192]	protein-containing complex binding [GO:0044877]	AP-3 adaptor complex [GO:0030123]; autophagosome [GO:0005776]; clathrin complex [GO:0071439]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]	GO:0005764; GO:0005765; GO:0005769; GO:0005770; GO:0005776; GO:0008333; GO:0016192; GO:0030123; GO:0030136; GO:0030220; GO:0030897; GO:0031410; GO:0031902; GO:0032400; GO:0032418; GO:0033263; GO:0043473; GO:0044877; GO:0048066; GO:0048070; GO:0048471; GO:0061909; GO:0071439; GO:0097352
GN005989	GN005989.1	Q95L73	51.7	116	152	191	2.41e-25	98.6	CY24A_BISBI	Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox)	Bison bison (American bison) (Bos bison)	innate immune response [GO:0045087]	heme binding [GO:0020037]	NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]	GO:0005886; GO:0020037; GO:0043020; GO:0045087
GN005990	GN005990.1	O95427	48.8	855	845	931	8.15e-266	765	PIGN_HUMAN	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (GPI-ethanolamine transferase I) (GPI-ETI) (MCD4 homolog) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N)	Homo sapiens (Human)	GPI anchor biosynthetic process [GO:0006506]	mannose-ethanolamine phosphotransferase activity [GO:0051377]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005789; GO:0005829; GO:0005886; GO:0006506; GO:0016020; GO:0051377
GN005996	GN005996.1	F4JTS8	25.0	2284	3097	2729	6.99e-137	486	NOV_ARATH	Protein NO VEIN (Protein EMBRYO DEFECTIVE 2597)	Arabidopsis thaliana (Mouse-ear cress)	auxin polar transport [GO:0009926]; cell fate specification [GO:0001708]; embryo development ending in seed dormancy [GO:0009793]; leaf vascular tissue pattern formation [GO:0010305]; root development [GO:0048364]; stem cell population maintenance [GO:0019827]		nucleus [GO:0005634]	GO:0001708; GO:0005634; GO:0009793; GO:0009926; GO:0010305; GO:0019827; GO:0048364
GN005998	GN005998.1	Q5PPM5	40.8	103	2309	267	4.62e-11	69.3	HES1_XENTR	Transcription factor HES-1 (Hairy and enhancer of split 1) (Protein hairy-1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	anterior/posterior pattern specification [GO:0009952]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of muscle organ development [GO:0048635]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; regulation of neurogenesis [GO:0050767]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0005634; GO:0007219; GO:0009952; GO:0043425; GO:0045665; GO:0045892; GO:0046982; GO:0048635; GO:0050767
GN005999	GN005999.1	Q3ZBG4	57.6	125	420	280	1.82e-38	143	HES1_BOVIN	Transcription factor HES-1 (Hairy and enhancer of split 1)	Bos taurus (Bovine)	anterior/posterior pattern specification [GO:0009952]; forebrain radial glial cell differentiation [GO:0021861]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of forebrain neuron differentiation [GO:2000978]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of DNA binding [GO:0043388]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein-containing complex assembly [GO:0065003]; regulation of neurogenesis [GO:0050767]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; N-box binding [GO:0071820]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000122; GO:0000981; GO:0001227; GO:0005634; GO:0007219; GO:0009952; GO:0021861; GO:0042531; GO:0042803; GO:0043388; GO:0043565; GO:0045665; GO:0045892; GO:0046425; GO:0046427; GO:0048711; GO:0048715; GO:0050767; GO:0060253; GO:0065003; GO:0070888; GO:0071820; GO:2000974; GO:2000978
GN006003	GN006003.1	Q28F51	54.7	371	457	409	3.95e-129	382	TADBP_XENTR	TAR DNA-binding protein 43 (TDP-43)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of protein stability [GO:0031647]; RNA splicing [GO:0008380]	double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0003690; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0008380; GO:0010468; GO:0010494; GO:0031647; GO:0042752
GN006011	GN006011.1	A1BQQ5	37.1	275	300	289	4.15e-53	178	MR30_CONMR	Cysteine-rich venom protein Mr30 (CRVP) (Cysteine-rich secretory protein Mr30) (GlaCrisp form 1/2/3) (Mr30-1/2)	Conus marmoreus (Marble cone)			extracellular region [GO:0005576]	GO:0005576
GN006012	GN006012.1	A1BQQ5	38.8	147	651	289	4.11e-16	82.8	MR30_CONMR	Cysteine-rich venom protein Mr30 (CRVP) (Cysteine-rich secretory protein Mr30) (GlaCrisp form 1/2/3) (Mr30-1/2)	Conus marmoreus (Marble cone)			extracellular region [GO:0005576]	GO:0005576
GN006013	GN006013.1	Q7YT83	37.8	286	427	300	7.50e-55	187	TX31_CONTE	Cysteine-rich venom protein (CRVP) (EC 3.4.-.-) (Substrate-specific endoprotease Tex31)	Conus textile (Cloth-of-gold cone)			extracellular region [GO:0005576]	GO:0005576
GN006014	GN006014.1	Q5UCA8	31.9	119	189	178	1.24e-09	58.2	BRYP_PHYPA	Bryoporin (PpBP) (Physcomitrin)	Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens)	cytolysis in another organism [GO:0051715]; monoatomic cation transport [GO:0006812]; pore complex assembly [GO:0046931]	channel activity [GO:0015267]	pore complex [GO:0046930]	GO:0006812; GO:0015267; GO:0046930; GO:0046931; GO:0051715
GN006015	GN006015.1	P04988	42.4	125	200	343	3.25e-28	111	CYSP1_DICDI	Cysteine proteinase 1 (EC 3.4.22.-)	Dictyostelium discoideum (Social amoeba)	hyperosmotic response [GO:0006972]; proteolysis [GO:0006508]	cysteine-type peptidase activity [GO:0008234]	lysosome [GO:0005764]	GO:0005764; GO:0006508; GO:0006972; GO:0008234
GN006024	GN006024.1	P86860	33.9	271	2020	294	2.58e-41	158	PSM_MYTCA	Shell matrix protein	Mytilus californianus (California mussel)			extracellular region [GO:0005576]	GO:0005576
GN006026	GN006026.1	Q5XHB2	49.3	71	171	209	8.97e-16	74.7	DUS22_XENTR	Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cellular response to growth factor stimulus [GO:0071363]; negative regulation of cell adhesion [GO:0007162]; negative regulation of T cell receptor signaling pathway [GO:0050860]; signal transduction [GO:0007165]	protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004722; GO:0004725; GO:0005634; GO:0005737; GO:0007162; GO:0007165; GO:0050860; GO:0071363; GO:1990782
GN006029	GN006029.1	Q9D187	73.2	153	156	163	3.65e-75	224	CIA2B_MOUSE	Cytosolic iron-sulfur assembly component 2B (Mitotic spindle-associated MMXD complex subunit MIP18)	Mus musculus (Mouse)	chromosome segregation [GO:0007059]; protein maturation [GO:0051604]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic [4Fe-4S] assembly targeting complex [GO:0097361]; midbody [GO:0030496]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0005634; GO:0005654; GO:0005737; GO:0005819; GO:0005829; GO:0007059; GO:0030496; GO:0051604; GO:0071817; GO:0097361
GN006031	GN006031.1	A2RT91	24.3	707	711	1465	2.84e-53	202	ANKAR_MOUSE	Ankyrin and armadillo repeat-containing protein	Mus musculus (Mouse)			membrane [GO:0016020]	GO:0016020
GN006032	GN006032.1	Q61140	26.5	1030	922	874	1.15e-68	249	BCAR1_MOUSE	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell receptor signaling pathway [GO:0050853]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to endothelin [GO:1990859]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to nitric oxide [GO:0071732]; endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; insulin receptor signaling pathway [GO:0008286]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell migration [GO:0010595]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; ruffle [GO:0001726]	GO:0001726; GO:0005737; GO:0005829; GO:0005925; GO:0007015; GO:0007169; GO:0007173; GO:0007186; GO:0007229; GO:0008286; GO:0010595; GO:0015629; GO:0016020; GO:0016477; GO:0019901; GO:0019904; GO:0030027; GO:0030036; GO:0030335; GO:0030424; GO:0035729; GO:0048008; GO:0048010; GO:0048011; GO:0048012; GO:0050851; GO:0050853; GO:0060326; GO:0071732; GO:0086100; GO:1900025; GO:1990859
GN006034	GN006034.1	F1QG30	29.1	539	462	545	9.13e-57	199	NSMA5_DANRE	Sphingomyelin phosphodiesterase 5 (EC 3.1.4.12) (Mitochondrial neutral sphingomyelinase) (mtnSMase)	Danio rerio (Zebrafish) (Brachydanio rerio)	ceramide biosynthetic process [GO:0046513]; glycosphingolipid metabolic process [GO:0006687]; sphingomyelin catabolic process [GO:0006685]; sphingomyelin metabolic process [GO:0006684]	glycerophospholipase activity [GO:0004620]; sphingomyelin phosphodiesterase activity [GO:0004767]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]	GO:0004620; GO:0004767; GO:0005576; GO:0005737; GO:0005743; GO:0005758; GO:0005789; GO:0006684; GO:0006685; GO:0006687; GO:0031966; GO:0046513
GN006037	GN006037.1	Q16515	30.9	359	904	512	9.99e-39	155	ASIC2_HUMAN	Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG)	Homo sapiens (Human)	cellular response to acidic pH [GO:0071468]; cellular response to xenobiotic stimulus [GO:0071466]; regulation of postsynapse assembly [GO:0150052]; sensory perception of sour taste [GO:0050915]; sodium ion transmembrane transport [GO:0035725]	monoatomic ion-gated channel activity [GO:0022839]; pH-gated sodium channel activity [GO:0160125]	dendritic spine [GO:0043197]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	GO:0005886; GO:0022839; GO:0035725; GO:0043025; GO:0043197; GO:0050915; GO:0071466; GO:0071468; GO:0098839; GO:0150052; GO:0160125
GN006038	GN006038.1	Q8N2E2	22.4	821	1023	1590	1.16e-26	122	VWDE_HUMAN	von Willebrand factor D and EGF domain-containing protein	Homo sapiens (Human)		signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]	GO:0005102; GO:0005576; GO:0009986
GN006039	GN006039.1	Q8BXA7	38.1	1066	1738	1320	1.99e-144	484	PHLP2_MOUSE	PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; protein dephosphorylation [GO:0006470]	protein serine/threonine phosphatase activity [GO:0004722]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment membrane [GO:0042622]	GO:0001917; GO:0004722; GO:0005634; GO:0005737; GO:0005829; GO:0005929; GO:0006470; GO:0035556; GO:0042622; GO:0045171; GO:0072686
GN006042	GN006042.1	Q90837	49.4	362	777	478	7.92e-97	312	ERG_CHICK	Transcriptional regulator Erg	Gallus gallus (Chicken)	cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0006357; GO:0030154; GO:0043565
GN006043	GN006043.1	Q01414	71.9	178	262	173	9.85e-81	243	ERG_LYTVA	Transcriptional regulator ERG homolog	Lytechinus variegatus (Green sea urchin) (Echinus variegatus)	cell differentiation [GO:0030154]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0030154; GO:0043565
GN006046	GN006046.1	Q4ADK4	42.0	300	290	298	7.08e-47	162	CFDP1_MUNRE	Heterochromatin-stabilizing protein CFDP1 (Bucentaur) (Craniofacial development protein 1)	Muntiacus reevesi (Reeves' muntjac) (Cervus reevesi)			chromosome [GO:0005694]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]	GO:0000812; GO:0005634; GO:0005694
GN006049	GN006049.1	Q3UJB9	37.2	258	295	1406	1.08e-44	165	EDC4_MOUSE	Enhancer of mRNA-decapping protein 4	Mus musculus (Mouse)	deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]		cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]	GO:0000932; GO:0005634; GO:0005654; GO:0031087; GO:0036464
GN006054	GN006054.1	Q5NDE3	31.7	167	162	579	3.56e-19	86.7	PMGT2_TETNG	Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2) (EC 2.4.1.312) (Extracellular O-linked N-acetylglucosamine transferase-like) (Glycosyltransferase-like domain-containing protein 2)	Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)	neuron migration [GO:0001764]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via mannose [GO:0035269]	acetylglucosaminyltransferase activity [GO:0008375]; protein O-acetylglucosaminyltransferase activity [GO:0097363]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0001764; GO:0005783; GO:0005789; GO:0006493; GO:0008375; GO:0035269; GO:0097363
GN006055	GN006055.1	Q64449	47.9	71	266	1479	2.55e-13	73.2	MRC2_MOUSE	C-type mannose receptor 2 (Lectin lambda) (Macrophage mannose receptor 2) (CD antigen CD280)	Mus musculus (Mouse)	collagen catabolic process [GO:0030574]; receptor-mediated endocytosis [GO:0006898]	carbohydrate binding [GO:0030246]; collagen binding [GO:0005518]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	GO:0004888; GO:0005518; GO:0005886; GO:0006898; GO:0009986; GO:0030246; GO:0030574
GN006057	GN006057.1	Q80TB8	57.5	369	444	417	5.74e-153	443	VAT1L_MOUSE	Putative NADPH-dependent quinone oxidoreductase VAT1L (EC 1.6.5.5) (Synaptic vesicle membrane protein VAT-1 homolog-like) (Vesicle amine transport protein 1 like)	Mus musculus (Mouse)		NADPH dehydrogenase (quinone) activity [GO:0008753]; quinone reductase (NADPH) activity [GO:0003960]; zinc ion binding [GO:0008270]		GO:0003960; GO:0008270; GO:0008753
GN006058	GN006058.1	Q75QN2	34.4	1015	997	995	2.86e-165	514	INT8_HUMAN	Integrator complex subunit 8 (Int8) (Protein kaonashi-1)	Homo sapiens (Human)	protein localization to chromatin [GO:0071168]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; RNA polymerase II transcription initiation surveillance [GO:0160240]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]		chromatin [GO:0000785]; chromosome [GO:0005694]; INTAC complex [GO:0160232]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0005694; GO:0016180; GO:0032039; GO:0034243; GO:0034472; GO:0071168; GO:0160232; GO:0160240
GN006072	GN006072.1	Q9WIJ5	37.5	128	252	286	8.00e-24	100	MREP_FBNY1	Master replication protein (M-Rep) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase C2) (Replication-associated protein 2) (Rep2)	Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV)	DNA replication [GO:0006260]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleotidyltransferase activity [GO:0016779]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	host cell nucleus [GO:0042025]	GO:0003677; GO:0003723; GO:0003724; GO:0004519; GO:0005524; GO:0006260; GO:0016779; GO:0016887; GO:0042025; GO:0046872
GN006078	GN006078.1	Q9D305	35.5	110	124	217	5.83e-11	60.5	THAP2_MOUSE	THAP domain-containing protein 2	Mus musculus (Mouse)			nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730
GN006093	GN006093.1	Q5F2F2	35.7	350	376	459	3.49e-55	191	ABH15_MOUSE	Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15)	Mus musculus (Mouse)	adipose tissue development [GO:0060612]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]	monoacylglycerol lipase activity [GO:0047372]; short-chain carboxylesterase activity [GO:0034338]	extracellular region [GO:0005576]	GO:0005576; GO:0006629; GO:0016042; GO:0034338; GO:0047372; GO:0060612
GN006095	GN006095.1	Q54PZ6	24.3	288	560	702	5.64e-18	91.3	Y5897_DICDI	Putative uncharacterized protein DDB_G0284213	Dictyostelium discoideum (Social amoeba)	early endosome to late endosome transport [GO:0045022]	guanyl-nucleotide exchange factor activity [GO:0005085]; SNARE binding [GO:0000149]	early endosome [GO:0005769]; late endosome [GO:0005770]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; tubular endosome [GO:0097422]	GO:0000149; GO:0005085; GO:0005769; GO:0005770; GO:0005886; GO:0030133; GO:0045022; GO:0097422
GN006096	GN006096.1	G5EFC3	36.3	215	293	558	1.06e-35	137	KCNAG_CAEEL	Potassium voltage-gated channel protein egl-36 (Egg-laying defective protein 36)	Caenorhabditis elegans	action potential [GO:0001508]; monoatomic ion transmembrane transport [GO:0034220]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic ion channel activity [GO:0005244]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005244; GO:0005251; GO:0008076; GO:0016020; GO:0032590; GO:0032809; GO:0034220; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN006099	GN006099.1	Q3T0E7	93.0	329	328	330	9.12e-233	637	PP1A_BOVIN	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)	Bos taurus (Bovine)	circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000806]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein dephosphorylation [GO:0006470]; protein stabilization [GO:0050821]; regulation of circadian rhythm [GO:0042752]; RNA polymerase II promoter clearance [GO:0001111]; telomere maintenance in response to DNA damage [GO:0043247]	cadherin binding involved in cell-cell adhesion [GO:0098641]; iron ion binding [GO:0005506]; phosphatase activity [GO:0016791]; protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity [GO:0180007]; transition metal ion binding [GO:0046914]	adherens junction [GO:0005912]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; PTW/PP1 phosphatase complex [GO:0072357]	GO:0000781; GO:0001111; GO:0004722; GO:0005506; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005783; GO:0005829; GO:0005912; GO:0006470; GO:0014069; GO:0016791; GO:0032922; GO:0032968; GO:0034244; GO:0042752; GO:0043153; GO:0043247; GO:0045725; GO:0046914; GO:0050821; GO:0072357; GO:0098641; GO:0180007; GO:2000806
GN006101	GN006101.1	Q71W03	38.7	168	280	176	1.08e-28	110	Y2748_LISMF	Macro domain-containing protein LMOf2365_2748	Listeria monocytogenes serotype 4b (strain F2365)				
GN006102	GN006102.1	Q8N9I9	49.7	191	482	347	6.04e-57	195	DTX3_HUMAN	E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)	Homo sapiens (Human)	Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0007219; GO:0008593; GO:0016567; GO:0061630
GN006107	GN006107.1	Q9WTS8	45.6	125	134	335	2.84e-23	95.5	FCN1_RAT	Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)	Rattus norvegicus (Rat)	cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of interleukin-8 production [GO:0032757]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; pattern recognition receptor activity [GO:0038187]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]	GO:0001867; GO:0002752; GO:0003823; GO:0005102; GO:0005576; GO:0005886; GO:0007186; GO:0009986; GO:0031012; GO:0032757; GO:0033691; GO:0038187; GO:0097367; GO:0106139
GN006110	GN006110.1	Q5E9F9	93.1	433	433	433	1.11e-297	810	PRS7_BOVIN	26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2)	Bos taurus (Bovine)	ubiquitin-dependent protein catabolic process [GO:0006511]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]	GO:0000502; GO:0000932; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006511; GO:0016887; GO:0022624; GO:0036402
GN006112	GN006112.1	Q9NRA2	42.1	126	171	495	7.00e-28	111	S17A5_HUMAN	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)	Homo sapiens (Human)	carbohydrate derivative transport [GO:1901264]; monoatomic anion transport [GO:0006820]; neurotransmitter loading into synaptic vesicle [GO:0098700]; sialic acid transport [GO:0015739]	carbohydrate:proton symporter activity [GO:0005351]; D-glucuronate transmembrane transporter activity [GO:0042880]; glucuronate transmembrane transporter activity [GO:0015135]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	GO:0005351; GO:0005764; GO:0005765; GO:0005886; GO:0006820; GO:0015135; GO:0015136; GO:0015538; GO:0015739; GO:0016020; GO:0016323; GO:0016324; GO:0030672; GO:0042880; GO:0098700; GO:0098978; GO:1901264
GN006117	GN006117.1	Q8R3V6	27.9	513	571	388	3.82e-23	105	CUED1_MOUSE	CUE domain-containing protein 1	Mus musculus (Mouse)		ubiquitin binding [GO:0043130]		GO:0043130
GN006118	GN006118.1	Q9VUI3	32.9	949	1296	1076	8.20e-142	462	EMAL_DROME	Echinoderm microtubule-associated protein-like CG42247	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; cellular response to mechanical stimulus [GO:0071260]; intracellular signal transduction [GO:0035556]; melanotic encapsulation of foreign target [GO:0035011]; microtubule cytoskeleton organization [GO:0000226]; sensory perception of sound [GO:0007605]	microtubule binding [GO:0008017]; microtubule stabilizing activity [GO:0140778]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; sensory dendrite [GO:0071683]	GO:0000226; GO:0005829; GO:0005856; GO:0007605; GO:0008017; GO:0008344; GO:0035011; GO:0035556; GO:0071260; GO:0071683; GO:0140778
GN006120	GN006120.1	P40720	66.0	535	568	580	1.03e-264	738	FUMA_SALTY	Fumarate hydratase class I, aerobic (EC 4.2.1.2) (Fumarase A) (Oxaloacetate keto--enol-isomerase) (OAAKE isomerase) (Oxaloacetate tautomerase) (EC 5.3.2.2)	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	tricarboxylic acid cycle [GO:0006099]	4 iron, 4 sulfur cluster binding [GO:0051539]; fumarate hydratase activity [GO:0004333]; oxaloacetate tautomerase activity [GO:0050163]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]	GO:0004333; GO:0005829; GO:0006099; GO:0042803; GO:0050163; GO:0051539
GN006121	GN006121.1	O35130	75.5	204	228	244	3.32e-108	314	NEP1_MOUSE	Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.-) (18S rRNA (pseudouridine(1248)-N1)-methyltransferase) (18S rRNA Psi1248 methyltransferase) (Nucleolar protein EMG1 homolog) (Protein C2f) (Ribosome biogenesis protein NEP1)	Mus musculus (Mouse)	blastocyst development [GO:0001824]; nucleologenesis [GO:0017126]; ribosomal small subunit biogenesis [GO:0042274]; rRNA base methylation [GO:0070475]	identical protein binding [GO:0042802]; rRNA (pseudouridine) methyltransferase activity [GO:0070037]; rRNA binding [GO:0019843]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	GO:0001824; GO:0005654; GO:0005694; GO:0005730; GO:0017126; GO:0019843; GO:0032040; GO:0042274; GO:0042802; GO:0070037; GO:0070475
GN006122	GN006122.1	P42674	40.0	290	306	597	7.34e-59	201	BP10_PARLI	Blastula protease 10 (EC 3.4.24.-)	Paracentrotus lividus (Common sea urchin)	molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]	GO:0004222; GO:0005576; GO:0005938; GO:0006508; GO:0008270; GO:0018996; GO:0048471
GN006124	GN006124.1	A9UUB8	40.7	300	302	333	2.32e-64	208	FUCT1_MONBE	GDP-fucose transporter 1 (Solute carrier family 35 member C1 homolog)	Monosiga brevicollis (Choanoflagellate)	GDP-fucose import into Golgi lumen [GO:0036085]	GDP-fucose transmembrane transporter activity [GO:0005457]	Golgi membrane [GO:0000139]	GO:0000139; GO:0005457; GO:0036085
GN006125	GN006125.1	P42575	39.9	313	654	452	4.63e-54	194	CASP2_HUMAN	Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]	Homo sapiens (Human)	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; luteolysis [GO:0001554]; negative regulation of apoptotic process [GO:0043066]; neural retina development [GO:0003407]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]	cysteine-type endopeptidase activity [GO:0004197]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endopeptidase complex [GO:1905369]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0001554; GO:0003407; GO:0004197; GO:0005634; GO:0005730; GO:0005737; GO:0005739; GO:0005829; GO:0006915; GO:0006974; GO:0008630; GO:0016485; GO:0019899; GO:0019904; GO:0030330; GO:0042802; GO:0043065; GO:0043066; GO:0043525; GO:0071260; GO:0097190; GO:0097192; GO:0097194; GO:1905369
GN006126	GN006126.1	Q9UHV7	34.1	2078	1803	2174	8.11e-269	843	MED13_HUMAN	Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)	Homo sapiens (Human)	cholesterol homeostasis [GO:0042632]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; triglyceride homeostasis [GO:0070328]	nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	CKM complex [GO:1990508]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0003712; GO:0003713; GO:0005634; GO:0005654; GO:0016020; GO:0016592; GO:0042632; GO:0042809; GO:0045893; GO:0045944; GO:0046966; GO:0060261; GO:0070328; GO:1990508
GN006127	GN006127.1	Q5SWW4	48.5	227	233	2171	1.03e-62	214	MED13_MOUSE	Mediator of RNA polymerase II transcription subunit 13 (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240)	Mus musculus (Mouse)	cholesterol homeostasis [GO:0042632]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; triglyceride homeostasis [GO:0070328]	nuclear thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	CKM complex [GO:1990508]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0003712; GO:0003713; GO:0005634; GO:0005654; GO:0016592; GO:0042632; GO:0045893; GO:0045944; GO:0046966; GO:0060261; GO:0070328; GO:1990508
GN006129	GN006129.1	Q4KLI9	21.8	545	471	569	3.15e-22	103	FBXW5_RAT	F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)	Rattus norvegicus (Rat)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	protein kinase binding [GO:0019901]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005737; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0080008
GN006130	GN006130.1	F7H9X2	27.6	322	551	744	6.89e-29	125	TRIM2_CALJA	Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2)	Callithrix jacchus (White-tufted-ear marmoset) (Simia Jacchus)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0043161; GO:0043523; GO:0061630
GN006131	GN006131.1	Q18120	29.4	309	353	461	5.81e-26	111	TWK18_CAEEL	TWiK family of potassium channels protein 18	Caenorhabditis elegans	locomotion [GO:0040011]; muscle contraction [GO:0006936]; potassium ion transport [GO:0006813]	outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0006813; GO:0006936; GO:0015271; GO:0016020; GO:0022841; GO:0040011
GN006132	GN006132.1	Q2KHM9	25.9	1009	1016	967	7.51e-39	160	MOONR_HUMAN	Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein)	Homo sapiens (Human)	centriole replication [GO:0007099]; cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; protein localization to centrosome [GO:0071539]		centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; microtubule organizing center [GO:0005815]	GO:0005813; GO:0005814; GO:0005815; GO:0007099; GO:0034451; GO:0060271; GO:0061824; GO:0071539
GN006135	GN006135.1	P48548	40.1	327	517	419	2.08e-82	265	KCNJ5_RAT	G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)	Rattus norvegicus (Rat)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]	external side of plasma membrane [GO:0009897]; inward rectifier potassium channel complex [GO:1902937]; membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]	GO:0005242; GO:0005886; GO:0008076; GO:0009897; GO:0015467; GO:0016020; GO:0030315; GO:0071805; GO:0086089; GO:0086091; GO:0098914; GO:1902937; GO:1990573
GN006136	GN006136.1	P48545	37.9	367	447	419	3.01e-82	262	KCNJ5_MOUSE	G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)	Mus musculus (Mouse)	membrane repolarization during atrial cardiac muscle cell action potential [GO:0098914]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]	G-protein activated inward rectifier potassium channel activity [GO:0015467]; inward rectifier potassium channel activity [GO:0005242]; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:0086089]	external side of plasma membrane [GO:0009897]; inward rectifier potassium channel complex [GO:1902937]; membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; voltage-gated potassium channel complex [GO:0008076]	GO:0005242; GO:0005886; GO:0008076; GO:0009897; GO:0015467; GO:0016020; GO:0030315; GO:0071805; GO:0086089; GO:0086091; GO:0098914; GO:1902937; GO:1990573
GN006138	GN006138.1	A8TX70	26.9	227	321	2615	2.42e-16	83.6	CO6A5_HUMAN	Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4)	Homo sapiens (Human)	extracellular matrix organization [GO:0030198]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005589; GO:0030020; GO:0030198; GO:0031012
GN006144	GN006144.1	P46197	51.2	246	653	1047	1.40e-70	251	ANPRB_BOVIN	Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B)	Bos taurus (Bovine)	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; identical protein binding [GO:0042802]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; protein kinase activity [GO:0004672]	plasma membrane [GO:0005886]	GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0006182; GO:0007168; GO:0016941; GO:0017046; GO:0035556; GO:0042802
GN006148	GN006148.1	Q9FGH2	29.7	145	357	182	4.80e-10	61.6	LSH5_ARATH	Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 5 (Protein ORGAN BOUNDARY 5)	Arabidopsis thaliana (Mouse-ear cress)	mRNA transcription [GO:0009299]; post-embryonic plant morphogenesis [GO:0090698]		nucleus [GO:0005634]	GO:0005634; GO:0009299; GO:0090698
GN006172	GN006172.1	Q9UJX3	42.8	563	553	565	1.69e-138	416	APC7_HUMAN	Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7)	Homo sapiens (Human)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; brain development [GO:0007420]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	enzyme-substrate adaptor activity [GO:0140767]; protein phosphatase binding [GO:0019903]	anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0000792; GO:0005634; GO:0005654; GO:0005680; GO:0005819; GO:0005829; GO:0007346; GO:0007420; GO:0015630; GO:0016567; GO:0019903; GO:0031145; GO:0045171; GO:0045842; GO:0051301; GO:0051445; GO:0070936; GO:0070979; GO:0072686; GO:0140767; GO:0141198
GN006173	GN006173.1	Q9BY10	24.2	409	506	475	1.25e-19	95.1	S46A2_HUMAN	Solute carrier family 46 member 2 (Thymic stromal cotransporter homolog)	Homo sapiens (Human)	cyclic-GMP-AMP transmembrane import across plasma membrane [GO:0140361]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; transmembrane transport [GO:0055085]	cyclic-GMP-AMP transmembrane transporter activity [GO:0140360]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]	cell surface [GO:0009986]; endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0009986; GO:0010008; GO:0015293; GO:0016020; GO:0022857; GO:0055085; GO:0070430; GO:0140360; GO:0140361
GN006174	GN006174.1	A0AUT1	42.5	414	498	499	2.32e-71	238	TCHP_XENLA	Trichoplein keratin filament-binding protein (Protein TCHP)	Xenopus laevis (African clawed frog)	apoptotic process [GO:0006915]		centrosome [GO:0005813]; keratin filament [GO:0045095]	GO:0005813; GO:0006915; GO:0045095
GN006177	GN006177.1	Q5ZI89	51.7	1125	1079	1132	0.0	1100	TPC11_CHICK	Trafficking protein particle complex subunit 11	Gallus gallus (Chicken)			Golgi apparatus [GO:0005794]	GO:0005794
GN006179	GN006179.1	Q6NVR9	59.0	442	442	594	3.60e-158	462	ATAD3_XENTR	ATPase family AAA domain-containing protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mitochondrion organization [GO:0007005]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	GO:0005524; GO:0005739; GO:0005743; GO:0007005; GO:0016887; GO:0042645
GN006187	GN006187.1	Q9H611	36.9	141	201	641	7.04e-14	72.8	PIF1_HUMAN	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein)	Homo sapiens (Human)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; negative regulation of telomere maintenance via telomerase [GO:0032211]; protein-DNA-RNA complex disassembly [GO:0001117]; telomere maintenance via telomerase [GO:0007004]	5'-3' DNA helicase activity [GO:0043139]; 5'-3' DNA/RNA helicase activity [GO:0033678]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex unwinding activity [GO:0160225]; magnesium ion binding [GO:0000287]; single-stranded DNA helicase activity [GO:0017116]; telomerase inhibitor activity [GO:0010521]; telomeric repeat DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000781; GO:0001117; GO:0005524; GO:0005634; GO:0005654; GO:0005739; GO:0006281; GO:0006310; GO:0007004; GO:0010521; GO:0016887; GO:0017116; GO:0032211; GO:0033678; GO:0042162; GO:0042645; GO:0043139; GO:0051880; GO:0160225
GN006188	GN006188.1	Q5AXT5	34.8	233	289	745	1.05e-31	127	PIF1_EMENI	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]	GO:0000723; GO:0003697; GO:0005524; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0043139; GO:0043596; GO:0071932
GN006195	GN006195.1	Q5UPX0	38.8	103	149	548	1.65e-12	67.0	YR290_MIMIV	Putative ATP-dependent RNA helicase R290 (EC 3.6.4.13)	Acanthamoeba polyphaga mimivirus (APMV)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]		GO:0003676; GO:0003724; GO:0005524; GO:0006260; GO:0006281; GO:0006310; GO:0016887; GO:0043138
GN006197	GN006197.1	A4WFX9	31.9	191	835	260	2.16e-12	71.6	TATD_ENT38	3'-5' ssDNA/RNA exonuclease TatD (EC 3.1.11.-) (EC 3.1.13.-) (DNase TatD)	Enterobacter sp. (strain 638)		3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]	cytosol [GO:0005829]	GO:0000175; GO:0000287; GO:0005829; GO:0008310
GN006200	GN006200.1	P97714	36.9	122	141	562	5.66e-16	76.6	ADA1D_MOUSE	Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor)	Mus musculus (Mouse)	adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; cell-cell signaling [GO:0007267]; negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure [GO:0001986]; neuron-glial cell signaling [GO:0150099]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of vasoconstriction [GO:0045907]; regulation of blood pressure [GO:0008217]	alpha1-adrenergic receptor activity [GO:0004937]; identical protein binding [GO:0042802]	plasma membrane [GO:0005886]	GO:0001986; GO:0001994; GO:0004937; GO:0005886; GO:0007200; GO:0007204; GO:0007267; GO:0008217; GO:0042802; GO:0043410; GO:0045907; GO:0071880; GO:0150099
GN006210	GN006210.1	P9WEL6	24.4	295	345	308	6.87e-18	86.3	AVAO_ASPVE	Ava biosynthesis cluster protein O	Aspergillus versicolor				
GN006214	GN006214.1	O95407	26.8	179	419	300	1.24e-12	71.6	TNF6B_HUMAN	Tumor necrosis factor receptor superfamily member 6B (Decoy receptor 3) (DcR3) (Decoy receptor for Fas ligand) (M68)	Homo sapiens (Human)	negative regulation of apoptotic process [GO:0043066]; negative regulation of inflammatory response [GO:0050728]	receptor decoy activity [GO:0140319]	decoy receptor complex [GO:0140368]; extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020; GO:0043066; GO:0050728; GO:0140319; GO:0140368
GN006215	GN006215.1	Q5EAR6	29.2	195	190	206	1.29e-17	80.1	VMA22_DANRE	Vacuolar ATPase assembly protein VMA22 (Coiled-coil domain-containing protein 115)	Danio rerio (Zebrafish) (Brachydanio rerio)	intracellular iron ion homeostasis [GO:0006879]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]		COPI-coated vesicle [GO:0030137]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome [GO:0005768]; lysosome [GO:0005764]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]	GO:0005764; GO:0005768; GO:0005783; GO:0005793; GO:0006879; GO:0016471; GO:0030137; GO:0070072
GN006218	GN006218.1	Q5RCR5	50.7	272	345	301	1.60e-93	283	SUMF2_PONAB	Inactive C-alpha-formylglycine-generating enzyme 2 (Sulfatase-modifying factor 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)		identical protein binding [GO:0042802]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	GO:0005783; GO:0005788; GO:0042802
GN006219	GN006219.1	P21872	59.0	1005	999	1003	0.0	1153	PUR2_CHICK	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]	Gallus gallus (Chicken)	'de novo' IMP biosynthetic process [GO:0006189]; adenine biosynthetic process [GO:0046084]; purine nucleotide biosynthetic process [GO:0006164]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylamine-glycine ligase activity [GO:0004637]; phosphoribosylformylglycinamidine cyclo-ligase activity [GO:0004641]; phosphoribosylglycinamide formyltransferase activity [GO:0004644]	cytosol [GO:0005829]	GO:0004637; GO:0004641; GO:0004644; GO:0005524; GO:0005829; GO:0006164; GO:0006189; GO:0046084; GO:0046872
GN006220	GN006220.1	Q8K2A8	61.3	93	102	438	7.03e-31	115	ALG3_MOUSE	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Asparagine-linked glycosylation protein 3 homolog) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase) (Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase) (Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase)	Mus musculus (Mouse)	dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]	dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0052925]	endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0006487; GO:0006488; GO:0052925
GN006221	GN006221.1	Q92685	52.7	311	331	438	2.73e-105	318	ALG3_HUMAN	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Asparagine-linked glycosylation protein 3 homolog) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase) (Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase) (Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase) (Not56-like protein)	Homo sapiens (Human)	dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]	alpha-1,3-mannosyltransferase activity [GO:0000033]; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0052925]	endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553]	GO:0000033; GO:0005789; GO:0006487; GO:0006488; GO:0052925; GO:0098553
GN006230	GN006230.1	Q9VE46	46.8	425	506	614	2.45e-122	374	SC5A7_DROME	High-affinity choline transporter 1	Drosophila melanogaster (Fruit fly)	acetylcholine biosynthetic process [GO:0008292]; amino acid transmembrane transport [GO:0003333]; choline transport [GO:0015871]	amino acid transmembrane transporter activity [GO:0015171]; choline transmembrane transporter activity [GO:0015220]; choline:sodium symporter activity [GO:0005307]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0003333; GO:0005307; GO:0005886; GO:0008292; GO:0015171; GO:0015220; GO:0015871; GO:0016020
GN006231	GN006231.1	Q9VE46	47.8	490	527	614	1.55e-144	432	SC5A7_DROME	High-affinity choline transporter 1	Drosophila melanogaster (Fruit fly)	acetylcholine biosynthetic process [GO:0008292]; amino acid transmembrane transport [GO:0003333]; choline transport [GO:0015871]	amino acid transmembrane transporter activity [GO:0015171]; choline transmembrane transporter activity [GO:0015220]; choline:sodium symporter activity [GO:0005307]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0003333; GO:0005307; GO:0005886; GO:0008292; GO:0015171; GO:0015220; GO:0015871; GO:0016020
GN006233	GN006233.1	Q9NWY4	50.3	308	421	346	7.65e-104	314	HPF1_HUMAN	Histone PARylation factor 1	Homo sapiens (Human)	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; regulation of protein ADP-ribosylation [GO:0010835]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; poly-ADP-D-ribose binding [GO:0072572]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0000785; GO:0003682; GO:0005634; GO:0005694; GO:0006281; GO:0006302; GO:0006974; GO:0010835; GO:0042393; GO:0072572; GO:0090734; GO:0140768; GO:0140861
GN006235	GN006235.1	Q8WYN3	48.1	283	593	585	9.08e-71	241	CSRN3_HUMAN	Cysteine/serine-rich nuclear protein 3 (CSRNP-3) (Protein FAM130A2) (TGF-beta-induced apoptosis protein 2) (TAIP-2)	Homo sapiens (Human)	positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000981; GO:0001228; GO:0003700; GO:0005634; GO:0006357; GO:0043065; GO:0043565; GO:0045944
GN006236	GN006236.1	Q5R5J4	63.7	844	841	832	0.0	1015	VPS53_PONAB	Vacuolar protein sorting-associated protein 53 homolog	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	endocytic recycling [GO:0032456]; protein targeting to lysosome [GO:0006622]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle-mediated cholesterol transport [GO:0090119]		cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]	GO:0000938; GO:0005829; GO:0006622; GO:0010008; GO:0032456; GO:0042147; GO:0048471; GO:0055037; GO:0090119; GO:1990745
GN006237	GN006237.1	Q6AX60	50.3	606	604	849	1.49e-197	578	PTHB1_XENLA	Protein PTHB1 (Bardet-Biedl syndrome 9 protein homolog) (Parathyroid hormone-responsive B1 gene protein homolog)	Xenopus laevis (African clawed frog)	cilium assembly [GO:0060271]		BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; membrane [GO:0016020]	GO:0005929; GO:0016020; GO:0034451; GO:0034464; GO:0060170; GO:0060271
GN006238	GN006238.1	Q3SYG4	50.2	217	334	887	1.59e-64	222	PTHB1_HUMAN	Protein PTHB1 (Bardet-Biedl syndrome 9 protein) (Parathyroid hormone-responsive B1 gene protein)	Homo sapiens (Human)	cilium assembly [GO:0060271]; fat cell differentiation [GO:0045444]; protein localization to cilium [GO:0061512]		BBSome [GO:0034464]; centriolar satellite [GO:0034451]; ciliary membrane [GO:0060170]; ciliary tip [GO:0097542]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; membrane [GO:0016020]; pericentriolar material [GO:0000242]	GO:0000242; GO:0005829; GO:0005929; GO:0016020; GO:0034451; GO:0034464; GO:0035869; GO:0045444; GO:0060170; GO:0060271; GO:0061512; GO:0097542
GN006243	GN006243.1	Q5E988	90.1	202	204	204	8.02e-126	356	RS5_BOVIN	Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed]	Bos taurus (Bovine)	ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic small ribosomal subunit [GO:0022627]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]	GO:0003735; GO:0005737; GO:0005840; GO:0006412; GO:0019843; GO:0022627; GO:0032040; GO:0042274
GN006244	GN006244.1	P98163	22.9	284	340	1984	2.05e-10	65.9	YL_DROME	Vitellogenin receptor Yl (Protein yolkless) (Yl)	Drosophila melanogaster (Fruit fly)		calcium ion binding [GO:0005509]; vitellogenin receptor activity [GO:0008196]	cell cortex [GO:0005938]; clathrin-coated vesicle membrane [GO:0030665]; coated vesicle [GO:0030135]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]	GO:0005509; GO:0005737; GO:0005886; GO:0005938; GO:0008196; GO:0030135; GO:0030665; GO:0031410; GO:0031901
GN006245	GN006245.1	Q8BK03	45.1	386	512	593	2.00e-96	306	MIGA2_MOUSE	Mitoguardin 2 (Protein FAM73B)	Mus musculus (Mouse)	bone development [GO:0060348]; mitochondrial fusion [GO:0008053]	protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]	GO:0005741; GO:0005829; GO:0005886; GO:0008053; GO:0042803; GO:0046982; GO:0060348
GN006247	GN006247.1	P49796	35.4	243	934	1198	3.01e-37	155	RGS3_HUMAN	Regulator of G protein signaling 3 (RGP3) (RGS3)	Homo sapiens (Human)	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0003924; GO:0005096; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0007186; GO:0008277
GN006248	GN006248.1	Q6P618	48.0	485	489	485	1.73e-170	492	KAD8_XENTR	Adenylate kinase 8 (AK 8) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 8)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		AMP kinase activity [GO:0004017]; ATP binding [GO:0005524]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]	9+2 motile cilium [GO:0097729]; cytosol [GO:0005829]	GO:0004017; GO:0004550; GO:0005524; GO:0005829; GO:0036431; GO:0097729
GN006249	GN006249.1	O57590	74.7	265	270	269	1.67e-141	401	SURF4_TAKRU	Surfeit locus protein 4	Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; lipid homeostasis [GO:0055088]; lipoprotein transport [GO:0042953]; regulation of lipid transport [GO:0032368]	cargo receptor activity [GO:0038024]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005789; GO:0006888; GO:0007030; GO:0032368; GO:0033116; GO:0038024; GO:0042953; GO:0055088
GN006250	GN006250.1	A6QR06	38.0	329	341	335	5.71e-54	183	TADA1_BOVIN	Transcriptional adapter 1 (Transcriptional adapter 1-like protein)	Bos taurus (Bovine)	regulation of transcription by RNA polymerase II [GO:0006357]	transcription coactivator activity [GO:0003713]	nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]	GO:0000124; GO:0003713; GO:0005654; GO:0006357
GN006251	GN006251.1	Q9BS26	52.8	373	1157	406	3.51e-119	377	ERP44_HUMAN	Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4)	Homo sapiens (Human)	cell redox homeostasis [GO:0045454]; glycoprotein metabolic process [GO:0009100]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]	protein disulfide isomerase activity [GO:0003756]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; specific granule lumen [GO:0035580]	GO:0003756; GO:0005576; GO:0005788; GO:0005789; GO:0005793; GO:0006457; GO:0006986; GO:0009100; GO:0009986; GO:0034976; GO:0035580; GO:0045454; GO:0070062
GN006252	GN006252.1	Q9NQV6	44.5	860	1962	1147	1.42e-84	307	PRD10_HUMAN	PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin)	Homo sapiens (Human)	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	GO:0000785; GO:0000976; GO:0003700; GO:0005634; GO:0005654; GO:0017053; GO:0045893; GO:0045944
GN006253	GN006253.1	Q14684	35.5	338	740	758	2.37e-51	194	RRP1B_HUMAN	Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)	Homo sapiens (Human)	cellular response to virus [GO:0098586]; host-mediated activation of viral transcription [GO:0043923]; negative regulation of GTPase activity [GO:0034260]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]; rRNA processing [GO:0006364]	RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	chromosome [GO:0005694]; cytosol [GO:0005829]; euchromatin [GO:0000791]; granular component [GO:0001652]; heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]	GO:0000791; GO:0000792; GO:0001652; GO:0003713; GO:0003723; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005829; GO:0006357; GO:0006364; GO:0030688; GO:0034260; GO:0043065; GO:0043484; GO:0043923; GO:0045944; GO:0098586
GN006255	GN006255.1	A2AX52	21.4	1317	1980	2309	1.37e-58	228	CO6A4_MOUSE	Collagen alpha-4(VI) chain	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]	collagen binding [GO:0005518]	collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991]	GO:0005518; GO:0005576; GO:0005589; GO:0030198; GO:0031012; GO:0032991
GN006256	GN006256.1	P15989	23.7	1921	2073	3137	5.09e-113	406	CO6A3_CHICK	Collagen alpha-3(VI) chain	Gallus gallus (Chicken)		serine-type endopeptidase inhibitor activity [GO:0004867]	collagen type VI trimer [GO:0005589]	GO:0004867; GO:0005589
GN006257	GN006257.1	P32018	31.1	132	170	1888	2.99e-13	70.1	COEA1_CHICK	Collagen alpha-1(XIV) chain (Undulin)	Gallus gallus (Chicken)	extracellular matrix organization [GO:0030198]		interstitial matrix [GO:0005614]	GO:0005614; GO:0030198
GN006258	GN006258.1	Q60847	35.7	129	131	3120	1.37e-21	92.4	COCA1_MOUSE	Collagen alpha-1(XII) chain	Mus musculus (Mouse)	endodermal cell differentiation [GO:0035987]		collagen type XII trimer [GO:0005595]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005595; GO:0031012; GO:0035987
GN006261	GN006261.1	Q8TBB0	33.6	110	169	222	5.59e-15	72.8	THAP6_HUMAN	THAP domain-containing protein 6	Homo sapiens (Human)			microtubule cytoskeleton [GO:0015630]	GO:0015630
GN006262	GN006262.1	P70211	30.1	146	1199	1447	7.98e-10	67.4	DCC_MOUSE	Netrin receptor DCC (Tumor suppressor protein DCC)	Mus musculus (Mouse)	anterior/posterior axon guidance [GO:0033564]; axon guidance [GO:0007411]; cell-cell adhesion [GO:0098609]; dorsal/ventral axon guidance [GO:0033563]; neuron migration [GO:0001764]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of neuron projection development [GO:0010976]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; spinal cord ventral commissure morphogenesis [GO:0021965]	identical protein binding [GO:0042802]; netrin receptor activity [GO:0005042]; transcription coactivator activity [GO:0003713]	axon [GO:0030424]; cell surface [GO:0009986]; growth cone membrane [GO:0032584]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0001764; GO:0003713; GO:0005042; GO:0005886; GO:0007411; GO:0009986; GO:0010976; GO:0016020; GO:0021965; GO:0030424; GO:0032584; GO:0033563; GO:0033564; GO:0042802; GO:0070374; GO:0098609; GO:0098685; GO:0098839; GO:0099170
GN006264	GN006264.1	P41367	81.1	175	182	421	1.81e-93	281	ACADM_PIG	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7)	Sus scrofa (Pig)	carnitine biosynthetic process [GO:0045329]; carnitine metabolic process, CoA-linked [GO:0019254]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; glycogen biosynthetic process [GO:0005978]; medium-chain fatty acid catabolic process [GO:0051793]; regulation of gluconeogenesis [GO:0006111]	acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; long-chain fatty acyl-CoA dehydrogenase activity [GO:0004466]; medium-chain fatty acyl-CoA dehydrogenase activity [GO:0070991]; short-chain fatty acyl-CoA dehydrogenase activity [GO:0016937]	axon [GO:0030424]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]	GO:0003995; GO:0004466; GO:0005759; GO:0005978; GO:0006111; GO:0006635; GO:0016937; GO:0019254; GO:0030424; GO:0031966; GO:0033539; GO:0042802; GO:0045329; GO:0050660; GO:0051793; GO:0070991
GN006265	GN006265.1	Q569D5	77.4	84	93	472	1.11e-41	144	SBP1_XENTR	Methanethiol oxidase (MTO) (EC 1.8.3.4) (Selenium-binding protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		methanethiol oxidase activity [GO:0018549]; selenium binding [GO:0008430]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0008430; GO:0016020; GO:0018549
GN006267	GN006267.1	Q8BH27	28.7	237	525	600	7.05e-19	93.6	MEGF9_MOUSE	Multiple epidermal growth factor-like domains protein 9 (Multiple EGF-like domains protein 9) (Epidermal growth factor-like protein 5) (EGF-like protein 5)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; basement membrane assembly [GO:0070831]; cell migration [GO:0016477]; substrate adhesion-dependent cell spreading [GO:0034446]; tissue development [GO:0009888]		basement membrane [GO:0005604]; laminin trimer [GO:0043256]; membrane [GO:0016020]	GO:0005604; GO:0007411; GO:0009887; GO:0009888; GO:0016020; GO:0016477; GO:0034446; GO:0043256; GO:0070831
GN006269	GN006269.1	F7J186	46.3	80	153	470	2.69e-15	75.1	NVD1_CIOIN	Cholesterol 7-desaturase nvd 1 (EC 1.14.19.21) (Neverland 1) (Nvd-Ci-1)	Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)	cholesterol metabolic process [GO:0008203]	2 iron, 2 sulfur cluster binding [GO:0051537]; cholesterol 7-desaturase [NAD(P)H] activity [GO:0170056]	membrane [GO:0016020]	GO:0008203; GO:0016020; GO:0051537; GO:0170056
GN006272	GN006272.1	F7J184	56.7	383	382	454	1.32e-166	476	NVD_XENLA	Cholesterol 7-desaturase nvd (EC 1.14.19.21) (Protein neverland) (Nvd protein) (nvd-Xl)	Xenopus laevis (African clawed frog)	cholesterol metabolic process [GO:0008203]	2 iron, 2 sulfur cluster binding [GO:0051537]; cholesterol 7-desaturase [NAD(P)H] activity [GO:0170056]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0005737; GO:0008203; GO:0016020; GO:0051537; GO:0170056
GN006274	GN006274.1	Q91YR5	48.9	522	498	698	4.69e-159	471	EFNMT_MOUSE	eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)]	Mus musculus (Mouse)		protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0016279
GN006275	GN006275.1	Q7ZYH1	49.7	453	598	520	1.80e-132	400	SIN1_XENLA	Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1)	Xenopus laevis (African clawed frog)	TORC2 signaling [GO:0038203]	enzyme-substrate adaptor activity [GO:0140767]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; TORC2 complex [GO:0031932]	GO:0000139; GO:0005546; GO:0005547; GO:0005634; GO:0005737; GO:0005741; GO:0005764; GO:0005765; GO:0005769; GO:0005770; GO:0005783; GO:0005789; GO:0005886; GO:0031901; GO:0031902; GO:0031932; GO:0038203; GO:0048471; GO:0140767
GN006276	GN006276.1	Q03167	24.7	692	600	851	1.75e-31	134	TGBR3_HUMAN	Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)	Homo sapiens (Human)	animal organ regeneration [GO:0031100]; BMP signaling pathway [GO:0030509]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell proliferation [GO:0060038]; cell migration [GO:0016477]; definitive erythrocyte differentiation [GO:0060318]; definitive hemopoiesis [GO:0060216]; epicardium-derived cardiac fibroblast cell development [GO:0060939]; epithelial to mesenchymal transition [GO:0001837]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; heart trabecula morphogenesis [GO:0061384]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; liver development [GO:0001889]; muscular septum morphogenesis [GO:0003150]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of extracellular matrix assembly [GO:1901202]; negative regulation of SMAD protein signal transduction [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; outflow tract morphogenesis [GO:0003151]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of gene expression [GO:0010628]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to follicle-stimulating hormone [GO:0032354]; response to hypoxia [GO:0001666]; response to luteinizing hormone [GO:0034699]; response to prostaglandin E [GO:0034695]; secondary palate development [GO:0062009]; transforming growth factor beta receptor complex assembly [GO:0007181]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]	activin binding [GO:0048185]; BMP binding [GO:0036122]; coreceptor activity [GO:0015026]; fibroblast growth factor binding [GO:0017134]; glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]; PDZ domain binding [GO:0030165]; SMAD binding [GO:0046332]; transforming growth factor beta binding [GO:0050431]; transforming growth factor beta receptor activity [GO:0005024]; transforming growth factor beta receptor activity, type III [GO:0070123]; transforming growth factor beta receptor binding [GO:0005160]; transmembrane signaling receptor activity [GO:0004888]; type II transforming growth factor beta receptor binding [GO:0005114]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; inhibin-betaglycan-ActRII complex [GO:0034673]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001666; GO:0001837; GO:0001889; GO:0003007; GO:0003150; GO:0003151; GO:0003223; GO:0004888; GO:0005024; GO:0005114; GO:0005160; GO:0005539; GO:0005576; GO:0005829; GO:0005886; GO:0006955; GO:0007179; GO:0007181; GO:0008201; GO:0009897; GO:0009986; GO:0010628; GO:0015026; GO:0016323; GO:0016477; GO:0017015; GO:0017134; GO:0030165; GO:0030336; GO:0030509; GO:0030511; GO:0030512; GO:0031100; GO:0032354; GO:0034673; GO:0034695; GO:0034699; GO:0035556; GO:0036122; GO:0043124; GO:0043235; GO:0046332; GO:0048185; GO:0050431; GO:0050680; GO:0055010; GO:0060038; GO:0060045; GO:0060216; GO:0060317; GO:0060318; GO:0060347; GO:0060391; GO:0060392; GO:0060412; GO:0060939; GO:0060979; GO:0061384; GO:0062009; GO:0070062; GO:0070123; GO:0090050; GO:1901202
GN006277	GN006277.1	Q708S3	24.0	446	426	558	2.77e-20	96.7	ASI4B_DANRE	Acid-sensing ion channel 4-B (ASIC4-B) (Acid-sensing ion channel 4.2) (Amiloride-sensitive cation channel 4-B) (ZASIC4.2)	Danio rerio (Zebrafish) (Brachydanio rerio)	response to steroid hormone [GO:0048545]; sodium ion transmembrane transport [GO:0035725]	monoatomic cation channel activity [GO:0005261]; sodium channel activity [GO:0005272]	plasma membrane [GO:0005886]	GO:0005261; GO:0005272; GO:0005886; GO:0035725; GO:0048545
GN006278	GN006278.1	P56962	37.7	302	313	302	1.66e-49	169	STX17_HUMAN	Syntaxin-17	Homo sapiens (Human)	autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; autophagosome-lysosome fusion [GO:0061909]; cellular response to starvation [GO:0009267]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; protein localization to phagophore assembly site [GO:0034497]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]	protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	autolysosome membrane [GO:0120281]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; lysosomal membrane [GO:0005765]; membrane fusion priming complex [GO:0120124]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; smooth endoplasmic reticulum membrane [GO:0030868]; SNARE complex [GO:0031201]	GO:0000149; GO:0000421; GO:0005484; GO:0005739; GO:0005765; GO:0005776; GO:0005789; GO:0005793; GO:0005829; GO:0006886; GO:0006887; GO:0006888; GO:0006906; GO:0007030; GO:0009267; GO:0012507; GO:0016236; GO:0016240; GO:0019901; GO:0019903; GO:0030134; GO:0030868; GO:0031201; GO:0031966; GO:0033116; GO:0034497; GO:0044233; GO:0048278; GO:0061909; GO:0097111; GO:0097352; GO:0120124; GO:0120281
GN006279	GN006279.1	Q9VAC5	37.7	624	666	732	1.51e-128	399	ADA17_DROME	ADAM 17-like protease (EC 3.4.24.-)	Drosophila melanogaster (Fruit fly)	commissural neuron axon guidance [GO:0071679]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of programmed cell death [GO:0043068]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	metalloendopeptidase activity [GO:0004222]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004222; GO:0005886; GO:0006509; GO:0007219; GO:0007220; GO:0016020; GO:0033209; GO:0040015; GO:0043068; GO:0071679; GO:1903427
GN006280	GN006280.1	F1REV3	28.3	769	760	740	5.52e-77	266	KRIT1_DANRE	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog) (Santa)	Danio rerio (Zebrafish) (Brachydanio rerio)	angiogenesis [GO:0001525]; anterior/posterior axis specification [GO:0009948]; atrioventricular valve morphogenesis [GO:0003181]; blood vessel development [GO:0001568]; blood vessel lumenization [GO:0072554]; blood vessel morphogenesis [GO:0048514]; cell redox homeostasis [GO:0045454]; endocardial cell development [GO:0060958]; endothelial cell morphogenesis [GO:0001886]; heart contraction [GO:0060047]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell differentiation [GO:0045602]; regulation of establishment of cell polarity [GO:2000114]; vacuole organization [GO:0007033]; vasculogenesis [GO:0001570]		anchoring junction [GO:0070161]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]	GO:0001525; GO:0001568; GO:0001570; GO:0001886; GO:0003007; GO:0003181; GO:0005856; GO:0005886; GO:0007033; GO:0007507; GO:0009948; GO:0016525; GO:0045454; GO:0045602; GO:0048514; GO:0060047; GO:0060958; GO:0070161; GO:0072554; GO:2000114
GN006281	GN006281.1	O75762	21.5	484	1132	1119	1.35e-10	69.7	TRPA1_HUMAN	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor)	Homo sapiens (Human)	calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to caffeine [GO:0071313]; cellular response to carbon dioxide [GO:0071244]; cellular response to cold [GO:0070417]; cellular response to food [GO:0071240]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to toxic substance [GO:0097237]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transport [GO:0006811]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of monoatomic anion transport [GO:1903793]; protein homotetramerization [GO:0051289]; regulation of blood circulation [GO:1903522]; regulation of neuronal action potential [GO:0098908]; response to cold [GO:0009409]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]; ureteric peristalsis [GO:0072105]; urinary bladder smooth muscle contraction [GO:0014832]; vasodilation [GO:0042311]	calcium channel activity [GO:0005262]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]; temperature-gated cation channel activity [GO:0097604]; voltage-gated calcium channel activity [GO:0005245]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]	GO:0005245; GO:0005262; GO:0005886; GO:0006811; GO:0006874; GO:0007166; GO:0009409; GO:0014832; GO:0015267; GO:0015278; GO:0016324; GO:0019233; GO:0030424; GO:0032421; GO:0034605; GO:0035774; GO:0042311; GO:0042802; GO:0050955; GO:0050968; GO:0050974; GO:0051289; GO:0070301; GO:0070417; GO:0070588; GO:0071240; GO:0071244; GO:0071313; GO:0072105; GO:0097237; GO:0097553; GO:0097604; GO:0098908; GO:1903522; GO:1903793; GO:1990760
GN006282	GN006282.1	Q9XF62	34.7	95	178	111	7.49e-10	57.0	SSNA1_CHLRE	Microtubule nucleation factor SSNA1 (CrSSNA1) (13 kDa deflagellation-inducible protein)	Chlamydomonas reinhardtii (Chlamydomonas smithii)	cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]		axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasmic microtubule [GO:0005881]	GO:0000226; GO:0005881; GO:0005930; GO:0036064; GO:0051301
GN006283	GN006283.1	Q8T5C6	79.0	423	465	436	2.07e-235	654	RXR_BIOGL	Retinoic acid receptor RXR (RXR-like protein) (Retinoid X receptor) (BgRXR)	Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail)		nuclear steroid receptor activity [GO:0003707]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0003707; GO:0005634; GO:0008270; GO:0043565
GN006287	GN006287.1	P0DX22	38.3	214	204	276	1.08e-43	150	FCNLN_PSEA6	L-fucono-1,5-lactonase (EC 3.1.1.120) (Fuconolactonase)	Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)		D-arabinonolactonase activity [GO:0047815]		GO:0047815
GN006289	GN006289.1	Q8NE28	26.8	388	654	680	9.69e-32	134	STKL1_HUMAN	Serine/threonine kinase-like domain-containing protein STKLD1 (Serine/threonine kinase-like domain-containing protein 1) (Sugen kinase 071)	Homo sapiens (Human)		ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]		GO:0004674; GO:0005524
GN006290	GN006290.1	Q6GQ95	64.7	139	140	201	1.26e-53	170	MED22_XENLA	Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5)	Xenopus laevis (African clawed frog)	regulation of transcription by RNA polymerase II [GO:0006357]	transcription coregulator activity [GO:0003712]	mediator complex [GO:0016592]	GO:0003712; GO:0006357; GO:0016592
GN006291	GN006291.1	O57592	76.2	269	268	266	2.30e-133	380	RL7A_TAKRU	Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) (Surfeit locus protein 3)	Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)	ribosome biogenesis [GO:0042254]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005737; GO:0042254; GO:1990904
GN006292	GN006292.1	Q8TBB0	41.0	61	74	222	3.01e-11	59.3	THAP6_HUMAN	THAP domain-containing protein 6	Homo sapiens (Human)			microtubule cytoskeleton [GO:0015630]	GO:0015630
GN006294	GN006294.1	Q5M886	37.6	330	328	337	1.90e-77	243	ADPRM_RAT	Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.16) (EC 3.6.1.53) (ADPRibase-Mn) (CDP-choline phosphohydrolase)	Rattus norvegicus (Rat)		2',3'-cyclic-nucleotide 2'-phosphodiesterase activity [GO:0008663]; ADP phosphatase activity [GO:0043262]; ADP-ribose diphosphatase activity [GO:0047631]; CDP-glycerol diphosphatase activity [GO:0047734]; manganese ion binding [GO:0030145]		GO:0008663; GO:0030145; GO:0043262; GO:0047631; GO:0047734
GN006295	GN006295.1	P18910	38.2	1000	984	1057	9.52e-199	602	ANPRA_RAT	Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)	Rattus norvegicus (Rat)	cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	ANPR-A receptor complex [GO:1990620]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005789; GO:0005886; GO:0006182; GO:0007166; GO:0007168; GO:0008217; GO:0016020; GO:0016941; GO:0017046; GO:0031965; GO:0035556; GO:0042417; GO:0042562; GO:0043114; GO:0043235; GO:0048662; GO:1990620
GN006302	GN006302.1	Q20930	35.8	81	162	509	3.22e-10	60.8	MIG17_CAEEL	Metalloprotease mig-17 (EC 3.4.24.-) (Abnormal cell migration protein 17)	Caenorhabditis elegans	gonad morphogenesis [GO:0035262]; intracellular protein localization [GO:0008104]; protein autoprocessing [GO:0016540]; regulation of cell migration [GO:0030334]; regulation of distal tip cell migration [GO:1903354]; zymogen activation [GO:0031638]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	basement membrane [GO:0005604]; extracellular region [GO:0005576]	GO:0004222; GO:0005576; GO:0005604; GO:0008104; GO:0008237; GO:0016540; GO:0030334; GO:0031638; GO:0035262; GO:1903354
GN006304	GN006304.1	Q20930	29.8	252	560	509	2.68e-20	97.8	MIG17_CAEEL	Metalloprotease mig-17 (EC 3.4.24.-) (Abnormal cell migration protein 17)	Caenorhabditis elegans	gonad morphogenesis [GO:0035262]; intracellular protein localization [GO:0008104]; protein autoprocessing [GO:0016540]; regulation of cell migration [GO:0030334]; regulation of distal tip cell migration [GO:1903354]; zymogen activation [GO:0031638]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	basement membrane [GO:0005604]; extracellular region [GO:0005576]	GO:0004222; GO:0005576; GO:0005604; GO:0008104; GO:0008237; GO:0016540; GO:0030334; GO:0031638; GO:0035262; GO:1903354
GN006307	GN006307.1	Q9WUQ1	35.4	130	947	967	4.53e-09	64.3	ATS1_RAT	A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-)	Rattus norvegicus (Rat)	cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to vitamin D [GO:0071305]; extracellular matrix organization [GO:0030198]; heart trabecula formation [GO:0060347]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; ovulation from ovarian follicle [GO:0001542]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of neuron projection development [GO:0010976]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; proteolysis [GO:0006508]	heparin binding [GO:0008201]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	basement membrane [GO:0005604]; cytoplasmic vesicle [GO:0031410]; extracellular matrix [GO:0031012]	GO:0001542; GO:0001822; GO:0004222; GO:0005604; GO:0006508; GO:0008201; GO:0008270; GO:0010976; GO:0016525; GO:0030198; GO:0031012; GO:0031410; GO:0060347; GO:0071305; GO:0071374; GO:0071380; GO:1900087; GO:1904707; GO:1904754
GN006309	GN006309.1	Q91VB4	31.4	207	216	1002	1.46e-24	104	HPS3_MOUSE	BLOC-2 complex member HPS3 (Cocoa protein) (Hermansky-Pudlak syndrome 3 protein homolog)	Mus musculus (Mouse)	eye pigmentation [GO:0048069]; melanosome assembly [GO:1903232]; pigmentation [GO:0043473]; platelet dense granule organization [GO:0060155]		BLOC-2 complex [GO:0031084]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]	GO:0005737; GO:0005769; GO:0005829; GO:0031084; GO:0043473; GO:0048069; GO:0060155; GO:1903232
GN006312	GN006312.1	Q32LP4	49.2	1152	1205	1117	0.0	973	S4A10_BOVIN	Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10)	Bos taurus (Bovine)	bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; visual perception [GO:0007601]	monoatomic anion transmembrane transporter activity [GO:0008509]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]	apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; presynapse [GO:0098793]; somatodendritic compartment [GO:0036477]; synapse [GO:0045202]	GO:0005452; GO:0007601; GO:0008509; GO:0008510; GO:0015701; GO:0016323; GO:0016324; GO:0030425; GO:0036477; GO:0043025; GO:0043204; GO:0043679; GO:0045202; GO:0048172; GO:0051453; GO:0098793; GO:0098794; GO:0098982
GN006313	GN006313.1	Q07263	38.0	158	177	495	1.01e-31	122	ACHA3_BOVIN	Neuronal acetylcholine receptor subunit alpha-3	Bos taurus (Bovine)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005783; GO:0005794; GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0035095; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060; GO:0098793; GO:0099171
GN006317	GN006317.1	P13944	36.2	188	556	3124	4.30e-24	111	COCA1_CHICK	Collagen alpha-1(XII) chain (Fibrochimerin)	Gallus gallus (Chicken)	endodermal cell differentiation [GO:0035987]		interstitial matrix [GO:0005614]	GO:0005614; GO:0035987
GN006318	GN006318.1	Q5UR46	35.0	200	618	297	1.96e-18	89.7	YR571_MIMIV	Uncharacterized protein R571 (EC 3.1.1.-)	Acanthamoeba polyphaga mimivirus (APMV)	lipid catabolic process [GO:0016042]	hydrolase activity [GO:0016787]	membrane [GO:0016020]	GO:0016020; GO:0016042; GO:0016787
GN006321	GN006321.1	Q5UR46	35.0	200	527	297	3.26e-19	91.7	YR571_MIMIV	Uncharacterized protein R571 (EC 3.1.1.-)	Acanthamoeba polyphaga mimivirus (APMV)	lipid catabolic process [GO:0016042]	hydrolase activity [GO:0016787]	membrane [GO:0016020]	GO:0016020; GO:0016042; GO:0016787
GN006322	GN006322.1	Q86VW0	32.6	697	908	696	8.75e-105	343	SESD1_HUMAN	SEC14 domain and spectrin repeat-containing protein 1 (Huntingtin-interacting protein-like protein) (Protein Solo)	Homo sapiens (Human)	negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]	phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]	intermediate filament cytoskeleton [GO:0045111]	GO:0005546; GO:0010314; GO:0032266; GO:0043325; GO:0045111; GO:0070273; GO:0070300; GO:0080025; GO:1904878
GN006323	GN006323.1	Q6PDN3	41.9	93	421	1941	2.06e-14	79.3	MYLK_MOUSE	Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]	Mus musculus (Mouse)	aorta smooth muscle tissue morphogenesis [GO:0060414]; bleb assembly [GO:0032060]; cellular hypotonic response [GO:0071476]; cellular response to calcium ion [GO:0071277]; cellular response to potassium ion [GO:0035865]; cellular response to xenobiotic stimulus [GO:0071466]; neurotransmitter receptor transport to postsynaptic membrane [GO:0098969]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of vascular associated smooth muscle contraction [GO:1904695]; positive regulation of wound healing [GO:0090303]; regulation of synaptic vesicle endocytosis [GO:1900242]; smooth muscle contraction [GO:0006939]; tonic smooth muscle contraction [GO:0014820]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; myosin light chain kinase activity [GO:0004687]; scaffold protein binding [GO:0097110]	actin cytoskeleton [GO:0015629]; cell-cell junction [GO:0005911]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; synapse [GO:0045202]	GO:0001725; GO:0004687; GO:0005524; GO:0005737; GO:0005886; GO:0005911; GO:0006939; GO:0014820; GO:0015629; GO:0019899; GO:0030027; GO:0030335; GO:0032060; GO:0032154; GO:0035865; GO:0045202; GO:0051928; GO:0060414; GO:0071277; GO:0071466; GO:0071476; GO:0090303; GO:0097110; GO:0098969; GO:1900242; GO:1904695
GN006324	GN006324.1	A2AJ77	47.0	166	226	365	3.39e-43	152	PRD12_MOUSE	PR domain zinc finger protein 12 (PR domain-containing protein 12)	Mus musculus (Mouse)	detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; neuron fate specification [GO:0048665]; neuron projection development [GO:0031175]; protein methylation [GO:0006479]; regulation of gene expression [GO:0010468]; sensory perception of pain [GO:0019233]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone chaperone activity [GO:0140713]; histone methyltransferase binding [GO:1990226]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000981; GO:0001227; GO:0001228; GO:0005634; GO:0005654; GO:0006479; GO:0010468; GO:0019233; GO:0022008; GO:0031175; GO:0048665; GO:0050965; GO:0140713; GO:1990226
GN006326	GN006326.1	Q27218	31.3	265	325	507	5.43e-36	139	ACH7_CAEEL	Acetylcholine receptor subunit beta-type lev-1 (Levamisole-resistant protein 1)	Caenorhabditis elegans	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of egg-laying behavior [GO:0046662]; regulation of locomotion [GO:0040012]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]; transmembrane transport [GO:0055085]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0040012; GO:0042391; GO:0043005; GO:0043025; GO:0045202; GO:0045211; GO:0046662; GO:0055085
GN006327	GN006327.1	P43143	32.6	313	389	493	4.54e-39	149	ACHA6_RAT	Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Rat)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0014059; GO:0022848; GO:0030594; GO:0032991; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN006329	GN006329.1	P18845	30.6	317	398	512	1.04e-39	151	ACHA3_CARAU	Neuronal acetylcholine receptor subunit alpha-3 (GF-alpha-3)	Carassius auratus (Goldfish)	behavioral response to nicotine [GO:0035095]; nervous system development [GO:0007399]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synaptic membrane [GO:0097060]	GO:0005783; GO:0005794; GO:0005886; GO:0005892; GO:0007165; GO:0007399; GO:0015464; GO:0022848; GO:0035095; GO:0045211; GO:0060084; GO:0097060
GN006330	GN006330.1	P43143	32.6	313	389	493	3.28e-39	149	ACHA6_RAT	Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Rat)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0014059; GO:0022848; GO:0030594; GO:0032991; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN006331	GN006331.1	P18845	30.0	317	398	512	2.51e-37	144	ACHA3_CARAU	Neuronal acetylcholine receptor subunit alpha-3 (GF-alpha-3)	Carassius auratus (Goldfish)	behavioral response to nicotine [GO:0035095]; nervous system development [GO:0007399]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synaptic membrane [GO:0097060]	GO:0005783; GO:0005794; GO:0005886; GO:0005892; GO:0007165; GO:0007399; GO:0015464; GO:0022848; GO:0035095; GO:0045211; GO:0060084; GO:0097060
GN006337	GN006337.1	Q80W00	31.2	878	895	888	3.56e-64	236	PP1RA_MOUSE	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (Phosphatase 1 nuclear targeting subunit)	Mus musculus (Mouse)	negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of mitotic DNA damage checkpoint [GO:1904290]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000806]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein stabilization [GO:0050821]; RNA polymerase II promoter clearance [GO:0001111]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]	enzyme-substrate adaptor activity [GO:0140767]; metal ion binding [GO:0046872]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357]	GO:0000781; GO:0000785; GO:0001111; GO:0004864; GO:0005634; GO:0005654; GO:0005694; GO:0006366; GO:0006368; GO:0008157; GO:0010667; GO:0016604; GO:0019888; GO:0032206; GO:0032968; GO:0034244; GO:0046872; GO:0050821; GO:0072357; GO:0140767; GO:1904290; GO:2000806
GN006340	GN006340.1	Q92574	36.3	336	927	1164	1.06e-24	115	TSC1_HUMAN	Hamartin (Tuberous sclerosis 1 protein)	Homo sapiens (Human)	activation of GTPase activity [GO:0090630]; adult locomotory behavior [GO:0008344]; cell-matrix adhesion [GO:0007160]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to starvation [GO:0009267]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of focal adhesion assembly [GO:0051894]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of cell-matrix adhesion [GO:0001952]; regulation of stress fiber assembly [GO:0051492]; response to insulin [GO:0032868]	ATPase inhibitor activity [GO:0042030]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein folding chaperone [GO:0044183]; protein-folding chaperone binding [GO:0051087]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; TSC1-TSC2 complex [GO:0033596]	GO:0001952; GO:0005634; GO:0005737; GO:0005765; GO:0005829; GO:0005886; GO:0005938; GO:0007160; GO:0008285; GO:0008344; GO:0009267; GO:0016020; GO:0016242; GO:0030027; GO:0030544; GO:0032007; GO:0032780; GO:0032868; GO:0032991; GO:0033596; GO:0036294; GO:0042030; GO:0044183; GO:0048471; GO:0050821; GO:0051087; GO:0051492; GO:0051726; GO:0051879; GO:0051894; GO:0090630; GO:0101031; GO:1904262
GN006341	GN006341.1	Q9H0K4	46.5	512	576	717	7.02e-125	386	RSH6A_HUMAN	Radial spoke head protein 6 homolog A (Radial spoke head-like protein 1)	Homo sapiens (Human)	axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]; manchette disassembly [GO:1905199]; sperm flagellum assembly [GO:0120316]		9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; radial spoke [GO:0001534]; radial spoke head [GO:0001535]; sperm flagellum [GO:0036126]	GO:0001534; GO:0001535; GO:0003341; GO:0005930; GO:0030317; GO:0035082; GO:0036126; GO:0097729; GO:0120316; GO:1905199
GN006344	GN006344.1	Q9Z2F6	28.1	221	2465	448	1.86e-12	75.9	BCL3_MOUSE	B-cell lymphoma 3 protein homolog (BCL-3)	Mus musculus (Mouse)	antimicrobial humoral response [GO:0019730]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of type II interferon production [GO:0032729]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to UV-C [GO:0010225]; response to virus [GO:0009615]; spleen development [GO:0048536]; T-helper 1 type immune response [GO:0042088]; T-helper 2 cell differentiation [GO:0045064]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	Bcl3-Bcl10 complex [GO:0032996]; Bcl3/NF-kappaB2 complex [GO:0033257]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	GO:0002268; GO:0002315; GO:0002455; GO:0002467; GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006606; GO:0006974; GO:0007249; GO:0009615; GO:0010225; GO:0019730; GO:0030198; GO:0030330; GO:0030496; GO:0030674; GO:0032717; GO:0032720; GO:0032729; GO:0032733; GO:0032991; GO:0032996; GO:0033257; GO:0036064; GO:0042088; GO:0042742; GO:0042771; GO:0042826; GO:0042832; GO:0042981; GO:0043066; GO:0045064; GO:0045727; GO:0045892; GO:0045893; GO:0045944; GO:0046426; GO:0048471; GO:0048536; GO:0140297; GO:1901222; GO:1901223
GN006348	GN006348.1	P15989	22.9	593	1429	3137	2.76e-30	135	CO6A3_CHICK	Collagen alpha-3(VI) chain	Gallus gallus (Chicken)		serine-type endopeptidase inhibitor activity [GO:0004867]	collagen type VI trimer [GO:0005589]	GO:0004867; GO:0005589
GN006352	GN006352.1	Q09324	38.7	377	456	428	2.08e-77	250	GCNT1_MOUSE	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GlcNAcT) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT) (Leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GnT-L)	Mus musculus (Mouse)	cell adhesion molecule production [GO:0060352]; glycoprotein biosynthetic process [GO:0009101]; kidney morphogenesis [GO:0060993]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte tethering or rolling [GO:1903238]; protein O-linked glycosylation via N-acetyl-galactosamine [GO:0016266]; tissue morphogenesis [GO:0048729]	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]	extracellular region [GO:0005576]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; nuclear speck [GO:0016607]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0003829; GO:0005576; GO:0005802; GO:0009101; GO:0016266; GO:0016607; GO:0031985; GO:0048729; GO:0050901; GO:0060352; GO:0060993; GO:1903238
GN006355	GN006355.1	Q90WR8	29.0	724	801	771	1.04e-27	123	SP3_CHICK	Transcription factor Sp3	Gallus gallus (Chicken)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	nucleus [GO:0005634]; PML body [GO:0016605]; transcription repressor complex [GO:0017053]	GO:0000978; GO:0000981; GO:0001227; GO:0003682; GO:0005634; GO:0006357; GO:0016605; GO:0017053; GO:0045944; GO:0061629
GN006356	GN006356.1	P35224	71.0	829	820	818	0.0	1051	CTNB_URECA	Catenin beta (Beta-catenin)	Urechis caupo (Innkeeper worm) (Spoonworm)	cell adhesion [GO:0007155]	cadherin binding [GO:0045296]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; membrane [GO:0016020]	GO:0005737; GO:0005856; GO:0005911; GO:0007155; GO:0016020; GO:0045296
GN006358	GN006358.1	Q3T0B6	30.2	169	258	278	3.11e-14	73.9	C1QBP_BOVIN	Complement component 1 Q subcomponent-binding protein, mitochondrial	Bos taurus (Bovine)	cytosolic ribosome assembly [GO:0042256]; mitochondrial RNA catabolic process [GO:0000957]; negative regulation of defense response to virus [GO:0050687]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of complement activation [GO:0030449]	adrenergic receptor binding [GO:0031690]; C5-methylcytidine-containing RNA reader activity [GO:0062153]; complement component C1q complex binding [GO:0001849]; enzyme inhibitor activity [GO:0004857]; hyaluronic acid binding [GO:0005540]; kininogen binding [GO:0030984]; mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; transcription corepressor activity [GO:0003714]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrial matrix [GO:0005759]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GO:0000122; GO:0000957; GO:0001849; GO:0003714; GO:0003729; GO:0004857; GO:0005540; GO:0005576; GO:0005634; GO:0005730; GO:0005737; GO:0005759; GO:0005829; GO:0005886; GO:0009986; GO:0030449; GO:0030984; GO:0031690; GO:0032689; GO:0032695; GO:0032991; GO:0039534; GO:0039536; GO:0042256; GO:0043065; GO:0043491; GO:0045785; GO:0048025; GO:0050687; GO:0051897; GO:0062153; GO:0070131; GO:0090023; GO:0097177; GO:1900026; GO:1901165; GO:2000042; GO:2000510
GN006359	GN006359.1	Q9CQR6	84.9	192	199	305	1.43e-127	364	PPP6_MOUSE	Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16)	Mus musculus (Mouse)	cGAS/STING signaling pathway [GO:0140896]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; protein dephosphorylation [GO:0006470]	protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0000082; GO:0004722; GO:0005737; GO:0005739; GO:0005829; GO:0006470; GO:0140896; GO:0160049
GN006360	GN006360.1	Q6CSW8	30.1	153	249	184	1.04e-10	62.4	UBC12_KLULA	NEDD8-conjugating enzyme UBC12 (EC 2.3.2.34) (RUB1-conjugating enzyme) (Ubiquitin carrier protein 12)	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)	protein neddylation [GO:0045116]	NEDD8 conjugating enzyme activity [GO:0061654]		GO:0045116; GO:0061654
GN006371	GN006371.1	Q924H0	21.8	377	382	417	1.49e-13	75.1	NPFF2_MOUSE	Neuropeptide FF receptor 2 (G protein-coupled receptor 74) (Neuropeptide NPFF receptor)	Mus musculus (Mouse)	cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; regulation of MAPK cascade [GO:0043408]	G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]	actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007186; GO:0007218; GO:0008188; GO:0015629; GO:0031628; GO:0032870; GO:0043408
GN006374	GN006374.1	P36964	28.0	257	271	278	2.85e-20	90.9	DMB_SQUAC	Proteolipid protein DM beta	Squalus acanthias (Spiny dogfish)	neuron projection development [GO:0031175]		axonal growth cone [GO:0044295]; filopodium [GO:0030175]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	GO:0005886; GO:0030175; GO:0031175; GO:0043025; GO:0044295
GN006376	GN006376.1	P52430	38.5	275	357	355	2.31e-52	180	PON1_MOUSE	Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (Serum aryldialkylphosphatase 1)	Mus musculus (Mouse)	blood circulation [GO:0008015]; carboxylic acid catabolic process [GO:0046395]; cholesterol metabolic process [GO:0008203]; lactone catabolic process [GO:1901335]; organophosphate catabolic process [GO:0046434]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of cholesterol efflux [GO:0010875]; response to fluoride [GO:1902617]; response to toxic substance [GO:0009636]	acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; aryldialkylphosphatase activity [GO:0004063]; arylesterase activity [GO:0004064]; calcium ion binding [GO:0005509]; high-density lipoprotein particle binding [GO:0008035]; phospholipid binding [GO:0005543]; protein homodimerization activity [GO:0042803]	extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; spherical high-density lipoprotein particle [GO:0034366]	GO:0004063; GO:0004064; GO:0005509; GO:0005543; GO:0005576; GO:0008015; GO:0008035; GO:0008203; GO:0009636; GO:0010875; GO:0034364; GO:0034366; GO:0042803; GO:0046395; GO:0046434; GO:0046470; GO:0102007; GO:1901335; GO:1902617
GN006378	GN006378.1	P27169	37.1	318	326	355	2.22e-54	184	PON1_HUMAN	Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1)	Homo sapiens (Human)	carboxylic acid catabolic process [GO:0046395]; lactone catabolic process [GO:1901335]; organophosphate catabolic process [GO:0046434]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of cholesterol efflux [GO:0010875]; response to toxic substance [GO:0009636]	acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; aryldialkylphosphatase activity [GO:0004063]; arylesterase activity [GO:0004064]; calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543]; protein homodimerization activity [GO:0042803]	blood microparticle [GO:0072562]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; spherical high-density lipoprotein particle [GO:0034366]	GO:0004063; GO:0004064; GO:0005509; GO:0005543; GO:0005576; GO:0005789; GO:0009636; GO:0010875; GO:0034364; GO:0034366; GO:0042803; GO:0046395; GO:0046434; GO:0046470; GO:0070062; GO:0072562; GO:0102007; GO:1901335
GN006381	GN006381.1	P52430	34.5	267	339	355	2.06e-41	150	PON1_MOUSE	Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (Serum aryldialkylphosphatase 1)	Mus musculus (Mouse)	blood circulation [GO:0008015]; carboxylic acid catabolic process [GO:0046395]; cholesterol metabolic process [GO:0008203]; lactone catabolic process [GO:1901335]; organophosphate catabolic process [GO:0046434]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of cholesterol efflux [GO:0010875]; response to fluoride [GO:1902617]; response to toxic substance [GO:0009636]	acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; aryldialkylphosphatase activity [GO:0004063]; arylesterase activity [GO:0004064]; calcium ion binding [GO:0005509]; high-density lipoprotein particle binding [GO:0008035]; phospholipid binding [GO:0005543]; protein homodimerization activity [GO:0042803]	extracellular region [GO:0005576]; high-density lipoprotein particle [GO:0034364]; spherical high-density lipoprotein particle [GO:0034366]	GO:0004063; GO:0004064; GO:0005509; GO:0005543; GO:0005576; GO:0008015; GO:0008035; GO:0008203; GO:0009636; GO:0010875; GO:0034364; GO:0034366; GO:0042803; GO:0046395; GO:0046434; GO:0046470; GO:0102007; GO:1901335; GO:1902617
GN006382	GN006382.1	Q5EAE6	41.1	107	107	102	2.11e-15	68.9	DAP1_BOVIN	Death-associated protein 1 (DAP-1)	Bos taurus (Bovine)	apoptotic signaling pathway [GO:0097190]; negative regulation of autophagy [GO:0010507]; ribosome hibernation [GO:0141014]	ribosome binding [GO:0043022]		GO:0010507; GO:0043022; GO:0097190; GO:0141014
GN006383	GN006383.1	P13395	67.3	2461	2462	2415	0.0	3139	SPTCA_DROME	Spectrin alpha chain	Drosophila melanogaster (Fruit fly)	actin cytoskeleton organization [GO:0030036]; axon midline choice point recognition [GO:0016199]; central nervous system development [GO:0007417]; cytoskeleton organization [GO:0007010]; fusome organization [GO:0045478]; germarium-derived female germ-line cyst formation [GO:0030727]; germarium-derived oocyte fate determination [GO:0007294]; long-term strengthening of neuromuscular junction [GO:0042062]; maintenance of presynaptic active zone structure [GO:0048790]; negative regulation of microtubule depolymerization [GO:0007026]; neuromuscular synaptic transmission [GO:0007274]; oocyte construction [GO:0007308]; ovarian fusome organization [GO:0030723]; plasma membrane organization [GO:0007009]; positive regulation of hippo signaling [GO:0035332]; regulation of synapse organization [GO:0050807]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cortical actin cytoskeleton [GO:0030864]; fusome [GO:0045169]; Golgi apparatus [GO:0005794]; lateral plasma membrane [GO:0016328]; motile cilium [GO:0031514]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; spectrosome [GO:0045170]	GO:0003779; GO:0005509; GO:0005794; GO:0005886; GO:0005938; GO:0007009; GO:0007010; GO:0007026; GO:0007274; GO:0007294; GO:0007308; GO:0007417; GO:0008017; GO:0016199; GO:0016323; GO:0016324; GO:0016328; GO:0030036; GO:0030054; GO:0030723; GO:0030727; GO:0030864; GO:0031514; GO:0031594; GO:0035332; GO:0042062; GO:0045169; GO:0045170; GO:0045478; GO:0048790; GO:0050807; GO:0051015
GN006384	GN006384.1	Q16549	53.8	617	823	785	4.65e-224	652	PCSK7_HUMAN	Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7)	Homo sapiens (Human)	peptide hormone processing [GO:0016486]; protein processing [GO:0016485]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0004252; GO:0005802; GO:0008233; GO:0016485; GO:0016486
GN006385	GN006385.1	Q9BTY2	51.1	438	460	467	4.00e-172	494	FUCO2_HUMAN	Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2)	Homo sapiens (Human)	fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]; regulation of entry of bacterium into host cell [GO:2000535]; response to bacterium [GO:0009617]	alpha-L-fucosidase activity [GO:0004560]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0004560; GO:0005576; GO:0005764; GO:0005788; GO:0006004; GO:0009617; GO:0016139; GO:0035578; GO:0070062; GO:2000535
GN006386	GN006386.1	A5YVV0	27.5	630	731	661	1.63e-62	224	LAC3_ANOGA	Multicopper oxidase 3 (AgMCO3) (EC 1.10.3.2) (Laccase-3)	Anopheles gambiae (African malaria mosquito)		copper ion binding [GO:0005507]; hydroquinone:oxygen oxidoreductase activity [GO:0052716]	extracellular region [GO:0005576]	GO:0005507; GO:0005576; GO:0052716
GN006388	GN006388.1	A5YVV0	27.7	636	658	661	7.45e-60	215	LAC3_ANOGA	Multicopper oxidase 3 (AgMCO3) (EC 1.10.3.2) (Laccase-3)	Anopheles gambiae (African malaria mosquito)		copper ion binding [GO:0005507]; hydroquinone:oxygen oxidoreductase activity [GO:0052716]	extracellular region [GO:0005576]	GO:0005507; GO:0005576; GO:0052716
GN006392	GN006392.1	A5ABG0	23.4	2321	2587	3902	4.63e-123	441	PYNA_ASPNC	Hybrid PKS-NRPS synthetase pynA (EC 2.3.1.-) (EC 6.3.2.-) (Pyranonigrin biosynthesis cluster protein A)	Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)	fatty acid biosynthetic process [GO:0006633]; lactone biosynthetic process [GO:1901336]; secondary metabolic process [GO:0019748]; secondary metabolite biosynthetic process [GO:0044550]	fatty acid synthase activity [GO:0004312]; oxidoreductase activity [GO:0016491]; phosphopantetheine binding [GO:0031177]		GO:0004312; GO:0006633; GO:0016491; GO:0019748; GO:0031177; GO:0044550; GO:1901336
GN006393	GN006393.1	Q3UWM4	51.0	49	196	940	1.36e-10	63.2	KDM7A_MOUSE	Lysine-specific demethylase 7A (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) (EC 1.14.11.65)	Mus musculus (Mouse)	chromatin remodeling [GO:0006338]; midbrain development [GO:0030901]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone demethylase activity [GO:0032452]; histone H3K27me2/H3K27me3 demethylase activity [GO:0071558]; histone H3K36 demethylase activity [GO:0051864]; histone H3K9 demethylase activity [GO:0032454]; histone H3K9me/H3K9me2 demethylase activity [GO:0140683]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0003712; GO:0005506; GO:0005654; GO:0005730; GO:0006338; GO:0006357; GO:0008270; GO:0016706; GO:0030901; GO:0032452; GO:0032454; GO:0035575; GO:0045893; GO:0051864; GO:0071558; GO:0140683
GN006396	GN006396.1	Q6PDH0	48.6	346	1620	1371	4.13e-63	241	PHLB1_MOUSE	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha)	Mus musculus (Mouse)	basement membrane organization [GO:0071711]		basal cortex [GO:0045180]	GO:0045180; GO:0071711
GN006397	GN006397.1	Q5M9H0	41.7	733	830	663	4.49e-64	230	ANKS3_RAT	Ankyrin repeat and SAM domain-containing protein 3	Rattus norvegicus (Rat)			cilium [GO:0005929]; cytoplasm [GO:0005737]	GO:0005737; GO:0005929
GN006398	GN006398.1	Q7RTX9	27.8	558	609	510	4.11e-57	203	MOT14_HUMAN	Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14)	Homo sapiens (Human)	carboxylic acid transmembrane transport [GO:1905039]	monocarboxylic acid transmembrane transporter activity [GO:0008028]	plasma membrane [GO:0005886]	GO:0005886; GO:0008028; GO:1905039
GN006400	GN006400.1	Q8NDA2	23.0	522	660	5079	2.43e-13	77.8	HMCN2_HUMAN	Hemicentin-2	Homo sapiens (Human)	homophilic cell-cell adhesion [GO:0007156]; synapse organization [GO:0050808]	axon guidance receptor activity [GO:0008046]; calcium ion binding [GO:0005509]	axon [GO:0030424]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; extracellular matrix [GO:0031012]; neuronal cell body [GO:0043025]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005938; GO:0007156; GO:0008046; GO:0030054; GO:0030424; GO:0031012; GO:0032154; GO:0043025; GO:0050808; GO:0140144
GN006406	GN006406.1	A2ASS6	27.5	269	346	35213	1.30e-20	97.1	TITIN_MOUSE	Titin (EC 2.7.11.1) (Connectin)	Mus musculus (Mouse)	adult heart development [GO:0007512]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue development [GO:0048738]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; ventricular system development [GO:0021591]	actin filament binding [GO:0051015]; actinin binding [GO:0042805]; ankyrin binding [GO:0030506]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; muscle alpha-actinin binding [GO:0051371]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; structural molecule activity conferring elasticity [GO:0097493]; telethonin binding [GO:0031433]	A band [GO:0031672]; condensed nuclear chromosome [GO:0000794]; I band [GO:0031674]; M band [GO:0031430]; muscle myosin complex [GO:0005859]; myofibril [GO:0030016]; nucleus [GO:0005634]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]; titin-telethonin complex [GO:1990733]; Z disc [GO:0030018]	GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005634; GO:0005859; GO:0005865; GO:0006936; GO:0007507; GO:0007512; GO:0008307; GO:0010628; GO:0019887; GO:0019899; GO:0019901; GO:0021591; GO:0030016; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042803; GO:0042805; GO:0043056; GO:0045214; GO:0048738; GO:0048769; GO:0050714; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0055013; GO:0060048; GO:0060419; GO:0097493; GO:0106310; GO:1901897; GO:1990733
GN006407	GN006407.1	Q03601	31.7	126	472	974	8.65e-11	68.2	NHL1_CAEEL	RING finger protein nhl-1	Caenorhabditis elegans	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]		GO:0000209; GO:0004842; GO:0016567; GO:0043161; GO:0046872; GO:0061630
GN006408	GN006408.1	Q03601	32.3	133	474	974	5.35e-12	72.0	NHL1_CAEEL	RING finger protein nhl-1	Caenorhabditis elegans	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]		GO:0000209; GO:0004842; GO:0016567; GO:0043161; GO:0046872; GO:0061630
GN006409	GN006409.1	Q03601	32.8	125	297	974	7.28e-13	72.4	NHL1_CAEEL	RING finger protein nhl-1	Caenorhabditis elegans	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]		GO:0000209; GO:0004842; GO:0016567; GO:0043161; GO:0046872; GO:0061630
GN006410	GN006410.1	Q9R1R2	47.6	63	484	744	1.62e-12	73.6	TRIM3_MOUSE	Tripartite motif-containing protein 3 (EC 2.3.2.27) (RING finger protein 22) (RING finger protein HAC1)	Mus musculus (Mouse)	neural precursor cell proliferation [GO:0061351]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]; toll-like receptor signaling pathway [GO:0002224]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; postsynapse [GO:0098794]	GO:0000209; GO:0002224; GO:0004842; GO:0005737; GO:0005769; GO:0005794; GO:0008270; GO:0016567; GO:0030425; GO:0034141; GO:0042802; GO:0043161; GO:0061351; GO:0061630; GO:0070534; GO:0098794; GO:0098978; GO:0140252
GN006412	GN006412.1	Q8K3K7	41.2	187	274	278	3.20e-37	135	PLCB_MOUSE	1-acyl-sn-glycerol-3-phosphate acyltransferase beta (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 2) (1-AGP acyltransferase 2) (1-AGPAT 2) (Lysophosphatidic acid acyltransferase beta) (LPAAT-beta)	Mus musculus (Mouse)	CDP-diacylglycerol biosynthetic process [GO:0016024]; epidermis development [GO:0008544]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]; positive regulation of cytokine production [GO:0001819]; response to xenobiotic stimulus [GO:0009410]; triglyceride biosynthetic process [GO:0019432]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0001819; GO:0003841; GO:0005783; GO:0005789; GO:0006654; GO:0008544; GO:0008654; GO:0009410; GO:0016024; GO:0019432
GN006413	GN006413.1	Q99PR0	49.1	727	759	747	3.21e-243	697	POMT1_RAT	Protein O-mannosyl-transferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1)	Rattus norvegicus (Rat)	extracellular matrix organization [GO:0030198]; positive regulation of protein O-linked glycosylation [GO:1904100]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via mannose [GO:0035269]	dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]	acrosomal vesicle [GO:0001669]; dolichyl-phosphate-mannose-protein mannosyltransferase complex [GO:0031502]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; sarcoplasmic reticulum [GO:0016529]	GO:0000030; GO:0001669; GO:0004169; GO:0005783; GO:0005789; GO:0006493; GO:0016529; GO:0030198; GO:0031502; GO:0035269; GO:1904100
GN006414	GN006414.1	Q95T19	29.1	261	419	464	5.06e-24	107	SLIMP_DROME	Serine--tRNA synthetase-like protein Slimp (Seryl-tRNA synthetase-like insect mitochondrial protein)	Drosophila melanogaster (Fruit fly)	mitochondrial seryl-tRNA aminoacylation [GO:0070158]	nucleotide binding [GO:0000166]; serine-tRNA ligase activity [GO:0004828]; tRNA binding [GO:0000049]; tRNA ligase activator activity [GO:0140733]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; serine-tRNA ligase complex [GO:0140715]	GO:0000049; GO:0000166; GO:0004828; GO:0005739; GO:0005759; GO:0070158; GO:0140715; GO:0140733
GN006416	GN006416.1	D2H3M0	24.3	766	1163	982	1.76e-44	179	TDRD5_AILME	Tudor domain-containing protein 5	Ailuropoda melanoleuca (Giant panda)	P granule organization [GO:0030719]; spermatid development [GO:0007286]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]		chromatoid body [GO:0033391]; pi-body [GO:0071546]	GO:0007286; GO:0030719; GO:0033391; GO:0071546; GO:0141196
GN006417	GN006417.1	D4A6D7	29.7	313	309	365	8.01e-34	130	TTC19_RAT	Tetratricopeptide repeat protein 19, mitochondrial (TPR repeat protein 19)	Rattus norvegicus (Rat)	mitochondrial respiratory chain complex III assembly [GO:0034551]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0034551
GN006418	GN006418.1	Q9PUB8	52.3	398	525	444	2.85e-99	310	S39A7_DANRE	Zinc transporter Slc39a7 (Histidine-rich membrane protein Ke4) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7)	Danio rerio (Zebrafish) (Brachydanio rerio)	B cell differentiation [GO:0030183]; intracellular zinc ion homeostasis [GO:0006882]; regulation of ferroptosis [GO:0110075]; skin epidermis development [GO:0098773]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	zinc ion transmembrane transporter activity [GO:0005385]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	GO:0005385; GO:0005789; GO:0005794; GO:0006829; GO:0006882; GO:0030183; GO:0071577; GO:0098773; GO:0110075
GN006422	GN006422.1	A4IGL7	34.1	574	638	1457	1.44e-81	284	PXDN_XENTR	Peroxidasin (EC 1.11.2.-) [Cleaved into: PXDN active fragment]	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	angiogenesis [GO:0001525]; basement membrane assembly [GO:0070831]; basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; response to oxidative stress [GO:0006979]	heme binding [GO:0020037]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]	basement membrane [GO:0005604]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]	GO:0001525; GO:0004601; GO:0005604; GO:0005783; GO:0006979; GO:0007155; GO:0009986; GO:0016684; GO:0020037; GO:0031012; GO:0051260; GO:0070207; GO:0070831; GO:0071711
GN006423	GN006423.1	Q7QH73	37.7	591	683	767	2.47e-96	317	PERC_ANOGA	Chorion peroxidase (EC 1.11.1.7)	Anopheles gambiae (African malaria mosquito)	cellular process involved in reproduction in multicellular organism [GO:0022412]; response to oxidative stress [GO:0006979]	heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; peroxidase activity [GO:0004601]	extracellular region [GO:0005576]	GO:0004601; GO:0005576; GO:0006979; GO:0020037; GO:0022412; GO:0140825
GN006424	GN006424.1	A4IGL7	35.1	268	264	1457	2.63e-38	145	PXDN_XENTR	Peroxidasin (EC 1.11.2.-) [Cleaved into: PXDN active fragment]	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	angiogenesis [GO:0001525]; basement membrane assembly [GO:0070831]; basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; response to oxidative stress [GO:0006979]	heme binding [GO:0020037]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]	basement membrane [GO:0005604]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]	GO:0001525; GO:0004601; GO:0005604; GO:0005783; GO:0006979; GO:0007155; GO:0009986; GO:0016684; GO:0020037; GO:0031012; GO:0051260; GO:0070207; GO:0070831; GO:0071711
GN006425	GN006425.1	A0A1Y9G8H0	41.8	91	325	592	6.07e-15	79.0	PERO_ANOAL	Salivary peroxidase/catechol oxidase (EC 1.10.3.1) (EC 1.11.1.-)	Anopheles albimanus (New world malaria mosquito)	cellular process involved in reproduction in multicellular organism [GO:0022412]; response to oxidative stress [GO:0006979]	catechol oxidase activity [GO:0004097]; heme binding [GO:0020037]; peroxidase activity [GO:0004601]	extracellular region [GO:0005576]	GO:0004097; GO:0004601; GO:0005576; GO:0006979; GO:0020037; GO:0022412
GN006431	GN006431.1	B0KWH8	56.3	1149	1438	1600	0.0	1293	THOC2_CALJA	THO complex subunit 2 (Tho2)	Callithrix jacchus (White-tufted-ear marmoset) (Simia Jacchus)	generation of neurons [GO:0048699]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; neuron development [GO:0048666]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; THO complex part of transcription export complex [GO:0000445]	GO:0000445; GO:0003729; GO:0005634; GO:0005737; GO:0006397; GO:0006406; GO:0016607; GO:0048666; GO:0048699
GN006433	GN006433.1	P70581	48.0	319	689	585	1.00e-70	244	NUP58_RAT	Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1)	Rattus norvegicus (Rat)	nucleocytoplasmic transport [GO:0006913]; regulation of protein import into nucleus [GO:0042306]	identical protein binding [GO:0042802]; nuclear localization sequence binding [GO:0008139]; protein-containing complex binding [GO:0044877]; structural constituent of nuclear pore [GO:0017056]	nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; protein-containing complex [GO:0032991]	GO:0005635; GO:0005643; GO:0006913; GO:0008139; GO:0017056; GO:0031965; GO:0032991; GO:0042306; GO:0042802; GO:0044877
GN006434	GN006434.1	Q5F452	57.9	544	787	629	3.53e-227	653	MTMR8_CHICK	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8 (EC 3.1.3.95) (Myotubularin-related protein 8) (Phosphatidylinositol-3-phosphate phosphatase)	Gallus gallus (Chicken)	phosphatidylinositol dephosphorylation [GO:0046856]	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [GO:0052629]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]	nuclear envelope [GO:0005635]	GO:0004438; GO:0005635; GO:0046856; GO:0052629
GN006435	GN006435.1	O75808	50.2	683	1216	1086	1.86e-218	662	CAN15_HUMAN	Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog)	Homo sapiens (Human)	brain development [GO:0007420]; cell adhesion [GO:0007155]; proteolysis [GO:0006508]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type peptidase activity [GO:0008234]	cytoplasm [GO:0005737]	GO:0004198; GO:0005737; GO:0006508; GO:0007155; GO:0007420; GO:0008234
GN006436	GN006436.1	O75808	50.6	162	192	1086	4.82e-42	153	CAN15_HUMAN	Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog)	Homo sapiens (Human)	brain development [GO:0007420]; cell adhesion [GO:0007155]; proteolysis [GO:0006508]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type peptidase activity [GO:0008234]	cytoplasm [GO:0005737]	GO:0004198; GO:0005737; GO:0006508; GO:0007155; GO:0007420; GO:0008234
GN006440	GN006440.1	A0A1B0GTI8	28.6	140	288	187	4.70e-16	77.8	TM272_HUMAN	Transmembrane protein 272	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN006442	GN006442.1	Q8K0U4	32.3	610	574	675	1.09e-79	267	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN006443	GN006443.1	P18293	32.3	167	172	1057	7.02e-23	97.8	ANPRA_MOUSE	Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)	Mus musculus (Mouse)	cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	ANPR-A receptor complex [GO:1990620]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005789; GO:0005886; GO:0006182; GO:0007166; GO:0007168; GO:0008217; GO:0016020; GO:0016941; GO:0017046; GO:0031965; GO:0035556; GO:0042417; GO:0042562; GO:0043114; GO:0043235; GO:0048662; GO:1990620
GN006444	GN006444.1	Q8K0U4	29.4	350	350	675	5.48e-38	147	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN006457	GN006457.1	Q291A0	45.9	74	155	166	2.86e-14	69.3	RM41_DROPS	Large ribosomal subunit protein mL41 (39S ribosomal protein L41, mitochondrial) (L41mt) (MRP-L41)	Drosophila pseudoobscura pseudoobscura (Fruit fly)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; ribonucleoprotein complex [GO:1990904]	GO:0003735; GO:0005739; GO:0005762; GO:0006412; GO:1990904
GN006459	GN006459.1	Q96SJ8	27.6	196	275	248	9.84e-09	58.2	TSN18_HUMAN	Tetraspanin-18 (Tspan-18)	Homo sapiens (Human)	calcium-ion regulated exocytosis [GO:0017156]; calcium-mediated signaling [GO:0019722]; inflammatory response [GO:0006954]; protein localization to cell periphery [GO:1990778]; regulation of sprouting angiogenesis [GO:1903670]; regulation of store-operated calcium entry [GO:2001256]	transmembrane transporter binding [GO:0044325]	cell periphery [GO:0071944]; plasma membrane [GO:0005886]	GO:0005886; GO:0006954; GO:0017156; GO:0019722; GO:0044325; GO:0071944; GO:1903670; GO:1990778; GO:2001256
GN006476	GN006476.1	D4A7U2	25.7	284	478	587	4.62e-15	81.3	CARTF_RAT	Calcium-responsive transcription factor (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) (Calcium-response factor) (CaRF)	Rattus norvegicus (Rat)	cellular response to calcium ion [GO:0071277]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	granular component [GO:0001652]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0001652; GO:0003677; GO:0005634; GO:0006357; GO:0045944; GO:0071277
GN006481	GN006481.1	A1A4P5	58.6	133	138	154	6.18e-46	149	PFD2_BOVIN	Prefoldin subunit 2	Bos taurus (Bovine)		protein folding chaperone [GO:0044183]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]	GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0016272; GO:0044183
GN006482	GN006482.1	Q9DED6	73.0	89	181	247	6.88e-34	123	BAX1B_CHICK	Homeobox protein BarH-like 1b (Bar class homeoprotein Barx1b)	Gallus gallus (Chicken)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634; GO:0006357
GN006484	GN006484.1	A8WHP3	50.0	646	652	657	1.52e-226	647	SC5A9_DANRE	Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9)	Danio rerio (Zebrafish) (Brachydanio rerio)		carbohydrate:monoatomic cation symporter activity [GO:0005402]; hexose transmembrane transporter activity [GO:0015149]; solute:sodium symporter activity [GO:0015370]; transmembrane transporter activity [GO:0022857]	plasma membrane [GO:0005886]	GO:0005402; GO:0005886; GO:0015149; GO:0015370; GO:0022857
GN006485	GN006485.1	Q2TBW5	23.9	364	378	399	4.77e-19	91.3	ZNHI2_BOVIN	Zinc finger HIT domain-containing protein 2	Bos taurus (Bovine)				
GN006486	GN006486.1	Q32LN4	40.9	545	558	549	3.38e-92	296	CFA45_BOVIN	Cilia- and flagella-associated protein 45	Bos taurus (Bovine)	establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]	AMP binding [GO:0016208]	9+0 motile cilium [GO:0097728]; axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; sperm end piece [GO:0097229]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0005879; GO:0016208; GO:0030317; GO:0036126; GO:0061966; GO:0097225; GO:0097228; GO:0097229; GO:0097728; GO:0160112
GN006487	GN006487.1	Q9VUJ0	40.9	232	241	333	3.52e-51	172	RM39_DROME	Large ribosomal subunit protein mL39 (39S ribosomal protein L39, mitochondrial) (MRP-L39) (MRP-L5)	Drosophila melanogaster (Fruit fly)	mitochondrial translation [GO:0032543]	nucleotide binding [GO:0000166]; structural constituent of ribosome [GO:0003735]	mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0000166; GO:0003735; GO:0005739; GO:0005762; GO:0032543
GN006488	GN006488.1	Q9ERU9	30.5	1206	1738	3053	5.27e-101	365	RBP2_MOUSE	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (Ran-binding protein 2) (RanBP2)	Mus musculus (Mouse)	centrosome localization [GO:0051642]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; negative regulation of innate immune response [GO:0045824]; negative regulation of RNA export from nucleus [GO:0046832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear export [GO:0051168]; nucleocytoplasmic transport [GO:0006913]; protein folding [GO:0006457]; protein sumoylation [GO:0016925]; regulation of gluconeogenesis [GO:0006111]; response to amphetamine [GO:0001975]; toll-like receptor signaling pathway [GO:0002224]	kinase activator activity [GO:0019209]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]	annulate lamellae [GO:0005642]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SUMO ligase complex [GO:0106068]	GO:0000122; GO:0001975; GO:0002224; GO:0002753; GO:0003755; GO:0005634; GO:0005635; GO:0005642; GO:0005643; GO:0005654; GO:0005829; GO:0006111; GO:0006457; GO:0006607; GO:0006913; GO:0016925; GO:0019209; GO:0019789; GO:0030674; GO:0031267; GO:0031965; GO:0042405; GO:0044614; GO:0044615; GO:0044877; GO:0045824; GO:0046832; GO:0051168; GO:0051642; GO:0061665; GO:0106068; GO:1990723
GN006489	GN006489.1	Q99666	26.6	642	793	1765	5.75e-44	176	RGPD5_HUMAN	RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63)	Homo sapiens (Human)	NLS-bearing protein import into nucleus [GO:0006607]; nuclear export [GO:0051168]	SUMO transferase activity [GO:0019789]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]	GO:0005643; GO:0005737; GO:0006607; GO:0019789; GO:0051168
GN006490	GN006490.1	Q61206	53.4	223	235	229	3.58e-82	248	PA1B2_MOUSE	Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta)	Mus musculus (Mouse)	positive regulation of macroautophagy [GO:0016239]; spermatogenesis [GO:0007283]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; identical protein binding [GO:0042802]; platelet-activating factor acetyltransferase activity [GO:0047179]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	1-alkyl-2-acetylglycerophosphocholine esterase complex [GO:0008247]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	GO:0001650; GO:0003847; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0007283; GO:0008247; GO:0016239; GO:0042802; GO:0042803; GO:0044877; GO:0046982; GO:0047179
GN006499	GN006499.1	P70704	61.1	1172	1169	1164	0.0	1398	AT8A1_MOUSE	Phospholipid-transporting ATPase IA (EC 7.6.2.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1)	Mus musculus (Mouse)	aminophospholipid translocation [GO:0140331]; learning [GO:0007612]; phospholipid translocation [GO:0045332]; positive regulation of cell migration [GO:0030335]; positive regulation of phospholipid translocation [GO:0061092]; synaptic vesicle endocytosis [GO:0048488]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; magnesium ion binding [GO:0000287]; phosphatidylserine flippase activity [GO:0140346]; phosphatidylserine floppase activity [GO:0090556]	chromaffin granule membrane [GO:0042584]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; organelle membrane [GO:0031090]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]	GO:0000287; GO:0005524; GO:0005783; GO:0005794; GO:0005802; GO:0005829; GO:0005886; GO:0007612; GO:0012505; GO:0016887; GO:0030335; GO:0030672; GO:0031090; GO:0031410; GO:0042584; GO:0045202; GO:0045332; GO:0048488; GO:0061092; GO:0090556; GO:0098978; GO:0140326; GO:0140331; GO:0140346; GO:1990531
GN006500	GN006500.1	Q5XJQ5	57.1	350	751	393	2.18e-131	398	EXOS9_DANRE	Exosome complex component RRP45 (Exosome component 9)	Danio rerio (Zebrafish) (Brachydanio rerio)	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; rRNA catabolic process [GO:0016075]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]	mRNA 3'-UTR AU-rich region binding [GO:0035925]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000176; GO:0000177; GO:0000467; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0016075; GO:0034473; GO:0034475; GO:0034476; GO:0035925; GO:0071028; GO:0071035; GO:0071038
GN006501	GN006501.1	P04962	60.0	420	430	422	1.44e-153	444	CCNA_SPISO	G2/mitotic-specific cyclin-A	Spisula solidissima (Atlantic surf-clam)	mitotic cell cycle phase transition [GO:0044772]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]		GO:0016538; GO:0044772
GN006502	GN006502.1	Q15319	52.7	349	332	338	1.68e-93	284	PO4F3_HUMAN	POU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3C) (Brain-3C) (Brn-3C)	Homo sapiens (Human)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0007601; GO:0007605; GO:0045944; GO:0090575; GO:1990837
GN006503	GN006503.1	Q3UMC0	44.6	847	864	893	4.00e-231	676	AFG2A_MOUSE	ATPase family gene 2 protein homolog A (EC 3.6.4.10) (AFG2 AAA ATPase homolog A) (Ribosome biogenesis protein SPATA5) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5)	Mus musculus (Mouse)	brain development [GO:0007420]; DNA replication [GO:0006260]; regulation of ribosome biogenesis [GO:0090069]; ribosomal large subunit biogenesis [GO:0042273]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275]	ATPase complex [GO:1904949]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005819; GO:0005829; GO:0006260; GO:0007420; GO:0016887; GO:0042273; GO:0090069; GO:1904949; GO:1990275
GN006504	GN006504.1	Q5VWW1	34.3	134	183	255	1.39e-09	58.9	C1QL3_HUMAN	Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0097107; GO:0098686; GO:0098978; GO:0099550; GO:0099558; GO:0099645
GN006505	GN006505.1	Q86Z23	37.1	116	119	238	2.34e-12	64.3	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN006506	GN006506.1	O09172	44.6	157	174	274	1.13e-42	146	GSH0_MOUSE	Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit)	Mus musculus (Mouse)	apoptotic mitochondrial changes [GO:0008637]; blood vessel diameter maintenance [GO:0097746]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to thyroxine stimulus [GO:0097069]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione metabolic process [GO:0006749]; hepatic stellate cell activation [GO:0035733]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to human chorionic gonadotropin [GO:0044752]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]	glutamate-cysteine ligase activity [GO:0004357]; glutamate-cysteine ligase catalytic subunit binding [GO:0035226]; glutamate-cysteine ligase regulator activity [GO:1990609]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]	glutamate-cysteine ligase complex [GO:0017109]	GO:0004357; GO:0006536; GO:0006749; GO:0006750; GO:0006979; GO:0007584; GO:0008637; GO:0009410; GO:0014823; GO:0017109; GO:0035226; GO:0035729; GO:0035733; GO:0043524; GO:0044344; GO:0044752; GO:0044877; GO:0046982; GO:0051409; GO:0051900; GO:0071333; GO:0071372; GO:0097069; GO:0097746; GO:1990609; GO:1990830; GO:2001237
GN006509	GN006509.1	Q9NPB8	35.7	655	677	672	6.88e-123	383	GPCP1_HUMAN	Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5)	Homo sapiens (Human)	glycerophospholipid catabolic process [GO:0046475]	glycerophosphocholine phosphodiesterase activity [GO:0047389]; starch binding [GO:2001070]	cytoplasm [GO:0005737]	GO:0005737; GO:0046475; GO:0047389; GO:2001070
GN006516	GN006516.1	O00311	41.8	534	514	574	1.22e-117	361	CDC7_HUMAN	Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1)	Homo sapiens (Human)	cell cycle phase transition [GO:0044770]; double-strand break repair via break-induced replication [GO:0000727]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]	ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; Dbf4-dependent protein kinase complex [GO:0031431]; intercellular bridge [GO:0045171]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000082; GO:0000727; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0008284; GO:0010571; GO:0010971; GO:0016301; GO:0031431; GO:0031573; GO:0033314; GO:0044770; GO:0045171; GO:0072686; GO:0106310
GN006517	GN006517.1	Q8K0U4	30.7	661	580	675	4.17e-71	244	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN006518	GN006518.1	Q8K0U4	30.4	631	593	675	7.96e-70	241	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN006519	GN006519.1	Q4ZJM9	28.6	140	269	238	6.20e-09	58.5	C1QL4_MOUSE	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11)	Mus musculus (Mouse)	maintenance of synapse structure [GO:0099558]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular region [GO:0005576]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0005576; GO:0042802; GO:0043083; GO:0045202; GO:0045599; GO:0048147; GO:0070373; GO:0099550; GO:0099558
GN006520	GN006520.1	P86437	30.9	136	245	193	2.15e-10	61.6	CBLN1_BOVIN	Cerebellin-1 (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin]	Bos taurus (Bovine)	cerebellar granule cell differentiation [GO:0021707]; heterophilic cell-cell adhesion [GO:0007157]; maintenance of synapse structure [GO:0099558]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of inhibitory synapse assembly [GO:1905703]; positive regulation of long-term synaptic depression [GO:1900454]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synapse organization [GO:0050808]; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission [GO:0099557]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]; signaling receptor regulator activity [GO:0030545]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic membrane [GO:0045211]; synaptic cleft [GO:0043083]; trans-synaptic protein complex [GO:0098820]	GO:0005576; GO:0007157; GO:0021707; GO:0030545; GO:0042802; GO:0043083; GO:0045211; GO:0050808; GO:0090394; GO:0098688; GO:0098820; GO:0098978; GO:0099151; GO:0099550; GO:0099557; GO:0099558; GO:1900454; GO:1905606; GO:1905703
GN006522	GN006522.1	Q5VWW1	38.8	129	143	255	1.58e-13	68.6	C1QL3_HUMAN	Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0097107; GO:0098686; GO:0098978; GO:0099550; GO:0099558; GO:0099645
GN006526	GN006526.1	O75445	29.5	404	418	5202	1.64e-50	187	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN006528	GN006528.1	Q8WXX0	67.0	4020	3958	4024	0.0	5447	DYH7_HUMAN	Dynein axonemal heavy chain 7 (Axonemal beta dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (hDHC2)	Homo sapiens (Human)	cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; inner dynein arm assembly [GO:0036159]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; cilium [GO:0005929]; inner dynein arm [GO:0036156]; sperm annulus [GO:0097227]; sperm midpiece [GO:0097225]	GO:0003341; GO:0003777; GO:0005509; GO:0005524; GO:0005858; GO:0005929; GO:0008569; GO:0036156; GO:0036159; GO:0045505; GO:0051959; GO:0060285; GO:0060294; GO:0097225; GO:0097227; GO:0097729
GN006529	GN006529.1	Q7TNH6	65.2	204	408	1325	1.60e-36	145	NPHP3_MOUSE	Nephrocystin-3	Mus musculus (Mouse)	atrial septum development [GO:0003283]; cilium assembly [GO:0060271]; convergent extension [GO:0060026]; convergent extension involved in gastrulation [GO:0060027]; determination of intestine left/right asymmetry [GO:0071908]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; determination of stomach left/right asymmetry [GO:0071909]; establishment or maintenance of cell polarity [GO:0007163]; extracellular matrix organization [GO:0030198]; heart looping [GO:0001947]; kidney development [GO:0001822]; kidney morphogenesis [GO:0060993]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; maintenance of animal organ identity [GO:0048496]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; non-motile cilium assembly [GO:1905515]; photoreceptor cell maintenance [GO:0045494]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; ureter development [GO:0072189]		ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; ciliary tip [GO:0097542]; cilium [GO:0005929]	GO:0001822; GO:0001947; GO:0003283; GO:0005929; GO:0006629; GO:0007163; GO:0007368; GO:0030198; GO:0030324; GO:0035469; GO:0045494; GO:0048496; GO:0060026; GO:0060027; GO:0060271; GO:0060993; GO:0071908; GO:0071909; GO:0071910; GO:0072189; GO:0090090; GO:0097542; GO:0097543; GO:0097546; GO:1905515; GO:2000095
GN006530	GN006530.1	P54353	60.7	140	129	166	2.63e-52	165	DOD_DROME	Putative peptidyl-prolyl cis-trans isomerase dodo (PPIase dodo) (EC 5.2.1.8) (Rotamase dodo)	Drosophila melanogaster (Fruit fly)	positive regulation of protein ubiquitination [GO:0031398]; regulation of locomotor rhythm [GO:1904059]	DNA-binding transcription factor binding [GO:0140297]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003755; GO:0005634; GO:0005829; GO:0031398; GO:0140297; GO:1904059
GN006531	GN006531.1	Q96CN4	42.5	605	917	794	1.15e-122	394	EVI5L_HUMAN	EVI5-like protein (Ecotropic viral integration site 5-like protein)	Homo sapiens (Human)	negative regulation of cilium assembly [GO:1902018]; positive regulation of GTPase activity [GO:0043547]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]		GO:0005096; GO:0031267; GO:0043547; GO:1902018
GN006533	GN006533.1	Q8K389	59.0	78	580	1822	7.65e-18	91.7	CK5P2_MOUSE	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48)	Mus musculus (Mouse)	brain development [GO:0007420]; centriole replication [GO:0007099]; centrosome cycle [GO:0007098]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule organizing center organization [GO:0031023]; negative regulation of centriole replication [GO:0046600]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of neuron differentiation [GO:0045665]; neurogenesis [GO:0022008]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	calmodulin binding [GO:0005516]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; transcription cis-regulatory region binding [GO:0000976]; tubulin binding [GO:0015631]	cell junction [GO:0030054]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; gamma-tubulin ring complex [GO:0000931]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule plus-end [GO:0035371]; mitotic spindle pole [GO:0097431]; pericentriolar material [GO:0000242]; perinuclear region of cytoplasm [GO:0048471]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; spindle pole [GO:0000922]	GO:0000132; GO:0000226; GO:0000242; GO:0000922; GO:0000931; GO:0000976; GO:0001578; GO:0005516; GO:0005737; GO:0005794; GO:0005813; GO:0005829; GO:0005874; GO:0007059; GO:0007098; GO:0007099; GO:0007420; GO:0008017; GO:0015631; GO:0019901; GO:0022008; GO:0030054; GO:0031023; GO:0031116; GO:0035371; GO:0036064; GO:0043015; GO:0044877; GO:0045665; GO:0045736; GO:0045893; GO:0046600; GO:0048471; GO:0090266; GO:0097225; GO:0097228; GO:0097431
GN006534	GN006534.1	Q5VU43	25.7	393	1205	2346	1.16e-11	73.6	MYOME_HUMAN	Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein)	Homo sapiens (Human)	astral microtubule organization [GO:0030953]; centrosome cycle [GO:0007098]; positive regulation of microtubule nucleation [GO:0090063]; protein-containing complex assembly [GO:0065003]; regulation of Golgi organization [GO:1903358]	enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; myofibril [GO:0030016]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005794; GO:0005813; GO:0007098; GO:0019899; GO:0030016; GO:0030953; GO:0060090; GO:0065003; GO:0090063; GO:1903358
GN006535	GN006535.1	Q17QS4	33.1	390	446	396	1.27e-61	208	PI5L1_BOVIN	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PI(4)P 5-kinase-like protein 1) (PtdIns(4)P-5-kinase-like protein 1)	Bos taurus (Bovine)	negative regulation of mitochondrial membrane potential [GO:0010917]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of apoptotic process [GO:0043065]	phosphatidylinositol kinase activity [GO:0052742]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0005737; GO:0010917; GO:0016020; GO:0043065; GO:0046488; GO:0046854; GO:0052742
GN006536	GN006536.1	Q8CAE2	36.0	278	396	395	7.94e-54	186	HENMT_MOUSE	Small RNA 2'-O-methyltransferase (EC 2.1.1.386) (HEN1 methyltransferase homolog 1) (mHEN1)	Mus musculus (Mouse)	piRNA processing [GO:0034587]; RNA methylation [GO:0001510]	O-methyltransferase activity [GO:0008171]; RNA methyltransferase activity [GO:0008173]; small RNA 2'-O-ribose methyltransferase activity [GO:0090486]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; P granule [GO:0043186]	GO:0001510; GO:0005737; GO:0005829; GO:0008171; GO:0008173; GO:0034587; GO:0043186; GO:0090486
GN006539	GN006539.1	A9JS51	41.6	298	297	311	2.04e-70	223	CMI2B_XENLA	Ciliary microtubule inner protein 2B	Xenopus laevis (African clawed frog)			axonemal microtubule [GO:0005879]	GO:0005879
GN006540	GN006540.1	Q8I719	28.3	173	645	853	1.09e-12	75.1	KGP_PLAF7	cGMP-dependent protein kinase (EC 2.7.11.12) (PfPKG)	Plasmodium falciparum (isolate 3D7)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; gamete generation [GO:0007276]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; cGMP-dependent protein kinase activity [GO:0004692]; protein serine kinase activity [GO:0106310]	cAMP-dependent protein kinase complex [GO:0005952]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of membrane [GO:0019898]	GO:0004691; GO:0004692; GO:0005524; GO:0005737; GO:0005783; GO:0005789; GO:0005952; GO:0006468; GO:0007189; GO:0007276; GO:0019898; GO:0106310
GN006550	GN006550.1	E1B8W3	52.2	1096	1072	1044	2.64e-184	567	ODAD2_BOVIN	Outer dynein arm-docking complex subunit 2 (Armadillo repeat-containing protein 4)	Bos taurus (Bovine)	cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]		outer dynein arm docking complex [GO:0120228]	GO:0003341; GO:0036158; GO:0120228
GN006552	GN006552.1	P49870	57.8	346	665	360	7.37e-131	392	HR38_BOMMO	Probable nuclear hormone receptor HR38 (bHR38) (Nuclear receptor subfamily 4 group A member 4)	Bombyx mori (Silk moth)	cellular response to corticotropin-releasing hormone stimulus [GO:0071376]	nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000978; GO:0004879; GO:0005634; GO:0005667; GO:0008270; GO:0035259; GO:0071376
GN006555	GN006555.1	Q99612	41.5	147	302	283	6.32e-17	82.4	KLF6_HUMAN	Krueppel-like factor 6 (B-cell-derived protein 1) (Core promoter element-binding protein) (GC-rich sites-binding factor GBF) (Proto-oncogene BCD1) (Suppressor of tumorigenicity 12 protein) (Transcription factor Zf9)	Homo sapiens (Human)	B cell differentiation [GO:0030183]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0001650; GO:0005634; GO:0005654; GO:0005730; GO:0006357; GO:0030183; GO:0045893; GO:0045944; GO:1990837
GN006556	GN006556.1	P15043	36.9	84	110	609	4.40e-10	58.5	RECQ_ECOLI	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Escherichia coli (strain K12)	DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; G-quadruplex unwinding activity [GO:0160225]; single-stranded DNA helicase activity [GO:0017116]; transition metal ion binding [GO:0046914]; zinc ion binding [GO:0008270]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]; single-stranded DNA-dependent ATP-dependent DNA helicase complex [GO:0017117]	GO:0003677; GO:0003678; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0006974; GO:0008094; GO:0008270; GO:0009432; GO:0016887; GO:0017116; GO:0017117; GO:0030894; GO:0043138; GO:0043590; GO:0046914; GO:0160225
GN006558	GN006558.1	Q5AXT5	30.6	291	288	745	1.27e-37	144	PIF1_EMENI	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]	GO:0000723; GO:0003697; GO:0005524; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0043139; GO:0043596; GO:0071932
GN006561	GN006561.1	Q6U841	47.2	1126	1109	1118	3.31e-311	898	S4A10_HUMAN	Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10)	Homo sapiens (Human)	bicarbonate transport [GO:0015701]; chloride transport [GO:0006821]; regulation of intracellular pH [GO:0051453]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; visual perception [GO:0007601]	sodium,bicarbonate:chloride antiporter activity [GO:0140892]; sodium:bicarbonate symporter activity [GO:0008510]; solute:inorganic anion antiporter activity [GO:0005452]	apical dendrite [GO:0097440]; apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; basal dendrite [GO:0097441]; basolateral plasma membrane [GO:0016323]; CA3 pyramidal cell dendrite [GO:0097442]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; somatodendritic compartment [GO:0036477]; synapse [GO:0045202]	GO:0005452; GO:0005886; GO:0006821; GO:0007601; GO:0008510; GO:0015701; GO:0016020; GO:0016323; GO:0016324; GO:0030425; GO:0036477; GO:0043025; GO:0043204; GO:0043679; GO:0045202; GO:0048172; GO:0051453; GO:0097440; GO:0097441; GO:0097442; GO:0098793; GO:0098794; GO:0098982; GO:0140892
GN006562	GN006562.1	Q9UUA2	32.0	194	461	805	2.74e-13	75.9	PIF1_SCHPO	ATP-dependent DNA helicase pfh1 (EC 5.6.2.3) (DNA 5'-3' helicase pfh1) (DNA repair and recombination helicase pfh1) (PIF1 helicase homolog) (RRM3/PIF1 homolog 1)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand elongation involved in mitotic DNA replication [GO:1902983]; mitochondrial DNA repair [GO:0043504]; mitotic recombination-dependent replication fork processing [GO:1990426]; removal of RNA primer involved in mitotic DNA replication [GO:1903469]; replication fork processing [GO:0031297]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; 5'-3' DNA/RNA helicase activity [GO:0033678]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein-DNA complex displacement activity [GO:0061995]; DNA/DNA annealing activity [GO:1990814]; flap-structured DNA binding [GO:0070336]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex unwinding activity [GO:0160225]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]	chromatin [GO:0000785]; chromosome, telomeric repeat region [GO:0140445]; mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; nuclear replisome [GO:0043601]; nucleolus [GO:0005730]; nucleus [GO:0005634]; rDNA heterochromatin [GO:0033553]; site of double-strand break [GO:0035861]	GO:0000723; GO:0000785; GO:0003697; GO:0003723; GO:0005524; GO:0005634; GO:0005730; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0017116; GO:0031297; GO:0033553; GO:0033678; GO:0035861; GO:0043139; GO:0043504; GO:0043596; GO:0043601; GO:0051880; GO:0061995; GO:0070336; GO:0071932; GO:0140445; GO:0160225; GO:1902983; GO:1903469; GO:1990426; GO:1990814
GN006569	GN006569.1	Q9Y426	25.6	528	706	696	5.06e-25	114	C2CD2_HUMAN	C2 domain-containing protein 2 (Transmembrane protein 24-like)	Homo sapiens (Human)			cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0016020
GN006570	GN006570.1	A2AX52	31.6	136	456	2309	6.58e-14	78.2	CO6A4_MOUSE	Collagen alpha-4(VI) chain	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]	collagen binding [GO:0005518]	collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991]	GO:0005518; GO:0005576; GO:0005589; GO:0030198; GO:0031012; GO:0032991
GN006571	GN006571.1	Q0GC71	27.1	328	347	784	2.56e-22	101	TLR2_CAPHI	Toll-like receptor 2 (CD antigen CD282)	Capra hircus (Goat)	cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; immune response [GO:0006955]; inflammatory response [GO:0006954]; toll-like receptor signaling pathway [GO:0002224]	transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0002224; GO:0004888; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0016020; GO:0030670; GO:0042497; GO:0043235; GO:0045121; GO:0071726; GO:0071727
GN006573	GN006573.1	Q92759	59.6	458	468	462	4.93e-191	542	TF2H4_HUMAN	General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit)	Homo sapiens (Human)	DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	ATPase activator activity [GO:0001671]; double-stranded DNA binding [GO:0003690]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	core TFIIH complex portion of holo TFIIH complex [GO:0000438]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]	GO:0000438; GO:0000439; GO:0001671; GO:0003690; GO:0005634; GO:0005654; GO:0005669; GO:0005675; GO:0006281; GO:0006289; GO:0006366; GO:0006367; GO:0016251; GO:0016607
GN006575	GN006575.1	O14530	55.5	220	221	226	2.57e-80	242	TXND9_HUMAN	Thioredoxin domain-containing protein 9 (ATP-binding protein associated with cell differentiation) (Protein 1-4)	Homo sapiens (Human)	microtubule cytoskeleton organization [GO:0000226]	cadherin binding [GO:0045296]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634]	GO:0000226; GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0030496; GO:0045296
GN006576	GN006576.1	Q08890	49.8	492	500	552	8.65e-170	493	IDS_MOUSE	Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase)	Mus musculus (Mouse)	dermatan sulfate proteoglycan catabolic process [GO:0030209]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]	calcium ion binding [GO:0005509]; iduronate-2-sulfatase activity [GO:0004423]; sulfuric ester hydrolase activity [GO:0008484]	lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	GO:0004423; GO:0005509; GO:0005764; GO:0006027; GO:0008484; GO:0030200; GO:0030209; GO:0043202
GN006580	GN006580.1	Q921S7	34.1	91	254	423	1.43e-09	61.2	RM37_MOUSE	Large ribosomal subunit protein mL37 (39S ribosomal protein L37, mitochondrial) (L37mt) (MRP-L37)	Mus musculus (Mouse)	mitochondrial translation [GO:0032543]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005761; GO:0005762; GO:0032543
GN006581	GN006581.1	Q6P4S6	44.9	755	1057	1369	2.63e-158	507	SIK3_MOUSE	Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)	Mus musculus (Mouse)	cartilage development involved in endochondral bone morphogenesis [GO:0060351]; endochondral ossification [GO:0001958]; intracellular signal transduction [GO:0035556]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; multicellular organism growth [GO:0035264]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein phosphorylation [GO:0006468]; regulation of protein localization [GO:0032880]; skeletal system morphogenesis [GO:0048705]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]	cytoplasm [GO:0005737]	GO:0000226; GO:0000287; GO:0001958; GO:0004674; GO:0005524; GO:0005737; GO:0006468; GO:0032880; GO:0035108; GO:0035264; GO:0035556; GO:0048705; GO:0050321; GO:0060351; GO:0106310; GO:1904263; GO:1904515
GN006583	GN006583.1	Q0EEE2	27.9	857	956	906	3.73e-88	305	PTHD3_MOUSE	Patched domain-containing protein 3 (RND-type protein RNDEu-3)	Mus musculus (Mouse)			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sperm midpiece [GO:0097225]	GO:0005783; GO:0005789; GO:0016020; GO:0097225
GN006584	GN006584.1	Q0EEE2	28.0	857	956	906	5.14e-88	304	PTHD3_MOUSE	Patched domain-containing protein 3 (RND-type protein RNDEu-3)	Mus musculus (Mouse)			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sperm midpiece [GO:0097225]	GO:0005783; GO:0005789; GO:0016020; GO:0097225
GN006585	GN006585.1	A0A1V6PAF7	43.2	118	125	2910	5.31e-26	104	CALA_PENDC	Highly reducing polyketide synthase calA (HR-PKS calA) (EC 2.3.1.-) (Calbistrin biosynthesis cluster protein A)	Penicillium decumbens	fatty acid biosynthetic process [GO:0006633]; lactone biosynthetic process [GO:1901336]; polyketide biosynthetic process [GO:0030639]	3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; fatty acid synthase activity [GO:0004312]; phosphopantetheine binding [GO:0031177]		GO:0004312; GO:0004315; GO:0006633; GO:0030639; GO:0031177; GO:1901336
GN006586	GN006586.1	Q869W9	24.1	854	932	2603	4.98e-44	177	PKS16_DICDI	Probable polyketide synthase 16 (dipks16) (EC 2.3.1.-)	Dictyostelium discoideum (Social amoeba)	fatty acid biosynthetic process [GO:0006633]; mating [GO:0007618]	3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; fatty acid synthase activity [GO:0004312]; oxidoreductase activity [GO:0016491]		GO:0004312; GO:0004315; GO:0006633; GO:0007618; GO:0016491
GN006587	GN006587.1	P9WEZ4	25.8	248	253	3861	1.77e-20	94.0	PYTA_ASPTE	Hybrid PKS-NRPS synthetase pytA (EC 2.3.1.-) (EC 6.3.2.-) (Pyranterreones biosynthesis cluster protein A)	Aspergillus terreus	fatty acid biosynthetic process [GO:0006633]; lactone biosynthetic process [GO:1901336]; secondary metabolite biosynthetic process [GO:0044550]	3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; fatty acid synthase activity [GO:0004312]; oxidoreductase activity [GO:0016491]; phosphopantetheine binding [GO:0031177]		GO:0004312; GO:0004315; GO:0006633; GO:0016491; GO:0031177; GO:0044550; GO:1901336
GN006592	GN006592.1	Q3UGF1	64.7	1288	1285	1341	0.0	1713	WDR19_MOUSE	WD repeat-containing protein 19 (Intraflagellar transport 144 homolog)	Mus musculus (Mouse)	cell morphogenesis [GO:0000902]; cilium assembly [GO:0060271]; digestive system development [GO:0055123]; ear morphogenesis [GO:0042471]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; gonad development [GO:0008406]; in utero embryonic development [GO:0001701]; intraciliary anterograde transport [GO:0035720]; intraciliary retrograde transport [GO:0035721]; myotome development [GO:0061055]; nervous system process [GO:0050877]; protein localization to ciliary membrane [GO:1903441]; protein localization to cilium [GO:0061512]; protein localization to non-motile cilium [GO:0097499]; protein-containing complex assembly [GO:0065003]; receptor clustering [GO:0043113]; smoothened signaling pathway [GO:0007224]	protein carrier activity [GO:0140597]	cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0000902; GO:0001701; GO:0001750; GO:0005886; GO:0005929; GO:0007224; GO:0008406; GO:0030326; GO:0030991; GO:0031076; GO:0031514; GO:0032391; GO:0035720; GO:0035721; GO:0042471; GO:0043113; GO:0048701; GO:0050877; GO:0055123; GO:0060271; GO:0061055; GO:0061512; GO:0065003; GO:0097225; GO:0097228; GO:0097499; GO:0097730; GO:0140597; GO:1903441
GN006598	GN006598.1	P91778	44.1	374	364	508	2.01e-100	309	AMY_PECMA	Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)	Pecten maximus (King scallop) (Pilgrim's clam)	carbohydrate metabolic process [GO:0005975]	alpha-amylase activity [GO:0004556]; cation binding [GO:0043169]		GO:0004556; GO:0005975; GO:0043169
GN006599	GN006599.1	Q7JK24	41.2	260	351	326	1.13e-64	211	B3GT1_GORGO	Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)	Gorilla gorilla gorilla (Western lowland gorilla)	glucosylceramide metabolic process [GO:0006678]; glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006678; GO:0008499; GO:0009101; GO:0009312
GN006600	GN006600.1	P91778	52.9	507	702	508	1.62e-182	531	AMY_PECMA	Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)	Pecten maximus (King scallop) (Pilgrim's clam)	carbohydrate metabolic process [GO:0005975]	alpha-amylase activity [GO:0004556]; cation binding [GO:0043169]		GO:0004556; GO:0005975; GO:0043169
GN006602	GN006602.1	Q0VAA2	33.0	100	620	488	8.90e-10	65.1	LR74A_HUMAN	Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74)	Homo sapiens (Human)				
GN006603	GN006603.1	Q8J0F5	28.0	400	1059	2563	6.97e-34	145	MLCB_PENCI	Compactin diketide synthase mlcB (EC 2.3.1.244) (Compactin biosynthesis protein B)	Penicillium citrinum	fatty acid biosynthetic process [GO:0006633]; mevastatin biosynthetic process [GO:0140877]	3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; fatty acid synthase activity [GO:0004312]; oxidoreductase activity [GO:0016491]; phosphopantetheine binding [GO:0031177]		GO:0004312; GO:0004315; GO:0006633; GO:0016491; GO:0031177; GO:0140877
GN006604	GN006604.1	B0XZV6	26.2	897	1251	2514	3.60e-64	244	SPHB_ASPFC	Highly reducing polyketide synthase sphB (HR-PKS sphB) (EC 2.3.1.-) (Sphingofungin biosynthesis cluster protein B)	Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10) (Neosartorya fumigata)	fatty acid biosynthetic process [GO:0006633]; lactone biosynthetic process [GO:1901336]; secondary metabolite biosynthetic process [GO:0044550]	fatty acid synthase activity [GO:0004312]; oxidoreductase activity [GO:0016491]; phosphopantetheine binding [GO:0031177]		GO:0004312; GO:0006633; GO:0016491; GO:0031177; GO:0044550; GO:1901336
GN006605	GN006605.1	A0A0C1E3C9	31.7	252	691	2367	1.04e-15	85.5	STMA_ASPUT	Highly reducing polyketide synthase stmA (HR-PKS stmA) (EC 1.-.-.-) (EC 2.3.1.-) (Stromemycin biosynthesis cluster protein A)	Aspergillus ustus	fatty acid biosynthetic process [GO:0006633]; lactone biosynthetic process [GO:1901336]; secondary metabolite biosynthetic process [GO:0044550]	3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; fatty acid synthase activity [GO:0004312]; oxidoreductase activity [GO:0016491]; phosphopantetheine binding [GO:0031177]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; zinc ion binding [GO:0008270]		GO:0004312; GO:0004315; GO:0006633; GO:0008270; GO:0008757; GO:0016491; GO:0031177; GO:0044550; GO:1901336
GN006606	GN006606.1	Q869W9	26.7	848	1399	2603	2.16e-58	226	PKS16_DICDI	Probable polyketide synthase 16 (dipks16) (EC 2.3.1.-)	Dictyostelium discoideum (Social amoeba)	fatty acid biosynthetic process [GO:0006633]; mating [GO:0007618]	3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; fatty acid synthase activity [GO:0004312]; oxidoreductase activity [GO:0016491]		GO:0004312; GO:0004315; GO:0006633; GO:0007618; GO:0016491
GN006612	GN006612.1	Q0EEE2	28.5	861	956	906	1.08e-89	309	PTHD3_MOUSE	Patched domain-containing protein 3 (RND-type protein RNDEu-3)	Mus musculus (Mouse)			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sperm midpiece [GO:0097225]	GO:0005783; GO:0005789; GO:0016020; GO:0097225
GN006613	GN006613.1	Q9FT72	27.1	454	513	713	5.45e-34	139	RQL3_ARATH	ATP-dependent DNA helicase Q-like 3 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ3) (RecQ-like protein 3) (AtRecQ3) (AtRecQl3)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004386; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006310; GO:0009378; GO:0016887; GO:0043138; GO:1990814
GN006617	GN006617.1	Q9BX70	21.9	366	385	525	1.96e-09	62.8	BTBD2_HUMAN	BTB/POZ domain-containing protein 2	Homo sapiens (Human)	neurogenesis [GO:0022008]		cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; P-body [GO:0000932]	GO:0000932; GO:0005737; GO:0005829; GO:0022008; GO:0036464
GN006618	GN006618.1	Q3KNS1	31.6	294	405	954	2.39e-36	144	PTHD3_HUMAN	Patched domain-containing protein 3 (Patched-related protein)	Homo sapiens (Human)			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sperm midpiece [GO:0097225]	GO:0005783; GO:0005789; GO:0016020; GO:0097225
GN006622	GN006622.1	Q0EEE2	22.1	303	320	906	9.98e-13	72.4	PTHD3_MOUSE	Patched domain-containing protein 3 (RND-type protein RNDEu-3)	Mus musculus (Mouse)			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sperm midpiece [GO:0097225]	GO:0005783; GO:0005789; GO:0016020; GO:0097225
GN006624	GN006624.1	Q0EEE2	22.1	303	320	906	1.79e-12	71.6	PTHD3_MOUSE	Patched domain-containing protein 3 (RND-type protein RNDEu-3)	Mus musculus (Mouse)			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sperm midpiece [GO:0097225]	GO:0005783; GO:0005789; GO:0016020; GO:0097225
GN006630	GN006630.1	Q13627	78.4	463	805	763	5.99e-244	702	DYR1A_HUMAN	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)	Homo sapiens (Human)	circadian rhythm [GO:0007623]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of heterochromatin formation [GO:0031452]; negative regulation of microtubule polymerization [GO:0031115]; nervous system development [GO:0007399]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of RNA splicing [GO:0033120]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of amyloid-beta formation [GO:1902003]; regulation of neurofibrillary tangle assembly [GO:1902996]	actin binding [GO:0003779]; ATP binding [GO:0005524]; cytoskeletal protein binding [GO:0008092]; histone H3T45 kinase activity [GO:0140857]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; splicing factor binding [GO:1990935]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; transcription coactivator activity [GO:0003713]; tubulin binding [GO:0015631]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000381; GO:0003713; GO:0003779; GO:0004672; GO:0004674; GO:0004712; GO:0004713; GO:0004715; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006468; GO:0007399; GO:0007623; GO:0008092; GO:0008353; GO:0015631; GO:0016607; GO:0018108; GO:0030424; GO:0030425; GO:0031115; GO:0031452; GO:0033120; GO:0042802; GO:0043518; GO:0045893; GO:0046777; GO:0048156; GO:0050321; GO:0106310; GO:0140857; GO:1902003; GO:1902996; GO:1990935; GO:2000781
GN006632	GN006632.1	O01393	40.4	379	444	386	2.18e-91	285	UNC9_CAEEL	Innexin unc-9 (Uncoordinated protein 9)	Caenorhabditis elegans	monoatomic ion transmembrane transport [GO:0034220]; positive regulation of locomotion [GO:0040017]	actin filament binding [GO:0051015]; gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	cell-cell junction [GO:0005911]; gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0034220; GO:0040017; GO:0051015; GO:0055077
GN006633	GN006633.1	Q23157	30.9	272	323	465	1.44e-44	161	INX11_CAEEL	Innexin-11 (Protein opu-11)	Caenorhabditis elegans		gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005921; GO:0055077
GN006645	GN006645.1	Q9JIP0	24.8	616	905	723	1.35e-29	129	TRPV5_RAT	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transporter 2) (CaT2) (Epithelial calcium channel 1) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3)	Rattus norvegicus (Rat)	calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; protein homotetramerization [GO:0051289]; regulation of urine volume [GO:0035809]	calcium channel activity [GO:0005262]	apical plasma membrane [GO:0016324]; calcium channel complex [GO:0034704]; plasma membrane [GO:0005886]	GO:0005262; GO:0005886; GO:0006816; GO:0016324; GO:0034704; GO:0035809; GO:0051289; GO:0055074; GO:0060402; GO:0070588; GO:0098703
GN006647	GN006647.1	Q9JIP0	25.0	616	905	723	2.37e-29	129	TRPV5_RAT	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transporter 2) (CaT2) (Epithelial calcium channel 1) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3)	Rattus norvegicus (Rat)	calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; protein homotetramerization [GO:0051289]; regulation of urine volume [GO:0035809]	calcium channel activity [GO:0005262]	apical plasma membrane [GO:0016324]; calcium channel complex [GO:0034704]; plasma membrane [GO:0005886]	GO:0005262; GO:0005886; GO:0006816; GO:0016324; GO:0034704; GO:0035809; GO:0051289; GO:0055074; GO:0060402; GO:0070588; GO:0098703
GN006648	GN006648.1	Q9XZC0	30.7	114	222	1413	8.44e-10	61.6	LCTA_LATTR	Alpha-latrocrustotoxin-Lt1a (Alpha-LCT-Lt1a) (Alpha-latrocrustotoxin) (Alpha-LCT) (Crusta1)	Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus)			extracellular region [GO:0005576]	GO:0005576
GN006654	GN006654.1	Q9UPV0	66.7	99	1335	1460	4.41e-35	150	CE164_HUMAN	Centrosomal protein of 164 kDa (Cep164)	Homo sapiens (Human)	cilium assembly [GO:0060271]		9+2 motile cilium [GO:0097729]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]	GO:0005576; GO:0005654; GO:0005813; GO:0005814; GO:0005829; GO:0060271; GO:0097539; GO:0097729
GN006657	GN006657.1	Q460N3	24.0	728	930	678	1.74e-33	141	PAR15_HUMAN	Protein mono-ADP-ribosyltransferase PARP15 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) (Poly [ADP-ribose] polymerase 15) (PARP-15)	Homo sapiens (Human)	negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein poly-ADP-ribosylation [GO:0070212]	NAD+ binding [GO:0070403]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000122; GO:0003714; GO:0003950; GO:0005634; GO:0005737; GO:0010629; GO:0070212; GO:0070403; GO:0140806; GO:0140807; GO:1990404
GN006660	GN006660.1	P07439	30.7	127	169	162	9.92e-15	70.9	LEC3_MEGRO	Lectin BRA-3	Megabalanus rosa (Acorn barnacle)				
GN006661	GN006661.1	Q5SPF7	34.6	436	452	465	7.45e-84	268	UN93A_DANRE	N-acetylglucosamine transporter UNC93A (Protein unc-93 homolog A) (Unc-93A)	Danio rerio (Zebrafish) (Brachydanio rerio)		N-acetylglucosamine transmembrane transporter activity [GO:0015572]	plasma membrane [GO:0005886]	GO:0005886; GO:0015572
GN006663	GN006663.1	P07439	29.9	127	354	162	1.19e-12	68.6	LEC3_MEGRO	Lectin BRA-3	Megabalanus rosa (Acorn barnacle)				
GN006664	GN006664.1	P07742	81.3	795	795	792	0.0	1318	RIR1_MOUSE	Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)	Mus musculus (Mouse)	2'-deoxyribonucleotide biosynthetic process [GO:0009265]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; dTMP biosynthetic process [GO:0006231]; mitochondrial DNA replication [GO:0006264]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein heterotetramerization [GO:0051290]; ribonucleoside diphosphate metabolic process [GO:0009185]	ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; purine nucleotide binding [GO:0017076]; ribonucleoside-diphosphate reductase activity [GO:0061731]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]	centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; ribonucleoside-diphosphate reductase complex [GO:0005971]	GO:0000731; GO:0004748; GO:0005524; GO:0005635; GO:0005739; GO:0005829; GO:0005971; GO:0006231; GO:0006264; GO:0006281; GO:0009185; GO:0009263; GO:0009265; GO:0010971; GO:0017076; GO:0034451; GO:0036064; GO:0042802; GO:0043025; GO:0051290; GO:0061731; GO:0070318; GO:0097718; GO:1900087
GN006665	GN006665.1	Q9HC07	65.0	243	294	324	5.24e-97	291	TM165_HUMAN	Putative divalent cation/proton antiporter TMEM165 (Transmembrane protein 165) (Transmembrane protein PT27) (Transmembrane protein TPARL)	Homo sapiens (Human)	calcium ion transport [GO:0006816]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; manganese ion transport [GO:0006828]	metal ion transmembrane transporter activity [GO:0046873]	cis-Golgi network membrane [GO:0033106]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]	GO:0000139; GO:0005765; GO:0005794; GO:0006816; GO:0006828; GO:0010008; GO:0032468; GO:0032472; GO:0032588; GO:0033106; GO:0046873
GN006669	GN006669.1	Q04799	54.0	450	464	533	2.32e-168	487	FMO5_RABIT	Flavin-containing monooxygenase 5 (FMO 5) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (FMO 1C1) (FMO form 3) (Hepatic flavin-containing monooxygenase 5) (NADPH oxidase) (EC 1.6.3.1)	Oryctolagus cuniculus (Rabbit)	regulation of cholesterol metabolic process [GO:0090181]; xenobiotic metabolic process [GO:0006805]	flavin adenine dinucleotide binding [GO:0050660]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADP binding [GO:0050661]	endoplasmic reticulum membrane [GO:0005789]	GO:0004497; GO:0004499; GO:0005789; GO:0006805; GO:0016174; GO:0050660; GO:0050661; GO:0090181
GN006671	GN006671.1	Q6W3E9	34.6	243	392	544	2.37e-26	114	P4HA3_RAT	Prolyl 4-hydroxylase subunit alpha-3 (4-PH alpha-3) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3)	Rattus norvegicus (Rat)		iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656]	endoplasmic reticulum lumen [GO:0005788]; procollagen-proline 4-dioxygenase complex [GO:0016222]	GO:0004656; GO:0005506; GO:0005788; GO:0016222; GO:0031418
GN006675	GN006675.1	Q9UPV9	40.3	685	937	953	1.77e-117	385	TRAK1_HUMAN	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton)	Homo sapiens (Human)	axonal transport of mitochondrion [GO:0019896]; dendrite morphogenesis [GO:0048813]; endosome to lysosome transport [GO:0008333]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; positive regulation of axonogenesis [GO:0050772]; protein O-linked glycosylation [GO:0006493]; protein targeting [GO:0006605]; regulation of transcription by RNA polymerase II [GO:0006357]; vesicle transport along microtubule [GO:0047496]	GABA receptor binding [GO:0050811]; myosin binding [GO:0017022]; TPR domain binding [GO:0030911]	axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; endosome [GO:0005768]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0005634; GO:0005737; GO:0005739; GO:0005768; GO:0005769; GO:0005829; GO:0005938; GO:0006357; GO:0006493; GO:0006605; GO:0008333; GO:0017022; GO:0019896; GO:0022008; GO:0030425; GO:0030911; GO:0031410; GO:0031966; GO:0044295; GO:0047496; GO:0048311; GO:0048471; GO:0048813; GO:0050772; GO:0050811; GO:1904115
GN006676	GN006676.1	Q6ZS30	43.5	191	191	2694	7.58e-45	161	NBEL1_HUMAN	Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein)	Homo sapiens (Human)			cytosol [GO:0005829]; membrane [GO:0016020]	GO:0005829; GO:0016020
GN006680	GN006680.1	P11799	38.8	85	90	1906	1.04e-14	70.9	MYLK_CHICK	Myosin light chain kinase, smooth muscle (MLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]	Gallus gallus (Chicken)	cardiac muscle cell development [GO:0055013]; heart morphogenesis [GO:0003007]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of striated muscle contraction [GO:0045989]; tonic smooth muscle contraction [GO:0014820]	ATP binding [GO:0005524]; myosin light chain kinase activity [GO:0004687]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; stress fiber [GO:0001725]	GO:0001725; GO:0003007; GO:0004687; GO:0005524; GO:0005737; GO:0005829; GO:0014820; GO:0030027; GO:0032154; GO:0045989; GO:0055013; GO:0060298
GN006681	GN006681.1	A2T7H5	50.6	168	339	265	3.44e-36	134	CDX1_PONPY	Homeobox protein CDX-1 (Caudal-type homeobox protein 1)	Pongo pygmaeus (Bornean orangutan)	animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification [GO:0009948]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of somitogenesis [GO:0014807]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; methyl-CpG binding [GO:0008327]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]	GO:0000976; GO:0000977; GO:0000981; GO:0003700; GO:0005634; GO:0008327; GO:0009887; GO:0009948; GO:0014807; GO:0030154; GO:0045944
GN006682	GN006682.1	Q9ULJ7	41.0	227	216	1429	2.27e-48	172	ANR50_HUMAN	Ankyrin repeat domain-containing protein 50	Homo sapiens (Human)	endocytic recycling [GO:0032456]		endosome [GO:0005768]	GO:0005768; GO:0032456
GN006683	GN006683.1	Q6PFY8	21.7	378	643	580	5.53e-22	103	TRI45_MOUSE	E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99) (Tripartite motif-containing protein 45)	Mus musculus (Mouse)	bone development [GO:0060348]; inflammatory response [GO:0006954]; negative regulation of inflammatory response [GO:0050728]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006954; GO:0008270; GO:0043161; GO:0045171; GO:0050728; GO:0060348; GO:0061630; GO:0070936
GN006684	GN006684.1	O00625	53.5	273	292	290	1.70e-104	309	PIR_HUMAN	Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)	Homo sapiens (Human)	digestion [GO:0007586]; monocyte differentiation [GO:0030224]; transcription by RNA polymerase II [GO:0006366]	metal ion binding [GO:0046872]; quercetin 2,3-dioxygenase activity [GO:0008127]; transcription coregulator activity [GO:0003712]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003712; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006366; GO:0007586; GO:0008127; GO:0016604; GO:0030224; GO:0046872
GN006685	GN006685.1	O00625	62.9	286	294	290	1.26e-133	383	PIR_HUMAN	Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)	Homo sapiens (Human)	digestion [GO:0007586]; monocyte differentiation [GO:0030224]; transcription by RNA polymerase II [GO:0006366]	metal ion binding [GO:0046872]; quercetin 2,3-dioxygenase activity [GO:0008127]; transcription coregulator activity [GO:0003712]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003712; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006366; GO:0007586; GO:0008127; GO:0016604; GO:0030224; GO:0046872
GN006690	GN006690.1	Q05707	29.9	184	465	1796	6.73e-14	78.2	COEA1_HUMAN	Collagen alpha-1(XIV) chain (Undulin)	Homo sapiens (Human)	cell-cell adhesion [GO:0098609]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]	collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]	collagen trimer [GO:0005581]; collagen type XIV trimer [GO:0005596]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; interstitial matrix [GO:0005614]	GO:0003723; GO:0005201; GO:0005518; GO:0005576; GO:0005581; GO:0005596; GO:0005614; GO:0005788; GO:0030020; GO:0030198; GO:0030199; GO:0030674; GO:0031012; GO:0098609
GN006693	GN006693.1	O01393	31.4	382	441	386	2.01e-53	186	UNC9_CAEEL	Innexin unc-9 (Uncoordinated protein 9)	Caenorhabditis elegans	monoatomic ion transmembrane transport [GO:0034220]; positive regulation of locomotion [GO:0040017]	actin filament binding [GO:0051015]; gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	cell-cell junction [GO:0005911]; gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0034220; GO:0040017; GO:0051015; GO:0055077
GN006694	GN006694.1	O01393	33.7	371	840	386	7.81e-64	222	UNC9_CAEEL	Innexin unc-9 (Uncoordinated protein 9)	Caenorhabditis elegans	monoatomic ion transmembrane transport [GO:0034220]; positive regulation of locomotion [GO:0040017]	actin filament binding [GO:0051015]; gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	cell-cell junction [GO:0005911]; gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0034220; GO:0040017; GO:0051015; GO:0055077
GN006695	GN006695.1	Q9CWV0	49.1	106	326	228	2.17e-27	110	MASU1_MOUSE	Mitochondrial assembly of ribosomal large subunit protein 1	Mus musculus (Mouse)	mitochondrial large ribosomal subunit assembly [GO:1902775]; negative regulation of mitochondrial translation [GO:0070130]; negative regulation of ribosome biogenesis [GO:0090071]; negative regulation of translation [GO:0017148]; ribosomal large subunit biogenesis [GO:0042273]	mitochondrial large ribosomal subunit binding [GO:0140978]; ribosomal large subunit binding [GO:0043023]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0005829; GO:0017148; GO:0042273; GO:0043023; GO:0070130; GO:0090071; GO:0140978; GO:1902775
GN006696	GN006696.1	Q9HCG8	71.2	541	1554	908	6.22e-256	763	CWC22_HUMAN	Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb)	Homo sapiens (Human)	mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-spliceosomal complex [GO:0071020]; spliceosomal complex [GO:0005681]; U12-type catalytic step 2 spliceosome [GO:0071018]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]	GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0016607; GO:0048024; GO:0071005; GO:0071006; GO:0071007; GO:0071013; GO:0071018; GO:0071020
GN006699	GN006699.1	Q8CFH6	52.0	661	985	931	1.12e-176	541	SIK2_MOUSE	Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)	Mus musculus (Mouse)	ERAD pathway [GO:0036503]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; lipid biosynthetic process [GO:0008610]; negative regulation of transcription from RNA polymerase II promoter by glucose [GO:0061987]; positive regulation of ERAD pathway [GO:1904294]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of insulin receptor signaling pathway [GO:0046626]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005789; GO:0006468; GO:0008286; GO:0008610; GO:0035556; GO:0036503; GO:0046626; GO:0046777; GO:0061987; GO:0106310; GO:1904294
GN006700	GN006700.1	Q9Z0Z3	24.3	354	493	424	7.15e-14	77.0	SKP2_MOUSE	S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/WD-40 protein 1) (FWD1)	Mus musculus (Mouse)	defense response to virus [GO:0051607]; DNA double-strand break processing [GO:0000729]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; innate immune response [GO:0045087]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of smooth muscle cell proliferation [GO:0048661]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein localization to site of double-strand break [GO:1990166]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; ubiquitin-dependent protein catabolic process [GO:0006511]	identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0000082; GO:0000086; GO:0000209; GO:0000729; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0019005; GO:0033148; GO:0042802; GO:0042981; GO:0043161; GO:0045087; GO:0048661; GO:0051607; GO:0051726; GO:0070534; GO:0070936; GO:1902916; GO:1905168; GO:1990166; GO:1990756
GN006701	GN006701.1	P86221	98.7	78	90	290	2.87e-51	165	TBB4B_MESAU	Tubulin beta-4B chain (Tubulin beta-2C chain)	Mesocricetus auratus (Golden hamster)	microtubule-based process [GO:0007017]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]	microtubule [GO:0005874]	GO:0003924; GO:0005200; GO:0005525; GO:0005874; GO:0007017
GN006702	GN006702.1	Q8NB14	33.4	784	855	1042	8.06e-101	340	UBP38_HUMAN	Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.4.19.12) (Deubiquitinating enzyme 38) (HP43.8KD) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38)	Homo sapiens (Human)	negative regulation of innate immune response [GO:0045824]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; protein K33-linked deubiquitination [GO:1990168]; ubiquitin-dependent protein catabolic process [GO:0006511]	cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004843; GO:0005634; GO:0005737; GO:0006511; GO:0032435; GO:0045824; GO:1990168
GN006703	GN006703.1	Q5E9N5	59.8	557	623	677	1.32e-232	662	CLPB_BOVIN	Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form]	Bos taurus (Bovine)	cellular response to heat [GO:0034605]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]	GO:0005524; GO:0005739; GO:0005758; GO:0016887; GO:0034605
GN006704	GN006704.1	Q9P241	40.9	1352	1370	1426	1.67e-313	924	AT10D_HUMAN	Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D)	Homo sapiens (Human)	monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; glycosylceramide flippase activity [GO:0140351]; magnesium ion binding [GO:0000287]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; phospholipid-translocating ATPase complex [GO:1990531]; plasma membrane [GO:0005886]	GO:0000287; GO:0005524; GO:0005783; GO:0005789; GO:0005886; GO:0006812; GO:0016020; GO:0016887; GO:0034220; GO:0045332; GO:0140326; GO:0140351; GO:1990531
GN006707	GN006707.1	Q0VAA2	52.4	63	532	488	1.76e-11	70.1	LR74A_HUMAN	Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74)	Homo sapiens (Human)				
GN006708	GN006708.1	E7FCN8	28.3	799	831	915	3.48e-71	255	INTU_DANRE	Protein inturned (Inturned planar cell polarity effector homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; establishment of planar polarity [GO:0001736]; limb development [GO:0060173]; nervous system development [GO:0007399]; regulation of smoothened signaling pathway [GO:0008589]; vesicle-mediated transport [GO:0016192]		cell surface [GO:0009986]; cilium [GO:0005929]; cytoplasm [GO:0005737]	GO:0001736; GO:0005737; GO:0005929; GO:0007399; GO:0008589; GO:0009986; GO:0016192; GO:0060173; GO:0060271
GN006709	GN006709.1	H9J9M0	30.2	96	124	539	1.22e-11	63.5	CDA1_BOMMO	Chitin deacetylase 1 (BmCDA1) (EC 3.5.1.41)	Bombyx mori (Silk moth)	polysaccharide catabolic process [GO:0000272]	chitin binding [GO:0008061]; chitin deacetylase activity [GO:0004099]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0000272; GO:0004099; GO:0005576; GO:0008061; GO:0008270
GN006710	GN006710.1	H9JW43	31.7	167	183	381	1.61e-16	79.3	CDA8_BOMMO	Chitin deacetylase 8 (BmCDA8) (EC 3.5.1.41) (Chitin deacetylase 17)	Bombyx mori (Silk moth)	polysaccharide catabolic process [GO:0000272]	chitin deacetylase activity [GO:0004099]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0000272; GO:0004099; GO:0005576; GO:0008270
GN006712	GN006712.1	H9J9M0	28.2	326	325	539	7.76e-36	139	CDA1_BOMMO	Chitin deacetylase 1 (BmCDA1) (EC 3.5.1.41)	Bombyx mori (Silk moth)	polysaccharide catabolic process [GO:0000272]	chitin binding [GO:0008061]; chitin deacetylase activity [GO:0004099]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0000272; GO:0004099; GO:0005576; GO:0008061; GO:0008270
GN006714	GN006714.1	O94826	44.2	577	589	608	5.12e-147	440	TOM70_HUMAN	Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70)	Homo sapiens (Human)	activation of innate immune response [GO:0002218]; cellular response to virus [GO:0098586]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of protein localization to mitochondrion [GO:1903749]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial inner membrane [GO:0045039]; protein insertion into mitochondrial outer membrane [GO:0045040]; protein localization to mitochondrion [GO:0070585]; regulation of apoptotic process [GO:0042981]; response to thyroxine [GO:0097068]	mitochondrion targeting sequence binding [GO:0030943]; protein-macromolecule adaptor activity [GO:0030674]; transmembrane protein transporter activity [GO:0008320]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; TOM complex [GO:0140596]	GO:0002218; GO:0002230; GO:0005739; GO:0005741; GO:0005742; GO:0008320; GO:0016020; GO:0030150; GO:0030674; GO:0030943; GO:0031966; GO:0032728; GO:0042981; GO:0045039; GO:0045040; GO:0061052; GO:0070062; GO:0070585; GO:0097068; GO:0098586; GO:0140596; GO:1903749
GN006715	GN006715.1	Q5ZIR1	53.0	389	381	366	1.19e-128	377	SHLB1_CHICK	Endophilin-B1 (SH3 domain-containing GRB2-like protein B1)	Gallus gallus (Chicken)	endocytosis [GO:0006897]; membrane organization [GO:0061024]	protein-macromolecule adaptor activity [GO:0030674]	cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]	GO:0000139; GO:0005737; GO:0005741; GO:0006897; GO:0016020; GO:0030674; GO:0061024
GN006717	GN006717.1	P32297	29.6	284	279	505	1.59e-38	144	ACHA3_HUMAN	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (Human)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; excitatory postsynaptic potential [GO:0060079]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of acetylcholine secretion, neurotransmission [GO:0014056]; regulation of appetite [GO:0032098]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane potential [GO:0042391]; regulation of smooth muscle contraction [GO:0006940]; response to acetylcholine [GO:1905144]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005783; GO:0005794; GO:0005886; GO:0005892; GO:0006811; GO:0006816; GO:0006940; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0007626; GO:0014056; GO:0015276; GO:0015464; GO:0016020; GO:0022848; GO:0030425; GO:0030594; GO:0032098; GO:0034220; GO:0035094; GO:0035095; GO:0042166; GO:0042391; GO:0042734; GO:0043005; GO:0043025; GO:0044853; GO:0045202; GO:0045211; GO:0048814; GO:0051899; GO:0060079; GO:0060084; GO:0095500; GO:0097060; GO:0099171; GO:1905144
GN006718	GN006718.1	P09628	32.3	282	336	521	2.56e-39	148	ACHD_XENLA	Acetylcholine receptor subunit delta	Xenopus laevis (African clawed frog)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; skeletal muscle contraction [GO:0003009]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0003009; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0015464; GO:0022848; GO:0034220; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500
GN006719	GN006719.1	P43143	29.1	313	441	493	1.18e-44	165	ACHA6_RAT	Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Rat)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0014059; GO:0022848; GO:0030594; GO:0032991; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN006721	GN006721.1	Q5BQN8	49.1	554	1362	1338	3.91e-57	221	CPAP_PANTR	Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein)	Pan troglodytes (Chimpanzee)	centriole elongation [GO:0061511]; centriole replication [GO:0007099]; cilium assembly [GO:0060271]; positive regulation of centriole elongation [GO:1903724]; positive regulation of establishment of protein localization [GO:1904951]; regulation of centriole replication [GO:0046599]	tubulin binding [GO:0015631]	centriole [GO:0005814]; centrosome [GO:0005813]	GO:0005813; GO:0005814; GO:0007099; GO:0015631; GO:0046599; GO:0060271; GO:0061511; GO:1903724; GO:1904951
GN006722	GN006722.1	Q5ZJD3	47.5	160	208	653	3.88e-32	125	LSG1_CHICK	Large subunit GTPase 1 homolog (EC 3.6.5.-)	Gallus gallus (Chicken)	nuclear export [GO:0051168]; ribosomal subunit export from nucleus [GO:0000054]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]	GO:0000054; GO:0003924; GO:0005525; GO:0005737; GO:0005783; GO:0015030; GO:0051168
GN006723	GN006723.1	Q16513	56.2	989	1002	984	0.0	981	PKN2_HUMAN	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)	Homo sapiens (Human)	apical junction assembly [GO:0043297]; epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of cell motility [GO:2000145]; signal transduction [GO:0007165]; vascular endothelial cell response to laminar fluid shear stress [GO:0097700]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; histone deacetylase binding [GO:0042826]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; small GTPase binding [GO:0031267]	anchoring junction [GO:0070161]; apical junction complex [GO:0043296]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	GO:0003723; GO:0004672; GO:0004674; GO:0004697; GO:0004713; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006468; GO:0007165; GO:0010631; GO:0016301; GO:0030027; GO:0030496; GO:0031267; GO:0032154; GO:0032467; GO:0032991; GO:0035556; GO:0042826; GO:0043296; GO:0043297; GO:0045070; GO:0045111; GO:0045296; GO:0045931; GO:0048471; GO:0070063; GO:0070161; GO:0097700; GO:0106310; GO:2000145
GN006724	GN006724.1	Q6P7N4	40.8	348	388	335	1.24e-79	251	HMCES_XENTR	Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	DNA damage response [GO:0006974]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; interstrand cross-link repair [GO:0036297]; positive regulation of isotype switching [GO:0045830]; protein-DNA covalent cross-linking repair [GO:0106300]; somatic hypermutation of immunoglobulin genes [GO:0016446]	DNA-(abasic site) binding [GO:0140431]; protein-DNA covalent cross-linking activity [GO:0160129]; single-stranded DNA binding [GO:0003697]	chromosome [GO:0005694]; replication fork [GO:0005657]	GO:0003697; GO:0005657; GO:0005694; GO:0006974; GO:0016446; GO:0036297; GO:0045830; GO:0097681; GO:0106300; GO:0140431; GO:0160129
GN006727	GN006727.1	Q99M71	35.8	179	209	224	7.51e-33	120	EPDR1_MOUSE	Mammalian ependymin-related protein 1 (MERP-1)	Mus musculus (Mouse)	cell-matrix adhesion [GO:0007160]; myofibroblast contraction [GO:1990764]	calcium ion binding [GO:0005509]; ganglioside GM1 binding [GO:1905573]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]	extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	GO:0005509; GO:0005543; GO:0005576; GO:0005764; GO:0007160; GO:0042802; GO:0043202; GO:1905573; GO:1990764
GN006737	GN006737.1	O88307	25.3	450	623	2215	6.18e-19	95.5	SORL_MOUSE	Sortilin-related receptor (Gp250) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA)	Mus musculus (Mouse)	adaptive thermogenesis [GO:1990845]; amyloid-beta formation [GO:0034205]; cell migration [GO:0016477]; diet induced thermogenesis [GO:0002024]; endosome to plasma membrane protein transport [GO:0099638]; insulin receptor recycling [GO:0038020]; lysosomal protein catabolic process [GO:1905146]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of neurofibrillary tangle assembly [GO:1902997]; negative regulation of neurogenesis [GO:0050768]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of triglyceride catabolic process [GO:0010897]; neuropeptide signaling pathway [GO:0007218]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of glial cell-derived neurotrophic factor production [GO:1900168]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to early endosome [GO:1902966]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to Golgi apparatus [GO:0034067]; protein retention in Golgi apparatus [GO:0045053]; protein targeting [GO:0006605]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; regulation of smooth muscle cell migration [GO:0014910]; retrograde transport, endosome to Golgi [GO:0042147]	amyloid-beta binding [GO:0001540]; aspartic-type endopeptidase inhibitor activity [GO:0019828]; cargo receptor activity [GO:0038024]; low-density lipoprotein particle binding [GO:0030169]; neuropeptide binding [GO:0042923]; protein transporter activity [GO:0140318]; small GTPase binding [GO:0031267]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; membrane [GO:0016020]; multivesicular body [GO:0005771]; multivesicular body membrane [GO:0032585]; neuronal cell body [GO:0043025]; nuclear envelope lumen [GO:0005641]; perinuclear region of cytoplasm [GO:0048471]; perinucleolar compartment [GO:0097356]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; transport vesicle membrane [GO:0030658]	GO:0000139; GO:0001540; GO:0001960; GO:0002024; GO:0004888; GO:0005576; GO:0005641; GO:0005764; GO:0005768; GO:0005769; GO:0005771; GO:0005783; GO:0005789; GO:0005794; GO:0005802; GO:0005829; GO:0005886; GO:0006605; GO:0006622; GO:0006892; GO:0006898; GO:0007218; GO:0009986; GO:0010008; GO:0010897; GO:0014910; GO:0016020; GO:0016477; GO:0019828; GO:0030169; GO:0030514; GO:0030658; GO:0031267; GO:0031333; GO:0031901; GO:0031985; GO:0032585; GO:0034067; GO:0034205; GO:0038020; GO:0038024; GO:0042147; GO:0042923; GO:0043025; GO:0045053; GO:0045732; GO:0046628; GO:0048471; GO:0050768; GO:0055037; GO:0055038; GO:0070863; GO:0097356; GO:0099638; GO:0140318; GO:1900168; GO:1902430; GO:1902953; GO:1902966; GO:1902992; GO:1902997; GO:1904179; GO:1905146; GO:1990845; GO:2001137
GN006738	GN006738.1	Q01414	67.4	92	415	173	2.37e-39	142	ERG_LYTVA	Transcriptional regulator ERG homolog	Lytechinus variegatus (Green sea urchin) (Echinus variegatus)	cell differentiation [GO:0030154]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0030154; GO:0043565
GN006739	GN006739.1	Q18579	71.1	97	265	208	5.23e-42	145	ETS5_CAEEL	ETS domain-containing transcription factor ets-5	Caenorhabditis elegans	cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0006357; GO:0030154; GO:0043565
GN006740	GN006740.1	Q9BSE2	29.0	169	187	394	1.86e-11	65.1	TMM79_HUMAN	Transmembrane protein 79 (Mattrin)	Homo sapiens (Human)	epithelial cell maturation [GO:0002070]; establishment of skin barrier [GO:0061436]; positive regulation of epidermis development [GO:0045684]; regulated exocytosis [GO:0045055]	identical protein binding [GO:0042802]	lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]	GO:0002070; GO:0005765; GO:0032588; GO:0042802; GO:0045055; GO:0045684; GO:0061436
GN006742	GN006742.1	Q9BSE2	27.1	140	187	394	5.41e-10	60.8	TMM79_HUMAN	Transmembrane protein 79 (Mattrin)	Homo sapiens (Human)	epithelial cell maturation [GO:0002070]; establishment of skin barrier [GO:0061436]; positive regulation of epidermis development [GO:0045684]; regulated exocytosis [GO:0045055]	identical protein binding [GO:0042802]	lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]	GO:0002070; GO:0005765; GO:0032588; GO:0042802; GO:0045055; GO:0045684; GO:0061436
GN006743	GN006743.1	Q9D709	27.2	162	188	391	4.66e-09	58.2	TMM79_MOUSE	Transmembrane protein 79 (Mattrin)	Mus musculus (Mouse)	cornification [GO:0070268]; cuticle development [GO:0042335]; epithelial cell maturation [GO:0002070]; establishment of skin barrier [GO:0061436]; hair follicle morphogenesis [GO:0031069]; positive regulation of epidermis development [GO:0045684]; regulated exocytosis [GO:0045055]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]	GO:0002070; GO:0005737; GO:0005765; GO:0031069; GO:0032588; GO:0042335; GO:0042802; GO:0045055; GO:0045684; GO:0061436; GO:0070268
GN006744	GN006744.1	Q9BSE2	26.5	136	186	394	1.14e-12	68.6	TMM79_HUMAN	Transmembrane protein 79 (Mattrin)	Homo sapiens (Human)	epithelial cell maturation [GO:0002070]; establishment of skin barrier [GO:0061436]; positive regulation of epidermis development [GO:0045684]; regulated exocytosis [GO:0045055]	identical protein binding [GO:0042802]	lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]	GO:0002070; GO:0005765; GO:0032588; GO:0042802; GO:0045055; GO:0045684; GO:0061436
GN006745	GN006745.1	Q9BSE2	23.9	163	185	394	4.38e-09	58.2	TMM79_HUMAN	Transmembrane protein 79 (Mattrin)	Homo sapiens (Human)	epithelial cell maturation [GO:0002070]; establishment of skin barrier [GO:0061436]; positive regulation of epidermis development [GO:0045684]; regulated exocytosis [GO:0045055]	identical protein binding [GO:0042802]	lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]	GO:0002070; GO:0005765; GO:0032588; GO:0042802; GO:0045055; GO:0045684; GO:0061436
GN006746	GN006746.1	Q5U239	41.2	194	309	547	6.65e-41	152	TM145_XENLA	Transmembrane protein 145	Xenopus laevis (African clawed frog)	G protein-coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236]		membrane [GO:0016020]	GO:0007186; GO:0016020; GO:0019236
GN006747	GN006747.1	P51871	42.2	187	180	537	4.54e-47	164	CP4F6_RAT	Cytochrome P450 4F6 (EC 1.14.14.1) (CYPIVF6)	Rattus norvegicus (Rat)	leukotriene metabolic process [GO:0006691]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005789; GO:0006691; GO:0016712; GO:0020037
GN006749	GN006749.1	Q9Z2F6	33.6	143	312	448	2.11e-11	67.8	BCL3_MOUSE	B-cell lymphoma 3 protein homolog (BCL-3)	Mus musculus (Mouse)	antimicrobial humoral response [GO:0019730]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of type II interferon production [GO:0032729]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to UV-C [GO:0010225]; response to virus [GO:0009615]; spleen development [GO:0048536]; T-helper 1 type immune response [GO:0042088]; T-helper 2 cell differentiation [GO:0045064]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	Bcl3-Bcl10 complex [GO:0032996]; Bcl3/NF-kappaB2 complex [GO:0033257]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	GO:0002268; GO:0002315; GO:0002455; GO:0002467; GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006606; GO:0006974; GO:0007249; GO:0009615; GO:0010225; GO:0019730; GO:0030198; GO:0030330; GO:0030496; GO:0030674; GO:0032717; GO:0032720; GO:0032729; GO:0032733; GO:0032991; GO:0032996; GO:0033257; GO:0036064; GO:0042088; GO:0042742; GO:0042771; GO:0042826; GO:0042832; GO:0042981; GO:0043066; GO:0045064; GO:0045727; GO:0045892; GO:0045893; GO:0045944; GO:0046426; GO:0048471; GO:0048536; GO:0140297; GO:1901222; GO:1901223
GN006751	GN006751.1	E9QI36	67.7	496	522	513	1.11e-235	660	HARS1_DANRE	Histidine--tRNA ligase (EC 6.1.1.21)	Danio rerio (Zebrafish) (Brachydanio rerio)	histidyl-tRNA aminoacylation [GO:0006427]; mitochondrial translation [GO:0032543]; regulation of vasculature development [GO:1901342]; sprouting angiogenesis [GO:0002040]	ATP binding [GO:0005524]; histidine-tRNA ligase activity [GO:0004821]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0002040; GO:0003723; GO:0004821; GO:0005524; GO:0005737; GO:0005739; GO:0005829; GO:0006427; GO:0032543; GO:1901342
GN006752	GN006752.1	Q8NEY3	46.7	184	290	305	1.97e-48	166	SPAT4_HUMAN	Spermatogenesis-associated protein 4 (Testis and spermatogenesis cell-related protein 2) (Testis spermatocyte apoptosis-related gene 2 protein)	Homo sapiens (Human)	regulation of cytoskeleton organization [GO:0051493]	microtubule binding [GO:0008017]	axoneme [GO:0005930]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005930; GO:0008017; GO:0051493
GN006756	GN006756.1	Q9P2G9	47.8	345	636	620	3.98e-111	350	KLHL8_HUMAN	Kelch-like protein 8	Homo sapiens (Human)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0006511; GO:0016567; GO:0031463; GO:0043161; GO:1990756
GN006757	GN006757.1	Q8BTV1	66.3	240	307	347	4.43e-122	356	TUSC3_MOUSE	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3 (Oligosaccharyl transferase subunit TUSC3) (Magnesium uptake/transporter TUSC3) (Protein N33) (Tumor suppressor candidate 3)	Mus musculus (Mouse)	cognition [GO:0050890]; magnesium ion transmembrane transport [GO:1903830]; magnesium ion transport [GO:0015693]; protein N-linked glycosylation [GO:0006487]	magnesium ion transmembrane transporter activity [GO:0015095]; oligosaccharyltransferase complex binding [GO:0062062]	endoplasmic reticulum membrane [GO:0005789]; mitochondrion [GO:0005739]; oligosaccharyltransferase complex [GO:0008250]	GO:0005739; GO:0005789; GO:0006487; GO:0008250; GO:0015095; GO:0015693; GO:0050890; GO:0062062; GO:1903830
GN006758	GN006758.1	Q13887	50.4	117	473	457	5.35e-23	104	KLF5_HUMAN	Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)	Homo sapiens (Human)	cellular response to endothelin [GO:1990859]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; MRF binding [GO:0043426]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0005654; GO:0005667; GO:0006357; GO:0008284; GO:0043426; GO:0045944; GO:1990837; GO:1990859
GN006762	GN006762.1	P40237	26.7	277	277	266	4.52e-13	70.9	CD82_MOUSE	CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1 homolog) (CD antigen CD82)	Mus musculus (Mouse)			phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	GO:0005886; GO:0045335
GN006763	GN006763.1	Q61451	34.5	119	238	219	4.45e-12	66.6	CD53_MOUSE	Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (CD antigen CD53)	Mus musculus (Mouse)	positive regulation of myoblast fusion [GO:1901741]; receptor clustering [GO:0043113]; T cell receptor signaling pathway [GO:0050852]	identical protein binding [GO:0042802]; protein-membrane adaptor activity [GO:0043495]	anchoring junction [GO:0070161]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; immunological synapse [GO:0001772]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0001772; GO:0005886; GO:0005911; GO:0009986; GO:0016020; GO:0042802; GO:0043113; GO:0043495; GO:0045202; GO:0050852; GO:0070161; GO:1901741
GN006764	GN006764.1	Q0IUU4	29.1	151	222	183	7.08e-14	70.5	CML2_ORYSJ	Putative calmodulin-like protein 2	Oryza sativa subsp. japonica (Rice)		calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]	membrane [GO:0016020]	GO:0005509; GO:0016020; GO:0030234
GN006766	GN006766.1	Q8WU90	50.2	291	292	426	4.04e-76	241	ZC3HF_HUMAN	Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4)	Homo sapiens (Human)	cytoplasmic translation [GO:0002181]; positive regulation of GTPase activity [GO:0043547]	cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0002181; GO:0003723; GO:0005634; GO:0005737; GO:0005829; GO:0043547; GO:0045296; GO:0046872
GN006769	GN006769.1	Q6GMK8	62.0	382	382	422	4.31e-150	433	GMPAA_DANRE	Mannose-1-phosphate guanylyltransferase regulatory subunit alpha-A (GDP-mannose pyrophosphorylase A-A) (GTP-mannose-1-phosphate guanylyltransferase subunit alpha-A)	Danio rerio (Zebrafish) (Brachydanio rerio)	GDP-mannose biosynthetic process [GO:0009298]	transferase activity [GO:0016740]		GO:0009298; GO:0016740
GN006770	GN006770.1	Q9D9G2	41.7	132	196	242	1.15e-23	97.1	PEBP4_MOUSE	Phosphatidylethanolamine-binding protein 4 (PEBP-4)	Mus musculus (Mouse)			extracellular region [GO:0005576]	GO:0005576
GN006771	GN006771.1	Q05084	41.9	590	589	483	1.06e-121	371	ICA69_HUMAN	Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69)	Homo sapiens (Human)	membrane bending [GO:0097753]; regulation of secretion [GO:0051046]	membrane curvature sensor activity [GO:0140090]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]	GO:0000139; GO:0005737; GO:0005829; GO:0019904; GO:0030667; GO:0030672; GO:0051046; GO:0097753; GO:0140090
GN006772	GN006772.1	P34473	34.2	117	288	201	6.73e-12	66.6	YMH6_CAEEL	Uncharacterized protein F58A4.6	Caenorhabditis elegans				
GN006773	GN006773.1	B0S8I0	39.4	188	205	286	1.03e-32	122	GTPB8_DANRE	GTP-binding protein 8	Danio rerio (Zebrafish) (Brachydanio rerio)		GTP binding [GO:0005525]	mitochondrion [GO:0005739]	GO:0005525; GO:0005739
GN006774	GN006774.1	Q54TA1	41.2	260	1084	749	1.47e-45	180	DRKC_DICDI	Probable serine/threonine-protein kinase drkC (EC 2.7.11.1) (Receptor-like kinase 3) (Receptor-like kinase C) (Vesicle-associated receptor tyrosine kinase-like protein 3)	Dictyostelium discoideum (Social amoeba)	phagocytosis [GO:0006909]; phagolysosome assembly [GO:0001845]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	phagocytic vesicle membrane [GO:0030670]; phagolysosome [GO:0032010]	GO:0001845; GO:0004674; GO:0004713; GO:0005524; GO:0006909; GO:0030670; GO:0032010; GO:0106310
GN006775	GN006775.1	Q5R614	62.7	1178	1175	1176	0.0	1546	SYLC_PONAB	Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	leucyl-tRNA aminoacylation [GO:0006429]	aminoacyl-tRNA deacylase activity [GO:0002161]; ATP binding [GO:0005524]; leucine-tRNA ligase activity [GO:0004823]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]	GO:0002161; GO:0004823; GO:0005524; GO:0005737; GO:0006429; GO:0017101
GN006776	GN006776.1	Q8WVJ2	57.0	151	154	157	4.83e-62	191	NUDC2_HUMAN	NudC domain-containing protein 2	Homo sapiens (Human)			centrosome [GO:0005813]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]	GO:0000922; GO:0005813; GO:0015630; GO:0072686
GN006777	GN006777.1	Q3SZP8	44.6	446	438	443	2.73e-122	365	TAD2A_BOVIN	Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein)	Bos taurus (Bovine)	chromatin remodeling [GO:0006338]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]	ATAC complex [GO:0140672]; chromosome [GO:0005694]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; SAGA-type complex [GO:0070461]	GO:0003682; GO:0003713; GO:0005634; GO:0005694; GO:0006338; GO:0006357; GO:0008270; GO:0045995; GO:0051302; GO:0051726; GO:0070461; GO:0072686; GO:0140672
GN006779	GN006779.1	O62770	37.1	197	563	153	1.31e-26	108	SP17_NOTEU	Sperm surface protein Sp17 (Sperm autoantigenic protein 17)	Notamacropus eugenii (Tammar wallaby) (Macropus eugenii)	binding of sperm to zona pellucida [GO:0007339]	calmodulin binding [GO:0005516]	cytoplasm [GO:0005737]; membrane [GO:0016020]; sperm fibrous sheath [GO:0035686]; sperm principal piece [GO:0097228]	GO:0005516; GO:0005737; GO:0007339; GO:0016020; GO:0035686; GO:0097228
GN006780	GN006780.1	P50615	45.0	131	365	252	1.71e-35	133	BTG3_MOUSE	Protein BTG3 (Abundant in neuroepithelium area protein) (BTG family member 3) (Protein Tob5)	Mus musculus (Mouse)	negative regulation of mitotic cell cycle [GO:0045930]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0045930
GN006781	GN006781.1	F1N5V1	57.7	71	368	981	6.20e-20	95.1	UBP37_BOVIN	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37)	Bos taurus (Bovine)	G1/S transition of mitotic cell cycle [GO:0000082]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; regulation of DNA replication [GO:0006275]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; protein kinase binding [GO:0019901]	chromosome [GO:0005694]; nucleus [GO:0005634]	GO:0000082; GO:0004197; GO:0004843; GO:0005634; GO:0005694; GO:0006275; GO:0016579; GO:0019901; GO:0035871; GO:0071108
GN006782	GN006782.1	Q8BGU5	60.4	366	361	341	1.73e-129	377	CCNY_MOUSE	Cyclin-Y (Cyclin fold protein 1)	Mus musculus (Mouse)	G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of autophagy [GO:0010508]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; regulation of canonical Wnt signaling pathway [GO:0060828]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]; protein kinase binding [GO:0019901]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasmic cyclin-dependent protein kinase holoenzyme complex [GO:0000308]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000086; GO:0000307; GO:0000308; GO:0005634; GO:0005654; GO:0005730; GO:0005886; GO:0010508; GO:0016538; GO:0019901; GO:0045737; GO:0060828; GO:0061575
GN006783	GN006783.1	Q05048	55.6	403	412	431	5.05e-149	432	CSTF1_HUMAN	Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50)	Homo sapiens (Human)	mRNA 3'-end processing [GO:0031124]; regulation of mRNA 3'-end processing [GO:0031440]	RNA binding [GO:0003723]	mRNA cleavage stimulating factor complex [GO:0005848]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005654; GO:0005848; GO:0031124; GO:0031440
GN006784	GN006784.1	Q09221	57.4	237	322	7705	3.33e-82	275	CPNA2_CAEEL	Copine family protein 2	Caenorhabditis elegans				
GN006788	GN006788.1	Q96NR8	54.5	288	293	316	9.68e-103	305	RDH12_HUMAN	Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2)	Homo sapiens (Human)	cellular detoxification of aldehyde [GO:0110095]; photoreceptor cell maintenance [GO:0045494]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]	11-cis-retinol dehydrogenase (NADP+) activity [GO:0102354]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]	endoplasmic reticulum membrane [GO:0005789]; photoreceptor inner segment [GO:0001917]; photoreceptor inner segment membrane [GO:0060342]	GO:0001523; GO:0001917; GO:0004745; GO:0005789; GO:0007601; GO:0042572; GO:0045494; GO:0052650; GO:0060342; GO:0102354; GO:0110095
GN006789	GN006789.1	Q96NR8	53.1	294	318	316	7.86e-101	301	RDH12_HUMAN	Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2)	Homo sapiens (Human)	cellular detoxification of aldehyde [GO:0110095]; photoreceptor cell maintenance [GO:0045494]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]	11-cis-retinol dehydrogenase (NADP+) activity [GO:0102354]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]	endoplasmic reticulum membrane [GO:0005789]; photoreceptor inner segment [GO:0001917]; photoreceptor inner segment membrane [GO:0060342]	GO:0001523; GO:0001917; GO:0004745; GO:0005789; GO:0007601; GO:0042572; GO:0045494; GO:0052650; GO:0060342; GO:0102354; GO:0110095
GN006790	GN006790.1	Q6R2W3	33.3	135	211	1325	6.34e-13	70.5	SCND3_HUMAN	SCAN domain-containing protein 3 (Transposon-derived Buster4 transposase-like protein) (Zinc finger BED domain-containing protein 9)	Homo sapiens (Human)	DNA integration [GO:0015074]; positive regulation of cell cycle [GO:0045787]; positive regulation of epithelial cell proliferation [GO:0050679]	nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003676; GO:0005634; GO:0005737; GO:0015074; GO:0045787; GO:0050679
GN006794	GN006794.1	Q96SZ5	33.8	207	194	270	4.62e-30	114	AEDO_HUMAN	2-aminoethanethiol dioxygenase (EC 1.13.11.19) (Cysteamine dioxygenase)	Homo sapiens (Human)	cellular response to hypoxia [GO:0071456]; taurine biosynthetic process [GO:0042412]	cysteamine dioxygenase activity [GO:0047800]; iron ion binding [GO:0005506]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0005506; GO:0005739; GO:0005829; GO:0042412; GO:0047800; GO:0071456
GN006795	GN006795.1	Q9QXW0	33.3	424	484	535	6.40e-47	173	FBXL6_MOUSE	F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6)	Mus musculus (Mouse)			SCF ubiquitin ligase complex [GO:0019005]	GO:0019005
GN006796	GN006796.1	Q6NWX7	54.6	218	220	223	4.14e-83	249	NTM1A_DANRE	N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A)	Danio rerio (Zebrafish) (Brachydanio rerio)	chromosome segregation [GO:0007059]; N-terminal peptidyl-glycine methylation [GO:0018013]; N-terminal peptidyl-proline dimethylation [GO:0018016]; N-terminal peptidyl-serine dimethylation [GO:0035572]; N-terminal peptidyl-serine trimethylation [GO:0035573]; spindle organization [GO:0007051]	histone methyltransferase activity [GO:0042054]; N-terminal protein N-methyltransferase activity [GO:0071885]; protein methyltransferase activity [GO:0008276]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0007051; GO:0007059; GO:0008276; GO:0018013; GO:0018016; GO:0035572; GO:0035573; GO:0042054; GO:0071885
GN006797	GN006797.1	Q2KID0	71.9	270	292	293	1.12e-134	385	EXOS2_BOVIN	Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4)	Bos taurus (Bovine)	CUT catabolic process [GO:0071034]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear-transcribed mRNA catabolic process [GO:0000956]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]; U4 snRNA 3'-end processing [GO:0034475]	RNA binding [GO:0003723]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0000176; GO:0000177; GO:0000178; GO:0000467; GO:0000956; GO:0003723; GO:0005654; GO:0005730; GO:0005829; GO:0030307; GO:0034475; GO:0071034; GO:0071035; GO:0071038; GO:0071051
GN006799	GN006799.1	Q9VBW3	48.3	294	977	773	3.18e-83	288	CAD96_DROME	Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14)	Drosophila melanogaster (Fruit fly)	calcium-dependent cell-cell adhesion [GO:0016339]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; Golgi organization [GO:0007030]; homophilic cell-cell adhesion [GO:0007156]; negative regulation of cell size [GO:0045792]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of wound healing [GO:0090303]; protein phosphorylation [GO:0006468]; wound healing [GO:0042060]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	apical part of cell [GO:0045177]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004713; GO:0004714; GO:0005509; GO:0005524; GO:0005886; GO:0006468; GO:0007030; GO:0007156; GO:0007169; GO:0016339; GO:0042060; GO:0043235; GO:0045177; GO:0045792; GO:0051897; GO:0090303
GN006800	GN006800.1	A4IHG1	51.5	132	208	349	1.19e-40	144	LRC58_XENTR	Leucine-rich repeat-containing protein 58	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of taurine biosynthetic process [GO:0062089]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]	GO:0005737; GO:0031466; GO:0043161; GO:0062089; GO:1990756
GN006801	GN006801.1	P40855	43.7	270	278	299	3.48e-54	180	PEX19_HUMAN	Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein)	Homo sapiens (Human)	establishment of protein localization to peroxisome [GO:0072663]; negative regulation of lipid binding [GO:1900131]; peroxisome fission [GO:0016559]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; protein folding [GO:0006457]; protein import into peroxisome membrane [GO:0045046]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625]	ATPase binding [GO:0051117]; peroxisome membrane class-1 targeting sequence binding [GO:0036105]; peroxisome membrane targeting sequence binding [GO:0033328]; protein carrier activity [GO:0140597]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	GO:0005634; GO:0005737; GO:0005777; GO:0005778; GO:0005829; GO:0006457; GO:0006625; GO:0007031; GO:0016020; GO:0016557; GO:0016559; GO:0031526; GO:0032991; GO:0033328; GO:0036105; GO:0045046; GO:0050821; GO:0051117; GO:0072663; GO:0140597; GO:1900131
GN006802	GN006802.1	P26153	28.9	287	383	470	4.51e-34	134	ACHB4_CHICK	Neuronal acetylcholine receptor subunit beta-4 (Neuronal acetylcholine receptor non-alpha-3 chain) (N-alpha 3)	Gallus gallus (Chicken)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0015464; GO:0022848; GO:0034220; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060
GN006803	GN006803.1	P26153	25.4	287	355	470	2.03e-22	101	ACHB4_CHICK	Neuronal acetylcholine receptor subunit beta-4 (Neuronal acetylcholine receptor non-alpha-3 chain) (N-alpha 3)	Gallus gallus (Chicken)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0015464; GO:0022848; GO:0034220; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060
GN006804	GN006804.1	A0A0L8FVQ9	28.5	361	380	399	3.81e-27	114	CRT1_OCTBM	Chemotactile receptor for terpenes 1 (CRT1)	Octopus bimaculoides (California two-spotted octopus)		extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; transmembrane signaling receptor activity [GO:0004888]	dendrite [GO:0030425]; membrane [GO:0016020]	GO:0004888; GO:0005230; GO:0016020; GO:0030425
GN006805	GN006805.1	Q8K0U4	35.1	627	609	675	4.33e-118	369	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN006807	GN006807.1	O15075	56.2	603	670	740	6.05e-210	609	DCLK1_HUMAN	Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)	Homo sapiens (Human)	axon extension [GO:0048675]; central nervous system development [GO:0007417]; endosomal transport [GO:0016197]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; protein phosphorylation [GO:0006468]; response to virus [GO:0009615]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005886; GO:0006468; GO:0007399; GO:0007417; GO:0009615; GO:0016197; GO:0035556; GO:0048675; GO:0106310
GN006808	GN006808.1	Q501I9	30.9	444	518	456	8.65e-68	228	DIRC2_XENTR	Solute carrier family 49 member 4 homolog (Disrupted in renal carcinoma protein 2 homolog)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	pyridoxine transport [GO:0031923]	transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]; membrane [GO:0016020]	GO:0005765; GO:0016020; GO:0022857; GO:0031923
GN006809	GN006809.1	Q5RGB8	24.8	588	692	605	1.72e-42	166	KLH26_DANRE	Kelch-like protein 26	Danio rerio (Zebrafish) (Brachydanio rerio)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]	GO:0031463; GO:0043161; GO:1990756
GN006810	GN006810.1	Q8K0U4	33.9	626	581	675	1.04e-105	335	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN006811	GN006811.1	Q96MM6	33.1	502	455	686	5.29e-71	240	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN006812	GN006812.1	Q8K0U4	32.3	623	580	675	4.77e-98	315	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN006813	GN006813.1	Q8N5T2	52.6	135	148	526	1.01e-40	145	TBC19_HUMAN	TBC1 domain family member 19	Homo sapiens (Human)				
GN006821	GN006821.1	A0A8M2B5N2	30.9	188	267	258	1.60e-15	77.4	TSN18_DANRE	Tetraspanin-18B	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of angiogenesis [GO:0045765]; regulation of sprouting angiogenesis [GO:1903670]		plasma membrane [GO:0005886]	GO:0005886; GO:0045765; GO:1903670
GN006822	GN006822.1	P61221	83.8	597	609	599	0.0	1021	ABCE1_HUMAN	ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I)	Homo sapiens (Human)	negative regulation of endoribonuclease activity [GO:0060702]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; translational initiation [GO:0006413]; translational termination [GO:0006415]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; CTPase activity [GO:0043273]; endoribonuclease inhibitor activity [GO:0060698]; GTPase activity [GO:0003924]; iron ion binding [GO:0005506]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; ribosomal small subunit binding [GO:0043024]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003924; GO:0005506; GO:0005524; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006413; GO:0006415; GO:0016020; GO:0016887; GO:0017111; GO:0022626; GO:0032790; GO:0043024; GO:0043273; GO:0060698; GO:0060702; GO:0072344
GN006828	GN006828.1	O43301	30.0	641	636	675	1.73e-82	276	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN006829	GN006829.1	O43301	28.4	640	590	675	3.40e-77	261	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN006830	GN006830.1	Q9Y496	66.1	669	705	699	1.86e-274	773	KIF3A_HUMAN	Kinesin-like protein KIF3A (EC 3.6.4.-) (Microtubule plus end-directed kinesin motor 3A)	Homo sapiens (Human)	anterograde axonal transport [GO:0008089]; centriole-centriole cohesion [GO:0010457]; cilium assembly [GO:0060271]; microtubule anchoring at centrosome [GO:0034454]; organelle organization [GO:0006996]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to cell junction [GO:1902414]; protein localization to non-motile cilium [GO:0097499]; protein transport [GO:0015031]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein phosphatase binding [GO:0019903]; small GTPase binding [GO:0031267]; spectrin binding [GO:0030507]	axon cytoplasm [GO:1904115]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; kinesin complex [GO:0005871]; kinesin II complex [GO:0016939]; microtubule cytoskeleton [GO:0015630]; non-motile cilium [GO:0097730]	GO:0003777; GO:0005524; GO:0005813; GO:0005814; GO:0005829; GO:0005871; GO:0005929; GO:0006996; GO:0008017; GO:0008089; GO:0008574; GO:0010457; GO:0015031; GO:0015630; GO:0016939; GO:0019903; GO:0030507; GO:0031267; GO:0034454; GO:0045880; GO:0060271; GO:0070062; GO:0072383; GO:0097499; GO:0097542; GO:0097730; GO:1902414; GO:1904115
GN006833	GN006833.1	F1R8P4	42.3	414	384	449	4.26e-108	327	GLRA2_DANRE	Glycine receptor subunit alpha-2	Danio rerio (Zebrafish) (Brachydanio rerio)	chloride transmembrane transport [GO:1902476]	excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; glycine binding [GO:0016594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity [GO:0022824]	glycinergic synapse [GO:0098690]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005231; GO:0005886; GO:0016594; GO:0022824; GO:0045202; GO:0045211; GO:0098690; GO:1902476
GN006835	GN006835.1	Q7T2C4	30.8	682	702	739	2.49e-100	327	S26A5_DANRE	Prestin (Solute carrier family 26 member 5)	Danio rerio (Zebrafish) (Brachydanio rerio)	chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; oxalate transport [GO:0019532]; regulation of membrane potential [GO:0042391]; sulfate transmembrane transport [GO:1902358]	chloride:bicarbonate antiporter activity [GO:0140900]; formate transmembrane transporter activity [GO:0015499]; monoatomic ion transmembrane transporter activity [GO:0015075]; oxalate transmembrane transporter activity [GO:0019531]; oxalate:chloride antiporter activity [GO:0160046]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:chloride antiporter activity [GO:0160044]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0006821; GO:0008271; GO:0015075; GO:0015116; GO:0015499; GO:0016020; GO:0019531; GO:0019532; GO:0042391; GO:0140900; GO:0160044; GO:0160046; GO:1902358; GO:1902476
GN006840	GN006840.1	Q75WE7	31.4	792	781	822	6.87e-105	343	VWA5A_RAT	von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) (Mast cell surface antigen 1) (Masa-1)	Rattus norvegicus (Rat)			nucleoplasm [GO:0005654]	GO:0005654
GN006843	GN006843.1	O00534	46.3	54	93	786	1.59e-09	56.2	VMA5A_HUMAN	von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein)	Homo sapiens (Human)			nucleoplasm [GO:0005654]	GO:0005654
GN006844	GN006844.1	Q75WE7	43.1	72	123	822	1.69e-11	63.2	VWA5A_RAT	von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) (Mast cell surface antigen 1) (Masa-1)	Rattus norvegicus (Rat)			nucleoplasm [GO:0005654]	GO:0005654
GN006845	GN006845.1	Q75WE7	42.4	85	127	822	2.39e-15	74.3	VWA5A_RAT	von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) (Mast cell surface antigen 1) (Masa-1)	Rattus norvegicus (Rat)			nucleoplasm [GO:0005654]	GO:0005654
GN006846	GN006846.1	Q75WE7	33.0	100	116	822	1.17e-10	60.5	VWA5A_RAT	von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) (Mast cell surface antigen 1) (Masa-1)	Rattus norvegicus (Rat)			nucleoplasm [GO:0005654]	GO:0005654
GN006848	GN006848.1	Q75WE7	31.0	855	878	822	1.19e-107	353	VWA5A_RAT	von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) (Mast cell surface antigen 1) (Masa-1)	Rattus norvegicus (Rat)			nucleoplasm [GO:0005654]	GO:0005654
GN006849	GN006849.1	P63157	66.9	130	305	327	1.58e-42	152	BARH1_MOUSE	BarH-like 1 homeobox protein (Bar-class homeodomain protein MBH2) (BarH-related homeobox protein 1)	Mus musculus (Mouse)	midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0001228; GO:0001764; GO:0005634; GO:0006357; GO:0007605; GO:0030901; GO:0043524; GO:0045944; GO:1990837
GN006850	GN006850.1	Q9BYN0	66.4	110	115	137	3.88e-49	155	SRXN1_HUMAN	Sulfiredoxin-1 (EC 1.8.98.2)	Homo sapiens (Human)	cellular response to oxidative stress [GO:0034599]; response to oxidative stress [GO:0006979]	oxidoreductase activity, acting on a sulfur group of donors [GO:0016667]; sulfiredoxin activity [GO:0032542]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]	GO:0005737; GO:0005789; GO:0005829; GO:0006979; GO:0016667; GO:0032542; GO:0034599
GN006851	GN006851.1	P40337	31.9	144	175	213	7.38e-17	77.8	VHL_HUMAN	von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)	Homo sapiens (Human)	amyloid fibril formation [GO:1990000]; cell morphogenesis [GO:0000902]; cellular response to hypoxia [GO:0071456]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of cellular response to hypoxia [GO:1900037]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]	DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]; protein serine/threonine kinase binding [GO:0120283]; transcription corepressor activity [GO:0003714]; transcription elongation factor activity [GO:0003711]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000122; GO:0000902; GO:0003711; GO:0003714; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005783; GO:0005829; GO:0005886; GO:0006355; GO:0006508; GO:0008285; GO:0009968; GO:0010468; GO:0010507; GO:0010629; GO:0016567; GO:0019899; GO:0031462; GO:0034244; GO:0043066; GO:0043161; GO:0045597; GO:0045893; GO:0046426; GO:0050821; GO:0060090; GO:0071456; GO:0120283; GO:0140297; GO:1900037; GO:1904262; GO:1990000; GO:1990756
GN006852	GN006852.1	Q8IYT2	32.5	745	730	770	6.00e-111	357	CMTR2_HUMAN	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296) (Cap methyltransferase 2) (Cap2 2'O-ribose methyltransferase 2) (HMTr2) (MTr2) (FtsJ methyltransferase domain-containing protein 1) (Protein adrift homolog)	Homo sapiens (Human)	7-methylguanosine mRNA capping [GO:0006370]	methyltransferase cap1 activity [GO:0004483]; methyltransferase cap2 activity [GO:0120550]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004483; GO:0005634; GO:0005737; GO:0006370; GO:0120550
GN006853	GN006853.1	Q9RAH6	31.9	248	402	301	2.30e-32	127	NAT_NOCUT	Isonocardicin synthase (EC 2.5.1.38) (Nocardicin 3-amino-3-carboxypropyltransferase)	Nocardia uniformis subsp. tsuyamanensis		isonocardicin synthase activity [GO:0050007]		GO:0050007
GN006854	GN006854.1	Q9DCD2	65.3	841	854	855	0.0	1115	SYF1_MOUSE	Pre-mRNA-splicing factor SYF1 (XPA-binding protein 2)	Mus musculus (Mouse)	blastocyst development [GO:0001824]; cerebral cortex development [GO:0021987]; DNA-templated transcription [GO:0006351]; generation of catalytic spliceosome for first transesterification step [GO:0000349]; mRNA splicing, via spliceosome [GO:0000398]; transcription-coupled nucleotide-excision repair [GO:0006283]		catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000349; GO:0000398; GO:0000974; GO:0001824; GO:0005634; GO:0005654; GO:0005681; GO:0006283; GO:0006351; GO:0021987; GO:0071006; GO:0071007; GO:0071013; GO:0071014; GO:0071020
GN006859	GN006859.1	Q9CW79	33.3	198	900	758	2.09e-19	97.4	GOGA1_MOUSE	Golgin subfamily A member 1 (Golgin-97)	Mus musculus (Mouse)	cell-cell adhesion mediated by cadherin [GO:0044331]; transepithelial transport [GO:0070633]	molecular carrier activity [GO:0140104]	acrosomal vesicle [GO:0001669]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0001669; GO:0005794; GO:0005802; GO:0044331; GO:0048471; GO:0070633; GO:0140104
GN006860	GN006860.1	O02768	59.5	412	489	604	9.22e-187	538	PGH2_RABIT	Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)	Oryctolagus cuniculus (Rabbit)	brown fat cell differentiation [GO:0050873]; cellular response to hypoxia [GO:0071456]; cellular response to non-ionic osmotic stress [GO:0071471]; cyclooxygenase pathway [GO:0019371]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of fever generation [GO:0031622]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; prostaglandin biosynthetic process [GO:0001516]; regulation of blood pressure [GO:0008217]; regulation of neuroinflammatory response [GO:0150077]; response to oxidative stress [GO:0006979]	enzyme binding [GO:0019899]; heme binding [GO:0020037]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; peroxidase activity [GO:0004601]; prostaglandin-endoperoxide synthase activity [GO:0004666]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; neuron projection [GO:0043005]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]	GO:0001516; GO:0004601; GO:0004666; GO:0005637; GO:0005640; GO:0005737; GO:0005788; GO:0005789; GO:0006979; GO:0008217; GO:0016702; GO:0019371; GO:0019899; GO:0020037; GO:0031394; GO:0031622; GO:0042803; GO:0043005; GO:0050873; GO:0071456; GO:0071471; GO:0090336; GO:0150077; GO:1902219
GN006861	GN006861.1	P49147	46.2	736	766	748	1.32e-220	640	PA24A_CHICK	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]	Gallus gallus (Chicken)	arachidonate metabolic process [GO:0019369]; arachidonate secretion [GO:0050482]; glycerophospholipid catabolic process [GO:0046475]; leukotriene biosynthetic process [GO:0019370]; monoacylglycerol biosynthetic process [GO:0006640]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylglycerol catabolic process [GO:0034478]; platelet activating factor biosynthetic process [GO:0006663]; positive regulation of macrophage activation [GO:0043032]; positive regulation of platelet activation [GO:0010572]; positive regulation of T-helper 1 type immune response [GO:0002827]; prostaglandin biosynthetic process [GO:0001516]	A2-type glycerophospholipase activity [GO:0004623]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; ceramide 1-phosphate binding [GO:1902387]; phosphatidylcholine lysophospholipase A1 activity [GO:0004622]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]	GO:0000139; GO:0001516; GO:0002827; GO:0004622; GO:0004623; GO:0005509; GO:0005544; GO:0005634; GO:0005635; GO:0005783; GO:0005794; GO:0005829; GO:0006640; GO:0006663; GO:0010314; GO:0010572; GO:0016747; GO:0019369; GO:0019370; GO:0031410; GO:0032266; GO:0034478; GO:0034638; GO:0036151; GO:0043032; GO:0046475; GO:0050482; GO:0070273; GO:1902387
GN006862	GN006862.1	Q5T4S7	58.7	2204	2191	5183	0.0	2537	UBR4_HUMAN	E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600)	Homo sapiens (Human)	cytoplasm protein quality control [GO:0140455]; cytoplasm protein quality control by the ubiquitin-proteasome system [GO:0071629]; endosome organization [GO:0007032]; HRI-mediated signaling [GO:0140468]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of HRI-mediated signaling [GO:0141191]; positive regulation of autophagy [GO:0010508]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; response to oxidative stress [GO:0006979]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596]	calmodulin binding [GO:0005516]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005516; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0005856; GO:0005886; GO:0006511; GO:0006515; GO:0006979; GO:0007032; GO:0008270; GO:0010508; GO:0016020; GO:0035579; GO:0043161; GO:0044314; GO:0045717; GO:0061630; GO:0070821; GO:0070936; GO:0070979; GO:0071596; GO:0071629; GO:0101003; GO:0140455; GO:0140468; GO:0141191; GO:0141198; GO:1990756
GN006863	GN006863.1	Q5T4S7	45.4	2852	2855	5183	0.0	2140	UBR4_HUMAN	E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600)	Homo sapiens (Human)	cytoplasm protein quality control [GO:0140455]; cytoplasm protein quality control by the ubiquitin-proteasome system [GO:0071629]; endosome organization [GO:0007032]; HRI-mediated signaling [GO:0140468]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of HRI-mediated signaling [GO:0141191]; positive regulation of autophagy [GO:0010508]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; response to oxidative stress [GO:0006979]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596]	calmodulin binding [GO:0005516]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome [GO:0005768]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005516; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0005856; GO:0005886; GO:0006511; GO:0006515; GO:0006979; GO:0007032; GO:0008270; GO:0010508; GO:0016020; GO:0035579; GO:0043161; GO:0044314; GO:0045717; GO:0061630; GO:0070821; GO:0070936; GO:0070979; GO:0071596; GO:0071629; GO:0101003; GO:0140455; GO:0140468; GO:0141191; GO:0141198; GO:1990756
GN006864	GN006864.1	Q5XKL5	31.2	372	810	1792	3.08e-52	201	BTBD8_HUMAN	BTB/POZ domain-containing protein 8 (AP2-interacting clathrin-endocytosis) (APache)	Homo sapiens (Human)	synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle endocytosis [GO:0048488]		AP-2 adaptor complex [GO:0030122]; axon [GO:0030424]; extrinsic component of synaptic vesicle membrane [GO:0098850]; neuron projection terminus [GO:0044306]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0016182; GO:0030122; GO:0030424; GO:0044306; GO:0048488; GO:0098850
GN006865	GN006865.1	P09118	49.8	295	302	303	9.38e-105	310	URIC_RAT	Uricase (EC 1.7.3.3) (Urate oxidase)	Rattus norvegicus (Rat)	purine nucleobase catabolic process [GO:0006145]; urate catabolic process [GO:0019628]	urate oxidase activity [GO:0004846]	peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0004846; GO:0005777; GO:0005782; GO:0006145; GO:0019628
GN006866	GN006866.1	D3YZI9	33.1	121	235	523	3.87e-09	59.7	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN006867	GN006867.1	Q0VFN8	42.8	465	561	519	3.57e-82	269	CF157_XENTR	Cilia- and flagella-associated protein 157	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	sperm axoneme assembly [GO:0007288]	microtubule binding [GO:0008017]	ciliary basal body [GO:0036064]	GO:0007288; GO:0008017; GO:0036064
GN006868	GN006868.1	Q92506	51.8	253	246	261	3.53e-80	244	DHB8_HUMAN	(3R)-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (HSD17B8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (Estradiol 17-beta-dehydrogenase 8) (EC 1.1.1.62) (Protein Ke6) (Ke6) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)	Homo sapiens (Human)	estrogen biosynthetic process [GO:0006703]; fatty acid biosynthetic process [GO:0006633]; protein heterotetramerization [GO:0051290]	(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0106386]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; NADH binding [GO:0070404]; quinone binding [GO:0048038]; testosterone dehydrogenase (NAD+) activity [GO:0047035]	endoplasmic reticulum [GO:0005783]; mitochondrial envelope [GO:0005740]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxidoreductase complex [GO:1990204]; plasma membrane [GO:0005886]	GO:0004303; GO:0005739; GO:0005740; GO:0005759; GO:0005783; GO:0005886; GO:0006633; GO:0006703; GO:0047035; GO:0048038; GO:0051290; GO:0070404; GO:0106386; GO:1990204
GN006873	GN006873.1	Q5RJU3	43.9	196	226	225	2.00e-41	143	DAA19_XENTR	Dynein axonemal assembly factor 19 (Coiled-coil domain-containing protein 103)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; inner dynein arm assembly [GO:0036159]		cytoplasm [GO:0005737]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; outer dynein arm [GO:0036157]	GO:0003351; GO:0005576; GO:0005737; GO:0007368; GO:0031514; GO:0036157; GO:0036159
GN006880	GN006880.1	A7MAZ3	87.1	62	422	404	6.92e-29	120	UBA5_BOVIN	Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (UFM1-activating enzyme)	Bos taurus (Bovine)	erythrocyte differentiation [GO:0030218]; megakaryocyte differentiation [GO:0030219]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]	protein homodimerization activity [GO:0042803]; UFM1 activating enzyme activity [GO:0071566]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005789; GO:0005794; GO:0005829; GO:0008270; GO:0030218; GO:0030219; GO:0033146; GO:0034976; GO:0042803; GO:0061709; GO:0071566; GO:0071569; GO:1990592
GN006881	GN006881.1	Q8VE47	55.9	111	109	403	2.30e-30	114	UBA5_MOUSE	Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (UFM1-activating enzyme)	Mus musculus (Mouse)	erythrocyte differentiation [GO:0030218]; megakaryocyte differentiation [GO:0030219]; neuromuscular process [GO:0050905]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of type II interferon production [GO:0032649]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]	protein homodimerization activity [GO:0042803]; UFM1 activating enzyme activity [GO:0071566]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005789; GO:0005794; GO:0005829; GO:0008270; GO:0030218; GO:0030219; GO:0032649; GO:0033146; GO:0034976; GO:0042803; GO:0050905; GO:0061709; GO:0071566; GO:0071569; GO:1990592
GN006882	GN006882.1	Q9BYW2	37.3	1124	4412	2564	1.91e-160	563	SETD2_HUMAN	Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)	Homo sapiens (Human)	defense response to virus [GO:0051607]; endodermal cell differentiation [GO:0035987]; microtubule cytoskeleton organization involved in mitosis [GO:1902850]; mismatch repair [GO:0006298]; nucleosome organization [GO:0034728]; peptidyl-lysine trimethylation [GO:0018023]; positive regulation of autophagy [GO:0010508]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of ossification [GO:0045778]; regulation of cytokinesis [GO:0032465]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of gene expression [GO:0010468]; regulation of mRNA export from nucleus [GO:0010793]; regulation of protein localization to chromatin [GO:1905634]; response to alkaloid [GO:0043279]; response to metal ion [GO:0010038]; response to type I interferon [GO:0034340]; stem cell differentiation [GO:0048863]; transcription elongation by RNA polymerase II [GO:0006368]	alpha-tubulin binding [GO:0043014]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; protein-lysine N-methyltransferase activity [GO:0016279]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006298; GO:0006355; GO:0006368; GO:0010038; GO:0010468; GO:0010508; GO:0010569; GO:0010793; GO:0016279; GO:0018023; GO:0032465; GO:0032727; GO:0034340; GO:0034728; GO:0035987; GO:0043014; GO:0043279; GO:0045778; GO:0046975; GO:0048863; GO:0051607; GO:0140938; GO:0140955; GO:1902850; GO:1905634
GN006883	GN006883.1	P42678	70.0	100	119	110	7.28e-45	144	ETIF1_ANOGA	Eukaryotic translation initiation factor eIF1 (Protein translation factor SUI1 homolog)	Anopheles gambiae (African malaria mosquito)		ribosomal small subunit binding [GO:0043024]; translation initiation factor activity [GO:0003743]	eukaryotic 43S preinitiation complex [GO:0016282]	GO:0003743; GO:0016282; GO:0043024
GN006884	GN006884.1	Q8K1N4	33.4	440	772	545	1.05e-40	160	SPAS2_MOUSE	Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr)	Mus musculus (Mouse)			cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829
GN006885	GN006885.1	F1P4W9	38.5	1777	1794	1775	0.0	1201	CFA65_CHICK	Cilia- and flagella-associated protein 65 (Coiled-coil domain-containing protein 108)	Gallus gallus (Chicken)	acrosome assembly [GO:0001675]; cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]; sperm axoneme assembly [GO:0007288]; sperm mitochondrial sheath assembly [GO:0120317]; spermatogenesis [GO:0007283]		acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; axonemal central apparatus [GO:1990716]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]	GO:0001669; GO:0001675; GO:0002080; GO:0003341; GO:0005737; GO:0007283; GO:0007288; GO:0030317; GO:0036126; GO:0097225; GO:0120317; GO:1990716
GN006887	GN006887.1	Q68CR1	31.8	964	993	1132	1.18e-150	479	SE1L3_HUMAN	Protein sel-1 homolog 3 (Suppressor of lin-12-like protein 3) (Sel-1L3)	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN006892	GN006892.1	Q6ZMT9	21.5	578	1739	781	2.28e-09	66.2	DTHD1_HUMAN	Death domain-containing protein 1	Homo sapiens (Human)	signal transduction [GO:0007165]			GO:0007165
GN006893	GN006893.1	Q5RGB8	23.9	305	367	605	5.85e-15	79.7	KLH26_DANRE	Kelch-like protein 26	Danio rerio (Zebrafish) (Brachydanio rerio)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]	GO:0031463; GO:0043161; GO:1990756
GN006896	GN006896.1	O43805	65.3	49	52	119	2.91e-13	61.6	SSNA1_HUMAN	Microtubule nucleation factor SSNA1 (Nuclear autoantigen of 14 kDa) (Sjoegren syndrome nuclear autoantigen 1)	Homo sapiens (Human)	axon arborization [GO:0140060]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; cell division [GO:0051301]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	axon [GO:0030424]; axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634]; supramolecular fiber [GO:0099512]	GO:0000226; GO:0005634; GO:0005813; GO:0005814; GO:0005829; GO:0005930; GO:0007020; GO:0007409; GO:0008017; GO:0030424; GO:0030496; GO:0036064; GO:0042802; GO:0048675; GO:0051301; GO:0099512; GO:0140060
GN006897	GN006897.1	O95999	35.1	114	170	233	6.52e-11	62.0	BCL10_HUMAN	B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10)	Homo sapiens (Human)	adaptive immune response [GO:0002250]; antifungal innate immune response [GO:0061760]; apoptotic signaling pathway [GO:0097190]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of mature B cell apoptotic process [GO:0002906]; neural tube closure [GO:0001843]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lymphotoxin A production [GO:0032761]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell receptor signaling pathway [GO:0050862]; programmed cell death [GO:0012501]; protein homooligomerization [GO:0051260]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; response to food [GO:0032094]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor signaling pathway [GO:0002224]	CARD domain binding [GO:0050700]; general transcription initiation factor binding [GO:0140296]; identical protein binding [GO:0042802]; NF-kappaB binding [GO:0051059]; protease binding [GO:0002020]; protein kinase B binding [GO:0043422]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; signaling adaptor activity [GO:0035591]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]	CBM complex [GO:0032449]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; lysosome [GO:0005764]; membrane raft [GO:0045121]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polkadots [GO:0002096]; protein-containing complex [GO:0032991]	GO:0001772; GO:0001843; GO:0002020; GO:0002096; GO:0002224; GO:0002250; GO:0002906; GO:0003713; GO:0005634; GO:0005737; GO:0005764; GO:0005829; GO:0005881; GO:0012501; GO:0030674; GO:0031398; GO:0031625; GO:0031663; GO:0032094; GO:0032449; GO:0032755; GO:0032757; GO:0032761; GO:0032765; GO:0032991; GO:0035591; GO:0038061; GO:0042802; GO:0043065; GO:0043122; GO:0043123; GO:0043422; GO:0044877; GO:0045087; GO:0045121; GO:0045893; GO:0048471; GO:0050700; GO:0050852; GO:0050862; GO:0051059; GO:0051260; GO:0061760; GO:0071222; GO:0071260; GO:0097190; GO:0140296; GO:2001238
GN006902	GN006902.1	P31316	64.6	96	275	305	1.28e-28	114	GSX2_MOUSE	GS homeobox 2 (Genetic-screened homeobox 2) (Homeobox protein GSH-2)	Mus musculus (Mouse)	brain development [GO:0007420]; central nervous system development [GO:0007417]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain morphogenesis [GO:0048853]; generation of neurons [GO:0048699]; hindbrain morphogenesis [GO:0021575]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; olfactory bulb development [GO:0021772]; olfactory bulb interneuron differentiation [GO:0021889]; pattern specification process [GO:0007389]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of cell migration [GO:0030334]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; spinal cord association neuron differentiation [GO:0021527]; subpallium development [GO:0021544]; subpallium neuron fate commitment [GO:0060163]; telencephalon regionalization [GO:0021978]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000981; GO:0002087; GO:0003677; GO:0005634; GO:0005737; GO:0007389; GO:0007417; GO:0007420; GO:0021527; GO:0021544; GO:0021575; GO:0021772; GO:0021798; GO:0021889; GO:0021978; GO:0030334; GO:0045747; GO:0048663; GO:0048665; GO:0048699; GO:0048714; GO:0048853; GO:0060163; GO:1990837
GN006905	GN006905.1	Q91755	31.7	815	843	913	5.80e-99	332	GRIK2_XENLA	Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)	Xenopus laevis (African clawed frog)	detection of cold stimulus involved in thermoception [GO:0120169]; modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]	extracellularly glutamate-gated ion channel activity [GO:0005234]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	kainate selective glutamate receptor complex [GO:0032983]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]	GO:0004970; GO:0005234; GO:0005886; GO:0015277; GO:0022849; GO:0032983; GO:0035249; GO:0042734; GO:0050804; GO:0098839; GO:0120169; GO:1904315
GN006908	GN006908.1	P48058	32.2	736	810	902	2.68e-117	379	GRIA4_HUMAN	Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4)	Homo sapiens (Human)	glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; synaptic transmission, glutamatergic [GO:0035249]	AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; glutamate-gated receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	AMPA glutamate receptor complex [GO:0032281]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; extracellular vesicle [GO:1903561]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]	GO:0001540; GO:0004970; GO:0004971; GO:0005886; GO:0007215; GO:0030425; GO:0030666; GO:0032281; GO:0034392; GO:0035249; GO:0043025; GO:0043197; GO:0045211; GO:0050804; GO:0098839; GO:0099507; GO:1903561; GO:1904315
GN006909	GN006909.1	A2AU72	43.3	939	906	881	1.11e-153	477	ARMC3_MOUSE	Armadillo repeat-containing protein 3	Mus musculus (Mouse)	flagellated sperm motility [GO:0030317]; ribophagy [GO:0034517]; spermatid development [GO:0007286]			GO:0007286; GO:0030317; GO:0034517
GN006915	GN006915.1	O15457	56.3	728	963	936	2.81e-283	815	MSH4_HUMAN	MutS protein homolog 4 (hMSH4)	Homo sapiens (Human)	mismatch repair [GO:0006298]; reciprocal meiotic recombination [GO:0007131]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; mismatched DNA binding [GO:0030983]	chromosome [GO:0005694]; DNA repair complex [GO:1990391]; nucleus [GO:0005634]; recombination nodule [GO:0005713]; synaptonemal complex [GO:0000795]	GO:0000795; GO:0003677; GO:0005524; GO:0005634; GO:0005694; GO:0005713; GO:0006298; GO:0007131; GO:0030983; GO:0140664; GO:1990391
GN006920	GN006920.1	A0A1D3PCM3	48.2	454	493	517	8.56e-141	417	SST_EMEND	Serine O-succinyltransferase (SST) (EC 2.3.1.-)	Emericella nidulans (Aspergillus nidulans)	L-cysteine biosynthetic process [GO:0019344]; L-homoserine metabolic process [GO:0009092]	homoserine O-acetyltransferase activity [GO:0004414]; L-serine O-acetyltransferase activity [GO:0009001]; L-serine O-succinyltransferase activity [GO:0160210]	mitochondrion [GO:0005739]	GO:0004414; GO:0005739; GO:0009001; GO:0009092; GO:0019344; GO:0160210
GN006923	GN006923.1	P20478	71.5	354	361	369	6.58e-205	569	GLNA2_DROME	Glutamine synthetase 2, cytoplasmic (GS-c) (EC 6.3.1.2) (Glutamate--ammonia ligase 2)	Drosophila melanogaster (Fruit fly)	L-glutamate catabolic process [GO:0006538]; L-glutamine biosynthetic process [GO:1901704]; synapse assembly [GO:0007416]	glutamine synthetase activity [GO:0004356]	cytosol [GO:0005829]	GO:0004356; GO:0005829; GO:0006538; GO:0007416; GO:1901704
GN006925	GN006925.1	Q9D489	55.7	61	568	467	6.33e-13	74.7	SOLH2_MOUSE	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2	Mus musculus (Mouse)	cell differentiation [GO:0030154]; oocyte differentiation [GO:0009994]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary ovarian follicle growth [GO:0001545]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0001228; GO:0001545; GO:0005634; GO:0005737; GO:0006357; GO:0007283; GO:0009994; GO:0010468; GO:0030154; GO:0042802; GO:0042803; GO:0045944; GO:0046982; GO:1990837
GN006931	GN006931.1	D4AE59	32.4	225	408	436	7.66e-28	117	STK11_RAT	Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1 homolog) (LKB1)	Rattus norvegicus (Rat)	activation of protein kinase activity [GO:0032147]; anoikis [GO:0043276]; axonogenesis [GO:0007409]; cellular response to glucose starvation [GO:0042149]; cellular response to UV-B [GO:0071493]; dendrite extension [GO:0097484]; DNA damage response [GO:0006974]; establishment of cell polarity [GO:0030010]; G1 to G0 transition [GO:0070314]; glucose homeostasis [GO:0042593]; Golgi localization [GO:0051645]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of TORC1 signaling [GO:1904262]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagy [GO:0010508]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cellular senescence [GO:2000774]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of vesicle transport along microtubule [GO:1901610]; positive thymic T cell selection [GO:0045059]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of dendrite morphogenesis [GO:0048814]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of Wnt signaling pathway [GO:0030111]; response to activity [GO:0014823]; response to glucagon [GO:0033762]; response to ionizing radiation [GO:0010212]; response to lipid [GO:0033993]; response to peptide hormone [GO:0043434]; response to thyroid hormone [GO:0097066]; spermatid development [GO:0007286]; T cell receptor signaling pathway [GO:0050852]; tissue homeostasis [GO:0001894]; vasculature development [GO:0001944]	ATP binding [GO:0005524]; LRR domain binding [GO:0030275]; magnesium ion binding [GO:0000287]; p53 binding [GO:0002039]; protein kinase activator activity [GO:0030295]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular protein-containing complex [GO:0140535]; late endosome [GO:0005770]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; Z disc [GO:0030018]	GO:0000287; GO:0001558; GO:0001894; GO:0001944; GO:0002039; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005770; GO:0005829; GO:0006468; GO:0006470; GO:0006974; GO:0007286; GO:0007409; GO:0008285; GO:0010212; GO:0010508; GO:0014823; GO:0016020; GO:0018107; GO:0030010; GO:0030018; GO:0030111; GO:0030275; GO:0030295; GO:0030308; GO:0030511; GO:0032147; GO:0032991; GO:0033762; GO:0033993; GO:0042149; GO:0042593; GO:0043276; GO:0043434; GO:0044877; GO:0045059; GO:0045722; GO:0046777; GO:0048814; GO:0050772; GO:0050852; GO:0051645; GO:0051896; GO:0060770; GO:0070314; GO:0071493; GO:0072332; GO:0090090; GO:0097066; GO:0097484; GO:0106310; GO:0120163; GO:0140535; GO:1900182; GO:1901610; GO:1904262; GO:2000774
GN006932	GN006932.1	Q9H9B1	33.4	296	1518	1298	9.29e-40	165	EHMT1_HUMAN	Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D)	Homo sapiens (Human)	beige fat cell differentiation [GO:0160274]; brown fat cell differentiation [GO:0050873]; chromatin organization [GO:0006325]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of white fat cell differentiation [GO:0160275]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of embryonic development [GO:0045995]; response to fungicide [GO:0060992]	histone H3K27 methyltransferase activity [GO:0046976]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone H3K9me2 methyltransferase activity [GO:0140947]; methyltransferase activity [GO:0008168]; p53 binding [GO:0002039]; protein-lysine N-methyltransferase activity [GO:0016279]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0001222; GO:0002039; GO:0005634; GO:0005654; GO:0005694; GO:0006325; GO:0006346; GO:0008168; GO:0008270; GO:0016279; GO:0016604; GO:0018026; GO:0018027; GO:0040029; GO:0045892; GO:0045995; GO:0046974; GO:0046976; GO:0050873; GO:0060992; GO:0120162; GO:0140947; GO:0140948; GO:0140949; GO:0160274; GO:0160275
GN006934	GN006934.1	R9UTQ8	28.5	235	287	268	3.37e-21	93.6	PROHY_STRGD	L-proline trans-4-hydroxylase (P4H) (EC 1.14.11.57)	Streptomyces griseoviridis	antibiotic metabolic process [GO:0016999]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506]		GO:0005506; GO:0016706; GO:0016999
GN006937	GN006937.1	P10155	30.7	537	545	538	2.53e-72	243	RO60_HUMAN	RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2)	Homo sapiens (Human)	cellular response to interferon-alpha [GO:0035457]; regulation of gene expression [GO:0010468]; transcription by RNA polymerase III [GO:0006383]	RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005634; GO:0005737; GO:0005829; GO:0006383; GO:0010468; GO:0030620; GO:0035457; GO:1990904
GN006938	GN006938.1	Q25532	60.0	115	116	117	2.07e-15	69.7	VATG_MANSE	V-type proton ATPase subunit G (V-ATPase subunit G) (V-ATPase 13 kDa subunit) (Vacuolar proton pump subunit G)	Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)	synaptic vesicle lumen acidification [GO:0097401]	ATP hydrolysis activity [GO:0016887]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical plasma membrane [GO:0016324]; presynapse [GO:0098793]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	GO:0000221; GO:0016324; GO:0016887; GO:0046961; GO:0097401; GO:0098793
GN006939	GN006939.1	Q9HD20	61.2	1162	1171	1204	0.0	1349	AT131_HUMAN	Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase)	Homo sapiens (Human)	extraction of mislocalized protein from ER membrane [GO:0140569]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; transmembrane transport [GO:0055085]	ABC-type manganese transporter activity [GO:0015410]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; membrane protein dislocase activity [GO:0140567]; P-type ion transporter activity [GO:0015662]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0005524; GO:0005789; GO:0006874; GO:0015410; GO:0015662; GO:0016020; GO:0016887; GO:0019829; GO:0034220; GO:0055085; GO:0140567; GO:0140569
GN006940	GN006940.1	A0QYL8	23.3	365	517	429	3.02e-20	96.7	MFSEP_MYCS2	MFS-type efflux pump MSMEG_3705	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)		transmembrane transporter activity [GO:0022857]	plasma membrane [GO:0005886]	GO:0005886; GO:0022857
GN006941	GN006941.1	P40427	73.7	353	471	376	2.24e-154	446	EXD_DROME	Homeobox protein extradenticle (Dpbx)	Drosophila melanogaster (Fruit fly)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; oenocyte development [GO:0007438]; peripheral nervous system development [GO:0007422]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell fate specification [GO:0042659]; regulation of transcription by RNA polymerase II [GO:0006357]; salivary gland boundary specification [GO:0007432]; somatic muscle development [GO:0007525]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	GO:0000978; GO:0000981; GO:0000987; GO:0001228; GO:0001654; GO:0003677; GO:0003700; GO:0003712; GO:0003713; GO:0005634; GO:0005667; GO:0005737; GO:0006357; GO:0007420; GO:0007422; GO:0007432; GO:0007438; GO:0007525; GO:0009887; GO:0032993; GO:0042659; GO:0043565; GO:0045893; GO:0045944; GO:0046982; GO:0048568; GO:0048666; GO:0090575; GO:0140297
GN006942	GN006942.1	Q9H0W7	40.0	85	291	228	5.08e-09	58.9	THAP2_HUMAN	THAP domain-containing protein 2	Homo sapiens (Human)			nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730
GN006943	GN006943.1	Q9Y6R7	22.1	390	643	5405	2.06e-12	74.7	FCGBP_HUMAN	IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP)	Homo sapiens (Human)		extracellular matrix structural constituent [GO:0005201]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; Golgi lumen [GO:0005796]	GO:0005201; GO:0005796; GO:0031012; GO:0070062
GN006944	GN006944.1	D8VNS7	52.2	182	293	345	2.31e-58	193	FCNV1_CERRY	Ryncolin-1	Cerberus rynchops (Dog-faced water snake)	complement activation, lectin pathway [GO:0001867]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0001867; GO:0003823; GO:0005102; GO:0005576; GO:0097367
GN006945	GN006945.1	Q8VHQ2	55.7	167	1142	579	6.73e-55	205	SOCS7_MOUSE	Suppressor of cytokine signaling 7 (SOCS-7)	Mus musculus (Mouse)	cerebral cortex radially oriented cell migration [GO:0021799]; fat cell differentiation [GO:0045444]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; layer formation in cerebral cortex [GO:0021819]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; radial glia guided migration of Purkinje cell [GO:0021942]	phosphorylation-dependent protein binding [GO:0140031]; signaling adaptor activity [GO:0035591]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0008286; GO:0016567; GO:0021799; GO:0021819; GO:0021942; GO:0031466; GO:0035556; GO:0035591; GO:0043161; GO:0045444; GO:0140031; GO:1990756
GN006947	GN006947.1	Q9P2G1	51.6	748	1340	1089	2.11e-262	780	AKIB1_HUMAN	Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31)	Homo sapiens (Human)	protein ubiquitination [GO:0016567]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005829; GO:0005886; GO:0008270; GO:0016567; GO:0031624; GO:0061630
GN006950	GN006950.1	P18503	29.6	179	234	366	2.32e-09	60.1	CAS4_EPHMU	Short-chain collagen C4	Ephydatia muelleri (Mueller's freshwater sponge) (Spongilla muelleri)			extracellular matrix [GO:0031012]	GO:0031012
GN006954	GN006954.1	P18503	29.6	179	205	366	1.38e-09	60.1	CAS4_EPHMU	Short-chain collagen C4	Ephydatia muelleri (Mueller's freshwater sponge) (Spongilla muelleri)			extracellular matrix [GO:0031012]	GO:0031012
GN006957	GN006957.1	P18503	29.6	179	205	366	1.38e-09	60.1	CAS4_EPHMU	Short-chain collagen C4	Ephydatia muelleri (Mueller's freshwater sponge) (Spongilla muelleri)			extracellular matrix [GO:0031012]	GO:0031012
GN006959	GN006959.1	P35342	24.4	303	326	317	1.79e-12	70.5	AA3R_SHEEP	Adenosine receptor A3	Ovis aries (Sheep)	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; positive regulation of mast cell degranulation [GO:0043306]	G protein-coupled adenosine receptor activity [GO:0001609]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0001609; GO:0005886; GO:0007193; GO:0030425; GO:0043306; GO:0045202
GN006960	GN006960.1	O02777	27.9	298	303	472	3.98e-14	75.9	CNR1_FELCA	Cannabinoid receptor 1 (CB-R) (CB1)	Felis catus (Cat) (Felis silvestris catus)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]	cannabinoid receptor activity [GO:0004949]; G protein-coupled receptor activity [GO:0004930]	axon [GO:0030424]; cytoplasm [GO:0005737]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0004930; GO:0004949; GO:0005737; GO:0005741; GO:0005886; GO:0007188; GO:0007189; GO:0030424; GO:0045121; GO:0098793
GN006962	GN006962.1	Q15058	59.8	276	559	1648	6.49e-95	320	KIF14_HUMAN	Kinesin-like protein KIF14	Homo sapiens (Human)	activation of protein kinase activity [GO:0032147]; cell division [GO:0051301]; cell proliferation in forebrain [GO:0021846]; cerebellar cortex development [GO:0021695]; cerebellar granular layer structural organization [GO:0021685]; cerebellar Purkinje cell layer structural organization [GO:0021693]; cerebral cortex development [GO:0021987]; establishment of protein localization [GO:0045184]; hippocampus development [GO:0021766]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of integrin activation [GO:0033624]; negative regulation of neuron apoptotic process [GO:0043524]; olfactory bulb development [GO:0021772]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of cell growth [GO:0001558]; regulation of cell maturation [GO:1903429]; regulation of cell migration [GO:0030334]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of myelination [GO:0031641]; regulation of neuron apoptotic process [GO:0043523]; regulation of Rap protein signal transduction [GO:0032487]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; substrate adhesion-dependent cell spreading [GO:0034446]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; PDZ domain binding [GO:0030165]; plus-end-directed microtubule motor activity [GO:0008574]; protein kinase binding [GO:0019901]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle midzone [GO:0051233]	GO:0001558; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005871; GO:0005874; GO:0007018; GO:0007080; GO:0008017; GO:0008284; GO:0008574; GO:0010389; GO:0015631; GO:0016020; GO:0016887; GO:0019901; GO:0021685; GO:0021693; GO:0021695; GO:0021766; GO:0021772; GO:0021846; GO:0021987; GO:0030155; GO:0030165; GO:0030334; GO:0030496; GO:0031146; GO:0031641; GO:0032147; GO:0032467; GO:0032487; GO:0033624; GO:0034446; GO:0043066; GO:0043161; GO:0043523; GO:0043524; GO:0045184; GO:0051233; GO:0051301; GO:1903429; GO:2000045
GN006963	GN006963.1	Q15058	33.9	826	914	1648	2.76e-103	356	KIF14_HUMAN	Kinesin-like protein KIF14	Homo sapiens (Human)	activation of protein kinase activity [GO:0032147]; cell division [GO:0051301]; cell proliferation in forebrain [GO:0021846]; cerebellar cortex development [GO:0021695]; cerebellar granular layer structural organization [GO:0021685]; cerebellar Purkinje cell layer structural organization [GO:0021693]; cerebral cortex development [GO:0021987]; establishment of protein localization [GO:0045184]; hippocampus development [GO:0021766]; microtubule-based movement [GO:0007018]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of integrin activation [GO:0033624]; negative regulation of neuron apoptotic process [GO:0043524]; olfactory bulb development [GO:0021772]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of cell growth [GO:0001558]; regulation of cell maturation [GO:1903429]; regulation of cell migration [GO:0030334]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of myelination [GO:0031641]; regulation of neuron apoptotic process [GO:0043523]; regulation of Rap protein signal transduction [GO:0032487]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; substrate adhesion-dependent cell spreading [GO:0034446]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; PDZ domain binding [GO:0030165]; plus-end-directed microtubule motor activity [GO:0008574]; protein kinase binding [GO:0019901]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle midzone [GO:0051233]	GO:0001558; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005871; GO:0005874; GO:0007018; GO:0007080; GO:0008017; GO:0008284; GO:0008574; GO:0010389; GO:0015631; GO:0016020; GO:0016887; GO:0019901; GO:0021685; GO:0021693; GO:0021695; GO:0021766; GO:0021772; GO:0021846; GO:0021987; GO:0030155; GO:0030165; GO:0030334; GO:0030496; GO:0031146; GO:0031641; GO:0032147; GO:0032467; GO:0032487; GO:0033624; GO:0034446; GO:0043066; GO:0043161; GO:0043523; GO:0043524; GO:0045184; GO:0051233; GO:0051301; GO:1903429; GO:2000045
GN006969	GN006969.1	Q64521	60.8	701	743	727	5.51e-298	835	GPDM_MOUSE	Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) (Protein TISP38)	Mus musculus (Mouse)	camera-type eye development [GO:0043010]; gluconeogenesis [GO:0006094]; glycerol catabolic process [GO:0019563]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerol-3-phosphate shuttle [GO:0006127]; multicellular organism growth [GO:0035264]	calcium ion binding [GO:0005509]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0004368; GO:0005509; GO:0005739; GO:0005743; GO:0006072; GO:0006094; GO:0006127; GO:0019563; GO:0035264; GO:0043010
GN006970	GN006970.1	Q8K3W3	46.7	120	1141	698	8.31e-22	105	CASC3_MOUSE	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node gene 51 protein homolog) (MLN 51 homolog) (Protein barentsz) (Btz) (mBtz)	Mus musculus (Mouse)	intracellular mRNA localization [GO:0008298]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of RNA helicase activity [GO:1902280]	DEAD/H-box RNA helicase binding [GO:0017151]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; post-spliceosomal complex [GO:0071020]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000398; GO:0003729; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006406; GO:0008298; GO:0010494; GO:0016607; GO:0017151; GO:0019899; GO:0030425; GO:0031625; GO:0031965; GO:0035145; GO:0042802; GO:0048471; GO:0071006; GO:0071007; GO:0071020; GO:1902280; GO:1990904; GO:2000622
GN006973	GN006973.1	P10881	37.4	329	403	404	3.46e-66	219	LA_BOVIN	Lupus La protein homolog (La autoantigen homolog) (La ribonucleoprotein)	Bos taurus (Bovine)	positive regulation of translation [GO:0045727]; tRNA processing [GO:0008033]	mRNA binding [GO:0003729]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0003729; GO:0005634; GO:0005829; GO:0008033; GO:0010494; GO:0045727; GO:1990904
GN006976	GN006976.1	Q9BY79	31.4	156	263	579	5.86e-10	62.8	MFRP_HUMAN	Membrane frizzled-related protein (Membrane-type frizzled-related protein)	Homo sapiens (Human)	embryo development ending in birth or egg hatching [GO:0009792]		apical plasma membrane [GO:0016324]; membrane [GO:0016020]	GO:0009792; GO:0016020; GO:0016324
GN006977	GN006977.1	A7RR34	56.7	90	235	169	4.16e-32	118	FLTOP_NEMVE	Protein Flattop homolog (Cilia- and flagella-associated protein 126)	Nematostella vectensis (Starlet sea anemone)	cilium organization [GO:0044782]		apical plasma membrane [GO:0016324]; ciliary basal body [GO:0036064]; cilium [GO:0005929]	GO:0005929; GO:0016324; GO:0036064; GO:0044782
GN006978	GN006978.1	Q6DGL7	62.4	221	230	225	3.36e-97	285	TM147_DANRE	BOS complex subunit TMEM147 (Transmembrane protein 147)	Danio rerio (Zebrafish) (Brachydanio rerio)	multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; protein localization to nuclear inner membrane [GO:0036228]	ribosome binding [GO:0043022]	endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0005789; GO:0005886; GO:0031965; GO:0036228; GO:0043022; GO:0160063
GN006983	GN006983.1	E8XYF5	32.4	216	210	263	5.11e-14	72.0	TATD_RAHSY	3'-5' ssDNA/RNA exonuclease TatD (EC 3.1.11.-) (EC 3.1.13.-) (DNase TatD)	Rahnella sp. (strain Y9602)	DNA metabolic process [GO:0006259]	3'-5'-RNA exonuclease activity [GO:0000175]; magnesium ion binding [GO:0000287]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]	cytoplasm [GO:0005737]	GO:0000175; GO:0000287; GO:0005737; GO:0006259; GO:0008310
GN006991	GN006991.1	O57460	34.3	99	284	1022	4.06e-09	60.8	TLL1_DANRE	Dorsal-ventral patterning tolloid-like protein 1 (EC 3.4.24.-) (Mini fin protein)	Danio rerio (Zebrafish) (Brachydanio rerio)	blood vessel development [GO:0001568]; determination of ventral identity [GO:0048264]; dorsal/ventral pattern formation [GO:0009953]; embryonic caudal fin morphogenesis [GO:0035124]; embryonic hemopoiesis [GO:0035162]; endothelial cell development [GO:0001885]; mesoderm formation [GO:0001707]; positive regulation of BMP signaling pathway [GO:0030513]; post-anal tail morphogenesis [GO:0036342]; protein processing [GO:0016485]; proteolysis [GO:0006508]	calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0001568; GO:0001707; GO:0001885; GO:0004222; GO:0005509; GO:0005576; GO:0006508; GO:0008233; GO:0008237; GO:0008270; GO:0009953; GO:0016485; GO:0030513; GO:0035124; GO:0035162; GO:0036342; GO:0048264
GN006992	GN006992.1	Q91WJ8	46.6	522	714	651	2.42e-108	346	FUBP1_MOUSE	Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1)	Mus musculus (Mouse)	hematopoietic stem cell proliferation [GO:0071425]; positive regulation of gene expression [GO:0010628]; positive regulation of Schwann cell migration [GO:1900149]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell division [GO:0048103]	mRNA 3'-UTR binding [GO:0003730]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]	GO:0000978; GO:0003730; GO:0005634; GO:0005654; GO:0006357; GO:0010628; GO:0045202; GO:0048103; GO:0071425; GO:1900149
GN006993	GN006993.1	Q76KB1	61.3	284	326	356	1.46e-132	384	HS2ST_CHICK	Heparan sulfate 2-O-sulfotransferase 1 (EC 2.8.2.-) (2-O-sulfotransferase) (2-OST) (2OST) (HS 2-O-sulfotransferase) (cHS2ST) (Heparan sulfate 2-sulfotransferase)	Gallus gallus (Chicken)	heparan sulfate proteoglycan biosynthetic process [GO:0015012]	heparan sulfate 2-sulfotransferase activity [GO:0004394]; identical protein binding [GO:0042802]	Golgi membrane [GO:0000139]	GO:0000139; GO:0004394; GO:0015012; GO:0042802
GN006995	GN006995.1	A2AGA4	38.5	257	379	302	8.07e-52	177	RHBL2_MOUSE	Rhomboid-related protein 2 (RRP2) (EC 3.4.21.105) [Cleaved into: Rhomboid-related protein 2, N-terminal fragment (NTF); Rhomboid-related protein 2, C-terminal fragment (CTF)]	Mus musculus (Mouse)		serine-type endopeptidase activity [GO:0004252]	plasma membrane [GO:0005886]	GO:0004252; GO:0005886
GN006996	GN006996.1	Q5ZJK0	51.5	555	649	584	3.90e-165	488	RGPS1_CHICK	Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (RalA exchange factor RalGPS1)	Gallus gallus (Chicken)	regulation of Ral protein signal transduction [GO:0032485]; small GTPase-mediated signal transduction [GO:0007264]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005085; GO:0005737; GO:0005886; GO:0007264; GO:0032485
GN006998	GN006998.1	Q9VMY1	43.0	158	156	247	7.15e-32	117	RM24_DROME	Large ribosomal subunit protein uL24m (39S ribosomal protein L24, mitochondrial) (L24mt) (MRP-L24)	Drosophila melanogaster (Fruit fly)	mitochondrial translation [GO:0032543]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003723; GO:0003735; GO:0005739; GO:0005762; GO:0032543
GN006999	GN006999.1	Q6ZFH6	28.6	262	281	533	2.17e-24	105	RCN11_ORYSJ	Beta-1,2-xylosyltransferase RCN11 (OsXylT) (EC 2.4.2.-) (Protein REDUCED CULM NUMBER 11)	Oryza sativa subsp. japonica (Rice)	shoot system development [GO:0048367]	UDP-xylosyltransferase activity [GO:0035252]	Golgi membrane [GO:0000139]	GO:0000139; GO:0035252; GO:0048367
GN007002	GN007002.1	Q6ZFH6	26.5	260	339	533	9.47e-22	99.4	RCN11_ORYSJ	Beta-1,2-xylosyltransferase RCN11 (OsXylT) (EC 2.4.2.-) (Protein REDUCED CULM NUMBER 11)	Oryza sativa subsp. japonica (Rice)	shoot system development [GO:0048367]	UDP-xylosyltransferase activity [GO:0035252]	Golgi membrane [GO:0000139]	GO:0000139; GO:0035252; GO:0048367
GN007007	GN007007.1	Q8CDF7	32.8	195	413	570	1.15e-12	73.2	EXD1_MOUSE	piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (mExd1)	Mus musculus (Mouse)	piRNA processing [GO:0034587]; regulatory ncRNA-mediated gene silencing [GO:0031047]	protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; P granule [GO:0043186]; PET complex [GO:1990923]	GO:0003723; GO:0005737; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:1990923
GN007008	GN007008.1	H9IUR0	31.7	104	451	315	6.01e-09	60.8	EXD1_BOMMO	piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (BmExd1)	Bombyx mori (Silk moth)	piRNA processing [GO:0034587]; regulatory ncRNA-mediated gene silencing [GO:0031047]	protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; P granule [GO:0043186]; PET complex [GO:1990923]	GO:0003723; GO:0005737; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:1990923
GN007010	GN007010.1	Q6PCJ9	50.2	221	256	296	9.28e-76	234	PPT2A_XENLA	Lysosomal thioesterase PPT2-A (PPT-2-A) (EC 3.1.2.2)	Xenopus laevis (African clawed frog)		fatty acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; palmitoyl hydrolase activity [GO:0098599]; thiolester hydrolase activity [GO:0016790]	extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0005576; GO:0005764; GO:0016790; GO:0047617; GO:0052816; GO:0098599
GN007011	GN007011.1	F1NV61	29.4	235	294	309	6.95e-16	79.7	CASP7_CHICK	Caspase-7 (CASP-7) (EC 3.4.22.60) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]	Gallus gallus (Chicken)	apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; execution phase of apoptosis [GO:0097194]; lymphocyte apoptotic process [GO:0070227]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of plasma membrane repair [GO:1905686]; proteolysis [GO:0006508]	aspartic-type endopeptidase activity [GO:0004190]; cysteine-type endopeptidase activity [GO:0004197]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0003723; GO:0004190; GO:0004197; GO:0005576; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0042742; GO:0043525; GO:0070227; GO:0097194; GO:1905686
GN007015	GN007015.1	Q95M17	36.8	272	460	472	5.19e-57	198	CHIA_BOVIN	Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Chitin-binding protein b04) (CBPb04)	Bos taurus (Bovine)	carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; positive regulation of chemokine production [GO:0032722]; production of molecular mediator involved in inflammatory response [GO:0002532]	chitin binding [GO:0008061]; chitinase activity [GO:0004568]; endochitinase activity [GO:0008843]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	GO:0002532; GO:0004568; GO:0005576; GO:0005737; GO:0005975; GO:0006032; GO:0008061; GO:0008843; GO:0032722
GN007016	GN007016.1	Q9UBQ7	59.2	319	320	328	7.49e-127	368	GRHPR_HUMAN	Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81)	Homo sapiens (Human)	dicarboxylic acid metabolic process [GO:0043648]; glyoxylate metabolic process [GO:0046487]	carboxylic acid binding [GO:0031406]; glyoxylate reductase (NADPH) activity [GO:0030267]; hydroxypyruvate reductase (NADH) activity [GO:0008465]; hydroxypyruvate reductase (NADPH) activity [GO:0120509]; hydroxypyruvate reductase [NAD(P)H] activity [GO:0016618]; NAD binding [GO:0051287]; NADPH binding [GO:0070402]; protein homodimerization activity [GO:0042803]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]	GO:0005737; GO:0005739; GO:0005782; GO:0005829; GO:0008465; GO:0016618; GO:0030267; GO:0031406; GO:0042803; GO:0043648; GO:0046487; GO:0051287; GO:0070062; GO:0070402; GO:0120509; GO:1902494
GN007017	GN007017.1	Q9VCA8	40.2	97	212	4001	4.85e-11	65.1	ANKHM_DROME	Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein)	Drosophila melanogaster (Fruit fly)	compound eye photoreceptor cell differentiation [GO:0001751]; dorsal appendage formation [GO:0046843]; flight [GO:0060361]; innate immune response [GO:0045087]; negative regulation of establishment of blood-brain barrier [GO:0090212]; negative regulation of type 2 mitophagy [GO:1905090]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of sevenless signaling pathway [GO:0045874]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sarcomere organization [GO:0045214]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; wound healing, spreading of cells [GO:0044319]; wound healing, spreading of epidermal cells [GO:0035313]	protein kinase binding [GO:0019901]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; M band [GO:0031430]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; Z disc [GO:0030018]	GO:0001751; GO:0003723; GO:0005634; GO:0005737; GO:0005829; GO:0019901; GO:0030018; GO:0031430; GO:0035313; GO:0044319; GO:0045087; GO:0045214; GO:0045747; GO:0045874; GO:0045944; GO:0046427; GO:0046843; GO:0048010; GO:0060361; GO:0090212; GO:0090575; GO:1905090
GN007018	GN007018.1	O01393	39.5	377	407	386	2.23e-101	309	UNC9_CAEEL	Innexin unc-9 (Uncoordinated protein 9)	Caenorhabditis elegans	monoatomic ion transmembrane transport [GO:0034220]; positive regulation of locomotion [GO:0040017]	actin filament binding [GO:0051015]; gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	cell-cell junction [GO:0005911]; gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0034220; GO:0040017; GO:0051015; GO:0055077
GN007024	GN007024.1	Q9NZJ4	25.7	4705	4481	4579	0.0	1141	SACS_HUMAN	Sacsin (DnaJ homolog subfamily C member 29)	Homo sapiens (Human)	negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0070852; GO:0090084
GN007025	GN007025.1	Q9NZJ4	24.6	2385	2041	4579	2.72e-143	502	SACS_HUMAN	Sacsin (DnaJ homolog subfamily C member 29)	Homo sapiens (Human)	negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0070852; GO:0090084
GN007026	GN007026.1	Q9NZJ4	27.0	2110	1968	4579	1.48e-163	563	SACS_HUMAN	Sacsin (DnaJ homolog subfamily C member 29)	Homo sapiens (Human)	negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0070852; GO:0090084
GN007030	GN007030.1	Q9BX70	27.7	452	450	525	1.09e-40	155	BTBD2_HUMAN	BTB/POZ domain-containing protein 2	Homo sapiens (Human)	neurogenesis [GO:0022008]		cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; P-body [GO:0000932]	GO:0000932; GO:0005737; GO:0005829; GO:0022008; GO:0036464
GN007032	GN007032.1	Q21920	25.2	322	456	2620	2.95e-10	66.6	ANKHM_CAEEL	Ankyrin repeat and KH domain-containing protein mask-1 (Multiple ankyrin repeats single KH domain homolog)	Caenorhabditis elegans		RNA binding [GO:0003723]	cytoplasm [GO:0005737]	GO:0003723; GO:0005737
GN007033	GN007033.1	Q9TU53	36.4	110	253	3620	8.91e-10	62.4	CUBN_CANLF	Cubilin	Canis lupus familiaris (Dog) (Canis familiaris)		calcium ion binding [GO:0005509]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; endosome [GO:0005768]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0005509; GO:0005765; GO:0005768; GO:0005886; GO:0016324; GO:0031526; GO:0043235
GN007034	GN007034.1	Q9UHJ9	50.2	235	256	254	1.72e-71	222	PGAP2_HUMAN	Acyltransferase PGAP2 (EC 2.3.-.-) (FGF receptor-activating protein 1) (Post-GPI attachment to proteins factor 2)	Homo sapiens (Human)	GPI anchor biosynthetic process [GO:0006506]; GPI anchor remodelling [GO:0120574]		endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0005789; GO:0006506; GO:0016020; GO:0120574
GN007035	GN007035.1	Q8K0U4	36.0	630	581	675	1.72e-115	361	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007036	GN007036.1	Q8NEN9	27.7	1080	1161	1154	1.09e-82	297	PDZD8_HUMAN	PDZ domain-containing protein 8 (Lysosomal vacuolator) (LYVAC) (Sarcoma antigen NY-SAR-84/NY-SAR-104)	Homo sapiens (Human)	lipophagy [GO:0061724]; lysosome organization [GO:0007040]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrion-endoplasmic reticulum membrane tethering [GO:1990456]; neuron projection development [GO:0031175]; organelle localization by membrane tethering [GO:0140056]; response to osmotic stress [GO:0006970]	endoplasmic reticulum-endosome tether activity [GO:0170016]; endoplasmic reticulum-organelle membrane tether activity [GO:0170009]; lipid binding [GO:0008289]; lipid transfer activity [GO:0120013]; mitochondrion-endoplasmic reticulum membrane tether activity [GO:0140474]; molecular condensate scaffold activity [GO:0140693]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; endoplasmic reticulum-lysosome membrane contact site [GO:7770052]; membrane [GO:0016020]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrion [GO:0005739]	GO:0005739; GO:0005789; GO:0006970; GO:0007040; GO:0008289; GO:0016020; GO:0031175; GO:0044233; GO:0051560; GO:0061724; GO:0120013; GO:0140056; GO:0140284; GO:0140474; GO:0140693; GO:0170009; GO:0170016; GO:1990456; GO:7770052
GN007038	GN007038.1	Q9R0Y1	34.6	81	126	495	2.28e-13	68.6	ASIC5_MOUSE	Bile acid-sensitive ion channel (BASIC) (Acid-sensing ion channel subunit family member 5) (Amiloride-sensitive cation channel 5) (Brain-liver-intestine amiloride-sensitive Na(+) channel) (BLINaC)	Mus musculus (Mouse)	neuronal action potential [GO:0019228]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]	bile acid-gated sodium channel activity [GO:0160228]; ligand-gated sodium channel activity [GO:0015280]; proton channel activity [GO:0015252]; sodium channel activity [GO:0005272]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005272; GO:0005886; GO:0015252; GO:0015280; GO:0016020; GO:0016324; GO:0019228; GO:0035725; GO:0098719; GO:0160228
GN007041	GN007041.1	Q9H3E2	38.5	852	946	840	2.93e-187	564	SNX25_HUMAN	Sorting nexin-25	Homo sapiens (Human)	negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; receptor catabolic process [GO:0032801]	phosphatidylinositol binding [GO:0035091]	endosome [GO:0005768]; endosome membrane [GO:0010008]	GO:0005768; GO:0010008; GO:0030512; GO:0032801; GO:0035091
GN007042	GN007042.1	P42519	27.6	283	273	597	2.12e-17	85.1	STAR_DROME	Protein Star	Drosophila melanogaster (Fruit fly)	behavioral response to ethanol [GO:0048149]; compound eye photoreceptor cell differentiation [GO:0001751]; compound eye retinal cell programmed cell death [GO:0046667]; determination of dorsal identity [GO:0048263]; determination of genital disc primordium [GO:0035225]; dorsal appendage formation [GO:0046843]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endosomal transport [GO:0016197]; epidermal growth factor receptor ligand maturation [GO:0038004]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; ommatidial rotation [GO:0016318]; photoreceptor cell fate determination [GO:0043703]; positive regulation of protein secretion [GO:0050714]; regulation of circadian sleep/wake cycle [GO:0042749]; stem cell fate commitment [GO:0048865]; stomatogastric nervous system development [GO:0007421]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]	GO:0000139; GO:0001751; GO:0005783; GO:0005789; GO:0005794; GO:0005886; GO:0006888; GO:0007421; GO:0007474; GO:0007476; GO:0016197; GO:0016318; GO:0031902; GO:0035225; GO:0038004; GO:0042749; GO:0043703; GO:0046667; GO:0046843; GO:0048149; GO:0048263; GO:0048865; GO:0050714; GO:0061331; GO:0097038
GN007044	GN007044.1	Q26481	79.5	288	301	295	6.28e-165	462	RL5_STYCL	Large ribosomal subunit protein uL18 (60S ribosomal protein L5)	Styela clava (Sea squirt)	ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]	5S rRNA binding [GO:0008097]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]; nucleus [GO:0005634]	GO:0000027; GO:0003735; GO:0005634; GO:0005737; GO:0006412; GO:0008097; GO:0022625
GN007045	GN007045.1	Q5T9S5	27.2	791	1584	1454	4.69e-29	130	CCD18_HUMAN	Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24)	Homo sapiens (Human)	positive regulation of adipose tissue development [GO:1904179]		centriolar satellite [GO:0034451]	GO:0034451; GO:1904179
GN007046	GN007046.1	A0A2B4RNI3	27.0	163	666	688	2.97e-15	83.2	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN007047	GN007047.1	A0A2B4RNI3	25.5	251	632	688	5.01e-16	85.5	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN007054	GN007054.1	Q9W0E8	36.0	808	763	793	3.72e-146	450	ZER1_DROME	Protein zer-1 homolog (Zyg-11 homolog B-like protein)	Drosophila melanogaster (Fruit fly)	macroautophagy [GO:0016236]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]	GO:0016236; GO:0031462; GO:0043161; GO:1990756
GN007057	GN007057.1	Q8K0U4	31.1	624	610	675	1.89e-80	270	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007058	GN007058.1	Q96MM6	31.6	668	624	686	1.28e-88	292	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN007059	GN007059.1	Q8K0U4	30.6	526	488	675	3.24e-63	220	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007060	GN007060.1	Q9CZJ2	36.5	189	222	685	2.90e-26	109	HS12B_MOUSE	Heat shock 70 kDa protein 12B	Mus musculus (Mouse)	angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]			GO:0001525; GO:0043542
GN007068	GN007068.1	P46023	35.2	193	193	1115	2.00e-31	123	GR101_LYMST	G protein-coupled receptor GRL101	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; hormone-mediated signaling pathway [GO:0009755]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007189; GO:0008528; GO:0009755
GN007072	GN007072.1	Q8N2E2	22.9	821	1023	1590	2.25e-27	124	VWDE_HUMAN	von Willebrand factor D and EGF domain-containing protein	Homo sapiens (Human)		signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]	GO:0005102; GO:0005576; GO:0009986
GN007073	GN007073.1	Q9BQA5	46.0	396	652	517	3.66e-121	373	HINFP_HUMAN	Histone H4 transcription factor (Histone nuclear factor P) (HiNF-P) (MBD2-interacting zinc finger protein) (Methyl-CpG-binding protein 2-interacting zinc finger protein)	Homo sapiens (Human)	cell cycle G1/S phase transition [GO:0044843]; DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; DNA-templated transcription [GO:0006351]; establishment of protein localization [GO:0045184]; G1/S transition of mitotic cell cycle [GO:0000082]; in utero embryonic development [GO:0001701]; myoblast differentiation [GO:0045445]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	Cajal body [GO:0015030]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000077; GO:0000082; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0001228; GO:0001701; GO:0003677; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0006281; GO:0006351; GO:0006355; GO:0006357; GO:0010628; GO:0010629; GO:0015030; GO:0019899; GO:0042393; GO:0044843; GO:0045184; GO:0045445; GO:0045892; GO:0045893; GO:0045944
GN007074	GN007074.1	Q3TYE7	50.3	155	229	245	1.72e-48	162	TLCD5_MOUSE	TLC domain-containing protein 5 (Transmembrane protein 136)	Mus musculus (Mouse)			membrane [GO:0016020]	GO:0016020
GN007080	GN007080.1	P83298	41.7	242	296	242	4.75e-57	186	FIBC_LUMRU	Fibrinolytic enzyme, isozyme C (F-II) (EC 3.4.21.-)	Lumbricus rubellus (Humus earthworm)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]		GO:0004252; GO:0006508
GN007081	GN007081.1	P83298	41.7	242	296	242	4.75e-57	186	FIBC_LUMRU	Fibrinolytic enzyme, isozyme C (F-II) (EC 3.4.21.-)	Lumbricus rubellus (Humus earthworm)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]		GO:0004252; GO:0006508
GN007082	GN007082.1	P83298	41.7	242	281	242	4.16e-57	186	FIBC_LUMRU	Fibrinolytic enzyme, isozyme C (F-II) (EC 3.4.21.-)	Lumbricus rubellus (Humus earthworm)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]		GO:0004252; GO:0006508
GN007084	GN007084.1	P35003	40.2	241	288	254	4.03e-47	161	CTRL_HALRU	Chymotrypsin-like serine proteinase (EC 3.4.21.-)	Haliotis rufescens (California red abalone)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]	GO:0004252; GO:0005576; GO:0006508
GN007085	GN007085.1	O88854	29.6	338	392	371	8.03e-37	140	GALR2_MOUSE	Galanin receptor type 2 (GAL2-R) (GALR-2)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; galanin-activated signaling pathway [GO:0090663]; inositol phosphate metabolic process [GO:0043647]; neuron projection development [GO:0031175]; phosphatidylinositol metabolic process [GO:0046488]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transcription by RNA polymerase II [GO:0045944]	galanin receptor activity [GO:0004966]; neuropeptide binding [GO:0042923]; peptide hormone binding [GO:0017046]	9+0 non-motile cilium [GO:0097731]; cilium [GO:0005929]; plasma membrane [GO:0005886]	GO:0004966; GO:0005886; GO:0005929; GO:0007186; GO:0007189; GO:0007200; GO:0007204; GO:0017046; GO:0031175; GO:0042923; GO:0043647; GO:0045944; GO:0046488; GO:0090663; GO:0097731
GN007088	GN007088.1	P23347	44.8	1064	1395	1234	3.93e-272	812	B3A2_RAT	Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Band 3-related protein 2) (B3RP-2) (Non-erythroid band 3-like protein) (Solute carrier family 4 member 2)	Rattus norvegicus (Rat)	amelogenesis [GO:0097186]; bicarbonate transport [GO:0015701]; chloride transport [GO:0006821]; digestive tract development [GO:0048565]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000565]; osteoclast differentiation [GO:0030316]; positive regulation of enamel mineralization [GO:0070175]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of bone resorption [GO:0045124]; regulation of intracellular pH [GO:0051453]; spermatogenesis [GO:0007283]	chloride transmembrane transporter activity [GO:0015108]; chloride:bicarbonate antiporter activity [GO:0140900]; enzyme binding [GO:0019899]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0006821; GO:0007283; GO:0015108; GO:0015701; GO:0016020; GO:0016323; GO:0016324; GO:0019899; GO:0030316; GO:0032956; GO:0043377; GO:0045124; GO:0048565; GO:0051453; GO:0070175; GO:0097186; GO:0140900; GO:2000565
GN007089	GN007089.1	O01393	39.2	378	428	386	6.45e-98	301	UNC9_CAEEL	Innexin unc-9 (Uncoordinated protein 9)	Caenorhabditis elegans	monoatomic ion transmembrane transport [GO:0034220]; positive regulation of locomotion [GO:0040017]	actin filament binding [GO:0051015]; gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	cell-cell junction [GO:0005911]; gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0034220; GO:0040017; GO:0051015; GO:0055077
GN007090	GN007090.1	O46385	40.7	1123	4261	2194	1.82e-235	786	SVIL_BOVIN	Supervillin (Archvillin) (p205/p250)	Bos taurus (Bovine)	actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; positive regulation of cytokinesis [GO:0032467]	actin filament binding [GO:0051015]; molecular adaptor activity [GO:0060090]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cleavage furrow [GO:0032154]; microtubule minus-end [GO:0036449]; midbody [GO:0030496]; podosome [GO:0002102]	GO:0002102; GO:0005546; GO:0008154; GO:0030496; GO:0032154; GO:0032467; GO:0036449; GO:0051014; GO:0051015; GO:0051016; GO:0060090
GN007092	GN007092.1	P41340	93.1	376	376	376	2.67e-267	728	ACT3_LIMPO	Actin-3 (EC 3.6.4.-)	Limulus polyphemus (Atlantic horseshoe crab)	anatomical structure formation involved in morphogenesis [GO:0048646]; cell development [GO:0048468]	ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887; GO:0048468; GO:0048646
GN007093	GN007093.1	P41340	92.6	376	376	376	3.11e-266	725	ACT3_LIMPO	Actin-3 (EC 3.6.4.-)	Limulus polyphemus (Atlantic horseshoe crab)	anatomical structure formation involved in morphogenesis [GO:0048646]; cell development [GO:0048468]	ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887; GO:0048468; GO:0048646
GN007094	GN007094.1	P41340	92.8	376	376	376	3.79e-267	728	ACT3_LIMPO	Actin-3 (EC 3.6.4.-)	Limulus polyphemus (Atlantic horseshoe crab)	anatomical structure formation involved in morphogenesis [GO:0048646]; cell development [GO:0048468]	ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887; GO:0048468; GO:0048646
GN007098	GN007098.1	P38606	84.7	613	636	617	0.0	1057	VATA_HUMAN	V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)	Homo sapiens (Human)	ATP metabolic process [GO:0046034]; cellular response to amino acid stimulus [GO:0071230]; cellular response to increased oxygen levels [GO:0036295]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular iron ion homeostasis [GO:0006879]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; positive regulation of TORC1 signaling [GO:1904263]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical plasma membrane [GO:0016324]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosomal proton-transporting V-type ATPase complex [GO:0046611]; lysosome [GO:0005764]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase complex [GO:0033176]; secretory granule [GO:0030141]; transport vesicle [GO:0030133]; vacuolar membrane [GO:0005774]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	GO:0000139; GO:0000221; GO:0005524; GO:0005737; GO:0005764; GO:0005765; GO:0005774; GO:0005829; GO:0005886; GO:0005902; GO:0006879; GO:0007035; GO:0007042; GO:0010008; GO:0016020; GO:0016241; GO:0016324; GO:0016469; GO:0016887; GO:0030133; GO:0030141; GO:0030665; GO:0033176; GO:0036295; GO:0046034; GO:0046611; GO:0046961; GO:0048388; GO:0051452; GO:0061795; GO:0070062; GO:0071230; GO:0097401; GO:0098793; GO:1902600; GO:1904263
GN007099	GN007099.1	Q0P4J9	29.2	212	235	308	1.29e-28	112	SR5A3_XENTR	Polyprenal reductase (EC 1.3.1.94) (3-oxo-5-alpha-steroid 4-dehydrogenase 3) (EC 1.3.1.22) (Steroid 5-alpha-reductase 3) (S5AR 3) (SR type 3)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; dolichyl monophosphate biosynthetic process [GO:0043048]	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity [GO:0047751]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; polyprenal reductase activity [GO:0160198]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0006488; GO:0016628; GO:0043048; GO:0047751; GO:0160198
GN007104	GN007104.1	P31400	68.7	578	578	617	9.55e-282	783	VATA_MANSE	V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar proton pump subunit alpha)	Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)	ATP metabolic process [GO:0046034]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	lysosomal membrane [GO:0005765]; proton-transporting V-type ATPase, V1 domain [GO:0033180]	GO:0005524; GO:0005765; GO:0016887; GO:0033180; GO:0046034; GO:0046961
GN007105	GN007105.1	Q9Y4A0	25.5	377	836	524	3.10e-11	70.5	JERKL_HUMAN	Jerky protein homolog-like (Human homolog of mouse jerky gene protein) (HHMJG)	Homo sapiens (Human)	central nervous system development [GO:0007417]	DNA binding [GO:0003677]	nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0007417
GN007109	GN007109.1	Q6V0K7	40.0	95	321	546	8.59e-17	84.3	OIT3_RAT	Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein)	Rattus norvegicus (Rat)	renal system process [GO:0003014]	calcium ion binding [GO:0005509]	cell surface [GO:0009986]; nuclear envelope [GO:0005635]	GO:0003014; GO:0005509; GO:0005635; GO:0009986
GN007111	GN007111.1	O15213	47.4	521	603	610	1.18e-155	463	WDR46_HUMAN	WD repeat-containing protein 46 (WD repeat-containing protein BING4)	Homo sapiens (Human)	maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	GO:0000462; GO:0003723; GO:0005654; GO:0005730; GO:0030490; GO:0032040; GO:0042274
GN007113	GN007113.1	A2AVA0	26.7	273	547	3567	4.79e-21	101	SVEP1_MOUSE	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)	Mus musculus (Mouse)	cell migration [GO:0016477]; epidermis development [GO:0008544]; epithelial cell-cell adhesion [GO:0090136]; gene expression [GO:0010467]; lymph circulation [GO:0003017]; lymph vessel development [GO:0001945]; lymph vessel morphogenesis [GO:0036303]; negative regulation of vasoconstriction [GO:0045906]; positive regulation of platelet activation [GO:0010572]; Tie signaling pathway [GO:0048014]; tight junction organization [GO:0120193]	calcium ion binding [GO:0005509]; chromatin binding [GO:0003682]; integrin binding [GO:0005178]; integrin binding involved in cell-matrix adhesion [GO:0098640]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0001945; GO:0003017; GO:0003682; GO:0005178; GO:0005509; GO:0005576; GO:0005634; GO:0005737; GO:0008544; GO:0010467; GO:0010572; GO:0016020; GO:0016477; GO:0031012; GO:0036303; GO:0045906; GO:0048014; GO:0090136; GO:0098640; GO:0120193
GN007114	GN007114.1	Q93T20	29.4	177	221	186	7.01e-11	62.4	CHRR_PSEPU	Quinone reductase (EC 1.6.5.2) (Chromate reductase) (CHRR) (EC 1.6.-.-) (NAD(P)H dehydrogenase (quinone))	Pseudomonas putida (Arthrobacter siderocapsulatus)		FMN binding [GO:0010181]; NADH dehydrogenase (quinone) (non-electrogenic) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]	cytosol [GO:0005829]	GO:0005829; GO:0008753; GO:0010181; GO:0050136
GN007115	GN007115.1	R9UTQ8	27.6	250	297	268	1.11e-21	95.1	PROHY_STRGD	L-proline trans-4-hydroxylase (P4H) (EC 1.14.11.57)	Streptomyces griseoviridis	antibiotic metabolic process [GO:0016999]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506]		GO:0005506; GO:0016706; GO:0016999
GN007122	GN007122.1	Q0V8F1	42.5	961	978	915	5.59e-251	732	CORO7_BOVIN	Coronin-7 (Crn7)	Bos taurus (Bovine)	actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; cell migration [GO:0016477]; Golgi to endosome transport [GO:0006895]; positive regulation of hippo signaling [GO:0035332]	actin binding [GO:0003779]; actin filament binding [GO:0051015]	actin filament [GO:0005884]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0003779; GO:0005802; GO:0005829; GO:0005884; GO:0005886; GO:0006895; GO:0007015; GO:0016477; GO:0030041; GO:0031410; GO:0035332; GO:0051015
GN007123	GN007123.1	Q27237	54.1	394	527	520	1.03e-143	426	DJTID_DROME	DnaJ homolog l(2)tid, mitochondrial (Protein lethal(2)tumorous imaginal discs) (TID50) (TID56)	Drosophila melanogaster (Fruit fly)	mitochondrion organization [GO:0007005]; negative regulation of smoothened signaling pathway [GO:0045879]; protein folding [GO:0006457]; response to heat [GO:0009408]	ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; patched binding [GO:0005113]	cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0005113; GO:0005524; GO:0005739; GO:0005741; GO:0005829; GO:0006457; GO:0007005; GO:0009408; GO:0031072; GO:0045879
GN007125	GN007125.1	Q7TN73	46.1	594	676	797	1.27e-177	528	CASD1_MOUSE	N-acetylneuraminate (7)9-O-acetyltransferase (EC 2.3.1.45) (CAS1 domain-containing protein 1) (CAS1 protein) (Cas1p) (Sialate O-acetyltransferase) (SOAT)	Mus musculus (Mouse)	carbohydrate metabolic process [GO:0005975]	N-acetylneuraminate 9-O-acetyltransferase activity [GO:0047186]	Golgi membrane [GO:0000139]	GO:0000139; GO:0005975; GO:0047186
GN007127	GN007127.1	Q7Z6M4	28.3	283	329	381	9.82e-17	83.6	MTEF4_HUMAN	Transcription termination factor 4, mitochondrial (Mitochondrial transcription termination factor 4) (mTERF domain-containing protein 2) [Cleaved into: mTERF domain-containing protein 2 processed]	Homo sapiens (Human)	mitochondrial large ribosomal subunit assembly [GO:1902775]; mitochondrial ribosome assembly [GO:0061668]; rRNA processing [GO:0006364]	protein-RNA adaptor activity [GO:0140517]; RNA folding chaperone [GO:0140691]; rRNA binding [GO:0019843]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0006364; GO:0019843; GO:0061668; GO:0140517; GO:0140691; GO:1902775
GN007128	GN007128.1	Q86Z23	40.6	106	183	238	1.97e-14	72.0	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN007129	GN007129.1	Q86Z23	40.2	127	130	238	2.18e-16	75.5	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN007131	GN007131.1	P47823	38.6	682	682	721	7.43e-155	468	EI2BE_RABIT	Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon)	Oryctolagus cuniculus (Rabbit)	astrocyte development [GO:0014002]; astrocyte differentiation [GO:0048708]; cytoplasmic translational initiation [GO:0002183]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; positive regulation of translational initiation [GO:0045948]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]	GO:0001541; GO:0002183; GO:0003743; GO:0005085; GO:0005737; GO:0005829; GO:0005851; GO:0006413; GO:0009408; GO:0009749; GO:0014002; GO:0014003; GO:0031369; GO:0034976; GO:0042552; GO:0043434; GO:0045948; GO:0048708; GO:0050852
GN007132	GN007132.1	O02373	67.4	475	496	476	1.53e-236	659	UGDH_DROME	UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (Protein sugarless) (Protein suppenkasper)	Drosophila melanogaster (Fruit fly)	chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; epithelial cell migration, open tracheal system [GO:0007427]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; mesoderm migration involved in gastrulation [GO:0007509]; segment polarity determination [GO:0007367]; UDP-glucuronate biosynthetic process [GO:0006065]	NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003979; GO:0005634; GO:0005737; GO:0005829; GO:0006024; GO:0006065; GO:0007367; GO:0007427; GO:0007509; GO:0008543; GO:0015012; GO:0050650; GO:0051287
GN007135	GN007135.1	O35867	30.4	911	1734	1095	6.64e-71	264	NEB1_RAT	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (PP1bp175) (Protein phosphatase 1 regulatory subunit 9A) (p180)	Rattus norvegicus (Rat)	actin filament organization [GO:0007015]; calcium-mediated signaling [GO:0019722]; cellular response to toxic substance [GO:0097237]; excitatory postsynaptic potential [GO:0060079]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of spontaneous neurotransmitter secretion [GO:1904049]; negative regulation of stress fiber assembly [GO:0051497]; neuron development [GO:0048666]; neuron projection development [GO:0031175]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of long-term synaptic depression [GO:1900454]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein kinase activity [GO:0045860]; postsynaptic actin cytoskeleton organization [GO:0098974]; regulation of actin filament polymerization [GO:0030833]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of filopodium assembly [GO:0051489]; regulation of synapse assembly [GO:0051963]; regulation of synapse structural plasticity [GO:0051823]	actin filament binding [GO:0051015]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein phosphatase 1 binding [GO:0008157]; protein-containing complex binding [GO:0044877]; transmembrane transporter binding [GO:0044325]	actin cytoskeleton [GO:0015629]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; dendritic spine neck [GO:0044326]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; growth cone lamellipodium [GO:1990761]; lamellipodium [GO:0030027]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; postsynaptic actin cytoskeleton [GO:0098871]; postsynaptic density [GO:0014069]	GO:0005737; GO:0005856; GO:0007015; GO:0008157; GO:0010976; GO:0014069; GO:0015629; GO:0019722; GO:0019901; GO:0019904; GO:0030027; GO:0030175; GO:0030425; GO:0030426; GO:0030833; GO:0030864; GO:0031175; GO:0031594; GO:0042802; GO:0043025; GO:0043197; GO:0044325; GO:0044326; GO:0044877; GO:0045860; GO:0048666; GO:0050804; GO:0051015; GO:0051020; GO:0051489; GO:0051497; GO:0051823; GO:0051963; GO:0060079; GO:0060999; GO:0061001; GO:0097237; GO:0098871; GO:0098974; GO:0098978; GO:1900272; GO:1900454; GO:1904049; GO:1990761
GN007136	GN007136.1	Q6NZR5	51.9	1251	1229	1244	0.0	1172	SKI2_MOUSE	Superkiller complex protein 2 (Ski2) (EC 3.6.4.13)	Mus musculus (Mouse)	nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; nuclear-transcribed mRNA catabolic process, non-stop decay [GO:0070481]; rescue of stalled cytosolic ribosome [GO:0072344]	3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; Ski complex [GO:0055087]	GO:0000956; GO:0003723; GO:0005524; GO:0005634; GO:0005737; GO:0016887; GO:0034458; GO:0055087; GO:0070478; GO:0070481; GO:0072344
GN007146	GN007146.1	Q9PVV4	28.1	1851	2024	2031	3.99e-84	311	PCM1_XENLA	Pericentriolar material 1 protein (PCM-1) (xPCM-1)	Xenopus laevis (African clawed frog)	cilium assembly [GO:0060271]; intraciliary transport involved in cilium assembly [GO:0035735]; microtubule anchoring at centrosome [GO:0034454]; non-motile cilium assembly [GO:1905515]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539]	identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]	GO:0005737; GO:0005813; GO:0034451; GO:0034454; GO:0035735; GO:0036064; GO:0042802; GO:0060090; GO:0060271; GO:0071539; GO:0090316; GO:1905515
GN007147	GN007147.1	Q8CDF7	30.9	363	947	570	2.24e-40	161	EXD1_MOUSE	piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (mExd1)	Mus musculus (Mouse)	piRNA processing [GO:0034587]; regulatory ncRNA-mediated gene silencing [GO:0031047]	protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; P granule [GO:0043186]; PET complex [GO:1990923]	GO:0003723; GO:0005737; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:1990923
GN007149	GN007149.1	Q0IHV1	26.1	963	1173	1380	8.89e-76	278	INF2_XENTR	Inverted formin-2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	actin cytoskeleton organization [GO:0030036]	actin binding [GO:0003779]; small GTPase binding [GO:0031267]		GO:0003779; GO:0030036; GO:0031267
GN007151	GN007151.1	F7H9X2	43.9	553	806	744	1.54e-143	443	TRIM2_CALJA	Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2)	Callithrix jacchus (White-tufted-ear marmoset) (Simia Jacchus)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0043161; GO:0043523; GO:0061630
GN007152	GN007152.1	Q27J81	32.2	980	991	1249	5.59e-88	310	INF2_HUMAN	Inverted formin-2 (HBEBP2-binding protein C)	Homo sapiens (Human)	actin filament polymerization [GO:0030041]; regulation of mitochondrial fission [GO:0090140]	actin binding [GO:0003779]; small GTPase binding [GO:0031267]	actin filament [GO:0005884]; perinuclear region of cytoplasm [GO:0048471]	GO:0003779; GO:0005884; GO:0030041; GO:0031267; GO:0048471; GO:0090140
GN007153	GN007153.1	Q6NW96	48.1	426	410	439	2.69e-66	220	SP9_DANRE	Transcription factor Sp9	Danio rerio (Zebrafish) (Brachydanio rerio)	embryonic limb morphogenesis [GO:0030326]; embryonic pectoral fin morphogenesis [GO:0035118]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0030326; GO:0035118; GO:0045743
GN007154	GN007154.1	Q6NW96	44.1	345	399	439	4.99e-67	222	SP9_DANRE	Transcription factor Sp9	Danio rerio (Zebrafish) (Brachydanio rerio)	embryonic limb morphogenesis [GO:0030326]; embryonic pectoral fin morphogenesis [GO:0035118]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0030326; GO:0035118; GO:0045743
GN007155	GN007155.1	Q8SWU7	70.6	398	397	397	6.05e-196	549	OLA1_DROME	Obg-like ATPase 1	Drosophila melanogaster (Fruit fly)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; GTP binding [GO:0005525]; ribosomal large subunit binding [GO:0043023]	cytoplasm [GO:0005737]	GO:0005524; GO:0005525; GO:0005737; GO:0016887; GO:0043023
GN007157	GN007157.1	Q0P4P2	53.0	217	217	457	1.37e-75	238	FBCD1_XENTR	Fibrinogen C domain-containing protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			extracellular matrix [GO:0031012]; membrane [GO:0016020]	GO:0016020; GO:0031012
GN007160	GN007160.1	Q08BM0	45.5	132	588	310	7.80e-29	120	TM10B_DANRE	tRNA methyltransferase 10 homolog B (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 3) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10B)	Danio rerio (Zebrafish) (Brachydanio rerio)	tRNA N1-guanine methylation [GO:0002939]	tRNA (guanosine(9)-N1)-methyltransferase activity [GO:0052905]; tRNA binding [GO:0000049]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000049; GO:0002939; GO:0005634; GO:0005654; GO:0052905
GN007161	GN007161.1	Q9CWD8	70.5	264	270	319	3.70e-131	377	NUBPL_MOUSE	Iron-sulfur cluster transfer protein NUBPL (Nucleotide-binding protein-like)	Mus musculus (Mouse)	iron-sulfur cluster assembly [GO:0016226]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrion organization [GO:0007005]	4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0005524; GO:0005739; GO:0005759; GO:0005886; GO:0007005; GO:0016226; GO:0032981; GO:0051539; GO:0140663
GN007162	GN007162.1	O08760	57.1	203	311	345	1.92e-77	243	OGG1_MOUSE	N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]	Mus musculus (Mouse)	base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; cellular response to reactive oxygen species [GO:0034614]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of double-strand break repair via single-strand annealing [GO:1901291]; nucleotide-excision repair [GO:0006289]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; response to estradiol [GO:0032355]; response to oxidative stress [GO:0006979]; response to radiation [GO:0009314]	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]; enzyme binding [GO:0019899]; microtubule binding [GO:0008017]; oxidized base lesion DNA N-glycosylase activity [GO:0000702]; oxidized purine DNA binding [GO:0032357]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000702; GO:0000978; GO:0003677; GO:0003684; GO:0005634; GO:0005654; GO:0005739; GO:0006281; GO:0006284; GO:0006285; GO:0006289; GO:0006355; GO:0006974; GO:0006979; GO:0008017; GO:0008534; GO:0009314; GO:0016363; GO:0016607; GO:0019104; GO:0019899; GO:0032355; GO:0032357; GO:0032991; GO:0034039; GO:0034614; GO:0043066; GO:0044029; GO:0045944; GO:0140078; GO:1901291
GN007163	GN007163.1	A6PVS8	50.7	203	801	624	7.97e-61	220	LRIQ3_HUMAN	Leucine-rich repeat and IQ domain-containing protein 3 (Leucine-rich repeat-containing protein 44)	Homo sapiens (Human)				
GN007164	GN007164.1	Q68FX0	64.0	361	389	385	1.09e-155	446	IDH3B_RAT	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta)	Rattus norvegicus (Rat)	tricarboxylic acid cycle [GO:0006099]	enzyme activator activity [GO:0008047]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	isocitrate dehydrogenase complex (NAD+) [GO:0045242]; mitochondrion [GO:0005739]	GO:0000287; GO:0005739; GO:0006099; GO:0008047; GO:0016616; GO:0045242; GO:0051287
GN007170	GN007170.1	A2AX52	35.7	196	730	2309	2.26e-21	103	CO6A4_MOUSE	Collagen alpha-4(VI) chain	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]	collagen binding [GO:0005518]	collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991]	GO:0005518; GO:0005576; GO:0005589; GO:0030198; GO:0031012; GO:0032991
GN007171	GN007171.1	P32321	57.5	146	195	178	1.04e-59	187	DCTD_HUMAN	Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase)	Homo sapiens (Human)	dTMP biosynthetic process [GO:0006231]; dUMP biosynthetic process [GO:0006226]; nucleoside salvage [GO:0043174]; pyrimidine nucleotide metabolic process [GO:0006220]	5-hydroxymethyl-dUMP N-hydrolase activity [GO:0070694]; dCMP deaminase activity [GO:0004132]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]	GO:0004132; GO:0005829; GO:0006220; GO:0006226; GO:0006231; GO:0008270; GO:0042802; GO:0043174; GO:0070694
GN007172	GN007172.1	Q5RC69	68.7	150	169	178	6.07e-76	227	DCTD_PONAB	Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	nucleoside salvage [GO:0043174]; pyrimidine nucleotide metabolic process [GO:0006220]	5-hydroxymethyl-dUMP N-hydrolase activity [GO:0070694]; dCMP deaminase activity [GO:0004132]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0004132; GO:0005737; GO:0006220; GO:0008270; GO:0043174; GO:0070694
GN007173	GN007173.1	Q9Z1M8	59.4	586	596	557	1.70e-156	463	RED_MOUSE	Protein Red (Cytokine IK) (IK factor) (Protein RER)	Mus musculus (Mouse)	mitotic cell cycle [GO:0000278]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA splicing, via spliceosome [GO:0000398]; protein localization to kinetochore [GO:0034501]	identical protein binding [GO:0042802]	chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; U2-type precatalytic spliceosome [GO:0071005]	GO:0000278; GO:0000398; GO:0000922; GO:0005634; GO:0005654; GO:0005694; GO:0007094; GO:0016607; GO:0034501; GO:0042802; GO:0071005
GN007175	GN007175.1	O75665	28.9	692	1009	1012	7.27e-62	232	OFD1_HUMAN	Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A)	Homo sapiens (Human)	cilium assembly [GO:0060271]; embryonic body morphogenesis [GO:0010172]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]	alpha-tubulin binding [GO:0043014]; gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; motile cilium [GO:0031514]; nucleus [GO:0005634]	GO:0005576; GO:0005634; GO:0005813; GO:0005814; GO:0005829; GO:0005929; GO:0010172; GO:0016020; GO:0031514; GO:0034451; GO:0036064; GO:0042802; GO:0043014; GO:0043015; GO:0060090; GO:0060271; GO:0060287
GN007176	GN007176.1	Q3UTQ8	77.0	296	1067	938	4.03e-149	472	CDKL5_MOUSE	Cyclin-dependent kinase-like 5 (EC 2.7.11.22)	Mus musculus (Mouse)	modulation of chemical synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of Rac protein signal transduction [GO:0035022]; protein localization to nucleus [GO:0034504]; regulation of cilium assembly [GO:1902017]; regulation of dendrite development [GO:0050773]; regulation of postsynapse organization [GO:0099175]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; small GTPase binding [GO:0031267]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; dendrite cytoplasm [GO:0032839]; dendritic growth cone [GO:0044294]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density, intracellular component [GO:0099092]; ruffle membrane [GO:0032587]	GO:0001764; GO:0004672; GO:0004693; GO:0005524; GO:0005634; GO:0005654; GO:0005813; GO:0016301; GO:0031267; GO:0032587; GO:0032839; GO:0034504; GO:0035022; GO:0036064; GO:0044294; GO:0045773; GO:0048471; GO:0050773; GO:0050775; GO:0050804; GO:0060999; GO:0097542; GO:0098978; GO:0099092; GO:0099175; GO:0106310; GO:1902017
GN007177	GN007177.1	Q8IZU2	53.1	1302	1280	1322	0.0	1177	WDR17_HUMAN	WD repeat-containing protein 17	Homo sapiens (Human)				
GN007178	GN007178.1	Q9NWZ8	32.0	231	343	242	1.12e-23	100	GEMI8_HUMAN	Gem-associated protein 8 (Gemin-8) (Protein FAM51A1)	Homo sapiens (Human)	spliceosomal snRNP assembly [GO:0000387]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of Cajal bodies [GO:0097504]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]	GO:0000387; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0032797; GO:0034719; GO:0097504
GN007182	GN007182.1	Q6RG02	23.1	389	450	2586	2.91e-24	110	VIT_PENME	Vitellogenin [Cleaved into: Vitellin]	Penaeus merguiensis (Banana prawn) (Fenneropenaeus merguiensis)	lipid storage [GO:0019915]; lipid transport [GO:0006869]; oogenesis [GO:0048477]	lipid carrier activity [GO:0005319]		GO:0005319; GO:0006869; GO:0019915; GO:0048477
GN007183	GN007183.1	Q9U943	29.6	267	247	3380	9.10e-31	123	APLP_LOCMI	Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)]	Locusta migratoria (Migratory locust)	lipid transport [GO:0006869]	lipid carrier activity [GO:0005319]	extracellular region [GO:0005576]	GO:0005319; GO:0005576; GO:0006869
GN007188	GN007188.1	Q5ZKN1	74.0	323	343	372	3.10e-171	483	CDK9_CHICK	Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 9)	Gallus gallus (Chicken)	positive regulation of protein localization to chromatin [GO:0120187]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase II [GO:0006368]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; P-TEFb complex [GO:0070691]	GO:0000307; GO:0004674; GO:0004693; GO:0005524; GO:0006366; GO:0006368; GO:0008353; GO:0032968; GO:0045944; GO:0070691; GO:0106310; GO:0120187
GN007189	GN007189.1	Q3T197	62.9	170	162	222	9.06e-57	180	STEEP_BOVIN	STING ER exit protein (STEEP)	Bos taurus (Bovine)	endoplasmic reticulum membrane organization [GO:0090158]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]	protein-macromolecule adaptor activity [GO:0030674]	cell body [GO:0044297]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005789; GO:0006888; GO:0030674; GO:0044297; GO:0090158
GN007194	GN007194.1	P22488	36.8	565	619	576	3.38e-73	248	IFEA_CORAP	Non-neuronal cytoplasmic intermediate filament protein (IF)	Cornu aspersum (Brown garden snail) (Helix aspersa)	heterochromatin formation [GO:0031507]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; protein localization to nuclear envelope [GO:0090435]	structural constituent of cytoskeleton [GO:0005200]	cytoplasm [GO:0005737]; nuclear lamina [GO:0005652]	GO:0005200; GO:0005652; GO:0005737; GO:0006998; GO:0007097; GO:0031507; GO:0051664; GO:0090435
GN007195	GN007195.1	Q5RA37	31.7	603	607	612	1.21e-62	221	RPAP2_PONAB	Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	PERK-mediated unfolded protein response [GO:0036499]; snRNA transcription [GO:0009301]	protein serine/threonine phosphatase activity [GO:0004722]; RNA polymerase core enzyme binding [GO:0043175]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription preinitiation complex [GO:0097550]	GO:0004722; GO:0005634; GO:0005737; GO:0008420; GO:0009301; GO:0036499; GO:0043175; GO:0097550
GN007196	GN007196.1	Q642A5	79.8	104	186	145	7.71e-50	160	DPOE3_RAT	DNA polymerase epsilon subunit 3 (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17)	Rattus norvegicus (Rat)	chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA-templated DNA replication [GO:0006261]; heterochromatin formation [GO:0031507]; leading strand elongation [GO:0006272]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]; regulation of DNA replication [GO:0006275]	chromatin DNA binding [GO:0031490]; protein heterodimerization activity [GO:0046982]	ATAC complex [GO:0140672]; CHRAC [GO:0008623]; epsilon DNA polymerase complex [GO:0008622]; pericentric heterochromatin [GO:0005721]	GO:0000122; GO:0005721; GO:0006261; GO:0006272; GO:0006275; GO:0006334; GO:0006338; GO:0006974; GO:0008622; GO:0008623; GO:0031490; GO:0031507; GO:0046982; GO:0140672
GN007202	GN007202.1	P84173	69.6	270	271	272	1.36e-134	384	PHB1_CHICK	Prohibitin 1	Gallus gallus (Chicken)			cell surface [GO:0009986]; cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial prohibitin complex [GO:0035632]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005737; GO:0005739; GO:0005743; GO:0005886; GO:0009986; GO:0035632
GN007206	GN007206.1	Q0P5W1	48.8	1395	1378	1427	0.0	1299	VPS8_MOUSE	Vacuolar protein sorting-associated protein 8 homolog	Mus musculus (Mouse)	endosomal vesicle fusion [GO:0034058]; protein targeting to vacuole [GO:0006623]	protein-membrane adaptor activity [GO:0043495]	CORVET complex [GO:0033263]; early endosome [GO:0005769]; late endosome [GO:0005770]	GO:0005769; GO:0005770; GO:0006623; GO:0033263; GO:0034058; GO:0043495
GN007207	GN007207.1	Q68CZ2	31.4	1555	1388	1445	1.50e-172	556	TENS3_HUMAN	Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6)	Homo sapiens (Human)	positive regulation of Rac protein signal transduction [GO:0035022]		cytosol [GO:0005829]; focal adhesion [GO:0005925]; podosome [GO:0002102]	GO:0002102; GO:0005829; GO:0005925; GO:0035022
GN007208	GN007208.1	P51903	77.5	240	243	417	1.44e-124	362	PGK_CHICK	Phosphoglycerate kinase (EC 2.7.2.3)	Gallus gallus (Chicken)	gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]	chromosome [GO:0005694]; cytosol [GO:0005829]	GO:0004618; GO:0005524; GO:0005694; GO:0005829; GO:0006094; GO:0006096; GO:0043531
GN007209	GN007209.1	Q95LI3	28.4	155	1249	801	4.58e-09	64.7	ZFY_BOVIN	Zinc finger Y-chromosomal protein	Bos taurus (Bovine)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0001228; GO:0005634; GO:0006357; GO:0046872
GN007210	GN007210.1	Q9NRN7	45.3	287	282	309	3.05e-76	237	ADPPT_HUMAN	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.7) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) (AASD-PPT) (LYS5 ortholog)	Homo sapiens (Human)	10-formyltetrahydrofolate catabolic process [GO:0009258]; pantothenate metabolic process [GO:0015939]; protein maturation [GO:0051604]	holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0000287; GO:0005829; GO:0008897; GO:0009258; GO:0015939; GO:0051604; GO:0070062
GN007211	GN007211.1	Q9H1I8	39.8	742	742	757	3.78e-150	459	ASCC2_HUMAN	Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100)	Homo sapiens (Human)	DNA alkylation repair [GO:0006307]; DNA replication [GO:0006260]; regulation of DNA-templated transcription [GO:0006355]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; ubiquitin binding [GO:0043130]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; DNA repair complex [GO:1990391]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RQC-trigger complex [GO:0180022]	GO:0005634; GO:0005654; GO:0005829; GO:0006260; GO:0006307; GO:0006355; GO:0016607; GO:0022626; GO:0032790; GO:0043130; GO:0070530; GO:0072344; GO:0180022; GO:1990116; GO:1990391
GN007212	GN007212.1	Q8R149	50.2	203	403	637	1.67e-42	160	BUD13_MOUSE	BUD13 homolog	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U12-type catalytic step 2 spliceosome [GO:0071018]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	GO:0000398; GO:0005634; GO:0005654; GO:0005681; GO:0005684; GO:0071005; GO:0071006; GO:0071018
GN007213	GN007213.1	Q9UHP3	42.2	1110	1123	1055	4.48e-251	742	UBP25_HUMAN	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)	Homo sapiens (Human)	immune response [GO:0006955]; interleukin-17-mediated signaling pathway [GO:0097400]; mRNA metabolic process [GO:0016071]; negative regulation of ERAD pathway [GO:1904293]; negative regulation of interleukin-17-mediated signaling pathway [GO:1903882]; negative regulation of response to oxidative stress [GO:1902883]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein modification process [GO:0036211]; protein-containing complex assembly [GO:0065003]; proteolysis [GO:0006508]; response to oxidative stress [GO:0006979]; stress-activated protein kinase signaling cascade [GO:0031098]	ATPase binding [GO:0051117]; cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; peptidase activity [GO:0008233]; SUMO binding [GO:0032183]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein peptidase activity [GO:0019783]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	GO:0004843; GO:0005634; GO:0005737; GO:0005783; GO:0005829; GO:0006508; GO:0006955; GO:0006979; GO:0008233; GO:0016071; GO:0016579; GO:0019783; GO:0031098; GO:0031625; GO:0032183; GO:0036211; GO:0043130; GO:0051117; GO:0065003; GO:0070536; GO:0071108; GO:0097400; GO:0101005; GO:1902883; GO:1903882; GO:1904293
GN007214	GN007214.1	Q8CJ27	31.7	2350	2900	3122	1.21e-110	401	ASPM_MOUSE	Abnormal spindle-like microcephaly-associated protein homolog (Calmodulin-binding protein Sha1) (Calmodulin-binding protein 1) (Spindle and hydroxyurea checkpoint abnormal protein)	Mus musculus (Mouse)	brain development [GO:0007420]; cerebral cortex development [GO:0021987]; developmental growth [GO:0048589]; forebrain neuroblast division [GO:0021873]; maintenance of centrosome location [GO:0051661]; male gonad development [GO:0008584]; meiotic spindle assembly [GO:0090306]; negative regulation of asymmetric cell division [GO:0045769]; negative regulation of neuron differentiation [GO:0045665]; neuron migration [GO:0001764]; neuronal stem cell population maintenance [GO:0097150]; oogenesis [GO:0048477]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of meiotic cell cycle [GO:0051445]; spermatogenesis [GO:0007283]; spindle localization [GO:0051653]; spindle organization [GO:0007051]	calmodulin binding [GO:0005516]	apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; meiotic spindle [GO:0072687]; microtubule [GO:0005874]; microtubule minus-end [GO:0036449]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]; spindle pole [GO:0000922]	GO:0000922; GO:0001764; GO:0002052; GO:0005516; GO:0005634; GO:0005737; GO:0005813; GO:0005874; GO:0007051; GO:0007283; GO:0007420; GO:0008584; GO:0016324; GO:0021873; GO:0021987; GO:0030496; GO:0036449; GO:0045665; GO:0045769; GO:0048477; GO:0048589; GO:0051445; GO:0051653; GO:0051661; GO:0072687; GO:0090263; GO:0090306; GO:0097150; GO:0097431
GN007215	GN007215.1	Q920Q8	27.0	267	552	642	1.31e-21	102	NS1BP_MOUSE	Influenza virus NS1A-binding protein homolog (NS1-BP) (NS1-binding protein homolog) (Kelch family protein Nd1-L) (ND1-L2) (Nd1-S)	Mus musculus (Mouse)	negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of protein ubiquitination [GO:0031397]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; response to virus [GO:0009615]; RNA splicing [GO:0008380]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0008380; GO:0009615; GO:0031397; GO:0031463; GO:0043161; GO:1990756; GO:2001243
GN007216	GN007216.1	Q17GZ9	42.0	710	714	655	6.23e-160	479	ARP5_AEDAE	Actin-related protein 5	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	chromatin remodeling [GO:0006338]; regulation of DNA-templated transcription [GO:0006355]		nucleus [GO:0005634]	GO:0005634; GO:0006338; GO:0006355
GN007218	GN007218.1	Q5F3U9	49.1	1146	1460	1412	0.0	1088	PDS5B_CHICK	Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor)	Gallus gallus (Chicken)	mitotic sister chromatid cohesion [GO:0007064]; negative regulation of cell population proliferation [GO:0008285]	cohesin unloader activity [GO:0140670]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0007064; GO:0008285; GO:0140670
GN007219	GN007219.1	Q8BZQ7	44.4	773	763	837	2.26e-213	625	ANC2_MOUSE	Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2)	Mus musculus (Mouse)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; negative regulation of gene expression [GO:0010629]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]		anaphase-promoting complex [GO:0005680]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005680; GO:0007091; GO:0010629; GO:0031145; GO:0031915; GO:0045773; GO:0050775; GO:0070936; GO:0070979; GO:0090129; GO:0141198
GN007220	GN007220.1	Q96MT7	45.4	1754	2024	1854	0.0	1280	CFA44_HUMAN	Cilia- and flagella-associated protein 44 (WD repeat-containing protein 52)	Homo sapiens (Human)	microtubule cytoskeleton organization [GO:0000226]; sperm axoneme assembly [GO:0007288]	peptidase activity [GO:0008233]	axoneme [GO:0005930]; motile cilium [GO:0031514]	GO:0000226; GO:0005930; GO:0007288; GO:0008233; GO:0031514
GN007221	GN007221.1	Q8IZE3	36.0	442	799	742	7.08e-84	286	PACE1_HUMAN	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3)	Homo sapiens (Human)	cell migration [GO:0016477]	ATP binding [GO:0005524]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]	GO:0005524; GO:0005737; GO:0005794; GO:0005829; GO:0016477; GO:0030027
GN007224	GN007224.1	A4IIK1	24.9	638	1161	997	1.87e-49	194	MFHA1_XENTR	Malignant fibrous histiocytoma-amplified sequence 1 homolog	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	regulation of signal transduction [GO:0009966]		cytoplasm [GO:0005737]	GO:0005737; GO:0009966
GN007225	GN007225.1	Q5IS68	52.3	195	251	594	3.45e-63	210	DCE1_PANTR	Glutamate decarboxylase 1 (EC 4.1.1.15) (67 kDa glutamic acid decarboxylase) (GAD-67) (Glutamate decarboxylase 67 kDa isoform)	Pan troglodytes (Chimpanzee)	GABA biosynthetic process [GO:0009449]; GABA shunt [GO:0006540]	glutamate decarboxylase activity [GO:0004351]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]	axon terminus [GO:0043679]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; perinuclear region of cytoplasm [GO:0048471]; presynaptic active zone [GO:0048786]	GO:0004351; GO:0005737; GO:0005938; GO:0006540; GO:0009449; GO:0030170; GO:0042802; GO:0043679; GO:0048471; GO:0048786; GO:0060077; GO:0098982
GN007226	GN007226.1	Q3U0L2	44.9	147	303	486	9.23e-30	120	AN33B_MOUSE	Ankyrin repeat domain-containing protein 33B	Mus musculus (Mouse)				
GN007227	GN007227.1	Q460N3	27.2	460	461	678	4.91e-17	87.4	PAR15_HUMAN	Protein mono-ADP-ribosyltransferase PARP15 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) (Poly [ADP-ribose] polymerase 15) (PARP-15)	Homo sapiens (Human)	negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein poly-ADP-ribosylation [GO:0070212]	NAD+ binding [GO:0070403]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000122; GO:0003714; GO:0003950; GO:0005634; GO:0005737; GO:0010629; GO:0070212; GO:0070403; GO:0140806; GO:0140807; GO:1990404
GN007229	GN007229.1	Q922V4	85.8	330	330	513	1.57e-96	298	PLRG1_MOUSE	Pleiotropic regulator 1	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein localization to nucleus [GO:0034504]		catalytic step 2 spliceosome [GO:0071013]; DNA replication factor A complex [GO:0005662]; fibrillar center [GO:0001650]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U12-type catalytic step 2 spliceosome [GO:0071018]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000398; GO:0000974; GO:0001650; GO:0005634; GO:0005654; GO:0005662; GO:0005681; GO:0016607; GO:0031965; GO:0034504; GO:0071006; GO:0071007; GO:0071013; GO:0071014; GO:0071018; GO:0071020; GO:1900087
GN007230	GN007230.1	Q8K0U4	32.0	541	505	675	2.34e-86	282	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007231	GN007231.1	Q8K0U4	35.2	512	471	675	6.88e-85	277	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007232	GN007232.1	Q96MM6	42.9	98	115	686	2.49e-09	56.6	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN007233	GN007233.1	Q9CZJ2	39.4	104	164	685	2.65e-12	67.0	HS12B_MOUSE	Heat shock 70 kDa protein 12B	Mus musculus (Mouse)	angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]			GO:0001525; GO:0043542
GN007234	GN007234.1	Q8K0U4	30.7	358	355	675	1.04e-39	152	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007235	GN007235.1	Q922J3	56.6	76	2000	1391	3.12e-18	95.9	CLIP1_MOUSE	CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 170) (CLIP-170) (Restin)	Mus musculus (Mouse)	cytoplasmic microtubule organization [GO:0031122]; microtubule bundle formation [GO:0001578]; positive regulation of dendrite development [GO:1900006]; positive regulation of microtubule polymerization [GO:0031116]; protein transport into plasma membrane raft [GO:0044861]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; ruffle [GO:0001726]	GO:0001578; GO:0001726; GO:0005634; GO:0005635; GO:0005813; GO:0005829; GO:0005874; GO:0005881; GO:0005938; GO:0008017; GO:0008270; GO:0015630; GO:0015631; GO:0030659; GO:0031116; GO:0031122; GO:0035371; GO:0042802; GO:0044861; GO:0051010; GO:1900006
GN007236	GN007236.1	P36956	39.5	860	1103	1147	8.16e-163	515	SRBP1_HUMAN	Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]	Homo sapiens (Human)	cellular response to fatty acid [GO:0071398]; cellular response to insulin stimulus [GO:0032869]; cellular response to starvation [GO:0009267]; cholesterol metabolic process [GO:0008203]; circadian rhythm [GO:0007623]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; negative regulation of triglyceride metabolic process [GO:0090209]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of mitophagy [GO:1901524]; regulation of protein localization to mitochondrion [GO:1903747]; regulation of protein stability [GO:0031647]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to fructose [GO:0009750]; response to glucagon [GO:0033762]; response to nutrient [GO:0007584]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; SREBP signaling pathway [GO:0032933]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; sterol response element binding [GO:0032810]; transcription coregulator binding [GO:0001221]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SREBP-SCAP complex [GO:0032936]; SREBP-SCAP-Insig complex [GO:0032937]	GO:0000139; GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001221; GO:0001228; GO:0003677; GO:0003682; GO:0003700; GO:0004879; GO:0005634; GO:0005635; GO:0005654; GO:0005737; GO:0005783; GO:0005789; GO:0005794; GO:0005829; GO:0006357; GO:0006629; GO:0007584; GO:0007623; GO:0008203; GO:0008610; GO:0009267; GO:0009410; GO:0009750; GO:0010867; GO:0012507; GO:0019901; GO:0030324; GO:0031647; GO:0032094; GO:0032526; GO:0032570; GO:0032810; GO:0032869; GO:0032933; GO:0032936; GO:0032937; GO:0033762; GO:0044877; GO:0045471; GO:0045542; GO:0045944; GO:0046983; GO:0051591; GO:0071398; GO:0090209; GO:1901524; GO:1902895; GO:1903747; GO:1990837
GN007237	GN007237.1	O08623	35.8	338	335	439	1.02e-36	140	SQSTM_RAT	Sequestosome-1 (Protein kinase C-zeta-interacting protein) (PKC-zeta-interacting protein) (Ubiquitin-binding protein p62)	Rattus norvegicus (Rat)	aggrephagy [GO:0035973]; autophagy [GO:0006914]; brown fat cell proliferation [GO:0070342]; cellular response to stress [GO:0033554]; endosome organization [GO:0007032]; energy homeostasis [GO:0097009]; macroautophagy [GO:0016236]; membraneless organelle assembly [GO:0140694]; mitophagy [GO:0000423]; negative regulation of ferroptosis [GO:0110076]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pexophagy [GO:0000425]; positive regulation of autophagy [GO:0010508]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein phosphorylation [GO:0006468]; protein targeting to vacuole involved in autophagy [GO:0071211]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of protein complex stability [GO:0061635]; response to ischemia [GO:0002931]; response to mitochondrial depolarisation [GO:0098780]; temperature homeostasis [GO:0001659]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular condensate scaffold activity [GO:0140693]; molecular sequestering activity [GO:0140313]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor activity [GO:0038023]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-modified protein reader activity [GO:0140036]; zinc ion binding [GO:0008270]	aggresome [GO:0016235]; amphisome [GO:0044753]; autolysosome [GO:0044754]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; inclusion body [GO:0016234]; intracellular membraneless organelle [GO:0043232]; late endosome [GO:0005770]; Lewy body [GO:0097413]; lysosome [GO:0005764]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; phagophore assembly site [GO:0000407]; PML body [GO:0016605]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]; synapse [GO:0045202]	GO:0000122; GO:0000407; GO:0000423; GO:0000425; GO:0001659; GO:0001934; GO:0002931; GO:0005080; GO:0005634; GO:0005737; GO:0005739; GO:0005764; GO:0005770; GO:0005776; GO:0005783; GO:0005829; GO:0006468; GO:0006606; GO:0006914; GO:0007032; GO:0008270; GO:0010508; GO:0016234; GO:0016235; GO:0016236; GO:0016605; GO:0019899; GO:0019901; GO:0030017; GO:0030163; GO:0030674; GO:0031397; GO:0031625; GO:0033554; GO:0034144; GO:0035255; GO:0035591; GO:0035973; GO:0036464; GO:0038023; GO:0042169; GO:0042802; GO:0043122; GO:0043130; GO:0043232; GO:0044753; GO:0044754; GO:0044877; GO:0045202; GO:0061635; GO:0070342; GO:0070530; GO:0071211; GO:0097009; GO:0097225; GO:0097413; GO:0098780; GO:0098978; GO:0110076; GO:0140036; GO:0140311; GO:0140313; GO:0140693; GO:0140694; GO:1900273; GO:1903078; GO:1905719
GN007238	GN007238.1	Q32NR4	39.8	427	526	487	8.94e-57	200	TTC29_XENLA	Tetratricopeptide repeat protein 29 (TPR repeat protein 29)	Xenopus laevis (African clawed frog)	cilium movement [GO:0003341]		sperm flagellum [GO:0036126]	GO:0003341; GO:0036126
GN007242	GN007242.1	Q7Z4T9	56.2	726	749	767	1.65e-253	724	CFA91_HUMAN	Cilia- and flagella-associated protein 91 (CFAP91) (AMY-1-associating protein expressed in testis 1) (AAT-1) (MYCBP/AMY-1-associated testis-expressed protein 1) (Protein MAATS1)	Homo sapiens (Human)	axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; spermatogenesis [GO:0007283]		axoneme [GO:0005930]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]	GO:0003341; GO:0005737; GO:0005739; GO:0005930; GO:0007283; GO:0031514; GO:1904158
GN007243	GN007243.1	Q96KN3	54.0	341	442	472	8.74e-104	319	PKNX2_HUMAN	Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)	Homo sapiens (Human)	positive regulation of transcription by RNA polymerase II [GO:0045944]	actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]	GO:0000978; GO:0003700; GO:0003785; GO:0005654; GO:0005737; GO:0015629; GO:0015630; GO:0045944; GO:0051015; GO:1990837
GN007246	GN007246.1	O08863	25.7	580	500	600	2.74e-40	156	BIRC3_MOUSE	Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 2) (C-IAP2) (Inhibitor of apoptosis protein 1) (mIAP1) (RING-type E3 ubiquitin transferase BIRC3)	Mus musculus (Mouse)	cellular response to tumor necrosis factor [GO:0071356]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; negative regulation of phosphorylation [GO:0042326]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of necroptotic process [GO:0060544]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; protein-containing complex binding [GO:0044877]; transferase activity [GO:0016740]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0016740; GO:0031398; GO:0032991; GO:0042326; GO:0042981; GO:0043027; GO:0043066; GO:0044877; GO:0051726; GO:0060544; GO:0060546; GO:0061630; GO:0070266; GO:0071356; GO:1901222; GO:1902916; GO:2000378
GN007247	GN007247.1	Q8WMV1	41.0	227	243	418	1.81e-41	149	ERG24_BOVIN	Delta(14)-sterol reductase TM7SF2 (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (Sterol C14-reductase) (Transmembrane 7 superfamily member 2)	Bos taurus (Bovine)	cholesterol biosynthetic process [GO:0006695]	Delta14-sterol reductase activity [GO:0050613]; NADP binding [GO:0050661]	endoplasmic reticulum membrane [GO:0005789]; nuclear inner membrane [GO:0005637]	GO:0005637; GO:0005789; GO:0006695; GO:0050613; GO:0050661
GN007248	GN007248.1	Q0KHZ6	74.3	249	255	253	6.18e-127	363	ETFB_DROME	Electron transfer flavoprotein subunit beta (Beta-ETF)	Drosophila melanogaster (Fruit fly)	fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]	electron transfer activity [GO:0009055]	mitochondrial electron transfer flavoprotein complex [GO:0017133]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0006635; GO:0009055; GO:0017133; GO:0033539
GN007250	GN007250.1	Q498J9	44.6	121	118	233	1.16e-23	94.0	MBLC1_XENLA	Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1)	Xenopus laevis (African clawed frog)	histone mRNA metabolic process [GO:0008334]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0008334; GO:0046872; GO:1900087
GN007256	GN007256.1	A5YVV0	30.6	602	685	661	1.71e-74	256	LAC3_ANOGA	Multicopper oxidase 3 (AgMCO3) (EC 1.10.3.2) (Laccase-3)	Anopheles gambiae (African malaria mosquito)		copper ion binding [GO:0005507]; hydroquinone:oxygen oxidoreductase activity [GO:0052716]	extracellular region [GO:0005576]	GO:0005507; GO:0005576; GO:0052716
GN007257	GN007257.1	Q9SN68	41.1	190	523	200	4.36e-40	147	RAF2B_ARATH	Ras-related protein RABF2b (AtRABF2b) (Ras-related protein Ara-7) (Ras-related protein Rab5B) (AtRab5B)	Arabidopsis thaliana (Mouse-ear cress)	intracellular protein transport [GO:0006886]; late endosome to vacuole transport [GO:0045324]; vacuole organization [GO:0007033]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular sequestering activity [GO:0140313]; small molecule binding [GO:0036094]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; endosome membrane [GO:0010008]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]	GO:0003924; GO:0005525; GO:0005737; GO:0005768; GO:0005769; GO:0005783; GO:0005886; GO:0006886; GO:0007033; GO:0010008; GO:0030139; GO:0031901; GO:0032585; GO:0036094; GO:0045324; GO:0140313
GN007259	GN007259.1	Q9SN68	41.7	163	217	200	2.31e-43	147	RAF2B_ARATH	Ras-related protein RABF2b (AtRABF2b) (Ras-related protein Ara-7) (Ras-related protein Rab5B) (AtRab5B)	Arabidopsis thaliana (Mouse-ear cress)	intracellular protein transport [GO:0006886]; late endosome to vacuole transport [GO:0045324]; vacuole organization [GO:0007033]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular sequestering activity [GO:0140313]; small molecule binding [GO:0036094]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; endosome membrane [GO:0010008]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]	GO:0003924; GO:0005525; GO:0005737; GO:0005768; GO:0005769; GO:0005783; GO:0005886; GO:0006886; GO:0007033; GO:0010008; GO:0030139; GO:0031901; GO:0032585; GO:0036094; GO:0045324; GO:0140313
GN007260	GN007260.1	O77775	30.2	149	499	527	8.31e-16	83.6	NCF2_BOVIN	Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (Neutrophil NADPH oxidase factor 2) (p67-phox)	Bos taurus (Bovine)	phagocytosis [GO:0006909]; respiratory burst [GO:0045730]; superoxide anion generation [GO:0042554]	superoxide-generating NADPH oxidase activator activity [GO:0016176]	cytoplasm [GO:0005737]; NADPH oxidase complex [GO:0043020]	GO:0005737; GO:0006909; GO:0016176; GO:0042554; GO:0043020; GO:0045730
GN007261	GN007261.1	Q8NHH1	52.6	289	364	710	9.28e-91	290	TTL11_HUMAN	Tubulin polyglutamylase TTLL11 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 11)	Homo sapiens (Human)	microtubule cytoskeleton organization [GO:0000226]; protein polyglutamylation [GO:0018095]	protein-glutamic acid ligase activity, elongating [GO:0106438]; protein-glutamic acid ligase activity, initiating [GO:0106437]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	ciliary basal body [GO:0036064]; cytosol [GO:0005829]	GO:0000226; GO:0005829; GO:0015631; GO:0018095; GO:0036064; GO:0070740; GO:0106437; GO:0106438
GN007264	GN007264.1	Q9WVC5	35.6	160	263	862	8.87e-17	83.2	TRPC7_MOUSE	Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (mTRP7)	Mus musculus (Mouse)	calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; manganese ion transport [GO:0006828]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338]	calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]	cation channel complex [GO:0034703]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0005262; GO:0005635; GO:0005886; GO:0006816; GO:0006828; GO:0007338; GO:0015279; GO:0016020; GO:0034703; GO:0048471; GO:0051480; GO:0070588; GO:0070679
GN007267	GN007267.1	P22727	51.1	333	313	364	1.39e-121	356	WNT6_MOUSE	Protein Wnt-6	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; axis specification [GO:0009798]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cell-cell signaling [GO:0007267]; epithelial-mesenchymal cell signaling [GO:0060684]; nephron tubule development [GO:0072080]; nephron tubule formation [GO:0072079]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of tooth mineralization [GO:0070172]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]	GO:0001658; GO:0005102; GO:0005109; GO:0005125; GO:0005788; GO:0007165; GO:0007267; GO:0009798; GO:0009887; GO:0009986; GO:0010628; GO:0016055; GO:0030182; GO:0031012; GO:0042475; GO:0045165; GO:0045893; GO:0060070; GO:0060684; GO:0070172; GO:0072079; GO:0072080
GN007269	GN007269.1	O57594	37.4	155	365	359	9.68e-19	89.7	SURF6_TAKRU	Surfeit locus protein 6 homolog	Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)	ribosomal large subunit biogenesis [GO:0042273]; ribosomal small subunit biogenesis [GO:0042274]	DNA binding [GO:0003677]; RNA binding [GO:0003723]	nucleolus [GO:0005730]	GO:0003677; GO:0003723; GO:0005730; GO:0042273; GO:0042274
GN007270	GN007270.1	Q03164	32.5	995	3827	3969	3.17e-139	496	KMT2A_HUMAN	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	Homo sapiens (Human)	cellular response to transforming growth factor beta stimulus [GO:0071560]; circadian regulation of gene expression [GO:0032922]; definitive hemopoiesis [GO:0060216]; embryonic hemopoiesis [GO:0035162]; membrane depolarization [GO:0051899]; negative regulation of DNA methylation-dependent heterochromatin formation [GO:0090310]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; response to potassium ion [GO:0035864]; T-helper 2 cell differentiation [GO:0045064]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromatin binding [GO:0003682]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone H3K4 trimethyltransferase activity [GO:0140999]; identical protein binding [GO:0042802]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein homodimerization activity [GO:0042803]; protein-cysteine methyltransferase activity [GO:0106363]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003680; GO:0003682; GO:0005634; GO:0005654; GO:0005829; GO:0008270; GO:0032922; GO:0035097; GO:0035162; GO:0035864; GO:0042800; GO:0042802; GO:0042803; GO:0045064; GO:0045322; GO:0045815; GO:0045893; GO:0045944; GO:0051899; GO:0060216; GO:0065003; GO:0071339; GO:0071560; GO:0090310; GO:0106363; GO:0140945; GO:0140999
GN007271	GN007271.1	Q6RFL5	59.5	168	240	233	9.88e-48	160	BSH_CHICK	Brain-specific homeobox protein homolog	Gallus gallus (Chicken)	brain development [GO:0007420]; cell differentiation [GO:0030154]; eating behavior [GO:0042755]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell population maintenance [GO:0019827]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0007420; GO:0019827; GO:0030154; GO:0042755
GN007277	GN007277.1	Q86Z23	36.4	140	164	238	1.12e-17	80.1	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN007278	GN007278.1	Q5XIG2	31.9	138	174	281	3.47e-13	68.9	C1QT1_RAT	Complement C1q tumor necrosis factor-related protein 1	Rattus norvegicus (Rat)	negative regulation of platelet activation [GO:0010544]; negative regulation of platelet aggregation [GO:0090331]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of glucose metabolic process [GO:0010906]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005518; GO:0005576; GO:0005886; GO:0007204; GO:0010544; GO:0010628; GO:0010906; GO:0042802; GO:0043410; GO:0051897; GO:0090331; GO:2000860
GN007279	GN007279.1	P24733	79.0	1929	1960	1938	0.0	1407	MYS_ARGIR	Myosin heavy chain, striated muscle	Argopecten irradians (Bay scallop) (Aequipecten irradians)	locomotion [GO:0040011]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; myosin filament organization [GO:0031033]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; structural constituent of muscle [GO:0008307]	myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]	GO:0000146; GO:0005524; GO:0006936; GO:0008307; GO:0016460; GO:0030016; GO:0030239; GO:0031033; GO:0032982; GO:0040011; GO:0051015
GN007281	GN007281.1	P14866	55.3	85	93	589	3.70e-24	97.8	HNRPL_HUMAN	Heterogeneous nuclear ribonucleoprotein L (hnRNP L)	Homo sapiens (Human)	mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA processing [GO:0006396]	pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pronucleus [GO:0045120]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770]; synapse [GO:0045202]	GO:0000381; GO:0000785; GO:0000976; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006396; GO:0006397; GO:0016020; GO:0035770; GO:0045120; GO:0045202; GO:0045892; GO:0070062; GO:0097157; GO:1990904
GN007289	GN007289.1	Q80WQ9	29.3	150	201	1168	2.66e-13	71.2	ZBED4_MOUSE	Zinc finger BED domain-containing protein 4	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; RNA binding [GO:0003723]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor inner segment [GO:0001917]	GO:0000976; GO:0000977; GO:0001228; GO:0001917; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0042802; GO:0045944; GO:0046983
GN007296	GN007296.1	Q24488	40.2	127	226	685	1.69e-18	87.0	ROR1_DROME	Tyrosine-protein kinase transmembrane receptor Ror (dRor) (EC 2.7.10.1)	Drosophila melanogaster (Fruit fly)	cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; central nervous system development [GO:0007417]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; Wnt-protein binding [GO:0017147]	axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004713; GO:0004714; GO:0005524; GO:0005886; GO:0006468; GO:0007169; GO:0007417; GO:0016020; GO:0017147; GO:0030424; GO:0043235
GN007297	GN007297.1	A0A345BJN8	31.0	248	606	919	3.07e-24	111	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN007301	GN007301.1	P51583	66.4	330	331	425	3.02e-164	467	PUR6_RAT	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)]	Rattus norvegicus (Rat)	'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; G1/S transition of mitotic cell cycle [GO:0000082]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113]	identical protein binding [GO:0042802]; phosphoribosylaminoimidazole carboxylase activity [GO:0004638]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0000082; GO:0004638; GO:0004639; GO:0005737; GO:0005829; GO:0006177; GO:0006189; GO:0009113; GO:0042802; GO:0044208; GO:0097294
GN007303	GN007303.1	Q06203	66.4	220	201	517	3.56e-96	291	PUR1_HUMAN	Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT)	Homo sapiens (Human)	'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; 'de novo' XMP biosynthetic process [GO:0097294]; GMP biosynthetic process [GO:0006177]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleotide biosynthetic process [GO:0006164]	amidophosphoribosyltransferase activity [GO:0004044]	cytosol [GO:0005829]	GO:0004044; GO:0005829; GO:0006164; GO:0006177; GO:0006189; GO:0009113; GO:0044208; GO:0097294
GN007317	GN007317.1	Q27J81	29.2	1020	2221	1249	4.50e-101	359	INF2_HUMAN	Inverted formin-2 (HBEBP2-binding protein C)	Homo sapiens (Human)	actin filament polymerization [GO:0030041]; regulation of mitochondrial fission [GO:0090140]	actin binding [GO:0003779]; small GTPase binding [GO:0031267]	actin filament [GO:0005884]; perinuclear region of cytoplasm [GO:0048471]	GO:0003779; GO:0005884; GO:0030041; GO:0031267; GO:0048471; GO:0090140
GN007318	GN007318.1	Q96B26	52.3	195	206	276	8.30e-69	214	EXOS8_HUMAN	Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9)	Homo sapiens (Human)	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]	identical protein binding [GO:0042802]; mRNA 3'-UTR AU-rich region binding [GO:0035925]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; fibrillar center [GO:0001650]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000176; GO:0000177; GO:0000178; GO:0000467; GO:0001650; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006396; GO:0006401; GO:0016075; GO:0034473; GO:0034475; GO:0034476; GO:0035925; GO:0042802; GO:0071028; GO:0071035; GO:0071038; GO:0101019
GN007320	GN007320.1	Q6IRM9	25.2	306	316	597	1.61e-30	124	ZWILC_XENLA	Protein zwilch homolog	Xenopus laevis (African clawed frog)	mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]		RZZ complex [GO:1990423]	GO:0007094; GO:0034501; GO:1990423
GN007327	GN007327.1	Q0P651	40.0	442	498	464	5.91e-106	327	ABD18_HUMAN	Cardiolipin-specific deacylase, mitochondrial (Alpha/beta hydrolase domain-containing protein 18) (Abhydrolase domain-containing protein 18)	Homo sapiens (Human)			mitochondrion [GO:0005739]	GO:0005739
GN007328	GN007328.1	Q8MQJ9	47.2	864	766	1037	2.56e-182	551	BRAT_DROME	Protein brain tumor	Drosophila melanogaster (Fruit fly)	asymmetric cell division [GO:0008356]; asymmetric neuroblast division resulting in ganglion mother cell formation [GO:0055060]; brain development [GO:0007420]; ganglion mother cell fate determination [GO:0007402]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of translation [GO:0017148]; neural precursor cell proliferation [GO:0061351]; neuroblast development [GO:0014019]; neuroblast differentiation [GO:0014016]; neuroblast fate determination [GO:0007400]; neuroblast proliferation [GO:0007405]; neuron differentiation [GO:0030182]; oogenesis [GO:0048477]; regulation of neuroblast proliferation [GO:1902692]; regulation of neurogenesis [GO:0050767]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of translation [GO:0006417]; rRNA transcription [GO:0009303]; segmentation [GO:0035282]; ventral cord development [GO:0007419]	mRNA 3'-UTR binding [GO:0003730]; translation regulator activity [GO:0045182]; translation repressor activity [GO:0030371]; zinc ion binding [GO:0008270]	apical cortex [GO:0045179]; basal cortex [GO:0045180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]	GO:0003730; GO:0005737; GO:0005829; GO:0006417; GO:0007400; GO:0007402; GO:0007405; GO:0007406; GO:0007419; GO:0007420; GO:0008270; GO:0008285; GO:0008356; GO:0008582; GO:0009303; GO:0010629; GO:0014016; GO:0014019; GO:0017148; GO:0030182; GO:0030371; GO:0035282; GO:0043025; GO:0045179; GO:0045180; GO:0045182; GO:0048477; GO:0050767; GO:0055060; GO:0061351; GO:1900242; GO:1902692
GN007329	GN007329.1	O14656	48.4	246	252	332	6.54e-78	241	TOR1A_HUMAN	Torsin-1A (Dystonia 1 protein) (Torsin ATPase-1A) (EC 3.6.4.-) (Torsin family 1 member A)	Homo sapiens (Human)	cell adhesion [GO:0007155]; ERAD pathway [GO:0036503]; intermediate filament cytoskeleton organization [GO:0045104]; neuron projection development [GO:0031175]; nuclear envelope organization [GO:0006998]; nuclear membrane organization [GO:0071763]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; protein deneddylation [GO:0000338]; protein folding [GO:0006457]; protein localization to nucleus [GO:0034504]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of protein localization to cell surface [GO:2000008]; response to oxidative stress [GO:0006979]; synaptic vesicle membrane organization [GO:0048499]; synaptic vesicle transport [GO:0048489]; wound healing, spreading of cells [GO:0044319]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; misfolded protein binding [GO:0051787]	cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; secretory granule [GO:0030141]; synaptic vesicle [GO:0008021]	GO:0000338; GO:0005524; GO:0005635; GO:0005783; GO:0005788; GO:0005789; GO:0005829; GO:0005856; GO:0006457; GO:0006979; GO:0006998; GO:0007155; GO:0008021; GO:0008092; GO:0016020; GO:0016887; GO:0019894; GO:0030141; GO:0030426; GO:0030659; GO:0031175; GO:0031965; GO:0034504; GO:0036503; GO:0042802; GO:0044319; GO:0045104; GO:0048489; GO:0048499; GO:0051584; GO:0051787; GO:0070062; GO:0071763; GO:0140662; GO:1900244; GO:2000008
GN007330	GN007330.1	Q8VEH0	44.6	345	450	348	9.60e-102	310	TM144_MOUSE	Transmembrane protein 144	Mus musculus (Mouse)		carbohydrate transmembrane transporter activity [GO:0015144]	membrane [GO:0016020]	GO:0015144; GO:0016020
GN007331	GN007331.1	O96064	56.9	885	871	864	1.05e-168	514	MYSP_MYTGA	Paramyosin	Mytilus galloprovincialis (Mediterranean mussel)			myofibril [GO:0030016]; myosin complex [GO:0016459]	GO:0016459; GO:0030016
GN007332	GN007332.1	Q9EQN5	48.6	1027	1028	988	5.76e-292	841	SMBP2_RAT	DNA-binding protein SMUBP-2 (EC 5.6.2.3) (EC 5.6.2.5) (ATP-dependent helicase IGHMBP2) (Antifreeze enhancer-binding protein ortholog) (AEP) (DNA and RNA 5'-3' helicase IGHMBP2)	Rattus norvegicus (Rat)	DNA damage response [GO:0006974]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuromuscular process [GO:0050905]; spinal cord motor neuron differentiation [GO:0021522]	5'-3' DNA helicase activity [GO:0043139]; 5'-3' RNA helicase activity [GO:0032574]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent activity, acting on RNA [GO:0008186]; DNA binding [GO:0003677]; double-stranded DNA helicase activity [GO:0036121]; G-rich single-stranded DNA binding [GO:1990955]; general transcription initiation factor binding [GO:0140296]; identical protein binding [GO:0042802]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:1990904]	GO:0000049; GO:0000122; GO:0003677; GO:0003697; GO:0003723; GO:0003727; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006974; GO:0008094; GO:0008186; GO:0008270; GO:0016604; GO:0016887; GO:0021522; GO:0030424; GO:0030426; GO:0032574; GO:0036121; GO:0042802; GO:0043022; GO:0043025; GO:0043139; GO:0048471; GO:0050905; GO:0140296; GO:1990904; GO:1990955
GN007335	GN007335.1	Q10576	23.7	312	328	559	4.99e-13	73.2	P4HA1_CAEEL	Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) (Protein dumpy-18)	Caenorhabditis elegans	collagen and cuticulin-based cuticle development [GO:0040002]; cuticle development involved in collagen and cuticulin-based cuticle molting cycle [GO:0042338]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic body morphogenesis [GO:0010172]; IRE1-mediated unfolded protein response [GO:0036498]; positive regulation of multicellular organism growth [GO:0040018]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545]; procollagen-proline 4-dioxygenase activity [GO:0004656]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; procollagen-proline 4-dioxygenase complex [GO:0016222]	GO:0004656; GO:0005506; GO:0005783; GO:0005788; GO:0009792; GO:0010172; GO:0016222; GO:0031418; GO:0031545; GO:0036498; GO:0040002; GO:0040018; GO:0042338
GN007336	GN007336.1	A0A1U8QWA2	34.2	956	939	1270	1.73e-154	491	ATR12_EMENI	Glycine betaine reductase ATRR (Nonribosomal peptide synthetase-like protein ATRR) [Includes: Carboxylic acid reductase (EC 1.2.1.-); Aldehyde reductase (EC 1.1.1.-)]	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)	secondary metabolite biosynthetic process [GO:0044550]	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; phosphopantetheine binding [GO:0031177]		GO:0016616; GO:0031177; GO:0044550
GN007337	GN007337.1	Q6PAD2	42.1	988	1034	944	5.89e-210	629	PLK4_XENLA	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak)	Xenopus laevis (African clawed frog)	centriole replication [GO:0007099]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; positive regulation of centriole replication [GO:0046601]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centriole [GO:0005814]; centrosome [GO:0005813]; deuterosome [GO:0098536]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0004674; GO:0005524; GO:0005634; GO:0005730; GO:0005813; GO:0005814; GO:0007099; GO:0046601; GO:0098535; GO:0098536; GO:0106310
GN007338	GN007338.1	A7MB34	35.3	153	282	419	2.63e-10	63.9	F181B_BOVIN	Protein FAM181B	Bos taurus (Bovine)				
GN007339	GN007339.1	Q8WXW3	47.2	564	610	757	7.37e-162	484	PIBF1_HUMAN	Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90)	Homo sapiens (Human)	activation of Janus kinase activity [GO:0042976]; cilium assembly [GO:0060271]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of prostaglandin biosynthetic process [GO:0031393]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; non-motile cilium assembly [GO:1905515]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein localization to centrosome [GO:0071539]	interleukin-4 receptor binding [GO:0005136]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]	GO:0005136; GO:0005576; GO:0005634; GO:0005737; GO:0005813; GO:0005815; GO:0007080; GO:0031393; GO:0032695; GO:0032733; GO:0032815; GO:0034451; GO:0042531; GO:0042532; GO:0042976; GO:0060271; GO:0071539; GO:0090307; GO:1905515
GN007341	GN007341.1	Q01664	41.5	258	352	338	8.51e-38	141	TFAP4_HUMAN	Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41)	Homo sapiens (Human)	cellular response to dexamethasone stimulus [GO:0071549]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; host-mediated activation of viral transcription [GO:0043923]; host-mediated suppression of viral transcription [GO:0043922]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; protein-containing complex assembly [GO:0065003]; regulation of mitotic cell cycle phase transition [GO:1901990]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	GO:0000785; GO:0000976; GO:0000978; GO:0000981; GO:0001228; GO:0003677; GO:0005634; GO:0005654; GO:0006357; GO:0008285; GO:0010629; GO:0017053; GO:0030330; GO:0042803; GO:0042826; GO:0043065; GO:0043392; GO:0043565; GO:0043922; GO:0043923; GO:0045736; GO:0045892; GO:0045893; GO:0065003; GO:0070888; GO:0071549; GO:1901990; GO:1990837
GN007342	GN007342.1	Q3SWX0	55.7	341	441	360	1.51e-125	371	NIPA2_BOVIN	Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog)	Bos taurus (Bovine)	magnesium ion transport [GO:0015693]	magnesium ion transmembrane transporter activity [GO:0015095]	early endosome [GO:0005769]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005769; GO:0005886; GO:0015095; GO:0015693; GO:0016020
GN007344	GN007344.1	O43301	33.5	629	577	675	4.65e-114	357	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN007350	GN007350.1	Q9CZJ2	32.7	643	603	685	6.79e-101	324	HS12B_MOUSE	Heat shock 70 kDa protein 12B	Mus musculus (Mouse)	angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]			GO:0001525; GO:0043542
GN007352	GN007352.1	Q9NRZ9	36.1	299	410	838	4.44e-33	135	HELLS_HUMAN	Lymphoid-specific helicase (LSH) (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) (SMARCA6)	Homo sapiens (Human)	DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; kidney development [GO:0001822]; lymphocyte proliferation [GO:0046651]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; pericentric heterochromatin formation [GO:0031508]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of double-strand break [GO:0035861]	GO:0000724; GO:0000775; GO:0001822; GO:0003682; GO:0005524; GO:0005634; GO:0005694; GO:0005721; GO:0006302; GO:0006346; GO:0016887; GO:0031508; GO:0035861; GO:0044027; GO:0046651; GO:0140463; GO:0140658
GN007353	GN007353.1	Q4V835	63.8	265	310	838	2.70e-109	339	HELLS_XENLA	Lymphoid-specific helicase (LSH) (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) (SMARCA6)	Xenopus laevis (African clawed frog)	DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; double-strand break repair [GO:0006302]; lymphocyte proliferation [GO:0046651]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; pericentric heterochromatin formation [GO:0031508]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]	chromosome [GO:0005694]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	GO:0003682; GO:0005524; GO:0005634; GO:0005694; GO:0005721; GO:0006302; GO:0006346; GO:0016887; GO:0031508; GO:0044027; GO:0046651
GN007354	GN007354.1	O43301	32.8	640	566	675	2.74e-90	295	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN007355	GN007355.1	Q96MM6	35.1	641	626	686	1.26e-114	360	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN007357	GN007357.1	Q9UHF1	33.2	259	273	273	1.59e-30	118	EGFL7_HUMAN	Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)	Homo sapiens (Human)	blood vessel development [GO:0001568]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570]	calcium ion binding [GO:0005509]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0001568; GO:0001570; GO:0001938; GO:0005102; GO:0005509; GO:0005576; GO:0009986; GO:0031012; GO:0045746
GN007362	GN007362.1	Q556Y8	43.3	134	169	476	4.30e-29	114	DUSPR_DICDI	Probable rhodanese domain-containing dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48)	Dictyostelium discoideum (Social amoeba)	response to cisplatin [GO:0072718]; sorocarp development [GO:0030587]	MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine/threonine phosphatase activity [GO:0008330]		GO:0004721; GO:0004722; GO:0008330; GO:0017017; GO:0030587; GO:0033550; GO:0072718
GN007363	GN007363.1	Q9M8K7	38.5	143	167	167	2.16e-28	106	DUS1B_ARATH	Dual specificity protein phosphatase 1B (AtDsPTP1B) (EC 3.1.3.16) (EC 3.1.3.48) (MAPK phosphatase 2) (AtMKP2)	Arabidopsis thaliana (Mouse-ear cress)	cellular response to oxidative stress [GO:0034599]; intracellular signal transduction [GO:0035556]; negative regulation of plant-type hypersensitive response [GO:0034051]; response to oxidative stress [GO:0006979]; response to ozone [GO:0010193]	MAP kinase phosphatase activity [GO:0033549]; MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; protein kinase inhibitor activity [GO:0004860]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine/threonine phosphatase activity [GO:0008330]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0004722; GO:0004860; GO:0005634; GO:0005737; GO:0005886; GO:0006979; GO:0008330; GO:0010193; GO:0017017; GO:0033549; GO:0033550; GO:0034051; GO:0034599; GO:0035556
GN007364	GN007364.1	Q8WTR2	48.0	204	213	217	5.77e-55	177	DUS19_HUMAN	Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1) (SAPK pathway-regulating phosphatase 1)	Homo sapiens (Human)	negative regulation of JNK cascade [GO:0046329]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; regulation of JNK cascade [GO:0046328]	JUN kinase phosphatase activity [GO:0008579]; MAP kinase scaffold activity [GO:0005078]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein kinase activator activity [GO:0030295]; protein kinase inhibitor activity [GO:0004860]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]	GO:0004722; GO:0004725; GO:0004860; GO:0005078; GO:0005737; GO:0008138; GO:0008579; GO:0030295; GO:0031435; GO:0043410; GO:0046328; GO:0046329; GO:0046330
GN007366	GN007366.1	Q91790	38.0	142	149	369	1.88e-24	99.8	DUS1A_XENLA	Dual specificity protein phosphatase 1-A (EC 3.1.3.16) (EC 3.1.3.48) (XCL100) (XCL100-alfa)	Xenopus laevis (African clawed frog)	endoderm formation [GO:0001706]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of p38MAPK cascade [GO:1903753]; peptidyl-serine dephosphorylation [GO:0070262]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001706; GO:0004722; GO:0004725; GO:0005634; GO:0005737; GO:0017017; GO:0043409; GO:0051447; GO:0070262; GO:0090266; GO:1903753
GN007368	GN007368.1	A4IJ15	35.2	125	346	467	4.24e-09	61.2	CFA97_XENTR	Cilia- and flagella-associated protein 97	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)				
GN007370	GN007370.1	Q96NC0	72.8	191	360	199	5.93e-69	218	ZMAT2_HUMAN	Zinc finger matrin-type protein 2	Homo sapiens (Human)	mRNA splicing, via spliceosome [GO:0000398]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	GO:0000398; GO:0003676; GO:0005634; GO:0005654; GO:0008270; GO:0046540; GO:0071005
GN007371	GN007371.1	Q9D281	33.8	361	705	569	6.35e-45	172	NXP20_MOUSE	Protein Noxp20 (Nervous system overexpressed protein 20) (Protein FAM114A1)	Mus musculus (Mouse)	angiotensin-activated signaling pathway [GO:0038166]; connective tissue replacement [GO:0097709]; fibroblast activation [GO:0072537]; fibroblast migration [GO:0010761]; fibroblast proliferation [GO:0048144]; gene expression [GO:0010467]; heart valve morphogenesis [GO:0003179]; inflammatory response [GO:0006954]; tissue remodeling [GO:0048771]		cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	GO:0003179; GO:0005654; GO:0005794; GO:0005829; GO:0006954; GO:0010467; GO:0010761; GO:0038166; GO:0048144; GO:0048771; GO:0072537; GO:0097709
GN007372	GN007372.1	Q9MZ34	45.9	621	681	620	9.04e-179	525	SC6A6_BOVIN	Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) (Taurine transporter) (TauT)	Bos taurus (Bovine)	amino acid transport [GO:0006865]; negative regulation of cellular senescence [GO:2000773]; neurotransmitter transport [GO:0006836]; positive regulation of mitochondrial translation [GO:0070131]; sodium ion transmembrane transport [GO:0035725]; taurine transmembrane transport [GO:0015734]	gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; taurine:sodium symporter activity [GO:0005369]	mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]	GO:0005332; GO:0005369; GO:0005743; GO:0005886; GO:0006836; GO:0006865; GO:0015734; GO:0035725; GO:0070131; GO:2000773
GN007375	GN007375.1	Q08E39	43.0	158	252	315	2.17e-36	134	SPY2_BOVIN	Protein sprouty homolog 2 (Spry-2)	Bos taurus (Bovine)	cellular response to vascular endothelial growth factor stimulus [GO:0035924]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell projection organization [GO:0031345]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of cell migration [GO:0030335]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]	protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase inhibitor activity [GO:0030291]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]	GO:0004860; GO:0005634; GO:0005829; GO:0005856; GO:0010628; GO:0010719; GO:0015629; GO:0015630; GO:0016525; GO:0019901; GO:0030291; GO:0030335; GO:0030512; GO:0031345; GO:0031397; GO:0032587; GO:0035924; GO:0040037; GO:0042059; GO:0043066; GO:0043539; GO:0045742; GO:0046580; GO:0051897; GO:0070373; GO:0070374; GO:1900747; GO:1902747
GN007377	GN007377.1	D4A6L0	36.1	476	575	1202	2.16e-87	297	MGLYR_RAT	Metabotropic glycine receptor (mGlyR) (G protein-coupled receptor 158)	Rattus norvegicus (Rat)	brain development [GO:0007420]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of neurotransmitter secretion [GO:0001956]; protein localization to plasma membrane [GO:0072659]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synapse organization [GO:0050807]	enzyme activator activity [GO:0008047]; G protein-coupled glycine receptor activity [GO:0160079]; transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	GO:0001956; GO:0004888; GO:0005634; GO:0005886; GO:0007186; GO:0007420; GO:0008047; GO:0008277; GO:0016020; GO:0042734; GO:0045211; GO:0050807; GO:0050890; GO:0072659; GO:0098839; GO:0160079
GN007379	GN007379.1	O43301	30.9	621	621	675	5.10e-78	264	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN007383	GN007383.1	O16025	38.2	152	170	1066	2.26e-22	96.3	AOSL_PLEHO	Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (AOS) (EC 4.2.1.-) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)]	Plexaura homomalla (Black sea rod)	arachidonate metabolic process [GO:0019369]; lipid oxidation [GO:0034440]	arachidonate 8(R)-lipoxygenase activity [GO:0047677]; heme binding [GO:0020037]; iron ion binding [GO:0005506]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0005506; GO:0005737; GO:0016020; GO:0019369; GO:0020037; GO:0034440; GO:0047677
GN007384	GN007384.1	Q2I0E5	31.1	328	299	951	2.86e-21	97.4	INTU_XENLA	Protein inturned (Inturned planar cell polarity effector homolog) (Xint)	Xenopus laevis (African clawed frog)	ciliary basal body organization [GO:0032053]; cilium assembly [GO:0060271]; establishment of planar polarity [GO:0001736]; intracellular protein localization [GO:0008104]; nervous system development [GO:0007399]; regulation of smoothened signaling pathway [GO:0008589]; vesicle-mediated transport [GO:0016192]		apical part of cell [GO:0045177]; cell surface [GO:0009986]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0001736; GO:0005737; GO:0005886; GO:0005929; GO:0007399; GO:0008104; GO:0008589; GO:0009986; GO:0016192; GO:0032053; GO:0036064; GO:0045177; GO:0060271
GN007385	GN007385.1	P24643	63.8	486	960	593	1.77e-123	390	CALX_CANLF	Calnexin (pp90)	Canis lupus familiaris (Dog) (Canis familiaris)	clathrin-dependent endocytosis [GO:0072583]; ERAD pathway [GO:0036503]; protein folding [GO:0006457]; synaptic vesicle endocytosis [GO:0048488]	calcium ion binding [GO:0005509]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; melanosome membrane [GO:0033162]; mitochondrial membrane [GO:0031966]; presynapse [GO:0098793]	GO:0005509; GO:0005783; GO:0005789; GO:0006457; GO:0031966; GO:0033162; GO:0036503; GO:0048488; GO:0072583; GO:0098793
GN007386	GN007386.1	O43301	30.6	366	356	675	6.77e-47	172	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN007387	GN007387.1	Q96MM6	35.5	166	180	686	4.04e-20	90.1	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN007388	GN007388.1	Q9CZJ2	29.8	635	1520	685	1.69e-62	231	HS12B_MOUSE	Heat shock 70 kDa protein 12B	Mus musculus (Mouse)	angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]			GO:0001525; GO:0043542
GN007389	GN007389.1	Q8K0U4	30.4	628	1444	675	2.10e-77	274	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007390	GN007390.1	Q8K0U4	29.7	623	1402	675	3.26e-61	226	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007391	GN007391.1	Q460N5	25.3	396	760	1801	2.92e-26	119	PAR14_HUMAN	Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14)	Homo sapiens (Human)	NAD+ catabolic process [GO:0019677]; negative regulation of gene expression [GO:0010629]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein poly-ADP-ribosylation [GO:0070212]	enzyme binding [GO:0019899]; NAD+ binding [GO:0070403]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0003714; GO:0003950; GO:0005634; GO:0005737; GO:0005829; GO:0010629; GO:0016020; GO:0019677; GO:0019899; GO:0042531; GO:0042532; GO:0060336; GO:0070212; GO:0070403; GO:0140807; GO:1902216; GO:1990404
GN007392	GN007392.1	P60322	53.4	73	156	136	4.24e-21	86.3	NANO2_MOUSE	Nanos homolog 2 (NOS-2)	Mus musculus (Mouse)	germ-line stem cell population maintenance [GO:0030718]; mRNA catabolic process [GO:0006402]; mRNA destabilization [GO:0061157]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of translation [GO:0017148]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]	enzyme activator activity [GO:0008047]; mRNA binding [GO:0003729]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]	GO:0000932; GO:0003729; GO:0005634; GO:0005737; GO:0006402; GO:0007283; GO:0008047; GO:0008270; GO:0017148; GO:0030718; GO:0045835; GO:0048471; GO:0048477; GO:0061157
GN007393	GN007393.1	Q5ZMW5	50.8	583	736	760	2.36e-182	541	RHG26_CHICK	Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (Rho-type GTPase-activating protein 26)	Gallus gallus (Chicken)	mitophagy [GO:0000423]; signal transduction [GO:0007165]	GTPase activator activity [GO:0005096]; phospholipid binding [GO:0005543]; protein-macromolecule adaptor activity [GO:0030674]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]	GO:0000423; GO:0005096; GO:0005543; GO:0005739; GO:0005829; GO:0005856; GO:0005925; GO:0007165; GO:0010008; GO:0030674
GN007394	GN007394.1	Q6X1Y6	26.2	397	386	530	1.95e-28	119	ASIC3_MOUSE	Acid-sensing ion channel 3 (ASIC3) (Amiloride-sensitive cation channel 3) (Dorsal root ASIC) (DRASIC)	Mus musculus (Mouse)	detection of chemical stimulus involved in sensory perception [GO:0050907]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception [GO:0050961]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; membrane depolarization [GO:0051899]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; response to acidic pH [GO:0010447]; response to heat [GO:0009408]; response to mechanical stimulus [GO:0009612]; sensory perception of sour taste [GO:0050915]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]	ligand-gated sodium channel activity [GO:0015280]; monoatomic cation channel activity [GO:0005261]; monoatomic ion-gated channel activity [GO:0022839]; pH-gated calcium channel activity [GO:0160126]; pH-gated monoatomic ion channel activity [GO:0160128]; pH-gated sodium channel activity [GO:0160125]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0005261; GO:0005737; GO:0005886; GO:0006812; GO:0006814; GO:0009408; GO:0009612; GO:0010447; GO:0015280; GO:0022839; GO:0034220; GO:0035725; GO:0048471; GO:0050907; GO:0050915; GO:0050961; GO:0050965; GO:0050966; GO:0050968; GO:0050974; GO:0051899; GO:0160125; GO:0160126; GO:0160128
GN007396	GN007396.1	Q80WQ4	60.3	156	694	447	4.44e-60	211	TRM9B_MOUSE	Probable tRNA methyltransferase 9B (Probable tRNA methyltransferase 9-like protein) (EC 2.1.1.-)	Mus musculus (Mouse)	tRNA methylation [GO:0030488]	S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity [GO:0106335]; tRNA binding [GO:0000049]; tRNA methyltransferase activity [GO:0008175]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000049; GO:0005634; GO:0005737; GO:0008175; GO:0008757; GO:0030488; GO:0106335
GN007401	GN007401.1	Q9BRZ2	28.5	221	706	755	5.69e-17	89.0	TRI56_HUMAN	E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56)	Homo sapiens (Human)	defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340]	RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0003723; GO:0004842; GO:0005654; GO:0005737; GO:0005829; GO:0006513; GO:0008270; GO:0032479; GO:0032728; GO:0034340; GO:0045087; GO:0045089; GO:0051607; GO:0060340; GO:0061630; GO:0070534; GO:1901224
GN007402	GN007402.1	Q9R1X5	38.2	1432	1446	1436	1.33e-311	922	MRP5_MOUSE	ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP)	Mus musculus (Mouse)	cAMP transport [GO:0070730]; cGMP transport [GO:0070731]; export across plasma membrane [GO:0140115]; folate transmembrane transport [GO:0098838]; glutathione transmembrane transport [GO:0034775]; heme transmembrane transport [GO:0035351]; hyaluronan biosynthetic process [GO:0030213]; purine nucleotide transport [GO:0015865]; xenobiotic transport [GO:0042908]	ABC-type 3',5'-cyclic GMP transmembrane transporter activity [GO:1905948]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; heme transmembrane transporter activity [GO:0015232]; purine nucleotide transmembrane transporter activity [GO:0015216]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endosome membrane [GO:0010008]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0005524; GO:0005796; GO:0005886; GO:0008559; GO:0010008; GO:0015216; GO:0015232; GO:0015562; GO:0015865; GO:0016020; GO:0016323; GO:0016324; GO:0016887; GO:0030213; GO:0034634; GO:0034775; GO:0035351; GO:0042908; GO:0042910; GO:0048471; GO:0070730; GO:0070731; GO:0098838; GO:0140115; GO:0140359; GO:1905948
GN007403	GN007403.1	Q60997	22.5	383	667	2085	4.73e-10	67.0	DMBT1_MOUSE	Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Apactin) (CRP-ductin) (Deleted in malignant brain tumors 1 protein) (Glycoprotein 300) (gp300) (Hensin) (Mucin-like glycoprotein) (Muclin) (Vomeroglandin) (p80)	Mus musculus (Mouse)	antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; blastocyst development [GO:0001824]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; induction of bacterial agglutination [GO:0043152]; inner cell mass cell proliferation [GO:0001833]; positive regulation of epithelial cell differentiation [GO:0030858]; receptor-mediated endocytosis [GO:0006898]; response to bacterium [GO:0009617]	DNA binding [GO:0003677]; heparan sulfate binding [GO:1904399]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]; phagocytic vesicle membrane [GO:0030670]; transport vesicle membrane [GO:0030658]; zymogen granule membrane [GO:0042589]	GO:0001530; GO:0001824; GO:0001833; GO:0003677; GO:0005044; GO:0005576; GO:0005737; GO:0006898; GO:0009617; GO:0030658; GO:0030670; GO:0030858; GO:0031012; GO:0035375; GO:0038187; GO:0042589; GO:0043152; GO:0050829; GO:0050830; GO:0061844; GO:0070891; GO:0140144; GO:1904399
GN007404	GN007404.1	P34586	55.9	297	299	1027	2.36e-102	324	TRPL_CAEEL	Transient-receptor-potential-like protein (TRP homologous cation channel protein 1)	Caenorhabditis elegans	calcium ion transmembrane transport [GO:0070588]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338]	inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]	cation channel complex [GO:0034703]; plasma membrane [GO:0005886]	GO:0005886; GO:0007338; GO:0015279; GO:0034703; GO:0051480; GO:0070588; GO:0070679
GN007405	GN007405.1	P79797	30.4	204	379	322	4.35e-10	63.9	TF3A_ICTPU	Transcription factor IIIA (TFIIIA)	Ictalurus punctatus (Channel catfish) (Silurus punctatus)	positive regulation of DNA-templated transcription [GO:0045893]; ribosomal large subunit biogenesis [GO:0042273]		nucleus [GO:0005634]	GO:0005634; GO:0042273; GO:0045893
GN007406	GN007406.1	Q5F457	32.9	149	278	398	3.41e-09	60.5	WBP4_CHICK	WW domain-binding protein 4 (WBP-4)	Gallus gallus (Chicken)	mRNA splicing, via spliceosome [GO:0000398]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]	GO:0000398; GO:0003676; GO:0005634; GO:0008270; GO:0016607; GO:0071005
GN007407	GN007407.1	Q32N90	53.0	581	864	621	2.40e-210	613	MBTD1_XENLA	MBT domain-containing protein 1	Xenopus laevis (African clawed frog)	double-strand break repair via homologous recombination [GO:0000724]; negative regulation of DNA-templated transcription [GO:0045892]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H4K20me2 reader activity [GO:0140005]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleus [GO:0005634]	GO:0000724; GO:0003682; GO:0005634; GO:0005694; GO:0008270; GO:0035267; GO:0042393; GO:0045892; GO:0140005
GN007409	GN007409.1	P54729	34.8	647	614	614	3.20e-100	320	NUB1_MOUSE	NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Protein BS4)	Mus musculus (Mouse)	positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; ubiquitin-dependent protein catabolic process [GO:0006511]		cytosol [GO:0005829]; Lewy body [GO:0097413]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0006511; GO:0010498; GO:0016567; GO:0032436; GO:0034341; GO:0034612; GO:0097413; GO:2000058
GN007410	GN007410.1	Q7Z0T3	51.0	104	574	125	1.75e-27	110	TEMPT_APLCA	Temptin	Aplysia californica (California sea hare)			extracellular region [GO:0005576]	GO:0005576
GN007413	GN007413.1	Q5SS90	31.8	223	357	291	8.97e-22	97.1	CG057_MOUSE	Uncharacterized protein C7orf57 homolog	Mus musculus (Mouse)				
GN007414	GN007414.1	Q5BLD8	50.2	217	216	218	1.48e-66	207	MT21A_DANRE	Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (Methyltransferase-like protein 21A)	Danio rerio (Zebrafish) (Brachydanio rerio)		protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]	GO:0005737; GO:0005829; GO:0016279; GO:0032991
GN007415	GN007415.1	Q5ZHV5	56.4	314	397	425	7.75e-138	403	JMJD4_CHICK	2-oxoglutarate and iron-dependent oxygenase JMJD4 (EC 1.14.11.-) (JmjC domain-containing protein 4) (Jumonji domain-containing protein 4) (Lysyl-hydroxylase JMJD4)	Gallus gallus (Chicken)	positive regulation of translational termination [GO:0045905]; protein hydroxylation [GO:0018126]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; peptidyl-lysine 4-dioxygenase activity [GO:0106156]	cytoplasm [GO:0005737]	GO:0005737; GO:0016706; GO:0018126; GO:0045905; GO:0106156
GN007416	GN007416.1	Q15042	47.1	940	924	981	1.79e-285	820	RB3GP_HUMAN	Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP)	Homo sapiens (Human)	brain development [GO:0007420]; camera-type eye development [GO:0043010]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; excitatory postsynaptic potential [GO:0060079]; face morphogenesis [GO:0060325]; hypothalamus development [GO:0021854]; lipid droplet organization [GO:0034389]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of protein lipidation [GO:1903061]; Rab protein signal transduction [GO:0032482]; regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903233]; regulation of short-term neuronal synaptic plasticity [GO:0048172]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; GTPase complex [GO:1905360]; lipid droplet [GO:0005811]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]	GO:0005085; GO:0005096; GO:0005737; GO:0005783; GO:0005789; GO:0005794; GO:0005801; GO:0005811; GO:0005829; GO:0007420; GO:0021854; GO:0031267; GO:0032482; GO:0032991; GO:0034389; GO:0043010; GO:0048172; GO:0060079; GO:0060325; GO:0061646; GO:0070062; GO:0071782; GO:0097051; GO:0098794; GO:1903061; GO:1903233; GO:1903373; GO:1905360; GO:2000786
GN007420	GN007420.1	Q86WI1	30.8	480	500	4243	5.70e-46	176	PKHL1_HUMAN	Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1)	Homo sapiens (Human)	immune response [GO:0006955]	signaling receptor activity [GO:0038023]	cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; stereocilium coat [GO:0120234]; stereocilium membrane [GO:0060171]; stereocilium tip [GO:0032426]	GO:0005576; GO:0005829; GO:0006955; GO:0016020; GO:0032426; GO:0038023; GO:0060171; GO:0120234
GN007433	GN007433.1	Q96HV5	38.5	247	189	264	3.73e-43	147	TM41A_HUMAN	Transmembrane protein 41A	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN007434	GN007434.1	Q6GQB9	50.0	390	646	913	4.69e-107	347	EDEM3_XENLA	ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)	Xenopus laevis (African clawed frog)	carbohydrate metabolic process [GO:0005975]; endoplasmic reticulum mannose trimming [GO:1904380]; endoplasmic reticulum unfolded protein response [GO:0030968]; ubiquitin-dependent glycoprotein ERAD pathway [GO:0097466]	calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020]	GO:0004571; GO:0005509; GO:0005788; GO:0005975; GO:0016020; GO:0030968; GO:0044322; GO:0097466; GO:1904380
GN007440	GN007440.1	Q5ZLF0	40.7	403	422	361	2.33e-49	174	F10A1_CHICK	Hsc70-interacting protein (Hip) (Protein FAM10A1) (Protein ST13 homolog)	Gallus gallus (Chicken)	protein folding [GO:0006457]	Hsp70 protein binding [GO:0030544]; protein dimerization activity [GO:0046983]	cytoplasm [GO:0005737]	GO:0005737; GO:0006457; GO:0030544; GO:0046983
GN007442	GN007442.1	B5DEQ3	35.0	446	1103	506	8.91e-76	262	XPP3_RAT	Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3)	Rattus norvegicus (Rat)	glomerular filtration [GO:0003094]; protein processing [GO:0016485]; proteolysis [GO:0006508]	aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0003094; GO:0004177; GO:0005737; GO:0005739; GO:0005829; GO:0006508; GO:0016485; GO:0030145; GO:0042803; GO:0070006
GN007443	GN007443.1	Q5ZLM0	62.1	380	403	531	8.84e-141	414	CDC73_CHICK	Parafibromin (Cell division cycle protein 73 homolog)	Gallus gallus (Chicken)	endodermal cell fate commitment [GO:0001711]; mRNA 3'-end processing [GO:0031124]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of Wnt signaling pathway [GO:0030177]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]	RNA polymerase II complex binding [GO:0000993]	Cdc73/Paf1 complex [GO:0016593]; nucleus [GO:0005634]	GO:0000122; GO:0000993; GO:0001711; GO:0005634; GO:0006368; GO:0008285; GO:0016593; GO:0019827; GO:0030177; GO:0031124; GO:0031442; GO:0032968; GO:0045638; GO:1902808; GO:2000134
GN007444	GN007444.1	O95336	50.5	186	201	258	2.54e-62	197	6PGL_HUMAN	6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]	6-phosphogluconolactonase activity [GO:0017057]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005829; GO:0005975; GO:0006098; GO:0009051; GO:0017057; GO:0070062
GN007445	GN007445.1	P50613	66.6	338	336	346	7.58e-164	463	CDK7_HUMAN	Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)	Homo sapiens (Human)	nucleotide-excision repair [GO:0006289]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II CTD heptapeptide repeat kinase activity [GO:0008353]; RNA polymerase II CTD heptapeptide repeat S5 kinase activity [GO:0140836]	CAK-ERCC2 complex [GO:0070516]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription factor TFIIK complex [GO:0070985]	GO:0000307; GO:0000439; GO:0001650; GO:0004672; GO:0004674; GO:0004693; GO:0005524; GO:0005634; GO:0005654; GO:0005675; GO:0005737; GO:0005829; GO:0006289; GO:0006366; GO:0006367; GO:0008094; GO:0008353; GO:0042795; GO:0045944; GO:0048471; GO:0050821; GO:0051726; GO:0070516; GO:0070985; GO:0106310; GO:0140836; GO:2000045
GN007447	GN007447.1	Q9P0M2	33.5	200	219	348	1.71e-23	99.4	AKA7G_HUMAN	A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma)	Homo sapiens (Human)	modulation of chemical synaptic transmission [GO:0050804]	protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0005634; GO:0005737; GO:0005829; GO:0019901; GO:0032991; GO:0034237; GO:0050804; GO:0051018; GO:0098686
GN007451	GN007451.1	Q5HZL5	29.6	206	268	377	5.04e-29	116	B3G5A_XENLA	Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A (EC 2.4.1.206) (Lactotriaosylceramide synthase A) (Lc(3)Cer synthase A) (Lc3 synthase A) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5A) (BGnT-5A) (Beta-1,3-Gn-T5A) (Beta-1,3-N-acetylglucosaminyltransferase 5A) (Beta3Gn-T5A)	Xenopus laevis (African clawed frog)	protein O-linked glycosylation [GO:0006493]; sphingolipid biosynthetic process [GO:0030148]	lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity [GO:0047256]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006493; GO:0030148; GO:0047256
GN007452	GN007452.1	O61491	70.1	164	189	426	2.34e-75	235	FLOT1_DROME	Flotillin-1	Drosophila melanogaster (Fruit fly)	positive regulation of endocytosis [GO:0045807]; protein localization to plasma membrane [GO:0072659]; regulation of receptor internalization [GO:0002090]	protease binding [GO:0002020]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; flotillin complex [GO:0016600]	GO:0002020; GO:0002090; GO:0005198; GO:0005737; GO:0016600; GO:0031410; GO:0045807; GO:0072659
GN007453	GN007453.1	O61491	52.9	257	261	426	1.04e-39	145	FLOT1_DROME	Flotillin-1	Drosophila melanogaster (Fruit fly)	positive regulation of endocytosis [GO:0045807]; protein localization to plasma membrane [GO:0072659]; regulation of receptor internalization [GO:0002090]	protease binding [GO:0002020]; structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; flotillin complex [GO:0016600]	GO:0002020; GO:0002090; GO:0005198; GO:0005737; GO:0016600; GO:0031410; GO:0045807; GO:0072659
GN007454	GN007454.1	Q58DL5	30.3	770	886	826	4.78e-93	315	BCAR3_BOVIN	Breast cancer anti-estrogen resistance protein 3 homolog	Bos taurus (Bovine)	endothelin receptor signaling pathway [GO:0086100]; epidermal growth factor receptor signaling pathway [GO:0007173]; insulin receptor signaling pathway [GO:0008286]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAPK cascade [GO:0043410]; small GTPase-mediated signal transduction [GO:0007264]	guanyl-nucleotide exchange factor activity [GO:0005085]; phosphotyrosine residue binding [GO:0001784]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; membrane [GO:0016020]	GO:0001784; GO:0005085; GO:0005737; GO:0005925; GO:0007173; GO:0007264; GO:0008284; GO:0008286; GO:0016020; GO:0043410; GO:0043547; GO:0086100
GN007455	GN007455.1	Q9Y113	56.4	576	568	594	1.13e-228	647	NELFB_DROME	Negative elongation factor B	Drosophila melanogaster (Fruit fly)	negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of transcription by RNA polymerase II [GO:0045944]	RNA binding [GO:0003723]	chromosome [GO:0005694]; NELF complex [GO:0032021]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	GO:0000122; GO:0003723; GO:0005634; GO:0005694; GO:0017053; GO:0032021; GO:0034244; GO:0045944
GN007459	GN007459.1	Q704S8	43.1	72	115	626	7.66e-13	66.6	CACP_RAT	Carnitine O-acetyltransferase (Carnitine acetylase) (EC 2.3.1.137) (EC 2.3.1.7) (Carnitine acetyltransferase) (CAT) (CrAT)	Rattus norvegicus (Rat)	carnitine metabolic process, CoA-linked [GO:0019254]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid metabolic process [GO:0006631]; medium-chain fatty acid metabolic process [GO:0051791]; short-chain fatty acid metabolic process [GO:0046459]	acyl-CoA oxidase activity [GO:0003997]; carnitine O-acetyltransferase activity [GO:0004092]; carnitine O-octanoyltransferase activity [GO:0008458]	endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]	GO:0003997; GO:0004092; GO:0005739; GO:0005743; GO:0005777; GO:0005783; GO:0006631; GO:0008458; GO:0019254; GO:0033540; GO:0046459; GO:0051791
GN007460	GN007460.1	P52826	50.9	466	465	627	1.47e-166	486	CACP_COLLI	Carnitine O-acetyltransferase (Carnitine acetylase) (EC 2.3.1.137) (EC 2.3.1.7) (Carnitine acetyltransferase) (CAT) (CrAT)	Columba livia (Rock dove)	carnitine metabolic process, CoA-linked [GO:0019254]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; medium-chain fatty acid metabolic process [GO:0051791]; short-chain fatty acid metabolic process [GO:0046459]	acyl-CoA oxidase activity [GO:0003997]; carnitine O-acetyltransferase activity [GO:0004092]; carnitine O-octanoyltransferase activity [GO:0008458]	endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; peroxisome [GO:0005777]	GO:0003997; GO:0004092; GO:0005743; GO:0005777; GO:0005783; GO:0008458; GO:0019254; GO:0033540; GO:0046459; GO:0051791
GN007461	GN007461.1	Q5U3U0	51.3	240	239	291	3.03e-76	235	PHYD1_DANRE	Phytanoyl-CoA dioxygenase domain-containing protein 1 (Protein PHYHD1) (EC 1.14.11.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	oxidative RNA demethylation [GO:0035513]			GO:0035513
GN007464	GN007464.1	Q9IA76	71.3	115	141	124	2.90e-55	172	RL31_PAROL	Large ribosomal subunit protein eL31 (60S ribosomal protein L31)	Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus)	cytoplasmic translation [GO:0002181]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]	GO:0002181; GO:0003735; GO:0005737; GO:0022625
GN007467	GN007467.1	O43301	35.0	626	582	675	9.81e-115	359	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN007468	GN007468.1	Q8K0U4	35.4	390	352	675	2.32e-67	227	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007469	GN007469.1	P42263	42.8	789	858	894	5.50e-200	596	GRIA3_HUMAN	Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3)	Homo sapiens (Human)	glutamate receptor signaling pathway [GO:0007215]; long-term synaptic potentiation [GO:0060291]; modulation of chemical synaptic transmission [GO:0050804]; protein heterotetramerization [GO:0051290]; protein homotetramerization [GO:0051289]; synaptic transmission, glutamatergic [GO:0035249]	AMPA glutamate receptor activity [GO:0004971]; amyloid-beta binding [GO:0001540]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	AMPA glutamate receptor complex [GO:0032281]; dendritic spine [GO:0043197]; endocytic vesicle membrane [GO:0030666]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]	GO:0001540; GO:0004970; GO:0004971; GO:0005886; GO:0007215; GO:0022849; GO:0030666; GO:0032281; GO:0035249; GO:0043197; GO:0045211; GO:0050804; GO:0051289; GO:0051290; GO:0060291; GO:0098839; GO:0099507; GO:1904315
GN007470	GN007470.1	P14099	61.7	501	1438	921	3.69e-213	649	PDE2A_BOVIN	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)	Bos taurus (Bovine)	cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to mechanical stimulus [GO:0071260]; cGMP catabolic process [GO:0046069]; establishment of endothelial barrier [GO:0061028]; GMP catabolic process [GO:0046038]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of cAMP/PKA signal transduction [GO:0141162]; negative regulation of receptor guanylyl cyclase signaling pathway [GO:0010754]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of vascular permeability [GO:0043117]; regulation of mitochondrion organization [GO:0010821]; signal transduction [GO:0007165]	3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cGMP binding [GO:0030553]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]	GO:0000122; GO:0004114; GO:0004115; GO:0004118; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0007165; GO:0010628; GO:0010754; GO:0010821; GO:0030553; GO:0036006; GO:0042734; GO:0042803; GO:0043116; GO:0043117; GO:0046038; GO:0046069; GO:0047555; GO:0048471; GO:0050729; GO:0061028; GO:0071260; GO:0071321; GO:0097011; GO:0097060; GO:0106072; GO:0141162
GN007471	GN007471.1	A6Q9N6	31.9	382	385	359	4.62e-43	156	ANMK_SULNB	Anhydro-N-acetylmuramic acid kinase (EC 2.7.1.170) (AnhMurNAc kinase)	Sulfurovum sp. (strain NBC37-1)	1,6-anhydro-N-acetyl-beta-muramic acid catabolic process [GO:0097175]; amino sugar metabolic process [GO:0006040]; peptidoglycan turnover [GO:0009254]	ATP binding [GO:0005524]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]		GO:0005524; GO:0006040; GO:0009254; GO:0016773; GO:0097175
GN007472	GN007472.1	Q7JK24	30.5	213	373	326	1.04e-26	111	B3GT1_GORGO	Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)	Gorilla gorilla gorilla (Western lowland gorilla)	glucosylceramide metabolic process [GO:0006678]; glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006678; GO:0008499; GO:0009101; GO:0009312
GN007473	GN007473.1	Q6NTV6	37.6	1054	1305	1099	1.66e-139	457	INF2_XENLA	Inverted formin-2	Xenopus laevis (African clawed frog)	actin cytoskeleton organization [GO:0030036]	actin binding [GO:0003779]; small GTPase binding [GO:0031267]		GO:0003779; GO:0030036; GO:0031267
GN007475	GN007475.1	Q9QZD5	38.8	647	702	621	6.38e-127	393	RAE2_MOUSE	Rab proteins geranylgeranyltransferase component A 2 (Choroideremia-like protein) (Rab escort protein 2) (REP-2)	Mus musculus (Mouse)	intracellular protein transport [GO:0006886]; protein geranylgeranylation [GO:0018344]; protein targeting to membrane [GO:0006612]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]	GDP-dissociation inhibitor activity [GO:0005092]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rab-protein geranylgeranyltransferase complex [GO:0005968]	GO:0005092; GO:0005634; GO:0005654; GO:0005829; GO:0005968; GO:0006612; GO:0006886; GO:0007264; GO:0016192; GO:0018344; GO:0031267
GN007476	GN007476.1	Q5F361	55.8	901	892	893	0.0	957	TBCK_CHICK	TBC domain-containing protein kinase-like protein (FERRY endosomal RAB5 effector complex subunit 1)	Gallus gallus (Chicken)		ATP binding [GO:0005524]; GTPase activator activity [GO:0005096]; protein kinase activity [GO:0004672]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; midbody [GO:0030496]; spindle [GO:0005819]	GO:0004672; GO:0005096; GO:0005524; GO:0005737; GO:0005769; GO:0005819; GO:0030496
GN007477	GN007477.1	P30919	58.1	265	279	345	1.82e-98	295	ASPG_RAT	N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (AGA) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain]	Rattus norvegicus (Rat)	protein deglycosylation [GO:0006517]	identical protein binding [GO:0042802]; N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity [GO:0003948]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0003948; GO:0005576; GO:0005737; GO:0005764; GO:0005783; GO:0006517; GO:0042802
GN007479	GN007479.1	O01346	50.3	306	328	457	3.50e-104	315	EGH_DROME	Glycolipid beta-1,4-mannosyltransferase egh (EC 2.4.1.-) (GDP-Man:beta-Glc beta1,4-Mannosyl transferase) (Protein egghead) (Protein zeste-white 4)	Drosophila melanogaster (Fruit fly)	arthro-series glucosylceramide biosynthetic process [GO:0140269]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell fate commitment [GO:0045165]; follicle cell of egg chamber development [GO:0030707]; follicle cell of egg chamber-cell adhesion [GO:0007299]; germ cell development [GO:0007281]; germarium-derived egg chamber formation [GO:0007293]; insect visual primordium formation [GO:0001744]; maintenance of polarity of follicular epithelium [GO:0042248]; male courtship behavior [GO:0008049]; morphogenesis of follicular epithelium [GO:0016333]; negative regulation of female receptivity, post-mating [GO:0045434]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oocyte microtubule cytoskeleton organization [GO:0016325]; peripheral nervous system neuron development [GO:0048935]; regulation of egg-laying behavior [GO:0046662]	beta-1,4-mannosyltransferase activity [GO:0019187]	cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0001744; GO:0005737; GO:0007281; GO:0007293; GO:0007298; GO:0007299; GO:0007411; GO:0008049; GO:0016020; GO:0016325; GO:0016333; GO:0019187; GO:0030707; GO:0030720; GO:0042248; GO:0045165; GO:0045434; GO:0046662; GO:0048935; GO:0140269
GN007480	GN007480.1	Q7T2C4	37.5	696	807	739	9.47e-128	402	S26A5_DANRE	Prestin (Solute carrier family 26 member 5)	Danio rerio (Zebrafish) (Brachydanio rerio)	chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; oxalate transport [GO:0019532]; regulation of membrane potential [GO:0042391]; sulfate transmembrane transport [GO:1902358]	chloride:bicarbonate antiporter activity [GO:0140900]; formate transmembrane transporter activity [GO:0015499]; monoatomic ion transmembrane transporter activity [GO:0015075]; oxalate transmembrane transporter activity [GO:0019531]; oxalate:chloride antiporter activity [GO:0160046]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:chloride antiporter activity [GO:0160044]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0006821; GO:0008271; GO:0015075; GO:0015116; GO:0015499; GO:0016020; GO:0019531; GO:0019532; GO:0042391; GO:0140900; GO:0160044; GO:0160046; GO:1902358; GO:1902476
GN007483	GN007483.1	P86862	53.0	66	491	65	3.43e-16	76.3	VKT1_ANTEL	KappaPI-actitoxin-Ael3a (KappaPI-AITX-Ael3a) (Kunitz-type serine protease inhibitor APEKTx1)	Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)		potassium channel inhibitor activity [GO:0019870]; serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; nematocyst [GO:0042151]	GO:0004867; GO:0005576; GO:0019870; GO:0042151
GN007484	GN007484.1	B3EWZ6	35.6	180	511	7311	5.06e-22	104	MLRP2_ACRMI	MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN007485	GN007485.1	B3EWZ5	30.6	193	528	5145	2.44e-16	86.7	MLRP1_ACRMI	MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN007487	GN007487.1	P51521	71.6	141	736	1351	1.75e-26	120	OVO_DROME	Transcriptional regulator ovo (Transcriptional repressor shavenbaby) (Transcriptional repressor svb) [Cleaved into: Transcriptional activator shavenbaby (Transcriptional activator svb)]	Drosophila melanogaster (Fruit fly)	adult feeding behavior [GO:0008343]; cuticle pattern formation [GO:0035017]; cuticle pigmentation [GO:0048067]; cytoskeleton organization [GO:0007010]; epidermal cell differentiation [GO:0009913]; germ-line sex determination [GO:0018992]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; non-sensory hair organization [GO:0035316]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357]; transposition [GO:0032196]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0001223; GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0007010; GO:0008343; GO:0008360; GO:0009913; GO:0016348; GO:0018992; GO:0032196; GO:0035017; GO:0035316; GO:0043565; GO:0045892; GO:0045893; GO:0045944; GO:0048067; GO:1990837
GN007489	GN007489.1	Q8K2Y0	43.0	242	1173	722	2.90e-49	191	OBI1_MOUSE	ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219)	Mus musculus (Mouse)	positive regulation of mRNA splicing, via spliceosome [GO:0048026]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; regulation of DNA replication [GO:0006275]	chromatin binding [GO:0003682]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	chromatin [GO:0000785]; chromosome [GO:0005694]	GO:0000785; GO:0003682; GO:0004842; GO:0005694; GO:0006275; GO:0006513; GO:0048026; GO:0051865; GO:0061630
GN007490	GN007490.1	Q5T8P6	29.8	813	854	1007	2.73e-61	228	RBM26_HUMAN	RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26)	Homo sapiens (Human)	RNA catabolic process [GO:0006401]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005654; GO:0006401; GO:0046872
GN007491	GN007491.1	Q5T8P6	42.2	109	211	1007	2.23e-16	80.5	RBM26_HUMAN	RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26)	Homo sapiens (Human)	RNA catabolic process [GO:0006401]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005654; GO:0006401; GO:0046872
GN007501	GN007501.1	P17972	27.9	383	435	498	2.89e-42	159	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN007503	GN007503.1	Q9H0W7	31.9	144	230	228	7.12e-10	60.5	THAP2_HUMAN	THAP domain-containing protein 2	Homo sapiens (Human)			nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730
GN007504	GN007504.1	P98164	24.6	912	1071	4655	4.27e-45	182	LRP2_HUMAN	Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)	Homo sapiens (Human)	amyloid-beta clearance [GO:0097242]; cellular response to growth factor stimulus [GO:0071363]; cobalamin transport [GO:0015889]; coronary artery morphogenesis [GO:0060982]; endocytosis [GO:0006897]; folate import across plasma membrane [GO:1904447]; lipid metabolic process [GO:0006629]; male gonad development [GO:0008584]; metal ion transport [GO:0030001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; neural tube closure [GO:0001843]; neuron projection arborization [GO:0140058]; outflow tract septum morphogenesis [GO:0003148]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of neurogenesis [GO:0050769]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; protein transport [GO:0015031]; pulmonary artery morphogenesis [GO:0061156]; receptor-mediated endocytosis [GO:0006898]; response to leptin [GO:0044321]; retinoid metabolic process [GO:0001523]; secondary heart field specification [GO:0003139]; sensory perception of sound [GO:0007605]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]; vagina development [GO:0060068]; ventricular compact myocardium morphogenesis [GO:0003223]; vitamin D metabolic process [GO:0042359]	calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; hormone binding [GO:0042562]; insulin-like growth factor I binding [GO:0031994]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-folding chaperone binding [GO:0051087]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; brush border membrane [GO:0031526]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001523; GO:0001843; GO:0003139; GO:0003148; GO:0003223; GO:0005041; GO:0005509; GO:0005764; GO:0005765; GO:0005783; GO:0005794; GO:0005886; GO:0005905; GO:0006629; GO:0006897; GO:0006898; GO:0007605; GO:0008584; GO:0009897; GO:0015031; GO:0015889; GO:0016324; GO:0030001; GO:0030424; GO:0030425; GO:0030514; GO:0030669; GO:0031526; GO:0031904; GO:0031994; GO:0038024; GO:0042359; GO:0042562; GO:0043066; GO:0043235; GO:0043491; GO:0044321; GO:0045056; GO:0050769; GO:0051087; GO:0060068; GO:0060982; GO:0061156; GO:0070062; GO:0070447; GO:0071363; GO:0097242; GO:0140058; GO:0150104; GO:1904447; GO:1905167
GN007506	GN007506.1	Q8NFW1	32.8	259	510	1626	2.35e-25	114	COMA1_HUMAN	Collagen alpha-1(XXII) chain	Homo sapiens (Human)	extracellular matrix organization [GO:0030198]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	basement membrane [GO:0005604]; collagen type XXII trimer [GO:1990321]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]	GO:0005576; GO:0005604; GO:0005788; GO:0030020; GO:0030198; GO:1990321
GN007508	GN007508.1	Q7WHJ0	26.7	258	279	308	5.14e-13	71.2	ECTD_BORBR	Ectoine dioxygenase (EC 1.14.11.55) (Ectoine hydroxylase)	Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)	ectoine catabolic process [GO:0042400]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506]		GO:0005506; GO:0016706; GO:0042400
GN007509	GN007509.1	O14082	35.2	383	376	406	3.13e-70	228	YEAH_SCHPO	Uncharacterized protein UNK4.17	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)		nucleotide binding [GO:0000166]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000166; GO:0005634; GO:0005829; GO:0016616
GN007510	GN007510.1	Q5EA50	47.5	219	415	372	7.09e-71	230	RABEK_BOVIN	Rab9 effector protein with kelch motifs	Bos taurus (Bovine)			cytoplasm [GO:0005737]; endosome membrane [GO:0010008]	GO:0005737; GO:0010008
GN007511	GN007511.1	O43543	35.3	295	293	280	1.99e-49	168	XRCC2_HUMAN	DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2)	Homo sapiens (Human)	centrosome cycle [GO:0007098]; DNA repair [GO:0006281]; DNA strand invasion [GO:0042148]; double-strand break repair via homologous recombination [GO:0000724]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; supramolecular fiber organization [GO:0097435]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]	centrosome [GO:0005813]; nucleoplasm [GO:0005654]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]	GO:0000278; GO:0000724; GO:0003677; GO:0005524; GO:0005654; GO:0005657; GO:0005813; GO:0006281; GO:0007098; GO:0033063; GO:0042148; GO:0051321; GO:0097435; GO:0140664
GN007512	GN007512.1	Q28CB1	38.5	122	214	943	3.98e-25	105	TBD2B_XENTR	TBC1 domain family member 2B	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; early endosome [GO:0005769]	GO:0005096; GO:0005769; GO:0005829; GO:0031267
GN007513	GN007513.1	Q5M8C6	44.4	225	751	314	3.09e-45	167	FGL1_RAT	Fibrinogen-like protein 1	Rattus norvegicus (Rat)	adipose tissue development [GO:0060612]; blood coagulation [GO:0007596]; cholesterol metabolic process [GO:0008203]; hepatocyte proliferation [GO:0072574]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; regulation of glucose metabolic process [GO:0010906]; regulation of immune response [GO:0050776]; response to stilbenoid [GO:0035634]	identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005576; GO:0005886; GO:0007596; GO:0008203; GO:0010906; GO:0031012; GO:0035634; GO:0042802; GO:0048018; GO:0050776; GO:0050860; GO:0050868; GO:0060612; GO:0072574
GN007514	GN007514.1	Q9UPU7	41.1	90	1103	963	3.16e-11	71.6	TBD2B_HUMAN	TBC1 domain family member 2B	Homo sapiens (Human)	endocytosis [GO:0006897]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; plasma membrane [GO:0005886]	GO:0005096; GO:0005737; GO:0005769; GO:0005829; GO:0005886; GO:0006897
GN007515	GN007515.1	Q503M4	26.6	492	629	477	3.86e-46	173	MT12B_DANRE	Monocarboxylate transporter 12-B (MCT 12-B) (Solute carrier family 16 member 12-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; transmembrane transporter activity [GO:0022857]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0022857; GO:0046449
GN007516	GN007516.1	A5PK45	46.8	560	602	623	1.19e-180	527	GT251_BOVIN	Procollagen galactosyltransferase 1 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1)	Bos taurus (Bovine)	positive regulation of collagen fibril organization [GO:1904028]; protein O-linked glycosylation via galactose [GO:0180062]	procollagen galactosyltransferase activity [GO:0050211]	endoplasmic reticulum lumen [GO:0005788]	GO:0005788; GO:0050211; GO:0180062; GO:1904028
GN007517	GN007517.1	B5X601	48.6	72	108	138	2.91e-17	74.7	SWI5_SALSA	DNA repair protein SWI5 homolog (Protein SAE3 homolog)	Salmo salar (Atlantic salmon)	double-strand break repair via homologous recombination [GO:0000724]		nucleus [GO:0005634]; Swi5-Sfr1 complex [GO:0032798]; Swi5-Swi2 complex [GO:0034974]	GO:0000724; GO:0005634; GO:0032798; GO:0034974
GN007519	GN007519.1	Q8BLN6	34.1	3074	3421	3326	0.0	1454	UNC80_MOUSE	Protein unc-80 homolog (mUNC-80)	Mus musculus (Mouse)	monoatomic cation homeostasis [GO:0055080]; regulation of neuronal action potential [GO:0098908]; sodium ion transmembrane transport [GO:0035725]	monoatomic cation channel activity [GO:0005261]	axon [GO:0030424]; cation channel complex [GO:0034703]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]; voltage-gated sodium channel complex [GO:0001518]	GO:0001518; GO:0005261; GO:0005886; GO:0030424; GO:0030425; GO:0034703; GO:0034706; GO:0035725; GO:0055080; GO:0098908
GN007520	GN007520.1	A9JS51	27.4	292	306	311	4.14e-25	105	CMI2B_XENLA	Ciliary microtubule inner protein 2B	Xenopus laevis (African clawed frog)			axonemal microtubule [GO:0005879]	GO:0005879
GN007521	GN007521.1	P69744	28.1	638	790	723	2.28e-41	165	TRPV5_MOUSE	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3)	Mus musculus (Mouse)	calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; intracellular calcium ion homeostasis [GO:0006874]; protein homotetramerization [GO:0051289]; regulation of urine volume [GO:0035809]	calcium channel activity [GO:0005262]	apical plasma membrane [GO:0016324]; calcium channel complex [GO:0034704]; plasma membrane [GO:0005886]	GO:0005262; GO:0005886; GO:0006816; GO:0006874; GO:0016324; GO:0034704; GO:0035809; GO:0051289; GO:0055074; GO:0060402; GO:0070588; GO:0098703
GN007522	GN007522.1	Q26626	66.0	799	842	828	0.0	943	KIFA3_STRPU	Kinesin-associated protein 3 (SpKAP115)	Strongylocentrotus purpuratus (Purple sea urchin)	cilium organization [GO:0044782]; microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]	kinesin binding [GO:0019894]	axoneme [GO:0005930]; ciliary transition zone [GO:0035869]; kinesin II complex [GO:0016939]	GO:0005930; GO:0007017; GO:0007018; GO:0016939; GO:0019894; GO:0035869; GO:0044782
GN007523	GN007523.1	Q6GLB0	51.2	84	109	119	6.68e-18	75.9	PP1RB_XENTR	E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Protein phosphatase 1 regulatory subunit 11)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	defense response to Gram-positive bacterium [GO:0050830]; negative regulation of cytokine production [GO:0001818]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ubiquitin protein ligase activity [GO:0061630]	nucleus [GO:0005634]	GO:0001818; GO:0004865; GO:0005634; GO:0006511; GO:0008157; GO:0016567; GO:0050830; GO:0061630
GN007524	GN007524.1	Q9N2A3	41.0	83	265	590	2.91e-12	69.7	ACM3_GORGO	Muscarinic acetylcholine receptor M3	Gorilla gorilla gorilla (Western lowland gorilla)	adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smooth muscle contraction [GO:0045987]; saliva secretion [GO:0046541]	acetylcholine binding [GO:0042166]; G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled receptor activity [GO:0004930]; phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435]	basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0004435; GO:0004930; GO:0005789; GO:0005886; GO:0007213; GO:0016323; GO:0016907; GO:0042166; GO:0043410; GO:0045211; GO:0045987; GO:0046541; GO:0071880
GN007526	GN007526.1	Q9JI35	30.8	412	343	445	6.12e-46	165	HRH3_CAVPO	Histamine H3 receptor (H3R) (HH3R)	Cavia porcellus (Guinea pig)	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]	G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0004969; GO:0004993; GO:0005886; GO:0007187; GO:0007197; GO:0016907; GO:0030425; GO:0045202
GN007527	GN007527.1	Q9JI35	26.6	384	329	445	1.84e-39	147	HRH3_CAVPO	Histamine H3 receptor (H3R) (HH3R)	Cavia porcellus (Guinea pig)	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]	G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0004969; GO:0004993; GO:0005886; GO:0007187; GO:0007197; GO:0016907; GO:0030425; GO:0045202
GN007528	GN007528.1	Q9JI35	26.5	393	345	445	1.41e-35	137	HRH3_CAVPO	Histamine H3 receptor (H3R) (HH3R)	Cavia porcellus (Guinea pig)	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]	G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0004969; GO:0004993; GO:0005886; GO:0007187; GO:0007197; GO:0016907; GO:0030425; GO:0045202
GN007529	GN007529.1	O60879	35.5	1165	1216	1101	8.80e-161	511	DIAP2_HUMAN	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2)	Homo sapiens (Human)	actin filament polymerization [GO:0030041]; female gamete generation [GO:0007292]	actin binding [GO:0003779]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]	actin filament [GO:0005884]; cytosol [GO:0005829]; early endosome [GO:0005769]	GO:0003779; GO:0005102; GO:0005769; GO:0005829; GO:0005884; GO:0007292; GO:0030041; GO:0031267
GN007530	GN007530.1	O60879	43.5	1014	1146	1101	1.27e-234	702	DIAP2_HUMAN	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2)	Homo sapiens (Human)	actin filament polymerization [GO:0030041]; female gamete generation [GO:0007292]	actin binding [GO:0003779]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]	actin filament [GO:0005884]; cytosol [GO:0005829]; early endosome [GO:0005769]	GO:0003779; GO:0005102; GO:0005769; GO:0005829; GO:0005884; GO:0007292; GO:0030041; GO:0031267
GN007531	GN007531.1	Q5ZMS6	40.6	389	714	741	9.17e-69	243	TDRD3_CHICK	Tudor domain-containing protein 3	Gallus gallus (Chicken)	siRNA-mediated heterochromatin formation [GO:0141194]	chromatin binding [GO:0003682]; histone H3 reader activity [GO:0140006]; histone H4 reader activity [GO:0140008]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; DNA topoisomerase III-beta-TDRD3 complex [GO:0140225]; nucleus [GO:0005634]	GO:0003682; GO:0003713; GO:0003723; GO:0005634; GO:0005737; GO:0140006; GO:0140008; GO:0140225; GO:0141194
GN007532	GN007532.1	Q4L235	32.5	847	1029	1098	4.46e-111	373	ACSF4_HUMAN	Beta-alanine-activating enzyme (EC 6.2.1.-) (Acyl-CoA synthetase family member 4) (Protein NRPS998)	Homo sapiens (Human)	fatty acid metabolic process [GO:0006631]			GO:0006631
GN007533	GN007533.1	Q9UM13	58.9	185	185	185	3.35e-81	241	APC10_HUMAN	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10)	Homo sapiens (Human)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]		anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005680; GO:0005829; GO:0007346; GO:0031145; GO:0051445; GO:0070936; GO:0070979; GO:0141198
GN007534	GN007534.1	Q4QQZ4	47.5	297	299	334	2.46e-96	290	MAT2B_XENLA	Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta)	Xenopus laevis (African clawed frog)	S-adenosylmethionine biosynthetic process [GO:0006556]	enzyme regulator activity [GO:0030234]; methionine adenosyltransferase regulator activity [GO:0048270]	methionine adenosyltransferase complex [GO:0048269]	GO:0006556; GO:0030234; GO:0048269; GO:0048270
GN007535	GN007535.1	Q8K0U4	31.7	379	343	675	1.12e-44	165	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007536	GN007536.1	O43301	31.5	485	442	675	5.00e-62	216	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN007537	GN007537.1	O43301	32.1	635	580	675	8.14e-100	320	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN007538	GN007538.1	Q8K0U4	31.6	450	409	675	3.86e-62	215	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007539	GN007539.1	Q96MM6	42.7	89	104	686	1.61e-11	62.4	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN007543	GN007543.1	O02373	63.3	196	204	476	5.53e-81	251	UGDH_DROME	UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (Protein sugarless) (Protein suppenkasper)	Drosophila melanogaster (Fruit fly)	chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; epithelial cell migration, open tracheal system [GO:0007427]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; mesoderm migration involved in gastrulation [GO:0007509]; segment polarity determination [GO:0007367]; UDP-glucuronate biosynthetic process [GO:0006065]	NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003979; GO:0005634; GO:0005737; GO:0005829; GO:0006024; GO:0006065; GO:0007367; GO:0007427; GO:0007509; GO:0008543; GO:0015012; GO:0050650; GO:0051287
GN007544	GN007544.1	P55906	40.0	145	212	683	6.36e-19	87.8	BGH3_BOVIN	Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (MP70) (MP78)	Bos taurus (Bovine)	extracellular matrix organization [GO:0030198]; homophilic cell-cell adhesion [GO:0007156]	cell adhesion molecule binding [GO:0050839]	cell periphery [GO:0071944]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0007156; GO:0030198; GO:0031012; GO:0050839; GO:0071944
GN007545	GN007545.1	P55906	26.8	276	307	683	2.94e-14	76.6	BGH3_BOVIN	Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (MP70) (MP78)	Bos taurus (Bovine)	extracellular matrix organization [GO:0030198]; homophilic cell-cell adhesion [GO:0007156]	cell adhesion molecule binding [GO:0050839]	cell periphery [GO:0071944]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0007156; GO:0030198; GO:0031012; GO:0050839; GO:0071944
GN007547	GN007547.1	Q5G267	52.9	104	392	875	3.04e-27	117	NETR_MACMU	Neurotrypsin (EC 3.4.21.-) (Serine protease 12)	Macaca mulatta (Rhesus macaque)	exocytosis [GO:0006887]; zymogen activation [GO:0031638]	serine-type endopeptidase activity [GO:0004252]	axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; terminal bouton [GO:0043195]	GO:0004252; GO:0005886; GO:0006887; GO:0030424; GO:0030425; GO:0031638; GO:0043083; GO:0043195; GO:0098978
GN007548	GN007548.1	Q8K0U4	33.7	567	594	675	5.79e-96	310	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007550	GN007550.1	A0A1S4F2V5	60.3	237	264	339	2.13e-104	309	CATL_AEDAE	Cathepsin L-like peptidase (AaCatL) (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain]	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	proteolysis [GO:0006508]	cysteine-type endopeptidase activity [GO:0004197]		GO:0004197; GO:0006508
GN007551	GN007551.1	A0A1S4F2V5	59.6	156	156	339	1.64e-65	206	CATL_AEDAE	Cathepsin L-like peptidase (AaCatL) (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain]	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	proteolysis [GO:0006508]	cysteine-type endopeptidase activity [GO:0004197]		GO:0004197; GO:0006508
GN007554	GN007554.1	Q6NRD3	35.1	900	768	826	3.84e-119	381	SH3R1_XENLA	E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (xPOSH) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1)	Xenopus laevis (African clawed frog)	negative regulation of apoptotic process [GO:0043066]; neuron migration [GO:0001764]; positive regulation of JNK cascade [GO:0046330]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autoubiquitination [GO:0051865]; regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043370]; regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000564]	MAP kinase scaffold activity [GO:0005078]; ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]	GO:0001764; GO:0005078; GO:0005794; GO:0005829; GO:0030027; GO:0032436; GO:0043066; GO:0043370; GO:0046330; GO:0048471; GO:0051865; GO:0061630; GO:2000564
GN007555	GN007555.1	B0V207	35.6	944	949	1124	6.86e-114	379	FHI1B_DANRE	FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein homolog) (FHIP)	Danio rerio (Zebrafish) (Brachydanio rerio)	early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein localization to perinuclear region of cytoplasm [GO:1905719]		FHF complex [GO:0070695]	GO:0007032; GO:0007040; GO:0008333; GO:0045022; GO:0070695; GO:1905719
GN007556	GN007556.1	Q921G7	73.2	585	613	616	0.0	925	ETFD_MOUSE	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase)	Mus musculus (Mouse)	electron transport chain [GO:0022900]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; response to oxidative stress [GO:0006979]	4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; electron-transferring-flavoprotein dehydrogenase activity [GO:0004174]; iron-sulfur cluster binding [GO:0051536]; oxidoreductase activity [GO:0016491]; quinone binding [GO:0048038]; ubiquinone binding [GO:0048039]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial electron transfer flavoprotein complex [GO:0017133]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0004174; GO:0005654; GO:0005739; GO:0005743; GO:0005829; GO:0006979; GO:0009055; GO:0016020; GO:0016491; GO:0017133; GO:0022900; GO:0031966; GO:0033539; GO:0048038; GO:0048039; GO:0051536; GO:0051539
GN007557	GN007557.1	Q99J23	33.4	365	638	532	2.92e-56	202	GHDC_MOUSE	GH3 domain-containing protein	Mus musculus (Mouse)			endoplasmic reticulum [GO:0005783]; nuclear envelope [GO:0005635]	GO:0005635; GO:0005783
GN007558	GN007558.1	Q9WV82	25.9	432	668	838	4.89e-28	124	TLR4_CRIGR	Toll-like receptor 4 (CD antigen CD284)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	cellular response to amyloid-beta [GO:1904646]; cellular response to mechanical stimulus [GO:0071260]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to type II interferon [GO:0071346]; defense response to Gram-negative bacterium [GO:0050829]; detection of lipopolysaccharide [GO:0032497]; intestinal epithelial structure maintenance [GO:0060729]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-23 production [GO:0032707]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type II interferon production [GO:0032689]; phagocytosis [GO:0006909]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cellular response to macrophage colony-stimulating factor stimulus [GO:1903974]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage activation [GO:0043032]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of platelet activation [GO:0010572]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; toll-like receptor 4 signaling pathway [GO:0034142]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; wound healing involved in inflammatory response [GO:0002246]	identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide immune receptor activity [GO:0001875]; protein heterodimerization activity [GO:0046982]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]	early endosome [GO:0005769]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; lipopolysaccharide receptor complex [GO:0046696]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GO:0001530; GO:0001726; GO:0001875; GO:0001891; GO:0002246; GO:0002755; GO:0004888; GO:0005102; GO:0005769; GO:0005886; GO:0006909; GO:0009897; GO:0010008; GO:0010572; GO:0032497; GO:0032689; GO:0032700; GO:0032707; GO:0032715; GO:0032720; GO:0032727; GO:0032728; GO:0032729; GO:0032731; GO:0032733; GO:0032735; GO:0032755; GO:0032757; GO:0032760; GO:0034142; GO:0035666; GO:0036120; GO:0042116; GO:0042802; GO:0043032; GO:0043123; GO:0045944; GO:0046696; GO:0046982; GO:0048471; GO:0050729; GO:0050829; GO:0060729; GO:0070373; GO:0071260; GO:0071346; GO:0120163; GO:0140052; GO:1900017; GO:1900227; GO:1903428; GO:1903974; GO:1904466; GO:1904646; GO:2000343; GO:2001238
GN007559	GN007559.1	A8WHP3	43.1	425	444	657	2.26e-121	370	SC5A9_DANRE	Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9)	Danio rerio (Zebrafish) (Brachydanio rerio)		carbohydrate:monoatomic cation symporter activity [GO:0005402]; hexose transmembrane transporter activity [GO:0015149]; solute:sodium symporter activity [GO:0015370]; transmembrane transporter activity [GO:0022857]	plasma membrane [GO:0005886]	GO:0005402; GO:0005886; GO:0015149; GO:0015370; GO:0022857
GN007563	GN007563.1	Q9BY43	46.6	223	227	222	1.07e-40	141	CHM4A_HUMAN	Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1)	Homo sapiens (Human)	autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; late endosome to lysosome transport [GO:1902774]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; membrane invagination [GO:0010324]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; multivesicular body-lysosome fusion [GO:0061763]; nervous system process [GO:0050877]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; plasma membrane tubulation [GO:0097320]; post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein polymerization [GO:0051258]; regulation of mitotic spindle assembly [GO:1901673]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; vesicle budding from membrane [GO:0006900]; vesicle fusion with vacuole [GO:0051469]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	amphisome membrane [GO:1904930]; autophagosome membrane [GO:0000421]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lysosomal membrane [GO:0005765]; membrane coat [GO:0030117]; midbody [GO:0030496]; multivesicular body membrane [GO:0032585]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000421; GO:0000776; GO:0000815; GO:0001778; GO:0005634; GO:0005635; GO:0005643; GO:0005737; GO:0005765; GO:0005828; GO:0005829; GO:0005886; GO:0006620; GO:0006900; GO:0006914; GO:0006997; GO:0007080; GO:0009898; GO:0010324; GO:0016236; GO:0030117; GO:0030496; GO:0031468; GO:0032511; GO:0032585; GO:0036258; GO:0039702; GO:0042802; GO:0042803; GO:0043162; GO:0046761; GO:0050877; GO:0051117; GO:0051258; GO:0051469; GO:0061763; GO:0061952; GO:0071985; GO:0090148; GO:0097320; GO:0097352; GO:1901673; GO:1902774; GO:1904930
GN007565	GN007565.1	Q96JA3	37.2	401	383	519	1.13e-70	233	PKHA8_HUMAN	Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) (Phosphatidylinositol-four-phosphate adapter protein 2) (FAPP-2) (Phosphoinositol 4-phosphate adapter protein 2) (hFAPP2) (Serologically defined breast cancer antigen NY-BR-86)	Homo sapiens (Human)	ER to Golgi ceramide transport [GO:0035621]; globoside biosynthetic process [GO:0001576]; glycolipid transport [GO:0046836]; intermembrane lipid transfer [GO:0120009]; lipid transport [GO:0006869]; phosphatidylinositol biosynthetic process [GO:0006661]	ceramide 1-phosphate binding [GO:1902387]; ceramide binding [GO:0097001]; cerebroside transfer activity [GO:0140340]; glycolipid binding [GO:0051861]; glycolipid transfer activity [GO:0017089]; glycosphingolipid binding [GO:0043208]; molecular carrier activity [GO:0140104]; phosphatidylinositol-4-phosphate binding [GO:0070273]; small GTPase binding [GO:0031267]	cis-Golgi network membrane [GO:0033106]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0001576; GO:0005654; GO:0005802; GO:0005829; GO:0006661; GO:0006869; GO:0017089; GO:0031267; GO:0033106; GO:0035621; GO:0043208; GO:0046836; GO:0051861; GO:0070273; GO:0097001; GO:0120009; GO:0140104; GO:0140340; GO:1902387
GN007567	GN007567.1	R9UTQ8	34.1	179	288	268	4.76e-21	93.2	PROHY_STRGD	L-proline trans-4-hydroxylase (P4H) (EC 1.14.11.57)	Streptomyces griseoviridis	antibiotic metabolic process [GO:0016999]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506]		GO:0005506; GO:0016706; GO:0016999
GN007571	GN007571.1	F1Q8J0	40.4	443	421	505	1.38e-64	218	RNPC3_DANRE	RNA-binding region-containing protein 3 (RNA-binding protein 40)	Danio rerio (Zebrafish) (Brachydanio rerio)	digestive tract development [GO:0048565]; liver development [GO:0001889]; mRNA splicing, via spliceosome [GO:0000398]; pancreas development [GO:0031016]	RNA binding [GO:0003723]	U12-type spliceosomal complex [GO:0005689]	GO:0000398; GO:0001889; GO:0003723; GO:0005689; GO:0031016; GO:0048565
GN007572	GN007572.1	P30260	53.9	740	708	824	1.70e-92	308	CDC27_HUMAN	Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)	Homo sapiens (Human)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of meiotic cell cycle [GO:0051445]; regulation of mitotic cell cycle [GO:0007346]	enzyme-substrate adaptor activity [GO:0140767]; protein phosphatase binding [GO:0019903]	anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0005634; GO:0005654; GO:0005680; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0007091; GO:0007346; GO:0016567; GO:0019903; GO:0031145; GO:0051301; GO:0051445; GO:0070936; GO:0070979; GO:0072686; GO:0140767; GO:0141198
GN007573	GN007573.1	A8WHP3	52.3	608	605	657	2.21e-216	620	SC5A9_DANRE	Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9)	Danio rerio (Zebrafish) (Brachydanio rerio)		carbohydrate:monoatomic cation symporter activity [GO:0005402]; hexose transmembrane transporter activity [GO:0015149]; solute:sodium symporter activity [GO:0015370]; transmembrane transporter activity [GO:0022857]	plasma membrane [GO:0005886]	GO:0005402; GO:0005886; GO:0015149; GO:0015370; GO:0022857
GN007579	GN007579.1	Q6KAU4	32.2	270	301	317	5.62e-30	118	MB12B_MOUSE	Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B)	Mus musculus (Mouse)	regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; viral budding [GO:0046755]; virus maturation [GO:0019075]	lipid binding [GO:0008289]	cytosol [GO:0005829]; early endosome [GO:0005769]; ESCRT I complex [GO:0000813]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GO:0000813; GO:0005634; GO:0005769; GO:0005770; GO:0005829; GO:0005886; GO:0008289; GO:0019075; GO:0031902; GO:0031982; GO:0042058; GO:0046755
GN007580	GN007580.1	Q9WVR6	54.2	480	498	533	2.48e-174	504	LAT2_RAT	Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (Solute carrier family 7 member 8)	Rattus norvegicus (Rat)	amino acid import across plasma membrane [GO:0089718]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; glycine transport [GO:0015816]; L-alanine import across plasma membrane [GO:1904273]; L-amino acid transport [GO:0015807]; L-leucine import across plasma membrane [GO:1903801]; L-leucine transport [GO:0015820]; neutral amino acid transport [GO:0015804]; proline transmembrane transport [GO:0035524]; thyroid hormone transport [GO:0070327]; tryptophan transport [GO:0015827]; valine transport [GO:0015829]	amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-amino acid transmembrane transporter activity [GO:0015179]; L-leucine transmembrane transporter activity [GO:0015190]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; peptide antigen binding [GO:0042605]; protein heterodimerization activity [GO:0046982]; thyroid hormone transmembrane transporter activity [GO:0015349]; toxin transmembrane transporter activity [GO:0019534]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]	GO:0003333; GO:0005886; GO:0006865; GO:0009925; GO:0015171; GO:0015175; GO:0015179; GO:0015180; GO:0015187; GO:0015190; GO:0015297; GO:0015349; GO:0015804; GO:0015807; GO:0015816; GO:0015820; GO:0015827; GO:0015829; GO:0016323; GO:0016324; GO:0019534; GO:0022857; GO:0031528; GO:0035524; GO:0042605; GO:0046982; GO:0070327; GO:0089718; GO:1902495; GO:1903801; GO:1904273
GN007582	GN007582.1	Q8N2E2	25.3	297	330	1590	2.07e-23	104	VWDE_HUMAN	von Willebrand factor D and EGF domain-containing protein	Homo sapiens (Human)		signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]	GO:0005102; GO:0005576; GO:0009986
GN007584	GN007584.1	Q8N2E2	25.6	1139	1016	1590	1.06e-89	318	VWDE_HUMAN	von Willebrand factor D and EGF domain-containing protein	Homo sapiens (Human)		signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]	GO:0005102; GO:0005576; GO:0009986
GN007585	GN007585.1	Q9UL19	37.4	91	138	164	2.36e-14	68.9	PLAT4_HUMAN	Phospholipase A and acyltransferase 4 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 4) (HRSL4) (RAR-responsive protein TIG3) (Retinoic acid receptor responder protein 3) (Retinoid-inducible gene 1 protein) (Tazarotene-induced gene 3 protein)	Homo sapiens (Human)	N-acylphosphatidylethanolamine metabolic process [GO:0070292]; negative regulation of cell population proliferation [GO:0008285]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phospholipid metabolic process [GO:0006644]	A2-type glycerophospholipase activity [GO:0004623]; acyltransferase activity [GO:0016746]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; glycerophospholipid phospholipase A1 activity [GO:0008970]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	GO:0004623; GO:0005737; GO:0005829; GO:0006644; GO:0008285; GO:0008970; GO:0016020; GO:0016746; GO:0016747; GO:0036152; GO:0070292
GN007587	GN007587.1	P53816	30.2	159	178	162	1.33e-18	81.3	PLAT3_HUMAN	Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) (H-REV107) (HREV107-1) (HRAS-like suppressor 1) (HRAS-like suppressor 3) (HRSL3) (HREV107-3) (Renal carcinoma antigen NY-REN-65)	Homo sapiens (Human)	ether lipid metabolic process [GO:0046485]; lens fiber cell differentiation [GO:0070306]; lipid catabolic process [GO:0016042]; membrane disassembly [GO:0030397]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; organelle disassembly [GO:1903008]; peroxisome organization [GO:0007031]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phospholipid biosynthetic process [GO:0008654]; phospholipid metabolic process [GO:0006644]; regulation of adipose tissue development [GO:1904177]; triglyceride metabolic process [GO:0006641]	A2-type glycerophospholipase activity [GO:0004623]; acyltransferase activity [GO:0016746]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; glycerophospholipid phospholipase A1 activity [GO:0008970]; lipid binding [GO:0008289]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]	GO:0004623; GO:0005635; GO:0005737; GO:0005739; GO:0005764; GO:0005765; GO:0005777; GO:0005778; GO:0005783; GO:0005789; GO:0005829; GO:0005886; GO:0006641; GO:0006644; GO:0007031; GO:0008289; GO:0008654; GO:0008970; GO:0016042; GO:0016746; GO:0016747; GO:0030397; GO:0031966; GO:0036152; GO:0046485; GO:0048471; GO:0070292; GO:0070306; GO:1903008; GO:1904177
GN007589	GN007589.1	Q5R611	34.3	166	172	162	7.68e-23	92.0	PLAT3_PONAB	Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A2) (H-rev 107 protein homolog) (HRAS-like suppressor 3) (HRSL3)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	ether lipid metabolic process [GO:0046485]; lens fiber cell differentiation [GO:0070306]; lipid catabolic process [GO:0016042]; membrane disassembly [GO:0030397]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; organelle disassembly [GO:1903008]; peroxisome organization [GO:0007031]; phospholipid metabolic process [GO:0006644]; regulation of adipose tissue development [GO:1904177]; triglyceride metabolic process [GO:0006641]	A2-type glycerophospholipase activity [GO:0004623]; acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; glycerophospholipase activity [GO:0004620]; glycerophospholipid phospholipase A1 activity [GO:0008970]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]	GO:0004620; GO:0004623; GO:0005635; GO:0005737; GO:0005739; GO:0005764; GO:0005765; GO:0005777; GO:0005778; GO:0005783; GO:0005789; GO:0005829; GO:0005886; GO:0006641; GO:0006644; GO:0007031; GO:0008970; GO:0016042; GO:0016747; GO:0030397; GO:0031966; GO:0046485; GO:0048471; GO:0070292; GO:0070306; GO:1903008; GO:1904177
GN007591	GN007591.1	Q8NBX0	36.6	112	256	429	5.80e-16	80.1	SCPDL_HUMAN	Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-)	Homo sapiens (Human)	glycolipid biosynthetic process [GO:0009247]		extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]	GO:0005576; GO:0005634; GO:0005739; GO:0005811; GO:0009247; GO:0016020; GO:0030496; GO:0031093
GN007593	GN007593.1	Q8MRC9	33.5	269	313	650	3.26e-42	157	GALT9_DROME	Putative polypeptide N-acetylgalactosaminyltransferase 9 (pp-GaNTase 9) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 9) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9)	Drosophila melanogaster (Fruit fly)	protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via N-acetyl-galactosamine [GO:0016266]	polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0004653; GO:0005794; GO:0006493; GO:0016020; GO:0016266; GO:0031985
GN007596	GN007596.1	Q2T9X7	79.9	154	234	207	2.81e-88	262	UB2E3_BOVIN	Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (Ubiquitin carrier protein E3) (Ubiquitin-protein ligase E3)	Bos taurus (Bovine)	protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]	ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004842; GO:0005634; GO:0005737; GO:0061631; GO:0070534; GO:0070936; GO:0070979
GN007600	GN007600.1	Q3MI00	56.1	66	573	340	3.07e-13	74.7	DNJB1_BOVIN	DnaJ homolog subfamily B member 1	Bos taurus (Bovine)	cellular response to heat [GO:0034605]; negative regulation of inclusion body assembly [GO:0090084]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein folding [GO:1903334]; protein folding [GO:0006457]	ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; Hsp70 protein binding [GO:0030544]; protein folding chaperone [GO:0044183]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0000122; GO:0001671; GO:0003714; GO:0005654; GO:0005730; GO:0005829; GO:0006457; GO:0030544; GO:0034605; GO:0044183; GO:0051117; GO:0090084; GO:0140416; GO:1903334
GN007601	GN007601.1	P08953	27.8	374	605	1097	2.13e-26	118	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN007602	GN007602.1	Q9V477	36.3	179	651	1346	2.51e-26	119	TOLL8_DROME	Toll-like receptor Tollo (Toll-like receptor 8)	Drosophila melanogaster (Fruit fly)	axis elongation [GO:0003401]; convergent extension [GO:0060026]; peripheral nervous system neuron development [GO:0048935]; regulation of glycoprotein biosynthetic process [GO:0010559]; signal transduction [GO:0007165]	receptor ligand activity [GO:0048018]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0003401; GO:0005886; GO:0007165; GO:0010559; GO:0016324; GO:0048018; GO:0048935; GO:0060026
GN007606	GN007606.1	Q9Y2C9	29.7	246	686	796	2.91e-23	108	TLR6_HUMAN	Toll-like receptor 6 (CD antigen CD286)	Homo sapiens (Human)	activation of NF-kappaB-inducing kinase activity [GO:0007250]; antibacterial innate immune response [GO:0140367]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide metabolic process [GO:0046209]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macrophage activation [GO:0043032]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	amyloid-beta binding [GO:0001540]; diacyl lipopeptide binding [GO:0042498]; identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	GO:0001540; GO:0001774; GO:0002224; GO:0002755; GO:0004888; GO:0005102; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0007165; GO:0007250; GO:0010628; GO:0030670; GO:0031663; GO:0032717; GO:0032720; GO:0032731; GO:0032755; GO:0034136; GO:0035355; GO:0035663; GO:0035666; GO:0038023; GO:0038124; GO:0042496; GO:0042498; GO:0042742; GO:0042802; GO:0043032; GO:0043123; GO:0043235; GO:0043507; GO:0045087; GO:0045121; GO:0045429; GO:0046209; GO:0046982; GO:0050729; GO:0071723; GO:0071726; GO:0140052; GO:0140367; GO:1900017; GO:1900227; GO:1903428; GO:1904646; GO:2001238
GN007609	GN007609.1	Q4V863	54.9	730	723	748	1.14e-262	746	EZH2B_XENLA	Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (Enhancer of zeste homolog 2-B)	Xenopus laevis (African clawed frog)	heterochromatin formation [GO:0031507]; negative regulation of gene expression, epigenetic [GO:0045814]	chromatin binding [GO:0003682]; histone H3K27 trimethyltransferase activity [GO:0140951]; promoter-specific chromatin binding [GO:1990841]	ESC/E(Z) complex [GO:0035098]; nucleus [GO:0005634]	GO:0003682; GO:0005634; GO:0031507; GO:0035098; GO:0045814; GO:0140951; GO:1990841
GN007611	GN007611.1	Q7ZU45	46.6	496	893	486	1.11e-131	406	ODAD4_DANRE	Outer dynein arm-docking complex subunit 4 (Tetratricopeptide repeat protein 25) (TPR repeat protein 25)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; cilium movement [GO:0003341]; determination of heart left/right asymmetry [GO:0061371]; otolith morphogenesis [GO:0032474]; outer dynein arm assembly [GO:0036158]		axoneme [GO:0005930]; cytoplasm [GO:0005737]	GO:0003341; GO:0005737; GO:0005930; GO:0032474; GO:0036158; GO:0060271; GO:0061371
GN007612	GN007612.1	P13674	27.0	326	338	534	6.33e-20	94.0	P4HA1_HUMAN	Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)	Homo sapiens (Human)	collagen fibril organization [GO:0030199]	identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 4-dioxygenase activity [GO:0004656]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; membrane [GO:0016020]; procollagen-proline 4-dioxygenase complex [GO:0016222]	GO:0004656; GO:0005506; GO:0005783; GO:0005788; GO:0016020; GO:0016222; GO:0030199; GO:0031418; GO:0042802
GN007614	GN007614.1	Q91145	32.3	186	334	929	4.22e-17	85.9	COCA1_NOTVI	Collagen alpha-1(XII) chain	Notophthalmus viridescens (Eastern newt) (Triturus viridescens)	cell-matrix adhesion [GO:0007160]; cell-substrate junction assembly [GO:0007044]; heart development [GO:0007507]; nervous system development [GO:0007399]	extracellular matrix structural constituent [GO:0005201]; integrin binding [GO:0005178]; proteoglycan binding [GO:0043394]		GO:0005178; GO:0005201; GO:0007044; GO:0007160; GO:0007399; GO:0007507; GO:0043394
GN007615	GN007615.1	O14513	41.4	295	1946	1909	1.99e-33	145	NCKP5_HUMAN	Nck-associated protein 5 (NAP-5) (Peripheral clock protein)	Homo sapiens (Human)	microtubule bundle formation [GO:0001578]; microtubule depolymerization [GO:0007019]		microtubule plus-end [GO:0035371]	GO:0001578; GO:0007019; GO:0035371
GN007616	GN007616.1	Q9TZH6	75.6	90	102	142	6.61e-43	139	PHS_CAEEL	Putative pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Pterin carbinolamine dehydratase) (PCD)	Caenorhabditis elegans	tetrahydrobiopterin biosynthetic process [GO:0006729]	4-alpha-hydroxytetrahydrobiopterin dehydratase activity [GO:0008124]		GO:0006729; GO:0008124
GN007617	GN007617.1	G5EBQ8	37.5	1013	1506	1668	1.26e-180	587	CHS2_CAEEL	Chitin synthase chs-2 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase chs-2)	Caenorhabditis elegans	chitin biosynthetic process [GO:0006031]; positive regulation of nematode larval development [GO:0061063]	chitin synthase activity [GO:0004100]	plasma membrane [GO:0005886]	GO:0004100; GO:0005886; GO:0006031; GO:0061063
GN007619	GN007619.1	G5EBQ8	32.8	1347	1537	1668	9.06e-180	585	CHS2_CAEEL	Chitin synthase chs-2 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase chs-2)	Caenorhabditis elegans	chitin biosynthetic process [GO:0006031]; positive regulation of nematode larval development [GO:0061063]	chitin synthase activity [GO:0004100]	plasma membrane [GO:0005886]	GO:0004100; GO:0005886; GO:0006031; GO:0061063
GN007623	GN007623.1	Q0VAA2	31.1	148	774	488	5.00e-13	75.9	LR74A_HUMAN	Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74)	Homo sapiens (Human)				
GN007625	GN007625.1	O95831	48.5	478	546	613	1.23e-151	451	AIFM1_HUMAN	Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8)	Homo sapiens (Human)	apoptotic process [GO:0006915]; cellular response to aldosterone [GO:1904045]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to nitric oxide [GO:0071732]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mitochondrial respiratory chain complex assembly [GO:0033108]; neuron differentiation [GO:0030182]; positive regulation of apoptotic process [GO:0043065]; positive regulation of necroptotic process [GO:0060545]; positive regulation of neuron apoptotic process [GO:0043525]; protein import into mitochondrial intermembrane space [GO:0045041]; protein import into the intermembrane space via the disulfide relay system [GO:0160203]; response to ischemia [GO:0002931]; response to L-glutamate [GO:1902065]; response to toxic substance [GO:0009636]	DNA binding [GO:0003677]; FAD binding [GO:0071949]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADH binding [GO:0070404]; NADH dehydrogenase activity [GO:0003954]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]; poly-ADP-D-ribose binding [GO:0072572]; protein dimerization activity [GO:0046983]; protein-membrane adaptor activity [GO:0043495]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0002931; GO:0003677; GO:0003954; GO:0005634; GO:0005737; GO:0005739; GO:0005743; GO:0005758; GO:0005829; GO:0006915; GO:0009636; GO:0016174; GO:0016651; GO:0030182; GO:0033108; GO:0043065; GO:0043495; GO:0043525; GO:0045041; GO:0046983; GO:0048471; GO:0060545; GO:0070059; GO:0070301; GO:0070404; GO:0071392; GO:0071456; GO:0071732; GO:0071949; GO:0072572; GO:0160203; GO:1902065; GO:1904045
GN007627	GN007627.1	A5PK00	56.9	385	382	386	1.54e-151	436	VPS36_BOVIN	Vacuolar protein-sorting-associated protein 36 (ESCRT-II complex subunit VPS36)	Bos taurus (Bovine)	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]	phosphatidylinositol-3-phosphate binding [GO:0032266]; ubiquitin binding [GO:0043130]	endosome [GO:0005768]; ESCRT II complex [GO:0000814]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; nucleus [GO:0005634]	GO:0000814; GO:0005634; GO:0005768; GO:0005770; GO:0031902; GO:0032266; GO:0043130; GO:0043328
GN007628	GN007628.1	A5PKL6	32.1	720	717	631	1.34e-100	325	GSTCD_BOVIN	Glutathione S-transferase C-terminal domain-containing protein	Bos taurus (Bovine)			cytoplasm [GO:0005737]	GO:0005737
GN007629	GN007629.1	Q9R1V3	75.9	481	453	465	1.87e-256	707	SMAD5_RAT	SMAD family member 5 (SMAD 5) (Mothers against decapentaplegic homolog 5) (MAD homolog 5) (Mothers against DPP homolog 5)	Rattus norvegicus (Rat)	anatomical structure morphogenesis [GO:0009653]; anti-Mullerian hormone receptor signaling pathway [GO:1990262]; BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cardiac muscle contraction [GO:0060048]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; embryonic pattern specification [GO:0009880]; erythrocyte differentiation [GO:0030218]; germ cell development [GO:0007281]; intracellular iron ion homeostasis [GO:0006879]; Mullerian duct regression [GO:0001880]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Fas signaling pathway [GO:1902045]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; osteoblast fate commitment [GO:0002051]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of ossification [GO:0030278]; regulation of transcription by RNA polymerase II [GO:0006357]; SMAD protein signal transduction [GO:0060395]; stem cell differentiation [GO:0048863]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]	DEAD/H-box RNA helicase binding [GO:0017151]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; I-SMAD binding [GO:0070411]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; heteromeric SMAD protein complex [GO:0071144]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000122; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0001503; GO:0001649; GO:0001657; GO:0001880; GO:0002051; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0006357; GO:0006468; GO:0006879; GO:0007179; GO:0007281; GO:0009653; GO:0009880; GO:0010629; GO:0017151; GO:0030154; GO:0030218; GO:0030278; GO:0030509; GO:0031625; GO:0032991; GO:0043066; GO:0045669; GO:0045944; GO:0048863; GO:0051216; GO:0060048; GO:0060348; GO:0060395; GO:0070411; GO:0071144; GO:1902045; GO:1990262; GO:1990837
GN007630	GN007630.1	Q8R179	25.8	159	187	534	1.18e-15	77.4	KBTB4_MOUSE	Kelch repeat and BTB domain-containing protein 4 (BTB and kelch domain-containing protein 4)	Mus musculus (Mouse)				
GN007631	GN007631.1	Q922Q6	38.0	192	271	247	1.03e-40	144	ABHEA_MOUSE	Protein ABHD14A (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 14A) (Abhydrolase domain-containing protein 14A) (Down-regulated in Zic-1-mutant protein)	Mus musculus (Mouse)			cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0005737; GO:0016020
GN007632	GN007632.1	P58389	60.0	275	356	323	7.93e-120	352	PTPA_MOUSE	Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')	Mus musculus (Mouse)	mitotic spindle organization [GO:0007052]; positive regulation of apoptotic process [GO:0043065]	ATP binding [GO:0005524]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphatase binding [GO:0019902]; phosphoprotein phosphatase activity [GO:0004721]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888]; protein tyrosine phosphatase activator activity [GO:0008160]; signaling receptor binding [GO:0005102]	ATPase complex [GO:1904949]; calcium channel complex [GO:0034704]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	GO:0000159; GO:0003755; GO:0004721; GO:0005102; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007052; GO:0008160; GO:0019888; GO:0019902; GO:0034704; GO:0042803; GO:0043065; GO:0051721; GO:1904949
GN007633	GN007633.1	P82147	39.1	92	223	187	1.49e-12	67.0	L2EFL_DROME	Protein lethal(2)essential for life (Protein Efl21)	Drosophila melanogaster (Fruit fly)	negative regulation of translational initiation [GO:0045947]; protein refolding [GO:0042026]; response to heat [GO:0009408]; sarcomere organization [GO:0045214]	unfolded protein holdase activity [GO:0140309]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018]	GO:0005634; GO:0005737; GO:0009408; GO:0030018; GO:0042026; GO:0045214; GO:0045947; GO:0048471; GO:0140309
GN007635	GN007635.1	Q24151	24.4	475	1120	761	2.29e-19	97.8	STAT_DROME	Signal transducer and transcription activator (d-STAT) (Protein marelle)	Drosophila melanogaster (Fruit fly)	antiviral innate immune response [GO:0140374]; blastoderm segmentation [GO:0007350]; border follicle cell migration [GO:0007298]; cell dedifferentiation [GO:0043697]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cell surface receptor signaling pathway via STAT [GO:0097696]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to X-ray [GO:0071481]; defense response [GO:0006952]; determination of digestive tract left/right asymmetry [GO:0071907]; eye-antennal disc morphogenesis [GO:0007455]; follicle cell of egg chamber stalk formation [GO:0030713]; germ-line stem cell population maintenance [GO:0030718]; hindgut morphogenesis [GO:0007442]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; larval somatic muscle development [GO:0007526]; long-term memory [GO:0007616]; lymph gland development [GO:0048542]; male germ-line sex determination [GO:0019100]; negative regulation of antimicrobial humoral response [GO:0008348]; negative regulation of stem cell differentiation [GO:2000737]; nervous system development [GO:0007399]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of heterochromatin formation [GO:0031453]; primary sex determination [GO:0007538]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; segment specification [GO:0007379]; stem cell division [GO:0017145]; stem cell population maintenance [GO:0019827]; tissue regeneration [GO:0042246]; wing disc morphogenesis [GO:0007472]; wound healing [GO:0042060]	cytokine receptor binding [GO:0005126]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone binding [GO:0042393]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; cytoplasmic side of apical plasma membrane [GO:0098592]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0002230; GO:0003677; GO:0005126; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006357; GO:0006952; GO:0007259; GO:0007298; GO:0007350; GO:0007379; GO:0007399; GO:0007424; GO:0007442; GO:0007455; GO:0007472; GO:0007526; GO:0007538; GO:0007616; GO:0008284; GO:0008348; GO:0017145; GO:0019100; GO:0019827; GO:0030713; GO:0030718; GO:0030720; GO:0031453; GO:0035167; GO:0035171; GO:0036335; GO:0042060; GO:0042127; GO:0042246; GO:0042393; GO:0043697; GO:0048477; GO:0048542; GO:0071222; GO:0071481; GO:0071907; GO:0097696; GO:0098592; GO:0140374; GO:2000737
GN007639	GN007639.1	Q8N695	39.4	568	652	610	2.00e-124	384	SC5A8_HUMAN	Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8)	Homo sapiens (Human)	acetate transport [GO:0006846]; chloride transport [GO:0006821]; iodide transport [GO:0015705]; lactate transport [GO:0015727]; nicotinate metabolic process [GO:1901847]; nicotinate transport [GO:2001142]; nitrate transmembrane transport [GO:0015706]; propanoate transmembrane transport [GO:0015730]; pyruvate transport [GO:0006848]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085]	iodide channel activity [GO:0160081]; lactate transmembrane transporter activity [GO:0015129]; monocarboxylate:sodium symporter activity [GO:0140161]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; nicotinate transmembrane transporter activity [GO:0090416]; organic acid:sodium symporter activity [GO:0005343]; propionate transmembrane transporter activity [GO:0015552]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; GINS complex [GO:0000811]; plasma membrane [GO:0005886]	GO:0000811; GO:0005343; GO:0005886; GO:0006814; GO:0006821; GO:0006846; GO:0006848; GO:0008028; GO:0015129; GO:0015552; GO:0015705; GO:0015706; GO:0015727; GO:0015730; GO:0016324; GO:0055085; GO:0070062; GO:0090416; GO:0140161; GO:0160081; GO:1901847; GO:2001142
GN007640	GN007640.1	Q8N695	41.7	575	607	610	1.71e-132	404	SC5A8_HUMAN	Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8)	Homo sapiens (Human)	acetate transport [GO:0006846]; chloride transport [GO:0006821]; iodide transport [GO:0015705]; lactate transport [GO:0015727]; nicotinate metabolic process [GO:1901847]; nicotinate transport [GO:2001142]; nitrate transmembrane transport [GO:0015706]; propanoate transmembrane transport [GO:0015730]; pyruvate transport [GO:0006848]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085]	iodide channel activity [GO:0160081]; lactate transmembrane transporter activity [GO:0015129]; monocarboxylate:sodium symporter activity [GO:0140161]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; nicotinate transmembrane transporter activity [GO:0090416]; organic acid:sodium symporter activity [GO:0005343]; propionate transmembrane transporter activity [GO:0015552]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; GINS complex [GO:0000811]; plasma membrane [GO:0005886]	GO:0000811; GO:0005343; GO:0005886; GO:0006814; GO:0006821; GO:0006846; GO:0006848; GO:0008028; GO:0015129; GO:0015552; GO:0015705; GO:0015706; GO:0015727; GO:0015730; GO:0016324; GO:0055085; GO:0070062; GO:0090416; GO:0140161; GO:0160081; GO:1901847; GO:2001142
GN007641	GN007641.1	G5EFC3	25.3	505	502	558	8.43e-40	154	KCNAG_CAEEL	Potassium voltage-gated channel protein egl-36 (Egg-laying defective protein 36)	Caenorhabditis elegans	action potential [GO:0001508]; monoatomic ion transmembrane transport [GO:0034220]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic ion channel activity [GO:0005244]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005244; GO:0005251; GO:0008076; GO:0016020; GO:0032590; GO:0032809; GO:0034220; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN007642	GN007642.1	Q8K0U4	30.7	641	583	675	3.06e-84	279	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007643	GN007643.1	Q6ZNB6	50.4	783	868	911	1.92e-240	701	NFXL1_HUMAN	NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP)	Homo sapiens (Human)		DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0000785; GO:0000977; GO:0000981; GO:0005634; GO:0008270; GO:0016020
GN007644	GN007644.1	Q05086	49.7	892	888	875	5.34e-285	814	UBE3A_HUMAN	Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)	Homo sapiens (Human)	brain development [GO:0007420]; Golgi lumen acidification [GO:0061795]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of protein ubiquitination [GO:0031398]; progesterone receptor signaling pathway [GO:0050847]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; regulation of circadian rhythm [GO:0042752]; regulation of synaptic plasticity [GO:0048167]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to progesterone [GO:0032570]; ubiquitin-dependent protein catabolic process [GO:0006511]	transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; synaptic vesicle [GO:0008021]	GO:0000209; GO:0003713; GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006511; GO:0007420; GO:0008021; GO:0031398; GO:0032570; GO:0042752; GO:0043161; GO:0048167; GO:0050847; GO:0051865; GO:0061630; GO:0061795; GO:0070936; GO:0098978; GO:0099524; GO:1904262; GO:2000058
GN007645	GN007645.1	O60264	77.6	994	1024	1052	0.0	1498	SMCA5_HUMAN	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; DNA-templated transcription initiation [GO:0006352]; negative regulation of mitotic chromosome condensation [GO:1905213]; negative regulation of transcription by RNA polymerase I [GO:0016479]; nucleosome assembly [GO:0006334]; positive regulation of DNA replication [GO:0045740]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; rDNA heterochromatin formation [GO:0000183]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated transcription [GO:0006355]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone octamer slider activity [GO:0140751]; nucleosome binding [GO:0031491]; protein-RNA adaptor activity [GO:0140517]	ACF complex [GO:0016590]; B-WICH complex [GO:0110016]; CERF complex [GO:0090537]; CHRAC [GO:0008623]; chromatin silencing complex [GO:0005677]; chromosome [GO:0005694]; condensed chromosome [GO:0000793]; fibrillar center [GO:0001650]; NoRC complex [GO:0090536]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]; pericentric heterochromatin [GO:0005721]; RSF complex [GO:0031213]; site of double-strand break [GO:0035861]; WICH complex [GO:0090535]	GO:0000183; GO:0000793; GO:0001650; GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005677; GO:0005694; GO:0005721; GO:0005730; GO:0006275; GO:0006281; GO:0006325; GO:0006334; GO:0006338; GO:0006346; GO:0006352; GO:0006355; GO:0006974; GO:0008623; GO:0016479; GO:0016589; GO:0016590; GO:0016887; GO:0031213; GO:0031491; GO:0035861; GO:0045740; GO:0045943; GO:0045944; GO:0045945; GO:0090535; GO:0090536; GO:0090537; GO:0110016; GO:0140374; GO:0140517; GO:0140658; GO:0140751; GO:1905213
GN007646	GN007646.1	Q566M8	38.0	334	424	419	2.86e-59	202	RN150_DANRE	RING finger protein 150	Danio rerio (Zebrafish) (Brachydanio rerio)	ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]	membrane [GO:0016020]	GO:0006511; GO:0016020; GO:0061630
GN007649	GN007649.1	Q6NSJ0	31.9	570	681	714	5.75e-94	309	MYORG_HUMAN	Alpha-galactosidase MYORG (EC 3.2.1.22) (Myogenesis regulating glycosidase) (Nuclear envelope transmembrane protein 37)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; skeletal muscle fiber development [GO:0048741]	alpha-galactosidase activity [GO:0004557]	endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]	GO:0004557; GO:0005789; GO:0005975; GO:0031965; GO:0043568; GO:0048741; GO:0051897
GN007650	GN007650.1	Q8R2H1	24.8	371	344	381	1.72e-12	71.2	IKBL1_RAT	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1)	Rattus norvegicus (Rat)	cellular response to lipopolysaccharide [GO:0071222]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]	transcription regulator inhibitor activity [GO:0140416]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0031665; GO:0032720; GO:0034122; GO:0043124; GO:0071222; GO:0140416
GN007651	GN007651.1	Q6PIJ6	33.5	1291	1272	1188	1.47e-175	555	FBX38_HUMAN	F-box only protein 38	Homo sapiens (Human)	positive regulation of neuron projection development [GO:0010976]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated immune response to tumor cell [GO:0002842]; protein K48-linked ubiquitination [GO:0070936]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0002842; GO:0005634; GO:0005737; GO:0005829; GO:0010976; GO:0019005; GO:0031146; GO:0050870; GO:0070936; GO:1990756
GN007652	GN007652.1	A0A345BJN8	34.5	145	352	919	5.27e-18	89.0	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN007655	GN007655.1	O88533	64.3	474	477	480	4.86e-229	640	DDC_MOUSE	Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC)	Mus musculus (Mouse)	aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; amino acid metabolic process [GO:0006520]; catecholamine metabolic process [GO:0006584]; dopamine biosynthetic process [GO:0042416]; gene expression [GO:0010467]; kidney development [GO:0001822]; response to toxic substance [GO:0009636]; serotonin biosynthetic process [GO:0042427]	5-hydroxy-L-tryptophan decarboxylase activity [GO:0036467]; amino acid binding [GO:0016597]; aromatic-L-amino-acid decarboxylase activity [GO:0004058]; enzyme binding [GO:0019899]; L-dopa decarboxylase activity [GO:0036468]; protein domain specific binding [GO:0019904]; pyridoxal phosphate binding [GO:0030170]	axon [GO:0030424]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; synaptic vesicle [GO:0008021]	GO:0001822; GO:0004058; GO:0005737; GO:0006520; GO:0006584; GO:0008021; GO:0009636; GO:0010467; GO:0015842; GO:0016597; GO:0019899; GO:0019904; GO:0030170; GO:0030424; GO:0036467; GO:0036468; GO:0042416; GO:0042427; GO:0043025
GN007657	GN007657.1	Q9UKM7	60.7	450	652	699	3.50e-199	579	MA1B1_HUMAN	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1)	Homo sapiens (Human)	endoplasmic reticulum mannose trimming [GO:1904380]; endoplasmic reticulum N-glycan trimming [GO:0140277]; ERAD pathway [GO:0036503]; oligosaccharide metabolic process [GO:0009311]; trimming of terminal mannose on C branch [GO:0036510]; viral protein processing [GO:0019082]	calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; extracellular vesicle [GO:1903561]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0004571; GO:0005509; GO:0005783; GO:0005789; GO:0005794; GO:0009311; GO:0016020; GO:0019082; GO:0031410; GO:0036503; GO:0036510; GO:0044322; GO:0140277; GO:1903561; GO:1904380
GN007659	GN007659.1	Q16956	85.5	648	661	667	0.0	1061	BIP_APLCA	Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (Immunoglobulin heavy chain-binding protein homolog) (BiP) (Protein 1603)	Aplysia californica (California sea hare)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	endoplasmic reticulum lumen [GO:0005788]	GO:0005524; GO:0005788; GO:0016887
GN007660	GN007660.1	P98164	24.0	975	1156	4655	1.23e-51	204	LRP2_HUMAN	Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)	Homo sapiens (Human)	amyloid-beta clearance [GO:0097242]; cellular response to growth factor stimulus [GO:0071363]; cobalamin transport [GO:0015889]; coronary artery morphogenesis [GO:0060982]; endocytosis [GO:0006897]; folate import across plasma membrane [GO:1904447]; lipid metabolic process [GO:0006629]; male gonad development [GO:0008584]; metal ion transport [GO:0030001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; neural tube closure [GO:0001843]; neuron projection arborization [GO:0140058]; outflow tract septum morphogenesis [GO:0003148]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of neurogenesis [GO:0050769]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; protein transport [GO:0015031]; pulmonary artery morphogenesis [GO:0061156]; receptor-mediated endocytosis [GO:0006898]; response to leptin [GO:0044321]; retinoid metabolic process [GO:0001523]; secondary heart field specification [GO:0003139]; sensory perception of sound [GO:0007605]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]; vagina development [GO:0060068]; ventricular compact myocardium morphogenesis [GO:0003223]; vitamin D metabolic process [GO:0042359]	calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; hormone binding [GO:0042562]; insulin-like growth factor I binding [GO:0031994]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-folding chaperone binding [GO:0051087]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; brush border membrane [GO:0031526]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001523; GO:0001843; GO:0003139; GO:0003148; GO:0003223; GO:0005041; GO:0005509; GO:0005764; GO:0005765; GO:0005783; GO:0005794; GO:0005886; GO:0005905; GO:0006629; GO:0006897; GO:0006898; GO:0007605; GO:0008584; GO:0009897; GO:0015031; GO:0015889; GO:0016324; GO:0030001; GO:0030424; GO:0030425; GO:0030514; GO:0030669; GO:0031526; GO:0031904; GO:0031994; GO:0038024; GO:0042359; GO:0042562; GO:0043066; GO:0043235; GO:0043491; GO:0044321; GO:0045056; GO:0050769; GO:0051087; GO:0060068; GO:0060982; GO:0061156; GO:0070062; GO:0070447; GO:0071363; GO:0097242; GO:0140058; GO:0150104; GO:1904447; GO:1905167
GN007672	GN007672.1	M9PH32	25.3	300	774	1206	6.58e-14	79.7	MEI26_DROME	Protein meiotic P26	Drosophila melanogaster (Fruit fly)	protein ubiquitination [GO:0016567]	ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]	GO:0004842; GO:0005737; GO:0008270; GO:0016567; GO:0036464
GN007677	GN007677.1	Q9W445	59.6	146	147	182	2.02e-62	192	MCTS1_DROME	Malignant T-cell-amplified sequence 1 homolog (Multiple copies in T-cell lymphoma 1 homolog) (MCT-1)	Drosophila melanogaster (Fruit fly)	formation of translation preinitiation complex [GO:0001731]; translation reinitiation [GO:0002188]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; protein-containing complex [GO:0032991]	GO:0001731; GO:0002188; GO:0003723; GO:0005737; GO:0032991
GN007679	GN007679.1	Q9DF58	65.4	477	474	452	3.99e-167	481	ILK_CHICK	Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK)	Gallus gallus (Chicken)	actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; caveola assembly [GO:0070836]; integrin-mediated signaling pathway [GO:0007229]; mitotic spindle organization [GO:0007052]; outflow tract morphogenesis [GO:0003151]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to cell cortex [GO:0072697]; substrate adhesion-dependent cell spreading [GO:0034446]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	ATP binding [GO:0005524]; integrin binding [GO:0005178]; magnesium ion binding [GO:0000287]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]	cell cortex [GO:0005938]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sarcomere [GO:0030017]	GO:0000287; GO:0000785; GO:0003151; GO:0004672; GO:0005178; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0005925; GO:0005938; GO:0007052; GO:0007229; GO:0019901; GO:0030017; GO:0030027; GO:0030513; GO:0033209; GO:0034446; GO:0043123; GO:0045669; GO:0045893; GO:0051017; GO:0051639; GO:0070836; GO:0072697; GO:0090263; GO:1900026
GN007680	GN007680.1	Q9CR16	65.8	225	227	370	1.72e-100	299	PPID_MOUSE	Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Rotamase D)	Mus musculus (Mouse)	cellular response to UV-A [GO:0071492]; lipid droplet organization [GO:0034389]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein secretion [GO:0050714]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein-containing complex assembly [GO:0065003]	cyclosporin A binding [GO:0016018]; enzyme binding [GO:0019899]; FK506 binding [GO:0005528]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; nuclear estrogen receptor binding [GO:0030331]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; transcription factor binding [GO:0008134]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0003755; GO:0005528; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0005929; GO:0006457; GO:0008134; GO:0016018; GO:0019899; GO:0030331; GO:0030544; GO:0031072; GO:0034389; GO:0043065; GO:0045070; GO:0050714; GO:0051879; GO:0065003; GO:0071492
GN007682	GN007682.1	P25153	89.3	150	156	151	3.94e-97	279	UBCD6_DROME	Ubiquitin-conjugating enzyme E2-17 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 6) (RAD6 homolog) (dRad6) (Ubiquitin carrier protein) (Ubiquitin-protein ligase)	Drosophila melanogaster (Fruit fly)	centrosome cycle [GO:0007098]; centrosome separation [GO:0051299]; DNA repair [GO:0006281]; endocytic recycling [GO:0032456]; heart development [GO:0007507]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of heterochromatin formation [GO:0031452]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitophagy [GO:1901526]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	p53 binding [GO:0002039]; protein domain specific binding [GO:0019904]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; HULC complex [GO:0033503]; nucleus [GO:0005634]	GO:0000209; GO:0002039; GO:0004842; GO:0005634; GO:0005737; GO:0006281; GO:0006511; GO:0007098; GO:0007507; GO:0019904; GO:0031452; GO:0032436; GO:0032456; GO:0033503; GO:0043066; GO:0043161; GO:0043518; GO:0045893; GO:0051299; GO:0061631; GO:0070373; GO:1901526; GO:1902166
GN007683	GN007683.1	Q5ZIF3	45.7	429	1076	460	1.07e-114	365	UFSP2_CHICK	Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-)	Gallus gallus (Chicken)	proteolysis [GO:0006508]; ribosome disassembly [GO:0032790]	deUFMylase activity [GO:0071567]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005783; GO:0006508; GO:0032790; GO:0071567
GN007684	GN007684.1	P08630	58.9	416	431	786	2.34e-169	497	BTKL_DROME	Tyrosine-protein kinase Btk (EC 2.7.10.2) (Dsrc28C) (Dsrc29a)	Drosophila melanogaster (Fruit fly)	actin cytoskeleton organization [GO:0030036]; cellularization [GO:0007349]; courtship behavior [GO:0007619]; determination of adult lifespan [GO:0008340]; DNA endoreduplication [GO:0042023]; dorsal closure [GO:0007391]; female germline ring canal formation [GO:0007301]; head involution [GO:0008258]; imaginal disc-derived male genitalia development [GO:0007485]; JNK cascade [GO:0007254]; oocyte karyosome formation [GO:0030717]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian fusome organization [GO:0030723]; ovarian nurse cell to oocyte transport [GO:0007300]; regulation of actin filament polymerization [GO:0030833]; salivary gland morphogenesis [GO:0007435]; sensitization [GO:0046960]; spiracle morphogenesis, open tracheal system [GO:0035277]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]	apical part of cell [GO:0045177]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; germline ring canal [GO:0045172]; plasma membrane [GO:0005886]	GO:0004713; GO:0004715; GO:0005524; GO:0005737; GO:0005886; GO:0007254; GO:0007300; GO:0007301; GO:0007349; GO:0007391; GO:0007424; GO:0007435; GO:0007485; GO:0007619; GO:0008258; GO:0008340; GO:0030036; GO:0030717; GO:0030723; GO:0030833; GO:0035277; GO:0042023; GO:0045172; GO:0045177; GO:0046960; GO:0048477; GO:0071944
GN007685	GN007685.1	Q08881	31.2	189	206	620	7.15e-21	93.2	ITK_HUMAN	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)	Homo sapiens (Human)	adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; cellular defense response [GO:0006968]; gamma-delta T cell activation [GO:0046629]; intracellular signal transduction [GO:0035556]; NK T cell differentiation [GO:0001865]; positive regulation of cytokine production [GO:0001819]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0001819; GO:0001865; GO:0002250; GO:0004715; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0006968; GO:0007165; GO:0035556; GO:0042110; GO:0046629; GO:0050852; GO:0050853
GN007686	GN007686.1	Q7PR68	55.3	217	219	219	2.01e-82	247	MED7_ANOGA	Mediator of RNA polymerase II transcription subunit 7 (Mediator complex subunit 7)	Anopheles gambiae (African malaria mosquito)	regulation of transcription by RNA polymerase II [GO:0006357]	transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]	GO:0003712; GO:0006357; GO:0016592; GO:0070847
GN007687	GN007687.1	Q6P1H6	38.6	601	1139	964	7.02e-110	369	ANKL2_MOUSE	Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4)	Mus musculus (Mouse)	central nervous system development [GO:0007417]; mitotic nuclear membrane reassembly [GO:0007084]; negative regulation of apoptotic process [GO:0043066]; negative regulation of phosphorylation [GO:0042326]	protein kinase inhibitor activity [GO:0004860]; protein phosphatase 2A binding [GO:0051721]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0004860; GO:0005783; GO:0005789; GO:0007084; GO:0007417; GO:0042326; GO:0043066; GO:0051721
GN007688	GN007688.1	Q9DBX3	30.7	743	1080	820	7.90e-90	310	SUSD2_MOUSE	Sushi domain-containing protein 2	Mus musculus (Mouse)	negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell division [GO:0051782]		plasma membrane [GO:0005886]	GO:0005886; GO:0051782; GO:1902807
GN007689	GN007689.1	H9JIQ1	26.5	948	873	1583	5.02e-76	275	MESH_BOMMO	Protein mesh	Bombyx mori (Silk moth)	cell-matrix adhesion [GO:0007160]		lateral plasma membrane [GO:0016328]; septate junction [GO:0005918]	GO:0005918; GO:0007160; GO:0016328
GN007690	GN007690.1	Q9HC56	34.3	708	721	1237	1.09e-103	347	PCDH9_HUMAN	Protocadherin-9	Homo sapiens (Human)	cell adhesion [GO:0007155]; forebrain development [GO:0030900]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0030900; GO:0050839; GO:0097060; GO:0098978
GN007695	GN007695.1	Q4KM84	45.2	217	286	362	2.15e-54	183	MET18_RAT	Histidine protein methyltransferase 1 homolog (EC 2.1.1.85) (Methyltransferase-like protein 18)	Rattus norvegicus (Rat)	peptidyl-lysine monomethylation [GO:0018026]; regulation of ribosome biogenesis [GO:0090069]; regulation of rRNA processing [GO:2000232]; regulation of translation [GO:0006417]; regulation of translational elongation [GO:0006448]	heat shock protein binding [GO:0031072]; protein-L-histidine N-tele-methyltransferase activity [GO:0018064]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0005634; GO:0005730; GO:0005829; GO:0006417; GO:0006448; GO:0018026; GO:0018064; GO:0031072; GO:0032991; GO:0090069; GO:2000232
GN007696	GN007696.1	Q6P5I8	55.8	258	279	257	8.33e-84	254	YIPF5_DANRE	Protein YIPF5 (YIP1 family member 5)	Danio rerio (Zebrafish) (Brachydanio rerio)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; vesicle fusion with Golgi apparatus [GO:0048280]		endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	GO:0005789; GO:0005794; GO:0006888; GO:0048280; GO:0060628
GN007697	GN007697.1	Q963B7	69.1	188	187	190	4.29e-88	259	RL9_SPOFR	Large ribosomal subunit protein uL6 (60S ribosomal protein L9)	Spodoptera frugiperda (Fall armyworm)	cytoplasmic translation [GO:0002181]	rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]	GO:0002181; GO:0003735; GO:0019843; GO:0022625
GN007704	GN007704.1	P26016	39.4	104	206	1269	2.32e-15	77.4	FUR11_DROME	Furin-like protease 1, isoforms 1/1-X/2 (Furin-1) (EC 3.4.21.75) (Kex2-like endoprotease 1) (dKLIP-1)	Drosophila melanogaster (Fruit fly)	glutamate receptor clustering [GO:0097688]; peptide hormone processing [GO:0016486]; postsynaptic membrane organization [GO:0001941]; presynaptic membrane organization [GO:0097090]; synaptic target recognition [GO:0008039]	serine-type endopeptidase activity [GO:0004252]	Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0001941; GO:0004252; GO:0005802; GO:0005886; GO:0008039; GO:0016486; GO:0097090; GO:0097688
GN007706	GN007706.1	Q8K0U4	32.2	643	596	675	9.77e-88	289	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007707	GN007707.1	Q8K0U4	30.4	586	538	675	1.52e-80	268	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007710	GN007710.1	Q502W6	32.7	1310	1874	1294	2.39e-201	641	VWA3B_HUMAN	von Willebrand factor A domain-containing protein 3B (VWA domain-containing protein 3B)	Homo sapiens (Human)			cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829
GN007711	GN007711.1	P35448	50.6	77	1020	1173	3.42e-14	81.3	TSP1_XENLA	Thrombospondin-1 (Glycoprotein G)	Xenopus laevis (African clawed frog)	cell adhesion [GO:0007155]; negative regulation of angiogenesis [GO:0016525]	calcium ion binding [GO:0005509]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; sarcoplasmic reticulum [GO:0016529]	GO:0005509; GO:0005576; GO:0005783; GO:0007155; GO:0009986; GO:0016525; GO:0016529; GO:0031012
GN007712	GN007712.1	Q6TFL4	39.0	408	612	600	6.47e-83	275	KLH24_HUMAN	Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1)	Homo sapiens (Human)	intermediate filament organization [GO:0045109]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	adherens junction [GO:0005912]; axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; perikaryon [GO:0043204]	GO:0005737; GO:0005912; GO:0016567; GO:0030057; GO:0030424; GO:0031463; GO:0043161; GO:0043204; GO:0045109; GO:0051865; GO:1990756
GN007713	GN007713.1	Q9CRB3	52.2	113	119	118	5.94e-29	104	HIUH_MOUSE	5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17) (Transthyretin-related protein)	Mus musculus (Mouse)	adenosine catabolic process [GO:0006154]; AMP catabolic process [GO:0006196]; dAMP catabolic process [GO:0046059]; deoxyadenosine catabolic process [GO:0006157]; deoxyguanosine catabolic process [GO:0006161]; deoxyinosine catabolic process [GO:0006149]; dGMP catabolic process [GO:0046055]; GMP catabolic process [GO:0046038]; guanine catabolic process [GO:0006147]; hypoxanthine catabolic process [GO:0009114]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; purine nucleobase metabolic process [GO:0006144]; urate catabolic process [GO:0019628]; xanthine catabolic process [GO:0009115]	hydrolase activity [GO:0016787]; hydroxyisourate hydrolase activity [GO:0033971]	mitochondrion [GO:0005739]; peroxisome [GO:0005777]	GO:0005739; GO:0005777; GO:0006144; GO:0006147; GO:0006148; GO:0006149; GO:0006154; GO:0006157; GO:0006161; GO:0006196; GO:0006204; GO:0009114; GO:0009115; GO:0016787; GO:0019628; GO:0033971; GO:0046038; GO:0046055; GO:0046059
GN007714	GN007714.1	Q9P2Z0	37.0	100	644	257	7.13e-11	66.6	THA10_HUMAN	THAP domain-containing protein 10	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]		GO:0043565
GN007716	GN007716.1	A0A345BJN8	27.6	304	533	919	2.15e-15	83.2	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN007720	GN007720.1	A2BFC9	37.5	240	261	240	2.59e-43	150	CFA77_DANRE	Cilia- and flagella-associated protein 77	Danio rerio (Zebrafish) (Brachydanio rerio)	integrin-mediated signaling pathway [GO:0007229]; positive regulation of focal adhesion assembly [GO:0051894]	GTPase activator activity [GO:0005096]	axoneme [GO:0005930]; cilium [GO:0005929]; dendrite [GO:0030425]; external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]	GO:0005096; GO:0005929; GO:0005930; GO:0007229; GO:0009897; GO:0030425; GO:0045121; GO:0051894
GN007723	GN007723.1	Q9Z2J0	50.0	570	597	605	2.02e-199	574	S23A1_MOUSE	Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (Yolk sac permease-like molecule 3)	Mus musculus (Mouse)	brain development [GO:0007420]; dehydroascorbic acid transport [GO:0070837]; L-ascorbic acid transmembrane transport [GO:0015882]; lung development [GO:0030324]; response to toxic substance [GO:0009636]; sodium ion transport [GO:0006814]	dehydroascorbic acid transmembrane transporter activity [GO:0033300]; L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]; sodium ion transmembrane transporter activity [GO:0015081]; urate transmembrane transporter activity [GO:0015143]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; brush border [GO:0005903]; cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0005903; GO:0006814; GO:0007420; GO:0008520; GO:0009636; GO:0009925; GO:0015081; GO:0015143; GO:0015229; GO:0015882; GO:0016324; GO:0030324; GO:0033300; GO:0043229; GO:0070837
GN007726	GN007726.1	Q60953	22.5	383	882	885	8.84e-16	85.9	PML_MOUSE	Protein PML	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular senescence [GO:0090398]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; oncogene-induced cell senescence [GO:0090402]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of peptidyl-lysine acetylation [GO:2000758]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of telomere maintenance [GO:0032206]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; protein-containing complex assembly [GO:0065003]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of MHC class I biosynthetic process [GO:0045343]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein signal transduction [GO:0060395]; suppression of viral release by host [GO:0044790]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cobalt ion binding [GO:0050897]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SMAD binding [GO:0046332]; SUMO binding [GO:0032183]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase activity [GO:0061659]; zinc ion binding [GO:0008270]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0000781; GO:0001666; GO:0002230; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005789; GO:0005829; GO:0006338; GO:0006355; GO:0006605; GO:0006606; GO:0006915; GO:0007179; GO:0008270; GO:0008285; GO:0008630; GO:0008631; GO:0009411; GO:0010332; GO:0010522; GO:0010761; GO:0016363; GO:0016525; GO:0016604; GO:0016605; GO:0019789; GO:0030099; GO:0030155; GO:0030308; GO:0030330; GO:0030578; GO:0031625; GO:0031901; GO:0031965; GO:0032183; GO:0032206; GO:0032211; GO:0032469; GO:0032691; GO:0032692; GO:0032922; GO:0032938; GO:0034097; GO:0042752; GO:0042771; GO:0042802; GO:0042803; GO:0043153; GO:0043161; GO:0044790; GO:0045087; GO:0045165; GO:0045343; GO:0045892; GO:0045930; GO:0046332; GO:0046982; GO:0048146; GO:0048384; GO:0050821; GO:0050897; GO:0051457; GO:0051726; GO:0060058; GO:0060090; GO:0060395; GO:0060444; GO:0061659; GO:0065003; GO:0070059; GO:0071353; GO:0072332; GO:0090398; GO:0090402; GO:0097191; GO:0140374; GO:1901798; GO:1904816; GO:1990830; GO:2000059; GO:2000758; GO:2000779; GO:2001235; GO:2001238
GN007728	GN007728.1	Q6GPB8	59.0	405	659	534	9.35e-175	511	DBR1A_XENLA	Lariat debranching enzyme A (EC 3.1.4.-)	Xenopus laevis (African clawed frog)	mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]	RNA lariat debranching enzyme activity [GO:0008419]	nucleus [GO:0005634]	GO:0000375; GO:0000398; GO:0005634; GO:0008419
GN007737	GN007737.1	Q9I8C7	44.5	308	486	452	5.10e-91	287	ACH10_CHICK	Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0050910; GO:0097060; GO:1902495
GN007738	GN007738.1	Q3T0L3	33.8	142	246	172	2.35e-13	69.3	RM17_BOVIN	Large ribosomal subunit protein bL17m (39S ribosomal protein L17, mitochondrial) (L17mt) (MRP-L17)	Bos taurus (Bovine)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]	GO:0003735; GO:0005743; GO:0005762; GO:0006412
GN007739	GN007739.1	P48181	26.3	316	412	493	3.83e-33	133	ACH2_CAEEL	Acetylcholine receptor subunit beta-type unc-29 (Uncoordinated protein 29)	Caenorhabditis elegans	calcium ion transport [GO:0006816]; locomotion [GO:0040011]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of locomotion involved in locomotory behavior [GO:0090326]; regulation of egg-laying behavior [GO:0046662]; regulation of membrane potential [GO:0042391]; regulation of muscle contraction [GO:0006937]; regulation of nematode pharyngeal pumping [GO:0043051]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0006937; GO:0007271; GO:0007274; GO:0014057; GO:0022848; GO:0030594; GO:0034220; GO:0040011; GO:0042391; GO:0043005; GO:0043025; GO:0043051; GO:0045202; GO:0045211; GO:0046662; GO:0090326
GN007741	GN007741.1	Q5XGG3	35.1	333	343	321	3.51e-48	167	PIHD2_XENTR	PIH1 domain-containing protein 2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	box C/D snoRNP assembly [GO:0000492]; rRNA processing [GO:0006364]		cytoplasm [GO:0005737]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]	GO:0000492; GO:0005737; GO:0006364; GO:0097255; GO:1990904
GN007744	GN007744.1	A5PN52	40.3	144	176	164	1.31e-18	81.3	HOATZ_DANRE	Cilia- and flagella-associated protein HOATZ	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]		cilium [GO:0005929]; cytoplasm [GO:0005737]	GO:0005737; GO:0005929; GO:0060271
GN007745	GN007745.1	A0A2B4RNI3	27.8	241	670	688	2.86e-18	92.8	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN007746	GN007746.1	O33752	41.8	91	128	133	5.66e-16	72.0	Y175_PICP2	Uncharacterized protein SYNPCC7002_A0175	Picosynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)				
GN007749	GN007749.1	Q8VHI5	29.2	253	719	650	4.19e-23	108	VITRN_MOUSE	Vitrin (Akhirin)	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]; spinal cord development [GO:0021510]	glycosaminoglycan binding [GO:0005539]	extracellular matrix [GO:0031012]; interstitial matrix [GO:0005614]	GO:0005539; GO:0005614; GO:0010811; GO:0021510; GO:0030198; GO:0031012
GN007750	GN007750.1	P50429	40.2	343	646	534	8.78e-81	268	ARSB_MOUSE	Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S)	Mus musculus (Mouse)	anterior head development [GO:0097065]; autophagy [GO:0006914]; chondroitin sulfate proteoglycan catabolic process [GO:0030207]; colon epithelial cell migration [GO:0061580]; dermatan sulfate proteoglycan catabolic process [GO:0030209]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268]	arylsulfatase activity [GO:0004065]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943]; N-acetylgalactosamine-6-sulfatase activity [GO:0043890]; sulfuric ester hydrolase activity [GO:0008484]	cell surface [GO:0009986]; lysosome [GO:0005764]	GO:0003943; GO:0004065; GO:0005764; GO:0006914; GO:0007584; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0030207; GO:0030209; GO:0043627; GO:0043890; GO:0051597; GO:0061580; GO:0097065
GN007755	GN007755.1	Q9P2Z0	38.0	100	360	257	8.32e-14	73.9	THA10_HUMAN	THAP domain-containing protein 10	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]		GO:0043565
GN007757	GN007757.1	P38571	50.0	382	419	399	2.31e-131	386	LICH_HUMAN	Lysosomal acid lipase/cholesteryl ester hydrolase (Acid cholesteryl ester hydrolase) (LAL) (EC 3.1.1.13) (Cholesteryl esterase) (Diacylglycerol lipase) (Lipase A) (Sterol esterase) (Triacylglycerol ester hydrolase) (Triacylglycerol lipase)	Homo sapiens (Human)	low-density lipoprotein particle clearance [GO:0034383]; sterol metabolic process [GO:0016125]	diacylglycerol lipase activity [GO:0120516]; lipase activity [GO:0016298]; sterol ester esterase activity [GO:0004771]; triacylglycerol lipase activity [GO:0004806]	lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	GO:0004771; GO:0004806; GO:0005764; GO:0016125; GO:0016298; GO:0034383; GO:0043202; GO:0120516
GN007758	GN007758.1	Q80VI1	21.0	747	648	734	3.22e-16	86.3	TRI56_MOUSE	E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (Tripartite motif-containing protein 56)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cGAS/STING signaling pathway [GO:0140896]; defense response to virus [GO:0051607]; host-mediated suppression of symbiont invasion [GO:0046597]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; response to type I interferon [GO:0034340]; suppression of viral release by host [GO:0044790]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0005829; GO:0006513; GO:0008270; GO:0032728; GO:0034340; GO:0044790; GO:0045087; GO:0045089; GO:0046597; GO:0051607; GO:0060340; GO:0061630; GO:0070534; GO:0140374; GO:0140896; GO:1901224
GN007759	GN007759.1	Q9UUA2	39.5	190	222	805	5.66e-28	114	PIF1_SCHPO	ATP-dependent DNA helicase pfh1 (EC 5.6.2.3) (DNA 5'-3' helicase pfh1) (DNA repair and recombination helicase pfh1) (PIF1 helicase homolog) (RRM3/PIF1 homolog 1)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand elongation involved in mitotic DNA replication [GO:1902983]; mitochondrial DNA repair [GO:0043504]; mitotic recombination-dependent replication fork processing [GO:1990426]; removal of RNA primer involved in mitotic DNA replication [GO:1903469]; replication fork processing [GO:0031297]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; 5'-3' DNA/RNA helicase activity [GO:0033678]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein-DNA complex displacement activity [GO:0061995]; DNA/DNA annealing activity [GO:1990814]; flap-structured DNA binding [GO:0070336]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex unwinding activity [GO:0160225]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]	chromatin [GO:0000785]; chromosome, telomeric repeat region [GO:0140445]; mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; nuclear replisome [GO:0043601]; nucleolus [GO:0005730]; nucleus [GO:0005634]; rDNA heterochromatin [GO:0033553]; site of double-strand break [GO:0035861]	GO:0000723; GO:0000785; GO:0003697; GO:0003723; GO:0005524; GO:0005634; GO:0005730; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0017116; GO:0031297; GO:0033553; GO:0033678; GO:0035861; GO:0043139; GO:0043504; GO:0043596; GO:0043601; GO:0051880; GO:0061995; GO:0070336; GO:0071932; GO:0140445; GO:0160225; GO:1902983; GO:1903469; GO:1990426; GO:1990814
GN007762	GN007762.1	Q60431	26.7	273	302	277	1.24e-14	75.9	CASP3_MESAU	Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]	Mesocricetus auratus (Golden hamster)	apoptotic process [GO:0006915]; erythrocyte differentiation [GO:0030218]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of neuron apoptotic process [GO:0043525]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; synapse pruning [GO:0098883]	cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]	cytoplasm [GO:0005737]; death-inducing signaling complex [GO:0031264]	GO:0004175; GO:0004197; GO:0005737; GO:0006508; GO:0006915; GO:0030182; GO:0030216; GO:0030218; GO:0031264; GO:0031647; GO:0043525; GO:0098883; GO:1902004
GN007764	GN007764.1	Q9WV60	80.4	388	733	420	2.17e-216	615	GSK3B_MOUSE	Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; autosome genomic imprinting [GO:0141068]; axonogenesis [GO:0007409]; bone remodeling [GO:0046849]; canonical Wnt signaling pathway [GO:0060070]; cell growth involved in cardiac muscle cell development [GO:0061049]; cell migration [GO:0016477]; cellular response to amyloid-beta [GO:1904646]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to interleukin-3 [GO:0036016]; cellular response to mechanical stimulus [GO:0071260]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; conditioned place preference [GO:1990708]; cytoplasmic translational initiation [GO:0002183]; cytoskeleton organization [GO:0007010]; epithelial to mesenchymal transition [GO:0001837]; ER overload response [GO:0006983]; establishment of cell polarity [GO:0030010]; establishment or maintenance of cell polarity [GO:0007163]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; glycogen metabolic process [GO:0005977]; hepatic stellate cell activation [GO:0035733]; hepatocyte apoptotic process [GO:0097284]; hippocampus development [GO:0021766]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; maintenance of cell polarity [GO:0030011]; meiosis I [GO:0007127]; mitochondrion organization [GO:0007005]; myoblast fusion [GO:0007520]; myotube differentiation [GO:0014902]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell migration [GO:0030336]; negative regulation of dendrite development [GO:2000171]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of gene expression [GO:0010629]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of mesenchymal stem cell differentiation [GO:2000740]; negative regulation of neuron maturation [GO:0014043]; negative regulation of neuron migration [GO:2001223]; negative regulation of neuron projection development [GO:0010977]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein localization to centrosome [GO:1904780]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of synaptic assembly at neuromuscular junction [GO:0045886]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC2 signaling [GO:1903940]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neuron projection development [GO:0031175]; neuron projection organization [GO:0106027]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphorylation [GO:0016310]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of axon extension [GO:0045773]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cilium assembly [GO:0045724]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of osteoclast proliferation [GO:0090290]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein localization to centrosome [GO:1904781]; positive regulation of protein localization to cilium [GO:1903566]; positive regulation of protein processing [GO:0010954]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of synaptic assembly at neuromuscular junction [GO:0045887]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of type I interferon production [GO:0032481]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein export from nucleus [GO:0006611]; protein localization to microtubule [GO:0035372]; protein phosphorylation [GO:0006468]; re-entry into mitotic cell cycle [GO:0000320]; regulation of apoptotic process [GO:0042981]; regulation of axon extension [GO:0030516]; regulation of axonogenesis [GO:0050770]; regulation of cell growth [GO:0001558]; regulation of circadian rhythm [GO:0042752]; regulation of dendrite morphogenesis [GO:0048814]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of microtubule anchoring at centrosome [GO:0150101]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule-based process [GO:0032886]; regulation of mitotic cell cycle [GO:0007346]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of neuron projection development [GO:0010975]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of osteoblast differentiation [GO:0045667]; regulation of protein export from nucleus [GO:0046825]; regulation of protein localization [GO:0032880]; response to endoplasmic reticulum stress [GO:0034976]; response to methamphetamine hydrochloride [GO:1904313]; response to zinc ion [GO:0010043]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; superior temporal gyrus development [GO:0071109]; TORC2 signaling [GO:0038203]; Wnt signaling pathway [GO:0016055]	ATP binding [GO:0005524]; beta-catenin binding [GO:0008013]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; integrin binding [GO:0005178]; ionotropic glutamate receptor binding [GO:0035255]; kinase activity [GO:0016301]; NF-kappaB binding [GO:0051059]; p53 binding [GO:0002039]; protease binding [GO:0002020]; protein kinase A catalytic subunit binding [GO:0034236]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase binding [GO:0120283]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; scaffold protein binding [GO:0097110]; tau protein binding [GO:0048156]; tau-protein kinase activity [GO:0050321]; ubiquitin protein ligase binding [GO:0031625]	axon [GO:0030424]; beta-catenin destruction complex [GO:0030877]; cell body [GO:0044297]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; meiotic spindle [GO:0072687]; membrane [GO:0016020]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; Schaffer collateral - CA1 synapse [GO:0098685]; Wnt signalosome [GO:1990909]	GO:0000082; GO:0000320; GO:0001558; GO:0001837; GO:0001954; GO:0002020; GO:0002039; GO:0002183; GO:0004672; GO:0004674; GO:0005178; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005874; GO:0005886; GO:0005977; GO:0006468; GO:0006611; GO:0006983; GO:0007005; GO:0007010; GO:0007127; GO:0007163; GO:0007346; GO:0007409; GO:0007520; GO:0007623; GO:0008013; GO:0008286; GO:0009887; GO:0010043; GO:0010508; GO:0010614; GO:0010628; GO:0010629; GO:0010719; GO:0010800; GO:0010918; GO:0010954; GO:0010975; GO:0010977; GO:0014043; GO:0014069; GO:0014902; GO:0016020; GO:0016055; GO:0016301; GO:0016310; GO:0016477; GO:0018105; GO:0019901; GO:0021766; GO:0030010; GO:0030011; GO:0030335; GO:0030336; GO:0030424; GO:0030425; GO:0030426; GO:0030516; GO:0030877; GO:0031146; GO:0031175; GO:0031333; GO:0031334; GO:0031398; GO:0031625; GO:0031663; GO:0032007; GO:0032435; GO:0032436; GO:0032481; GO:0032880; GO:0032886; GO:0032991; GO:0033690; GO:0034236; GO:0034392; GO:0034452; GO:0034976; GO:0035255; GO:0035372; GO:0035556; GO:0035729; GO:0035733; GO:0036016; GO:0038203; GO:0042752; GO:0042981; GO:0043025; GO:0043065; GO:0043066; GO:0043161; GO:0043197; GO:0043198; GO:0043407; GO:0043491; GO:0043525; GO:0044297; GO:0045444; GO:0045597; GO:0045667; GO:0045668; GO:0045672; GO:0045719; GO:0045724; GO:0045727; GO:0045732; GO:0045773; GO:0045879; GO:0045886; GO:0045887; GO:0045944; GO:0046627; GO:0046777; GO:0046825; GO:0046827; GO:0046849; GO:0048156; GO:0048168; GO:0048471; GO:0048661; GO:0048814; GO:0050321; GO:0050770; GO:0050774; GO:0051001; GO:0051059; GO:0051897; GO:0060070; GO:0061049; GO:0061629; GO:0070059; GO:0070507; GO:0070840; GO:0070885; GO:0071109; GO:0071260; GO:0071300; GO:0071385; GO:0072687; GO:0090090; GO:0090290; GO:0097110; GO:0097191; GO:0097192; GO:0097284; GO:0098685; GO:0098696; GO:0098793; GO:0098978; GO:0099159; GO:0099171; GO:0106027; GO:0106310; GO:0120283; GO:0141068; GO:0150101; GO:1900026; GO:1900181; GO:1900271; GO:1901030; GO:1902042; GO:1903566; GO:1903940; GO:1904313; GO:1904339; GO:1904646; GO:1904780; GO:1904781; GO:1990708; GO:1990904; GO:1990909; GO:2000059; GO:2000171; GO:2000463; GO:2000573; GO:2000727; GO:2000738; GO:2000740; GO:2001223
GN007765	GN007765.1	M0R3Q7	29.6	801	810	905	4.54e-98	328	PTHD3_RAT	Patched domain-containing protein 3	Rattus norvegicus (Rat)			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sperm midpiece [GO:0097225]	GO:0005783; GO:0005789; GO:0016020; GO:0097225
GN007767	GN007767.1	M0R3Q7	29.3	854	854	905	4.56e-100	335	PTHD3_RAT	Patched domain-containing protein 3	Rattus norvegicus (Rat)			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sperm midpiece [GO:0097225]	GO:0005783; GO:0005789; GO:0016020; GO:0097225
GN007774	GN007774.1	M0R3Q7	32.3	356	451	905	1.19e-52	193	PTHD3_RAT	Patched domain-containing protein 3	Rattus norvegicus (Rat)			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sperm midpiece [GO:0097225]	GO:0005783; GO:0005789; GO:0016020; GO:0097225
GN007777	GN007777.1	M0R3Q7	28.6	406	390	905	1.37e-35	142	PTHD3_RAT	Patched domain-containing protein 3	Rattus norvegicus (Rat)			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sperm midpiece [GO:0097225]	GO:0005783; GO:0005789; GO:0016020; GO:0097225
GN007778	GN007778.1	Q6NX28	73.8	164	331	308	1.77e-30	120	LRC59_XENTR	Leucine-rich repeat-containing protein 59	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]	GO:0005635; GO:0005789
GN007779	GN007779.1	Q9VF08	53.6	112	191	141	9.88e-33	117	TIM16_DROME	Mitochondrial import inner membrane translocase subunit Tim16 (Protein black pearl)	Drosophila melanogaster (Fruit fly)	protein import into mitochondrial matrix [GO:0030150]		mitochondrial matrix [GO:0005759]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	GO:0005744; GO:0005759; GO:0030150
GN007780	GN007780.1	Q8K0U4	30.4	526	487	675	8.32e-66	227	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN007782	GN007782.1	Q61687	48.6	218	284	2476	1.44e-56	199	ATRX_MOUSE	Chromatin remodeler ATRX (EC 3.6.4.-) (HP1 alpha-interacting protein) (HP1-BP38 protein) (Heterochromatin protein 2) (Transcriptional regulator ATRX) (X-linked nuclear protein)	Mus musculus (Mouse)	cellular response to hydroxyurea [GO:0072711]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; forebrain development [GO:0030900]; meiotic spindle organization [GO:0000212]; multicellular organism growth [GO:0035264]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; nucleosome assembly [GO:0006334]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic forelimb morphogenesis [GO:0035128]; protein localization to chromosome, telomeric region [GO:0070198]; replication fork processing [GO:0031297]; seminiferous tubule development [GO:0072520]; Sertoli cell development [GO:0060009]; spermatogenesis [GO:0007283]; subtelomeric heterochromatin formation [GO:0031509]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; chromo shadow domain binding [GO:0070087]; DNA translocase activity [GO:0015616]; histone binding [GO:0042393]; histone H3K9me2/3 reader activity [GO:0062072]	chromosome, subtelomeric region [GO:0099115]; chromosome, telomeric region [GO:0000781]; condensed chromosome, centromeric region [GO:0000779]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; PML body [GO:0016605]	GO:0000212; GO:0000228; GO:0000779; GO:0000781; GO:0000792; GO:0003682; GO:0005524; GO:0005634; GO:0005654; GO:0005721; GO:0006325; GO:0006334; GO:0006338; GO:0007283; GO:0010571; GO:0015616; GO:0016604; GO:0016605; GO:0016887; GO:0030330; GO:0030900; GO:0031297; GO:0031490; GO:0031509; GO:0032206; GO:0035128; GO:0035264; GO:0042393; GO:0045944; GO:0060009; GO:0062072; GO:0070087; GO:0070192; GO:0070198; GO:0072520; GO:0072711; GO:0099115; GO:0140658; GO:1904908
GN007783	GN007783.1	P46100	55.2	889	1312	2492	1.47e-254	796	ATRX_HUMAN	Chromatin remodeler ATRX (EC 3.6.4.-) (Transcriptional regulator ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)	Homo sapiens (Human)	cellular response to hydroxyurea [GO:0072711]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of DNA-templated transcription [GO:0006355]; replication fork processing [GO:0031297]; subtelomeric heterochromatin formation [GO:0031509]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; chromo shadow domain binding [GO:0070087]; histone binding [GO:0042393]; histone H3K9me2/3 reader activity [GO:0062072]	chromosome, subtelomeric region [GO:0099115]; chromosome, telomeric region [GO:0000781]; condensed chromosome, centromeric region [GO:0000779]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; PML body [GO:0016605]	GO:0000228; GO:0000779; GO:0000781; GO:0000792; GO:0003682; GO:0005524; GO:0005634; GO:0005654; GO:0005721; GO:0006325; GO:0006338; GO:0006355; GO:0010571; GO:0016604; GO:0016605; GO:0016887; GO:0030330; GO:0031297; GO:0031490; GO:0031509; GO:0032206; GO:0042393; GO:0045944; GO:0062072; GO:0070087; GO:0070198; GO:0072711; GO:0099115; GO:0140658; GO:1904908
GN007786	GN007786.1	Q08CG8	44.0	100	119	448	2.88e-21	90.5	RNF44_DANRE	RING finger protein 44	Danio rerio (Zebrafish) (Brachydanio rerio)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]		GO:0016567; GO:0061630
GN007790	GN007790.1	P50430	53.2	436	416	528	2.03e-165	478	ARSB_RAT	Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S)	Rattus norvegicus (Rat)	anterior head development [GO:0097065]; autophagy [GO:0006914]; chondroitin sulfate proteoglycan catabolic process [GO:0030207]; colon epithelial cell migration [GO:0061580]; dermatan sulfate proteoglycan catabolic process [GO:0030209]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268]	arylsulfatase activity [GO:0004065]; N-acetylgalactosamine-4-sulfatase activity [GO:0003943]; N-acetylgalactosamine-6-sulfatase activity [GO:0043890]; sulfuric ester hydrolase activity [GO:0008484]	cell surface [GO:0009986]; lysosome [GO:0005764]	GO:0003943; GO:0004065; GO:0005764; GO:0006914; GO:0007584; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0030207; GO:0030209; GO:0043627; GO:0043890; GO:0051597; GO:0061580; GO:0097065
GN007791	GN007791.1	P15364	32.2	236	326	333	9.49e-32	124	AMAL_DROME	Protein amalgam	Drosophila melanogaster (Fruit fly)	heterophilic cell-cell adhesion [GO:0007157]; maintenance of blood-brain barrier [GO:0035633]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of glial cell migration [GO:1903977]; positive regulation of glial cell proliferation [GO:0060252]	receptor ligand activity [GO:0048018]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005576; GO:0005886; GO:0007157; GO:0035633; GO:0045742; GO:0048018; GO:0060252; GO:1903977
GN007793	GN007793.1	E9PTT0	30.7	228	524	622	9.48e-18	90.1	ZDH17_RAT	Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 17)	Rattus norvegicus (Rat)	axonogenesis [GO:0007409]; lipoprotein transport [GO:0042953]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of modification of synapse structure, modulating synaptic transmission [GO:0098987]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]; regulation of programmed cell death [GO:0043067]	identical protein binding [GO:0042802]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; signaling receptor binding [GO:0005102]	cytoplasmic vesicle membrane [GO:0030659]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; perforant pathway to dendrate granule cell synapse [GO:0140240]; postsynaptic Golgi apparatus [GO:0150051]; presynaptic membrane [GO:0042734]	GO:0000139; GO:0005102; GO:0005794; GO:0007409; GO:0016409; GO:0018230; GO:0018345; GO:0019705; GO:0019706; GO:0030659; GO:0030660; GO:0042734; GO:0042802; GO:0042953; GO:0043067; GO:0051386; GO:0070372; GO:0098978; GO:0098987; GO:0140240; GO:0140439; GO:0150051
GN007799	GN007799.1	Q7ZW00	35.3	431	434	422	2.66e-73	239	AGK_DANRE	Acylglycerol kinase, mitochondrial (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) (MuLK) (Multi-substrate lipid kinase)	Danio rerio (Zebrafish) (Brachydanio rerio)	ceramide biosynthetic process [GO:0046513]; glycerolipid metabolic process [GO:0046486]; protein insertion into mitochondrial inner membrane [GO:0045039]; sphingosine biosynthetic process [GO:0046512]	acylglycerol kinase activity [GO:0047620]; ATP-dependent diacylglycerol kinase activity [GO:0004143]; ceramide kinase activity [GO:0001729]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]	GO:0001729; GO:0004143; GO:0005739; GO:0005743; GO:0005758; GO:0005886; GO:0031966; GO:0042721; GO:0045039; GO:0046486; GO:0046512; GO:0046513; GO:0047620
GN007800	GN007800.1	Q9H8L6	31.0	100	142	949	2.00e-10	60.8	MMRN2_HUMAN	Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit)	Homo sapiens (Human)	angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration [GO:0030336]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of defense response to bacterium [GO:1900426]; positive regulation of epithelial tube formation [GO:1905278]; positive regulation of morphogenesis of an epithelium [GO:1905332]	receptor ligand activity [GO:0048018]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; multimerin complex [GO:1990972]; non-collagenous component of basement membrane [GO:0140144]	GO:0001525; GO:0002042; GO:0005576; GO:0005788; GO:0007155; GO:0008285; GO:0030336; GO:0030948; GO:0031012; GO:0048018; GO:0070062; GO:0090051; GO:0140144; GO:1900426; GO:1903588; GO:1905278; GO:1905332; GO:1990972
GN007801	GN007801.1	Q9UBQ7	70.3	91	95	328	1.12e-35	126	GRHPR_HUMAN	Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81)	Homo sapiens (Human)	dicarboxylic acid metabolic process [GO:0043648]; glyoxylate metabolic process [GO:0046487]	carboxylic acid binding [GO:0031406]; glyoxylate reductase (NADPH) activity [GO:0030267]; hydroxypyruvate reductase (NADH) activity [GO:0008465]; hydroxypyruvate reductase (NADPH) activity [GO:0120509]; hydroxypyruvate reductase [NAD(P)H] activity [GO:0016618]; NAD binding [GO:0051287]; NADPH binding [GO:0070402]; protein homodimerization activity [GO:0042803]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]	GO:0005737; GO:0005739; GO:0005782; GO:0005829; GO:0008465; GO:0016618; GO:0030267; GO:0031406; GO:0042803; GO:0043648; GO:0046487; GO:0051287; GO:0070062; GO:0070402; GO:0120509; GO:1902494
GN007802	GN007802.1	P70582	54.1	399	534	510	5.15e-135	404	NUP54_RAT	Nuclear pore complex protein Nup54 (54 kDa nucleoporin) (Nucleoporin Nup54)	Rattus norvegicus (Rat)	NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein localization to nuclear inner membrane [GO:0036228]; protein targeting [GO:0006605]; regulation of protein import into nucleus [GO:0042306]	identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; structural constituent of nuclear pore [GO:0017056]	nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; protein-containing complex [GO:0032991]	GO:0005635; GO:0005643; GO:0006605; GO:0006607; GO:0006913; GO:0006999; GO:0017056; GO:0031965; GO:0032991; GO:0036228; GO:0042306; GO:0042802; GO:0044613; GO:0044877
GN007806	GN007806.1	Q8R3S6	49.3	919	895	894	2.84e-286	818	EXOC1_MOUSE	Exocyst complex component 1 (Exocyst complex component Sec3)	Mus musculus (Mouse)	embryo implantation [GO:0007566]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0000145; GO:0000281; GO:0005546; GO:0005737; GO:0005829; GO:0005886; GO:0006887; GO:0006893; GO:0006904; GO:0007566; GO:0048471; GO:0090148; GO:0090522; GO:0090543
GN007808	GN007808.1	Q17RB8	35.3	764	769	773	4.69e-143	442	LONF1_HUMAN	LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191)	Homo sapiens (Human)		metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]	GO:0005829; GO:0046872; GO:0061630
GN007809	GN007809.1	Q9GZQ3	35.8	151	176	224	7.78e-29	109	COMD5_HUMAN	COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG)	Homo sapiens (Human)	endocytic recycling [GO:0032456]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0005634; GO:0005654; GO:0005737; GO:0005789; GO:0005829; GO:0010008; GO:0032456; GO:0032991
GN007815	GN007815.1	A2ANX9	26.1	356	1025	761	5.97e-09	63.9	ZN711_MOUSE	Zinc finger protein 711	Mus musculus (Mouse)	germ cell development [GO:0007281]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0000978; GO:0003700; GO:0005634; GO:0006357; GO:0007281; GO:0008270; GO:0043565; GO:0045893; GO:0045944
GN007819	GN007819.1	P49247	61.4	233	235	311	2.04e-95	284	RPIA_HUMAN	Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase)	Homo sapiens (Human)	D-ribose metabolic process [GO:0006014]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]	identical protein binding [GO:0042802]; monosaccharide binding [GO:0048029]; ribose-5-phosphate isomerase activity [GO:0004751]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0004751; GO:0005737; GO:0005739; GO:0005829; GO:0006014; GO:0006098; GO:0009052; GO:0042802; GO:0048029
GN007820	GN007820.1	Q5I7G2	36.3	336	487	436	5.96e-64	216	RXR_LYMST	Retinoic acid receptor RXR (Retinoid X receptor) (LymRXR)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)		nuclear steroid receptor activity [GO:0003707]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; growth cone [GO:0030426]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0003707; GO:0005634; GO:0005737; GO:0008270; GO:0016020; GO:0030426; GO:0043565
GN007821	GN007821.1	Q7TM99	24.9	623	696	508	3.19e-43	166	MOT9_MOUSE	Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9)	Mus musculus (Mouse)	carboxylic acid transmembrane transport [GO:1905039]; carnitine transmembrane transport [GO:1902603]; creatine transmembrane transport [GO:0015881]; urate metabolic process [GO:0046415]	carnitine transmembrane transporter activity [GO:0015226]; creatine transmembrane transporter activity [GO:0005308]; monocarboxylic acid transmembrane transporter activity [GO:0008028]	plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0008028; GO:0015226; GO:0015881; GO:0046415; GO:1902603; GO:1905039
GN007822	GN007822.1	Q400C7	36.5	255	324	359	2.20e-46	163	AMZ2_RAT	Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2)	Rattus norvegicus (Rat)	proteolysis [GO:0006508]	metallopeptidase activity [GO:0008237]	nucleoplasm [GO:0005654]	GO:0005654; GO:0006508; GO:0008237
GN007823	GN007823.1	Q91ZD4	51.4	516	562	521	2.56e-137	411	VANG2_MOUSE	Vang-like protein 2 (Loop-tail protein 1) (Loop-tail-associated protein) (Van Gogh-like protein 2)	Mus musculus (Mouse)	anterior/posterior pattern specification [GO:0009952]; apical protein localization [GO:0045176]; branching involved in blood vessel morphogenesis [GO:0001569]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cell migration involved in kidney development [GO:0035787]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; convergent extension involved in axis elongation [GO:0060028]; convergent extension involved in neural plate elongation [GO:0022007]; convergent extension involved in organogenesis [GO:0060029]; digestive tract morphogenesis [GO:0048546]; dopaminergic neuron axon guidance [GO:0036514]; epicardial cell to mesenchymal cell transition [GO:0003347]; establishment of body hair planar orientation [GO:0048105]; establishment of epithelial cell polarity [GO:0090162]; establishment of planar polarity [GO:0001736]; establishment of planar polarity involved in neural tube closure [GO:0090177]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; glomerulus development [GO:0032835]; hair follicle development [GO:0001942]; heart looping [GO:0001947]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; inner ear receptor cell development [GO:0060119]; inner ear receptor cell stereocilium organization [GO:0060122]; kidney morphogenesis [GO:0060993]; lateral sprouting involved in lung morphogenesis [GO:0060490]; membranous septum morphogenesis [GO:0003149]; muscular septum morphogenesis [GO:0003150]; neural tube closure [GO:0001843]; non-canonical Wnt signaling pathway [GO:0035567]; non-motile cilium assembly [GO:1905515]; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060488]; outflow tract septum morphogenesis [GO:0003148]; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060489]; positive regulation of JUN kinase activity [GO:0043507]; post-anal tail morphogenesis [GO:0036342]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of establishment of planar polarity [GO:0090175]; regulation of synapse pruning [GO:1905806]; regulation of Wnt signaling pathway [GO:0030111]; Rho protein signal transduction [GO:0007266]; serotonergic neuron axon guidance [GO:0036515]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing [GO:0042060]		apical cytoplasm [GO:0090651]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]; cell pole [GO:0060187]; cell-cell junction [GO:0005911]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; glutamatergic synapse [GO:0098978]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; stress fiber [GO:0001725]	GO:0001569; GO:0001725; GO:0001736; GO:0001843; GO:0001942; GO:0001947; GO:0003148; GO:0003149; GO:0003150; GO:0003347; GO:0005886; GO:0005911; GO:0007266; GO:0009952; GO:0015012; GO:0016020; GO:0016323; GO:0016324; GO:0016328; GO:0022007; GO:0030111; GO:0030134; GO:0032835; GO:0032956; GO:0035019; GO:0035567; GO:0035787; GO:0036342; GO:0036514; GO:0036515; GO:0042060; GO:0043507; GO:0045176; GO:0045197; GO:0048103; GO:0048105; GO:0048546; GO:0060028; GO:0060029; GO:0060071; GO:0060119; GO:0060122; GO:0060187; GO:0060488; GO:0060489; GO:0060490; GO:0060947; GO:0060993; GO:0071944; GO:0090102; GO:0090103; GO:0090162; GO:0090175; GO:0090177; GO:0090651; GO:0098839; GO:0098978; GO:1905515; GO:1905806
GN007837	GN007837.1	A0A140LIJ0	25.9	371	944	701	1.28e-28	126	DCST2_MOUSE	DC-STAMP domain-containing protein 2	Mus musculus (Mouse)	fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; sperm-egg recognition [GO:0035036]		acrosomal membrane [GO:0002080]	GO:0002080; GO:0007342; GO:0035036
GN007838	GN007838.1	Q7ZYF1	35.3	207	242	273	1.43e-38	138	DJ27A_XENLA	DnaJ homolog subfamily C member 27-A (Rab and DnaJ domain-containing protein 1) (Rab and DnaJ domain-containing protein A)	Xenopus laevis (African clawed frog)	phagosome-lysosome fusion [GO:0090385]; vesicle-mediated transport [GO:0016192]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	late endosome [GO:0005770]; lysosome [GO:0005764]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]	GO:0003924; GO:0005525; GO:0005634; GO:0005764; GO:0005770; GO:0016192; GO:0045335; GO:0090385
GN007839	GN007839.1	Q9WZV3	50.0	62	216	369	6.90e-10	61.2	DNAJ_THEMA	Chaperone protein DnaJ	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	protein refolding [GO:0042026]; response to heat [GO:0009408]	ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005524; GO:0005737; GO:0008270; GO:0009408; GO:0031072; GO:0042026
GN007841	GN007841.1	Q9Z1L4	39.7	121	906	224	5.25e-20	93.2	XLRS1_MOUSE	Retinoschisin (X-linked juvenile retinoschisis protein homolog)	Mus musculus (Mouse)	protein homooligomerization [GO:0051260]; retina layer formation [GO:0010842]; visual perception [GO:0007601]	phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; phosphatidylserine binding [GO:0001786]; protein-containing complex binding [GO:0044877]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; neuron to neuron synapse [GO:0098984]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]	GO:0001786; GO:0001917; GO:0005546; GO:0005547; GO:0005576; GO:0005886; GO:0007601; GO:0009897; GO:0009986; GO:0010314; GO:0010842; GO:0032266; GO:0043325; GO:0044877; GO:0051260; GO:0070273; GO:0080025; GO:0098984
GN007842	GN007842.1	P51538	38.2	437	451	503	2.74e-94	296	CP3A9_RAT	Cytochrome P450 3A9 (EC 1.14.14.1) (3AH15) (CYPIIIA9) (Cytochrome P450 olfactive 3) (Cytochrome P450-OLF3)	Rattus norvegicus (Rat)	alkaloid catabolic process [GO:0009822]; estrogen metabolic process [GO:0008210]; female pregnancy [GO:0007565]; lipid hydroxylation [GO:0002933]; oxidative demethylation [GO:0070989]; positive regulation of gene expression [GO:0010628]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to zinc ion [GO:0010043]; retinoic acid metabolic process [GO:0042573]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic transport [GO:0042908]	estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]	endoplasmic reticulum membrane [GO:0005789]	GO:0002933; GO:0004497; GO:0005506; GO:0005789; GO:0007565; GO:0008202; GO:0008210; GO:0008395; GO:0008401; GO:0009822; GO:0010043; GO:0010628; GO:0016491; GO:0016712; GO:0020037; GO:0032355; GO:0042178; GO:0042573; GO:0042908; GO:0043627; GO:0045471; GO:0050649; GO:0070989; GO:0071548; GO:0101020; GO:0101021
GN007846	GN007846.1	Q27433	68.4	266	268	481	1.77e-119	353	MEC2_CAEEL	Mechanosensory protein 2	Caenorhabditis elegans	detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; mechanosensory behavior [GO:0007638]; positive regulation of detection of mechanical stimulus involved in sensory perception of touch [GO:1905789]; positive regulation of mechanosensory behavior [GO:1905792]; response to mechanical stimulus [GO:0009612]	cholesterol binding [GO:0015485]; ion channel inhibitor activity [GO:0008200]	neuron projection [GO:0043005]; neuron projection membrane [GO:0032589]; plasma membrane [GO:0005886]	GO:0005886; GO:0007638; GO:0008200; GO:0009612; GO:0015485; GO:0032589; GO:0043005; GO:0050976; GO:1905789; GO:1905792
GN007849	GN007849.1	Q27433	71.4	269	266	481	2.19e-122	360	MEC2_CAEEL	Mechanosensory protein 2	Caenorhabditis elegans	detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; mechanosensory behavior [GO:0007638]; positive regulation of detection of mechanical stimulus involved in sensory perception of touch [GO:1905789]; positive regulation of mechanosensory behavior [GO:1905792]; response to mechanical stimulus [GO:0009612]	cholesterol binding [GO:0015485]; ion channel inhibitor activity [GO:0008200]	neuron projection [GO:0043005]; neuron projection membrane [GO:0032589]; plasma membrane [GO:0005886]	GO:0005886; GO:0007638; GO:0008200; GO:0009612; GO:0015485; GO:0032589; GO:0043005; GO:0050976; GO:1905789; GO:1905792
GN007850	GN007850.1	Q27433	67.8	267	285	481	1.13e-122	362	MEC2_CAEEL	Mechanosensory protein 2	Caenorhabditis elegans	detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; mechanosensory behavior [GO:0007638]; positive regulation of detection of mechanical stimulus involved in sensory perception of touch [GO:1905789]; positive regulation of mechanosensory behavior [GO:1905792]; response to mechanical stimulus [GO:0009612]	cholesterol binding [GO:0015485]; ion channel inhibitor activity [GO:0008200]	neuron projection [GO:0043005]; neuron projection membrane [GO:0032589]; plasma membrane [GO:0005886]	GO:0005886; GO:0007638; GO:0008200; GO:0009612; GO:0015485; GO:0032589; GO:0043005; GO:0050976; GO:1905789; GO:1905792
GN007852	GN007852.1	Q16TM5	69.8	278	281	297	9.61e-127	365	BND7A_AEDAE	Band 7 protein AAEL010189	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)			plasma membrane [GO:0005886]	GO:0005886
GN007854	GN007854.1	P86854	32.6	144	396	156	2.36e-18	84.7	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN007855	GN007855.1	Q9EPW9	36.7	147	396	795	3.66e-19	93.2	TLR6_MOUSE	Toll-like receptor 6 (CD antigen CD286)	Mus musculus (Mouse)	antibacterial innate immune response [GO:0140367]; cellular response to amyloid-beta [GO:1904646]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; detection of diacyl bacterial lipopeptide [GO:0042496]; inflammatory response [GO:0006954]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide metabolic process [GO:0046209]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of macrophage activation [GO:0043032]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; response to bacterial lipoprotein [GO:0032493]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	diacyl lipopeptide binding [GO:0042498]; identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; lipopolysaccharide immune receptor activity [GO:0001875]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	GO:0001774; GO:0001875; GO:0002224; GO:0002755; GO:0004888; GO:0005102; GO:0005794; GO:0005886; GO:0006954; GO:0010628; GO:0030670; GO:0032493; GO:0032717; GO:0032720; GO:0032731; GO:0032735; GO:0032755; GO:0034136; GO:0035355; GO:0035663; GO:0035666; GO:0038023; GO:0038124; GO:0042496; GO:0042498; GO:0042802; GO:0043032; GO:0043123; GO:0043235; GO:0043507; GO:0045121; GO:0045429; GO:0046209; GO:0046982; GO:0050729; GO:0071723; GO:0071726; GO:0140052; GO:0140367; GO:1900017; GO:1900227; GO:1903428; GO:1904646; GO:2001238
GN007856	GN007856.1	P22682	69.5	443	732	913	2.00e-222	649	CBL_MOUSE	E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)	Mus musculus (Mouse)	bone resorption [GO:0045453]; cell surface receptor signaling pathway [GO:0007166]; cellular response to hypoxia [GO:0071456]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; DNA damage response [GO:0006974]; male gonad development [GO:0008584]; mast cell degranulation [GO:0043303]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein phosphorylation [GO:0006468]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; regulation of Rap protein signal transduction [GO:0032487]; response to activity [GO:0014823]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]; signal transduction [GO:0007165]; ubiquitin-dependent endocytosis [GO:0070086]; ubiquitin-dependent protein catabolic process [GO:0006511]	calcium ion binding [GO:0005509]; ephrin receptor binding [GO:0046875]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; protein tyrosine kinase binding [GO:1990782]; receptor tyrosine kinase binding [GO:0030971]; SH3 domain binding [GO:0017124]; ubiquitin protein ligase activity [GO:0061630]	axon [GO:0030424]; cilium [GO:0005929]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sperm end piece [GO:0097229]	GO:0000209; GO:0001784; GO:0005509; GO:0005794; GO:0005829; GO:0005886; GO:0005925; GO:0005929; GO:0006468; GO:0006511; GO:0006513; GO:0006974; GO:0007165; GO:0007166; GO:0008584; GO:0010332; GO:0014823; GO:0016567; GO:0016600; GO:0017124; GO:0019901; GO:0030424; GO:0030426; GO:0030971; GO:0032487; GO:0033574; GO:0036120; GO:0036312; GO:0042059; GO:0042594; GO:0043066; GO:0043303; GO:0045121; GO:0045453; GO:0045471; GO:0046875; GO:0048260; GO:0048471; GO:0050821; GO:0050860; GO:0050868; GO:0051865; GO:0051897; GO:0061630; GO:0070086; GO:0070534; GO:0071456; GO:0097229; GO:1990090; GO:1990782; GO:2000583
GN007857	GN007857.1	Q08DJ7	45.1	397	397	384	1.08e-122	363	AAR2_BOVIN	Protein AAR2 homolog (AAR2 splicing factor homolog)	Bos taurus (Bovine)	spliceosomal tri-snRNP complex assembly [GO:0000244]			GO:0000244
GN007862	GN007862.1	Q1JPD2	44.6	507	502	558	2.33e-153	451	ABHGA_BOVIN	Phosphatidylserine lipase ABHD16A (EC 3.1.-.-) (Alpha/beta hydrolase domain-containing protein 16A) (Abhydrolase domain-containing protein 16A) (HLA-B-associated transcript 5 homolog) (Monoacylglycerol lipase ABHD16A) (EC 3.1.1.23)	Bos taurus (Bovine)	monoacylglycerol catabolic process [GO:0052651]; phosphatidylserine catabolic process [GO:0006660]	glycerophospholipase activity [GO:0004620]; monoacylglycerol lipase activity [GO:0047372]	membrane [GO:0016020]	GO:0004620; GO:0006660; GO:0016020; GO:0047372; GO:0052651
GN007865	GN007865.1	Q3UFB2	48.6	144	154	460	4.35e-35	129	BCD1_MOUSE	Box C/D snoRNA protein 1 (Zinc finger HIT domain-containing protein 6)	Mus musculus (Mouse)	box C/D snoRNP assembly [GO:0000492]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; protein complex oligomerization [GO:0051259]; snoRNA localization [GO:0048254]	ATPase binding [GO:0051117]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; TFIID-class transcription factor complex binding [GO:0001094]	nucleus [GO:0005634]; pre-snoRNP complex [GO:0070761]	GO:0000463; GO:0000492; GO:0001094; GO:0005634; GO:0019899; GO:0042802; GO:0048254; GO:0051117; GO:0051259; GO:0070761
GN007866	GN007866.1	Q5JUQ0	49.0	243	298	283	1.67e-76	238	FA78A_HUMAN	Protein FAM78A	Homo sapiens (Human)				
GN007869	GN007869.1	P62915	75.6	316	318	316	4.28e-170	477	TF2B_MOUSE	Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (RNA polymerase II alpha initiation factor)	Mus musculus (Mouse)	chromosome organization [GO:0051276]; DNA-templated transcription initiation [GO:0006352]; gene expression [GO:0010467]; meiotic sister chromatid cohesion [GO:0051177]; protein acetylation [GO:0006473]; RNA polymerase II core complex assembly [GO:1990114]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spindle assembly [GO:0051225]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcriptional start site selection at RNA polymerase II promoter [GO:0001174]; viral transcription [GO:0019083]	acetyltransferase activity [GO:0016407]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; nuclear thyroid hormone receptor binding [GO:0046966]; promoter-specific chromatin binding [GO:1990841]; protein-lysine-acetyltransferase activity [GO:0061733]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]; zinc ion binding [GO:0008270]	cell division site [GO:0032153]; chromosome [GO:0005694]; condensed chromosome [GO:0000793]; germinal vesicle [GO:0042585]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription factor TFIID complex [GO:0005669]; transcription preinitiation complex [GO:0097550]	GO:0000776; GO:0000793; GO:0000979; GO:0000993; GO:0001174; GO:0003677; GO:0005634; GO:0005654; GO:0005669; GO:0005694; GO:0006352; GO:0006366; GO:0006367; GO:0006473; GO:0008270; GO:0010467; GO:0016251; GO:0016407; GO:0016604; GO:0017025; GO:0019083; GO:0032153; GO:0032993; GO:0042585; GO:0046966; GO:0051123; GO:0051177; GO:0051225; GO:0051276; GO:0061733; GO:0090575; GO:0097550; GO:0140297; GO:1990114; GO:1990841
GN007870	GN007870.1	O08600	54.3	223	322	294	5.15e-79	245	NUCG_MOUSE	Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-)	Mus musculus (Mouse)	apoptotic DNA fragmentation [GO:0006309]; cellular response to calcium ion [GO:0071277]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; DNA catabolic process [GO:0006308]; DNA damage response [GO:0006974]; in utero embryonic development [GO:0001701]; mitochondrial DNA catabolic process [GO:0032043]; negative regulation of TOR signaling [GO:0032007]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of mitochondrial DNA replication [GO:0090297]; response to antibiotic [GO:0046677]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to tumor necrosis factor [GO:0034612]	DNA endonuclease activity [GO:0004520]; DNA nuclease activity [GO:0004536]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; RNA endonuclease activity [GO:0004521]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]	GO:0000287; GO:0001701; GO:0003676; GO:0004520; GO:0004521; GO:0004536; GO:0005634; GO:0005739; GO:0005743; GO:0006308; GO:0006309; GO:0006974; GO:0009612; GO:0010508; GO:0016787; GO:0032007; GO:0032043; GO:0032355; GO:0034599; GO:0034612; GO:0042803; GO:0043065; GO:0043204; GO:0046677; GO:0048471; GO:0071277; GO:0071333; GO:0071456; GO:0090297; GO:1901300; GO:1902512
GN007875	GN007875.1	Q5ZJF4	65.8	219	220	224	1.82e-103	301	PRDX6_CHICK	Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Glutathione-dependent peroxiredoxin) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx)	Gallus gallus (Chicken)	cell redox homeostasis [GO:0045454]	1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; A2-type glycerophospholipase activity [GO:0004623]; peroxidase activity [GO:0004601]; peroxiredoxin activity [GO:0051920]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0004601; GO:0004623; GO:0005576; GO:0005737; GO:0005764; GO:0005829; GO:0045454; GO:0047184; GO:0051920
GN007876	GN007876.1	Q3TLH4	38.0	395	2566	2846	5.52e-45	184	PRC2C_MOUSE	Protein PRRC2C (BAT2 domain-containing protein 1) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C)	Mus musculus (Mouse)	hematopoietic progenitor cell differentiation [GO:0002244]; stress granule assembly [GO:0034063]		cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]	GO:0002244; GO:0005829; GO:0010494; GO:0034063
GN007878	GN007878.1	Q5T9C2	47.3	184	341	384	1.01e-42	155	EEIG1_HUMAN	Early estrogen-induced gene 1 protein (EEIG1)	Homo sapiens (Human)	positive regulation of osteoclast differentiation [GO:0045672]		cytoplasm [GO:0005737]; membrane raft [GO:0045121]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0045121; GO:0045672
GN007881	GN007881.1	A3KPW9	25.8	1390	1338	1160	1.96e-55	215	BAG6_DANRE	Large proline-rich protein BAG6 (BCL2-associated athanogene 6) (HLA-B-associated transcript 3)	Danio rerio (Zebrafish) (Brachydanio rerio)	brain development [GO:0007420]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; ERAD pathway [GO:0036503]; internal peptidyl-lysine acetylation [GO:0018393]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; lung development [GO:0030324]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of proteolysis [GO:0045861]; proteasomal protein catabolic process [GO:0010498]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of embryonic development [GO:0045995]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; ubiquitin-dependent protein catabolic process [GO:0006511]	misfolded protein binding [GO:0051787]; polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]; ribosome binding [GO:0043022]	BAT3 complex [GO:0071818]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0001822; GO:0005576; GO:0005634; GO:0005829; GO:0006511; GO:0007130; GO:0007283; GO:0007420; GO:0010498; GO:0018393; GO:0030324; GO:0031593; GO:0032435; GO:0036503; GO:0042771; GO:0042981; GO:0043022; GO:0045861; GO:0045995; GO:0050821; GO:0051787; GO:0061857; GO:0070059; GO:0070628; GO:0071816; GO:0071818
GN007883	GN007883.1	Q9IB83	71.8	131	131	237	1.21e-61	191	PSB1B_CARAU	Proteasome subunit beta type-1-B (20S proteasome beta-6 subunit B) (B6-B)	Carassius auratus (Goldfish)	protein catabolic process [GO:0030163]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]	GO:0005634; GO:0005737; GO:0005839; GO:0019774; GO:0030163
GN007884	GN007884.1	Q9DAW6	58.3	511	521	521	1.54e-99	313	PRP4_MOUSE	U4/U6 small nuclear ribonucleoprotein Prp4 (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4)	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]	U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]	Cajal body [GO:0015030]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; spliceosomal snRNP complex [GO:0097525]; U12-type precatalytic spliceosome [GO:0071016]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	GO:0000398; GO:0005634; GO:0005681; GO:0015030; GO:0016607; GO:0017070; GO:0030621; GO:0046540; GO:0071001; GO:0071005; GO:0071011; GO:0071016; GO:0097525
GN007885	GN007885.1	Q6UW60	39.4	497	647	755	1.02e-96	316	PCSK4_HUMAN	Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4)	Homo sapiens (Human)	acrosome reaction [GO:0007340]; binding of sperm to zona pellucida [GO:0007339]; fertilization [GO:0009566]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]; reproductive process [GO:0022414]; sperm capacitation [GO:0048240]	serine-type endopeptidase activity [GO:0004252]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0001669; GO:0002080; GO:0004252; GO:0005802; GO:0007339; GO:0007340; GO:0009566; GO:0016485; GO:0016486; GO:0022414; GO:0048240
GN007891	GN007891.1	Q9Y333	92.6	95	96	95	1.41e-58	177	LSM2_HUMAN	U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)	Homo sapiens (Human)	deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; mRNA catabolic process [GO:0006402]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]	RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; U6 snRNA binding [GO:0017070]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac/U6atac snRNP [GO:0071002]; U4atac/U6atac x U5 tri-snRNP complex [GO:0071009]; U6 snRNP [GO:0005688]; U6atac snRNP [GO:0005691]	GO:0000244; GO:0000290; GO:0000387; GO:0000398; GO:0000932; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005688; GO:0005691; GO:0005737; GO:0005829; GO:0006402; GO:0017070; GO:0031267; GO:0046540; GO:0071001; GO:0071002; GO:0071005; GO:0071009; GO:0071011; GO:0071013; GO:0120115; GO:1990726
GN007892	GN007892.1	Q05B52	55.2	223	249	265	2.55e-89	268	COQ4_BOVIN	Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase) (EC 4.1.1.130) (Coenzyme Q biosynthesis protein 4 homolog)	Bos taurus (Bovine)	ubiquinone biosynthetic process [GO:0006744]	4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity [GO:0120539]; zinc ion binding [GO:0008270]	extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrion [GO:0005739]	GO:0005739; GO:0006744; GO:0008270; GO:0031314; GO:0120539
GN007893	GN007893.1	Q8BRH4	46.9	64	973	4903	3.12e-10	68.6	KMT2C_MOUSE	Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog)	Mus musculus (Mouse)	eyelid development in camera-type eye [GO:0061029]; multicellular organism growth [GO:0035264]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; single fertilization [GO:0007338]	histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; histone methyltransferase activity [GO:0042054]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005654; GO:0005829; GO:0007338; GO:0010468; GO:0035097; GO:0035264; GO:0042054; GO:0042800; GO:0044666; GO:0045944; GO:0048146; GO:0061029; GO:0140945
GN007895	GN007895.1	Q641Y2	73.7	433	468	463	3.11e-242	672	NDUS2_RAT	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 7.1.1.2) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit)	Rattus norvegicus (Rat)	cellular response to oxygen levels [GO:0071453]; gliogenesis [GO:0042063]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; neural precursor cell proliferation [GO:0061351]; neurogenesis [GO:0022008]	NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; oxygen sensor activity [GO:0019826]; quinone binding [GO:0048038]; ubiquitin protein ligase binding [GO:0031625]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271]	GO:0005739; GO:0005743; GO:0006120; GO:0008137; GO:0019826; GO:0022008; GO:0031625; GO:0032981; GO:0042063; GO:0042775; GO:0045271; GO:0048038; GO:0051287; GO:0061351; GO:0071453
GN007898	GN007898.1	J3S6Y1	35.1	661	661	670	4.17e-96	313	TSEAR_MOUSE	Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)	Mus musculus (Mouse)	hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]		cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]	GO:0005576; GO:0007165; GO:0007219; GO:0007605; GO:0008593; GO:0009986; GO:0022405; GO:0032420; GO:0034505; GO:0060170
GN007899	GN007899.1	A2AX52	22.0	838	2327	2309	8.72e-37	157	CO6A4_MOUSE	Collagen alpha-4(VI) chain	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]	collagen binding [GO:0005518]	collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991]	GO:0005518; GO:0005576; GO:0005589; GO:0030198; GO:0031012; GO:0032991
GN007900	GN007900.1	P98158	49.1	2198	2225	4660	1.59e-202	687	LRP2_RAT	Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)	Rattus norvegicus (Rat)	amyloid-beta clearance [GO:0097242]; animal organ regeneration [GO:0031100]; aorta development [GO:0035904]; cell population proliferation [GO:0008283]; cellular response to growth factor stimulus [GO:0071363]; chemoattraction of axon [GO:0061642]; coronary artery morphogenesis [GO:0060982]; coronary vasculature development [GO:0060976]; cranial skeletal system development [GO:1904888]; endocytic hemoglobin import into cell [GO:0020028]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; folate import across plasma membrane [GO:1904447]; forebrain development [GO:0030900]; gene expression [GO:0010467]; heart development [GO:0007507]; kidney development [GO:0001822]; male gonad development [GO:0008584]; metal ion transport [GO:0030001]; metanephric proximal tubule development [GO:0072237]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; neural tube closure [GO:0001843]; neuron projection arborization [GO:0140058]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of endocytosis [GO:0045807]; positive regulation of lipoprotein transport [GO:0140077]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of neurogenesis [GO:0050769]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; protein import [GO:0017038]; protein transport [GO:0015031]; pulmonary artery morphogenesis [GO:0061156]; receptor-mediated endocytosis [GO:0006898]; response to leptin [GO:0044321]; response to retinoic acid [GO:0032526]; response to vitamin D [GO:0033280]; response to X-ray [GO:0010165]; response to xenobiotic stimulus [GO:0009410]; secondary heart field specification [GO:0003139]; sensory perception of sound [GO:0007605]; transcytosis [GO:0045056]; vagina development [GO:0060068]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum development [GO:0003281]; vitamin metabolic process [GO:0006766]	calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; hemoglobin binding [GO:0030492]; hormone binding [GO:0042562]; insulin-like growth factor I binding [GO:0031994]; low-density lipoprotein particle receptor binding [GO:0050750]; nuclear receptor binding [GO:0016922]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; axonal growth cone [GO:0044295]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; signaling receptor complex [GO:0043235]	GO:0001822; GO:0001843; GO:0003139; GO:0003148; GO:0003151; GO:0003223; GO:0003281; GO:0005509; GO:0005576; GO:0005768; GO:0005783; GO:0005794; GO:0005886; GO:0005903; GO:0005905; GO:0006766; GO:0006897; GO:0006898; GO:0007507; GO:0007605; GO:0008283; GO:0008584; GO:0009410; GO:0009897; GO:0009986; GO:0010165; GO:0010467; GO:0015031; GO:0016020; GO:0016197; GO:0016324; GO:0016922; GO:0017038; GO:0020028; GO:0030001; GO:0030139; GO:0030165; GO:0030424; GO:0030425; GO:0030492; GO:0030514; GO:0030900; GO:0031100; GO:0031526; GO:0031904; GO:0031994; GO:0032526; GO:0032991; GO:0033280; GO:0035904; GO:0038024; GO:0042562; GO:0043066; GO:0043235; GO:0043491; GO:0044295; GO:0044321; GO:0044877; GO:0045056; GO:0045177; GO:0045807; GO:0050750; GO:0050769; GO:0051087; GO:0060068; GO:0060976; GO:0060982; GO:0061156; GO:0061642; GO:0070447; GO:0070495; GO:0071363; GO:0072237; GO:0097242; GO:0140058; GO:0140077; GO:1904447; GO:1904888; GO:1905167
GN007901	GN007901.1	A2ARV4	36.5	944	1167	4660	3.84e-168	556	LRP2_MOUSE	Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)	Mus musculus (Mouse)	amyloid-beta clearance [GO:0097242]; aorta development [GO:0035904]; cell population proliferation [GO:0008283]; cellular response to growth factor stimulus [GO:0071363]; chemoattraction of axon [GO:0061642]; coronary artery morphogenesis [GO:0060982]; coronary vasculature development [GO:0060976]; cranial skeletal system development [GO:1904888]; endocytic hemoglobin import into cell [GO:0020028]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; folate import across plasma membrane [GO:1904447]; forebrain development [GO:0030900]; gene expression [GO:0010467]; heart development [GO:0007507]; kidney development [GO:0001822]; male gonad development [GO:0008584]; metal ion transport [GO:0030001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; neural tube closure [GO:0001843]; neuron projection arborization [GO:0140058]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of endocytosis [GO:0045807]; positive regulation of lipoprotein transport [GO:0140077]; positive regulation of neurogenesis [GO:0050769]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; protein import [GO:0017038]; protein transport [GO:0015031]; pulmonary artery morphogenesis [GO:0061156]; receptor-mediated endocytosis [GO:0006898]; response to leptin [GO:0044321]; response to X-ray [GO:0010165]; secondary heart field specification [GO:0003139]; sensory perception of sound [GO:0007605]; smoothened signaling pathway [GO:0007224]; transcytosis [GO:0045056]; vagina development [GO:0060068]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum development [GO:0003281]; vitamin metabolic process [GO:0006766]	calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; hemoglobin binding [GO:0030492]; hormone binding [GO:0042562]; insulin-like growth factor I binding [GO:0031994]; low-density lipoprotein particle receptor binding [GO:0050750]; nuclear receptor binding [GO:0016922]; PDZ domain binding [GO:0030165]; protein transporter activity [GO:0140318]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; axon [GO:0030424]; axonal growth cone [GO:0044295]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; signaling receptor complex [GO:0043235]	GO:0001822; GO:0001843; GO:0003139; GO:0003148; GO:0003151; GO:0003223; GO:0003281; GO:0005509; GO:0005576; GO:0005768; GO:0005783; GO:0005794; GO:0005886; GO:0005903; GO:0005905; GO:0006766; GO:0006897; GO:0006898; GO:0007224; GO:0007507; GO:0007605; GO:0008283; GO:0008584; GO:0009897; GO:0009986; GO:0010165; GO:0010467; GO:0015031; GO:0016020; GO:0016197; GO:0016324; GO:0016922; GO:0017038; GO:0020028; GO:0030001; GO:0030139; GO:0030165; GO:0030424; GO:0030425; GO:0030492; GO:0030514; GO:0030900; GO:0031526; GO:0031904; GO:0031994; GO:0032991; GO:0035904; GO:0038024; GO:0042562; GO:0043066; GO:0043235; GO:0043491; GO:0044295; GO:0044321; GO:0044877; GO:0045056; GO:0045177; GO:0045807; GO:0050750; GO:0050769; GO:0051087; GO:0060068; GO:0060976; GO:0060982; GO:0061156; GO:0061642; GO:0070447; GO:0071363; GO:0097242; GO:0140058; GO:0140077; GO:0140318; GO:1904447; GO:1904888
GN007902	GN007902.1	P98164	38.6	428	509	4655	1.37e-90	306	LRP2_HUMAN	Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)	Homo sapiens (Human)	amyloid-beta clearance [GO:0097242]; cellular response to growth factor stimulus [GO:0071363]; cobalamin transport [GO:0015889]; coronary artery morphogenesis [GO:0060982]; endocytosis [GO:0006897]; folate import across plasma membrane [GO:1904447]; lipid metabolic process [GO:0006629]; male gonad development [GO:0008584]; metal ion transport [GO:0030001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; neural tube closure [GO:0001843]; neuron projection arborization [GO:0140058]; outflow tract septum morphogenesis [GO:0003148]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of neurogenesis [GO:0050769]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; protein transport [GO:0015031]; pulmonary artery morphogenesis [GO:0061156]; receptor-mediated endocytosis [GO:0006898]; response to leptin [GO:0044321]; retinoid metabolic process [GO:0001523]; secondary heart field specification [GO:0003139]; sensory perception of sound [GO:0007605]; transcytosis [GO:0045056]; transport across blood-brain barrier [GO:0150104]; vagina development [GO:0060068]; ventricular compact myocardium morphogenesis [GO:0003223]; vitamin D metabolic process [GO:0042359]	calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; hormone binding [GO:0042562]; insulin-like growth factor I binding [GO:0031994]; low-density lipoprotein particle receptor activity [GO:0005041]; protein-folding chaperone binding [GO:0051087]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; brush border membrane [GO:0031526]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001523; GO:0001843; GO:0003139; GO:0003148; GO:0003223; GO:0005041; GO:0005509; GO:0005764; GO:0005765; GO:0005783; GO:0005794; GO:0005886; GO:0005905; GO:0006629; GO:0006897; GO:0006898; GO:0007605; GO:0008584; GO:0009897; GO:0015031; GO:0015889; GO:0016324; GO:0030001; GO:0030424; GO:0030425; GO:0030514; GO:0030669; GO:0031526; GO:0031904; GO:0031994; GO:0038024; GO:0042359; GO:0042562; GO:0043066; GO:0043235; GO:0043491; GO:0044321; GO:0045056; GO:0050769; GO:0051087; GO:0060068; GO:0060982; GO:0061156; GO:0070062; GO:0070447; GO:0071363; GO:0097242; GO:0140058; GO:0150104; GO:1904447; GO:1905167
GN007903	GN007903.1	Q04833	32.0	178	183	4753	2.24e-27	111	LRP_CAEEL	Low-density lipoprotein receptor-related protein (LRP)	Caenorhabditis elegans	ecdysis, collagen and cuticulin-based cuticle [GO:0042395]; nematode larval development [GO:0002119]; positive regulation of locomotion [GO:0040017]; positive regulation of multicellular organism growth [GO:0040018]; regulation of cell migration [GO:0030334]; sterol transport [GO:0015918]	calcium ion binding [GO:0005509]; lipoprotein particle receptor activity [GO:0030228]	apical plasma membrane [GO:0016324]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886]	GO:0002119; GO:0005509; GO:0005886; GO:0015918; GO:0016324; GO:0030139; GO:0030228; GO:0030334; GO:0040017; GO:0040018; GO:0042395
GN007904	GN007904.1	Q9NWM8	47.4	194	210	211	6.95e-46	154	FKB14_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (22 kDa FK506-binding protein) (22 kDa FKBP) (FKBP-22) (FK506-binding protein 14) (FKBP-14) (Rotamase)	Homo sapiens (Human)		calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]	GO:0003755; GO:0005509; GO:0005788
GN007905	GN007905.1	P59024	36.0	172	225	211	7.91e-34	123	FKB14_MOUSE	Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (FK506-binding protein 14) (FKBP-14) (Rotamase)	Mus musculus (Mouse)		calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]	GO:0003755; GO:0005509; GO:0005788
GN007906	GN007906.1	P59024	32.5	191	228	211	7.18e-24	97.8	FKB14_MOUSE	Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (FK506-binding protein 14) (FKBP-14) (Rotamase)	Mus musculus (Mouse)		calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]	GO:0003755; GO:0005509; GO:0005788
GN007908	GN007908.1	P59024	35.5	172	225	211	6.20e-33	121	FKB14_MOUSE	Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (FK506-binding protein 14) (FKBP-14) (Rotamase)	Mus musculus (Mouse)		calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]	GO:0003755; GO:0005509; GO:0005788
GN007909	GN007909.1	P59024	32.5	191	228	211	5.12e-24	98.2	FKB14_MOUSE	Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (FK506-binding protein 14) (FKBP-14) (Rotamase)	Mus musculus (Mouse)		calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]	GO:0003755; GO:0005509; GO:0005788
GN007911	GN007911.1	Q9NWM8	28.2	195	213	211	1.32e-16	78.2	FKB14_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (22 kDa FK506-binding protein) (22 kDa FKBP) (FKBP-22) (FK506-binding protein 14) (FKBP-14) (Rotamase)	Homo sapiens (Human)		calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]	GO:0003755; GO:0005509; GO:0005788
GN007912	GN007912.1	P59024	34.8	210	220	211	5.59e-18	82.0	FKB14_MOUSE	Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (FK506-binding protein 14) (FKBP-14) (Rotamase)	Mus musculus (Mouse)		calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]	GO:0003755; GO:0005509; GO:0005788
GN007914	GN007914.1	O08688	44.8	649	647	640	2.38e-191	557	CAN5_MOUSE	Calpain-5 (EC 3.4.22.-) (New calpain 3) (nCL-3)	Mus musculus (Mouse)	proteolysis [GO:0006508]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; synapse [GO:0045202]	GO:0004198; GO:0005737; GO:0006508; GO:0009986; GO:0045202
GN007915	GN007915.1	O42131	66.0	1316	1682	1627	0.0	1726	TOP2B_CHICK	DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)	Gallus gallus (Chicken)	B cell differentiation [GO:0030183]; DNA topological change [GO:0006265]; resolution of meiotic recombination intermediates [GO:0000712]; sister chromatid segregation [GO:0000819]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA topoisomerase activity [GO:0003916]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0000712; GO:0000819; GO:0003677; GO:0003916; GO:0003918; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0006265; GO:0030183; GO:1990904
GN007916	GN007916.1	P60604	83.0	165	165	165	4.23e-102	293	UB2G2_HUMAN	Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)	Homo sapiens (Human)	cellular response to interferon-beta [GO:0035458]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	identical protein binding [GO:0042802]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]	GO:0000209; GO:0004842; GO:0005783; GO:0005811; GO:0005829; GO:0006511; GO:0035458; GO:0036503; GO:0042802; GO:0061631; GO:0070936; GO:1904153
GN007917	GN007917.1	Q5R8X7	56.8	586	929	966	2.00e-199	599	M3K13_PONAB	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	JNK cascade [GO:0007254]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; stress-activated MAPK cascade [GO:0051403]	ATP binding [GO:0005524]; IkappaB kinase complex binding [GO:0106137]; MAP kinase kinase kinase activity [GO:0004709]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0004674; GO:0004709; GO:0005524; GO:0005737; GO:0007254; GO:0016020; GO:0042803; GO:0043123; GO:0051403; GO:0106137; GO:0106310
GN007918	GN007918.1	A0LMC1	38.5	273	281	277	1.83e-61	198	PHNX_SYNFM	Phosphonoacetaldehyde hydrolase (Phosphonatase) (EC 3.11.1.1) (Phosphonoacetaldehyde phosphonohydrolase)	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	DNA repair [GO:0006281]; organic phosphonate catabolic process [GO:0019700]	phosphoglycolate phosphatase activity [GO:0008967]; phosphonoacetaldehyde hydrolase activity [GO:0050194]	cytosol [GO:0005829]	GO:0005829; GO:0006281; GO:0008967; GO:0019700; GO:0050194
GN007919	GN007919.1	Q63850	60.0	115	363	526	8.21e-31	125	NUP62_MOUSE	Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62)	Mus musculus (Mouse)	cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; cellular senescence [GO:0090398]; centriole assembly [GO:0098534]; centrosome cycle [GO:0007098]; mitotic centrosome separation [GO:0007100]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of programmed cell death [GO:0043069]; negative regulation of Ras protein signal transduction [GO:0046580]; nucleocytoplasmic transport [GO:0006913]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of centriole replication [GO:0046601]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mitotic cytokinetic process [GO:1903438]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of protein localization to centrosome [GO:1904781]; protein import into nucleus [GO:0006606]; regulation of mitotic spindle organization [GO:0060236]; regulation of protein import into nucleus [GO:0042306]; RNA export from nucleus [GO:0006405]	Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; kinesin binding [GO:0019894]; nuclear thyroid hormone receptor binding [GO:0046966]; phospholipid binding [GO:0005543]; protein-containing complex binding [GO:0044877]; PTB domain binding [GO:0051425]; SH2 domain binding [GO:0042169]; signaling receptor complex adaptor activity [GO:0030159]; structural constituent of nuclear pore [GO:0017056]; ubiquitin binding [GO:0043130]	annulate lamellae [GO:0005642]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore central transport channel [GO:0044613]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; spindle pole [GO:0000922]	GO:0000922; GO:0005543; GO:0005635; GO:0005642; GO:0005643; GO:0005654; GO:0005737; GO:0005813; GO:0006405; GO:0006606; GO:0006913; GO:0007080; GO:0007098; GO:0007100; GO:0007166; GO:0008285; GO:0016477; GO:0017056; GO:0019894; GO:0030159; GO:0030544; GO:0031965; GO:0032991; GO:0042059; GO:0042169; GO:0042306; GO:0043066; GO:0043069; GO:0043123; GO:0043130; GO:0043407; GO:0044613; GO:0044877; GO:0045840; GO:0045893; GO:0046580; GO:0046601; GO:0046966; GO:0051425; GO:0051879; GO:0060236; GO:0072686; GO:0090398; GO:0090543; GO:0098534; GO:1903438; GO:1904781; GO:1990904
GN007924	GN007924.1	G5EBQ8	36.4	1379	1717	1668	1.12e-219	697	CHS2_CAEEL	Chitin synthase chs-2 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase chs-2)	Caenorhabditis elegans	chitin biosynthetic process [GO:0006031]; positive regulation of nematode larval development [GO:0061063]	chitin synthase activity [GO:0004100]	plasma membrane [GO:0005886]	GO:0004100; GO:0005886; GO:0006031; GO:0061063
GN007925	GN007925.1	Q5R5L3	43.3	753	791	793	8.46e-221	643	DJC10_PONAB	Endoplasmic reticulum disulfide reductase DNAJC10 (EC 1.8.4.2) (DnaJ homolog subfamily C member 10)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	ERAD pathway [GO:0036503]; IRE1-mediated unfolded protein response [GO:0036498]; protein folding in endoplasmic reticulum [GO:0034975]	ATPase binding [GO:0051117]; misfolded protein binding [GO:0051787]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein-disulfide reductase (glutathione) activity [GO:0019153]; protein-disulfide reductase activity [GO:0015035]; protein-folding chaperone binding [GO:0051087]	endoplasmic reticulum lumen [GO:0005788]	GO:0005788; GO:0015035; GO:0016671; GO:0019153; GO:0034975; GO:0036498; GO:0036503; GO:0051087; GO:0051117; GO:0051787
GN007926	GN007926.1	Q9QZB9	78.4	176	189	182	3.14e-70	214	DCTN5_MOUSE	Dynactin subunit 5 (Dynactin subunit p25)	Mus musculus (Mouse)	aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; ventricular septum development [GO:0003281]		centrosome [GO:0005813]; dynactin complex [GO:0005869]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]	GO:0003281; GO:0005654; GO:0005813; GO:0005869; GO:0031965; GO:0035904; GO:0060976
GN007929	GN007929.1	G5EBQ8	39.8	1000	1162	1668	2.74e-213	664	CHS2_CAEEL	Chitin synthase chs-2 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase chs-2)	Caenorhabditis elegans	chitin biosynthetic process [GO:0006031]; positive regulation of nematode larval development [GO:0061063]	chitin synthase activity [GO:0004100]	plasma membrane [GO:0005886]	GO:0004100; GO:0005886; GO:0006031; GO:0061063
GN007931	GN007931.1	Q6F6U3	39.5	223	284	214	2.85e-48	162	PNCA_ACIAD	Nicotinamidase (EC 3.5.1.19) (Nicotinamide deamidase) (NAMase)	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)		nicotinamidase activity [GO:0008936]		GO:0008936
GN007932	GN007932.1	P50170	41.3	317	323	317	6.43e-72	228	RDH16_RAT	Retinol dehydrogenase 16 (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (29 kDa protein) (Retinol dehydrogenase 2) (Retinol dehydrogenase type 1) (Retinol dehydrogenase type II) (RODH II)	Rattus norvegicus (Rat)	androgen biosynthetic process [GO:0006702]; positive regulation of retinoic acid biosynthetic process [GO:1900054]; response to resveratrol [GO:1904638]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]	11-cis-retinol dehydrogenase (NAD+) activity [GO:0106429]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity [GO:0047044]; androsterone dehydrogenase [NAD(P)+] activity [GO:0047023]; identical protein binding [GO:0042802]	endoplasmic reticulum membrane [GO:0005789]; organelle membrane [GO:0031090]	GO:0004745; GO:0005789; GO:0006702; GO:0008202; GO:0031090; GO:0042572; GO:0042573; GO:0042802; GO:0047023; GO:0047044; GO:0106429; GO:1900054; GO:1904638
GN007933	GN007933.1	O54753	48.5	101	122	317	7.48e-24	96.3	H17B6_RAT	17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.239) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase)	Rattus norvegicus (Rat)	androgen metabolic process [GO:0008209]; brexanolone catabolic process [GO:0062175]; estrogen biosynthetic process [GO:0006703]; retinol metabolic process [GO:0042572]	5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity [GO:0047024]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity [GO:0047044]; androsterone dehydrogenase [NAD(P)+] activity [GO:0047023]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; testosterone dehydrogenase (NADP+) activity [GO:0047045]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0004303; GO:0004745; GO:0005783; GO:0005789; GO:0006703; GO:0008209; GO:0042572; GO:0047023; GO:0047024; GO:0047035; GO:0047044; GO:0047045; GO:0062175
GN007935	GN007935.1	Q80VI1	28.5	207	685	734	8.40e-13	75.5	TRI56_MOUSE	E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (Tripartite motif-containing protein 56)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cGAS/STING signaling pathway [GO:0140896]; defense response to virus [GO:0051607]; host-mediated suppression of symbiont invasion [GO:0046597]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; response to type I interferon [GO:0034340]; suppression of viral release by host [GO:0044790]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0005829; GO:0006513; GO:0008270; GO:0032728; GO:0034340; GO:0044790; GO:0045087; GO:0045089; GO:0046597; GO:0051607; GO:0060340; GO:0061630; GO:0070534; GO:0140374; GO:0140896; GO:1901224
GN007937	GN007937.1	Q28HC6	62.6	396	383	396	3.90e-188	529	TGT_XENTR	Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.64) (Guanine insertion enzyme) (tRNA-guanine transglycosylase)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	tRNA wobble guanine modification [GO:0002099]	tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479]	mitochondrial outer membrane [GO:0005741]	GO:0002099; GO:0005741; GO:0008479
GN007939	GN007939.1	Q28GD4	44.2	330	328	375	8.09e-83	258	ELAV2_XENTR	ELAV-like protein 2 (Protein ElrB)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	intracellular mRNA localization [GO:0008298]	protein-RNA adaptor activity [GO:0140517]; RNA binding [GO:0003723]	cell cortex [GO:0005938]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005938; GO:0008298; GO:0140517; GO:1990904
GN007940	GN007940.1	Q28FX0	41.6	317	313	343	1.37e-77	243	ELAV3_XENTR	ELAV-like protein 3 (Protein ElrC)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	intracellular mRNA localization [GO:0008298]	protein-RNA adaptor activity [GO:0140517]; RNA binding [GO:0003723]	cell cortex [GO:0005938]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005938; GO:0008298; GO:0140517; GO:1990904
GN007943	GN007943.1	Q92600	86.0	286	365	299	1.58e-173	487	CNOT9_HUMAN	CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1)	Homo sapiens (Human)	negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; sex differentiation [GO:0007548]	epidermal growth factor receptor binding [GO:0005154]; kinase binding [GO:0019900]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]	GO:0000289; GO:0000932; GO:0003713; GO:0005154; GO:0005634; GO:0005829; GO:0007548; GO:0016020; GO:0017148; GO:0019900; GO:0019904; GO:0030014; GO:0030015; GO:0032991; GO:0033138; GO:0033147; GO:0042803; GO:0045742
GN007945	GN007945.1	Q17QB7	62.8	148	174	203	5.55e-62	193	RAB30_BOVIN	Ras-related protein Rab-30 (EC 3.6.5.2)	Bos taurus (Bovine)	Golgi organization [GO:0007030]; lipid homeostasis [GO:0055088]; Rab protein signal transduction [GO:0032482]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	autolysosome membrane [GO:0120281]; autophagosome membrane [GO:0000421]; cis-Golgi network [GO:0005801]; cis-Golgi network membrane [GO:0033106]; cytoplasm [GO:0005737]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0000421; GO:0003924; GO:0003925; GO:0005525; GO:0005737; GO:0005801; GO:0005802; GO:0007030; GO:0031985; GO:0032482; GO:0033106; GO:0055088; GO:0120281
GN007946	GN007946.1	G3X9Z4	38.8	327	1261	1553	2.61e-50	199	PCF11_MOUSE	Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11)	Mus musculus (Mouse)	mRNA 3'-end processing [GO:0031124]; regulation of mRNA 3'-end processing [GO:0031440]; termination of RNA polymerase II transcription [GO:0006369]	mRNA binding [GO:0003729]; RNA polymerase II complex binding [GO:0000993]	mitochondrion [GO:0005739]; mRNA cleavage factor complex [GO:0005849]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000993; GO:0003729; GO:0005634; GO:0005654; GO:0005739; GO:0005849; GO:0006369; GO:0031124; GO:0031440
GN007947	GN007947.1	O35963	74.9	175	242	229	2.01e-95	281	RB33B_MOUSE	Ras-related protein Rab-33B (EC 3.6.5.2)	Mus musculus (Mouse)	autophagosome assembly [GO:0000045]; intra-Golgi vesicle-mediated transport [GO:0006891]; negative regulation of constitutive secretory pathway [GO:1903434]; protein localization to Golgi apparatus [GO:0034067]; protein localization to phagophore assembly site [GO:0034497]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]; regulation of Golgi organization [GO:1903358]; regulation of retrograde vesicle-mediated transport, Golgi to ER [GO:2000156]; skeletal system morphogenesis [GO:0048705]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; phagophore assembly site membrane [GO:0034045]; presynapse [GO:0098793]	GO:0000045; GO:0000139; GO:0003924; GO:0003925; GO:0005525; GO:0005794; GO:0005796; GO:0006891; GO:0017157; GO:0032482; GO:0034045; GO:0034067; GO:0034497; GO:0048705; GO:0098793; GO:1903358; GO:1903434; GO:2000156
GN007948	GN007948.1	A0A0R4IAX5	60.6	536	594	549	7.93e-232	654	URGL_DANRE	Ureidoglycolate lyase (EC 4.3.2.3) (Malate synthase-like) (MLSL) (MSL)	Danio rerio (Zebrafish) (Brachydanio rerio)	glyoxylate cycle [GO:0006097]; urate catabolic process [GO:0019628]	ureidoglycolate lyase activity [GO:0050385]	cytoplasm [GO:0005737]; peroxisomal matrix [GO:0005782]	GO:0005737; GO:0005782; GO:0006097; GO:0019628; GO:0050385
GN007949	GN007949.1	Q04861	32.7	153	454	983	5.19e-09	62.4	NFKB1_CHICK	Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]	Gallus gallus (Chicken)	canonical NF-kappaB signal transduction [GO:0007249]; positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; NF-kappaB binding [GO:0051059]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; NF-kappaB p50/p65 complex [GO:0035525]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0005737; GO:0007249; GO:0035525; GO:0045944; GO:0051059
GN007950	GN007950.1	Q9NPJ8	45.2	93	89	142	1.98e-26	97.4	NXT2_HUMAN	NTF2-related export protein 2 (Protein p15-2)	Homo sapiens (Human)	poly(A)+ mRNA export from nucleus [GO:0016973]		cytosol [GO:0005829]; nuclear pore central transport channel [GO:0044613]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	GO:0005654; GO:0005829; GO:0016973; GO:0042272; GO:0044613; GO:0048471
GN007951	GN007951.1	A1A4M4	55.1	265	272	273	1.76e-97	290	TATD3_BOVIN	Putative deoxyribonuclease TATDN3 (EC 3.1.21.-)	Bos taurus (Bovine)		DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]	nucleus [GO:0005634]	GO:0003906; GO:0005634; GO:0008310
GN007952	GN007952.1	Q99ME3	26.5	155	1020	962	6.56e-09	63.9	SNCAP_MOUSE	Synphilin-1 (Alpha-synuclein-interacting protein)	Mus musculus (Mouse)	dopamine metabolic process [GO:0042417]; regulation of inclusion body assembly [GO:0090083]; regulation of neurotransmitter secretion [GO:0046928]	identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0031625; GO:0036464; GO:0042417; GO:0042802; GO:0046928; GO:0090083
GN007959	GN007959.1	Q96G03	55.5	503	501	612	1.35e-196	563	PGM2_HUMAN	Phosphopentomutase (EC 5.4.2.7) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphoglucomutase-2) (EC 5.4.2.2)	Homo sapiens (Human)	glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; purine ribonucleoside salvage [GO:0006166]	magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]; phosphopentomutase activity [GO:0008973]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]	GO:0000287; GO:0004614; GO:0005576; GO:0005829; GO:0005978; GO:0005980; GO:0006166; GO:0008973; GO:0034774; GO:0070062; GO:1904813
GN007960	GN007960.1	Q96SL1	39.2	439	488	478	4.40e-97	304	DIRC2_HUMAN	Solute carrier family 49 member 4 (Disrupted in renal cancer protein 2) (Disrupted in renal carcinoma protein 2)	Homo sapiens (Human)	pyridoxine transport [GO:0031923]	transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]; membrane [GO:0016020]	GO:0005765; GO:0016020; GO:0022857; GO:0031923
GN007961	GN007961.1	Q60613	28.5	242	522	410	2.35e-12	72.4	AA2AR_MOUSE	Adenosine receptor A2a	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; astrocyte activation [GO:0048143]; eating behavior [GO:0042755]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; G protein-coupled receptor signaling pathway [GO:0007186]; inhibition of non-skeletal tissue mineralization [GO:0140928]; inhibitory postsynaptic potential [GO:0060080]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of vascular permeability [GO:0043116]; neuron projection morphogenesis [GO:0048812]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein secretion [GO:0050714]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of urine volume [GO:0035810]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of calcium ion transport [GO:0051924]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of norepinephrine secretion [GO:0014061]; response to alkaloid [GO:0043279]; response to amphetamine [GO:0001975]; response to caffeine [GO:0031000]; response to purine-containing compound [GO:0014074]; response to xenobiotic stimulus [GO:0009410]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission, dopaminergic [GO:0001963]; synaptic transmission, glutamatergic [GO:0035249]; vasodilation [GO:0042311]	alpha-actinin binding [GO:0051393]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; G protein-coupled adenosine receptor activity [GO:0001609]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein-containing complex binding [GO:0044877]; type 5 metabotropic glutamate receptor binding [GO:0031802]	asymmetric synapse [GO:0032279]; axolemma [GO:0030673]; axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; intermediate filament [GO:0005882]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]	GO:0001609; GO:0001963; GO:0001973; GO:0001975; GO:0005516; GO:0005882; GO:0005886; GO:0006355; GO:0006469; GO:0007186; GO:0007189; GO:0007200; GO:0007271; GO:0007626; GO:0008285; GO:0008289; GO:0009410; GO:0014049; GO:0014057; GO:0014061; GO:0014074; GO:0016020; GO:0019899; GO:0030424; GO:0030425; GO:0030673; GO:0031000; GO:0031802; GO:0032230; GO:0032279; GO:0035249; GO:0035810; GO:0042311; GO:0042734; GO:0042755; GO:0042802; GO:0043025; GO:0043116; GO:0043279; GO:0043524; GO:0044877; GO:0045211; GO:0045938; GO:0046636; GO:0048143; GO:0048786; GO:0048812; GO:0050714; GO:0050728; GO:0051393; GO:0051881; GO:0051899; GO:0051924; GO:0051968; GO:0060079; GO:0060080; GO:0060134; GO:0070374; GO:0098978; GO:0099171; GO:0140928; GO:1900273; GO:2001235
GN007962	GN007962.1	Q299G2	57.0	1059	1236	1291	0.0	1208	CYFIP_DROPS	Cytoplasmic FMR1-interacting protein (Specifically Rac1-associated protein 1)	Drosophila pseudoobscura pseudoobscura (Fruit fly)	axon guidance [GO:0007411]; cell projection assembly [GO:0030031]; chaeta development [GO:0022416]; cortical actin cytoskeleton organization [GO:0030866]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of synapse organization [GO:0050807]	small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; SCAR complex [GO:0031209]	GO:0005737; GO:0007411; GO:0008360; GO:0022416; GO:0030031; GO:0030833; GO:0030866; GO:0031209; GO:0031267; GO:0050807
GN007964	GN007964.1	Q09225	42.4	92	138	822	1.05e-20	90.1	NRF6_CAEEL	Nose resistant to fluoxetine protein 6 (Protein nrf-6)	Caenorhabditis elegans		acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]	membrane [GO:0016020]	GO:0016020; GO:0016747
GN007968	GN007968.1	Q4V7B8	39.8	93	108	350	3.54e-19	83.6	RNF44_RAT	RING finger protein 44	Rattus norvegicus (Rat)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]		GO:0016567; GO:0061630
GN007969	GN007969.1	Q91VE0	50.2	613	664	643	1.64e-220	632	S27A4_MOUSE	Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 4) (Very long-chain acyl-CoA synthetase 4) (ACSVL4) (EC 6.2.1.-)	Mus musculus (Mouse)	fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; glucose import in response to insulin stimulus [GO:0044381]; lipid transport across blood-brain barrier [GO:1990379]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity [GO:0062003]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of apoptotic process [GO:0043065]; response to nutrient [GO:0007584]; skin development [GO:0043588]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038]	arachidonate-CoA ligase activity [GO:0047676]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oleoyl-CoA ligase activity [GO:0090434]; palmitoyl-CoA ligase activity [GO:0090433]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	brush border membrane [GO:0031526]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	GO:0000038; GO:0001579; GO:0001676; GO:0004467; GO:0005324; GO:0005783; GO:0005789; GO:0005886; GO:0005902; GO:0006631; GO:0007584; GO:0015908; GO:0015909; GO:0031526; GO:0031957; GO:0042760; GO:0043065; GO:0043588; GO:0044381; GO:0044539; GO:0046627; GO:0047676; GO:0062003; GO:0090433; GO:0090434; GO:1990379
GN007970	GN007970.1	Q9XWN7	35.6	329	318	338	3.12e-46	162	NSH1_CAEEL	Nucleoside hydrolase (EC 3.2.2.-) (EC 3.2.2.1) (EC 3.2.2.2) (EC 3.2.2.3) (EC 3.2.2.7) (EC 3.2.2.8)	Caenorhabditis elegans	purine nucleoside catabolic process [GO:0006152]	adenosine nucleosidase activity [GO:0047622]; calcium ion binding [GO:0005509]; inosine nucleosidase activity [GO:0047724]; purine nucleosidase activity [GO:0008477]; ribosylpyrimidine nucleosidase activity [GO:0050263]; uridine nucleosidase activity [GO:0045437]; xanthosine nucleotidase activity [GO:0072585]		GO:0005509; GO:0006152; GO:0008477; GO:0045437; GO:0047622; GO:0047724; GO:0050263; GO:0072585
GN007973	GN007973.1	Q5WR10	86.6	425	426	428	4.36e-269	737	DX39B_CANLF	Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (DEAD box protein UAP56)	Canis lupus familiaris (Dog) (Canis familiaris)	mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]	GO:0000398; GO:0003676; GO:0003724; GO:0005524; GO:0005737; GO:0006406; GO:0016607; GO:0016887
GN007974	GN007974.1	Q8VDW0	64.8	355	408	427	3.64e-169	483	DX39A_MOUSE	ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39)	Mus musculus (Mouse)	cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of innate immune response [GO:0045824]; negative regulation of RNA export from nucleus [GO:0046832]; toll-like receptor signaling pathway [GO:0002224]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0000398; GO:0002224; GO:0002753; GO:0003723; GO:0003724; GO:0005524; GO:0005634; GO:0005737; GO:0006406; GO:0016607; GO:0016887; GO:0042802; GO:0045824; GO:0046832
GN007975	GN007975.1	Q27268	51.5	66	70	424	3.12e-15	71.2	DX39B_DROME	ATP-dependent RNA helicase WM6 (DEAD box protein UAP56) (Dmrnahel) (EC 3.6.4.13) (HEL/UAP56)	Drosophila melanogaster (Fruit fly)	chromatin remodeling [GO:0006338]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; piRNA processing [GO:0034587]; positive regulation of piRNA transcription [GO:0140543]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; secondary piRNA processing [GO:0140965]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; piRNA binding [GO:0034584]; RNA helicase activity [GO:0003724]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; P granule [GO:0043186]; spliceosomal complex [GO:0005681]; transcription export complex [GO:0000346]	GO:0000346; GO:0000381; GO:0000398; GO:0003724; GO:0005524; GO:0005634; GO:0005681; GO:0006338; GO:0006406; GO:0016607; GO:0016887; GO:0034584; GO:0034587; GO:0043186; GO:0140543; GO:0140965
GN007978	GN007978.1	Q9D818	27.6	471	485	391	2.79e-29	122	SAPC2_MOUSE	Suppressor APC domain-containing protein 2 (Protein Ang)	Mus musculus (Mouse)	establishment of mitotic spindle orientation [GO:0000132]; negative regulation of protein localization to cell cortex [GO:1904777]; positive regulation of cell population proliferation [GO:0008284]; regulation of establishment of planar polarity [GO:0090175]; symmetric cell division [GO:0098725]		apical cortex [GO:0045179]; apical junction complex [GO:0043296]; apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000132; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0005923; GO:0008284; GO:0016324; GO:0043296; GO:0045179; GO:0090175; GO:0098725; GO:1904777
GN007980	GN007980.1	F4KD71	30.0	404	710	704	5.70e-42	166	DUR3_ARATH	Urea-proton symporter DUR3 (AtDUR3) (High-affinity urea active transporter DUR3)	Arabidopsis thaliana (Mouse-ear cress)	cellular response to nitrogen starvation [GO:0006995]; urea transmembrane transport [GO:0071918]	urea binding [GO:0033219]; urea transmembrane transporter activity [GO:0015204]	chloroplast [GO:0009507]; plasma membrane [GO:0005886]	GO:0005886; GO:0006995; GO:0009507; GO:0015204; GO:0033219; GO:0071918
GN007981	GN007981.1	Q6P0F0	63.0	81	110	110	8.35e-30	105	EMC6_DANRE	ER membrane protein complex subunit 6 (Transmembrane protein 93)	Danio rerio (Zebrafish) (Brachydanio rerio)	autophagosome assembly [GO:0000045]; protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]		EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0000045; GO:0005789; GO:0016020; GO:0045050; GO:0071816; GO:0072546
GN007982	GN007982.1	Q96PQ7	72.5	567	605	755	6.58e-164	489	KLHL5_HUMAN	Kelch-like protein 5	Homo sapiens (Human)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]	GO:0005737; GO:0005829; GO:0015630; GO:0031463; GO:0043161; GO:1990756
GN007983	GN007983.1	Q86TZ1	31.9	505	2193	520	1.41e-71	253	TTC6_HUMAN	Tetratricopeptide repeat protein 6 (TPR repeat protein 6)	Homo sapiens (Human)				
GN007984	GN007984.1	Q68EV6	45.2	219	288	253	1.15e-52	175	RM28_XENLA	Large ribosomal subunit protein bL28m (39S ribosomal protein L28, mitochondrial) (L28mt) (MRP-L28)	Xenopus laevis (African clawed frog)		structural constituent of ribosome [GO:0003735]	mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005762
GN007988	GN007988.1	Q99453	50.3	183	292	314	4.40e-37	137	PHX2B_HUMAN	Paired mesoderm homeobox protein 2B (Neuroblastoma Phox) (NBPhox) (PHOX2B homeodomain protein) (Paired-like homeobox 2B)	Homo sapiens (Human)	autonomic nervous system development [GO:0048483]; brainstem development [GO:0003360]; cell differentiation in hindbrain [GO:0021533]; cellular response to BMP stimulus [GO:0071773]; dopaminergic neuron differentiation [GO:0071542]; efferent axon development in a lateral line nerve [GO:0048894]; enteric nervous system development [GO:0048484]; glial cell differentiation [GO:0010001]; hindbrain tangential cell migration [GO:0021934]; inner ear development [GO:0048839]; medullary reticular formation development [GO:0021723]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron development [GO:0048666]; neuron migration [GO:0001764]; noradrenergic neuron development [GO:0003358]; noradrenergic neuron differentiation [GO:0003357]; parasympathetic nervous system development [GO:0048486]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory system development [GO:0060541]; retrotrapezoid nucleus neuron differentiation [GO:0061452]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0001764; GO:0002087; GO:0003357; GO:0003358; GO:0003360; GO:0005634; GO:0005654; GO:0006357; GO:0010001; GO:0010468; GO:0010971; GO:0021533; GO:0021723; GO:0021934; GO:0045944; GO:0048483; GO:0048484; GO:0048485; GO:0048486; GO:0048666; GO:0048839; GO:0048894; GO:0060541; GO:0061452; GO:0061549; GO:0071542; GO:0071773; GO:0120162; GO:1901166; GO:1990837
GN007989	GN007989.1	P51521	75.9	137	371	1351	1.97e-29	123	OVO_DROME	Transcriptional regulator ovo (Transcriptional repressor shavenbaby) (Transcriptional repressor svb) [Cleaved into: Transcriptional activator shavenbaby (Transcriptional activator svb)]	Drosophila melanogaster (Fruit fly)	adult feeding behavior [GO:0008343]; cuticle pattern formation [GO:0035017]; cuticle pigmentation [GO:0048067]; cytoskeleton organization [GO:0007010]; epidermal cell differentiation [GO:0009913]; germ-line sex determination [GO:0018992]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; non-sensory hair organization [GO:0035316]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357]; transposition [GO:0032196]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription coactivator binding [GO:0001223]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0001223; GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0007010; GO:0008343; GO:0008360; GO:0009913; GO:0016348; GO:0018992; GO:0032196; GO:0035017; GO:0035316; GO:0043565; GO:0045892; GO:0045893; GO:0045944; GO:0048067; GO:1990837
GN007990	GN007990.1	Q9JLM8	26.1	264	731	756	2.89e-12	73.9	DCLK1_MOUSE	Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)	Mus musculus (Mouse)	axon extension [GO:0048675]; axonogenesis [GO:0007409]; brain development [GO:0007420]; central nervous system projection neuron axonogenesis [GO:0021952]; dendrite morphogenesis [GO:0048813]; forebrain development [GO:0030900]; intracellular signal transduction [GO:0035556]; negative regulation of protein localization to nucleus [GO:1900181]; neuron migration [GO:0001764]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of postsynapse assembly [GO:0150052]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	axon [GO:0030424]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]	GO:0001764; GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0006468; GO:0007409; GO:0007420; GO:0014069; GO:0018105; GO:0021952; GO:0030424; GO:0030426; GO:0030900; GO:0035556; GO:0048675; GO:0048813; GO:0098794; GO:0098978; GO:0106310; GO:0150052; GO:1900181
GN007992	GN007992.1	Q62192	29.3	164	540	661	2.05e-09	63.9	CD180_MOUSE	CD180 antigen (Lymphocyte antigen 78) (Ly-78) (Radioprotective 105 kDa protein) (CD antigen CD180)	Mus musculus (Mouse)	B cell proliferation [GO:0042100]; B cell proliferation involved in immune response [GO:0002322]; cellular response to lipopolysaccharide [GO:0071222]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]	lipopolysaccharide immune receptor activity [GO:0001875]; signaling receptor activity [GO:0038023]	mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0001875; GO:0002322; GO:0005654; GO:0005730; GO:0005886; GO:0031666; GO:0038023; GO:0042100; GO:0071222; GO:0072686
GN007993	GN007993.1	P08635	38.9	247	249	263	1.05e-59	192	SAST_RAT	S-acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Medium-chain S-acyl fatty acid synthetase thioester hydrolase) (Oleoyl-ACP hydrolase) (Thioesterase II) (Thioesterase domain-containing protein 1)	Rattus norvegicus (Rat)	lipid biosynthetic process [GO:0008610]; medium-chain fatty acid biosynthetic process [GO:0051792]	fatty acyl-[ACP] hydrolase activity [GO:0016297]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; medium-chain fatty acyl-CoA hydrolase activity [GO:0052815]	cytosol [GO:0005829]	GO:0005829; GO:0008610; GO:0016297; GO:0051792; GO:0052815; GO:0052816
GN007995	GN007995.1	P40938	75.3	316	316	356	4.51e-167	471	RFC3_HUMAN	Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38)	Homo sapiens (Human)	DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication checkpoint signaling [GO:0000076]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-templated DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]	ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]	Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; Elg1 RFC-like complex [GO:0031391]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad17 RFC-like complex [GO:0031389]	GO:0000076; GO:0000731; GO:0003677; GO:0003689; GO:0005634; GO:0005654; GO:0005663; GO:0006260; GO:0006261; GO:0006271; GO:0006281; GO:0008094; GO:0031389; GO:0031390; GO:0031391; GO:1900264
GN007997	GN007997.1	Q9HC56	34.1	745	1098	1237	4.03e-108	369	PCDH9_HUMAN	Protocadherin-9	Homo sapiens (Human)	cell adhesion [GO:0007155]; forebrain development [GO:0030900]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0030900; GO:0050839; GO:0097060; GO:0098978
GN007998	GN007998.1	Q9HC56	31.2	759	988	1237	7.59e-98	338	PCDH9_HUMAN	Protocadherin-9	Homo sapiens (Human)	cell adhesion [GO:0007155]; forebrain development [GO:0030900]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0030900; GO:0050839; GO:0097060; GO:0098978
GN007999	GN007999.1	Q03105	86.9	130	141	154	4.33e-68	205	VATL_TORMA	V-type proton ATPase 16 kDa proteolipid subunit c (V-ATPase 16 kDa proteolipid subunit c) (15 kDa mediatophore protein) (Vacuolar proton pump 16 kDa proteolipid subunit c)	Torpedo marmorata (Marbled electric ray)		proton-transporting ATPase activity, rotational mechanism [GO:0046961]	proton-transporting V-type ATPase, V0 domain [GO:0033179]; vacuolar membrane [GO:0005774]	GO:0005774; GO:0033179; GO:0046961
GN008000	GN008000.1	Q8BU03	54.8	890	931	919	0.0	994	PWP2_MOUSE	Periodic tryptophan protein 2 homolog	Mus musculus (Mouse)	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]		nucleolus [GO:0005730]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]	GO:0000028; GO:0000462; GO:0005730; GO:0032040; GO:0034388; GO:0042274
GN008001	GN008001.1	Q9D5U8	32.2	199	876	673	2.05e-18	94.0	CNBD2_MOUSE	Cyclic nucleotide-binding domain-containing protein 2 (Cyclic nucleotide receptor involved in sperm function)	Mus musculus (Mouse)	spermatogenesis [GO:0007283]	cAMP binding [GO:0030552]	cytosol [GO:0005829]; sperm midpiece [GO:0097225]	GO:0005829; GO:0007283; GO:0030552; GO:0097225
GN008002	GN008002.1	Q0E908	22.1	435	1399	818	2.95e-13	78.6	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN008003	GN008003.1	Q96M20	30.3	231	681	576	6.06e-21	100	CNBD2_HUMAN	Cyclic nucleotide-binding domain-containing protein 2	Homo sapiens (Human)	spermatogenesis [GO:0007283]	cAMP binding [GO:0030552]	cytosol [GO:0005829]; sperm midpiece [GO:0097225]	GO:0005829; GO:0007283; GO:0030552; GO:0097225
GN008005	GN008005.1	Q9Y365	45.1	257	271	291	7.35e-78	240	STA10_HUMAN	START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10)	Homo sapiens (Human)	phosphatidylcholine biosynthetic process [GO:0006656]	lipid carrier activity [GO:0005319]; phosphatidylcholine binding [GO:0031210]	cytosol [GO:0005829]; intercellular canaliculus [GO:0046581]; membrane [GO:0016020]; microvillus [GO:0005902]; motile cilium [GO:0031514]	GO:0005319; GO:0005829; GO:0005902; GO:0006656; GO:0016020; GO:0031210; GO:0031514; GO:0046581
GN008006	GN008006.1	Q9R279	54.9	899	897	818	0.0	953	CLCN3_CAVPO	H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3)	Cavia porcellus (Guinea pig)		antiporter activity [GO:0015297]; chloride:proton antiporter activity [GO:0062158]; PDZ domain binding [GO:0030165]; voltage-gated chloride channel activity [GO:0005247]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; vesicle membrane [GO:0012506]	GO:0005247; GO:0005765; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0008021; GO:0010008; GO:0012506; GO:0015297; GO:0030165; GO:0031901; GO:0031902; GO:0055037; GO:0062158
GN008011	GN008011.1	Q80YG3	41.8	297	335	406	6.24e-74	236	KLDC1_MOUSE	Kelch domain-containing protein 1	Mus musculus (Mouse)	protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0016567; GO:0031466; GO:0140627; GO:1990756
GN008012	GN008012.1	Q9UBM8	38.2	348	354	478	1.84e-70	230	MGT4C_HUMAN	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-acetylglucosaminyltransferase IV homolog) (hGnT-IV-H) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GlcNAc-T IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)	Homo sapiens (Human)	protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082]	acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006487; GO:0008375; GO:0008454; GO:0019082
GN008013	GN008013.1	Q8WXK1	26.0	327	488	588	4.53e-13	75.1	ASB15_HUMAN	Ankyrin repeat and SOCS box protein 15 (ASB-15)	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567]		cytosol [GO:0005829]	GO:0005829; GO:0016567; GO:0035556
GN008015	GN008015.1	P57102	48.5	167	184	208	3.98e-37	130	HAND2_DANRE	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND)	Danio rerio (Zebrafish) (Brachydanio rerio)	cardiac muscle cell differentiation [GO:0055007]; cardioblast differentiation [GO:0010002]; cardiocyte differentiation [GO:0035051]; cardiogenic plate morphogenesis [GO:0003142]; determination of intestine left/right asymmetry [GO:0071908]; embryonic heart tube formation [GO:0003144]; embryonic pectoral fin morphogenesis [GO:0035118]; embryonic viscerocranium morphogenesis [GO:0048703]; enteric nervous system development [GO:0048484]; heart contraction [GO:0060047]; heart development [GO:0007507]; heart looping [GO:0001947]; heart morphogenesis [GO:0003007]; noradrenergic neuron differentiation [GO:0003357]; podocyte development [GO:0072015]; polarized epithelial cell differentiation [GO:0030859]; proepicardium development [GO:0003342]; pronephric nephron tubule morphogenesis [GO:0039008]; proximal tubule morphogenesis [GO:0072158]; regulation of transcription by RNA polymerase II [GO:0006357]; sympathetic nervous system development [GO:0048485]; thyroid gland development [GO:0030878]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0001947; GO:0003007; GO:0003142; GO:0003144; GO:0003342; GO:0003357; GO:0005634; GO:0006357; GO:0007507; GO:0010002; GO:0030859; GO:0030878; GO:0035051; GO:0035118; GO:0039008; GO:0046983; GO:0048484; GO:0048485; GO:0048703; GO:0055007; GO:0060047; GO:0071908; GO:0072015; GO:0072158
GN008016	GN008016.1	P22232	83.1	236	319	323	5.87e-144	411	FBRL_XENLA	rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (Histone-glutamine methyltransferase) (U6 snRNA 2'-O-methyltransferase fibrillarin)	Xenopus laevis (African clawed frog)	box C/D sno(s)RNA 3'-end processing [GO:0000494]; ribosomal small subunit biogenesis [GO:0042274]; rRNA methylation [GO:0031167]	histone H2AQ104 methyltransferase activity [GO:1990259]; RNA binding [GO:0003723]; rRNA methyltransferase activity [GO:0008649]; U6 snRNA 2'-O-ribose methyltransferase activity [GO:0180021]	box C/D methylation guide snoRNP complex [GO:0031428]; Cajal body [GO:0015030]; nucleolus [GO:0005730]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]	GO:0000494; GO:0003723; GO:0005634; GO:0005730; GO:0008649; GO:0015030; GO:0031167; GO:0031428; GO:0032040; GO:0042274; GO:0180021; GO:1990259
GN008017	GN008017.1	O15344	29.8	161	475	667	2.11e-09	63.5	TRI18_HUMAN	E3 ubiquitin-protein ligase MID1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)	Homo sapiens (Human)	microtubule cytoskeleton organization [GO:0000226]; pattern specification process [GO:0007389]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein localization to microtubule [GO:0035372]; regulation of microtubule cytoskeleton organization [GO:0070507]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; spindle [GO:0005819]	GO:0000226; GO:0005737; GO:0005819; GO:0005829; GO:0005874; GO:0005875; GO:0007389; GO:0008017; GO:0008270; GO:0019899; GO:0031625; GO:0032874; GO:0035372; GO:0042802; GO:0042803; GO:0051219; GO:0061630; GO:0070507
GN008022	GN008022.1	O43301	25.5	546	489	675	1.55e-29	125	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN008024	GN008024.1	P38552	38.3	287	288	324	2.74e-56	187	LEG4_RAT	Galectin-4 (Gal-4) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4)	Rattus norvegicus (Rat)	antibacterial peptide biosynthetic process [GO:0002780]; defense response to bacterium [GO:0042742]	carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936]	extracellular region [GO:0005576]	GO:0002780; GO:0005576; GO:0016936; GO:0030246; GO:0042742
GN008025	GN008025.1	Q29058	32.4	142	224	323	7.81e-13	69.7	LEG4_PIG	Galectin-4 (Gal-4) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4)	Sus scrofa (Pig)		carbohydrate binding [GO:0030246]		GO:0030246
GN008027	GN008027.1	P86952	32.5	317	952	456	8.71e-41	160	TYRO_PINMA	Tyrosinase-like protein (Tyrosinase-2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN008029	GN008029.1	G8JYB2	46.9	687	828	784	4.79e-184	550	CTNL1_CAEEL	Alpha-catulin	Caenorhabditis elegans	cell adhesion [GO:0007155]; regulation of locomotion [GO:0040012]; Rho protein signal transduction [GO:0007266]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]	plasma membrane [GO:0005886]; striated muscle dense body [GO:0055120]	GO:0005886; GO:0007155; GO:0007266; GO:0040012; GO:0045296; GO:0051015; GO:0055120
GN008030	GN008030.1	Q93654	37.9	153	441	245	4.34e-20	92.4	GRAS1_CAEEL	General receptor for phosphoinositides 1-associated scaffold protein 1 homolog	Caenorhabditis elegans			nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0005634; GO:0005886; GO:0048471
GN008033	GN008033.1	Q96SJ8	30.7	189	261	248	6.22e-15	75.5	TSN18_HUMAN	Tetraspanin-18 (Tspan-18)	Homo sapiens (Human)	calcium-ion regulated exocytosis [GO:0017156]; calcium-mediated signaling [GO:0019722]; inflammatory response [GO:0006954]; protein localization to cell periphery [GO:1990778]; regulation of sprouting angiogenesis [GO:1903670]; regulation of store-operated calcium entry [GO:2001256]	transmembrane transporter binding [GO:0044325]	cell periphery [GO:0071944]; plasma membrane [GO:0005886]	GO:0005886; GO:0006954; GO:0017156; GO:0019722; GO:0044325; GO:0071944; GO:1903670; GO:1990778; GO:2001256
GN008034	GN008034.1	P51049	28.7	345	353	347	2.13e-28	116	MR1BB_DANRE	Melatonin receptor type 1B-B (Mel-1B-R-B) (Mel1b receptor B) (Melatonin receptor Mel1b Z2.6-4) (zMel1b-1)	Danio rerio (Zebrafish) (Brachydanio rerio)	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of insulin secretion [GO:0050796]	G protein-coupled receptor activity [GO:0004930]; melatonin receptor activity [GO:0008502]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007186; GO:0008502; GO:0050796
GN008035	GN008035.1	Q60997	26.9	501	692	2085	4.67e-29	128	DMBT1_MOUSE	Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Apactin) (CRP-ductin) (Deleted in malignant brain tumors 1 protein) (Glycoprotein 300) (gp300) (Hensin) (Mucin-like glycoprotein) (Muclin) (Vomeroglandin) (p80)	Mus musculus (Mouse)	antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; blastocyst development [GO:0001824]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; induction of bacterial agglutination [GO:0043152]; inner cell mass cell proliferation [GO:0001833]; positive regulation of epithelial cell differentiation [GO:0030858]; receptor-mediated endocytosis [GO:0006898]; response to bacterium [GO:0009617]	DNA binding [GO:0003677]; heparan sulfate binding [GO:1904399]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]; phagocytic vesicle membrane [GO:0030670]; transport vesicle membrane [GO:0030658]; zymogen granule membrane [GO:0042589]	GO:0001530; GO:0001824; GO:0001833; GO:0003677; GO:0005044; GO:0005576; GO:0005737; GO:0006898; GO:0009617; GO:0030658; GO:0030670; GO:0030858; GO:0031012; GO:0035375; GO:0038187; GO:0042589; GO:0043152; GO:0050829; GO:0050830; GO:0061844; GO:0070891; GO:0140144; GO:1904399
GN008039	GN008039.1	Q02153	63.5	609	612	619	7.99e-283	787	GCYB1_HUMAN	Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit)	Homo sapiens (Human)	cellular response to nitric oxide [GO:0071732]; cGMP biosynthetic process [GO:0006182]; nitric oxide-cGMP-mediated signaling [GO:0038060]; response to oxygen levels [GO:0070482]	adenylate cyclase activity [GO:0004016]; cytidylate cyclase activity [GO:0047805]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; Hsp90 protein binding [GO:0051879]; nitric oxide binding [GO:0070026]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; guanylate cyclase complex, soluble [GO:0008074]; presynaptic active zone cytoplasmic component [GO:0098831]	GO:0004016; GO:0004383; GO:0005737; GO:0005829; GO:0006182; GO:0008074; GO:0020037; GO:0038060; GO:0044877; GO:0047805; GO:0051879; GO:0070026; GO:0070482; GO:0071732; GO:0098831; GO:0098978
GN008040	GN008040.1	Q9WVI4	72.9	85	118	730	2.88e-37	136	GCYA2_RAT	Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2)	Rattus norvegicus (Rat)	intracellular signal transduction [GO:0035556]; response to oxygen levels [GO:0070482]	guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; protein-containing complex binding [GO:0044877]	cytosol [GO:0005829]; guanylate cyclase complex, soluble [GO:0008074]	GO:0004383; GO:0005829; GO:0008074; GO:0020037; GO:0035556; GO:0044877; GO:0070482
GN008041	GN008041.1	Q24292	35.7	3381	3280	3556	0.0	1710	DS_DROME	Protein dachsous (Adherin)	Drosophila melanogaster (Fruit fly)	axonogenesis [GO:0007409]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; homophilic cell-cell adhesion [GO:0007156]; imaginal disc morphogenesis [GO:0007560]; negative regulation of hippo signaling [GO:0035331]; positive regulation of hippo signaling [GO:0035332]; protein localization involved in establishment of planar polarity [GO:0090251]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; apicolateral plasma membrane [GO:0016327]; plasma membrane [GO:0005886]	GO:0001736; GO:0005509; GO:0005886; GO:0005912; GO:0007156; GO:0007409; GO:0007560; GO:0016327; GO:0030855; GO:0035331; GO:0035332; GO:0042067; GO:0044331; GO:0070161; GO:0090251
GN008042	GN008042.1	F4KD71	27.5	705	772	704	1.31e-67	240	DUR3_ARATH	Urea-proton symporter DUR3 (AtDUR3) (High-affinity urea active transporter DUR3)	Arabidopsis thaliana (Mouse-ear cress)	cellular response to nitrogen starvation [GO:0006995]; urea transmembrane transport [GO:0071918]	urea binding [GO:0033219]; urea transmembrane transporter activity [GO:0015204]	chloroplast [GO:0009507]; plasma membrane [GO:0005886]	GO:0005886; GO:0006995; GO:0009507; GO:0015204; GO:0033219; GO:0071918
GN008043	GN008043.1	A0A345BJN8	24.4	221	331	919	3.81e-10	64.7	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN008045	GN008045.1	Q9NVA4	49.3	410	487	438	8.51e-133	394	T184C_HUMAN	Transmembrane protein 184C (Transmembrane protein 34)	Homo sapiens (Human)		transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0016020; GO:0022857
GN008046	GN008046.1	A0JNJ3	31.9	626	576	668	8.26e-75	254	SPART_BOVIN	Spartin	Bos taurus (Bovine)	cell division [GO:0051301]; lipid transport [GO:0006869]; lipophagy [GO:0061724]; negative regulation of BMP signaling pathway [GO:0030514]	lipid binding [GO:0008289]	cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; midbody [GO:0030496]; plasma membrane [GO:0005886]	GO:0005737; GO:0005811; GO:0005886; GO:0006869; GO:0008289; GO:0030496; GO:0030514; GO:0051301; GO:0061724
GN008047	GN008047.1	P33450	33.3	3410	3225	5147	0.0	1540	FAT_DROME	Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito]	Drosophila melanogaster (Fruit fly)	axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; equator specification [GO:0045317]; establishment of body hair planar orientation [GO:0048105]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of polarity of larval imaginal disc epithelium [GO:0016336]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; imaginal disc-derived wing morphogenesis [GO:0007476]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of growth [GO:0045926]; negative regulation of imaginal disc growth [GO:0045571]; negative regulation of organ growth [GO:0046621]; positive regulation of apoptotic process [GO:0043065]; positive regulation of hippo signaling [GO:0035332]; protein localization involved in establishment of planar polarity [GO:0090251]; pupal development [GO:0035209]; regulation of establishment of planar polarity [GO:0090175]; regulation of growth [GO:0040008]; regulation of imaginal disc growth [GO:0045570]; regulation of protein localization [GO:0032880]; regulation of tube length, open tracheal system [GO:0035159]; tissue development [GO:0009888]; wing disc development [GO:0035220]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0001736; GO:0001737; GO:0005509; GO:0005739; GO:0005886; GO:0005912; GO:0007156; GO:0007157; GO:0007164; GO:0007409; GO:0007446; GO:0007447; GO:0007476; GO:0008285; GO:0009888; GO:0010629; GO:0016324; GO:0016327; GO:0016336; GO:0016339; GO:0030855; GO:0032880; GO:0035159; GO:0035209; GO:0035220; GO:0035332; GO:0040008; GO:0042067; GO:0043065; GO:0044331; GO:0045296; GO:0045317; GO:0045570; GO:0045571; GO:0045926; GO:0046621; GO:0048105; GO:0090175; GO:0090176; GO:0090251; GO:0098609
GN008048	GN008048.1	Q2PZL6	37.2	1679	1724	4981	1.55e-304	974	FAT4_MOUSE	Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J)	Mus musculus (Mouse)	axonogenesis [GO:0007409]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell adhesion mediated by cadherin [GO:0044331]; cerebral cortex development [GO:0021987]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; epithelial cell differentiation [GO:0030855]; establishment of planar polarity [GO:0001736]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell-cell adhesion [GO:0007156]; inner ear receptor cell stereocilium organization [GO:0060122]; kidney development [GO:0001822]; nephron development [GO:0072006]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; plasma membrane [GO:0005886]	GO:0001658; GO:0001736; GO:0001822; GO:0003007; GO:0005509; GO:0005886; GO:0005912; GO:0007009; GO:0007156; GO:0007157; GO:0007219; GO:0007409; GO:0008543; GO:0021987; GO:0022008; GO:0030855; GO:0035329; GO:0043931; GO:0044331; GO:0045177; GO:0048565; GO:0060122; GO:0072006; GO:0072137; GO:0072307
GN008049	GN008049.1	Q99715	36.5	178	394	3063	6.22e-21	99.0	COCA1_HUMAN	Collagen alpha-1(XII) chain	Homo sapiens (Human)	collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen type XII trimer [GO:0005595]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]	GO:0005576; GO:0005595; GO:0005788; GO:0030020; GO:0030199; GO:0031012; GO:0035987; GO:0070062; GO:1903561
GN008051	GN008051.1	Q9R0M6	66.5	203	205	201	1.70e-92	271	RAB9A_MOUSE	Ras-related protein Rab-9A (EC 3.6.5.2) (Sid 99)	Mus musculus (Mouse)	positive regulation of exocytosis [GO:0045921]; Rab protein signal transduction [GO:0032482]; receptor-mediated endocytosis [GO:0006898]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]	cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	GO:0000139; GO:0003924; GO:0003925; GO:0005525; GO:0005764; GO:0005770; GO:0005789; GO:0005829; GO:0005886; GO:0006898; GO:0019003; GO:0030659; GO:0030670; GO:0032482; GO:0032880; GO:0042147; GO:0042470; GO:0042802; GO:0045335; GO:0045921
GN008052	GN008052.1	P79942	47.1	310	318	388	1.46e-86	268	NOCT_XENLA	Nocturnin (EC 3.1.3.-) (Carbon catabolite repression 4-like protein) (Rhythmic message 1) (RM1)	Xenopus laevis (African clawed frog)	circadian rhythm [GO:0007623]; mRNA catabolic process [GO:0006402]; NADP+ metabolic process [GO:0006739]	3'-5'-RNA exonuclease activity [GO:0000175]; NADP phosphatase activity [GO:0019178]; NADPH phosphatase activity [GO:0102757]; poly(A)-specific ribonuclease activity [GO:0004535]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0000175; GO:0004535; GO:0005634; GO:0005737; GO:0005739; GO:0006402; GO:0006739; GO:0007623; GO:0019178; GO:0048471; GO:0102757
GN008053	GN008053.1	Q96M89	37.1	490	563	665	1.79e-79	266	CC138_HUMAN	Coiled-coil domain-containing protein 138	Homo sapiens (Human)				
GN008054	GN008054.1	E1BNQ4	59.7	236	243	329	2.28e-98	293	NNRD_BOVIN	ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase)	Bos taurus (Bovine)	metabolite repair [GO:0110051]; nicotinamide nucleotide metabolic process [GO:0046496]	ATP-dependent NAD(P)H-hydrate dehydratase activity [GO:0047453]	mitochondrion [GO:0005739]	GO:0005739; GO:0046496; GO:0047453; GO:0110051
GN008055	GN008055.1	Q9BZA7	33.0	781	1164	1347	8.24e-111	380	PC11X_HUMAN	Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S)	Homo sapiens (Human)	cell adhesion [GO:0007155]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0050839
GN008056	GN008056.1	Q6KEQ9	32.4	766	1146	1117	6.70e-107	365	PC11X_PIG	Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X)	Sus scrofa (Pig)	cell adhesion [GO:0007155]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0050839
GN008058	GN008058.1	Q8CBH5	22.7	633	662	775	3.39e-31	133	MFSD6_MOUSE	Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2)	Mus musculus (Mouse)	antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]	MHC class I protein binding [GO:0042288]; MHC class I receptor activity [GO:0032393]	plasma membrane [GO:0005886]	GO:0005886; GO:0032393; GO:0042288; GO:0042590
GN008059	GN008059.1	A5PJA8	48.8	170	182	241	2.11e-49	162	EMC7_BOVIN	Endoplasmic reticulum membrane protein complex subunit 7 (ER membrane protein complex subunit 7)	Bos taurus (Bovine)	protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	carbohydrate binding [GO:0030246]	EMC complex [GO:0072546]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0005789; GO:0016020; GO:0030246; GO:0045050; GO:0071816; GO:0072546
GN008061	GN008061.1	B2RXA1	38.3	313	313	340	5.77e-70	223	PLCX2_MOUSE	PI-PLC X domain-containing protein 2 (Phospholipase C X-domain containing protein 2) (PLCXD-2)	Mus musculus (Mouse)	lipid metabolic process [GO:0006629]	phosphoric diester hydrolase activity [GO:0008081]	nucleus [GO:0005634]	GO:0005634; GO:0006629; GO:0008081
GN008062	GN008062.1	Q01768	70.9	151	153	152	3.34e-77	229	NDKB_MOUSE	Nucleoside diphosphate kinase B (NDP kinase B) (NDPK B) (EC 2.7.4.6) (Histidine protein kinase NDKB) (EC 2.7.13.3) (Nucleoside diphosphate kinases 2) (NDPK2) (P18) (nm23-M2)	Mus musculus (Mouse)	CTP biosynthetic process [GO:0006241]; dTMP biosynthetic process [GO:0006231]; GTP biosynthetic process [GO:0006183]; integrin-mediated signaling pathway [GO:0007229]; nucleoside triphosphate biosynthetic process [GO:0009142]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of fatty acid biosynthetic process [GO:0042304]; UTP biosynthetic process [GO:0006228]	coenzyme A binding [GO:0120225]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; enzyme binding [GO:0019899]; fatty acid binding [GO:0005504]; G-quadruplex DNA binding [GO:0051880]; GDP binding [GO:0019003]; heterocyclic compound binding [GO:1901363]; identical protein binding [GO:0042802]; intermediate filament binding [GO:0019215]; kinase activity [GO:0016301]; nucleoside diphosphate kinase activity [GO:0004550]; protein histidine kinase activity [GO:0004673]; protein serine/threonine kinase activity [GO:0004674]	cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; lamellipodium [GO:0030027]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ruffle [GO:0001726]	GO:0001216; GO:0001726; GO:0003677; GO:0004550; GO:0004673; GO:0004674; GO:0005504; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005882; GO:0006183; GO:0006228; GO:0006231; GO:0006241; GO:0007229; GO:0009142; GO:0016301; GO:0019003; GO:0019215; GO:0019899; GO:0030027; GO:0031966; GO:0042304; GO:0042802; GO:0043209; GO:0045893; GO:0045944; GO:0048471; GO:0051880; GO:0071944; GO:0120225; GO:1901363
GN008067	GN008067.1	Q9X248	40.1	247	260	246	2.67e-44	152	FABG_THEMA	3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase)	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	fatty acid elongation [GO:0030497]	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; NAD binding [GO:0051287]; NADP binding [GO:0050661]		GO:0004316; GO:0030497; GO:0050661; GO:0051287
GN008068	GN008068.1	Q9D8U8	25.7	369	411	404	4.41e-26	112	SNX5_MOUSE	Sorting nexin-5	Mus musculus (Mouse)	endosome membrane tubulation [GO:0097750]; epidermal growth factor catabolic process [GO:0007174]; intracellular protein transport [GO:0006886]; negative regulation of blood pressure [GO:0045776]; pinocytosis [GO:0006907]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin receptor signaling pathway [GO:0046628]; retrograde transport, endosome to Golgi [GO:0042147]	D1 dopamine receptor binding [GO:0031748]; dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]	brush border [GO:0005903]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; macropinocytic cup [GO:0070685]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; ruffle [GO:0001726]; tubular endosome [GO:0097422]	GO:0001726; GO:0001891; GO:0005768; GO:0005769; GO:0005829; GO:0005886; GO:0005903; GO:0006886; GO:0006907; GO:0007174; GO:0009898; GO:0010008; GO:0010314; GO:0030904; GO:0030905; GO:0031748; GO:0031901; GO:0034452; GO:0035091; GO:0042147; GO:0045776; GO:0045893; GO:0046628; GO:0048471; GO:0070273; GO:0070685; GO:0080025; GO:0097422; GO:0097750; GO:0098559
GN008069	GN008069.1	Q5ZMD4	27.4	288	612	408	8.75e-21	98.6	TRI59_CHICK	Tripartite motif-containing protein 59	Gallus gallus (Chicken)	innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0008270; GO:0043124; GO:0045087; GO:0061630
GN008070	GN008070.1	Q6F6U3	40.0	200	340	214	5.38e-35	130	PNCA_ACIAD	Nicotinamidase (EC 3.5.1.19) (Nicotinamide deamidase) (NAMase)	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)		nicotinamidase activity [GO:0008936]		GO:0008936
GN008073	GN008073.1	P20105	75.4	126	423	829	2.65e-53	193	E74EA_DROME	Ecdysone-induced protein 74EF isoform A (ETS-related protein E74A)	Drosophila melanogaster (Fruit fly)	autophagic cell death [GO:0048102]; autophagy [GO:0006914]; oogenesis [GO:0048477]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of development, heterochronic [GO:0040034]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0001228; GO:0005634; GO:0006914; GO:0040034; GO:0043565; GO:0045944; GO:0048102; GO:0048477
GN008076	GN008076.1	Q8BGV0	49.3	438	436	477	5.32e-151	440	SYNM_MOUSE	Asparaginyl-tRNA synthetase (AsnRS) (NARS2) (EC 6.1.1.22) (Asparagine--tRNA ligase, mitochondrial)	Mus musculus (Mouse)	asparaginyl-tRNA aminoacylation [GO:0006421]	asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0003676; GO:0004816; GO:0005524; GO:0005654; GO:0005739; GO:0005759; GO:0005829; GO:0006421
GN008077	GN008077.1	Q8R034	65.3	72	75	74	3.45e-27	96.7	APC13_MOUSE	Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13)	Mus musculus (Mouse)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]		anaphase-promoting complex [GO:0005680]	GO:0005680; GO:0031145; GO:0070936; GO:0070979; GO:0141198
GN008078	GN008078.1	Q3T094	56.4	243	313	254	5.11e-98	292	ETHE1_BOVIN	Persulfide dioxygenase ETHE1, mitochondrial (EC 1.13.11.18) (Sulfur dioxygenase ETHE1)	Bos taurus (Bovine)	glutathione metabolic process [GO:0006749]; hydrogen sulfide metabolic process [GO:0070813]; sulfide oxidation [GO:0019418]	iron ion binding [GO:0005506]; sulfur dioxygenase activity [GO:0050313]	mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]	GO:0005506; GO:0005634; GO:0005759; GO:0006749; GO:0019418; GO:0050313; GO:0070813
GN008079	GN008079.1	Q8BGJ9	84.5	161	160	220	4.42e-99	287	U2AF4_MOUSE	Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4)	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]	metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701]	GO:0000398; GO:0005634; GO:0005681; GO:0005737; GO:0016607; GO:0030628; GO:0046872; GO:0089701
GN008080	GN008080.1	Q96M20	28.8	198	693	576	3.45e-15	82.8	CNBD2_HUMAN	Cyclic nucleotide-binding domain-containing protein 2	Homo sapiens (Human)	spermatogenesis [GO:0007283]	cAMP binding [GO:0030552]	cytosol [GO:0005829]; sperm midpiece [GO:0097225]	GO:0005829; GO:0007283; GO:0030552; GO:0097225
GN008081	GN008081.1	Q14AW5	41.0	451	706	724	1.09e-98	322	NSUN7_MOUSE	Protein NSUN7 (NOL1/NOP2/Sun domain family member 7)	Mus musculus (Mouse)	flagellated sperm motility [GO:0030317]; sperm flagellum assembly [GO:0120316]; sperm mitochondrion organization [GO:0030382]	methyltransferase activity [GO:0008168]	cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]	GO:0005737; GO:0008168; GO:0030317; GO:0030382; GO:0036126; GO:0120316
GN008082	GN008082.1	Q63931	31.3	230	253	430	1.67e-26	109	CCKAR_CAVPO	Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R)	Cavia porcellus (Guinea pig)		cholecystokinin receptor activity [GO:0004951]; neuropeptide receptor activity [GO:0008188]; peptide hormone binding [GO:0017046]	plasma membrane [GO:0005886]	GO:0004951; GO:0005886; GO:0008188; GO:0017046
GN008083	GN008083.1	O74508	37.8	111	503	424	6.89e-10	64.7	SPP1_SCHPO	Set1 complex component spp1 (Set1C component spp1) (COMPASS component spp1) (Complex proteins associated with set1 protein spp1)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	positive regulation of DNA-templated transcription [GO:0045893]; subtelomeric heterochromatin formation [GO:0031509]; transcription initiation-coupled chromatin remodeling [GO:0045815]		chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]	GO:0000781; GO:0000785; GO:0005634; GO:0005829; GO:0031509; GO:0045815; GO:0045893; GO:0048188
GN008084	GN008084.1	Q4SQJ2	40.4	94	124	104	2.46e-13	64.3	LYRM7_TETNG	Complex III assembly factor LYRM7 (LYR motif-containing protein 7)	Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)	mitochondrial respiratory chain complex III assembly [GO:0034551]	protein folding chaperone [GO:0044183]	mitochondrial matrix [GO:0005759]	GO:0005759; GO:0034551; GO:0044183
GN008088	GN008088.1	D3Z902	64.7	573	780	713	3.77e-105	341	FBXW7_RAT	F-box/WD repeat-containing protein 7	Rattus norvegicus (Rat)	cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; lung development [GO:0030324]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of osteoclast development [GO:2001205]; Notch signaling pathway [GO:0007219]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein localization to mitochondrion [GO:1903749]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; protein K63-linked ubiquitination [GO:0070534]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of circadian rhythm [GO:0042752]; regulation of mitophagy [GO:1901524]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; sister chromatid cohesion [GO:0007062]; ubiquitin recycling [GO:0010992]; vasculogenesis [GO:0001570]	cyclin binding [GO:0030332]; identical protein binding [GO:0042802]; phosphothreonine residue binding [GO:0050816]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activator activity [GO:0097027]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005]	GO:0001570; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0005739; GO:0005783; GO:0005794; GO:0006974; GO:0007062; GO:0007219; GO:0010629; GO:0010992; GO:0016567; GO:0019005; GO:0030324; GO:0030332; GO:0030674; GO:0031146; GO:0031398; GO:0031625; GO:0031648; GO:0032991; GO:0034644; GO:0042752; GO:0042802; GO:0043130; GO:0043161; GO:0045742; GO:0045746; GO:0048471; GO:0050816; GO:0050821; GO:0070374; GO:0070534; GO:0090049; GO:0097027; GO:1901524; GO:1901800; GO:1903378; GO:1903749; GO:1990452; GO:1990756; GO:2000060; GO:2001205
GN008089	GN008089.1	P52486	73.4	199	199	199	6.12e-107	308	UBCD4_DROME	Ubiquitin-conjugating enzyme E2-22 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein) (Ubiquitin-protein ligase)	Drosophila melanogaster (Fruit fly)	positive regulation of peptidoglycan recognition protein signaling pathway [GO:0061059]; protein polyubiquitination [GO:0000209]	proteasome binding [GO:0070628]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]		GO:0000209; GO:0004842; GO:0031625; GO:0061059; GO:0061631; GO:0070628
GN008094	GN008094.1	Q9DGG6	49.6	472	499	1334	6.55e-133	419	ADCY9_CHICK	Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (Adenylyl cyclase 9)	Gallus gallus (Chicken)	adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556]	adenylate cyclase activity [GO:0004016]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004016; GO:0005886; GO:0006171; GO:0007189; GO:0016020; GO:0035556; GO:0071880
GN008095	GN008095.1	Q9DGG6	43.7	531	712	1334	1.70e-124	405	ADCY9_CHICK	Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (Adenylyl cyclase 9)	Gallus gallus (Chicken)	adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cAMP biosynthetic process [GO:0006171]; intracellular signal transduction [GO:0035556]	adenylate cyclase activity [GO:0004016]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004016; GO:0005886; GO:0006171; GO:0007189; GO:0016020; GO:0035556; GO:0071880
GN008097	GN008097.1	P12613	76.8	556	556	557	1.63e-297	820	TCPA_DROME	T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) (Chaperonin containing TCP1 subunit 1)	Drosophila melanogaster (Fruit fly)	follicle cell of egg chamber development [GO:0030707]; protein folding [GO:0006457]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]	chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]	GO:0005524; GO:0005829; GO:0005832; GO:0006457; GO:0016887; GO:0030707; GO:0140662
GN008098	GN008098.1	P32896	23.9	418	545	925	3.03e-20	98.6	PDC2_YEAST	Protein PDC2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	positive regulation of glycolytic fermentation to ethanol [GO:2001172]; positive regulation of thiamine biosynthetic process [GO:0090180]; positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA binding [GO:0003677]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0003677; GO:0005634; GO:0045944; GO:0090180; GO:2001172
GN008099	GN008099.1	Q6NXJ0	37.2	1267	1230	1187	1.12e-153	495	WWC2_MOUSE	Protein WWC2 (WW domain-containing protein 2)	Mus musculus (Mouse)	cell migration [GO:0016477]; hippo signaling [GO:0035329]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]; regulation of hippo signaling [GO:0035330]	kinase binding [GO:0019900]; molecular adaptor activity [GO:0060090]; signaling adaptor activity [GO:0035591]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0000122; GO:0005737; GO:0005829; GO:0006355; GO:0008285; GO:0016477; GO:0019900; GO:0035329; GO:0035330; GO:0035331; GO:0035591; GO:0046621; GO:0060090
GN008100	GN008100.1	Q5SXM2	29.5	268	314	1469	6.08e-11	67.0	SNPC4_HUMAN	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit)	Homo sapiens (Human)	snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]	DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; snRNA-activating protein complex [GO:0019185]	GO:0000995; GO:0001006; GO:0003677; GO:0005634; GO:0005654; GO:0016251; GO:0019185; GO:0042795; GO:0042796
GN008102	GN008102.1	Q54NA6	40.7	221	1247	855	1.37e-42	172	MYBL_DICDI	Myb-like protein L	Dictyostelium discoideum (Social amoeba)	snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]	RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]	nucleus [GO:0005634]; snRNA-activating protein complex [GO:0019185]	GO:0001006; GO:0005634; GO:0019185; GO:0042795; GO:0042796
GN008104	GN008104.1	Q9H5L6	35.3	116	117	903	2.31e-15	73.9	THAP9_HUMAN	DNA transposase THAP9 (EC 2.7.7.-) (THAP domain-containing protein 9) (hTh9)	Homo sapiens (Human)	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA transposition [GO:0006313]	DNA binding [GO:0003677]; sequence-specific DNA binding [GO:0043565]; transposase activity [GO:0004803]		GO:0003677; GO:0004803; GO:0006310; GO:0006313; GO:0015074; GO:0043565
GN008106	GN008106.1	Q5Q0U0	45.9	390	418	495	7.99e-121	363	S17A5_RAT	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Solute carrier family 17 (Anion/sugar transporter), member 5) (Vesicular excitatory amino acid transporter) (VEAT)	Rattus norvegicus (Rat)	neurotransmitter loading into synaptic vesicle [GO:0098700]; response to bacterium [GO:0009617]; sialic acid transport [GO:0015739]	D-glucuronate transmembrane transporter activity [GO:0042880]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle [GO:0031410]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	GO:0005764; GO:0005765; GO:0005886; GO:0009617; GO:0015136; GO:0015538; GO:0015739; GO:0016323; GO:0016324; GO:0030672; GO:0031410; GO:0042880; GO:0098700; GO:0098978
GN008108	GN008108.1	P90884	35.5	124	755	1045	4.04e-13	77.0	MADD4_CAEEL	Protein madd-4 (Punctin)	Caenorhabditis elegans	dorsal/ventral axon guidance [GO:0033563]; extracellular matrix organization [GO:0030198]; synapse organization [GO:0050808]	signaling receptor binding [GO:0005102]	axon [GO:0030424]; extracellular region [GO:0005576]; synapse [GO:0045202]	GO:0005102; GO:0005576; GO:0030198; GO:0030424; GO:0033563; GO:0045202; GO:0050808
GN008109	GN008109.1	A0A345BJN8	25.6	347	538	919	5.41e-22	103	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN008110	GN008110.1	Q96E35	53.5	159	202	227	3.43e-53	172	ZMY19_HUMAN	Zinc finger MYND domain-containing protein 19 (Melanin-concentrating hormone receptor 1-interacting zinc finger protein) (MCH-R1-interacting zinc finger protein)	Homo sapiens (Human)			cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0005737; GO:0005886; GO:0016020; GO:0045202
GN008111	GN008111.1	A4IF63	23.6	554	637	744	3.54e-22	105	TRIM2_BOVIN	Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2)	Bos taurus (Bovine)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0043161; GO:0043523; GO:0061630
GN008115	GN008115.1	Q2HJ58	90.5	168	188	318	3.48e-102	300	PRPS1_BOVIN	Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase I) (PRS-I)	Bos taurus (Bovine)	5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; purine nucleotide biosynthetic process [GO:0006164]; ribonucleoside monophosphate biosynthetic process [GO:0009156]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749]	cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189]	GO:0000287; GO:0002189; GO:0004749; GO:0005524; GO:0005737; GO:0006015; GO:0006164; GO:0009156; GO:0042803
GN008125	GN008125.1	Q6R2W3	29.9	204	929	1325	2.68e-15	84.7	SCND3_HUMAN	SCAN domain-containing protein 3 (Transposon-derived Buster4 transposase-like protein) (Zinc finger BED domain-containing protein 9)	Homo sapiens (Human)	DNA integration [GO:0015074]; positive regulation of cell cycle [GO:0045787]; positive regulation of epithelial cell proliferation [GO:0050679]	nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003676; GO:0005634; GO:0005737; GO:0015074; GO:0045787; GO:0050679
GN008134	GN008134.1	Q8K0U4	32.6	503	459	675	1.04e-76	255	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN008146	GN008146.1	Q9BZA8	34.7	767	932	1340	1.74e-112	379	PC11Y_HUMAN	Protocadherin-11 Y-linked (Protocadherin-11) (Protocadherin on the Y chromosome) (PCDH-Y) (Protocadherin prostate cancer) (Protocadherin-PC) (Protocadherin-22)	Homo sapiens (Human)	cell adhesion [GO:0007155]; homophilic cell-cell adhesion [GO:0007156]; positive regulation of Wnt signaling pathway [GO:0030177]; spermatogenesis [GO:0007283]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	plasma membrane [GO:0005886]; sperm head [GO:0061827]; sperm midpiece [GO:0097225]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0007283; GO:0030177; GO:0050839; GO:0061827; GO:0097225
GN008147	GN008147.1	F8W3X3	32.4	657	886	1088	1.29e-93	322	PCD19_DANRE	Protocadherin-19	Danio rerio (Zebrafish) (Brachydanio rerio)	brain morphogenesis [GO:0048854]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; excitatory postsynaptic potential [GO:0060079]; homophilic cell-cell adhesion [GO:0007156]; neural tube formation [GO:0001841]; regulation of neuronal action potential [GO:0098908]; visual perception [GO:0007601]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]	membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	GO:0001841; GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0007601; GO:0016020; GO:0042802; GO:0045296; GO:0048854; GO:0050839; GO:0060079; GO:0098609; GO:0098794; GO:0098908
GN008148	GN008148.1	Q80TF3	33.1	709	1115	1145	1.50e-91	322	PCD19_MOUSE	Protocadherin-19	Mus musculus (Mouse)	cell adhesion [GO:0007155]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0050839
GN008149	GN008149.1	Q9HC56	32.7	749	1134	1237	2.54e-106	365	PCDH9_HUMAN	Protocadherin-9	Homo sapiens (Human)	cell adhesion [GO:0007155]; forebrain development [GO:0030900]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0030900; GO:0050839; GO:0097060; GO:0098978
GN008150	GN008150.1	Q56R14	27.9	111	502	1091	9.53e-10	65.1	TRI33_XENLA	E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)	Xenopus laevis (African clawed frog)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0008270; GO:0016567; GO:0061630
GN008151	GN008151.1	Q9HC56	33.4	760	1053	1237	8.22e-122	406	PCDH9_HUMAN	Protocadherin-9	Homo sapiens (Human)	cell adhesion [GO:0007155]; forebrain development [GO:0030900]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0030900; GO:0050839; GO:0097060; GO:0098978
GN008152	GN008152.1	Q9BZA8	32.9	765	1042	1340	6.32e-110	375	PC11Y_HUMAN	Protocadherin-11 Y-linked (Protocadherin-11) (Protocadherin on the Y chromosome) (PCDH-Y) (Protocadherin prostate cancer) (Protocadherin-PC) (Protocadherin-22)	Homo sapiens (Human)	cell adhesion [GO:0007155]; homophilic cell-cell adhesion [GO:0007156]; positive regulation of Wnt signaling pathway [GO:0030177]; spermatogenesis [GO:0007283]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	plasma membrane [GO:0005886]; sperm head [GO:0061827]; sperm midpiece [GO:0097225]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0007283; GO:0030177; GO:0050839; GO:0061827; GO:0097225
GN008153	GN008153.1	Q6X862	31.2	749	1098	1347	3.45e-99	346	PC11X_GORGO	Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome)	Gorilla gorilla gorilla (Western lowland gorilla)	cell adhesion [GO:0007155]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0050839
GN008154	GN008154.1	Q9HC56	34.9	682	1015	1237	7.06e-113	380	PCDH9_HUMAN	Protocadherin-9	Homo sapiens (Human)	cell adhesion [GO:0007155]; forebrain development [GO:0030900]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0030900; GO:0050839; GO:0097060; GO:0098978
GN008155	GN008155.1	Q9HC56	34.3	721	1043	1237	9.17e-113	381	PCDH9_HUMAN	Protocadherin-9	Homo sapiens (Human)	cell adhesion [GO:0007155]; forebrain development [GO:0030900]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0030900; GO:0050839; GO:0097060; GO:0098978
GN008156	GN008156.1	Q6WYY1	31.4	757	1100	1347	6.19e-94	331	PC11X_PANPA	Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X)	Pan paniscus (Pygmy chimpanzee) (Bonobo)	homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]	plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0007156
GN008158	GN008158.1	O75592	48.0	254	251	4678	1.70e-85	281	MYCB2_HUMAN	E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Protein associated with Myc)	Homo sapiens (Human)	axon guidance [GO:0007411]; central nervous system projection neuron axonogenesis [GO:0021952]; circadian regulation of gene expression [GO:0032922]; neuromuscular process [GO:0050905]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of axon guidance [GO:1902667]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; synaptic assembly at neuromuscular junction [GO:0051124]	guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	axon [GO:0030424]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005085; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0007411; GO:0008270; GO:0008582; GO:0015630; GO:0016020; GO:0016567; GO:0021952; GO:0030424; GO:0031267; GO:0031398; GO:0032922; GO:0042802; GO:0043161; GO:0050905; GO:0051124; GO:0061630; GO:0070936; GO:1902667
GN008159	GN008159.1	O75592	47.4	4179	4012	4678	0.0	3378	MYCB2_HUMAN	E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Protein associated with Myc)	Homo sapiens (Human)	axon guidance [GO:0007411]; central nervous system projection neuron axonogenesis [GO:0021952]; circadian regulation of gene expression [GO:0032922]; neuromuscular process [GO:0050905]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of axon guidance [GO:1902667]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; synaptic assembly at neuromuscular junction [GO:0051124]	guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	axon [GO:0030424]; cytoplasm [GO:0005737]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005085; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0007411; GO:0008270; GO:0008582; GO:0015630; GO:0016020; GO:0016567; GO:0021952; GO:0030424; GO:0031267; GO:0031398; GO:0032922; GO:0042802; GO:0043161; GO:0050905; GO:0051124; GO:0061630; GO:0070936; GO:1902667
GN008160	GN008160.1	A2VDD2	33.8	139	195	176	8.93e-25	98.2	DYL5B_XENLA	Dynein light chain Tctex-type 5-B (Tctex1 domain-containing protein 1-B)	Xenopus laevis (African clawed frog)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505
GN008163	GN008163.1	Q3B736	63.5	200	203	218	1.19e-93	275	ATGA1_DANRE	Autophagy-related protein 101	Danio rerio (Zebrafish) (Brachydanio rerio)	autophagosome assembly [GO:0000045]	protein kinase binding [GO:0019901]	Atg1/ULK1 kinase complex [GO:1990316]; cytoplasm [GO:0005737]; phagophore assembly site [GO:0000407]	GO:0000045; GO:0000407; GO:0005737; GO:0019901; GO:1990316
GN008167	GN008167.1	Q4R5Y0	44.7	123	152	150	1.59e-31	113	CFA68_MACFA	Cilia- and flagella-associated protein 68	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	flagellated sperm motility [GO:0030317]		axonemal A tubule inner sheath [GO:0160111]; axoneme [GO:0005930]; cilium [GO:0005929]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005634; GO:0005929; GO:0005930; GO:0030317; GO:0036126; GO:0160111
GN008172	GN008172.1	P22411	37.2	761	822	766	6.30e-158	482	DPP4_PIG	Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]	Sus scrofa (Pig)	endothelial cell migration [GO:0043542]; negative regulation of extracellular matrix disassembly [GO:0010716]; negative regulation of neutrophil chemotaxis [GO:0090024]; positive regulation of cell population proliferation [GO:0008284]; proteolysis [GO:0006508]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; response to hypoxia [GO:0001666]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]	chemorepellent activity [GO:0045499]; dipeptidyl-peptidase activity [GO:0008239]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]; tripeptidyl-peptidase activity [GO:0008240]; virus receptor activity [GO:0001618]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; extracellular region [GO:0005576]; intercellular canaliculus [GO:0046581]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; membrane raft [GO:0045121]	GO:0001618; GO:0001666; GO:0002020; GO:0004252; GO:0005102; GO:0005576; GO:0006508; GO:0008239; GO:0008240; GO:0008284; GO:0009986; GO:0010716; GO:0016324; GO:0030027; GO:0030139; GO:0031258; GO:0031295; GO:0033632; GO:0042110; GO:0042803; GO:0043542; GO:0045121; GO:0045499; GO:0046581; GO:0090024
GN008176	GN008176.1	Q6KEQ9	36.7	316	554	1117	9.81e-48	182	PC11X_PIG	Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X)	Sus scrofa (Pig)	cell adhesion [GO:0007155]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0050839
GN008180	GN008180.1	Q6X862	32.8	787	1163	1347	1.23e-115	394	PC11X_GORGO	Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome)	Gorilla gorilla gorilla (Western lowland gorilla)	cell adhesion [GO:0007155]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0050839
GN008193	GN008193.1	Q9CZJ2	34.6	645	599	685	1.95e-107	341	HS12B_MOUSE	Heat shock 70 kDa protein 12B	Mus musculus (Mouse)	angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]			GO:0001525; GO:0043542
GN008195	GN008195.1	Q924T2	57.3	213	328	291	6.87e-83	255	RT02_MOUSE	Small ribosomal subunit protein uS2m (28S ribosomal protein S2, mitochondrial) (MRP-S2) (S2mt)	Mus musculus (Mouse)	mitochondrial ribosome assembly [GO:0061668]; mitochondrial translation [GO:0032543]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005763; GO:0032543; GO:0061668
GN008196	GN008196.1	Q5DWN0	73.6	53	383	422	5.32e-20	94.4	GFI1_CANLF	Zinc finger protein Gfi-1 (Growth factor independence 1)	Canis lupus familiaris (Dog) (Canis familiaris)	cellular response to lipopolysaccharide [GO:0071222]; DNA damage response [GO:0006974]; negative regulation of neuron projection development [GO:0010977]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme-substrate adaptor activity [GO:0140767]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; transcription repressor complex [GO:0017053]	GO:0000978; GO:0001227; GO:0003700; GO:0006357; GO:0006974; GO:0010977; GO:0016363; GO:0016604; GO:0017053; GO:0034121; GO:0070105; GO:0071222; GO:0140767
GN008197	GN008197.1	B2RUY7	43.0	86	140	222	1.74e-15	73.2	VWC2L_HUMAN	von Willebrand factor C domain-containing protein 2-like (VWC2-like protein) (Brorin-like)	Homo sapiens (Human)	negative regulation of BMP signaling pathway [GO:0030514]		AMPA glutamate receptor complex [GO:0032281]; extracellular region [GO:0005576]; synapse [GO:0045202]	GO:0005576; GO:0030514; GO:0032281; GO:0045202
GN008199	GN008199.1	F1R8P4	37.8	349	335	449	3.41e-71	231	GLRA2_DANRE	Glycine receptor subunit alpha-2	Danio rerio (Zebrafish) (Brachydanio rerio)	chloride transmembrane transport [GO:1902476]	excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; glycine binding [GO:0016594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity [GO:0022824]	glycinergic synapse [GO:0098690]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005231; GO:0005886; GO:0016594; GO:0022824; GO:0045202; GO:0045211; GO:0098690; GO:1902476
GN008201	GN008201.1	Q90640	62.9	383	409	1225	6.64e-145	445	KIF4_CHICK	Chromosome-associated kinesin KIF4 (Chromokinesin)	Gallus gallus (Chicken)	microtubule-based movement [GO:0007018]; mitotic spindle organization [GO:0007052]; spindle elongation [GO:0051231]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	chromosome [GO:0005694]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; nucleus [GO:0005634]	GO:0003777; GO:0005524; GO:0005634; GO:0005694; GO:0005829; GO:0005875; GO:0007018; GO:0007052; GO:0008017; GO:0051231
GN008202	GN008202.1	Q28DG7	44.5	402	407	406	8.95e-106	321	UBAC1_XENTR	Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (E3 ubiquitin-protein ligase subunit KPC2) (Kip1 ubiquitination-promoting complex protein 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	protein maturation [GO:0051604]; protein ubiquitination [GO:0016567]	polyubiquitin modification-dependent protein binding [GO:0031593]; proteasome binding [GO:0070628]	cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005737; GO:0016567; GO:0031593; GO:0051604; GO:0070628
GN008206	GN008206.1	A2RSX4	33.9	218	220	306	5.01e-23	97.4	STPG3_MOUSE	Protein STPG3 (Sperm-tail PG-rich repeat-containing protein 3)	Mus musculus (Mouse)			cytoskeleton [GO:0005856]	GO:0005856
GN008211	GN008211.1	O94760	40.3	233	256	285	5.47e-46	158	DDAH1_HUMAN	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)	Homo sapiens (Human)	arginine metabolic process [GO:0006525]; L-arginine catabolic process [GO:0006527]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of vascular permeability [GO:0043116]; nitric oxide metabolic process [GO:0046209]; positive regulation of angiogenesis [GO:0045766]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of systemic arterial blood pressure [GO:0003073]	amino acid binding [GO:0016597]; dimethylargininase activity [GO:0016403]; nitric-oxide synthase inhibitor activity [GO:0036487]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0003073; GO:0005829; GO:0006525; GO:0006527; GO:0008285; GO:0016403; GO:0016597; GO:0036487; GO:0043116; GO:0045429; GO:0045766; GO:0046209; GO:0070062; GO:1900038
GN008214	GN008214.1	Q5TZ24	37.5	347	466	614	1.68e-78	259	MOXD1_DANRE	DBH-like monooxygenase protein 1 homolog (EC 1.14.17.-)	Danio rerio (Zebrafish) (Brachydanio rerio)		copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]	endoplasmic reticulum membrane [GO:0005789]; secretory granule membrane [GO:0030667]	GO:0004500; GO:0005507; GO:0005789; GO:0016715; GO:0030667
GN008215	GN008215.1	Q9CXI3	32.8	427	399	613	6.61e-72	239	MOXD1_MOUSE	DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X)	Mus musculus (Mouse)		copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]	endoplasmic reticulum membrane [GO:0005789]; secretory granule membrane [GO:0030667]	GO:0004500; GO:0005507; GO:0005789; GO:0016715; GO:0030667
GN008216	GN008216.1	Q5TZ24	43.0	463	1134	614	2.32e-123	395	MOXD1_DANRE	DBH-like monooxygenase protein 1 homolog (EC 1.14.17.-)	Danio rerio (Zebrafish) (Brachydanio rerio)		copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]	endoplasmic reticulum membrane [GO:0005789]; secretory granule membrane [GO:0030667]	GO:0004500; GO:0005507; GO:0005789; GO:0016715; GO:0030667
GN008217	GN008217.1	Q5TZ24	40.4	455	1042	614	8.06e-113	365	MOXD1_DANRE	DBH-like monooxygenase protein 1 homolog (EC 1.14.17.-)	Danio rerio (Zebrafish) (Brachydanio rerio)		copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]	endoplasmic reticulum membrane [GO:0005789]; secretory granule membrane [GO:0030667]	GO:0004500; GO:0005507; GO:0005789; GO:0016715; GO:0030667
GN008218	GN008218.1	Q98ST7	41.0	161	183	614	2.04e-32	125	MOXD1_CHICK	DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X)	Gallus gallus (Chicken)		copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]	endoplasmic reticulum membrane [GO:0005789]; secretory granule membrane [GO:0030667]	GO:0004500; GO:0005507; GO:0005789; GO:0016715; GO:0030667
GN008220	GN008220.1	Q0GC71	30.3	287	341	784	2.33e-35	139	TLR2_CAPHI	Toll-like receptor 2 (CD antigen CD282)	Capra hircus (Goat)	cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; immune response [GO:0006955]; inflammatory response [GO:0006954]; toll-like receptor signaling pathway [GO:0002224]	transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0002224; GO:0004888; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0016020; GO:0030670; GO:0042497; GO:0043235; GO:0045121; GO:0071726; GO:0071727
GN008221	GN008221.1	O02467	52.4	311	354	320	2.14e-103	310	ASPG_SPOFR	N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (AGA) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain]	Spodoptera frugiperda (Fall armyworm)		N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity [GO:0003948]	lysosome [GO:0005764]	GO:0003948; GO:0005764
GN008222	GN008222.1	P53767	29.7	1156	1411	1336	4.32e-133	447	VGFR1_RAT	Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT)	Rattus norvegicus (Rat)	angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; branching involved in blood vessel morphogenesis [GO:0001569]; cell migration [GO:0016477]; cellular response to hypoxia [GO:0071456]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; embryonic morphogenesis [GO:0048598]; female pregnancy [GO:0007565]; hyaloid vascular plexus regression [GO:1990384]; intracellular receptor signaling pathway [GO:0030522]; liver regeneration [GO:0097421]; monocyte chemotaxis [GO:0002548]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; negative regulation of vascular endothelial growth factor production [GO:1904046]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of vascular permeability [GO:0043117]; post-embryonic camera-type eye morphogenesis [GO:0048597]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of smooth muscle contraction [GO:0006940]; response to activity [GO:0014823]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-1 signaling pathway [GO:0036323]	ATP binding [GO:0005524]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; placental growth factor receptor activity [GO:0036332]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; vascular endothelial growth factor receptor activity [GO:0005021]	endosome [GO:0005768]; extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001525; GO:0001569; GO:0001666; GO:0002040; GO:0002548; GO:0004713; GO:0004714; GO:0005021; GO:0005524; GO:0005576; GO:0005634; GO:0005768; GO:0005886; GO:0006468; GO:0006940; GO:0007565; GO:0008284; GO:0014823; GO:0016477; GO:0018108; GO:0019838; GO:0030335; GO:0030522; GO:0032355; GO:0035924; GO:0036323; GO:0036332; GO:0042802; GO:0043117; GO:0043235; GO:0043406; GO:0043410; GO:0045471; GO:0045766; GO:0046777; GO:0048010; GO:0048514; GO:0048597; GO:0048598; GO:0048661; GO:0051897; GO:0060252; GO:0071456; GO:0097421; GO:1901534; GO:1903671; GO:1904046; GO:1905563; GO:1990384
GN008223	GN008223.1	Q9CR35	30.8	279	315	263	5.02e-36	133	CTRB1_MOUSE	Chymotrypsinogen B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C]	Mus musculus (Mouse)	positive regulation of apoptotic process [GO:0043065]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; response to cytokine [GO:0034097]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular region [GO:0005576]	GO:0004252; GO:0005576; GO:0006508; GO:0008233; GO:0008236; GO:0030163; GO:0034097; GO:0043065
GN008224	GN008224.1	P53370	51.1	262	290	316	2.79e-91	276	NUDT6_HUMAN	Nudix hydrolase 6 (Antisense basic fibroblast growth factor) (FAD diphosphatase NUDT6) (EC 3.6.1.18) (NADH pyrophosphatase NUDT6) (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 6) (Nudix motif 6) (Protein GFG)	Homo sapiens (Human)	negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]	FAD diphosphatase activity [GO:0047884]; NADH pyrophosphatase activity [GO:0035529]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0008285; GO:0035529; GO:0045786; GO:0047884
GN008226	GN008226.1	Q9SVG0	31.6	456	484	436	5.22e-47	171	AVT3C_ARATH	Amino acid transporter AVT3C (AtAvt3C) (Aromatic and neutral amino acid transporter-like protein 2)	Arabidopsis thaliana (Mouse-ear cress)	amino acid transmembrane transport [GO:0003333]; neutral amino acid transport [GO:0015804]	L-amino acid transmembrane transporter activity [GO:0015179]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]	GO:0003333; GO:0005774; GO:0005886; GO:0015175; GO:0015179; GO:0015804
GN008227	GN008227.1	P80944	33.7	101	836	148	3.70e-14	73.9	ZFX_PIG	Zinc finger X-chromosomal protein	Sus scrofa (Pig)		DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]	nucleus [GO:0005634]	GO:0001228; GO:0005634
GN008228	GN008228.1	P98072	28.6	423	799	1035	4.42e-40	163	ENTK_BOVIN	Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain]	Bos taurus (Bovine)	protein digestion [GO:0044256]; protein processing [GO:0016485]; trypsinogen activation [GO:0032023]	serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	membrane [GO:0016020]	GO:0004252; GO:0008236; GO:0016020; GO:0016485; GO:0032023; GO:0044256
GN008229	GN008229.1	P15043	43.7	71	118	609	5.76e-10	58.5	RECQ_ECOLI	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Escherichia coli (strain K12)	DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; G-quadruplex unwinding activity [GO:0160225]; single-stranded DNA helicase activity [GO:0017116]; transition metal ion binding [GO:0046914]; zinc ion binding [GO:0008270]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]; single-stranded DNA-dependent ATP-dependent DNA helicase complex [GO:0017117]	GO:0003677; GO:0003678; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0006974; GO:0008094; GO:0008270; GO:0009432; GO:0016887; GO:0017116; GO:0017117; GO:0030894; GO:0043138; GO:0043590; GO:0046914; GO:0160225
GN008230	GN008230.1	P15043	43.7	71	189	609	4.06e-09	58.5	RECQ_ECOLI	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Escherichia coli (strain K12)	DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; G-quadruplex unwinding activity [GO:0160225]; single-stranded DNA helicase activity [GO:0017116]; transition metal ion binding [GO:0046914]; zinc ion binding [GO:0008270]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]; single-stranded DNA-dependent ATP-dependent DNA helicase complex [GO:0017117]	GO:0003677; GO:0003678; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0006974; GO:0008094; GO:0008270; GO:0009432; GO:0016887; GO:0017116; GO:0017117; GO:0030894; GO:0043138; GO:0043590; GO:0046914; GO:0160225
GN008233	GN008233.1	P22897	29.9	1071	1560	1456	1.92e-150	501	MRC1_HUMAN	Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206)	Homo sapiens (Human)	receptor-mediated endocytosis [GO:0006898]	cargo receptor activity [GO:0038024]; D-mannose binding [GO:0005537]; transmembrane signaling receptor activity [GO:0004888]	cell surface [GO:0009986]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	GO:0004888; GO:0005537; GO:0005886; GO:0006898; GO:0009986; GO:0010008; GO:0038024
GN008235	GN008235.1	Q8IV35	24.0	846	1104	1049	7.98e-58	221	CF337_HUMAN	Cilia- and flagella-associated protein 337 (WD repeat-containing protein 49)	Homo sapiens (Human)		calcium ion binding [GO:0005509]	cilium [GO:0005929]	GO:0005509; GO:0005929
GN008237	GN008237.1	Q8LFJ5	54.5	110	135	124	8.87e-34	117	T112A_ARATH	Multifunctional methyltransferase subunit TRM112 homolog A (Multifunctional methyltransferase subunit TRM112-like protein At1g22270) (Protein SMALL ORGAN 2) (tRNA methyltransferase 112 homolog A) (AtTRM112a)	Arabidopsis thaliana (Mouse-ear cress)	maturation of LSU-rRNA [GO:0000470]; maturation of SSU-rRNA [GO:0030490]; organ growth [GO:0035265]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]	methyltransferase regulator activity [GO:0141107]; protein heterodimerization activity [GO:0046982]; tRNA methyltransferase activator activity [GO:0141106]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; tRNA (m2G10) methyltransferase complex [GO:0043528]	GO:0000470; GO:0005634; GO:0005737; GO:0030490; GO:0035265; GO:0042127; GO:0043528; GO:0046982; GO:0051726; GO:0141106; GO:0141107
GN008238	GN008238.1	P38542	66.3	205	212	215	7.62e-101	293	RAN_BRUMA	GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4)	Brugia malayi (Filarial nematode worm)	embryo development ending in birth or egg hatching [GO:0009792]; oogenesis [GO:0048477]; protein import into nucleus [GO:0006606]; ribosomal subunit export from nucleus [GO:0000054]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000054; GO:0003924; GO:0005525; GO:0005634; GO:0005737; GO:0006606; GO:0009792; GO:0048477
GN008240	GN008240.1	Q1RMP0	55.0	109	115	123	7.21e-42	137	RPA12_BOVIN	DNA-directed RNA polymerase I subunit RPA12 (DNA-directed RNA polymerase I subunit H)	Bos taurus (Bovine)	termination of RNA polymerase I transcription [GO:0006363]	DNA-directed RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]	GO:0003676; GO:0003899; GO:0005654; GO:0005736; GO:0006363; GO:0008270
GN008242	GN008242.1	Q05A80	32.4	111	120	1031	4.72e-10	58.9	CAPR2_MOUSE	Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (RNA granule protein 140)	Mus musculus (Mouse)	negative regulation of cell growth [GO:0030308]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of transcription by RNA polymerase II [GO:0045944]	signaling receptor binding [GO:0005102]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0005102; GO:0005654; GO:0005737; GO:0005739; GO:0005813; GO:0005829; GO:0005886; GO:0030308; GO:0043235; GO:0045944; GO:0050775; GO:0061003; GO:0090263
GN008247	GN008247.1	Q08DA0	46.8	498	795	701	3.14e-120	381	RABL6_BOVIN	Rab-like protein 6 (EC 3.6.5.2) (GTP-binding protein Parf) (Rab-like protein 1) (RBEL1)	Bos taurus (Bovine)		G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003924; GO:0003925; GO:0005525; GO:0005634; GO:0005737; GO:0005829
GN008248	GN008248.1	A7MBH5	35.3	552	769	621	1.38e-82	278	ODAD3_BOVIN	Outer dynein arm-docking complex subunit 3 (Coiled-coil domain-containing protein 151)	Bos taurus (Bovine)	cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]; regulation of cilium assembly [GO:1902017]		axoneme [GO:0005930]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary rootlet [GO:0035253]; ciliary tip [GO:0097542]; cilium [GO:0005929]; outer dynein arm docking complex [GO:0120228]	GO:0003341; GO:0005814; GO:0005929; GO:0005930; GO:0035253; GO:0036064; GO:0036158; GO:0097542; GO:0120228; GO:1902017
GN008249	GN008249.1	Q5ZMV3	70.6	136	170	176	7.06e-63	194	NC2B_CHICK	Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein)	Gallus gallus (Chicken)	negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of embryonic development [GO:0045995]; RNA polymerase II preinitiation complex assembly [GO:0051123]	protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]	ATAC complex [GO:0140672]; negative cofactor 2 complex [GO:0017054]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0005654; GO:0016251; GO:0017025; GO:0017054; GO:0045995; GO:0046982; GO:0051123; GO:0051302; GO:0051726; GO:0090575; GO:0140672
GN008251	GN008251.1	Q708S8	28.7	181	185	557	5.21e-13	69.7	ASI1B_DANRE	Acid-sensing ion channel 1B (ASIC1-B) (Acid-sensing ion channel 1.1-B) (Amiloride-sensitive cation channel 2-A, neuronal-B) (ZASIC1.1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to pH [GO:0071467]; sodium ion transmembrane transport [GO:0035725]	ligand-gated sodium channel activity [GO:0015280]; pH-gated monoatomic ion channel activity [GO:0160128]; pH-gated sodium channel activity [GO:0160125]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0005886; GO:0015280; GO:0030425; GO:0035725; GO:0045211; GO:0071467; GO:0160125; GO:0160128
GN008252	GN008252.1	Q708S5	29.2	397	418	533	4.49e-41	155	ASIC2_DANRE	Acid-sensing ion channel 2 (ASIC2) (ZASIC2)	Danio rerio (Zebrafish) (Brachydanio rerio)	response to steroid hormone [GO:0048545]; sodium ion transmembrane transport [GO:0035725]	pH-gated sodium channel activity [GO:0160125]	plasma membrane [GO:0005886]	GO:0005886; GO:0035725; GO:0048545; GO:0160125
GN008256	GN008256.1	Q96LT4	35.9	376	582	415	1.02e-72	241	SAMD8_HUMAN	Sphingomyelin synthase-related protein 1 (SMSr) (EC 2.7.8.-) (Ceramide phosphoethanolamine synthase) (CPE synthase) (Phosphatidylethanolamine Phospholipase C) (PE-PLC) (EC 3.1.4.62) (Sterile alpha motif domain-containing protein 8) (SAM domain-containing protein 8)	Homo sapiens (Human)	ceramide biosynthetic process [GO:0046513]; regulation of ceramide biosynthetic process [GO:2000303]; sphingomyelin biosynthetic process [GO:0006686]	ceramide cholinephosphotransferase activity [GO:0047493]; ceramide phosphoethanolamine synthase activity [GO:0002950]; sphingomyelin synthase activity [GO:0033188]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0000139; GO:0002950; GO:0005783; GO:0005789; GO:0005886; GO:0006686; GO:0016020; GO:0033188; GO:0046513; GO:0047493; GO:2000303
GN008257	GN008257.1	Q7ZUC7	44.2	283	309	377	5.13e-79	248	PGES2_DANRE	Prostaglandin E synthase 2 (EC 5.3.99.3) (Microsomal prostaglandin E synthase 2) (mPGES-2)	Danio rerio (Zebrafish) (Brachydanio rerio)	prostaglandin biosynthetic process [GO:0001516]	12-hydroxyheptadecatrienoic acid synthase activity [GO:0036134]; glutathione binding [GO:0043295]; heme binding [GO:0020037]; lyase activity [GO:0016829]; prostaglandin-E synthase activity [GO:0050220]	Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]	GO:0000139; GO:0001516; GO:0005739; GO:0016829; GO:0020037; GO:0036134; GO:0043295; GO:0050220
GN008259	GN008259.1	Q6IR37	31.6	212	218	284	1.65e-24	100	ZDH24_MOUSE	Probable palmitoyltransferase ZDHHC24 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 24)	Mus musculus (Mouse)	protein targeting to membrane [GO:0006612]	protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	GO:0005783; GO:0006612; GO:0016020; GO:0019706
GN008261	GN008261.1	Q7Z591	29.5	254	1915	1439	2.47e-11	73.2	AKNA_HUMAN	Microtubule organization protein AKNA (AT-hook-containing transcription factor)	Homo sapiens (Human)	delamination [GO:0060232]; epithelial to mesenchymal transition [GO:0001837]; neuroblast delamination [GO:0060234]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of inflammatory response [GO:0050727]		centriole [GO:0005814]; centrosome [GO:0005813]; fibrillar center [GO:0001650]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001650; GO:0001837; GO:0005634; GO:0005654; GO:0005813; GO:0005814; GO:0005874; GO:0016020; GO:0021849; GO:0045944; GO:0050727; GO:0060232; GO:0060234
GN008262	GN008262.1	Q9UGQ2	40.4	136	175	172	6.36e-31	113	FLOWR_HUMAN	Calcium channel flower homolog (Calcium channel flower domain-containing protein 1)	Homo sapiens (Human)	vesicle-mediated transport [GO:0016192]		early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]	GO:0001772; GO:0005769; GO:0005789; GO:0005794; GO:0005886; GO:0008021; GO:0016192; GO:0031982; GO:0055037
GN008265	GN008265.1	Q27746	53.4	691	966	1612	2.22e-238	721	DNMT1_PARLI	DNA (cytosine-5)-methyltransferase PliMCI (EC 2.1.1.37) (DNA methyltransferase PliMCI) (DNA MTase PliMCI) (M.PliMCI) (Dnmt1) (MCMT)	Paracentrotus lividus (Common sea urchin)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]	chromatin binding [GO:0003682]; DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA binding [GO:0003677]; histone H3K14ub reader activity [GO:0140258]; histone H3K18ub reader activity [GO:0140254]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; heterochromatin [GO:0000792]; nucleus [GO:0005634]	GO:0000792; GO:0003677; GO:0003682; GO:0003886; GO:0005634; GO:0005694; GO:0008270; GO:0044027; GO:0140254; GO:0140258; GO:0141119
GN008266	GN008266.1	D9HP19	33.3	105	108	167	8.07e-13	63.9	CNR3_MAIZE	Cell number regulator 3 (ZmCNR03)	Zea mays (Maize)			membrane [GO:0016020]	GO:0016020
GN008272	GN008272.1	Q99PP7	24.9	281	600	1142	7.19e-22	104	TRI33_MOUSE	E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)	Mus musculus (Mouse)	gene expression [GO:0010467]; negative regulation of BMP signaling pathway [GO:0030514]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	co-SMAD binding [GO:0070410]; promoter-specific chromatin binding [GO:1990841]; R-SMAD binding [GO:0070412]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0008270; GO:0010467; GO:0016567; GO:0017015; GO:0030514; GO:0061630; GO:0070410; GO:0070412; GO:1990841
GN008274	GN008274.1	P23128	80.4	403	446	459	4.64e-242	671	DDX6_DROME	ATP-dependent RNA helicase me31b (EC 3.6.4.13) (Maternal expression at 31B)	Drosophila melanogaster (Fruit fly)	deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; follicle cell of egg chamber development [GO:0030707]; habituation [GO:0046959]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; P-body assembly [GO:0033962]; pole cell formation [GO:0007279]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of post-transcriptional gene silencing [GO:0060148]; regulation of defense response to virus [GO:0050688]; regulation of neuron projection arborization [GO:0150011]; regulation of olfactory learning [GO:0090328]; stress granule assembly [GO:0034063]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; mRNA regulatory element binding translation repressor activity [GO:0000900]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; endoplasmic reticulum [GO:0005783]; neuronal cell body [GO:0043025]; neuronal ribonucleoprotein granule [GO:0071598]; P granule [GO:0043186]; P-body [GO:0000932]; postsynapse [GO:0098794]; sensory dendrite [GO:0071683]	GO:0000288; GO:0000290; GO:0000900; GO:0000932; GO:0003723; GO:0003724; GO:0005524; GO:0005737; GO:0005783; GO:0007279; GO:0010494; GO:0016887; GO:0017148; GO:0030707; GO:0031087; GO:0033962; GO:0034063; GO:0035195; GO:0035278; GO:0036464; GO:0043025; GO:0043186; GO:0046959; GO:0050688; GO:0060148; GO:0061014; GO:0071598; GO:0071683; GO:0090328; GO:0098794; GO:0150011; GO:2000766
GN008275	GN008275.1	A8J4S9	45.5	475	682	626	3.22e-155	465	TREA_APIME	Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)	Apis mellifera (Honeybee)	trehalose catabolic process [GO:0005993]	alpha,alpha-trehalase activity [GO:0004555]	membrane [GO:0016020]	GO:0004555; GO:0005993; GO:0016020
GN008282	GN008282.1	Q9FT72	27.3	454	513	713	7.35e-34	139	RQL3_ARATH	ATP-dependent DNA helicase Q-like 3 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ3) (RecQ-like protein 3) (AtRecQ3) (AtRecQl3)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004386; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006310; GO:0009378; GO:0016887; GO:0043138; GO:1990814
GN008283	GN008283.1	Q15291	66.1	481	517	538	1.18e-225	635	RBBP5_HUMAN	Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)	Homo sapiens (Human)	DNA damage response [GO:0006974]; response to estrogen [GO:0043627]; transcription initiation-coupled chromatin remodeling [GO:0045815]	histone binding [GO:0042393]; transcription cis-regulatory region binding [GO:0000976]	histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]	GO:0000976; GO:0005634; GO:0005654; GO:0005730; GO:0006974; GO:0035097; GO:0042393; GO:0043627; GO:0044665; GO:0044666; GO:0045815; GO:0048188; GO:0071339
GN008284	GN008284.1	Q8N7N5	55.5	461	756	591	1.05e-172	511	DCAF8_MOUSE	DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)	Mus musculus (Mouse)	myotube cell development [GO:0014904]; protein ubiquitination [GO:0016567]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0007283; GO:0007338; GO:0014904; GO:0016567; GO:0080008
GN008285	GN008285.1	P16386	37.7	810	841	756	3.75e-159	485	LIPS_BOVIN	Hormone-sensitive lipase (HSL) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (EC 3.1.1.23) (Retinyl ester hydrolase) (REH)	Bos taurus (Bovine)	cholesterol metabolic process [GO:0008203]; diacylglycerol catabolic process [GO:0046340]; ether lipid metabolic process [GO:0046485]; lipid catabolic process [GO:0016042]; termination of RNA polymerase I transcription [GO:0006363]; transcription initiation at RNA polymerase I promoter [GO:0006361]; triglyceride catabolic process [GO:0019433]	acetylalkylglycerol acetylhydrolase activity [GO:0047378]; all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; diacylglycerol lipase activity [GO:0120516]; monoacylglycerol lipase activity [GO:0047372]; retinyl-palmitate esterase activity [GO:0050253]; rRNA primary transcript binding [GO:0042134]; sterol ester esterase activity [GO:0004771]; triacylglycerol lipase activity [GO:0004806]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0004771; GO:0004806; GO:0005634; GO:0005737; GO:0005739; GO:0005811; GO:0005829; GO:0005886; GO:0005901; GO:0006361; GO:0006363; GO:0008203; GO:0016020; GO:0016042; GO:0019433; GO:0042134; GO:0046340; GO:0046485; GO:0047372; GO:0047376; GO:0047378; GO:0050253; GO:0120516
GN008293	GN008293.1	Q8K2J9	33.3	450	459	539	2.07e-71	238	BTBD6_MOUSE	BTB/POZ domain-containing protein 6	Mus musculus (Mouse)	neurogenesis [GO:0022008]		cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0022008
GN008294	GN008294.1	Q58PK5	29.1	206	232	802	1.53e-13	72.8	ILE22_BOMVA	Peptidylaminoacyl-L/D-isomerase polyprotein 2 (EC 5.1.1.21) (Frog skin isomerase)	Bombina variegata (Yellow-bellied toad)				
GN008301	GN008301.1	Q9BG99	41.0	161	537	315	6.46e-27	114	TREX1_BOVIN	Three-prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1)	Bos taurus (Bovine)	DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; negative regulation of innate immune response [GO:0045824]	3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; DNA binding [GO:0003677]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0005789; GO:0005829; GO:0006259; GO:0006281; GO:0008296; GO:0008311; GO:0008408; GO:0045824
GN008303	GN008303.1	Q08257	49.6	228	236	329	5.29e-69	218	QOR_HUMAN	Zeta-crystallin (NADPH:quinone reductase) (Quinone oxidoreductase) (EC 1.6.5.5)	Homo sapiens (Human)	mRNA stabilization [GO:0048255]; protein homotetramerization [GO:0051289]; visual perception [GO:0007601]; xenobiotic catabolic process [GO:0042178]	identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; NADPH binding [GO:0070402]; quinone reductase (NADPH) activity [GO:0003960]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	GO:0003730; GO:0003960; GO:0005739; GO:0005829; GO:0007601; GO:0008270; GO:0042178; GO:0042802; GO:0048255; GO:0051289; GO:0070062; GO:0070402
GN008307	GN008307.1	Q96RW7	35.5	645	682	5635	6.92e-85	296	HMCN1_HUMAN	Hemicentin-1 (Fibulin-6) (FIBL-6)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion mediator activity [GO:0098631]; extracellular matrix structural constituent [GO:0005201]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; muscle tendon junction [GO:0005927]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005886; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0030036; GO:0031012; GO:0032154; GO:0070062; GO:0070161; GO:0071711; GO:0098631; GO:0140144
GN008308	GN008308.1	P80025	36.2	207	208	712	5.77e-25	105	PERL_BOVIN	Lactoperoxidase (LPO) (EC 1.11.1.7)	Bos taurus (Bovine)	antibacterial humoral response [GO:0019731]; defense response to bacterium [GO:0042742]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979]	calcium ion binding [GO:0005509]; heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; peroxidase activity [GO:0004601]; thiocyanate peroxidase activity [GO:0036393]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]	GO:0001580; GO:0004601; GO:0005509; GO:0005576; GO:0005737; GO:0006979; GO:0016323; GO:0019731; GO:0020037; GO:0036393; GO:0042742; GO:0042744; GO:0140825
GN008309	GN008309.1	P11247	35.3	573	552	718	1.17e-85	283	PERM_MOUSE	Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase light chain; Myeloperoxidase heavy chain]	Mus musculus (Mouse)	defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; hydrogen peroxide catabolic process [GO:0042744]; hypochlorous acid biosynthetic process [GO:0002149]; low-density lipoprotein particle remodeling [GO:0034374]; neutrophil extracellular trap formation [GO:0140645]; neutrophil-mediated killing of bacterium [GO:0070944]; neutrophil-mediated killing of fungus [GO:0070947]; neutrophil-mediated killing of symbiont cell [GO:0070943]; nucleosome disassembly [GO:0006337]; positive regulation of cholesterol import [GO:1904109]; removal of superoxide radicals [GO:0019430]; respiratory burst involved in defense response [GO:0002679]; response to food [GO:0032094]; response to gold nanoparticle [GO:1990268]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to oxidative stress [GO:0006979]; response to yeast [GO:0001878]	heme binding [GO:0020037]; heparin binding [GO:0008201]; nucleosome binding [GO:0031491]; peroxidase activity [GO:0004601]; protein-containing complex destabilizing activity [GO:0140776]; thiocyanate peroxidase activity [GO:0036393]	azurophil granule [GO:0042582]; chromosome [GO:0005694]; cytolytic granule [GO:0044194]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; neutrophil extracellular trap [GO:0140644]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; secretory granule [GO:0030141]	GO:0001878; GO:0002149; GO:0002679; GO:0004601; GO:0005576; GO:0005634; GO:0005654; GO:0005694; GO:0005739; GO:0006337; GO:0006979; GO:0008201; GO:0009612; GO:0019430; GO:0020037; GO:0030141; GO:0031491; GO:0032094; GO:0032496; GO:0034374; GO:0036393; GO:0042582; GO:0042742; GO:0042744; GO:0044194; GO:0045335; GO:0050832; GO:0070943; GO:0070944; GO:0070947; GO:0140644; GO:0140645; GO:0140776; GO:1904109; GO:1990268
GN008310	GN008310.1	H2A0M7	33.3	219	208	793	1.69e-29	118	PLSP_PINMG	Peroxidase-like protein	Margaritifera margaritifera (Freshwater pearl mussel)	response to oxidative stress [GO:0006979]	heme binding [GO:0020037]; peroxidase activity [GO:0004601]	extracellular region [GO:0005576]	GO:0004601; GO:0005576; GO:0006979; GO:0020037
GN008313	GN008313.1	H2A0M7	35.6	312	317	793	1.81e-54	192	PLSP_PINMG	Peroxidase-like protein	Margaritifera margaritifera (Freshwater pearl mussel)	response to oxidative stress [GO:0006979]	heme binding [GO:0020037]; peroxidase activity [GO:0004601]	extracellular region [GO:0005576]	GO:0004601; GO:0005576; GO:0006979; GO:0020037
GN008315	GN008315.1	Q8K0U4	30.8	630	657	675	2.83e-91	300	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN008316	GN008316.1	Q09225	27.5	684	734	822	6.57e-74	259	NRF6_CAEEL	Nose resistant to fluoxetine protein 6 (Protein nrf-6)	Caenorhabditis elegans		acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]	membrane [GO:0016020]	GO:0016020; GO:0016747
GN008317	GN008317.1	Q8BML2	27.9	251	279	685	3.61e-22	99.4	OACYL_MOUSE	O-acyltransferase like protein (Protein oacyl)	Mus musculus (Mouse)		acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]	membrane [GO:0016020]	GO:0016020; GO:0016747
GN008319	GN008319.1	Q09225	28.9	678	705	822	1.61e-81	279	NRF6_CAEEL	Nose resistant to fluoxetine protein 6 (Protein nrf-6)	Caenorhabditis elegans		acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]	membrane [GO:0016020]	GO:0016020; GO:0016747
GN008320	GN008320.1	Q8K0U4	30.9	640	591	675	1.42e-90	296	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN008321	GN008321.1	Q8BR86	32.3	517	668	778	4.24e-80	273	KIRR3_MOUSE	Kin of IRRE-like protein 3 (Kin of irregular chiasm-like protein 3) (Nephrin-like protein 2) (mKirre) [Cleaved into: Processed kin of IRRE-like protein 3]	Mus musculus (Mouse)	cell-cell adhesion [GO:0098609]; glomerulus morphogenesis [GO:0072102]; hemopoiesis [GO:0030097]; hippocampus development [GO:0021766]; homophilic cell-cell adhesion [GO:0007156]; inter-male aggressive behavior [GO:0002121]; neuron migration [GO:0001764]; neuron projection morphogenesis [GO:0048812]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; synapse assembly [GO:0007416]	cell adhesion molecule binding [GO:0050839]; PDZ domain binding [GO:0030165]	axon [GO:0030424]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GO:0001764; GO:0002121; GO:0005576; GO:0005886; GO:0005911; GO:0007156; GO:0007416; GO:0008021; GO:0016020; GO:0021740; GO:0021766; GO:0030097; GO:0030165; GO:0030424; GO:0030425; GO:0043198; GO:0048812; GO:0050839; GO:0072102; GO:0098609
GN008322	GN008322.1	Q6DJ83	27.8	248	516	433	3.37e-12	72.0	CADM2_XENTR	Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	homophilic cell-cell adhesion [GO:0007156]		neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GO:0005886; GO:0007156; GO:0032809
GN008324	GN008324.1	Q9V477	35.1	188	532	1346	1.90e-32	136	TOLL8_DROME	Toll-like receptor Tollo (Toll-like receptor 8)	Drosophila melanogaster (Fruit fly)	axis elongation [GO:0003401]; convergent extension [GO:0060026]; peripheral nervous system neuron development [GO:0048935]; regulation of glycoprotein biosynthetic process [GO:0010559]; signal transduction [GO:0007165]	receptor ligand activity [GO:0048018]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0003401; GO:0005886; GO:0007165; GO:0010559; GO:0016324; GO:0048018; GO:0048935; GO:0060026
GN008327	GN008327.1	Q8BH75	65.7	315	315	317	2.52e-159	450	RNF41_MOUSE	E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)	Mus musculus (Mouse)	extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mitophagy [GO:1901525]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of lymphocyte differentiation [GO:0045619]; regulation of MAPK cascade [GO:0043408]; regulation of myeloid cell differentiation [GO:0045637]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of reactive oxygen species metabolic process [GO:2000377]	erythropoietin receptor binding [GO:0005128]; identical protein binding [GO:0042802]; interleukin-3 receptor binding [GO:0005135]; protein domain specific binding [GO:0019904]; receptor tyrosine kinase binding [GO:0030971]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	endoplasmic reticulum tubular network [GO:0071782]; perinuclear region of cytoplasm [GO:0048471]	GO:0000209; GO:0004842; GO:0005128; GO:0005135; GO:0008270; GO:0008285; GO:0010498; GO:0019904; GO:0030336; GO:0030971; GO:0031267; GO:0042802; GO:0043408; GO:0045619; GO:0045637; GO:0045732; GO:0048471; GO:0051865; GO:0051896; GO:0061630; GO:0071782; GO:0097191; GO:1901525; GO:2000377; GO:2000379
GN008329	GN008329.1	Q8TBB0	35.0	117	168	222	2.71e-16	76.3	THAP6_HUMAN	THAP domain-containing protein 6	Homo sapiens (Human)			microtubule cytoskeleton [GO:0015630]	GO:0015630
GN008334	GN008334.1	B3RTL9	87.3	166	170	168	6.79e-110	313	UFC1_TRIAD	Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1)	Trichoplax adhaerens (Trichoplax reptans)	protein ufmylation [GO:0071569]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]	UFM1 conjugating enzyme activity [GO:0061657]; UFM1 transferase activity [GO:0071568]	cytoplasm [GO:0005737]	GO:0005737; GO:0034976; GO:0061657; GO:0061709; GO:0071568; GO:0071569
GN008338	GN008338.1	Q09324	35.1	382	518	428	2.27e-67	226	GCNT1_MOUSE	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GlcNAcT) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT) (Leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GnT-L)	Mus musculus (Mouse)	cell adhesion molecule production [GO:0060352]; glycoprotein biosynthetic process [GO:0009101]; kidney morphogenesis [GO:0060993]; leukocyte tethering or rolling [GO:0050901]; positive regulation of leukocyte tethering or rolling [GO:1903238]; protein O-linked glycosylation via N-acetyl-galactosamine [GO:0016266]; tissue morphogenesis [GO:0048729]	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]	extracellular region [GO:0005576]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; nuclear speck [GO:0016607]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0003829; GO:0005576; GO:0005802; GO:0009101; GO:0016266; GO:0016607; GO:0031985; GO:0048729; GO:0050901; GO:0060352; GO:0060993; GO:1903238
GN008340	GN008340.1	P51687	50.8	516	576	545	2.58e-174	507	SUOX_HUMAN	Sulfite oxidase, mitochondrial (HSO) (EC 1.8.3.1) (Nitrite reductase, mitochondrial) (EC 1.7.-.-)	Homo sapiens (Human)	sulfur compound metabolic process [GO:0006790]	heme binding [GO:0020037]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; nitrite reductase activity [GO:0098809]; sulfite oxidase activity [GO:0008482]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0005758; GO:0005759; GO:0006790; GO:0008482; GO:0020037; GO:0030151; GO:0043546; GO:0098809
GN008347	GN008347.1	Q8VCK5	87.8	329	616	604	1.20e-205	591	KLH20_MOUSE	Kelch-like protein 20 (Kelch-like ECT2-interacting protein)	Mus musculus (Mouse)	Golgi to endosome transport [GO:0006895]; negative regulation of apoptotic process [GO:0043066]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K33-linked ubiquitination [GO:1990390]; protein ubiquitination [GO:0016567]	type II interferon binding [GO:0019964]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]	axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; trans-Golgi network [GO:0005802]	GO:0004842; GO:0005737; GO:0005794; GO:0005802; GO:0005829; GO:0006895; GO:0016567; GO:0016605; GO:0019964; GO:0030424; GO:0030425; GO:0031463; GO:0043066; GO:0043161; GO:0048471; GO:1990390; GO:1990756
GN008348	GN008348.1	Q5TZF3	35.7	207	306	266	5.16e-33	125	ANR45_HUMAN	Ankyrin repeat domain-containing protein 45	Homo sapiens (Human)	cell population proliferation [GO:0008283]		cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Flemming body [GO:0090543]; midbody [GO:0030496]	GO:0005737; GO:0005829; GO:0008283; GO:0030496; GO:0032154; GO:0090543
GN008349	GN008349.1	Q6P4H8	53.4	174	206	233	3.08e-64	201	ACKMT_HUMAN	ATP synthase subunit C lysine N-methyltransferase (EC 2.1.1.-) (Protein N-lysine methyltransferase FAM173B) (hFAM173B)	Homo sapiens (Human)	peptidyl-lysine trimethylation [GO:0018023]; positive regulation of proton-transporting ATP synthase activity, rotational mechanism [GO:1905273]; positive regulation of sensory perception of pain [GO:1904058]; regulation of mitochondrial ATP synthesis coupled proton transport [GO:1905706]	protein-lysine N-methyltransferase activity [GO:0016279]	mitochondrial crista [GO:0030061]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	GO:0005739; GO:0016279; GO:0018023; GO:0030061; GO:0031966; GO:1904058; GO:1905273; GO:1905706
GN008350	GN008350.1	P41105	59.8	127	135	137	9.34e-46	148	RL28_MOUSE	Large ribosomal subunit protein eL28 (60S ribosomal protein L28)	Mus musculus (Mouse)	cytoplasmic translation [GO:0002181]; negative regulation of myoblast fusion [GO:1901740]; spermatogenesis [GO:0007283]; striated muscle contraction [GO:0006941]; translation at postsynapse [GO:0140242]; translation at presynapse [GO:0140236]	structural constituent of ribosome [GO:0003735]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; postsynapse [GO:0098794]; presynapse [GO:0098793]; ribosome [GO:0005840]; synapse [GO:0045202]	GO:0002181; GO:0003735; GO:0005737; GO:0005783; GO:0005829; GO:0005840; GO:0006941; GO:0007283; GO:0022625; GO:0022626; GO:0030425; GO:0036464; GO:0044297; GO:0045202; GO:0098793; GO:0098794; GO:0140236; GO:0140242; GO:1901740
GN008356	GN008356.1	Q14517	35.3	3447	3425	4588	0.0	1822	FAT1_HUMAN	Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]	Homo sapiens (Human)	anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; homophilic cell-cell adhesion [GO:0007156]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0005509; GO:0005634; GO:0005829; GO:0005886; GO:0005911; GO:0005912; GO:0005925; GO:0007155; GO:0007156; GO:0007267; GO:0009653; GO:0016477; GO:0044331; GO:0048471; GO:0070062; GO:1904385; GO:1904754
GN008357	GN008357.1	P02350	80.6	263	265	246	1.49e-142	402	RS3A_XENLA	Small ribosomal subunit protein uS3A (EC 4.2.99.18) (40S ribosomal protein S3) (S1A)	Xenopus laevis (African clawed frog)	positive regulation of apoptotic signaling pathway [GO:2001235]; translation [GO:0006412]	class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic small ribosomal subunit [GO:0022627]; mitochondrial inner membrane [GO:0005743]; nucleolus [GO:0005730]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0003723; GO:0003735; GO:0005634; GO:0005730; GO:0005737; GO:0005743; GO:0005819; GO:0006412; GO:0022627; GO:0140078; GO:2001235
GN008358	GN008358.1	P43234	48.1	189	190	321	1.10e-55	181	CATO_HUMAN	Cathepsin O (EC 3.4.22.42)	Homo sapiens (Human)	proteolysis [GO:0006508]	cysteine-type endopeptidase activity [GO:0004197]	lysosome [GO:0005764]	GO:0004197; GO:0005764; GO:0006508
GN008361	GN008361.1	Q6NZQ2	50.0	524	620	687	1.58e-157	471	DDX31_MOUSE	ATP-dependent DNA helicase DDX31 (EC 5.6.2.-) (DEAD box protein 31) (Probable ATP-dependent RNA helicase DDX31) (EC 3.6.4.13)	Mus musculus (Mouse)	ribosome biogenesis [GO:0042254]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0005524; GO:0005634; GO:0005730; GO:0005794; GO:0016887; GO:0042254
GN008364	GN008364.1	Q9V6X7	48.8	381	385	402	2.82e-129	380	OFUT1_DROME	GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Neurotic protein) (Peptide-O-fucosyltransferase 1) (O-FucT-1)	Drosophila melanogaster (Fruit fly)	cell fate commitment [GO:0045165]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of protein localization to cell surface [GO:2000010]; protein O-linked glycosylation via fucose [GO:0036066]	Notch binding [GO:0005112]; peptide-O-fucosyltransferase activity [GO:0046922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	GO:0005112; GO:0005783; GO:0005788; GO:0007219; GO:0036066; GO:0045165; GO:0045747; GO:0045807; GO:0046922; GO:2000010
GN008365	GN008365.1	Q9NRR4	59.6	970	1374	1374	0.0	1148	RNC_HUMAN	Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241)	Homo sapiens (Human)	defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; positive regulation of gene expression [GO:0010628]; pre-miRNA processing [GO:0031054]; primary miRNA processing [GO:0031053]; rRNA processing [GO:0006364]	DEAD/H-box RNA helicase binding [GO:0017151]; lipopolysaccharide binding [GO:0001530]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; R-SMAD binding [GO:0070412]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; microprocessor complex [GO:0070877]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	GO:0001530; GO:0003723; GO:0004525; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0010628; GO:0014069; GO:0017151; GO:0031053; GO:0031054; GO:0042803; GO:0046332; GO:0050829; GO:0050830; GO:0070412; GO:0070877; GO:0070878; GO:0098978
GN008366	GN008366.1	Q03442	35.5	203	261	322	2.92e-32	123	CRJ1A_TRICY	Crystallin J1A	Tripedalia cystophora (Mangrove box jellyfish)				
GN008367	GN008367.1	Q9M622	53.3	45	416	310	6.52e-10	63.5	RMR1_ARATH	Receptor homology region, transmembrane domain- and RING domain-containing protein 1 (AtRMR1) (ReMembR-H2 protein JR700)	Arabidopsis thaliana (Mouse-ear cress)	intracellular protein transport [GO:0006886]; ubiquitin-dependent protein catabolic process [GO:0006511]	transcription cis-regulatory region binding [GO:0000976]; ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; protein storage vacuole membrane [GO:0032586]	GO:0000139; GO:0000976; GO:0005576; GO:0005783; GO:0006511; GO:0006886; GO:0032586; GO:0061630
GN008369	GN008369.1	Q9H8W5	23.3	451	452	580	2.02e-29	124	TRI45_HUMAN	E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99)	Homo sapiens (Human)	negative regulation of inflammatory response [GO:0050728]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0005829; GO:0008270; GO:0043161; GO:0050728; GO:0061630; GO:0070936
GN008370	GN008370.1	A0A345BJN8	32.0	203	606	919	7.16e-24	110	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN008372	GN008372.1	Q28FE4	75.7	169	173	178	3.89e-80	238	MORN5_XENTR	MORN repeat-containing protein 5	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			sperm flagellum [GO:0036126]	GO:0036126
GN008373	GN008373.1	Q01240	52.8	472	952	511	1.54e-102	332	NF60_DORPE	60 kDa neurofilament protein (NF60)	Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)	heterochromatin formation [GO:0031507]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; protein localization to nuclear envelope [GO:0090435]	structural constituent of cytoskeleton [GO:0005200]	nuclear lamina [GO:0005652]	GO:0005200; GO:0005652; GO:0006998; GO:0007097; GO:0031507; GO:0051664; GO:0090435
GN008374	GN008374.1	Q69ZR9	27.1	210	2848	1610	3.67e-14	83.2	TASOR_MOUSE	Protein TASOR (Transgene activation suppressor protein)	Mus musculus (Mouse)	anterior/posterior axis specification, embryo [GO:0008595]; constitutive heterochromatin formation [GO:0140719]; mesodermal to mesenchymal transition involved in gastrulation [GO:0060809]; negative regulation of gene expression, epigenetic [GO:0045814]; protein localization to heterochromatin [GO:0097355]; transposable element silencing by heterochromatin formation [GO:0141005]	chromatin binding [GO:0003682]; protein-macromolecule adaptor activity [GO:0030674]	chromosome [GO:0005694]; heterochromatin [GO:0000792]; HUSH complex [GO:0140283]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000792; GO:0003682; GO:0005634; GO:0005654; GO:0005694; GO:0008595; GO:0030674; GO:0045814; GO:0060809; GO:0097355; GO:0140283; GO:0140719; GO:0141005
GN008376	GN008376.1	A2VDR2	42.3	163	246	282	9.31e-40	141	ACBD6_BOVIN	Acyl-CoA-binding domain-containing protein 6	Bos taurus (Bovine)	protein myristoylation [GO:0018377]	enzyme activator activity [GO:0008047]; fatty-acyl-CoA binding [GO:0000062]	cytoplasm [GO:0005737]	GO:0000062; GO:0005737; GO:0008047; GO:0018377
GN008377	GN008377.1	Q9EQU5	79.6	206	269	289	4.15e-111	325	SET_MOUSE	Protein SET (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I)	Mus musculus (Mouse)	negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; nucleosome assembly [GO:0006334]	chromatin binding [GO:0003682]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	GO:0000785; GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005811; GO:0005829; GO:0006334; GO:0032991; GO:0043524; GO:0045892; GO:0048471
GN008378	GN008378.1	Q5FVB2	64.9	131	222	167	1.18e-60	190	LMO41_XENTR	LIM domain transcription factor LMO4.1 (LIM domain only protein 4.1) (LMO-4.1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mesoderm development [GO:0007498]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of transcription by RNA polymerase II [GO:0045944]	transcription coregulator activity [GO:0003712]	nucleus [GO:0005634]	GO:0003712; GO:0005634; GO:0007498; GO:0045665; GO:0045944
GN008383	GN008383.1	Q5ZKU5	79.9	179	178	215	1.80e-97	283	RAB14_CHICK	Ras-related protein Rab-14 (EC 3.6.5.2)	Gallus gallus (Chicken)	defense response to bacterium [GO:0042742]; endocytic recycling [GO:0032456]; fibroblast growth factor receptor signaling pathway [GO:0008543]; Golgi to endosome transport [GO:0006895]; phagolysosome assembly [GO:0001845]; regulation of embryonic development [GO:0045995]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]; phagocytic vesicle [GO:0045335]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0001845; GO:0003924; GO:0003925; GO:0005525; GO:0005769; GO:0005802; GO:0005829; GO:0006895; GO:0008543; GO:0031901; GO:0032456; GO:0042742; GO:0045335; GO:0045995; GO:0055037
GN008384	GN008384.1	Q2YDN4	27.9	383	425	500	1.74e-35	140	TEKL1_BOVIN	Tektin-like protein 1 (Coiled-coil domain-containing protein 105)	Bos taurus (Bovine)	flagellated sperm motility [GO:0030317]		axonemal B tubule inner sheath [GO:0160112]; sperm flagellum [GO:0036126]	GO:0030317; GO:0036126; GO:0160112
GN008387	GN008387.1	P21675	54.0	126	330	1893	1.43e-32	131	TAF1_HUMAN	Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)	Homo sapiens (Human)	cellular response to ATP [GO:0071318]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; midbrain development [GO:0030901]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of gene expression [GO:0010629]; negative regulation of protein autoubiquitination [GO:1905524]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of androgen receptor signaling pathway [GO:0160207]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein autophosphorylation [GO:0046777]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of signal transduction by p53 class mediator [GO:1901796]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase I promoter [GO:0006361]; transcription initiation at RNA polymerase II promoter [GO:0006367]; ubiquitin-dependent protein catabolic process [GO:0006511]	histone acetyltransferase activity [GO:0004402]; histone H4K16ac reader activity [GO:0140046]; kinase activity [GO:0016301]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-lysine-acetyltransferase activity [GO:0061733]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; TBP-class protein binding [GO:0017025]; transcription regulator inhibitor activity [GO:0140416]; ubiquitin conjugating enzyme activity [GO:0061631]	chromatin [GO:0000785]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000209; GO:0000785; GO:0000979; GO:0001091; GO:0001181; GO:0002039; GO:0004402; GO:0004672; GO:0004674; GO:0005634; GO:0005654; GO:0005667; GO:0005669; GO:0006361; GO:0006366; GO:0006367; GO:0006511; GO:0006974; GO:0010629; GO:0016251; GO:0016301; GO:0016922; GO:0017025; GO:0030901; GO:0032436; GO:0034644; GO:0042789; GO:0043565; GO:0045944; GO:0046777; GO:0046982; GO:0050821; GO:0051123; GO:0060261; GO:0061629; GO:0061631; GO:0061733; GO:0071318; GO:0071339; GO:0106310; GO:0140046; GO:0140416; GO:0160207; GO:1901796; GO:1901797; GO:1902806; GO:1905524; GO:2000059
GN008388	GN008388.1	Q60544	53.1	1395	1369	1865	0.0	1259	TAF1_MESAU	Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)	Mesocricetus auratus (Golden hamster)	positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription initiation at RNA polymerase II promoter [GO:0006367]	DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; TBP-class protein binding [GO:0017025]	MLL1 complex [GO:0071339]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]	GO:0003677; GO:0004402; GO:0004674; GO:0005634; GO:0005669; GO:0006367; GO:0016251; GO:0017025; GO:0045944; GO:0051123; GO:0071339; GO:0106310
GN008390	GN008390.1	Q91642	68.3	205	355	242	1.38e-95	287	PEPE_XENLA	Alpha-aspartyl dipeptidase (EC 3.4.13.21) (Asp-specific dipeptidase) (Dipeptidase E)	Xenopus laevis (African clawed frog)	proteolysis [GO:0006508]	dipeptidase activity [GO:0016805]; serine-type peptidase activity [GO:0008236]	cytoplasm [GO:0005737]	GO:0005737; GO:0006508; GO:0008236; GO:0016805
GN008391	GN008391.1	Q8BRG6	32.4	380	607	600	2.00e-53	195	KLH24_MOUSE	Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6)	Mus musculus (Mouse)	intermediate filament organization [GO:0045109]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	adherens junction [GO:0005912]; axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; perikaryon [GO:0043204]	GO:0005737; GO:0005912; GO:0016567; GO:0030057; GO:0030424; GO:0031463; GO:0043161; GO:0043204; GO:0045109; GO:0051865; GO:1990756
GN008392	GN008392.1	Q8BRG6	32.3	381	639	600	1.61e-57	207	KLH24_MOUSE	Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6)	Mus musculus (Mouse)	intermediate filament organization [GO:0045109]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	adherens junction [GO:0005912]; axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; perikaryon [GO:0043204]	GO:0005737; GO:0005912; GO:0016567; GO:0030057; GO:0030424; GO:0031463; GO:0043161; GO:0043204; GO:0045109; GO:0051865; GO:1990756
GN008393	GN008393.1	E9Q236	39.8	1359	1349	1325	6.71e-310	911	MRP4_MOUSE	ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 4)	Mus musculus (Mouse)	bile acid and bile salt transport [GO:0015721]; cAMP transport [GO:0070730]; cilium assembly [GO:0060271]; export across plasma membrane [GO:0140115]; kynurenic acid metabolic process [GO:0034275]; L-tryptophan metabolic process [GO:0006568]; leukotriene transport [GO:0071716]; positive regulation of smooth muscle cell proliferation [GO:0048661]; prostaglandin secretion [GO:0032310]; prostaglandin transport [GO:0015732]; urate transport [GO:0015747]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	ABC-type 3',5'-cyclic GMP transmembrane transporter activity [GO:1905948]; ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; guanine nucleotide transmembrane transporter activity [GO:0001409]; prostaglandin transmembrane transporter activity [GO:0015132]; purine nucleotide transmembrane transporter activity [GO:0015216]; transmembrane transporter activity [GO:0022857]; urate transmembrane transporter activity [GO:0015143]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; external side of apical plasma membrane [GO:0098591]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]	GO:0001409; GO:0005524; GO:0005730; GO:0005794; GO:0005886; GO:0006568; GO:0006855; GO:0008559; GO:0015132; GO:0015143; GO:0015216; GO:0015431; GO:0015432; GO:0015562; GO:0015721; GO:0015732; GO:0015747; GO:0016020; GO:0016323; GO:0016324; GO:0016887; GO:0022857; GO:0031088; GO:0032310; GO:0034275; GO:0034634; GO:0042626; GO:0042908; GO:0042910; GO:0048661; GO:0060271; GO:0070730; GO:0071716; GO:0098591; GO:0140115; GO:1905948
GN008394	GN008394.1	P61763	64.2	611	613	594	1.02e-272	761	STXB1_BOVIN	Syntaxin-binding protein 1 (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)	Bos taurus (Bovine)	axon target recognition [GO:0007412]; presynaptic dense core vesicle exocytosis [GO:0099525]; regulation of regulated secretory pathway [GO:1903305]; synaptic vesicle maturation [GO:0016188]; vesicle docking involved in exocytosis [GO:0006904]	syntaxin-1 binding [GO:0017075]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; secretory granule [GO:0030141]	GO:0005739; GO:0005829; GO:0005886; GO:0006904; GO:0007412; GO:0016188; GO:0017075; GO:0030141; GO:0098793; GO:0099525; GO:1903305
GN008395	GN008395.1	Q60980	66.1	56	393	344	1.09e-16	84.0	KLF3_MOUSE	Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2)	Mus musculus (Mouse)	cellular response to endothelin [GO:1990859]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0003677; GO:0005634; GO:0005654; GO:0006357; GO:1990837; GO:1990859
GN008396	GN008396.1	O94868	38.0	687	774	740	1.48e-123	390	FCSD2_HUMAN	F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3)	Homo sapiens (Human)	clathrin-dependent endocytosis [GO:0072583]; membrane organization [GO:0061024]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; regulation of actin filament polymerization [GO:0030833]	phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]	anchoring junction [GO:0070161]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; stereocilium shaft [GO:0120043]	GO:0005547; GO:0005737; GO:0005886; GO:0005905; GO:0007274; GO:0030833; GO:0030838; GO:0031594; GO:0043325; GO:0055037; GO:0061024; GO:0070161; GO:0072583; GO:0120043; GO:2000601
GN008397	GN008397.1	Q6GQJ2	53.4	506	994	827	8.65e-168	515	JADE1_XENLA	Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17)	Xenopus laevis (African clawed frog)	regulation of transcription by RNA polymerase II [GO:0006357]	histone reader activity [GO:0140566]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; histone acetyltransferase complex [GO:0000123]; nucleus [GO:0005634]	GO:0000123; GO:0005634; GO:0005694; GO:0005737; GO:0006357; GO:0140566
GN008398	GN008398.1	P0DPU3	33.9	540	621	577	2.96e-85	280	TX14A_SCODE	Scoloptoxin SSD14 (SLPTX-SSD14) (Toxin-SSD14) [Cleaved into: SLPTX-SSD14 subunit alpha; SLPTX-SSD14 subunit beta]	Scolopendra dehaani (Thai centipede) (Scolopendra subspinipes dehaani)	glutathione catabolic process [GO:0006751]	glutathione gamma-glutamate hydrolase [GO:0036374]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005576; GO:0005886; GO:0006751; GO:0036374
GN008399	GN008399.1	Q8IUR5	26.8	164	295	882	4.03e-12	70.1	TMTC1_HUMAN	Protein O-mannosyl-transferase TMTC1 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 1) (Transmembrane and tetratricopeptide repeat-containing 1)	Homo sapiens (Human)	protein O-linked glycosylation via mannose [GO:0035269]; RNA processing [GO:0006396]	dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	GO:0000030; GO:0004169; GO:0005783; GO:0006396; GO:0016020; GO:0035269
GN008400	GN008400.1	Q96IZ5	33.6	396	398	413	3.33e-54	187	RBM41_HUMAN	RNA-binding protein 41 (RNA-binding motif protein 41)	Homo sapiens (Human)		RNA binding [GO:0003723]	U12-type spliceosomal complex [GO:0005689]	GO:0003723; GO:0005689
GN008401	GN008401.1	Q0E908	23.9	436	1200	818	4.34e-26	119	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN008402	GN008402.1	O01391	57.9	195	242	214	2.89e-72	222	UCHL_APLCA	Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Ubiquitin thioesterase)	Aplysia californica (California sea hare)	protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511]	cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]	GO:0004843; GO:0005737; GO:0006511; GO:0016579
GN008404	GN008404.1	O75165	66.3	2254	2242	2243	0.0	3034	DJC13_HUMAN	DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8) (RME-8)	Homo sapiens (Human)	endosome organization [GO:0007032]; osteoblast differentiation [GO:0001649]; receptor-mediated endocytosis [GO:0006898]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of endocytic recycling [GO:2001135]		azurophil granule membrane [GO:0035577]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	GO:0001649; GO:0005765; GO:0005769; GO:0005886; GO:0006898; GO:0007032; GO:0010008; GO:0016020; GO:0030667; GO:0031901; GO:0035577; GO:0070062; GO:2000641; GO:2001135
GN008405	GN008405.1	H2A0L8	48.8	582	724	624	1.76e-171	508	FND2_PINMG	Fibronectin type III domain-containing protein 2	Margaritifera margaritifera (Freshwater pearl mussel)			extracellular region [GO:0005576]	GO:0005576
GN008406	GN008406.1	H2A0L8	46.2	578	661	624	2.43e-157	470	FND2_PINMG	Fibronectin type III domain-containing protein 2	Margaritifera margaritifera (Freshwater pearl mussel)			extracellular region [GO:0005576]	GO:0005576
GN008408	GN008408.1	Q9P7I3	21.9	256	402	651	2.08e-13	75.5	MDV1_SCHPO	Mitochondrial division protein 1	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	mitochondrial fission [GO:0000266]; mitochondrial membrane fission [GO:0090149]; peroxisome fission [GO:0016559]		cytoplasmic side of mitochondrial outer membrane [GO:0032473]; mitochondrion [GO:0005739]	GO:0000266; GO:0005739; GO:0016559; GO:0032473; GO:0090149
GN008414	GN008414.1	Q9UI14	49.4	156	165	185	1.60e-42	142	PRAF1_HUMAN	Prenylated Rab acceptor protein 1 (PRA1 family protein 1)	Homo sapiens (Human)		GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; proline-rich region binding [GO:0070064]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GO:0005737; GO:0005794; GO:0005886; GO:0008021; GO:0016020; GO:0042802; GO:0051020; GO:0070064; GO:0098978
GN008419	GN008419.1	Q75W84	43.6	388	383	420	2.12e-92	286	ANR_EISFE	Annetocin receptor	Eisenia fetida (Red wiggler worm)	cellular response to hormone stimulus [GO:0032870]; egg-laying behavior [GO:0018991]; G protein-coupled receptor signaling pathway [GO:0007186]	peptide binding [GO:0042277]; protein-hormone receptor activity [GO:0016500]; vasopressin receptor activity [GO:0005000]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005000; GO:0005886; GO:0007186; GO:0016020; GO:0016500; GO:0018991; GO:0032870; GO:0042277
GN008422	GN008422.1	Q9H4G4	46.8	156	486	154	3.57e-36	134	GAPR1_HUMAN	Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2)	Homo sapiens (Human)	positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	protein homodimerization activity [GO:0042803]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]	GO:0000139; GO:0010634; GO:0010718; GO:0042803; GO:0070062; GO:0070374
GN008423	GN008423.1	P50164	34.5	252	237	260	9.85e-34	125	TRN2_HYONI	Tropinone reductase 2 (EC 1.1.1.236) (Tropinone reductase II) (TR-II)	Hyoscyamus niger (Black henbane)	tropane alkaloid biosynthetic process [GO:0009710]	tropinone reductase activity [GO:0050358]		GO:0009710; GO:0050358
GN008426	GN008426.1	P96576	28.3	166	217	181	1.12e-16	77.8	YDAC_BACSU	Uncharacterized methyltransferase YdaC (EC 2.1.1.-)	Bacillus subtilis (strain 168)		methyltransferase activity [GO:0008168]		GO:0008168
GN008427	GN008427.1	Q6GQA6	55.1	187	187	195	9.76e-67	205	CSN8_XENLA	COP9 signalosome complex subunit 8 (Signalosome subunit 8)	Xenopus laevis (African clawed frog)	COP9 signalosome assembly [GO:0010387]; protein deneddylation [GO:0000338]		COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]	GO:0000338; GO:0005737; GO:0008180; GO:0010387
GN008428	GN008428.1	Q3SZK1	49.5	331	397	434	5.07e-112	337	AAMP_BOVIN	Angio-associated migratory cell protein	Bos taurus (Bovine)	positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; smooth muscle cell migration [GO:0014909]		cell surface [GO:0009986]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0009986; GO:0010595; GO:0014909; GO:0045766
GN008429	GN008429.1	Q9WV04	51.6	794	849	790	9.08e-262	750	KIF9_MOUSE	Kinesin-like protein KIF9	Mus musculus (Mouse)	extracellular matrix disassembly [GO:0022617]; microtubule-based movement [GO:0007018]; organelle disassembly [GO:1903008]; regulation of flagellated sperm motility [GO:1901317]; regulation of podosome assembly [GO:0071801]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	axonemal microtubule [GO:0005879]; cytosol [GO:0005829]; kinesin complex [GO:0005871]; microtubule [GO:0005874]; podosome [GO:0002102]; sperm flagellum [GO:0036126]; vesicle [GO:0031982]	GO:0002102; GO:0003777; GO:0005524; GO:0005829; GO:0005871; GO:0005874; GO:0005879; GO:0007018; GO:0008017; GO:0022617; GO:0031982; GO:0036126; GO:0042802; GO:0071801; GO:1901317; GO:1903008
GN008430	GN008430.1	Q9MZL5	60.0	415	555	603	4.76e-154	457	CACB2_BOVIN	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2)	Bos taurus (Bovine)	calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; chemical synaptic transmission [GO:0007268]; positive regulation of muscle contraction [GO:0045933]	high voltage-gated calcium channel activity [GO:0008331]	L-type voltage-gated calcium channel complex [GO:1990454]; synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]	GO:0005891; GO:0006816; GO:0007268; GO:0008331; GO:0045202; GO:0045933; GO:0070588; GO:1990454
GN008431	GN008431.1	O14733	74.5	314	414	419	4.31e-165	473	MP2K7_HUMAN	Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)	Homo sapiens (Human)	cellular senescence [GO:0090398]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of telomere maintenance [GO:0032206]; response to heat [GO:0009408]; response to osmotic stress [GO:0006970]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; JUN kinase kinase activity [GO:0008545]; magnesium ion binding [GO:0000287]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase binding [GO:0051019]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000287; GO:0004708; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006970; GO:0007165; GO:0007254; GO:0008545; GO:0009408; GO:0009411; GO:0019899; GO:0019901; GO:0019903; GO:0032206; GO:0034612; GO:0038095; GO:0045893; GO:0051019; GO:0051403; GO:0070374; GO:0090398; GO:0106310
GN008432	GN008432.1	A6H751	43.5	561	569	585	1.42e-149	445	FOLC_BOVIN	Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolate synthase) (Tetrahydrofolylpolyglutamate synthase)	Bos taurus (Bovine)		ATP binding [GO:0005524]; tetrahydrofolylpolyglutamate synthase activity [GO:0004326]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]	GO:0004326; GO:0005524; GO:0005743; GO:0005759; GO:0005829
GN008433	GN008433.1	P49366	69.9	349	363	369	1.18e-182	513	DHYS_HUMAN	Deoxyhypusine synthase (DHS) (EC 2.5.1.46)	Homo sapiens (Human)	peptidyl-hypusine biosynthetic process [GO:0008612]; positive regulation of cell population proliferation [GO:0008284]; protein maturation [GO:0051604]; spermidine catabolic process [GO:0046203]; spermidine metabolic process [GO:0008216]; translation [GO:0006412]	deoxyhypusine synthase activity [GO:0034038]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0006412; GO:0008216; GO:0008284; GO:0008612; GO:0034038; GO:0042802; GO:0046203; GO:0051604
GN008434	GN008434.1	Q9QX15	26.0	842	1043	902	3.34e-59	223	CA3A1_MOUSE	Calcium-activated chloride channel regulator 3A-1 (EC 3.4.-.-)	Mus musculus (Mouse)	chloride transport [GO:0006821]	intracellularly calcium-gated chloride channel activity [GO:0005229]	plasma membrane [GO:0005886]	GO:0005229; GO:0005886; GO:0006821
GN008435	GN008435.1	Q60431	32.0	266	399	277	3.42e-30	120	CASP3_MESAU	Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]	Mesocricetus auratus (Golden hamster)	apoptotic process [GO:0006915]; erythrocyte differentiation [GO:0030218]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of neuron apoptotic process [GO:0043525]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; synapse pruning [GO:0098883]	cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]	cytoplasm [GO:0005737]; death-inducing signaling complex [GO:0031264]	GO:0004175; GO:0004197; GO:0005737; GO:0006508; GO:0006915; GO:0030182; GO:0030216; GO:0030218; GO:0031264; GO:0031647; GO:0043525; GO:0098883; GO:1902004
GN008440	GN008440.1	Q9Z0U0	58.8	641	665	695	7.06e-263	742	S53A1_MOUSE	Solute carrier family 53 member 1 (Phosphate exporter SLC53A1) (Protein SYG1 homolog) (Rmc-1) (Xenotropic and polytropic retrovirus receptor 1)	Mus musculus (Mouse)	intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transmembrane transport [GO:0035435]; response to virus [GO:0009615]	efflux transmembrane transporter activity [GO:0015562]; inositol hexakisphosphate binding [GO:0000822]; phosphate transmembrane transporter activity [GO:0005315]; virus receptor activity [GO:0001618]	plasma membrane [GO:0005886]	GO:0000822; GO:0001618; GO:0005315; GO:0005886; GO:0009615; GO:0015562; GO:0030643; GO:0035435
GN008442	GN008442.1	P83111	42.0	471	550	547	1.39e-106	333	LACTB_HUMAN	Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)	Homo sapiens (Human)	proteolysis [GO:0006508]; regulation of lipid metabolic process [GO:0019216]	identical protein binding [GO:0042802]; peptidase activity [GO:0008233]	mitochondrion [GO:0005739]	GO:0005739; GO:0006508; GO:0008233; GO:0019216; GO:0042802
GN008444	GN008444.1	Q80SY5	77.7	193	413	542	9.03e-104	320	PR38B_MOUSE	Pre-mRNA-splicing factor 38B	Mus musculus (Mouse)			precatalytic spliceosome [GO:0071011]	GO:0071011
GN008445	GN008445.1	Q75WF2	33.0	336	346	358	9.25e-53	181	DNA2_ACAPL	Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta]	Acanthaster planci (Crown-of-thorns starfish)	apoptotic DNA fragmentation [GO:0006309]	deoxyribonuclease II activity [GO:0004531]	extracellular region [GO:0005576]	GO:0004531; GO:0005576; GO:0006309
GN008446	GN008446.1	Q26065	99.7	376	376	376	6.94e-279	757	ACT_PLAMG	Actin, adductor muscle (EC 3.6.4.-)	Placopecten magellanicus (Sea scallop)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN008447	GN008447.1	P80560	32.1	252	1532	1001	1.76e-22	108	PTPR2_MOUSE	Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (PTP IA-2beta) (Phogrin) (Protein tyrosine phosphatase-NP) (PTP-NP) [Cleaved into: IA-2beta71; IA-2beta64; IA-2beta60]	Mus musculus (Mouse)	insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; negative regulation of GTPase activity [GO:0034260]; neurotransmitter secretion [GO:0007269]; regulation of secretion [GO:0051046]	protein tyrosine phosphatase activity [GO:0004725]	endoplasmic reticulum lumen [GO:0005788]; presynapse [GO:0098793]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; signaling receptor complex [GO:0043235]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	GO:0004725; GO:0005788; GO:0007269; GO:0030141; GO:0030667; GO:0030672; GO:0034260; GO:0035773; GO:0043195; GO:0043235; GO:0045202; GO:0051046; GO:0098793
GN008448	GN008448.1	Q8BY02	34.6	263	640	690	1.04e-35	146	NKRF_MOUSE	NF-kappa-B-repressing factor (NFkB-repressing factor) (Transcription factor NRF)	Mus musculus (Mouse)	negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]	ATPase activator activity [GO:0001671]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0001228; GO:0001671; GO:0005634; GO:0005654; GO:0005730; GO:0045892; GO:0045944
GN008449	GN008449.1	Q3YLA4	79.5	190	195	191	6.33e-97	282	NCS1_LYMST	Neuronal calcium sensor 1 (NCS-1)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)		calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]	growth cone [GO:0030426]; perikaryon [GO:0043204]	GO:0005509; GO:0008048; GO:0030426; GO:0043204
GN008450	GN008450.1	Q9UGM3	39.5	263	730	2413	1.77e-38	158	DMBT1_HUMAN	Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Deleted in malignant brain tumors 1 protein) (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein)	Homo sapiens (Human)	defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]	calcium-dependent protein binding [GO:0048306]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]; phagocytic vesicle membrane [GO:0030670]; zymogen granule membrane [GO:0042589]	GO:0005044; GO:0005576; GO:0005737; GO:0030670; GO:0030855; GO:0031012; GO:0035375; GO:0038187; GO:0042589; GO:0043152; GO:0045087; GO:0048306; GO:0050829; GO:0050830; GO:0070062; GO:0140144
GN008452	GN008452.1	Q8TDV5	26.5	279	326	335	7.38e-14	74.7	GP119_HUMAN	Glucose-dependent insulinotropic receptor (G protein-coupled receptor 119)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]	G protein-coupled receptor activity [GO:0004930]; phosphatidylcholine binding [GO:0031210]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004930; GO:0005737; GO:0005886; GO:0007189; GO:0031210; GO:0043235
GN008453	GN008453.1	Q2KIP6	23.4	295	332	380	5.75e-14	75.5	OPRK_BOVIN	Kappa-type opioid receptor (K-OR-1) (KOR-1)	Bos taurus (Bovine)	adenylate cyclase-inhibiting opioid receptor signaling pathway [GO:0031635]; G protein-coupled opioid receptor signaling pathway [GO:0038003]; locomotory behavior [GO:0007626]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of saliva secretion [GO:0046877]; sensory perception of pain [GO:0019233]	dynorphin receptor activity [GO:0038048]; G protein-coupled opioid receptor activity [GO:0004985]; neuropeptide binding [GO:0042923]	membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	GO:0004985; GO:0005886; GO:0007200; GO:0007218; GO:0007626; GO:0016020; GO:0019233; GO:0031635; GO:0038003; GO:0038048; GO:0042923; GO:0043005; GO:0046877
GN008454	GN008454.1	Q58PK6	27.8	270	305	1236	4.57e-14	76.3	ILE2_BOMVA	Peptidylaminoacyl-L/D-isomerase polyprotein (EC 5.1.1.21) (Frog skin isomerase)	Bombina variegata (Yellow-bellied toad)				
GN008455	GN008455.1	Q58PK5	29.1	409	498	802	1.43e-25	114	ILE22_BOMVA	Peptidylaminoacyl-L/D-isomerase polyprotein 2 (EC 5.1.1.21) (Frog skin isomerase)	Bombina variegata (Yellow-bellied toad)				
GN008456	GN008456.1	Q58PK6	26.8	422	498	1236	1.33e-27	120	ILE2_BOMVA	Peptidylaminoacyl-L/D-isomerase polyprotein (EC 5.1.1.21) (Frog skin isomerase)	Bombina variegata (Yellow-bellied toad)				
GN008457	GN008457.1	Q58PK4	25.0	432	491	412	1.32e-19	94.4	ILE2_BOMOR	Peptidylaminoacyl-L/D-isomerase (EC 5.1.1.21) (Frog skin isomerase)	Bombina orientalis (Oriental fire-bellied toad)				
GN008458	GN008458.1	O01393	35.0	389	410	386	2.33e-84	265	UNC9_CAEEL	Innexin unc-9 (Uncoordinated protein 9)	Caenorhabditis elegans	monoatomic ion transmembrane transport [GO:0034220]; positive regulation of locomotion [GO:0040017]	actin filament binding [GO:0051015]; gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	cell-cell junction [GO:0005911]; gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0034220; GO:0040017; GO:0051015; GO:0055077
GN008459	GN008459.1	O01393	36.3	383	415	386	4.33e-92	285	UNC9_CAEEL	Innexin unc-9 (Uncoordinated protein 9)	Caenorhabditis elegans	monoatomic ion transmembrane transport [GO:0034220]; positive regulation of locomotion [GO:0040017]	actin filament binding [GO:0051015]; gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	cell-cell junction [GO:0005911]; gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0034220; GO:0040017; GO:0051015; GO:0055077
GN008460	GN008460.1	O01393	35.7	359	392	386	1.20e-65	216	UNC9_CAEEL	Innexin unc-9 (Uncoordinated protein 9)	Caenorhabditis elegans	monoatomic ion transmembrane transport [GO:0034220]; positive regulation of locomotion [GO:0040017]	actin filament binding [GO:0051015]; gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	cell-cell junction [GO:0005911]; gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0034220; GO:0040017; GO:0051015; GO:0055077
GN008461	GN008461.1	A8MPX8	28.5	656	692	630	3.30e-52	194	PP2D1_HUMAN	Protein phosphatase 2C-like domain-containing protein 1	Homo sapiens (Human)	negative regulation of MAPK cascade [GO:0043409]	protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004722; GO:0005634; GO:0005737; GO:0043409
GN008462	GN008462.1	Q8CDU5	47.3	583	602	853	9.51e-176	523	EFHB_MOUSE	EF-hand domain-containing family member B (Cilia- and flagella-associated protein 21)	Mus musculus (Mouse)	flagellated sperm motility [GO:0030317]; negative regulation of protein binding [GO:0032091]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of store-operated calcium entry [GO:2001256]	calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]	axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]	GO:0005509; GO:0005737; GO:0005879; GO:0030317; GO:0032091; GO:0036126; GO:0061891; GO:0070884; GO:0160111; GO:2001256
GN008463	GN008463.1	P51147	83.3	215	213	216	2.54e-118	338	RAB5C_CANLF	Ras-related protein Rab-5C (EC 3.6.5.2)	Canis lupus familiaris (Dog) (Canis familiaris)	endocytosis [GO:0006897]; endosomal transport [GO:0016197]; plasma membrane to endosome transport [GO:0048227]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; exocytic vesicle [GO:0070382]; lipid droplet [GO:0005811]; melanosome [GO:0042470]; plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005525; GO:0005769; GO:0005811; GO:0005886; GO:0006897; GO:0016197; GO:0019003; GO:0030139; GO:0031901; GO:0042470; GO:0048227; GO:0070382
GN008464	GN008464.1	Q9BZF3	53.4	116	117	934	4.93e-33	124	OSBL6_HUMAN	Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6)	Homo sapiens (Human)	bile acid biosynthetic process [GO:0006699]; intermembrane phospholipid transfer [GO:0120010]; regulation of cholesterol transport [GO:0032374]	cholesterol binding [GO:0015485]; phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity [GO:0160270]; sterol transfer activity [GO:0120015]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; endosome membrane [GO:0010008]; nuclear membrane [GO:0031965]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]	GO:0005789; GO:0005829; GO:0005886; GO:0006699; GO:0010008; GO:0015485; GO:0031901; GO:0031965; GO:0032374; GO:0097038; GO:0120010; GO:0120015; GO:0140268; GO:0160270
GN008465	GN008465.1	Q5U4Q0	50.0	78	384	628	1.72e-14	78.6	WAC_XENTR	WW domain-containing adapter protein with coiled-coil	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506]	chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993]	nucleus [GO:0005634]	GO:0000993; GO:0003682; GO:0005634; GO:0006338; GO:0006974; GO:0010506; GO:0031571; GO:0045893; GO:1904263
GN008466	GN008466.1	Q91ZU6	28.5	1885	3509	7393	5.14e-211	731	DYST_MOUSE	Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2)	Mus musculus (Mouse)	axonogenesis [GO:0007409]; cell motility [GO:0048870]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton organization [GO:0007010]; hemidesmosome assembly [GO:0031581]; intermediate filament cytoskeleton organization [GO:0045104]; intracellular transport [GO:0046907]; maintenance of cell polarity [GO:0030011]; microtubule cytoskeleton organization [GO:0000226]; regulation of microtubule polymerization or depolymerization [GO:0031110]; response to wounding [GO:0009611]; retrograde axonal transport [GO:0008090]; wound healing [GO:0042060]	calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; microtubule binding [GO:0008017]; microtubule plus-end binding [GO:0051010]; protein homodimerization activity [GO:0042803]; structural molecule activity [GO:0005198]	actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; H zone [GO:0031673]; hemidesmosome [GO:0030056]; intercalated disc [GO:0014704]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; microtubule plus-end [GO:0035371]; neurofilament cytoskeleton [GO:0060053]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; sarcolemma [GO:0042383]; stress fiber [GO:0001725]; Z disc [GO:0030018]	GO:0000226; GO:0001725; GO:0005178; GO:0005198; GO:0005509; GO:0005634; GO:0005635; GO:0005654; GO:0005737; GO:0005789; GO:0005829; GO:0005925; GO:0005938; GO:0007010; GO:0007409; GO:0008017; GO:0008090; GO:0009611; GO:0009898; GO:0014069; GO:0014704; GO:0015629; GO:0015630; GO:0016020; GO:0030011; GO:0030018; GO:0030056; GO:0030424; GO:0031110; GO:0031122; GO:0031252; GO:0031410; GO:0031581; GO:0031673; GO:0035371; GO:0042060; GO:0042383; GO:0042803; GO:0045104; GO:0045111; GO:0046907; GO:0048471; GO:0048870; GO:0051010; GO:0060053; GO:0097038; GO:1904115
GN008468	GN008468.1	G5EDE9	28.6	217	1001	611	1.02e-19	98.2	NFKI1_CAEEL	ANK repeat-containing protein nipk-1	Caenorhabditis elegans	positive regulation of cell differentiation [GO:0045597]; regulation of transcription by RNA polymerase II [GO:0006357]			GO:0006357; GO:0045597
GN008474	GN008474.1	O08590	27.7	683	710	763	2.57e-60	219	AOC3_RAT	Amine oxidase [copper-containing] 3 (EC 1.4.3.21) (Amine oxidase copper-containing 3) (Copper amine oxidase) (Semicarbazide-sensitive amine oxidase) (SSAO) (VP97) (Vascular adhesion protein 1) (VAP-1)	Rattus norvegicus (Rat)	amine metabolic process [GO:0009308]; cell adhesion [GO:0007155]; eating behavior [GO:0042755]; leukocyte migration involved in inflammatory response [GO:0002523]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of leukocyte migration [GO:0002687]; regulation of blood pressure [GO:0008217]; response to immobilization stress [GO:0035902]	calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; primary methylamine oxidase activity [GO:0008131]; protein heterodimerization activity [GO:0046982]; quinone binding [GO:0048038]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	GO:0002523; GO:0002675; GO:0002687; GO:0005507; GO:0005509; GO:0005576; GO:0005737; GO:0005769; GO:0005783; GO:0005794; GO:0005886; GO:0005902; GO:0007155; GO:0008131; GO:0008217; GO:0009308; GO:0009986; GO:0010828; GO:0016020; GO:0035902; GO:0042755; GO:0042802; GO:0046982; GO:0048038
GN008475	GN008475.1	Q12933	37.6	439	452	501	7.73e-97	303	TRAF2_HUMAN	TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)	Homo sapiens (Human)	canonical NF-kappaB signal transduction [GO:0007249]; CD27 signaling pathway [GO:0160162]; CD40 signaling pathway [GO:0023035]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; interleukin-17-mediated signaling pathway [GO:0097400]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mRNA stabilization [GO:0048255]; negative regulation of glial cell apoptotic process [GO:0034351]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of pyroptotic inflammatory response [GO:0140639]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of JNK cascade [GO:0046328]; regulation of protein-containing complex assembly [GO:0043254]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; toll-like receptor signaling pathway [GO:0002224]; TORC1 complex assembly [GO:1905669]; TORC2 complex disassembly [GO:1905670]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	CD40 receptor binding [GO:0005174]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; signaling adaptor activity [GO:0035591]; sphingolipid binding [GO:0046625]; thioesterase binding [GO:0031996]; tumor necrosis factor binding [GO:0043120]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IRE1-TRAF2-ASK1 complex [GO:1990604]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; TRAF2-GSTP1 complex [GO:0097057]; tumor necrosis factor receptor superfamily complex [GO:0002947]; ubiquitin ligase complex [GO:0000151]; vesicle membrane [GO:0012506]	GO:0000151; GO:0002224; GO:0002726; GO:0002947; GO:0004842; GO:0005164; GO:0005174; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0005938; GO:0006954; GO:0007165; GO:0007249; GO:0008270; GO:0008625; GO:0008630; GO:0009898; GO:0012506; GO:0019899; GO:0019901; GO:0019903; GO:0023035; GO:0030674; GO:0031435; GO:0031625; GO:0031996; GO:0032743; GO:0033209; GO:0034351; GO:0034976; GO:0035591; GO:0035631; GO:0038061; GO:0042110; GO:0042802; GO:0042981; GO:0043120; GO:0043123; GO:0043254; GO:0043507; GO:0044877; GO:0045121; GO:0046328; GO:0046625; GO:0048255; GO:0051865; GO:0061630; GO:0065003; GO:0070059; GO:0070534; GO:0097057; GO:0097400; GO:0140639; GO:0160162; GO:1903265; GO:1905669; GO:1905670; GO:1990604; GO:2001238
GN008477	GN008477.1	B7Q5K1	38.5	182	194	394	3.63e-40	143	QTRT2_IXOSC	Queuine tRNA-ribosyltransferase accessory subunit 2 (Queuine tRNA-ribosyltransferase domain-containing protein 1)	Ixodes scapularis (Black-legged tick) (Deer tick)	tRNA wobble guanine modification [GO:0002099]	tRNA-guanosine(34) queuine transglycosylase activity [GO:0008479]	cytoplasm [GO:0005737]	GO:0002099; GO:0005737; GO:0008479
GN008478	GN008478.1	O94967	35.1	1117	1104	919	1.54e-191	583	WDR47_HUMAN	WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin)	Homo sapiens (Human)		protein-containing complex binding [GO:0044877]	cell body [GO:0044297]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; microtubule [GO:0005874]	GO:0005737; GO:0005874; GO:0030425; GO:0030426; GO:0044297; GO:0044877
GN008479	GN008479.1	Q4KMQ2	28.6	768	947	910	1.34e-68	249	ANO6_HUMAN	Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)	Homo sapiens (Human)	activation of blood coagulation via clotting cascade [GO:0002543]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; calcium ion transmembrane transport [GO:0070588]; chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cell volume [GO:0045794]; phosphatidylserine exposure on blood platelet [GO:0097045]; plasma membrane phospholipid scrambling [GO:0017121]; pore complex assembly [GO:0046931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of potassium ion export across plasma membrane [GO:1903766]; purinergic nucleotide receptor signaling pathway [GO:0035590]; regulation of postsynaptic membrane potential [GO:0060078]; sodium ion transmembrane transport [GO:0035725]	calcium-activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; phospholipid scramblase activity [GO:0017128]; protein homodimerization activity [GO:0042803]; voltage-gated chloride channel activity [GO:0005247]; voltage-gated monoatomic ion channel activity [GO:0005244]	cell surface [GO:0009986]; chloride channel complex [GO:0034707]; cholinergic synapse [GO:0098981]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; synaptic membrane [GO:0097060]; tertiary granule membrane [GO:0070821]	GO:0002543; GO:0005227; GO:0005229; GO:0005244; GO:0005247; GO:0005254; GO:0005886; GO:0007596; GO:0009986; GO:0016020; GO:0017121; GO:0017128; GO:0030501; GO:0032060; GO:0034220; GO:0034707; GO:0034767; GO:0035579; GO:0035590; GO:0035725; GO:0042803; GO:0043065; GO:0045794; GO:0046931; GO:0060078; GO:0060100; GO:0061589; GO:0061590; GO:0070062; GO:0070588; GO:0070821; GO:0090026; GO:0097045; GO:0097060; GO:0098981; GO:1902476; GO:1903766
GN008481	GN008481.1	Q8K2G4	63.4	730	726	715	0.0	939	BBS7_MOUSE	BBSome complex member BBS7 (BBS2-like protein 1) (Bardet-Biedl syndrome 7 protein homolog)	Mus musculus (Mouse)	brain development [GO:0007420]; cilium assembly [GO:0060271]; eye development [GO:0001654]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; intracellular protein localization [GO:0008104]; limb development [GO:0060173]; non-motile cilium assembly [GO:1905515]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; primary palate development [GO:1903929]; regulation of transcription by RNA polymerase II [GO:0006357]; smoothened signaling pathway [GO:0007224]	RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	axoneme [GO:0005930]; BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cytoplasm [GO:0005737]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; photoreceptor outer segment [GO:0001750]	GO:0001654; GO:0001750; GO:0005634; GO:0005737; GO:0005813; GO:0005930; GO:0006357; GO:0007224; GO:0007420; GO:0007507; GO:0008104; GO:0016020; GO:0032436; GO:0034451; GO:0034464; GO:0036064; GO:0043005; GO:0045444; GO:0060170; GO:0060173; GO:0060271; GO:0061629; GO:1903929; GO:1905515
GN008483	GN008483.1	Q6NYB4	77.4	359	368	359	3.60e-213	590	MB211_DANRE	Putative nucleotidyltransferase MAB21L1 (EC 2.7.7.-) (Protein mab-21-like 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cornea development in camera-type eye [GO:0061303]		nucleus [GO:0005634]	GO:0005634; GO:0061303
GN008484	GN008484.1	A2VE99	74.5	369	433	425	2.66e-194	548	SEP11_BOVIN	Septin-11	Bos taurus (Bovine)	cytoskeleton-dependent cytokinesis [GO:0061640]; intracellular protein localization [GO:0008104]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; molecular adaptor activity [GO:0060090]	axon [GO:0030424]; cell division site [GO:0032153]; dendritic spine [GO:0043197]; microtubule cytoskeleton [GO:0015630]; septin complex [GO:0031105]; septin ring [GO:0005940]	GO:0003924; GO:0005525; GO:0005940; GO:0008104; GO:0015630; GO:0030424; GO:0031105; GO:0032153; GO:0043197; GO:0060090; GO:0061640
GN008485	GN008485.1	Q6PDK2	41.9	1072	2160	5588	8.74e-213	717	KMT2D_MOUSE	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	Mus musculus (Mouse)	heterochromatin formation [GO:0031507]; in utero embryonic development [GO:0001701]; oocyte growth [GO:0001555]; oogenesis [GO:0048477]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; response to estrogen [GO:0043627]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]	histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000976; GO:0001228; GO:0001555; GO:0001701; GO:0003713; GO:0005634; GO:0005654; GO:0008284; GO:0010468; GO:0031507; GO:0033148; GO:0035097; GO:0042800; GO:0043627; GO:0044666; GO:0045944; GO:0048477; GO:0140945
GN008486	GN008486.1	Q80VJ2	28.3	233	309	220	2.25e-15	77.0	SRA1_MOUSE	Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein) (SRAP)	Mus musculus (Mouse)	negative regulation of myoblast differentiation [GO:0045662]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	steroid receptor RNA activator RNA binding [GO:0002153]; transcription coactivator activity [GO:0003713]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; steroid hormone aporeceptor complex [GO:0005831]; transcription regulator complex [GO:0005667]	GO:0002153; GO:0003713; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005829; GO:0005831; GO:0005886; GO:0005929; GO:0006357; GO:0015630; GO:0045171; GO:0045662; GO:0045944
GN008494	GN008494.1	Q8CDI6	26.7	412	1274	1109	3.80e-21	104	CD158_MOUSE	Coiled-coil domain-containing protein 158	Mus musculus (Mouse)	receptor-mediated endocytosis [GO:0006898]	clathrin binding [GO:0030276]	clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]	GO:0005769; GO:0006898; GO:0030136; GO:0030276
GN008496	GN008496.1	P26714	59.8	473	1355	499	8.36e-174	529	GBRB_LYMST	Gamma-aminobutyric acid receptor subunit beta (GABA(A) receptor)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)		extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]	postsynaptic membrane [GO:0045211]	GO:0004890; GO:0005230; GO:0045211
GN008497	GN008497.1	P21783	29.2	442	352	2524	4.21e-10	65.1	NOTC1_XENLA	Neurogenic locus notch homolog protein 1 (Notch 1) (xOTCH) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]	Xenopus laevis (African clawed frog)	axon guidance [GO:0007411]; cilium assembly [GO:0060271]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; regulation of developmental process [GO:0050793]	calcium ion binding [GO:0005509]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0000122; GO:0005509; GO:0005634; GO:0005654; GO:0005886; GO:0007219; GO:0007411; GO:0009986; GO:0038023; GO:0043235; GO:0050793; GO:0060271; GO:0061314
GN008498	GN008498.1	Q9Y2T2	67.8	366	604	418	2.65e-192	549	AP3M1_HUMAN	AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin)	Homo sapiens (Human)	anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; endocytosis [GO:0006897]; Golgi to vacuole transport [GO:0006896]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; protein targeting to lysosome [GO:0006622]; vesicle-mediated transport [GO:0016192]	AP-3 adaptor complex binding [GO:0035651]; clathrin-cargo adaptor activity [GO:0035615]; small GTPase binding [GO:0031267]	AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin adaptor complex [GO:0030131]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; postsynaptic recycling endosome [GO:0098837]	GO:0005764; GO:0005765; GO:0005769; GO:0005794; GO:0006622; GO:0006896; GO:0006897; GO:0008089; GO:0016192; GO:0030123; GO:0030131; GO:0030659; GO:0031267; GO:0035615; GO:0035651; GO:0035654; GO:0048490; GO:0060155; GO:0098837; GO:0098884; GO:1903232; GO:1904115
GN008506	GN008506.1	Q86Z23	27.9	136	411	238	1.40e-09	61.6	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN008513	GN008513.1	P83425	32.6	132	143	213	3.57e-10	58.9	HIP_MYTED	Heavy metal-binding protein HIP	Mytilus edulis (Blue mussel)			extracellular region [GO:0005576]	GO:0005576
GN008517	GN008517.1	P17787	30.1	193	256	502	1.26e-23	102	ACHB2_HUMAN	Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (Human)	acetylcholine receptor signaling pathway [GO:0095500]; associative learning [GO:0008306]; B cell activation [GO:0042113]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; central nervous system projection neuron axonogenesis [GO:0021952]; cognition [GO:0050890]; lateral geniculate nucleus development [GO:0021771]; learning [GO:0007612]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; memory [GO:0007613]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; negative regulation of action potential [GO:0045759]; nervous system process [GO:0050877]; optic nerve morphogenesis [GO:0021631]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of dopamine secretion [GO:0033603]; regulation of circadian sleep/wake cycle, REM sleep [GO:0042320]; regulation of dendrite morphogenesis [GO:0048814]; regulation of dopamine metabolic process [GO:0042053]; regulation of dopamine secretion [GO:0014059]; regulation of synapse assembly [GO:0051963]; regulation of synaptic transmission, dopaminergic [GO:0032225]; response to acetylcholine [GO:1905144]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; sensory perception of pain [GO:0019233]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]; social behavior [GO:0035176]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]; vestibulocochlear nerve development [GO:0021562]; visual learning [GO:0008542]; visual perception [GO:0007601]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]	acetylcholine-gated channel complex [GO:0005892]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0001666; GO:0005886; GO:0005892; GO:0006811; GO:0006816; GO:0006939; GO:0007165; GO:0007271; GO:0007601; GO:0007605; GO:0007612; GO:0007613; GO:0007626; GO:0008306; GO:0008542; GO:0009897; GO:0014059; GO:0015276; GO:0015464; GO:0016020; GO:0019233; GO:0021562; GO:0021631; GO:0021771; GO:0021952; GO:0022848; GO:0030890; GO:0032225; GO:0033603; GO:0034220; GO:0035094; GO:0035095; GO:0035176; GO:0042053; GO:0042113; GO:0042166; GO:0042220; GO:0042320; GO:0042734; GO:0043005; GO:0044853; GO:0045202; GO:0045211; GO:0045471; GO:0045759; GO:0048814; GO:0050877; GO:0050890; GO:0051899; GO:0051963; GO:0060084; GO:0095500; GO:0097060; GO:1905144
GN008521	GN008521.1	Q9WU06	43.3	847	834	819	1.13e-225	658	AVIL_RAT	Advillin (Peripheral nervous system villin-like protein) (Pervin)	Rattus norvegicus (Rat)	actin filament organization [GO:0007015]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cilium assembly [GO:0060271]; nervous system development [GO:0007399]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of diacylglycerol biosynthetic process [GO:1900480]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	actin filament [GO:0005884]; axon [GO:0030424]; cell projection [GO:0042995]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]	GO:0003779; GO:0005546; GO:0005884; GO:0005925; GO:0007015; GO:0007399; GO:0008154; GO:0010592; GO:0010976; GO:0030027; GO:0030424; GO:0042995; GO:0043005; GO:0051014; GO:0051015; GO:0051016; GO:0060271; GO:0071933; GO:1900480
GN008522	GN008522.1	P97432	25.0	717	1073	988	5.43e-36	151	NBR1_MOUSE	Next to BRCA1 gene 1 protein (Membrane component chromosome 17 surface marker 2 homolog) (Neighbor of BRCA1 gene 1 protein)	Mus musculus (Mouse)	macroautophagy [GO:0016236]; negative regulation of osteoblast differentiation [GO:0045668]; regulation of bone mineralization [GO:0030500]; regulation of stress-activated MAPK cascade [GO:0032872]	mitogen-activated protein kinase binding [GO:0051019]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; late endosome [GO:0005770]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrial intermembrane space [GO:0005758]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; peroxisomal membrane [GO:0005778]; phagophore assembly site [GO:0000407]; signaling receptor complex [GO:0043235]	GO:0000407; GO:0005654; GO:0005737; GO:0005758; GO:0005764; GO:0005770; GO:0005776; GO:0005778; GO:0005829; GO:0008270; GO:0016236; GO:0016604; GO:0030500; GO:0031430; GO:0032872; GO:0043130; GO:0043235; GO:0045668; GO:0051019
GN008533	GN008533.1	P81491	74.5	94	144	102	2.45e-43	141	SAA5_MESAU	Serum amyloid A-5 protein	Mesocricetus auratus (Golden hamster)			extracellular region [GO:0005576]	GO:0005576
GN008534	GN008534.1	Q0P4I1	48.8	123	592	385	2.28e-28	120	CEP44_XENTR	Centrosomal protein of 44 kDa (Cep44)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	centriole replication [GO:0007099]; centriole-centriole cohesion [GO:0010457]; centrosome cycle [GO:0007098]	microtubule binding [GO:0008017]	centriole [GO:0005814]; centrosome [GO:0005813]; midbody [GO:0030496]; spindle pole [GO:0000922]	GO:0000922; GO:0005813; GO:0005814; GO:0007098; GO:0007099; GO:0008017; GO:0010457; GO:0030496
GN008535	GN008535.1	Q90744	52.0	381	407	405	5.32e-146	423	NAGAB_CHICK	Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B)	Gallus gallus (Chicken)	glycolipid catabolic process [GO:0019377]; glycoside catabolic process [GO:0016139]; oligosaccharide metabolic process [GO:0009311]	alpha-galactosidase activity [GO:0004557]; alpha-N-acetylgalactosaminidase activity [GO:0008456]	cytoplasm [GO:0005737]; lysosome [GO:0005764]	GO:0004557; GO:0005737; GO:0005764; GO:0008456; GO:0009311; GO:0016139; GO:0019377
GN008537	GN008537.1	Q9JII1	41.0	429	767	647	4.97e-106	341	INP5E_MOUSE	Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86)	Mus musculus (Mouse)	cilium assembly [GO:0060271]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of protein localization to cilium [GO:1903565]; negative regulation of translation [GO:0017148]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol metabolic process [GO:0046488]; response to inositol [GO:1902140]	inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; inositol-polyphosphate 5-phosphatase activity [GO:0004445]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:0034485]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; phosphatidylinositol-4,5-bisphosphate phosphatase activity [GO:0106019]	axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GO:0000139; GO:0001726; GO:0004439; GO:0004445; GO:0005634; GO:0005737; GO:0005794; GO:0005886; GO:0005929; GO:0005930; GO:0016314; GO:0017148; GO:0032580; GO:0034485; GO:0043813; GO:0046488; GO:0046856; GO:0051898; GO:0052658; GO:0060271; GO:0106019; GO:1902140; GO:1903565
GN008541	GN008541.1	Q8UVR3	43.6	362	342	400	6.07e-81	254	LMX1B_XENLA	LIM homeobox transcription factor 1-beta.1 (LIM homeobox protein 1b) (Xlmx1b)	Xenopus laevis (African clawed frog)	glomus development [GO:0072013]; neuron differentiation [GO:0030182]; pronephric nephron tubule development [GO:0039020]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0003700; GO:0005634; GO:0006357; GO:0030182; GO:0039020; GO:0072013
GN008542	GN008542.1	P53413	48.7	228	407	400	1.15e-67	223	LMX1B_CHICK	LIM/homeobox protein LMX-1.2 (Homeobox protein LMX-1) (LIM/homeobox protein 1) (LMX)	Gallus gallus (Chicken)	mesonephric tubule development [GO:0072164]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0030182; GO:0072164
GN008543	GN008543.1	Q9Y3P9	52.9	949	1033	1069	5.45e-304	875	RBGP1_HUMAN	Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA)	Homo sapiens (Human)	regulation of GTPase activity [GO:0043087]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; tubulin binding [GO:0015631]	centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]	GO:0005096; GO:0005813; GO:0005829; GO:0005875; GO:0015631; GO:0031267; GO:0043087
GN008544	GN008544.1	P41383	96.5	451	459	452	0.0	898	TBA2_PATVU	Tubulin alpha-2/alpha-4 chain (EC 3.6.5.-)	Patella vulgata (Common limpet)	microtubule-based process [GO:0007017]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]	microtubule [GO:0005874]	GO:0003924; GO:0005200; GO:0005525; GO:0005874; GO:0007017
GN008546	GN008546.1	Q9VVW3	48.6	321	324	327	1.06e-102	307	SFXN2_DROME	Sideroflexin-2	Drosophila melanogaster (Fruit fly)	mitochondrial transmembrane transport [GO:1990542]; one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300]	L-serine transmembrane transporter activity [GO:0015194]; monoatomic ion transmembrane transporter activity [GO:0015075]; transmembrane transporter activity [GO:0022857]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0006730; GO:0015075; GO:0015194; GO:0022857; GO:0031966; GO:0140300; GO:1990542
GN008547	GN008547.1	Q6MGA9	46.7	779	1241	798	8.29e-158	495	BRD2_RAT	Bromodomain-containing protein 2 (Protein RING3)	Rattus norvegicus (Rat)	chromatin looping [GO:0140588]; chromatin remodeling [GO:0006338]; neural tube closure [GO:0001843]; positive regulation of T-helper 17 cell lineage commitment [GO:2000330]; protein localization to chromatin [GO:0071168]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation-coupled chromatin remodeling [GO:0140673]	acetylation-dependent protein binding [GO:0140033]; histone H3K14ac reader activity [GO:0140015]; histone H4K12ac reader activity [GO:0140011]; histone H4K5ac reader activity [GO:0140012]; histone reader activity [GO:0140566]; protein serine/threonine kinase activity [GO:0004674]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0001843; GO:0004674; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006338; GO:0006355; GO:0006357; GO:0010468; GO:0016607; GO:0071168; GO:0140011; GO:0140012; GO:0140015; GO:0140033; GO:0140566; GO:0140588; GO:0140673; GO:2000330
GN008554	GN008554.1	P46060	54.7	611	613	587	2.06e-132	403	RAGP1_HUMAN	Ran GTPase-activating protein 1 (RanGAP1)	Homo sapiens (Human)	activation of GTPase activity [GO:0090630]; negative regulation of protein export from nucleus [GO:0046826]; nuclear export [GO:0051168]; protein sumoylation [GO:0016925]; signal transduction [GO:0007165]	cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]; SUMO ligase complex [GO:0106068]	GO:0003723; GO:0005096; GO:0005634; GO:0005635; GO:0005643; GO:0005654; GO:0005737; GO:0005819; GO:0005829; GO:0007165; GO:0016925; GO:0031267; GO:0031965; GO:0045296; GO:0046826; GO:0048471; GO:0051168; GO:0090630; GO:0106068
GN008555	GN008555.1	Q15811	23.5	311	1512	1721	6.79e-16	87.8	ITSN1_HUMAN	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)	Homo sapiens (Human)	clathrin-dependent synaptic vesicle endocytosis [GO:0150007]; intracellular protein localization [GO:0008104]; intracellular signal transduction [GO:0035556]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of growth hormone secretion [GO:0060124]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of postsynapse organization [GO:0099175]; regulation of small GTPase mediated signal transduction [GO:0051056]	calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085]; kinase activator activity [GO:0019209]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064]; protein-macromolecule adaptor activity [GO:0030674]	apical dendrite [GO:0097440]; calyx of Held [GO:0044305]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; intracellular vesicle [GO:0097708]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic actin cytoskeleton [GO:0098871]; postsynaptic endocytic zone [GO:0098843]; presynaptic endocytic zone [GO:0098833]; recycling endosome [GO:0055037]	GO:0005085; GO:0005509; GO:0005635; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0005886; GO:0005905; GO:0008104; GO:0012505; GO:0019209; GO:0030027; GO:0030139; GO:0030674; GO:0031410; GO:0035556; GO:0043025; GO:0043197; GO:0044305; GO:0051056; GO:0055037; GO:0060090; GO:0060124; GO:0060999; GO:0070064; GO:0097440; GO:0097708; GO:0098833; GO:0098843; GO:0098871; GO:0098978; GO:0099175; GO:0150007; GO:1905274; GO:2001288
GN008556	GN008556.1	Q5ZL74	71.6	215	218	220	6.25e-98	286	VAMP7_CHICK	Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1)	Gallus gallus (Chicken)	calcium-ion regulated exocytosis [GO:0017156]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endosome to lysosome transport [GO:0008333]; eosinophil degranulation [GO:0043308]; exocytosis [GO:0006887]; neutrophil degranulation [GO:0043312]; phagocytosis, engulfment [GO:0006911]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; neuron projection [GO:0043005]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; SNARE complex [GO:0031201]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658]	GO:0000149; GO:0005484; GO:0005765; GO:0005789; GO:0005794; GO:0006887; GO:0006888; GO:0006906; GO:0006911; GO:0008333; GO:0016192; GO:0017156; GO:0030658; GO:0030670; GO:0031201; GO:0031902; GO:0043005; GO:0043308; GO:0043312; GO:0045202; GO:0045335
GN008557	GN008557.1	Q91ZG2	52.6	289	344	326	6.31e-99	298	MPPD1_MOUSE	Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-)	Mus musculus (Mouse)		cyclic-nucleotide phosphodiesterase activity [GO:0004112]		GO:0004112
GN008559	GN008559.1	Q9QXN5	56.9	274	294	285	1.82e-115	337	MIOX_MOUSE	Inositol oxygenase (EC 1.13.99.1) (Aldehyde reductase-like 6) (Myo-inositol oxygenase) (MI oxygenase) (Renal-specific oxidoreductase)	Mus musculus (Mouse)	inositol catabolic process [GO:0019310]	alcohol dehydrogenase (NADP+) activity [GO:0008106]; ferric iron binding [GO:0008199]; inositol oxygenase activity [GO:0050113]; NADP binding [GO:0050661]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]	cytoplasm [GO:0005737]; inclusion body [GO:0016234]	GO:0005737; GO:0008106; GO:0008199; GO:0016234; GO:0016491; GO:0016651; GO:0019310; GO:0050113; GO:0050661
GN008561	GN008561.1	A6QQZ7	38.8	557	575	576	2.65e-122	375	MPP7_BOVIN	MAGUK p55 subfamily member 7	Bos taurus (Bovine)	protein localization to adherens junction [GO:0071896]		adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0005911; GO:0005912; GO:0005923; GO:0005938; GO:0016020; GO:0016328; GO:0071896
GN008565	GN008565.1	Q07553	51.5	239	700	1163	4.71e-63	231	GCY3E_DROME	Guanylate cyclase 32E (EC 4.6.1.2)	Drosophila melanogaster (Fruit fly)	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0001653; GO:0004383; GO:0005524; GO:0005886; GO:0006182; GO:0007168; GO:0035556; GO:0038023
GN008566	GN008566.1	P41384	75.8	62	710	76	4.04e-27	108	CKS1_PATVU	Cyclin-dependent kinases regulatory subunit (SUC1 homolog)	Patella vulgata (Common limpet)		cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]		GO:0016538
GN008567	GN008567.1	P70097	47.7	132	182	169	3.09e-38	132	C560_CRIGR	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (Malate dehydrogenase [quinone] cytochrome b560 subunit) (QPs-1) (QPs1)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; tricarboxylic acid cycle [GO:0006099]	electron transfer activity [GO:0009055]; heme binding [GO:0020037]; succinate dehydrogenase (quinone) activity [GO:0008177]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; respiratory chain complex II (succinate dehydrogenase) [GO:0045273]	GO:0005743; GO:0005759; GO:0006099; GO:0006121; GO:0008177; GO:0009055; GO:0020037; GO:0045273
GN008572	GN008572.1	Q8BGM5	51.0	367	729	508	3.71e-133	406	BEST2_MOUSE	Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1)	Mus musculus (Mouse)	bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; membrane depolarization [GO:0051899]; sensory perception of smell [GO:0007608]	bicarbonate channel activity [GO:0160133]; chloride channel activity [GO:0005254]; intracellularly ligand-gated monoatomic ion channel activity [GO:0005217]; ligand-gated monoatomic anion channel activity [GO:0099095]; ligand-gated monoatomic cation channel activity [GO:0099094]	basolateral plasma membrane [GO:0016323]; chloride channel complex [GO:0034707]; cilium [GO:0005929]; plasma membrane [GO:0005886]	GO:0005217; GO:0005254; GO:0005886; GO:0005929; GO:0006821; GO:0007608; GO:0015701; GO:0016323; GO:0034707; GO:0051899; GO:0099094; GO:0099095; GO:0160133; GO:1902476
GN008573	GN008573.1	Q61069	49.5	303	311	310	5.47e-74	233	USF1_MOUSE	Upstream stimulatory factor 1 (Major late transcription factor 1)	Mus musculus (Mouse)	cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; glucose mediated signaling pathway [GO:0010255]; glucose metabolic process [GO:0006006]; late viral transcription [GO:0019086]; lipid homeostasis [GO:0055088]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]	bHLH transcription factor binding [GO:0043425]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0001666; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005794; GO:0006006; GO:0006357; GO:0009411; GO:0010255; GO:0019086; GO:0019899; GO:0019901; GO:0032869; GO:0042802; GO:0042803; GO:0042826; GO:0043425; GO:0043565; GO:0044877; GO:0045893; GO:0045944; GO:0046982; GO:0055088; GO:0070888; GO:0071333; GO:1990837
GN008574	GN008574.1	Q9Y4L1	47.4	929	1031	999	2.90e-241	712	HYOU1_HUMAN	Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)	Homo sapiens (Human)	cellular response to hypoxia [GO:0071456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; response to endoplasmic reticulum stress [GO:0034976]; response to ischemia [GO:0002931]	adenyl-nucleotide exchange factor activity [GO:0000774]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein-folding chaperone binding [GO:0051087]	endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; membrane [GO:0016020]; smooth endoplasmic reticulum [GO:0005790]	GO:0000774; GO:0002931; GO:0005524; GO:0005576; GO:0005783; GO:0005788; GO:0005790; GO:0005925; GO:0006888; GO:0016020; GO:0016887; GO:0034663; GO:0034976; GO:0051087; GO:0070062; GO:0071456; GO:0071682; GO:1903298; GO:1903382
GN008576	GN008576.1	O75084	61.1	583	571	574	8.43e-244	685	FZD7_HUMAN	Frizzled-7 (Fz-7) (hFz7) (FzE3)	Homo sapiens (Human)	canonical Wnt signaling pathway [GO:0060070]; cellular response to retinoic acid [GO:0071300]; mesenchymal to epithelial transition [GO:0060231]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of ectodermal cell fate specification [GO:0042666]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphorylation [GO:0042327]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of DNA-templated transcription [GO:0006355]; stem cell population maintenance [GO:0019827]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	frizzled binding [GO:0005109]; PDZ domain binding [GO:0030165]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	endosome membrane [GO:0010008]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	GO:0005109; GO:0005546; GO:0005886; GO:0006355; GO:0010008; GO:0010812; GO:0016020; GO:0017147; GO:0019827; GO:0030165; GO:0030182; GO:0035567; GO:0042327; GO:0042666; GO:0042813; GO:0043410; GO:0045893; GO:0046330; GO:0055038; GO:0060054; GO:0060070; GO:0060071; GO:0060231; GO:0060828; GO:0071300; GO:2000726
GN008577	GN008577.1	Q84WJ2	29.3	123	338	454	5.05e-11	67.0	PRI2_ARATH	Probable DNA primase large subunit	Arabidopsis thaliana (Mouse-ear cress)	DNA replication initiation [GO:0006270]; DNA replication, synthesis of primer [GO:0006269]		alpha DNA polymerase:primase complex [GO:0005658]; nucleus [GO:0005634]; plasmodesma [GO:0009506]	GO:0005634; GO:0005658; GO:0006269; GO:0006270; GO:0009506
GN008578	GN008578.1	Q5ZML6	40.2	102	122	275	1.02e-15	73.9	MIMS1_CHICK	Mitochondrial inner membrane scaffold 1 (Protein FAM210A)	Gallus gallus (Chicken)			cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005737; GO:0005739; GO:0005743
GN008581	GN008581.1	Q20930	32.9	243	1074	509	5.41e-27	120	MIG17_CAEEL	Metalloprotease mig-17 (EC 3.4.24.-) (Abnormal cell migration protein 17)	Caenorhabditis elegans	gonad morphogenesis [GO:0035262]; intracellular protein localization [GO:0008104]; protein autoprocessing [GO:0016540]; regulation of cell migration [GO:0030334]; regulation of distal tip cell migration [GO:1903354]; zymogen activation [GO:0031638]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	basement membrane [GO:0005604]; extracellular region [GO:0005576]	GO:0004222; GO:0005576; GO:0005604; GO:0008104; GO:0008237; GO:0016540; GO:0030334; GO:0031638; GO:0035262; GO:1903354
GN008583	GN008583.1	Q8MP06	33.6	432	429	456	5.80e-64	215	SNO1_TYRJA	Senecionine N-oxygenase (SNO) (EC 1.14.13.101)	Tyria jacobaeae (Cinnabar moth)	alkaloid metabolic process [GO:0009820]; protein homotetramerization [GO:0051289]	flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; senecionine N-oxygenase activity [GO:0033784]	extracellular region [GO:0005576]	GO:0004499; GO:0005576; GO:0009820; GO:0033784; GO:0050660; GO:0050661; GO:0051289
GN008585	GN008585.1	Q7SY29	57.0	498	729	494	2.65e-184	536	G6PT3_DANRE	Glucose-6-phosphate exchanger SLC37A2 (Solute carrier family 37 member 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	glucose-6-phosphate transport [GO:0015760]; phagosome maturation [GO:0090382]; phosphate ion transmembrane transport [GO:0035435]	glucose 6-phosphate:phosphate antiporter activity [GO:0061513]	endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0015760; GO:0035435; GO:0061513; GO:0090382
GN008596	GN008596.1	O75575	56.6	129	138	148	8.04e-38	128	RPC9_HUMAN	DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17)	Homo sapiens (Human)	termination of RNA polymerase III transcription [GO:0006386]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]	calcitonin gene-related peptide receptor activity [GO:0001635]; DNA-directed RNA polymerase activity [GO:0003899]; nucleotide binding [GO:0000166]	acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; DNA polymerase III complex [GO:0009360]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase III complex [GO:0005666]	GO:0000166; GO:0001635; GO:0001669; GO:0003899; GO:0005634; GO:0005654; GO:0005666; GO:0005829; GO:0005886; GO:0006383; GO:0006384; GO:0006386; GO:0009360
GN008597	GN008597.1	P20749	40.2	214	799	454	5.42e-28	121	BCL3_HUMAN	B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3)	Homo sapiens (Human)	canonical NF-kappaB signal transduction [GO:0007249]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of translation [GO:0045727]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to UV-C [GO:0010225]; response to virus [GO:0009615]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	Bcl3-Bcl10 complex [GO:0032996]; Bcl3/NF-kappaB2 complex [GO:0033257]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0006606; GO:0006974; GO:0007249; GO:0009615; GO:0010225; GO:0030330; GO:0030674; GO:0032717; GO:0032991; GO:0032996; GO:0033257; GO:0042771; GO:0042826; GO:0042981; GO:0043066; GO:0045727; GO:0045892; GO:0045893; GO:0046426; GO:0048471; GO:0140297; GO:1901222; GO:1901223
GN008598	GN008598.1	F1RCP1	67.5	326	323	447	1.78e-144	417	BECN1_DANRE	Beclin-1	Danio rerio (Zebrafish) (Brachydanio rerio)	autophagy [GO:0006914]; cellular response to nitrogen starvation [GO:0006995]; cellular senescence [GO:0090398]; early endosome to late endosome transport [GO:0045022]; glycolytic process [GO:0006096]; heart development [GO:0007507]; late endosome to vacuole transport [GO:0045324]; mitophagy [GO:0000423]; positive regulation of autophagy [GO:0010508]; regulation of skeletal muscle tissue regeneration [GO:0043416]	phosphatidylinositol 3-kinase binding [GO:0043548]; protein-macromolecule adaptor activity [GO:0030674]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; mitochondrial membrane [GO:0031966]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]	GO:0000423; GO:0005737; GO:0005768; GO:0005776; GO:0005789; GO:0005794; GO:0006096; GO:0006914; GO:0006995; GO:0007507; GO:0010008; GO:0010508; GO:0030674; GO:0031966; GO:0034271; GO:0034272; GO:0043416; GO:0043548; GO:0045022; GO:0045324; GO:0090398
GN008600	GN008600.1	Q05AL1	55.2	650	716	673	2.92e-242	691	ARMC8_DANRE	Armadillo repeat-containing protein 8	Danio rerio (Zebrafish) (Brachydanio rerio)	animal organ development [GO:0048513]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]		cytoplasm [GO:0005737]; GID complex [GO:0034657]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005634; GO:0005737; GO:0034657; GO:0043161; GO:0048513
GN008601	GN008601.1	Q5R7B8	27.9	258	975	609	2.25e-19	97.1	KLH20_PONAB	Kelch-like protein 20	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	Golgi to endosome transport [GO:0006895]; negative regulation of apoptotic process [GO:0043066]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K33-linked ubiquitination [GO:1990390]; protein ubiquitination [GO:0016567]	type II interferon binding [GO:0019964]	axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; trans-Golgi network [GO:0005802]	GO:0005737; GO:0005802; GO:0005829; GO:0006895; GO:0016567; GO:0016605; GO:0019964; GO:0030424; GO:0030425; GO:0031463; GO:0043066; GO:0043161; GO:0048471; GO:1990390
GN008602	GN008602.1	Q8CHT3	30.7	958	1006	1018	8.37e-110	367	INT5_MOUSE	Integrator complex subunit 5 (Int5)	Mus musculus (Mouse)	regulation of transcription elongation by RNA polymerase II [GO:0034243]; RNA polymerase II transcription initiation surveillance [GO:0160240]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; INTAC complex [GO:0160232]; integrator complex [GO:0032039]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0016180; GO:0031965; GO:0032039; GO:0034243; GO:0034472; GO:0160232; GO:0160240
GN008605	GN008605.1	Q7Z0T3	50.0	102	127	125	1.46e-25	96.3	TEMPT_APLCA	Temptin	Aplysia californica (California sea hare)			extracellular region [GO:0005576]	GO:0005576
GN008606	GN008606.1	P43143	30.3	317	471	493	1.04e-32	133	ACHA6_RAT	Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Rat)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0014059; GO:0022848; GO:0030594; GO:0032991; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN008607	GN008607.1	Q9PTS8	29.9	321	456	484	1.81e-35	140	ACHA9_CHICK	Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0097060; GO:1902495
GN008608	GN008608.1	B7Z0W9	30.0	601	632	1576	1.29e-61	226	OTOP_DROME	Proton channel OtopLc (Otopetrin-Lc) (DmOtopLc)	Drosophila melanogaster (Fruit fly)	proton transmembrane transport [GO:1902600]	proton channel activity [GO:0015252]	plasma membrane [GO:0005886]	GO:0005886; GO:0015252; GO:1902600
GN008609	GN008609.1	Q9H6E4	41.3	150	211	229	9.45e-36	128	CC134_HUMAN	Coiled-coil domain-containing protein 134	Homo sapiens (Human)	positive regulation of MyD88-dependent toll-like receptor signaling pathway [GO:0034126]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of glycoprotein biosynthetic process [GO:0010559]; regulation of ossification [GO:0030278]	protein-macromolecule adaptor activity [GO:0030674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0005576; GO:0005634; GO:0005737; GO:0005788; GO:0005829; GO:0010559; GO:0016020; GO:0030177; GO:0030278; GO:0030674; GO:0034126
GN008610	GN008610.1	Q28CH8	64.1	217	228	233	6.72e-96	282	YIPF6_XENTR	Protein YIPF6 (YIP1 family member 6)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]		Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; trans-Golgi network [GO:0005802]	GO:0000138; GO:0000139; GO:0005797; GO:0005802; GO:0006888
GN008612	GN008612.1	Q28728	54.0	513	608	674	2.12e-198	575	SC5AB_RABIT	Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (rKST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11)	Oryctolagus cuniculus (Rabbit)	myo-inositol transport [GO:0015798]	D-glucose:sodium symporter activity [GO:0005412]; myo-inositol transmembrane transporter activity [GO:0005365]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005365; GO:0005412; GO:0005886; GO:0015798; GO:0016020; GO:0016324
GN008613	GN008613.1	Q28728	55.6	518	618	674	4.44e-203	587	SC5AB_RABIT	Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (rKST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11)	Oryctolagus cuniculus (Rabbit)	myo-inositol transport [GO:0015798]	D-glucose:sodium symporter activity [GO:0005412]; myo-inositol transmembrane transporter activity [GO:0005365]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005365; GO:0005412; GO:0005886; GO:0015798; GO:0016020; GO:0016324
GN008616	GN008616.1	Q28728	51.4	389	473	674	3.28e-131	397	SC5AB_RABIT	Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (rKST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11)	Oryctolagus cuniculus (Rabbit)	myo-inositol transport [GO:0015798]	D-glucose:sodium symporter activity [GO:0005412]; myo-inositol transmembrane transporter activity [GO:0005365]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005365; GO:0005412; GO:0005886; GO:0015798; GO:0016020; GO:0016324
GN008617	GN008617.1	P31639	59.5	84	96	672	2.45e-27	107	SC5A2_HUMAN	Sodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2)	Homo sapiens (Human)	alpha-glucoside transport [GO:0000017]; carbohydrate metabolic process [GO:0005975]; D-glucose import across plasma membrane [GO:0098708]; hexose transmembrane transport [GO:0008645]; renal D-glucose absorption [GO:0035623]; sodium ion import across plasma membrane [GO:0098719]	alpha-glucoside transmembrane transporter activity [GO:0015151]; D-glucose transmembrane transporter activity [GO:0055056]; D-glucose:sodium symporter activity [GO:0005412]; low-affinity D-glucose:sodium symporter activity [GO:0005362]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]	GO:0000017; GO:0005362; GO:0005412; GO:0005886; GO:0005975; GO:0008645; GO:0015151; GO:0016020; GO:0016324; GO:0035623; GO:0055056; GO:0070062; GO:0098708; GO:0098719; GO:1902495
GN008618	GN008618.1	Q28728	56.8	551	869	674	2.78e-219	638	SC5AB_RABIT	Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (rKST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11)	Oryctolagus cuniculus (Rabbit)	myo-inositol transport [GO:0015798]	D-glucose:sodium symporter activity [GO:0005412]; myo-inositol transmembrane transporter activity [GO:0005365]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005365; GO:0005412; GO:0005886; GO:0015798; GO:0016020; GO:0016324
GN008619	GN008619.1	Q3KPT0	41.8	98	375	214	3.50e-10	62.8	CC169_XENLA	Coiled-coil domain-containing protein 169	Xenopus laevis (African clawed frog)				
GN008622	GN008622.1	Q8K0U4	32.9	633	576	675	8.27e-107	338	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN008630	GN008630.1	Q92847	30.6	317	353	366	1.18e-32	128	GHSR_HUMAN	Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)	Homo sapiens (Human)	actin polymerization or depolymerization [GO:0008154]; adult feeding behavior [GO:0008343]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to thyroid hormone stimulus [GO:0097067]; decidualization [GO:0046697]; G protein-coupled receptor signaling pathway [GO:0007186]; ghrelin secretion [GO:0036321]; growth hormone secretion [GO:0030252]; hormone-mediated signaling pathway [GO:0009755]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of appetite [GO:0032099]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of macrophage apoptotic process [GO:2000110]; negative regulation of norepinephrine secretion [GO:0010700]; negative regulation of tumor necrosis factor production [GO:0032720]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of appetite [GO:0032100]; positive regulation of eating behavior [GO:1904000]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of small intestinal transit [GO:0120058]; positive regulation of small intestine smooth muscle contraction [GO:1904349]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of defecation [GO:2000292]; regulation of gastric motility [GO:1905333]; regulation of growth hormone secretion [GO:0060123]; regulation of hindgut contraction [GO:0043134]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic plasticity [GO:0048167]; regulation of transmission of nerve impulse [GO:0051969]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to follicle-stimulating hormone [GO:0032354]; response to growth hormone [GO:0060416]; response to hormone [GO:0009725]; response to L-glutamate [GO:1902065]; spermatogenesis [GO:0007283]	coreceptor activity [GO:0015026]; G protein-coupled receptor activity [GO:0004930]; growth hormone secretagogue receptor activity [GO:0001616]; growth hormone-releasing hormone receptor activity [GO:0016520]; identical protein binding [GO:0042802]; peptide hormone binding [GO:0017046]	cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]	GO:0001616; GO:0004930; GO:0005886; GO:0007186; GO:0007200; GO:0007283; GO:0007612; GO:0007613; GO:0008154; GO:0008343; GO:0009725; GO:0009755; GO:0009986; GO:0010700; GO:0015026; GO:0016520; GO:0017046; GO:0030252; GO:0032099; GO:0032100; GO:0032354; GO:0032355; GO:0032691; GO:0032715; GO:0032720; GO:0036321; GO:0040018; GO:0042802; GO:0043005; GO:0043134; GO:0045121; GO:0045923; GO:0046697; GO:0048167; GO:0050728; GO:0051969; GO:0060123; GO:0060416; GO:0071222; GO:0071548; GO:0090327; GO:0097060; GO:0097067; GO:0098685; GO:0098696; GO:0098794; GO:0098978; GO:0099170; GO:0099175; GO:0120058; GO:1902065; GO:1903672; GO:1904000; GO:1904349; GO:1905333; GO:1905564; GO:1990314; GO:2000110; GO:2000292
GN008633	GN008633.1	Q9VPQ2	71.0	335	343	354	7.29e-168	474	DJSHV_DROME	DnaJ homolog shv (Protein shriveled)	Drosophila melanogaster (Fruit fly)	germ-line stem-cell niche homeostasis [GO:0060250]; male germ-line stem cell population maintenance [GO:0036098]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of synapse maturation [GO:0090129]; protein folding [GO:0006457]; protein maturation [GO:0051604]	misfolded protein binding [GO:0051787]; receptor ligand activity [GO:0048018]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; neuromuscular junction [GO:0031594]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005576; GO:0005634; GO:0005783; GO:0005886; GO:0006457; GO:0031594; GO:0036098; GO:0048018; GO:0051604; GO:0051787; GO:0060250; GO:0090129; GO:2001046
GN008636	GN008636.1	F6ZQ54	29.1	213	704	408	3.97e-13	75.5	TRI13_XENTR	Tripartite motif containing 13	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	ERAD pathway [GO:0036503]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	GO:0005737; GO:0005789; GO:0008270; GO:0016239; GO:0016567; GO:0036503; GO:0043123; GO:0045087; GO:0061630
GN008637	GN008637.1	Q5M7V1	35.5	124	659	407	2.58e-18	91.3	TRI13_RAT	E3 ubiquitin-protein ligase TRIM13 (EC 2.3.2.27) (Putative tumor suppressor RFP2) (RING-type E3 ubiquitin transferase TRIM13) (Ret finger protein 2) (Tripartite motif-containing protein 13)	Rattus norvegicus (Rat)	antiviral innate immune response [GO:0140374]; ERAD pathway [GO:0036503]; innate immune response [GO:0045087]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; suppression of viral release by host [GO:0044790]	transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase activity [GO:0061659]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; perinuclear endoplasmic reticulum [GO:0097038]	GO:0003713; GO:0004842; GO:0005737; GO:0005789; GO:0008270; GO:0016239; GO:0036503; GO:0043123; GO:0043161; GO:0044790; GO:0045087; GO:0051865; GO:0061630; GO:0061659; GO:0097038; GO:0140374
GN008638	GN008638.1	P22448	42.2	83	88	455	5.91e-17	77.0	RARB_CHICK	Retinoic acid receptor beta (RAR-beta) (Nuclear receptor subfamily 1 group B member 2)	Gallus gallus (Chicken)	beak morphogenesis [GO:0071729]; cell differentiation [GO:0030154]; inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration [GO:0070660]; limb morphogenesis [GO:0035108]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]	nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000978; GO:0004879; GO:0005634; GO:0008270; GO:0030154; GO:0032526; GO:0035108; GO:0045944; GO:0048384; GO:0048471; GO:0070660; GO:0071729; GO:0090575
GN008640	GN008640.1	Q8WV83	51.5	470	457	523	1.97e-152	446	S35F5_HUMAN	Solute carrier family 35 member F5 (Hepatitis C virus NS5A-transactivated protein 3) (HCV NS5A-transactivated protein 3)	Homo sapiens (Human)	choline transport [GO:0015871]	choline transmembrane transporter activity [GO:0015220]	membrane [GO:0016020]	GO:0015220; GO:0015871; GO:0016020
GN008647	GN008647.1	B2RRE7	28.2	149	430	1107	1.65e-10	67.0	OTUD4_MOUSE	OTU domain-containing protein 4 (EC 3.4.19.12)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; DNA alkylation repair [GO:0006307]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; protein K11-linked deubiquitination [GO:0035871]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of protein K48-linked deubiquitination [GO:1903093]	cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578]; molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004843; GO:0005634; GO:0005737; GO:0005829; GO:0006307; GO:0034122; GO:0035871; GO:0044314; GO:0060090; GO:0061578; GO:0070536; GO:0071108; GO:0140374; GO:1903093; GO:2000660
GN008650	GN008650.1	Q05192	35.2	440	689	808	1.86e-71	251	FTF1B_DROME	Nuclear hormone receptor FTZ-F1 beta (Nuclear hormone receptor HR39) (dHR39) (Nuclear receptor subfamily 5 group B member 1)	Drosophila melanogaster (Fruit fly)	regulation of DNA-templated transcription [GO:0006355]; spermathecum morphogenesis [GO:0035211]	nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0000978; GO:0004879; GO:0005634; GO:0006355; GO:0008270; GO:0035211
GN008653	GN008653.1	Q6NSJ0	42.1	560	664	714	6.85e-161	482	MYORG_HUMAN	Alpha-galactosidase MYORG (EC 3.2.1.22) (Myogenesis regulating glycosidase) (Nuclear envelope transmembrane protein 37)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; skeletal muscle fiber development [GO:0048741]	alpha-galactosidase activity [GO:0004557]	endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]	GO:0004557; GO:0005789; GO:0005975; GO:0031965; GO:0043568; GO:0048741; GO:0051897
GN008655	GN008655.1	Q0VCN1	30.2	298	304	299	6.39e-36	134	NMRL1_BOVIN	NmrA-like family domain-containing protein 1	Bos taurus (Bovine)			nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0005634; GO:0048471
GN008657	GN008657.1	Q6UWE0	33.8	216	232	723	2.85e-30	121	LRSM1_HUMAN	E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL)	Homo sapiens (Human)	negative regulation of endocytosis [GO:0045806]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of xenophagy [GO:1904417]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent endocytosis [GO:0070086]; viral budding [GO:0046755]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0000209; GO:0004842; GO:0005737; GO:0016020; GO:0030163; GO:0045806; GO:0046755; GO:0051865; GO:0061630; GO:0070086; GO:1904417; GO:2000786
GN008658	GN008658.1	Q6YP21	54.9	419	465	454	4.96e-176	504	KAT3_HUMAN	Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III)	Homo sapiens (Human)		cysteine-S-conjugate beta-lyase activity [GO:0047804]; L-kynurenine:2-oxoglutarate transaminase activity [GO:0016212]; L-kynurenine:glyoxylate transaminase activity [GO:0047315]; pyridoxal phosphate binding [GO:0030170]; RNA binding [GO:0003723]	mitochondrion [GO:0005739]	GO:0003723; GO:0005739; GO:0016212; GO:0030170; GO:0047315; GO:0047804
GN008660	GN008660.1	Q6ZV65	26.7	404	464	393	1.04e-23	105	FA47E_HUMAN	Protein FAM47E	Homo sapiens (Human)	protein localization to chromatin [GO:0071168]; transcription initiation-coupled chromatin remodeling [GO:0045815]	enzyme activator activity [GO:0008047]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005829; GO:0008047; GO:0045815; GO:0071168
GN008686	GN008686.1	Q3ZC48	30.9	230	472	266	9.33e-19	89.4	DRAM2_BOVIN	DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77)	Bos taurus (Bovine)	photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601]		apical plasma membrane [GO:0016324]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; photoreceptor inner segment [GO:0001917]	GO:0001917; GO:0005764; GO:0005765; GO:0007601; GO:0010506; GO:0016324; GO:0045494
GN008687	GN008687.1	Q6P8D9	89.3	159	207	183	3.95e-106	305	UBC12_XENTR	NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	protein modification process [GO:0036211]; protein neddylation [GO:0045116]	NEDD8 conjugating enzyme activity [GO:0061654]; NEDD8 transferase activity [GO:0019788]; ubiquitin-protein transferase activity [GO:0004842]		GO:0004842; GO:0019788; GO:0036211; GO:0045116; GO:0061654
GN008688	GN008688.1	P02518	38.1	105	180	213	8.99e-15	72.4	HSP27_DROME	Heat shock protein 27	Drosophila melanogaster (Fruit fly)	behavioral response to starvation [GO:0042595]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; determination of adult lifespan [GO:0008340]; protein refolding [GO:0042026]; response to heat [GO:0009408]	protein folding chaperone [GO:0044183]; unfolded protein holdase activity [GO:0140309]	cytoplasm [GO:0005737]; endoplasmic reticulum chaperone complex [GO:0034663]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0008340; GO:0009408; GO:0034663; GO:0042026; GO:0042595; GO:0042742; GO:0044183; GO:0050832; GO:0140309
GN008689	GN008689.1	O08848	32.3	405	542	538	1.32e-52	190	RO60_MOUSE	RNA-binding protein Ro60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2)	Mus musculus (Mouse)	cellular response to interferon-alpha [GO:0035457]; cilium assembly [GO:0060271]; immune system development [GO:0002520]; regulation of gene expression [GO:0010468]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]	misfolded RNA binding [GO:0034336]; RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0005829; GO:0007224; GO:0009411; GO:0010468; GO:0030620; GO:0034336; GO:0035457; GO:0060271; GO:1990904
GN008690	GN008690.1	P10155	28.4	549	570	538	1.65e-52	191	RO60_HUMAN	RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2)	Homo sapiens (Human)	cellular response to interferon-alpha [GO:0035457]; regulation of gene expression [GO:0010468]; transcription by RNA polymerase III [GO:0006383]	RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005634; GO:0005737; GO:0005829; GO:0006383; GO:0010468; GO:0030620; GO:0035457; GO:1990904
GN008692	GN008692.1	A5PJJ7	58.8	68	107	316	9.27e-19	82.0	S16C6_BOVIN	Short-chain dehydrogenase/reductase family 16C member 6 (EC 1.1.1.-)	Bos taurus (Bovine)		oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	lipid droplet [GO:0005811]	GO:0005811; GO:0016616
GN008694	GN008694.1	Q8N2E2	22.7	1106	3016	1590	8.71e-38	160	VWDE_HUMAN	von Willebrand factor D and EGF domain-containing protein	Homo sapiens (Human)		signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]	GO:0005102; GO:0005576; GO:0009986
GN008695	GN008695.1	Q3TUF7	28.5	1507	1344	1407	1.41e-90	325	YETS2_MOUSE	YEATS domain-containing protein 2	Mus musculus (Mouse)	chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	histone binding [GO:0042393]; histone reader activity [GO:0140566]; modification-dependent protein binding [GO:0140030]; TBP-class protein binding [GO:0017025]; transcription corepressor activity [GO:0003714]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]	GO:0000122; GO:0003714; GO:0005634; GO:0006338; GO:0006355; GO:0006357; GO:0017025; GO:0042393; GO:0045995; GO:0051302; GO:0051726; GO:0072686; GO:0090043; GO:0140030; GO:0140566; GO:0140672
GN008699	GN008699.1	P34456	23.7	372	365	419	1.22e-25	110	YMD2_CAEEL	Uncharacterized protein F54H12.2	Caenorhabditis elegans	deoxyribonucleotide biosynthetic process [GO:0009263]	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]	cytosol [GO:0005829]	GO:0004748; GO:0005829; GO:0009263
GN008706	GN008706.1	A4IFE9	66.2	506	518	606	1.11e-252	706	TM9S1_BOVIN	Transmembrane 9 superfamily member 1	Bos taurus (Bovine)	protein localization to membrane [GO:0072657]		autophagosome membrane [GO:0000421]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]	GO:0000421; GO:0005765; GO:0016020; GO:0072657
GN008707	GN008707.1	Q86MI0	29.1	251	800	468	3.29e-20	98.2	DVE1_CAEEL	Homeobox protein dve-1 (Defective proventriculus homolog protein)	Caenorhabditis elegans	chromatin remodeling [GO:0006338]; embryo development ending in birth or egg hatching [GO:0009792]; mitochondrial unfolded protein response [GO:0034514]; regulation of innate immune response [GO:0045088]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0005667; GO:0005829; GO:0006338; GO:0006357; GO:0009792; GO:0019899; GO:0034514; GO:0044877; GO:0045088; GO:0051087
GN008709	GN008709.1	P61962	92.0	337	374	342	8.27e-244	667	DCAF7_HUMAN	DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog)	Homo sapiens (Human)	protein ubiquitination [GO:0016567]	protein-macromolecule adaptor activity [GO:0030674]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	GO:0005654; GO:0005737; GO:0005829; GO:0016363; GO:0016567; GO:0030674; GO:0031464; GO:0031465; GO:0032991; GO:0080008
GN008714	GN008714.1	Q8CBH5	30.5	584	514	775	3.13e-76	258	MFSD6_MOUSE	Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2)	Mus musculus (Mouse)	antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]	MHC class I protein binding [GO:0042288]; MHC class I receptor activity [GO:0032393]	plasma membrane [GO:0005886]	GO:0005886; GO:0032393; GO:0042288; GO:0042590
GN008716	GN008716.1	A0A286Y9D1	35.3	858	988	914	2.34e-148	467	PHF14_DANRE	PHD finger protein 14	Danio rerio (Zebrafish) (Brachydanio rerio)	lung alveolus development [GO:0048286]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of mesenchymal cell proliferation involved in lung development [GO:2000791]; negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000584]; negative regulation of transcription by RNA polymerase II [GO:0000122]	histone binding [GO:0042393]; histone reader activity [GO:0140566]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0000122; GO:0005634; GO:0008270; GO:0008285; GO:0042393; GO:0048286; GO:0072201; GO:0140566; GO:2000584; GO:2000791
GN008717	GN008717.1	Q9NRX3	34.6	81	106	87	4.13e-12	60.1	CX4L2_HUMAN	Cytochrome c oxidase hypoxia associated subunit FA4L2 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2) (NADH-ubiquinone oxidoreductase MLRQ subunit homolog) (NUOMS)	Homo sapiens (Human)	cellular response to hypoxia [GO:0071456]; negative regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902957]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; response to hypoxia [GO:0001666]	enzyme inhibitor activity [GO:0004857]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0001666; GO:0004857; GO:0005739; GO:0005743; GO:0071456; GO:1902957; GO:1903427
GN008718	GN008718.1	Q3T0D5	81.4	113	115	115	7.58e-63	189	RL30_BOVIN	Large ribosomal subunit protein eL30 (60S ribosomal protein L30)	Bos taurus (Bovine)	antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-negative bacterium [GO:0050829]; killing of cells of another organism [GO:0031640]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	GO:0002181; GO:0003723; GO:0003735; GO:0005634; GO:0005737; GO:0014069; GO:0022625; GO:0031640; GO:0050829; GO:0061844
GN008719	GN008719.1	Q91W90	47.3	368	393	417	6.38e-121	359	TXND5_MOUSE	Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Plasma cell-specific thioredoxin-related protein) (PC-TRP) (Thioredoxin-like protein p46)	Mus musculus (Mouse)	protein folding [GO:0006457]	protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]	endoplasmic reticulum lumen [GO:0005788]	GO:0003756; GO:0005788; GO:0006457; GO:0015035
GN008720	GN008720.1	P08570	69.9	73	135	112	4.44e-29	105	RLA1_DROME	Large ribosomal subunit protein P1 (60S acidic ribosomal protein P1) (Acidic ribosomal protein RPA2) (RP21C)	Drosophila melanogaster (Fruit fly)	cytoplasmic translation [GO:0002181]; translational elongation [GO:0006414]	protein kinase activator activity [GO:0030295]; ribonucleoprotein complex binding [GO:0043021]; structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]	GO:0002181; GO:0003735; GO:0006414; GO:0022625; GO:0022626; GO:0030295; GO:0043021
GN008723	GN008723.1	Q9Y2H5	46.2	106	738	1048	8.70e-18	92.0	PKHA6_HUMAN	Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)	Homo sapiens (Human)				
GN008724	GN008724.1	Q94887	38.4	1272	1307	1284	5.87e-284	841	NRX4_DROME	Neurexin-4 (Neurexin IV)	Drosophila melanogaster (Fruit fly)	axon ensheathment [GO:0008366]; cell adhesion involved in heart morphogenesis [GO:0061343]; cell-cell junction organization [GO:0045216]; dorsal closure [GO:0007391]; establishment of glial blood-brain barrier [GO:0060857]; heart process [GO:0003015]; intracellular protein localization [GO:0008104]; nerve maturation [GO:0021682]; nervous system development [GO:0007399]; presynaptic membrane assembly [GO:0097105]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]; signal transduction [GO:0007165]; synaptic target recognition [GO:0008039]; terminal button organization [GO:0072553]		plasma membrane [GO:0005886]; pleated septate junction [GO:0005919]; presynaptic active zone [GO:0048786]; synapse [GO:0045202]	GO:0003015; GO:0005886; GO:0005919; GO:0007165; GO:0007391; GO:0007399; GO:0008039; GO:0008104; GO:0008366; GO:0019991; GO:0021682; GO:0035151; GO:0045202; GO:0045216; GO:0048786; GO:0060857; GO:0061343; GO:0072553; GO:0097105
GN008725	GN008725.1	Q03172	33.3	90	1776	2688	2.47e-09	66.6	ZEP1_MOUSE	Zinc finger protein 40 (Alpha A-crystallin-binding protein 1) (Alpha A-CRYBP1) (Alpha A-crystallin-binding protein I) (Transcription factor alphaA-CRYBP1)	Mus musculus (Mouse)	BMP signaling pathway [GO:0030509]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0003677; GO:0005634; GO:0005654; GO:0005739; GO:0005829; GO:0006357; GO:0008270; GO:0016604; GO:0030509; GO:0045892; GO:0045944; GO:0071837; GO:1990837
GN008726	GN008726.1	Q5R9I5	70.0	480	567	501	2.24e-246	688	SYDC_PONAB	Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	aspartyl-tRNA aminoacylation [GO:0006422]	aspartate-tRNA ligase activity [GO:0004815]; ATP binding [GO:0005524]; RNA binding [GO:0003723]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytosol [GO:0005829]	GO:0003723; GO:0004815; GO:0005524; GO:0005829; GO:0006422; GO:0017101
GN008729	GN008729.1	Q9UJ83	59.8	564	571	578	2.35e-249	699	HACL1_HUMAN	2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2)	Homo sapiens (Human)	fatty acid alpha-oxidation [GO:0001561]; fatty acid metabolic process [GO:0006631]; methyl-branched fatty acid metabolic process [GO:0097089]; phytanic acid metabolic process [GO:1903512]; protein targeting to peroxisome [GO:0006625]	2-hydroxyacyl-CoA lyase activity [GO:0106359]; 2-hydroxyphytanoyl-CoA lyase activity [GO:0106376]; ATP binding [GO:0005524]; carbon-carbon lyase activity [GO:0016830]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0000287; GO:0001561; GO:0005524; GO:0005777; GO:0005782; GO:0005829; GO:0006625; GO:0006631; GO:0016830; GO:0030976; GO:0042802; GO:0097089; GO:0106359; GO:0106376; GO:1903512
GN008730	GN008730.1	Q6DHF7	45.7	341	449	380	1.33e-89	280	GTPBA_DANRE	GTP-binding protein 10	Danio rerio (Zebrafish) (Brachydanio rerio)	mitochondrial large ribosomal subunit assembly [GO:1902775]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	GO:0000287; GO:0003924; GO:0005525; GO:0005730; GO:0005739; GO:0005759; GO:1902775
GN008731	GN008731.1	Q3ZCF3	84.7	131	144	163	8.84e-66	200	SKP1_BOVIN	S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)	Bos taurus (Bovine)	protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cullin family protein binding [GO:0097602]	Cul7-RING ubiquitin ligase complex [GO:0031467]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005829; GO:0016567; GO:0019005; GO:0031146; GO:0031467; GO:0097602
GN008737	GN008737.1	P08430	31.4	523	504	529	4.96e-55	196	UD16_RAT	UDP-glucuronosyltransferase 1A6 (UGT1A6) (EC 2.4.1.17) (A1) (P-nitrophenol-specific UDPGT) (UDP-glucuronosyltransferase 1-6) (UDPGT 1-6) (UGT1*6) (UGT1-06) (UGT1.6)	Rattus norvegicus (Rat)	4-chlorobiphenyl metabolic process [GO:0018880]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hormone stimulus [GO:0032870]; estrogen metabolic process [GO:0008210]; flavone metabolic process [GO:0051552]; liver development [GO:0001889]; response to 3-methylcholanthrene [GO:1904681]; response to Aroclor 1254 [GO:1904010]; response to lipopolysaccharide [GO:0032496]; response to peptide hormone [GO:0043434]; xenobiotic metabolic process [GO:0006805]	enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; protein-containing complex [GO:0032991]	GO:0001889; GO:0004857; GO:0005783; GO:0005789; GO:0006805; GO:0008210; GO:0015020; GO:0018880; GO:0019899; GO:0032496; GO:0032870; GO:0032991; GO:0042803; GO:0043434; GO:0044877; GO:0046982; GO:0051552; GO:0071385; GO:1904010; GO:1904681
GN008738	GN008738.1	P78417	44.4	196	241	241	4.50e-51	169	GSTO1_HUMAN	Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R)	Homo sapiens (Human)	cellular response to arsenic-containing substance [GO:0071243]; glutathione metabolic process [GO:0006749]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014810]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; xenobiotic catabolic process [GO:0042178]	glutathione dehydrogenase (ascorbate) activity [GO:0045174]; glutathione transferase activity [GO:0004364]; methylarsonate reductase activity [GO:0050610]; oxidoreductase activity [GO:0016491]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0004364; GO:0005737; GO:0005829; GO:0006749; GO:0010880; GO:0010881; GO:0014810; GO:0016491; GO:0019852; GO:0042178; GO:0045174; GO:0050610; GO:0051280; GO:0051281; GO:0070062; GO:0071243
GN008739	GN008739.1	P07872	48.8	648	661	661	1.58e-224	643	ACOX1_RAT	Peroxisomal acyl-coenzyme A oxidase 1 (ACO) (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]	Rattus norvegicus (Rat)	cholesterol homeostasis [GO:0042632]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid biosynthetic process [GO:0006633]; fatty acid catabolic process [GO:0009062]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; hydrogen peroxide biosynthetic process [GO:0050665]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; peroxisome fission [GO:0016559]; prostaglandin metabolic process [GO:0006693]; spermatogenesis [GO:0007283]; very long-chain fatty acid beta-oxidation [GO:0140493]; very long-chain fatty acid metabolic process [GO:0000038]	acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; long-chain fatty acyl-CoA oxidase activity [GO:0120524]; medium-chain fatty acyl-CoA oxidase activity [GO:0120523]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; very-long-chain fatty acyl-CoA oxidase activity [GO:0044535]	cytoplasm [GO:0005737]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0000038; GO:0003997; GO:0005504; GO:0005737; GO:0005777; GO:0005778; GO:0005782; GO:0006091; GO:0006629; GO:0006633; GO:0006693; GO:0007283; GO:0009062; GO:0016559; GO:0019395; GO:0030165; GO:0033540; GO:0042632; GO:0042803; GO:0044535; GO:0050660; GO:0050665; GO:0055088; GO:0071949; GO:0120523; GO:0120524; GO:0140493
GN008743	GN008743.1	Q9Z1N0	51.4	662	668	661	2.77e-237	676	ACOX1_CAVPO	Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]	Cavia porcellus (Guinea pig)	fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; prostaglandin metabolic process [GO:0006693]; very long-chain fatty acid metabolic process [GO:0000038]	acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; long-chain fatty acyl-CoA oxidase activity [GO:0120524]; medium-chain fatty acyl-CoA oxidase activity [GO:0120523]; very-long-chain fatty acyl-CoA oxidase activity [GO:0044535]	peroxisome [GO:0005777]	GO:0000038; GO:0003997; GO:0005504; GO:0005777; GO:0006091; GO:0006629; GO:0006693; GO:0019395; GO:0033540; GO:0044535; GO:0055088; GO:0071949; GO:0120523; GO:0120524
GN008748	GN008748.1	Q6P8A7	54.7	234	218	226	1.01e-61	195	RBM24_XENTR	RNA-binding protein 24 (RNA-binding motif protein 24)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	3'-UTR-mediated mRNA destabilization [GO:0061158]; DNA damage response [GO:0006974]; mRNA destabilization [GO:0061157]; mRNA stabilization [GO:0048255]; negative regulation of cytoplasmic translation [GO:2000766]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of skeletal muscle fiber differentiation [GO:1902811]; positive regulation of stem cell differentiation [GO:2000738]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA stability [GO:0043488]; regulation of myotube differentiation [GO:0010830]	mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA CDS binding [GO:1990715]; pre-mRNA intronic binding [GO:0097157]; sequence-specific mRNA binding [GO:1990825]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000381; GO:0003730; GO:0005634; GO:0005737; GO:0005829; GO:0006974; GO:0010830; GO:0010831; GO:0035925; GO:0043488; GO:0045663; GO:0048255; GO:0061157; GO:0061158; GO:0097157; GO:1902811; GO:1905870; GO:1990715; GO:1990825; GO:2000738; GO:2000766
GN008751	GN008751.1	A2VE54	28.2	436	479	457	3.70e-45	167	UN93A_BOVIN	N-acetylglucosamine transporter UNC93A (Protein unc-93 homolog A) (Unc-93A)	Bos taurus (Bovine)		N-acetylglucosamine transmembrane transporter activity [GO:0015572]	plasma membrane [GO:0005886]	GO:0005886; GO:0015572
GN008752	GN008752.1	Q9Y115	29.0	421	442	538	1.61e-41	157	UN93L_DROME	UNC93-like protein	Drosophila melanogaster (Fruit fly)	inorganic ion homeostasis [GO:0098771]; regulation of muscle contraction [GO:0006937]; regulation of potassium ion transport [GO:0043266]; renal system process [GO:0003014]; transmembrane transport [GO:0055085]	potassium channel regulator activity [GO:0015459]; transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; plasma membrane [GO:0005886]; striated muscle dense body [GO:0055120]	GO:0003014; GO:0005886; GO:0006937; GO:0015459; GO:0016020; GO:0022857; GO:0043266; GO:0055085; GO:0055120; GO:0098771
GN008753	GN008753.1	Q6DDL7	25.5	463	479	460	2.82e-45	167	UN93A_XENLA	N-acetylglucosamine transporter UNC93A (Protein unc-93 homolog A) (Unc-93A)	Xenopus laevis (African clawed frog)		N-acetylglucosamine transmembrane transporter activity [GO:0015572]	plasma membrane [GO:0005886]	GO:0005886; GO:0015572
GN008755	GN008755.1	P10351	32.7	1312	1522	1335	2.35e-192	610	XDH_DROME	Xanthine dehydrogenase (XD) (EC 1.17.1.4) (Protein rosy locus)	Drosophila melanogaster (Fruit fly)	compound eye pigmentation [GO:0048072]; determination of adult lifespan [GO:0008340]; glycerophospholipid metabolic process [GO:0006650]; purine nucleobase metabolic process [GO:0006144]; pyrimidine nucleobase metabolic process [GO:0006206]; xanthine catabolic process [GO:0009115]	2 iron, 2 sulfur cluster binding [GO:0051537]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; xanthine dehydrogenase activity [GO:0004854]	peroxisome [GO:0005777]	GO:0004854; GO:0005506; GO:0005777; GO:0006144; GO:0006206; GO:0006650; GO:0008340; GO:0009115; GO:0043546; GO:0048072; GO:0050660; GO:0051537; GO:0071949
GN008756	GN008756.1	Q92005	85.2	460	461	462	8.89e-291	795	EF1A_DANRE	Elongation factor 1-alpha (EF-1-alpha) (EC 3.6.5.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	translation [GO:0006412]; translational elongation [GO:0006414]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]	cytoplasm [GO:0005737]	GO:0003746; GO:0003924; GO:0005525; GO:0005737; GO:0006412; GO:0006414
GN008760	GN008760.1	Q92609	42.0	667	811	795	1.41e-154	474	TBCD5_HUMAN	TBC1 domain family member 5	Homo sapiens (Human)	autophagy [GO:0006914]; macroautophagy [GO:0016236]; positive regulation of receptor internalization [GO:0002092]; response to starvation [GO:0042594]; retrograde transport, endosome to Golgi [GO:0042147]	AP-2 adaptor complex binding [GO:0035612]; GTPase activator activity [GO:0005096]; protein-containing complex binding [GO:0044877]; retromer complex binding [GO:1905394]	autophagosome [GO:0005776]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; retromer complex [GO:0030904]	GO:0002092; GO:0005096; GO:0005776; GO:0005794; GO:0005829; GO:0006914; GO:0010008; GO:0016236; GO:0030904; GO:0035612; GO:0042147; GO:0042594; GO:0044877; GO:1905394
GN008761	GN008761.1	Q2TBG9	47.4	135	220	297	1.97e-37	135	TM169_BOVIN	Transmembrane protein 169	Bos taurus (Bovine)			membrane [GO:0016020]	GO:0016020
GN008765	GN008765.1	O02827	33.7	95	458	438	3.54e-12	71.6	MYLK_SHEEP	Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]	Ovis aries (Sheep)	positive regulation of vascular associated smooth muscle contraction [GO:1904695]; tonic smooth muscle contraction [GO:0014820]	ATP binding [GO:0005524]; myosin light chain kinase activity [GO:0004687]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; stress fiber [GO:0001725]	GO:0001725; GO:0004687; GO:0005524; GO:0005737; GO:0014820; GO:0030027; GO:0032154; GO:1904695
GN008767	GN008767.1	O88873	26.1	268	460	529	2.42e-22	103	GMEB2_RAT	Glucocorticoid modulatory element-binding protein 2 (GMEB-2)	Rattus norvegicus (Rat)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0005654; GO:0005829; GO:0006357; GO:0042802; GO:0043565; GO:0045944; GO:1990837
GN008768	GN008768.1	O60645	42.9	687	733	745	3.01e-181	538	EXOC3_HUMAN	Exocyst complex component 3 (Exocyst complex component Sec6)	Homo sapiens (Human)	exocyst localization [GO:0051601]; exocytosis [GO:0006887]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	cadherin binding [GO:0045296]; SNARE binding [GO:0000149]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; secretory granule membrane [GO:0030667]	GO:0000145; GO:0000149; GO:0000281; GO:0005737; GO:0005794; GO:0005829; GO:0006887; GO:0006904; GO:0030426; GO:0030496; GO:0030667; GO:0045296; GO:0048471; GO:0051601; GO:0090148; GO:0090522
GN008770	GN008770.1	Q8IYG6	38.4	385	664	542	1.57e-57	206	LRC56_HUMAN	Leucine-rich repeat-containing protein 56	Homo sapiens (Human)			cilium [GO:0005929]	GO:0005929
GN008776	GN008776.1	Q0V8J4	29.8	447	566	891	2.63e-36	148	VWA7_BOVIN	von Willebrand factor A domain-containing protein 7 (Protein G7c)	Bos taurus (Bovine)			extracellular region [GO:0005576]	GO:0005576
GN008778	GN008778.1	Q9JHA8	27.5	327	1052	891	2.18e-23	110	VWA7_MOUSE	von Willebrand factor A domain-containing protein 7 (Protein G7c)	Mus musculus (Mouse)			extracellular region [GO:0005576]	GO:0005576
GN008781	GN008781.1	Q9FT72	35.4	99	148	713	2.00e-09	58.2	RQL3_ARATH	ATP-dependent DNA helicase Q-like 3 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ3) (RecQ-like protein 3) (AtRecQ3) (AtRecQl3)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004386; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006310; GO:0009378; GO:0016887; GO:0043138; GO:1990814
GN008786	GN008786.1	Q5ZMD4	34.1	85	131	408	2.80e-09	57.0	TRI59_CHICK	Tripartite motif-containing protein 59	Gallus gallus (Chicken)	innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0008270; GO:0043124; GO:0045087; GO:0061630
GN008789	GN008789.1	Q14191	28.6	409	387	1432	3.13e-31	129	WRN_HUMAN	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Homo sapiens (Human)	base-excision repair [GO:0006284]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; mismatch repair [GO:0006298]; positive regulation of strand invasion [GO:0098530]; protein localization to nucleolus [GO:1902570]; replication fork processing [GO:0031297]; response to UV-C [GO:0010225]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; 3'-flap-structured DNA binding [GO:0070337]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bubble DNA binding [GO:0000405]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; exonuclease activity [GO:0004527]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MutLalpha complex binding [GO:0032405]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]	centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000287; GO:0000400; GO:0000403; GO:0000405; GO:0000723; GO:0000731; GO:0000781; GO:0003677; GO:0003678; GO:0004527; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005730; GO:0005737; GO:0005813; GO:0006259; GO:0006260; GO:0006284; GO:0006298; GO:0006302; GO:0006310; GO:0006974; GO:0008408; GO:0009267; GO:0009378; GO:0010225; GO:0016607; GO:0016887; GO:0030145; GO:0031297; GO:0032201; GO:0032392; GO:0032405; GO:0042803; GO:0043138; GO:0044877; GO:0051880; GO:0061749; GO:0061820; GO:0061821; GO:0061849; GO:0070337; GO:0071480; GO:0090398; GO:0090656; GO:0098530; GO:1902570; GO:1905773
GN008792	GN008792.1	Q99K70	64.7	377	375	398	1.49e-162	464	RRAGC_MOUSE	Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929)	Mus musculus (Mouse)	autophagosome assembly [GO:0000045]; cellular response to amino acid starvation [GO:0034198]; cellular response to nutrient levels [GO:0031669]; cellular response to starvation [GO:0009267]; cytoplasmic translation [GO:0002181]; lysosome organization [GO:0007040]; negative regulation of autophagy [GO:0010507]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of translational initiation [GO:0045947]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of translational initiation [GO:0045948]; protein destabilization [GO:0031648]; protein localization to lysosome [GO:0061462]; protein localization to membrane [GO:0072657]; regulation of TOR signaling [GO:0032006]; regulation of TORC1 signaling [GO:1903432]; response to amino acid [GO:0043200]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; TORC1 signaling [GO:0038202]	enzyme-substrate adaptor activity [GO:0140767]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; molecular adaptor activity [GO:0060090]; protein heterodimerization activity [GO:0046982]; protein-membrane adaptor activity [GO:0043495]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; FNIP-folliculin RagC/D GAP [GO:1990877]; Gtr1-Gtr2 GTPase complex [GO:1990131]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000045; GO:0002181; GO:0003924; GO:0005525; GO:0005634; GO:0005654; GO:0005737; GO:0005764; GO:0005765; GO:0005829; GO:0007040; GO:0009267; GO:0010507; GO:0019003; GO:0031146; GO:0031648; GO:0031669; GO:0032006; GO:0032008; GO:0034198; GO:0038202; GO:0043200; GO:0043495; GO:0045947; GO:0045948; GO:0046982; GO:0051020; GO:0060090; GO:0061462; GO:0072657; GO:0140767; GO:1900181; GO:1903432; GO:1904263; GO:1990131; GO:1990877
GN008793	GN008793.1	Q5U4X5	29.1	571	636	640	2.02e-65	229	NDC80_XENTR	Kinetochore protein NDC80 homolog (Kinetochore protein Hec1) (Kinetochore-associated protein 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; chromosome segregation [GO:0007059]; G2/MI transition of meiotic cell cycle [GO:0008315]; metaphase chromosome alignment [GO:0051310]; mitotic spindle organization [GO:0007052]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; spindle assembly involved in female meiosis I [GO:0007057]	kinetochore adaptor activity [GO:0140483]; microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; Ndc80 complex [GO:0031262]; nucleus [GO:0005634]	GO:0000776; GO:0005634; GO:0005737; GO:0005813; GO:0007052; GO:0007057; GO:0007059; GO:0008017; GO:0008315; GO:0031262; GO:0051310; GO:0051315; GO:0090267; GO:0140483
GN008794	GN008794.1	A1A5V7	65.1	249	279	282	2.37e-111	325	TM41B_DANRE	Transmembrane protein 41B (Protein stasimon)	Danio rerio (Zebrafish) (Brachydanio rerio)	autophagosome assembly [GO:0000045]; motor neuron axon guidance [GO:0008045]	phospholipid scramblase activity [GO:0017128]	endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]	GO:0000045; GO:0005789; GO:0008045; GO:0012505; GO:0017128; GO:0044233
GN008795	GN008795.1	Q2KHP8	58.2	649	665	735	1.42e-262	743	TYW1_XENLA	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA wybutosine-synthesizing protein 1 homolog) (tRNA-yW-synthesizing protein)	Xenopus laevis (African clawed frog)	wybutosine biosynthetic process [GO:0031591]	4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; tRNA-4-demethylwyosine synthase activity [GO:0102521]		GO:0010181; GO:0031591; GO:0051539; GO:0102521
GN008796	GN008796.1	O95922	68.9	421	418	423	1.38e-227	631	TTLL1_HUMAN	Polyglutamylase complex subunit TTLL1 (EC 6.3.2.-) (Tubulin polyglutamylase TTLL1) (Tubulin polyglutamylase complex subunit 3) (PGs3) (Tubulin--tyrosine ligase-like protein 1)	Homo sapiens (Human)	microtubule cytoskeleton organization [GO:0000226]; protein polyglutamylation [GO:0018095]; sperm axoneme assembly [GO:0007288]	protein-glutamic acid ligase activity, elongating [GO:0106438]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	axoneme [GO:0005930]; catalytic complex [GO:1902494]; ciliary basal body [GO:0036064]; microtubule [GO:0005874]; motile cilium [GO:0031514]	GO:0000226; GO:0005874; GO:0005930; GO:0007288; GO:0015631; GO:0018095; GO:0031514; GO:0036064; GO:0070740; GO:0106438; GO:1902494
GN008797	GN008797.1	Q5ZL77	41.2	546	537	539	7.29e-120	366	RIC8A_CHICK	Chaperone Ric-8A (Synembryn-A)	Gallus gallus (Chicken)	G protein-coupled receptor signaling pathway [GO:0007186]	G-protein alpha-subunit binding [GO:0001965]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein folding chaperone [GO:0044183]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0001965; GO:0005085; GO:0005737; GO:0005886; GO:0005938; GO:0007186; GO:0044183
GN008798	GN008798.1	Q7S8J7	26.3	555	1415	1584	2.02e-36	154	DCL1_NEUCR	Dicer-like protein 1 [Includes: Endoribonuclease dcl-1 (EC 3.1.26.-); ATP-dependent helicase dcl-1 (EC 3.6.4.-)]	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	siRNA processing [GO:0030422]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003677; GO:0003723; GO:0004525; GO:0005524; GO:0005634; GO:0005737; GO:0030422
GN008800	GN008800.1	P51452	43.9	173	194	185	4.85e-44	147	DUS3_HUMAN	Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR)	Homo sapiens (Human)	cellular response to epidermal growth factor stimulus [GO:0071364]; dephosphorylation [GO:0016311]; negative regulation of cell migration [GO:0030336]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of focal adhesion assembly [GO:0051893]	cytoskeletal protein binding [GO:0008092]; MAP kinase phosphatase activity [GO:0033549]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; receptor signaling protein tyrosine kinase inhibitor activity [GO:0030294]; receptor tyrosine kinase binding [GO:0030971]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001772; GO:0004722; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0008092; GO:0008138; GO:0016311; GO:0016791; GO:0019901; GO:0030294; GO:0030336; GO:0030971; GO:0033549; GO:0035335; GO:0042059; GO:0043409; GO:0045931; GO:0046329; GO:0050860; GO:0050868; GO:0050922; GO:0051893; GO:0070373; GO:0071364; GO:0120183; GO:1990782
GN008803	GN008803.1	Q9UMX9	29.6	588	692	530	2.25e-66	231	S45A2_HUMAN	Membrane-associated transporter protein (Melanoma antigen AIM1) (Protein AIM-1) (Solute carrier family 45 member 2)	Homo sapiens (Human)	developmental pigmentation [GO:0048066]; lysosomal lumen pH elevation [GO:0035752]; melanin biosynthetic process from tyrosine [GO:0006583]; sucrose transport [GO:0015770]	D-glucose:proton symporter activity [GO:0005356]; sucrose:proton symporter activity [GO:0008506]	melanosome membrane [GO:0033162]	GO:0005356; GO:0006583; GO:0008506; GO:0015770; GO:0033162; GO:0035752; GO:0048066
GN008805	GN008805.1	Q0EEE2	28.9	852	908	906	6.45e-91	311	PTHD3_MOUSE	Patched domain-containing protein 3 (RND-type protein RNDEu-3)	Mus musculus (Mouse)			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; sperm midpiece [GO:0097225]	GO:0005783; GO:0005789; GO:0016020; GO:0097225
GN008807	GN008807.1	Q711G3	44.4	232	564	249	4.96e-60	202	IAH1_RAT	Isoamyl acetate-hydrolyzing esterase 1 homolog (EC 3.1.-.-) (Hypertrophic agonist-responsive protein B64)	Rattus norvegicus (Rat)	gene expression [GO:0010467]	hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]		GO:0010467; GO:0016788; GO:0042802
GN008808	GN008808.1	Q9TU53	24.6	564	970	3620	5.31e-18	94.0	CUBN_CANLF	Cubilin	Canis lupus familiaris (Dog) (Canis familiaris)		calcium ion binding [GO:0005509]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; endosome [GO:0005768]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0005509; GO:0005765; GO:0005768; GO:0005886; GO:0016324; GO:0031526; GO:0043235
GN008815	GN008815.1	Q6NZG4	33.6	131	532	898	2.79e-15	82.8	DDIAS_MOUSE	DNA damage-induced apoptosis suppressor protein (Nitric oxide-inducible gene protein)	Mus musculus (Mouse)	cellular response to cytokine stimulus [GO:0071345]; cellular response to gamma radiation [GO:0071480]; cellular response to hydroperoxide [GO:0071447]; cellular response to UV [GO:0034644]; DNA damage response [GO:0006974]; hemopoiesis [GO:0030097]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; regulation of cell cycle [GO:0051726]; regulation of DNA stability [GO:0097752]; spermatid development [GO:0007286]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0006974; GO:0007286; GO:0030097; GO:0034644; GO:0051726; GO:0071345; GO:0071447; GO:0071480; GO:0097752; GO:1902230; GO:2000270
GN008817	GN008817.1	P15287	45.1	490	537	525	3.97e-150	443	AGSA_APLCA	Adenosine deaminase AGSA (EC 3.5.4.4) (Atrial gland-specific antigen) (AGSA) (Mollusk-derived growth factor) (MDGF)	Aplysia californica (California sea hare)	adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103]	adenosine deaminase activity [GO:0004000]	extracellular region [GO:0005576]	GO:0004000; GO:0005576; GO:0006154; GO:0046103
GN008818	GN008818.1	Q9H6K1	57.6	224	399	298	4.86e-84	261	ILRUN_HUMAN	Protein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein)	Homo sapiens (Human)	macroautophagy [GO:0016236]; negative regulation of defense response to virus [GO:0050687]; negative regulation of DNA binding [GO:0043392]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon production [GO:0032480]	ubiquitin binding [GO:0043130]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; phagophore assembly site [GO:0000407]	GO:0000407; GO:0005634; GO:0005737; GO:0005829; GO:0016236; GO:0016607; GO:0032480; GO:0032720; GO:0043130; GO:0043392; GO:0050687; GO:1900181
GN008820	GN008820.1	B0BNF8	49.4	168	183	242	8.70e-52	169	HTAI2_RAT	Protein HTATIP2	Rattus norvegicus (Rat)	positive regulation of programmed cell death [GO:0043068]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]	protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0004674; GO:0005737; GO:0005739; GO:0005829; GO:0043068; GO:0045944; GO:0046777
GN008823	GN008823.1	Q5GLH2	55.1	350	341	343	1.94e-121	356	TRIB2_BOVIN	Tribbles homolog 2 (TRB-2)	Bos taurus (Bovine)	negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-10 production [GO:0032693]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of MAP kinase activity [GO:0043405]	mitogen-activated protein kinase kinase binding [GO:0031434]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005856; GO:0031434; GO:0031625; GO:0032436; GO:0032693; GO:0043405; GO:0045599; GO:0055106; GO:0061629
GN008824	GN008824.1	A1Z7A6	63.3	60	78	1155	5.51e-19	82.4	ASAP_DROME	ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein	Drosophila melanogaster (Fruit fly)	compound eye morphogenesis [GO:0001745]; mitotic cleavage furrow ingression [GO:1990386]; positive regulation of protein localization [GO:1903829]; regulation of Golgi organization [GO:1903358]	GTPase activator activity [GO:0005096]; phosphatidylinositol phosphate binding [GO:1901981]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; microvillus [GO:0005902]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0001745; GO:0005096; GO:0005634; GO:0005737; GO:0005886; GO:0005902; GO:0045177; GO:1901981; GO:1903358; GO:1903829; GO:1990386
GN008832	GN008832.1	O42412	44.0	116	125	258	8.81e-28	105	IOD3_CHICK	Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase)	Gallus gallus (Chicken)	thyroid hormone catabolic process [GO:0042404]; thyroid hormone metabolic process [GO:0042403]	thyroxine 5'-deiodinase activity [GO:0004800]; thyroxine 5-deiodinase activity [GO:0033798]	endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	GO:0004800; GO:0005886; GO:0010008; GO:0033798; GO:0042403; GO:0042404
GN008833	GN008833.1	Q0P5F3	80.1	146	159	197	4.01e-78	233	LIN7C_BOVIN	Protein lin-7 homolog C (Lin-7C)	Bos taurus (Bovine)	neurotransmitter secretion [GO:0007269]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; synaptic vesicle transport [GO:0048489]	protein-macromolecule adaptor activity [GO:0030674]	basolateral plasma membrane [GO:0016323]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; MPP7-DLG1-LIN7 complex [GO:0097025]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; synapse [GO:0045202]	GO:0005911; GO:0005923; GO:0007269; GO:0008582; GO:0016323; GO:0030674; GO:0045202; GO:0048489; GO:0097025; GO:0098793; GO:0098839
GN008838	GN008838.1	P28166	26.3	824	1322	1054	7.87e-34	145	ZFH1_DROME	Zinc finger protein 1 (Zinc finger homeodomain protein 1)	Drosophila melanogaster (Fruit fly)	axonal fasciculation [GO:0007413]; central nervous system development [GO:0007417]; epithelial to mesenchymal transition [GO:0001837]; garland nephrocyte differentiation [GO:0061321]; germ cell migration [GO:0008354]; hemocyte development [GO:0007516]; lymph gland development [GO:0048542]; mesoderm development [GO:0007498]; motor neuron axon guidance [GO:0008045]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000122; GO:0000977; GO:0000978; GO:0000981; GO:0001837; GO:0005634; GO:0006357; GO:0007399; GO:0007413; GO:0007417; GO:0007498; GO:0007516; GO:0008045; GO:0008354; GO:0035019; GO:0046716; GO:0048103; GO:0048542; GO:0051148; GO:0061321
GN008840	GN008840.1	Q5SUD9	23.2	302	812	708	3.28e-12	73.9	BBS12_MOUSE	Chaperonin-containing T-complex member BBS12 (Bardet-Biedl syndrome 12 protein homolog)	Mus musculus (Mouse)	chaperone-mediated protein complex assembly [GO:0051131]; eating behavior [GO:0042755]; intraciliary transport [GO:0042073]; negative regulation of fat cell differentiation [GO:0045599]; photoreceptor cell maintenance [GO:0045494]	ATP binding [GO:0005524]	cilium [GO:0005929]	GO:0005524; GO:0005929; GO:0042073; GO:0042755; GO:0045494; GO:0045599; GO:0051131
GN008841	GN008841.1	Q91YN5	56.8	516	510	522	4.92e-202	574	UAP1_MOUSE	UDP-N-acetylhexosamine pyrophosphorylase (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; positive regulation of type I interferon production [GO:0032481]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047]	carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; protein serine pyrophosphorylase activity [GO:0141090]; UDP-N-acetylgalactosamine diphosphorylase activity [GO:0052630]; UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0003977; GO:0005654; GO:0005829; GO:0005886; GO:0006047; GO:0006048; GO:0030246; GO:0032481; GO:0042802; GO:0052630; GO:0140374; GO:0141090
GN008844	GN008844.1	Q19673	31.8	305	687	693	1.68e-29	128	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN008845	GN008845.1	P86854	30.1	136	182	156	1.14e-15	73.6	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN008846	GN008846.1	P86854	31.2	141	183	156	1.21e-19	84.0	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN008847	GN008847.1	P86854	30.1	136	182	156	1.14e-15	73.6	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN008849	GN008849.1	P86854	30.1	136	209	156	1.11e-15	74.3	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN008851	GN008851.1	P86854	33.6	131	183	156	1.71e-19	83.6	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN008852	GN008852.1	P86854	31.2	141	206	156	1.21e-18	82.0	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN008853	GN008853.1	P86854	30.1	136	182	156	6.19e-15	71.6	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN008859	GN008859.1	Q9VZW5	24.4	324	337	549	1.56e-15	80.9	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN008868	GN008868.1	Q9JLB4	26.9	554	574	3623	4.87e-44	172	CUBN_MOUSE	Cubilin (Intrinsic factor-cobalamin receptor)	Mus musculus (Mouse)	cobalamin catabolic process [GO:0042366]; cobalamin transport [GO:0015889]; endocytic hemoglobin import into cell [GO:0020028]; in utero embryonic development [GO:0001701]; lipoprotein transport [GO:0042953]; receptor-mediated endocytosis [GO:0006898]; response to bacterium [GO:0009617]; response to nutrient [GO:0007584]	calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; hemoglobin binding [GO:0030492]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; signaling receptor activity [GO:0038023]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; coated vesicle [GO:0030135]; cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; signaling receptor complex [GO:0043235]	GO:0001701; GO:0005509; GO:0005737; GO:0005765; GO:0005768; GO:0005783; GO:0005794; GO:0005798; GO:0005886; GO:0005903; GO:0005905; GO:0006898; GO:0007584; GO:0009617; GO:0010008; GO:0015889; GO:0016020; GO:0016324; GO:0020028; GO:0030135; GO:0030139; GO:0030492; GO:0030666; GO:0031526; GO:0031528; GO:0032991; GO:0038023; GO:0038024; GO:0042366; GO:0042802; GO:0042803; GO:0042953; GO:0043202; GO:0043235; GO:0045177; GO:0070062
GN008870	GN008870.1	F1RWC3	32.8	235	339	3625	6.87e-26	112	CUBN_PIG	Cubilin (Intrinsic factor-cobalamin receptor)	Sus scrofa (Pig)		calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]	apical plasma membrane [GO:0016324]; endosome [GO:0005768]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	GO:0004252; GO:0005509; GO:0005765; GO:0005768; GO:0005886; GO:0016324
GN008871	GN008871.1	Q5RKH6	34.2	699	641	666	1.94e-74	254	OS9_RAT	Protein OS-9	Rattus norvegicus (Rat)	endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein retention in ER lumen [GO:0006621]; protein targeting [GO:0006605]; protein ubiquitination [GO:0016567]; response to endoplasmic reticulum stress [GO:0034976]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511]	glycosylation-dependent protein binding [GO:0140032]; protease binding [GO:0002020]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; Hrd1p ubiquitin ligase complex [GO:0000836]	GO:0000836; GO:0002020; GO:0005783; GO:0005788; GO:0006511; GO:0006605; GO:0006621; GO:0016567; GO:0030968; GO:0030970; GO:0034976; GO:0036503; GO:0140032; GO:1904153
GN008872	GN008872.1	Q32PP1	42.9	154	424	395	1.28e-23	105	MRNIP_DANRE	MRN complex-interacting protein (MRN-interacting protein)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA damage response [GO:0006974]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein kinase activity [GO:0045860]; protein localization to chromatin [GO:0071168]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; response to ionizing radiation [GO:0010212]	chromatin binding [GO:0003682]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003682; GO:0005634; GO:0005654; GO:0006974; GO:0007095; GO:0010212; GO:0045860; GO:0071168; GO:1905168; GO:2001032
GN008873	GN008873.1	P14198	47.0	100	120	678	1.53e-16	77.4	AAC4_DICDI	AAC-rich mRNA AAC4 protein	Dictyostelium discoideum (Social amoeba)			membrane [GO:0016020]	GO:0016020
GN008874	GN008874.1	Q6DE37	51.7	315	374	423	1.46e-110	332	GXLT2_XENLA	Glucoside xylosyltransferase 2 (EC 2.4.2.42) (Glycosyltransferase 8 domain-containing protein 4)	Xenopus laevis (African clawed frog)	protein O-linked glycosylation via glucose [GO:0180059]; protein O-linked glycosylation via N-acetyl-galactosamine [GO:0016266]	UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity [GO:0140563]; UDP-xylosyltransferase activity [GO:0035252]	membrane [GO:0016020]	GO:0016020; GO:0016266; GO:0035252; GO:0140563; GO:0180059
GN008875	GN008875.1	Q6DJM6	33.3	267	502	464	4.13e-30	125	INT12_XENLA	Integrator complex subunit 12 (Int12)	Xenopus laevis (African clawed frog)	RNA polymerase II transcription initiation surveillance [GO:0160240]; snRNA 3'-end processing [GO:0034472]		INTAC complex [GO:0160232]; integrator complex [GO:0032039]; nucleus [GO:0005634]	GO:0005634; GO:0032039; GO:0034472; GO:0160232; GO:0160240
GN008876	GN008876.1	Q8K2P6	33.3	99	154	157	3.24e-14	68.9	RFESD_MOUSE	Rieske domain-containing protein	Mus musculus (Mouse)		2 iron, 2 sulfur cluster binding [GO:0051537]		GO:0051537
GN008877	GN008877.1	Q9NTG7	50.0	284	822	399	3.20e-88	288	SIR3_HUMAN	NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 2.3.1.286) (NAD-dependent protein delactylase sirtuin-3) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3)	Homo sapiens (Human)	aerobic respiration [GO:0009060]; cellular response to stress [GO:0033554]; mitochondrial fusion [GO:0008053]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of catalase activity [GO:1902553]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of superoxide dismutase activity [GO:1901671]; protein deacetylation [GO:0006476]	enzyme binding [GO:0019899]; histone deacetylase activity, NAD-dependent [GO:0017136]; NAD+ binding [GO:0070403]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; NAD-dependent protein lysine delactylase activity [GO:0141208]; protein lysine deacetylase activity [GO:0033558]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	GO:0005654; GO:0005739; GO:0005759; GO:0006476; GO:0008053; GO:0008270; GO:0009060; GO:0017136; GO:0019899; GO:0032024; GO:0032991; GO:0033554; GO:0033558; GO:0034979; GO:0034983; GO:0043565; GO:0070373; GO:0070403; GO:0141208; GO:1901671; GO:1902553; GO:1903862; GO:2000304; GO:2000378
GN008878	GN008878.1	Q8AVR2	52.7	182	233	215	1.41e-52	172	FGOP2_XENLA	FGFR1 oncogene partner 2 homolog	Xenopus laevis (African clawed frog)	response to wounding [GO:0009611]		cytoplasm [GO:0005737]	GO:0005737; GO:0009611
GN008880	GN008880.1	Q922R8	60.0	370	371	440	4.82e-158	454	PDIA6_MOUSE	Protein disulfide-isomerase A6 (EC 5.3.4.1) (Thioredoxin domain-containing protein 7)	Mus musculus (Mouse)	IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]	protein disulfide isomerase activity [GO:0003756]; protein-disulfide reductase activity [GO:0015035]	centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular region [GO:0005576]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]	GO:0003756; GO:0005576; GO:0005783; GO:0005788; GO:0005790; GO:0005793; GO:0005886; GO:0005929; GO:0015035; GO:0030168; GO:0034451; GO:0034663; GO:0036064; GO:0036498; GO:0042470; GO:0070527; GO:1903895
GN008881	GN008881.1	Q8VCM4	42.9	289	378	373	2.83e-79	251	LIPT_MOUSE	Lipoyl amidotransferase LIPT1, mitochondrial (EC 2.3.1.200) (Lipoate biosynthesis protein) (Lipoate-protein ligase) (Lipoyl ligase) (Lipoyltransferase 1) (EC 2.3.1.-)	Mus musculus (Mouse)	protein lipoylation [GO:0009249]	acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; lipoyltransferase activity [GO:0017118]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0005737; GO:0005739; GO:0009249; GO:0016747; GO:0017118
GN008886	GN008886.1	Q5T2R2	55.5	346	394	415	9.51e-123	364	DPS1_HUMAN	All trans-polyprenyl-diphosphate synthase PDSS1 (All-trans-decaprenyl-diphosphate synthase subunit 1) (EC 2.5.1.91) (Decaprenyl pyrophosphate synthase subunit 1) (Decaprenyl-diphosphate synthase subunit 1) (Solanesyl-diphosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1)	Homo sapiens (Human)	isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744]	all-trans-decaprenyl-diphosphate synthase activity [GO:0097269]; all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity [GO:0052923]	heterotetrameric polyprenyl diphosphate synthase complex [GO:0032478]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; polyprenyl diphosphate synthase complex [GO:0032476]	GO:0005739; GO:0005759; GO:0006744; GO:0008299; GO:0032476; GO:0032478; GO:0052923; GO:0097269
GN008887	GN008887.1	O75884	61.0	177	180	186	2.85e-81	241	RBBP9_HUMAN	Serine hydrolase RBBP9 (EC 3.1.-.-) (B5T-overexpressed gene protein) (Protein BOG) (Retinoblastoma-binding protein 10) (RBBP-10) (Retinoblastoma-binding protein 9) (RBBP-9)	Homo sapiens (Human)	xenobiotic metabolic process [GO:0006805]	serine hydrolase activity [GO:0017171]	nucleoplasm [GO:0005654]	GO:0005654; GO:0006805; GO:0017171
GN008888	GN008888.1	Q8MIB8	46.2	65	1110	241	2.03e-13	74.7	TF2LX_PONPY	Homeobox protein TGIF2LX (TGF-beta-induced transcription factor 2-like protein) (TGFB-induced factor 2-like protein, X-linked) (TGIF-like on the X)	Pongo pygmaeus (Bornean orangutan)	regulation of DNA-templated transcription [GO:0006355]	DNA binding [GO:0003677]	nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0006355
GN008893	GN008893.1	Q0IIF6	66.1	177	180	201	3.49e-83	247	FAIM1_BOVIN	Fas apoptotic inhibitory molecule 1	Bos taurus (Bovine)	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]		cytoplasm [GO:0005737]	GO:0005737; GO:1902042
GN008898	GN008898.1	Q8N0N3	40.1	344	448	366	1.40e-71	233	BGBP_PENMO	Beta-1,3-glucan-binding protein (GBP)	Penaeus monodon (Giant tiger prawn)	carbohydrate metabolic process [GO:0005975]; innate immune response [GO:0045087]	(1->3)-beta-D-glucan binding [GO:0001872]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	extracellular region [GO:0005576]	GO:0001872; GO:0004553; GO:0005576; GO:0005975; GO:0045087
GN008901	GN008901.1	Q6YHK3	24.4	704	725	1445	1.38e-44	176	CD109_HUMAN	CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)	Homo sapiens (Human)	negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]	endopeptidase inhibitor activity [GO:0004866]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	GO:0004866; GO:0005576; GO:0005886; GO:0009986; GO:0030512; GO:0031092; GO:0061045
GN008903	GN008903.1	Q6YHK3	41.6	293	328	1445	1.55e-68	235	CD109_HUMAN	CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)	Homo sapiens (Human)	negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]	endopeptidase inhibitor activity [GO:0004866]	cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]	GO:0004866; GO:0005576; GO:0005886; GO:0009986; GO:0030512; GO:0031092; GO:0061045
GN008904	GN008904.1	A8K2U0	32.8	274	1195	1454	4.51e-24	114	A2ML1_HUMAN	Alpha-2-macroglobulin-like protein 1 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9)	Homo sapiens (Human)	regulation of endopeptidase activity [GO:0052548]	endopeptidase inhibitor activity [GO:0004866]; peptidase inhibitor activity [GO:0030414]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	GO:0004866; GO:0005576; GO:0030414; GO:0052548; GO:0070062
GN008905	GN008905.1	Q8BP00	33.4	590	592	598	5.76e-92	298	IQCB1_MOUSE	IQ calmodulin-binding motif-containing protein 1	Mus musculus (Mouse)	cilium assembly [GO:0060271]; cytosolic ciliogenesis [GO:0061824]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]	BBSome binding [GO:0062063]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; protein-macromolecule adaptor activity [GO:0030674]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]	GO:0001750; GO:0005516; GO:0005813; GO:0005929; GO:0019899; GO:0030674; GO:0032391; GO:0036064; GO:0045494; GO:0048496; GO:0060271; GO:0061824; GO:0062063
GN008914	GN008914.1	Q59RQ0	25.8	256	1115	906	5.50e-09	64.3	PIF1_CANAL	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)	double-strand break repair via break-induced replication [GO:0000727]; negative regulation of telomere maintenance via telomerase [GO:0032211]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; translesion synthesis [GO:0019985]	3'-5' exonuclease activity [GO:0008408]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; centromeric DNA binding [GO:0019237]; DNA helicase activity [GO:0003678]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex unwinding activity [GO:0160225]; single-stranded DNA binding [GO:0003697]; telomerase inhibitor activity [GO:0010521]; telomeric repeat DNA binding [GO:0042162]	mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; site of double-strand break [GO:0035861]	GO:0000722; GO:0000723; GO:0000727; GO:0003678; GO:0003697; GO:0005524; GO:0005739; GO:0008408; GO:0010521; GO:0016887; GO:0019237; GO:0019985; GO:0031966; GO:0032211; GO:0035861; GO:0042162; GO:0043139; GO:0043596; GO:0051880; GO:0071932; GO:0160225
GN008915	GN008915.1	P17427	69.2	948	910	938	0.0	1226	AP2A2_MOUSE	AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)	Mus musculus (Mouse)	clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; postsynaptic neurotransmitter receptor internalization [GO:0098884]; regulation of hematopoietic stem cell differentiation [GO:1902036]; synaptic vesicle endocytosis [GO:0048488]; vesicle-mediated transport [GO:0016192]	clathrin-cargo adaptor activity [GO:0035615]; disordered domain specific binding [GO:0097718]; kinase binding [GO:0019900]; phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein serine/threonine kinase binding [GO:0120283]; protein-containing complex binding [GO:0044877]	AP-2 adaptor complex [GO:0030122]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; membrane coat [GO:0030117]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; secretory granule [GO:0030141]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]	GO:0005886; GO:0006886; GO:0008021; GO:0009898; GO:0016192; GO:0019900; GO:0019901; GO:0019904; GO:0030117; GO:0030122; GO:0030141; GO:0031410; GO:0035091; GO:0035615; GO:0044877; GO:0045202; GO:0048488; GO:0072583; GO:0097718; GO:0098794; GO:0098884; GO:0120283; GO:1902036
GN008916	GN008916.1	M0R2J8	29.6	1776	1892	1783	8.44e-216	694	DCDC1_HUMAN	Doublecortin domain-containing protein 1 (Doublecortin domain-containing 5 protein)	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]; regulation of mitotic cytokinesis [GO:1902412]	microtubule binding [GO:0008017]	Flemming body [GO:0090543]; midbody [GO:0030496]; mitotic spindle [GO:0072686]	GO:0008017; GO:0030496; GO:0035556; GO:0072686; GO:0090543; GO:1902412
GN008918	GN008918.1	Q9UKZ1	64.9	450	454	510	1.15e-197	560	CNO11_HUMAN	CCR4-NOT transcription complex subunit 11	Homo sapiens (Human)	nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]		CCR4-NOT complex [GO:0030014]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000289; GO:0005634; GO:0005829; GO:0030014
GN008920	GN008920.1	Q9Z0W3	38.7	943	929	1402	2.55e-178	557	NU160_MOUSE	Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Gene trap locus 1-13 protein) (GTL-13) (Nucleoporin Nup160)	Mus musculus (Mouse)	mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nucleocytoplasmic transport [GO:0006913]	structural constituent of nuclear pore [GO:0017056]	nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]	GO:0005635; GO:0005643; GO:0006406; GO:0006913; GO:0017056; GO:0031080; GO:0072006
GN008921	GN008921.1	O75973	32.2	115	259	258	2.56e-11	65.5	C1QRF_HUMAN	C1q-related factor (C1q and tumor necrosis factor-related protein 14) (C1q/TNF-related protein 14) (Complement component 1 Q subcomponent-like 1)	Homo sapiens (Human)	locomotory behavior [GO:0007626]; maintenance of synapse structure [GO:0099558]; regulation of synapse pruning [GO:1905806]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	signaling receptor binding [GO:0005102]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; climbing fiber [GO:0044301]; cytoplasm [GO:0005737]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0005102; GO:0005737; GO:0007626; GO:0043083; GO:0044301; GO:0045202; GO:0098793; GO:0099550; GO:0099558; GO:0150053; GO:1905806
GN008923	GN008923.1	O75973	30.4	112	607	258	7.68e-09	60.5	C1QRF_HUMAN	C1q-related factor (C1q and tumor necrosis factor-related protein 14) (C1q/TNF-related protein 14) (Complement component 1 Q subcomponent-like 1)	Homo sapiens (Human)	locomotory behavior [GO:0007626]; maintenance of synapse structure [GO:0099558]; regulation of synapse pruning [GO:1905806]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	signaling receptor binding [GO:0005102]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; climbing fiber [GO:0044301]; cytoplasm [GO:0005737]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0005102; GO:0005737; GO:0007626; GO:0043083; GO:0044301; GO:0045202; GO:0098793; GO:0099550; GO:0099558; GO:0150053; GO:1905806
GN008926	GN008926.1	Q8BM89	38.9	542	546	598	1.77e-120	370	ARSJ_MOUSE	Arylsulfatase J (ASJ) (EC 3.1.6.-)	Mus musculus (Mouse)		sulfuric ester hydrolase activity [GO:0008484]	actin cytoskeleton [GO:0015629]; extracellular region [GO:0005576]	GO:0005576; GO:0008484; GO:0015629
GN008928	GN008928.1	P49282	55.5	472	525	568	5.59e-163	477	NRAM2_MOUSE	Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2)	Mus musculus (Mouse)	cadmium ion transmembrane transport [GO:0070574]; cellular response to oxidative stress [GO:0034599]; cobalt ion transport [GO:0006824]; copper ion import across plasma membrane [GO:0098705]; copper ion transport [GO:0006825]; dendrite morphogenesis [GO:0048813]; erythrocyte development [GO:0048821]; heme biosynthetic process [GO:0006783]; intracellular iron ion homeostasis [GO:0006879]; intracellular manganese ion homeostasis [GO:0030026]; iron import into cell [GO:0033212]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]; lead ion transport [GO:0015692]; learning or memory [GO:0007611]; manganese ion transport [GO:0006828]; multicellular organismal-level iron ion homeostasis [GO:0060586]; nickel cation transport [GO:0015675]; porphyrin-containing compound biosynthetic process [GO:0006779]; porphyrin-containing compound metabolic process [GO:0006778]; proton transmembrane transport [GO:1902600]; response to iron ion [GO:0010039]; response to manganese ion [GO:0010042]; transition metal ion transport [GO:0000041]; vanadium ion transport [GO:0015676]	cadmium ion binding [GO:0046870]; cadmium ion transmembrane transporter activity [GO:0015086]; cobalt ion binding [GO:0050897]; cobalt ion transmembrane transporter activity [GO:0015087]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; ferrous iron transmembrane transporter activity [GO:0015093]; iron ion binding [GO:0005506]; iron ion transmembrane transporter activity [GO:0005381]; lead ion transmembrane transporter activity [GO:0015094]; manganese ion binding [GO:0030145]; manganese ion transmembrane transporter activity [GO:0005384]; nickel cation binding [GO:0016151]; nickel cation transmembrane transporter activity [GO:0015099]; proton transmembrane transporter activity [GO:0015078]; retromer complex binding [GO:1905394]; solute:proton symporter activity [GO:0015295]; transition metal ion transmembrane transporter activity [GO:0046915]; transmembrane transporter activity [GO:0022857]; vanadium ion transmembrane transporter activity [GO:0015100]; zinc ion binding [GO:0008270]; zinc ion transmembrane transporter activity [GO:0005385]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basal part of cell [GO:0045178]; brush border [GO:0005903]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular vesicle [GO:1903561]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; paraferritin complex [GO:0070826]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773]	GO:0000041; GO:0005375; GO:0005381; GO:0005384; GO:0005385; GO:0005506; GO:0005507; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005764; GO:0005765; GO:0005768; GO:0005769; GO:0005770; GO:0005773; GO:0005802; GO:0005886; GO:0005903; GO:0006778; GO:0006779; GO:0006783; GO:0006824; GO:0006825; GO:0006826; GO:0006828; GO:0006879; GO:0007611; GO:0008270; GO:0009986; GO:0010008; GO:0010039; GO:0010042; GO:0012505; GO:0015078; GO:0015086; GO:0015087; GO:0015093; GO:0015094; GO:0015099; GO:0015100; GO:0015295; GO:0015675; GO:0015676; GO:0015692; GO:0016151; GO:0016324; GO:0022857; GO:0030026; GO:0030145; GO:0031410; GO:0031526; GO:0031901; GO:0031902; GO:0033212; GO:0034599; GO:0034755; GO:0045177; GO:0045178; GO:0046870; GO:0046915; GO:0048471; GO:0048813; GO:0048821; GO:0050897; GO:0055037; GO:0055038; GO:0060586; GO:0070574; GO:0070826; GO:0098705; GO:1902600; GO:1903561; GO:1905394
GN008929	GN008929.1	O43301	31.2	317	321	675	6.02e-37	143	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN008930	GN008930.1	Q96MM6	42.2	173	206	686	1.55e-32	126	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN008931	GN008931.1	F1LTE0	56.4	1116	2050	1992	1.04e-235	757	TANC2_RAT	Protein TANC2	Rattus norvegicus (Rat)	dense core granule cytoskeletal transport [GO:0099519]; in utero embryonic development [GO:0001701]; regulation of dendritic spine development [GO:0060998]; regulation of dendritic spine morphogenesis [GO:0061001]	structural constituent of postsynaptic density [GO:0098919]	axon [GO:0030424]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]	GO:0001701; GO:0014069; GO:0030424; GO:0043197; GO:0060998; GO:0061001; GO:0098919; GO:0098978; GO:0099092; GO:0099519
GN008933	GN008933.1	Q6P3W7	49.3	422	393	929	1.95e-140	426	SCYL2_HUMAN	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa)	Homo sapiens (Human)	brain development [GO:0007420]; clathrin-dependent endocytosis [GO:0072583]; endosome to lysosome transport [GO:0008333]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; pyramidal neuron development [GO:0021860]; receptor internalization [GO:0031623]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; signaling receptor binding [GO:0005102]	clathrin-coated vesicle [GO:0030136]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]	GO:0004672; GO:0005102; GO:0005524; GO:0005794; GO:0007420; GO:0008333; GO:0010008; GO:0021860; GO:0030136; GO:0031623; GO:0072583; GO:0090090
GN008934	GN008934.1	Q4R9E0	25.3	667	746	608	9.49e-35	144	TECT3_MACFA	Tectonic-3	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	cilium assembly [GO:0060271]; smoothened signaling pathway [GO:0007224]		membrane [GO:0016020]	GO:0007224; GO:0016020; GO:0060271
GN008935	GN008935.1	Q78WZ7	40.0	145	257	330	1.02e-17	84.3	RPA43_MOUSE	DNA-directed RNA polymerase I subunit RPA43 (DNA-directed RNA polymerase I subunit F) (Twist neighbor protein)	Mus musculus (Mouse)	cellular response to leukemia inhibitory factor [GO:1990830]; DNA-templated transcription initiation [GO:0006352]; transcription elongation by RNA polymerase I [GO:0006362]		fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]	GO:0001650; GO:0005654; GO:0005736; GO:0006352; GO:0006362; GO:1990830
GN008936	GN008936.1	A0A0E0RTV6	28.0	475	532	565	1.25e-35	143	ZEB1_GIBZE	FAD-linked oxidoreductase ZEB1 (EC 1.-.-.-) (Zearalenone biosynthesis protein 1)	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)	zearalenone biosynthetic process [GO:0106150]	FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]		GO:0016491; GO:0071949; GO:0106150
GN008937	GN008937.1	B3EWY9	27.5	810	2276	1594	5.17e-66	252	MLP_ACRMI	Mucin-like protein	Acropora millepora (Staghorn coral) (Heteropora millepora)	cell-matrix adhesion [GO:0007160]	calcium ion binding [GO:0005509]	membrane [GO:0016020]	GO:0005509; GO:0007160; GO:0016020
GN008938	GN008938.1	Q96DM1	27.1	199	424	585	6.71e-21	98.6	PGBD4_HUMAN	PiggyBac transposable element-derived protein 4	Homo sapiens (Human)				
GN008939	GN008939.1	E1BYJ2	38.1	381	475	1337	1.21e-50	189	MSH6_CHICK	DNA mismatch repair protein Msh6	Gallus gallus (Chicken)	mismatch repair [GO:0006298]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of DNA endoreduplication [GO:0032876]; positive regulation of B cell proliferation [GO:0030890]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; mismatched DNA binding [GO:0030983]	MutSalpha complex [GO:0032301]; nucleus [GO:0005634]	GO:0005524; GO:0005634; GO:0006298; GO:0007095; GO:0030890; GO:0030983; GO:0032301; GO:0032876; GO:0140664
GN008940	GN008940.1	Q4QQW3	65.2	325	325	467	9.17e-150	432	HOT_RAT	Hydroxyacid-oxoacid transhydrogenase, mitochondrial (HOT) (EC 1.1.99.24) (Alcohol dehydrogenase iron-containing protein 1) (ADHFe1)	Rattus norvegicus (Rat)	ketone body catabolic process [GO:0046952]	alcohol dehydrogenase (NAD+) activity [GO:0004022]; hydroxyacid-oxoacid transhydrogenase activity [GO:0047988]; metal ion binding [GO:0046872]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004022; GO:0005739; GO:0005759; GO:0046872; GO:0046952; GO:0047988
GN008942	GN008942.1	O01802	59.2	245	245	244	1.04e-99	293	RL7_CAEEL	Large ribosomal subunit protein uL30 (60S ribosomal protein L7)	Caenorhabditis elegans	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]	RNA binding [GO:0003723]	cytosolic large ribosomal subunit [GO:0022625]	GO:0000463; GO:0003723; GO:0022625
GN008943	GN008943.1	O08848	30.9	418	445	538	1.52e-50	182	RO60_MOUSE	RNA-binding protein Ro60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2)	Mus musculus (Mouse)	cellular response to interferon-alpha [GO:0035457]; cilium assembly [GO:0060271]; immune system development [GO:0002520]; regulation of gene expression [GO:0010468]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]	misfolded RNA binding [GO:0034336]; RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0005829; GO:0007224; GO:0009411; GO:0010468; GO:0030620; GO:0034336; GO:0035457; GO:0060271; GO:1990904
GN008944	GN008944.1	Q9GZR5	55.6	275	280	314	3.39e-109	321	ELOV4_HUMAN	Very long chain fatty acid elongase 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Elongation of very long chain fatty acids protein 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4)	Homo sapiens (Human)	circadian rhythm [GO:0007623]; fatty acid biosynthetic process [GO:0006633]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; negative regulation of mini excitatory postsynaptic potential [GO:0061886]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; short-term synaptic potentiation [GO:1990926]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	fatty acid elongase activity [GO:0009922]; G protein-coupled photoreceptor activity [GO:0008020]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0006633; GO:0006636; GO:0007623; GO:0008020; GO:0009922; GO:0019367; GO:0030148; GO:0034625; GO:0034626; GO:0035338; GO:0042761; GO:0061886; GO:0097151; GO:1990926
GN008945	GN008945.1	Q9EQC4	49.8	291	289	312	7.26e-93	280	ELOV4_MOUSE	Very long chain fatty acid elongase 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Elongation of very long chain fatty acids protein 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4)	Mus musculus (Mouse)	circadian rhythm [GO:0007623]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; negative regulation of mini excitatory postsynaptic potential [GO:0061886]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; short-term synaptic potentiation [GO:1990926]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	fatty acid elongase activity [GO:0009922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0006636; GO:0007623; GO:0009922; GO:0019367; GO:0030148; GO:0034625; GO:0034626; GO:0035338; GO:0042761; GO:0061886; GO:0097151; GO:1990926
GN008957	GN008957.1	Q6UX65	31.6	247	286	266	1.89e-30	118	DRAM2_HUMAN	DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77)	Homo sapiens (Human)	photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601]		apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; photoreceptor inner segment [GO:0001917]	GO:0001917; GO:0005737; GO:0005764; GO:0005765; GO:0005794; GO:0007601; GO:0010506; GO:0016324; GO:0045494
GN008968	GN008968.1	P09479	33.8	133	164	456	5.30e-18	83.2	ACHA_CHICK	Acetylcholine receptor subunit alpha	Gallus gallus (Chicken)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; skeletal muscle contraction [GO:0003009]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]	GO:0003009; GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0098793; GO:0099171
GN008970	GN008970.1	Q53GQ0	49.8	303	321	312	1.07e-95	288	DHB12_HUMAN	Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1)	Homo sapiens (Human)	androgen biosynthetic process [GO:0006702]; estrogen biosynthetic process [GO:0006703]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]	acetoacetyl-CoA reductase activity [GO:0018454]; collagen binding [GO:0005518]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; testosterone dehydrogenase (NADP+) activity [GO:0047045]; very-long-chain 3-oxoacyl-CoA reductase activity [GO:0141040]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; fatty acid elongase complex [GO:0009923]	GO:0001968; GO:0004303; GO:0005518; GO:0005783; GO:0005789; GO:0006702; GO:0006703; GO:0008201; GO:0009923; GO:0018454; GO:0019367; GO:0031012; GO:0035338; GO:0047045; GO:0141040
GN008976	GN008976.1	P49894	48.1	108	120	244	8.45e-27	102	IOD1_CANLF	Type I iodothyronine deiodinase (EC 1.21.99.3) (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase)	Canis lupus familiaris (Dog) (Canis familiaris)	amino acid metabolic process [GO:0006520]; thyroid hormone catabolic process [GO:0042404]; thyroid hormone metabolic process [GO:0042403]	thyroxine 5'-deiodinase activity [GO:0004800]; thyroxine 5-deiodinase activity [GO:0033798]	basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0004800; GO:0005789; GO:0005886; GO:0006520; GO:0016323; GO:0033798; GO:0042403; GO:0042404
GN008980	GN008980.1	P0DUE1	53.9	128	163	415	1.76e-33	125	STING_MAGGI	Stimulator of interferon genes protein (TIR-STING) (Probable NAD(+) hydrolase) (EC 3.2.2.6)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	activation of innate immune response [GO:0002218]; autophagosome assembly [GO:0000045]; innate immune response [GO:0045087]; positive regulation of macroautophagy [GO:0016239]; positive regulation of type I interferon production [GO:0032481]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; NAD+ nucleosidase activity, cyclic ADP-ribose generating [GO:0061809]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]	GO:0000045; GO:0002218; GO:0005776; GO:0005789; GO:0007165; GO:0016239; GO:0032481; GO:0035438; GO:0045087; GO:0061507; GO:0061709; GO:0061809
GN008981	GN008981.1	P0DUE1	66.7	63	64	415	1.56e-23	94.0	STING_MAGGI	Stimulator of interferon genes protein (TIR-STING) (Probable NAD(+) hydrolase) (EC 3.2.2.6)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	activation of innate immune response [GO:0002218]; autophagosome assembly [GO:0000045]; innate immune response [GO:0045087]; positive regulation of macroautophagy [GO:0016239]; positive regulation of type I interferon production [GO:0032481]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; NAD+ nucleosidase activity, cyclic ADP-ribose generating [GO:0061809]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]	GO:0000045; GO:0002218; GO:0005776; GO:0005789; GO:0007165; GO:0016239; GO:0032481; GO:0035438; GO:0045087; GO:0061507; GO:0061709; GO:0061809
GN008982	GN008982.1	Q8BLA8	23.2	314	1108	1125	3.90e-10	68.2	TRPA1_MOUSE	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Wasabi receptor)	Mus musculus (Mouse)	calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to caffeine [GO:0071313]; cellular response to carbon dioxide [GO:0071244]; cellular response to cold [GO:0070417]; cellular response to food [GO:0071240]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to toxic substance [GO:0097237]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of monoatomic anion transport [GO:1903793]; protein homotetramerization [GO:0051289]; regulation of blood circulation [GO:1903522]; regulation of neuronal action potential [GO:0098908]; response to cold [GO:0009409]; response to hydrogen peroxide [GO:0042542]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]; ureteric peristalsis [GO:0072105]; urinary bladder smooth muscle contraction [GO:0014832]; vasodilation [GO:0042311]	calcium channel activity [GO:0005262]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; monoatomic ion channel activity [GO:0005216]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]; temperature-gated cation channel activity [GO:0097604]; voltage-gated calcium channel activity [GO:0005245]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]	GO:0005216; GO:0005245; GO:0005262; GO:0005886; GO:0006816; GO:0006874; GO:0007166; GO:0009409; GO:0009410; GO:0014832; GO:0015267; GO:0015278; GO:0016020; GO:0016324; GO:0019233; GO:0030424; GO:0032421; GO:0034605; GO:0035774; GO:0042311; GO:0042542; GO:0042802; GO:0048265; GO:0050955; GO:0050966; GO:0050968; GO:0050974; GO:0051289; GO:0070301; GO:0070417; GO:0070588; GO:0071240; GO:0071244; GO:0071313; GO:0072105; GO:0097237; GO:0097553; GO:0097604; GO:0098908; GO:1903522; GO:1903793; GO:1990760
GN008987	GN008987.1	Q8HYL8	48.7	663	666	661	9.98e-222	636	ACOX1_PHACI	Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase)	Phascolarctos cinereus (Koala)	fatty acid catabolic process [GO:0009062]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; hydrogen peroxide biosynthetic process [GO:0050665]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; prostaglandin metabolic process [GO:0006693]; very long-chain fatty acid beta-oxidation [GO:0140493]	acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; long-chain fatty acyl-CoA oxidase activity [GO:0120524]; medium-chain fatty acyl-CoA oxidase activity [GO:0120523]; protein homodimerization activity [GO:0042803]; very-long-chain fatty acyl-CoA oxidase activity [GO:0044535]	peroxisome [GO:0005777]	GO:0003997; GO:0005504; GO:0005777; GO:0006091; GO:0006629; GO:0006693; GO:0009062; GO:0019395; GO:0042803; GO:0044535; GO:0050665; GO:0055088; GO:0071949; GO:0120523; GO:0120524; GO:0140493
GN008988	GN008988.1	Q0V9A9	54.9	277	296	289	3.11e-103	306	LACB2_XENTR	Endoribonuclease LACTB2 (Beta-lactamase-like protein 2) (EC 3.1.27.-)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		RNA endonuclease activity [GO:0004521]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]	GO:0003727; GO:0004521; GO:0005759; GO:0008270
GN008990	GN008990.1	Q6YP21	51.8	301	326	454	3.93e-99	302	KAT3_HUMAN	Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III)	Homo sapiens (Human)		cysteine-S-conjugate beta-lyase activity [GO:0047804]; L-kynurenine:2-oxoglutarate transaminase activity [GO:0016212]; L-kynurenine:glyoxylate transaminase activity [GO:0047315]; pyridoxal phosphate binding [GO:0030170]; RNA binding [GO:0003723]	mitochondrion [GO:0005739]	GO:0003723; GO:0005739; GO:0016212; GO:0030170; GO:0047315; GO:0047804
GN008998	GN008998.1	P97872	49.6	393	392	533	3.59e-132	392	FMO5_MOUSE	Flavin-containing monooxygenase 5 (FMO 5) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (NADPH oxidase) (EC 1.6.3.1)	Mus musculus (Mouse)	regulation of cholesterol metabolic process [GO:0090181]; xenobiotic metabolic process [GO:0006805]	flavin adenine dinucleotide binding [GO:0050660]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADP binding [GO:0050661]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0004497; GO:0004499; GO:0005783; GO:0005789; GO:0005829; GO:0006805; GO:0016174; GO:0050660; GO:0050661; GO:0090181
GN008999	GN008999.1	Q71UH5	37.9	140	166	149	4.46e-20	84.3	CALM_GLOSP	Calmodulin (CaM)	Globisporangium splendens (Leaf rot fungus) (Pythium splendens)		calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; myosin II complex [GO:0016460]	GO:0005509; GO:0005737; GO:0016460
GN009004	GN009004.1	P83916	58.5	164	195	185	1.49e-58	184	CBX1_HUMAN	Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)	Homo sapiens (Human)	DNA damage response [GO:0006974]; heterochromatin formation [GO:0031507]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; histone H1K26me1 reader activity [GO:0160267]; histone H1K26me2 reader activity [GO:0160268]; histone H3K9me2/3 reader activity [GO:0062072]; histone methyltransferase binding [GO:1990226]	chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; heterochromatin [GO:0000792]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of DNA damage [GO:0090734]; spindle [GO:0005819]	GO:0000775; GO:0000781; GO:0000785; GO:0000792; GO:0003682; GO:0005634; GO:0005654; GO:0005721; GO:0005819; GO:0006974; GO:0016604; GO:0019899; GO:0031507; GO:0062072; GO:0090734; GO:0160267; GO:0160268; GO:1990226
GN009009	GN009009.1	O43028	39.5	504	601	550	9.25e-26	115	VAC8_SCHPO	Vacuolar protein 8	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	autophagosome assembly [GO:0000045]; nucleus-vacuole junction assembly [GO:0071562]; vacuole fusion, non-autophagic [GO:0042144]	protein-membrane adaptor activity [GO:0043495]	fungal-type vacuole membrane [GO:0000329]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000045; GO:0000139; GO:0000329; GO:0005794; GO:0042144; GO:0043495; GO:0071562
GN009013	GN009013.1	O94782	26.3	752	803	785	1.40e-44	176	UBP1_HUMAN	Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment]	Homo sapiens (Human)	monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of error-prone translesion synthesis [GO:1904333]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; protein deubiquitination [GO:0016579]; regulation of DNA repair [GO:0006282]; response to UV [GO:0009411]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peptidase complex [GO:1905368]	GO:0004197; GO:0004843; GO:0005634; GO:0005654; GO:0006282; GO:0008233; GO:0009411; GO:0016579; GO:0035520; GO:0046427; GO:1904333; GO:1905368
GN009014	GN009014.1	Q5R9X9	56.5	232	530	393	3.76e-70	233	3BP5L_PONAB	SH3 domain-binding protein 5-like (SH3BP-5-like)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	intracellular signal transduction [GO:0035556]	guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase inhibitor activity [GO:0004860]	cytoplasm [GO:0005737]	GO:0004860; GO:0005085; GO:0005737; GO:0035556
GN009016	GN009016.1	Q69ZU6	31.1	1537	1993	1645	3.78e-247	777	THS7A_MOUSE	Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]		extracellular region [GO:0005576]; plasma membrane [GO:0005886]; podocyte foot [GO:0098846]	GO:0005576; GO:0005886; GO:0030036; GO:0098846
GN009017	GN009017.1	P52168	46.4	211	680	540	2.24e-45	173	PNR_DROME	GATA-binding factor A (Protein pannier) (Transcription factor GATA-A) (dGATA-A)	Drosophila melanogaster (Fruit fly)	blastoderm segmentation [GO:0007350]; cardioblast cell fate determination [GO:0007510]; cardioblast differentiation [GO:0010002]; cardiocyte differentiation [GO:0035051]; cell fate commitment [GO:0045165]; chaeta development [GO:0022416]; embryonic heart tube development [GO:0035050]; heart contraction [GO:0060047]; imaginal disc fusion, thorax closure [GO:0046529]; lymph gland development [GO:0048542]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pericardial nephrocyte differentiation [GO:0061320]; pigment metabolic process [GO:0042440]; positive regulation of antibacterial peptide biosynthetic process [GO:0006963]; positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0005634; GO:0006963; GO:0007350; GO:0007510; GO:0008270; GO:0010002; GO:0022416; GO:0035050; GO:0035051; GO:0042440; GO:0045165; GO:0045892; GO:0045944; GO:0046529; GO:0046982; GO:0048542; GO:0060047; GO:0061320; GO:0061629
GN009020	GN009020.1	Q9NVV5	39.3	211	238	238	5.27e-51	169	AIG1_HUMAN	Androgen-induced gene 1 protein (AIG-1) (Fatty acid esters of hydroxy fatty acids hydrolase AIG1) (FAHFA hydrolase AIG1) (EC 3.1.-.-)	Homo sapiens (Human)	long-chain fatty acid catabolic process [GO:0042758]	FAHFA hydrolase activity [GO:0120573]; hydrolase activity [GO:0016787]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0016020; GO:0016787; GO:0042758; GO:0120573
GN009021	GN009021.1	Q9Y2I7	33.9	2088	1958	2098	1.55e-302	936	FYV1_HUMAN	1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1)	Homo sapiens (Human)	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process [GO:1903100]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; intracellular signal transduction [GO:0035556]; melanosome organization [GO:0032438]; neutrophil chemotaxis [GO:0030593]; peptidyl-serine autophosphorylation [GO:0036289]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; phosphatidylinositol 5-phosphate metabolic process [GO:1904562]; phosphatidylinositol biosynthetic process [GO:0006661]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; protein localization to nucleus [GO:0034504]; protein targeting to membrane [GO:0006612]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; regulation of autophagosome assembly [GO:2000785]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; retrograde transport, endosome to Golgi [GO:0042147]	1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; cholesterol binding [GO:0015485]; metal ion binding [GO:0046872]; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [GO:0043813]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; membrane raft [GO:0045121]; PAS complex [GO:0070772]; phagocytic vesicle membrane [GO:0030670]; vesicle membrane [GO:0012506]	GO:0000139; GO:0000285; GO:0004674; GO:0005524; GO:0005829; GO:0006612; GO:0006661; GO:0010008; GO:0012506; GO:0015485; GO:0016308; GO:0019065; GO:0019886; GO:0030593; GO:0030670; GO:0031410; GO:0031901; GO:0031902; GO:0032438; GO:0034504; GO:0035556; GO:0036289; GO:0042147; GO:0043813; GO:0045121; GO:0046872; GO:0052810; GO:0070772; GO:0080025; GO:0090382; GO:0090385; GO:0106310; GO:0141111; GO:1903100; GO:1903426; GO:1904562; GO:2000785
GN009022	GN009022.1	Q28HU3	27.9	190	609	303	4.93e-09	61.6	CENPO_XENTR	Centromere protein O (CENP-O)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	kinetochore assembly [GO:0051382]		Mis6-Sim4 complex [GO:0031511]; nucleus [GO:0005634]	GO:0005634; GO:0031511; GO:0051382
GN009023	GN009023.1	Q24157	34.3	207	333	325	2.56e-31	123	BRN_DROME	Beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase brn (EC 2.4.1.-) (Glycolipid-specific beta-1,3-N-Acetylglucosaminyltransferase brn) (Neurogenic secreted-signaling protein brn) (Protein brainiac) (UDP-GlcNAc:beta-Man/beta-Gal beta-1,3GlcNAc transferase) (beta3GlcNAc-transferase)	Drosophila melanogaster (Fruit fly)	arthro-series glucosylceramide biosynthetic process [GO:0140269]; border follicle cell migration [GO:0007298]; follicle cell of egg chamber development [GO:0030707]; follicle cell of egg chamber-cell adhesion [GO:0007299]; germarium-derived egg chamber formation [GO:0007293]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; insect visual primordium formation [GO:0001744]; maintenance of polarity of follicular epithelium [GO:0042248]; morphogenesis of follicular epithelium [GO:0016333]	beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity [GO:0046981]; UDP-glycosyltransferase activity [GO:0008194]	Golgi membrane [GO:0000139]	GO:0000139; GO:0001744; GO:0006688; GO:0007293; GO:0007298; GO:0007299; GO:0008194; GO:0009101; GO:0016333; GO:0030707; GO:0042248; GO:0046981; GO:0140269
GN009038	GN009038.1	Q8N584	47.1	456	462	583	6.73e-137	409	TT39C_HUMAN	Tetratricopeptide repeat protein 39C (TPR repeat protein 39C)	Homo sapiens (Human)	cilium assembly [GO:0060271]; otolith morphogenesis [GO:0032474]			GO:0032474; GO:0060271
GN009041	GN009041.1	Q25074	60.4	53	113	251	1.10e-15	73.2	AQP_HAEIX	Aquaporin (BfWC1) (Water channel 1)	Haematobia irritans exigua (Buffalo fly)	chemical homeostasis [GO:0048878]	water channel activity [GO:0015250]	plasma membrane [GO:0005886]	GO:0005886; GO:0015250; GO:0048878
GN009045	GN009045.1	Q14008	46.2	2063	2020	2032	0.0	1623	CKAP5_HUMAN	Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG)	Homo sapiens (Human)	centrosome cycle [GO:0007098]; centrosome duplication [GO:0051298]; chromosome segregation [GO:0007059]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; microtubule depolymerization [GO:0007019]; microtubule polymerization [GO:0046785]; mitotic cell cycle [GO:0000278]; mitotic spindle organization [GO:0007052]; positive regulation of microtubule nucleation [GO:0090063]; RNA transport [GO:0050658]; spindle organization [GO:0007051]	cadherin binding [GO:0045296]; microtubule binding [GO:0008017]; microtubule plus end polymerase activity [GO:0061863]; microtubule plus-end binding [GO:0051010]; ribonucleoprotein complex binding [GO:0043021]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; mitotic spindle microtubule [GO:1990498]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]	GO:0000278; GO:0000776; GO:0000922; GO:0005737; GO:0005813; GO:0005828; GO:0005829; GO:0007019; GO:0007051; GO:0007052; GO:0007059; GO:0007098; GO:0008017; GO:0016020; GO:0030951; GO:0032991; GO:0043021; GO:0045296; GO:0046785; GO:0050658; GO:0051010; GO:0051298; GO:0061863; GO:0090063; GO:1990498
GN009046	GN009046.1	Q62318	26.9	212	702	834	4.96e-12	73.2	TIF1B_MOUSE	Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-A-interacting protein) (KRIP-1) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; chromatin organization [GO:0006325]; convergent extension involved in axis elongation [GO:0060028]; DNA damage response [GO:0006974]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epigenetic programming of gene expression [GO:0043045]; epithelial to mesenchymal transition [GO:0001837]; genomic imprinting [GO:0071514]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of type I interferon production [GO:0032481]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; promoter-specific chromatin binding [GO:1990841]; protein kinase activity [GO:0004672]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0001701; GO:0001837; GO:0003677; GO:0003682; GO:0003713; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0006281; GO:0006325; GO:0006346; GO:0006468; GO:0006974; GO:0007566; GO:0008270; GO:0016567; GO:0016925; GO:0019789; GO:0031625; GO:0032481; GO:0032991; GO:0035851; GO:0042307; GO:0043045; GO:0043124; GO:0043161; GO:0044790; GO:0045087; GO:0045739; GO:0045869; GO:0045892; GO:0045893; GO:0046777; GO:0060028; GO:0060669; GO:0061630; GO:0061665; GO:0070087; GO:0071514; GO:0090575; GO:0140374; GO:0140463; GO:1990841
GN009057	GN009057.1	Q5UPX0	27.6	243	322	548	2.66e-17	85.9	YR290_MIMIV	Putative ATP-dependent RNA helicase R290 (EC 3.6.4.13)	Acanthamoeba polyphaga mimivirus (APMV)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]		GO:0003676; GO:0003724; GO:0005524; GO:0006260; GO:0006281; GO:0006310; GO:0016887; GO:0043138
GN009066	GN009066.1	O73853	36.0	317	352	514	9.97e-44	160	CP17A_ICTPU	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)	Ictalurus punctatus (Channel catfish) (Silurus punctatus)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid biosynthetic process [GO:0006694]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	membrane [GO:0016020]	GO:0004508; GO:0005506; GO:0006694; GO:0016020; GO:0020037; GO:0042446; GO:0042448
GN009067	GN009067.1	Q8TC57	31.3	144	149	530	3.38e-15	74.7	M1AP_HUMAN	Meiosis 1 arrest protein (Meiosis 1-arresting protein) (Meiosis 1-associated protein) (Spermatogenesis-associated protein 37)	Homo sapiens (Human)	chromatin organization [GO:0006325]; female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; male meiosis chromosome separation [GO:0051308]; meiotic DNA double-strand break formation [GO:0042138]; resolution of meiotic recombination intermediates [GO:0000712]; RNA processing [GO:0006396]; spermatogenesis [GO:0007283]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; membrane [GO:0016020]; recombination nodule [GO:0005713]	GO:0000712; GO:0005713; GO:0005737; GO:0006325; GO:0006396; GO:0007129; GO:0007283; GO:0007292; GO:0016020; GO:0042138; GO:0042802; GO:0051308
GN009069	GN009069.1	Q8TC57	30.8	130	181	530	7.12e-10	60.5	M1AP_HUMAN	Meiosis 1 arrest protein (Meiosis 1-arresting protein) (Meiosis 1-associated protein) (Spermatogenesis-associated protein 37)	Homo sapiens (Human)	chromatin organization [GO:0006325]; female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; male meiosis chromosome separation [GO:0051308]; meiotic DNA double-strand break formation [GO:0042138]; resolution of meiotic recombination intermediates [GO:0000712]; RNA processing [GO:0006396]; spermatogenesis [GO:0007283]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; membrane [GO:0016020]; recombination nodule [GO:0005713]	GO:0000712; GO:0005713; GO:0005737; GO:0006325; GO:0006396; GO:0007129; GO:0007283; GO:0007292; GO:0016020; GO:0042138; GO:0042802; GO:0051308
GN009074	GN009074.1	Q8IZU3	56.8	190	234	236	1.38e-60	193	SYCP3_HUMAN	Synaptonemal complex protein 3 (SCP-3)	Homo sapiens (Human)	homologous chromosome pairing at meiosis [GO:0007129]; homologous recombination [GO:0035825]; male meiosis I [GO:0007141]; meiotic cell cycle [GO:0051321]; reciprocal meiotic recombination [GO:0007131]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]		chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; condensed nuclear chromosome [GO:0000794]; lateral element [GO:0000800]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]	GO:0000775; GO:0000794; GO:0000795; GO:0000800; GO:0005634; GO:0005694; GO:0007129; GO:0007131; GO:0007141; GO:0007286; GO:0035092; GO:0035825; GO:0051321
GN009075	GN009075.1	O14756	40.5	291	394	317	4.21e-61	202	H17B6_HUMAN	17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.239) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 6)	Homo sapiens (Human)	androgen biosynthetic process [GO:0006702]; androgen catabolic process [GO:0006710]; brexanolone catabolic process [GO:0062175]; estrogen biosynthetic process [GO:0006703]; retinol metabolic process [GO:0042572]	5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity [GO:0047024]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity [GO:0047044]; androsterone dehydrogenase [NAD(P)+] activity [GO:0047023]; catalytic activity [GO:0003824]; electron transfer activity [GO:0009055]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; oxidoreductase activity [GO:0016491]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; testosterone dehydrogenase (NADP+) activity [GO:0047045]	early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]	GO:0003824; GO:0004303; GO:0004745; GO:0005783; GO:0006702; GO:0006703; GO:0006710; GO:0009055; GO:0016491; GO:0031901; GO:0042572; GO:0047023; GO:0047024; GO:0047035; GO:0047044; GO:0047045; GO:0062175
GN009077	GN009077.1	Q96BK5	46.6	178	730	328	3.77e-36	142	PINX1_HUMAN	PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1)	Homo sapiens (Human)	mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of protein localization to nucleolus [GO:1904751]; protein localization to chromosome, telomeric region [GO:0070198]; protein localization to nucleolus [GO:1902570]; regulation of protein stability [GO:0031647]; telomere maintenance via telomerase [GO:0007004]	protein-containing complex binding [GO:0044877]; telomerase inhibitor activity [GO:0010521]; telomerase RNA binding [GO:0070034]	chromosome, telomeric region [GO:0000781]; kinetochore [GO:0000776]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0000228; GO:0000776; GO:0000781; GO:0005634; GO:0005654; GO:0005730; GO:0005819; GO:0007004; GO:0007080; GO:0008285; GO:0010521; GO:0010972; GO:0031397; GO:0031647; GO:0032211; GO:0044877; GO:0070034; GO:0070198; GO:1902570; GO:1904357; GO:1904751
GN009078	GN009078.1	P62205	66.1	495	514	598	6.70e-239	671	PLK1_XENTR	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Plx1) (Polo-like kinase 1) (PLK-1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mitotic cell cycle [GO:0000278]; mitotic cleavage furrow formation [GO:1903673]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic spindle organization [GO:0007052]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein localization to chromatin [GO:0071168]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle pole [GO:0000922]	GO:0000278; GO:0000776; GO:0000922; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0007052; GO:0007095; GO:0030496; GO:0071168; GO:0106310; GO:1903673; GO:2000042
GN009080	GN009080.1	Q2KIM0	68.3	161	162	468	1.36e-83	256	FUCO_BOVIN	Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1)	Bos taurus (Bovine)	fucose metabolic process [GO:0006004]; glycolipid catabolic process [GO:0019377]; glycoside catabolic process [GO:0016139]	alpha-L-fucosidase activity [GO:0004560]	lysosome [GO:0005764]	GO:0004560; GO:0005764; GO:0006004; GO:0016139; GO:0019377
GN009082	GN009082.1	O05527	34.8	296	383	494	4.10e-48	173	PHB_DELAC	Poly(3-hydroxybutyrate) depolymerase (P(3HB) depolymerase) (EC 3.1.1.75) (Polyhydroxybutyrate depolymerase) (PHB depolymerase)	Delftia acidovorans (Pseudomonas acidovorans) (Comamonas acidovorans)		poly(3-hydroxybutyrate) depolymerase activity [GO:0050526]	extracellular region [GO:0005576]	GO:0005576; GO:0050526
GN009083	GN009083.1	Q3UUJ4	41.0	410	406	431	2.49e-97	300	STRAA_MOUSE	STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein)	Mus musculus (Mouse)	activation of protein kinase activity [GO:0032147]; G1 to G0 transition [GO:0070314]; protein export from nucleus [GO:0006611]	ATP binding [GO:0005524]; kinase binding [GO:0019900]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activator activity [GO:0043539]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular protein-containing complex [GO:0140535]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; serine/threonine protein kinase complex [GO:1902554]	GO:0004672; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006611; GO:0019900; GO:0030295; GO:0032147; GO:0032991; GO:0043539; GO:0044877; GO:0070314; GO:0140535; GO:1902554
GN009084	GN009084.1	Q7ZYA2	50.6	269	278	293	1.09e-79	245	TAF8_XENLA	Transcription initiation factor TFIID subunit 8 (TBP-associated factor 8)	Xenopus laevis (African clawed frog)	transcription initiation at RNA polymerase II promoter [GO:0006367]	protein heterodimerization activity [GO:0046982]	cytoplasm [GO:0005737]; transcription factor TFIID complex [GO:0005669]	GO:0005669; GO:0005737; GO:0006367; GO:0046982
GN009085	GN009085.1	Q9Y4F9	27.8	986	989	1068	1.54e-90	315	RIPR2_HUMAN	Rho family-interacting cell polarization regulator 2	Homo sapiens (Human)	cellular response to chemokine [GO:1990869]; negative regulation of cell adhesion [GO:0007162]; negative regulation of establishment of T cell polarity [GO:1903904]; negative regulation of protein localization to cell leading edge [GO:1905872]; negative regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001107]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of T cell migration [GO:2000405]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil extravasation [GO:2000391]; regulation of cell cycle [GO:0051726]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitotic spindle assembly [GO:1901673]; sensory perception of sound [GO:0007605]	14-3-3 protein binding [GO:0071889]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; filopodium [GO:0030175]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]	GO:0005737; GO:0005829; GO:0005856; GO:0007162; GO:0007605; GO:0016324; GO:0030175; GO:0032420; GO:0035024; GO:0042130; GO:0045663; GO:0051491; GO:0051726; GO:0060171; GO:0071889; GO:0090023; GO:1901673; GO:1901741; GO:1903904; GO:1905872; GO:1990869; GO:2000114; GO:2000391; GO:2000405; GO:2001107
GN009087	GN009087.1	P54145	47.6	437	486	534	2.99e-118	360	AMT1_CAEEL	Putative ammonium transporter 1	Caenorhabditis elegans	ammonium homeostasis [GO:0097272]	ammonium channel activity [GO:0008519]	membrane [GO:0016020]	GO:0008519; GO:0016020; GO:0097272
GN009088	GN009088.1	Q9WUM7	77.9	263	328	1168	9.61e-118	369	HIPK2_MESAU	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Mx-interacting protein kinase) (PKM)	Mesocricetus auratus (Golden hamster)	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of transcription by RNA polymerase II [GO:0045944]; smoothened signaling pathway [GO:0007224]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nuclear body [GO:0016604]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0003713; GO:0003714; GO:0004674; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0007224; GO:0010494; GO:0016604; GO:0016605; GO:0018105; GO:0042771; GO:0045944; GO:0046332; GO:0106310
GN009090	GN009090.1	Q9H2X6	62.1	58	78	1198	3.77e-21	88.6	HIPK2_HUMAN	Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)	Homo sapiens (Human)	cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; epigenetic regulation of gene expression [GO:0040029]; erythrocyte differentiation [GO:0030218]; eye development [GO:0001654]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; iris morphogenesis [GO:0061072]; lens induction in camera-type eye [GO:0060235]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neuron differentiation [GO:0030182]; peptidyl-serine phosphorylation [GO:0018105]; PML body organization [GO:0030578]; positive regulation of angiogenesis [GO:0045766]; positive regulation of JNK cascade [GO:0046330]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; retina layer formation [GO:0010842]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; virion binding [GO:0046790]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0001654; GO:0003713; GO:0003714; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006468; GO:0007224; GO:0010494; GO:0010842; GO:0016604; GO:0016605; GO:0018105; GO:0030182; GO:0030218; GO:0030330; GO:0030511; GO:0030514; GO:0030578; GO:0040029; GO:0042771; GO:0045766; GO:0045944; GO:0046330; GO:0046332; GO:0046790; GO:0048596; GO:0051726; GO:0060059; GO:0060235; GO:0060395; GO:0061072; GO:0061629; GO:0071456; GO:0090575; GO:0097193; GO:0106310; GO:1901796; GO:2000059
GN009091	GN009091.1	Q9YH37	36.7	98	101	184	1.35e-15	71.2	RAP1B_CYPCA	Ras-related protein Rap-1b (EC 3.6.5.2)	Cyprinus carpio (Common carp)	Rap protein signal transduction [GO:0032486]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	anchoring junction [GO:0070161]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005525; GO:0005829; GO:0005886; GO:0032486; GO:0070161
GN009098	GN009098.1	O73917	55.7	476	478	437	7.15e-150	437	PAX6_ORYLA	Paired box protein Pax-6	Oryzias latipes (Japanese rice fish) (Japanese killifish)	brain development [GO:0007420]; forebrain development [GO:0030900]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; sensory organ development [GO:0007423]; sensory organ morphogenesis [GO:0090596]; type B pancreatic cell differentiation [GO:0003309]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0003309; GO:0005634; GO:0006357; GO:0007420; GO:0007423; GO:0030900; GO:0045944; GO:0060041; GO:0090596
GN009103	GN009103.1	Q9D8N3	48.5	163	180	241	1.44e-46	155	TM86A_MOUSE	Lysoplasmalogenase TMEM86A (EC 3.3.2.2) (Transmembrane protein 86A)	Mus musculus (Mouse)		alkenylglycerophosphocholine hydrolase activity [GO:0047408]; hydrolase activity [GO:0016787]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0005789; GO:0016020; GO:0016787; GO:0047408
GN009105	GN009105.1	Q8BSY0	49.3	436	888	741	9.36e-135	423	ASPH_MOUSE	Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase)	Mus musculus (Mouse)	activation of store-operated calcium channel activity [GO:0032237]; calcium ion homeostasis [GO:0055074]; calcium ion transmembrane transport [GO:0070588]; cellular response to calcium ion [GO:0071277]; face morphogenesis [GO:0060325]; limb morphogenesis [GO:0035108]; negative regulation of cell population proliferation [GO:0008285]; pattern specification process [GO:0007389]; peptidyl-aspartic acid hydroxylation [GO:0042264]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteolysis [GO:0045862]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of protein depolymerization [GO:1901879]; regulation of protein stability [GO:0031647]; response to ATP [GO:0033198]; roof of mouth development [GO:0060021]	calcium ion binding [GO:0005509]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]	cortical endoplasmic reticulum [GO:0032541]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sarcoplasmic reticulum membrane [GO:0033017]	GO:0005509; GO:0005737; GO:0005783; GO:0005789; GO:0005886; GO:0007389; GO:0008285; GO:0010524; GO:0016020; GO:0031647; GO:0032237; GO:0032541; GO:0033017; GO:0033198; GO:0035108; GO:0042264; GO:0045862; GO:0045893; GO:0048015; GO:0051480; GO:0055074; GO:0060021; GO:0060325; GO:0062101; GO:0070588; GO:0071277; GO:0090316; GO:1901879
GN009111	GN009111.1	P29371	24.9	241	340	465	4.00e-10	64.3	NK3R_HUMAN	Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; conditioned place preference [GO:1990708]; drinking behavior [GO:0042756]; phospholipase C-activating tachykinin receptor signaling pathway [GO:0007209]; positive regulation of blood pressure [GO:0045777]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of heart rate [GO:0010460]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of uterine smooth muscle contraction [GO:0070474]; regulation of dopamine metabolic process [GO:0042053]; regulation of feeding behavior [GO:0060259]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; tachykinin receptor signaling pathway [GO:0007217]; vagina development [GO:0060068]	neuromedin K receptor activity [GO:0016498]; tachykinin receptor activity [GO:0004995]	axon terminus [GO:0043679]; dendritic spine head [GO:0044327]; dendritic spine membrane [GO:0032591]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]	GO:0004995; GO:0005886; GO:0007189; GO:0007209; GO:0007217; GO:0010460; GO:0016498; GO:0032355; GO:0032591; GO:0032809; GO:0033686; GO:0042053; GO:0042220; GO:0042756; GO:0043679; GO:0044327; GO:0045777; GO:0060068; GO:0060259; GO:0070474; GO:0097225; GO:1902093; GO:1990708
GN009116	GN009116.1	Q9R1X4	36.6	443	771	1197	1.60e-73	263	TIM_MOUSE	Protein timeless homolog (mTim)	Mus musculus (Mouse)	branching involved in ureteric bud morphogenesis [GO:0001658]; branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle phase transition [GO:0044770]; cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to hydroxyurea [GO:0072711]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; kidney development [GO:0001822]; lung development [GO:0030324]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; morphogenesis of an epithelium [GO:0002009]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of circadian rhythm [GO:0042752]; replication fork arrest [GO:0043111]; replication fork processing [GO:0031297]	DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork protection complex [GO:0031298]; site of double-strand break [GO:0035861]	GO:0000076; GO:0000122; GO:0000785; GO:0001658; GO:0001822; GO:0002009; GO:0003677; GO:0005634; GO:0005654; GO:0005694; GO:0006281; GO:0006974; GO:0007623; GO:0008047; GO:0030324; GO:0031297; GO:0031298; GO:0031573; GO:0035861; GO:0042752; GO:0042753; GO:0042802; GO:0043111; GO:0044770; GO:0045892; GO:0048754; GO:0072711; GO:0072719; GO:1904976; GO:1905168; GO:2000781
GN009118	GN009118.1	Q9UNS1	55.3	653	652	1208	2.46e-229	674	TIM_HUMAN	Protein timeless homolog (hTIM)	Homo sapiens (Human)	cell cycle phase transition [GO:0044770]; cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to hydroxyurea [GO:0072711]; circadian rhythm [GO:0007623]; detection of abiotic stimulus [GO:0009582]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint signaling [GO:0000076]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; morphogenesis of an epithelium [GO:0002009]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of circadian rhythm [GO:0042752]; replication fork arrest [GO:0043111]; replication fork processing [GO:0031297]	DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]	chromatin [GO:0000785]; chromosome [GO:0005694]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork protection complex [GO:0031298]; site of double-strand break [GO:0035861]	GO:0000076; GO:0000785; GO:0002009; GO:0003677; GO:0005634; GO:0005654; GO:0005694; GO:0006281; GO:0006974; GO:0007623; GO:0008047; GO:0009582; GO:0031297; GO:0031298; GO:0031573; GO:0035861; GO:0042752; GO:0042802; GO:0043111; GO:0043596; GO:0044770; GO:0045892; GO:0072711; GO:0072719; GO:1904976; GO:1905168; GO:2000781
GN009119	GN009119.1	Q8IZP0	39.7	524	440	508	1.31e-89	284	ABI1_HUMAN	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)	Homo sapiens (Human)	actin polymerization or depolymerization [GO:0008154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; negative regulation of cell population proliferation [GO:0008285]; neuron migration [GO:0001764]; positive regulation of protein tyrosine kinase activity [GO:0061098]	cadherin binding [GO:0045296]; cytoskeletal protein binding [GO:0008092]; protein tyrosine kinase activator activity [GO:0030296]; SH3 domain binding [GO:0017124]; signaling adaptor activity [GO:0035591]	actin-based cell projection [GO:0098858]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; filopodium tip [GO:0032433]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; SCAR complex [GO:0031209]	GO:0001764; GO:0005634; GO:0005783; GO:0005829; GO:0007169; GO:0008092; GO:0008154; GO:0008285; GO:0014069; GO:0017124; GO:0030027; GO:0030296; GO:0030426; GO:0031209; GO:0032433; GO:0035591; GO:0045296; GO:0061098; GO:0070062; GO:0098858
GN009121	GN009121.1	P20009	60.1	173	318	327	1.23e-41	150	DLL_DROME	Homeotic protein distal-less (Protein brista)	Drosophila melanogaster (Fruit fly)	analia development [GO:0007487]; antennal development [GO:0007469]; cell differentiation [GO:0030154]; determination of ventral identity [GO:0048264]; genital disc development [GO:0035215]; imaginal disc-derived appendage morphogenesis [GO:0035114]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived male genitalia development [GO:0007485]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; leg disc proximal/distal pattern formation [GO:0007479]; mushroom body development [GO:0016319]; negative regulation of gene expression [GO:0010629]; positive regulation of DNA-templated transcription [GO:0045893]; proboscis development [GO:0048728]; proximal/distal pattern formation, imaginal disc [GO:0007449]; regulation of transcription by RNA polymerase II [GO:0006357]; specification of animal organ identity [GO:0010092]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0007449; GO:0007469; GO:0007479; GO:0007480; GO:0007485; GO:0007487; GO:0008587; GO:0010092; GO:0010629; GO:0016319; GO:0030154; GO:0035114; GO:0035215; GO:0045893; GO:0048264; GO:0048728
GN009131	GN009131.1	Q4KLQ5	48.1	349	375	580	9.72e-101	312	WDR76_XENLA	WD repeat-containing protein 76	Xenopus laevis (African clawed frog)	regulation of DNA damage checkpoint [GO:2000001]	DNA binding [GO:0003677]	nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:2000001
GN009132	GN009132.1	P40237	26.3	259	293	266	9.53e-15	75.9	CD82_MOUSE	CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1 homolog) (CD antigen CD82)	Mus musculus (Mouse)			phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	GO:0005886; GO:0045335
GN009133	GN009133.1	A6NJ78	50.7	339	436	407	1.26e-99	306	MET15_HUMAN	12S rRNA N(4)-cytidine methyltransferase METTL15 (12S rRNA m4C methyltransferase) (EC 2.1.1.-) (Methyltransferase 5 domain-containing protein 1) (Methyltransferase-like protein 15)	Homo sapiens (Human)	mitochondrial small ribosomal subunit assembly [GO:0180026]; rRNA base methylation [GO:0070475]	rRNA (cytosine-N4-)-methyltransferase activity [GO:0071424]	methyltransferase complex [GO:0034708]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0034708; GO:0070475; GO:0071424; GO:0180026
GN009140	GN009140.1	Q9UBU6	35.5	197	296	413	6.04e-28	114	FA8A1_HUMAN	Protein FAM8A1 (Autosomal highly conserved protein)	Homo sapiens (Human)	ERAD pathway [GO:0036503]		Hrd1p ubiquitin ligase complex [GO:0000836]	GO:0000836; GO:0036503
GN009145	GN009145.1	Q7ZXH2	33.9	221	231	238	1.34e-29	113	NSE2_XENLA	E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog)	Xenopus laevis (African clawed frog)	cellular senescence [GO:0090398]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein sumoylation [GO:0016925]; telomere maintenance via recombination [GO:0000722]	SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; zinc ion binding [GO:0008270]	chromosome, telomeric region [GO:0000781]; nucleus [GO:0005634]; PML body [GO:0016605]; Smc5-Smc6 complex [GO:0030915]	GO:0000722; GO:0000724; GO:0000781; GO:0005634; GO:0008270; GO:0016605; GO:0016925; GO:0019789; GO:0030915; GO:0034184; GO:0045842; GO:0061665; GO:0090398
GN009150	GN009150.1	A4FUZ5	48.9	438	425	472	7.06e-137	403	SERC3_BOVIN	Serine incorporator 3	Bos taurus (Bovine)	antiviral innate immune response [GO:0140374]; plasma membrane phospholipid scrambling [GO:0017121]	phospholipid scramblase activity [GO:0017128]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0000139; GO:0005886; GO:0016020; GO:0017121; GO:0017128; GO:0140374
GN009153	GN009153.1	Q9UQ80	66.7	75	97	394	4.85e-30	112	PA2G4_HUMAN	Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1)	Homo sapiens (Human)	negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of cell differentiation [GO:0045597]	nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003676; GO:0003714; GO:0003723; GO:0005576; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0016020; GO:0031625; GO:0035578; GO:0043066; GO:0045597; GO:0045892; GO:0070062
GN009157	GN009157.1	Q3SZ45	63.6	184	226	211	4.94e-83	249	SDF2_BOVIN	Stromal cell-derived factor 2 (SDF-2)	Bos taurus (Bovine)			endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; protein-containing complex [GO:0032991]	GO:0005576; GO:0005783; GO:0032991
GN009158	GN009158.1	Q6DEJ5	53.7	374	416	412	4.32e-139	406	AASD1_DANRE	Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of translational fidelity [GO:0006450]; tRNA aminoacylation [GO:0043039]	aminoacyl-tRNA ligase activity [GO:0004812]; ATP binding [GO:0005524]; Ser-tRNA(Ala) deacylase activity [GO:0002196]	cytoplasm [GO:0005737]	GO:0002196; GO:0004812; GO:0005524; GO:0005737; GO:0006450; GO:0043039
GN009163	GN009163.1	P47875	50.3	177	183	193	9.28e-61	190	CSRP1_RAT	Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP) (CRP1)	Rattus norvegicus (Rat)	muscle tissue development [GO:0060537]; nervous system development [GO:0007399]; sarcomere organization [GO:0045214]	actinin binding [GO:0042805]; structural constituent of muscle [GO:0008307]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; Z disc [GO:0030018]	GO:0005634; GO:0005737; GO:0007399; GO:0008307; GO:0030018; GO:0042805; GO:0045214; GO:0060537
GN009165	GN009165.1	Q8N8K9	26.7	202	223	716	1.14e-11	67.0	K1958_HUMAN	Uncharacterized protein KIAA1958	Homo sapiens (Human)				
GN009166	GN009166.1	Q61212	28.6	234	420	371	6.69e-13	73.2	NPY6R_MOUSE	Neuropeptide Y receptor type 6 (NPY6-R) (Pancreatic polypeptide receptor 2) (PP2)	Mus musculus (Mouse)		neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]; peptide YY receptor activity [GO:0001601]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]	GO:0001601; GO:0004983; GO:0005886; GO:0008188; GO:0043005
GN009168	GN009168.1	B4F6I5	59.9	324	349	446	1.62e-139	406	FICD_XENTR	Protein adenylyltransferase FICD (EC 2.7.7.108) (AMPylator FICD) (De-AMPylase FICD) (EC 3.1.4.-) (FIC domain-containing protein)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	protein adenylylation [GO:0018117]; protein deadenylylation [GO:0044602]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; response to endoplasmic reticulum stress [GO:0034976]	AMPylase activity [GO:0070733]; ATP binding [GO:0005524]; Hsp70 protein binding [GO:0030544]; protein adenylylhydrolase activity [GO:0044603]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005524; GO:0005783; GO:0005789; GO:0018117; GO:0030544; GO:0034976; GO:0042803; GO:0044602; GO:0044603; GO:0051087; GO:0070733; GO:1903894
GN009169	GN009169.1	Q6DRI7	47.3	528	591	652	7.48e-147	441	DDX51_DANRE	ATP-dependent RNA helicase DDX51 (EC 3.6.4.13) (DEAD box protein 51)	Danio rerio (Zebrafish) (Brachydanio rerio)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0005524; GO:0005634; GO:0005730; GO:0016887
GN009176	GN009176.1	Q5IS76	29.8	319	409	494	2.15e-44	164	ACHA6_PANTR	Neuronal acetylcholine receptor subunit alpha-6	Pan troglodytes (Chimpanzee)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0014059; GO:0015464; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN009177	GN009177.1	Q5IS76	27.9	319	410	494	2.93e-41	155	ACHA6_PANTR	Neuronal acetylcholine receptor subunit alpha-6	Pan troglodytes (Chimpanzee)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0014059; GO:0015464; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN009178	GN009178.1	Q9R0W9	27.7	311	396	494	1.54e-41	155	ACHA6_MOUSE	Neuronal acetylcholine receptor subunit alpha-6	Mus musculus (Mouse)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; cation channel complex [GO:0034703]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; neurotransmitter receptor complex [GO:0098878]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0014059; GO:0022848; GO:0030594; GO:0032991; GO:0034220; GO:0034703; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0098878; GO:0099171
GN009179	GN009179.1	Q9XYM0	50.8	258	252	271	5.28e-81	247	CRK_DROME	Adapter molecule Crk	Drosophila melanogaster (Fruit fly)	border follicle cell migration [GO:0007298]; cell migration [GO:0016477]; enzyme-linked receptor protein signaling pathway [GO:0007167]; ephrin receptor signaling pathway [GO:0048013]; imaginal disc fusion, thorax closure [GO:0046529]; myoblast fusion [GO:0007520]; phagocytosis, engulfment [GO:0006911]; positive regulation of JNK cascade [GO:0046330]; regulation of actin cytoskeleton organization [GO:0032956]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	receptor tyrosine kinase binding [GO:0030971]; signaling adaptor activity [GO:0035591]	cytoplasm [GO:0005737]	GO:0005737; GO:0006911; GO:0007167; GO:0007298; GO:0007520; GO:0016477; GO:0030971; GO:0032956; GO:0035591; GO:0046330; GO:0046529; GO:0048010; GO:0048013
GN009180	GN009180.1	O42412	43.1	116	120	258	4.75e-29	108	IOD3_CHICK	Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase)	Gallus gallus (Chicken)	thyroid hormone catabolic process [GO:0042404]; thyroid hormone metabolic process [GO:0042403]	thyroxine 5'-deiodinase activity [GO:0004800]; thyroxine 5-deiodinase activity [GO:0033798]	endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	GO:0004800; GO:0005886; GO:0010008; GO:0033798; GO:0042403; GO:0042404
GN009181	GN009181.1	Q6U6H1	55.8	43	134	259	1.11e-09	57.8	IOD_HALRO	Thyroxine 5'-deiodinase (EC 1.21.99.4) (Iodothyronine deiodinase)	Halocynthia roretzi (Sea squirt) (Cynthia roretzi)	thyroid hormone metabolic process [GO:0042403]	thyroxine 5'-deiodinase activity [GO:0004800]	membrane [GO:0016020]; nucleus [GO:0005634]	GO:0004800; GO:0005634; GO:0016020; GO:0042403
GN009182	GN009182.1	O42412	44.2	120	124	258	1.97e-29	109	IOD3_CHICK	Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase)	Gallus gallus (Chicken)	thyroid hormone catabolic process [GO:0042404]; thyroid hormone metabolic process [GO:0042403]	thyroxine 5'-deiodinase activity [GO:0004800]; thyroxine 5-deiodinase activity [GO:0033798]	endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	GO:0004800; GO:0005886; GO:0010008; GO:0033798; GO:0042403; GO:0042404
GN009188	GN009188.1	Q52V16	30.8	195	1318	801	6.33e-18	93.6	ZFY_GORGO	Zinc finger Y-chromosomal protein	Gorilla gorilla gorilla (Western lowland gorilla)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0046872
GN009189	GN009189.1	Q6P3R8	43.8	272	570	708	5.86e-74	252	NEK5_HUMAN	Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5)	Homo sapiens (Human)		ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cilium [GO:0005929]; sperm flagellum [GO:0036126]	GO:0004672; GO:0004674; GO:0005524; GO:0005929; GO:0036126; GO:0106310
GN009190	GN009190.1	P20807	52.2	136	186	821	5.44e-44	158	CAN3_HUMAN	Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1)	Homo sapiens (Human)	apoptotic process [GO:0006915]; calcium-dependent self proteolysis [GO:1990092]; cellular response to calcium ion [GO:0071277]; cellular response to salt stress [GO:0071472]; G1 to G0 transition involved in cell differentiation [GO:0070315]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein sumoylation [GO:0033234]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of satellite cell activation involved in skeletal muscle regeneration [GO:0014718]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to membrane [GO:0072657]; protein-containing complex assembly [GO:0065003]; proteolysis [GO:0006508]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of myoblast differentiation [GO:0045661]; response to calcium ion [GO:0051592]; response to muscle activity [GO:0014850]; sarcomere organization [GO:0045214]; self proteolysis [GO:0097264]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; catalytic activity [GO:0003824]; cysteine-type peptidase activity [GO:0008234]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; peptidase activity [GO:0008233]; sodium ion binding [GO:0031402]; structural constituent of muscle [GO:0008307]; titin binding [GO:0031432]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; myofibril [GO:0030016]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; T-tubule [GO:0030315]; Z disc [GO:0030018]	GO:0003824; GO:0004198; GO:0005509; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0006508; GO:0006915; GO:0007517; GO:0008233; GO:0008234; GO:0008307; GO:0014718; GO:0014850; GO:0030016; GO:0030018; GO:0030163; GO:0030239; GO:0030315; GO:0031402; GO:0031432; GO:0031648; GO:0032991; GO:0033234; GO:0042802; GO:0043066; GO:0043122; GO:0045214; GO:0045661; GO:0045862; GO:0045892; GO:0045893; GO:0046716; GO:0051281; GO:0051592; GO:0060090; GO:0061061; GO:0065003; GO:0070315; GO:0071277; GO:0071472; GO:0072657; GO:0097264; GO:1990092
GN009192	GN009192.1	Q8C761	39.1	575	988	999	1.44e-107	360	DC2I1_MOUSE	Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60)	Mus musculus (Mouse)	cilium assembly [GO:0060271]; embryonic skeletal system morphogenesis [GO:0048704]; intraciliary retrograde transport [GO:0035721]	dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; interphase microtubule organizing center [GO:0031021]; pericentriolar material [GO:0000242]; spindle pole [GO:0000922]	GO:0000242; GO:0000922; GO:0005813; GO:0005829; GO:0005868; GO:0005929; GO:0031021; GO:0035721; GO:0036064; GO:0045503; GO:0045504; GO:0048704; GO:0060271; GO:0097546
GN009193	GN009193.1	Q7XR46	29.6	469	554	487	2.54e-36	144	PAO4_ORYSJ	Polyamine oxidase 4 (OsPAO4) (EC 1.5.3.-)	Oryza sativa subsp. japonica (Rice)	spermine catabolic process [GO:0046208]; thermospermine catabolic process [GO:1903602]	flavin adenine dinucleotide binding [GO:0050660]; spermine oxidase activity [GO:0052901]; thermospermine oxidase activity [GO:1990534]	peroxisome [GO:0005777]	GO:0005777; GO:0046208; GO:0050660; GO:0052901; GO:1903602; GO:1990534
GN009196	GN009196.1	Q8N0X2	34.8	368	615	631	2.40e-51	190	SPG16_HUMAN	Sperm-associated antigen 16 protein (Pf20 protein homolog)	Homo sapiens (Human)	axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]		axonemal central apparatus [GO:1990716]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]	GO:0005737; GO:0005930; GO:0035082; GO:0036126; GO:0060271; GO:1990716
GN009197	GN009197.1	Q961D9	28.5	235	1281	1469	5.13e-14	81.3	BCL9_DROME	Protein BCL9 homolog (Protein legless)	Drosophila melanogaster (Fruit fly)	canonical Wnt signaling pathway [GO:0060070]; chitin-based larval cuticle pattern formation [GO:0035293]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; leg disc pattern formation [GO:0035223]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; segment polarity determination [GO:0007367]; sternite morphogenesis [GO:0007491]	transcription coactivator activity [GO:0003713]	beta-catenin-TCF complex [GO:1990907]; cytosol [GO:0005829]; enhanceosome [GO:0034206]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005654; GO:0005829; GO:0006357; GO:0007367; GO:0007491; GO:0008587; GO:0034206; GO:0035223; GO:0035293; GO:0045944; GO:0060070; GO:1990907
GN009200	GN009200.1	Q7PD79	42.4	413	431	383	1.43e-99	305	GNAS_ANOGA	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Anopheles gambiae (African malaria mosquito)	adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; sensory perception of chemical stimulus [GO:0007606]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]		GO:0001664; GO:0003924; GO:0005525; GO:0007191; GO:0007606; GO:0031683
GN009201	GN009201.1	Q7PD79	42.2	410	819	383	2.17e-97	311	GNAS_ANOGA	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Anopheles gambiae (African malaria mosquito)	adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; sensory perception of chemical stimulus [GO:0007606]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]		GO:0001664; GO:0003924; GO:0005525; GO:0007191; GO:0007606; GO:0031683
GN009204	GN009204.1	O16118	39.8	261	265	379	3.84e-56	187	GNAS_HOMAM	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Homarus americanus (American lobster)	adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; sensory perception of chemical stimulus [GO:0007606]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; heterotrimeric G-protein complex [GO:0005834]	GO:0001664; GO:0003924; GO:0005525; GO:0005737; GO:0005834; GO:0007191; GO:0007606; GO:0031683
GN009206	GN009206.1	Q67ER4	61.5	278	329	343	1.01e-120	353	R113A_BOVIN	E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (RING finger protein 113A) (Zinc finger protein 183)	Bos taurus (Bovine)	mRNA splicing, via spliceosome [GO:0000398]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; protein ubiquitination [GO:0016567]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	GO:0000398; GO:0004842; GO:0005634; GO:0005684; GO:0016567; GO:0016607; GO:0046872; GO:0061630; GO:0070100; GO:0071005
GN009207	GN009207.1	Q1LUQ4	38.8	554	572	793	7.18e-80	270	MFD6A_DANRE	Major facilitator superfamily domain-containing protein 6-A (Macrophage MHC class I receptor 2 homolog A)	Danio rerio (Zebrafish) (Brachydanio rerio)	antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]		plasma membrane [GO:0005886]	GO:0005886; GO:0042590
GN009208	GN009208.1	Q8CBH5	56.5	115	232	775	2.24e-37	141	MFSD6_MOUSE	Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2)	Mus musculus (Mouse)	antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]	MHC class I protein binding [GO:0042288]; MHC class I receptor activity [GO:0032393]	plasma membrane [GO:0005886]	GO:0005886; GO:0032393; GO:0042288; GO:0042590
GN009209	GN009209.1	Q20655	70.5	241	251	248	2.16e-106	310	14332_CAEEL	14-3-3-like protein 2	Caenorhabditis elegans	dauer larval development [GO:0040024]; intracellular protein localization [GO:0008104]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of gene expression [GO:0010629]; negative regulation of protein import into nucleus [GO:0042308]; regulation of gene expression [GO:0010468]	DNA-binding transcription factor binding [GO:0140297]; protein sequestering activity [GO:0140311]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0008104; GO:0010468; GO:0010629; GO:0040024; GO:0042308; GO:0051457; GO:0140297; GO:0140311
GN009211	GN009211.1	Q3L1C9	56.9	612	677	950	1.09e-191	570	STAUH_APLCA	Double-stranded RNA-binding protein Staufen homolog	Aplysia californica (California sea hare)	anterograde dendritic transport of messenger ribonucleoprotein complex [GO:0098964]; germ cell development [GO:0007281]; intracellular mRNA localization [GO:0008298]; protein localization to synapse [GO:0035418]; regulation of protein localization [GO:0032880]	double-stranded RNA binding [GO:0003725]; mRNA binding [GO:0003729]	cytoplasmic stress granule [GO:0010494]; dendrite cytoplasm [GO:0032839]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]	GO:0003725; GO:0003729; GO:0005886; GO:0007281; GO:0008298; GO:0010494; GO:0032839; GO:0032880; GO:0035418; GO:0043005; GO:0043025; GO:0043204; GO:0098964
GN009212	GN009212.1	Q8IX29	44.2	231	351	292	5.10e-60	197	FBX16_HUMAN	F-box only protein 16	Homo sapiens (Human)	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]		SCF ubiquitin ligase complex [GO:0019005]	GO:0019005; GO:0031146
GN009213	GN009213.1	P02597	27.3	132	190	149	5.51e-10	58.5	CALMS_CHICK	Calmodulin, striated muscle	Gallus gallus (Chicken)	calcineurin-mediated signaling [GO:0097720]; detection of calcium ion [GO:0005513]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	calcium ion binding [GO:0005509]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; myelin sheath [GO:0043209]; nucleus [GO:0005634]	GO:0005509; GO:0005513; GO:0005634; GO:0005737; GO:0005813; GO:0010880; GO:0043209; GO:0097720
GN009214	GN009214.1	Q61212	27.9	140	413	371	9.01e-09	60.5	NPY6R_MOUSE	Neuropeptide Y receptor type 6 (NPY6-R) (Pancreatic polypeptide receptor 2) (PP2)	Mus musculus (Mouse)		neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]; peptide YY receptor activity [GO:0001601]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]	GO:0001601; GO:0004983; GO:0005886; GO:0008188; GO:0043005
GN009215	GN009215.1	Q53T59	29.7	317	366	392	3.47e-26	111	H1BP3_HUMAN	HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3)	Homo sapiens (Human)	regulation of apoptotic process [GO:0042981]	phosphatidylinositol binding [GO:0035091]	endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]	GO:0005739; GO:0005783; GO:0035091; GO:0042981
GN009238	GN009238.1	B3EWY9	28.1	861	6164	1594	4.19e-70	268	MLP_ACRMI	Mucin-like protein	Acropora millepora (Staghorn coral) (Heteropora millepora)	cell-matrix adhesion [GO:0007160]	calcium ion binding [GO:0005509]	membrane [GO:0016020]	GO:0005509; GO:0007160; GO:0016020
GN009248	GN009248.1	Q09621	33.3	381	436	473	2.06e-57	199	LACT2_CAEEL	Beta-lactamase domain-containing protein 2	Caenorhabditis elegans			membrane [GO:0016020]	GO:0016020
GN009250	GN009250.1	Q9ZQ47	40.4	282	873	819	1.04e-57	216	GRDP1_ARATH	Glycine-rich domain-containing protein 1 (AtGRDP1)	Arabidopsis thaliana (Mouse-ear cress)	cellular response to osmotic stress [GO:0071470]; regulation of abscisic acid-activated signaling pathway [GO:0009787]; response to osmotic stress [GO:0006970]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005737; GO:0005886; GO:0006970; GO:0009787; GO:0071470
GN009251	GN009251.1	Q7Z7K0	41.6	89	183	106	3.00e-21	86.7	COXM1_HUMAN	COX assembly mitochondrial protein homolog (Cmc1p)	Homo sapiens (Human)	mitochondrial respiratory chain complex IV assembly [GO:0033617]	protein folding chaperone [GO:0044183]	mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005758; GO:0005759; GO:0033617; GO:0044183
GN009252	GN009252.1	Q17QJ7	53.7	270	308	320	8.99e-88	268	P5CR2_BOVIN	Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2)	Bos taurus (Bovine)	cellular response to oxidative stress [GO:0034599]; L-proline biosynthetic process [GO:0055129]	pyrroline-5-carboxylate reductase activity [GO:0004735]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0004735; GO:0005737; GO:0005739; GO:0034599; GO:0055129
GN009253	GN009253.1	Q58DT4	49.4	233	263	320	5.40e-66	211	P5CR1_BOVIN	Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)	Bos taurus (Bovine)	cellular response to oxidative stress [GO:0034599]; L-glutamate catabolic process [GO:0006538]; L-glutamine catabolic process [GO:0006543]; L-proline biosynthetic process [GO:0055129]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; regulation of mitochondrial membrane potential [GO:0051881]	identical protein binding [GO:0042802]; pyrroline-5-carboxylate reductase activity [GO:0004735]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyrroline-5-carboxylate reductase complex [GO:1902792]	GO:0004735; GO:0005739; GO:0005759; GO:0006538; GO:0006543; GO:0034599; GO:0042802; GO:0051881; GO:0055129; GO:1902792; GO:1903377
GN009262	GN009262.1	Q4KMD7	28.9	543	931	797	3.18e-60	223	STPAP_DANRE	Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52)	Danio rerio (Zebrafish) (Brachydanio rerio)	co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; snRNA processing [GO:0016180]	enzyme-substrate adaptor activity [GO:0140767]; mRNA 3'-UTR binding [GO:0003730]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; zinc ion binding [GO:0008270]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]	GO:0003723; GO:0003730; GO:0005730; GO:0005847; GO:0008270; GO:0016180; GO:0016607; GO:0050265; GO:0140767; GO:0180010; GO:1990074; GO:1990817
GN009263	GN009263.1	Q86YT5	41.5	523	551	568	4.95e-126	384	S13A5_HUMAN	Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5)	Homo sapiens (Human)	alpha-ketoglutarate transport [GO:0015742]; cellular response to lithium ion [GO:0071285]; citrate transport [GO:0015746]; fumarate transport [GO:0015741]; oxaloacetate transport [GO:0015729]; succinate transport [GO:0015744]; transmembrane transport [GO:0055085]	citrate transmembrane transporter activity [GO:0015137]; identical protein binding [GO:0042802]; organic acid:sodium symporter activity [GO:0005343]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]	plasma membrane [GO:0005886]	GO:0005343; GO:0005886; GO:0015137; GO:0015141; GO:0015729; GO:0015741; GO:0015742; GO:0015744; GO:0015746; GO:0017153; GO:0042802; GO:0055085; GO:0071285
GN009264	GN009264.1	Q91Y63	49.5	97	121	600	2.55e-25	102	S13A3_MOUSE	Na(+)/dicarboxylate cotransporter 3 (NaDC-3) (mNaDC3) (Na(+)-coupled carboxylate transporter 3) (NaC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) (Solute carrier family 13 member 3)	Mus musculus (Mouse)	aspartate transmembrane transport [GO:0015810]; carboxylic acid transport [GO:0046942]; citrate transport [GO:0015746]; dicarboxylic acid transport [GO:0006835]; glutathione transmembrane transport [GO:0034775]; succinate transmembrane transport [GO:0071422]; succinate transport [GO:0015744]	alpha-ketoglutarate transmembrane transporter activity [GO:0015139]; citrate transmembrane transporter activity [GO:0015137]; dicarboxylic acid transmembrane transporter activity [GO:0005310]; glutathione transmembrane transporter activity [GO:0034634]; high-affinity sodium:dicarboxylate symporter activity [GO:0015362]; L-aspartate transmembrane transporter activity [GO:0015183]; organic acid:sodium symporter activity [GO:0005343]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005310; GO:0005343; GO:0005886; GO:0006835; GO:0015137; GO:0015139; GO:0015141; GO:0015183; GO:0015362; GO:0015744; GO:0015746; GO:0015810; GO:0016020; GO:0016323; GO:0017153; GO:0034634; GO:0034775; GO:0046942; GO:0071422
GN009266	GN009266.1	O95429	37.8	98	464	457	8.56e-10	64.3	BAG4_HUMAN	BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains)	Homo sapiens (Human)	cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein localization to mitochondrion [GO:1903748]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell adhesion [GO:0045785]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of stress fiber assembly [GO:0051496]; protein folding [GO:0006457]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; ruffle assembly [GO:0097178]	adenyl-nucleotide exchange factor activity [GO:0000774]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000774; GO:0003723; GO:0005634; GO:0005829; GO:0005886; GO:0006457; GO:0010763; GO:0016020; GO:0030838; GO:0031625; GO:0043066; GO:0045785; GO:0050821; GO:0051087; GO:0051496; GO:0051897; GO:0071356; GO:0071364; GO:0072659; GO:0097178; GO:1903748
GN009267	GN009267.1	P52034	63.1	757	757	788	0.0	954	PFKA_DROME	ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)	Drosophila melanogaster (Fruit fly)	canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glucose homeostasis [GO:0042593]; glycolytic process [GO:0006096]; response to sucrose [GO:0009744]	6-phosphofructokinase activity [GO:0003872]; ATP binding [GO:0005524]; fructose-6-phosphate binding [GO:0070095]	6-phosphofructokinase complex [GO:0005945]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0003872; GO:0005524; GO:0005739; GO:0005829; GO:0005945; GO:0006002; GO:0006096; GO:0009744; GO:0030388; GO:0042593; GO:0061621; GO:0070095
GN009269	GN009269.1	Q3T0W9	74.5	192	198	196	9.85e-89	261	RL19_BOVIN	Large ribosomal subunit protein eL19 (60S ribosomal protein L19)	Bos taurus (Bovine)	cytoplasmic translation [GO:0002181]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]; nucleolus [GO:0005730]; synapse [GO:0045202]	GO:0002181; GO:0003723; GO:0003735; GO:0005730; GO:0005737; GO:0022625; GO:0045202
GN009270	GN009270.1	Q96D46	58.4	502	501	503	1.96e-216	610	NMD3_HUMAN	60S ribosomal export protein NMD3 (hNMD3)	Homo sapiens (Human)	positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of RNA biosynthetic process [GO:1902680]; ribosomal large subunit export from nucleus [GO:0000055]	protein-macromolecule adaptor activity [GO:0030674]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000055; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0016020; GO:0030674; GO:0043023; GO:1902680; GO:1904751
GN009271	GN009271.1	P17012	29.8	161	1018	799	1.18e-09	66.2	ZFX_MOUSE	Zinc finger X-chromosomal protein	Mus musculus (Mouse)	fertilization [GO:0009566]; germ cell development [GO:0007281]; homeostasis of number of cells [GO:0048872]; multicellular organism growth [GO:0035264]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; parental behavior [GO:0060746]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0001228; GO:0001541; GO:0005634; GO:0005654; GO:0005730; GO:0006357; GO:0007281; GO:0007283; GO:0009566; GO:0009791; GO:0035264; GO:0045944; GO:0046872; GO:0048599; GO:0048872; GO:0060746
GN009272	GN009272.1	E7E2N8	46.9	160	165	251	7.18e-39	135	GILT_CARAU	Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.4.-)	Carassius auratus (Goldfish)	antigen processing and presentation [GO:0019882]	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein-disulfide reductase activity [GO:0015035]	extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0005576; GO:0005764; GO:0015035; GO:0016671; GO:0019882
GN009274	GN009274.1	Q5NUA6	54.8	146	696	607	2.00e-39	157	NF2L2_BOVIN	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2)	Bos taurus (Bovine)	cell redox homeostasis [GO:0045454]; cellular response to fluid shear stress [GO:0071498]; cellular response to oxidative stress [GO:0034599]; negative regulation of ferroptosis [GO:0110076]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of innate immune response [GO:0045088]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000976; GO:0000978; GO:0000981; GO:0003700; GO:0005634; GO:0005737; GO:0005829; GO:0006357; GO:0010499; GO:0016567; GO:0034599; GO:0043161; GO:0043565; GO:0045088; GO:0045454; GO:0045944; GO:0071498; GO:0110076
GN009275	GN009275.1	Q9FFU6	39.2	130	568	907	6.10e-20	97.8	B561A_ARATH	Cytochrome b561, DM13 and DOMON domain-containing protein At5g54830 (Protein b561A.tha1)	Arabidopsis thaliana (Mouse-ear cress)			endosome [GO:0005768]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	GO:0005768; GO:0005794; GO:0005802; GO:0016020
GN009276	GN009276.1	Q0P5X1	32.1	963	1504	1673	3.06e-40	167	LRIQ1_MOUSE	Leucine-rich repeat- and IQ domain-containing protein 1	Mus musculus (Mouse)	apoptotic process [GO:0006915]; gene expression [GO:0010467]; single fertilization [GO:0007338]		microtubule cytoskeleton [GO:0015630]	GO:0006915; GO:0007338; GO:0010467; GO:0015630
GN009279	GN009279.1	P78545	42.6	108	272	371	2.41e-19	89.7	ELF3_HUMAN	ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1)	Homo sapiens (Human)	cell differentiation [GO:0030154]; inflammatory response [GO:0006954]; mammary gland involution [GO:0060056]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0006954; GO:0030154; GO:0045892; GO:0045944; GO:0060056; GO:1990837
GN009281	GN009281.1	Q9ES30	30.7	140	167	246	7.40e-13	67.4	C1QT3_MOUSE	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	Mus musculus (Mouse)	fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; intracellular triglyceride homeostasis [GO:0035356]; maintenance of synapse structure [GO:0099558]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular region [GO:0005576]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001819; GO:0005576; GO:0010629; GO:0032715; GO:0032991; GO:0035356; GO:0042593; GO:0042802; GO:0043083; GO:0045202; GO:0045444; GO:0045721; GO:0050728; GO:0051897; GO:0070165; GO:0070374; GO:0071638; GO:0099550; GO:0099558; GO:1901223
GN009282	GN009282.1	Q5XGP7	36.4	118	850	330	6.13e-15	80.5	SKA2A_XENLA	Src kinase-associated phosphoprotein 2-A	Xenopus laevis (African clawed frog)			cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886
GN009283	GN009283.1	Q9I8C7	43.8	347	557	452	1.68e-92	293	ACH10_CHICK	Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0050910; GO:0097060; GO:1902495
GN009284	GN009284.1	Q6EV56	32.3	325	380	429	2.49e-41	153	OFUT2_PANTR	GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2)	Pan troglodytes (Chimpanzee)	protein O-linked glycosylation via fucose [GO:0036066]	peptide-O-fucosyltransferase activity [GO:0046922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	GO:0005783; GO:0005789; GO:0005794; GO:0036066; GO:0046922
GN009285	GN009285.1	Q9Y2G5	55.3	394	434	429	1.71e-157	454	OFUT2_HUMAN	GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2)	Homo sapiens (Human)	positive regulation of protein folding [GO:1903334]; protein O-linked glycosylation via fucose [GO:0036066]; regulation of secretion [GO:0051046]	peptide-O-fucosyltransferase activity [GO:0046922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	GO:0005783; GO:0005789; GO:0005794; GO:0036066; GO:0046922; GO:0051046; GO:1903334
GN009286	GN009286.1	Q8K0Q5	38.0	639	652	663	7.90e-110	348	RHG18_MOUSE	Rho GTPase-activating protein 18 (Rho-type GTPase-activating protein 18)	Mus musculus (Mouse)	regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GO:0001726; GO:0005096; GO:0005737; GO:0005829; GO:0005881; GO:0005886; GO:0007264; GO:0008360; GO:0016607; GO:0030833; GO:0032956; GO:0051056; GO:2000145
GN009288	GN009288.1	Q6Q4G4	51.5	581	633	616	3.98e-219	626	ACE_THETS	Angiotensin-converting enzyme (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (TtACE)	Theromyzon tessulatum (Duck leech)	proteolysis [GO:0006508]	metallopeptidase activity [GO:0008237]; peptidyl-dipeptidase activity [GO:0008241]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005576; GO:0005886; GO:0006508; GO:0008237; GO:0008241
GN009289	GN009289.1	P59326	43.1	562	527	559	6.72e-117	359	YTHD1_MOUSE	YTH domain-containing family protein 1 (Dermatomyositis associated with cancer putative autoantigen 1 homolog) (DACA-1 homolog)	Mus musculus (Mouse)	learning [GO:0007612]; memory [GO:0007613]; mRNA destabilization [GO:0061157]; organelle assembly [GO:0070925]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; regulation of antigen processing and presentation [GO:0002577]; regulation of axon guidance [GO:1902667]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of mRNA stability [GO:0043488]; stress granule assembly [GO:0034063]	N6-methyladenosine-containing RNA reader activity [GO:1990247]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932]	GO:0000932; GO:0002577; GO:0003723; GO:0005737; GO:0007612; GO:0007613; GO:0010494; GO:0034063; GO:0043022; GO:0043488; GO:0045727; GO:0045948; GO:0061157; GO:0070925; GO:1900271; GO:1902667; GO:1990247
GN009290	GN009290.1	P57071	38.3	167	1452	1141	7.88e-25	116	PRD15_HUMAN	PR domain zinc finger protein 15 (EC 2.1.1.-) (PR domain-containing protein 15) (Zinc finger protein 298)	Homo sapiens (Human)	negative regulation of MAPK cascade [GO:0043409]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stem cell division [GO:2000035]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0001228; GO:0005634; GO:0005654; GO:0006357; GO:0016604; GO:0043409; GO:0045944; GO:0090263; GO:1990841; GO:2000035
GN009293	GN009293.1	Q6P0I8	40.5	210	256	271	1.22e-50	169	EXOS6_DANRE	Exosome complex component MTR3 (Exosome component 6) (mRNA transport regulator 3 homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	nuclear mRNA surveillance [GO:0071028]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; rRNA catabolic process [GO:0016075]; U4 snRNA 3'-end processing [GO:0034475]	RNA binding [GO:0003723]	cytoplasmic exosome (RNase complex) [GO:0000177]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]	GO:0000176; GO:0000177; GO:0000178; GO:0003723; GO:0005730; GO:0016075; GO:0034475; GO:0071028; GO:0071051
GN009294	GN009294.1	Q8N3Y7	54.6	282	308	309	6.62e-103	306	RDHE2_HUMAN	Epidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5)	Homo sapiens (Human)	keratinocyte proliferation [GO:0043616]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572]	all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	GO:0000122; GO:0000785; GO:0003714; GO:0004745; GO:0005634; GO:0005789; GO:0005811; GO:0017053; GO:0042572; GO:0042574; GO:0043616; GO:0045814; GO:0061629; GO:0140297
GN009296	GN009296.1	Q15428	82.9	234	337	464	3.01e-133	390	SF3A2_HUMAN	Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62)	Homo sapiens (Human)	mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of neuron projection development [GO:0010976]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]	GO:0000245; GO:0000387; GO:0000389; GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005684; GO:0005686; GO:0006397; GO:0008270; GO:0010976; GO:0016607; GO:0071004; GO:0071005; GO:0071006; GO:0071011; GO:0071013; GO:1903241
GN009298	GN009298.1	B7Z0W9	31.0	593	794	1576	6.05e-74	266	OTOP_DROME	Proton channel OtopLc (Otopetrin-Lc) (DmOtopLc)	Drosophila melanogaster (Fruit fly)	proton transmembrane transport [GO:1902600]	proton channel activity [GO:0015252]	plasma membrane [GO:0005886]	GO:0005886; GO:0015252; GO:1902600
GN009313	GN009313.1	P46197	77.9	113	122	1047	3.93e-54	184	ANPRB_BOVIN	Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B)	Bos taurus (Bovine)	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; identical protein binding [GO:0042802]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; protein kinase activity [GO:0004672]	plasma membrane [GO:0005886]	GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0006182; GO:0007168; GO:0016941; GO:0017046; GO:0035556; GO:0042802
GN009316	GN009316.1	A7UXI1	34.3	166	159	613	3.55e-13	69.3	CAO2_NEUCR	Carotenoid dioxygenase (EC 1.13.11.59)	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)		oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]	cytosol [GO:0005829]	GO:0005829; GO:0016702
GN009321	GN009321.1	Q91XT5	28.1	335	357	566	4.55e-17	85.9	BCDO1_RAT	Beta,beta-carotene 15,15'-dioxygenase (EC 1.13.11.63) (Beta-carotene dioxygenase 1) (Beta-carotene oxygenase 1)	Rattus norvegicus (Rat)	beta-carotene metabolic process [GO:1901810]; carotene catabolic process [GO:0016121]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]	beta-carotene 15,15'-dioxygenase activity [GO:0003834]	cytosol [GO:0005829]	GO:0001523; GO:0003834; GO:0005829; GO:0016121; GO:0042572; GO:0042574; GO:1901810
GN009324	GN009324.1	A6NHR9	41.4	1986	1739	2005	0.0	1431	SMHD1_HUMAN	Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-)	Homo sapiens (Human)	chromosome organization [GO:0051276]; dosage compensation by inactivation of X chromosome [GO:0009048]; double-strand break repair [GO:0006302]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; nose development [GO:0043584]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein homodimerization activity [GO:0042803]	Barr body [GO:0001740]; chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]	GO:0001740; GO:0005524; GO:0005654; GO:0005694; GO:0006302; GO:0009048; GO:0016604; GO:0016887; GO:0035861; GO:0042803; GO:0043584; GO:0045739; GO:0051276; GO:2000042; GO:2001034
GN009331	GN009331.1	Q3UKC1	33.3	75	106	814	8.83e-09	54.7	TAXB1_MOUSE	Tax1-binding protein 1 homolog	Mus musculus (Mouse)	cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein K48-linked ubiquitination [GO:0070936]; protein localization to phagocytic vesicle [GO:1905161]; toll-like receptor 4 signaling pathway [GO:0034142]	kinase binding [GO:0019900]; protein-macromolecule adaptor activity [GO:0030674]; signaling adaptor activity [GO:0035591]; ubiquitin binding [GO:0043130]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407]	GO:0000407; GO:0002753; GO:0005737; GO:0005739; GO:0005776; GO:0010804; GO:0019900; GO:0030674; GO:0034142; GO:0034144; GO:0035591; GO:0039532; GO:0043066; GO:0043124; GO:0043130; GO:0070936; GO:1905161; GO:2000660
GN009335	GN009335.1	P00179	37.6	492	483	487	1.57e-98	308	CP2C5_RABIT	Cytochrome P450 2C5 (EC 1.14.14.1) (CYPIIC5) (Cytochrome P450 1) (Cytochrome P450IIC5) (Progesterone 21-hydroxylase)	Oryctolagus cuniculus (Rabbit)	xenobiotic metabolic process [GO:0006805]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005789; GO:0006805; GO:0016712; GO:0020037
GN009336	GN009336.1	Q08BH7	66.7	153	205	194	5.03e-76	229	UBE2T_DANRE	Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]	chromatin binding [GO:0003682]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]	nucleus [GO:0005634]	GO:0000209; GO:0003682; GO:0004842; GO:0005634; GO:0006281; GO:0006513; GO:0006974; GO:0051865; GO:0061631
GN009339	GN009339.1	H2A0M7	43.0	589	1253	793	1.41e-127	415	PLSP_PINMG	Peroxidase-like protein	Margaritifera margaritifera (Freshwater pearl mussel)	response to oxidative stress [GO:0006979]	heme binding [GO:0020037]; peroxidase activity [GO:0004601]	extracellular region [GO:0005576]	GO:0004601; GO:0005576; GO:0006979; GO:0020037
GN009340	GN009340.1	P86856	34.2	231	211	321	9.84e-32	120	MANL_MYTCA	Nacrein-like protein	Mytilus californianus (California mussel)	one-carbon metabolic process [GO:0006730]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0004089; GO:0005576; GO:0006730; GO:0008270
GN009353	GN009353.1	Q9M2U3	26.7	311	370	406	8.35e-26	110	ALPL_ARATH	Protein ALP1-like (EC 3.1.-.-)	Arabidopsis thaliana (Mouse-ear cress)			histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634
GN009355	GN009355.1	Q6MG64	26.1	590	1011	892	1.00e-27	124	VWA7_RAT	von Willebrand factor A domain-containing protein 7 (Protein G7c)	Rattus norvegicus (Rat)			extracellular region [GO:0005576]	GO:0005576
GN009356	GN009356.1	Q6MG64	28.1	690	1030	892	4.38e-43	173	VWA7_RAT	von Willebrand factor A domain-containing protein 7 (Protein G7c)	Rattus norvegicus (Rat)			extracellular region [GO:0005576]	GO:0005576
GN009357	GN009357.1	O43704	36.2	265	307	296	1.05e-38	141	ST1B1_HUMAN	Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase)	Homo sapiens (Human)	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004062; GO:0005737; GO:0005829; GO:0006068; GO:0006576; GO:0006805; GO:0008146; GO:0009812; GO:0018958; GO:0030855; GO:0042403; GO:0050427; GO:0051923
GN009358	GN009358.1	Q95JD5	33.7	285	324	296	3.03e-39	143	ST1B1_CANLF	Sulfotransferase 1B1 (ST1B1) (cSULT1B1) (EC 2.8.2.1) (Sulfotransferase family cytosolic 1B member 1)	Canis lupus familiaris (Dog) (Canis familiaris)	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	aryl sulfotransferase activity [GO:0004062]	cytoplasm [GO:0005737]	GO:0004062; GO:0005737; GO:0006068; GO:0006805; GO:0009812; GO:0030855; GO:0042403; GO:0050427; GO:0051923
GN009361	GN009361.1	Q6ZQ38	70.6	987	983	1230	0.0	1321	CAND1_MOUSE	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1)	Mus musculus (Mouse)	cell differentiation [GO:0030154]; negative regulation of catalytic activity [GO:0043086]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265]	TBP-class protein binding [GO:0017025]	cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0010265; GO:0016567; GO:0017025; GO:0030154; GO:0031461; GO:0043086; GO:0045893; GO:0045899
GN009362	GN009362.1	A7MBJ5	58.9	168	184	1230	8.65e-46	164	CAND1_BOVIN	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1)	Bos taurus (Bovine)	protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265]		cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0010265; GO:0016567; GO:0031461
GN009363	GN009363.1	Q9NV58	60.6	563	837	838	1.74e-213	628	RN19A_HUMAN	E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38)	Homo sapiens (Human)	microtubule cytoskeleton organization [GO:0000226]; protein ubiquitination [GO:0016567]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000226; GO:0005813; GO:0005829; GO:0008270; GO:0016020; GO:0016567; GO:0031624; GO:0061630
GN009364	GN009364.1	Q9C509	38.7	504	536	544	1.80e-115	355	SGPL_ARATH	Sphingosine-1-phosphate lyase (AtSPL1) (S1PL) (SP-lyase) (SPL) (EC 4.1.2.27) (Dihydrosphingosine phosphate lyase 1) (AtDPL1) (Sphingosine-1-phosphate aldolase)	Arabidopsis thaliana (Mouse-ear cress)	sphingolipid catabolic process [GO:0030149]	pyridoxal phosphate binding [GO:0030170]; sphinganine-1-phosphate aldolase activity [GO:0008117]	chloroplast [GO:0009507]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0008117; GO:0009507; GO:0030149; GO:0030170
GN009365	GN009365.1	Q8K078	49.0	625	752	723	2.47e-185	548	SO4A1_MOUSE	Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12)	Mus musculus (Mouse)	sodium-independent organic anion transport [GO:0043252]; thyroid hormone metabolic process [GO:0042403]; transmembrane transport [GO:0055085]	prostaglandin transmembrane transporter activity [GO:0015132]; thyroid hormone transmembrane transporter activity [GO:0015349]; transmembrane transporter activity [GO:0022857]	basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; plasma membrane [GO:0005886]	GO:0005886; GO:0015132; GO:0015349; GO:0016323; GO:0022857; GO:0030054; GO:0042403; GO:0043252; GO:0055085
GN009366	GN009366.1	Q5G268	58.4	101	779	875	1.08e-30	133	NETR_NOMLE	Neurotrypsin (EC 3.4.21.-) (Serine protease 12)	Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)	exocytosis [GO:0006887]; proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]	axon [GO:0030424]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0004252; GO:0005576; GO:0005886; GO:0006508; GO:0006887; GO:0030424; GO:0098793; GO:0098978
GN009371	GN009371.1	P70365	44.5	346	1806	1447	2.43e-64	246	NCOA1_MOUSE	Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Nuclear receptor coactivator protein 1) (mNRC-1) (Steroid receptor coactivator 1) (SRC-1)	Mus musculus (Mouse)	cellular response to hormone stimulus [GO:0032870]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; estrogen receptor signaling pathway [GO:0030520]; estrous cycle [GO:0044849]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; labyrinthine layer morphogenesis [GO:0060713]; lactation [GO:0007595]; male gonad development [GO:0008584]; male mating behavior [GO:0060179]; mRNA transcription by RNA polymerase II [GO:0042789]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of female receptivity [GO:0045925]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by galactose [GO:0000435]; progesterone receptor signaling pathway [GO:0050847]; regulation of cellular response to insulin stimulus [GO:1900076]; regulation of thyroid hormone receptor signaling pathway [GO:0002155]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; protein dimerization activity [GO:0046983]; protein-containing complex binding [GO:0044877]; protein-lysine-acetyltransferase activity [GO:0061733]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	GO:0000435; GO:0000785; GO:0000977; GO:0002155; GO:0003677; GO:0003682; GO:0003713; GO:0005634; GO:0005654; GO:0005667; GO:0005829; GO:0005886; GO:0007595; GO:0008584; GO:0016922; GO:0021549; GO:0021766; GO:0021854; GO:0021987; GO:0030331; GO:0030520; GO:0032355; GO:0032526; GO:0032570; GO:0032870; GO:0032991; GO:0035357; GO:0042789; GO:0042974; GO:0043065; GO:0044849; GO:0044877; GO:0045666; GO:0045893; GO:0045925; GO:0045944; GO:0046965; GO:0046983; GO:0050847; GO:0060179; GO:0060713; GO:0061733; GO:0090575; GO:1900076; GO:1904017; GO:1904179
GN009373	GN009373.1	Q9UHR5	47.8	226	325	308	8.22e-52	176	S30BP_HUMAN	SAP30-binding protein (Transcriptional regulator protein HCNGP)	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]; regulation of mRNA splicing, via spliceosome [GO:0048024]; response to virus [GO:0009615]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0006355; GO:0009615; GO:0016538; GO:0016607; GO:0048024
GN009376	GN009376.1	Q7M6Z5	41.0	1294	1402	1394	3.52e-271	815	KIF27_RAT	Kinesin-like protein KIF27	Rattus norvegicus (Rat)	cilium assembly [GO:0060271]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; ventricular system development [GO:0021591]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	cilium [GO:0005929]; extracellular region [GO:0005576]; kinesin complex [GO:0005871]	GO:0003351; GO:0003777; GO:0005524; GO:0005576; GO:0005871; GO:0005929; GO:0008017; GO:0021591; GO:0060271
GN009377	GN009377.1	Q8T880	40.3	658	721	737	2.23e-132	411	DNAI7_CIOIN	Dynein axonemal intermediate chain 7 homolog (Axonemal 84 kDa protein) (Ci-AXP83.9) (p83.9)	Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)		beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]	axoneme [GO:0005930]	GO:0005930; GO:0008017; GO:0048487
GN009378	GN009378.1	P79955	46.4	605	691	643	6.58e-130	401	CTK2_XENLA	Carboxy-terminal kinesin 2 (XCTK2)	Xenopus laevis (African clawed frog)	microtubule-based movement [GO:0007018]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	cytoskeleton [GO:0005856]	GO:0003777; GO:0005524; GO:0005856; GO:0007018; GO:0008017
GN009380	GN009380.1	Q969R8	48.3	362	344	447	9.18e-104	315	ITFG2_HUMAN	KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2)	Homo sapiens (Human)	cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; negative regulation of TORC1 signaling [GO:1904262]; regulation of TOR signaling [GO:0032006]		cytosol [GO:0005829]; KICSTOR complex [GO:0140007]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005765; GO:0005829; GO:0032006; GO:0034198; GO:0042149; GO:0140007; GO:1904262
GN009383	GN009383.1	Q14444	31.5	308	562	709	1.02e-33	139	CAPR1_HUMAN	Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105)	Homo sapiens (Human)	membraneless organelle assembly [GO:0140694]; negative regulation of translation [GO:0017148]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of stress granule assembly [GO:0062029]; regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0106288]	ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; molecular function activator activity [GO:0140677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling adaptor activity [GO:0035591]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membraneless organelle [GO:0043232]; lamellipodium [GO:0030027]; membrane [GO:0016020]; P-body [GO:0000932]; synapse [GO:0045202]	GO:0000932; GO:0003723; GO:0003729; GO:0005524; GO:0005737; GO:0005829; GO:0010494; GO:0016020; GO:0017148; GO:0030027; GO:0030425; GO:0031252; GO:0035591; GO:0043232; GO:0045202; GO:0050775; GO:0061003; GO:0062029; GO:0106288; GO:0140677; GO:0140693; GO:0140694
GN009385	GN009385.1	Q09660	30.2	484	523	489	1.13e-67	229	CC44_CAEEL	Probable cytochrome P450 CYP44 (EC 1.14.-.-)	Caenorhabditis elegans		heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]		GO:0004497; GO:0005506; GO:0016705; GO:0020037
GN009386	GN009386.1	E1BUG7	52.9	104	718	690	2.84e-16	86.7	SPT2_CHICK	Protein SPT2 homolog	Gallus gallus (Chicken)	heterochromatin formation [GO:0031507]; nucleosome assembly [GO:0006334]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase I [GO:0006360]	DNA binding [GO:0003677]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; RNA polymerase I core binding [GO:0001042]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0001042; GO:0003677; GO:0005654; GO:0005730; GO:0006334; GO:0006355; GO:0006360; GO:0031507; GO:0042393; GO:0140713
GN009390	GN009390.1	Q9NR21	27.1	325	568	338	5.16e-22	100	PAR11_HUMAN	Protein mono-ADP-ribosyltransferase PARP11 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 11) (ARTD11) (Poly [ADP-ribose] polymerase 11) (PARP-11)	Homo sapiens (Human)	protein auto-ADP-ribosylation [GO:0070213]	NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]	nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003950; GO:0005634; GO:0005635; GO:0005643; GO:0005654; GO:0016604; GO:0070213; GO:0140803; GO:0140804; GO:0140806; GO:0140807; GO:1990404
GN009391	GN009391.1	Q3UY23	28.5	618	553	622	4.45e-63	221	FDXA1_MOUSE	Ferredoxin-fold anticodon-binding domain-containing protein 1 homolog (FDX-ACDB domain-containing protein 1)	Mus musculus (Mouse)	rRNA base methylation [GO:0070475]	rRNA (uridine-N3-)-methyltransferase activity [GO:0070042]		GO:0070042; GO:0070475
GN009392	GN009392.1	Q9ULL5	25.6	180	1346	2036	2.02e-14	82.8	PRR12_HUMAN	Proline-rich protein 12	Homo sapiens (Human)	intracellular protein localization [GO:0008104]		nucleus [GO:0005634]; postsynaptic density [GO:0014069]	GO:0005634; GO:0008104; GO:0014069
GN009393	GN009393.1	Q5M9G3	34.1	358	613	707	7.42e-47	179	CAPR1_RAT	Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (RNA granule protein 105)	Rattus norvegicus (Rat)	generation of neurons [GO:0048699]; intracellular mRNA localization [GO:0008298]; membraneless organelle assembly [GO:0140694]; negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of stress granule assembly [GO:0062029]; regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0106288]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]	ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; molecular function activator activity [GO:0140677]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; signaling adaptor activity [GO:0035591]	cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; P-body [GO:0000932]; postsynapse [GO:0098794]; synapse [GO:0045202]	GO:0000932; GO:0003723; GO:0003729; GO:0005524; GO:0005737; GO:0005829; GO:0007399; GO:0007416; GO:0008298; GO:0010494; GO:0017148; GO:0030027; GO:0030425; GO:0031252; GO:0035591; GO:0045202; GO:0048699; GO:0050775; GO:0050808; GO:0061003; GO:0062029; GO:0098794; GO:0098978; GO:0106288; GO:0140677; GO:0140693; GO:0140694
GN009394	GN009394.1	D3YZI9	32.2	121	251	523	6.73e-09	59.3	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN009407	GN009407.1	P35295	35.3	218	211	233	4.26e-38	134	RAB20_MOUSE	Ras-related protein Rab-20 (EC 3.6.5.2)	Mus musculus (Mouse)	cellular response to type II interferon [GO:0071346]; endocytosis [GO:0006897]; phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; Golgi apparatus [GO:0005794]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005525; GO:0005769; GO:0005794; GO:0005886; GO:0006897; GO:0030139; GO:0030670; GO:0045335; GO:0071346; GO:0090383; GO:0090385
GN009412	GN009412.1	Q9JHA8	29.0	594	951	891	6.50e-39	160	VWA7_MOUSE	von Willebrand factor A domain-containing protein 7 (Protein G7c)	Mus musculus (Mouse)			extracellular region [GO:0005576]	GO:0005576
GN009415	GN009415.1	Q68FL6	59.8	388	474	902	7.95e-152	457	SYMC_MOUSE	Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)	Mus musculus (Mouse)	cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; homocysteine metabolic process [GO:0050667]; methionyl-tRNA aminoacylation [GO:0006431]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; rRNA transcription [GO:0009303]	ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; sperm end piece [GO:0097229]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0004825; GO:0005524; GO:0005730; GO:0005737; GO:0005739; GO:0005829; GO:0006431; GO:0009303; GO:0017101; GO:0036120; GO:0050667; GO:0071364; GO:0097225; GO:0097228; GO:0097229; GO:1901838
GN009417	GN009417.1	A0A9J7F5X6	67.5	209	249	900	3.31e-101	317	SYMC_CRIGR	Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	methionyl-tRNA aminoacylation [GO:0006431]	ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytosol [GO:0005829]; nucleolus [GO:0005730]	GO:0004825; GO:0005524; GO:0005730; GO:0005829; GO:0006431; GO:0017101
GN009418	GN009418.1	Q6PF21	31.3	211	279	905	2.30e-24	105	SYMC_XENLA	Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)	Xenopus laevis (African clawed frog)	methionyl-tRNA aminoacylation [GO:0006431]	ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytosol [GO:0005829]; nucleolus [GO:0005730]	GO:0004825; GO:0005524; GO:0005730; GO:0005829; GO:0006431; GO:0017101
GN009419	GN009419.1	Q5CZC0	43.0	107	1990	6907	8.93e-16	88.2	FSIP2_HUMAN	Fibrous sheath-interacting protein 2	Homo sapiens (Human)	flagellated sperm motility [GO:0030317]; protein localization to cilium [GO:0061512]; sperm axoneme assembly [GO:0007288]		sperm end piece [GO:0097229]; sperm head-tail coupling apparatus [GO:0120212]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0007288; GO:0030317; GO:0061512; GO:0097225; GO:0097228; GO:0097229; GO:0120212
GN009422	GN009422.1	Q8N7N6	33.3	123	147	555	2.80e-14	72.0	CIKS_MOUSE	E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)	Mus musculus (Mouse)	B cell affinity maturation [GO:0002344]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell mediated immunity [GO:0019724]; CD40 signaling pathway [GO:0023035]; cellular response to cytokine stimulus [GO:0071345]; cellular response to interleukin-17 [GO:0097398]; cytokine-mediated signaling pathway [GO:0019221]; eosinophil homeostasis [GO:1990959]; eosinophil mediated immunity [GO:0002447]; establishment of T cell polarity [GO:0001768]; gene expression [GO:0010467]; heart development [GO:0007507]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response [GO:0006954]; interleukin-17-mediated signaling pathway [GO:0097400]; interleukin-17A-mediated signaling pathway [GO:0038173]; kidney development [GO:0001822]; lymph node development [GO:0048535]; mRNA stabilization [GO:0048255]; mucus secretion [GO:0070254]; negative regulation of interleukin-17-mediated signaling pathway [GO:1903882]; neutrophil activation [GO:0042119]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of defense response to virus by host [GO:0002230]; protein import into nucleus [GO:0006606]; protein K63-linked ubiquitination [GO:0070534]; protein localization to nucleus [GO:0034504]; protein localization to P-body [GO:0110012]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to cytokine [GO:0034097]; response to xenobiotic stimulus [GO:0009410]; skin development [GO:0043588]; spleen development [GO:0048536]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T-helper 17 type immune response [GO:0072538]; transitional two stage B cell differentiation [GO:0002334]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type 2 immune response [GO:0042092]	signaling receptor binding [GO:0005102]; ubiquitin protein ligase activity [GO:0061630]	cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]	GO:0000209; GO:0001768; GO:0001782; GO:0001783; GO:0001822; GO:0002230; GO:0002334; GO:0002344; GO:0002447; GO:0005102; GO:0005634; GO:0006606; GO:0006954; GO:0006955; GO:0006959; GO:0007507; GO:0009410; GO:0010467; GO:0016567; GO:0019221; GO:0019724; GO:0023035; GO:0030217; GO:0031410; GO:0033209; GO:0034097; GO:0034504; GO:0038173; GO:0042092; GO:0042110; GO:0042119; GO:0043123; GO:0043588; GO:0048255; GO:0048535; GO:0048536; GO:0061630; GO:0070254; GO:0070534; GO:0071345; GO:0072538; GO:0097398; GO:0097400; GO:0110012; GO:1903882; GO:1990959
GN009424	GN009424.1	Q3ZC01	77.7	273	297	285	6.57e-152	429	CNOT7_BOVIN	CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (CCR4-associated factor 1) (CAF-1)	Bos taurus (Bovine)	deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; defense response to virus [GO:0051607]; miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; piRNA-mediated gene silencing by mRNA destabilization [GO:0140991]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of viral genome replication [GO:0045070]; regulatory ncRNA-mediated gene silencing [GO:0031047]	3'-5'-RNA exonuclease activity [GO:0000175]; DNA-binding transcription factor binding [GO:0140297]; piRNA binding [GO:0034584]; poly(A)-specific ribonuclease activity [GO:0004535]; RNA exonuclease activity [GO:0004532]; transcription corepressor activity [GO:0003714]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; P-body [GO:0000932]	GO:0000175; GO:0000289; GO:0000290; GO:0000932; GO:0003714; GO:0004532; GO:0004535; GO:0005634; GO:0008284; GO:0008285; GO:0016607; GO:0030014; GO:0030015; GO:0031047; GO:0034584; GO:0035279; GO:0045070; GO:0051607; GO:0060213; GO:0060339; GO:0140297; GO:0140991; GO:1900153
GN009426	GN009426.1	Q9VZW5	27.9	312	399	549	2.02e-26	114	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN009427	GN009427.1	Q8TAQ2	61.4	971	1067	1214	0.0	993	SMRC2_HUMAN	SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; nucleosome disassembly [GO:0006337]; positive regulation of cell differentiation [GO:0045597]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	ATP-dependent chromatin remodeler activity [GO:0140658]; histone binding [GO:0042393]; transcription coactivator activity [GO:0003713]	bBAF complex [GO:0140092]; brahma complex [GO:0035060]; chromatin [GO:0000785]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	GO:0000776; GO:0000785; GO:0003713; GO:0005654; GO:0006337; GO:0006338; GO:0006357; GO:0016363; GO:0016514; GO:0016586; GO:0030071; GO:0032991; GO:0035060; GO:0042393; GO:0045582; GO:0045597; GO:0045663; GO:0045892; GO:0045893; GO:0070316; GO:0071564; GO:0071565; GO:0140092; GO:0140658; GO:2000045; GO:2000781; GO:2000819
GN009430	GN009430.1	P38766	36.5	307	389	723	2.31e-45	169	RRM3_YEAST	ATP-dependent DNA helicase RRM3 (EC 5.6.2.3) (DNA 5'-3' helicase RRM3) (Regulation of Ty1 transposition protein 104) (rDNA recombination mutation protein 3)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	DNA repair [GO:0006281]; DNA replication [GO:0006260]; replication fork progression beyond termination site [GO:0097046]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; centromeric DNA binding [GO:0019237]; DNA helicase activity [GO:0003678]; G-quadruplex DNA binding [GO:0051880]; single-stranded DNA binding [GO:0003697]	chromosome, telomeric region [GO:0000781]; mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; replication fork [GO:0005657]	GO:0000723; GO:0000781; GO:0003678; GO:0003697; GO:0005524; GO:0005657; GO:0005739; GO:0006260; GO:0006281; GO:0016887; GO:0019237; GO:0043139; GO:0043596; GO:0051880; GO:0071932; GO:0097046
GN009432	GN009432.1	Q01622	93.8	81	243	429	8.09e-42	150	HLOX2_HELRO	Homeobox protein LOX2	Helobdella robusta (Californian leech)	anterior/posterior pattern specification [GO:0009952]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0009952
GN009433	GN009433.1	Q9TT89	53.2	139	284	217	5.73e-35	128	HXB7_BOVIN	Homeobox protein Hox-B7	Bos taurus (Bovine)	anterior/posterior pattern specification [GO:0009952]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0009952
GN009443	GN009443.1	Q9IA11	78.8	85	258	252	2.49e-35	129	HXD5_HETFR	Homeobox protein Hox-D5	Heterodontus francisci (Horn shark) (Cestracion francisci)	anterior/posterior pattern specification [GO:0009952]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0009952
GN009444	GN009444.1	Q1KKS8	45.6	237	247	233	1.23e-50	168	HXD4A_TAKRU	Homeobox protein Hox-D4a	Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)	anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]; positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]	GO:0000978; GO:0000981; GO:0005654; GO:0009952; GO:0045944; GO:0048704
GN009445	GN009445.1	Q1KL12	54.4	149	393	417	1.88e-35	137	HXA3A_TAKRU	Homeobox protein Hox-A3a	Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)	anterior/posterior pattern specification [GO:0009952]; embryonic skeletal system morphogenesis [GO:0048704]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0009952; GO:0048704
GN009449	GN009449.1	P09022	49.4	172	294	331	5.30e-35	132	HXA1_MOUSE	Homeobox protein Hox-A1 (Early retinoic acid 1) (Homeobox protein Hox-1.6) (Homeoboxless protein ERA-1-399) (Homeotic protein ERA-1-993)	Mus musculus (Mouse)	abducens nerve formation [GO:0021599]; anatomical structure formation involved in morphogenesis [GO:0048646]; anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; artery morphogenesis [GO:0048844]; cellular response to ethanol [GO:0071361]; cellular response to retinoic acid [GO:0071300]; central nervous system neuron differentiation [GO:0021953]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; cognition [GO:0050890]; embryonic neurocranium morphogenesis [GO:0048702]; facial nerve structural organization [GO:0021612]; facial nucleus development [GO:0021754]; hindbrain development [GO:0030902]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; motor neuron axon guidance [GO:0008045]; nervous system development [GO:0007399]; neuromuscular process [GO:0050905]; optokinetic behavior [GO:0007634]; outer ear morphogenesis [GO:0042473]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of behavior [GO:0050795]; regulation of transcription by RNA polymerase II [GO:0006357]; rhombomere 3 development [GO:0021569]; rhombomere 4 development [GO:0021570]; rhombomere 5 development [GO:0021571]; semicircular canal formation [GO:0060876]; sensory perception of sound [GO:0007605]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0005654; GO:0006357; GO:0007399; GO:0007605; GO:0007634; GO:0008045; GO:0009653; GO:0009952; GO:0021569; GO:0021570; GO:0021571; GO:0021599; GO:0021612; GO:0021754; GO:0021953; GO:0030902; GO:0042472; GO:0042473; GO:0042802; GO:0043565; GO:0045944; GO:0048646; GO:0048702; GO:0048839; GO:0048844; GO:0050795; GO:0050890; GO:0050905; GO:0060840; GO:0060876; GO:0071300; GO:0071361; GO:0090102; GO:0090103; GO:1990837
GN009453	GN009453.1	A0A8V0YZK7	28.9	225	340	438	6.83e-09	60.5	NMUR1_CHICK	Neuromedin-U receptor 1 (NMU-R1) (G protein-coupled receptor 66) (G protein-coupled receptor FM-3)	Gallus gallus (Chicken)	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcium-mediated signaling [GO:0019722]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium-mediated signaling [GO:0050850]	neuromedin U binding [GO:0042924]; neuromedin U receptor activity [GO:0001607]; neuropeptide receptor activity [GO:0008188]	plasma membrane [GO:0005886]	GO:0001607; GO:0005886; GO:0007193; GO:0007200; GO:0007218; GO:0008188; GO:0019722; GO:0042924; GO:0050850
GN009455	GN009455.1	Q6DFC8	31.6	548	519	498	5.11e-49	179	ZN395_XENLA	Zinc finger protein 395	Xenopus laevis (African clawed frog)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000978; GO:0003700; GO:0005634; GO:0005737; GO:0006357
GN009456	GN009456.1	Q4FZV0	42.4	907	921	881	3.13e-251	729	MANBA_RAT	Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase)	Rattus norvegicus (Rat)	carbohydrate metabolic process [GO:0005975]; glycoprotein catabolic process [GO:0006516]	beta-mannosidase activity [GO:0004567]; D-mannose binding [GO:0005537]; hydrolase activity [GO:0016787]	extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0004567; GO:0005537; GO:0005576; GO:0005764; GO:0005975; GO:0006516; GO:0016787
GN009458	GN009458.1	Q5E9E1	45.3	86	85	328	1.44e-13	67.0	PDLI1_BOVIN	PDZ and LIM domain protein 1 (Elfin)	Bos taurus (Bovine)	actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]; regulation of DNA-templated transcription [GO:0006355]	actin binding [GO:0003779]; muscle alpha-actinin binding [GO:0051371]; transcription coactivator activity [GO:0003713]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; filamentous actin [GO:0031941]; stress fiber [GO:0001725]; transcription regulator complex [GO:0005667]; Z disc [GO:0030018]	GO:0001725; GO:0003713; GO:0003779; GO:0005667; GO:0005737; GO:0005912; GO:0006355; GO:0007507; GO:0030018; GO:0030036; GO:0031941; GO:0051371; GO:0061061
GN009460	GN009460.1	A2VDW9	41.7	103	956	509	6.67e-16	85.5	IKZF3_BOVIN	Zinc finger protein Aiolos (Ikaros family zinc finger protein 3)	Bos taurus (Bovine)	B cell differentiation [GO:0030183]; regulation of apoptotic process [GO:0042981]; regulation of B cell differentiation [GO:0045577]; regulation of B cell proliferation [GO:0030888]; regulation of lymphocyte differentiation [GO:0045619]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell differentiation [GO:0030217]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000978; GO:0001228; GO:0003700; GO:0005634; GO:0005737; GO:0006357; GO:0030183; GO:0030217; GO:0030888; GO:0042803; GO:0042981; GO:0043565; GO:0045577; GO:0045619; GO:0046982
GN009463	GN009463.1	Q3SXD3	58.2	182	185	199	7.71e-69	211	HDDC2_MOUSE	5'-deoxynucleotidase HDDC2 (EC 3.1.3.89) (HD domain-containing protein 2)	Mus musculus (Mouse)	deoxyribonucleoside monophosphate catabolic process [GO:0009159]	5'-deoxynucleotidase activity [GO:0002953]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0002953; GO:0005737; GO:0005739; GO:0009159
GN009464	GN009464.1	Q9CY16	43.6	110	193	186	9.15e-23	93.2	RT28_MOUSE	Small ribosomal subunit protein bS1m (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt)	Mus musculus (Mouse)	mitochondrial translation [GO:0032543]		mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0005763; GO:0032543
GN009465	GN009465.1	Q29043	29.1	302	319	365	7.51e-32	125	FUT1_PIG	Galactoside alpha-(1,2)-fucosyltransferase 1 (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1) (EC 2.4.1.344)	Sus scrofa (Pig)	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; olfactory bulb development [GO:0021772]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell-matrix adhesion [GO:1904906]; positive regulation of sprouting angiogenesis [GO:1903672]; protein O-linked glycosylation via fucose [GO:0036066]	alpha-(1,2)-fucosyltransferase activity [GO:0031127]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]	GO:0001954; GO:0005794; GO:0005975; GO:0008107; GO:0009101; GO:0010595; GO:0021772; GO:0031127; GO:0032580; GO:0036066; GO:1903672; GO:1904906
GN009467	GN009467.1	Q58715	26.2	508	538	492	2.93e-39	152	Y1319_METJA	Uncharacterized sodium-dependent transporter MJ1319	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)	sodium ion transmembrane transport [GO:0035725]		plasma membrane [GO:0005886]	GO:0005886; GO:0035725
GN009468	GN009468.1	P46209	35.7	182	234	231	6.64e-24	98.6	USF_AQUPY	Protein usf	Aquifex pyrophilus		hydrolase activity [GO:0016787]		GO:0016787
GN009472	GN009472.1	Q5ZK10	46.4	211	259	369	3.07e-50	171	NSF1C_CHICK	NSFL1 cofactor p47 (p97 cofactor p47)	Gallus gallus (Chicken)	autophagosome assembly [GO:0000045]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of protein localization to centrosome [GO:1904780]; nuclear membrane reassembly [GO:0031468]; positive regulation of mitotic centrosome separation [GO:0046604]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin binding [GO:0043130]	centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi stack [GO:0005795]; nucleus [GO:0005634]; VCP-NSFL1C complex [GO:1990730]	GO:0000045; GO:0000132; GO:0005634; GO:0005795; GO:0005813; GO:0005829; GO:0007030; GO:0031468; GO:0043130; GO:0043161; GO:0046604; GO:0061025; GO:1904780; GO:1990730
GN009473	GN009473.1	P18075	37.5	421	415	431	9.42e-91	283	BMP7_HUMAN	Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)	Homo sapiens (Human)	allantois development [GO:1905069]; BMP signaling pathway [GO:0030509]; cardiac muscle tissue development [GO:0048738]; cardiac septum morphogenesis [GO:0060411]; cellular response to BMP stimulus [GO:0071773]; cellular response to hypoxia [GO:0071456]; chorio-allantoic fusion [GO:0060710]; dendrite development [GO:0016358]; endocardial cushion formation [GO:0003272]; epithelial to mesenchymal transition [GO:0001837]; eye development [GO:0001654]; heart development [GO:0007507]; heart trabecula morphogenesis [GO:0061384]; hindbrain development [GO:0030902]; mesenchymal cell differentiation [GO:0048762]; mesenchyme development [GO:0060485]; mesonephros development [GO:0001823]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; metanephric mesenchyme morphogenesis [GO:0072133]; metanephros development [GO:0001656]; monocyte aggregation [GO:0070487]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of glomerular mesangial cell proliferation [GO:0072125]; negative regulation of mitotic nuclear division [GO:0045839]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neural fold elevation formation [GO:0021502]; neuron projection morphogenesis [GO:0048812]; osteoblast differentiation [GO:0001649]; pericardium morphogenesis [GO:0003344]; pharyngeal system development [GO:0060037]; positive regulation of bone mineralization [GO:0030501]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of dendrite development [GO:1900006]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of hyaluranon cable assembly [GO:1900106]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of removal of superoxide radicals [GO:2000121]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]; response to vitamin D [GO:0033280]; skeletal system development [GO:0001501]; ureteric bud development [GO:0001657]	BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; vesicle [GO:0031982]	GO:0001501; GO:0001649; GO:0001654; GO:0001656; GO:0001657; GO:0001823; GO:0001837; GO:0003272; GO:0003344; GO:0005125; GO:0005576; GO:0007507; GO:0008083; GO:0008201; GO:0010628; GO:0010664; GO:0010718; GO:0016358; GO:0021502; GO:0030501; GO:0030509; GO:0030902; GO:0031012; GO:0031982; GO:0032355; GO:0033280; GO:0034116; GO:0043434; GO:0045665; GO:0045669; GO:0045786; GO:0045839; GO:0045892; GO:0045893; GO:0048738; GO:0048762; GO:0048812; GO:0060037; GO:0060391; GO:0060411; GO:0060485; GO:0060710; GO:0061384; GO:0070487; GO:0070700; GO:0071456; GO:0071773; GO:0072125; GO:0072133; GO:0072134; GO:0072136; GO:0090336; GO:1900006; GO:1900106; GO:1901223; GO:1905069; GO:1905312; GO:2000121
GN009474	GN009474.1	Q5F477	42.1	311	307	324	5.85e-84	258	LDAH_CHICK	Lipid droplet-associated hydrolase (EC 3.1.1.13) (Lipid droplet-associated serine hydrolase)	Gallus gallus (Chicken)	cholesterol homeostasis [GO:0042632]; intracellular triglyceride homeostasis [GO:0035356]; lipid droplet fusion [GO:0160077]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]	sterol ester esterase activity [GO:0004771]	endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]	GO:0004771; GO:0005783; GO:0005811; GO:0019915; GO:0034389; GO:0035356; GO:0042632; GO:0160077
GN009475	GN009475.1	Q9Z1G4	65.0	838	831	839	0.0	1068	VPP1_MOUSE	V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)	Mus musculus (Mouse)	regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; nuclear speck [GO:0016607]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	GO:0000220; GO:0005737; GO:0005794; GO:0005829; GO:0005886; GO:0007035; GO:0016020; GO:0016241; GO:0016471; GO:0016607; GO:0030665; GO:0030672; GO:0042470; GO:0046961; GO:0048471; GO:0051117; GO:0097401
GN009476	GN009476.1	Q7JK24	32.9	255	321	326	2.15e-48	167	B3GT1_GORGO	Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)	Gorilla gorilla gorilla (Western lowland gorilla)	glucosylceramide metabolic process [GO:0006678]; glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006678; GO:0008499; GO:0009101; GO:0009312
GN009478	GN009478.1	Q86Z23	35.6	118	287	238	4.70e-10	62.0	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN009484	GN009484.1	G5EBQ8	37.6	692	1286	1668	4.61e-110	384	CHS2_CAEEL	Chitin synthase chs-2 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase chs-2)	Caenorhabditis elegans	chitin biosynthetic process [GO:0006031]; positive regulation of nematode larval development [GO:0061063]	chitin synthase activity [GO:0004100]	plasma membrane [GO:0005886]	GO:0004100; GO:0005886; GO:0006031; GO:0061063
GN009485	GN009485.1	P11172	54.4	471	483	480	3.83e-179	513	UMPS_HUMAN	Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)]	Homo sapiens (Human)	'de novo' CTP biosynthetic process [GO:0044210]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; pyrimidine nucleobase biosynthetic process [GO:0019856]; UDP biosynthetic process [GO:0006225]; UMP biosynthetic process [GO:0006222]	identical protein binding [GO:0042802]; orotate phosphoribosyltransferase activity [GO:0004588]; orotidine-5'-phosphate decarboxylase activity [GO:0004590]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004588; GO:0004590; GO:0005634; GO:0005737; GO:0005829; GO:0006207; GO:0006222; GO:0006225; GO:0019856; GO:0042802; GO:0044205; GO:0044210
GN009486	GN009486.1	Q1JQ91	73.9	119	129	142	1.01e-51	163	RPB4_BOVIN	DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D)	Bos taurus (Bovine)	transcription initiation at RNA polymerase II promoter [GO:0006367]	nucleotide binding [GO:0000166]; translation initiation factor binding [GO:0031369]	nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]	GO:0000166; GO:0005634; GO:0005665; GO:0006367; GO:0031369
GN009490	GN009490.1	Q3T0V4	74.8	159	157	158	4.30e-80	236	RS11_BOVIN	Small ribosomal subunit protein uS17 (40S ribosomal protein S11)	Bos taurus (Bovine)	ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic small ribosomal subunit [GO:0022627]; small-subunit processome [GO:0032040]	GO:0003735; GO:0005737; GO:0006412; GO:0022627; GO:0032040; GO:0042274
GN009492	GN009492.1	Q7T3B2	33.3	126	186	144	4.18e-18	79.7	HRG1A_DANRE	Heme transporter hrg1-A (zHRG-1) (Heme-responsive gene 1 protein homolog A) (HRG-1A) (Solute carrier family 48 member 1-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	erythrocyte development [GO:0048821]; heme transport [GO:0015886]	heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]	endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	GO:0005764; GO:0005765; GO:0005886; GO:0010008; GO:0015232; GO:0015886; GO:0020037; GO:0030670; GO:0048821
GN009493	GN009493.1	O95394	55.4	536	549	542	6.28e-203	579	AGM1_HUMAN	Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; D-glucosamine metabolic process [GO:0006041]; hemopoiesis [GO:0030097]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	magnesium ion binding [GO:0000287]; phosphoacetylglucosamine mutase activity [GO:0004610]	cytosol [GO:0005829]	GO:0000287; GO:0004610; GO:0005829; GO:0005975; GO:0006041; GO:0006048; GO:0006487; GO:0006493; GO:0030097
GN009494	GN009494.1	B0BNF8	44.1	220	232	242	4.02e-58	187	HTAI2_RAT	Protein HTATIP2	Rattus norvegicus (Rat)	positive regulation of programmed cell death [GO:0043068]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]	protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0004674; GO:0005737; GO:0005739; GO:0005829; GO:0043068; GO:0045944; GO:0046777
GN009496	GN009496.1	Q14191	30.4	438	457	1432	1.76e-40	158	WRN_HUMAN	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Homo sapiens (Human)	base-excision repair [GO:0006284]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; mismatch repair [GO:0006298]; positive regulation of strand invasion [GO:0098530]; protein localization to nucleolus [GO:1902570]; replication fork processing [GO:0031297]; response to UV-C [GO:0010225]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; 3'-flap-structured DNA binding [GO:0070337]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bubble DNA binding [GO:0000405]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; exonuclease activity [GO:0004527]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MutLalpha complex binding [GO:0032405]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]	centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000287; GO:0000400; GO:0000403; GO:0000405; GO:0000723; GO:0000731; GO:0000781; GO:0003677; GO:0003678; GO:0004527; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005730; GO:0005737; GO:0005813; GO:0006259; GO:0006260; GO:0006284; GO:0006298; GO:0006302; GO:0006310; GO:0006974; GO:0008408; GO:0009267; GO:0009378; GO:0010225; GO:0016607; GO:0016887; GO:0030145; GO:0031297; GO:0032201; GO:0032392; GO:0032405; GO:0042803; GO:0043138; GO:0044877; GO:0051880; GO:0061749; GO:0061820; GO:0061821; GO:0061849; GO:0070337; GO:0071480; GO:0090398; GO:0090656; GO:0098530; GO:1902570; GO:1905773
GN009503	GN009503.1	Q8TDV5	27.9	251	337	335	1.18e-15	80.1	GP119_HUMAN	Glucose-dependent insulinotropic receptor (G protein-coupled receptor 119)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]	G protein-coupled receptor activity [GO:0004930]; phosphatidylcholine binding [GO:0031210]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004930; GO:0005737; GO:0005886; GO:0007189; GO:0031210; GO:0043235
GN009504	GN009504.1	Q9JIQ3	27.5	167	270	237	1.81e-09	60.1	DBLOH_MOUSE	Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]	Mus musculus (Mouse)	apoptotic signaling pathway [GO:0097190]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]		CD40 receptor complex [GO:0035631]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; sperm end piece [GO:0097229]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0005737; GO:0005739; GO:0005758; GO:0005814; GO:0005829; GO:0008631; GO:0009898; GO:0035631; GO:0043065; GO:0051402; GO:0097190; GO:0097193; GO:0097225; GO:0097228; GO:0097229
GN009505	GN009505.1	Q9Y2P5	47.6	189	189	690	7.87e-54	184	S27A5_HUMAN	Long-chain fatty acid transport protein 5 (FATP-5) (Fatty acid transport protein 5) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Bile acyl-CoA synthetase) (BACS) (EC 6.2.1.7) (Cholate--CoA ligase) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (EC 6.2.1.-) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)	Homo sapiens (Human)	bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; very long-chain fatty acid metabolic process [GO:0000038]	cholate-CoA ligase activity [GO:0047747]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; protein-containing complex binding [GO:0044877]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	basal plasma membrane [GO:0009925]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GO:0000038; GO:0001676; GO:0004467; GO:0005324; GO:0005783; GO:0005789; GO:0005886; GO:0006699; GO:0008206; GO:0009925; GO:0015721; GO:0031957; GO:0032991; GO:0044539; GO:0044877; GO:0047747
GN009506	GN009506.1	O14975	38.9	607	627	620	1.82e-143	433	S27A2_HUMAN	Long-chain fatty acid transport protein 2 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Phytanate--CoA ligase) (EC 6.2.1.24) (Solute carrier family 27 member 2) (THCA-CoA ligase) (EC 6.2.1.7) (Very long-chain acyl-CoA synthetase) (VLACS) (VLCS) (EC 6.2.1.-) (Very long-chain-fatty-acid-CoA ligase)	Homo sapiens (Human)	bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty-acyl-CoA biosynthetic process [GO:0046949]; long-chain fatty acid import into cell [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; methyl-branched fatty acid metabolic process [GO:0097089]	arachidonate-CoA ligase activity [GO:0047676]; cholate-CoA ligase activity [GO:0047747]; enzyme binding [GO:0019899]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; phytanate-CoA ligase activity [GO:0050197]; pristanate-CoA ligase activity [GO:0070251]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]	GO:0001561; GO:0001676; GO:0004467; GO:0005324; GO:0005778; GO:0005788; GO:0005789; GO:0005829; GO:0005886; GO:0006635; GO:0006699; GO:0008206; GO:0019899; GO:0031957; GO:0033540; GO:0035579; GO:0044539; GO:0046949; GO:0047676; GO:0047747; GO:0050197; GO:0070062; GO:0070251; GO:0097089
GN009509	GN009509.1	Q4WBR2	30.9	459	473	488	8.29e-62	212	NEG1_ASPFU	Endo-1,6-beta-D-glucanase neg1 (EC 3.2.1.75) (Beta-1,6-glucanase neg1) (Glucan endo-1,6-beta-glucosidase neg1)	Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)	glucosylceramide catabolic process [GO:0006680]	glucan endo-1,6-beta-glucosidase activity [GO:0046557]; glucosylceramidase activity [GO:0004348]	extracellular region [GO:0005576]	GO:0004348; GO:0005576; GO:0006680; GO:0046557
GN009511	GN009511.1	A8E627	43.2	271	276	305	1.09e-65	210	ENDUD_XENLA	Uridylate-specific endoribonuclease D (EC 4.6.1.-) (Protein endoU-D) (XendoU-D)	Xenopus laevis (African clawed frog)		RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]	extracellular region [GO:0005576]	GO:0003723; GO:0004521; GO:0005576
GN009515	GN009515.1	Q9BVI0	24.9	886	1291	1012	1.60e-33	144	PHF20_HUMAN	PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP)	Homo sapiens (Human)	positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]		histone acetyltransferase complex [GO:0000123]; MLL1 complex [GO:0071339]; NSL complex [GO:0044545]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]	GO:0000123; GO:0005654; GO:0006357; GO:0031965; GO:0044545; GO:0045893; GO:0071339
GN009516	GN009516.1	A2VE56	51.3	76	139	316	1.04e-18	83.2	P20L1_BOVIN	PHD finger protein 20-like protein 1	Bos taurus (Bovine)	regulation of DNA-templated transcription [GO:0006355]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0006355
GN009517	GN009517.1	Q9Y6R7	26.7	375	422	5405	9.80e-21	99.0	FCGBP_HUMAN	IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP)	Homo sapiens (Human)		extracellular matrix structural constituent [GO:0005201]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; Golgi lumen [GO:0005796]	GO:0005201; GO:0005796; GO:0031012; GO:0070062
GN009518	GN009518.1	Q9Y6R7	27.1	376	422	5405	7.13e-22	102	FCGBP_HUMAN	IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP)	Homo sapiens (Human)		extracellular matrix structural constituent [GO:0005201]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; Golgi lumen [GO:0005796]	GO:0005201; GO:0005796; GO:0031012; GO:0070062
GN009523	GN009523.1	B3EWZ6	52.9	174	181	7311	3.88e-54	187	MLRP2_ACRMI	MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN009526	GN009526.1	Q58PK4	24.8	436	1451	412	3.26e-21	101	ILE2_BOMOR	Peptidylaminoacyl-L/D-isomerase (EC 5.1.1.21) (Frog skin isomerase)	Bombina orientalis (Oriental fire-bellied toad)				
GN009529	GN009529.1	Q6NTJ3	31.4	876	829	887	7.77e-85	292	GWL_XENLA	Serine/threonine-protein kinase greatwall (GW) (GWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L)	Xenopus laevis (African clawed frog)	DNA damage response [GO:0006974]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular signal transduction [GO:0035556]; mitotic cell cycle [GO:0000278]; protein autophosphorylation [GO:0046777]; regulation of mitotic cell cycle [GO:0007346]	ATP binding [GO:0005524]; protein phosphatase 2A binding [GO:0051721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000086; GO:0000278; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005813; GO:0006974; GO:0007346; GO:0015630; GO:0032154; GO:0035556; GO:0046777; GO:0051721; GO:0106310
GN009533	GN009533.1	Q9WU28	52.9	153	160	154	7.00e-46	150	PFD5_MOUSE	Prefoldin subunit 5 (EIG-1) (Myc modulator 1) (c-Myc-binding protein Mm-1)	Mus musculus (Mouse)	negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; protein folding [GO:0006457]; retina development in camera-type eye [GO:0060041]; RNA polymerase I assembly [GO:1990113]; RNA polymerase II core complex assembly [GO:1990114]; RNA polymerase III assembly [GO:1990115]	amyloid-beta binding [GO:0001540]; unfolded protein holdase activity [GO:0140309]	cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]	GO:0001540; GO:0005634; GO:0005829; GO:0006457; GO:0016272; GO:0045111; GO:0045892; GO:0060041; GO:0090090; GO:0140309; GO:1905907; GO:1990113; GO:1990114; GO:1990115
GN009534	GN009534.1	Q66HA4	44.9	176	951	813	1.35e-36	152	TAXB1_RAT	Tax1-binding protein 1 homolog (Liver regeneration-related protein LRRG004)	Rattus norvegicus (Rat)	negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; negative regulation of interleukin-1-mediated signaling pathway [GO:2000660]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein localization to phagocytic vesicle [GO:1905161]	kinase binding [GO:0019900]; protein-macromolecule adaptor activity [GO:0030674]; signaling adaptor activity [GO:0035591]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; phagophore assembly site [GO:0000407]	GO:0000407; GO:0005737; GO:0005739; GO:0005776; GO:0010804; GO:0019900; GO:0030674; GO:0034144; GO:0035591; GO:0039532; GO:0043066; GO:0043124; GO:1905161; GO:2000660
GN009535	GN009535.1	Q27567	58.5	318	338	350	2.49e-130	379	GPDA_DROEZ	Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)	Drosophila ezoana (Fruit fly)	carbohydrate metabolic process [GO:0005975]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerophospholipid metabolic process [GO:0006650]	glycerol-3-phosphate dehydrogenase (NAD+) activity [GO:0141152]; NAD binding [GO:0051287]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]	GO:0005829; GO:0005975; GO:0006650; GO:0042803; GO:0046168; GO:0051287; GO:0141152
GN009536	GN009536.1	Q1ERI0	30.3	304	334	329	7.63e-31	122	CITB_MONPU	2-oxoglutarate-dependent dioxygenase mpl2 (EC 1.14.-.-) (Citrinin synthesis protein A)	Monascus purpureus (Red mold) (Monascus anka)				
GN009538	GN009538.1	P11024	64.4	1039	1068	1086	0.0	1293	NNTM_BOVIN	NAD(P) transhydrogenase, mitochondrial (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)	Bos taurus (Bovine)	NADPH regeneration [GO:0006740]; reactive oxygen species metabolic process [GO:0072593]	NADP binding [GO:0050661]; oxidoreductase activity [GO:0016491]; proton-translocating NAD(P)+ transhydrogenase activity [GO:0008750]	mitochondrial inner membrane [GO:0005743]	GO:0005743; GO:0006740; GO:0008750; GO:0016491; GO:0050661; GO:0072593
GN009539	GN009539.1	P48735	77.3	427	445	452	1.04e-243	674	IDHP_HUMAN	Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)	Homo sapiens (Human)	2-oxoglutarate metabolic process [GO:0006103]; carbohydrate metabolic process [GO:0005975]; isocitrate metabolic process [GO:0006102]; NADP+ biosynthetic process [GO:0006741]; NADP+ metabolic process [GO:0006739]; negative regulation of glial cell migration [GO:1903976]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of matrix metallopeptidase secretion [GO:1904465]; tricarboxylic acid cycle [GO:0006099]	isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]	GO:0000287; GO:0004450; GO:0005739; GO:0005759; GO:0005777; GO:0005829; GO:0005975; GO:0006099; GO:0006102; GO:0006103; GO:0006739; GO:0006741; GO:0051287; GO:0060253; GO:0070062; GO:1903976; GO:1904465
GN009540	GN009540.1	Q9UHG0	26.4	382	896	476	1.78e-21	102	DCDC2_HUMAN	Doublecortin domain-containing protein 2 (Protein RU2S)	Homo sapiens (Human)	cellular defense response [GO:0006968]; cilium assembly [GO:0060271]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]	kinesin binding [GO:0019894]	axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; kinocilium [GO:0060091]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]	GO:0001764; GO:0005737; GO:0005815; GO:0005874; GO:0005929; GO:0005930; GO:0006968; GO:0007605; GO:0019894; GO:0030111; GO:0035556; GO:0045880; GO:0060091; GO:0060271; GO:0072686; GO:1902017
GN009541	GN009541.1	Q8K4L0	58.1	649	745	874	1.79e-236	684	DDX54_MOUSE	ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (DEAD box protein 54)	Mus musculus (Mouse)	RNA metabolic process [GO:0016070]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nuclear estrogen receptor binding [GO:0030331]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714]	Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003714; GO:0003723; GO:0003724; GO:0005102; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005794; GO:0006364; GO:0006396; GO:0016070; GO:0016887; GO:0030331
GN009544	GN009544.1	Q8K4L0	59.1	611	712	874	1.24e-227	660	DDX54_MOUSE	ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (DEAD box protein 54)	Mus musculus (Mouse)	RNA metabolic process [GO:0016070]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nuclear estrogen receptor binding [GO:0030331]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; signaling receptor binding [GO:0005102]; transcription corepressor activity [GO:0003714]	Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003714; GO:0003723; GO:0003724; GO:0005102; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005794; GO:0006364; GO:0006396; GO:0016070; GO:0016887; GO:0030331
GN009554	GN009554.1	P30568	42.8	250	251	225	2.70e-54	177	GSTA_PLEPL	Glutathione S-transferase A (GST-A) (EC 2.5.1.18) (GST class-theta)	Pleuronectes platessa (European plaice)	glutathione metabolic process [GO:0006749]; L-phenylalanine catabolic process [GO:0006559]	glutathione transferase activity [GO:0004364]; maleylacetoacetate isomerase activity [GO:0016034]	mitochondrion [GO:0005739]	GO:0004364; GO:0005739; GO:0006559; GO:0006749; GO:0016034
GN009555	GN009555.1	P30568	46.1	217	227	225	7.26e-64	201	GSTA_PLEPL	Glutathione S-transferase A (GST-A) (EC 2.5.1.18) (GST class-theta)	Pleuronectes platessa (European plaice)	glutathione metabolic process [GO:0006749]; L-phenylalanine catabolic process [GO:0006559]	glutathione transferase activity [GO:0004364]; maleylacetoacetate isomerase activity [GO:0016034]	mitochondrion [GO:0005739]	GO:0004364; GO:0005739; GO:0006559; GO:0006749; GO:0016034
GN009557	GN009557.1	Q3B8D7	40.7	118	170	177	8.56e-25	97.4	DYL5A_XENLA	Dynein light chain Tctex-type 5-A (Tctex1 domain-containing protein 1-A)	Xenopus laevis (African clawed frog)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505
GN009558	GN009558.1	P78524	36.3	435	1023	1137	2.42e-76	276	DEN2B_HUMAN	DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein)	Homo sapiens (Human)	positive regulation of ERK1 and ERK2 cascade [GO:0070374]	guanyl-nucleotide exchange factor activity [GO:0005085]	cell cortex [GO:0005938]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	GO:0005085; GO:0005886; GO:0005938; GO:0055037; GO:0070374
GN009560	GN009560.1	P12812	21.8	357	417	354	8.41e-11	66.6	P40_SCHMA	Major egg antigen (p40)	Schistosoma mansoni (Blood fluke)	protein refolding [GO:0042026]; response to heat [GO:0009408]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0009408; GO:0042026
GN009561	GN009561.1	A0A1B0GTJ6	30.7	326	334	334	7.60e-36	135	SAXO3_HUMAN	Stabilizer of axonemal microtubules 3	Homo sapiens (Human)				
GN009562	GN009562.1	Q3UE31	40.3	407	421	404	6.74e-72	234	K0930_MOUSE	Uncharacterized protein KIAA0930 homolog	Mus musculus (Mouse)				
GN009564	GN009564.1	Q14191	32.8	323	339	1432	1.11e-33	135	WRN_HUMAN	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Homo sapiens (Human)	base-excision repair [GO:0006284]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; mismatch repair [GO:0006298]; positive regulation of strand invasion [GO:0098530]; protein localization to nucleolus [GO:1902570]; replication fork processing [GO:0031297]; response to UV-C [GO:0010225]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; 3'-flap-structured DNA binding [GO:0070337]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bubble DNA binding [GO:0000405]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; exonuclease activity [GO:0004527]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MutLalpha complex binding [GO:0032405]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]	centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000287; GO:0000400; GO:0000403; GO:0000405; GO:0000723; GO:0000731; GO:0000781; GO:0003677; GO:0003678; GO:0004527; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005730; GO:0005737; GO:0005813; GO:0006259; GO:0006260; GO:0006284; GO:0006298; GO:0006302; GO:0006310; GO:0006974; GO:0008408; GO:0009267; GO:0009378; GO:0010225; GO:0016607; GO:0016887; GO:0030145; GO:0031297; GO:0032201; GO:0032392; GO:0032405; GO:0042803; GO:0043138; GO:0044877; GO:0051880; GO:0061749; GO:0061820; GO:0061821; GO:0061849; GO:0070337; GO:0071480; GO:0090398; GO:0090656; GO:0098530; GO:1902570; GO:1905773
GN009567	GN009567.1	B3EWZ5	37.4	2157	1857	5145	0.0	1349	MLRP1_ACRMI	MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN009568	GN009568.1	P48445	25.6	328	333	690	6.65e-21	97.1	BPL1_YEAST	Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)]	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)		biotin--[biotin carboxyl-carrier protein] ligase activity [GO:0004077]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004077; GO:0005634; GO:0005737
GN009571	GN009571.1	Q8N3X1	39.4	104	599	1017	3.89e-18	92.4	FNBP4_HUMAN	Formin-binding protein 4 (Formin-binding protein 30)	Homo sapiens (Human)			nucleoplasm [GO:0005654]	GO:0005654
GN009577	GN009577.1	Q5HZI9	45.2	263	291	298	7.09e-80	246	S2551_MOUSE	Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 (Mitochondrial NAD(+) transporter SLC25A51) (Mitochondrial carrier triple repeat protein 1) (Solute carrier family 25 member 51)	Mus musculus (Mouse)	aerobic electron transport chain [GO:0019646]; mitochondrial NAD transmembrane transport [GO:1990549]; NAD+ biosynthetic process via the salvage pathway [GO:0034355]	NAD transmembrane transporter activity [GO:0051724]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0019646; GO:0034355; GO:0051724; GO:1990549
GN009579	GN009579.1	P71359	26.4	220	278	619	8.35e-13	71.6	RECQ_HAEIN	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]	GO:0003676; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0009432; GO:0016887; GO:0030894; GO:0043138; GO:0043590
GN009588	GN009588.1	Q8N414	28.1	128	228	524	3.12e-10	62.8	PGBD5_HUMAN	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac domain-related protein 5) (PiggyBac transposase 5)	Homo sapiens (Human)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN009589	GN009589.1	Q13705	68.5	92	103	512	1.13e-37	135	AVR2B_HUMAN	Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)	Homo sapiens (Human)	activin receptor signaling pathway [GO:0032924]; anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; cellular response to growth factor stimulus [GO:0071363]; intracellular iron ion homeostasis [GO:0006879]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of ossification [GO:0030279]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pattern specification process [GO:0007389]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of DNA-templated transcription [GO:0006355]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; trophoblast cell migration [GO:0061450]; venous blood vessel development [GO:0060841]	activin binding [GO:0048185]; activin receptor activity [GO:0017002]; activin receptor activity, type II [GO:0016362]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; kinase activator activity [GO:0019209]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]	activin receptor complex [GO:0048179]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; signaling receptor complex [GO:0043235]	GO:0000122; GO:0001946; GO:0001974; GO:0004674; GO:0004712; GO:0005524; GO:0005737; GO:0005886; GO:0006355; GO:0006879; GO:0007165; GO:0007178; GO:0007389; GO:0009952; GO:0016362; GO:0017002; GO:0019209; GO:0019838; GO:0030279; GO:0030501; GO:0030509; GO:0032924; GO:0032927; GO:0032991; GO:0043235; GO:0045669; GO:0048179; GO:0048185; GO:0060836; GO:0060840; GO:0060841; GO:0061298; GO:0061450; GO:0071363; GO:0120163; GO:1904178
GN009596	GN009596.1	P43332	67.7	235	234	216	3.53e-98	288	SNRPA_DROME	U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A) (Sex determination protein snf)	Drosophila melanogaster (Fruit fly)	female germ-line sex determination [GO:0019099]; mRNA splicing, via spliceosome [GO:0000398]; oogenesis [GO:0048477]; primary sex determination, soma [GO:0007539]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	poly(U) RNA binding [GO:0008266]; pre-mRNA intronic pyrimidine-rich binding [GO:0097158]; snRNA stem-loop binding [GO:0035614]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]	catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; small nuclear ribonucleoprotein complex [GO:0030532]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]	GO:0000381; GO:0000398; GO:0005634; GO:0005685; GO:0005686; GO:0007539; GO:0008266; GO:0008380; GO:0019099; GO:0030532; GO:0030619; GO:0030620; GO:0032991; GO:0035614; GO:0048477; GO:0071011; GO:0071013; GO:0097158; GO:1990904
GN009602	GN009602.1	Q20191	50.3	171	759	450	3.67e-46	174	NAS13_CAEEL	Zinc metalloproteinase nas-13 (EC 3.4.24.-) (Nematode astacin 13)	Caenorhabditis elegans	proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0004222; GO:0005576; GO:0006508; GO:0008270
GN009606	GN009606.1	Q3T0R7	62.8	390	423	397	1.21e-178	506	THIM_BOVIN	3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase)	Bos taurus (Bovine)	fatty acid beta-oxidation [GO:0006635]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]	acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA hydrolase activity [GO:0003986]; fatty acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; medium-chain fatty acyl-CoA hydrolase activity [GO:0052815]; short-chain fatty acyl-CoA hydrolase activity [GO:0141126]	mitochondrion [GO:0005739]	GO:0003985; GO:0003986; GO:0003988; GO:0005739; GO:0006635; GO:0047617; GO:0052815; GO:0052816; GO:0141126; GO:1901029
GN009607	GN009607.1	Q9VVK7	50.1	383	444	569	1.05e-88	283	NUCB_DROME	Nucleobindin [Cleaved into: Nesfatin-1]	Drosophila melanogaster (Fruit fly)	carbohydrate metabolic process [GO:0005975]; defense response to Gram-negative bacterium [GO:0050829]; insemination [GO:0007320]	calcium ion binding [GO:0005509]; hydrolase activity [GO:0016787]	endomembrane system [GO:0012505]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005509; GO:0005576; GO:0005793; GO:0005794; GO:0005975; GO:0007320; GO:0012505; GO:0016787; GO:0050829
GN009608	GN009608.1	C7G0B5	31.2	276	402	1007	2.06e-37	147	PIF_PINFU	Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)]	Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata)		chitin binding [GO:0008061]	extracellular region [GO:0005576]	GO:0005576; GO:0008061
GN009610	GN009610.1	Q20930	30.7	293	1113	509	1.86e-24	112	MIG17_CAEEL	Metalloprotease mig-17 (EC 3.4.24.-) (Abnormal cell migration protein 17)	Caenorhabditis elegans	gonad morphogenesis [GO:0035262]; intracellular protein localization [GO:0008104]; protein autoprocessing [GO:0016540]; regulation of cell migration [GO:0030334]; regulation of distal tip cell migration [GO:1903354]; zymogen activation [GO:0031638]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	basement membrane [GO:0005604]; extracellular region [GO:0005576]	GO:0004222; GO:0005576; GO:0005604; GO:0008104; GO:0008237; GO:0016540; GO:0030334; GO:0031638; GO:0035262; GO:1903354
GN009619	GN009619.1	Q6DHQ1	30.5	131	436	235	1.35e-10	64.7	HVCN1_DANRE	Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; proton transmembrane transport [GO:1902600]; response to zinc ion [GO:0010043]	voltage-gated proton channel activity [GO:0030171]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]	GO:0005886; GO:0008270; GO:0010043; GO:0030171; GO:0071294; GO:0071467; GO:1902600
GN009622	GN009622.1	Q8N0W4	31.5	523	513	816	2.56e-64	226	NLGNX_HUMAN	Neuroligin-4, X-linked (Neuroligin X) (HNLX)	Homo sapiens (Human)	adult behavior [GO:0030534]; brainstem development [GO:0003360]; cell-cell junction organization [GO:0045216]; cerebellum development [GO:0021549]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of excitatory postsynaptic potential [GO:0090394]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; organ growth [GO:0035265]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; regulation of synapse assembly [GO:0051963]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; vocalization behavior [GO:0071625]	cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; chloride ion binding [GO:0031404]; neurexin family protein binding [GO:0042043]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]	asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic specialization membrane [GO:0099634]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]	GO:0003360; GO:0005886; GO:0007158; GO:0007416; GO:0007612; GO:0009986; GO:0016020; GO:0021549; GO:0030182; GO:0030425; GO:0030534; GO:0031404; GO:0035176; GO:0035265; GO:0042043; GO:0042803; GO:0043197; GO:0045202; GO:0045216; GO:0050804; GO:0050808; GO:0050839; GO:0051963; GO:0060076; GO:0071625; GO:0090394; GO:0097105; GO:0097110; GO:0098631; GO:0098839; GO:0098978; GO:0098982; GO:0098983; GO:0098985; GO:0099054; GO:0099634
GN009625	GN009625.1	Q5T4F7	42.0	250	392	317	2.33e-63	208	SFRP5_HUMAN	Secreted frizzled-related protein 5 (sFRP-5) (Frizzled-related protein 1b) (FRP-1b) (Secreted apoptosis-related protein 3) (SARP-3)	Homo sapiens (Human)	anatomical structure morphogenesis [GO:0009653]; apoptotic process [GO:0006915]; canonical Wnt signaling pathway [GO:0060070]; digestive tract morphogenesis [GO:0048546]; establishment or maintenance of cell polarity [GO:0007163]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of Wnt signaling pathway [GO:0030178]; non-canonical Wnt signaling pathway [GO:0035567]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; visual perception [GO:0007601]	Wnt-protein binding [GO:0017147]	extracellular region [GO:0005576]	GO:0005576; GO:0006357; GO:0006915; GO:0007163; GO:0007165; GO:0007601; GO:0008285; GO:0009653; GO:0017147; GO:0030178; GO:0035567; GO:0048546; GO:0051898; GO:0060070; GO:0090090; GO:2000051
GN009626	GN009626.1	O96019	67.3	431	421	429	2.96e-203	570	ACL6A_HUMAN	Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; nervous system development [GO:0007399]; neural retina development [GO:0003407]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; telomere maintenance [GO:0000723]	chromatin binding [GO:0003682]; transcription coactivator activity [GO:0003713]	brahma complex [GO:0035060]; chromatin [GO:0000785]; GBAF complex [GO:0140288]; Ino80 complex [GO:0031011]; kinetochore [GO:0000776]; npBAF complex [GO:0071564]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	GO:0000723; GO:0000776; GO:0000785; GO:0000786; GO:0003407; GO:0003682; GO:0003713; GO:0005634; GO:0005654; GO:0005886; GO:0006275; GO:0006338; GO:0006355; GO:0006357; GO:0007165; GO:0007399; GO:0008284; GO:0016363; GO:0016514; GO:0016586; GO:0021510; GO:0030071; GO:0031011; GO:0032991; GO:0033044; GO:0035060; GO:0035267; GO:0042981; GO:0045582; GO:0045596; GO:0045597; GO:0045663; GO:0045893; GO:0045995; GO:0051726; GO:0060382; GO:0070316; GO:0071564; GO:0140288; GO:1902459; GO:1904507; GO:1905168; GO:2000045; GO:2000779; GO:2000781; GO:2000819
GN009628	GN009628.1	O75581	49.4	1485	1453	1613	0.0	984	LRP6_HUMAN	Low-density lipoprotein receptor-related protein 6 (LRP-6)	Homo sapiens (Human)	canonical Wnt signaling pathway [GO:0060070]; cell-cell adhesion [GO:0098609]; cellular response to cholesterol [GO:0071397]; chemical synaptic transmission [GO:0007268]; dopaminergic neuron differentiation [GO:0071542]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; response to peptide hormone [GO:0043434]; Wnt signaling pathway [GO:0016055]	coreceptor activity [GO:0015026]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; kinase inhibitor activity [GO:0019210]; low-density lipoprotein particle receptor activity [GO:0005041]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase inhibitor activity [GO:0030291]; signaling receptor binding [GO:0005102]; toxin transmembrane transporter activity [GO:0019534]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Wnt signalosome [GO:1990909]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]	GO:0005041; GO:0005102; GO:0005109; GO:0005576; GO:0005783; GO:0005886; GO:0007204; GO:0007268; GO:0007399; GO:0009986; GO:0014029; GO:0014033; GO:0015026; GO:0016055; GO:0017147; GO:0019210; GO:0019534; GO:0030291; GO:0031410; GO:0031901; GO:0034392; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043434; GO:0045121; GO:0045202; GO:0045787; GO:0045893; GO:0045944; GO:0060070; GO:0071397; GO:0071542; GO:0072659; GO:0098609; GO:1904948; GO:1990851; GO:1990909
GN009630	GN009630.1	O88572	51.5	165	308	1613	1.41e-45	168	LRP6_MOUSE	Low-density lipoprotein receptor-related protein 6 (LRP-6)	Mus musculus (Mouse)	anterior/posterior pattern specification [GO:0009952]; axis elongation [GO:0003401]; axis elongation involved in somitogenesis [GO:0090245]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion [GO:0098609]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex cell migration [GO:0021795]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; forebrain generation of neurons [GO:0021872]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; gastrulation with mouth forming second [GO:0001702]; generation of neurons [GO:0048699]; heart looping [GO:0001947]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mammary placode formation [GO:0060596]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; Norrin signaling pathway [GO:0110135]; odontogenesis of dentin-containing tooth [GO:0042475]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ossification [GO:0045778]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; regulation of cell development [GO:0060284]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; response to folic acid [GO:0051593]; retina morphogenesis in camera-type eye [GO:0060042]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]	apolipoprotein binding [GO:0034185]; coreceptor activity [GO:0015026]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; kinase inhibitor activity [GO:0019210]; low-density lipoprotein particle receptor activity [GO:0005041]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase inhibitor activity [GO:0030291]; signaling receptor binding [GO:0005102]; toxin transmembrane transporter activity [GO:0019534]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Wnt signalosome [GO:1990909]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]	GO:0001702; GO:0001756; GO:0001843; GO:0001947; GO:0002053; GO:0003344; GO:0003401; GO:0005041; GO:0005102; GO:0005109; GO:0005769; GO:0005783; GO:0005886; GO:0006355; GO:0007204; GO:0007268; GO:0007399; GO:0009880; GO:0009950; GO:0009952; GO:0009986; GO:0010976; GO:0014029; GO:0014033; GO:0015026; GO:0016020; GO:0016055; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021795; GO:0021861; GO:0021872; GO:0021915; GO:0021943; GO:0021987; GO:0030291; GO:0030326; GO:0030900; GO:0030901; GO:0030917; GO:0031410; GO:0034185; GO:0034392; GO:0035108; GO:0035115; GO:0035116; GO:0035261; GO:0036342; GO:0042074; GO:0042127; GO:0042475; GO:0042733; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043065; GO:0045121; GO:0045202; GO:0045599; GO:0045778; GO:0045780; GO:0045787; GO:0045893; GO:0045944; GO:0046849; GO:0048596; GO:0048699; GO:0048705; GO:0050680; GO:0051593; GO:0060021; GO:0060026; GO:0060042; GO:0060059; GO:0060070; GO:0060284; GO:0060325; GO:0060444; GO:0060535; GO:0060596; GO:0060603; GO:0060856; GO:0071397; GO:0071542; GO:0072659; GO:0090009; GO:0090118; GO:0090245; GO:0098609; GO:0110135; GO:1990851; GO:1990909; GO:1990963; GO:2000051
GN009631	GN009631.1	O75581	45.2	263	272	1613	2.12e-64	221	LRP6_HUMAN	Low-density lipoprotein receptor-related protein 6 (LRP-6)	Homo sapiens (Human)	canonical Wnt signaling pathway [GO:0060070]; cell-cell adhesion [GO:0098609]; cellular response to cholesterol [GO:0071397]; chemical synaptic transmission [GO:0007268]; dopaminergic neuron differentiation [GO:0071542]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; response to peptide hormone [GO:0043434]; Wnt signaling pathway [GO:0016055]	coreceptor activity [GO:0015026]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; kinase inhibitor activity [GO:0019210]; low-density lipoprotein particle receptor activity [GO:0005041]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase inhibitor activity [GO:0030291]; signaling receptor binding [GO:0005102]; toxin transmembrane transporter activity [GO:0019534]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Wnt signalosome [GO:1990909]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]	GO:0005041; GO:0005102; GO:0005109; GO:0005576; GO:0005783; GO:0005886; GO:0007204; GO:0007268; GO:0007399; GO:0009986; GO:0014029; GO:0014033; GO:0015026; GO:0016055; GO:0017147; GO:0019210; GO:0019534; GO:0030291; GO:0031410; GO:0031901; GO:0034392; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043434; GO:0045121; GO:0045202; GO:0045787; GO:0045893; GO:0045944; GO:0060070; GO:0071397; GO:0071542; GO:0072659; GO:0098609; GO:1904948; GO:1990851; GO:1990909
GN009634	GN009634.1	Q8BYF6	36.8	193	301	611	2.01e-25	109	SC5A8_MOUSE	Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (Solute carrier family 5 member 8)	Mus musculus (Mouse)	acetate transport [GO:0006846]; chloride transport [GO:0006821]; iodide transport [GO:0015705]; lactate transport [GO:0015727]; monocarboxylic acid transport [GO:0015718]; nicotinate transport [GO:2001142]; nitrate transmembrane transport [GO:0015706]; propanoate transmembrane transport [GO:0015730]; pyruvate transport [GO:0006848]; short-chain fatty acid transmembrane transport [GO:0015913]; sodium ion transport [GO:0006814]	lactate transmembrane transporter activity [GO:0015129]; monocarboxylate:sodium symporter activity [GO:0140161]; nicotinate transmembrane transporter activity [GO:0090416]; organic acid:sodium symporter activity [GO:0005343]; propionate transmembrane transporter activity [GO:0015552]; short-chain fatty acid transmembrane transporter activity [GO:0015636]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; GINS complex [GO:0000811]; plasma membrane [GO:0005886]	GO:0000811; GO:0005343; GO:0005886; GO:0006814; GO:0006821; GO:0006846; GO:0006848; GO:0015129; GO:0015552; GO:0015636; GO:0015705; GO:0015706; GO:0015718; GO:0015727; GO:0015730; GO:0015913; GO:0016324; GO:0031526; GO:0090416; GO:0140161; GO:2001142
GN009635	GN009635.1	Q5BL81	52.7	110	117	620	1.63e-31	119	SC5A8_XENTR	Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (Solute carrier family 5 member 8)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	acetate transport [GO:0006846]; chloride transport [GO:0006821]; iodide transport [GO:0015705]; lactate transport [GO:0015727]; nicotinate transport [GO:2001142]; nitrate transmembrane transport [GO:0015706]; propanoate transmembrane transport [GO:0015730]; pyruvate transport [GO:0006848]; sodium ion transport [GO:0006814]	monocarboxylate:sodium symporter activity [GO:0140161]; organic acid:sodium symporter activity [GO:0005343]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0005343; GO:0005886; GO:0006814; GO:0006821; GO:0006846; GO:0006848; GO:0015705; GO:0015706; GO:0015727; GO:0015730; GO:0016324; GO:0140161; GO:2001142
GN009637	GN009637.1	Q9D306	25.6	399	407	478	1.82e-22	102	MGT4C_MOUSE	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)	Mus musculus (Mouse)	protein N-linked glycosylation [GO:0006487]	acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006487; GO:0008375; GO:0008454
GN009639	GN009639.1	Q9VCZ3	26.1	318	315	508	2.57e-21	97.4	OCTB1_DROME	Octopamine receptor beta-1R (DmOA2) (DmOct-beta-1R)	Drosophila melanogaster (Fruit fly)	adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; negative regulation of synaptic assembly at neuromuscular junction [GO:0045886]; positive regulation of MAPK cascade [GO:0043410]	adrenergic receptor activity [GO:0004935]; octopamine receptor activity [GO:0004989]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004935; GO:0004989; GO:0005886; GO:0007188; GO:0007189; GO:0016020; GO:0043410; GO:0045886; GO:0071880
GN009646	GN009646.1	Q61245	30.8	198	681	1804	8.95e-18	92.0	COBA1_MOUSE	Collagen alpha-1(XI) chain	Mus musculus (Mouse)	cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; collagen fibril organization [GO:0030199]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; embryonic skeletal system morphogenesis [GO:0048704]; endodermal cell differentiation [GO:0035987]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; proteoglycan metabolic process [GO:0006029]; sensory perception of sound [GO:0007605]; skeletal system morphogenesis [GO:0048705]; tendon development [GO:0035989]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visual perception [GO:0007601]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]	collagen trimer [GO:0005581]; collagen type XI trimer [GO:0005592]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0001502; GO:0002063; GO:0003007; GO:0005576; GO:0005581; GO:0005592; GO:0005783; GO:0006029; GO:0007601; GO:0007605; GO:0008201; GO:0030020; GO:0030199; GO:0031012; GO:0035987; GO:0035989; GO:0042472; GO:0048704; GO:0048705; GO:0050910; GO:0051216; GO:0055010; GO:1904399
GN009648	GN009648.1	Q7ZY18	72.3	794	786	825	0.0	1140	MC6ZB_XENLA	Zygotic DNA replication licensing factor mcm6-B (EC 3.6.4.12) (Zygotic minichromosome maintenance protein 6-B) (zMCM6-B) (zMCM6b)	Xenopus laevis (African clawed frog)	DNA replication initiation [GO:0006270]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication [GO:1902969]; premeiotic DNA replication [GO:0006279]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded 3'-5' DNA helicase activity [GO:1990518]; single-stranded DNA binding [GO:0003697]	MCM complex [GO:0042555]; nucleus [GO:0005634]	GO:0000727; GO:0003697; GO:0005524; GO:0005634; GO:0006270; GO:0006279; GO:0016887; GO:0030174; GO:0042555; GO:1902969; GO:1990518
GN009649	GN009649.1	Q6P6R0	48.2	218	246	348	7.46e-62	200	LFG1_RAT	Protein lifeguard 1 (Glutamate [NMDA] receptor-associated protein 1) (NMDA receptor glutamate-binding subunit)	Rattus norvegicus (Rat)	endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of neuron apoptotic process [GO:0043524]	calcium channel activity [GO:0005262]; monoatomic cation channel activity [GO:0005261]; transmembrane transporter binding [GO:0044325]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005261; GO:0005262; GO:0005783; GO:0005789; GO:0005794; GO:0032469; GO:0043524; GO:0044325; GO:1902042; GO:1902236
GN009652	GN009652.1	Q9JHA8	32.1	365	993	891	1.26e-30	134	VWA7_MOUSE	von Willebrand factor A domain-containing protein 7 (Protein G7c)	Mus musculus (Mouse)			extracellular region [GO:0005576]	GO:0005576
GN009653	GN009653.1	Q9JHA8	31.9	432	504	891	6.49e-39	154	VWA7_MOUSE	von Willebrand factor A domain-containing protein 7 (Protein G7c)	Mus musculus (Mouse)			extracellular region [GO:0005576]	GO:0005576
GN009654	GN009654.1	Q9JHA8	30.8	422	1390	891	4.26e-33	142	VWA7_MOUSE	von Willebrand factor A domain-containing protein 7 (Protein G7c)	Mus musculus (Mouse)			extracellular region [GO:0005576]	GO:0005576
GN009657	GN009657.1	O14132	35.6	174	731	650	4.42e-15	82.8	PIT1_SCHPO	Sporulation protein kinase pit1 (EC 2.7.11.1)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	ascospore formation [GO:0030437]; intracellular signal transduction [GO:0035556]; regulation of meiotic nuclear division [GO:0040020]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell division site [GO:0032153]; cytosol [GO:0005829]	GO:0004674; GO:0005524; GO:0005829; GO:0030437; GO:0032153; GO:0035556; GO:0040020; GO:0106310
GN009658	GN009658.1	Q86Z23	33.7	104	126	238	7.74e-11	60.5	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN009661	GN009661.1	Q6SKR2	55.6	216	219	214	2.86e-76	231	HEMK2_MOUSE	Methyltransferase HEMK2 (HemK methyltransferase family member 2) (M.HsaHemK2P) (Lysine N-methyltransferase 9) (EC 2.1.1.-) (Methylarsonite methyltransferase N6AMT1) (EC 2.1.1.-) (Methyltransferase N6AMT1) (Protein N(5)-glutamine methyltransferase) (EC 2.1.1.-)	Mus musculus (Mouse)	arsonoacetate metabolic process [GO:0018872]; methylation [GO:0032259]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of cell growth [GO:0030307]; toxin metabolic process [GO:0009404]; transcription initiation-coupled chromatin remodeling [GO:0045815]	arsenite methyltransferase activity [GO:0030791]; histone H4K12 methyltransferase activity [GO:0140984]; histone methyltransferase activity [GO:0042054]; nucleic acid binding [GO:0003676]; protein methyltransferase activity [GO:0008276]; protein-glutamine N-methyltransferase activity [GO:0036009]; S-adenosyl-L-methionine binding [GO:1904047]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007]	cytoplasm [GO:0005737]; eRF1 methyltransferase complex [GO:0035657]; histone methyltransferase complex [GO:0035097]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0003676; GO:0005634; GO:0005737; GO:0008276; GO:0008757; GO:0009007; GO:0009404; GO:0018872; GO:0030307; GO:0030791; GO:0032259; GO:0032991; GO:0035097; GO:0035657; GO:0036009; GO:0042054; GO:0045814; GO:0045815; GO:0140984; GO:1904047
GN009662	GN009662.1	P07584	34.1	179	346	251	1.05e-17	84.7	ASTA_ASTAS	Astacin (EC 3.4.24.21) (Crayfish small molecule proteinase)	Astacus astacus (Noble crayfish) (Astacus fluviatilis)	cell adhesion [GO:0007155]; fertilization [GO:0009566]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; positive regulation of protein processing [GO:0010954]; prevention of polyspermy [GO:0060468]; proteolysis [GO:0006508]	aspartic-type peptidase activity [GO:0070001]; glutamic-type peptidase activity [GO:0070002]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; zinc ion binding [GO:0008270]	cortical granule [GO:0060473]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004222; GO:0005737; GO:0005886; GO:0006508; GO:0007155; GO:0008233; GO:0008270; GO:0009566; GO:0010954; GO:0060468; GO:0060473; GO:0070001; GO:0070002; GO:2000360
GN009663	GN009663.1	Q6PFY8	20.3	365	842	580	2.91e-09	64.3	TRI45_MOUSE	E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99) (Tripartite motif-containing protein 45)	Mus musculus (Mouse)	bone development [GO:0060348]; inflammatory response [GO:0006954]; negative regulation of inflammatory response [GO:0050728]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006954; GO:0008270; GO:0043161; GO:0045171; GO:0050728; GO:0060348; GO:0061630; GO:0070936
GN009666	GN009666.1	Q5F226	28.2	220	390	4351	6.09e-10	65.1	FAT2_MOUSE	Protocadherin Fat 2 (FAT tumor suppressor homolog 2)	Mus musculus (Mouse)	cell-cell adhesion mediated by cadherin [GO:0044331]; cell-substrate adhesion [GO:0031589]; epithelial cell migration [GO:0010631]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	GO:0005509; GO:0005794; GO:0005886; GO:0005912; GO:0007156; GO:0010631; GO:0031589; GO:0044331; GO:0070161
GN009667	GN009667.1	Q5RFZ7	37.8	180	211	204	7.03e-20	86.7	F167A_DANRE	Protein FAM167A	Danio rerio (Zebrafish) (Brachydanio rerio)				
GN009668	GN009668.1	Q6P1G6	32.4	188	207	215	5.41e-21	89.7	F167A_MOUSE	Protein FAM167A	Mus musculus (Mouse)				
GN009671	GN009671.1	Q14517	23.6	432	921	4588	9.73e-11	70.1	FAT1_HUMAN	Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]	Homo sapiens (Human)	anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; homophilic cell-cell adhesion [GO:0007156]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0005509; GO:0005634; GO:0005829; GO:0005886; GO:0005911; GO:0005912; GO:0005925; GO:0007155; GO:0007156; GO:0007267; GO:0009653; GO:0016477; GO:0044331; GO:0048471; GO:0070062; GO:1904385; GO:1904754
GN009672	GN009672.1	Q6AY39	33.3	261	360	331	1.82e-35	135	B3GL1_RAT	UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (Beta-1,3-GalNAc-T1) (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-GalTase 3) (Beta3Gal-T3) (Beta3GalT3) (b3Gal-T3) (Beta-3-Gx-T3) (Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase) (Globoside synthase) (UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase)	Rattus norvegicus (Rat)	glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity [GO:0047273]; N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0008499; GO:0009101; GO:0009312; GO:0047273
GN009673	GN009673.1	P47787	40.8	71	88	534	2.33e-14	69.7	THAS_PIG	Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)	Sus scrofa (Pig)	icosanoid metabolic process [GO:0006690]; prostaglandin biosynthetic process [GO:0001516]	12-hydroxyheptadecatrienoic acid synthase activity [GO:0036134]; heme binding [GO:0020037]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; thromboxane-A synthase activity [GO:0004796]	endoplasmic reticulum membrane [GO:0005789]	GO:0001516; GO:0004497; GO:0004796; GO:0005506; GO:0005789; GO:0006690; GO:0016705; GO:0020037; GO:0036134; GO:0106256
GN009681	GN009681.1	Q9Y6N9	44.6	285	335	552	4.94e-76	246	USH1C_HUMAN	Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein)	Homo sapiens (Human)	actin filament bundle assembly [GO:0051017]; auditory receptor cell morphogenesis [GO:0002093]; brush border assembly [GO:1904970]; equilibrioception [GO:0050957]; G2/M transition of mitotic cell cycle [GO:0000086]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell stereocilium organization [GO:0060122]; parallel actin filament bundle assembly [GO:0030046]; photoreceptor cell maintenance [GO:0045494]; protein localization to microvillus [GO:1904106]; protein-containing complex assembly [GO:0065003]; regulation of microvillus length [GO:0032532]; retinal cone cell development [GO:0046549]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	spectrin binding [GO:0030507]	apical part of cell [GO:0045177]; brush border [GO:0005903]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microvillus [GO:0005902]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; synapse [GO:0045202]	GO:0000086; GO:0001750; GO:0001917; GO:0002093; GO:0002142; GO:0005737; GO:0005829; GO:0005886; GO:0005902; GO:0005903; GO:0005929; GO:0007605; GO:0030046; GO:0030507; GO:0032420; GO:0032426; GO:0032532; GO:0042472; GO:0042491; GO:0045177; GO:0045202; GO:0045494; GO:0046549; GO:0050953; GO:0050957; GO:0051017; GO:0060122; GO:0065003; GO:1904106; GO:1904970
GN009684	GN009684.1	Q01262	28.2	358	1046	690	6.23e-24	112	HYUA_PSESN	Putative D-/L-hydantoinase subunit A (EC 3.5.2.-) (Hydantoin utilization protein A)	Pseudomonas sp. (strain NS671)	glutathione metabolic process [GO:0006749]	5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]	cytosol [GO:0005829]	GO:0005829; GO:0006749; GO:0016810; GO:0017168
GN009685	GN009685.1	Q3ZBR6	77.6	67	79	70	8.57e-26	93.2	SEM1_BOVIN	26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Split hand/foot malformation type 1 protein homolog)	Bos taurus (Bovine)	double-strand break repair via homologous recombination [GO:0000724]; mRNA export from nucleus [GO:0006406]; proteasome assembly [GO:0043248]		cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]	GO:0000502; GO:0000724; GO:0005634; GO:0005829; GO:0006406; GO:0008541; GO:0043248
GN009686	GN009686.1	A0A2B4RNI3	29.1	330	646	688	6.90e-20	97.8	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN009693	GN009693.1	A0A2B4RNI3	32.2	180	646	688	1.21e-19	97.1	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN009694	GN009694.1	A0A2B4RNI3	31.8	192	646	688	9.13e-20	97.4	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN009697	GN009697.1	Q8BFR4	51.3	495	656	544	9.01e-169	496	GNS_MOUSE	N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S)	Mus musculus (Mouse)	glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan catabolic process [GO:0030200]; keratan sulfate proteoglycan catabolic process [GO:0042340]	glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]; sulfate binding [GO:0043199]; sulfuric ester hydrolase activity [GO:0008484]	azurophil granule [GO:0042582]; lysosome [GO:0005764]	GO:0005539; GO:0005764; GO:0008449; GO:0008484; GO:0030200; GO:0030203; GO:0042340; GO:0042582; GO:0043199
GN009698	GN009698.1	Q9UPZ3	33.1	465	1710	1129	5.09e-63	239	HPS5_HUMAN	BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2)	Homo sapiens (Human)	developmental pigmentation [GO:0048066]; melanosome assembly [GO:1903232]; platelet dense granule organization [GO:0060155]		BLOC-2 complex [GO:0031084]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]	GO:0005737; GO:0005769; GO:0005829; GO:0031084; GO:0048066; GO:0060155; GO:1903232
GN009699	GN009699.1	Q2HZX7	42.8	409	432	418	6.68e-107	325	FUZZY_XENTR	Protein fuzzy homolog (Xfy)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cilium assembly [GO:0060271]; embryonic body morphogenesis [GO:0010172]; embryonic skeletal system morphogenesis [GO:0048704]; establishment of planar polarity [GO:0001736]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; regulation of smoothened signaling pathway [GO:0008589]; vesicle-mediated transport [GO:0016192]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	GO:0001736; GO:0001843; GO:0005737; GO:0005856; GO:0008589; GO:0010172; GO:0016192; GO:0048704; GO:0060271; GO:1905515
GN009704	GN009704.1	Q9M2U3	25.6	312	356	406	2.04e-21	97.8	ALPL_ARATH	Protein ALP1-like (EC 3.1.-.-)	Arabidopsis thaliana (Mouse-ear cress)			histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634
GN009705	GN009705.1	Q6B9X6	29.7	172	321	625	4.64e-14	76.3	VWKA_DICDI	Alpha-protein kinase vwkA (EC 2.7.11.1) (von Willebrand factor A alpha-kinase) (vWF kinase)	Dictyostelium discoideum (Social amoeba)	contractile vacuole discharge [GO:0070177]; contractile vacuole organization [GO:0033298]; hypotonic response [GO:0006971]; mitotic cytokinesis [GO:0000281]; myosin II filament organization [GO:0031038]; regulation of sorocarp development [GO:0031156]; sorocarp morphogenesis [GO:0031288]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	contractile vacuolar membrane [GO:0031164]; contractile vacuole [GO:0000331]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]	GO:0000281; GO:0000331; GO:0004672; GO:0004674; GO:0005516; GO:0005524; GO:0005737; GO:0005829; GO:0006971; GO:0031038; GO:0031156; GO:0031164; GO:0031288; GO:0033298; GO:0048471; GO:0070177; GO:0106310
GN009706	GN009706.1	Q5UQ35	28.5	193	321	990	1.86e-12	71.6	YR811_MIMIV	Putative ariadne-like RING finger protein R811	Acanthamoeba polyphaga mimivirus (APMV)		transferase activity [GO:0016740]; zinc ion binding [GO:0008270]		GO:0008270; GO:0016740
GN009708	GN009708.1	A7Y2W8	37.1	70	133	633	5.95e-09	56.2	SC6A9_XENLA	Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9)	Xenopus laevis (African clawed frog)	glycine import across plasma membrane [GO:1903804]; neurotransmitter transport [GO:0006836]; regulation of synaptic transmission, glycinergic [GO:0060092]; sodium ion transmembrane transport [GO:0035725]	amino acid:sodium symporter activity [GO:0005283]; glycine:sodium symporter activity [GO:0015375]	plasma membrane [GO:0005886]	GO:0005283; GO:0005886; GO:0006836; GO:0015375; GO:0035725; GO:0060092; GO:1903804
GN009710	GN009710.1	Q4KMZ8	46.3	188	261	207	6.96e-53	173	NKAI1_HUMAN	Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1) (Protein FAM77C)	Homo sapiens (Human)	regulation of sodium ion transport [GO:0002028]	ATPase binding [GO:0051117]	plasma membrane [GO:0005886]	GO:0002028; GO:0005886; GO:0051117
GN009711	GN009711.1	Q15208	72.3	119	143	465	1.17e-49	167	STK38_HUMAN	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)	Homo sapiens (Human)	DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; negative regulation of MAP kinase activity [GO:0043407]; postsynapse organization [GO:0099173]; protein modification process [GO:0036211]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; histone reader activity [GO:0140566]; magnesium ion binding [GO:0000287]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin-like protein reader activity [GO:0140035]; UFM1-modified protein reader activity [GO:0141185]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000077; GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0005829; GO:0006468; GO:0006974; GO:0031435; GO:0035556; GO:0035861; GO:0036211; GO:0043407; GO:0045296; GO:0098978; GO:0099173; GO:0106310; GO:0140035; GO:0140566; GO:0141185
GN009712	GN009712.1	Q99JX1	66.9	118	191	211	1.32e-43	147	TAF11_MOUSE	Transcription initiation factor TFIID subunit 11 (TFIID subunit p30-beta) (Transcription initiation factor TFIID 28 kDa subunit) (TAF(II)28) (TAFII-28) (TAFII28)	Mus musculus (Mouse)	host-mediated activation of viral transcription [GO:0043923]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	DNA binding [GO:0003677]; nuclear thyroid hormone receptor binding [GO:0046966]; nuclear vitamin D receptor binding [GO:0042809]; protein heterodimerization activity [GO:0046982]; TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]	Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]	GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0005669; GO:0005794; GO:0017025; GO:0042789; GO:0042809; GO:0043923; GO:0046966; GO:0046982; GO:0051123; GO:0060261
GN009713	GN009713.1	Q92753	41.2	136	635	470	9.09e-21	99.4	RORB_HUMAN	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)	Homo sapiens (Human)	amacrine cell differentiation [GO:0035881]; cellular response to retinoic acid [GO:0071300]; eye photoreceptor cell development [GO:0042462]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; melatonin receptor activity [GO:0008502]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0004879; GO:0005634; GO:0005654; GO:0006355; GO:0006357; GO:0008270; GO:0008502; GO:0035881; GO:0042462; GO:0042752; GO:0045668; GO:0045892; GO:0045893; GO:0045944; GO:0046548; GO:0046549; GO:0060041; GO:0071300; GO:1990837
GN009714	GN009714.1	Q92753	44.2	104	591	470	2.45e-20	97.8	RORB_HUMAN	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)	Homo sapiens (Human)	amacrine cell differentiation [GO:0035881]; cellular response to retinoic acid [GO:0071300]; eye photoreceptor cell development [GO:0042462]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; melatonin receptor activity [GO:0008502]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0004879; GO:0005634; GO:0005654; GO:0006355; GO:0006357; GO:0008270; GO:0008502; GO:0035881; GO:0042462; GO:0042752; GO:0045668; GO:0045892; GO:0045893; GO:0045944; GO:0046548; GO:0046549; GO:0060041; GO:0071300; GO:1990837
GN009721	GN009721.1	F1QJF4	26.2	443	530	474	2.06e-27	118	RORAB_DANRE	Nuclear receptor ROR-alpha B (Retinoid-related orphan receptor alpha 1) (Retinoid-related orphan receptor-alpha B)	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of transcription by RNA polymerase II [GO:0006357]	nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0000978; GO:0004879; GO:0005634; GO:0006357; GO:0008270
GN009722	GN009722.1	Q8C0E2	82.0	278	349	336	1.13e-166	471	VP26B_MOUSE	Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B)	Mus musculus (Mouse)	cellular response to type II interferon [GO:0071346]; intracellular protein transport [GO:0006886]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; retrograde transport, endosome to Golgi [GO:0042147]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; postsynaptic early endosome [GO:0098842]; postsynaptic recycling endosome [GO:0098837]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]	GO:0005737; GO:0005769; GO:0005770; GO:0005829; GO:0006886; GO:0016020; GO:0030904; GO:0030906; GO:0042147; GO:0045335; GO:0071346; GO:0098696; GO:0098837; GO:0098842; GO:0098978
GN009733	GN009733.1	Q96QG7	53.9	544	539	549	4.45e-212	602	MTMR9_HUMAN	Myotubularin-related protein 9 (Inactive phosphatidylinositol 3-phosphatase 9)	Homo sapiens (Human)	negative regulation of autophagy [GO:0010507]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of phosphatase activity [GO:0010922]; protein stabilization [GO:0050821]; regulation of phosphatidylinositol dephosphorylation [GO:0060304]	phosphatase activator activity [GO:0019211]; protein phosphatase binding [GO:0019903]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; ruffle membrane [GO:0032587]	GO:0005737; GO:0005783; GO:0005829; GO:0006661; GO:0010507; GO:0010922; GO:0019211; GO:0019903; GO:0032587; GO:0032991; GO:0046856; GO:0048471; GO:0050821; GO:0060304
GN009736	GN009736.1	O88319	24.0	313	386	424	1.24e-10	66.2	NTR1_MOUSE	Neurotensin receptor type 1 (NT-R-1) (NTR1)	Mus musculus (Mouse)	adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; cAMP biosynthetic process [GO:0006171]; conditioned place preference [GO:1990708]; D-aspartate import across plasma membrane [GO:0070779]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; inositol phosphate catabolic process [GO:0071545]; L-glutamate import across plasma membrane [GO:0098712]; learning [GO:0007612]; negative regulation of apoptotic process [GO:0043066]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; positive regulation of apoptotic process [GO:0043065]; positive regulation of arachidonate secretion [GO:0090238]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of locomotion [GO:0040017]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of behavioral fear response [GO:2000822]; regulation of inositol trisphosphate biosynthetic process [GO:0032960]; regulation of membrane depolarization [GO:0003254]; regulation of respiratory gaseous exchange [GO:0043576]; response to food [GO:0032094]; response to lipid [GO:0033993]; response to stress [GO:0006950]; temperature homeostasis [GO:0001659]; vocalization behavior [GO:0071625]	G protein-coupled neurotensin receptor activity [GO:0016492]; identical protein binding [GO:0042802]; neuropeptide receptor activity [GO:0008188]; protein-containing complex binding [GO:0044877]	axon [GO:0030424]; axon terminus [GO:0043679]; cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; membrane raft [GO:0045121]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; symmetric synapse [GO:0032280]; terminal bouton [GO:0043195]	GO:0001659; GO:0003085; GO:0003254; GO:0005886; GO:0006171; GO:0006950; GO:0007218; GO:0007612; GO:0008188; GO:0008306; GO:0008344; GO:0009898; GO:0009986; GO:0010628; GO:0014049; GO:0014054; GO:0016492; GO:0030424; GO:0030425; GO:0032094; GO:0032280; GO:0032960; GO:0033993; GO:0040017; GO:0042802; GO:0043025; GO:0043065; GO:0043066; GO:0043195; GO:0043197; GO:0043198; GO:0043204; GO:0043576; GO:0043679; GO:0044309; GO:0044877; GO:0045121; GO:0050965; GO:0051280; GO:0051281; GO:0060732; GO:0070779; GO:0071545; GO:0071625; GO:0090238; GO:0097151; GO:0098712; GO:1990708; GO:2000822; GO:2001259
GN009737	GN009737.1	P05419	36.3	135	169	131	9.85e-22	88.2	CALN_CHICK	Neo-calmodulin (NeoCaM)	Gallus gallus (Chicken)	calcineurin-mediated signaling [GO:0097720]; detection of calcium ion [GO:0005513]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	calcium ion binding [GO:0005509]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; myelin sheath [GO:0043209]; nucleus [GO:0005634]	GO:0005509; GO:0005513; GO:0005634; GO:0005737; GO:0005813; GO:0010880; GO:0043209; GO:0097720
GN009739	GN009739.1	B3EWY9	29.3	754	1352	1594	3.35e-67	254	MLP_ACRMI	Mucin-like protein	Acropora millepora (Staghorn coral) (Heteropora millepora)	cell-matrix adhesion [GO:0007160]	calcium ion binding [GO:0005509]	membrane [GO:0016020]	GO:0005509; GO:0007160; GO:0016020
GN009740	GN009740.1	Q6P949	31.0	84	151	1063	7.72e-11	62.4	PHF2_DANRE	Lysine-specific demethylase phf2 (EC 1.14.11.-) (PHD finger protein 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	brain development [GO:0007420]; chromatin remodeling [GO:0006338]; negative regulation of rDNA heterochromatin formation [GO:0061188]; protein demethylation [GO:0006482]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription initiation-coupled chromatin remodeling [GO:0045815]	histone demethylase activity [GO:0032452]; histone H3K4me3 reader activity [GO:0140002]; histone H3K9 demethylase activity [GO:0032454]; histone H4K20 demethylase activity [GO:0035575]; iron ion binding [GO:0005506]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]	kinetochore [GO:0000776]; nucleolus [GO:0005730]	GO:0000776; GO:0003712; GO:0003713; GO:0005506; GO:0005730; GO:0006338; GO:0006357; GO:0006482; GO:0007420; GO:0008270; GO:0032452; GO:0032454; GO:0035575; GO:0045815; GO:0061188; GO:0140002
GN009743	GN009743.1	Q8N2E2	21.5	804	2154	1590	2.96e-26	122	VWDE_HUMAN	von Willebrand factor D and EGF domain-containing protein	Homo sapiens (Human)		signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]	GO:0005102; GO:0005576; GO:0009986
GN009744	GN009744.1	Q8N2E2	22.6	844	3173	1590	1.42e-25	120	VWDE_HUMAN	von Willebrand factor D and EGF domain-containing protein	Homo sapiens (Human)		signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]	GO:0005102; GO:0005576; GO:0009986
GN009746	GN009746.1	Q6NV04	69.3	616	633	621	3.81e-313	865	HACL2_DANRE	2-hydroxyacyl-CoA lyase 2 (EC 4.1.2.-) (Acetolactate synthase-like protein) (IlvB-like protein)	Danio rerio (Zebrafish) (Brachydanio rerio)	embryonic cranial skeleton morphogenesis [GO:0048701]; fatty acid alpha-oxidation [GO:0001561]	catalytic activity [GO:0003824]; flavin adenine dinucleotide binding [GO:0050660]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976]	acetolactate synthase complex [GO:0005948]; endoplasmic reticulum membrane [GO:0005789]	GO:0000287; GO:0001561; GO:0003824; GO:0005789; GO:0005948; GO:0030976; GO:0048701; GO:0050660
GN009747	GN009747.1	Q5TF39	40.1	177	872	518	7.15e-29	125	S60A2_HUMAN	Solute carrier family 60 member 2 (Major facilitator superfamily domain-containing protein 4B) (Sodium-dependent glucose transporter 1)	Homo sapiens (Human)	D-glucose import across plasma membrane [GO:0098708]	D-glucose:sodium symporter activity [GO:0005412]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]	GO:0005412; GO:0016324; GO:0031526; GO:0098708
GN009748	GN009748.1	P12812	28.3	300	348	354	2.40e-20	94.0	P40_SCHMA	Major egg antigen (p40)	Schistosoma mansoni (Blood fluke)	protein refolding [GO:0042026]; response to heat [GO:0009408]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0009408; GO:0042026
GN009749	GN009749.1	P25067	34.2	114	415	703	6.52e-09	61.6	CO8A2_HUMAN	Collagen alpha-2(VIII) chain (Endothelial collagen)	Homo sapiens (Human)	basement membrane assembly [GO:0070831]; cell-cell adhesion [GO:0098609]; extracellular matrix organization [GO:0030198]	extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein-macromolecule adaptor activity [GO:0030674]	basement membrane [GO:0005604]; collagen type VIII trimer [GO:0005591]; elastic fiber [GO:0071953]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005201; GO:0005576; GO:0005591; GO:0005604; GO:0005788; GO:0030020; GO:0030198; GO:0030674; GO:0031012; GO:0070831; GO:0071953; GO:0098609
GN009753	GN009753.1	Q8K0H7	30.1	551	472	553	2.12e-64	220	S45A3_MOUSE	Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein)	Mus musculus (Mouse)	positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glucose metabolic process [GO:0010907]; regulation of oligodendrocyte differentiation [GO:0048713]; sucrose transport [GO:0015770]	sucrose:proton symporter activity [GO:0008506]	membrane [GO:0016020]	GO:0008506; GO:0010907; GO:0015770; GO:0016020; GO:0045723; GO:0048713
GN009754	GN009754.1	A6QQW0	33.3	237	725	613	2.33e-15	83.6	ZN143_BOVIN	Zinc finger protein 143 (Selenocysteine tRNA gene transcription-activating factor)	Bos taurus (Bovine)	regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromosome [GO:0005694]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0005694; GO:0006355
GN009755	GN009755.1	Q6IMK3	65.0	266	274	273	8.27e-130	372	DJC27_DANRE	DnaJ homolog subfamily C member 27 (Rab and DnaJ domain-containing protein)	Danio rerio (Zebrafish) (Brachydanio rerio)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	nucleus [GO:0005634]	GO:0003924; GO:0005525; GO:0005634
GN009760	GN009760.1	Q8K1R3	71.4	77	79	783	1.72e-27	106	PNPT1_MOUSE	Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)	Mus musculus (Mouse)	cellular response to interferon-beta [GO:0035458]; cellular response to oxidative stress [GO:0034599]; liver regeneration [GO:0097421]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA polyadenylation [GO:0097222]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrion organization [GO:0007005]; mRNA catabolic process [GO:0006402]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; positive regulation of mRNA catabolic process [GO:0061014]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; regulation of cellular respiration [GO:0043457]; regulation of cellular senescence [GO:2000772]; response to cAMP [GO:0051591]; response to growth hormone [GO:0060416]; RNA catabolic process [GO:0006401]; RNA import into mitochondrion [GO:0035927]; rRNA import into mitochondrion [GO:0035928]	3'-5'-RNA exonuclease activity [GO:0000175]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; polyribonucleotide nucleotidyltransferase activity [GO:0004654]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial degradosome [GO:0045025]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribosome [GO:0005840]	GO:0000175; GO:0000957; GO:0000958; GO:0000962; GO:0000964; GO:0000965; GO:0004654; GO:0005737; GO:0005739; GO:0005758; GO:0005759; GO:0005789; GO:0005829; GO:0005840; GO:0006401; GO:0006402; GO:0007005; GO:0008266; GO:0034046; GO:0034599; GO:0035198; GO:0035458; GO:0035927; GO:0035928; GO:0042802; GO:0043457; GO:0045025; GO:0051260; GO:0051591; GO:0060416; GO:0061014; GO:0070207; GO:0071042; GO:0097222; GO:0097421; GO:2000627; GO:2000772
GN009762	GN009762.1	Q5E9A1	71.2	205	210	215	6.78e-80	240	NACA_BOVIN	Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC)	Bos taurus (Bovine)	protein targeting to membrane [GO:0006612]	TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005737; GO:0005854; GO:0006612; GO:0017025
GN009763	GN009763.1	Q9Y296	65.6	215	218	219	2.22e-107	310	TPPC4_HUMAN	Trafficking protein particle complex subunit 4 (Hematopoietic stem/progenitor cell protein 172) (Synbindin) (TRS23 homolog)	Homo sapiens (Human)	autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; dendrite development [GO:0016358]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; vesicle coating [GO:0006901]; vesicle tethering [GO:0099022]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]; vesicle [GO:0031982]	GO:0000139; GO:0005737; GO:0005783; GO:0005795; GO:0005829; GO:0006888; GO:0006901; GO:0006914; GO:0008021; GO:0016358; GO:0030008; GO:0030425; GO:0031982; GO:0045202; GO:0045211; GO:0048208; GO:0048786; GO:0098839; GO:0099022; GO:1990071; GO:1990072
GN009764	GN009764.1	Q32NQ7	44.2	457	487	485	6.91e-119	360	DAAF3_XENLA	Dynein axonemal assembly factor 3	Xenopus laevis (African clawed frog)	axonemal dynein complex assembly [GO:0070286]; motile cilium assembly [GO:0044458]		dynein axonemal particle [GO:0120293]	GO:0044458; GO:0070286; GO:0120293
GN009765	GN009765.1	Q8CI33	46.8	530	469	537	1.30e-146	432	C19L1_MOUSE	Pre-mRNA splicing factor CWF19L1 (CWF19-like protein 1)	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]	RNA lariat debranching enzyme activator activity [GO:0061632]	post-mRNA release spliceosomal complex [GO:0071014]	GO:0000398; GO:0061632; GO:0071014
GN009766	GN009766.1	Q8VDG5	51.1	272	310	311	2.91e-87	266	PPCS_MOUSE	Phosphopantothenate--cysteine ligase (EC 6.3.2.51) (Phosphopantothenoylcysteine synthetase) (PPC synthetase)	Mus musculus (Mouse)	acetyl-CoA biosynthetic process [GO:0006085]; coenzyme A biosynthetic process [GO:0015937]; heart process [GO:0003015]	identical protein binding [GO:0042802]; phosphopantothenate--cysteine ligase activity [GO:0004632]; protein homodimerization activity [GO:0042803]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003015; GO:0004632; GO:0005634; GO:0005737; GO:0006085; GO:0015937; GO:0042802; GO:0042803; GO:1902494
GN009767	GN009767.1	Q13895	61.9	430	442	437	1.10e-174	499	BYST_HUMAN	Bystin	Homo sapiens (Human)	regulation of protein localization to nucleolus [GO:1904749]; ribosome biogenesis [GO:0042254]	RNA binding [GO:0003723]; snoRNA binding [GO:0030515]	apical part of cell [GO:0045177]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]	GO:0003723; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0005829; GO:0016020; GO:0030515; GO:0030688; GO:0042254; GO:0045177; GO:1904749
GN009768	GN009768.1	Q6AYS8	41.9	277	304	298	1.64e-76	238	DHB11_RAT	Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Dehydrogenase/reductase SDR family member 8)	Rattus norvegicus (Rat)	androgen catabolic process [GO:0006710]	estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity [GO:0016229]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; lipid droplet [GO:0005811]	GO:0004303; GO:0005737; GO:0005783; GO:0005811; GO:0006710; GO:0016229; GO:0016616
GN009769	GN009769.1	Q02846	53.0	230	748	1103	2.43e-61	227	GUC2D_HUMAN	Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (CG-E) (Guanylate cyclase 2D, retinal) (Rod outer segment membrane guanylate cyclase) (ROS-GC)	Homo sapiens (Human)	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of opsin-mediated signaling pathway [GO:0022400]; visual perception [GO:0007601]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; signaling receptor activity [GO:0038023]	endoplasmic reticulum membrane [GO:0005789]; nuclear outer membrane [GO:0005640]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; rod photoreceptor disc membrane [GO:0120202]	GO:0001653; GO:0001750; GO:0004383; GO:0004672; GO:0005524; GO:0005640; GO:0005789; GO:0005886; GO:0006182; GO:0007168; GO:0007601; GO:0022400; GO:0035556; GO:0038023; GO:0042622; GO:0042803; GO:0046982; GO:0097381; GO:0120202
GN009771	GN009771.1	A0A345BJN8	29.7	219	347	919	7.62e-24	106	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN009775	GN009775.1	Q3A8Q0	42.8	215	224	191	4.20e-49	162	PDXT_CARHZ	Pyridoxal 5'-phosphate synthase subunit PdxT (EC 4.3.3.6) (Pdx2) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2)	Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)	L-glutamine catabolic process [GO:0006543]; pyridoxal 5'-phosphate biosynthetic process [GO:0042823]; pyridoxine metabolic process [GO:0008614]	glutaminase activity [GO:0004359]; pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity [GO:0036381]	cytosol [GO:0005829]; glutaminase complex [GO:1903600]	GO:0004359; GO:0005829; GO:0006543; GO:0008614; GO:0036381; GO:0042823; GO:1903600
GN009776	GN009776.1	Q8WPW2	71.7	290	422	306	7.35e-143	412	PDX1_SUBDO	Pyridoxal 5'-phosphate synthase subunit SNZERR (PLP synthase subunit SNZERR) (EC 4.3.3.6) (Ethylene response protein) (PDX1)	Suberites domuncula (Sponge)	amino acid metabolic process [GO:0006520]; pyridoxal 5'-phosphate biosynthetic process [GO:0042823]; pyridoxine biosynthetic process [GO:0008615]	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity [GO:0036381]		GO:0006520; GO:0008615; GO:0036381; GO:0042823
GN009779	GN009779.1	Q93075	31.3	163	424	761	1.13e-12	73.6	TATD2_HUMAN	3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2)	Homo sapiens (Human)		hydrolase activity, acting on ester bonds [GO:0016788]	nucleoplasm [GO:0005654]	GO:0005654; GO:0016788
GN009780	GN009780.1	A8Y1P7	54.3	116	191	384	3.26e-37	135	BRE4_CAEBR	Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.244) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)	Caenorhabditis briggsae	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; positive regulation of Notch signaling pathway [GO:0045747]; response to toxic substance [GO:0009636]	N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0005794; GO:0005975; GO:0006688; GO:0009101; GO:0009636; GO:0016020; GO:0033842; GO:0045747
GN009783	GN009783.1	A0A1S6M251	54.9	113	191	388	3.50e-37	135	B4GT5_PIG	Beta-1,4-galactosyltransferase 5 (Beta-1,4-GalTase 5) (Beta4Gal-T5) (b4Gal-T5) (EC 2.4.1.-) (Beta-1,4-GalT II) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5)	Sus scrofa (Pig)	carbohydrate metabolic process [GO:0005975]; central nervous system myelination [GO:0022010]; central nervous system neuron axonogenesis [GO:0021955]; ganglioside biosynthetic process [GO:0001574]; glycoprotein biosynthetic process [GO:0009101]; neuron maturation [GO:0042551]; positive regulation of embryonic development [GO:0040019]; regulation of protein stability [GO:0031647]	N-acetyllactosamine synthase activity [GO:0003945]; UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity [GO:0008489]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; trans-Golgi network [GO:0005802]	GO:0001574; GO:0003945; GO:0005794; GO:0005802; GO:0005975; GO:0008489; GO:0009101; GO:0021955; GO:0022010; GO:0031647; GO:0032580; GO:0040019; GO:0042551
GN009785	GN009785.1	Q9P2Z0	36.8	68	115	257	6.25e-10	57.8	THA10_HUMAN	THAP domain-containing protein 10	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]		GO:0043565
GN009786	GN009786.1	P71359	38.8	139	157	619	1.07e-18	85.1	RECQ_HAEIN	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]	GO:0003676; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0009432; GO:0016887; GO:0030894; GO:0043138; GO:0043590
GN009790	GN009790.1	Q4G163	30.4	92	164	708	1.44e-10	62.0	FBX43_HUMAN	F-box only protein 43 (Endogenous meiotic inhibitor 2)	Homo sapiens (Human)	cellular response to nerve growth factor stimulus [GO:1990090]; negative regulation of cell cycle process [GO:0010948]; negative regulation of meiotic nuclear division [GO:0045835]; protein ubiquitination [GO:0016567]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	zinc ion binding [GO:0008270]	nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005634; GO:0007088; GO:0008270; GO:0010948; GO:0016567; GO:0019005; GO:0031146; GO:0045835; GO:1990090
GN009791	GN009791.1	Q9BSV6	37.9	298	271	310	8.86e-49	166	SEN34_HUMAN	tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34)	Homo sapiens (Human)	tRNA-type intron splice site recognition and cleavage [GO:0000379]	nucleic acid binding [GO:0003676]; tRNA-intron lyase activity [GO:0000213]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214]	GO:0000213; GO:0000214; GO:0000379; GO:0003676; GO:0005654; GO:0005730
GN009792	GN009792.1	Q7ZXZ0	68.0	822	826	806	0.0	1021	MCM3Z_XENLA	Zygotic DNA replication licensing factor mcm3 (EC 3.6.4.12) (Zygotic minichromosome maintenance protein 3) (zMCM3)	Xenopus laevis (African clawed frog)	DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]	chromosome [GO:0005694]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; nucleus [GO:0005634]	GO:0000727; GO:0003697; GO:0005524; GO:0005634; GO:0005694; GO:0006271; GO:0016887; GO:0017116; GO:0030174; GO:0042555; GO:0071162; GO:1902975
GN009794	GN009794.1	P37209	41.5	65	111	88	2.24e-10	55.8	ATIF1_CAEEL	ATPase inhibitor mai-1, mitochondrial (ATP synthase F1 subunit epsilon)	Caenorhabditis elegans		ATPase inhibitor activity [GO:0042030]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0005737; GO:0005739; GO:0042030
GN009795	GN009795.1	Q6DED0	57.5	214	222	373	5.15e-78	241	TR1L1_XENLA	Translocating chain-associated membrane protein 1-like 1	Xenopus laevis (African clawed frog)	protein insertion into ER membrane [GO:0045048]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]		endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0006616; GO:0045048
GN009796	GN009796.1	Q568B7	39.1	453	501	433	1.16e-91	289	QTMAN_DANRE	tRNA-queuosine alpha-mannosyltransferase (QTMAN) (EC 2.4.1.110) (Glycosyltransferase-like domain-containing protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	central nervous system development [GO:0007417]; regulation of translation [GO:0006417]; tRNA modification [GO:0006400]	tRNA-queuosine(34) beta-mannosyltransferase activity [GO:0016438]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0006400; GO:0006417; GO:0007417; GO:0016438
GN009797	GN009797.1	Q61609	44.0	652	565	681	1.33e-150	451	S20A1_MOUSE	Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1)	Mus musculus (Mouse)	biomineral tissue development [GO:0031214]; cell population proliferation [GO:0008283]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; sodium ion transport [GO:0006814]	high-affinity phosphate:sodium symporter activity [GO:0005316]; sodium:phosphate symporter activity [GO:0005436]	plasma membrane [GO:0005886]	GO:0005316; GO:0005436; GO:0005886; GO:0006814; GO:0006817; GO:0008283; GO:0031214; GO:0035435
GN009799	GN009799.1	Q7Z4M0	28.7	181	154	266	4.04e-10	59.7	RE114_HUMAN	Meiotic recombination protein REC114	Homo sapiens (Human)	meiotic DNA double-strand break formation [GO:0042138]; oogenesis [GO:0048477]; spermatogenesis [GO:0007283]		chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]	GO:0000794; GO:0005694; GO:0007283; GO:0042138; GO:0048477
GN009803	GN009803.1	Q96NG3	38.1	226	520	672	1.63e-38	152	ODAD4_HUMAN	Outer dynein arm-docking complex subunit 4 (Tetratricopeptide repeat protein 25) (TPR repeat protein 25)	Homo sapiens (Human)	cilium movement [GO:0003341]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; flagellated sperm motility [GO:0030317]; mucociliary clearance [GO:0120197]; outer dynein arm assembly [GO:0036158]; protein localization to motile cilium [GO:0120229]		9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; outer dynein arm docking complex [GO:0120228]	GO:0003341; GO:0005576; GO:0005737; GO:0005929; GO:0005930; GO:0030317; GO:0036158; GO:0060287; GO:0097728; GO:0097729; GO:0120197; GO:0120228; GO:0120229
GN009804	GN009804.1	Q59E55	38.5	377	650	625	1.00e-50	189	NAB_DROME	NGFI-A-binding protein homolog (dNAB)	Drosophila melanogaster (Fruit fly)	locomotory behavior [GO:0007626]; negative regulation of DNA-templated transcription [GO:0045892]; neuroblast development [GO:0014019]; neuron development [GO:0048666]; regulation of DNA-templated transcription [GO:0006355]; wing disc pattern formation [GO:0035222]	transcription coregulator activity [GO:0003712]	nucleus [GO:0005634]	GO:0003712; GO:0005634; GO:0006355; GO:0007626; GO:0014019; GO:0035222; GO:0045892; GO:0048666
GN009806	GN009806.1	A1A4L0	55.6	387	422	450	3.34e-139	408	SNX4_BOVIN	Sorting nexin-4	Bos taurus (Bovine)	endocytic recycling [GO:0032456]; positive regulation of autophagosome assembly [GO:2000786]; protein transport [GO:0015031]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]	cytoplasmic dynein complex [GO:0005868]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]	GO:0005769; GO:0005868; GO:0005886; GO:0015031; GO:0031201; GO:0031901; GO:0032266; GO:0032456; GO:0035091; GO:2000786
GN009809	GN009809.1	A2AG06	49.8	227	808	965	2.96e-50	194	MEIOC_MOUSE	Meiosis-specific coiled-coil domain-containing protein MEIOC (Meiosis-specific with coiled-coil domain protein)	Mus musculus (Mouse)	chromosome organization involved in meiotic cell cycle [GO:0070192]; double-strand break repair [GO:0006302]; female meiosis I [GO:0007144]; germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; male meiosis I [GO:0007141]; metaphase chromosome alignment [GO:0051310]; mRNA stabilization [GO:0048255]; oocyte development [GO:0048599]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0006302; GO:0007130; GO:0007141; GO:0007144; GO:0007283; GO:0007286; GO:0048255; GO:0048599; GO:0051310; GO:0051729; GO:0070192
GN009810	GN009810.1	Q14674	33.8	557	2320	2120	5.26e-76	286	ESPL1_HUMAN	Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase)	Homo sapiens (Human)	apoptotic process [GO:0006915]; establishment of mitotic spindle localization [GO:0040001]; maintenance of meiotic sister chromatid cohesion [GO:0034090]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; mitotic cytokinesis [GO:0000281]; mitotic sister chromatid segregation [GO:0000070]; mitotic sister chromatid separation [GO:0051306]; negative regulation of sister chromatid cohesion [GO:0045875]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; proteolysis [GO:0006508]	catalytic activity [GO:0003824]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; separase-securin complex [GO:1990520]	GO:0000070; GO:0000281; GO:0003824; GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0006508; GO:0006915; GO:0008234; GO:0034088; GO:0034090; GO:0040001; GO:0045842; GO:0045875; GO:0051306; GO:0072686; GO:1990520
GN009811	GN009811.1	Q5ZKP6	47.6	84	107	357	2.69e-23	94.7	ADA_CHICK	Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)	Gallus gallus (Chicken)	adenosine catabolic process [GO:0006154]; hypoxanthine salvage [GO:0043103]; inosine biosynthetic process [GO:0046103]; negative regulation of adenosine receptor signaling pathway [GO:0060169]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; T cell activation [GO:0042110]	2'-deoxyadenosine deaminase activity [GO:0046936]; adenosine deaminase activity [GO:0004000]; zinc ion binding [GO:0008270]	anchoring junction [GO:0070161]; cytoplasmic vesicle lumen [GO:0060205]; external side of plasma membrane [GO:0009897]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0004000; GO:0005764; GO:0005886; GO:0006154; GO:0008270; GO:0009168; GO:0009897; GO:0042110; GO:0043103; GO:0045187; GO:0046103; GO:0046936; GO:0060169; GO:0060205; GO:0070161
GN009812	GN009812.1	Q8IW92	44.4	615	662	636	2.87e-162	483	GLBL2_HUMAN	Beta-galactosidase-1-like protein 2 (EC 3.2.1.23)	Homo sapiens (Human)	galactose catabolic process [GO:0019388]	beta-galactosidase activity [GO:0004565]	vacuole [GO:0005773]	GO:0004565; GO:0005773; GO:0019388
GN009815	GN009815.1	Q0V7M8	41.0	183	206	211	2.60e-29	111	F167A_BOVIN	Protein FAM167A	Bos taurus (Bovine)				
GN009818	GN009818.1	Q5ZKQ7	65.6	227	228	228	3.45e-97	285	GID8_CHICK	Glucose-induced degradation protein 8 homolog	Gallus gallus (Chicken)	positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0008284; GO:0030054; GO:0030674; GO:0042803; GO:0043161; GO:0090263
GN009819	GN009819.1	Q9C0H5	53.0	462	1081	1083	1.36e-149	478	RHG39_HUMAN	Rho GTPase-activating protein 39	Homo sapiens (Human)	postsynapse organization [GO:0099173]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]	GO:0005096; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0007165; GO:0051056; GO:0098978; GO:0099173
GN009820	GN009820.1	Q86YI8	70.3	74	160	300	2.60e-31	117	PHF13_HUMAN	PHD finger protein 13 (Survival time-associated PHD finger protein in ovarian cancer 1) (SPOC1)	Homo sapiens (Human)	chromosome segregation [GO:0007059]; DNA damage response [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]	chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; histone H3K9me2/3 reader activity [GO:0062072]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000278; GO:0003682; GO:0005634; GO:0005654; GO:0006974; GO:0007059; GO:0007076; GO:0062072; GO:0140463
GN009821	GN009821.1	Q5ZIM6	50.0	320	628	574	1.70e-78	263	AATF_CHICK	Protein AATF (Apoptosis-antagonizing transcription factor)	Gallus gallus (Chicken)			nucleolus [GO:0005730]	GO:0005730
GN009822	GN009822.1	Q9JK81	56.5	338	375	380	4.06e-136	396	MYG1_MOUSE	MYG1 exonuclease (EC 3.1.-.-) (Protein Gamm1)	Mus musculus (Mouse)	locomotory exploration behavior [GO:0035641]; mitochondrial RNA metabolic process [GO:0000959]; mRNA processing [GO:0006397]; rRNA processing [GO:0006364]	3'-5'-RNA exonuclease activity [GO:0000175]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000175; GO:0000959; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005739; GO:0005759; GO:0006364; GO:0006397; GO:0035641
GN009828	GN009828.1	Q9DF60	35.8	296	358	283	8.18e-47	163	MY88A_XENLA	Myeloid differentiation primary response protein MyD88-A (Toll/IL-1 receptor binding protein MyD88-A)	Xenopus laevis (African clawed frog)	defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]	TIR domain binding [GO:0070976]; Toll-like receptor binding [GO:0035325]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0002755; GO:0005737; GO:0005886; GO:0008063; GO:0034142; GO:0035325; GO:0043123; GO:0045087; GO:0050830; GO:0070976
GN009829	GN009829.1	C8BKC7	43.1	144	165	296	1.87e-32	120	MYD88_SHEEP	Myeloid differentiation primary response protein MyD88	Ovis aries (Sheep)	defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 8 signaling pathway [GO:0034158]	cytokine receptor binding [GO:0005126]; TIR domain binding [GO:0070976]; Toll-like receptor binding [GO:0035325]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0002755; GO:0005126; GO:0005634; GO:0005737; GO:0005886; GO:0008063; GO:0032731; GO:0034142; GO:0034158; GO:0035325; GO:0043123; GO:0045087; GO:0050830; GO:0051607; GO:0070976; GO:1900227
GN009830	GN009830.1	C8BKC7	43.1	144	209	296	1.10e-31	119	MYD88_SHEEP	Myeloid differentiation primary response protein MyD88	Ovis aries (Sheep)	defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 8 signaling pathway [GO:0034158]	cytokine receptor binding [GO:0005126]; TIR domain binding [GO:0070976]; Toll-like receptor binding [GO:0035325]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0002755; GO:0005126; GO:0005634; GO:0005737; GO:0005886; GO:0008063; GO:0032731; GO:0034142; GO:0034158; GO:0035325; GO:0043123; GO:0045087; GO:0050830; GO:0051607; GO:0070976; GO:1900227
GN009833	GN009833.1	O14490	44.6	112	894	977	1.08e-21	105	DLGP1_HUMAN	Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)	Homo sapiens (Human)	chemical synaptic transmission [GO:0007268]; modulation of chemical synaptic transmission [GO:0050804]	molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572]	GO:0005886; GO:0007268; GO:0014069; GO:0044877; GO:0050804; GO:0060090; GO:0098978; GO:0099572
GN009834	GN009834.1	C8BKC7	42.1	292	450	296	4.02e-64	211	MYD88_SHEEP	Myeloid differentiation primary response protein MyD88	Ovis aries (Sheep)	defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 8 signaling pathway [GO:0034158]	cytokine receptor binding [GO:0005126]; TIR domain binding [GO:0070976]; Toll-like receptor binding [GO:0035325]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0002755; GO:0005126; GO:0005634; GO:0005737; GO:0005886; GO:0008063; GO:0032731; GO:0034142; GO:0034158; GO:0035325; GO:0043123; GO:0045087; GO:0050830; GO:0051607; GO:0070976; GO:1900227
GN009835	GN009835.1	P35569	45.0	258	1425	1233	9.00e-52	204	IRS1_MOUSE	Insulin receptor substrate 1 (IRS-1)	Mus musculus (Mouse)	cellular response to fatty acid [GO:0071398]; cellular response to insulin stimulus [GO:0032869]; cytokine-mediated signaling pathway [GO:0019221]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; lipid catabolic process [GO:0016042]; mammary gland development [GO:0030879]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of insulin secretion [GO:0046676]; negative regulation of somatostatin secretion [GO:0090275]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell migration [GO:0030335]; positive regulation of D-glucose import across plasma membrane [GO:0046326]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of glucagon secretion [GO:0070094]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; protein localization to nucleus [GO:0034504]; regulation of gene expression [GO:0010468]; response to caffeine [GO:0031000]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]	insulin receptor binding [GO:0005158]; insulin-like growth factor receptor binding [GO:0005159]; phosphatidylinositol 3-kinase activator activity [GO:0141038]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphotyrosine residue binding [GO:0001784]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor complex adaptor activity [GO:0030159]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]	caveola [GO:0005901]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; insulin receptor complex [GO:0005899]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0001784; GO:0002053; GO:0005068; GO:0005080; GO:0005158; GO:0005159; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0005899; GO:0005901; GO:0008286; GO:0010468; GO:0010907; GO:0016042; GO:0019221; GO:0019901; GO:0019904; GO:0030159; GO:0030335; GO:0030674; GO:0030879; GO:0031000; GO:0032000; GO:0032868; GO:0032869; GO:0034504; GO:0035591; GO:0036064; GO:0042169; GO:0042327; GO:0043491; GO:0043548; GO:0044877; GO:0045471; GO:0045725; GO:0046326; GO:0046627; GO:0046628; GO:0046676; GO:0048009; GO:0051897; GO:0070094; GO:0071398; GO:0090275; GO:0141038
GN009837	GN009837.1	Q9VPD5	30.4	276	465	354	1.22e-39	149	MTEF3_DROME	Transcription termination factor 3, mitochondrial (Mitochondrial transcription termination factor 3) (mTerf3)	Drosophila melanogaster (Fruit fly)	mitochondrial large ribosomal subunit assembly [GO:1902775]; mitochondrial ribosome assembly [GO:0061668]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of mitochondrial transcription [GO:1903108]	large ribosomal subunit rRNA binding [GO:0070180]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0045892; GO:0061668; GO:0070180; GO:1902775; GO:1903108
GN009841	GN009841.1	B7Z0W9	34.7	597	876	1576	1.11e-77	280	OTOP_DROME	Proton channel OtopLc (Otopetrin-Lc) (DmOtopLc)	Drosophila melanogaster (Fruit fly)	proton transmembrane transport [GO:1902600]	proton channel activity [GO:0015252]	plasma membrane [GO:0005886]	GO:0005886; GO:0015252; GO:1902600
GN009844	GN009844.1	Q9W6I0	34.2	152	349	200	1.27e-22	97.1	UQCC1_XENLA	Ubiquinol-cytochrome-c reductase complex assembly factor 1 (Basic FGF-repressed Zic-binding protein homolog) (Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog) (Zic3-binding protein)	Xenopus laevis (African clawed frog)	mitochondrial respiratory chain complex III assembly [GO:0034551]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0034551
GN009846	GN009846.1	Q8BKZ9	44.9	459	475	501	2.18e-112	343	ODPX_MOUSE	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X)	Mus musculus (Mouse)	pyruvate decarboxylation to acetyl-CoA [GO:0006086]	dihydrolipoyllysine-residue acetyltransferase activity [GO:0004742]; molecular adaptor activity [GO:0060090]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; pyruvate dehydrogenase complex [GO:0045254]	GO:0004742; GO:0005654; GO:0005739; GO:0005759; GO:0005886; GO:0006086; GO:0045254; GO:0060090
GN009848	GN009848.1	A2RU67	24.4	476	744	622	4.60e-26	117	F234B_HUMAN	Protein FAM234B	Homo sapiens (Human)			membrane [GO:0016020]; microtubule organizing center [GO:0005815]; postsynaptic Golgi apparatus [GO:0150051]	GO:0005815; GO:0016020; GO:0150051
GN009852	GN009852.1	Q9VFC8	65.6	639	697	709	0.0	891	GYS_DROME	Glycogen [starch] synthase (EC 2.4.1.11) (Glycogen synthase)	Drosophila melanogaster (Fruit fly)	cellular response to starvation [GO:0009267]; cellular response to sucrose stimulus [GO:0071329]; glycogen biosynthetic process [GO:0005978]; glycogen biosynthetic process via UDP-glucose [GO:0160249]; response to sucrose [GO:0009744]	alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity [GO:0004373]	autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004373; GO:0005737; GO:0005776; GO:0005829; GO:0005978; GO:0009267; GO:0009744; GO:0071329; GO:0160249
GN009856	GN009856.1	Q9QZH7	75.7	111	431	276	2.05e-51	177	FXL20_RAT	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like)	Rattus norvegicus (Rat)	behavioral fear response [GO:0001662]; regulation of protein catabolic process at presynapse, modulating synaptic transmission [GO:0099575]; regulation of synaptic vesicle exocytosis [GO:2000300]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793]; SCF ubiquitin ligase complex [GO:0019005]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]	GO:0001662; GO:0005737; GO:0019005; GO:0031146; GO:0045202; GO:0098685; GO:0098793; GO:0098978; GO:0099575; GO:1990756; GO:2000300
GN009857	GN009857.1	E7F6H7	52.3	666	660	626	1.12e-220	632	DCI2A_DANRE	Dynein, cytoplasmic 1, intermediate chain 2a	Danio rerio (Zebrafish) (Brachydanio rerio)	mitotic spindle organization [GO:0007052]; transport along microtubule [GO:0010970]	dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007052; GO:0010970; GO:0045503; GO:0045504
GN009860	GN009860.1	Q28262	38.7	403	447	444	3.21e-85	271	PAFA_CANLF	Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase)	Canis lupus familiaris (Dog) (Canis familiaris)	phosphatidylcholine catabolic process [GO:0034638]; platelet activating factor catabolic process [GO:0062234]; platelet activating factor metabolic process [GO:0046469]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; A2-type glycerophospholipase activity [GO:0004623]	high-density lipoprotein particle [GO:0034364]; low-density lipoprotein particle [GO:0034362]	GO:0003847; GO:0004623; GO:0034362; GO:0034364; GO:0034638; GO:0046469; GO:0062234
GN009867	GN009867.1	A3RL54	47.9	1170	1462	1325	0.0	972	SL9C1_STRPU	Sperm-specific sodium:proton exchanger (Solute carrier family 9 member C1) (Voltage-gated Na(+)/H(+) exchanger)	Strongylocentrotus purpuratus (Purple sea urchin)	regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]	cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; monoatomic ion channel activity [GO:0005216]; protein homodimerization activity [GO:0042803]; sodium:proton antiporter activity [GO:0015385]	membrane [GO:0016020]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]	GO:0005216; GO:0015385; GO:0016020; GO:0030552; GO:0030553; GO:0036126; GO:0042803; GO:0051453; GO:0061827; GO:0098719
GN009868	GN009868.1	Q2HJ55	47.2	405	419	469	1.77e-124	371	SAM50_BOVIN	Sorting and assembly machinery component 50 homolog	Bos taurus (Bovine)	cristae formation [GO:0042407]; protein insertion into mitochondrial outer membrane [GO:0045040]		cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]	GO:0001401; GO:0005737; GO:0005739; GO:0005741; GO:0042407; GO:0045040
GN009869	GN009869.1	A2BGM5	73.1	119	434	550	3.83e-52	186	FOXN4_DANRE	Forkhead box protein N4	Danio rerio (Zebrafish) (Brachydanio rerio)	amacrine cell differentiation [GO:0035881]; atrioventricular canal development [GO:0036302]; heart looping [GO:0001947]; heart valve development [GO:0003170]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of heart contraction [GO:0008016]; retina layer formation [GO:0010842]; ventral spinal cord interneuron fate commitment [GO:0060579]	chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000981; GO:0000987; GO:0001947; GO:0003170; GO:0003682; GO:0003700; GO:0005634; GO:0006355; GO:0008016; GO:0010842; GO:0035881; GO:0036302; GO:0043565; GO:0045893; GO:0045944; GO:0060579
GN009874	GN009874.1	P27641	40.8	725	2490	732	2.13e-139	458	XRCC5_MOUSE	DNA repair protein Ku80 (EC 4.2.99.18) (EC 5.6.2.4) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku autoantigen protein p86 homolog) (Ku80) (Nuclear factor IV) (X-ray repair cross-complementing protein 5)	Mus musculus (Mouse)	activation of innate immune response [GO:0002218]; cell population proliferation [GO:0008283]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to gamma radiation [GO:0071480]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to X-ray [GO:0071481]; DNA damage response [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; hematopoietic stem cell differentiation [GO:0060218]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of t-circle formation [GO:1904430]; positive regulation of neurogenesis [GO:0050769]; protein localization to chromosome, telomeric region [GO:0070198]; recombinational repair [GO:0000725]; regulation of smooth muscle cell proliferation [GO:0048660]; small-subunit processome assembly [GO:0034462]; telomere maintenance via telomerase [GO:0007004]	3'-5' DNA helicase activity [GO:0043138]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA end binding [GO:0045027]; double-stranded telomeric DNA binding [GO:0003691]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; telomeric repeat DNA binding [GO:0042162]; transcription cis-regulatory region binding [GO:0000976]; U3 snoRNA binding [GO:0034511]; ubiquitin protein ligase binding [GO:0031625]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; DNA-dependent protein kinase complex [GO:0070418]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; Ku70:Ku80 complex [GO:0043564]; nonhomologous end joining complex [GO:0070419]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; site of DNA damage [GO:0090734]; small-subunit processome [GO:0032040]	GO:0000725; GO:0000781; GO:0000976; GO:0002218; GO:0003684; GO:0003691; GO:0003723; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0005886; GO:0005958; GO:0006302; GO:0006303; GO:0006974; GO:0007004; GO:0008094; GO:0008283; GO:0016887; GO:0031625; GO:0032040; GO:0032991; GO:0032993; GO:0034462; GO:0034511; GO:0042162; GO:0043138; GO:0043564; GO:0044877; GO:0045027; GO:0045892; GO:0048660; GO:0050769; GO:0051575; GO:0060218; GO:0070198; GO:0070418; GO:0070419; GO:0071475; GO:0071480; GO:0071481; GO:0090734; GO:0140078; GO:1904430; GO:1990830; GO:1990904
GN009876	GN009876.1	Q9BDB7	39.8	264	274	447	1.29e-55	188	IF44L_MOUSE	Interferon-induced protein 44-like [Cleaved into: Minor histocompatibility antigen HA-28 (HLA-HA28) (IFL8)]	Mus musculus (Mouse)	cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; immune response [GO:0006955]		cytoplasm [GO:0005737]	GO:0005737; GO:0006955; GO:0051607; GO:0098586
GN009877	GN009877.1	Q53G44	40.0	295	467	452	2.81e-57	199	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN009878	GN009878.1	Q53G44	40.7	295	465	452	6.66e-59	203	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN009880	GN009880.1	P34416	32.3	486	468	335	4.12e-44	160	LASP1_CAEEL	LIM and SH3 domain protein F42H10.3	Caenorhabditis elegans		actin filament binding [GO:0051015]	cell junction [GO:0030054]; focal adhesion [GO:0005925]; striated muscle dense body [GO:0055120]	GO:0005925; GO:0030054; GO:0051015; GO:0055120
GN009881	GN009881.1	Q9GNE2	92.1	140	140	140	1.64e-87	254	RL23_AEDAE	Large ribosomal subunit protein uL14 (60S ribosomal protein L23) (AeRpL17A) (L17A)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	translation [GO:0006412]	large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]	GO:0003735; GO:0006412; GO:0022625; GO:0070180
GN009882	GN009882.1	Q03206	41.8	189	189	191	3.44e-44	148	RAC1_CAEEL	Ras-related protein ced-10 (EC 3.6.5.2) (CErac1) (Cell death protein 10) (Cell-corpse engulfment protein ced-10) (Ras-related protein rac-1)	Caenorhabditis elegans	actin filament organization [GO:0007015]; axon extension involved in axon guidance [GO:0048846]; axon regeneration [GO:0031103]; body morphogenesis [GO:0010171]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; chemorepulsion of axon [GO:0061643]; distal tip cell migration [GO:0097628]; dorsal/ventral axon guidance [GO:0033563]; embryonic body morphogenesis [GO:0010172]; embryonic morphogenesis [GO:0048598]; engulfment of apoptotic cell [GO:0043652]; establishment of mitotic spindle orientation [GO:0000132]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; establishment or maintenance of cell polarity [GO:0007163]; gastrulation [GO:0007369]; left/right axis specification [GO:0070986]; motor neuron axon guidance [GO:0008045]; negative regulation of microtubule polymerization [GO:0031115]; nematode larval development [GO:0002119]; nematode male tail tip morphogenesis [GO:0045138]; netrin-activated signaling pathway [GO:0038007]; neuron migration [GO:0001764]; neuron projection morphogenesis [GO:0048812]; positive regulation of distal tip cell migration [GO:1903356]; positive regulation of engulfment of apoptotic cell [GO:1901076]; Rac protein signal transduction [GO:0016601]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of dorsal/ventral axon guidance [GO:1905815]; regulation of phagocytosis [GO:0050764]; regulation of synaptic transmission, GABAergic [GO:0032228]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	GO:0000132; GO:0001764; GO:0002119; GO:0003924; GO:0003925; GO:0005525; GO:0005829; GO:0005856; GO:0005886; GO:0007015; GO:0007163; GO:0007264; GO:0007369; GO:0008045; GO:0008360; GO:0009898; GO:0010171; GO:0010172; GO:0016020; GO:0016477; GO:0016601; GO:0030334; GO:0030950; GO:0031103; GO:0031115; GO:0031410; GO:0032228; GO:0033563; GO:0038007; GO:0043025; GO:0043652; GO:0045138; GO:0048598; GO:0048812; GO:0048846; GO:0050764; GO:0060326; GO:0061643; GO:0070986; GO:0097628; GO:1901076; GO:1903356; GO:1905815
GN009883	GN009883.1	P34147	45.4	608	591	598	9.70e-176	513	RACA_DICDI	Rho-related protein racA (EC 3.6.5.2)	Dictyostelium discoideum (Social amoeba)	actin filament organization [GO:0007015]; establishment or maintenance of cell polarity [GO:0007163]; mitotic cytokinesis [GO:0000281]; regulation of cell shape [GO:0008360]; response to bacterium [GO:0009617]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; protein kinase binding [GO:0019901]	cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]	GO:0000281; GO:0003925; GO:0005525; GO:0005856; GO:0007015; GO:0007163; GO:0007264; GO:0008360; GO:0009617; GO:0019901; GO:0031410
GN009884	GN009884.1	A1Z6E0	34.6	136	239	279	6.60e-16	78.2	GUS_DROME	Protein gustavus	Drosophila melanogaster (Fruit fly)	cuticle pattern formation [GO:0035017]; dorsal appendage formation [GO:0046843]; germ cell development [GO:0007281]; germ cell migration [GO:0008354]; intracellular protein localization [GO:0008104]; intracellular signal transduction [GO:0035556]; oocyte anterior/posterior axis specification [GO:0007314]; pole plasm assembly [GO:0007315]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; wing disc morphogenesis [GO:0007472]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	cell cortex [GO:0005938]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; elongin complex [GO:0070449]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; pole plasm [GO:0045495]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005634; GO:0005737; GO:0005938; GO:0007281; GO:0007314; GO:0007315; GO:0007472; GO:0008104; GO:0008354; GO:0019005; GO:0031466; GO:0035017; GO:0035556; GO:0043161; GO:0045495; GO:0045732; GO:0046843; GO:0048471; GO:0070449; GO:1990756
GN009885	GN009885.1	P34147	30.2	258	303	598	3.04e-33	131	RACA_DICDI	Rho-related protein racA (EC 3.6.5.2)	Dictyostelium discoideum (Social amoeba)	actin filament organization [GO:0007015]; establishment or maintenance of cell polarity [GO:0007163]; mitotic cytokinesis [GO:0000281]; regulation of cell shape [GO:0008360]; response to bacterium [GO:0009617]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; protein kinase binding [GO:0019901]	cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]	GO:0000281; GO:0003925; GO:0005525; GO:0005856; GO:0007015; GO:0007163; GO:0007264; GO:0008360; GO:0009617; GO:0019901; GO:0031410
GN009886	GN009886.1	Q3T0K9	57.9	57	154	168	4.73e-11	60.8	DAZP2_BOVIN	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2) (Proline-rich transcript in brain protein)	Bos taurus (Bovine)	protein destabilization [GO:0031648]; stress granule assembly [GO:0034063]	DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; p53 binding [GO:0002039]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase binding [GO:0120283]; receptor tyrosine kinase binding [GO:0030971]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0002039; GO:0003713; GO:0005634; GO:0005737; GO:0010494; GO:0016604; GO:0016607; GO:0030971; GO:0031435; GO:0031625; GO:0031648; GO:0032991; GO:0034063; GO:0042802; GO:0043539; GO:0050699; GO:0120283; GO:0140297
GN009888	GN009888.1	O75581	23.1	247	458	1613	1.70e-17	89.4	LRP6_HUMAN	Low-density lipoprotein receptor-related protein 6 (LRP-6)	Homo sapiens (Human)	canonical Wnt signaling pathway [GO:0060070]; cell-cell adhesion [GO:0098609]; cellular response to cholesterol [GO:0071397]; chemical synaptic transmission [GO:0007268]; dopaminergic neuron differentiation [GO:0071542]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to plasma membrane [GO:0072659]; response to peptide hormone [GO:0043434]; Wnt signaling pathway [GO:0016055]	coreceptor activity [GO:0015026]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; kinase inhibitor activity [GO:0019210]; low-density lipoprotein particle receptor activity [GO:0005041]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase inhibitor activity [GO:0030291]; signaling receptor binding [GO:0005102]; toxin transmembrane transporter activity [GO:0019534]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; cytoplasmic vesicle [GO:0031410]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]; Wnt signalosome [GO:1990909]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]	GO:0005041; GO:0005102; GO:0005109; GO:0005576; GO:0005783; GO:0005886; GO:0007204; GO:0007268; GO:0007399; GO:0009986; GO:0014029; GO:0014033; GO:0015026; GO:0016055; GO:0017147; GO:0019210; GO:0019534; GO:0030291; GO:0031410; GO:0031901; GO:0034392; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043434; GO:0045121; GO:0045202; GO:0045787; GO:0045893; GO:0045944; GO:0060070; GO:0071397; GO:0071542; GO:0072659; GO:0098609; GO:1904948; GO:1990851; GO:1990909
GN009891	GN009891.1	P17972	78.6	435	747	498	3.21e-247	697	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN009893	GN009893.1	Q96KP4	64.0	475	449	475	4.58e-228	636	CNDP2_HUMAN	Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) (N-lactoyl-amino acid synthase/hydrolase) (EC 3.4.-.-) (Peptidase A) (Threonyl dipeptidase)	Homo sapiens (Human)	glutathione metabolic process [GO:0006749]; nonribosomal peptide biosynthetic process [GO:0019184]; proteolysis [GO:0006508]	carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metallodipeptidase activity [GO:0070573]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	GO:0004180; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006749; GO:0016805; GO:0019184; GO:0070062; GO:0070573
GN009894	GN009894.1	A6H619	37.7	477	1891	1682	1.37e-49	198	PHRF1_MOUSE	PHD and RING finger domain-containing protein 1	Mus musculus (Mouse)	mRNA processing [GO:0006397]; transcription by RNA polymerase II [GO:0006366]	protein domain specific binding [GO:0019904]; RNA polymerase binding [GO:0070063]		GO:0006366; GO:0006397; GO:0019904; GO:0070063
GN009896	GN009896.1	Q2TBS4	36.9	187	195	192	3.22e-29	110	CMAP3_BOVIN	Ciliary microtubule-associated protein 3 (Protein pitchfork)	Bos taurus (Bovine)	positive regulation of kinase activity [GO:0033674]; regulation of cell projection organization [GO:0031344]	cytoskeletal protein binding [GO:0008092]	ciliary basal body [GO:0036064]; cytoplasmic vesicle [GO:0031410]; trans-Golgi network [GO:0005802]	GO:0005802; GO:0008092; GO:0031344; GO:0031410; GO:0033674; GO:0036064
GN009897	GN009897.1	P32780	51.1	568	577	548	1.01e-182	529	TF2H1_HUMAN	General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit)	Homo sapiens (Human)	DNA repair [GO:0006281]; hormone-mediated signaling pathway [GO:0009755]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]	nuclear thyroid hormone receptor binding [GO:0046966]	nucleoplasm [GO:0005654]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]	GO:0000079; GO:0000439; GO:0005654; GO:0005675; GO:0006281; GO:0006289; GO:0006360; GO:0006366; GO:0006367; GO:0009755; GO:0045893; GO:0046966
GN009898	GN009898.1	Q7Z0T3	51.0	98	544	125	2.82e-27	109	TEMPT_APLCA	Temptin	Aplysia californica (California sea hare)			extracellular region [GO:0005576]	GO:0005576
GN009900	GN009900.1	Q9JI12	31.7	457	552	582	5.01e-87	283	VGLU2_RAT	Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6)	Rattus norvegicus (Rat)	hippocampus development [GO:0021766]; hyaloid vascular plexus regression [GO:1990384]; L-glutamate import [GO:0051938]; L-glutamate transmembrane transport [GO:0015813]; neural retina development [GO:0003407]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter uptake [GO:0001504]; phosphate ion homeostasis [GO:0055062]; phosphate ion transport [GO:0006817]; regulation of synapse structure or activity [GO:0050803]; sodium-dependent phosphate transport [GO:0044341]; synaptic transmission, glutamatergic [GO:0035249]	chloride channel activity [GO:0005254]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamate uniporter activity [GO:0140788]; neurotransmitter transmembrane transporter activity [GO:0005326]; phosphate ion uniporter activity [GO:0140787]; potassium:proton antiporter activity [GO:0015386]; sodium:phosphate symporter activity [GO:0005436]	early endosome [GO:0005769]; excitatory synapse [GO:0060076]; neuron projection [GO:0043005]; pericellular basket [GO:1990030]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	GO:0001504; GO:0003407; GO:0005254; GO:0005313; GO:0005326; GO:0005436; GO:0005769; GO:0005886; GO:0006817; GO:0008021; GO:0015386; GO:0015813; GO:0021766; GO:0030672; GO:0035249; GO:0043005; GO:0044341; GO:0050803; GO:0051938; GO:0055062; GO:0060076; GO:0098700; GO:0098793; GO:0140787; GO:0140788; GO:1990030; GO:1990384
GN009902	GN009902.1	Q8R151	36.5	1659	2354	1909	6.36e-279	878	ZNFX1_MOUSE	NFX1-type zinc finger-containing protein 1 (ATP- dependent RNA translocase ZNFX1) (EC 3.6.4.-) (E3 ubiquitin-protein and -ssRNA ligase ZNFX1) (EC 2.3.2.27)	Mus musculus (Mouse)	activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	helicase activity [GO:0004386]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380]	GO:0002218; GO:0003723; GO:0004386; GO:0005741; GO:0005829; GO:0008270; GO:0010494; GO:0031048; GO:0031380; GO:0042742; GO:0045071; GO:0051607; GO:0061630; GO:0140311; GO:1900226
GN009905	GN009905.1	Q5SVZ6	26.1	253	236	1142	7.26e-14	73.9	ZMYM1_HUMAN	Zinc finger MYM-type protein 1	Homo sapiens (Human)		protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0005634; GO:0008270; GO:0046983
GN009908	GN009908.1	P37233	34.9	338	414	396	4.77e-47	169	PPARD_XENLA	Peroxisome proliferator-activated receptor delta (PPAR-delta) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta)	Xenopus laevis (African clawed frog)	cell differentiation [GO:0030154]; energy homeostasis [GO:0097009]; fatty acid metabolic process [GO:0006631]; hormone-mediated signaling pathway [GO:0009755]; intracellular receptor signaling pathway [GO:0030522]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of inflammatory response [GO:0050728]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000978; GO:0001227; GO:0004879; GO:0005634; GO:0006631; GO:0008270; GO:0009755; GO:0010887; GO:0014842; GO:0030154; GO:0030522; GO:0045923; GO:0045944; GO:0050728; GO:0090575; GO:0097009
GN009910	GN009910.1	Q64337	34.2	225	234	442	2.46e-30	119	SQSTM_MOUSE	Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)	Mus musculus (Mouse)	aggrephagy [GO:0035973]; autophagy [GO:0006914]; brown fat cell proliferation [GO:0070342]; cellular response to stress [GO:0033554]; endosome organization [GO:0007032]; energy homeostasis [GO:0097009]; macroautophagy [GO:0016236]; membraneless organelle assembly [GO:0140694]; mitophagy [GO:0000423]; negative regulation of ferroptosis [GO:0110076]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pexophagy [GO:0000425]; positive regulation of autophagy [GO:0010508]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; protein K63-linked ubiquitination [GO:0070534]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein phosphorylation [GO:0006468]; protein targeting to vacuole involved in autophagy [GO:0071211]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of protein complex stability [GO:0061635]; response to ischemia [GO:0002931]; response to mitochondrial depolarisation [GO:0098780]; temperature homeostasis [GO:0001659]; toll-like receptor 4 signaling pathway [GO:0034142]; ubiquitin-dependent protein catabolic process [GO:0006511]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; molecular condensate scaffold activity [GO:0140693]; molecular sequestering activity [GO:0140313]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor activity [GO:0038023]; transcription coregulator activity [GO:0003712]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-modified protein reader activity [GO:0140036]; zinc ion binding [GO:0008270]	aggresome [GO:0016235]; amphisome [GO:0044753]; autolysosome [GO:0044754]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; inclusion body [GO:0016234]; intracellular membraneless organelle [GO:0043232]; late endosome [GO:0005770]; Lewy body [GO:0097413]; lysosome [GO:0005764]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; P-body [GO:0000932]; phagophore assembly site [GO:0000407]; PML body [GO:0016605]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]; synapse [GO:0045202]	GO:0000122; GO:0000407; GO:0000423; GO:0000425; GO:0000932; GO:0001659; GO:0001934; GO:0002931; GO:0003712; GO:0005080; GO:0005634; GO:0005737; GO:0005739; GO:0005764; GO:0005770; GO:0005776; GO:0005783; GO:0005829; GO:0006468; GO:0006511; GO:0006606; GO:0006914; GO:0007032; GO:0008270; GO:0010508; GO:0016234; GO:0016235; GO:0016236; GO:0016605; GO:0019899; GO:0019901; GO:0030017; GO:0030163; GO:0030674; GO:0031397; GO:0031625; GO:0033554; GO:0034142; GO:0034144; GO:0035255; GO:0035591; GO:0035973; GO:0036464; GO:0038023; GO:0042169; GO:0042802; GO:0043122; GO:0043130; GO:0043232; GO:0044753; GO:0044754; GO:0044877; GO:0045202; GO:0061635; GO:0070342; GO:0070530; GO:0070534; GO:0071211; GO:0097009; GO:0097225; GO:0097413; GO:0098780; GO:0098978; GO:0110076; GO:0140036; GO:0140311; GO:0140313; GO:0140693; GO:0140694; GO:1900273; GO:1903078; GO:1905719
GN009917	GN009917.1	P07314	61.7	47	68	568	3.56e-11	59.7	GGT1_RAT	Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]	Rattus norvegicus (Rat)	amino acid metabolic process [GO:0006520]; cellular response to oxidative stress [GO:0034599]; fatty acid metabolic process [GO:0006631]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; hepatoblast differentiation [GO:0061017]; hepatocyte differentiation [GO:0070365]; L-cysteine biosynthetic process [GO:0019344]; leukotriene D4 biosynthetic process [GO:1901750]; leukotriene metabolic process [GO:0006691]; liver regeneration [GO:0097421]; peptide modification [GO:0031179]; proteolysis [GO:0006508]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; response to alcohol [GO:0097305]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; spermatogenesis [GO:0007283]; zymogen activation [GO:0031638]	aminoacyltransferase activity [GO:0016755]; glutathione gamma-glutamate hydrolase [GO:0036374]; leukotriene-C(4) hydrolase activity [GO:0002951]; peptidyltransferase activity [GO:0000048]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GO:0000048; GO:0002682; GO:0002951; GO:0005576; GO:0005886; GO:0006508; GO:0006520; GO:0006536; GO:0006631; GO:0006691; GO:0006750; GO:0006751; GO:0007283; GO:0016755; GO:0019344; GO:0031179; GO:0031638; GO:0031982; GO:0032355; GO:0032496; GO:0034599; GO:0034612; GO:0036374; GO:0050727; GO:0061017; GO:0070365; GO:0097305; GO:0097421; GO:1901750
GN009919	GN009919.1	Q13003	33.5	508	788	919	2.15e-78	274	GRIK3_HUMAN	Glutamate receptor ionotropic, kainate 3 (GluK3) (Excitatory amino acid receptor 5) (EAA5) (Glutamate receptor 7) (GluR-7) (GluR7)	Homo sapiens (Human)	G protein-coupled glutamate receptor signaling pathway [GO:0007216]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; regulation of membrane potential [GO:0042391]; synaptic transmission, glutamatergic [GO:0035249]	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; glutamate receptor activity [GO:0008066]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	axon [GO:0030424]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; kainate selective glutamate receptor complex [GO:0032983]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; terminal bouton [GO:0043195]	GO:0001640; GO:0004970; GO:0005886; GO:0007215; GO:0007216; GO:0008066; GO:0015277; GO:0022849; GO:0030424; GO:0030425; GO:0032839; GO:0032983; GO:0035249; GO:0042391; GO:0042734; GO:0043195; GO:0043204; GO:0045211; GO:0050804; GO:0051967; GO:0098839; GO:0098978; GO:0099507; GO:1904315
GN009920	GN009920.1	Q13002	33.0	342	348	908	9.47e-48	176	GRIK2_HUMAN	Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)	Homo sapiens (Human)	chemical synaptic transmission [GO:0007268]; detection of cold stimulus involved in thermoception [GO:0120169]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; modulation of excitatory postsynaptic potential [GO:0098815]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuron apoptotic process [GO:0051402]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of synaptic transmission [GO:0050806]; receptor clustering [GO:0043113]; regulation of JNK cascade [GO:0046328]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]	extracellularly glutamate-gated ion channel activity [GO:0005234]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; identical protein binding [GO:0042802]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; PDZ domain binding [GO:0030165]; scaffold protein binding [GO:0097110]; SNARE binding [GO:0000149]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625]	dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; mossy fiber rosette [GO:0097471]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]; terminal bouton [GO:0043195]	GO:0000149; GO:0004970; GO:0005234; GO:0005886; GO:0007215; GO:0007268; GO:0015277; GO:0022849; GO:0030165; GO:0031624; GO:0031625; GO:0032839; GO:0032983; GO:0035249; GO:0042734; GO:0042802; GO:0043113; GO:0043195; GO:0043204; GO:0043525; GO:0046328; GO:0048172; GO:0050804; GO:0050806; GO:0051402; GO:0051967; GO:0097110; GO:0097471; GO:0098686; GO:0098815; GO:0098839; GO:0098978; GO:0099507; GO:0120169; GO:1904315
GN009921	GN009921.1	P53621	77.4	1056	1073	1224	0.0	1599	COPA_HUMAN	Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]	Homo sapiens (Human)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; pancreatic juice secretion [GO:0030157]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	mRNA binding [GO:0003729]; structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; growth cone [GO:0030426]; membrane [GO:0016020]; transport vesicle [GO:0030133]	GO:0000139; GO:0003729; GO:0005198; GO:0005576; GO:0005737; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0006890; GO:0006891; GO:0016020; GO:0030126; GO:0030133; GO:0030157; GO:0030426; GO:0070062
GN009922	GN009922.1	A4D9B0	29.5	438	398	453	3.71e-49	175	EGT2A_ASPFU	Hercynylcysteine sulfoxide lyase (EC 4.4.1.-)	Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)	selenoneine biosynthetic process [GO:1903257]	hercynylcysteine sulfoxide lyase activity (ergothioneine-forming) [GO:1990411]		GO:1903257; GO:1990411
GN009923	GN009923.1	A4D9B0	29.1	440	398	453	1.45e-47	171	EGT2A_ASPFU	Hercynylcysteine sulfoxide lyase (EC 4.4.1.-)	Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)	selenoneine biosynthetic process [GO:1903257]	hercynylcysteine sulfoxide lyase activity (ergothioneine-forming) [GO:1990411]		GO:1903257; GO:1990411
GN009926	GN009926.1	O35015	42.6	425	478	510	6.26e-109	335	YNGK_BACSU	Glycosyl hydrolase YngK (EC 3.2.1.-)	Bacillus subtilis (strain 168)				
GN009932	GN009932.1	G5E8P0	28.7	1770	1531	1769	1.37e-164	545	GCP6_MOUSE	Gamma-tubulin complex component 6 (GCP-6)	Mus musculus (Mouse)	meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225]	gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]	centrosome [GO:0005813]; gamma-tubulin ring complex [GO:0000931]; spindle pole [GO:0000922]	GO:0000278; GO:0000922; GO:0000931; GO:0005813; GO:0007020; GO:0008017; GO:0043015; GO:0051225; GO:0051321
GN009935	GN009935.1	Q28F07	73.6	345	359	351	1.06e-182	512	ANM1_XENTR	Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 2) (Histone-arginine N-methyltransferase PRMT1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cardiac muscle tissue development [GO:0048738]; cellular response to methionine [GO:0061431]; metamorphosis [GO:0007552]; negative regulation of megakaryocyte differentiation [GO:0045653]; neurogenesis [GO:0022008]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of TORC1 signaling [GO:1904263]; regulation of megakaryocyte differentiation [GO:0045652]; RNA splicing [GO:0008380]	GATOR1 complex binding [GO:0106080]; histone H4R3 methyltransferase activity [GO:0044020]; histone methyltransferase activity [GO:0042054]; identical protein binding [GO:0042802]; N-methyltransferase activity [GO:0008170]; protein methyltransferase activity [GO:0008276]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; S-adenosyl-L-methionine binding [GO:1904047]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007552; GO:0008170; GO:0008276; GO:0008380; GO:0016274; GO:0022008; GO:0035241; GO:0035242; GO:0042054; GO:0042802; GO:0044020; GO:0045652; GO:0045653; GO:0045893; GO:0048738; GO:0061431; GO:0106080; GO:1904047; GO:1904263; GO:1905168
GN009936	GN009936.1	A2XYY8	40.4	339	414	379	2.99e-81	257	ANM61_ORYSI	Probable protein arginine N-methyltransferase 6.1 (EC 2.1.1.-)	Oryza sativa subsp. indica (Rice)		histone methyltransferase activity [GO:0042054]; protein-arginine N-methyltransferase activity [GO:0016274]		GO:0016274; GO:0042054
GN009938	GN009938.1	Q7ZU90	51.3	575	942	1026	1.43e-169	524	CHD1L_DANRE	ATP-dependent chromatin remodeler CHD1l (EC 3.6.4.-) (Chromo domain-containing protein 1-like)	Danio rerio (Zebrafish) (Brachydanio rerio)	brain development [GO:0007420]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA helicase activity [GO:0003678]; histone reader activity [GO:0140566]; nucleosome binding [GO:0031491]; nucleotide binding [GO:0000166]; poly-ADP-D-ribose modification-dependent protein binding [GO:0160004]	chromosome [GO:0005694]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000166; GO:0003678; GO:0005524; GO:0005634; GO:0005694; GO:0006281; GO:0006338; GO:0006974; GO:0007420; GO:0016887; GO:0031491; GO:0035861; GO:0140566; GO:0140658; GO:0160004
GN009939	GN009939.1	Q96JG6	53.9	980	955	964	0.0	956	VPS50_HUMAN	Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50)	Homo sapiens (Human)	endocytic recycling [GO:0032456]	SNARE binding [GO:0000149]	EARP complex [GO:1990745]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]	GO:0000149; GO:0016020; GO:0032456; GO:0048471; GO:0055037; GO:0070062; GO:1990745
GN009940	GN009940.1	Q8NCJ5	55.7	433	430	442	3.51e-154	446	SPRY3_HUMAN	SPRY domain-containing protein 3	Homo sapiens (Human)		protein-macromolecule adaptor activity [GO:0030674]		GO:0030674
GN009943	GN009943.1	Q400C8	32.5	249	361	359	2.36e-35	135	AMZ2_MOUSE	Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2)	Mus musculus (Mouse)	proteolysis [GO:0006508]	metallopeptidase activity [GO:0008237]	nucleoplasm [GO:0005654]	GO:0005654; GO:0006508; GO:0008237
GN009944	GN009944.1	Q6ZMV9	48.8	346	381	814	1.54e-93	300	KIF6_HUMAN	Kinesin-like protein KIF6	Homo sapiens (Human)	microtubule-based movement [GO:0007018]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	kinesin complex [GO:0005871]	GO:0003777; GO:0005524; GO:0005871; GO:0007018; GO:0008017
GN009945	GN009945.1	P56701	71.5	842	880	908	0.0	1168	PSMD2_BOVIN	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Tumor necrosis factor type 1 receptor-associated protein 2)	Bos taurus (Bovine)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176]	enzyme regulator activity [GO:0030234]	cytosol [GO:0005829]; proteasome accessory complex [GO:0022624]; proteasome regulatory particle [GO:0005838]; proteasome storage granule [GO:0034515]	GO:0005829; GO:0005838; GO:0022624; GO:0030234; GO:0034515; GO:0042176; GO:0043161
GN009946	GN009946.1	Q99PW8	43.0	1052	1098	1038	2.19e-236	703	KIF17_MOUSE	Kinesin-like protein KIF17 (MmKIF17)	Mus musculus (Mouse)	anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]; intraciliary transport [GO:0042073]; microtubule-based process [GO:0007017]; protein-containing complex localization [GO:0031503]; vesicle-mediated transport [GO:0016192]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; neuron projection [GO:0043005]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; postsynapse [GO:0098794]	GO:0001750; GO:0001917; GO:0003777; GO:0005524; GO:0005815; GO:0005829; GO:0005871; GO:0005929; GO:0005930; GO:0007017; GO:0008017; GO:0008574; GO:0015630; GO:0016192; GO:0031503; GO:0032391; GO:0032839; GO:0036064; GO:0042073; GO:0043005; GO:0098794; GO:0098971; GO:1990075
GN009947	GN009947.1	H2A0M7	43.5	550	725	793	4.71e-126	397	PLSP_PINMG	Peroxidase-like protein	Margaritifera margaritifera (Freshwater pearl mussel)	response to oxidative stress [GO:0006979]	heme binding [GO:0020037]; peroxidase activity [GO:0004601]	extracellular region [GO:0005576]	GO:0004601; GO:0005576; GO:0006979; GO:0020037
GN009948	GN009948.1	O95985	70.5	352	350	862	3.02e-171	501	TOP3B_HUMAN	DNA topoisomerase 3-beta-1 (EC 5.6.2.1) (DNA topoisomerase III beta-1)	Homo sapiens (Human)	DNA topological change [GO:0006265]	DNA binding [GO:0003677]; DNA topoisomerase activity [GO:0003916]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; RNA binding [GO:0003723]; RNA topoisomerase activity [GO:0140226]	condensed chromosome [GO:0000793]; DNA topoisomerase III-beta-TDRD3 complex [GO:0140225]; nucleus [GO:0005634]	GO:0000793; GO:0003677; GO:0003723; GO:0003916; GO:0003917; GO:0005634; GO:0006265; GO:0140225; GO:0140226
GN009950	GN009950.1	O95045	53.4	294	304	317	1.40e-105	313	UPP2_HUMAN	Uridine phosphorylase 2 (UPase 2) (UrdPase 2) (EC 2.4.2.3)	Homo sapiens (Human)	CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dTMP catabolic process [GO:0046074]; dUMP catabolic process [GO:0046079]; nucleoside metabolic process [GO:0009116]; UMP catabolic process [GO:0046050]; UMP salvage [GO:0044206]; uridine catabolic process [GO:0006218]; uridine metabolic process [GO:0046108]; xenobiotic catabolic process [GO:0042178]	deoxyuridine phosphorylase activity [GO:0047847]; identical protein binding [GO:0042802]; pyrimidine-nucleoside phosphorylase activity [GO:0016154]; thymidine phosphorylase activity [GO:0009032]; uridine phosphorylase activity [GO:0004850]	cytosol [GO:0005829]; type III intermediate filament [GO:0045098]	GO:0004850; GO:0005829; GO:0006218; GO:0006248; GO:0006249; GO:0009032; GO:0009116; GO:0016154; GO:0042178; GO:0042802; GO:0044206; GO:0045098; GO:0046050; GO:0046074; GO:0046079; GO:0046108; GO:0047847
GN009951	GN009951.1	Q7TQK0	63.9	219	829	723	3.06e-80	276	CCNT2_MOUSE	Cyclin-T2 (CycT2)	Mus musculus (Mouse)	early viral transcription [GO:0019085]; late viral transcription [GO:0019086]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of muscle cell differentiation [GO:0051147]; skeletal muscle tissue development [GO:0007519]	7SK snRNA binding [GO:0097322]; chromatin binding [GO:0003682]; cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]; protein kinase binding [GO:0019901]; RNA polymerase binding [GO:0070063]; transcription coactivator binding [GO:0001223]	cyclin/CDK positive transcription elongation factor complex [GO:0008024]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0001223; GO:0003682; GO:0005634; GO:0007519; GO:0008024; GO:0019085; GO:0019086; GO:0019901; GO:0032786; GO:0032968; GO:0045944; GO:0048471; GO:0051147; GO:0061575; GO:0070063; GO:0097322
GN009952	GN009952.1	Q9H9L4	45.7	370	535	492	7.18e-81	264	KANL2_HUMAN	KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog)	Homo sapiens (Human)	positive regulation of DNA-templated transcription [GO:0045893]		cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; mitochondrion [GO:0005739]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000123; GO:0005634; GO:0005654; GO:0005739; GO:0005829; GO:0005886; GO:0044545; GO:0045893
GN009953	GN009953.1	Q7T330	72.5	142	142	374	4.23e-69	215	SPOP_DANRE	Speckle-type POZ protein (HIB homolog 1) (SPOP1)	Danio rerio (Zebrafish) (Brachydanio rerio)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of proteolysis [GO:0030162]	ubiquitin protein ligase binding [GO:0031625]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0016567; GO:0016607; GO:0030162; GO:0031463; GO:0031625; GO:0043161
GN009954	GN009954.1	Q9VFP2	88.0	209	219	829	1.27e-125	377	RDX_DROME	Protein roadkill (Hh-induced MATH and BTB domain-containing protein)	Drosophila melanogaster (Fruit fly)	compound eye morphogenesis [GO:0001745]; eye development [GO:0001654]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; regulation of proteolysis [GO:0030162]; segment polarity determination [GO:0007367]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001654; GO:0001745; GO:0005634; GO:0005654; GO:0005737; GO:0007367; GO:0016567; GO:0030162; GO:0031463; GO:0031625; GO:0031648; GO:0042308; GO:0042802; GO:0042803; GO:0043065; GO:0043161; GO:0045732; GO:0045879; GO:0046330; GO:0070936; GO:1990756
GN009956	GN009956.1	Q8AVX5	49.0	361	354	353	1.51e-98	298	XRP2_XENLA	Protein XRP2	Xenopus laevis (African clawed frog)	post-Golgi vesicle-mediated transport [GO:0006892]	GTPase activator activity [GO:0005096]	ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; periciliary membrane compartment [GO:1990075]; plasma membrane [GO:0005886]	GO:0005096; GO:0005737; GO:0005886; GO:0005929; GO:0006892; GO:0012505; GO:0036064; GO:1990075
GN009958	GN009958.1	Q7Z4S6	38.6	1444	1343	1674	5.60e-216	677	KI21A_HUMAN	Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62)	Homo sapiens (Human)	anterograde axonal transport [GO:0008089]; cortical microtubule organization [GO:0043622]; establishment or maintenance of cell polarity [GO:0007163]; regulation of axon guidance [GO:1902667]; regulation of microtubule depolymerization [GO:0031114]; regulation of microtubule polymerization [GO:0031113]	ankyrin repeat binding [GO:0071532]; ATP binding [GO:0005524]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]	axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; dendrite [GO:0030425]; kinesin complex [GO:0005871]; microtubule associated complex [GO:0005875]; presynapse [GO:0098793]	GO:0005524; GO:0005871; GO:0005875; GO:0005938; GO:0007163; GO:0008017; GO:0008089; GO:0008574; GO:0030425; GO:0031113; GO:0031114; GO:0043622; GO:0044295; GO:0071532; GO:0098793; GO:1902667; GO:1904115
GN009961	GN009961.1	Q80YV2	32.9	216	828	501	3.34e-25	114	ZC3C1_MOUSE	Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (mNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase)	Mus musculus (Mouse)		protein kinase binding [GO:0019901]; zinc ion binding [GO:0008270]	nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005635; GO:0005654; GO:0008270; GO:0019901; GO:0031965; GO:0044615
GN009962	GN009962.1	Q5ZEQ8	28.7	331	456	427	1.29e-33	134	FJX1_XIPMA	Four-jointed box protein 1 (Four-jointed protein homolog)	Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)	cell-cell signaling [GO:0007267]		extracellular region [GO:0005576]	GO:0005576; GO:0007267
GN009963	GN009963.1	Q9ES30	31.3	112	243	246	6.67e-09	58.2	C1QT3_MOUSE	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	Mus musculus (Mouse)	fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; intracellular triglyceride homeostasis [GO:0035356]; maintenance of synapse structure [GO:0099558]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular region [GO:0005576]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001819; GO:0005576; GO:0010629; GO:0032715; GO:0032991; GO:0035356; GO:0042593; GO:0042802; GO:0043083; GO:0045202; GO:0045444; GO:0045721; GO:0050728; GO:0051897; GO:0070165; GO:0070374; GO:0071638; GO:0099550; GO:0099558; GO:1901223
GN009964	GN009964.1	Q9ES30	32.7	110	125	246	3.04e-11	61.6	C1QT3_MOUSE	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	Mus musculus (Mouse)	fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; intracellular triglyceride homeostasis [GO:0035356]; maintenance of synapse structure [GO:0099558]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular region [GO:0005576]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001819; GO:0005576; GO:0010629; GO:0032715; GO:0032991; GO:0035356; GO:0042593; GO:0042802; GO:0043083; GO:0045202; GO:0045444; GO:0045721; GO:0050728; GO:0051897; GO:0070165; GO:0070374; GO:0071638; GO:0099550; GO:0099558; GO:1901223
GN009965	GN009965.1	Q3SZI6	38.7	626	631	631	9.54e-132	403	RPN2_BOVIN	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (Ribophorin II) (RPN-II) (Ribophorin-2)	Bos taurus (Bovine)	protein N-linked glycosylation [GO:0006487]		endoplasmic reticulum [GO:0005783]; oligosaccharyltransferase complex [GO:0008250]	GO:0005783; GO:0006487; GO:0008250
GN009966	GN009966.1	Q9VRV7	75.6	119	123	121	3.26e-65	196	SF3B6_DROME	Splicing factor 3B subunit 6 (Pre-mRNA branch site p14-like protein)	Drosophila melanogaster (Fruit fly)	mRNA splicing, via spliceosome [GO:0000398]	mRNA binding [GO:0003729]	catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]	GO:0000398; GO:0003729; GO:0005634; GO:0071011; GO:0071013
GN009968	GN009968.1	F1MBP6	35.2	256	300	587	4.41e-42	155	KLHL3_BOVIN	Kelch-like protein 3	Bos taurus (Bovine)	distal tubule morphogenesis [GO:0072156]; monoatomic ion homeostasis [GO:0050801]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; renal sodium ion absorption [GO:0070294]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0005856; GO:0006511; GO:0016567; GO:0031463; GO:0043161; GO:0050801; GO:0070294; GO:0070936; GO:0072156; GO:1990756
GN009969	GN009969.1	Q3ZAV0	25.7	495	913	542	9.94e-13	75.5	CCD60_RAT	Coiled-coil domain-containing protein 60	Rattus norvegicus (Rat)				
GN009971	GN009971.1	Q6DF57	45.2	259	260	261	9.51e-66	208	GPT11_XENTR	G patch domain-containing protein 11 (Coiled-coil domain-containing protein 75)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		nucleic acid binding [GO:0003676]	kinetochore [GO:0000776]	GO:0000776; GO:0003676
GN009974	GN009974.1	Q91ZW9	41.4	133	214	178	1.24e-23	95.9	C209C_MOUSE	CD209 antigen-like protein C (DC-SIGN-related protein 2) (DC-SIGNR2) (CD antigen CD209)	Mus musculus (Mouse)	B cell adhesion [GO:0097323]; dendritic cell migration [GO:0036336]; immature T cell proliferation [GO:0033079]; immune response [GO:0006955]; leukocyte cell-cell adhesion [GO:0007159]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of viral life cycle [GO:1903902]; symbiont entry into host cell [GO:0046718]	cell adhesion receptor activity [GO:0004895]; D-mannose binding [GO:0005537]; pattern recognition receptor activity [GO:0038187]; virus receptor activity [GO:0001618]	external side of plasma membrane [GO:0009897]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0001618; GO:0004895; GO:0005537; GO:0005886; GO:0006955; GO:0007159; GO:0009897; GO:0033079; GO:0036336; GO:0038187; GO:0042102; GO:0045121; GO:0046718; GO:0097323; GO:1903902
GN009978	GN009978.1	Q23551	43.9	98	116	7158	8.34e-20	86.7	UNC22_CAEEL	Twitchin (EC 2.7.11.1) (Uncoordinated protein 22)	Caenorhabditis elegans	adult locomotory behavior [GO:0008344]; negative regulation of cell division [GO:0051782]; positive regulation of locomotion [GO:0040017]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of striated muscle contraction [GO:0045989]; sarcomere organization [GO:0045214]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; structural constituent of muscle [GO:0008307]	A band [GO:0031672]; M band [GO:0031430]	GO:0004674; GO:0005524; GO:0008307; GO:0008344; GO:0031430; GO:0031672; GO:0040017; GO:0045214; GO:0045989; GO:0051782; GO:0060298; GO:0106310
GN009979	GN009979.1	O89110	34.9	229	480	480	5.63e-37	145	CASP8_MOUSE	Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]	Mus musculus (Mouse)	angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cardiac muscle tissue development [GO:0048738]; cellular response to mechanical stimulus [GO:0071260]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; heart development [GO:0007507]; hepatocyte apoptotic process [GO:0097284]; macrophage differentiation [GO:0030225]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of necroptotic process [GO:0060546]; neural tube formation [GO:0001841]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of proteolysis [GO:0045862]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of cytokine production [GO:0001817]; regulation of innate immune response [GO:0045088]; regulation of thymocyte apoptotic process [GO:0070243]; response to ethanol [GO:0045471]; response to tumor necrosis factor [GO:0034612]; self proteolysis [GO:0097264]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]	caspase complex [GO:0008303]; CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; lamellipodium [GO:0030027]; mitochondrion [GO:0005739]; Noc1p-Noc2p complex [GO:0030690]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ripoptosome [GO:0097342]	GO:0001525; GO:0001817; GO:0001841; GO:0004175; GO:0004197; GO:0005123; GO:0005164; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006508; GO:0006915; GO:0007507; GO:0008233; GO:0008303; GO:0008625; GO:0008656; GO:0016485; GO:0030027; GO:0030163; GO:0030225; GO:0030335; GO:0030690; GO:0031264; GO:0031265; GO:0031625; GO:0032731; GO:0032991; GO:0034612; GO:0035877; GO:0036462; GO:0042802; GO:0043065; GO:0043123; GO:0043124; GO:0043525; GO:0044297; GO:0044877; GO:0045088; GO:0045471; GO:0045651; GO:0045862; GO:0048738; GO:0051604; GO:0060546; GO:0070243; GO:0070269; GO:0071260; GO:0097110; GO:0097190; GO:0097191; GO:0097194; GO:0097264; GO:0097284; GO:0097342; GO:0140639; GO:1900119; GO:2001233; GO:2001238
GN009995	GN009995.1	Q56H79	24.8	133	441	371	2.44e-09	62.4	NPSR1_MACMU	Neuropeptide S receptor (G protein-coupled receptor 154)	Macaca mulatta (Rhesus macaque)	neuropeptide signaling pathway [GO:0007218]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]	neuropeptide receptor activity [GO:0008188]; vasopressin receptor activity [GO:0005000]	plasma membrane [GO:0005886]	GO:0005000; GO:0005886; GO:0007218; GO:0008188; GO:0051281; GO:0070374; GO:0141163
GN009996	GN009996.1	P50219	60.6	132	338	401	1.50e-38	144	MNX1_HUMAN	Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9)	Homo sapiens (Human)	central nervous system development [GO:0007417]; endocrine pancreas development [GO:0031018]; neuron projection morphogenesis [GO:0048812]; spinal cord motor neuron cell fate specification [GO:0021520]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000981; GO:0001227; GO:0005634; GO:0007417; GO:0021520; GO:0031018; GO:0048812; GO:1990837
GN009997	GN009997.1	Q8JHJ2	59.5	524	571	593	7.58e-205	587	DDX55_DANRE	ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55)	Danio rerio (Zebrafish) (Brachydanio rerio)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0003723; GO:0003724; GO:0005524; GO:0005654; GO:0005730; GO:0016887
GN010001	GN010001.1	O14095	43.2	183	203	279	1.34e-38	137	PLP1_SCHPO	Thioredoxin domain-containing protein plp1 (Phosducin-like protein 1)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	protein folding [GO:0006457]		cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0006457
GN010002	GN010002.1	O95373	59.4	993	991	1038	0.0	1155	IPO7_HUMAN	Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7)	Homo sapiens (Human)	negative regulation of cell cycle [GO:0045786]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of protein localization to nucleus [GO:1900182]; protein import into nucleus [GO:0006606]	GTPase regulator activity [GO:0030695]; histone binding [GO:0042393]; nuclear import signal receptor activity [GO:0061608]; SMAD binding [GO:0046332]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005635; GO:0005643; GO:0005654; GO:0005737; GO:0005829; GO:0006606; GO:0016020; GO:0030695; GO:0031267; GO:0042393; GO:0045668; GO:0045786; GO:0046332; GO:0061608; GO:1900182; GO:1901331
GN010005	GN010005.1	Q9FT72	31.6	171	191	713	6.44e-13	69.7	RQL3_ARATH	ATP-dependent DNA helicase Q-like 3 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ3) (RecQ-like protein 3) (AtRecQ3) (AtRecQl3)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004386; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006310; GO:0009378; GO:0016887; GO:0043138; GO:1990814
GN010006	GN010006.1	D2YVH7	38.0	92	97	158	3.63e-12	61.6	LECM_OXYSU	C-type lectin mannose-binding isoform (CTL) (Venom C-type lectin mannose-binding isoform 1)	Oxyuranus scutellatus (Coastal taipan)			extracellular region [GO:0005576]	GO:0005576
GN010007	GN010007.1	P86854	36.3	124	211	156	3.93e-22	91.3	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN010008	GN010008.1	O75096	58.6	915	1110	1905	7.32e-189	602	LRP4_HUMAN	Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)	Homo sapiens (Human)	amyloid-beta clearance by cellular catabolic process [GO:0150094]; dendrite morphogenesis [GO:0048813]; enzyme-linked receptor protein signaling pathway [GO:0007167]; generation of neurons [GO:0048699]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; regulation of postsynapse assembly [GO:0150052]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic assembly at neuromuscular junction [GO:0051124]	apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; coreceptor activity [GO:0015026]; protein homodimerization activity [GO:0042803]; receptor tyrosine kinase binding [GO:0030971]; scaffold protein binding [GO:0097110]; virus receptor activity [GO:0001618]	cell surface [GO:0009986]; dendrite [GO:0030425]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060]	GO:0001618; GO:0001822; GO:0005509; GO:0005886; GO:0007167; GO:0009986; GO:0014069; GO:0015026; GO:0030279; GO:0030425; GO:0030971; GO:0031594; GO:0034185; GO:0035022; GO:0042803; GO:0043025; GO:0044853; GO:0048699; GO:0048813; GO:0050771; GO:0050808; GO:0051124; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:0150052; GO:0150094; GO:1901631; GO:1904395
GN010009	GN010009.1	H2A0L6	34.2	784	1031	1135	1.38e-114	384	HEX_PINMG	Putative beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase)	Margaritifera margaritifera (Freshwater pearl mussel)	carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; glycosaminoglycan metabolic process [GO:0030203]	beta-N-acetylhexosaminidase activity [GO:0004563]; polysaccharide binding [GO:0030247]	extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0004563; GO:0005576; GO:0005975; GO:0006032; GO:0016020; GO:0030203; GO:0030247
GN010010	GN010010.1	Q3SZQ6	76.7	133	134	135	6.13e-69	206	RL32_BOVIN	Large ribosomal subunit protein eL32 (60S ribosomal protein L32)	Bos taurus (Bovine)	cytoplasmic translation [GO:0002181]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]; synapse [GO:0045202]	GO:0002181; GO:0003735; GO:0005737; GO:0022625; GO:0045202
GN010011	GN010011.1	Q3ZBT5	37.6	226	327	261	2.15e-31	121	STX7_BOVIN	Syntaxin-7	Bos taurus (Bovine)	intracellular protein transport [GO:0006886]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]	chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	azurophil granule [GO:0042582]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; immunological synapse [GO:0001772]; late endosome [GO:0005770]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; tertiary granule [GO:0070820]	GO:0000149; GO:0001772; GO:0001916; GO:0005484; GO:0005770; GO:0006886; GO:0008021; GO:0019869; GO:0030139; GO:0031901; GO:0042582; GO:0048278; GO:0048471; GO:0055037; GO:0070820; GO:1902685; GO:1903076
GN010012	GN010012.1	P0C0T0	42.0	143	146	161	2.05e-27	102	LITAF_RAT	Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Estrogen-enhanced transcript protein 1) (Eet-1)	Rattus norvegicus (Rat)	cellular response to lipopolysaccharide [GO:0071222]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cytokine production [GO:0001817]; response to lipopolysaccharide [GO:0032496]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytoplasmic side of plasma membrane [GO:0009898]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000139; GO:0000978; GO:0001228; GO:0001817; GO:0005576; GO:0005634; GO:0005654; GO:0005737; GO:0005765; GO:0005794; GO:0005886; GO:0008270; GO:0009898; GO:0010008; GO:0016607; GO:0031901; GO:0031902; GO:0032496; GO:0042802; GO:0043123; GO:0045944; GO:0050699; GO:0071222; GO:0098559; GO:0098560; GO:0098574; GO:1901223
GN010013	GN010013.1	O73888	42.4	203	203	199	1.69e-47	157	HPGDS_CHICK	Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase)	Gallus gallus (Chicken)	glutathione metabolic process [GO:0006749]; prostaglandin metabolic process [GO:0006693]	calcium ion binding [GO:0005509]; glutathione transferase activity [GO:0004364]; magnesium ion binding [GO:0000287]; prostaglandin-D synthase activity [GO:0004667]	cytoplasm [GO:0005737]	GO:0000287; GO:0004364; GO:0004667; GO:0005509; GO:0005737; GO:0006693; GO:0006749
GN010014	GN010014.1	Q571C7	38.8	242	731	2467	9.48e-31	134	BDP1_MOUSE	Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator)	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of DNA-templated transcription [GO:0006355]; RNA polymerase III preinitiation complex assembly [GO:0070898]	TFIIIC-class transcription factor complex binding [GO:0001156]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIIB complex [GO:0000126]	GO:0000126; GO:0001156; GO:0005634; GO:0005654; GO:0006355; GO:0045945; GO:0070898
GN010016	GN010016.1	C0HKD8	56.7	439	448	439	9.89e-99	305	MFA1A_MOUSE	Microfibrillar-associated protein 1A (Spliceosome B complex protein MFAP1A)	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]		centrosome [GO:0005813]; extracellular matrix [GO:0031012]; microfibril [GO:0001527]; non-collagenous component of basement membrane [GO:0140144]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	GO:0000398; GO:0001527; GO:0005634; GO:0005654; GO:0005684; GO:0005813; GO:0031012; GO:0071005; GO:0140144
GN010017	GN010017.1	Q6DFF6	33.5	236	602	604	9.01e-28	121	KLH20_XENLA	Kelch-like protein 20	Xenopus laevis (African clawed frog)	Golgi to endosome transport [GO:0006895]; negative regulation of apoptotic process [GO:0043066]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K33-linked ubiquitination [GO:1990390]; protein ubiquitination [GO:0016567]	type II interferon binding [GO:0019964]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; trans-Golgi network [GO:0005802]	GO:0005737; GO:0005802; GO:0005829; GO:0006895; GO:0016567; GO:0016605; GO:0019964; GO:0030424; GO:0030425; GO:0031463; GO:0043066; GO:0043161; GO:0048471; GO:1990390; GO:1990756
GN010018	GN010018.1	Q96RT8	36.1	999	922	1024	2.11e-185	565	GCP5_HUMAN	Gamma-tubulin complex component 5 (GCP-5)	Homo sapiens (Human)	meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225]	gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; spindle pole [GO:0000922]	GO:0000278; GO:0000922; GO:0000930; GO:0000931; GO:0005813; GO:0005829; GO:0007020; GO:0008017; GO:0043015; GO:0051225; GO:0051321
GN010035	GN010035.1	Q9DBU3	54.4	480	562	519	1.18e-167	489	RIOK3_MOUSE	Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3)	Mus musculus (Mouse)	cellular response to dsDNA [GO:1990786]; cellular response to dsRNA [GO:0071359]; cellular response to virus [GO:0098586]; maturation of SSU-rRNA [GO:0030490]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of protein-containing complex assembly [GO:0031333]; nonfunctional rRNA decay [GO:0070651]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	ATP binding [GO:0005524]; caspase binding [GO:0089720]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin-modified protein reader activity [GO:0140036]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; preribosome, small subunit precursor [GO:0030688]	GO:0004674; GO:0005524; GO:0005829; GO:0022626; GO:0030490; GO:0030688; GO:0031333; GO:0032728; GO:0039534; GO:0043124; GO:0045089; GO:0070651; GO:0071359; GO:0089720; GO:0098586; GO:0106310; GO:0140036; GO:1990116; GO:1990786
GN010036	GN010036.1	A1E295	61.4	316	341	335	4.40e-145	416	CATB_PIG	Cathepsin B (EC 3.4.22.1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]	Sus scrofa (Pig)	proteolysis [GO:0006508]	cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]	apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; lysosome [GO:0005764]; melanosome [GO:0042470]	GO:0004175; GO:0004197; GO:0005576; GO:0005764; GO:0006508; GO:0016324; GO:0042470
GN010038	GN010038.1	A0T2M3	34.7	150	200	165	8.54e-20	85.1	POLC4_HESAR	Polcalcin Cup a 4 (Calcium-binding pollen allergen Cup a 4) (allergen Cup a 4)	Hesperocyparis arizonica (Arizona cypress) (Cupressus arizonica)		calcium ion binding [GO:0005509]; protein homodimerization activity [GO:0042803]		GO:0005509; GO:0042803
GN010040	GN010040.1	P50549	43.1	485	556	477	3.28e-80	262	ETV1_HUMAN	ETS translocation variant 1 (Ets-related protein 81)	Homo sapiens (Human)	cell differentiation [GO:0030154]; peripheral nervous system neuron development [GO:0048935]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0005634; GO:0006357; GO:0006366; GO:0030154; GO:0045944; GO:0048935; GO:1990837
GN010048	GN010048.1	P18173	33.1	562	967	612	1.46e-85	290	DHGL_DROME	Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]	Drosophila melanogaster (Fruit fly)	glucose metabolic process [GO:0006006]; pupal chitin-based cuticle development [GO:0008364]; sperm storage [GO:0046693]	flavin adenine dinucleotide binding [GO:0050660]; glucose dehydrogenase (FAD, quinone) activity [GO:0140762]; oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0006006; GO:0008364; GO:0016491; GO:0046693; GO:0050660; GO:0140762
GN010049	GN010049.1	Q7YT83	38.0	166	173	300	9.12e-29	110	TX31_CONTE	Cysteine-rich venom protein (CRVP) (EC 3.4.-.-) (Substrate-specific endoprotease Tex31)	Conus textile (Cloth-of-gold cone)			extracellular region [GO:0005576]	GO:0005576
GN010050	GN010050.1	O02703	38.9	185	199	192	1.34e-35	126	BAX_BOVIN	Apoptosis regulator BAX	Bos taurus (Bovine)	apoptotic mitochondrial changes [GO:0008637]; apoptotic signaling pathway [GO:0097190]; B cell apoptotic process [GO:0001783]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of protein binding [GO:0032091]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; regulation of apoptotic process [GO:0042981]; regulation of mitochondrial membrane potential [GO:0051881]; release of cytochrome c from mitochondria [GO:0001836]; release of matrix enzymes from mitochondria [GO:0032976]; response to toxic substance [GO:0009636]	BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]	BAX complex [GO:0097144]; Bcl-2 family protein complex [GO:0097136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pore complex [GO:0046930]	GO:0001783; GO:0001836; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005757; GO:0005783; GO:0005789; GO:0005829; GO:0008053; GO:0008289; GO:0008630; GO:0008637; GO:0009636; GO:0010248; GO:0010917; GO:0015267; GO:0031334; GO:0032091; GO:0032976; GO:0042803; GO:0042981; GO:0043065; GO:0043066; GO:0043525; GO:0043653; GO:0046930; GO:0051434; GO:0051881; GO:0090200; GO:0097136; GO:0097144; GO:0097190; GO:0097192; GO:0097193; GO:2001244
GN010053	GN010053.1	Q9PTU1	47.2	290	337	314	2.39e-56	188	DBX1A_DANRE	Homeobox protein DBX1-A (Developing brain homeobox protein 1-A) (Homeobox protein hlx1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cell differentiation in spinal cord [GO:0021515]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	nucleus [GO:0005634]	GO:0000981; GO:0003677; GO:0005634; GO:0006357; GO:0021515
GN010057	GN010057.1	Q8NB78	45.5	807	793	822	1.69e-247	712	KDM1B_HUMAN	Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B)	Homo sapiens (Human)	genomic imprinting [GO:0071514]; transcription initiation-coupled chromatin remodeling [GO:0045815]	FAD binding [GO:0071949]; FAD-dependent H3K4me/H3K4me3 demethylase activity [GO:0140682]; histone binding [GO:0042393]; histone demethylase activity [GO:0032452]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	GO:0000785; GO:0000786; GO:0005634; GO:0005654; GO:0005694; GO:0008270; GO:0032452; GO:0042393; GO:0045815; GO:0071514; GO:0071949; GO:0140682
GN010059	GN010059.1	Q03172	30.4	322	2372	2688	2.26e-31	139	ZEP1_MOUSE	Zinc finger protein 40 (Alpha A-crystallin-binding protein 1) (Alpha A-CRYBP1) (Alpha A-crystallin-binding protein I) (Transcription factor alphaA-CRYBP1)	Mus musculus (Mouse)	BMP signaling pathway [GO:0030509]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0003677; GO:0005634; GO:0005654; GO:0005739; GO:0005829; GO:0006357; GO:0008270; GO:0016604; GO:0030509; GO:0045892; GO:0045944; GO:0071837; GO:1990837
GN010063	GN010063.1	P48065	45.1	570	625	614	7.20e-178	521	S6A12_HUMAN	Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12)	Homo sapiens (Human)	amino acid transport [GO:0006865]; gamma-aminobutyric acid reuptake [GO:0051936]; gamma-aminobutyric acid transport [GO:0015812]; glycine betaine transport [GO:0031460]; monocarboxylic acid transport [GO:0015718]; sodium ion transmembrane transport [GO:0035725]	amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; glycine betaine:sodium:chloride symporter activity [GO:0140814]; monocarboxylic acid transmembrane transporter activity [GO:0008028]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0005332; GO:0005886; GO:0006865; GO:0008028; GO:0015171; GO:0015718; GO:0015812; GO:0016020; GO:0016323; GO:0031460; GO:0035725; GO:0051936; GO:0098793; GO:0140814
GN010066	GN010066.1	O13997	34.3	102	194	280	2.80e-09	58.5	YIH1_SCHPO	Protein IMPACT homolog	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	cellular response to amino acid starvation [GO:0034198]; GCN2-mediated signaling [GO:0140469]; regulation of cytoplasmic translational initiation in response to stress [GO:1990611]; regulation of translational initiation [GO:0006446]	protein sequestering activity [GO:0140311]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0006446; GO:0034198; GO:0140311; GO:0140469; GO:1990611
GN010068	GN010068.1	Q9Y4A0	25.7	377	784	524	3.72e-11	70.1	JERKL_HUMAN	Jerky protein homolog-like (Human homolog of mouse jerky gene protein) (HHMJG)	Homo sapiens (Human)	central nervous system development [GO:0007417]	DNA binding [GO:0003677]	nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0007417
GN010070	GN010070.1	P20483	55.7	61	74	479	1.10e-18	81.3	MPIP_DROME	M-phase inducer phosphatase (EC 3.1.3.48) (Cdc25-like protein) (Protein string)	Drosophila melanogaster (Fruit fly)	centriole replication [GO:0007099]; G2/M transition of mitotic cell cycle [GO:0000086]; gastrulation [GO:0007369]; Golgi organization [GO:0007030]; histoblast morphogenesis [GO:0007488]; negative regulation of cell size [GO:0045792]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cell cycle, embryonic [GO:0045977]; regulation of mitotic cell cycle [GO:0007346]	protein tyrosine phosphatase activity [GO:0004725]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000086; GO:0004725; GO:0005634; GO:0005694; GO:0005737; GO:0007030; GO:0007099; GO:0007346; GO:0007369; GO:0007488; GO:0008284; GO:0010971; GO:0045792; GO:0045931; GO:0045977; GO:0110032
GN010072	GN010072.1	P20483	53.2	111	121	479	1.16e-33	124	MPIP_DROME	M-phase inducer phosphatase (EC 3.1.3.48) (Cdc25-like protein) (Protein string)	Drosophila melanogaster (Fruit fly)	centriole replication [GO:0007099]; G2/M transition of mitotic cell cycle [GO:0000086]; gastrulation [GO:0007369]; Golgi organization [GO:0007030]; histoblast morphogenesis [GO:0007488]; negative regulation of cell size [GO:0045792]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cell cycle, embryonic [GO:0045977]; regulation of mitotic cell cycle [GO:0007346]	protein tyrosine phosphatase activity [GO:0004725]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000086; GO:0004725; GO:0005634; GO:0005694; GO:0005737; GO:0007030; GO:0007099; GO:0007346; GO:0007369; GO:0007488; GO:0008284; GO:0010971; GO:0045792; GO:0045931; GO:0045977; GO:0110032
GN010073	GN010073.1	P20483	55.7	61	74	479	2.83e-18	80.1	MPIP_DROME	M-phase inducer phosphatase (EC 3.1.3.48) (Cdc25-like protein) (Protein string)	Drosophila melanogaster (Fruit fly)	centriole replication [GO:0007099]; G2/M transition of mitotic cell cycle [GO:0000086]; gastrulation [GO:0007369]; Golgi organization [GO:0007030]; histoblast morphogenesis [GO:0007488]; negative regulation of cell size [GO:0045792]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cell cycle, embryonic [GO:0045977]; regulation of mitotic cell cycle [GO:0007346]	protein tyrosine phosphatase activity [GO:0004725]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000086; GO:0004725; GO:0005634; GO:0005694; GO:0005737; GO:0007030; GO:0007099; GO:0007346; GO:0007369; GO:0007488; GO:0008284; GO:0010971; GO:0045792; GO:0045931; GO:0045977; GO:0110032
GN010074	GN010074.1	P20483	55.7	61	74	479	5.31e-18	79.3	MPIP_DROME	M-phase inducer phosphatase (EC 3.1.3.48) (Cdc25-like protein) (Protein string)	Drosophila melanogaster (Fruit fly)	centriole replication [GO:0007099]; G2/M transition of mitotic cell cycle [GO:0000086]; gastrulation [GO:0007369]; Golgi organization [GO:0007030]; histoblast morphogenesis [GO:0007488]; negative regulation of cell size [GO:0045792]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of G2/MI transition of meiotic cell cycle [GO:0110032]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cell cycle, embryonic [GO:0045977]; regulation of mitotic cell cycle [GO:0007346]	protein tyrosine phosphatase activity [GO:0004725]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000086; GO:0004725; GO:0005634; GO:0005694; GO:0005737; GO:0007030; GO:0007099; GO:0007346; GO:0007369; GO:0007488; GO:0008284; GO:0010971; GO:0045792; GO:0045931; GO:0045977; GO:0110032
GN010076	GN010076.1	Q8CFX1	39.4	777	784	789	1.91e-178	534	G6PE_MOUSE	GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)]	Mus musculus (Mouse)	glucose metabolic process [GO:0006006]; NADP+ metabolic process [GO:0006739]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]; regulation of cortisol biosynthetic process [GO:2000064]; response to alcohol [GO:0097305]; response to nutrient levels [GO:0031667]	6-phosphogluconolactonase activity [GO:0017057]; aldose 1-dehydrogenase activity [GO:0047640]; carbohydrate binding [GO:0030246]; carbonyl reductase (NADPH) activity [GO:0004090]; glucose 1-dehydrogenase (NAD+) activity [GO:0047934]; glucose 1-dehydrogenase (NADP+) activity [GO:0047935]; glucose-6-phosphate dehydrogenase activity [GO:0004345]; NADP binding [GO:0050661]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; sarcoplasmic reticulum [GO:0016529]	GO:0004090; GO:0004345; GO:0005783; GO:0005788; GO:0006006; GO:0006098; GO:0006739; GO:0009051; GO:0016529; GO:0017057; GO:0030246; GO:0031667; GO:0047640; GO:0047934; GO:0047935; GO:0050661; GO:0097305; GO:2000064
GN010077	GN010077.1	Q5REB8	59.3	629	858	686	3.26e-276	783	ACSS3_PONAB	Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 3) (Propionate--CoA ligase) (EC 6.2.1.17)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)		acetyl-CoA synthetase activity [GO:0003987]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; propionate-CoA ligase activity [GO:0050218]	mitochondrial matrix [GO:0005759]	GO:0003987; GO:0005759; GO:0031956; GO:0050218
GN010078	GN010078.1	Q5XH14	65.2	382	383	382	1.20e-176	499	VATC1_XENLA	V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1)	Xenopus laevis (African clawed frog)		proton-transporting ATPase activity, rotational mechanism [GO:0046961]	lysosomal membrane [GO:0005765]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	GO:0000221; GO:0005765; GO:0046961
GN010081	GN010081.1	Q9R0M0	29.8	379	570	2919	4.65e-15	82.8	CELR2_MOUSE	Cadherin EGF LAG seven-pass G-type receptor 2 (Flamingo homolog)	Mus musculus (Mouse)	axonogenesis [GO:0007409]; cell-cell adhesion mediated by cadherin [GO:0044331]; cerebrospinal fluid secretion [GO:0033326]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; dendrite morphogenesis [GO:0048813]; homophilic cell-cell adhesion [GO:0007156]; neural plate anterior/posterior regionalization [GO:0021999]; neuron migration [GO:0001764]; regulation of cell-cell adhesion [GO:0022407]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; ventricular system development [GO:0021591]; Wnt signaling pathway [GO:0016055]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0001764; GO:0003341; GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0005912; GO:0006355; GO:0007156; GO:0007409; GO:0016055; GO:0021591; GO:0021999; GO:0022407; GO:0032880; GO:0033326; GO:0044331; GO:0048813; GO:0060271
GN010082	GN010082.1	P33450	25.3	399	1332	5147	3.41e-15	85.5	FAT_DROME	Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito]	Drosophila melanogaster (Fruit fly)	axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; equator specification [GO:0045317]; establishment of body hair planar orientation [GO:0048105]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of polarity of larval imaginal disc epithelium [GO:0016336]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; imaginal disc-derived wing morphogenesis [GO:0007476]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of growth [GO:0045926]; negative regulation of imaginal disc growth [GO:0045571]; negative regulation of organ growth [GO:0046621]; positive regulation of apoptotic process [GO:0043065]; positive regulation of hippo signaling [GO:0035332]; protein localization involved in establishment of planar polarity [GO:0090251]; pupal development [GO:0035209]; regulation of establishment of planar polarity [GO:0090175]; regulation of growth [GO:0040008]; regulation of imaginal disc growth [GO:0045570]; regulation of protein localization [GO:0032880]; regulation of tube length, open tracheal system [GO:0035159]; tissue development [GO:0009888]; wing disc development [GO:0035220]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0001736; GO:0001737; GO:0005509; GO:0005739; GO:0005886; GO:0005912; GO:0007156; GO:0007157; GO:0007164; GO:0007409; GO:0007446; GO:0007447; GO:0007476; GO:0008285; GO:0009888; GO:0010629; GO:0016324; GO:0016327; GO:0016336; GO:0016339; GO:0030855; GO:0032880; GO:0035159; GO:0035209; GO:0035220; GO:0035332; GO:0040008; GO:0042067; GO:0043065; GO:0044331; GO:0045296; GO:0045317; GO:0045570; GO:0045571; GO:0045926; GO:0046621; GO:0048105; GO:0090175; GO:0090176; GO:0090251; GO:0098609
GN010083	GN010083.1	Q9H0W7	40.0	85	290	228	6.84e-09	58.5	THAP2_HUMAN	THAP domain-containing protein 2	Homo sapiens (Human)			nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730
GN010085	GN010085.1	Q6PD62	78.8	651	674	1173	0.0	1055	CTR9_HUMAN	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1)	Homo sapiens (Human)	cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to lipopolysaccharide [GO:0071222]; chromatin organization [GO:0006325]; endodermal cell fate commitment [GO:0001711]; interleukin-6-mediated signaling pathway [GO:0070102]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]	RNA polymerase II complex binding [GO:0000993]; SH2 domain binding [GO:0042169]	Cdc73/Paf1 complex [GO:0016593]; euchromatin [GO:0000791]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000791; GO:0000993; GO:0001711; GO:0005634; GO:0005654; GO:0006325; GO:0006368; GO:0007259; GO:0016593; GO:0016607; GO:0019827; GO:0042169; GO:0045638; GO:0045944; GO:0070102; GO:0071222
GN010088	GN010088.1	B9EJ86	60.9	711	842	889	4.67e-293	833	OSBL8_MOUSE	Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)	Mus musculus (Mouse)	fat cell differentiation [GO:0045444]; intermembrane phospholipid transfer [GO:0120010]; negative regulation of cell migration [GO:0030336]; phospholipid transport [GO:0015914]; positive regulation of D-glucose import across plasma membrane [GO:0046326]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein localization to nuclear pore [GO:0090204]; triglyceride homeostasis [GO:0070328]	cholesterol binding [GO:0015485]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylserine binding [GO:0001786]; phosphatidylserine transfer activity [GO:0140343]; phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity [GO:0160270]	cortical endoplasmic reticulum [GO:0032541]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; transporter complex [GO:1990351]	GO:0001786; GO:0005783; GO:0005789; GO:0005829; GO:0015485; GO:0015914; GO:0016020; GO:0030336; GO:0031965; GO:0032541; GO:0045444; GO:0046326; GO:0046628; GO:0051897; GO:0070273; GO:0070328; GO:0090204; GO:0120010; GO:0140268; GO:0140343; GO:0160270; GO:1990351
GN010089	GN010089.1	Q4R6K2	41.3	445	435	505	2.14e-92	291	ZNT1_MACFA	Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	defense response to bacterium [GO:0042742]; detoxification of zinc ion [GO:0010312]; intracellular zinc ion homeostasis [GO:0006882]; zinc export across plasma membrane [GO:0140882]; zinc ion import into organelle [GO:0062111]	calcium channel inhibitor activity [GO:0019855]; zinc:proton antiporter activity [GO:0140826]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	GO:0000139; GO:0005737; GO:0005789; GO:0005886; GO:0006882; GO:0010312; GO:0014069; GO:0016323; GO:0019855; GO:0030659; GO:0031965; GO:0042742; GO:0062111; GO:0140826; GO:0140882
GN010090	GN010090.1	Q7KM13	61.1	175	298	425	5.20e-58	194	HEY_DROME	Hairy/enhancer-of-split related with YRPW motif protein	Drosophila melanogaster (Fruit fly)	anterior/posterior pattern specification [GO:0009952]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate determination [GO:0048664]; Notch signaling pathway [GO:0007219]; regulation of neurogenesis [GO:0050767]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0003677; GO:0005634; GO:0007219; GO:0009952; GO:0046983; GO:0048664; GO:0050767
GN010093	GN010093.1	A0A1S4GHV7	36.2	304	407	493	2.00e-47	172	FUTA_ANOGA	Core alpha-(1,3)-fucosyltransferase (EC 2.4.1.214) (Fucosyltransferase A) (AgFucTA)	Anopheles gambiae (African malaria mosquito)	N-glycan processing [GO:0006491]	glycoprotein 3-alpha-L-fucosyltransferase activity [GO:0018392]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0018392; GO:0032580
GN010094	GN010094.1	Q9UIG8	30.0	597	658	710	2.52e-75	258	SO3A1_HUMAN	Solute carrier organic anion transporter family member 3A1 (OATP3A1) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (Organic anion-transporting polypeptide D) (OATP-D) (PGE1 transporter) (Sodium-independent organic anion transporter D) (Solute carrier family 21 member 11)	Homo sapiens (Human)	phenylalanine transport [GO:0015823]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of MAPK cascade [GO:0043410]; prostaglandin transport [GO:0015732]; sodium-independent organic anion transport [GO:0043252]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828]	prostaglandin transmembrane transporter activity [GO:0015132]; secondary active transmembrane transporter activity [GO:0015291]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005886; GO:0009925; GO:0015132; GO:0015291; GO:0015732; GO:0015823; GO:0015827; GO:0015828; GO:0016323; GO:0016324; GO:0022857; GO:0043123; GO:0043252; GO:0043410; GO:0055085; GO:0150104
GN010098	GN010098.1	Q8MQJ9	28.9	201	297	1037	4.69e-10	63.9	BRAT_DROME	Protein brain tumor	Drosophila melanogaster (Fruit fly)	asymmetric cell division [GO:0008356]; asymmetric neuroblast division resulting in ganglion mother cell formation [GO:0055060]; brain development [GO:0007420]; ganglion mother cell fate determination [GO:0007402]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of translation [GO:0017148]; neural precursor cell proliferation [GO:0061351]; neuroblast development [GO:0014019]; neuroblast differentiation [GO:0014016]; neuroblast fate determination [GO:0007400]; neuroblast proliferation [GO:0007405]; neuron differentiation [GO:0030182]; oogenesis [GO:0048477]; regulation of neuroblast proliferation [GO:1902692]; regulation of neurogenesis [GO:0050767]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of translation [GO:0006417]; rRNA transcription [GO:0009303]; segmentation [GO:0035282]; ventral cord development [GO:0007419]	mRNA 3'-UTR binding [GO:0003730]; translation regulator activity [GO:0045182]; translation repressor activity [GO:0030371]; zinc ion binding [GO:0008270]	apical cortex [GO:0045179]; basal cortex [GO:0045180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]	GO:0003730; GO:0005737; GO:0005829; GO:0006417; GO:0007400; GO:0007402; GO:0007405; GO:0007406; GO:0007419; GO:0007420; GO:0008270; GO:0008285; GO:0008356; GO:0008582; GO:0009303; GO:0010629; GO:0014016; GO:0014019; GO:0017148; GO:0030182; GO:0030371; GO:0035282; GO:0043025; GO:0045179; GO:0045180; GO:0045182; GO:0048477; GO:0050767; GO:0055060; GO:0061351; GO:1900242; GO:1902692
GN010099	GN010099.1	G2QDQ9	28.4	476	499	574	2.25e-38	150	VAO15_THET4	VAO-type flavoprotein oxidase VAO615	Thermothelomyces thermophilus (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)		FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491; GO:0071949
GN010100	GN010100.1	A0A0E0RTV6	27.1	461	500	565	5.75e-36	144	ZEB1_GIBZE	FAD-linked oxidoreductase ZEB1 (EC 1.-.-.-) (Zearalenone biosynthesis protein 1)	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)	zearalenone biosynthetic process [GO:0106150]	FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]		GO:0016491; GO:0071949; GO:0106150
GN010101	GN010101.1	A0R4Q3	41.0	205	301	266	5.31e-36	133	ECH19_MYCS2	Enoyl-CoA hydratase EchA19 (EC 4.2.1.-)	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)	cholesterol catabolic process [GO:0006707]; fatty acid beta-oxidation [GO:0006635]	catalytic activity [GO:0003824]		GO:0003824; GO:0006635; GO:0006707
GN010105	GN010105.1	A0A0E0RTV6	26.4	450	396	565	1.81e-34	137	ZEB1_GIBZE	FAD-linked oxidoreductase ZEB1 (EC 1.-.-.-) (Zearalenone biosynthesis protein 1)	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)	zearalenone biosynthetic process [GO:0106150]	FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]		GO:0016491; GO:0071949; GO:0106150
GN010106	GN010106.1	G2QDQ9	26.8	574	538	574	6.41e-39	153	VAO15_THET4	VAO-type flavoprotein oxidase VAO615	Thermothelomyces thermophilus (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)		FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491; GO:0071949
GN010107	GN010107.1	A0A0E0RTV6	26.9	461	500	565	6.89e-35	140	ZEB1_GIBZE	FAD-linked oxidoreductase ZEB1 (EC 1.-.-.-) (Zearalenone biosynthesis protein 1)	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)	zearalenone biosynthetic process [GO:0106150]	FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]		GO:0016491; GO:0071949; GO:0106150
GN010108	GN010108.1	Q8CEE6	31.1	1153	1051	1383	8.24e-117	395	PASK_MOUSE	PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (EC 2.7.11.1)	Mus musculus (Mouse)	energy homeostasis [GO:0097009]; intracellular signal transduction [GO:0035556]; negative regulation of glycogen biosynthetic process [GO:0045719]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; regulation of glucagon secretion [GO:0070092]; regulation of respiratory gaseous exchange [GO:0043576]	ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006355; GO:0006468; GO:0035091; GO:0035556; GO:0043576; GO:0045719; GO:0046777; GO:0070092; GO:0097009; GO:0106310
GN010109	GN010109.1	Q6DDK3	28.7	272	453	308	3.00e-30	122	DOXA1_XENLA	Dual oxidase maturation factor 1 (Dual oxidase activator 1)	Xenopus laevis (African clawed frog)	protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]		apical plasma membrane [GO:0016324]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0005789; GO:0015031; GO:0016020; GO:0016324; GO:0072659
GN010110	GN010110.1	Q9XSM3	25.2	507	1248	730	1.08e-16	89.4	TRPV5_RABIT	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Epithelial calcium channel 1) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3)	Oryctolagus cuniculus (Rabbit)	calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; protein homotetramerization [GO:0051289]; regulation of urine volume [GO:0035809]	calcium channel activity [GO:0005262]; identical protein binding [GO:0042802]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0005262; GO:0005886; GO:0006816; GO:0016324; GO:0035809; GO:0042802; GO:0051289; GO:0055074; GO:0070588; GO:0098703
GN010111	GN010111.1	Q8WUD4	66.7	93	106	166	1.85e-31	111	CCD12_HUMAN	Coiled-coil domain-containing protein 12	Homo sapiens (Human)			nucleoplasm [GO:0005654]; post-mRNA release spliceosomal complex [GO:0071014]; U2-type spliceosomal complex [GO:0005684]	GO:0005654; GO:0005684; GO:0071014
GN010113	GN010113.1	Q9DG68	69.2	315	315	315	1.31e-137	395	RLA0_LITSY	Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (60S ribosomal protein L10E)	Lithobates sylvaticus (Wood frog) (Rana sylvatica)	cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027]	large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]	GO:0000027; GO:0002181; GO:0003735; GO:0022625; GO:0070180
GN010114	GN010114.1	Q71MB6	40.6	630	722	724	2.16e-163	491	SO4C1_RAT	Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20)	Rattus norvegicus (Rat)	sodium-independent organic anion transport [GO:0043252]; transmembrane transport [GO:0055085]	secondary active transmembrane transporter activity [GO:0015291]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]	GO:0015291; GO:0016323; GO:0016324; GO:0022857; GO:0043252; GO:0055085
GN010116	GN010116.1	Q8K354	38.6	280	284	277	2.53e-62	201	CBR3_MOUSE	Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10)	Mus musculus (Mouse)	cognition [GO:0050890]; phylloquinone catabolic process [GO:0042376]	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity [GO:0000253]; carbonyl reductase (NADPH) activity [GO:0004090]; NADPH binding [GO:0070402]; NADPH dehydrogenase (quinone) activity [GO:0008753]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0000253; GO:0004090; GO:0005654; GO:0005737; GO:0005829; GO:0008753; GO:0042376; GO:0050890; GO:0070402
GN010117	GN010117.1	Q96KE9	32.5	265	314	538	1.98e-34	134	BTBD6_HUMAN	BTB/POZ domain-containing protein 6 (Lens BTB domain protein)	Homo sapiens (Human)	neurogenesis [GO:0022008]		cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0022008
GN010118	GN010118.1	H2A0N4	25.8	524	660	1014	4.22e-53	200	PIF_PINMG	Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)]	Margaritifera margaritifera (Freshwater pearl mussel)		chitin binding [GO:0008061]	extracellular region [GO:0005576]	GO:0005576; GO:0008061
GN010119	GN010119.1	Q8CJ96	48.1	133	625	419	7.51e-26	114	RASF8_MOUSE	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1 homolog)	Mus musculus (Mouse)	signal transduction [GO:0007165]			GO:0007165
GN010120	GN010120.1	Q6IV56	38.1	210	230	222	4.57e-49	163	RN141_DANRE	RING finger protein 141	Danio rerio (Zebrafish) (Brachydanio rerio)		ubiquitin-protein transferase activity [GO:0004842]		GO:0004842
GN010121	GN010121.1	Q9D4C1	39.5	233	1122	413	1.02e-36	147	LMTD1_MOUSE	Lamin tail domain-containing protein 1 (Intermediate filament tail domain-containing protein 1) (Lamin-A-related sequence 1 protein)	Mus musculus (Mouse)	cell population proliferation [GO:0008283]		cytoplasm [GO:0005737]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]	GO:0005634; GO:0005635; GO:0005737; GO:0008283
GN010124	GN010124.1	P86437	30.9	136	141	193	2.57e-11	61.6	CBLN1_BOVIN	Cerebellin-1 (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin]	Bos taurus (Bovine)	cerebellar granule cell differentiation [GO:0021707]; heterophilic cell-cell adhesion [GO:0007157]; maintenance of synapse structure [GO:0099558]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of inhibitory synapse assembly [GO:1905703]; positive regulation of long-term synaptic depression [GO:1900454]; regulation of postsynaptic density assembly [GO:0099151]; regulation of presynapse assembly [GO:1905606]; synapse organization [GO:0050808]; trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission [GO:0099557]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]; signaling receptor regulator activity [GO:0030545]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic membrane [GO:0045211]; synaptic cleft [GO:0043083]; trans-synaptic protein complex [GO:0098820]	GO:0005576; GO:0007157; GO:0021707; GO:0030545; GO:0042802; GO:0043083; GO:0045211; GO:0050808; GO:0090394; GO:0098688; GO:0098820; GO:0098978; GO:0099151; GO:0099550; GO:0099557; GO:0099558; GO:1900454; GO:1905606; GO:1905703
GN010127	GN010127.1	Q9JJW0	57.3	143	145	212	4.61e-55	174	PXMP4_MOUSE	Peroxisomal membrane protein 4 (24 kDa peroxisomal intrinsic membrane protein)	Mus musculus (Mouse)	ether lipid metabolic process [GO:0046485]		peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0005777; GO:0005778; GO:0046485
GN010130	GN010130.1	Q29RP8	57.5	261	246	393	6.42e-101	301	KMT5B_BOVIN	Histone-lysine N-methyltransferase KMT5B (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361)	Bos taurus (Bovine)	DNA repair [GO:0006281]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]	chromatin binding [GO:0003682]; histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; histone methyltransferase activity [GO:0042054]; S-adenosyl-L-methionine binding [GO:1904047]	chromosome [GO:0005694]; nucleus [GO:0005634]	GO:0003682; GO:0005634; GO:0005694; GO:0006281; GO:0042054; GO:0042799; GO:0045830; GO:0140941; GO:0140944; GO:1904047; GO:2001034
GN010132	GN010132.1	Q9IA95	36.8	174	209	315	1.11e-24	101	SFRP3_CHICK	Secreted frizzled-related protein 3 (sFRP-3) (Frizzled-related protein 1) (FrzB-1)	Gallus gallus (Chicken)	canonical Wnt signaling pathway [GO:0060070]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell differentiation [GO:0014033]; non-canonical Wnt signaling pathway [GO:0035567]; regulation of cell differentiation [GO:0045595]; somite development [GO:0061053]	Wnt-protein binding [GO:0017147]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	GO:0005576; GO:0005737; GO:0008285; GO:0014033; GO:0017147; GO:0030178; GO:0030308; GO:0035567; GO:0045595; GO:0060070; GO:0061053; GO:0090090
GN010133	GN010133.1	Q6Q899	32.6	685	1059	926	1.20e-89	311	RIGI_MOUSE	Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mRNA transcription [GO:0009299]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; ruffle membrane [GO:0032587]	GO:0002230; GO:0002735; GO:0002753; GO:0003690; GO:0003724; GO:0003725; GO:0003727; GO:0005524; GO:0005525; GO:0005737; GO:0005829; GO:0005886; GO:0005923; GO:0008270; GO:0009299; GO:0009597; GO:0009615; GO:0010467; GO:0010628; GO:0015629; GO:0016887; GO:0030334; GO:0031625; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0032760; GO:0038187; GO:0039529; GO:0042802; GO:0043330; GO:0045087; GO:0045944; GO:0051607; GO:0060760; GO:0071360; GO:0140374; GO:1990904
GN010134	GN010134.1	O95786	33.0	533	791	925	5.68e-76	268	RIGI_HUMAN	Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; gene expression [GO:0010467]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell migration [GO:0030334]; regulation of type III interferon production [GO:0034344]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; ruffle membrane [GO:0032587]	GO:0002230; GO:0002735; GO:0002753; GO:0003690; GO:0003724; GO:0003725; GO:0003727; GO:0005524; GO:0005525; GO:0005737; GO:0005829; GO:0005886; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010467; GO:0010628; GO:0015629; GO:0016887; GO:0030334; GO:0031625; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0032760; GO:0034344; GO:0038187; GO:0039529; GO:0042802; GO:0043330; GO:0045087; GO:0045944; GO:0051607; GO:0060760; GO:0071360; GO:0140374; GO:1990904
GN010135	GN010135.1	Q6Q899	35.9	697	1148	926	2.92e-103	350	RIGI_MOUSE	Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mRNA transcription [GO:0009299]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; ruffle membrane [GO:0032587]	GO:0002230; GO:0002735; GO:0002753; GO:0003690; GO:0003724; GO:0003725; GO:0003727; GO:0005524; GO:0005525; GO:0005737; GO:0005829; GO:0005886; GO:0005923; GO:0008270; GO:0009299; GO:0009597; GO:0009615; GO:0010467; GO:0010628; GO:0015629; GO:0016887; GO:0030334; GO:0031625; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0032760; GO:0038187; GO:0039529; GO:0042802; GO:0043330; GO:0045087; GO:0045944; GO:0051607; GO:0060760; GO:0071360; GO:0140374; GO:1990904
GN010137	GN010137.1	Q09388	33.0	664	662	627	3.55e-76	259	ACM2_CAEEL	Muscarinic acetylcholine receptor gar-2 (G protein-linked acetylcholine receptor 2)	Caenorhabditis elegans	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway [GO:0007197]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of synaptic transmission, cholinergic [GO:0032223]; response to xenobiotic stimulus [GO:0009410]	G protein-coupled acetylcholine receptor activity [GO:0016907]	axon [GO:0030424]; dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0005886; GO:0007186; GO:0007187; GO:0007197; GO:0007268; GO:0009410; GO:0016907; GO:0030424; GO:0030425; GO:0032223; GO:0045202
GN010140	GN010140.1	Q6DJB3	51.2	373	576	443	3.62e-137	409	DEFI8_XENTR	Differentially expressed in FDCP 8 homolog (DEF-8)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	lysosome localization [GO:0032418]; positive regulation of bone resorption [GO:0045780]; positive regulation of ruffle assembly [GO:1900029]			GO:0032418; GO:0045780; GO:1900029
GN010141	GN010141.1	P24032	69.2	172	189	172	6.89e-79	235	MLRN_CHICK	Myosin regulatory light chain 2, smooth muscle minor isoform (MLC-2) (DTNB) (G1) (Isoform L20-B1)	Gallus gallus (Chicken)		calcium ion binding [GO:0005509]; myosin heavy chain binding [GO:0032036]	cytoplasm [GO:0005737]; myosin II complex [GO:0016460]	GO:0005509; GO:0005737; GO:0016460; GO:0032036
GN010142	GN010142.1	Q5ZJK1	47.4	647	670	698	2.14e-180	532	THOC5_CHICK	THO complex subunit 5 homolog	Gallus gallus (Chicken)	mRNA export from nucleus [GO:0006406]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; THO complex part of transcription export complex [GO:0000445]	GO:0000445; GO:0003729; GO:0005737; GO:0006406
GN010143	GN010143.1	Q6UX01	53.7	354	378	489	4.54e-110	333	LMBRL_HUMAN	Protein LMBR1L (Limb region 1 protein homolog-like) (Lipocalin-1-interacting membrane receptor) (LIMR)	Homo sapiens (Human)	hematopoietic stem cell differentiation [GO:0060218]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165]; T cell apoptotic process [GO:0070231]; T cell differentiation [GO:0030217]; T cell proliferation [GO:0042098]	transmembrane signaling receptor activity [GO:0004888]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0004888; GO:0005789; GO:0005886; GO:0006898; GO:0007165; GO:0030217; GO:0042098; GO:0060218; GO:0070231; GO:0090090
GN010144	GN010144.1	Q6A4L1	43.6	714	705	721	6.13e-187	551	S12A8_XENLA	Solute carrier family 12 member 8	Xenopus laevis (African clawed frog)	cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]	potassium:chloride symporter activity [GO:0015379]	apical plasma membrane [GO:0016324]	GO:0006884; GO:0015379; GO:0016324; GO:0055064; GO:0055075; GO:0071805; GO:1990573
GN010145	GN010145.1	Q9CXS4	66.4	128	139	252	1.85e-61	192	CENPV_MOUSE	Centromere protein V (CENP-V) (Proline-rich protein 6)	Mus musculus (Mouse)	ameboidal-type cell migration [GO:0001667]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; meiotic metaphase chromosome alignment [GO:0051311]; pericentric heterochromatin formation [GO:0031508]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of cytokinesis [GO:0032467]; regulation of chromosome organization [GO:0033044]; spindle assembly [GO:0051225]	carbon-sulfur lyase activity [GO:0016846]; microtubule binding [GO:0008017]	chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; spindle midzone [GO:0051233]	GO:0000775; GO:0000776; GO:0001667; GO:0005634; GO:0005654; GO:0005730; GO:0005815; GO:0005829; GO:0005876; GO:0007059; GO:0008017; GO:0015630; GO:0016846; GO:0030496; GO:0031508; GO:0031965; GO:0032467; GO:0033044; GO:0040038; GO:0051225; GO:0051233; GO:0051311; GO:0051382
GN010146	GN010146.1	P10826	29.3	348	659	455	7.16e-35	141	RARB_HUMAN	Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon)	Homo sapiens (Human)	cell differentiation [GO:0030154]; embryonic digestive tract development [GO:0048566]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; retinoic acid receptor signaling pathway [GO:0048384]; signal transduction [GO:0007165]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000785; GO:0000978; GO:0000981; GO:0003677; GO:0004879; GO:0005634; GO:0005654; GO:0005737; GO:0007165; GO:0008270; GO:0030154; GO:0045944; GO:0048384; GO:0048566; GO:0090575; GO:1990837
GN010151	GN010151.1	O00222	25.8	283	826	908	5.42e-23	108	GRM8_HUMAN	Metabotropic glutamate receptor 8 (mGluR8)	Homo sapiens (Human)	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; regulation of synaptic transmission, glutamatergic [GO:0051966]; visual perception [GO:0007601]	G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]	plasma membrane [GO:0005886]	GO:0001642; GO:0004930; GO:0005886; GO:0007193; GO:0007196; GO:0007216; GO:0007601; GO:0008066; GO:0051966
GN010152	GN010152.1	Q8IXX5	33.9	280	298	376	1.76e-44	158	T183A_HUMAN	Transmembrane protein 183A	Homo sapiens (Human)			membrane [GO:0016020]; SCF ubiquitin ligase complex [GO:0019005]	GO:0016020; GO:0019005
GN010154	GN010154.1	P48147	65.5	705	707	710	0.0	1001	PPCE_HUMAN	Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme)	Homo sapiens (Human)	angiotensin maturation [GO:0002003]; proteolysis [GO:0006508]	metallocarboxypeptidase activity [GO:0004181]; oligopeptidase activity [GO:0070012]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0002003; GO:0004181; GO:0004252; GO:0005576; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0008236; GO:0016020; GO:0070012
GN010155	GN010155.1	Q29RK9	72.5	200	225	216	3.90e-116	333	MOB3B_BOVIN	MOB kinase activator 3B (Mob1 homolog 2b) (Mps one binder kinase activator-like 2B)	Bos taurus (Bovine)	regulation of hippo signaling [GO:0035330]	protein kinase activator activity [GO:0030295]		GO:0030295; GO:0035330
GN010156	GN010156.1	P53470	79.5	376	380	376	2.34e-230	635	ACT1_SCHMA	Actin-1 (EC 3.6.4.-)	Schistosoma mansoni (Blood fluke)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN010159	GN010159.1	P04464	31.0	145	161	149	1.19e-18	80.5	CALM_WHEAT	Calmodulin (CaM)	Triticum aestivum (Wheat)		calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]	GO:0005509; GO:0005737; GO:0019904; GO:0030234
GN010162	GN010162.1	Q5RJQ0	29.7	172	188	411	4.73e-15	75.5	CHST1_RAT	Carbohydrate sulfotransferase 1 (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1) (GST-1) (Keratan sulfate Gal-6 sulfotransferase) (KS6ST) (KSGal6ST) (KSST) (EC 2.8.2.21)	Rattus norvegicus (Rat)	galactose metabolic process [GO:0006012]; keratan sulfate proteoglycan biosynthetic process [GO:0018146]; keratan sulfate proteoglycan metabolic process [GO:0042339]; N-acetylglucosamine metabolic process [GO:0006044]; sulfur compound metabolic process [GO:0006790]	keratan sulfotransferase activity [GO:0045130]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]	GO:0000139; GO:0001517; GO:0006012; GO:0006044; GO:0006790; GO:0008146; GO:0018146; GO:0042339; GO:0045130
GN010163	GN010163.1	O45035	34.6	127	143	132	2.66e-10	57.8	FABP_SCHJA	Fatty acid-binding protein (Sj-FABPc) (Sj14FABP)	Schistosoma japonicum (Blood fluke)		lipid binding [GO:0008289]	cytoplasm [GO:0005737]	GO:0005737; GO:0008289
GN010164	GN010164.1	Q9BX70	24.9	433	396	525	2.53e-19	93.2	BTBD2_HUMAN	BTB/POZ domain-containing protein 2	Homo sapiens (Human)	neurogenesis [GO:0022008]		cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; P-body [GO:0000932]	GO:0000932; GO:0005737; GO:0005829; GO:0022008; GO:0036464
GN010166	GN010166.1	V5NAL9	33.3	693	655	899	1.45e-102	335	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN010168	GN010168.1	V5NAL9	33.1	178	185	899	6.52e-35	132	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN010169	GN010169.1	V5NAL9	29.7	279	318	899	2.60e-33	133	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN010171	GN010171.1	Q15119	48.8	387	433	407	1.01e-122	365	PDK2_HUMAN	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)	Homo sapiens (Human)	cellular response to nutrient [GO:0031670]; cellular response to reactive oxygen species [GO:0034614]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; regulation of gluconeogenesis [GO:0006111]; regulation of glucose metabolic process [GO:0010906]; regulation of ketone metabolic process [GO:0010565]; regulation of pH [GO:0006885]; regulation of pyruvate decarboxylation to acetyl-CoA [GO:0010510]	ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254]	GO:0004672; GO:0004740; GO:0005524; GO:0005739; GO:0005759; GO:0006006; GO:0006111; GO:0006885; GO:0008286; GO:0010510; GO:0010565; GO:0010906; GO:0031670; GO:0034614; GO:0042593; GO:0042803; GO:0045254; GO:0072332
GN010175	GN010175.1	Q8VDK3	36.5	115	800	253	1.45e-17	86.7	ELF5_MOUSE	ETS-related transcription factor Elf-5 (E74-like factor 5)	Mus musculus (Mouse)	cell differentiation [GO:0030154]; ectoderm development [GO:0007398]; ectodermal cell fate commitment [GO:0001712]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of cell differentiation [GO:0045596]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0001228; GO:0001712; GO:0005634; GO:0005737; GO:0006357; GO:0007398; GO:0030154; GO:0035019; GO:0045596; GO:0045944; GO:0060644; GO:1990837
GN010178	GN010178.1	Q7T3B0	53.2	308	320	375	1.47e-110	328	EIF3M_DANRE	Eukaryotic translation initiation factor 3 subunit M (eIF3m)	Danio rerio (Zebrafish) (Brachydanio rerio)	cytoplasmic translational initiation [GO:0002183]; formation of cytoplasmic translation initiation complex [GO:0001732]	translation initiation factor activity [GO:0003743]	eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]	GO:0001732; GO:0002183; GO:0003743; GO:0005852; GO:0016282; GO:0033290; GO:0071541
GN010186	GN010186.1	P82890	47.6	145	159	155	1.99e-40	136	PPAC1_DROME	Low molecular weight phosphotyrosine protein phosphatase 1 (EC 3.1.3.48) (Low molecular weight cytosolic acid phosphatase 1) (EC 3.1.3.2) (PTPase 1)	Drosophila melanogaster (Fruit fly)		acid phosphatase activity [GO:0003993]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003993; GO:0004725; GO:0004726; GO:0005634; GO:0005737
GN010187	GN010187.1	F6UF99	29.3	246	427	387	1.43e-17	87.4	TM237_XENTR	Transmembrane protein 237	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cilium assembly [GO:0060271]; regulation of Wnt signaling pathway [GO:0030111]		ciliary transition zone [GO:0035869]; membrane [GO:0016020]	GO:0016020; GO:0030111; GO:0035869; GO:0060271
GN010192	GN010192.1	Q7T2C4	31.3	766	812	739	3.98e-118	377	S26A5_DANRE	Prestin (Solute carrier family 26 member 5)	Danio rerio (Zebrafish) (Brachydanio rerio)	chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; oxalate transport [GO:0019532]; regulation of membrane potential [GO:0042391]; sulfate transmembrane transport [GO:1902358]	chloride:bicarbonate antiporter activity [GO:0140900]; formate transmembrane transporter activity [GO:0015499]; monoatomic ion transmembrane transporter activity [GO:0015075]; oxalate transmembrane transporter activity [GO:0019531]; oxalate:chloride antiporter activity [GO:0160046]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:chloride antiporter activity [GO:0160044]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0006821; GO:0008271; GO:0015075; GO:0015116; GO:0015499; GO:0016020; GO:0019531; GO:0019532; GO:0042391; GO:0140900; GO:0160044; GO:0160046; GO:1902358; GO:1902476
GN010194	GN010194.1	Q7T2C4	37.2	443	469	739	4.64e-85	279	S26A5_DANRE	Prestin (Solute carrier family 26 member 5)	Danio rerio (Zebrafish) (Brachydanio rerio)	chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; oxalate transport [GO:0019532]; regulation of membrane potential [GO:0042391]; sulfate transmembrane transport [GO:1902358]	chloride:bicarbonate antiporter activity [GO:0140900]; formate transmembrane transporter activity [GO:0015499]; monoatomic ion transmembrane transporter activity [GO:0015075]; oxalate transmembrane transporter activity [GO:0019531]; oxalate:chloride antiporter activity [GO:0160046]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; sulfate:chloride antiporter activity [GO:0160044]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0006821; GO:0008271; GO:0015075; GO:0015116; GO:0015499; GO:0016020; GO:0019531; GO:0019532; GO:0042391; GO:0140900; GO:0160044; GO:0160046; GO:1902358; GO:1902476
GN010195	GN010195.1	A0FKN5	31.1	655	683	742	1.54e-74	258	S26A5_CHICK	Prestin (Solute carrier family 26 member 5)	Gallus gallus (Chicken)		oxalate:chloride antiporter activity [GO:0160046]; sulfate:chloride antiporter activity [GO:0160044]	plasma membrane [GO:0005886]	GO:0005886; GO:0160044; GO:0160046
GN010196	GN010196.1	Q6UX65	37.9	161	182	266	3.73e-31	116	DRAM2_HUMAN	DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77)	Homo sapiens (Human)	photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601]		apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; photoreceptor inner segment [GO:0001917]	GO:0001917; GO:0005737; GO:0005764; GO:0005765; GO:0005794; GO:0007601; GO:0010506; GO:0016324; GO:0045494
GN010197	GN010197.1	Q15699	51.3	193	319	326	2.78e-44	157	ALX1_HUMAN	ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1)	Homo sapiens (Human)	embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000785; GO:0000977; GO:0000981; GO:0001228; GO:0005634; GO:0005654; GO:0005667; GO:0010718; GO:0016604; GO:0045892; GO:0045893; GO:0045944; GO:0048666; GO:0048704; GO:1990837
GN010198	GN010198.1	Q172Y1	39.6	154	231	306	3.26e-26	106	MED30_AEDAE	Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	positive regulation of DNA-templated transcription [GO:0045893]	transcription coregulator activity [GO:0003712]	mediator complex [GO:0016592]	GO:0003712; GO:0016592; GO:0045893
GN010199	GN010199.1	P13706	67.5	354	390	360	1.12e-173	491	GPDA_DROME	Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)	Drosophila melanogaster (Fruit fly)	ethanol metabolic process [GO:0006067]; flight behavior [GO:0007629]; glycerol-3-phosphate biosynthetic process [GO:0046167]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerol-3-phosphate shuttle [GO:0006127]; glycerophospholipid metabolic process [GO:0006650]; glycolytic process [GO:0006096]; response to hyperoxia [GO:0055093]; triglyceride metabolic process [GO:0006641]	glycerol-3-phosphate dehydrogenase (NAD+) activity [GO:0141152]; glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952]; NAD binding [GO:0051287]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; M band [GO:0031430]; Z disc [GO:0030018]	GO:0005737; GO:0005829; GO:0006067; GO:0006072; GO:0006096; GO:0006127; GO:0006641; GO:0006650; GO:0007629; GO:0030018; GO:0031430; GO:0042803; GO:0046167; GO:0046168; GO:0047952; GO:0051287; GO:0055093; GO:0141152
GN010200	GN010200.1	P78318	33.5	275	345	339	1.41e-44	159	IGBP1_HUMAN	Immunoglobulin-binding protein 1 (B-cell signal transduction molecule alpha 4) (Protein alpha-4) (CD79a-binding protein 1) (Protein phosphatase 2/4/6 regulatory subunit) (Renal carcinoma antigen NY-REN-16)	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of microtubule-based movement [GO:0060632]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]	protein phosphatase regulator activity [GO:0019888]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0000122; GO:0005737; GO:0005829; GO:0007165; GO:0019888; GO:0032873; GO:0034612; GO:0035556; GO:0060632; GO:0070555
GN010202	GN010202.1	Q1L8G7	50.7	229	274	242	5.92e-74	229	GATD1_DANRE	GATA zinc finger domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	chromatin organization [GO:0006325]; regulation of DNA-templated transcription [GO:0006355]	sequence-specific DNA binding [GO:0043565]	I band [GO:0031674]; nucleus [GO:0005634]	GO:0005634; GO:0006325; GO:0006355; GO:0031674; GO:0043565
GN010203	GN010203.1	Q3SZ20	65.3	461	594	504	4.32e-225	635	GLYM_BOVIN	Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)	Bos taurus (Bovine)	glycine metabolic process [GO:0006544]; L-serine metabolic process [GO:0006563]; one-carbon metabolic process [GO:0006730]; protein homotetramerization [GO:0051289]; protein K63-linked deubiquitination [GO:0070536]; protein tetramerization [GO:0051262]; regulation of aerobic respiration [GO:1903715]; regulation of mitochondrial translation [GO:0070129]; regulation of oxidative phosphorylation [GO:0002082]; response to type I interferon [GO:0034340]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	chromatin binding [GO:0003682]; glycine hydroxymethyltransferase activity [GO:0004372]; pyridoxal phosphate binding [GO:0030170]	BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0002082; GO:0003682; GO:0004372; GO:0005634; GO:0005737; GO:0005739; GO:0005743; GO:0005759; GO:0006544; GO:0006563; GO:0006730; GO:0030170; GO:0034340; GO:0035999; GO:0042645; GO:0046653; GO:0051262; GO:0051289; GO:0070129; GO:0070536; GO:0070552; GO:1903715
GN010206	GN010206.1	Q56R14	35.1	134	590	1091	1.60e-11	71.2	TRI33_XENLA	E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)	Xenopus laevis (African clawed frog)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0008270; GO:0016567; GO:0061630
GN010208	GN010208.1	Q95WY5	33.7	540	635	580	1.17e-100	321	MALT_CULPI	Alpha-glucosidase (EC 3.2.1.20) (Binary toxin-binding alpha-glucosidase) (Culex pipiens maltase 1) (Cpm1)	Culex pipiens (House mosquito)	carbohydrate metabolic process [GO:0005975]	alpha-1,4-glucosidase activity [GO:0004558]	membrane [GO:0016020]	GO:0004558; GO:0005975; GO:0016020
GN010210	GN010210.1	A0A0E0SNE8	29.8	121	287	323	1.89e-13	72.8	ERG3B_GIBZE	Delta(7)-sterol 5(6)-desaturase ERG3B (EC 1.14.19.20) (C-5 sterol desaturase ERG3B) (Ergosterol Delta(5,6) desaturase ERG3B) (Ergosterol biosynthetic protein 3B)	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)	sterol biosynthetic process [GO:0016126]	delta7-sterol 5(6)-desaturase activity [GO:0050046]; iron ion binding [GO:0005506]	endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005789; GO:0016126; GO:0050046
GN010212	GN010212.1	P31478	73.1	119	122	124	2.13e-59	181	VATF_MANSE	V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F)	Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)		proton-transporting ATPase activity, rotational mechanism [GO:0046961]	proton-transporting V-type ATPase, V1 domain [GO:0033180]	GO:0033180; GO:0046961
GN010213	GN010213.1	Q6P135	36.4	165	391	292	4.04e-22	98.6	TMUB1_DANRE	Transmembrane and ubiquitin-like domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	ERAD pathway [GO:0036503]		cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0016020; GO:0036503
GN010214	GN010214.1	A2AUY4	32.8	1365	2205	2123	8.76e-145	504	BAZ2B_MOUSE	Bromodomain adjacent to zinc finger domain protein 2B	Mus musculus (Mouse)		DNA binding [GO:0003677]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0003677; GO:0005634
GN010215	GN010215.1	Q8N9V3	49.0	496	505	476	1.68e-70	235	WSDU1_HUMAN	WD repeat, SAM and U-box domain-containing protein 1	Homo sapiens (Human)	protein ubiquitination [GO:0016567]	ubiquitin-protein transferase activity [GO:0004842]		GO:0004842; GO:0016567
GN010217	GN010217.1	Q00969	35.7	504	611	487	1.33e-55	199	ATF2_RAT	Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (cAMP response element-binding protein CRE-BP1)	Rattus norvegicus (Rat)	abducens nucleus development [GO:0021742]; adipose tissue development [GO:0060612]; amelogenesis [GO:0097186]; apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; brainstem development [GO:0003360]; cellular response to anisomycin [GO:0072740]; cellular response to leucine starvation [GO:1990253]; cellular response to oxidative stress [GO:0034599]; cellular response to virus [GO:0098586]; detection of cell density [GO:0060245]; DNA damage response [GO:0006974]; facial nucleus development [GO:0021754]; fat cell differentiation [GO:0045444]; gene expression [GO:0010467]; growth plate cartilage chondrocyte differentiation [GO:0003418]; growth plate cartilage chondrocyte proliferation [GO:0003419]; heart development [GO:0007507]; hematopoietic progenitor cell differentiation [GO:0002244]; hepatocyte apoptotic process [GO:0097284]; hypoglossal nucleus development [GO:0021743]; in utero embryonic development [GO:0001701]; intracellular glucose homeostasis [GO:0001678]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; JNK cascade [GO:0007254]; lipid metabolic process [GO:0006629]; liver development [GO:0001889]; MAPK cascade [GO:0000165]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; motor neuron apoptotic process [GO:0097049]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of angiogenesis [GO:0016525]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurofilament cytoskeleton organization [GO:0060052]; NK T cell differentiation [GO:0001865]; outflow tract morphogenesis [GO:0003151]; p38MAPK cascade [GO:0038066]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle myoblast proliferation [GO:0110024]; positive regulation of gene expression [GO:0010628]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta2 production [GO:0032915]; protein import into nucleus [GO:0006606]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to osmotic stress [GO:0006970]; transcription initiation-coupled chromatin remodeling [GO:0045815]; vacuole organization [GO:0007033]; white fat cell differentiation [GO:0050872]	cAMP response element binding [GO:0035497]; cAMP response element binding protein binding [GO:0008140]; chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone H2B acetyltransferase activity [GO:0044013]; histone H4 acetyltransferase activity [GO:0010485]; identical protein binding [GO:0042802]; leucine zipper domain binding [GO:0043522]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	CCAAT-binding factor complex [GO:0016602]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; H4 histone acetyltransferase complex [GO:1902562]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000122; GO:0000165; GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0000987; GO:0001228; GO:0001678; GO:0001701; GO:0001865; GO:0001889; GO:0001934; GO:0002244; GO:0003151; GO:0003360; GO:0003418; GO:0003419; GO:0003677; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005741; GO:0006355; GO:0006357; GO:0006606; GO:0006629; GO:0006915; GO:0006970; GO:0006974; GO:0007033; GO:0007254; GO:0007507; GO:0008140; GO:0010467; GO:0010485; GO:0010628; GO:0016020; GO:0016525; GO:0016602; GO:0018107; GO:0019901; GO:0021742; GO:0021743; GO:0021754; GO:0030509; GO:0031573; GO:0032915; GO:0034599; GO:0035497; GO:0035861; GO:0038066; GO:0042789; GO:0042802; GO:0042803; GO:0043522; GO:0043525; GO:0043565; GO:0044013; GO:0044877; GO:0045444; GO:0045815; GO:0045944; GO:0046982; GO:0050680; GO:0050872; GO:0060052; GO:0060245; GO:0060612; GO:0061629; GO:0072740; GO:0097049; GO:0097186; GO:0097284; GO:0098586; GO:0110024; GO:1902110; GO:1902562; GO:1990144; GO:1990253; GO:1990837; GO:1990841
GN010218	GN010218.1	Q11082	22.4	304	385	434	3.93e-09	61.6	YT66_CAEEL	Probable G protein-coupled receptor B0563.6	Caenorhabditis elegans		G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886
GN010219	GN010219.1	Q5RBP9	40.6	579	716	716	1.48e-143	439	MPEG1_PONAB	Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2) [Cleaved into: Macrophage-expressed gene 1 protein, processed form]	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	antibacterial innate immune response [GO:0140367]; antigen processing and presentation of exogenous peptide antigen [GO:0002478]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; dendritic cell antigen processing and presentation [GO:0002468]	wide pore channel activity [GO:0022829]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagolysosome membrane [GO:0061474]	GO:0002468; GO:0002478; GO:0022829; GO:0030659; GO:0030670; GO:0031410; GO:0042590; GO:0042742; GO:0045335; GO:0050829; GO:0050830; GO:0061474; GO:0140367
GN010220	GN010220.1	Q9P2N4	31.5	108	126	1935	7.08e-09	55.8	ATS9_HUMAN	A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-)	Homo sapiens (Human)	aorta morphogenesis [GO:0035909]; endothelial cell-matrix adhesion [GO:0090673]; extracellular matrix organization [GO:0030198]; heart valve morphogenesis [GO:0003179]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of sprouting angiogenesis [GO:1903671]; proteolysis [GO:0006508]; ventricular cardiac muscle tissue development [GO:0003229]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]	GO:0003179; GO:0003229; GO:0004222; GO:0005783; GO:0006508; GO:0008237; GO:0008270; GO:0009986; GO:0010596; GO:0030198; GO:0031012; GO:0035909; GO:0090673; GO:1903671
GN010222	GN010222.1	P50476	56.0	150	322	388	2.12e-38	143	HOX3_XENLA	Homeobox protein XHOX-3	Xenopus laevis (African clawed frog)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357
GN010223	GN010223.1	P50476	51.7	176	232	388	1.32e-36	135	HOX3_XENLA	Homeobox protein XHOX-3	Xenopus laevis (African clawed frog)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357
GN010225	GN010225.1	Q5M9G1	38.8	196	282	356	9.87e-27	110	HEXI1_RAT	Protein HEXIM1 (Cardiac lineage protein 1)	Rattus norvegicus (Rat)	activation of innate immune response [GO:0002218]; heart development [GO:0007507]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of viral transcription [GO:0032897]; positive regulation of signal transduction by p53 class mediator [GO:1901798]	7SK snRNA binding [GO:0097322]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; identical protein binding [GO:0042802]; P-TEFb complex binding [GO:0106140]; protein kinase inhibitor activity [GO:0004860]; snRNA binding [GO:0017069]; transcription regulator inhibitor activity [GO:0140416]	7SK snRNP [GO:0120259]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0002218; GO:0004860; GO:0004861; GO:0005634; GO:0005654; GO:0005737; GO:0007507; GO:0017069; GO:0032897; GO:0034244; GO:0042802; GO:0045892; GO:0097322; GO:0106140; GO:0120259; GO:0140416; GO:1901798
GN010226	GN010226.1	Q9WU78	50.8	744	908	869	2.88e-245	713	PDC6I_MOUSE	Programmed cell death 6-interacting protein (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (E2F1-inducible protein) (Eig2)	Mus musculus (Mouse)	actomyosin contractile ring assembly [GO:0000915]; apoptotic process [GO:0006915]; bicellular tight junction assembly [GO:0070830]; extracellular exosome biogenesis [GO:0097734]; macroautophagy [GO:0016236]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; protein homooligomerization [GO:0051260]; regulation of centrosome duplication [GO:0010824]; regulation of extracellular exosome assembly [GO:1903551]; regulation of membrane permeability [GO:0090559]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]	calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; proteinase activated receptor binding [GO:0031871]; SH3 domain binding [GO:0017124]	actomyosin [GO:0042641]; bicellular tight junction [GO:0005923]; centrosome [GO:0005813]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; immunological synapse [GO:0001772]; melanosome [GO:0042470]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]	GO:0000281; GO:0000915; GO:0001772; GO:0005813; GO:0005829; GO:0005923; GO:0006915; GO:0010824; GO:0016236; GO:0017124; GO:0031871; GO:0039702; GO:0042470; GO:0042641; GO:0042802; GO:0042803; GO:0043025; GO:0043209; GO:0045199; GO:0046755; GO:0046983; GO:0048306; GO:0048471; GO:0051260; GO:0061952; GO:0070062; GO:0070830; GO:0070971; GO:0090543; GO:0090559; GO:0090611; GO:0097734; GO:1903543; GO:1903551; GO:1903553
GN010227	GN010227.1	Q00534	61.1	293	331	326	2.70e-134	387	CDK6_HUMAN	Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)	Homo sapiens (Human)	astrocyte development [GO:0014002]; cell dedifferentiation [GO:0043697]; dentate gyrus development [GO:0021542]; DNA damage response [GO:0006974]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; generation of neurons [GO:0048699]; gliogenesis [GO:0042063]; hemopoiesis [GO:0030097]; lateral ventricle development [GO:0021670]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cellular senescence [GO:2000773]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of cell cycle [GO:0051726]; regulation of cell motility [GO:2000145]; regulation of erythrocyte differentiation [GO:0045646]; regulation of gene expression [GO:0010468]; response to virus [GO:0009615]; type B pancreatic cell development [GO:0003323]	ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; FBXO family protein binding [GO:0098770]; protein serine kinase activity [GO:0106310]	centrosome [GO:0005813]; cyclin D1-CDK6 complex [GO:0097131]; cyclin D2-CDK6 complex [GO:0097132]; cyclin D3-CDK6 complex [GO:0097133]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ruffle [GO:0001726]	GO:0000082; GO:0000086; GO:0000307; GO:0001726; GO:0001954; GO:0003323; GO:0004693; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0006974; GO:0008285; GO:0009615; GO:0010468; GO:0014002; GO:0021542; GO:0021670; GO:0030097; GO:0030332; GO:0042063; GO:0043697; GO:0045596; GO:0045638; GO:0045646; GO:0045656; GO:0045668; GO:0045786; GO:0048146; GO:0048699; GO:0050680; GO:0051726; GO:0097131; GO:0097132; GO:0097133; GO:0098770; GO:0106310; GO:2000145; GO:2000773
GN010229	GN010229.1	Q8BHL8	39.1	284	277	271	6.10e-57	186	PSMF1_MOUSE	Proteasome inhibitor PI31 subunit	Mus musculus (Mouse)	negative regulation of proteasomal protein catabolic process [GO:1901799]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511]	endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]	GO:0004866; GO:0005783; GO:0005829; GO:0006511; GO:0042803; GO:0043161; GO:0046982; GO:0048471; GO:0070628; GO:1901799
GN010230	GN010230.1	Q6NS23	45.3	424	446	478	9.33e-126	376	TRM11_XENLA	tRNA (guanine(10)-N(2))-methyltransferase TRMT11 (EC 2.1.1.214) (tRNA methyltransferase 11 homolog)	Xenopus laevis (African clawed frog)		methyltransferase activity [GO:0008168]; nucleic acid binding [GO:0003676]; tRNA (guanine(10)-N2)-methyltransferase activity [GO:0160102]	cytoplasm [GO:0005737]; tRNA (m2G10) methyltransferase complex [GO:0043528]	GO:0003676; GO:0005737; GO:0008168; GO:0043528; GO:0160102
GN010231	GN010231.1	Q6TGY8	48.9	280	290	297	1.49e-86	263	EMC2_DANRE	ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein insertion into ER membrane by stop-transfer membrane-anchor sequence [GO:0045050]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]		cytoplasm [GO:0005737]; EMC complex [GO:0072546]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of endoplasmic reticulum membrane [GO:0042406]	GO:0005737; GO:0005783; GO:0005789; GO:0042406; GO:0045050; GO:0071816; GO:0072546
GN010232	GN010232.1	Q26630	78.8	259	257	260	4.69e-131	374	IDLC_STRPU	33 kDa inner dynein arm light chain, axonemal (p33)	Strongylocentrotus purpuratus (Purple sea urchin)		dynein heavy chain binding [GO:0045504]	axoneme [GO:0005930]; ciliary base [GO:0097546]	GO:0005930; GO:0045504; GO:0097546
GN010233	GN010233.1	B5X4E0	56.4	328	338	316	1.63e-115	340	CALUB_SALSA	Calumenin-B	Salmo salar (Atlantic salmon)		calcium ion binding [GO:0005509]	endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; sarcoplasmic reticulum lumen [GO:0033018]	GO:0005509; GO:0005576; GO:0005789; GO:0005794; GO:0033018; GO:0042470
GN010234	GN010234.1	Q8INF0	40.6	591	602	1097	3.96e-143	445	GCY8E_DROME	Soluble guanylate cyclase 88E (EC 4.6.1.2)	Drosophila melanogaster (Fruit fly)	nitric oxide-cGMP-mediated signaling [GO:0038060]; response to hypoxia [GO:0001666]; response to oxygen levels [GO:0070482]; response to reactive oxygen species [GO:0000302]	carbon monoxide binding [GO:0070025]; enzyme binding [GO:0019899]; GTPase activity [GO:0003924]; guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; nitric oxide binding [GO:0070026]; oxygen binding [GO:0019825]; oxygen sensor activity [GO:0019826]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	guanylate cyclase complex, soluble [GO:0008074]	GO:0000302; GO:0001666; GO:0003924; GO:0004383; GO:0008074; GO:0019825; GO:0019826; GO:0019899; GO:0020037; GO:0038060; GO:0042803; GO:0046982; GO:0070025; GO:0070026; GO:0070482
GN010235	GN010235.1	Q3SZZ7	45.7	230	356	312	1.16e-58	195	FGL1_BOVIN	Fibrinogen-like protein 1	Bos taurus (Bovine)	blood coagulation [GO:0007596]; hepatocyte proliferation [GO:0072574]; negative regulation of T cell activation [GO:0050868]; regulation of immune response [GO:0050776]	receptor ligand activity [GO:0048018]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0007596; GO:0031012; GO:0048018; GO:0050776; GO:0050868; GO:0072574
GN010236	GN010236.1	G3HKI1	29.2	178	349	327	2.63e-14	76.3	XRCC4_CRIGR	DNA repair protein XRCC4 (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)]	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	base-excision repair [GO:0006284]; DNA double-strand break attachment to nuclear envelope [GO:1990683]; double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; protein localization to site of double-strand break [GO:1990166]; response to X-ray [GO:0010165]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; FHA domain binding [GO:0070975]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0003677; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005829; GO:0005958; GO:0006284; GO:0006303; GO:0010165; GO:0019899; GO:0030674; GO:0032807; GO:0033152; GO:0035861; GO:0042802; GO:0070975; GO:1990166; GO:1990683
GN010237	GN010237.1	Q8SQA4	25.9	370	1225	734	1.88e-09	65.9	AGRE5_BOVIN	Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta]	Bos taurus (Bovine)	cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0004930; GO:0005509; GO:0005576; GO:0005886; GO:0007166; GO:0007186
GN010238	GN010238.1	Q7RYZ9	29.6	335	305	333	1.12e-39	144	T7H_NEUCR	Thymine-7-hydroxylase (T7H) (THase) (EC 1.14.11.6) (2-oxoglutarate-Fe(II) type oxidoreductase) (Thymine dioxygenase)	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)				
GN010239	GN010239.1	Q8CJH3	46.7	90	166	2119	1.40e-17	82.4	PLXB1_MOUSE	Plexin-B1	Mus musculus (Mouse)	inhibitory synapse assembly [GO:1904862]; negative regulation of cell adhesion [GO:0007162]; negative regulation of osteoblast proliferation [GO:0033689]; neuron projection morphogenesis [GO:0048812]; ossification involved in bone maturation [GO:0043931]; positive regulation of axonogenesis [GO:0050772]; positive regulation of GTPase activity [GO:0043547]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416]	GTPase activating protein binding [GO:0032794]; semaphorin receptor activity [GO:0017154]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; semaphorin receptor complex [GO:0002116]	GO:0002116; GO:0005576; GO:0005886; GO:0007162; GO:0007416; GO:0008360; GO:0017154; GO:0030334; GO:0032794; GO:0033689; GO:0035025; GO:0043547; GO:0043931; GO:0045211; GO:0048812; GO:0050772; GO:0051493; GO:0051897; GO:0071526; GO:0098978; GO:1904862
GN010240	GN010240.1	Q5TKA1	54.4	533	516	542	8.66e-182	524	LIN9_HUMAN	Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein)	Homo sapiens (Human)	DNA-templated transcription [GO:0006351]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]	DRM complex [GO:0070176]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0006357; GO:0045892; GO:0045944; GO:0051726; GO:0070176; GO:0090575
GN010250	GN010250.1	Q6T308	67.7	626	637	699	0.0	913	GLGB_FELCA	1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme)	Felis catus (Cat) (Felis silvestris catus)	glycogen biosynthetic process [GO:0005978]	1,4-alpha-glucan branching enzyme activity [GO:0003844]; cation binding [GO:0043169]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0003844; GO:0004553; GO:0005737; GO:0005829; GO:0005978; GO:0043169
GN010252	GN010252.1	P86854	27.6	152	193	156	2.94e-15	72.8	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN010253	GN010253.1	Q96EK6	37.8	180	197	184	6.96e-39	134	GNA1_HUMAN	Glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase)	Homo sapiens (Human)	UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	glucosamine 6-phosphate N-acetyltransferase activity [GO:0004343]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]	GO:0000139; GO:0004343; GO:0005829; GO:0006048; GO:0010008; GO:0042802
GN010254	GN010254.1	O75762	26.8	441	1114	1119	1.92e-15	85.5	TRPA1_HUMAN	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor)	Homo sapiens (Human)	calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to caffeine [GO:0071313]; cellular response to carbon dioxide [GO:0071244]; cellular response to cold [GO:0070417]; cellular response to food [GO:0071240]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to toxic substance [GO:0097237]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transport [GO:0006811]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of monoatomic anion transport [GO:1903793]; protein homotetramerization [GO:0051289]; regulation of blood circulation [GO:1903522]; regulation of neuronal action potential [GO:0098908]; response to cold [GO:0009409]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]; ureteric peristalsis [GO:0072105]; urinary bladder smooth muscle contraction [GO:0014832]; vasodilation [GO:0042311]	calcium channel activity [GO:0005262]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]; temperature-gated cation channel activity [GO:0097604]; voltage-gated calcium channel activity [GO:0005245]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]	GO:0005245; GO:0005262; GO:0005886; GO:0006811; GO:0006874; GO:0007166; GO:0009409; GO:0014832; GO:0015267; GO:0015278; GO:0016324; GO:0019233; GO:0030424; GO:0032421; GO:0034605; GO:0035774; GO:0042311; GO:0042802; GO:0050955; GO:0050968; GO:0050974; GO:0051289; GO:0070301; GO:0070417; GO:0070588; GO:0071240; GO:0071244; GO:0071313; GO:0072105; GO:0097237; GO:0097553; GO:0097604; GO:0098908; GO:1903522; GO:1903793; GO:1990760
GN010257	GN010257.1	Q5M9G9	24.5	335	600	629	1.89e-13	77.0	FAKD4_RAT	FAST kinase domain-containing protein 4 (Protein TBRG4) (Transforming growth factor beta regulator 4)	Rattus norvegicus (Rat)	mitochondrial mRNA processing [GO:0090615]; mitochondrial RNA processing [GO:0000963]; mRNA metabolic process [GO:0016071]; regulation of mitochondrial mRNA stability [GO:0044528]		mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]	GO:0000963; GO:0005739; GO:0005759; GO:0016071; GO:0035770; GO:0044528; GO:0090615
GN010258	GN010258.1	Q15404	81.9	149	177	277	4.60e-37	132	RSU1_HUMAN	Ras suppressor protein 1 (RSP-1) (Rsu-1)	Homo sapiens (Human)	cell-matrix adhesion [GO:0007160]; Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165]		cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]	GO:0005829; GO:0005925; GO:0007160; GO:0007165; GO:0007265; GO:0070062
GN010259	GN010259.1	A7RWD2	76.6	321	333	327	4.78e-68	219	CIAO1_NEMVE	Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog	Nematostella vectensis (Starlet sea anemone)	iron-sulfur cluster assembly [GO:0016226]; protein maturation [GO:0051604]		cytosolic [4Fe-4S] assembly targeting complex [GO:0097361]	GO:0016226; GO:0051604; GO:0097361
GN010261	GN010261.1	B7K079	70.0	207	254	217	3.76e-110	319	MSRA_RIPO1	Peptide methionine sulfoxide reductase MsrA (Protein-methionine-S-oxide reductase) (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase)	Rippkaea orientalis (strain PCC 8801 / RF-1) (Cyanothece sp. (strain PCC 8801))	cellular response to oxidative stress [GO:0034599]	L-methionine (S)-S-oxide reductase activity [GO:0033744]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113]	cytoplasm [GO:0005737]	GO:0005737; GO:0008113; GO:0033744; GO:0034599
GN010263	GN010263.1	Q5XJQ7	54.0	113	329	264	3.67e-23	99.8	OSR1_DANRE	Protein odd-skipped-related 1 (zOsr1)	Danio rerio (Zebrafish) (Brachydanio rerio)	angioblast cell differentiation [GO:0035779]; intermediate mesoderm development [GO:0048389]; kidney development [GO:0001822]; mesendoderm development [GO:0048382]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; pattern specification process [GO:0007389]; pectoral fin development [GO:0033339]; podocyte development [GO:0072015]; podocyte differentiation [GO:0072112]; pronephric distal tubule development [GO:0035777]; pronephric glomerulus morphogenesis [GO:0035775]; pronephric nephron tubule epithelial cell differentiation [GO:0035778]; pronephric proximal tubule development [GO:0035776]; pronephros development [GO:0048793]; regulation of endodermal cell differentiation [GO:1903224]; regulation of nodal signaling pathway [GO:1900107]; urogenital system development [GO:0001655]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000122; GO:0000977; GO:0000981; GO:0001655; GO:0001822; GO:0005634; GO:0007389; GO:0033339; GO:0035775; GO:0035776; GO:0035777; GO:0035778; GO:0035779; GO:0045892; GO:0048382; GO:0048389; GO:0048793; GO:0072015; GO:0072112; GO:1900107; GO:1903224
GN010264	GN010264.1	Q6DGE9	42.5	949	939	934	2.95e-245	716	UN45B_DANRE	Protein unc-45 homolog B (Unc-45B) (UNC45-related protein)	Danio rerio (Zebrafish) (Brachydanio rerio)	cardiac muscle tissue development [GO:0048738]; lens development in camera-type eye [GO:0002088]; muscle cell development [GO:0055001]; myofibril assembly [GO:0030239]; protein folding [GO:0006457]; skeletal muscle organ development [GO:0060538]; skeletal muscle tissue development [GO:0007519]; striated muscle cell development [GO:0055002]	Hsp90 protein binding [GO:0051879]	A band [GO:0031672]; cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018]	GO:0002088; GO:0005737; GO:0006457; GO:0007519; GO:0030018; GO:0030239; GO:0031672; GO:0048471; GO:0048738; GO:0051879; GO:0055001; GO:0055002; GO:0060538
GN010265	GN010265.1	B3A0P5	41.5	217	377	419	2.42e-45	164	GEPRP_LOTGI	Glycine, glutamate and proline-rich protein	Lottia gigantea (Giant owl limpet)	peptidoglycan catabolic process [GO:0009253]	lysozyme activity [GO:0003796]	extracellular region [GO:0005576]	GO:0003796; GO:0005576; GO:0009253
GN010277	GN010277.1	Q8IYB1	26.6	418	407	491	4.56e-25	110	M21D2_HUMAN	Nucleotidyltransferase MB21D2 (EC 2.7.7.-) (Mab-21 domain-containing protein 2) (hMB21D2)	Homo sapiens (Human)		cadherin binding [GO:0045296]; protein-containing complex binding [GO:0044877]		GO:0044877; GO:0045296
GN010278	GN010278.1	A5WVX9	44.7	235	259	620	7.30e-69	226	ZDH17_DANRE	Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (Zinc finger DHHC domain-containing protein 17)	Danio rerio (Zebrafish) (Brachydanio rerio)	axonogenesis [GO:0007409]; habituation [GO:0046959]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]	protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]	cytoplasmic vesicle membrane [GO:0030659]; Golgi membrane [GO:0000139]; presynaptic membrane [GO:0042734]	GO:0000139; GO:0007409; GO:0019705; GO:0019706; GO:0030659; GO:0042734; GO:0046959; GO:0051386; GO:0070372; GO:0140439
GN010279	GN010279.1	E9PTT0	51.6	337	377	622	4.08e-90	286	ZDH17_RAT	Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 17)	Rattus norvegicus (Rat)	axonogenesis [GO:0007409]; lipoprotein transport [GO:0042953]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of modification of synapse structure, modulating synaptic transmission [GO:0098987]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]; regulation of programmed cell death [GO:0043067]	identical protein binding [GO:0042802]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]; signaling receptor binding [GO:0005102]	cytoplasmic vesicle membrane [GO:0030659]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; perforant pathway to dendrate granule cell synapse [GO:0140240]; postsynaptic Golgi apparatus [GO:0150051]; presynaptic membrane [GO:0042734]	GO:0000139; GO:0005102; GO:0005794; GO:0007409; GO:0016409; GO:0018230; GO:0018345; GO:0019705; GO:0019706; GO:0030659; GO:0030660; GO:0042734; GO:0042802; GO:0042953; GO:0043067; GO:0051386; GO:0070372; GO:0098978; GO:0098987; GO:0140240; GO:0140439; GO:0150051
GN010282	GN010282.1	O95238	45.0	249	395	335	1.55e-55	189	SPDEF_HUMAN	SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor)	Homo sapiens (Human)	cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000981; GO:0005634; GO:0006357; GO:0030154; GO:0043065; GO:0043565; GO:1990837
GN010283	GN010283.1	Q9WTP3	36.6	287	447	325	5.09e-47	167	SPDEF_MOUSE	SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor)	Mus musculus (Mouse)	cell differentiation [GO:0030154]; intestinal epithelial cell development [GO:0060576]; lung goblet cell differentiation [GO:0060480]; negative regulation of cell fate commitment [GO:0010454]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell fate commitment [GO:0010455]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]	GO:0000122; GO:0000981; GO:0005634; GO:0006357; GO:0010454; GO:0010455; GO:0030154; GO:0043065; GO:0043565; GO:0045944; GO:0060480; GO:0060576; GO:1990837
GN010285	GN010285.1	B2GUP8	60.4	598	668	688	3.77e-239	681	MITOS_XENTR	Mitochondrial potassium channel ATP-binding subunit (ATP-binding cassette sub-family B member 8, mitochondrial) (ABCB8) (Mitochondrial sulfonylurea-receptor) (MITOSUR)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	oligopeptide export from mitochondrion [GO:0090374]; potassium ion transmembrane transport [GO:0071805]	ABC-type oligopeptide transporter activity [GO:0015421]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	mitochondrial ATP-gated potassium channel complex [GO:0062157]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005524; GO:0005739; GO:0005743; GO:0015421; GO:0016887; GO:0062157; GO:0071805; GO:0090374
GN010286	GN010286.1	Q5TC84	47.9	211	369	451	4.12e-62	208	OGRL1_HUMAN	Opioid growth factor receptor-like protein 1	Homo sapiens (Human)		opioid growth factor receptor activity [GO:0140625]	membrane [GO:0016020]	GO:0016020; GO:0140625
GN010296	GN010296.1	Q6DJN2	30.7	567	603	556	2.29e-78	261	TRF6B_XENLA	TNF receptor-associated factor 6-B (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6-B)	Xenopus laevis (African clawed frog)	activation of NF-kappaB-inducing kinase activity [GO:0007250]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]	signaling adaptor activity [GO:0035591]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; nucleus [GO:0005634]	GO:0004842; GO:0005164; GO:0005634; GO:0005737; GO:0005811; GO:0005938; GO:0007250; GO:0008270; GO:0009898; GO:0031663; GO:0035591; GO:0042981; GO:0043122; GO:0045087; GO:0061630; GO:0070534; GO:0098978
GN010299	GN010299.1	P48180	29.8	225	374	498	2.27e-28	119	ACH1_CAEEL	Acetylcholine receptor subunit alpha-type acr-16	Caenorhabditis elegans	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; cell projection [GO:0042995]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0042995; GO:0043005; GO:0045202; GO:0045211
GN010300	GN010300.1	Q6AXJ7	33.6	220	301	374	8.00e-19	89.0	F199X_DANRE	Protein FAM199X	Danio rerio (Zebrafish) (Brachydanio rerio)				
GN010304	GN010304.1	Q9FT72	27.8	389	413	713	5.08e-27	117	RQL3_ARATH	ATP-dependent DNA helicase Q-like 3 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ3) (RecQ-like protein 3) (AtRecQ3) (AtRecQl3)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004386; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006310; GO:0009378; GO:0016887; GO:0043138; GO:1990814
GN010305	GN010305.1	Q3SZR9	28.7	143	185	253	8.14e-11	62.4	TSN3_BOVIN	Tetraspanin-3 (Tspan-3)	Bos taurus (Bovine)			plasma membrane [GO:0005886]	GO:0005886
GN010306	GN010306.1	Q1LVN8	58.0	169	158	692	8.76e-60	199	SELO1_DANRE	Protein adenylyltransferase SelO-1, mitochondrial (EC 2.7.7.108) (Selenoprotein O) (SelO)	Danio rerio (Zebrafish) (Brachydanio rerio)		AMPylase activity [GO:0070733]	mitochondrion [GO:0005739]	GO:0005739; GO:0070733
GN010307	GN010307.1	O45782	24.5	306	322	426	7.67e-15	78.2	ARD17_CAEEL	Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1)	Caenorhabditis elegans		molecular adaptor activity [GO:0060090]; protein phosphatase 2B binding [GO:0030346]	cytoplasm [GO:0005737]	GO:0005737; GO:0030346; GO:0060090
GN010310	GN010310.1	Q5T5Y3	27.2	1868	1788	1602	4.11e-93	338	CAMP1_HUMAN	Calmodulin-regulated spectrin-associated protein 1	Homo sapiens (Human)	microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; regulation of microtubule polymerization [GO:0031113]	calmodulin binding [GO:0005516]; microtubule binding [GO:0008017]; microtubule minus-end binding [GO:0051011]; spectrin binding [GO:0030507]	cytosol [GO:0005829]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]	GO:0000226; GO:0005516; GO:0005829; GO:0005874; GO:0008017; GO:0030507; GO:0031113; GO:0031175; GO:0051011; GO:0072686
GN010311	GN010311.1	Q0V9M0	50.5	364	365	647	2.38e-105	326	CRAC1_XENTR	Cartilage acidic protein 1 (ASPIC)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	axonal fasciculation [GO:0007413]	calcium ion binding [GO:0005509]		GO:0005509; GO:0007413
GN010313	GN010313.1	P09496	41.5	229	206	248	2.19e-43	148	CLCA_HUMAN	Clathrin light chain A (Lca)	Homo sapiens (Human)	chromosome segregation [GO:0007059]; clathrin coat assembly [GO:0048268]; clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; mitotic spindle organization [GO:0007052]; synaptic vesicle endocytosis [GO:0048488]	clathrin heavy chain binding [GO:0032050]; GTPase binding [GO:0051020]; peptide binding [GO:0042277]; protein-containing complex binding [GO:0044877]; structural molecule activity [GO:0005198]	clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin vesicle coat [GO:0030125]; clathrin-coated endocytic vesicle [GO:0045334]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome [GO:0005768]; kinetochore microtubule [GO:0005828]; lysosome [GO:0005764]; membrane [GO:0016020]; mitotic spindle microtubule [GO:1990498]; plasma membrane [GO:0005886]; postsynaptic endocytic zone [GO:0098843]; presynaptic endocytic zone membrane [GO:0098835]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network membrane [GO:0032588]	GO:0000278; GO:0005198; GO:0005764; GO:0005768; GO:0005828; GO:0005829; GO:0005886; GO:0006886; GO:0007052; GO:0007059; GO:0016020; GO:0030118; GO:0030125; GO:0030130; GO:0030132; GO:0030672; GO:0031410; GO:0032050; GO:0032588; GO:0036020; GO:0042277; GO:0044877; GO:0045334; GO:0048268; GO:0048488; GO:0051020; GO:0071439; GO:0072318; GO:0072583; GO:0098835; GO:0098843; GO:1990498
GN010314	GN010314.1	Q5QJ74	28.3	491	538	424	1.49e-43	163	TBCEL_HUMAN	Tubulin-specific chaperone cofactor E-like protein (EL) (Leucine-rich repeat-containing protein 35)	Homo sapiens (Human)	microtubule cytoskeleton organization [GO:0000226]; post-chaperonin tubulin folding pathway [GO:0007023]; tubulin complex assembly [GO:0007021]	alpha-tubulin binding [GO:0043014]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	GO:0000226; GO:0005737; GO:0005856; GO:0007021; GO:0007023; GO:0043014
GN010315	GN010315.1	Q8VIK1	63.8	80	134	123	8.82e-26	97.1	SNR25_MOUSE	U11/U12 small nuclear ribonucleoprotein 25 kDa protein (U11/U12 snRNP 25 kDa protein)	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]		cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U11/U12 snRNP [GO:0034693]; U12-type precatalytic spliceosome [GO:0071016]; U12-type spliceosomal complex [GO:0005689]	GO:0000398; GO:0005634; GO:0005654; GO:0005681; GO:0005689; GO:0005829; GO:0034693; GO:0045171; GO:0071016
GN010324	GN010324.1	Q96EQ9	41.9	136	333	843	2.26e-24	107	PRDM9_MOUSE	Histone-lysine N-methyltransferase PRDM9 (Hybrid sterility protein 1) (Meiosis-induced factor containing a PR/SET domain and zinc-finger motif) (PR domain zinc finger protein 9) (PR domain-containing protein 9) (Protein-lysine N-methyltransferase PRDM9) (EC 2.1.1.-) ([histone H3]-lysine36 N-trimethyltransferase PRDM9) (EC 2.1.1.359) ([histone H3]-lysine4 N-trimethyltransferase PRDM9) (EC 2.1.1.354) ([histone H3]-lysine9 N-trimethyltransferase PRDM9) (EC 2.1.1.355) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.361)	Mus musculus (Mouse)	double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; male gamete generation [GO:0048232]; meiotic gene conversion [GO:0006311]; negative regulation of apoptotic process [GO:0043066]; positive regulation of fertilization [GO:1905516]; positive regulation of meiosis I [GO:0060903]; positive regulation of reciprocal meiotic recombination [GO:0010845]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283]	histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; protein homodimerization activity [GO:0042803]; protein-lysine N-methyltransferase activity [GO:0016279]; recombination hotspot binding [GO:0010844]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000976; GO:0005634; GO:0005654; GO:0005694; GO:0006311; GO:0007129; GO:0007283; GO:0007292; GO:0008270; GO:0010468; GO:0010844; GO:0010845; GO:0016279; GO:0042800; GO:0042803; GO:0043066; GO:0043565; GO:0045944; GO:0046975; GO:0048232; GO:0060903; GO:0140941; GO:0140944; GO:0140949; GO:0140955; GO:0140999; GO:1905516; GO:1990918
GN010325	GN010325.1	Q7ZVG6	80.8	260	270	282	7.05e-160	448	SIAH1_DANRE	E3 ubiquitin-protein ligase Siah1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1)	Danio rerio (Zebrafish) (Brachydanio rerio)	neuron apoptotic process [GO:0051402]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016567; GO:0031624; GO:0043161; GO:0051402; GO:0061630
GN010326	GN010326.1	Q6UXI9	33.3	126	805	565	1.54e-09	65.1	NPNT_HUMAN	Nephronectin (Preosteoblast EGF-like repeat protein with MAM domain) (Protein EGFL6-like)	Homo sapiens (Human)	branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell adhesion mediated by integrin [GO:0033631]; cell-matrix adhesion [GO:0007160]; cellular response to tumor necrosis factor [GO:0071356]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of osteoblast differentiation [GO:0045669]; ureteric bud development [GO:0001657]	calcium ion binding [GO:0005509]; integrin binding [GO:0005178]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0001657; GO:0001658; GO:0005178; GO:0005509; GO:0005576; GO:0007160; GO:0010811; GO:0016020; GO:0030198; GO:0031012; GO:0033631; GO:0045669; GO:0070062; GO:0070374; GO:0071356
GN010327	GN010327.1	B3EWY9	33.0	303	815	1594	3.31e-23	110	MLP_ACRMI	Mucin-like protein	Acropora millepora (Staghorn coral) (Heteropora millepora)	cell-matrix adhesion [GO:0007160]	calcium ion binding [GO:0005509]	membrane [GO:0016020]	GO:0005509; GO:0007160; GO:0016020
GN010328	GN010328.1	Q9UBV8	50.9	175	217	284	4.62e-57	185	PEF1_HUMAN	Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1)	Homo sapiens (Human)	COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	COPII vesicle coat [GO:0030127]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0003723; GO:0005509; GO:0005737; GO:0005783; GO:0005829; GO:0006888; GO:0014029; GO:0014032; GO:0016020; GO:0030127; GO:0031463; GO:0042802; GO:0046982; GO:0046983; GO:0048208; GO:0048306; GO:0051592; GO:0070062; GO:1902527; GO:1990756
GN010329	GN010329.1	O15118	48.1	949	972	1278	1.39e-278	815	NPC1_HUMAN	NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein)	Homo sapiens (Human)	autophagy [GO:0006914]; bile acid metabolic process [GO:0008206]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol transport [GO:0030301]; establishment of protein localization to membrane [GO:0090150]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; intestinal cholesterol absorption [GO:0030299]; intracellular cholesterol transport [GO:0032367]; intracellular lipid transport [GO:0032365]; lysosomal transport [GO:0007041]; lysosome to ER cholesterol transport [GO:0090120]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of TORC1 signaling [GO:1904262]; response to cadmium ion [GO:0046686]; sterol transport [GO:0015918]; symbiont entry into host cell [GO:0046718]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	cytoplasmic side of lysosomal membrane [GO:0098574]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0004888; GO:0005576; GO:0005635; GO:0005764; GO:0005765; GO:0005783; GO:0005794; GO:0005886; GO:0006914; GO:0007041; GO:0008206; GO:0009101; GO:0010467; GO:0015485; GO:0015918; GO:0016020; GO:0030299; GO:0030301; GO:0031579; GO:0031902; GO:0032365; GO:0032367; GO:0033344; GO:0038023; GO:0042632; GO:0045121; GO:0046686; GO:0046718; GO:0048471; GO:0070062; GO:0090120; GO:0090150; GO:0098574; GO:0120020; GO:1904036; GO:1904262
GN010330	GN010330.1	O15118	66.7	204	235	1278	3.49e-78	258	NPC1_HUMAN	NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein)	Homo sapiens (Human)	autophagy [GO:0006914]; bile acid metabolic process [GO:0008206]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol transport [GO:0030301]; establishment of protein localization to membrane [GO:0090150]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; intestinal cholesterol absorption [GO:0030299]; intracellular cholesterol transport [GO:0032367]; intracellular lipid transport [GO:0032365]; lysosomal transport [GO:0007041]; lysosome to ER cholesterol transport [GO:0090120]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of TORC1 signaling [GO:1904262]; response to cadmium ion [GO:0046686]; sterol transport [GO:0015918]; symbiont entry into host cell [GO:0046718]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	cytoplasmic side of lysosomal membrane [GO:0098574]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0004888; GO:0005576; GO:0005635; GO:0005764; GO:0005765; GO:0005783; GO:0005794; GO:0005886; GO:0006914; GO:0007041; GO:0008206; GO:0009101; GO:0010467; GO:0015485; GO:0015918; GO:0016020; GO:0030299; GO:0030301; GO:0031579; GO:0031902; GO:0032365; GO:0032367; GO:0033344; GO:0038023; GO:0042632; GO:0045121; GO:0046686; GO:0046718; GO:0048471; GO:0070062; GO:0090120; GO:0090150; GO:0098574; GO:0120020; GO:1904036; GO:1904262
GN010333	GN010333.1	P16320	22.1	407	738	1056	9.29e-11	69.3	NOF_DROME	120.7 kDa protein in NOF-FB transposable element	Drosophila melanogaster (Fruit fly)			nucleus [GO:0005634]	GO:0005634
GN010334	GN010334.1	O35604	48.4	1194	1190	1277	0.0	1102	NPC1_MOUSE	NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein)	Mus musculus (Mouse)	adult walking behavior [GO:0007628]; autophagy [GO:0006914]; bile acid metabolic process [GO:0008206]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to steroid hormone stimulus [GO:0071383]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol storage [GO:0010878]; cholesterol transport [GO:0030301]; cyclodextrin metabolic process [GO:2000900]; endocytosis [GO:0006897]; establishment of protein localization to membrane [GO:0090150]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; intestinal cholesterol absorption [GO:0030299]; intracellular cholesterol transport [GO:0032367]; intracellular lipid transport [GO:0032365]; liver development [GO:0001889]; lysosomal transport [GO:0007041]; lysosome to ER cholesterol transport [GO:0090120]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TORC1 signaling [GO:1904262]; neurogenesis [GO:0022008]; programmed cell death [GO:0012501]; response to cadmium ion [GO:0046686]; response to xenobiotic stimulus [GO:0009410]; sterol metabolic process [GO:0016125]; sterol transport [GO:0015918]; symbiont entry into host cell [GO:0046718]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]	cytoplasmic side of lysosomal membrane [GO:0098574]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GO:0001889; GO:0005576; GO:0005635; GO:0005764; GO:0005765; GO:0005768; GO:0005783; GO:0005794; GO:0005886; GO:0006897; GO:0006914; GO:0007041; GO:0007628; GO:0008206; GO:0009101; GO:0009410; GO:0010467; GO:0010878; GO:0012501; GO:0015485; GO:0015918; GO:0016020; GO:0016125; GO:0016242; GO:0022008; GO:0030299; GO:0030301; GO:0031579; GO:0031902; GO:0031982; GO:0032365; GO:0032367; GO:0033344; GO:0042632; GO:0045121; GO:0046686; GO:0046718; GO:0048471; GO:0071383; GO:0071404; GO:0090120; GO:0090150; GO:0098574; GO:0120020; GO:1904036; GO:1904262; GO:2000900
GN010335	GN010335.1	O01369	40.9	93	358	130	5.05e-15	74.3	QCR7_FASHE	Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (Ubiquinol-cytochrome c reductase complex 14 kDa protein)	Fasciola hepatica (Liver fluke)	mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]		mitochondrial inner membrane [GO:0005743]; respiratory chain complex III [GO:0045275]	GO:0005743; GO:0006122; GO:0045275
GN010338	GN010338.1	Q5MNV8	36.8	446	445	452	6.52e-83	265	FBX47_HUMAN	F-box only protein 47	Homo sapiens (Human)	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]		SCF ubiquitin ligase complex [GO:0019005]	GO:0019005; GO:0031146
GN010339	GN010339.1	G5ED84	25.0	172	674	690	3.08e-09	63.9	KLHL8_CAEEL	Kelch-like protein 8	Caenorhabditis elegans	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]	GO:0005737; GO:0006511; GO:0014069; GO:0016567; GO:0031463; GO:0043005; GO:0043025; GO:0043161; GO:1990756
GN010340	GN010340.1	P19217	35.1	282	297	295	1.46e-47	164	ST1E1_BOVIN	Sulfotransferase 1E1 (ST1E1) (EC 2.8.2.4) (Estrogen sulfotransferase) (Sulfotransferase, estrogen-preferring)	Bos taurus (Bovine)	estrogen metabolic process [GO:0008210]; sulfation [GO:0051923]	aryl sulfotransferase activity [GO:0004062]; estrone sulfotransferase activity [GO:0004304]; steroid sulfotransferase activity [GO:0050294]	cytosol [GO:0005829]	GO:0004062; GO:0004304; GO:0005829; GO:0008210; GO:0050294; GO:0051923
GN010341	GN010341.1	Q95JD5	35.1	285	301	296	3.99e-45	157	ST1B1_CANLF	Sulfotransferase 1B1 (ST1B1) (cSULT1B1) (EC 2.8.2.1) (Sulfotransferase family cytosolic 1B member 1)	Canis lupus familiaris (Dog) (Canis familiaris)	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	aryl sulfotransferase activity [GO:0004062]	cytoplasm [GO:0005737]	GO:0004062; GO:0005737; GO:0006068; GO:0006805; GO:0009812; GO:0030855; GO:0042403; GO:0050427; GO:0051923
GN010342	GN010342.1	Q95JD5	32.9	231	363	296	6.98e-27	111	ST1B1_CANLF	Sulfotransferase 1B1 (ST1B1) (cSULT1B1) (EC 2.8.2.1) (Sulfotransferase family cytosolic 1B member 1)	Canis lupus familiaris (Dog) (Canis familiaris)	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	aryl sulfotransferase activity [GO:0004062]	cytoplasm [GO:0005737]	GO:0004062; GO:0005737; GO:0006068; GO:0006805; GO:0009812; GO:0030855; GO:0042403; GO:0050427; GO:0051923
GN010343	GN010343.1	P50729	33.3	108	208	496	5.71e-09	58.5	RECS_BACSU	Probable ATP-dependent DNA helicase RecS (EC 5.6.2.4) (Probable DNA 3'-5' helicase RecS) (Recombination protein S)	Bacillus subtilis (strain 168)	DNA recombination [GO:0006310]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]	GO:0003676; GO:0005524; GO:0005694; GO:0005737; GO:0006310; GO:0016887; GO:0030894; GO:0043138; GO:0043590
GN010344	GN010344.1	Q95JD5	33.6	295	301	296	7.19e-42	149	ST1B1_CANLF	Sulfotransferase 1B1 (ST1B1) (cSULT1B1) (EC 2.8.2.1) (Sulfotransferase family cytosolic 1B member 1)	Canis lupus familiaris (Dog) (Canis familiaris)	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	aryl sulfotransferase activity [GO:0004062]	cytoplasm [GO:0005737]	GO:0004062; GO:0005737; GO:0006068; GO:0006805; GO:0009812; GO:0030855; GO:0042403; GO:0050427; GO:0051923
GN010347	GN010347.1	Q9VZW5	27.7	307	355	549	2.25e-18	89.7	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN010350	GN010350.1	Q6R653	35.6	450	655	518	2.47e-75	253	UN5CL_MOUSE	UNC5C-like protein (Protein unc-5 homolog C-like) (ZU5 and death domain-containing protein)	Mus musculus (Mouse)	positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330]	netrin receptor activity [GO:0005042]; peptidase activity [GO:0008233]	centrosome [GO:0005813]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005042; GO:0005813; GO:0005829; GO:0005886; GO:0008233; GO:0016020; GO:0043123; GO:0046330
GN010355	GN010355.1	O75901	29.7	354	545	435	1.84e-22	103	RASF9_HUMAN	Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor)	Homo sapiens (Human)	endosomal transport [GO:0016197]; protein targeting [GO:0006605]; signal transduction [GO:0007165]		cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; recycling endosome [GO:0055037]; trans-Golgi network transport vesicle membrane [GO:0012510]	GO:0005768; GO:0005829; GO:0006605; GO:0007165; GO:0012510; GO:0016197; GO:0055037; GO:0070062
GN010357	GN010357.1	P0CI75	26.6	169	459	325	7.38e-14	75.9	BIRA_BACSU	Bifunctional ligase/repressor BirA (Biotin--[acetyl-CoA-carboxylase] ligase) (EC 6.3.4.15) (Biotin--protein ligase) (Biotin-[acetyl-CoA carboxylase] synthetase)	Bacillus subtilis (strain 168)	protein lipoylation [GO:0009249]; regulation of DNA-templated transcription [GO:0006355]	ATP binding [GO:0005524]; biotin--[biotin carboxyl-carrier protein] ligase activity [GO:0004077]; DNA binding [GO:0003677]; transferase activity [GO:0016740]		GO:0003677; GO:0004077; GO:0005524; GO:0006355; GO:0009249; GO:0016740
GN010358	GN010358.1	F4I4W2	23.6	203	463	329	1.21e-09	63.2	HCS2_ARATH	Biotin--protein ligase 2 (EC 6.3.4.-) (Holocarboxylase synthetase 2)	Arabidopsis thaliana (Mouse-ear cress)			chloroplast [GO:0009507]; cytoplasm [GO:0005737]	GO:0005737; GO:0009507
GN010359	GN010359.1	Q6NRW0	46.9	81	294	860	9.53e-12	68.9	MTBP_XENLA	Mdm2-binding protein	Xenopus laevis (African clawed frog)	protein localization to kinetochore [GO:0034501]; regulation of protein ubiquitination [GO:0031396]; traversing start control point of mitotic cell cycle [GO:0007089]		kinetochore [GO:0000776]	GO:0000776; GO:0007089; GO:0031396; GO:0034501
GN010362	GN010362.1	H2A0L3	33.2	325	338	359	7.50e-57	191	ELDP2_PINMG	EGF-like domain containing protein 2	Margaritifera margaritifera (Freshwater pearl mussel)			extracellular region [GO:0005576]	GO:0005576
GN010363	GN010363.1	P86954	38.0	353	353	357	6.80e-69	223	ELDP2_PINMA	EGF-like domain-containing protein 2	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]	GO:0005102; GO:0005576; GO:0009986
GN010364	GN010364.1	Q9H3Q3	29.9	278	395	398	1.71e-26	112	G3ST2_HUMAN	Galactose-3-O-sulfotransferase 2 (Gal3ST-2) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 2) (Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2) (Glycoprotein beta-Gal 3'-sulfotransferase 2)	Homo sapiens (Human)	glycolipid biosynthetic process [GO:0009247]; glycoprotein biosynthetic process [GO:0009101]	galactose 3-O-sulfotransferase activity [GO:0050694]; galactosylceramide sulfotransferase activity [GO:0001733]	Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]	GO:0001733; GO:0009101; GO:0009247; GO:0016020; GO:0032580; GO:0050694
GN010368	GN010368.1	O86938	32.9	380	442	397	6.65e-55	190	PPD_STRVT	Phosphonopyruvate decarboxylase (EC 4.1.1.82)	Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494)	organic phosphonate biosynthetic process [GO:0032923]	magnesium ion binding [GO:0000287]; phosphonopyruvate decarboxylase activity [GO:0033980]; thiamine pyrophosphate binding [GO:0030976]		GO:0000287; GO:0030976; GO:0032923; GO:0033980
GN010369	GN010369.1	Q9D3W1	36.1	341	341	341	1.11e-62	206	RSP14_MOUSE	Radial spoke head 14 homolog (Rhabdoid tumor deletion region protein 1)	Mus musculus (Mouse)	cilium movement [GO:0003341]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; mating [GO:0007618]		9+2 motile cilium [GO:0097729]; cilium [GO:0005929]; extracellular region [GO:0005576]; radial spoke [GO:0001534]; sperm flagellum [GO:0036126]	GO:0001534; GO:0003341; GO:0003351; GO:0005576; GO:0005929; GO:0007618; GO:0030317; GO:0036126; GO:0097729
GN010371	GN010371.1	Q2YDS5	55.2	96	358	249	2.37e-28	114	SCNM1_DANRE	Sodium channel modifier 1	Danio rerio (Zebrafish) (Brachydanio rerio)	alternative mRNA splicing, via spliceosome [GO:0000380]; RNA splicing [GO:0008380]		nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0000380; GO:0005634; GO:0008380; GO:0016607
GN010372	GN010372.1	Q9TRY0	50.5	404	461	459	1.22e-133	396	FKBP4_BOVIN	Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (FK506-binding protein 4) (FKBP-4) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]	Bos taurus (Bovine)	negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of neuron projection development [GO:0010977]; protein folding [GO:0006457]	peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	axonal growth cone [GO:0044295]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0003755; GO:0005634; GO:0005739; GO:0005829; GO:0005856; GO:0006457; GO:0010977; GO:0031111; GO:0044295
GN010379	GN010379.1	Q9U943	25.7	1656	5548	3380	4.92e-110	401	APLP_LOCMI	Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)]	Locusta migratoria (Migratory locust)	lipid transport [GO:0006869]	lipid carrier activity [GO:0005319]	extracellular region [GO:0005576]	GO:0005319; GO:0005576; GO:0006869
GN010380	GN010380.1	Q9U943	25.8	1656	5435	3380	2.13e-110	402	APLP_LOCMI	Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)]	Locusta migratoria (Migratory locust)	lipid transport [GO:0006869]	lipid carrier activity [GO:0005319]	extracellular region [GO:0005576]	GO:0005319; GO:0005576; GO:0006869
GN010381	GN010381.1	Q23045	81.8	99	625	470	5.13e-49	181	EGL13_CAEEL	Transcription factor egl-13 (Protein egg laying defective 13)	Caenorhabditis elegans	anatomical structure morphogenesis [GO:0009653]; asymmetric neuroblast division [GO:0055059]; cell fate commitment [GO:0045165]; cell fate specification [GO:0001708]; neuron fate determination [GO:0048664]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; vulval development [GO:0040025]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001708; GO:0005634; GO:0006355; GO:0006357; GO:0009653; GO:0040025; GO:0045165; GO:0048664; GO:0055059
GN010383	GN010383.1	Q6P877	63.6	385	391	404	3.03e-107	324	ADRM1_XENTR	Proteasomal ubiquitin receptor ADRM1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	proteasome assembly [GO:0043248]	endopeptidase activator activity [GO:0061133]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome complex [GO:0000502]	GO:0000502; GO:0005634; GO:0005737; GO:0043248; GO:0061133
GN010384	GN010384.1	Q8BYH0	39.8	201	288	263	1.45e-28	113	DRGX_MOUSE	Dorsal root ganglia homeobox protein (Dorsal root ganglion 11) (Homeobox protein DRG11) (Paired-related homeobox protein-like 1)	Mus musculus (Mouse)	axon guidance [GO:0007411]; axonogenesis [GO:0007409]; detection of chemical stimulus [GO:0009593]; detection of temperature stimulus [GO:0016048]; dorsal spinal cord development [GO:0021516]; nervous system development [GO:0007399]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of mechanical stimulus [GO:0050954]; trigeminal nerve development [GO:0021559]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0001764; GO:0003677; GO:0003700; GO:0005634; GO:0006357; GO:0007399; GO:0007409; GO:0007411; GO:0009593; GO:0016048; GO:0021516; GO:0021559; GO:0030182; GO:0048666; GO:0050954; GO:1990837
GN010389	GN010389.1	Q9VE51	38.9	72	103	684	1.21e-09	57.0	CPSF3_DROME	Cleavage and polyadenylation specificity factor 73 (EC 3.1.27.-)	Drosophila melanogaster (Fruit fly)	co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; nuclear histone mRNA catabolic process [GO:0071045]	5'-3' RNA exonuclease activity [GO:0004534]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]	GO:0003723; GO:0004521; GO:0004534; GO:0005847; GO:0005849; GO:0006398; GO:0071045; GO:0180010
GN010390	GN010390.1	P79101	78.8	565	574	684	0.0	926	CPSF3_BOVIN	Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73)	Bos taurus (Bovine)	mRNA 3'-end processing [GO:0031124]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	5'-3' RNA exonuclease activity [GO:0004534]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA endonuclease activity [GO:0004521]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleus [GO:0005634]	GO:0003723; GO:0004521; GO:0004534; GO:0005634; GO:0005847; GO:0006398; GO:0031124; GO:0046872; GO:1900087
GN010391	GN010391.1	Q2KI15	45.5	323	421	380	1.39e-87	274	RF1ML_BOVIN	Peptide chain release factor 1-like, mitochondrial (Mitochondrial translational release factor 1-like)	Bos taurus (Bovine)	mitochondrial translational termination [GO:0070126]	translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]	mitochondrion [GO:0005739]	GO:0003747; GO:0005739; GO:0016149; GO:0070126
GN010395	GN010395.1	P86854	31.6	152	176	156	4.75e-24	95.1	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN010396	GN010396.1	A5HNF6	31.2	141	179	299	1.27e-13	70.5	MYD88_CHICK	Myeloid differentiation primary response protein MyD88	Gallus gallus (Chicken)	defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]	TIR domain binding [GO:0070976]; Toll-like receptor binding [GO:0035325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0002224; GO:0002755; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0008063; GO:0034142; GO:0035325; GO:0043123; GO:0045087; GO:0050830; GO:0070976; GO:1901224
GN010397	GN010397.1	B3A0P5	40.6	217	496	419	2.28e-41	156	GEPRP_LOTGI	Glycine, glutamate and proline-rich protein	Lottia gigantea (Giant owl limpet)	peptidoglycan catabolic process [GO:0009253]	lysozyme activity [GO:0003796]	extracellular region [GO:0005576]	GO:0003796; GO:0005576; GO:0009253
GN010398	GN010398.1	P50411	39.5	167	187	205	6.52e-22	91.3	IPP2_RAT	Protein phosphatase inhibitor 2 (IPP-2)	Rattus norvegicus (Rat)	intracellular signal transduction [GO:0035556]; regulation of signal transduction [GO:0009966]	molecular function inhibitor activity [GO:0140678]; protein domain specific binding [GO:0019904]; protein phosphatase inhibitor activity [GO:0004864]	dendritic spine [GO:0043197]; growth cone [GO:0030426]	GO:0004864; GO:0009966; GO:0019904; GO:0030426; GO:0035556; GO:0043197; GO:0140678
GN010399	GN010399.1	Q5R5X9	27.6	644	677	804	6.67e-47	181	SMYD4_PONAB	Protein-lysine N-methyltransferase SMYD4 (EC 2.1.1.-) (SET and MYND domain-containing protein 4)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	heart development [GO:0007507]	histone deacetylase binding [GO:0042826]; protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0007507; GO:0016279; GO:0042826
GN010400	GN010400.1	Q9SAJ7	38.1	381	459	402	1.73e-68	226	MTP9_ARATH	Metal tolerance protein 9 (AtMTP9)	Arabidopsis thaliana (Mouse-ear cress)		monoatomic cation transmembrane transporter activity [GO:0008324]	nucleus [GO:0005634]; vacuolar membrane [GO:0005774]	GO:0005634; GO:0005774; GO:0008324
GN010401	GN010401.1	Q01459	26.0	350	452	385	8.59e-19	91.3	DIAC_HUMAN	Di-N-acetylchitobiase (EC 3.2.1.-)	Homo sapiens (Human)	carbohydrate catabolic process [GO:0016052]; chitin catabolic process [GO:0006032]; oligosaccharide catabolic process [GO:0009313]	chitin binding [GO:0008061]; chitinase activity [GO:0004568]; hydrolase activity, acting on glycosyl bonds [GO:0016798]	extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0004568; GO:0005576; GO:0005764; GO:0006032; GO:0008061; GO:0009313; GO:0016052; GO:0016798
GN010402	GN010402.1	Q9Y6J0	31.8	2123	2661	2220	1.08e-254	827	CABIN_HUMAN	Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN)	Homo sapiens (Human)	cell surface receptor signaling pathway [GO:0007166]; chromatin organization [GO:0006325]; DNA replication-dependent chromatin assembly [GO:0006335]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome assembly [GO:0006334]; regulation of chromatin organization [GO:1902275]	protein phosphatase inhibitor activity [GO:0004864]; transcription corepressor activity [GO:0003714]	HIR complex [GO:0000417]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000417; GO:0003714; GO:0004864; GO:0005634; GO:0005654; GO:0006325; GO:0006334; GO:0006335; GO:0007166; GO:1902275
GN010403	GN010403.1	Q8BGB5	52.6	78	1320	128	8.54e-23	98.6	LIMD2_MOUSE	LIM domain-containing protein 2	Mus musculus (Mouse)			actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0015629
GN010404	GN010404.1	P83876	85.9	142	142	142	3.71e-94	271	TXN4A_HUMAN	Thioredoxin-like protein 4A (DIM1 protein homolog) (Spliceosomal U5 snRNP-specific 15 kDa protein) (Thioredoxin-like U5 snRNP protein U5-15kD)	Homo sapiens (Human)	mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]	GO:0000245; GO:0000375; GO:0000387; GO:0000398; GO:0005634; GO:0005654; GO:0005681; GO:0005682; GO:0046540; GO:0071005; GO:0071011
GN010406	GN010406.1	A8QMS7	38.1	134	185	288	2.14e-19	86.3	MYD88_TAKRU	Myeloid differentiation primary response protein MyD88	Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)	defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]	TIR domain binding [GO:0070976]; Toll-like receptor binding [GO:0035325]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0002755; GO:0005737; GO:0005886; GO:0008063; GO:0034142; GO:0035325; GO:0043123; GO:0045087; GO:0050830; GO:0070976
GN010407	GN010407.1	Q5VWW1	32.4	108	278	255	2.35e-09	60.1	C1QL3_HUMAN	Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0097107; GO:0098686; GO:0098978; GO:0099550; GO:0099558; GO:0099645
GN010408	GN010408.1	C8BKC7	25.7	334	662	296	1.06e-19	93.6	MYD88_SHEEP	Myeloid differentiation primary response protein MyD88	Ovis aries (Sheep)	defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 8 signaling pathway [GO:0034158]	cytokine receptor binding [GO:0005126]; TIR domain binding [GO:0070976]; Toll-like receptor binding [GO:0035325]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0002755; GO:0005126; GO:0005634; GO:0005737; GO:0005886; GO:0008063; GO:0032731; GO:0034142; GO:0034158; GO:0035325; GO:0043123; GO:0045087; GO:0050830; GO:0051607; GO:0070976; GO:1900227
GN010410	GN010410.1	Q5RDB4	39.8	254	488	444	2.42e-50	181	NEMP1_PONAB	Nuclear envelope integral membrane protein 1	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	erythrocyte enucleation [GO:0043131]; erythrocyte maturation [GO:0043249]		nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]	GO:0005635; GO:0005637; GO:0043131; GO:0043249
GN010413	GN010413.1	E9Q4F2	63.8	307	535	574	5.51e-137	411	KLH18_MOUSE	Kelch-like protein 18	Mus musculus (Mouse)	positive regulation of mitotic cell cycle phase transition [GO:1901992]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]	GO:0005737; GO:0016567; GO:0031463; GO:0043161; GO:1901992; GO:1990756
GN010414	GN010414.1	Q9D4B2	26.4	720	948	624	1.23e-56	210	ODAD4_MOUSE	Outer dynein arm-docking complex subunit 4 (Tetratricopeptide repeat protein 25) (TPR repeat protein 25)	Mus musculus (Mouse)	brain development [GO:0007420]; cerebrospinal fluid circulation [GO:0090660]; cilium movement [GO:0003341]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; heart development [GO:0007507]; lung development [GO:0030324]; mucociliary clearance [GO:0120197]; outer dynein arm assembly [GO:0036158]; protein localization to motile cilium [GO:0120229]		9+0 motile cilium [GO:0097728]; 9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; outer dynein arm docking complex [GO:0120228]	GO:0003341; GO:0005576; GO:0005737; GO:0005930; GO:0007420; GO:0007507; GO:0030324; GO:0036158; GO:0060287; GO:0090660; GO:0097728; GO:0097729; GO:0120197; GO:0120228; GO:0120229
GN010415	GN010415.1	F6RIX4	62.0	640	1061	1117	1.40e-267	785	MCM9_XENTR	DNA helicase MCM9 (EC 5.6.2.4) (DNA 3'-5' helicase MCM9) (Minichromosome maintenance 9)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; regulation of DNA-templated DNA replication initiation [GO:0030174]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	MCM complex [GO:0042555]; MCM8-MCM9 complex [GO:0097362]; nucleus [GO:0005634]	GO:0000724; GO:0003697; GO:0005524; GO:0005634; GO:0006974; GO:0016887; GO:0030174; GO:0042555; GO:0043138; GO:0097362
GN010416	GN010416.1	Q90593	73.9	606	645	652	0.0	886	BIP_CHICK	Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)	Gallus gallus (Chicken)	cellular response to glucose starvation [GO:0042149]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum structural organization [GO:0021589]; endoplasmic reticulum unfolded protein response [GO:0030968]; IRE1-mediated unfolded protein response [GO:0036498]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of protein-containing complex assembly [GO:0031333]; positive regulation of cell migration [GO:0030335]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein ubiquitination [GO:0031398]; post-translational protein targeting to membrane, translocation [GO:0031204]; protein refolding [GO:0042026]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; heat shock protein binding [GO:0031072]; misfolded protein binding [GO:0051787]; protein domain specific binding [GO:0019904]; protein folding chaperone [GO:0044183]; protein sequestering activity [GO:0140311]; protein serine/threonine kinase inhibitor activity [GO:0030291]; ribosome binding [GO:0043022]; ubiquitin protein ligase binding [GO:0031625]	cell surface [GO:0009986]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0005524; GO:0005737; GO:0005739; GO:0005788; GO:0005789; GO:0005793; GO:0005829; GO:0005886; GO:0008180; GO:0009986; GO:0016020; GO:0016887; GO:0019904; GO:0021589; GO:0021680; GO:0030291; GO:0030335; GO:0030496; GO:0030968; GO:0031072; GO:0031204; GO:0031333; GO:0031398; GO:0031625; GO:0034663; GO:0035437; GO:0036498; GO:0042026; GO:0042149; GO:0042470; GO:0043022; GO:0043066; GO:0044183; GO:0045732; GO:0051787; GO:0140311; GO:1903895; GO:1903898
GN010417	GN010417.1	Q96A58	66.1	189	211	199	3.26e-84	251	RERG_HUMAN	Ras-related and estrogen-regulated growth inhibitor (EC 3.6.5.2)	Homo sapiens (Human)	establishment or maintenance of cell polarity [GO:0007163]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; Ras protein signal transduction [GO:0007265]; response to hormone [GO:0009725]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; nuclear estrogen receptor binding [GO:0030331]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005525; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0007163; GO:0007264; GO:0007265; GO:0008285; GO:0009725; GO:0019003; GO:0030308; GO:0030331
GN010418	GN010418.1	Q3T0Y3	33.6	271	304	296	6.92e-39	141	ST1B1_BOVIN	Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase family cytosolic 1B member 1)	Bos taurus (Bovine)	sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]	aryl sulfotransferase activity [GO:0004062]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004062; GO:0005737; GO:0005829; GO:0042403; GO:0051923
GN010420	GN010420.1	Q8JG30	35.2	176	216	296	2.69e-24	100	ST1B1_CHICK	Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase family cytosolic 1B member 1)	Gallus gallus (Chicken)	sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]	aryl sulfotransferase activity [GO:0004062]	cytoplasm [GO:0005737]	GO:0004062; GO:0005737; GO:0042403; GO:0051923
GN010421	GN010421.1	P49887	36.1	169	210	296	1.74e-19	87.4	ST1E1_CAVPO	Sulfotransferase 1E1 (ST1E1) (EC 2.8.2.4) (Estrogen sulfotransferase) (ST1E3) (Sulfotransferase, estrogen-preferring)	Cavia porcellus (Guinea pig)	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; estrogen catabolic process [GO:0006711]; estrogen metabolic process [GO:0008210]; ethanol catabolic process [GO:0006068]; positive regulation of fat cell differentiation [GO:0045600]; sulfation [GO:0051923]	estrone sulfotransferase activity [GO:0004304]; flavonol 3-sulfotransferase activity [GO:0047894]; steroid sulfotransferase activity [GO:0050294]	cytosol [GO:0005829]	GO:0004304; GO:0005829; GO:0006068; GO:0006711; GO:0008210; GO:0045600; GO:0047894; GO:0050294; GO:0050427; GO:0051923
GN010423	GN010423.1	Q8BVF7	47.0	166	189	265	3.42e-44	150	APH1A_MOUSE	Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha)	Mus musculus (Mouse)	amyloid precursor protein catabolic process [GO:0042987]; amyloid precursor protein metabolic process [GO:0042982]; amyloid-beta formation [GO:0034205]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; metanephros development [GO:0001656]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; protein processing [GO:0016485]	endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]; peptidase activity [GO:0008233]; protein-macromolecule adaptor activity [GO:0030674]	early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; gamma-secretase complex [GO:0070765]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]	GO:0000139; GO:0001656; GO:0005769; GO:0005783; GO:0005789; GO:0005794; GO:0005886; GO:0006509; GO:0007219; GO:0007220; GO:0008021; GO:0008233; GO:0016020; GO:0016485; GO:0019899; GO:0030674; GO:0031293; GO:0032580; GO:0034205; GO:0042734; GO:0042982; GO:0042987; GO:0061133; GO:0070765; GO:0097060
GN010427	GN010427.1	Q5R405	58.7	1028	1070	1083	0.0	1024	SPT5H_PONAB	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	regulation of DNA-templated transcription elongation [GO:0032784]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]	mRNA binding [GO:0003729]	DSIF complex [GO:0032044]; nucleus [GO:0005634]	GO:0003729; GO:0005634; GO:0006357; GO:0006368; GO:0032044; GO:0032784
GN010430	GN010430.1	Q8CDK2	54.4	652	1585	862	6.46e-232	700	CBPC2_MOUSE	Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) (Protein deglutamylase CCP2)	Mus musculus (Mouse)	protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]	metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]	GO:0004181; GO:0005737; GO:0005814; GO:0005829; GO:0006508; GO:0008270; GO:0015630; GO:0015631; GO:0035610; GO:0036064
GN010431	GN010431.1	Q28J59	58.9	287	331	295	4.94e-120	350	F221A_XENTR	Protein FAM221A	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)				
GN010432	GN010432.1	Q1ZZH1	24.4	468	1096	879	1.97e-33	143	GRM3_MACFA	Metabotropic glutamate receptor 3 (mGluR3)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	G protein-coupled glutamate receptor signaling pathway [GO:0007216]	G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007216; GO:0008066
GN010435	GN010435.1	Q6PFM4	47.8	314	992	402	6.43e-71	244	LNPB_DANRE	Endoplasmic reticulum junction formation protein lunapark-B (ER junction formation factor lunapark)	Danio rerio (Zebrafish) (Brachydanio rerio)	endoplasmic reticulum tubular network maintenance [GO:0071788]; endoplasmic reticulum tubular network organization [GO:0071786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]	identical protein binding [GO:0042802]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endoplasmic reticulum tubular network membrane [GO:0098826]	GO:0005789; GO:0042802; GO:0071782; GO:0071786; GO:0071788; GO:0098826; GO:1903373
GN010437	GN010437.1	Q3ZBL4	45.3	278	265	299	3.20e-63	203	LZTL1_BOVIN	Leucine zipper transcription factor-like protein 1	Bos taurus (Bovine)	flagellated sperm motility [GO:0030317]; negative regulation of protein localization to ciliary membrane [GO:1903568]; negative regulation of protein localization to cilium [GO:1903565]	identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; manchette [GO:0002177]	GO:0002177; GO:0005737; GO:0005829; GO:0005929; GO:0030317; GO:0042802; GO:0044877; GO:1903565; GO:1903568
GN010438	GN010438.1	Q28I29	43.5	299	321	294	1.37e-67	216	DTWD1_XENTR	tRNA-uridine aminocarboxypropyltransferase 1 (EC 2.5.1.25) (DTW domain-containing protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	tRNA modification [GO:0006400]	tRNA-uridine aminocarboxypropyltransferase activity [GO:0016432]	nucleus [GO:0005634]	GO:0005634; GO:0006400; GO:0016432
GN010444	GN010444.1	P48643	77.4	442	445	541	3.79e-249	692	TCPE_HUMAN	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)	Homo sapiens (Human)	positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to virus [GO:0009615]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; beta-tubulin binding [GO:0048487]; G-protein beta-subunit binding [GO:0031681]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; protein folding chaperone [GO:0044183]	cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]	GO:0003730; GO:0005524; GO:0005737; GO:0005813; GO:0005829; GO:0005832; GO:0005874; GO:0006457; GO:0009615; GO:0016887; GO:0031681; GO:0032212; GO:0044183; GO:0044297; GO:0048027; GO:0048487; GO:0050821; GO:0070062; GO:0140662; GO:1904871; GO:1904874
GN010446	GN010446.1	Q7Z4L5	53.7	1294	1308	1316	0.0	1296	TT21B_HUMAN	Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) (Intraflagellar transport 139 homolog)	Homo sapiens (Human)	cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; protein localization to cilium [GO:0061512]; regulation of intraciliary retrograde transport [GO:1905799]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]	axoneme [GO:0005930]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]	GO:0003682; GO:0005929; GO:0005930; GO:0006357; GO:0030991; GO:0035721; GO:0060271; GO:0061512; GO:0097542; GO:1905799
GN010449	GN010449.1	P08621	69.8	225	364	437	1.10e-102	312	RU17_HUMAN	U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)	Homo sapiens (Human)	cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of chaperone-mediated autophagy [GO:1904715]; negative regulation of protein refolding [GO:0061084]; regulation of RNA splicing [GO:0043484]; spliceosomal snRNP assembly [GO:0000387]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U1 snRNA binding [GO:0030619]; U1 snRNP binding [GO:1990446]	lysosomal lumen [GO:0043202]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]	GO:0000387; GO:0000398; GO:0003723; GO:0003729; GO:0005634; GO:0005654; GO:0005681; GO:0005685; GO:0016607; GO:0030619; GO:0043202; GO:0043484; GO:0061084; GO:0071004; GO:0071011; GO:0071300; GO:0071356; GO:0071560; GO:1904715; GO:1990446
GN010450	GN010450.1	P08510	71.1	450	513	655	3.19e-206	590	KCNAS_DROME	Potassium voltage-gated channel protein Shaker (Protein minisleep)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; axon extension [GO:0048675]; behavioral response to ether [GO:0048150]; cellular response to dopamine [GO:1903351]; courtship behavior [GO:0007619]; detection of visible light [GO:0009584]; larval locomotory behavior [GO:0008345]; learning or memory [GO:0007611]; mating behavior, sex discrimination [GO:0048047]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; positive regulation of membrane potential [GO:0045838]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; proboscis extension reflex [GO:0007637]; protein homooligomerization [GO:0051260]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of synaptic activity [GO:0060025]; sensory perception of taste [GO:0050909]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0007611; GO:0007619; GO:0007637; GO:0008076; GO:0008345; GO:0009584; GO:0016020; GO:0022843; GO:0030431; GO:0043005; GO:0043204; GO:0045121; GO:0045187; GO:0045838; GO:0045938; GO:0048047; GO:0048150; GO:0048675; GO:0050909; GO:0051260; GO:0060025; GO:0071805; GO:1903351
GN010451	GN010451.1	Q4V7T8	57.1	217	223	219	5.58e-88	261	ROP1L_XENLA	Ropporin-1-like protein	Xenopus laevis (African clawed frog)	flagellated sperm motility [GO:0030317]; sperm capacitation [GO:0048240]		cytoplasm [GO:0005737]; motile cilium [GO:0031514]; radial spoke [GO:0001534]	GO:0001534; GO:0005737; GO:0030317; GO:0031514; GO:0048240
GN010455	GN010455.1	Q28824	51.7	331	364	1176	3.72e-107	342	MYLK_BOVIN	Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]	Bos taurus (Bovine)	positive regulation of vascular associated smooth muscle contraction [GO:1904695]; tonic smooth muscle contraction [GO:0014820]	ATP binding [GO:0005524]; myosin light chain kinase activity [GO:0004687]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; stress fiber [GO:0001725]	GO:0001725; GO:0004687; GO:0005524; GO:0005737; GO:0014820; GO:0030027; GO:0032154; GO:1904695
GN010459	GN010459.1	Q922J9	44.4	496	517	515	3.30e-175	506	FACR1_MOUSE	Fatty acyl-CoA reductase 1 (Far1) (EC 1.2.1.84)	Mus musculus (Mouse)	ether lipid biosynthetic process [GO:0008611]; glycerophospholipid biosynthetic process [GO:0046474]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025]	alcohol-forming long-chain fatty acyl-CoA reductase activity [GO:0102965]; alcohol-forming very long-chain fatty acyl-CoA reductase activity [GO:0080019]	peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0005777; GO:0005778; GO:0008611; GO:0010025; GO:0035336; GO:0046474; GO:0080019; GO:0102965
GN010477	GN010477.1	Q9ULF5	37.4	468	373	831	8.54e-67	229	S39AA_HUMAN	Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10)	Homo sapiens (Human)	epithelial to mesenchymal transition [GO:0001837]; intracellular monoatomic cation homeostasis [GO:0030003]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	monoatomic cation:bicarbonate symporter activity [GO:0140410]; protein tyrosine phosphatase activator activity [GO:0008160]; zinc ion transmembrane transporter activity [GO:0005385]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0001837; GO:0005385; GO:0005886; GO:0008160; GO:0016324; GO:0030003; GO:0071577; GO:0071578; GO:0140410
GN010479	GN010479.1	Q9MZK9	29.8	131	1385	179	8.47e-11	65.9	KLRD1_MACMU	Natural killer cells antigen CD94 (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94)	Macaca mulatta (Rhesus macaque)	natural killer cell mediated immunity [GO:0002228]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	HLA-E specific inhibitory MHC class Ib receptor activity [GO:0062082]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	GO:0001915; GO:0002223; GO:0002228; GO:0005886; GO:0009986; GO:0045953; GO:0045954; GO:0062082
GN010480	GN010480.1	Q8N695	39.5	311	391	610	6.01e-59	204	SC5A8_HUMAN	Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8)	Homo sapiens (Human)	acetate transport [GO:0006846]; chloride transport [GO:0006821]; iodide transport [GO:0015705]; lactate transport [GO:0015727]; nicotinate metabolic process [GO:1901847]; nicotinate transport [GO:2001142]; nitrate transmembrane transport [GO:0015706]; propanoate transmembrane transport [GO:0015730]; pyruvate transport [GO:0006848]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085]	iodide channel activity [GO:0160081]; lactate transmembrane transporter activity [GO:0015129]; monocarboxylate:sodium symporter activity [GO:0140161]; monocarboxylic acid transmembrane transporter activity [GO:0008028]; nicotinate transmembrane transporter activity [GO:0090416]; organic acid:sodium symporter activity [GO:0005343]; propionate transmembrane transporter activity [GO:0015552]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; GINS complex [GO:0000811]; plasma membrane [GO:0005886]	GO:0000811; GO:0005343; GO:0005886; GO:0006814; GO:0006821; GO:0006846; GO:0006848; GO:0008028; GO:0015129; GO:0015552; GO:0015705; GO:0015706; GO:0015727; GO:0015730; GO:0016324; GO:0055085; GO:0070062; GO:0090416; GO:0140161; GO:0160081; GO:1901847; GO:2001142
GN010482	GN010482.1	P78563	50.5	91	261	741	6.02e-17	83.6	RED1_HUMAN	Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase)	Homo sapiens (Human)	adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; positive regulation of viral genome replication [GO:0045070]; regulation of cell cycle [GO:0051726]; RNA processing [GO:0006396]	adenosine deaminase activity [GO:0004000]; double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0003725; GO:0003726; GO:0003729; GO:0004000; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006382; GO:0006396; GO:0006397; GO:0008285; GO:0016553; GO:0016556; GO:0030336; GO:0042802; GO:0044387; GO:0045070; GO:0051726
GN010483	GN010483.1	Q92576	40.0	460	2917	2039	2.01e-80	301	PHF3_HUMAN	PHD finger protein 3	Homo sapiens (Human)	DNA-templated transcription [GO:0006351]			GO:0006351
GN010487	GN010487.1	P12311	26.5	340	342	337	3.66e-18	87.4	ADH1_GEOSE	Alcohol dehydrogenase (EC 1.1.1.1) (ADH-T)	Geobacillus stearothermophilus (Bacillus stearothermophilus)		alcohol dehydrogenase (NAD+) activity [GO:0004022]; zinc ion binding [GO:0008270]		GO:0004022; GO:0008270
GN010491	GN010491.1	P07439	31.4	156	166	162	6.12e-20	84.3	LEC3_MEGRO	Lectin BRA-3	Megabalanus rosa (Acorn barnacle)				
GN010492	GN010492.1	Q17NZ6	37.0	92	154	160	8.22e-16	73.2	GCTL1_AEDAE	C-type lectin mosGCTL-1 (Mosquito galactose-specific binding C-type lectin) (mosGCTL-1)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)			extracellular region [GO:0005576]	GO:0005576
GN010493	GN010493.1	Q17NZ6	37.0	92	154	160	8.22e-16	73.2	GCTL1_AEDAE	C-type lectin mosGCTL-1 (Mosquito galactose-specific binding C-type lectin) (mosGCTL-1)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)			extracellular region [GO:0005576]	GO:0005576
GN010495	GN010495.1	B7Q2M2	69.3	101	152	150	2.86e-42	140	RU1C_IXOSC	U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C)	Ixodes scapularis (Black-legged tick) (Deer tick)	mRNA 5'-splice site recognition [GO:0000395]; spliceosomal snRNP assembly [GO:0000387]	mRNA binding [GO:0003729]; pre-mRNA 5'-splice site binding [GO:0030627]; U1 snRNA binding [GO:0030619]; zinc ion binding [GO:0008270]	commitment complex [GO:0000243]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]	GO:0000243; GO:0000387; GO:0000395; GO:0003729; GO:0005685; GO:0008270; GO:0030619; GO:0030627; GO:0071004
GN010498	GN010498.1	Q8C8H8	25.2	536	775	661	7.09e-41	163	KY_MOUSE	Kyphoscoliosis peptidase (EC 3.4.-.-)	Mus musculus (Mouse)	muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]	GO:0005737; GO:0005856; GO:0007517; GO:0007528; GO:0030018
GN010499	GN010499.1	Q8C8H8	24.9	493	835	661	6.32e-38	154	KY_MOUSE	Kyphoscoliosis peptidase (EC 3.4.-.-)	Mus musculus (Mouse)	muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]	GO:0005737; GO:0005856; GO:0007517; GO:0007528; GO:0030018
GN010501	GN010501.1	Q91XL9	40.2	428	456	950	2.22e-64	226	OSBL1_MOUSE	Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1)	Mus musculus (Mouse)	cholesterol homeostasis [GO:0042632]; lysosome to ER cholesterol transport [GO:0090120]	cholesterol binding [GO:0015485]; sterol sensor activity [GO:0032935]	cytosol [GO:0005829]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; endosome [GO:0005768]; late endosome [GO:0005770]; organelle membrane contact site [GO:0044232]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]	GO:0005768; GO:0005770; GO:0005829; GO:0005886; GO:0015485; GO:0032935; GO:0042632; GO:0044232; GO:0090120; GO:0097038; GO:0140284
GN010504	GN010504.1	Q9BXW6	54.5	396	424	950	7.30e-147	444	OSBL1_HUMAN	Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1)	Homo sapiens (Human)	bile acid biosynthetic process [GO:0006699]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; lysosome to ER cholesterol transport [GO:0090120]; vesicle-mediated transport [GO:0016192]	cholesterol binding [GO:0015485]; phospholipid binding [GO:0005543]; sterol sensor activity [GO:0032935]; sterol transfer activity [GO:0120015]	cytosol [GO:0005829]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; organelle membrane contact site [GO:0044232]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]	GO:0005543; GO:0005768; GO:0005770; GO:0005829; GO:0005886; GO:0006699; GO:0008203; GO:0015485; GO:0016192; GO:0032935; GO:0042632; GO:0044232; GO:0070062; GO:0090120; GO:0097038; GO:0120015; GO:0140284
GN010505	GN010505.1	Q8NEP7	31.0	310	329	349	3.67e-32	125	KLDC9_HUMAN	Kelch domain-containing protein 9 (Kelch/ankyrin repeat-containing cyclin A1-interacting protein)	Homo sapiens (Human)		cyclin binding [GO:0030332]		GO:0030332
GN010509	GN010509.1	Q7ZUB3	45.9	207	215	212	4.49e-51	167	TSN31_DANRE	Tetraspanin-31 (Tspan-31) (Sarcoma-amplified sequence homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)			membrane [GO:0016020]	GO:0016020
GN010511	GN010511.1	Q9UJT9	58.0	193	598	491	9.38e-43	163	FBXL7_HUMAN	F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7)	Homo sapiens (Human)	G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]		centrosome [GO:0005813]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]	GO:0000086; GO:0000151; GO:0000209; GO:0000278; GO:0005813; GO:0005829; GO:0006511; GO:0016567; GO:0019005; GO:0031146; GO:0042981
GN010514	GN010514.1	A4IGP0	57.7	196	195	197	1.28e-81	243	HIKES_XENTR	Protein Hikeshi	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cellular response to heat [GO:0034605]; protein import into nucleus [GO:0006606]; protein transport [GO:0015031]	Hsp70 protein binding [GO:0030544]; nuclear import signal receptor activity [GO:0061608]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0006606; GO:0015031; GO:0030544; GO:0034605; GO:0061608
GN010518	GN010518.1	Q0UM32	50.5	97	124	326	2.31e-25	100	ESF2_PHANO	Pre-rRNA-processing protein ESF2 (18S rRNA factor 2)	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; small-subunit processome assembly [GO:0034462]	RNA binding [GO:0003723]	nucleolus [GO:0005730]	GO:0000447; GO:0000472; GO:0000480; GO:0003723; GO:0005730; GO:0034462
GN010519	GN010519.1	P56470	35.2	330	335	323	5.99e-59	195	LEG4_HUMAN	Galectin-4 (Gal-4) (Antigen NY-CO-27) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4)	Homo sapiens (Human)	cell adhesion [GO:0007155]	carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936]	cytosol [GO:0005829]; extracellular matrix [GO:0031012]; plasma membrane [GO:0005886]	GO:0005829; GO:0005886; GO:0007155; GO:0016936; GO:0030246; GO:0031012
GN010520	GN010520.1	Q08CX1	34.5	698	754	722	4.45e-90	301	RASEF_XENTR	Ras and EF-hand domain-containing protein (EC 3.6.5.2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	zymogen granule exocytosis [GO:0070625]	calcium ion binding [GO:0005509]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endolysosome [GO:0036019]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]	GO:0003924; GO:0003925; GO:0005509; GO:0005525; GO:0005737; GO:0005764; GO:0005769; GO:0005770; GO:0005794; GO:0005829; GO:0019003; GO:0036019; GO:0048471; GO:0070625
GN010523	GN010523.1	P43143	26.7	285	460	493	1.32e-19	94.7	ACHA6_RAT	Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Rat)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0014059; GO:0022848; GO:0030594; GO:0032991; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN010529	GN010529.1	Q3SZ85	56.8	118	119	140	4.26e-43	140	PTRD1_BOVIN	Putative peptidyl-tRNA hydrolase PTRHD1 (EC 3.1.1.29) (Peptidyl-tRNA hydrolase domain-containing protein 1)	Bos taurus (Bovine)		peptidyl-tRNA hydrolase activity [GO:0004045]		GO:0004045
GN010530	GN010530.1	Q8CB77	41.1	214	859	773	3.62e-40	162	ELOA1_MOUSE	Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3)	Mus musculus (Mouse)	regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]		elongin complex [GO:0070449]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; transcription elongation factor complex [GO:0008023]	GO:0005634; GO:0006357; GO:0006367; GO:0006368; GO:0008023; GO:0016607; GO:0070449; GO:0090734
GN010531	GN010531.1	A0A7M7GAR4	38.3	193	243	452	1.39e-32	126	FUTA_APIME	Core alpha-(1,3)-fucosyltransferase (EC 2.4.1.214) (Fucosyltransferase A) (AmFucTA) (Glycoprotein 3-alpha-L-fucosyltransferase FucTA)	Apis mellifera (Honeybee)	N-glycan processing [GO:0006491]	glycoprotein 3-alpha-L-fucosyltransferase activity [GO:0018392]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0018392; GO:0032580
GN010533	GN010533.1	P52729	65.9	132	210	265	3.11e-51	169	HME2A_XENLA	Homeobox protein engrailed-2-A (En-2A) (Homeobox protein en-2-A) (En2 1.4)	Xenopus laevis (African clawed frog)	neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0030182
GN010534	GN010534.1	P31533	50.2	223	229	261	1.31e-54	178	HME2B_DANRE	Homeobox protein engrailed-2b (Homeobox protein en-2b) (Zf-En-1)	Danio rerio (Zebrafish) (Brachydanio rerio)	anterior/posterior pattern specification [GO:0009952]; cell fate specification [GO:0001708]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001708; GO:0005634; GO:0006357; GO:0009952; GO:0030182; GO:0030901; GO:0030917
GN010535	GN010535.1	Q14549	73.9	119	337	363	1.50e-43	156	GBX1_HUMAN	Homeobox protein GBX-1 (Gastrulation and brain-specific homeobox protein 1)	Homo sapiens (Human)	regulation of nervous system development [GO:0051960]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0051960
GN010536	GN010536.1	Q86Z23	35.5	110	210	238	3.02e-10	61.2	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN010537	GN010537.1	Q86Z23	37.3	110	417	238	3.21e-10	63.5	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN010538	GN010538.1	Q9VN14	31.3	1263	1243	1390	6.57e-180	571	CONT_DROME	Contactin	Drosophila melanogaster (Fruit fly)	axon ensheathment [GO:0008366]; axon guidance [GO:0007411]; cell adhesion involved in heart morphogenesis [GO:0061343]; dendrite self-avoidance [GO:0070593]; establishment of glial blood-brain barrier [GO:0060857]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; homophilic cell-cell adhesion [GO:0007156]; nerve maturation [GO:0021682]; septate junction assembly [GO:0019991]	cell-cell adhesion mediator activity [GO:0098632]	axon [GO:0030424]; plasma membrane [GO:0005886]; septate junction [GO:0005918]	GO:0005886; GO:0005918; GO:0007156; GO:0007411; GO:0008366; GO:0019991; GO:0021682; GO:0030424; GO:0045197; GO:0060857; GO:0061343; GO:0070593; GO:0098632
GN010539	GN010539.1	A2AR02	59.1	396	551	752	2.70e-89	293	PPIG_MOUSE	Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (Cyclophilin G) (Rotamase G)	Mus musculus (Mouse)	protein folding [GO:0006457]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0003755; GO:0005634; GO:0005829; GO:0006457; GO:0016018; GO:0016363; GO:0016607
GN010543	GN010543.1	Q7SXW0	49.1	226	363	359	2.08e-64	211	S2539_DANRE	Mitochondrial glutathione transporter SLC25A39 (Solute carrier family 25 member 39)	Danio rerio (Zebrafish) (Brachydanio rerio)	glutathione import into mitochondrion [GO:0160007]; heme biosynthetic process [GO:0006783]; manganese ion transport [GO:0006828]; mitochondrial transmembrane transport [GO:1990542]	2 iron, 2 sulfur cluster binding [GO:0051537]; metallochaperone activity [GO:0016530]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0006783; GO:0006828; GO:0016530; GO:0051537; GO:0160007; GO:1990542
GN010546	GN010546.1	Q21281	39.4	104	148	2104	8.04e-16	76.6	MUP4_CAEEL	Transmembrane matrix receptor MUP-4 (Muscle-positioning protein 4)	Caenorhabditis elegans		calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]	cytoskeleton [GO:0005856]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; hemidesmosome [GO:0030056]; hemidesmosome associated protein complex [GO:0098733]; plasma membrane [GO:0005886]	GO:0005201; GO:0005509; GO:0005576; GO:0005856; GO:0005886; GO:0030056; GO:0031012; GO:0098733
GN010547	GN010547.1	P13944	29.5	122	155	3124	2.98e-16	78.2	COCA1_CHICK	Collagen alpha-1(XII) chain (Fibrochimerin)	Gallus gallus (Chicken)	endodermal cell differentiation [GO:0035987]		interstitial matrix [GO:0005614]	GO:0005614; GO:0035987
GN010548	GN010548.1	P31335	67.0	588	594	593	1.17e-285	793	PUR9_CHICK	Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)]	Gallus gallus (Chicken)	'de novo' IMP biosynthetic process [GO:0006189]	IMP cyclohydrolase activity [GO:0003937]; phosphoribosylaminoimidazolecarboxamide formyltransferase activity [GO:0004643]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]	GO:0003937; GO:0004643; GO:0005829; GO:0006189; GO:0042803
GN010557	GN010557.1	Q9Z2P8	36.0	89	189	102	7.79e-09	54.3	VAMP5_MOUSE	Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)	Mus musculus (Mouse)	Golgi to plasma membrane protein transport [GO:0043001]; skeletal muscle tissue development [GO:0007519]		cell surface [GO:0009986]; cytoplasmic vesicle membrane [GO:0030659]; intercalated disc [GO:0014704]; late endosome [GO:0005770]; organelle membrane [GO:0031090]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GO:0005770; GO:0005802; GO:0005886; GO:0007519; GO:0009986; GO:0014704; GO:0030659; GO:0031090; GO:0043001; GO:0048471
GN010561	GN010561.1	P79763	51.2	293	715	693	1.42e-87	292	FSHR_CHICK	Follicle-stimulating hormone receptor (FSH-R) (Follitropin receptor)	Gallus gallus (Chicken)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]	follicle-stimulating hormone receptor activity [GO:0004963]; G protein-coupled peptide receptor activity [GO:0008528]	membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004963; GO:0005886; GO:0007186; GO:0007189; GO:0008528; GO:0008584; GO:0009755; GO:0016020; GO:0033686; GO:0042699; GO:0043235; GO:0051897; GO:0070374; GO:0071372
GN010562	GN010562.1	Q99PP7	29.4	974	946	1142	3.05e-96	331	TRI33_MOUSE	E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)	Mus musculus (Mouse)	gene expression [GO:0010467]; negative regulation of BMP signaling pathway [GO:0030514]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]	co-SMAD binding [GO:0070410]; promoter-specific chromatin binding [GO:1990841]; R-SMAD binding [GO:0070412]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0008270; GO:0010467; GO:0016567; GO:0017015; GO:0030514; GO:0061630; GO:0070410; GO:0070412; GO:1990841
GN010566	GN010566.1	Q9BV94	63.7	355	722	578	1.07e-165	492	EDEM2_HUMAN	ER degradation-enhancing alpha-mannosidase-like protein 2	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; endoplasmic reticulum mannose trimming [GO:1904380]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; trimming of terminal mannose on C branch [GO:0036510]; ubiquitin-dependent glycoprotein ERAD pathway [GO:0097466]; viral protein processing [GO:0019082]	calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; membrane [GO:0016020]	GO:0004571; GO:0005509; GO:0005783; GO:0005788; GO:0005975; GO:0016020; GO:0019082; GO:0030968; GO:0036503; GO:0036510; GO:0044322; GO:0097466; GO:1904154; GO:1904380
GN010567	GN010567.1	Q9FY48	25.6	297	654	1625	6.47e-11	69.7	KEG_ARATH	E3 ubiquitin-protein ligase KEG (EC 2.3.2.27) (EC 2.7.11.1) (Protein KEEP ON GOING) (RING finger protein KEG) (RING-type E3 ubiquitin transferase KEG)	Arabidopsis thaliana (Mouse-ear cress)	abscisic acid-activated signaling pathway [GO:0009738]; defense response [GO:0006952]; developmental growth [GO:0048589]; endosomal transport [GO:0016197]; late endosome to vacuole transport [GO:0045324]; negative regulation of abscisic acid-activated signaling pathway [GO:0009788]; protein ubiquitination [GO:0016567]; response to abscisic acid [GO:0009737]; secretion by cell [GO:0032940]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; trans-Golgi network [GO:0005802]	GO:0004672; GO:0004674; GO:0004842; GO:0005524; GO:0005737; GO:0005769; GO:0005802; GO:0006952; GO:0009737; GO:0009738; GO:0009788; GO:0016197; GO:0016567; GO:0032940; GO:0045324; GO:0048589; GO:0061630; GO:0106310
GN010568	GN010568.1	Q8R367	36.8	185	213	199	1.68e-29	111	RERG_MOUSE	Ras-related and estrogen-regulated growth inhibitor (EC 3.6.5.2)	Mus musculus (Mouse)	establishment or maintenance of cell polarity [GO:0007163]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; Ras protein signal transduction [GO:0007265]; response to hormone [GO:0009725]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0001650; GO:0003924; GO:0003925; GO:0005525; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0007163; GO:0007265; GO:0008285; GO:0009725; GO:0030308
GN010569	GN010569.1	O35796	32.7	220	220	279	6.39e-22	94.0	C1QBP_RAT	Complement component 1 Q subcomponent-binding protein, mitochondrial (GC1q-R protein) (Glycoprotein gC1qBP) (C1qBP)	Rattus norvegicus (Rat)	cytosolic ribosome assembly [GO:0042256]; immune response [GO:0006955]; mitochondrial RNA catabolic process [GO:0000957]; negative regulation of defense response to virus [GO:0050687]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type II interferon production [GO:0032689]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of complement activation [GO:0030449]	adrenergic receptor binding [GO:0031690]; C5-methylcytidine-containing RNA reader activity [GO:0062153]; complement component C1q complex binding [GO:0001849]; enzyme inhibitor activity [GO:0004857]; hyaluronic acid binding [GO:0005540]; kininogen binding [GO:0030984]; mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; protein kinase C binding [GO:0005080]; transcription corepressor activity [GO:0003714]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]	GO:0000122; GO:0000957; GO:0001849; GO:0003714; GO:0003729; GO:0004857; GO:0005080; GO:0005540; GO:0005576; GO:0005634; GO:0005730; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0005886; GO:0006955; GO:0009986; GO:0016020; GO:0030449; GO:0030984; GO:0031690; GO:0032689; GO:0032695; GO:0039534; GO:0039536; GO:0042256; GO:0043065; GO:0043491; GO:0045785; GO:0048025; GO:0048786; GO:0050687; GO:0051897; GO:0062153; GO:0070131; GO:0090023; GO:0097177; GO:0098978; GO:0098982; GO:1900026; GO:1901165; GO:2000042; GO:2000510
GN010571	GN010571.1	Q8WVM8	65.0	552	551	642	1.28e-254	714	SCFD1_HUMAN	Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2)	Homo sapiens (Human)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of autophagosome assembly [GO:1902902]; post-Golgi vesicle-mediated transport [GO:0006892]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein transport [GO:0051223]; response to toxic substance [GO:0009636]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	protein-containing complex binding [GO:0044877]; syntaxin binding [GO:0019905]	cis-Golgi network [GO:0005801]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]	GO:0000139; GO:0005789; GO:0005798; GO:0005801; GO:0005829; GO:0006888; GO:0006890; GO:0006892; GO:0009636; GO:0019905; GO:0032580; GO:0044877; GO:0051223; GO:0060628; GO:1902902
GN010572	GN010572.1	A6H782	51.4	395	468	490	9.04e-127	380	TEKT3_BOVIN	Tektin-3	Bos taurus (Bovine)	cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317]; regulation of brood size [GO:0060378]		acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; outer acrosomal membrane [GO:0002081]; sperm flagellum [GO:0036126]	GO:0001669; GO:0002080; GO:0002081; GO:0005879; GO:0015630; GO:0030317; GO:0036126; GO:0060271; GO:0060294; GO:0060378; GO:0160111
GN010575	GN010575.1	Q29485	37.4	91	246	810	2.02e-10	63.9	PLMN_ERIEU	Plasminogen [Cleaved into: Plasmin (EC 3.4.21.7); Plasmin heavy chain A; Plasmin light chain B; Angiostatin]	Erinaceus europaeus (Western European hedgehog)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0004252; GO:0005102; GO:0005576; GO:0006508
GN010577	GN010577.1	Q3T058	59.1	369	504	524	1.07e-143	426	EI2BD_BOVIN	Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta)	Bos taurus (Bovine)	cytoplasmic translational initiation [GO:0002183]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]	GO:0001541; GO:0002183; GO:0003743; GO:0005085; GO:0005737; GO:0005829; GO:0005851; GO:0006413; GO:0014003; GO:0042552; GO:0050852
GN010582	GN010582.1	O57321	32.7	471	490	543	1.55e-84	273	EAA1_AMBTI	Excitatory amino acid transporter 1 (SEAAT1) (Sodium-dependent glutamate/aspartate transporter) (GLAST)	Ambystoma tigrinum (Eastern tiger salamander)	chloride transmembrane transport [GO:1902476]; D-aspartate import across plasma membrane [GO:0070779]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamate import across plasma membrane [GO:0098712]; potassium ion transmembrane transport [GO:0071805]	glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	plasma membrane [GO:0005886]	GO:0005314; GO:0005886; GO:0015175; GO:0015501; GO:0070779; GO:0071805; GO:0098712; GO:0140009; GO:1902476
GN010583	GN010583.1	Q99MZ7	56.2	274	299	303	2.95e-105	311	PECR_MOUSE	Peroxisomal trans-2-enoyl-CoA reductase (TERP) (EC 1.3.1.38)	Mus musculus (Mouse)	fatty acid elongation [GO:0030497]; phytol metabolic process [GO:0033306]	signaling receptor binding [GO:0005102]; trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166]	intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0005102; GO:0005739; GO:0005777; GO:0005778; GO:0019166; GO:0030497; GO:0033306; GO:0043231
GN010584	GN010584.1	A2VDC2	64.8	344	346	385	2.77e-147	423	HIBCH_XENLA	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H)	Xenopus laevis (African clawed frog)	L-valine catabolic process [GO:0006574]	3-hydroxyisobutyryl-CoA hydrolase activity [GO:0003860]	mitochondrion [GO:0005739]	GO:0003860; GO:0005739; GO:0006574
GN010586	GN010586.1	Q8WXR4	34.7	752	1236	1341	1.00e-135	451	MYO3B_HUMAN	Myosin-IIIb (EC 2.7.11.1)	Homo sapiens (Human)	auditory receptor cell stereocilium organization [GO:0060088]; cochlea morphogenesis [GO:0090103]; positive regulation of filopodium assembly [GO:0051491]; regulation of actin filament length [GO:0030832]; sensory perception of sound [GO:0007605]	ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; filopodium tip [GO:0032433]; myosin complex [GO:0016459]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; stereocilium tip [GO:0032426]	GO:0000146; GO:0001750; GO:0001917; GO:0004674; GO:0005524; GO:0005737; GO:0007605; GO:0016459; GO:0030832; GO:0032426; GO:0032433; GO:0051491; GO:0060088; GO:0090103; GO:0106310
GN010587	GN010587.1	F6QRE9	32.2	453	1544	1637	2.13e-52	207	ERIC3_MOUSE	Glutamate rich 3	Mus musculus (Mouse)	cilium assembly [GO:0060271]		axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; non-motile cilium [GO:0097730]	GO:0005737; GO:0005929; GO:0005930; GO:0060271; GO:0097730
GN010589	GN010589.1	Q5ZM14	46.9	113	306	333	5.93e-25	105	NHRF1_CHICK	Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)	Gallus gallus (Chicken)	bile acid secretion [GO:0032782]; glutathione transport [GO:0034635]; negative regulation of cell motility [GO:2000146]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; protein localization to plasma membrane [GO:0072659]; regulation of protein kinase activity [GO:0045859]; renal absorption [GO:0070293]	chloride channel regulator activity [GO:0017081]; protein-membrane adaptor activity [GO:0043495]; signaling receptor binding [GO:0005102]	apical plasma membrane [GO:0016324]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; filopodium [GO:0030175]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; ruffle [GO:0001726]	GO:0001726; GO:0005102; GO:0005737; GO:0005902; GO:0010642; GO:0012505; GO:0016324; GO:0017081; GO:0030175; GO:0031528; GO:0032782; GO:0034635; GO:0043495; GO:0045859; GO:0051898; GO:0070293; GO:0071944; GO:0072659; GO:2000146
GN010591	GN010591.1	Q9FT73	25.8	298	354	705	9.38e-25	108	RECQ2_ARATH	ATP-dependent DNA helicase Q-like 2 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ2) (RecQ-like protein 2) (AtRQ2) (AtRecQ2) (AtRecQl2)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; four-way junction helicase activity [GO:0009378]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; mediator complex [GO:0016592]; nucleus [GO:0005634]	GO:0003676; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0009378; GO:0016592; GO:0016887; GO:0043138
GN010594	GN010594.1	Q155U0	58.9	819	786	827	3.16e-316	887	VPS51_DANRE	Vacuolar protein sorting-associated protein 51 homolog (Protein fat-free)	Danio rerio (Zebrafish) (Brachydanio rerio)	endocytic recycling [GO:0032456]; Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; lipid digestion [GO:0044241]; lysosomal transport [GO:0007041]; regulation of phospholipase activity [GO:0010517]; retrograde transport, endosome to Golgi [GO:0042147]	small GTPase binding [GO:0031267]	cytosol [GO:0005829]; EARP complex [GO:1990745]; GARP complex [GO:0000938]; membrane [GO:0016020]; recycling endosome [GO:0055037]	GO:0000938; GO:0005829; GO:0007030; GO:0007041; GO:0010517; GO:0016020; GO:0031267; GO:0032456; GO:0042147; GO:0044241; GO:0048193; GO:0055037; GO:1990745
GN010595	GN010595.1	Q5AXT5	29.1	409	967	745	9.71e-36	149	PIF1_EMENI	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]	GO:0000723; GO:0003697; GO:0005524; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0043139; GO:0043596; GO:0071932
GN010598	GN010598.1	Q5AXT5	29.1	409	967	745	9.71e-36	149	PIF1_EMENI	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]	GO:0000723; GO:0003697; GO:0005524; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0043139; GO:0043596; GO:0071932
GN010602	GN010602.1	Q5W1J6	37.1	210	994	759	8.76e-27	121	FOXM1_XENLA	Forkhead box protein M1 (XlFoxM1)	Xenopus laevis (African clawed frog)	DNA damage response, signal transduction by p53 class mediator [GO:0030330]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of double-strand break repair [GO:2000781]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000086; GO:0000977; GO:0003700; GO:0005634; GO:0006355; GO:0006357; GO:0007346; GO:0030330; GO:0042127; GO:2000781
GN010603	GN010603.1	P13277	50.3	183	191	322	2.61e-51	170	CYSP1_HOMAM	Digestive cysteine proteinase 1 (EC 3.4.22.-)	Homarus americanus (American lobster)	proteolysis [GO:0006508]	cysteine-type peptidase activity [GO:0008234]		GO:0006508; GO:0008234
GN010604	GN010604.1	Q8C8U0	66.7	51	90	969	3.40e-11	60.8	LIPB1_MOUSE	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1)	Mus musculus (Mouse)	cortical microtubule organization [GO:0043622]; neuromuscular junction development [GO:0007528]		cell cortex [GO:0005938]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]	GO:0005829; GO:0005886; GO:0005938; GO:0007528; GO:0043622; GO:0048786
GN010606	GN010606.1	Q8C8U0	40.1	818	908	969	4.71e-152	476	LIPB1_MOUSE	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1)	Mus musculus (Mouse)	cortical microtubule organization [GO:0043622]; neuromuscular junction development [GO:0007528]		cell cortex [GO:0005938]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]	GO:0005829; GO:0005886; GO:0005938; GO:0007528; GO:0043622; GO:0048786
GN010607	GN010607.1	V5NAL9	27.5	681	688	899	1.92e-64	233	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN010608	GN010608.1	V5NAL9	28.0	678	700	899	5.55e-63	229	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN010609	GN010609.1	Q0P4Y8	48.7	495	641	707	5.35e-142	432	LMF2_XENTR	Lipase maturation factor 2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	protein maturation [GO:0051604]		endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0051604
GN010614	GN010614.1	Q3T106	65.1	63	204	235	5.33e-21	90.1	SRSF7_BOVIN	Serine/arginine-rich splicing factor 7 (Splicing factor, arginine/serine-rich 7)	Bos taurus (Bovine)	negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000381; GO:0003723; GO:0005634; GO:0005737; GO:0008270; GO:0048025
GN010615	GN010615.1	Q3T106	46.1	115	291	235	6.17e-28	110	SRSF7_BOVIN	Serine/arginine-rich splicing factor 7 (Splicing factor, arginine/serine-rich 7)	Bos taurus (Bovine)	negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000381; GO:0003723; GO:0005634; GO:0005737; GO:0008270; GO:0048025
GN010619	GN010619.1	Q0VDN7	39.2	587	578	615	4.23e-116	360	RUND1_MOUSE	RUN domain-containing protein 1	Mus musculus (Mouse)	in utero embryonic development [GO:0001701]			GO:0001701
GN010621	GN010621.1	Q8BJ56	40.8	446	608	486	2.30e-100	317	PLPL2_MOUSE	Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin)	Mus musculus (Mouse)	diacylglycerol biosynthetic process [GO:0006651]; intracellular triglyceride homeostasis [GO:0035356]; lipid catabolic process [GO:0016042]; lipid droplet disassembly [GO:1905691]; lipid droplet fusion [GO:0160077]; lipid droplet organization [GO:0034389]; lipid homeostasis [GO:0055088]; lipid storage [GO:0019915]; positive regulation of triglyceride catabolic process [GO:0010898]; retinoid metabolic process [GO:0001523]; triglyceride catabolic process [GO:0019433]	A2-type glycerophospholipase activity [GO:0004623]; acylglycerol O-acyltransferase activity [GO:0016411]; diolein transacylation activity [GO:0051265]; mono-olein transacylation activity [GO:0051264]; retinyl-palmitate esterase activity [GO:0050253]; triacylglycerol lipase activity [GO:0004806]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0001523; GO:0004623; GO:0004806; GO:0005654; GO:0005737; GO:0005811; GO:0005829; GO:0005886; GO:0006651; GO:0010898; GO:0016020; GO:0016042; GO:0016411; GO:0019433; GO:0019915; GO:0034389; GO:0035356; GO:0050253; GO:0051264; GO:0051265; GO:0055088; GO:0160077; GO:1905691
GN010622	GN010622.1	A0A1S4GHV7	56.0	327	963	493	1.37e-127	398	FUTA_ANOGA	Core alpha-(1,3)-fucosyltransferase (EC 2.4.1.214) (Fucosyltransferase A) (AgFucTA)	Anopheles gambiae (African malaria mosquito)	N-glycan processing [GO:0006491]	glycoprotein 3-alpha-L-fucosyltransferase activity [GO:0018392]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0018392; GO:0032580
GN010632	GN010632.1	Q9UBP9	62.1	182	453	304	4.60e-73	235	GULP1_HUMAN	PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP)	Homo sapiens (Human)	apoptotic process [GO:0006915]; phagocytosis, engulfment [GO:0006911]		cytoplasm [GO:0005737]	GO:0005737; GO:0006911; GO:0006915
GN010633	GN010633.1	P56590	22.9	314	329	524	4.96e-25	108	CP1A1_CANLF	Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (Cytochrome P450 form 6) (Cytochrome P450-C) (Cytochrome P450-P1) (DAH1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)	Canis lupus familiaris (Dog) (Canis familiaris)	estrogen metabolic process [GO:0008210]; fatty acid metabolic process [GO:0006631]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; toxin metabolic process [GO:0009404]; xenobiotic catabolic process [GO:0042178]	arachidonate 11,12-epoxygenase activity [GO:0008405]; arachidonate 14,15-epoxygenase activity [GO:0008404]; arachidonate 8,9-epoxygenase activity [GO:0106302]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; fatty acid omega-1 hydroxylase activity [GO:0120502]; heme binding [GO:0020037]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; hydroperoxy icosatetraenoate dehydratase activity [GO:0106256]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005506; GO:0005737; GO:0005739; GO:0005743; GO:0005789; GO:0006631; GO:0006706; GO:0008210; GO:0008395; GO:0008404; GO:0008405; GO:0009404; GO:0016712; GO:0020037; GO:0030544; GO:0042178; GO:0042572; GO:0051879; GO:0101020; GO:0101021; GO:0106256; GO:0106302; GO:0120502
GN010635	GN010635.1	O74508	33.6	134	279	424	2.01e-09	61.2	SPP1_SCHPO	Set1 complex component spp1 (Set1C component spp1) (COMPASS component spp1) (Complex proteins associated with set1 protein spp1)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	positive regulation of DNA-templated transcription [GO:0045893]; subtelomeric heterochromatin formation [GO:0031509]; transcription initiation-coupled chromatin remodeling [GO:0045815]		chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]	GO:0000781; GO:0000785; GO:0005634; GO:0005829; GO:0031509; GO:0045815; GO:0045893; GO:0048188
GN010636	GN010636.1	Q9QXF7	28.0	460	490	501	4.15e-51	184	CP2J4_RAT	Cytochrome P450 2J4 (EC 1.14.14.1) (CYPIIJ4)	Rattus norvegicus (Rat)	arachidonate metabolic process [GO:0019369]; epoxygenase P450 pathway [GO:0019373]; female pregnancy [GO:0007565]; icosanoid metabolic process [GO:0006690]; linoleic acid metabolic process [GO:0043651]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of tumor necrosis factor production [GO:0032760]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; xenobiotic metabolic process [GO:0006805]	arachidonate 11,12-epoxygenase activity [GO:0008405]; arachidonate 14,15-epoxygenase activity [GO:0008404]; arachidonate 5,6-epoxygenase activity [GO:0106301]; arachidonate epoxygenase activity [GO:0008392]; arachidonate monooxygenase activity [GO:0008391]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; isomerase activity [GO:0016853]; linoleic acid epoxygenase activity [GO:0071614]; NADPH-hemoprotein reductase activity [GO:0003958]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0001523; GO:0003958; GO:0005506; GO:0005737; GO:0005783; GO:0005789; GO:0006690; GO:0006805; GO:0007565; GO:0008391; GO:0008392; GO:0008404; GO:0008405; GO:0016712; GO:0016853; GO:0019369; GO:0019373; GO:0020037; GO:0032760; GO:0032966; GO:0035359; GO:0042572; GO:0043651; GO:0045722; GO:0071614; GO:0106301; GO:1903055
GN010638	GN010638.1	P05180	27.6	464	467	491	1.01e-43	163	CP2H1_CHICK	Cytochrome P450 2H1 (EC 1.14.14.1) (CYPIIH1) (Cytochrome P450 PB15) (Cytochrome P450 PCHP3)	Gallus gallus (Chicken)	epoxygenase P450 pathway [GO:0019373]; response to xenobiotic stimulus [GO:0009410]; xenobiotic metabolic process [GO:0006805]	arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005737; GO:0005789; GO:0006805; GO:0008392; GO:0009410; GO:0016712; GO:0019373; GO:0020037
GN010639	GN010639.1	O93257	48.0	542	649	632	2.67e-175	516	XRCC6_CHICK	DNA repair protein Ku70 (EC 4.2.99.18) (EC 5.6.2.4) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP/AP lyase Ku70) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (DNA repair protein XRCC6) (Ku autoantigen protein p70 homolog) (Ku70) (X-ray repair cross-complementing protein 5)	Gallus gallus (Chicken)	cellular response to gamma radiation [GO:0071480]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of DNA-templated transcription [GO:0045892]; telomere maintenance [GO:0000723]	3'-5' DNA helicase activity [GO:0043138]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP hydrolysis activity [GO:0016887]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; RNA binding [GO:0003723]; telomeric repeat DNA binding [GO:0042162]	chromosome [GO:0005694]; Ku70:Ku80 complex [GO:0043564]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0000723; GO:0003684; GO:0003723; GO:0005634; GO:0005654; GO:0005694; GO:0006303; GO:0016887; GO:0042162; GO:0043138; GO:0043564; GO:0045892; GO:0051575; GO:0070419; GO:0071480; GO:0140078; GO:1990904
GN010645	GN010645.1	P97441	47.2	89	253	388	8.52e-16	79.3	ZNT3_MOUSE	Probable proton-coupled zinc antiporter SLC30A3 (Solute carrier family 30 member 3) (Zinc transporter 3) (ZnT-3)	Mus musculus (Mouse)	detoxification of zinc ion [GO:0010312]; positive regulation of transport [GO:0051050]; response to zinc ion [GO:0010043]; zinc ion import into lysosome [GO:0140916]; zinc ion import into synaptic vesicle [GO:0099180]; zinc ion transmembrane transport [GO:0071577]	AP-3 adaptor complex binding [GO:0035651]; zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826]	clathrin-sculpted vesicle [GO:0060198]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber [GO:0097457]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; microvesicle [GO:1990742]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; transmembrane transporter complex [GO:1902495]	GO:0005385; GO:0005737; GO:0005765; GO:0005770; GO:0005886; GO:0008021; GO:0010043; GO:0010312; GO:0030659; GO:0030672; GO:0031902; GO:0035651; GO:0043005; GO:0051050; GO:0060198; GO:0071577; GO:0097457; GO:0098686; GO:0098978; GO:0099180; GO:0140826; GO:0140916; GO:1902495; GO:1990742
GN010646	GN010646.1	Q9ULF5	36.6	541	580	831	3.28e-78	266	S39AA_HUMAN	Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10)	Homo sapiens (Human)	epithelial to mesenchymal transition [GO:0001837]; intracellular monoatomic cation homeostasis [GO:0030003]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]	monoatomic cation:bicarbonate symporter activity [GO:0140410]; protein tyrosine phosphatase activator activity [GO:0008160]; zinc ion transmembrane transporter activity [GO:0005385]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0001837; GO:0005385; GO:0005886; GO:0008160; GO:0016324; GO:0030003; GO:0071577; GO:0071578; GO:0140410
GN010647	GN010647.1	A7T1N0	24.0	1636	1581	1551	6.12e-85	311	TMP2L_NEMVE	Transient receptor potential cation channel subfamily M member-like 2 (nvTRPM2)	Nematostella vectensis (Starlet sea anemone)	calcium ion transmembrane transport [GO:0070588]; sodium ion transmembrane transport [GO:0035725]	ADP-ribose diphosphatase activity [GO:0047631]; ligand-gated calcium channel activity [GO:0099604]; ligand-gated sodium channel activity [GO:0015280]	plasma membrane [GO:0005886]	GO:0005886; GO:0015280; GO:0035725; GO:0047631; GO:0070588; GO:0099604
GN010653	GN010653.1	Q24292	23.8	991	1320	3556	3.27e-34	147	DS_DROME	Protein dachsous (Adherin)	Drosophila melanogaster (Fruit fly)	axonogenesis [GO:0007409]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; homophilic cell-cell adhesion [GO:0007156]; imaginal disc morphogenesis [GO:0007560]; negative regulation of hippo signaling [GO:0035331]; positive regulation of hippo signaling [GO:0035332]; protein localization involved in establishment of planar polarity [GO:0090251]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; apicolateral plasma membrane [GO:0016327]; plasma membrane [GO:0005886]	GO:0001736; GO:0005509; GO:0005886; GO:0005912; GO:0007156; GO:0007409; GO:0007560; GO:0016327; GO:0030855; GO:0035331; GO:0035332; GO:0042067; GO:0044331; GO:0070161; GO:0090251
GN010655	GN010655.1	Q5ZID0	38.2	314	492	296	1.18e-63	211	NMRL1_CHICK	NmrA-like family domain-containing protein 1	Gallus gallus (Chicken)			nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0005634; GO:0048471
GN010659	GN010659.1	Q63ZI0	54.6	196	252	374	4.07e-60	197	KCNK9_XENLA	Potassium channel subfamily K member 9	Xenopus laevis (African clawed frog)	potassium ion import across plasma membrane [GO:1990573]; stabilization of membrane potential [GO:0030322]	outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]	GO:0005886; GO:0015271; GO:0022841; GO:0030322; GO:1990573
GN010660	GN010660.1	Q9I7U4	35.5	121	324	18141	1.26e-14	78.6	TITIN_DROME	Titin (D-Titin) (Kettin)	Drosophila melanogaster (Fruit fly)	mesoderm development [GO:0007498]; mitotic chromosome condensation [GO:0007076]; myoblast fusion [GO:0007520]; regulation of hemocyte proliferation [GO:0035206]; sarcomere organization [GO:0045214]; sister chromatid cohesion [GO:0007062]; somatic muscle development [GO:0007525]; visceral muscle development [GO:0007522]	actin binding [GO:0003779]; structural constituent of muscle [GO:0008307]	chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; I band [GO:0031674]; nucleus [GO:0005634]; sarcomere [GO:0030017]; striated muscle myosin thick filament [GO:0005863]; Z disc [GO:0030018]	GO:0000794; GO:0003779; GO:0005634; GO:0005694; GO:0005737; GO:0005863; GO:0007062; GO:0007076; GO:0007498; GO:0007520; GO:0007522; GO:0007525; GO:0008307; GO:0030017; GO:0030018; GO:0031674; GO:0035206; GO:0045214
GN010662	GN010662.1	Q7NBW0	51.0	51	469	391	5.26e-09	61.6	DNAJ_MYCGA	Chaperone protein DnaJ	Mycoplasmoides gallisepticum (strain R(low / passage 15 / clone 2)) (Mycoplasma gallisepticum)	protein refolding [GO:0042026]; response to heat [GO:0009408]	ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005524; GO:0005737; GO:0008270; GO:0009408; GO:0031072; GO:0042026
GN010664	GN010664.1	Q5TZ51	37.2	145	178	177	3.59e-29	108	MPV17_DANRE	Mitochondrial inner membrane protein Mpv17 (Protein Mpv17)	Danio rerio (Zebrafish) (Brachydanio rerio)	developmental pigmentation [GO:0048066]; iridophore differentiation [GO:0050935]; liver development [GO:0001889]; regulation of mitochondrion organization [GO:0010821]; regulation of skeletal muscle fiber development [GO:0048742]; regulation of triglyceride metabolic process [GO:0090207]	channel activity [GO:0015267]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0001889; GO:0005739; GO:0005743; GO:0010821; GO:0015267; GO:0048066; GO:0048742; GO:0050935; GO:0090207
GN010665	GN010665.1	Q4H4B6	33.1	1156	1849	1724	5.35e-122	428	SCRIB_DANRE	Protein scribble homolog (Scribble1)	Danio rerio (Zebrafish) (Brachydanio rerio)	activation of GTPase activity [GO:0090630]; anterior/posterior axon guidance [GO:0033564]; apoptotic process involved in morphogenesis [GO:0060561]; cell migration [GO:0016477]; cell population proliferation [GO:0008283]; cell-cell adhesion [GO:0098609]; commissural neuron axon guidance [GO:0071679]; convergent extension involved in gastrulation [GO:0060027]; establishment of apical/basal cell polarity [GO:0035089]; establishment of mitotic spindle orientation [GO:0000132]; establishment of planar polarity [GO:0001736]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; motor neuron migration [GO:0097475]; negative regulation of mitotic cell cycle [GO:0045930]; neural tube formation [GO:0001841]; neuromast development [GO:0048884]; neuron migration [GO:0001764]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive chemotaxis [GO:0050918]; positive regulation of apoptotic process [GO:0043065]; receptor clustering [GO:0043113]; vasculature development [GO:0001944]	protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; basolateral plasma membrane [GO:0016323]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]	GO:0000132; GO:0001736; GO:0001764; GO:0001841; GO:0001944; GO:0005737; GO:0005886; GO:0005911; GO:0005912; GO:0008283; GO:0014069; GO:0016020; GO:0016323; GO:0016477; GO:0019901; GO:0030027; GO:0033564; GO:0035089; GO:0043065; GO:0043113; GO:0045197; GO:0045930; GO:0046982; GO:0048884; GO:0050918; GO:0060027; GO:0060561; GO:0070161; GO:0071679; GO:0090630; GO:0097475; GO:0098609; GO:0098793; GO:0098794; GO:0098887
GN010668	GN010668.1	Q0V9W6	33.1	426	447	529	4.89e-54	191	BTBD6_XENTR	BTB/POZ domain-containing protein 6	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			cytoplasm [GO:0005737]	GO:0005737
GN010669	GN010669.1	Q7ZV80	49.8	237	237	237	6.56e-65	204	SPF30_DANRE	Survival of motor neuron-related-splicing factor 30 (Survival motor neuron domain-containing protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	mRNA processing [GO:0006397]	RNA binding [GO:0003723]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0015030; GO:0016607
GN010670	GN010670.1	Q5RID7	52.7	402	441	473	5.58e-151	440	SNX17_DANRE	Sorting nexin-17	Danio rerio (Zebrafish) (Brachydanio rerio)	endocytic recycling [GO:0032456]; intracellular protein transport [GO:0006886]; signal transduction [GO:0007165]	phosphatidylinositol binding [GO:0035091]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]	GO:0005737; GO:0005769; GO:0005829; GO:0006886; GO:0007165; GO:0030659; GO:0031410; GO:0032456; GO:0035091
GN010671	GN010671.1	Q8BH00	64.6	161	160	487	2.44e-69	220	AL8A1_MOUSE	2-aminomuconic semialdehyde dehydrogenase (EC 1.2.1.32) (Aldehyde dehydrogenase family 8 member A1) (Retinal dehydrogenase 4)	Mus musculus (Mouse)	9-cis-retinoic acid biosynthetic process [GO:0042904]; retinal metabolic process [GO:0042574]; retinoic acid metabolic process [GO:0042573]	aminomuconate-semialdehyde dehydrogenase activity [GO:0047102]; retinal dehydrogenase (NAD+) activity [GO:0001758]	cytoplasm [GO:0005737]	GO:0001758; GO:0005737; GO:0042573; GO:0042574; GO:0042904; GO:0047102
GN010676	GN010676.1	Q28260	32.6	132	297	739	3.92e-12	70.1	VCAM1_CANLF	Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1]	Canis lupus familiaris (Dog) (Canis familiaris)	cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]	integrin binding [GO:0005178]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005178; GO:0005576; GO:0005886; GO:0007155; GO:0098609
GN010681	GN010681.1	Q8IV38	45.8	365	419	441	1.10e-107	327	ANKY2_HUMAN	Ankyrin repeat and MYND domain-containing protein 2	Homo sapiens (Human)		enzyme binding [GO:0019899]	cilium [GO:0005929]	GO:0005929; GO:0019899
GN010682	GN010682.1	Q6IRP4	50.3	199	202	336	2.17e-65	207	ABHDD_XENLA	Protein ABHD13 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 13) (Abhydrolase domain-containing protein 13)	Xenopus laevis (African clawed frog)		palmitoyl-(protein) hydrolase activity [GO:0008474]	membrane [GO:0016020]	GO:0008474; GO:0016020
GN010683	GN010683.1	O08561	56.7	726	915	816	5.70e-255	736	PI4KB_RAT	Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67)	Rattus norvegicus (Rat)	inner ear development [GO:0048839]; lysosome organization [GO:0007040]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]	1-phosphatidylinositol 4-kinase activity [GO:0004430]; 14-3-3 protein binding [GO:0071889]	cytoplasmic side of trans-Golgi network membrane [GO:0160281]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitochondrial outer membrane [GO:0005741]; rough endoplasmic reticulum membrane [GO:0030867]	GO:0000139; GO:0004430; GO:0005741; GO:0005794; GO:0007040; GO:0030867; GO:0046854; GO:0048015; GO:0048839; GO:0071889; GO:0160281
GN010684	GN010684.1	Q8CHH5	34.4	154	1616	1074	2.75e-12	75.9	BICRL_MOUSE	BRD4-interacting chromatin-remodeling complex-associated protein-like	Mus musculus (Mouse)	chromatin remodeling [GO:0006338]; negative regulation of cell differentiation [GO:0045596]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]		chromatin [GO:0000785]; GBAF complex [GO:0140288]; SWI/SNF complex [GO:0016514]	GO:0000785; GO:0006338; GO:0006357; GO:0008284; GO:0016514; GO:0045596; GO:0045893; GO:0140288; GO:1902459
GN010685	GN010685.1	Q9BEG8	29.8	597	580	734	6.33e-87	288	S26A2_BOVIN	Sulfate transporter (Solute carrier family 26 member 2)	Bos taurus (Bovine)	chloride transmembrane transport [GO:1902476]; chondrocyte differentiation [GO:0002062]; chondrocyte proliferation [GO:0035988]; sulfate transmembrane transport [GO:1902358]	chloride:bicarbonate antiporter activity [GO:0140900]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0002062; GO:0005886; GO:0008271; GO:0015116; GO:0016324; GO:0019531; GO:0035988; GO:0140900; GO:1902358; GO:1902476
GN010686	GN010686.1	Q86Z23	38.7	119	128	238	1.58e-10	59.7	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN010687	GN010687.1	P43679	31.3	80	134	455	2.21e-11	63.2	ACHB3_CHICK	Neuronal acetylcholine receptor subunit beta-3	Gallus gallus (Chicken)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098793; GO:0099171
GN010688	GN010688.1	P54131	30.1	299	375	499	1.27e-37	144	ACHA7_BOVIN	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Bos taurus (Bovine)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN010690	GN010690.1	P53809	51.7	203	221	214	1.32e-77	235	PPCT_RAT	Phosphatidylcholine transfer protein (PC-TP) (START domain-containing protein 2) (StARD2) (StAR-related lipid transfer protein 2)	Rattus norvegicus (Rat)	cholesterol metabolic process [GO:0008203]; negative regulation of cold-induced thermogenesis [GO:0120163]; phospholipid transport [GO:0015914]	phosphatidylcholine binding [GO:0031210]; phosphatidylcholine intramembrane carrier activity [GO:0008525]	cytosol [GO:0005829]	GO:0005829; GO:0008203; GO:0008525; GO:0015914; GO:0031210; GO:0120163
GN010691	GN010691.1	A7T1N0	32.2	1241	1230	1551	2.79e-190	602	TMP2L_NEMVE	Transient receptor potential cation channel subfamily M member-like 2 (nvTRPM2)	Nematostella vectensis (Starlet sea anemone)	calcium ion transmembrane transport [GO:0070588]; sodium ion transmembrane transport [GO:0035725]	ADP-ribose diphosphatase activity [GO:0047631]; ligand-gated calcium channel activity [GO:0099604]; ligand-gated sodium channel activity [GO:0015280]	plasma membrane [GO:0005886]	GO:0005886; GO:0015280; GO:0035725; GO:0047631; GO:0070588; GO:0099604
GN010701	GN010701.1	B3EWZ5	37.2	148	169	5145	2.89e-19	87.4	MLRP1_ACRMI	MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN010702	GN010702.1	B3EWZ5	25.3	1007	1687	5145	1.56e-59	231	MLRP1_ACRMI	MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN010703	GN010703.1	Q9ULA0	58.6	464	472	485	5.00e-200	566	DNPEP_HUMAN	Aspartyl aminopeptidase (EC 3.4.11.21)	Homo sapiens (Human)	peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]	aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004177; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006518; GO:0008270; GO:0042802; GO:0072562
GN010704	GN010704.1	Q6GL69	44.6	175	494	276	6.01e-37	140	MK67I_XENTR	MKI67 FHA domain-interacting nucleolar phosphoprotein-like	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		RNA binding [GO:0003723]	nucleolus [GO:0005730]	GO:0003723; GO:0005730
GN010705	GN010705.1	Q8T773	46.6	466	583	522	1.28e-154	456	MDH1B_BRAFL	Putative malate dehydrogenase 1B (EC 1.1.1.-)	Branchiostoma floridae (Florida lancelet) (Amphioxus)	malate metabolic process [GO:0006108]; NAD+ metabolic process [GO:0019674]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099]	L-malate dehydrogenase (NAD+) activity [GO:0030060]		GO:0006099; GO:0006107; GO:0006108; GO:0019674; GO:0030060
GN010706	GN010706.1	O16053	28.7	282	256	268	1.98e-11	65.9	CDV3_DROYA	Protein CDV3 homolog (Protein anon-2C9)	Drosophila yakuba (Fruit fly)			cytoplasm [GO:0005737]	GO:0005737
GN010708	GN010708.1	P41562	80.2	405	410	414	2.36e-247	681	IDHC_RAT	Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)	Rattus norvegicus (Rat)	2-oxoglutarate metabolic process [GO:0006103]; female gonad development [GO:0008585]; glutathione metabolic process [GO:0006749]; isocitrate metabolic process [GO:0006102]; NADPH regeneration [GO:0006740]; regulation of phospholipid biosynthetic process [GO:0071071]; regulation of phospholipid catabolic process [GO:0060696]; response to oxidative stress [GO:0006979]; response to steroid hormone [GO:0048545]; tricarboxylic acid cycle [GO:0006099]	identical protein binding [GO:0042802]; isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0000287; GO:0004450; GO:0005737; GO:0005739; GO:0005777; GO:0005782; GO:0005829; GO:0006099; GO:0006102; GO:0006103; GO:0006740; GO:0006749; GO:0006979; GO:0008585; GO:0042802; GO:0042803; GO:0048545; GO:0050661; GO:0051287; GO:0060696; GO:0071071
GN010709	GN010709.1	Q71SY5	41.9	563	756	747	2.86e-114	365	MED25_HUMAN	Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78)	Homo sapiens (Human)	negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chromatin binding [GO:0035563]; positive regulation of mediator complex assembly [GO:2001178]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]	nuclear retinoic acid receptor binding [GO:0042974]; nuclear retinoid X receptor binding [GO:0046965]; transcription coactivator binding [GO:0001223]	core mediator complex [GO:0070847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0001223; GO:0005634; GO:0005654; GO:0005667; GO:0032968; GO:0035563; GO:0042974; GO:0045944; GO:0046965; GO:0048147; GO:0051123; GO:0060261; GO:0070847; GO:2001178
GN010710	GN010710.1	Q60HH8	52.8	445	473	485	2.22e-164	476	AL3A2_MACFA	Aldehyde dehydrogenase family 3 member A2 (EC 1.2.1.3) (EC 1.2.1.94) (Fatty aldehyde dehydrogenase)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	hexadecanal metabolic process [GO:0046458]	3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; farnesal dehydrogenase (NAD+) activity [GO:0120553]; fatty aldehyde dehydrogenase (NAD+) activity [GO:0102673]; long-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0050061]; medium-chain fatty aldehyde dehydrogenase (NAD+) activity [GO:0052814]	endoplasmic reticulum membrane [GO:0005789]	GO:0004028; GO:0004029; GO:0005789; GO:0046458; GO:0050061; GO:0052814; GO:0102673; GO:0120553
GN010711	GN010711.1	Q9UGM1	37.2	148	152	479	6.98e-32	121	ACHA9_HUMAN	Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9)	Homo sapiens (Human)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of membrane potential [GO:0042391]; response to auditory stimulus [GO:0010996]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; cholinergic synapse [GO:0098981]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007204; GO:0007271; GO:0010996; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0051899; GO:0070373; GO:0095500; GO:0098981; GO:0099634; GO:1902495
GN010725	GN010725.1	Q9DGD1	39.2	232	271	464	6.82e-59	197	MGT4C_CHICK	Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.201) (MGAT6) (N-acetylglucosaminyltransferase VI) (GlcNAc-TVI) (GnT-VI) (N-glycan branching N-acetylglucosaminyltransferase VI)	Gallus gallus (Chicken)	protein N-linked glycosylation [GO:0006487]	acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0047253]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006487; GO:0008375; GO:0047253
GN010726	GN010726.1	P10895	44.3	625	604	756	3.68e-160	479	PLCD1_BOVIN	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)	Bos taurus (Bovine)	intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; phosphatidylinositol metabolic process [GO:0046488]	calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0120548]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004435; GO:0005509; GO:0005546; GO:0005737; GO:0005886; GO:0006629; GO:0035556; GO:0046488; GO:0120548
GN010727	GN010727.1	Q15111	32.7	147	177	1095	1.01e-11	65.9	PLCL1_HUMAN	Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP)	Homo sapiens (Human)	gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; negative regulation of cold-induced thermogenesis [GO:0120163]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; regulation of synaptic transmission, GABAergic [GO:0032228]; release of sequestered calcium ion into cytosol [GO:0051209]	C-type glycerophospholipase activity [GO:0004629]; phosphatidylinositol-4,5-bisphosphate phospholipase C activity [GO:0004435]	cytoplasm [GO:0005737]	GO:0004435; GO:0004629; GO:0005737; GO:0006629; GO:0007214; GO:0032228; GO:0035556; GO:0046488; GO:0048015; GO:0051209; GO:0120163
GN010728	GN010728.1	Q93YS4	37.5	555	675	751	6.33e-111	354	AB22G_ARATH	ABC transporter G family member 22 (ABC transporter ABCG.22) (AtABCG22) (White-brown complex homolog protein 23) (AtWBC23)	Arabidopsis thaliana (Mouse-ear cress)	response to water deprivation [GO:0009414]; transpiration [GO:0010148]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0005524; GO:0005739; GO:0005886; GO:0009414; GO:0010148; GO:0016887; GO:0140359
GN010729	GN010729.1	D3YV10	31.2	698	760	709	1.49e-50	192	CCD13_MOUSE	Coiled-coil domain-containing protein 13	Mus musculus (Mouse)	axoneme assembly [GO:0035082]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response [GO:0006974]; non-motile cilium assembly [GO:1905515]	microtubule binding [GO:0008017]	axonemal central pair [GO:0097540]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]	GO:0005813; GO:0006974; GO:0008017; GO:0031122; GO:0034451; GO:0035082; GO:0036064; GO:0097540; GO:1905515
GN010730	GN010730.1	O35165	56.9	211	213	212	4.05e-74	226	GOSR2_RAT	Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin)	Rattus norvegicus (Rat)	intra-Golgi vesicle-mediated transport [GO:0006891]; vesicle-mediated transport [GO:0016192]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; SNARE complex [GO:0031201]	GO:0000139; GO:0000149; GO:0005484; GO:0005789; GO:0005794; GO:0006891; GO:0012507; GO:0016192; GO:0031201; GO:0031902
GN010732	GN010732.1	Q8BHW9	39.0	218	1303	410	5.55e-29	124	SLNL1_MOUSE	Schlafen-like protein 1	Mus musculus (Mouse)				
GN010733	GN010733.1	O15442	40.4	285	262	326	7.00e-65	208	MPPD1_HUMAN	Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB)	Homo sapiens (Human)		cyclic-nucleotide phosphodiesterase activity [GO:0004112]		GO:0004112
GN010734	GN010734.1	Q9NSN8	37.2	495	465	517	1.56e-104	323	SNTG1_HUMAN	Gamma-1-syntrophin (G1SYN) (Syntrophin-4) (SYN4)	Homo sapiens (Human)	cell communication [GO:0007154]; synaptic signaling [GO:0099536]	structural molecule activity [GO:0005198]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; synapse [GO:0045202]; syntrophin complex [GO:0016013]	GO:0005198; GO:0005634; GO:0005737; GO:0005856; GO:0005886; GO:0007154; GO:0016010; GO:0016013; GO:0032587; GO:0045202; GO:0099536
GN010735	GN010735.1	Q5JVL4	53.8	638	641	640	4.32e-249	704	EFHC1_HUMAN	EF-hand domain-containing protein 1 (Myoclonin-1)	Homo sapiens (Human)	cerebral cortex cell migration [GO:0021795]; cilium-dependent cell motility [GO:0060285]; flagellated sperm motility [GO:0030317]; mitotic cytokinesis [GO:0000281]; mitotic spindle organization [GO:0007052]; regulation of cell division [GO:0051302]	alpha-tubulin binding [GO:0043014]; calcium ion binding [GO:0005509]	axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; centrosome [GO:0005813]; mitotic spindle [GO:0072686]; neuronal cell body [GO:0043025]; sperm flagellum [GO:0036126]; spindle pole [GO:0000922]	GO:0000281; GO:0000922; GO:0005509; GO:0005813; GO:0005879; GO:0005930; GO:0007052; GO:0021795; GO:0030317; GO:0036126; GO:0043014; GO:0043025; GO:0051302; GO:0060285; GO:0072686; GO:0160111
GN010736	GN010736.1	Q810W9	56.6	83	127	920	5.71e-24	99.0	WHRN_RAT	Whirlin (CASK-interacting protein CIP98)	Rattus norvegicus (Rat)	auditory receptor cell stereocilium organization [GO:0060088]; cerebellar Purkinje cell layer formation [GO:0021694]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of protein localization [GO:0045184]; inner ear receptor cell stereocilium organization [GO:0060122]; paranodal junction maintenance [GO:1990227]; positive regulation of gene expression [GO:0010628]; retina homeostasis [GO:0001895]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	actin filament [GO:0005884]; apical dendrite [GO:0097440]; axon collateral [GO:0044303]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; periciliary membrane compartment [GO:1990075]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium bundle [GO:0032421]; stereocilium tip [GO:0032426]; synapse [GO:0045202]; USH2 complex [GO:1990696]	GO:0001895; GO:0001917; GO:0002141; GO:0002142; GO:0005737; GO:0005884; GO:0005886; GO:0005929; GO:0007605; GO:0010628; GO:0019904; GO:0021694; GO:0030426; GO:0032391; GO:0032420; GO:0032421; GO:0032426; GO:0036064; GO:0042802; GO:0043025; GO:0043198; GO:0044303; GO:0045184; GO:0045202; GO:0048471; GO:0050910; GO:0050953; GO:0060088; GO:0060122; GO:0097440; GO:0098793; GO:0098794; GO:1990075; GO:1990227; GO:1990696
GN010737	GN010737.1	P07943	54.1	296	307	316	4.30e-105	312	ALDR_RAT	Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR)	Rattus norvegicus (Rat)	cellular hyperosmotic salinity response [GO:0071475]; cellular response to methylglyoxal [GO:0097238]; cellular response to peptide [GO:1901653]; D-sorbitol biosynthetic process [GO:0006061]; D-sorbitol metabolic process [GO:0006060]; daunorubicin metabolic process [GO:0044597]; doxorubicin metabolic process [GO:0044598]; epithelial cell maturation [GO:0002070]; fructose biosynthetic process [GO:0046370]; inner medullary collecting duct development [GO:0072061]; maternal process involved in female pregnancy [GO:0060135]; metanephric collecting duct development [GO:0072205]; monosaccharide metabolic process [GO:0005996]; negative regulation of apoptotic process [GO:0043066]; norepinephrine metabolic process [GO:0042415]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of urine volume [GO:0035809]; renal water homeostasis [GO:0003091]; response to thyroid hormone [GO:0097066]; retinoid metabolic process [GO:0001523]; stress-activated protein kinase signaling cascade [GO:0031098]; tissue homeostasis [GO:0001894]	aldose reductase (NADPH) activity [GO:0004032]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; allyl-alcohol dehydrogenase activity [GO:0047655]; aryl-alcohol dehydrogenase (NADP+) activity [GO:0047681]; cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity [GO:0018505]; D-xylose reductase (NADPH) activity [GO:0032866]; glyceraldehyde oxidoreductase activity [GO:0043795]; glycerol dehydrogenase (NADP+) activity [GO:0047956]; L-arabinose reductase (NADPH) activity [GO:0032867]; L-glucuronate reductase activity [GO:0047939]; prostaglandin H2 endoperoxidase reductase activity [GO:0036130]; retinal dehydrogenase (NAD+) activity [GO:0001758]	cytosol [GO:0005829]; extracellular region [GO:0005576]; mast cell granule [GO:0042629]; nucleoplasm [GO:0005654]; paranodal junction [GO:0033010]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane bounded cell projection cytoplasm [GO:0032838]; Schmidt-Lanterman incisure [GO:0043220]; Schwann cell microvillus [GO:0097454]	GO:0001523; GO:0001758; GO:0001894; GO:0002070; GO:0003091; GO:0004032; GO:0005576; GO:0005654; GO:0005829; GO:0005996; GO:0006060; GO:0006061; GO:0018505; GO:0031098; GO:0032838; GO:0032866; GO:0032867; GO:0033010; GO:0035809; GO:0036130; GO:0042415; GO:0042629; GO:0043066; GO:0043220; GO:0043795; GO:0044597; GO:0044598; GO:0046370; GO:0046427; GO:0047655; GO:0047681; GO:0047939; GO:0047956; GO:0048471; GO:0048661; GO:0052650; GO:0060135; GO:0071475; GO:0072061; GO:0072205; GO:0097066; GO:0097238; GO:0097454; GO:1901653
GN010739	GN010739.1	O02740	63.5	137	208	1103	2.93e-50	177	GUC2F_BOVIN	Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2)	Bos taurus (Bovine)	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]; visual perception [GO:0007601]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	membrane [GO:0016020]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0006182; GO:0007168; GO:0007601; GO:0016020; GO:0035556; GO:0120200
GN010740	GN010740.1	P16065	46.2	340	337	1125	9.39e-86	283	GCY_STRPU	Speract receptor (EC 4.6.1.2) (Guanylate cyclase)	Strongylocentrotus purpuratus (Purple sea urchin)	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	plasma membrane [GO:0005886]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0006182; GO:0007168; GO:0035556
GN010741	GN010741.1	P17342	24.2	351	396	541	2.96e-16	84.0	ANPRC_HUMAN	Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C)	Homo sapiens (Human)	negative regulation of cold-induced thermogenesis [GO:0120163]; osteoclast proliferation [GO:0002158]; positive regulation of relaxation of smooth muscle [GO:1901082]; positive regulation of urine volume [GO:0035810]; regulation of blood pressure [GO:0008217]; regulation of osteoblast proliferation [GO:0033688]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]	chloride ion binding [GO:0031404]; G protein-coupled peptide receptor activity [GO:0008528]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; receptor decoy activity [GO:0140319]	extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GO:0001501; GO:0002158; GO:0005886; GO:0007165; GO:0008217; GO:0008528; GO:0016941; GO:0017046; GO:0031404; GO:0032991; GO:0033688; GO:0035810; GO:0042277; GO:0042562; GO:0042803; GO:0070062; GO:0120163; GO:0140319; GO:1901082
GN010743	GN010743.1	H2A0M7	44.0	613	773	793	1.30e-120	384	PLSP_PINMG	Peroxidase-like protein	Margaritifera margaritifera (Freshwater pearl mussel)	response to oxidative stress [GO:0006979]	heme binding [GO:0020037]; peroxidase activity [GO:0004601]	extracellular region [GO:0005576]	GO:0004601; GO:0005576; GO:0006979; GO:0020037
GN010744	GN010744.1	Q86Z23	33.8	139	267	238	2.28e-11	65.5	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN010745	GN010745.1	Q6UX65	39.4	175	197	266	1.19e-30	115	DRAM2_HUMAN	DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77)	Homo sapiens (Human)	photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601]		apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; photoreceptor inner segment [GO:0001917]	GO:0001917; GO:0005737; GO:0005764; GO:0005765; GO:0005794; GO:0007601; GO:0010506; GO:0016324; GO:0045494
GN010748	GN010748.1	Q498J9	44.2	172	453	233	4.36e-43	154	MBLC1_XENLA	Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1)	Xenopus laevis (African clawed frog)	histone mRNA metabolic process [GO:0008334]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0008334; GO:0046872; GO:1900087
GN010749	GN010749.1	Q17RS7	45.3	464	1002	908	5.21e-119	389	GEN_HUMAN	Flap endonuclease GEN homolog 1 (EC 3.1.-.-)	Homo sapiens (Human)	double-strand break repair via homologous recombination [GO:0000724]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of centrosome duplication [GO:0010824]; replication fork processing [GO:0031297]; resolution of DNA recombination intermediates [GO:0071139]; resolution of mitotic recombination intermediates [GO:0071140]	5'-flap endonuclease activity [GO:0017108]; crossover junction DNA endonuclease activity [GO:0008821]; four-way junction DNA binding [GO:0000400]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]	centrosome [GO:0005813]; nucleoplasm [GO:0005654]	GO:0000287; GO:0000400; GO:0000724; GO:0005654; GO:0005813; GO:0008821; GO:0010824; GO:0017108; GO:0031297; GO:0042803; GO:0071139; GO:0071140; GO:0090267
GN010750	GN010750.1	Q9UIG0	35.3	1390	1374	1483	2.52e-207	650	BAZ1B_HUMAN	Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; negative regulation of mitotic chromosome condensation [GO:1905213]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; post-translational protein modification [GO:0043687]; regulation of transcription by RNA polymerase II [GO:0006357]	histone binding [GO:0042393]; histone H2AXY142 kinase activity [GO:0140801]; histone kinase activity [GO:0035173]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; zinc ion binding [GO:0008270]	B-WICH complex [GO:0110016]; condensed chromosome [GO:0000793]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; WICH complex [GO:0090535]	GO:0000793; GO:0004713; GO:0004715; GO:0005634; GO:0005654; GO:0005721; GO:0005730; GO:0006338; GO:0006357; GO:0006974; GO:0008270; GO:0035173; GO:0042393; GO:0043687; GO:0045943; GO:0045944; GO:0045945; GO:0090535; GO:0110016; GO:0140801; GO:1905213
GN010751	GN010751.1	A0A2B4RNI3	32.4	188	731	688	9.55e-25	113	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN010755	GN010755.1	P19468	61.4	617	664	637	8.76e-264	742	GSH1_RAT	Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase)	Rattus norvegicus (Rat)	blood vessel diameter maintenance [GO:0097746]; cell redox homeostasis [GO:0045454]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to insulin stimulus [GO:0032869]; cellular response to mechanical stimulus [GO:0071260]; cellular response to thyroxine stimulus [GO:0097069]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione metabolic process [GO:0006749]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of hepatic stellate cell activation [GO:2000490]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to arsenic-containing substance [GO:0046685]; response to auditory stimulus [GO:0010996]; response to cadmium ion [GO:0046686]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to human chorionic gonadotropin [GO:0044752]; response to interleukin-1 [GO:0070555]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]	ADP binding [GO:0043531]; glutamate binding [GO:0016595]; glutamate-cysteine ligase activity [GO:0004357]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; glutamate-cysteine ligase complex [GO:0017109]	GO:0000287; GO:0004357; GO:0005829; GO:0006536; GO:0006749; GO:0006750; GO:0006979; GO:0007584; GO:0009408; GO:0009410; GO:0009725; GO:0010996; GO:0014823; GO:0016595; GO:0017109; GO:0019852; GO:0031397; GO:0032436; GO:0032869; GO:0035729; GO:0043066; GO:0043524; GO:0043531; GO:0044344; GO:0044752; GO:0045454; GO:0045892; GO:0046685; GO:0046686; GO:0051409; GO:0051900; GO:0070555; GO:0071260; GO:0071333; GO:0071372; GO:0097069; GO:0097746; GO:1901029; GO:2000490; GO:2001237
GN010760	GN010760.1	P11230	25.2	314	444	501	4.00e-23	105	ACHB_HUMAN	Acetylcholine receptor subunit beta	Homo sapiens (Human)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; muscle cell development [GO:0055001]; muscle contraction [GO:0006936]; nervous system process [GO:0050877]; neuromuscular synaptic transmission [GO:0007274]; postsynaptic membrane organization [GO:0001941]; regulation of membrane potential [GO:0042391]; signal transduction [GO:0007165]; skeletal muscle contraction [GO:0003009]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]; ligand-gated monoatomic ion channel activity [GO:0015276]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]	GO:0001941; GO:0003009; GO:0004888; GO:0005886; GO:0005892; GO:0006812; GO:0006816; GO:0006936; GO:0007165; GO:0007271; GO:0007274; GO:0015267; GO:0015276; GO:0022848; GO:0030594; GO:0031594; GO:0034220; GO:0035095; GO:0042166; GO:0042391; GO:0043005; GO:0045202; GO:0050877; GO:0051899; GO:0055001; GO:0095500; GO:0099634; GO:1904315
GN010761	GN010761.1	Q96LR7	33.3	105	157	162	3.64e-15	71.6	CMIP5_HUMAN	Ciliary microtubule inner protein 5	Homo sapiens (Human)			cilium [GO:0005929]	GO:0005929
GN010762	GN010762.1	Q0VC00	50.4	375	395	411	5.13e-132	387	ABHD3_BOVIN	Phospholipase ABHD3 (EC 3.1.1.32) (EC 3.1.1.4) (Abhydrolase domain-containing protein 3)	Bos taurus (Bovine)	medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793]; phosphatidylcholine metabolic process [GO:0046470]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; A2-type glycerophospholipase activity [GO:0004623]; acetylesterase activity [GO:0008126]; glycerophospholipid phospholipase A1 activity [GO:0008970]; monoacylglycerol lipase activity [GO:0047372]	membrane [GO:0016020]	GO:0003847; GO:0004623; GO:0008126; GO:0008970; GO:0016020; GO:0046470; GO:0047372; GO:0051792; GO:0051793
GN010763	GN010763.1	O93310	64.2	229	239	629	2.00e-94	292	RAD21_XENLA	Double-strand-break repair protein rad21 homolog (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product)]	Xenopus laevis (African clawed frog)	protein localization to chromatin [GO:0071168]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; sister chromatid cohesion [GO:0007062]	chromatin binding [GO:0003682]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; spindle pole [GO:0000922]	GO:0000775; GO:0000922; GO:0003682; GO:0005634; GO:0005694; GO:0005829; GO:0007062; GO:0008278; GO:0016363; GO:0071168; GO:1990414
GN010764	GN010764.1	Q3SWX9	39.0	367	360	630	4.29e-45	166	RAD21_BOVIN	Double-strand-break repair protein rad21 homolog [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product)]	Bos taurus (Bovine)	negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; positive regulation of sister chromatid cohesion [GO:0045876]; protein localization to chromatin [GO:0071168]; regulation of transcription by RNA polymerase II [GO:0006357]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; sister chromatid cohesion [GO:0007062]	chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; meiotic cohesin complex [GO:0030893]; mitotic cohesin complex [GO:0030892]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	GO:0000775; GO:0000785; GO:0000794; GO:0000922; GO:0000987; GO:0003682; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0006357; GO:0007062; GO:0010972; GO:0016363; GO:0030892; GO:0030893; GO:0045841; GO:0045876; GO:0071168; GO:1990414
GN010767	GN010767.1	Q91880	81.0	457	620	501	9.86e-278	770	SUH_XENLA	Suppressor of hairless protein homolog (X-Su(H))	Xenopus laevis (African clawed frog)	animal organ development [GO:0048513]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	cytoplasm [GO:0005737]; MAML1-RBP-Jkappa- ICN1 complex [GO:0002193]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000978; GO:0000981; GO:0001228; GO:0002193; GO:0005634; GO:0005667; GO:0005737; GO:0007219; GO:0007221; GO:0043565; GO:0045944; GO:0048513
GN010770	GN010770.1	Q17895	62.0	50	465	249	1.79e-10	64.7	MNM2_CAEEL	Zinc finger protein mnm-2	Caenorhabditis elegans	positive regulation of axon guidance [GO:1902669]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0003700; GO:0005634; GO:0006357; GO:1902669
GN010772	GN010772.1	E7F5Q0	25.7	296	399	1290	1.48e-18	91.7	CAHD1_DANRE	VWFA and cache domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	cartilage morphogenesis [GO:0060536]	voltage-gated calcium channel activity [GO:0005245]	voltage-gated calcium channel complex [GO:0005891]	GO:0005245; GO:0005891; GO:0060536
GN010777	GN010777.1	E7F5Q0	26.6	998	1051	1290	4.85e-83	298	CAHD1_DANRE	VWFA and cache domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	cartilage morphogenesis [GO:0060536]	voltage-gated calcium channel activity [GO:0005245]	voltage-gated calcium channel complex [GO:0005891]	GO:0005245; GO:0005891; GO:0060536
GN010778	GN010778.1	Q3UZZ6	33.9	221	281	295	2.31e-29	115	ST1D1_MOUSE	Sulfotransferase 1 family member D1 (ST1D1) (EC 2.8.2.-) (Amine N-sulfotransferase) (SULT-N) (Dopamine sulfotransferase Sult1d1) (Tyrosine-ester sulfotransferase)	Mus musculus (Mouse)	sulfate assimilation [GO:0000103]; sulfation [GO:0051923]	aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]	GO:0000103; GO:0004062; GO:0005737; GO:0008146; GO:0051923
GN010779	GN010779.1	P19217	28.8	278	310	295	5.38e-34	129	ST1E1_BOVIN	Sulfotransferase 1E1 (ST1E1) (EC 2.8.2.4) (Estrogen sulfotransferase) (Sulfotransferase, estrogen-preferring)	Bos taurus (Bovine)	estrogen metabolic process [GO:0008210]; sulfation [GO:0051923]	aryl sulfotransferase activity [GO:0004062]; estrone sulfotransferase activity [GO:0004304]; steroid sulfotransferase activity [GO:0050294]	cytosol [GO:0005829]	GO:0004062; GO:0004304; GO:0005829; GO:0008210; GO:0050294; GO:0051923
GN010787	GN010787.1	Q9FT72	28.0	354	383	713	9.97e-30	124	RQL3_ARATH	ATP-dependent DNA helicase Q-like 3 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ3) (RecQ-like protein 3) (AtRecQ3) (AtRecQl3)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004386; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006310; GO:0009378; GO:0016887; GO:0043138; GO:1990814
GN010792	GN010792.1	H2A0L1	35.5	242	327	456	5.46e-35	135	TYRO2_PINMG	Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2)	Margaritifera margaritifera (Freshwater pearl mussel)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN010795	GN010795.1	H2A0L1	39.7	116	569	456	1.48e-13	76.6	TYRO2_PINMG	Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2)	Margaritifera margaritifera (Freshwater pearl mussel)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN010796	GN010796.1	Q2KII4	96.3	109	156	112	1.37e-75	223	ELOC_BOVIN	Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1)	Bos taurus (Bovine)	protein ubiquitination [GO:0016567]; target-directed miRNA degradation [GO:0140958]; transcription initiation at RNA polymerase II promoter [GO:0006367]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	protein-macromolecule adaptor activity [GO:0030674]; transcription corepressor binding [GO:0001222]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; elongin complex [GO:0070449]; nucleus [GO:0005634]	GO:0001222; GO:0005634; GO:0005737; GO:0006367; GO:0006511; GO:0016567; GO:0030674; GO:0031462; GO:0031466; GO:0070449; GO:0140627; GO:0140958
GN010797	GN010797.1	Q800B9	27.7	202	321	401	1.62e-10	65.1	NOD3B_XENTR	Nodal homolog 3-B (Nodal-related protein 3-B) (Xtnr3-B)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		growth factor activity [GO:0008083]	extracellular region [GO:0005576]	GO:0005576; GO:0008083
GN010798	GN010798.1	Q6DCY9	27.6	606	611	597	2.65e-64	225	HAUS3_XENLA	HAUS augmin-like complex subunit 3	Xenopus laevis (African clawed frog)	centrosome cycle [GO:0007098]; microtubule organizing center organization [GO:0031023]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]		centrosome [GO:0005813]; HAUS complex [GO:0070652]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; mitotic spindle microtubule [GO:1990498]	GO:0005813; GO:0005815; GO:0007098; GO:0010968; GO:0031023; GO:0051225; GO:0070652; GO:0072686; GO:1990498
GN010804	GN010804.1	Q99M80	29.6	186	372	1454	2.05e-11	69.3	PTPRT_MOUSE	Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho)	Mus musculus (Mouse)	cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to interleukin-6 [GO:0071354]; homophilic cell-cell adhesion [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; regulation of synapse organization [GO:0050807]; signal transduction [GO:0007165]	alpha-actinin binding [GO:0051393]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine phosphatase activity [GO:0004725]; STAT family protein binding [GO:0097677]; thiolester hydrolase activity [GO:0016790]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	GO:0004725; GO:0005001; GO:0005886; GO:0006470; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016790; GO:0019903; GO:0030336; GO:0031175; GO:0042803; GO:0045294; GO:0045295; GO:0045296; GO:0050807; GO:0051393; GO:0070097; GO:0071354; GO:0097677; GO:0098839; GO:0098978; GO:1904893
GN010805	GN010805.1	P23469	29.7	451	451	700	9.14e-46	172	PTPRE_HUMAN	Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)	Homo sapiens (Human)	negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; signal transduction [GO:0007165]	identical protein binding [GO:0042802]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0004725; GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007165; GO:0033003; GO:0042802; GO:0046627
GN010808	GN010808.1	P9WEL6	24.6	276	372	308	5.63e-22	98.2	AVAO_ASPVE	Ava biosynthesis cluster protein O	Aspergillus versicolor				
GN010810	GN010810.1	Q9DB77	30.4	467	478	453	1.43e-56	197	QCR2_MOUSE	Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2)	Mus musculus (Mouse)	cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; proteolysis [GO:0006508]; response to xenobiotic stimulus [GO:0009410]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; protein-containing complex binding [GO:0044877]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; nucleoplasm [GO:0005654]; respiratory chain complex III [GO:0045275]	GO:0004222; GO:0005654; GO:0005739; GO:0005743; GO:0006122; GO:0006508; GO:0009410; GO:0043209; GO:0044877; GO:0045275; GO:0045333; GO:0046872
GN010812	GN010812.1	Q5VYX0	47.2	267	278	342	9.11e-85	260	RNLS_HUMAN	Renalase (EC 1.6.3.5) (Monoamine oxidase-C) (MAO-C)	Homo sapiens (Human)	negative regulation of blood pressure [GO:0045776]; negative regulation of heart rate [GO:0010459]; response to catecholamine [GO:0071869]; response to epinephrine [GO:0071871]; response to ischemia [GO:0002931]; response to salt [GO:1902074]	epinephrine binding [GO:0051379]; monoamine oxidase activity [GO:0097621]; NADH binding [GO:0070404]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]	extracellular region [GO:0005576]	GO:0002931; GO:0005576; GO:0010459; GO:0016651; GO:0045776; GO:0051379; GO:0070404; GO:0071869; GO:0071871; GO:0097621; GO:1902074
GN010818	GN010818.1	O75293	31.8	107	165	160	2.76e-11	61.6	GA45B_HUMAN	Growth arrest and DNA damage-inducible protein GADD45 beta (Myeloid differentiation primary response protein MyD118) (Negative growth regulatory protein MyD118)	Homo sapiens (Human)	positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of cell cycle [GO:0051726]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0043065; GO:0046330; GO:0051726; GO:1900745
GN010819	GN010819.1	A3KPQ7	27.1	1099	1072	1378	5.56e-99	345	CEIP2_DANRE	Cell surface hyaluronidase (EC 3.2.1.35) (Cell migration-inducing hyaluronidase 2) (Protein frozen ventricle) (Protein wickham) (Transmembrane protein 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	atrioventricular valve formation [GO:0003190]; cardiac muscle tissue morphogenesis [GO:0055008]; cell migration involved in heart formation [GO:0060974]; cell migration to the midline involved in heart development [GO:0003318]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion development [GO:0003197]; heart looping [GO:0001947]; hyaluronan catabolic process [GO:0030214]; muscle attachment [GO:0016203]; muscle tissue morphogenesis [GO:0060415]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; regulation of sprouting angiogenesis [GO:1903670]; regulation of Wnt signaling pathway [GO:0030111]	calcium ion binding [GO:0005509]; hyalurononglucosaminidase activity [GO:0004415]	plasma membrane [GO:0005886]	GO:0001947; GO:0003143; GO:0003190; GO:0003197; GO:0003318; GO:0004415; GO:0005509; GO:0005886; GO:0016203; GO:0030111; GO:0030214; GO:0055008; GO:0060415; GO:0060974; GO:1900748; GO:1901203; GO:1903670
GN010823	GN010823.1	Q0VAA2	34.0	106	507	488	5.89e-09	62.0	LR74A_HUMAN	Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74)	Homo sapiens (Human)				
GN010824	GN010824.1	Q5BKU9	44.8	67	132	147	1.16e-12	63.9	OXLD1_HUMAN	Oxidoreductase-like domain-containing protein 1	Homo sapiens (Human)			mitochondrion [GO:0005739]	GO:0005739
GN010825	GN010825.1	Q8R0K4	28.6	245	275	290	9.89e-09	58.5	CC137_MOUSE	Coiled-coil domain-containing protein 137	Mus musculus (Mouse)			chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005694; GO:0005730
GN010830	GN010830.1	Q1RMM0	26.4	208	206	394	6.73e-09	58.2	THAP5_BOVIN	THAP domain-containing protein 5	Bos taurus (Bovine)	negative regulation of cell cycle [GO:0045786]		nucleus [GO:0005634]	GO:0005634; GO:0045786
GN010860	GN010860.1	P23469	32.0	594	1083	700	5.95e-73	259	PTPRE_HUMAN	Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)	Homo sapiens (Human)	negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; signal transduction [GO:0007165]	identical protein binding [GO:0042802]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0004725; GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007165; GO:0033003; GO:0042802; GO:0046627
GN010861	GN010861.1	P18433	30.9	640	991	802	1.80e-74	265	PTPRA_HUMAN	Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)	Homo sapiens (Human)	integrin-mediated signaling pathway [GO:0007229]; regulation of focal adhesion assembly [GO:0051893]; signal transduction [GO:0007165]	protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004725; GO:0005001; GO:0005886; GO:0005925; GO:0007165; GO:0007229; GO:0016020; GO:0043235; GO:0051893; GO:0070062
GN010865	GN010865.1	P18433	30.6	640	748	802	2.56e-76	265	PTPRA_HUMAN	Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)	Homo sapiens (Human)	integrin-mediated signaling pathway [GO:0007229]; regulation of focal adhesion assembly [GO:0051893]; signal transduction [GO:0007165]	protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004725; GO:0005001; GO:0005886; GO:0005925; GO:0007165; GO:0007229; GO:0016020; GO:0043235; GO:0051893; GO:0070062
GN010867	GN010867.1	Q1MTN8	32.3	294	386	336	9.06e-30	120	ACL4_SCHPO	Probable assembly chaperone of rpl4	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	cytosolic large ribosomal subunit assembly [GO:0180023]	protein carrier activity [GO:0140597]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730; GO:0005737; GO:0140597; GO:0180023
GN010868	GN010868.1	Q90673	39.4	203	209	215	7.79e-40	138	PRLD1_CHICK	PRELI domain-containing protein 1, mitochondrial (Px19-like protein)	Gallus gallus (Chicken)	phospholipid transport [GO:0015914]	phosphatidic acid transfer activity [GO:1990050]	mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]	GO:0005739; GO:0005758; GO:0015914; GO:1990050
GN010869	GN010869.1	E9Q7P9	34.8	135	267	1308	1.43e-16	82.8	CDHR2_MOUSE	Cadherin-related family member 2	Mus musculus (Mouse)	brush border assembly [GO:1904970]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; homophilic cell-cell adhesion [GO:0007156]; intermicrovillar adhesion [GO:0090675]; negative regulation of cell growth involved in contact inhibition [GO:0060243]; regulation of microvillus length [GO:0032532]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005902; GO:0005903; GO:0007155; GO:0007156; GO:0016324; GO:0030855; GO:0031526; GO:0031528; GO:0032532; GO:0044331; GO:0050839; GO:0060243; GO:0070161; GO:0090675; GO:1904970
GN010870	GN010870.1	Q9VGG5	32.0	194	248	1975	1.14e-22	100	CAD87_DROME	Cadherin-87A	Drosophila melanogaster (Fruit fly)	calcium-dependent cell-cell adhesion [GO:0016339]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0007155; GO:0007156; GO:0016339; GO:0044331; GO:0050839
GN010875	GN010875.1	P30122	33.1	408	389	597	9.20e-57	198	CEL_BOVIN	Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (EC 3.1.1.6) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase)	Bos taurus (Bovine)	ceramide catabolic process [GO:0046514]; pancreatic juice secretion [GO:0030157]	acetylesterase activity [GO:0008126]; FAHFA hydrolase activity [GO:0120573]; retinyl-palmitate esterase activity [GO:0050253]; sterol ester esterase activity [GO:0004771]; triacylglycerol lipase activity [GO:0004806]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	GO:0004771; GO:0004806; GO:0005576; GO:0005737; GO:0008126; GO:0030157; GO:0046514; GO:0050253; GO:0120573
GN010876	GN010876.1	Q63108	34.8	552	561	561	5.28e-87	283	EST1E_RAT	Carboxylesterase 1E (EC 3.1.1.1) (Carboxyesterase ES-3) (ES-HTEL) (Egasyn) (Liver carboxylesterase 3) (pI 5.5 esterase)	Rattus norvegicus (Rat)	retinoid metabolic process [GO:0001523]; short-chain fatty acid catabolic process [GO:0019626]	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; retinyl-palmitate esterase activity [GO:0050253]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]	GO:0001523; GO:0005783; GO:0005788; GO:0005811; GO:0019626; GO:0043231; GO:0047376; GO:0050253; GO:0052689; GO:0106435
GN010877	GN010877.1	G3V7J5	34.8	557	1177	567	1.25e-84	290	EST2E_RAT	Pyrethroid hydrolase Ces2e (EC 3.1.1.88) (Carboxylic ester hydrolase) (EC 3.1.1.-)	Rattus norvegicus (Rat)	retinoid metabolic process [GO:0001523]	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; carboxylesterase activity [GO:0106435]; retinyl-palmitate esterase activity [GO:0050253]; trans-permethrin hydrolase activity [GO:0102209]	intracellular membrane-bounded organelle [GO:0043231]	GO:0001523; GO:0043231; GO:0047376; GO:0050253; GO:0102209; GO:0106435
GN010878	GN010878.1	Q04791	31.9	527	590	557	3.84e-75	252	SASB_ANAPL	Fatty acyl-CoA hydrolase precursor, medium chain (EC 3.1.2.-) (Thioesterase B)	Anas platyrhynchos (Mallard) (Anas boschas)				
GN010879	GN010879.1	Q9GZU0	62.1	190	203	229	5.15e-88	261	CF062_HUMAN	Uncharacterized protein C6orf62 (HBV X-transactivated gene 12 protein) (HBV XAg-transactivated protein 12)	Homo sapiens (Human)				
GN010882	GN010882.1	O54753	43.5	262	386	317	2.49e-64	211	H17B6_RAT	17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.239) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase)	Rattus norvegicus (Rat)	androgen metabolic process [GO:0008209]; brexanolone catabolic process [GO:0062175]; estrogen biosynthetic process [GO:0006703]; retinol metabolic process [GO:0042572]	5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity [GO:0047024]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity [GO:0047044]; androsterone dehydrogenase [NAD(P)+] activity [GO:0047023]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; testosterone dehydrogenase (NADP+) activity [GO:0047045]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0004303; GO:0004745; GO:0005783; GO:0005789; GO:0006703; GO:0008209; GO:0042572; GO:0047023; GO:0047024; GO:0047035; GO:0047044; GO:0047045; GO:0062175
GN010883	GN010883.1	Q6P7A9	49.2	886	988	953	4.39e-304	869	LYAG_RAT	Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase)	Rattus norvegicus (Rat)	aorta development [GO:0035904]; diaphragm contraction [GO:0002086]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]; glycophagy [GO:0061723]; heart morphogenesis [GO:0003007]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; muscle cell cellular homeostasis [GO:0046716]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; regulation of the force of heart contraction [GO:0002026]; striated muscle contraction [GO:0006941]; tissue development [GO:0009888]	alpha-1,4-glucosidase activity [GO:0004558]; alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246]; glucan 1,6-alpha-glucosidase activity [GO:0043896]	autolysosome lumen [GO:0120282]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]	GO:0002026; GO:0002086; GO:0003007; GO:0004558; GO:0005764; GO:0005765; GO:0005977; GO:0005980; GO:0006941; GO:0007040; GO:0007626; GO:0009888; GO:0016020; GO:0030246; GO:0035904; GO:0043896; GO:0046716; GO:0050884; GO:0050885; GO:0061723; GO:0090599; GO:0120282
GN010884	GN010884.1	Q16982	53.3	184	191	193	7.06e-65	201	NECX_APLCA	Neurocalcin	Aplysia californica (California sea hare)		calcium ion binding [GO:0005509]		GO:0005509
GN010887	GN010887.1	Q8IY84	66.7	363	418	436	3.83e-171	489	NIM1_HUMAN	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase)	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]		GO:0000287; GO:0004674; GO:0005524; GO:0035556; GO:0106310
GN010888	GN010888.1	Q96EQ0	45.0	329	354	304	1.94e-45	160	SGTB_HUMAN	Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2)	Homo sapiens (Human)	post-translational protein targeting to endoplasmic reticulum membrane [GO:0006620]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]	membrane [GO:0016020]; TRC complex [GO:0072380]	GO:0006620; GO:0016020; GO:0030544; GO:0042802; GO:0051260; GO:0051291; GO:0060090; GO:0072380
GN010890	GN010890.1	P42325	53.5	114	123	190	4.43e-42	140	NCAH_DROME	Neurocalcin homolog (DrosNCa)	Drosophila melanogaster (Fruit fly)	negative regulation of neuronal signal transduction [GO:1902848]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; regulation of signal transduction [GO:0009966]	calcium ion binding [GO:0005509]		GO:0005509; GO:0009966; GO:0045938; GO:1902848
GN010891	GN010891.1	Q32NG5	41.2	553	964	588	1.57e-124	393	GTR12_XENLA	Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12)	Xenopus laevis (African clawed frog)	circulatory system development [GO:0072359]; D-glucose transmembrane transport [GO:1904659]	transmembrane transporter activity [GO:0022857]	endomembrane system [GO:0012505]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0005886; GO:0012505; GO:0022857; GO:0048471; GO:0072359; GO:1904659
GN010892	GN010892.1	F1MF21	28.7	471	691	582	9.38e-30	128	PARI_BOVIN	PCNA-interacting partner (PARI) (PARP-1 binding protein) (PARP1-binding protein) (PARPBP)	Bos taurus (Bovine)	negative regulation of double-strand break repair via homologous recombination [GO:2000042]		chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005737; GO:2000042
GN010893	GN010893.1	Q9UIF7	54.1	440	459	546	3.30e-149	439	MUTYH_HUMAN	Adenine DNA glycosylase (EC 3.2.2.31) (MutY homolog) (hMYH)	Homo sapiens (Human)	base-excision repair [GO:0006284]; depurination [GO:0045007]; DNA repair [GO:0006281]; mismatch repair [GO:0006298]; negative regulation of necroptotic process [GO:0060546]	4 iron, 4 sulfur cluster binding [GO:0051539]; 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; adenine/guanine mispair binding [GO:0035485]; DNA N-glycosylase activity [GO:0019104]; MutSalpha complex binding [GO:0032407]; oxidized purine DNA binding [GO:0032357]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000701; GO:0005634; GO:0005654; GO:0005739; GO:0006281; GO:0006284; GO:0006298; GO:0019104; GO:0032357; GO:0032407; GO:0034039; GO:0035485; GO:0045007; GO:0051539; GO:0060546
GN010895	GN010895.1	P0CP40	25.4	248	446	450	6.12e-16	83.2	NUF2_CRYD1	Probable kinetochore protein NUF2	Cryptococcus deneoformans (strain JEC21 / ATCC MYA-565) (Cryptococcus neoformans var. neoformans serotype D)	attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; kinetochore organization [GO:0051383]; meiotic chromosome segregation [GO:0045132]	microtubule binding [GO:0008017]; protein-containing complex binding [GO:0044877]	Ndc80 complex [GO:0031262]; nucleus [GO:0005634]	GO:0005634; GO:0008017; GO:0031262; GO:0044877; GO:0045132; GO:0051315; GO:0051383
GN010896	GN010896.1	Q0IHA2	35.6	267	262	265	1.87e-43	151	ELP6_XENLA	Elongator complex protein 6 (Protein TMEM103)	Xenopus laevis (African clawed frog)	positive regulation of cell migration [GO:0030335]; tRNA wobble uridine modification [GO:0002098]		cytoplasm [GO:0005737]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634]	GO:0002098; GO:0005634; GO:0005737; GO:0030335; GO:0033588
GN010898	GN010898.1	P42325	49.2	183	186	190	7.20e-53	170	NCAH_DROME	Neurocalcin homolog (DrosNCa)	Drosophila melanogaster (Fruit fly)	negative regulation of neuronal signal transduction [GO:1902848]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; regulation of signal transduction [GO:0009966]	calcium ion binding [GO:0005509]		GO:0005509; GO:0009966; GO:0045938; GO:1902848
GN010899	GN010899.1	Q96EP9	25.2	282	562	437	1.79e-18	91.7	NTCP4_HUMAN	Putative sodium/bile acid cotransporter 4 (Na(+)/bile acid cotransporter 4) (Solute carrier family 10 member 4)	Homo sapiens (Human)	bile acid and bile salt transport [GO:0015721]		plasma membrane [GO:0005886]	GO:0005886; GO:0015721
GN010900	GN010900.1	Q0V9D9	32.1	224	234	231	3.86e-21	91.3	COA7_XENTR	Cytochrome c oxidase assembly factor 7 (Beta-lactamase hcp-like protein SELRC1) (Sel1 repeat-containing protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	respiratory chain complex IV assembly [GO:0008535]	protein-disulfide reductase activity [GO:0015035]	mitochondrial intermembrane space [GO:0005758]	GO:0005758; GO:0008535; GO:0015035
GN010901	GN010901.1	Q96MR6	57.7	1224	1213	1250	0.0	1045	CFA57_HUMAN	Cilia- and flagella-associated protein 57 (WD repeat-containing protein 65)	Homo sapiens (Human)			axoneme [GO:0005930]; cilium [GO:0005929]; sperm flagellum [GO:0036126]	GO:0005929; GO:0005930; GO:0036126
GN010905	GN010905.1	Q9BT30	48.4	192	207	221	1.86e-55	178	ALKB7_HUMAN	RNA demethylase ALKBH7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 7) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial) (Spermatogenesis cell proliferation-related protein) (Spermatogenesis-associated protein 11) (pre-tRNA N1-methyl adenine demethylase ALKBH7) (pre-tRNA N2-dimethyl guanosine demethylase ALKBH7)	Homo sapiens (Human)	DNA damage response [GO:0006974]; fatty acid metabolic process [GO:0006631]; oxidative RNA demethylation [GO:0035513]; regulation of lipid storage [GO:0010883]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]	oxidative RNA demethylase activity [GO:0035515]; tRNA demethylase activity [GO:1990984]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0006631; GO:0006974; GO:0010883; GO:0035513; GO:0035515; GO:1902445; GO:1990984
GN010906	GN010906.1	Q24746	34.6	156	1303	747	1.26e-22	108	NEUR_DROVI	Protein neuralized	Drosophila virilis (Fruit fly)	asymmetric cell division [GO:0008356]; compound eye development [GO:0048749]; germ-line stem cell population maintenance [GO:0030718]; imaginal disc-derived wing morphogenesis [GO:0007476]; intracellular protein localization [GO:0008104]; long-term memory [GO:0007616]; mesoderm development [GO:0007498]; negative regulation of lamellocyte differentiation [GO:0035204]; nervous system development [GO:0007399]; peripheral nervous system development [GO:0007422]; positive regulation of endocytosis [GO:0045807]; positive regulation of Notch signaling pathway [GO:0045747]; protein polyubiquitination [GO:0000209]; regulation of compound eye photoreceptor development [GO:0045314]; sensory organ development [GO:0007423]; sensory organ precursor cell fate determination [GO:0016360]	phosphatidylinositol phosphate binding [GO:1901981]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	endosome [GO:0005768]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0000209; GO:0004842; GO:0005634; GO:0005768; GO:0005886; GO:0007399; GO:0007422; GO:0007423; GO:0007476; GO:0007498; GO:0007616; GO:0008104; GO:0008356; GO:0016360; GO:0030718; GO:0035204; GO:0045314; GO:0045747; GO:0045807; GO:0048471; GO:0048749; GO:0061630; GO:1901981
GN010907	GN010907.1	Q8C561	49.0	720	711	694	2.49e-224	645	LMBD2_MOUSE	G protein-coupled receptor-associated protein LMBRD2 (LMBR1 domain-containing protein 2)	Mus musculus (Mouse)	adrenergic receptor signaling pathway [GO:0071875]		membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0016020; GO:0071875
GN010908	GN010908.1	Q99PF4	31.0	1827	1880	3354	4.47e-185	626	CAD23_MOUSE	Cadherin-23 (Otocadherin)	Mus musculus (Mouse)	auditory receptor cell stereocilium organization [GO:0060088]; calcium ion transport [GO:0006816]; calcium-dependent cell-cell adhesion [GO:0016339]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cochlea development [GO:0090102]; equilibrioception [GO:0050957]; homophilic cell-cell adhesion [GO:0007156]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; neuron projection development [GO:0031175]; photoreceptor cell maintenance [GO:0045494]; regulation of cytosolic calcium ion concentration [GO:0051480]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]	apical part of cell [GO:0045177]; catenin complex [GO:0016342]; centrosome [GO:0005813]; cochlear hair cell ribbon synapse [GO:0098683]; kinocilium [GO:0060091]; photoreceptor inner segment [GO:0001917]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; synapse [GO:0045202]	GO:0001917; GO:0005509; GO:0005813; GO:0005886; GO:0006816; GO:0007155; GO:0007156; GO:0007605; GO:0007626; GO:0008013; GO:0016339; GO:0016342; GO:0016477; GO:0031175; GO:0032420; GO:0032426; GO:0042472; GO:0042491; GO:0042802; GO:0045177; GO:0045202; GO:0045296; GO:0045494; GO:0048839; GO:0050953; GO:0050957; GO:0051480; GO:0060088; GO:0060091; GO:0060122; GO:0090102; GO:0098609; GO:0098683; GO:0098684
GN010909	GN010909.1	Q8N3C7	40.3	690	628	705	2.25e-158	474	CLIP4_HUMAN	CAP-Gly domain-containing linker protein 4 (Restin-like protein 2)	Homo sapiens (Human)	cytoplasmic microtubule organization [GO:0031122]	microtubule plus-end binding [GO:0051010]	cell cortex [GO:0005938]; microtubule plus-end [GO:0035371]; nucleus [GO:0005634]	GO:0005634; GO:0005938; GO:0031122; GO:0035371; GO:0051010
GN010910	GN010910.1	Q16982	89.3	187	191	193	5.33e-125	353	NECX_APLCA	Neurocalcin	Aplysia californica (California sea hare)		calcium ion binding [GO:0005509]		GO:0005509
GN010912	GN010912.1	E9PY46	52.3	1486	1480	1464	0.0	1529	IF140_MOUSE	Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2)	Mus musculus (Mouse)	cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; heart development [GO:0007507]; intraciliary anterograde transport [GO:0035720]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; limb morphogenesis [GO:0035108]; neural tube patterning [GO:0021532]; non-motile cilium assembly [GO:1905515]; photoreceptor cell outer segment organization [GO:0035845]; protein localization to cilium [GO:0061512]; protein localization to non-motile cilium [GO:0097499]; regulation of cilium assembly [GO:1902017]; regulation of smoothened signaling pathway [GO:0008589]	protein carrier activity [GO:0140597]	axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]; mitochondrion [GO:0005739]; non-motile cilium [GO:0097730]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]	GO:0001750; GO:0005654; GO:0005739; GO:0005813; GO:0005814; GO:0005929; GO:0005930; GO:0007368; GO:0007507; GO:0008589; GO:0021532; GO:0030991; GO:0031076; GO:0032391; GO:0035108; GO:0035720; GO:0035721; GO:0035845; GO:0036064; GO:0042073; GO:0042733; GO:0048701; GO:0060271; GO:0061512; GO:0097499; GO:0097730; GO:0140597; GO:1902017; GO:1905515; GO:1990403
GN010916	GN010916.1	Q6Q0C0	53.6	612	623	670	4.41e-128	395	TRAF7_HUMAN	E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)	Homo sapiens (Human)	apoptotic process [GO:0006915]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein K29-linked ubiquitination [GO:0035519]; protein ubiquitination [GO:0016567]; regulation of ERK1 and ERK2 cascade [GO:0070372]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0004842; GO:0005634; GO:0005737; GO:0006915; GO:0008270; GO:0016567; GO:0031410; GO:0035519; GO:0043410; GO:0043525; GO:0061630; GO:0070372; GO:2000060; GO:2001235
GN010917	GN010917.1	Q9FPH3	49.3	205	235	355	1.94e-63	204	THA2_ARATH	Probable low-specificity L-threonine aldolase 2 (EC 4.1.2.48) (Threonine aldolase 2)	Arabidopsis thaliana (Mouse-ear cress)	glycine biosynthetic process [GO:0006545]; L-threonine catabolic process [GO:0006567]	L-allo-threonine aldolase activity [GO:0008732]; threonine aldolase activity [GO:0004793]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004793; GO:0005634; GO:0005829; GO:0006545; GO:0006567; GO:0008732
GN010918	GN010918.1	Q7TT16	31.0	377	318	396	4.08e-56	189	IPMK_MOUSE	Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)	Mus musculus (Mouse)	inositol phosphate biosynthetic process [GO:0032958]; inositol trisphosphate metabolic process [GO:0032957]; necroptotic process [GO:0070266]; neural tube formation [GO:0001841]; phosphatidylinositol metabolic process [GO:0046488]	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; flavonoid binding [GO:0097243]; inositol-1,3,4,5-tetrakisphosphate 6-kinase activity [GO:0000825]; inositol-1,3,4,6-tetrakisphosphate 5-kinase activity [GO:0047326]; inositol-1,4,5,6-tetrakisphosphate 3-kinase activity [GO:0000824]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]; inositol-1,4,5-trisphosphate 6-kinase activity [GO:0000823]	ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000823; GO:0000824; GO:0000825; GO:0001841; GO:0005634; GO:0005654; GO:0005737; GO:0008440; GO:0032957; GO:0032958; GO:0036064; GO:0046488; GO:0046934; GO:0047326; GO:0070266; GO:0097243
GN010919	GN010919.1	P41827	76.0	637	634	640	0.0	963	HSP74_ANOAL	Heat shock protein 70 B2	Anopheles albimanus (New world malaria mosquito)	response to stress [GO:0006950]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]		GO:0005524; GO:0006950; GO:0016887
GN010920	GN010920.1	P41827	76.3	637	634	640	0.0	967	HSP74_ANOAL	Heat shock protein 70 B2	Anopheles albimanus (New world malaria mosquito)	response to stress [GO:0006950]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]		GO:0005524; GO:0006950; GO:0016887
GN010921	GN010921.1	P41827	76.1	637	634	640	0.0	962	HSP74_ANOAL	Heat shock protein 70 B2	Anopheles albimanus (New world malaria mosquito)	response to stress [GO:0006950]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]		GO:0005524; GO:0006950; GO:0016887
GN010925	GN010925.1	Q9NZJ4	24.2	4747	4094	4579	1.72e-275	940	SACS_HUMAN	Sacsin (DnaJ homolog subfamily C member 29)	Homo sapiens (Human)	negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0070852; GO:0090084
GN010926	GN010926.1	Q9NZJ4	25.3	4535	4147	4579	9.26e-300	1015	SACS_HUMAN	Sacsin (DnaJ homolog subfamily C member 29)	Homo sapiens (Human)	negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0070852; GO:0090084
GN010927	GN010927.1	Q14CX7	37.3	899	887	972	2.13e-194	585	NAA25_HUMAN	N-alpha-acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25) (p120)	Homo sapiens (Human)	cytoskeleton organization [GO:0007010]	acetyltransferase activator activity [GO:0010698]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatB complex [GO:0031416]	GO:0005737; GO:0005829; GO:0007010; GO:0010698; GO:0031416
GN010928	GN010928.1	Q6QI44	57.8	83	85	970	1.35e-23	95.9	NAA25_RAT	N-alpha-acetyltransferase 25, NatB auxiliary subunit (Liver regeneration-related protein LRRGT00164) (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25)	Rattus norvegicus (Rat)	cytoskeleton organization [GO:0007010]	acetyltransferase activator activity [GO:0010698]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatB complex [GO:0031416]	GO:0005737; GO:0005829; GO:0007010; GO:0010698; GO:0031416
GN010932	GN010932.1	Q8WXE0	42.9	224	419	1202	3.20e-20	97.1	CSKI2_HUMAN	Caskin-2 (CASK-interacting protein 2)	Homo sapiens (Human)	signal transduction [GO:0007165]		cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0007165
GN010933	GN010933.1	P82094	38.1	641	1400	1093	1.35e-74	274	TMF1_HUMAN	TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa)	Homo sapiens (Human)	androgen receptor signaling pathway [GO:0030521]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of proteasomal protein catabolic process [GO:0061136]	nuclear androgen receptor binding [GO:0050681]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]	GO:0000139; GO:0003713; GO:0005634; GO:0005783; GO:0005794; GO:0005829; GO:0030521; GO:0045944; GO:0050681; GO:0061136
GN010936	GN010936.1	Q14CX7	39.1	983	970	972	1.09e-228	676	NAA25_HUMAN	N-alpha-acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25) (p120)	Homo sapiens (Human)	cytoskeleton organization [GO:0007010]	acetyltransferase activator activity [GO:0010698]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NatB complex [GO:0031416]	GO:0005737; GO:0005829; GO:0007010; GO:0010698; GO:0031416
GN010937	GN010937.1	Q9NZJ4	26.4	4766	4454	4579	0.0	1149	SACS_HUMAN	Sacsin (DnaJ homolog subfamily C member 29)	Homo sapiens (Human)	negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0070852; GO:0090084
GN010942	GN010942.1	Q969T9	46.0	215	246	261	6.62e-38	136	WBP2_HUMAN	WW domain-binding protein 2 (WBP-2)	Homo sapiens (Human)	cellular response to estrogen stimulus [GO:0071391]; establishment of protein localization to chromatin [GO:0071169]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; response to estrogen [GO:0043627]; response to progesterone [GO:0032570]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromatin DNA binding [GO:0031490]; nuclear estrogen receptor binding [GO:0030331]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0030331; GO:0031490; GO:0032570; GO:0033148; GO:0043627; GO:0045815; GO:0045893; GO:0045944; GO:0050847; GO:0071169; GO:0071391
GN010943	GN010943.1	Q9W107	45.0	442	616	464	8.38e-132	397	SYYM_DROME	Tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Mitochondrial tyrosyl-tRNA synthetase) (Tyrosyl-tRNA synthetase) (TyrRS)	Drosophila melanogaster (Fruit fly)	mitochondrial tyrosyl-tRNA aminoacylation [GO:0070184]; tyrosyl-tRNA aminoacylation [GO:0006437]	ATP binding [GO:0005524]; RNA binding [GO:0003723]; tyrosine-tRNA ligase activity [GO:0004831]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003723; GO:0004831; GO:0005524; GO:0005739; GO:0005759; GO:0006437; GO:0070184
GN010944	GN010944.1	Q5E9Z7	48.8	168	200	398	4.51e-15	75.9	RPC4_BOVIN	DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D)	Bos taurus (Bovine)	positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; tRNA transcription by RNA polymerase III [GO:0042797]	DNA binding [GO:0003677]	RNA polymerase III complex [GO:0005666]	GO:0003677; GO:0005666; GO:0032728; GO:0042797; GO:0045089
GN010946	GN010946.1	Q10984	26.4	276	480	354	2.27e-19	92.8	FUT2_RAT	Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha 1,2-fucosyltransferase) (Alpha 1,2-fucosyltransferase B) (Alpha 1-2 fucosyltransferase) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Secretor blood group alpha-2-fucosyltransferase) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)	Rattus norvegicus (Rat)	glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation via fucose [GO:0036066]	alpha-(1,2)-fucosyltransferase activity [GO:0031127]; fucosyltransferase activity [GO:0008417]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; plasma membrane [GO:0005886]	GO:0005794; GO:0005886; GO:0008107; GO:0008417; GO:0009101; GO:0009312; GO:0031127; GO:0032580; GO:0036066
GN010951	GN010951.1	Q9UH99	30.2	440	876	717	6.40e-50	191	SUN2_HUMAN	SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2)	Homo sapiens (Human)	centrosome localization [GO:0051642]; mitotic spindle organization [GO:0007052]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nuclear migration [GO:0007097]; nuclear migration along microfilament [GO:0031022]; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration [GO:0021817]; positive regulation of cell migration [GO:0030335]	cytoskeleton-nuclear membrane anchor activity [GO:0140444]; identical protein binding [GO:0042802]; lamin binding [GO:0005521]; microtubule binding [GO:0008017]	chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; endosome membrane [GO:0010008]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]	GO:0000781; GO:0000794; GO:0005521; GO:0005635; GO:0005637; GO:0007052; GO:0007097; GO:0008017; GO:0010008; GO:0021817; GO:0030335; GO:0031022; GO:0031965; GO:0034993; GO:0042802; GO:0051642; GO:0090292; GO:0140444
GN010954	GN010954.1	Q3T106	56.5	69	416	235	1.53e-17	84.7	SRSF7_BOVIN	Serine/arginine-rich splicing factor 7 (Splicing factor, arginine/serine-rich 7)	Bos taurus (Bovine)	negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000381; GO:0003723; GO:0005634; GO:0005737; GO:0008270; GO:0048025
GN010955	GN010955.1	Q99PT1	55.3	190	200	204	8.58e-66	204	GDIR1_MOUSE	Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (GDI-1) (Rho-GDI alpha)	Mus musculus (Mouse)	cellular response to mechanical stimulus [GO:0071260]; negative regulation of cell migration [GO:0030336]; regulation of cell shape [GO:0008360]; regulation of protein localization [GO:0032880]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synaptic vesicle cycle [GO:0098693]; Rho protein signal transduction [GO:0007266]; semaphorin-plexin signaling pathway [GO:0071526]	fatty acid binding [GO:0005504]; Hsp90 protein binding [GO:0051879]; protein kinase binding [GO:0019901]; Rho GDP-dissociation inhibitor activity [GO:0005094]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; immunological synapse [GO:0001772]; membrane [GO:0016020]; nucleus [GO:0005634]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]	GO:0001772; GO:0005094; GO:0005504; GO:0005576; GO:0005634; GO:0005737; GO:0005829; GO:0007266; GO:0008360; GO:0016020; GO:0019901; GO:0030336; GO:0031267; GO:0032880; GO:0035023; GO:0045202; GO:0051879; GO:0071260; GO:0071526; GO:0098685; GO:0098693
GN010956	GN010956.1	P82861	56.1	467	483	498	5.39e-181	519	ADRO_SALFO	NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase)	Salvelinus fontinalis (Brook trout) (Salmo fontinalis)	cholesterol metabolic process [GO:0008203]	ferredoxin-NADP+ reductase activity [GO:0004324]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0004324; GO:0005739; GO:0005743; GO:0008203
GN010957	GN010957.1	Q6ZVD7	40.0	185	915	989	1.56e-33	143	STOX1_HUMAN	Storkhead-box protein 1 (Winged-helix domain-containing protein)	Homo sapiens (Human)	cellular response to nitrosative stress [GO:0071500]; inner ear development [GO:0048839]; negative regulation of gene expression [GO:0010629]; positive regulation of cyclin-dependent protein kinase activity [GO:1904031]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of gene expression [GO:0010628]; positive regulation of otic vesicle morphogenesis [GO:1904120]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of gene expression [GO:0010468]; regulation of mitochondrial DNA metabolic process [GO:1901858]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of response to oxidative stress [GO:1902882]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000977; GO:0001650; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005938; GO:0006357; GO:0010468; GO:0010628; GO:0010629; GO:0010800; GO:0010821; GO:0010971; GO:0033138; GO:0048839; GO:0051881; GO:0051897; GO:0071500; GO:1900087; GO:1901858; GO:1902882; GO:1904031; GO:1904120
GN010962	GN010962.1	P18433	31.1	570	975	802	6.78e-68	246	PTPRA_HUMAN	Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)	Homo sapiens (Human)	integrin-mediated signaling pathway [GO:0007229]; regulation of focal adhesion assembly [GO:0051893]; signal transduction [GO:0007165]	protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004725; GO:0005001; GO:0005886; GO:0005925; GO:0007165; GO:0007229; GO:0016020; GO:0043235; GO:0051893; GO:0070062
GN010964	GN010964.1	O14522	40.9	259	623	1441	3.64e-53	200	PTPRT_HUMAN	Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho)	Homo sapiens (Human)	cell adhesion [GO:0007155]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to interleukin-6 [GO:0071354]; homophilic cell-cell adhesion [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	alpha-actinin binding [GO:0051393]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine phosphatase activity [GO:0004725]; STAT family protein binding [GO:0097677]; thiolester hydrolase activity [GO:0016790]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004725; GO:0005001; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016020; GO:0016790; GO:0019903; GO:0030336; GO:0031175; GO:0042803; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097; GO:0071354; GO:0097677; GO:1904893
GN010966	GN010966.1	Q5ZLV2	82.5	160	161	161	5.20e-101	290	PPIL3_CHICK	Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3)	Gallus gallus (Chicken)	protein folding [GO:0006457]	peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	catalytic step 2 spliceosome [GO:0071013]	GO:0003755; GO:0006457; GO:0071013
GN010967	GN010967.1	P35574	50.0	1555	1560	1555	0.0	1531	GDE_RABIT	Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]	Oryctolagus cuniculus (Rabbit)	glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]	4-alpha-glucanotransferase activity [GO:0004134]; amylo-alpha-1,6-glucosidase activity [GO:0004135]	cytoplasm [GO:0005737]	GO:0004134; GO:0004135; GO:0005737; GO:0005978; GO:0005980
GN010970	GN010970.1	Q24K03	43.4	235	397	357	6.44e-58	196	THUM1_BOVIN	THUMP domain-containing protein 1	Bos taurus (Bovine)	tRNA modification [GO:0006400]	RNA binding [GO:0003723]		GO:0003723; GO:0006400
GN010971	GN010971.1	Q8WPA2	34.4	299	415	361	1.88e-42	155	AR_BOMMO	Allatostatin-A receptor (BAR)	Bombyx mori (Silk moth)		G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; neuropeptide binding [GO:0042923]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0042562; GO:0042923
GN010972	GN010972.1	O43808	52.3	306	455	307	3.96e-94	289	PM34_HUMAN	Peroxisomal membrane protein PMP34 (34 kDa peroxisomal membrane protein) (Solute carrier family 25 member 17)	Homo sapiens (Human)	ATP transport [GO:0015867]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; fatty acid transport [GO:0015908]; nucleotide transmembrane transport [GO:1901679]	adenine nucleotide transmembrane transporter activity [GO:0000295]; ADP transmembrane transporter activity [GO:0015217]; AMP transmembrane transporter activity [GO:0080122]; ATP transmembrane transporter activity [GO:0005347]; coenzyme A transmembrane transporter activity [GO:0015228]; FAD transmembrane transporter activity [GO:0015230]; FMN transmembrane transporter activity [GO:0044610]; NAD transmembrane transporter activity [GO:0051724]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0000295; GO:0001561; GO:0005347; GO:0005737; GO:0005777; GO:0005778; GO:0005829; GO:0006635; GO:0015217; GO:0015228; GO:0015230; GO:0015867; GO:0015908; GO:0016020; GO:0044610; GO:0051087; GO:0051724; GO:0080122; GO:1901679
GN010973	GN010973.1	P53395	52.4	380	408	482	2.65e-121	363	ODB2_MOUSE	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)	Mus musculus (Mouse)	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA [GO:0120552]; branched-chain amino acid catabolic process [GO:0009083]; L-isoleucine catabolic process [GO:0006550]; L-leucine catabolic process [GO:0006552]; L-valine catabolic process [GO:0006574]	dihydrolipoamide branched chain acyltransferase activity [GO:0043754]; ubiquitin protein ligase binding [GO:0031625]	branched-chain alpha-ketoacid dehydrogenase complex [GO:0160157]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0005829; GO:0006550; GO:0006552; GO:0006574; GO:0009083; GO:0015630; GO:0031625; GO:0042645; GO:0043754; GO:0120552; GO:0160157
GN010976	GN010976.1	Q2YDC9	43.3	349	341	344	3.93e-93	284	PDCD2_BOVIN	uS5 assembly chaperone PDCD2 (Programmed cell death protein 2)	Bos taurus (Bovine)	ribosomal small subunit biogenesis [GO:0042274]	protein carrier activity [GO:0140597]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730; GO:0005829; GO:0042274; GO:0140597
GN010977	GN010977.1	Q29L80	53.8	199	212	211	2.20e-68	211	PITH1_DROPS	PITH domain-containing protein GA19395	Drosophila pseudoobscura pseudoobscura (Fruit fly)	positive regulation of megakaryocyte differentiation [GO:0045654]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0045654
GN010978	GN010978.1	Q5EA80	44.9	568	571	567	5.36e-151	448	PGTA_BOVIN	Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha)	Bos taurus (Bovine)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; protein geranylgeranylation [GO:0018344]	Rab geranylgeranyltransferase activity [GO:0004663]; small GTPase binding [GO:0031267]; zinc ion binding [GO:0008270]	Rab-protein geranylgeranyltransferase complex [GO:0005968]	GO:0004663; GO:0005968; GO:0006888; GO:0008270; GO:0018344; GO:0031267
GN010979	GN010979.1	O57321	52.4	473	514	543	3.84e-154	453	EAA1_AMBTI	Excitatory amino acid transporter 1 (SEAAT1) (Sodium-dependent glutamate/aspartate transporter) (GLAST)	Ambystoma tigrinum (Eastern tiger salamander)	chloride transmembrane transport [GO:1902476]; D-aspartate import across plasma membrane [GO:0070779]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamate import across plasma membrane [GO:0098712]; potassium ion transmembrane transport [GO:0071805]	glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	plasma membrane [GO:0005886]	GO:0005314; GO:0005886; GO:0015175; GO:0015501; GO:0070779; GO:0071805; GO:0098712; GO:0140009; GO:1902476
GN010980	GN010980.1	Q95JY5	54.7	106	144	667	2.39e-30	117	SAM15_MACFA	Sterile alpha motif domain-containing protein 15 (SAM domain-containing protein 15)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)				
GN010985	GN010985.1	B3A0P8	31.8	151	1042	318	3.34e-17	87.4	SCP2_LOTGI	SCP domain-containing protein 2 (Uncharacterized shell protein 3) (LUSP-3)	Lottia gigantea (Giant owl limpet)			extracellular region [GO:0005576]	GO:0005576
GN010987	GN010987.1	Q6NRE4	56.0	75	829	876	5.06e-17	89.7	GARE1_XENLA	GRB2-associated and regulator of MAPK protein (GRB2-associated and regulator of MAPK1)	Xenopus laevis (African clawed frog)	cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]	proline-rich region binding [GO:0070064]		GO:0007173; GO:0008284; GO:0070064; GO:0070374; GO:0071364
GN010991	GN010991.1	Q55G87	27.5	178	180	180	1.50e-18	81.6	CANB1_DICDI	Calcineurin subunit B type 1 (Calcineurin regulatory subunit 1) (Protein phosphatase 2B regulatory subunit 1)	Dictyostelium discoideum (Social amoeba)	calcineurin-mediated signaling [GO:0097720]; positive regulation of sorocarp stalk cell differentiation [GO:0031287]; response to cation stress [GO:0043157]	calcium ion binding [GO:0005509]; calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; phosphatase binding [GO:0019902]; protein phosphatase binding [GO:0019903]	calcineurin complex [GO:0005955]	GO:0005509; GO:0005955; GO:0008597; GO:0019902; GO:0019903; GO:0031287; GO:0043157; GO:0097720
GN010992	GN010992.1	Q32L77	40.5	215	215	232	6.76e-41	142	CFA95_BOVIN	Cilia- and flagella-associated protein 95	Bos taurus (Bovine)	flagellated sperm motility [GO:0030317]		axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]	GO:0005737; GO:0005879; GO:0005886; GO:0030317; GO:0036126; GO:0160111
GN010993	GN010993.1	Q00174	38.7	3792	3662	3712	0.0	1765	LAMA_DROME	Laminin subunit alpha (Laminin A chain)	Drosophila melanogaster (Fruit fly)	animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; cell adhesion mediated by integrin [GO:0033627]; dorsal trunk growth, open tracheal system [GO:0035001]; heart development [GO:0007507]; melanotic encapsulation of foreign target [GO:0035011]; mesoderm development [GO:0007498]; negative regulation of synaptic assembly at neuromuscular junction [GO:0045886]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; substrate adhesion-dependent cell spreading [GO:0034446]; tissue development [GO:0009888]	extracellular matrix structural constituent [GO:0005201]; signaling receptor binding [GO:0005102]	axon [GO:0030424]; basement membrane [GO:0005604]; extracellular matrix [GO:0031012]; presynaptic periactive zone [GO:0036062]; synaptic vesicle [GO:0008021]	GO:0005102; GO:0005201; GO:0005604; GO:0007411; GO:0007498; GO:0007507; GO:0008021; GO:0009887; GO:0009888; GO:0030155; GO:0030334; GO:0030424; GO:0031012; GO:0033627; GO:0034446; GO:0035001; GO:0035011; GO:0036062; GO:0045886; GO:0045995; GO:0071711
GN010995	GN010995.1	Q9I9B9	36.5	627	664	646	2.78e-113	357	CTL1_TORMA	Choline transporter-like protein 1 (Solute carrier family 44 member 1)	Torpedo marmorata (Marbled electric ray)	choline transport [GO:0015871]; ethanolamine transport [GO:0034229]	choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]	mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]	GO:0005741; GO:0005886; GO:0015220; GO:0015871; GO:0034228; GO:0034229
GN010996	GN010996.1	Q9ESN3	28.9	723	770	769	1.21e-78	271	PGAP6_MOUSE	Post-GPI attachment to proteins factor 6 (EC 3.1.1.4) (GPI processing phospholipase A2) (GPI-PLA2) (M83 protein) (Transmembrane protein 8) (Transmembrane protein 8A)	Mus musculus (Mouse)		A2-type glycerophospholipase activity [GO:0004623]	lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0004623; GO:0005654; GO:0005765; GO:0005886
GN010999	GN010999.1	Q0GGW5	65.8	325	417	440	1.34e-152	442	STK11_CHICK	Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1 homolog) (LKB1)	Gallus gallus (Chicken)	activation of protein kinase activity [GO:0032147]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; establishment of cell polarity [GO:0030010]; glucose homeostasis [GO:0042593]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; positive regulation of vesicle transport along microtubule [GO:1901610]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of Wnt signaling pathway [GO:0030111]; response to ionizing radiation [GO:0010212]; response to xenobiotic stimulus [GO:0009410]; vasculature development [GO:0001944]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; p53 binding [GO:0002039]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; late endosome [GO:0005770]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0000287; GO:0001558; GO:0001944; GO:0002039; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005770; GO:0005829; GO:0006468; GO:0006470; GO:0006974; GO:0009267; GO:0009410; GO:0010212; GO:0016020; GO:0019901; GO:0030010; GO:0030111; GO:0030295; GO:0030308; GO:0032147; GO:0042593; GO:0046777; GO:0072332; GO:0090090; GO:0106310; GO:1901610
GN011000	GN011000.1	Q8JFW1	42.1	665	633	612	1.37e-148	446	ASND1_DANRE	Asparagine synthetase domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)				
GN011004	GN011004.1	Q9ESM0	44.0	407	391	433	2.06e-109	330	IP6K1_RAT	Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1)	Rattus norvegicus (Rat)	inositol phosphate biosynthetic process [GO:0032958]; negative regulation of cold-induced thermogenesis [GO:0120163]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]	inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000828; GO:0000832; GO:0001650; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0032958; GO:0046854; GO:0120163
GN011006	GN011006.1	Q9R244	25.4	472	1563	1172	6.08e-22	107	TRPC2_MOUSE	Short transient receptor potential channel 2 (TrpC2) (Transient receptor protein 2) (TRP-2) (mTrp2)	Mus musculus (Mouse)	acrosome reaction [GO:0007340]; aggressive behavior [GO:0002118]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; female courtship behavior [GO:0008050]; inter-male aggressive behavior [GO:0002121]; mating behavior, sex discrimination [GO:0048047]; negative regulation of male mating behavior [GO:1902436]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of gene expression [GO:0010468]; response to decreased oxygen levels [GO:0036293]; response to pheromone [GO:0019236]; single fertilization [GO:0007338]; single strand break repair [GO:0000012]; territorial aggressive behavior [GO:0002124]	calmodulin binding [GO:0005516]; damaged DNA binding [GO:0003684]; diacylglycerol binding [GO:0019992]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]	cation channel complex [GO:0034703]; dendrite membrane [GO:0032590]; dendritic knob [GO:0098788]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000012; GO:0000139; GO:0002118; GO:0002121; GO:0002124; GO:0003684; GO:0005516; GO:0005634; GO:0005635; GO:0005789; GO:0005886; GO:0006816; GO:0007204; GO:0007338; GO:0007340; GO:0008050; GO:0010468; GO:0012505; GO:0015279; GO:0019236; GO:0019992; GO:0032590; GO:0034703; GO:0036293; GO:0048047; GO:0051480; GO:0070588; GO:0070679; GO:0098788; GO:1902436
GN011010	GN011010.1	Q6PD10	53.8	52	80	433	3.08e-14	68.9	IP6K1_MOUSE	Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1)	Mus musculus (Mouse)	inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; negative regulation of cold-induced thermogenesis [GO:0120163]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]	inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000828; GO:0000832; GO:0001650; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006020; GO:0032958; GO:0046854; GO:0120163
GN011012	GN011012.1	Q9R244	25.4	472	1459	1172	5.50e-22	107	TRPC2_MOUSE	Short transient receptor potential channel 2 (TrpC2) (Transient receptor protein 2) (TRP-2) (mTrp2)	Mus musculus (Mouse)	acrosome reaction [GO:0007340]; aggressive behavior [GO:0002118]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; female courtship behavior [GO:0008050]; inter-male aggressive behavior [GO:0002121]; mating behavior, sex discrimination [GO:0048047]; negative regulation of male mating behavior [GO:1902436]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of gene expression [GO:0010468]; response to decreased oxygen levels [GO:0036293]; response to pheromone [GO:0019236]; single fertilization [GO:0007338]; single strand break repair [GO:0000012]; territorial aggressive behavior [GO:0002124]	calmodulin binding [GO:0005516]; damaged DNA binding [GO:0003684]; diacylglycerol binding [GO:0019992]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]	cation channel complex [GO:0034703]; dendrite membrane [GO:0032590]; dendritic knob [GO:0098788]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000012; GO:0000139; GO:0002118; GO:0002121; GO:0002124; GO:0003684; GO:0005516; GO:0005634; GO:0005635; GO:0005789; GO:0005886; GO:0006816; GO:0007204; GO:0007338; GO:0007340; GO:0008050; GO:0010468; GO:0012505; GO:0015279; GO:0019236; GO:0019992; GO:0032590; GO:0034703; GO:0036293; GO:0048047; GO:0051480; GO:0070588; GO:0070679; GO:0098788; GO:1902436
GN011014	GN011014.1	P68102	71.5	302	327	315	1.01e-149	426	IF2A_BOVIN	Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha)	Bos taurus (Bovine)	cellular response to amino acid starvation [GO:0034198]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; HRI-mediated signaling [GO:0140468]; mitophagy [GO:0000423]; negative regulation of translational initiation in response to stress [GO:0032057]; PERK-mediated unfolded protein response [GO:0036499]; regulation of translation in response to endoplasmic reticulum stress [GO:0036490]; regulation of translational initiation in response to stress [GO:0043558]; response to endoplasmic reticulum stress [GO:0034976]; stress granule assembly [GO:0034063]; translation [GO:0006412]; translational initiation [GO:0006413]	cap-dependent translation initiation factor activity [GO:0160296]; IRES-mediated translation initiation factor activity [GO:0160297]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 2 complex [GO:0005850]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; synapse [GO:0045202]	GO:0000423; GO:0003723; GO:0003743; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005850; GO:0006412; GO:0006413; GO:0010494; GO:0032057; GO:0033290; GO:0034063; GO:0034198; GO:0034599; GO:0034644; GO:0034976; GO:0036490; GO:0036499; GO:0043022; GO:0043558; GO:0045202; GO:0140468; GO:0160296; GO:0160297
GN011015	GN011015.1	Q1T7C1	30.5	246	247	260	3.12e-24	100	CENPK_CHICK	Centromere protein K (CENP-K)	Gallus gallus (Chicken)	kinetochore assembly [GO:0051382]; mitotic sister chromatid segregation [GO:0000070]		inner kinetochore [GO:0000939]; nucleus [GO:0005634]	GO:0000070; GO:0000939; GO:0005634; GO:0051382
GN011016	GN011016.1	Q6UXP7	40.3	238	540	276	6.11e-47	168	F151B_HUMAN	Protein FAM151B	Homo sapiens (Human)	photoreceptor cell development [GO:0042461]			GO:0042461
GN011018	GN011018.1	Q9JMA7	40.4	188	186	504	4.30e-38	139	CP341_MOUSE	Cytochrome P450 3A41 (EC 1.14.14.1)	Mus musculus (Mouse)	alkaloid catabolic process [GO:0009822]; estrogen metabolic process [GO:0008210]; lipid hydroxylation [GO:0002933]; oxidative demethylation [GO:0070989]; regulation of gene expression [GO:0010468]; response to bacterium [GO:0009617]; retinoic acid metabolic process [GO:0042573]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]	demethylase activity [GO:0032451]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]; testosterone 6-beta-hydroxylase activity [GO:0050649]	endoplasmic reticulum membrane [GO:0005789]	GO:0002933; GO:0004497; GO:0005506; GO:0005789; GO:0008202; GO:0008210; GO:0008401; GO:0009617; GO:0009822; GO:0010468; GO:0016491; GO:0016712; GO:0020037; GO:0032451; GO:0042178; GO:0042573; GO:0050649; GO:0070989; GO:0101020; GO:0101021
GN011021	GN011021.1	Q9NA75	60.7	229	254	295	6.54e-98	291	T38B1_CAEEL	Trimeric intracellular cation channel type 1B.1 (TRIC-1B.1) (TRIC-B1)	Caenorhabditis elegans	potassium ion transmembrane transport [GO:0071805]	identical protein binding [GO:0042802]; potassium channel activity [GO:0005267]	endoplasmic reticulum membrane [GO:0005789]; sarcoplasmic reticulum membrane [GO:0033017]	GO:0005267; GO:0005789; GO:0033017; GO:0042802; GO:0071805
GN011022	GN011022.1	Q6PID6	46.5	217	300	262	1.93e-53	178	TTC33_HUMAN	Tetratricopeptide repeat protein 33 (TPR repeat protein 33) (Osmosis-responsive factor)	Homo sapiens (Human)				
GN011023	GN011023.1	Q7ZV90	54.8	624	623	639	4.71e-231	657	PIF1_DANRE	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0000723; GO:0005524; GO:0005634; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0043139
GN011024	GN011024.1	Q8C206	25.1	287	353	330	1.16e-16	83.2	GP157_MOUSE	G protein-coupled receptor 157	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; radial glial cell differentiation [GO:0060019]	G protein-coupled receptor activity [GO:0004930]	ciliary membrane [GO:0060170]	GO:0004930; GO:0007166; GO:0007189; GO:0007200; GO:0048512; GO:0060019; GO:0060170
GN011025	GN011025.1	Q27218	28.7	310	392	507	1.23e-30	125	ACH7_CAEEL	Acetylcholine receptor subunit beta-type lev-1 (Levamisole-resistant protein 1)	Caenorhabditis elegans	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of egg-laying behavior [GO:0046662]; regulation of locomotion [GO:0040012]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]; transmembrane transport [GO:0055085]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0040012; GO:0042391; GO:0043005; GO:0043025; GO:0045202; GO:0045211; GO:0046662; GO:0055085
GN011026	GN011026.1	P18754	46.9	403	439	421	3.30e-118	354	RCC1_HUMAN	Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)	Homo sapiens (Human)	chromosome segregation [GO:0007059]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic nuclear membrane reassembly [GO:0007084]; mitotic spindle organization [GO:0007052]; positive regulation of cell cycle process [GO:0090068]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic nuclear division [GO:0007088]; regulation of mitotic spindle assembly [GO:1901673]; spindle assembly [GO:0051225]; viral process [GO:0016032]	chromatin binding [GO:0003682]; guanyl-nucleotide exchange factor activity [GO:0005085]; histone binding [GO:0042393]; nucleosomal DNA binding [GO:0031492]; nucleosome binding [GO:0031491]; protein heterodimerization activity [GO:0046982]; small GTPase binding [GO:0031267]; sulfate binding [GO:0043199]	chromatin [GO:0000785]; chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000082; GO:0000785; GO:0000794; GO:0003682; GO:0005085; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0007052; GO:0007059; GO:0007084; GO:0007088; GO:0007346; GO:0016032; GO:0031267; GO:0031491; GO:0031492; GO:0032991; GO:0042393; GO:0043199; GO:0046982; GO:0051225; GO:0090068; GO:1901673
GN011027	GN011027.1	Q9VHI4	85.9	85	85	85	1.68e-52	161	SF3B5_DROME	Splicing factor 3B subunit 5 (Pre-mRNA-splicing factor SF3b 10 kDa subunit)	Drosophila melanogaster (Fruit fly)	mRNA splicing, via spliceosome [GO:0000398]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of gene expression [GO:0010468]		nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; SAGA complex [GO:0000124]; U2 snRNP [GO:0005686]	GO:0000124; GO:0000398; GO:0005634; GO:0005686; GO:0010468; GO:0045893; GO:0071011
GN011029	GN011029.1	Q9UBC2	47.6	420	802	864	1.96e-106	349	EP15R_HUMAN	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)	Homo sapiens (Human)	synaptic vesicle endocytosis [GO:0048488]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; protein-macromolecule adaptor activity [GO:0030674]	clathrin coat of coated pit [GO:0030132]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0005509; GO:0005634; GO:0005829; GO:0005886; GO:0016020; GO:0030132; GO:0030674; GO:0045296; GO:0048488; GO:0098793
GN011030	GN011030.1	Q5TB30	30.3	627	635	811	2.84e-59	216	DEP1A_HUMAN	DEP domain-containing protein 1A	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]; negative regulation of DNA-templated transcription [GO:0045892]		fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	GO:0001650; GO:0005634; GO:0005654; GO:0017053; GO:0035556; GO:0045892
GN011031	GN011031.1	A2A8Z1	51.9	680	662	736	1.41e-231	664	OSBL9_MOUSE	Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9)	Mus musculus (Mouse)	lysosomal membrane organization [GO:0097212]; phospholipid homeostasis [GO:0055091]; phospholipid transfer to membrane [GO:0006649]	lipid binding [GO:0008289]; phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity [GO:0160270]	cytosol [GO:0005829]; endoplasmic reticulum-endosome membrane contact site [GO:0140284]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endoplasmic reticulum-trans-Golgi network membrane contact site [GO:0160258]; Golgi apparatus [GO:0005794]; intermembrane lipid transporter complex [GO:7770015]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; trans-Golgi network [GO:0005802]; transporter complex [GO:1990351]	GO:0005765; GO:0005794; GO:0005802; GO:0005829; GO:0006649; GO:0008289; GO:0016020; GO:0031902; GO:0032991; GO:0033116; GO:0055091; GO:0097212; GO:0140284; GO:0160258; GO:0160270; GO:1990351; GO:7770015
GN011032	GN011032.1	Q15262	42.5	603	1052	1439	9.33e-155	499	PTPRK_HUMAN	Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)	Homo sapiens (Human)	cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]	beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; organelle [GO:0043226]; plasma membrane [GO:0005886]	GO:0004725; GO:0005001; GO:0005886; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016020; GO:0016477; GO:0019901; GO:0030054; GO:0030336; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043226; GO:0045295; GO:0045786; GO:0045892; GO:0048041
GN011033	GN011033.1	Q99489	42.7	335	346	341	3.76e-83	258	OXDD_HUMAN	D-aspartate oxidase (DASOX) (DASPO) (DDO) (EC 1.4.3.1)	Homo sapiens (Human)	aspartate metabolic process [GO:0006531]; D-amino acid catabolic process [GO:0019478]; L-amino acid catabolic process [GO:0170035]; L-aspartate catabolic process [GO:0006533]; nervous system process [GO:0050877]; proteinogenic amino acid catabolic process [GO:0170040]; regulation of cell communication [GO:0010646]	D-aspartate oxidase activity [GO:0008445]; D-glutamate oxidase activity [GO:0047821]; FAD binding [GO:0071949]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0005777; GO:0005782; GO:0005829; GO:0006531; GO:0006533; GO:0008445; GO:0010646; GO:0019478; GO:0047821; GO:0050877; GO:0071949; GO:0170035; GO:0170040
GN011037	GN011037.1	P0C7N0	37.2	215	225	267	1.75e-27	108	RWDD3_RAT	RWD domain-containing protein 3 (RWD domain-containing sumoylation enhancer) (RSUME)	Rattus norvegicus (Rat)	positive regulation of hypoxia-inducible factor-1alpha signaling pathway [GO:1902073]; positive regulation of protein sumoylation [GO:0033235]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0033235; GO:1902073
GN011039	GN011039.1	Q92624	24.6	394	797	585	3.56e-20	99.0	APBP2_HUMAN	Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1)	Homo sapiens (Human)	intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; negative regulation of beige fat cell differentiation [GO:0160276]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	microtubule motor activity [GO:0003777]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003777; GO:0005634; GO:0005654; GO:0005737; GO:0005875; GO:0006886; GO:0016020; GO:0016567; GO:0030659; GO:0031462; GO:0043161; GO:0046907; GO:0140627; GO:0160276; GO:1990756
GN011040	GN011040.1	O88696	63.5	189	225	272	4.32e-83	251	CLPP_MOUSE	ATP-dependent Clp protease proteolytic subunit, mitochondrial (EC 3.4.21.92) (Caseinolytic mitochondrial matrix peptidase proteolytic subunit) (Endopeptidase Clp)	Mus musculus (Mouse)	membrane protein proteolysis [GO:0033619]; protein catabolic process [GO:0030163]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis [GO:0006508]	ATP-dependent peptidase activity [GO:0004176]; ATPase binding [GO:0051117]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]	endopeptidase Clp complex [GO:0009368]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004175; GO:0004176; GO:0004252; GO:0005739; GO:0005759; GO:0006508; GO:0006515; GO:0009368; GO:0030163; GO:0033619; GO:0042802; GO:0051117
GN011043	GN011043.1	Q95KD9	79.9	199	233	199	4.22e-109	315	DIRA2_MACFA	GTP-binding protein Di-Ras2 (EC 3.6.5.-) (Distinct subgroup of the Ras family member 2)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	signal transduction [GO:0007165]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]	GO:0003924; GO:0005525; GO:0005886; GO:0007165
GN011045	GN011045.1	P97864	49.8	247	306	303	6.12e-81	250	CASP7_MOUSE	Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]	Mus musculus (Mouse)	apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to staurosporine [GO:0072734]; ceramide biosynthetic process [GO:0046513]; defense response to bacterium [GO:0042742]; execution phase of apoptosis [GO:0097194]; heart development [GO:0007507]; lymphocyte apoptotic process [GO:0070227]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron apoptotic process [GO:0051402]; plasma membrane repair [GO:0001778]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of plasma membrane repair [GO:1905686]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein poly-ADP-ribosylation [GO:0070212]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of transcription by RNA polymerase II [GO:0006357]; response to UV [GO:0009411]; striated muscle cell differentiation [GO:0051146]	aspartic-type endopeptidase activity [GO:0004190]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]	caspase complex [GO:0008303]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000122; GO:0001650; GO:0001778; GO:0003723; GO:0004190; GO:0004197; GO:0005576; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006357; GO:0006508; GO:0006915; GO:0007507; GO:0008233; GO:0008234; GO:0008303; GO:0009411; GO:0016485; GO:0030163; GO:0042742; GO:0043065; GO:0043123; GO:0043525; GO:0046513; GO:0051146; GO:0051402; GO:0051604; GO:0070212; GO:0070227; GO:0070269; GO:0071222; GO:0072734; GO:0097194; GO:1905686
GN011046	GN011046.1	B2RS91	41.6	592	588	656	9.13e-133	405	RRN3_MOUSE	RNA polymerase I-specific transcription initiation factor RRN3	Mus musculus (Mouse)	cell population proliferation [GO:0008283]; cytoplasm organization [GO:0007028]; DNA-templated transcription initiation [GO:0006352]; homeostasis of number of cells [GO:0048872]; in utero embryonic development [GO:0001701]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; nucleolus organization [GO:0007000]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection development [GO:0010976]; regulation of DNA-templated transcription initiation [GO:2000142]; ribosome biogenesis [GO:0042254]; transcription initiation at RNA polymerase I promoter [GO:0006361]	RNA polymerase binding [GO:0070063]; RNA polymerase I core binding [GO:0001042]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase I general transcription initiation factor activity [GO:0001181]	nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0001042; GO:0001164; GO:0001181; GO:0001701; GO:0005634; GO:0005730; GO:0006352; GO:0006361; GO:0007000; GO:0007028; GO:0008283; GO:0010976; GO:0042254; GO:0045893; GO:0048872; GO:0070063; GO:1902254; GO:2000142
GN011047	GN011047.1	Q09003	45.7	81	471	536	4.84e-12	71.6	COIL_XENLA	Coilin (Sphere organelles protein SPH-1) (Sphere protein 1)	Xenopus laevis (African clawed frog)	spliceosomal snRNP assembly [GO:0000387]	U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]	Cajal body [GO:0015030]; sphere organelle [GO:0071601]	GO:0000387; GO:0015030; GO:0030619; GO:0030620; GO:0071601
GN011049	GN011049.1	Q6DDU8	47.1	703	714	655	2.38e-177	524	FIGL1_XENLA	Fidgetin-like protein 1 (EC 3.6.4.-)	Xenopus laevis (African clawed frog)	ATP metabolic process [GO:0046034]; DNA recombinase disassembly [GO:1990986]; double-strand break repair involved in meiotic recombination [GO:1990918]; microtubule severing [GO:0051013]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein hexamerization [GO:0034214]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; microtubule severing ATPase activity [GO:0008568]; protein-containing complex destabilizing activity [GO:0140776]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear chromosome [GO:0000228]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0000228; GO:0000287; GO:0000785; GO:0005524; GO:0005634; GO:0005737; GO:0008568; GO:0016787; GO:0016887; GO:0034214; GO:0046034; GO:0048471; GO:0051013; GO:0140776; GO:1990918; GO:1990986; GO:2000042
GN011050	GN011050.1	Q5QJE6	61.8	123	127	756	2.47e-45	159	TDIF2_HUMAN	Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)	Homo sapiens (Human)	maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; RNA processing [GO:0006396]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]	GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0006396; GO:0030490; GO:0032040; GO:0042274
GN011051	GN011051.1	Q96SJ8	29.2	257	450	248	6.47e-27	111	TSN18_HUMAN	Tetraspanin-18 (Tspan-18)	Homo sapiens (Human)	calcium-ion regulated exocytosis [GO:0017156]; calcium-mediated signaling [GO:0019722]; inflammatory response [GO:0006954]; protein localization to cell periphery [GO:1990778]; regulation of sprouting angiogenesis [GO:1903670]; regulation of store-operated calcium entry [GO:2001256]	transmembrane transporter binding [GO:0044325]	cell periphery [GO:0071944]; plasma membrane [GO:0005886]	GO:0005886; GO:0006954; GO:0017156; GO:0019722; GO:0044325; GO:0071944; GO:1903670; GO:1990778; GO:2001256
GN011054	GN011054.1	Q09506	46.8	126	155	124	4.19e-37	126	TX1B3_CAEEL	Tax1-binding protein 3 homolog	Caenorhabditis elegans				
GN011055	GN011055.1	Q5H8A4	36.4	927	922	983	1.80e-147	464	PIGG_HUMAN	GPI ethanolamine phosphate transferase 2, catalytic subunit (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G)	Homo sapiens (Human)	GPI anchor biosynthetic process [GO:0006506]	mannose-ethanolamine phosphotransferase activity [GO:0051377]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; transferase activity [GO:0016740]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0005783; GO:0005789; GO:0006506; GO:0016020; GO:0016740; GO:0016780; GO:0051377
GN011056	GN011056.1	Q9GZN2	69.9	83	228	237	2.27e-37	133	TGIF2_HUMAN	Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000978; GO:0000981; GO:0001227; GO:0003700; GO:0005634; GO:0005654; GO:0006355; GO:1990837
GN011057	GN011057.1	B0WEV5	72.0	329	329	348	6.57e-173	486	ASNA_CULQU	ATPase ASNA1 homolog (EC 3.6.-.-) (Arsenical pump-driving ATPase homolog) (Arsenite-stimulated ATPase)	Culex quinquefasciatus (Southern house mosquito) (Culex pungens)	tail-anchored membrane protein insertion into ER membrane [GO:0071816]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	GET complex [GO:0043529]	GO:0005524; GO:0016887; GO:0043529; GO:0071816
GN011058	GN011058.1	Q9FE17	33.0	233	377	473	2.17e-24	107	SIR1_ARATH	NAD-dependent protein deacetylase SRT1 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1)	Arabidopsis thaliana (Mouse-ear cress)	ethylene-activated signaling pathway [GO:0009873]; negative regulation of transcription by RNA polymerase II [GO:0000122]	chromatin DNA binding [GO:0031490]; histone deacetylase activity, NAD-dependent [GO:0017136]; histone H3K9 acetyltransferase activity [GO:0043992]; NAD+ binding [GO:0070403]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000122; GO:0003714; GO:0005634; GO:0005737; GO:0009873; GO:0017136; GO:0031490; GO:0043992; GO:0070403
GN011063	GN011063.1	Q3U487	41.6	855	833	861	6.74e-224	655	HECD3_MOUSE	E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)	Mus musculus (Mouse)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	syntaxin binding [GO:0019905]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	perinuclear region of cytoplasm [GO:0048471]	GO:0004842; GO:0016567; GO:0019905; GO:0043161; GO:0048471; GO:0061630
GN011066	GN011066.1	P09324	54.1	464	505	541	1.89e-167	487	YES_CHICK	Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)	Gallus gallus (Chicken)	cell differentiation [GO:0030154]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]	anchoring junction [GO:0070161]; centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	GO:0001784; GO:0004715; GO:0005102; GO:0005524; GO:0005794; GO:0005813; GO:0005829; GO:0005886; GO:0007169; GO:0019899; GO:0030154; GO:0044325; GO:0070161
GN011071	GN011071.1	Q8TDD5	40.7	548	627	553	2.17e-126	387	MCLN3_HUMAN	Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3)	Homo sapiens (Human)	calcium ion transmembrane transport [GO:0070588]	calcium channel activity [GO:0005262]; monoatomic anion channel activity [GO:0005253]; NAADP-sensitive calcium-release channel activity [GO:0072345]; potassium channel activity [GO:0005267]; sodium channel activity [GO:0005272]	autophagosome membrane [GO:0000421]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	GO:0000421; GO:0005253; GO:0005262; GO:0005267; GO:0005272; GO:0005765; GO:0005886; GO:0031901; GO:0031902; GO:0070588; GO:0072345
GN011073	GN011073.1	P50533	82.2	90	124	1203	3.95e-41	147	SMC2_XENLA	Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome assembly protein XCAP-E) (Chromosome-associated protein E)	Xenopus laevis (African clawed frog)	chromosome organization [GO:0051276]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	chromosome [GO:0005694]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005524; GO:0005634; GO:0005694; GO:0005829; GO:0016887; GO:0051276
GN011074	GN011074.1	O95347	57.7	1084	1227	1197	1.83e-282	832	SMC2_HUMAN	Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog)	Homo sapiens (Human)	B cell differentiation [GO:0030183]; cerebral cortex development [GO:0021987]; immunoglobulin heavy chain V-D-J recombination [GO:0071707]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; condensed chromosome [GO:0000793]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000228; GO:0000785; GO:0000793; GO:0000794; GO:0000796; GO:0003682; GO:0003697; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0007076; GO:0016887; GO:0021987; GO:0030183; GO:0051984; GO:0070062; GO:0071707; GO:1905820; GO:1905821
GN011076	GN011076.1	O97860	48.2	307	329	325	9.45e-97	292	PPA5_RABIT	Tartrate-resistant acid phosphatase type 5 (TR-AP) (EC 3.1.3.2) (Purple acid phosphatase) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase)	Oryctolagus cuniculus (Rabbit)	bone resorption [GO:0045453]	acid phosphatase activity [GO:0003993]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]	lysosome [GO:0005764]	GO:0003993; GO:0005764; GO:0008198; GO:0008199; GO:0045453
GN011077	GN011077.1	Q8BMS1	61.2	763	759	763	0.0	896	ECHA_MOUSE	Trifunctional enzyme subunit alpha, mitochondrial (Monolysocardiolipin acyltransferase) (MLCL AT) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (LCEH) (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) (EC 1.1.1.211)]	Mus musculus (Mouse)	cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid beta-oxidation [GO:0006635]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0003857]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; acetyl-CoA C-acyltransferase activity [GO:0003988]; enoyl-CoA hydratase activity [GO:0004300]; fatty-acyl-CoA binding [GO:0000062]; long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0016509]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; NAD binding [GO:0051287]; NAD+ binding [GO:0070403]; protein-containing complex binding [GO:0044877]	mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	GO:0000062; GO:0003857; GO:0003988; GO:0004300; GO:0005739; GO:0005743; GO:0006635; GO:0009410; GO:0016507; GO:0016509; GO:0018812; GO:0032868; GO:0035965; GO:0042645; GO:0044877; GO:0051287; GO:0052816; GO:0070403
GN011078	GN011078.1	O46629	65.9	466	468	475	2.33e-209	589	ECHB_BOVIN	Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (3-oxoacyl-CoA thiolase) (Acetyl-CoA acyltransferase) (Beta-ketothiolase) (Long chain 3-ketoacyl-CoA thiolase) (LCKAT)]	Bos taurus (Bovine)	fatty acid beta-oxidation [GO:0006635]	acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]	endoplasmic reticulum [GO:0005783]; mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0003988; GO:0005739; GO:0005741; GO:0005743; GO:0005783; GO:0006635; GO:0016507; GO:0050633
GN011079	GN011079.1	Q07598	66.2	526	538	547	2.47e-254	709	SCP2_CHICK	Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (SCPX) (Sterol carrier protein X) (SCP-X)	Gallus gallus (Chicken)	bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation [GO:0006635]; lipid transport [GO:0006869]	acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; cholesterol transfer activity [GO:0120020]; phosphatidylcholine transfer activity [GO:0120019]; propanoyl-CoA C-acyltransferase activity [GO:0033814]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0003988; GO:0005737; GO:0005739; GO:0005777; GO:0005782; GO:0005783; GO:0006635; GO:0006869; GO:0008206; GO:0033814; GO:0050633; GO:0120019; GO:0120020
GN011081	GN011081.1	B1H283	38.1	383	424	402	7.70e-78	249	CMAP2_RAT	Ciliary microtubule-associated protein 2 (Lymphocyte expansion molecule)	Rattus norvegicus (Rat)				
GN011082	GN011082.1	Q8TB45	34.3	303	293	409	3.90e-38	142	DPTOR_HUMAN	DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6)	Homo sapiens (Human)	G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of cell size [GO:0045792]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of TORC2 signaling [GO:1903940]; positive regulation of autophagy [GO:0010508]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidic acid binding [GO:0070300]; protein kinase inhibitor activity [GO:0004860]; protein serine/threonine kinase inhibitor activity [GO:0030291]	lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	GO:0004860; GO:0005085; GO:0005096; GO:0005765; GO:0005886; GO:0006469; GO:0007186; GO:0010508; GO:0030291; GO:0032007; GO:0035556; GO:0045792; GO:0070300; GO:1903940; GO:1904262; GO:2001236
GN011083	GN011083.1	Q7SY48	34.6	2195	2065	2159	0.0	1093	HEAT1_DANRE	HEAT repeat-containing protein 1 (Protein BAP28)	Danio rerio (Zebrafish) (Brachydanio rerio)	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; positive regulation of transcription by RNA polymerase I [GO:0045943]; protein localization to nucleolus [GO:1902570]; regulation of RNA stability [GO:0043487]; ribosomal small subunit biogenesis [GO:0042274]; rRNA metabolic process [GO:0016072]	snoRNA binding [GO:0030515]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455]	GO:0000462; GO:0005730; GO:0016072; GO:0030515; GO:0030686; GO:0032040; GO:0034455; GO:0042274; GO:0043066; GO:0043487; GO:0045943; GO:0061351; GO:1902570
GN011084	GN011084.1	Q69Z66	33.5	935	901	819	2.76e-129	411	MYSM1_MOUSE	Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1)	Mus musculus (Mouse)	chromatin remodeling [GO:0006338]; pigmentation [GO:0043473]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell migration [GO:0030334]; regulation of hair follicle development [GO:0051797]; regulation of hemopoiesis [GO:1903706]	histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; metal-dependent deubiquitinase activity [GO:0140492]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006338; GO:0030334; GO:0032991; GO:0042393; GO:0043473; GO:0045944; GO:0051797; GO:0140492; GO:0140950; GO:1903706
GN011085	GN011085.1	O97827	34.6	720	1157	1580	9.50e-116	397	AGRL3_BOVIN	Adhesion G protein-coupled receptor L3 (Latrophilin-3)	Bos taurus (Bovine)	cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; excitatory synapse assembly [GO:1904861]; neuron migration [GO:0001764]; Rho-activating G protein-coupled receptor signaling pathway [GO:0160221]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; cell adhesion mediator activity [GO:0098631]; G protein-coupled receptor activity [GO:0004930]	anchoring junction [GO:0070161]; axon [GO:0030424]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0001764; GO:0004930; GO:0005509; GO:0005886; GO:0005911; GO:0007165; GO:0007166; GO:0007416; GO:0030246; GO:0030424; GO:0045211; GO:0070161; GO:0098609; GO:0098631; GO:0160221; GO:1904861
GN011086	GN011086.1	Q9FT72	25.7	491	513	713	5.94e-33	136	RQL3_ARATH	ATP-dependent DNA helicase Q-like 3 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ3) (RecQ-like protein 3) (AtRecQ3) (AtRecQl3)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004386; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006310; GO:0009378; GO:0016887; GO:0043138; GO:1990814
GN011088	GN011088.1	P05183	37.4	211	217	504	1.15e-33	129	CP3A2_RAT	Cytochrome P450 3A2 (EC 1.14.14.1) (CYPIIIA2) (Cytochrome P450-PCN2) (Cytochrome P450/6-beta-A) (Testosterone 6-beta-hydroxylase)	Rattus norvegicus (Rat)	alkaloid catabolic process [GO:0009822]; estrogen metabolic process [GO:0008210]; glutathione catabolic process [GO:0006751]; lipid hydroxylation [GO:0002933]; monoterpenoid metabolic process [GO:0016098]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; steroid metabolic process [GO:0008202]; sulfur oxidation [GO:0019417]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	1,8-cineole 2-exo-monooxygenase activity [GO:0102320]; 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity [GO:0062181]; anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; caffeine oxidase activity [GO:0034875]; demethylase activity [GO:0032451]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; quinine 3-monooxygenase activity [GO:0050591]; retinoic acid 4-hydroxylase activity [GO:0008401]; steroid binding [GO:0005496]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]; vitamin D 24-hydroxylase activity [GO:0070576]; vitamin D 25-hydroxylase activity [GO:0030343]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	GO:0002933; GO:0004497; GO:0005496; GO:0005506; GO:0005737; GO:0005789; GO:0006706; GO:0006751; GO:0006805; GO:0008202; GO:0008210; GO:0008395; GO:0008401; GO:0009822; GO:0016098; GO:0016491; GO:0016712; GO:0019417; GO:0019899; GO:0020037; GO:0030343; GO:0032451; GO:0034875; GO:0042178; GO:0042359; GO:0042369; GO:0042572; GO:0042573; GO:0050591; GO:0050649; GO:0062181; GO:0062187; GO:0062188; GO:0062189; GO:0070576; GO:0070989; GO:0101020; GO:0101021; GO:0102320
GN011093	GN011093.1	V5NAL9	36.2	735	773	899	9.60e-148	458	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN011096	GN011096.1	Q95J53	30.0	646	711	504	3.98e-84	278	BTBDG_MACFA	BTB/POZ domain-containing protein 16	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)				
GN011097	GN011097.1	O95395	40.9	374	451	438	1.88e-83	266	GCNT3_HUMAN	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (hC2GnT-M) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase) (C2/4GnT)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via N-acetyl-galactosamine [GO:0016266]	acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0047225]; acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0003829; GO:0005975; GO:0006493; GO:0008109; GO:0008375; GO:0016020; GO:0016266; GO:0047225; GO:0070062
GN011098	GN011098.1	O95395	39.8	379	390	438	1.74e-82	261	GCNT3_HUMAN	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (hC2GnT-M) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase) (C2/4GnT)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via N-acetyl-galactosamine [GO:0016266]	acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0047225]; acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0003829; GO:0005975; GO:0006493; GO:0008109; GO:0008375; GO:0016020; GO:0016266; GO:0047225; GO:0070062
GN011099	GN011099.1	O95395	42.4	342	353	438	2.06e-82	260	GCNT3_HUMAN	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (hC2GnT-M) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase) (C2/4GnT)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via N-acetyl-galactosamine [GO:0016266]	acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0047225]; acetylglucosaminyltransferase activity [GO:0008375]; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity [GO:0003829]; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity [GO:0008109]	extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0003829; GO:0005975; GO:0006493; GO:0008109; GO:0008375; GO:0016020; GO:0016266; GO:0047225; GO:0070062
GN011100	GN011100.1	Q8C1A5	64.5	656	663	687	3.02e-303	844	THOP1_MOUSE	Thimet oligopeptidase (EC 3.4.24.15)	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; peptide catabolic process [GO:0043171]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]	GO:0004222; GO:0005737; GO:0005758; GO:0005829; GO:0006508; GO:0006518; GO:0008233; GO:0035556; GO:0042277; GO:0043171
GN011101	GN011101.1	P24155	54.6	657	603	687	5.90e-236	671	THOP1_RAT	Thimet oligopeptidase (EC 3.4.24.15) (Endo-oligopeptidase A) (Endopeptidase 24.15) (PZ-peptidase) (Soluble metallo-endopeptidase)	Rattus norvegicus (Rat)	intracellular signal transduction [GO:0035556]; peptide catabolic process [GO:0043171]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]	GO:0004222; GO:0005737; GO:0005758; GO:0005829; GO:0006508; GO:0006518; GO:0008233; GO:0035556; GO:0042277; GO:0043171
GN011102	GN011102.1	Q13635	48.3	1175	1318	1447	0.0	1041	PTC1_HUMAN	Protein patched homolog 1 (PTC) (PTC1)	Homo sapiens (Human)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; cellular response to cholesterol [GO:0071397]; commissural neuron axon guidance [GO:0071679]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; liver regeneration [GO:0097421]; metanephric collecting duct development [GO:0072205]; negative regulation of cell division [GO:0051782]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural plate axis specification [GO:0021997]; neural tube formation [GO:0001841]; neural tube patterning [GO:0021532]; pharyngeal system development [GO:0060037]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of DNA-templated transcription [GO:0045893]; prostate gland development [GO:0030850]; protein localization to plasma membrane [GO:0072659]; protein processing [GO:0016485]; regulation of protein localization [GO:0032880]; regulation of smoothened signaling pathway [GO:0008589]; response to alkaloid [GO:0043279]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to retinoic acid [GO:0032526]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; smooth muscle tissue development [GO:0048745]; somite development [GO:0061053]; spermatid development [GO:0007286]	cholesterol binding [GO:0015485]; cyclin binding [GO:0030332]; hedgehog family protein binding [GO:0097108]; hedgehog receptor activity [GO:0008158]; heparin binding [GO:0008201]; intramembrane lipid carrier activity [GO:0140303]; patched binding [GO:0005113]; protein-containing complex binding [GO:0044877]; smoothened binding [GO:0005119]	apical part of cell [GO:0045177]; axonal growth cone [GO:0044295]; caveola [GO:0005901]; ciliary membrane [GO:0060170]; dendritic growth cone [GO:0044294]; endocytic vesicle membrane [GO:0030666]; midbody [GO:0030496]; non-motile cilium membrane [GO:0098804]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0000122; GO:0001841; GO:0005113; GO:0005119; GO:0005886; GO:0005901; GO:0007165; GO:0007286; GO:0007420; GO:0008158; GO:0008201; GO:0008589; GO:0009410; GO:0009612; GO:0009887; GO:0009953; GO:0010875; GO:0015485; GO:0016485; GO:0021532; GO:0021997; GO:0030326; GO:0030332; GO:0030496; GO:0030666; GO:0030850; GO:0032355; GO:0032526; GO:0032880; GO:0035108; GO:0040015; GO:0043279; GO:0044294; GO:0044295; GO:0044877; GO:0045177; GO:0045211; GO:0045668; GO:0045879; GO:0045893; GO:0048471; GO:0048745; GO:0051782; GO:0060037; GO:0060170; GO:0061053; GO:0071397; GO:0071679; GO:0072205; GO:0072659; GO:0097108; GO:0097421; GO:0098804; GO:0140303
GN011105	GN011105.1	P55072	87.8	803	800	806	0.0	1391	TERA_HUMAN	Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)	Homo sapiens (Human)	ATP metabolic process [GO:0046034]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to arsenite ion [GO:1903843]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; cytoplasm protein quality control [GO:0140455]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; endoplasmic reticulum stress-induced pre-emptive quality control [GO:0061857]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endoplasmic reticulum unfolded protein response [GO:0030968]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ERAD pathway [GO:0036503]; establishment of protein localization [GO:0045184]; flavin adenine dinucleotide catabolic process [GO:0072389]; interstrand cross-link repair [GO:0036297]; macroautophagy [GO:0016236]; mitophagy [GO:0000423]; mitotic spindle disassembly [GO:0051228]; NAD+ metabolic process [GO:0019674]; negative regulation of hippo signaling [GO:0035331]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of smoothened signaling pathway [GO:0045879]; peptidyl-lysine trimethylation [GO:0018023]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; positive regulation of protein-containing complex assembly [GO:0031334]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; protein unfolding [GO:0043335]; protein-DNA covalent cross-linking repair [GO:0106300]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of protein localization to chromatin [GO:1905634]; regulation of synapse organization [GO:0050807]; rescue of stalled cytosolic ribosome [GO:0072344]; retrograde protein transport, ER to cytosol [GO:0030970]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]; stress granule disassembly [GO:0035617]; translesion synthesis [GO:0019985]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral genome replication [GO:0019079]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; BAT3 complex binding [GO:1904288]; deubiquitinase activator activity [GO:0035800]; identical protein binding [GO:0042802]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; MHC class I protein binding [GO:0042288]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-modified protein reader activity [GO:0140036]; ubiquitin-specific protease binding [GO:1990381]	ATPase complex [GO:1904949]; azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoplasmic ubiquitin ligase complex [GO:0000153]; cytosol [GO:0005829]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; intracellular protein-containing complex [GO:0140535]; lipid droplet [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991]; RQC complex [GO:1990112]; secretory granule lumen [GO:0034774]; site of double-strand break [GO:0035861]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; VCP-NSFL1C complex [GO:1990730]	GO:0000153; GO:0000423; GO:0000502; GO:0003723; GO:0005524; GO:0005576; GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005789; GO:0005811; GO:0005829; GO:0006281; GO:0006302; GO:0006511; GO:0006888; GO:0006914; GO:0006974; GO:0010494; GO:0010498; GO:0010918; GO:0016236; GO:0016567; GO:0016887; GO:0018023; GO:0019079; GO:0019674; GO:0019903; GO:0019904; GO:0019985; GO:0030968; GO:0030970; GO:0031334; GO:0031593; GO:0031625; GO:0032436; GO:0032510; GO:0032991; GO:0034098; GO:0034605; GO:0034774; GO:0035331; GO:0035578; GO:0035617; GO:0035800; GO:0035861; GO:0036297; GO:0036435; GO:0036503; GO:0036513; GO:0042288; GO:0042802; GO:0042981; GO:0043161; GO:0043231; GO:0043335; GO:0043531; GO:0044389; GO:0045184; GO:0045732; GO:0045879; GO:0046034; GO:0048471; GO:0050807; GO:0051228; GO:0061857; GO:0070062; GO:0071218; GO:0072344; GO:0072389; GO:0090263; GO:0097352; GO:0098978; GO:0106300; GO:0120186; GO:0140036; GO:0140455; GO:0140535; GO:1901224; GO:1903006; GO:1903715; GO:1903843; GO:1903862; GO:1904288; GO:1904813; GO:1904949; GO:1905634; GO:1990112; GO:1990116; GO:1990381; GO:1990730; GO:2001171
GN011106	GN011106.1	Q6AXK4	40.3	231	291	370	1.70e-53	181	BABA1_DANRE	BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212]		BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0006302; GO:0007095; GO:0010212; GO:0016604; GO:0045739; GO:0070531; GO:0070552; GO:0140861
GN011107	GN011107.1	Q4ZIN3	57.9	506	835	620	8.87e-174	518	MBRL_HUMAN	Membralin (Transmembrane protein 259)	Homo sapiens (Human)	positive regulation of ERAD pathway [GO:1904294]; response to endoplasmic reticulum stress [GO:0034976]		endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0034976; GO:1904294
GN011108	GN011108.1	Q8TCT0	38.2	186	468	537	1.88e-29	124	CERK1_HUMAN	Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4)	Homo sapiens (Human)	ceramide metabolic process [GO:0006672]; glycosphingolipid biosynthetic process [GO:0006688]	ceramide kinase activity [GO:0001729]; magnesium ion binding [GO:0000287]	cytoplasm [GO:0005737]; cytoplasmic side of trans-Golgi network membrane [GO:0160281]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0000287; GO:0001729; GO:0005737; GO:0005886; GO:0006672; GO:0006688; GO:0016020; GO:0160281
GN011109	GN011109.1	Q9GRC0	48.9	270	316	351	1.09e-76	241	MOS_PATPE	Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos)	Patiria pectinifera (Starfish) (Asterina pectinifera)	female gamete generation [GO:0007292]; female meiosis II [GO:0007147]; negative regulation of mitotic cell cycle [GO:0045930]	ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; protein serine kinase activity [GO:0106310]		GO:0004709; GO:0005524; GO:0007147; GO:0007292; GO:0045930; GO:0106310
GN011110	GN011110.1	O15400	38.5	260	281	261	1.09e-39	142	STX7_HUMAN	Syntaxin-7	Homo sapiens (Human)	intracellular protein transport [GO:0006886]; organelle assembly [GO:0070925]; organelle localization [GO:0051640]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]	chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]	azurophil granule [GO:0042582]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; tertiary granule [GO:0070820]; vesicle [GO:0031982]	GO:0000149; GO:0001772; GO:0001916; GO:0005484; GO:0005764; GO:0005765; GO:0005768; GO:0005769; GO:0005770; GO:0005886; GO:0006886; GO:0008021; GO:0019869; GO:0019905; GO:0030139; GO:0031901; GO:0031982; GO:0042582; GO:0048278; GO:0048471; GO:0051640; GO:0055037; GO:0070062; GO:0070820; GO:0070925; GO:1902685; GO:1903076
GN011116	GN011116.1	Q5F339	71.9	192	286	273	2.08e-97	290	CCHL_CHICK	Holocytochrome c-type synthase (EC 4.4.1.17) (Cytochrome c-type heme lyase) (CCHL)	Gallus gallus (Chicken)		holocytochrome-c synthase activity [GO:0004408]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0004408; GO:0005739; GO:0005743
GN011118	GN011118.1	Q9Z0Z3	29.5	319	321	424	3.82e-40	148	SKP2_MOUSE	S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/WD-40 protein 1) (FWD1)	Mus musculus (Mouse)	defense response to virus [GO:0051607]; DNA double-strand break processing [GO:0000729]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; innate immune response [GO:0045087]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of smooth muscle cell proliferation [GO:0048661]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein localization to site of double-strand break [GO:1990166]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; ubiquitin-dependent protein catabolic process [GO:0006511]	identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0000082; GO:0000086; GO:0000209; GO:0000729; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0019005; GO:0033148; GO:0042802; GO:0042981; GO:0043161; GO:0045087; GO:0048661; GO:0051607; GO:0051726; GO:0070534; GO:0070936; GO:1902916; GO:1905168; GO:1990166; GO:1990756
GN011120	GN011120.1	Q13309	34.6	104	107	424	1.02e-12	65.9	SKP2_HUMAN	S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)	Homo sapiens (Human)	defense response to virus [GO:0051607]; G1/S transition of mitotic cell cycle [GO:0000082]; innate immune response [GO:0045087]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptotic process [GO:0042981]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0000082; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0019005; GO:0031146; GO:0042802; GO:0042981; GO:0043161; GO:0045087; GO:0051607; GO:0070534; GO:0070936; GO:1905168; GO:1990756
GN011121	GN011121.1	Q13309	34.6	104	107	424	1.39e-12	65.5	SKP2_HUMAN	S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)	Homo sapiens (Human)	defense response to virus [GO:0051607]; G1/S transition of mitotic cell cycle [GO:0000082]; innate immune response [GO:0045087]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptotic process [GO:0042981]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0000082; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0019005; GO:0031146; GO:0042802; GO:0042981; GO:0043161; GO:0045087; GO:0051607; GO:0070534; GO:0070936; GO:1905168; GO:1990756
GN011122	GN011122.1	P08953	42.4	165	521	1097	2.27e-24	111	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN011125	GN011125.1	Q504Y0	33.4	389	983	691	3.00e-48	187	S39AC_HUMAN	Zinc transporter ZIP12 (LIV-1 subfamily of ZIP zinc transporter 8) (LZT-Hs8) (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12)	Homo sapiens (Human)	intracellular monoatomic cation homeostasis [GO:0030003]; neural tube formation [GO:0001841]; neuron projection extension [GO:1990138]; zinc ion import across plasma membrane [GO:0071578]	monoatomic cation:bicarbonate symporter activity [GO:0140410]; zinc ion transmembrane transporter activity [GO:0005385]	extracellular vesicle [GO:1903561]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001841; GO:0005385; GO:0005886; GO:0016020; GO:0030003; GO:0071578; GO:0140410; GO:1903561; GO:1990138
GN011126	GN011126.1	Q8WZ42	26.0	181	350	34350	1.42e-13	75.9	TITIN_HUMAN	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)	Homo sapiens (Human)	cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; positive regulation of gene expression [GO:0010628]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle contraction [GO:0003009]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941]	actin filament binding [GO:0051015]; actinin binding [GO:0042805]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; muscle alpha-actinin binding [GO:0051371]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; structural constituent of muscle [GO:0008307]; structural molecule activity conferring elasticity [GO:0097493]; telethonin binding [GO:0031433]	actin cytoskeleton [GO:0015629]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; I band [GO:0031674]; M band [GO:0031430]; striated muscle thin filament [GO:0005865]; titin-telethonin complex [GO:1990733]; Z disc [GO:0030018]	GO:0000794; GO:0002020; GO:0003009; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0010628; GO:0015629; GO:0019887; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042803; GO:0042805; GO:0045214; GO:0048769; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0055013; GO:0060048; GO:0070062; GO:0097493; GO:0106310; GO:0141163; GO:1990733
GN011127	GN011127.1	O77819	46.2	1355	1373	1354	0.0	1047	ROCK1_RABIT	Rho-associated protein kinase 1 (EC 2.7.11.39) (Corneal epithelial Rho-associated-Ser/Thr kinase 1) (HEBM1) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (cAMP-dependent protein kinase ROCK-I) (CePKA) (p160 ROCK-1) (p160ROCK)	Oryctolagus cuniculus (Rabbit)	actomyosin structure organization [GO:0031032]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; mitotic cytokinesis [GO:0000281]; myoblast migration [GO:0051451]; podocyte cell migration [GO:0090521]; positive regulation of focal adhesion assembly [GO:0051894]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of gene expression [GO:0010468]; regulation of microtubule cytoskeleton organization [GO:0070507]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; small GTPase binding [GO:0031267]	bleb [GO:0032059]; centriole [GO:0005814]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GO:0000139; GO:0000281; GO:0001726; GO:0004674; GO:0005524; GO:0005737; GO:0005814; GO:0005856; GO:0005886; GO:0007266; GO:0010468; GO:0010494; GO:0030027; GO:0030334; GO:0030866; GO:0031032; GO:0031267; GO:0032059; GO:0032956; GO:0048598; GO:0051451; GO:0051894; GO:0070507; GO:0071559; GO:0072518; GO:0090521; GO:0106310
GN011133	GN011133.1	Q96AJ9	46.3	82	98	217	6.17e-14	67.4	VTI1A_HUMAN	Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2)	Homo sapiens (Human)	autophagy [GO:0006914]; endocytic recycling [GO:0032456]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion with Golgi apparatus [GO:0048280]; voluntary musculoskeletal movement [GO:0050882]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]	GO:0000139; GO:0000149; GO:0005484; GO:0005768; GO:0005776; GO:0005789; GO:0005794; GO:0005829; GO:0006886; GO:0006888; GO:0006891; GO:0006896; GO:0006914; GO:0008021; GO:0012507; GO:0016236; GO:0030136; GO:0031201; GO:0031902; GO:0032456; GO:0032588; GO:0042147; GO:0043025; GO:0044306; GO:0048280; GO:0048471; GO:0050882
GN011134	GN011134.1	O49447	68.8	298	304	379	1.81e-135	391	ADT3_ARATH	ADP/ATP translocase 3, mitochondrial (ADP,ATP carrier protein 3) (Adenine nucleotide translocator 3) (ANT 3)	Arabidopsis thaliana (Mouse-ear cress)	mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; purine nucleotide transport [GO:0015865]; regulation of mitochondrial membrane permeability [GO:0046902]	ATP:ADP antiporter activity [GO:0005471]	chloroplast envelope [GO:0009941]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0005471; GO:0005739; GO:0005743; GO:0005757; GO:0005886; GO:0009941; GO:0015865; GO:0016020; GO:0046902; GO:0140021; GO:1990544
GN011135	GN011135.1	P29372	50.7	211	258	298	3.46e-63	202	3MG_HUMAN	DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase)	Homo sapiens (Human)	base-excision repair [GO:0006284]; depurination [GO:0045007]; DNA alkylation repair [GO:0006307]	alkylbase DNA N-glycosylase activity [GO:0003905]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]	cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0003677; GO:0003684; GO:0003905; GO:0005654; GO:0005739; GO:0005829; GO:0006284; GO:0006307; GO:0019104; GO:0042645; GO:0045007
GN011136	GN011136.1	Q58D56	79.9	364	364	364	2.60e-213	590	DRG2_BOVIN	Developmentally-regulated GTP-binding protein 2 (DRG-2) (Translation factor GTPase DRG2) (TRAFAC GTPase DRG2) (EC 3.6.5.-)	Bos taurus (Bovine)	cytoplasmic translation [GO:0002181]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0002181; GO:0003924; GO:0005525; GO:0005634; GO:0005737
GN011137	GN011137.1	A3KMZ6	58.0	200	476	282	2.71e-71	230	COX11_BOVIN	Cytochrome c oxidase assembly protein COX11, mitochondrial	Bos taurus (Bovine)	ATP biosynthetic process [GO:0006754]; intracellular monoatomic cation homeostasis [GO:0030003]; mitochondrial respiratory chain complex IV assembly [GO:0033617]	copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]	mitochondrial inner membrane [GO:0005743]; protein-containing complex [GO:0032991]	GO:0005507; GO:0005743; GO:0006754; GO:0016531; GO:0030003; GO:0032991; GO:0033617
GN011146	GN011146.1	Q24524	41.2	493	499	512	1.26e-129	389	SING_DROME	Protein singed	Drosophila melanogaster (Fruit fly)	actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; antennal morphogenesis [GO:0048800]; cell migration [GO:0016477]; chaeta morphogenesis [GO:0008407]; cuticle pattern formation [GO:0035017]; dendrite development [GO:0016358]; epidermal cell differentiation [GO:0009913]; establishment or maintenance of cell polarity [GO:0007163]; filopodium assembly [GO:0046847]; hemocyte migration [GO:0035099]; imaginal disc-derived wing hair organization [GO:0035317]; microvillar actin bundle assembly [GO:0030034]; neuron projection morphogenesis [GO:0048812]; wound healing [GO:0042060]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; protein-macromolecule adaptor activity [GO:0030674]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]	GO:0003779; GO:0005737; GO:0007163; GO:0008407; GO:0009913; GO:0015629; GO:0016358; GO:0016477; GO:0030034; GO:0030036; GO:0030674; GO:0035017; GO:0035099; GO:0035317; GO:0042060; GO:0043005; GO:0043025; GO:0046847; GO:0048800; GO:0048812; GO:0051015; GO:0051017
GN011150	GN011150.1	Q9JIA7	30.9	635	623	617	4.51e-75	254	SPHK2_MOUSE	Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91)	Mus musculus (Mouse)	blood vessel development [GO:0001568]; brain development [GO:0007420]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; female pregnancy [GO:0007565]; intracellular signal transduction [GO:0035556]; negative regulation of cell growth [GO:0030308]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell activation involved in immune response [GO:0033008]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of ATP biosynthetic process [GO:2001169]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytochrome-c oxidase activity [GO:1904959]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; sphinganine-1-phosphate biosynthetic process [GO:0006669]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670]; transcription initiation-coupled chromatin remodeling [GO:0045815]	histone binding [GO:0042393]; sphingosine kinase activity [GO:0008481]; sphingosine-1-phosphate receptor activity [GO:0038036]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000786; GO:0001568; GO:0002720; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005743; GO:0005765; GO:0005783; GO:0005829; GO:0005886; GO:0006669; GO:0006670; GO:0007420; GO:0007565; GO:0008284; GO:0008481; GO:0016020; GO:0030308; GO:0032736; GO:0032755; GO:0032760; GO:0033008; GO:0035556; GO:0038036; GO:0042393; GO:0043065; GO:0043122; GO:0043306; GO:0045815; GO:0046512; GO:1903426; GO:1904628; GO:1904959; GO:2000304; GO:2001169
GN011151	GN011151.1	Q5ZIB2	25.0	1185	1378	1132	8.80e-16	87.0	FBF1_CHICK	Fas-binding factor 1 homolog (FBF-1)	Gallus gallus (Chicken)	apical junction assembly [GO:0043297]; cilium assembly [GO:0060271]; establishment of epithelial cell polarity [GO:0090162]		anchoring junction [GO:0070161]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition fiber [GO:0097539]; spindle pole [GO:0000922]	GO:0000922; GO:0005814; GO:0036064; GO:0043297; GO:0060271; GO:0070161; GO:0090162; GO:0097539
GN011152	GN011152.1	Q6DGQ8	69.7	198	207	217	5.21e-105	304	NDK5_DANRE	Nucleoside diphosphate kinase 5 (NDK5) (Putative 3'-5'-DNA exonuclease NDK5) (EC 3.1.11.-) (Radial spoke head protein 23 homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium movement [GO:0003341]; CTP biosynthetic process [GO:0006241]; DNA catabolic process [GO:0006308]; GTP biosynthetic process [GO:0006183]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; UTP biosynthetic process [GO:0006228]	3'-5'-DNA exonuclease activity [GO:0008296]	cilium [GO:0005929]	GO:0003341; GO:0005929; GO:0006183; GO:0006228; GO:0006241; GO:0006308; GO:0008296; GO:1902176
GN011153	GN011153.1	Q8NFT2	37.4	457	495	490	2.43e-84	271	STEA2_HUMAN	Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1)	Homo sapiens (Human)	copper ion import [GO:0015677]; endocytosis [GO:0006897]; Golgi to plasma membrane transport [GO:0006893]; regulated exocytosis [GO:0045055]; response to hormone [GO:0009725]	cupric reductase (NADH) activity [GO:0008823]; ferric-chelate reductase (NADPH) activity [GO:0052851]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network transport vesicle [GO:0030140]	GO:0000139; GO:0005768; GO:0005769; GO:0005829; GO:0005886; GO:0006893; GO:0006897; GO:0008823; GO:0009725; GO:0010008; GO:0015677; GO:0030140; GO:0045055; GO:0052851
GN011155	GN011155.1	P35980	75.9	187	188	188	3.20e-99	287	RL18_MOUSE	Large ribosomal subunit protein eL18 (60S ribosomal protein L18)	Mus musculus (Mouse)	cytoplasmic translation [GO:0002181]; negative regulation of myoblast fusion [GO:1901740]; spermatogenesis [GO:0007283]; striated muscle contraction [GO:0006941]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; rough endoplasmic reticulum [GO:0005791]; synapse [GO:0045202]	GO:0002181; GO:0003735; GO:0005730; GO:0005737; GO:0005783; GO:0005791; GO:0005829; GO:0006941; GO:0007283; GO:0022625; GO:0022626; GO:0045202; GO:1901740
GN011158	GN011158.1	Q3B8Q1	52.9	546	749	782	2.24e-189	561	DDX21_RAT	Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)	Rattus norvegicus (Rat)	positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of transcription by RNA polymerase III [GO:0045945]; R-loop processing [GO:0062176]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; transcription by RNA polymerase II [GO:0006366]	7SK snRNA binding [GO:0097322]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; RNA helicase activity [GO:0003724]; rRNA binding [GO:0019843]; snoRNA binding [GO:0030515]	B-WICH complex [GO:0110016]; chromosome [GO:0005694]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0002735; GO:0003724; GO:0003725; GO:0005524; GO:0005654; GO:0005694; GO:0005730; GO:0005739; GO:0005829; GO:0006366; GO:0009615; GO:0016887; GO:0019843; GO:0030515; GO:0035198; GO:0042802; GO:0043123; GO:0043330; GO:0045945; GO:0062176; GO:0097322; GO:0110016
GN011159	GN011159.1	P14316	47.1	121	223	349	2.17e-33	125	IRF2_HUMAN	Interferon regulatory factor 2 (IRF-2)	Homo sapiens (Human)	cell population proliferation [GO:0008283]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type I interferon production [GO:0032480]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 3 signaling pathway [GO:0034138]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	cell junction [GO:0030054]; chromatin [GO:0000785]; chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0001228; GO:0002376; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0006355; GO:0006357; GO:0008283; GO:0030054; GO:0032480; GO:0034138; GO:0043565; GO:0045944; GO:0051607; GO:1990837
GN011161	GN011161.1	Q13772	25.7	474	593	614	5.07e-16	85.1	NCOA4_HUMAN	Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1)	Homo sapiens (Human)	autophagy [GO:0006914]; cellular response to estrogen stimulus [GO:0071391]; cellular response to testosterone stimulus [GO:0071394]; erythrocyte differentiation [GO:0030218]; estrogen receptor signaling pathway [GO:0030520]; intracellular iron ion homeostasis [GO:0006879]; male gonad development [GO:0008584]; protein targeting to lysosome [GO:0006622]; response to hormone [GO:0009725]	transcription coactivator activity [GO:0003713]	autolysosome [GO:0044754]; autophagosome [GO:0005776]; chromosome [GO:0005694]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005694; GO:0005776; GO:0006622; GO:0006879; GO:0006914; GO:0008584; GO:0009725; GO:0030218; GO:0030520; GO:0044754; GO:0071391; GO:0071394
GN011163	GN011163.1	Q9UN19	47.2	233	249	280	1.01e-74	231	DAPP1_HUMAN	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa)	Homo sapiens (Human)	protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phospholipid binding [GO:0005543]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0005543; GO:0005547; GO:0005829; GO:0005886; GO:0006470; GO:0007165; GO:0043325
GN011165	GN011165.1	Q8WVB3	43.1	459	468	486	6.04e-118	357	HEXD_HUMAN	Hexosaminidase D (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase D) (Hexosaminidase domain-containing protein) (N-acetyl-beta-galactosaminidase)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]	beta-N-acetylhexosaminidase activity [GO:0004563]; hexosaminidase activity [GO:0015929]	cytoplasm [GO:0005737]; extracellular vesicle [GO:1903561]; nucleus [GO:0005634]	GO:0004563; GO:0005634; GO:0005737; GO:0005975; GO:0015929; GO:1903561
GN011167	GN011167.1	Q5ZHN9	44.5	481	499	557	9.82e-135	404	PGPS1_CHICK	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase 1) (PGP synthase 1)	Gallus gallus (Chicken)	cardiolipin biosynthetic process [GO:0032049]	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [GO:0008444]	mitochondrion [GO:0005739]	GO:0005739; GO:0008444; GO:0032049
GN011168	GN011168.1	P23098	73.0	4465	4464	4466	0.0	6655	DYHC_TRIGR	Dynein beta chain, ciliary	Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla)	microtubule-based movement [GO:0007018]	ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]	GO:0005524; GO:0005930; GO:0007018; GO:0008569; GO:0030286; GO:0045505; GO:0051959; GO:0097729
GN011169	GN011169.1	Q8NB15	37.0	100	157	252	8.56e-15	72.4	ZN511_HUMAN	Zinc finger protein 511	Homo sapiens (Human)		DNA-binding transcription factor activity [GO:0003700]	nucleus [GO:0005634]	GO:0003700; GO:0005634
GN011170	GN011170.1	D6WIX5	56.8	183	188	367	1.89e-66	210	MCU_TRICA	Calcium uniporter protein, mitochondrial (TcMCU)	Tribolium castaneum (Red flour beetle)	calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]	calcium channel activity [GO:0005262]	mitochondrial inner membrane [GO:0005743]; uniplex complex [GO:1990246]	GO:0005262; GO:0005743; GO:0036444; GO:0051560; GO:1990246
GN011171	GN011171.1	Q1JPX3	69.4	327	362	497	8.09e-168	480	SYFA_DANRE	Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)	Danio rerio (Zebrafish) (Brachydanio rerio)	phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; phenylalanine-tRNA ligase complex [GO:0009328]	GO:0000049; GO:0000287; GO:0004826; GO:0005524; GO:0005737; GO:0006432; GO:0009328; GO:0051290
GN011172	GN011172.1	Q5YCC5	34.6	641	954	735	1.37e-110	361	TMC7_CHICK	Transmembrane channel-like protein 7	Gallus gallus (Chicken)	sensory perception of mechanical stimulus [GO:0050954]	mechanosensitive monoatomic ion channel activity [GO:0008381]	plasma membrane [GO:0005886]	GO:0005886; GO:0008381; GO:0050954
GN011173	GN011173.1	P22031	37.5	104	254	105	3.02e-13	67.4	LEG_HELCR	D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL)	Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina)		carbohydrate binding [GO:0030246]	cytoplasm [GO:0005737]	GO:0005737; GO:0030246
GN011174	GN011174.1	E9PT23	42.3	400	768	1099	2.16e-88	304	S38AA_RAT	Solute carrier family 38 member 10 (Amino acid transporter SLC38A10)	Rattus norvegicus (Rat)	amino acid transmembrane transport [GO:0003333]; bone development [GO:0060348]	L-amino acid transmembrane transporter activity [GO:0015179]; monoatomic cation transmembrane transporter activity [GO:0008324]; neutral L-amino acid transmembrane transporter activity [GO:0015175]; secondary active transmembrane transporter activity [GO:0015291]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0003333; GO:0005794; GO:0008324; GO:0015175; GO:0015179; GO:0015291; GO:0016020; GO:0060348
GN011175	GN011175.1	C3YWU0	56.9	341	357	449	1.70e-149	432	FUCO_BRAFL	Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase)	Branchiostoma floridae (Florida lancelet) (Amphioxus)	fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]	alpha-L-fucosidase activity [GO:0004560]	extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0004560; GO:0005576; GO:0005764; GO:0006004; GO:0016139
GN011176	GN011176.1	Q5U2V4	53.3	456	486	550	6.91e-170	493	LYLAP_RAT	Lysosomal leucine aminopeptidase (LyLAP) (EC 3.4.11.-) (LAMA-like protein 1) (Lamina ancestor homolog 1) (Phospholipase B domain-containing protein 1) (Phospholipase B-like 1) [Cleaved into: Lysosomal leucine aminopeptidase chain A; Lysosomal leucine aminopeptidase chain B; Lysosomal leucine aminopeptidase chain C]	Rattus norvegicus (Rat)	lysosomal protein catabolic process [GO:1905146]	aminopeptidase activity [GO:0004177]; glycerophospholipase activity [GO:0004620]	extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0004177; GO:0004620; GO:0005576; GO:0005764; GO:1905146
GN011177	GN011177.1	Q02844	39.0	264	564	273	1.60e-47	170	TRYB1_MOUSE	Tryptase (EC 3.4.21.59) (Mast cell protease 7) (mMCP-7) (Tryptase alpha/beta-1)	Mus musculus (Mouse)	negative regulation of blood coagulation [GO:0030195]; proteolysis [GO:0006508]	identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]; mast cell granule [GO:0042629]; peptidase complex [GO:1905368]	GO:0004252; GO:0005576; GO:0006508; GO:0008233; GO:0030195; GO:0042629; GO:0042802; GO:1905368
GN011179	GN011179.1	A9XE49	64.5	200	198	200	2.16e-86	256	IL17L_MAGGI	Interleukin 17-like protein (CgIL-17)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		cytokine activity [GO:0005125]	extracellular region [GO:0005576]	GO:0005125; GO:0005576
GN011180	GN011180.1	A9XE49	66.2	157	155	200	1.76e-69	211	IL17L_MAGGI	Interleukin 17-like protein (CgIL-17)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		cytokine activity [GO:0005125]	extracellular region [GO:0005576]	GO:0005125; GO:0005576
GN011182	GN011182.1	A9XE49	67.5	157	155	200	1.52e-70	214	IL17L_MAGGI	Interleukin 17-like protein (CgIL-17)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		cytokine activity [GO:0005125]	extracellular region [GO:0005576]	GO:0005125; GO:0005576
GN011183	GN011183.1	A9XE49	66.0	188	220	200	8.25e-85	253	IL17L_MAGGI	Interleukin 17-like protein (CgIL-17)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		cytokine activity [GO:0005125]	extracellular region [GO:0005576]	GO:0005125; GO:0005576
GN011184	GN011184.1	A9XE49	66.2	157	159	200	2.52e-70	213	IL17L_MAGGI	Interleukin 17-like protein (CgIL-17)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		cytokine activity [GO:0005125]	extracellular region [GO:0005576]	GO:0005125; GO:0005576
GN011192	GN011192.1	Q2YDJ8	39.3	112	967	352	2.30e-13	76.3	KMT5A_BOVIN	N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.361) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8)	Bos taurus (Bovine)	negative regulation of transcription by RNA polymerase II [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279]	chromosome [GO:0005694]; nucleus [GO:0005634]; polytene chromosome [GO:0005700]	GO:0000122; GO:0005634; GO:0005694; GO:0005700; GO:0006357; GO:0016279; GO:0018026; GO:0042054; GO:0042799; GO:0043516; GO:0140944
GN011198	GN011198.1	Q9H9Y2	64.9	296	325	349	2.37e-134	388	RPF1_HUMAN	Ribosome production factor 1 (Brix domain-containing protein 5) (Ribosome biogenesis protein RPF1)	Homo sapiens (Human)	maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]	RNA binding [GO:0003723]; rRNA primary transcript binding [GO:0042134]	nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]	GO:0000460; GO:0000470; GO:0003723; GO:0005730; GO:0030687; GO:0042134
GN011199	GN011199.1	Q96GM8	38.0	511	495	510	4.57e-101	315	TOE1_HUMAN	Target of EGR1 protein 1	Homo sapiens (Human)	snRNA 3'-end processing [GO:0034472]	3'-5'-RNA exonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; snRNA binding [GO:0017069]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]	GO:0000175; GO:0004535; GO:0005730; GO:0005737; GO:0015030; GO:0016607; GO:0017069; GO:0034472; GO:0046872
GN011200	GN011200.1	A6QPA3	36.0	283	290	291	5.85e-57	187	BTBDJ_BOVIN	BTB/POZ domain-containing protein 19	Bos taurus (Bovine)				
GN011201	GN011201.1	Q9V9S7	32.4	1008	1019	1866	1.97e-110	380	SYDE_DROME	Rho GTPase-activating protein 100F (RhoGAP-100F) (Synapse defective protein 1 homolog) (Protein syd-1 homolog)	Drosophila melanogaster (Fruit fly)	activation of GTPase activity [GO:0090630]; axon extension involved in axon guidance [GO:0048846]; cell migration [GO:0016477]; cytoskeletal matrix organization at active zone [GO:0048789]; maintenance of presynaptic active zone structure [GO:0048790]; presynaptic active zone organization [GO:1990709]; R7 cell development [GO:0045467]; regulation of Ras protein signal transduction [GO:0046578]; Rho protein signal transduction [GO:0007266]; synapse assembly [GO:0007416]; synaptic vesicle localization [GO:0097479]	GTPase activator activity [GO:0005096]	neuromuscular junction [GO:0031594]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; synaptic membrane [GO:0097060]	GO:0005096; GO:0007266; GO:0007416; GO:0016477; GO:0031594; GO:0045467; GO:0046578; GO:0048786; GO:0048789; GO:0048790; GO:0048846; GO:0090630; GO:0097060; GO:0097479; GO:0098793; GO:0098831; GO:1990709
GN011204	GN011204.1	P17972	39.6	432	587	498	4.01e-95	303	KCNAW_DROME	Potassium voltage-gated channel protein Shaw (Shaw2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431]	delayed rectifier potassium channel activity [GO:0005251]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated potassium channel activity [GO:0005249]	axon terminus [GO:0043679]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0032590; GO:0032809; GO:0042734; GO:0043679; GO:0045211; GO:0051260; GO:0071805
GN011209	GN011209.1	Q9UGU5	40.5	227	786	601	1.23e-37	152	HMGX4_HUMAN	HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG)	Homo sapiens (Human)	endosome to lysosome transport [GO:0008333]; negative regulation of Wnt signaling pathway [GO:0030178]	identical protein binding [GO:0042802]	NURF complex [GO:0016589]	GO:0008333; GO:0016589; GO:0030178; GO:0042802
GN011210	GN011210.1	P54319	48.1	794	787	795	1.57e-163	496	PLAP_RAT	Phospholipase A-2-activating protein (PLA2P) (PLAP)	Rattus norvegicus (Rat)	cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; macroautophagy [GO:0016236]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; positive regulation of dendrite extension [GO:1903861]; positive regulation of neuron migration [GO:2001224]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of synaptic vesicle recycling [GO:1903423]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin recycling [GO:0010992]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	phospholipase A2 activator activity [GO:0016005]; ubiquitin binding [GO:0043130]	ATPase complex [GO:1904949]; cytoplasm [GO:0005737]; cytoplasmic ubiquitin ligase complex [GO:0000153]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0000153; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006954; GO:0010992; GO:0016005; GO:0016236; GO:0031394; GO:0043130; GO:0043161; GO:0043162; GO:0045202; GO:0070062; GO:0071222; GO:1900045; GO:1903423; GO:1903861; GO:1904949; GO:2001224
GN011213	GN011213.1	B5X4E0	40.4	275	323	316	4.41e-53	179	CALUB_SALSA	Calumenin-B	Salmo salar (Atlantic salmon)		calcium ion binding [GO:0005509]	endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; sarcoplasmic reticulum lumen [GO:0033018]	GO:0005509; GO:0005576; GO:0005789; GO:0005794; GO:0033018; GO:0042470
GN011214	GN011214.1	Q99LH1	51.4	722	691	728	8.91e-215	622	NOG2_MOUSE	Nucleolar GTP-binding protein 2	Mus musculus (Mouse)		GTP binding [GO:0005525]	nucleolus [GO:0005730]	GO:0005525; GO:0005730
GN011215	GN011215.1	P13508	31.6	209	955	1295	2.19e-11	72.0	GLP1_CAEEL	Protein glp-1 [Cleaved into: glp-1/Notch intracellular domain]	Caenorhabditis elegans	cell fate specification [GO:0001708]; cellularization [GO:0007349]; cytoplasmic streaming [GO:0099636]; embryonic pattern specification [GO:0009880]; maintenance of dauer [GO:0043055]; negative regulation of stem cell differentiation [GO:2000737]; nematode larval development [GO:0002119]; nematode pharyngeal muscle development [GO:0160096]; Notch signaling pathway [GO:0007219]; oocyte growth [GO:0001555]; positive regulation of gene expression [GO:0010628]; positive regulation of germ cell proliferation [GO:1905938]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of gene expression [GO:0010468]; regulation of germ cell proliferation [GO:1905936]; regulation of transcription by RNA polymerase II [GO:0006357]	calcium ion binding [GO:0005509]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transmembrane signaling receptor activity [GO:0004888]	axon [GO:0030424]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; lateral plasma membrane [GO:0016328]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0001555; GO:0001708; GO:0002119; GO:0003713; GO:0004888; GO:0005509; GO:0005634; GO:0005737; GO:0005886; GO:0006357; GO:0007219; GO:0007349; GO:0009880; GO:0010468; GO:0010608; GO:0010628; GO:0012505; GO:0016328; GO:0030424; GO:0043055; GO:0045944; GO:0061629; GO:0090575; GO:0099636; GO:0160096; GO:1905936; GO:1905938; GO:2000648; GO:2000737
GN011217	GN011217.1	Q3MI03	47.7	488	506	542	6.54e-142	422	OGFD1_BOVIN	Prolyl 3-hydroxylase OGFOD1 (EC 1.14.11.-) (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) (uS12 prolyl 3-hydroxylase)	Bos taurus (Bovine)	cell population proliferation [GO:0008283]; protein hydroxylation [GO:0018126]; regulation of translational termination [GO:0006449]; stress granule assembly [GO:0034063]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 3-dioxygenase activity [GO:0031544]; peptidyl-proline dioxygenase activity [GO:0031543]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]	GO:0005506; GO:0005634; GO:0005737; GO:0006449; GO:0008283; GO:0010494; GO:0018126; GO:0031418; GO:0031543; GO:0031544; GO:0034063
GN011218	GN011218.1	Q9NXG6	34.9	355	408	502	3.73e-56	195	P4HTM_HUMAN	Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4)	Homo sapiens (Human)	regulation of erythrocyte differentiation [GO:0045646]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; calcium ion binding [GO:0005509]; hypoxia-inducible factor-proline dioxygenase activity [GO:0160082]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]	endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005509; GO:0005789; GO:0016706; GO:0031418; GO:0045646; GO:0160082
GN011219	GN011219.1	O14901	59.7	62	354	512	1.96e-13	74.7	KLF11_HUMAN	Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2)	Homo sapiens (Human)	cellular response to endothelin [GO:1990859]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000976; GO:0000978; GO:0000981; GO:0003700; GO:0005634; GO:0005654; GO:0006357; GO:0008285; GO:0043065; GO:1990837; GO:1990859; GO:2000045
GN011221	GN011221.1	O89091	59.0	61	414	479	3.04e-11	68.6	KLF10_MOUSE	Krueppel-like factor 10 (GDNF-inducible factor) (Transcription factor GIF) (mGIF) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1)	Mus musculus (Mouse)	bone mineralization [GO:0030282]; cellular response to starvation [GO:0009267]; circadian rhythm [GO:0007623]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]	core promoter sequence-specific DNA binding [GO:0001046]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001046; GO:0001228; GO:0003677; GO:0005634; GO:0006355; GO:0006357; GO:0007623; GO:0009267; GO:0030282; GO:0035019; GO:0042752; GO:0045672; GO:0045892; GO:0045944; GO:1990837
GN011223	GN011223.1	Q15262	35.5	561	840	1439	1.01e-96	333	PTPRK_HUMAN	Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)	Homo sapiens (Human)	cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]	beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; organelle [GO:0043226]; plasma membrane [GO:0005886]	GO:0004725; GO:0005001; GO:0005886; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016020; GO:0016477; GO:0019901; GO:0030054; GO:0030336; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043226; GO:0045295; GO:0045786; GO:0045892; GO:0048041
GN011224	GN011224.1	Q8MJ08	36.0	214	276	492	4.33e-28	115	PE2R4_BOVIN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0007188; GO:0007189; GO:0007204; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN011225	GN011225.1	P32240	31.1	399	360	513	5.41e-37	142	PE2R4_MOUSE	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0000165; GO:0001818; GO:0001819; GO:0002792; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0008284; GO:0009624; GO:0010628; GO:0010840; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0071260; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1904496; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN011226	GN011226.1	Q28691	33.6	318	384	488	1.06e-43	161	PE2R4_RABIT	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Oryctolagus cuniculus (Rabbit)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to mechanical stimulus [GO:0009612]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0001818; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0009612; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN011227	GN011227.1	P43114	33.2	331	351	488	3.25e-45	164	PE2R4_RAT	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Rattus norvegicus (Rat)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to glucose stimulus [GO:0071333]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nematode [GO:0009624]; response to progesterone [GO:0032570]; response to prostaglandin E [GO:0034695]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; response to xenobiotic stimulus [GO:0009410]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009410; GO:0009612; GO:0009624; GO:0010628; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032570; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060135; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0070555; GO:0071260; GO:0071333; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1902074; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1990785; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN011228	GN011228.1	Q95KZ0	32.5	317	353	490	9.69e-44	160	PE2R4_PANTR	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Pan troglodytes (Chimpanzee)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to mechanical stimulus [GO:0009612]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0009612; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN011230	GN011230.1	Q28691	38.1	189	269	488	1.76e-34	132	PE2R4_RABIT	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Oryctolagus cuniculus (Rabbit)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to mechanical stimulus [GO:0009612]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0001818; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0009612; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN011232	GN011232.1	P32240	32.2	395	368	513	7.68e-46	167	PE2R4_MOUSE	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0000165; GO:0001818; GO:0001819; GO:0002792; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0008284; GO:0009624; GO:0010628; GO:0010840; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0071260; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1904496; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN011233	GN011233.1	Q95KZ0	32.5	317	353	490	9.69e-44	160	PE2R4_PANTR	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Pan troglodytes (Chimpanzee)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to mechanical stimulus [GO:0009612]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0009612; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN011235	GN011235.1	Q28691	38.1	189	269	488	1.76e-34	132	PE2R4_RABIT	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Oryctolagus cuniculus (Rabbit)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to mechanical stimulus [GO:0009612]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0001818; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0009612; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN011237	GN011237.1	P32240	32.2	395	368	513	7.68e-46	167	PE2R4_MOUSE	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0000165; GO:0001818; GO:0001819; GO:0002792; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0008284; GO:0009624; GO:0010628; GO:0010840; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0071260; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1904496; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN011238	GN011238.1	Q95KZ0	32.5	317	353	490	9.69e-44	160	PE2R4_PANTR	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Pan troglodytes (Chimpanzee)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to mechanical stimulus [GO:0009612]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0009612; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN011240	GN011240.1	Q28691	38.1	189	269	488	1.27e-34	133	PE2R4_RABIT	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Oryctolagus cuniculus (Rabbit)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to mechanical stimulus [GO:0009612]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0001818; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0009612; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN011242	GN011242.1	P32240	32.2	395	368	513	7.68e-46	167	PE2R4_MOUSE	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0000165; GO:0001818; GO:0001819; GO:0002792; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0008284; GO:0009624; GO:0010628; GO:0010840; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0071260; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1904496; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN011243	GN011243.1	Q95KZ0	32.5	317	371	490	1.54e-43	160	PE2R4_PANTR	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Pan troglodytes (Chimpanzee)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to mechanical stimulus [GO:0009612]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0009612; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN011245	GN011245.1	Q28691	38.1	189	269	488	1.76e-34	132	PE2R4_RABIT	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Oryctolagus cuniculus (Rabbit)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to mechanical stimulus [GO:0009612]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0001818; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0009612; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN011247	GN011247.1	P32240	31.1	405	383	513	4.16e-43	160	PE2R4_MOUSE	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0000165; GO:0001818; GO:0001819; GO:0002792; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0008284; GO:0009624; GO:0010628; GO:0010840; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0071260; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1904496; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN011248	GN011248.1	Q95KZ0	32.2	317	371	490	5.74e-43	159	PE2R4_PANTR	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Pan troglodytes (Chimpanzee)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to mechanical stimulus [GO:0009612]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0009612; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN011250	GN011250.1	Q80Z37	39.4	132	715	1033	4.64e-18	92.8	TOPRS_MOUSE	E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; maintenance of protein location in nucleus [GO:0051457]; positive regulation of DNA-templated transcription [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein localization to nucleus [GO:0034504]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein sumoylation [GO:0016925]; regulation of cell population proliferation [GO:0042127]; ubiquitin-dependent protein catabolic process [GO:0006511]	antigen binding [GO:0003823]; DNA binding [GO:0003677]; DNA topoisomerase binding [GO:0044547]; metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	centriole [GO:0005814]; ciliary basal body [GO:0036064]; gamma-tubulin complex [GO:0000930]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; PML body [GO:0016605]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000209; GO:0000922; GO:0000930; GO:0003677; GO:0003823; GO:0004842; GO:0005634; GO:0005654; GO:0005814; GO:0006511; GO:0006513; GO:0006974; GO:0008630; GO:0016605; GO:0016607; GO:0016925; GO:0019789; GO:0032391; GO:0034504; GO:0036064; GO:0042127; GO:0042771; GO:0043161; GO:0044547; GO:0045893; GO:0046872; GO:0051457; GO:0061630; GO:0070936
GN011253	GN011253.1	P55202	66.7	63	64	1050	7.25e-21	87.0	ANPRB_ANGJA	Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B)	Anguilla japonica (Japanese eel)	intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]	adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; protein kinase activity [GO:0004672]	plasma membrane [GO:0005886]	GO:0004016; GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0007168; GO:0016941; GO:0017046; GO:0035556
GN011258	GN011258.1	P35408	34.2	316	373	488	4.84e-35	137	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of stress fiber assembly [GO:0051492]; response to mechanical stimulus [GO:0009612]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0009612; GO:0016020; GO:0033624; GO:0034695; GO:0042093; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070371; GO:0071260; GO:0071380; GO:2000420
GN011259	GN011259.1	P41233	44.3	2398	2403	2261	0.0	1807	ABCA1_MOUSE	Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cholesterol [GO:0071397]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endosomal transport [GO:0016197]; export across plasma membrane [GO:0140115]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein metabolic process [GO:0042157]; lysosome organization [GO:0007040]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; phospholipid transport [GO:0015914]; platelet dense granule organization [GO:0060155]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; protein lipidation [GO:0006497]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; regulation of Cdc42 protein signal transduction [GO:0032489]; response to laminar fluid shear stress [GO:0034616]; response to vitamin B3 [GO:0033552]; reverse cholesterol transport [GO:0043691]; signal release [GO:0023061]	ABC-type transporter activity [GO:0140359]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein A-I receptor activity [GO:0034188]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; high-density lipoprotein particle binding [GO:0008035]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transfer activity [GO:0120014]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; sphingolipid floppase activity [GO:0046623]; syntaxin binding [GO:0019905]; transmembrane protein transporter activity [GO:0008320]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	GO:0002790; GO:0005102; GO:0005524; GO:0005768; GO:0005794; GO:0005886; GO:0006497; GO:0006911; GO:0007040; GO:0007186; GO:0007189; GO:0008035; GO:0008203; GO:0008320; GO:0009306; GO:0009897; GO:0009986; GO:0010875; GO:0015914; GO:0016197; GO:0016323; GO:0016887; GO:0019905; GO:0023061; GO:0030139; GO:0030301; GO:0031210; GO:0031267; GO:0032367; GO:0032489; GO:0033344; GO:0033552; GO:0033700; GO:0034185; GO:0034186; GO:0034188; GO:0034380; GO:0034616; GO:0042157; GO:0042158; GO:0042626; GO:0042632; GO:0043691; GO:0045121; GO:0045332; GO:0045335; GO:0046623; GO:0048471; GO:0051117; GO:0055091; GO:0060155; GO:0071222; GO:0071300; GO:0071345; GO:0071397; GO:0071466; GO:0071806; GO:0090108; GO:0090554; GO:0090556; GO:0097708; GO:0120014; GO:0120020; GO:0140115; GO:0140326; GO:0140328; GO:0140359
GN011263	GN011263.1	O89044	60.3	156	168	507	3.28e-59	194	PRI2_RAT	DNA primase large subunit (DNA primase 58 kDa subunit) (p58)	Rattus norvegicus (Rat)	DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of primer [GO:0006269]	4 iron, 4 sulfur cluster binding [GO:0051539]; DNA-directed RNA polymerase activity [GO:0003899]; DNA/RNA hybrid binding [GO:0071667]	alpha DNA polymerase:primase complex [GO:0005658]; nucleoplasm [GO:0005654]	GO:0003899; GO:0005654; GO:0005658; GO:0006260; GO:0006269; GO:0006270; GO:0051539; GO:0071667
GN011264	GN011264.1	Q4VBE8	39.8	437	504	431	2.02e-99	309	WDR18_MOUSE	WD repeat-containing protein 18	Mus musculus (Mouse)	DNA-templated DNA replication [GO:0006261]; rRNA processing [GO:0006364]		cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293]; nuclear pre-replicative complex [GO:0005656]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; rixosome complex [GO:0120330]	GO:0005634; GO:0005654; GO:0005656; GO:0005730; GO:0005737; GO:0006261; GO:0006364; GO:0120293; GO:0120330
GN011269	GN011269.1	A7RM45	44.8	547	534	546	1.00e-149	443	LMBD1_NEMVE	Probable lysosomal cobalamin transporter	Nematostella vectensis (Starlet sea anemone)	protein localization to vacuole [GO:0072665]		lysosomal membrane [GO:0005765]; vacuolar membrane [GO:0005774]	GO:0005765; GO:0005774; GO:0072665
GN011271	GN011271.1	P50876	54.4	294	300	292	5.49e-113	331	R144A_HUMAN	E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4)	Homo sapiens (Human)	pattern recognition receptor signaling pathway [GO:0002221]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0002221; GO:0005789; GO:0005794; GO:0005886; GO:0008270; GO:0010008; GO:0016567; GO:0030659; GO:0031624; GO:0061630; GO:0085020
GN011272	GN011272.1	Q7TNV0	60.5	342	418	380	4.40e-38	144	DEK_MOUSE	Protein DEK	Mus musculus (Mouse)	chromatin remodeling [GO:0006338]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of double-strand break repair [GO:2000779]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]	DNA binding [GO:0003677]; histone binding [GO:0042393]	B-WICH complex [GO:0110016]; contractile muscle fiber [GO:0043292]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0005654; GO:0005730; GO:0006338; GO:0042393; GO:0043292; GO:0045943; GO:0045944; GO:0045945; GO:0110016; GO:2000779; GO:2001032
GN011274	GN011274.1	P07201	76.7	391	429	384	1.13e-210	587	RIR2_SPISO	Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small subunit) (p41)	Spisula solidissima (Atlantic surf-clam)	deoxyribonucleotide biosynthetic process [GO:0009263]	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]	cytosol [GO:0005829]	GO:0004748; GO:0005829; GO:0009263
GN011275	GN011275.1	P50876	54.4	294	300	292	5.49e-113	331	R144A_HUMAN	E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4)	Homo sapiens (Human)	pattern recognition receptor signaling pathway [GO:0002221]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0002221; GO:0005789; GO:0005794; GO:0005886; GO:0008270; GO:0010008; GO:0016567; GO:0030659; GO:0031624; GO:0061630; GO:0085020
GN011276	GN011276.1	O43324	45.4	97	104	174	6.50e-19	79.7	MCA3_HUMAN	Eukaryotic translation elongation factor 1 epsilon-1 (Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3) (Elongation factor p18) (Multisynthase complex auxiliary component p18)	Homo sapiens (Human)	negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cellular senescence [GO:2000774]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; tRNA aminoacylation for protein translation [GO:0006418]		aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006418; GO:0008285; GO:0017101; GO:0043065; GO:0043517; GO:2000774
GN011277	GN011277.1	O60683	34.1	232	225	326	3.48e-40	143	PEX10_HUMAN	Peroxisome biogenesis factor 10 (EC 2.3.2.27) (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69)	Homo sapiens (Human)	cellular response to reactive oxygen species [GO:0034614]; peroxisome organization [GO:0007031]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, receptor recycling [GO:0016562]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]	transmembrane protein transporter activity [GO:0008320]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000209; GO:0005777; GO:0005778; GO:0006515; GO:0007031; GO:0008270; GO:0008320; GO:0016558; GO:0016562; GO:0034614; GO:0043161; GO:0044721; GO:0061630
GN011278	GN011278.1	G3GTP0	48.8	907	915	912	1.02e-301	859	DNLI4_CRIGR	DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	base-excision repair [GO:0006284]; cellular response to ionizing radiation [GO:0071479]; DNA biosynthetic process [GO:0071897]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; immunoglobulin V(D)J recombination [GO:0033152]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of chromosome organization [GO:2001252]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]; magnesium ion binding [GO:0000287]	condensed chromosome [GO:0000793]; DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000012; GO:0000287; GO:0000793; GO:0003677; GO:0003910; GO:0005524; GO:0005634; GO:0005654; GO:0005958; GO:0006284; GO:0006297; GO:0010165; GO:0032807; GO:0033152; GO:0071479; GO:0071897; GO:0097680; GO:2001252
GN011279	GN011279.1	E9QBI7	39.0	272	309	478	1.02e-64	214	OMA1_DANRE	Metalloendopeptidase OMA1, mitochondrial (zfoma1) (EC 3.4.24.-) (Overlapping with the m-AAA protease 1 homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	diet induced thermogenesis [GO:0002024]; energy homeostasis [GO:0097009]; glucose metabolic process [GO:0006006]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; lipid metabolic process [GO:0006629]; mitochondrial protein processing [GO:0034982]; mitochondrial respiratory chain complex assembly [GO:0033108]; negative regulation of mitochondrial fusion [GO:0010637]; positive regulation of apoptotic process [GO:0043065]; protein autoprocessing [GO:0016540]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of cristae formation [GO:1903850]; zymogen activation [GO:0031638]	metalloendopeptidase activity [GO:0004222]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]	GO:0002024; GO:0004222; GO:0005743; GO:0006006; GO:0006515; GO:0006629; GO:0010637; GO:0016540; GO:0031638; GO:0031966; GO:0033108; GO:0034982; GO:0043065; GO:0097009; GO:0140467; GO:0140468; GO:1903850
GN011280	GN011280.1	P07560	30.4	171	200	215	5.21e-28	107	SEC4_YEAST	Ras-related protein SEC4 (Suppressor of RHO3 protein 6)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	ascospore-type prospore assembly [GO:0031321]; autophagy [GO:0006914]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane addition at site of cytokinesis [GO:0007107]; vesicle fusion [GO:0006906]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cellular bud neck [GO:0005935]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; incipient cellular bud site [GO:0000131]; mating projection tip [GO:0043332]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; transport vesicle membrane [GO:0030658]; vesicle [GO:0031982]	GO:0000131; GO:0003924; GO:0005525; GO:0005739; GO:0005741; GO:0005768; GO:0005783; GO:0005886; GO:0005935; GO:0006887; GO:0006893; GO:0006906; GO:0006914; GO:0007107; GO:0030133; GO:0030658; GO:0031321; GO:0031982; GO:0043332
GN011281	GN011281.1	P61593	48.7	115	287	835	2.56e-22	100	MCPH1_PANTR	Microcephalin	Pan troglodytes (Chimpanzee)	cerebral cortex development [GO:0021987]; mitotic cell cycle [GO:0000278]; regulation of gene expression [GO:0010468]		centrosome [GO:0005813]	GO:0000278; GO:0005813; GO:0010468; GO:0021987
GN011282	GN011282.1	P61590	43.2	185	577	841	1.21e-35	146	MCPH1_COLGU	Microcephalin	Colobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey)	cerebral cortex development [GO:0021987]; mitotic cell cycle [GO:0000278]; regulation of gene expression [GO:0010468]		centrosome [GO:0005813]	GO:0000278; GO:0005813; GO:0010468; GO:0021987
GN011283	GN011283.1	Q684M2	44.8	357	515	469	1.09e-96	303	ATG4D_PIG	Cysteine protease ATG4D (EC 3.4.22.-) (Autophagy-related protein 4 homolog D) (Autophagin-4) [Cleaved into: Cysteine protease ATG4D, mitochondrial]	Sus scrofa (Pig)	aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; protein delipidation [GO:0051697]; protein localization to phagophore assembly site [GO:0034497]; protein processing [GO:0016485]	cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]	GO:0000045; GO:0000423; GO:0004197; GO:0005737; GO:0005759; GO:0006914; GO:0008234; GO:0016485; GO:0019786; GO:0034497; GO:0034727; GO:0035973; GO:0051697
GN011284	GN011284.1	Q68EP9	45.5	66	103	450	3.62e-16	75.5	ATG4C_XENTR	Cysteine protease ATG4C (EC 3.4.22.-) (Autophagy-related protein 4 homolog C)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; protein delipidation [GO:0051697]; protein processing [GO:0016485]	cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; protein-phosphatidylethanolamide deconjugating activity [GO:0019786]	cytoplasm [GO:0005737]	GO:0000045; GO:0000423; GO:0004197; GO:0005737; GO:0006914; GO:0008234; GO:0016485; GO:0019786; GO:0034727; GO:0035973; GO:0051697
GN011285	GN011285.1	A0A1L8G016	50.6	484	469	469	3.03e-111	339	DAA11_XENLA	Dynein axonemal assembly factor 11 (DNAAF11) (Leucine-rich repeat-containing protein 6) (Protein tilB homolog)	Xenopus laevis (African clawed frog)	axonemal dynein complex assembly [GO:0070286]; cerebrospinal fluid circulation [GO:0090660]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; outer dynein arm assembly [GO:0036158]; protein localization to cilium [GO:0061512]; protein localization to motile cilium [GO:0120229]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; motile cilium [GO:0031514]	GO:0003351; GO:0005576; GO:0005737; GO:0005829; GO:0030317; GO:0031514; GO:0036158; GO:0060287; GO:0061512; GO:0070286; GO:0090660; GO:0120229; GO:0120293
GN011286	GN011286.1	Q6NYM1	29.5	562	570	613	4.64e-73	248	KLH21_DANRE	Kelch-like protein 21	Danio rerio (Zebrafish) (Brachydanio rerio)	chromosome passenger complex localization to spindle midzone [GO:0035853]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; polar microtubule [GO:0005827]	GO:0005737; GO:0005827; GO:0016567; GO:0031463; GO:0032465; GO:0035853; GO:0043161; GO:1990756
GN011287	GN011287.1	A4D2P6	29.5	1030	1235	1211	2.21e-78	286	GRD2I_HUMAN	Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)	Homo sapiens (Human)	regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]		cerebellar granule cell to Purkinje cell synapse [GO:0150048]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic density, intracellular component [GO:0099092]; postsynaptic membrane [GO:0045211]	GO:0045211; GO:0098688; GO:0099072; GO:0099092; GO:0099566; GO:0150048
GN011289	GN011289.1	B2GV50	60.2	591	761	692	3.43e-221	639	RFX2_RAT	DNA-binding protein RFX2 (Regulatory factor X 2)	Rattus norvegicus (Rat)	acrosome assembly [GO:0001675]; cellular response to leukemia inhibitory factor [GO:1990830]; cilium assembly [GO:0060271]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0001675; GO:0003700; GO:0005634; GO:0005737; GO:0006357; GO:0007286; GO:0045944; GO:0060271; GO:1990830; GO:1990837
GN011290	GN011290.1	Q7T312	60.3	68	100	207	6.54e-21	85.5	CCD25_DANRE	Coiled-coil domain-containing protein 25	Danio rerio (Zebrafish) (Brachydanio rerio)	positive regulation of cell motility [GO:2000147]	DNA binding [GO:0003677]	endomembrane system [GO:0012505]; plasma membrane [GO:0005886]	GO:0003677; GO:0005886; GO:0012505; GO:2000147
GN011292	GN011292.1	Q2T9W9	28.1	235	268	362	2.55e-10	63.5	CAAP1_BOVIN	Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP)	Bos taurus (Bovine)	negative regulation of apoptotic process [GO:0043066]			GO:0043066
GN011294	GN011294.1	Q91XQ5	34.7	320	450	561	4.90e-54	192	CHSTF_MOUSE	Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST)	Mus musculus (Mouse)	hexose biosynthetic process [GO:0019319]	3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity [GO:0050659]	Golgi membrane [GO:0000139]	GO:0000139; GO:0019319; GO:0050656; GO:0050659
GN011296	GN011296.1	Q7SZT7	58.3	374	392	400	9.13e-137	399	ELAV4_XENLA	ELAV-like protein 4 (Protein ElrD)	Xenopus laevis (African clawed frog)	3'-UTR-mediated mRNA stabilization [GO:0070935]; intracellular mRNA localization [GO:0008298]	protein-RNA adaptor activity [GO:0140517]; RNA binding [GO:0003723]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; perikaryon [GO:0043204]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005737; GO:0005938; GO:0008298; GO:0030425; GO:0030426; GO:0043204; GO:0070935; GO:0140517; GO:1990904
GN011302	GN011302.1	Q8NC51	46.3	162	375	408	2.34e-20	95.1	SERB1_HUMAN	SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein)	Homo sapiens (Human)	negative regulation of translation [GO:0017148]; PML body organization [GO:0030578]; regulation of mRNA stability [GO:0043488]; ribosome hibernation [GO:0141014]	cadherin binding [GO:0045296]; mRNA 3'-UTR binding [GO:0003730]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SUMO binding [GO:0032183]; translation elongation factor binding [GO:0061770]; translation repressor activity [GO:0030371]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0003723; GO:0003730; GO:0005634; GO:0005737; GO:0005829; GO:0016020; GO:0017148; GO:0030371; GO:0030578; GO:0032183; GO:0043022; GO:0043488; GO:0045296; GO:0048471; GO:0061770; GO:0070062; GO:0141014
GN011303	GN011303.1	Q5U2Z0	60.8	166	367	340	3.64e-32	126	ZN367_RAT	Zinc finger protein 367	Rattus norvegicus (Rat)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0003700; GO:0005634; GO:0005654; GO:0006357
GN011304	GN011304.1	Q90511	65.8	243	242	355	3.56e-108	318	EI2BB_TAKRU	Translation initiation factor eIF2B subunit beta (S20I15) (eIF2B GDP-GTP exchange factor subunit beta)	Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)	animal organ development [GO:0048513]; central nervous system development [GO:0007417]; cytoplasmic translational initiation [GO:0002183]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]	GO:0002183; GO:0003743; GO:0005085; GO:0005524; GO:0005525; GO:0005737; GO:0005829; GO:0005851; GO:0006413; GO:0007417; GO:0014003; GO:0042552; GO:0048513; GO:0050852
GN011305	GN011305.1	Q90511	53.5	99	107	355	1.89e-23	95.1	EI2BB_TAKRU	Translation initiation factor eIF2B subunit beta (S20I15) (eIF2B GDP-GTP exchange factor subunit beta)	Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)	animal organ development [GO:0048513]; central nervous system development [GO:0007417]; cytoplasmic translational initiation [GO:0002183]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; T cell receptor signaling pathway [GO:0050852]; translational initiation [GO:0006413]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]	GO:0002183; GO:0003743; GO:0005085; GO:0005524; GO:0005525; GO:0005737; GO:0005829; GO:0005851; GO:0006413; GO:0007417; GO:0014003; GO:0042552; GO:0048513; GO:0050852
GN011306	GN011306.1	Q8TEK3	46.3	553	1643	1537	4.68e-119	415	DOT1L_HUMAN	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Disruptor of telomeric silencing 1-like histone lysine methyltransferase) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)	Homo sapiens (Human)	DNA damage checkpoint signaling [GO:0000077]; DNA repair [GO:0006281]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of receptor signaling pathway via JAK-STAT [GO:0046425]; regulation of transcription regulatory region DNA binding [GO:2000677]; subtelomeric heterochromatin formation [GO:0031509]; telomere organization [GO:0032200]	DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K79 methyltransferase activity [GO:0031151]; histone H3K79 trimethyltransferase activity [GO:0140956]; histone methyltransferase activity [GO:0042054]; nucleic acid binding [GO:0003676]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000077; GO:0000781; GO:0003676; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0031151; GO:0031509; GO:0032200; GO:0032991; GO:0042054; GO:0045944; GO:0046425; GO:0061629; GO:0140938; GO:0140956; GO:2000677
GN011308	GN011308.1	O95816	38.2	165	178	211	2.46e-24	97.4	BAG2_HUMAN	BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2)	Homo sapiens (Human)	negative regulation of protein ubiquitination [GO:0031397]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein processing [GO:0010954]; protein folding [GO:0006457]; protein metabolic process [GO:0019538]; protein stabilization [GO:0050821]	adenyl-nucleotide exchange factor activity [GO:0000774]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; protein-folding chaperone binding [GO:0051087]; tau protein binding [GO:0048156]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic microtubule [GO:1901588]; protein folding chaperone complex [GO:0101031]	GO:0000774; GO:0005829; GO:0006457; GO:0010954; GO:0019538; GO:0030424; GO:0030425; GO:0031072; GO:0031397; GO:0031625; GO:0042802; GO:0044325; GO:0048156; GO:0050821; GO:0051087; GO:0101031; GO:1901588; GO:1901800
GN011310	GN011310.1	P35288	61.4	241	255	237	3.03e-95	282	RAB23_MOUSE	Ras-related protein Rab-23 (EC 3.6.5.2) (Protein open brain) (Rab-15)	Mus musculus (Mouse)	autophagosome assembly [GO:0000045]; cellular defense response [GO:0006968]; cilium assembly [GO:0060271]; craniofacial suture morphogenesis [GO:0097094]; dorsal/ventral neural tube patterning [GO:0021904]; embryonic digit morphogenesis [GO:0042733]; GTP metabolic process [GO:0046039]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of proteolysis [GO:0045861]; negative regulation of smoothened signaling pathway [GO:0045879]; nervous system development [GO:0007399]; neural tube closure [GO:0001843]; regulation of protein localization [GO:0032880]; regulation of smoothened signaling pathway [GO:0008589]; signal transduction [GO:0007165]; spinal cord dorsal/ventral patterning [GO:0021513]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	autophagosome [GO:0005776]; cell junction [GO:0030054]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	GO:0000045; GO:0001843; GO:0003924; GO:0003925; GO:0005525; GO:0005737; GO:0005776; GO:0005813; GO:0005829; GO:0005886; GO:0005929; GO:0006968; GO:0007165; GO:0007399; GO:0008589; GO:0010008; GO:0021513; GO:0021904; GO:0030054; GO:0030670; GO:0032880; GO:0036064; GO:0042308; GO:0042733; GO:0045335; GO:0045861; GO:0045879; GO:0046039; GO:0060271; GO:0097094
GN011311	GN011311.1	Q0IIF7	62.3	494	486	494	1.18e-223	627	UBP14_BOVIN	Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)	Bos taurus (Bovine)	negative regulation of ERAD pathway [GO:1904293]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]; proteasome binding [GO:0070628]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004843; GO:0005737; GO:0005886; GO:0016579; GO:0043161; GO:0070628; GO:1904293
GN011314	GN011314.1	Q9Y5X5	28.8	260	394	522	6.14e-29	121	NPFF2_HUMAN	Neuropeptide FF receptor 2 (G protein-coupled receptor 74) (G protein-coupled receptor HLWAR77) (Neuropeptide G protein-coupled receptor)	Homo sapiens (Human)	cellular response to hormone stimulus [GO:0032870]; detection of abiotic stimulus [GO:0009582]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; regulation of MAPK cascade [GO:0043408]	G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007186; GO:0007218; GO:0008188; GO:0009582; GO:0031628; GO:0032870; GO:0043408
GN011316	GN011316.1	Q90ZY4	52.2	278	356	385	5.32e-102	308	SBK1_DANRE	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (Brain-specific protein kinase BSK146) (SH3 domain-binding kinase 1)	Danio rerio (Zebrafish) (Brachydanio rerio)		ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]	GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0106310
GN011319	GN011319.1	Q6AYB3	58.0	143	178	284	1.91e-47	159	ISY1_RAT	Pre-mRNA-splicing factor ISY1 homolog	Rattus norvegicus (Rat)	generation of catalytic spliceosome for second transesterification step [GO:0000350]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]		catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0000350; GO:0000389; GO:0000398; GO:0000974; GO:0005634; GO:0016607; GO:0071006; GO:0071013; GO:0071014; GO:0071020
GN011321	GN011321.1	Q8QGW7	41.0	105	159	148	2.38e-17	77.0	LITAF_CHICK	Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome)	Gallus gallus (Chicken)	cytokine production [GO:0001816]; regulation of cytokine production [GO:0001817]; sexual reproduction [GO:0019953]	cytokine activity [GO:0005125]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytoplasmic side of plasma membrane [GO:0009898]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000139; GO:0001816; GO:0001817; GO:0005125; GO:0005634; GO:0005737; GO:0005765; GO:0005886; GO:0008270; GO:0009898; GO:0010008; GO:0019953; GO:0031901; GO:0031902; GO:0098559; GO:0098560; GO:0098574
GN011322	GN011322.1	O88582	39.4	170	268	198	3.43e-30	115	SOCS2_RAT	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2)	Rattus norvegicus (Rat)	cellular response to hormone stimulus [GO:0032870]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway [GO:0060396]; intracellular signal transduction [GO:0035556]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; positive regulation of neuron differentiation [GO:0045666]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of multicellular organism growth [GO:0040014]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]	cytokine receptor binding [GO:0005126]; growth hormone receptor binding [GO:0005131]; insulin-like growth factor receptor binding [GO:0005159]; phosphorylation-dependent protein binding [GO:0140031]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]	GO:0005126; GO:0005131; GO:0005159; GO:0005737; GO:0007595; GO:0009968; GO:0016567; GO:0019221; GO:0031466; GO:0032355; GO:0032870; GO:0035556; GO:0040014; GO:0040015; GO:0043161; GO:0043434; GO:0045666; GO:0046426; GO:0060396; GO:0060400; GO:0060749; GO:0140031; GO:1990756
GN011323	GN011323.1	P04183	60.0	190	201	234	8.05e-71	218	KITH_HUMAN	Thymidine kinase, cytosolic (EC 2.7.1.21)	Homo sapiens (Human)	DNA synthesis involved in mitotic DNA replication [GO:1904860]; dTMP salvage [GO:0036198]; nucleobase-containing compound metabolic process [GO:0006139]; protein homotetramerization [GO:0051289]; thymidine biosynthetic process [GO:0046105]; thymidine metabolic process [GO:0046104]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; thymidine kinase activity [GO:0004797]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004797; GO:0005524; GO:0005634; GO:0005829; GO:0006139; GO:0008270; GO:0036198; GO:0042802; GO:0046104; GO:0046105; GO:0051289; GO:1904860
GN011324	GN011324.1	Q9CR92	48.2	326	605	584	2.41e-78	262	CF184_MOUSE	Cilia- and flagella-associated protein 184	Mus musculus (Mouse)	cilium assembly [GO:0060271]		axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]	GO:0005813; GO:0005930; GO:0036064; GO:0060271
GN011325	GN011325.1	Q3UG98	54.3	199	197	241	6.11e-66	205	NAT9_MOUSE	Alpha/beta-tubulin-N-acetyltransferase 9 (EC 2.3.1.308)	Mus musculus (Mouse)	regulation of mitotic spindle assembly [GO:1901673]	tubulin N-terminal-methionine acetyltransferase activity [GO:0120519]	protein-containing complex [GO:0032991]	GO:0032991; GO:0120519; GO:1901673
GN011326	GN011326.1	Q02962	67.8	214	602	417	3.01e-79	259	PAX2_HUMAN	Paired box protein Pax-2	Homo sapiens (Human)	axonogenesis [GO:0007409]; brain morphogenesis [GO:0048854]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye development [GO:0043010]; cell fate determination [GO:0001709]; cellular response to glucose stimulus [GO:0071333]; cellular response to retinoic acid [GO:0071300]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; glial cell differentiation [GO:0010001]; inner ear morphogenesis [GO:0042472]; mesenchymal to epithelial transition [GO:0060231]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesodermal cell fate specification [GO:0007501]; mesonephros development [GO:0001823]; metanephric collecting duct development [GO:0072205]; metanephric distal convoluted tubule development [GO:0072221]; metanephric epithelium development [GO:0072207]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchyme development [GO:0072075]; metanephric nephron tubule formation [GO:0072289]; metanephros development [GO:0001656]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; nephric duct formation [GO:0072179]; nervous system development [GO:0007399]; neural tube closure [GO:0001843]; optic chiasma development [GO:0061360]; optic cup morphogenesis involved in camera-type eye development [GO:0002072]; optic nerve development [GO:0021554]; optic nerve morphogenesis [GO:0021631]; optic nerve structural organization [GO:0021633]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of metanephric DCT cell differentiation [GO:2000594]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of optic nerve formation [GO:2000597]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephric field specification [GO:0039003]; pronephros development [GO:0048793]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of metanephros size [GO:0035566]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal pigment epithelium development [GO:0003406]; sensory organ development [GO:0007423]; stem cell differentiation [GO:0048863]; ureter development [GO:0072189]; ureter maturation [GO:0035799]; urogenital system development [GO:0001655]; vestibulocochlear nerve formation [GO:0021650]; visual perception [GO:0007601]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription factor binding [GO:0008134]	centriolar satellite [GO:0034451]; chromatin [GO:0000785]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]	GO:0000785; GO:0000976; GO:0000978; GO:0000981; GO:0000987; GO:0001655; GO:0001656; GO:0001658; GO:0001709; GO:0001823; GO:0001843; GO:0002072; GO:0003337; GO:0003406; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005815; GO:0006357; GO:0007399; GO:0007409; GO:0007423; GO:0007501; GO:0007601; GO:0008134; GO:0010001; GO:0021554; GO:0021631; GO:0021633; GO:0021650; GO:0032991; GO:0032993; GO:0034451; GO:0035566; GO:0035799; GO:0039003; GO:0042472; GO:0043010; GO:0043066; GO:0043069; GO:0045892; GO:0045893; GO:0045944; GO:0048793; GO:0048854; GO:0048863; GO:0050679; GO:0060231; GO:0061360; GO:0071300; GO:0071333; GO:0072075; GO:0072108; GO:0072162; GO:0072179; GO:0072189; GO:0072205; GO:0072207; GO:0072221; GO:0072289; GO:0072300; GO:0072307; GO:0090102; GO:0090103; GO:1990837; GO:2000378; GO:2000594; GO:2000597
GN011327	GN011327.1	Q8QGW7	42.3	111	122	148	1.04e-23	92.0	LITAF_CHICK	Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome)	Gallus gallus (Chicken)	cytokine production [GO:0001816]; regulation of cytokine production [GO:0001817]; sexual reproduction [GO:0019953]	cytokine activity [GO:0005125]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of late endosome membrane [GO:0098560]; cytoplasmic side of lysosomal membrane [GO:0098574]; cytoplasmic side of plasma membrane [GO:0009898]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000139; GO:0001816; GO:0001817; GO:0005125; GO:0005634; GO:0005737; GO:0005765; GO:0005886; GO:0008270; GO:0009898; GO:0010008; GO:0019953; GO:0031901; GO:0031902; GO:0098559; GO:0098560; GO:0098574
GN011328	GN011328.1	P27080	45.6	287	331	308	2.30e-83	257	ADT_CHLRE	ADP/ATP translocase (ADP,ATP carrier protein) (Adenine nucleotide translocator) (ANT)	Chlamydomonas reinhardtii (Chlamydomonas smithii)	mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]	ATP:ADP antiporter activity [GO:0005471]	mitochondrial inner membrane [GO:0005743]	GO:0005471; GO:0005743; GO:0140021; GO:1990544
GN011334	GN011334.1	O74378	47.2	53	60	1009	4.30e-10	56.2	ODO1_SCHPO	2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	tricarboxylic acid cycle [GO:0006099]	oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976]	mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252]	GO:0004591; GO:0005739; GO:0006099; GO:0030976; GO:0042645; GO:0045252
GN011336	GN011336.1	Q6AZB8	33.0	176	196	349	8.67e-21	91.3	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN011338	GN011338.1	P12276	37.1	2531	2482	2512	0.0	1541	FAS_CHICK	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]	Gallus gallus (Chicken)	fatty acid biosynthetic process [GO:0006633]; lactate metabolic process [GO:0006089]; positive regulation of appetite [GO:0032100]	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [GO:0019171]; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; [acyl-carrier-protein] S-acetyltransferase activity [GO:0004313]; [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; enoyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0141148]; fatty acid synthase activity [GO:0004312]; fatty acyl-[ACP] hydrolase activity [GO:0016297]; phosphopantetheine binding [GO:0031177]; single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]	GO:0003697; GO:0004312; GO:0004313; GO:0004314; GO:0004315; GO:0004316; GO:0005737; GO:0006089; GO:0006633; GO:0016297; GO:0019171; GO:0031177; GO:0032100; GO:0141148
GN011339	GN011339.1	Q9EP80	74.2	376	430	416	4.31e-202	567	PICK1_RAT	PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein)	Rattus norvegicus (Rat)	AMPA glutamate receptor clustering [GO:0097113]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to glucose starvation [GO:0042149]; cellular response to glycine [GO:1905430]; dendritic spine maintenance [GO:0097062]; dendritic spine organization [GO:0097061]; glial cell development [GO:0021782]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of gene expression [GO:0010629]; positive regulation of AMPA glutamate receptor clustering [GO:1904719]; positive regulation of receptor internalization [GO:0002092]; protein insertion into plasma membrane [GO:0098737]; protein phosphorylation [GO:0006468]; protein targeting [GO:0006605]; receptor clustering [GO:0043113]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; regulation of insulin secretion [GO:0050796]; regulation of kainate selective glutamate receptor signaling pathway [GO:0106426]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; response to phorbol 13-acetate 12-myristate [GO:1904627]	actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; cytoskeletal protein binding [GO:0008092]; ephrin receptor binding [GO:0046875]; G protein-coupled glutamate receptor binding [GO:0035256]; G protein-coupled receptor binding [GO:0001664]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; membrane curvature sensor activity [GO:0140090]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; signaling receptor complex adaptor activity [GO:0030159]; SNAP receptor activity [GO:0005484]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; dendritic spine cytoplasm [GO:0061846]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic endocytic zone [GO:0098843]; postsynaptic specialization [GO:0099572]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]	GO:0001664; GO:0002092; GO:0005080; GO:0005102; GO:0005484; GO:0005543; GO:0005737; GO:0005739; GO:0005794; GO:0005829; GO:0005856; GO:0005886; GO:0006468; GO:0006605; GO:0006886; GO:0008021; GO:0008092; GO:0010629; GO:0014069; GO:0016020; GO:0019904; GO:0021782; GO:0030159; GO:0030425; GO:0030971; GO:0032588; GO:0032991; GO:0034315; GO:0034316; GO:0035255; GO:0035256; GO:0036294; GO:0042149; GO:0042734; GO:0042802; GO:0043005; GO:0043113; GO:0043197; GO:0045202; GO:0046875; GO:0048471; GO:0050796; GO:0051015; GO:0051020; GO:0060076; GO:0060292; GO:0061846; GO:0071933; GO:0097061; GO:0097062; GO:0097113; GO:0098737; GO:0098831; GO:0098843; GO:0098978; GO:0099149; GO:0099572; GO:0106426; GO:0140090; GO:1904627; GO:1904719; GO:1905430
GN011340	GN011340.1	Q28DT9	40.3	211	222	360	1.58e-41	147	SPSB3_XENTR	SPRY domain-containing SOCS box protein 3 (SSB-3)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; nucleus [GO:0005634]	GO:0005634; GO:0010719; GO:0031466; GO:0043161; GO:0070936; GO:0160049; GO:1990756
GN011342	GN011342.1	O70201	50.4	127	140	140	3.34e-43	142	BIRC5_MOUSE	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) (TIAP)	Mus musculus (Mouse)	cell division [GO:0051301]; chromosome localization [GO:0050000]; G2/M transition of mitotic cell cycle [GO:0000086]; meiosis I [GO:0007127]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of cell cycle [GO:0045787]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; protein-containing complex localization [GO:0031503]; regulation of cell cycle [GO:0051726]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of mitotic cell cycle [GO:0007346]; regulation of type B pancreatic cell proliferation [GO:0061469]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; small GTPase binding [GO:0031267]; tubulin binding [GO:0015631]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; centriole [GO:0005814]; chromosome [GO:0005694]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; interphase microtubule organizing center [GO:0031021]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear chromosome [GO:0000228]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spindle microtubule [GO:0005876]; survivin complex [GO:1990713]	GO:0000086; GO:0000226; GO:0000228; GO:0000278; GO:0000281; GO:0000775; GO:0000776; GO:0001934; GO:0005634; GO:0005694; GO:0005737; GO:0005814; GO:0005829; GO:0005876; GO:0005881; GO:0007052; GO:0007094; GO:0007127; GO:0007346; GO:0008017; GO:0008270; GO:0015630; GO:0015631; GO:0016324; GO:0019899; GO:0030496; GO:0031021; GO:0031267; GO:0031398; GO:0031503; GO:0031536; GO:0032133; GO:0032991; GO:0042802; GO:0042803; GO:0043027; GO:0043066; GO:0043524; GO:0045171; GO:0045787; GO:0045892; GO:0045931; GO:0046982; GO:0050000; GO:0051087; GO:0051256; GO:0051301; GO:0051726; GO:0061178; GO:0061469; GO:0061630; GO:0090267; GO:1901970; GO:1902425; GO:1903490; GO:1990713
GN011343	GN011343.1	Q6PHN1	31.7	839	1072	1016	5.52e-54	208	CCD57_MOUSE	Coiled-coil domain-containing protein 57	Mus musculus (Mouse)	axoneme assembly [GO:0035082]; centriole replication [GO:0007099]; cerebrospinal fluid circulation [GO:0090660]; ciliary basal body organization [GO:0032053]; cilium assembly [GO:0060271]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; establishment of epithelial cell polarity [GO:0090162]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule nucleation [GO:0007020]; positive regulation of mitotic cell cycle [GO:0045931]		centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; extracellular region [GO:0005576]; spindle microtubule [GO:0005876]	GO:0000086; GO:0003351; GO:0005576; GO:0005813; GO:0005814; GO:0005876; GO:0007020; GO:0007099; GO:0032053; GO:0034451; GO:0035082; GO:0036064; GO:0045931; GO:0060271; GO:0090162; GO:0090660
GN011345	GN011345.1	Q9UBC3	35.1	643	897	853	1.62e-113	370	DNM3B_HUMAN	DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]	DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [GO:0051718]; DNA binding [GO:0003677]; DNA-methyltransferase activity [GO:0009008]; transcription corepressor activity [GO:0003714]	catalytic complex [GO:1902494]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0003677; GO:0003714; GO:0003886; GO:0005634; GO:0005654; GO:0009008; GO:0010628; GO:0051718; GO:1902494
GN011346	GN011346.1	Q6DIV6	45.1	397	421	518	1.17e-115	350	VIAAT_XENTR	Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	amino acid transmembrane transport [GO:0003333]; beta-alanine transport [GO:0001762]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid transport [GO:0015812]; glycine transport [GO:0015816]	gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:proton antiporter activity [GO:0140800]; glycine transmembrane transporter activity [GO:0015187]; glycine:proton antiporter activity [GO:0140799]; L-amino acid transmembrane transporter activity [GO:0015179]	cytoplasmic vesicle membrane [GO:0030659]; inhibitory synapse [GO:0060077]; presynapse [GO:0098793]; synaptic vesicle [GO:0008021]	GO:0001762; GO:0003333; GO:0008021; GO:0015179; GO:0015185; GO:0015187; GO:0015812; GO:0015816; GO:0030659; GO:0051939; GO:0060077; GO:0098793; GO:0140799; GO:0140800
GN011348	GN011348.1	Q9N293	36.8	253	311	298	2.78e-49	169	B3GT5_GORGO	Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)	Gorilla gorilla gorilla (Western lowland gorilla)	glycoprotein biosynthetic process [GO:0009101]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0008499; GO:0009101
GN011349	GN011349.1	Q60437	31.6	187	443	521	4.04e-12	71.6	BAIP2_CRIGR	BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate) (p58/p53)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; neuron differentiation [GO:0030182]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]	cytoskeletal adaptor activity [GO:0008093]; proline-rich region binding [GO:0070064]	cytosol [GO:0005829]; filopodium [GO:0030175]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GO:0001726; GO:0005654; GO:0005829; GO:0005886; GO:0007009; GO:0008093; GO:0008360; GO:0030175; GO:0030182; GO:0030838; GO:0032956; GO:0051017; GO:0051764; GO:0070064
GN011350	GN011350.1	Q6GMN2	34.2	114	144	535	4.98e-10	59.7	BAIP2_RAT	BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53)	Rattus norvegicus (Rat)	actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to L-glutamate [GO:1905232]; dendrite development [GO:0016358]; filopodium assembly [GO:0046847]; modulation of chemical synaptic transmission [GO:0050804]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuron projection morphogenesis [GO:0048812]; plasma membrane organization [GO:0007009]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron projection development [GO:0010976]; protein localization to synapse [GO:0035418]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic plasticity [GO:0048167]; wound healing [GO:0042060]	cytoskeletal adaptor activity [GO:0008093]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; proline-rich region binding [GO:0070064]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; scaffold protein binding [GO:0097110]; transcription coregulator binding [GO:0001221]	actin cytoskeleton [GO:0015629]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; dendritic spine cytoplasm [GO:0061846]; excitatory synapse [GO:0060076]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuron projection branch point [GO:0061845]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; presynapse [GO:0098793]; presynaptic cytosol [GO:0099523]; ruffle [GO:0001726]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; synaptic membrane [GO:0097060]	GO:0001221; GO:0001726; GO:0001764; GO:0005829; GO:0005874; GO:0005886; GO:0007009; GO:0008093; GO:0008360; GO:0009898; GO:0010976; GO:0014069; GO:0015629; GO:0016358; GO:0030027; GO:0030141; GO:0030165; GO:0030175; GO:0030182; GO:0030674; GO:0030838; GO:0032956; GO:0035418; GO:0042060; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0043197; GO:0043198; GO:0044306; GO:0046847; GO:0048167; GO:0048812; GO:0050804; GO:0051017; GO:0051764; GO:0060076; GO:0061003; GO:0061845; GO:0061846; GO:0070064; GO:0071364; GO:0097060; GO:0097110; GO:0098685; GO:0098793; GO:0098794; GO:0098978; GO:0099092; GO:0099175; GO:0099523; GO:0099524; GO:1905232; GO:1905274; GO:2000463
GN011351	GN011351.1	O75340	42.1	195	320	191	3.45e-43	150	PDCD6_HUMAN	Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2)	Homo sapiens (Human)	apoptotic signaling pathway [GO:0097190]; cellular response to heat [GO:0034605]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]	calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]; protein-membrane adaptor activity [GO:0043495]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	COPII vesicle coat [GO:0030127]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0000287; GO:0001938; GO:0005509; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005783; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0010595; GO:0014029; GO:0014032; GO:0030127; GO:0030674; GO:0030948; GO:0031410; GO:0031463; GO:0032007; GO:0034605; GO:0036324; GO:0042802; GO:0042803; GO:0043065; GO:0043495; GO:0045766; GO:0046982; GO:0046983; GO:0048208; GO:0048306; GO:0048471; GO:0051592; GO:0051898; GO:0070062; GO:0070971; GO:0097190; GO:1902527; GO:1990756
GN011353	GN011353.1	O35625	32.6	960	909	863	1.57e-83	290	AXIN1_MOUSE	Axin-1 (Axis inhibition protein 1) (Protein Fused)	Mus musculus (Mouse)	axial mesoderm development [GO:0048318]; axial mesoderm formation [GO:0048320]; beta-catenin destruction complex assembly [GO:1904885]; canonical Wnt signaling pathway [GO:0060070]; cell development [GO:0048468]; cellular response to glucose starvation [GO:0042149]; cytoplasmic microtubule organization [GO:0031122]; dorsal/ventral axis specification [GO:0009950]; dorsal/ventral pattern formation [GO:0009953]; epigenetic programming in the zygotic pronuclei [GO:0044725]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; negative regulation of Wnt signaling pathway [GO:0030178]; nucleocytoplasmic transport [GO:0006913]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; post-anal tail morphogenesis [GO:0036342]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; protein-containing complex assembly [GO:0065003]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of protein phosphorylation [GO:0001932]; sensory perception of sound [GO:0007605]; Wnt signaling pathway [GO:0016055]	armadillo repeat domain binding [GO:0070016]; beta-catenin binding [GO:0008013]; enzyme binding [GO:0019899]; I-SMAD binding [GO:0070411]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; p53 binding [GO:0002039]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase binding [GO:0120283]; protein-macromolecule adaptor activity [GO:0030674]; R-SMAD binding [GO:0070412]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; SMAD binding [GO:0046332]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	beta-catenin destruction complex [GO:0030877]; cell cortex [GO:0005938]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; Wnt signalosome [GO:1990909]	GO:0000209; GO:0001701; GO:0001932; GO:0001934; GO:0002039; GO:0005102; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005770; GO:0005794; GO:0005829; GO:0005886; GO:0005938; GO:0006913; GO:0007605; GO:0008013; GO:0009950; GO:0009953; GO:0010629; GO:0015630; GO:0016020; GO:0016055; GO:0016328; GO:0019899; GO:0019901; GO:0019904; GO:0030163; GO:0030178; GO:0030511; GO:0030674; GO:0030877; GO:0031122; GO:0031398; GO:0031410; GO:0031625; GO:0032436; GO:0032991; GO:0034244; GO:0035591; GO:0036342; GO:0042149; GO:0042802; GO:0042803; GO:0043161; GO:0043507; GO:0043539; GO:0044725; GO:0045202; GO:0045599; GO:0045732; GO:0045860; GO:0046330; GO:0046332; GO:0048318; GO:0048320; GO:0048468; GO:0048471; GO:0051248; GO:0060070; GO:0060090; GO:0060322; GO:0060828; GO:0065003; GO:0070016; GO:0070411; GO:0070412; GO:0071944; GO:0090090; GO:0120283; GO:1904885; GO:1990756; GO:1990909; GO:2000060
GN011354	GN011354.1	Q0IHH9	33.1	181	349	374	1.84e-15	80.1	SPOPB_XENLA	Speckle-type POZ protein B	Xenopus laevis (African clawed frog)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of proteolysis [GO:0030162]	ubiquitin protein ligase binding [GO:0031625]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0016567; GO:0016607; GO:0030162; GO:0031463; GO:0031625; GO:0043161
GN011363	GN011363.1	P23953	32.1	542	584	554	1.87e-71	242	EST1C_MOUSE	Carboxylesterase 1C (EC 3.1.1.1) (Liver carboxylesterase N) (Lung surfactant convertase) (PES-N)	Mus musculus (Mouse)	response to bacterium [GO:0009617]; short-chain fatty acid catabolic process [GO:0019626]	carboxylesterase activity [GO:0106435]; hydrolase activity, acting on ester bonds [GO:0016788]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; protein homodimerization activity [GO:0042803]; retinyl-palmitate esterase activity [GO:0050253]; sterol ester esterase activity [GO:0004771]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]	GO:0004771; GO:0005576; GO:0005737; GO:0005783; GO:0005788; GO:0005811; GO:0009617; GO:0016788; GO:0019626; GO:0042803; GO:0047374; GO:0050253; GO:0106435
GN011364	GN011364.1	Q92035	32.4	500	491	606	2.68e-64	222	ACES_BUNFA	Acetylcholinesterase (BfAChE) (EC 3.1.1.7)	Bungarus fasciatus (Banded krait) (Pseudoboa fasciata)	acetylcholine catabolic process in synaptic cleft [GO:0001507]; choline metabolic process [GO:0019695]	acetylcholinesterase activity [GO:0003990]	plasma membrane [GO:0005886]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001507; GO:0003990; GO:0005886; GO:0019695; GO:0043083; GO:0045202
GN011365	GN011365.1	P16303	34.0	556	579	565	2.53e-75	253	EST1D_RAT	Carboxylesterase 1D (Carboxyesterase ES-10) (Carboxylesterase 3) (EC 3.1.1.1, EC 3.1.1.67) (ES-HVEL) (Fatty acid ethyl ester synthase) (FAEE synthase) (Liver carboxylesterase 10) (pI 6.1 esterase)	Rattus norvegicus (Rat)	acylglycerol catabolic process [GO:0046464]; cellular response to cholesterol [GO:0071397]; cellular response to cold [GO:0070417]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol biosynthetic process [GO:0006695]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; circadian temperature homeostasis [GO:0060086]; cold-induced thermogenesis [GO:0106106]; cytosolic lipolysis [GO:0061725]; epithelial cell differentiation [GO:0030855]; lipid catabolic process [GO:0016042]; medium-chain fatty acid metabolic process [GO:0051791]; negative regulation of cholesterol storage [GO:0010887]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of bile acid secretion [GO:0120188]; response to ethanol [GO:0045471]; retinoid metabolic process [GO:0001523]; reverse cholesterol transport [GO:0043691]; short-chain fatty acid catabolic process [GO:0019626]; very-low-density lipoprotein particle assembly [GO:0034379]	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; fatty-acyl-ethyl-ester synthase activity [GO:0030339]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; retinyl-palmitate esterase activity [GO:0050253]; sterol ester esterase activity [GO:0004771]; triacylglycerol lipase activity [GO:0004806]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]	GO:0001523; GO:0004771; GO:0004806; GO:0005737; GO:0005783; GO:0005788; GO:0005811; GO:0005829; GO:0006695; GO:0008203; GO:0010875; GO:0010887; GO:0016042; GO:0019626; GO:0030339; GO:0030855; GO:0034379; GO:0042632; GO:0043231; GO:0043691; GO:0045471; GO:0045944; GO:0046464; GO:0047374; GO:0047376; GO:0050253; GO:0051791; GO:0052689; GO:0060086; GO:0061725; GO:0070417; GO:0070857; GO:0071397; GO:0071404; GO:0090205; GO:0106106; GO:0106435; GO:0120188
GN011366	GN011366.1	Q92035	32.6	564	580	606	3.65e-73	248	ACES_BUNFA	Acetylcholinesterase (BfAChE) (EC 3.1.1.7)	Bungarus fasciatus (Banded krait) (Pseudoboa fasciata)	acetylcholine catabolic process in synaptic cleft [GO:0001507]; choline metabolic process [GO:0019695]	acetylcholinesterase activity [GO:0003990]	plasma membrane [GO:0005886]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001507; GO:0003990; GO:0005886; GO:0019695; GO:0043083; GO:0045202
GN011368	GN011368.1	Q18PE1	38.1	202	1634	504	6.27e-36	147	DOK7_HUMAN	Protein Dok-7 (Downstream of tyrosine kinase 7)	Homo sapiens (Human)	enzyme-linked receptor protein signaling pathway [GO:0007167]; neuromuscular junction development [GO:0007528]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of Rac protein signal transduction [GO:0035022]	phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]; signaling adaptor activity [GO:0035591]	mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; postsynaptic membrane [GO:0045211]	GO:0005654; GO:0005739; GO:0007167; GO:0007528; GO:0019901; GO:0031594; GO:0035022; GO:0035091; GO:0035591; GO:0045211; GO:0061098
GN011370	GN011370.1	Q91821	46.7	692	673	651	1.85e-200	582	MELK_XENLA	Maternal embryonic leucine zipper kinase (MELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase)	Xenopus laevis (African clawed frog)	apoptotic process [GO:0006915]; cell population proliferation [GO:0008283]; hemopoiesis [GO:0030097]; intracellular signal transduction [GO:0035556]; neural precursor cell proliferation [GO:0061351]; positive regulation of apoptotic process [GO:0043065]; protein autophosphorylation [GO:0046777]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004674; GO:0004715; GO:0005509; GO:0005524; GO:0005737; GO:0005886; GO:0005938; GO:0006915; GO:0008283; GO:0030097; GO:0035556; GO:0043065; GO:0046777; GO:0061351; GO:0106310
GN011377	GN011377.1	Q24180	43.8	80	166	576	1.07e-14	73.9	DEAF1_DROME	Deformed epidermal autoregulatory factor 1 (Protein DEAF-1)	Drosophila melanogaster (Fruit fly)	embryo development ending in birth or egg hatching [GO:0009792]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of immune response [GO:0050776]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]	GO:0000981; GO:0003700; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0043565; GO:0045893; GO:0050776
GN011379	GN011379.1	P16303	33.6	581	581	565	4.04e-80	265	EST1D_RAT	Carboxylesterase 1D (Carboxyesterase ES-10) (Carboxylesterase 3) (EC 3.1.1.1, EC 3.1.1.67) (ES-HVEL) (Fatty acid ethyl ester synthase) (FAEE synthase) (Liver carboxylesterase 10) (pI 6.1 esterase)	Rattus norvegicus (Rat)	acylglycerol catabolic process [GO:0046464]; cellular response to cholesterol [GO:0071397]; cellular response to cold [GO:0070417]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol biosynthetic process [GO:0006695]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; circadian temperature homeostasis [GO:0060086]; cold-induced thermogenesis [GO:0106106]; cytosolic lipolysis [GO:0061725]; epithelial cell differentiation [GO:0030855]; lipid catabolic process [GO:0016042]; medium-chain fatty acid metabolic process [GO:0051791]; negative regulation of cholesterol storage [GO:0010887]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of bile acid secretion [GO:0120188]; response to ethanol [GO:0045471]; retinoid metabolic process [GO:0001523]; reverse cholesterol transport [GO:0043691]; short-chain fatty acid catabolic process [GO:0019626]; very-low-density lipoprotein particle assembly [GO:0034379]	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; fatty-acyl-ethyl-ester synthase activity [GO:0030339]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; retinyl-palmitate esterase activity [GO:0050253]; sterol ester esterase activity [GO:0004771]; triacylglycerol lipase activity [GO:0004806]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; intracellular membrane-bounded organelle [GO:0043231]; lipid droplet [GO:0005811]	GO:0001523; GO:0004771; GO:0004806; GO:0005737; GO:0005783; GO:0005788; GO:0005811; GO:0005829; GO:0006695; GO:0008203; GO:0010875; GO:0010887; GO:0016042; GO:0019626; GO:0030339; GO:0030855; GO:0034379; GO:0042632; GO:0043231; GO:0043691; GO:0045471; GO:0045944; GO:0046464; GO:0047374; GO:0047376; GO:0050253; GO:0051791; GO:0052689; GO:0060086; GO:0061725; GO:0070417; GO:0070857; GO:0071397; GO:0071404; GO:0090205; GO:0106106; GO:0106435; GO:0120188
GN011380	GN011380.1	Q91WU0	31.5	581	575	561	9.42e-71	240	EST1F_MOUSE	Carboxylesterase 1F (EC 3.1.1.1) (Carboxylic ester hydrolase) (Triacylglycerol hydrolase 2) (TGH-2)	Mus musculus (Mouse)	cellular response to cholesterol [GO:0071397]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol biosynthetic process [GO:0006695]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; epithelial cell differentiation [GO:0030855]; medium-chain fatty acid metabolic process [GO:0051791]; negative regulation of cholesterol storage [GO:0010887]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cholesterol metabolic process [GO:0090205]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of bile acid secretion [GO:0120188]; reverse cholesterol transport [GO:0043691]; short-chain fatty acid catabolic process [GO:0019626]	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; carboxylesterase activity [GO:0106435]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; retinyl-palmitate esterase activity [GO:0050253]; sterol ester esterase activity [GO:0004771]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; lipid droplet [GO:0005811]	GO:0004771; GO:0005737; GO:0005783; GO:0005788; GO:0005811; GO:0005829; GO:0006695; GO:0008203; GO:0010875; GO:0010887; GO:0019626; GO:0030855; GO:0042632; GO:0043691; GO:0047374; GO:0047376; GO:0050253; GO:0051791; GO:0070857; GO:0071397; GO:0071404; GO:0090205; GO:0106435; GO:0120188
GN011381	GN011381.1	P30122	32.6	472	468	597	6.33e-65	223	CEL_BOVIN	Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (EC 3.1.1.6) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase)	Bos taurus (Bovine)	ceramide catabolic process [GO:0046514]; pancreatic juice secretion [GO:0030157]	acetylesterase activity [GO:0008126]; FAHFA hydrolase activity [GO:0120573]; retinyl-palmitate esterase activity [GO:0050253]; sterol ester esterase activity [GO:0004771]; triacylglycerol lipase activity [GO:0004806]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	GO:0004771; GO:0004806; GO:0005576; GO:0005737; GO:0008126; GO:0030157; GO:0046514; GO:0050253; GO:0120573
GN011382	GN011382.1	Q8VCT4	34.3	551	566	565	8.43e-78	259	EST1D_MOUSE	Carboxylesterase 1D (Carboxylesterase 3) (EC 3.1.1.1, EC 3.1.1.67) (Fatty acid ethyl ester synthase) (FAEE synthase) (Triacylglycerol hydrolase) (TGH)	Mus musculus (Mouse)	acyl-CoA metabolic process [GO:0006637]; acylglycerol catabolic process [GO:0046464]; cellular response to cold [GO:0070417]; circadian temperature homeostasis [GO:0060086]; cold-induced thermogenesis [GO:0106106]; cytosolic lipolysis [GO:0061725]; lipid catabolic process [GO:0016042]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to toxic substance [GO:0009636]; short-chain fatty acid catabolic process [GO:0019626]; very-low-density lipoprotein particle assembly [GO:0034379]	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; carboxylesterase activity [GO:0106435]; carboxylic ester hydrolase activity [GO:0052689]; fatty-acyl-ethyl-ester synthase activity [GO:0030339]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; retinyl-palmitate esterase activity [GO:0050253]; sterol ester esterase activity [GO:0004771]; triacylglycerol lipase activity [GO:0004806]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; lipid droplet [GO:0005811]	GO:0004771; GO:0004806; GO:0005737; GO:0005783; GO:0005788; GO:0005811; GO:0005829; GO:0006637; GO:0009636; GO:0016042; GO:0019626; GO:0030339; GO:0034379; GO:0045944; GO:0046464; GO:0047374; GO:0047376; GO:0050253; GO:0052689; GO:0060086; GO:0061725; GO:0070417; GO:0106106; GO:0106435
GN011394	GN011394.1	Q75VW3	50.0	66	196	356	9.44e-13	68.9	DNAJ_HYDTT	Chaperone protein DnaJ	Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)	protein refolding [GO:0042026]; response to heat [GO:0009408]	ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005524; GO:0005737; GO:0008270; GO:0009408; GO:0031072; GO:0042026
GN011395	GN011395.1	Q9BSW7	54.9	370	449	474	1.49e-132	393	SYT17_HUMAN	Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII)	Homo sapiens (Human)	positive regulation of dendrite extension [GO:1903861]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; vesicle-mediated transport [GO:0016192]	calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; SNARE binding [GO:0000149]	exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	GO:0000149; GO:0005544; GO:0005886; GO:0016192; GO:0017158; GO:0061891; GO:0070382; GO:0098794; GO:0098978; GO:0099149; GO:1903861
GN011397	GN011397.1	Q5AF03	29.4	170	200	236	2.08e-16	77.8	HSP31_CANAL	Glyoxalase 3 (EC 4.2.1.130) (Glutathione-independent glyoxalase)	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)	methylglyoxal catabolic process [GO:0051596]	glyoxalase III activity [GO:0019172]	fungal biofilm matrix [GO:0062040]; hyphal cell wall [GO:0030446]; yeast-form cell wall [GO:0030445]	GO:0019172; GO:0030445; GO:0030446; GO:0051596; GO:0062040
GN011398	GN011398.1	O35093	31.5	146	219	209	5.48e-16	76.6	TIM23_RAT	Mitochondrial import inner membrane translocase subunit Tim23	Rattus norvegicus (Rat)	intracellular protein transport [GO:0006886]; positive regulation of protein processing [GO:0010954]; protein import into mitochondrial matrix [GO:0030150]; response to 3,3',5-triiodo-L-thyronine [GO:1905242]; type 2 mitophagy [GO:0061734]	transmembrane protein transporter activity [GO:0008320]	migrasome [GO:0140494]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	GO:0005739; GO:0005743; GO:0005744; GO:0005758; GO:0006886; GO:0008320; GO:0010954; GO:0030150; GO:0061734; GO:0140494; GO:1905242
GN011401	GN011401.1	P0CW27	26.3	190	220	439	4.88e-12	67.8	CC166_HUMAN	Coiled-coil domain-containing protein 166	Homo sapiens (Human)				
GN011402	GN011402.1	Q6IPM2	33.9	251	820	695	1.59e-28	125	IQCE_HUMAN	IQ domain-containing protein E	Homo sapiens (Human)	limb morphogenesis [GO:0035108]		ciliary membrane [GO:0060170]; cilium [GO:0005929]	GO:0005929; GO:0035108; GO:0060170
GN011403	GN011403.1	Q9Y5X2	48.5	412	528	465	3.70e-130	390	SNX8_HUMAN	Sorting nexin-8	Homo sapiens (Human)	early endosome to Golgi transport [GO:0034498]; intracellular protein transport [GO:0006886]	identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]	GO:0005829; GO:0006886; GO:0031901; GO:0034498; GO:0035091; GO:0042802
GN011404	GN011404.1	A6NN90	40.9	127	455	582	9.27e-21	98.6	CB081_HUMAN	Uncharacterized protein C2orf81	Homo sapiens (Human)				
GN011405	GN011405.1	Q9H0I2	39.9	258	279	346	5.57e-48	166	ENKD1_HUMAN	Enkurin domain-containing protein 1	Homo sapiens (Human)	establishment of mitotic spindle orientation [GO:0000132]; motile cilium assembly [GO:0044458]; non-motile cilium assembly [GO:1905515]	alpha-tubulin binding [GO:0043014]; microtubule binding [GO:0008017]	9+0 non-motile cilium [GO:0097731]; axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881]; microtubule cytoskeleton [GO:0015630]; spindle pole [GO:0000922]	GO:0000132; GO:0000922; GO:0005813; GO:0005814; GO:0005881; GO:0005929; GO:0005930; GO:0008017; GO:0015630; GO:0036064; GO:0043014; GO:0044458; GO:0097546; GO:0097731; GO:1905515
GN011406	GN011406.1	A0A2K5TU92	35.4	280	391	355	7.29e-41	150	SIR6_MACFA	NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	cardiac muscle cell differentiation [GO:0055007]; circadian regulation of gene expression [GO:0032922]; determination of adult lifespan [GO:0008340]; double-strand break repair [GO:0006302]; ketone biosynthetic process [GO:0042181]; negative regulation of cellular senescence [GO:2000773]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of glycolytic process [GO:0045820]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein localization to chromatin [GO:0120186]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; neuron differentiation [GO:0030182]; pericentric heterochromatin formation [GO:0031508]; positive regulation of blood vessel branching [GO:1905555]; positive regulation of chondrocyte proliferation [GO:1902732]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of insulin secretion [GO:0032024]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein localization to chromatin [GO:0120187]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; protein delipidation [GO:0051697]; protein destabilization [GO:0031648]; protein import into nucleus [GO:0006606]; protein localization to site of double-strand break [GO:1990166]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of lipid catabolic process [GO:0050994]; regulation of lipid metabolic process [GO:0019216]; regulation of protein localization to plasma membrane [GO:1903076]; response to UV [GO:0009411]; subtelomeric heterochromatin formation [GO:0031509]; transposable element silencing [GO:0010526]	chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA damage sensor activity [GO:0140612]; histone H3K18 deacetylase activity, NAD-dependent [GO:0097372]; histone H3K56 deacetylase activity, NAD-dependent [GO:0140765]; histone H3K9 deacetylase activity, NAD-dependent [GO:0046969]; lncRNA binding [GO:0106222]; NAD+ binding [GO:0070403]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD-dependent protein demyristoylase activity [GO:0140773]; NAD-dependent protein depalmitoylase activity [GO:0140774]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; nucleosome binding [GO:0031491]; protein homodimerization activity [GO:0042803]; TORC2 complex binding [GO:1904841]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, subtelomeric region [GO:0099115]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; site of double-strand break [GO:0035861]	GO:0000122; GO:0000785; GO:0003684; GO:0003714; GO:0005634; GO:0005654; GO:0005694; GO:0005721; GO:0005783; GO:0006302; GO:0006606; GO:0008340; GO:0009411; GO:0010526; GO:0010569; GO:0019216; GO:0030182; GO:0031490; GO:0031491; GO:0031508; GO:0031509; GO:0031648; GO:0032024; GO:0032206; GO:0032436; GO:0032922; GO:0034244; GO:0034979; GO:0035861; GO:0042181; GO:0042308; GO:0042752; GO:0042803; GO:0045600; GO:0045721; GO:0045820; GO:0046827; GO:0046969; GO:0050994; GO:0051697; GO:0055007; GO:0070403; GO:0097372; GO:0099115; GO:0106222; GO:0106274; GO:0120162; GO:0120186; GO:0120187; GO:0140612; GO:0140765; GO:0140773; GO:0140774; GO:0140804; GO:1902459; GO:1902732; GO:1903076; GO:1904841; GO:1905555; GO:1905564; GO:1990166; GO:2000738; GO:2000773; GO:2000781
GN011407	GN011407.1	Q7XWV4	39.2	240	387	483	2.79e-41	154	SRT1_ORYSJ	NAD-dependent protein deacetylase SRT1 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (OsSRT1)	Oryza sativa subsp. japonica (Rice)	negative regulation of transcription by RNA polymerase II [GO:0000122]	histone deacetylase activity, NAD-dependent [GO:0017136]; NAD+ binding [GO:0070403]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]	GO:0000122; GO:0003714; GO:0005634; GO:0017136; GO:0034979; GO:0070403
GN011408	GN011408.1	Q04432	32.6	239	229	237	2.25e-30	115	HSP31_YEAST	Glutathione-independent glyoxalase HSP31 (EC 4.2.1.130) (Glyoxalase 3 homolog 1) (Heat shock protein 31)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	cellular response to nutrient levels [GO:0031669]; cellular response to oxidative stress [GO:0034599]; protein folding [GO:0006457]	glyoxalase III activity [GO:0019172]; protein folding chaperone [GO:0044183]	cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932]	GO:0000932; GO:0006457; GO:0010494; GO:0019172; GO:0031669; GO:0034599; GO:0044183
GN011409	GN011409.1	Q09621	41.3	80	113	473	1.28e-12	65.9	LACT2_CAEEL	Beta-lactamase domain-containing protein 2	Caenorhabditis elegans			membrane [GO:0016020]	GO:0016020
GN011411	GN011411.1	Q96DM1	26.3	133	161	585	2.74e-13	69.7	PGBD4_HUMAN	PiggyBac transposable element-derived protein 4	Homo sapiens (Human)				
GN011414	GN011414.1	Q99020	48.0	179	326	285	7.83e-46	160	ROAA_MOUSE	Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A)	Mus musculus (Mouse)	chromosomal 5-methylcytosine DNA demethylation pathway [GO:0141166]; epithelial to mesenchymal transition [GO:0001837]; mRNA modification [GO:0016556]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cellular localization [GO:0060341]; regulation of gene expression [GO:0010468]; regulation of intracellular mRNA localization [GO:1904580]	protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; mRNA editing complex [GO:0045293]; neuronal ribonucleoprotein granule [GO:0071598]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; presynaptic cytosol [GO:0099523]; ribonucleoprotein complex [GO:1990904]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000785; GO:0001837; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0010468; GO:0016556; GO:0030425; GO:0044877; GO:0045293; GO:0045893; GO:0060341; GO:0071598; GO:0090575; GO:0098794; GO:0098978; GO:0099523; GO:0141166; GO:1904580; GO:1990837; GO:1990904; GO:2000623
GN011415	GN011415.1	Q6GPV5	49.1	165	157	156	2.87e-47	153	RN181_XENLA	E3 ubiquitin-protein ligase RNF181 (EC 2.3.2.27) (RING finger protein 181)	Xenopus laevis (African clawed frog)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]	GO:0005737; GO:0016567; GO:0061630
GN011416	GN011416.1	A7RZS0	48.6	107	133	171	5.82e-31	111	BL1S2_NEMVE	Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC-1 subunit 2)	Nematostella vectensis (Starlet sea anemone)	endosomal transport [GO:0016197]; lysosome localization [GO:0032418]	gamma-tubulin binding [GO:0043015]	BLOC-1 complex [GO:0031083]; BORC complex [GO:0099078]; centrosome [GO:0005813]; gamma-tubulin complex [GO:0000930]; lysosomal membrane [GO:0005765]	GO:0000930; GO:0005765; GO:0005813; GO:0016197; GO:0031083; GO:0032418; GO:0043015; GO:0099078
GN011417	GN011417.1	O93327	60.6	378	376	369	2.71e-134	391	H2AY_CHICK	Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y)	Gallus gallus (Chicken)	heterochromatin formation [GO:0031507]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; nucleosome assembly [GO:0006334]; regulation of NAD metabolic process [GO:1902688]	ADP-D-ribose binding [GO:0072570]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; structural constituent of chromatin [GO:0030527]	chromosome [GO:0005694]; nucleosome [GO:0000786]; nucleus [GO:0005634]	GO:0000122; GO:0000786; GO:0003677; GO:0005634; GO:0005694; GO:0006334; GO:0030527; GO:0031507; GO:0046982; GO:0072570; GO:0160002; GO:1901837; GO:1902688
GN011418	GN011418.1	Q9VE46	60.8	457	493	614	1.49e-186	538	SC5A7_DROME	High-affinity choline transporter 1	Drosophila melanogaster (Fruit fly)	acetylcholine biosynthetic process [GO:0008292]; amino acid transmembrane transport [GO:0003333]; choline transport [GO:0015871]	amino acid transmembrane transporter activity [GO:0015171]; choline transmembrane transporter activity [GO:0015220]; choline:sodium symporter activity [GO:0005307]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0003333; GO:0005307; GO:0005886; GO:0008292; GO:0015171; GO:0015220; GO:0015871; GO:0016020
GN011424	GN011424.1	Q96DM1	31.7	104	105	585	1.97e-15	73.6	PGBD4_HUMAN	PiggyBac transposable element-derived protein 4	Homo sapiens (Human)				
GN011427	GN011427.1	Q9VE46	60.2	98	160	614	2.39e-32	124	SC5A7_DROME	High-affinity choline transporter 1	Drosophila melanogaster (Fruit fly)	acetylcholine biosynthetic process [GO:0008292]; amino acid transmembrane transport [GO:0003333]; choline transport [GO:0015871]	amino acid transmembrane transporter activity [GO:0015171]; choline transmembrane transporter activity [GO:0015220]; choline:sodium symporter activity [GO:0005307]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0003333; GO:0005307; GO:0005886; GO:0008292; GO:0015171; GO:0015220; GO:0015871; GO:0016020
GN011428	GN011428.1	Q9VE46	58.3	403	436	614	4.99e-156	457	SC5A7_DROME	High-affinity choline transporter 1	Drosophila melanogaster (Fruit fly)	acetylcholine biosynthetic process [GO:0008292]; amino acid transmembrane transport [GO:0003333]; choline transport [GO:0015871]	amino acid transmembrane transporter activity [GO:0015171]; choline transmembrane transporter activity [GO:0015220]; choline:sodium symporter activity [GO:0005307]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0003333; GO:0005307; GO:0005886; GO:0008292; GO:0015171; GO:0015220; GO:0015871; GO:0016020
GN011435	GN011435.1	Q9UNS2	69.8	414	425	423	1.54e-207	581	CSN3_HUMAN	COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)	Homo sapiens (Human)	positive regulation of keratinocyte differentiation [GO:0045618]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of protein neddylation [GO:2000434]; response to light stimulus [GO:0009416]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]		cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0000338; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005911; GO:0006511; GO:0007165; GO:0008180; GO:0009416; GO:0043516; GO:0045116; GO:0045618; GO:0048471; GO:2000434
GN011436	GN011436.1	Q4KLB0	69.6	125	142	160	1.11e-60	187	GLOD5_XENLA	Glyoxalase domain-containing protein 5	Xenopus laevis (African clawed frog)				
GN011437	GN011437.1	P39153	31.2	199	840	346	3.45e-18	90.5	SUA5_BACSU	Threonylcarbamoyl-AMP synthase (TC-AMP synthase) (EC 2.7.7.87) (L-threonylcarbamoyladenylate synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC) (tRNA threonylcarbamoyladenosine biosynthesis protein YwlC)	Bacillus subtilis (strain 168)	regulation of translational fidelity [GO:0006450]; tRNA threonylcarbamoyladenosine modification [GO:0002949]	ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; L-threonylcarbamoyladenylate synthase activity [GO:0061710]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]	GO:0000049; GO:0002949; GO:0003725; GO:0005524; GO:0005737; GO:0006450; GO:0016779; GO:0061710
GN011438	GN011438.1	P45831	24.0	204	850	220	2.91e-09	61.6	TSAC_MYCLE	Putative threonylcarbamoyl-AMP synthase (TC-AMP synthase) (EC 2.7.7.87) (L-threonylcarbamoyladenylate synthase) (tRNA threonylcarbamoyladenosine biosynthesis protein ML1136)	Mycobacterium leprae (strain TN)	regulation of translational fidelity [GO:0006450]	double-stranded RNA binding [GO:0003725]; L-threonylcarbamoyladenylate synthase activity [GO:0061710]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]	GO:0000049; GO:0003725; GO:0005737; GO:0006450; GO:0061710
GN011439	GN011439.1	A6NK06	45.1	446	498	481	2.07e-128	385	IRG1_HUMAN	Cis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein)	Homo sapiens (Human)	cellular response to cocaine [GO:0071314]; cellular response to interferon-beta [GO:0035458]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to molecule of bacterial origin [GO:0071219]; cellular response to progesterone stimulus [GO:0071393]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; defense response [GO:0006952]; defense response to virus [GO:0051607]; embryo implantation [GO:0007566]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of type I interferon production [GO:0032480]; positive regulation of antimicrobial humoral response [GO:0002760]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; tolerance induction to lipopolysaccharide [GO:0072573]	aconitate decarboxylase activity [GO:0047613]; protein homodimerization activity [GO:0042803]	mitochondrion [GO:0005739]	GO:0002760; GO:0005739; GO:0006952; GO:0007566; GO:0032480; GO:0034136; GO:0034144; GO:0035458; GO:0042803; GO:0045824; GO:0047613; GO:0050728; GO:0051607; GO:0071219; GO:0071222; GO:0071314; GO:0071346; GO:0071347; GO:0071356; GO:0071393; GO:0072573; GO:2000379
GN011440	GN011440.1	Q9ZVF6	38.5	96	148	283	4.81e-09	56.6	PAHX_ARATH	Phytanoyl-CoA dioxygenase (EC 1.14.11.18) (Phytanoyl-CoA 2-hydroxylase)	Arabidopsis thaliana (Mouse-ear cress)	fatty acid metabolic process [GO:0006631]	phytanoyl-CoA dioxygenase activity [GO:0048244]	cytoplasmic stress granule [GO:0010494]	GO:0006631; GO:0010494; GO:0048244
GN011441	GN011441.1	Q9NWT6	58.4	317	328	349	3.67e-139	400	HIF1N_HUMAN	Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase)	Homo sapiens (Human)	negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of vasculogenesis [GO:2001214]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]	[protein]-asparagine 3-dioxygenase activity [GO:0036140]; ankyrin repeat binding [GO:0071532]; carboxylic acid binding [GO:0031406]; ferrous iron binding [GO:0008198]; NF-kappaB binding [GO:0051059]; Notch binding [GO:0005112]; oxygen sensor activity [GO:0019826]; peptidyl-aspartic acid 3-dioxygenase activity [GO:0062101]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein homodimerization activity [GO:0042803]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	GO:0000122; GO:0003714; GO:0005112; GO:0005654; GO:0005737; GO:0005829; GO:0008198; GO:0008270; GO:0019826; GO:0030947; GO:0031406; GO:0036139; GO:0036140; GO:0042803; GO:0045663; GO:0045746; GO:0048471; GO:0051059; GO:0061629; GO:0062101; GO:0071532; GO:2001214
GN011443	GN011443.1	D3YZP9	68.4	351	417	469	2.12e-58	201	CCDC6_MOUSE	Coiled-coil domain-containing protein 6	Mus musculus (Mouse)		identical protein binding [GO:0042802]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]	GO:0005829; GO:0005856; GO:0042802
GN011444	GN011444.1	A6HD62	58.7	281	278	304	4.53e-109	320	CHIP_RAT	E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)	Rattus norvegicus (Rat)	cellular response to heat [GO:0034605]; cellular response to hypoxia [GO:0071456]; cellular response to misfolded protein [GO:0071218]; chaperone-mediated autophagy [GO:0061684]; endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular associated smooth muscle contraction [GO:1904694]; positive regulation of chaperone-mediated protein complex assembly [GO:0090035]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of mitophagy [GO:1901526]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of proteolysis [GO:0045862]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of glucocorticoid metabolic process [GO:0031943]; regulation of protein stability [GO:0031647]; response to ischemia [GO:0002931]; ubiquitin-dependent protein catabolic process [GO:0006511]	enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; kinase binding [GO:0019900]; misfolded protein binding [GO:0051787]; protein homodimerization activity [GO:0042803]; protein-folding chaperone binding [GO:0051087]; R-SMAD binding [GO:0070412]; SMAD binding [GO:0046332]; TPR domain binding [GO:0030911]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; ubiquitin ligase complex [GO:0000151]; Z disc [GO:0030018]	GO:0000151; GO:0000165; GO:0000209; GO:0001664; GO:0002931; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005783; GO:0005829; GO:0006511; GO:0006513; GO:0006515; GO:0010614; GO:0016567; GO:0019899; GO:0019900; GO:0030018; GO:0030512; GO:0030544; GO:0030911; GO:0030968; GO:0031072; GO:0031398; GO:0031625; GO:0031647; GO:0031943; GO:0032436; GO:0034392; GO:0034393; GO:0034450; GO:0034605; GO:0035359; GO:0036503; GO:0042405; GO:0042803; GO:0043066; GO:0043161; GO:0045862; GO:0046332; GO:0050821; GO:0051087; GO:0051787; GO:0051865; GO:0051879; GO:0061630; GO:0061684; GO:0070412; GO:0070534; GO:0071218; GO:0071456; GO:0090035; GO:0101031; GO:1901526; GO:1904294; GO:1904694
GN011446	GN011446.1	Q8IVG5	31.9	144	1702	1584	1.90e-10	70.1	SAM9L_HUMAN	Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like)	Homo sapiens (Human)			cytoplasm [GO:0005737]; early endosome [GO:0005769]; mitochondrion [GO:0005739]	GO:0005737; GO:0005739; GO:0005769
GN011449	GN011449.1	Q1LZD0	28.5	319	307	332	2.44e-20	92.8	AA2BR_BOVIN	Adenosine receptor A2b	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; vasodilation [GO:0042311]	G protein-coupled adenosine receptor activity [GO:0001609]	plasma membrane [GO:0005886]	GO:0001609; GO:0005886; GO:0007189; GO:0042311
GN011454	GN011454.1	Q9UNS2	69.8	414	425	423	5.38e-208	582	CSN3_HUMAN	COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)	Homo sapiens (Human)	positive regulation of keratinocyte differentiation [GO:0045618]; protein deneddylation [GO:0000338]; protein neddylation [GO:0045116]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of protein neddylation [GO:2000434]; response to light stimulus [GO:0009416]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]		cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0000338; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005911; GO:0006511; GO:0007165; GO:0008180; GO:0009416; GO:0043516; GO:0045116; GO:0045618; GO:0048471; GO:2000434
GN011456	GN011456.1	Q4KLB0	70.4	125	142	160	1.92e-61	189	GLOD5_XENLA	Glyoxalase domain-containing protein 5	Xenopus laevis (African clawed frog)				
GN011457	GN011457.1	P39153	34.0	153	797	346	2.98e-13	75.5	SUA5_BACSU	Threonylcarbamoyl-AMP synthase (TC-AMP synthase) (EC 2.7.7.87) (L-threonylcarbamoyladenylate synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC) (tRNA threonylcarbamoyladenosine biosynthesis protein YwlC)	Bacillus subtilis (strain 168)	regulation of translational fidelity [GO:0006450]; tRNA threonylcarbamoyladenosine modification [GO:0002949]	ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; L-threonylcarbamoyladenylate synthase activity [GO:0061710]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]	GO:0000049; GO:0002949; GO:0003725; GO:0005524; GO:0005737; GO:0006450; GO:0016779; GO:0061710
GN011458	GN011458.1	P45831	24.0	204	814	220	2.76e-09	61.6	TSAC_MYCLE	Putative threonylcarbamoyl-AMP synthase (TC-AMP synthase) (EC 2.7.7.87) (L-threonylcarbamoyladenylate synthase) (tRNA threonylcarbamoyladenosine biosynthesis protein ML1136)	Mycobacterium leprae (strain TN)	regulation of translational fidelity [GO:0006450]	double-stranded RNA binding [GO:0003725]; L-threonylcarbamoyladenylate synthase activity [GO:0061710]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]	GO:0000049; GO:0003725; GO:0005737; GO:0006450; GO:0061710
GN011459	GN011459.1	A6NK06	44.8	446	498	481	5.85e-128	384	IRG1_HUMAN	Cis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein)	Homo sapiens (Human)	cellular response to cocaine [GO:0071314]; cellular response to interferon-beta [GO:0035458]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to molecule of bacterial origin [GO:0071219]; cellular response to progesterone stimulus [GO:0071393]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; defense response [GO:0006952]; defense response to virus [GO:0051607]; embryo implantation [GO:0007566]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of type I interferon production [GO:0032480]; positive regulation of antimicrobial humoral response [GO:0002760]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; tolerance induction to lipopolysaccharide [GO:0072573]	aconitate decarboxylase activity [GO:0047613]; protein homodimerization activity [GO:0042803]	mitochondrion [GO:0005739]	GO:0002760; GO:0005739; GO:0006952; GO:0007566; GO:0032480; GO:0034136; GO:0034144; GO:0035458; GO:0042803; GO:0045824; GO:0047613; GO:0050728; GO:0051607; GO:0071219; GO:0071222; GO:0071314; GO:0071346; GO:0071347; GO:0071356; GO:0071393; GO:0072573; GO:2000379
GN011460	GN011460.1	A6NK06	44.6	446	498	481	4.13e-128	384	IRG1_HUMAN	Cis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein)	Homo sapiens (Human)	cellular response to cocaine [GO:0071314]; cellular response to interferon-beta [GO:0035458]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to molecule of bacterial origin [GO:0071219]; cellular response to progesterone stimulus [GO:0071393]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; defense response [GO:0006952]; defense response to virus [GO:0051607]; embryo implantation [GO:0007566]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of type I interferon production [GO:0032480]; positive regulation of antimicrobial humoral response [GO:0002760]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; tolerance induction to lipopolysaccharide [GO:0072573]	aconitate decarboxylase activity [GO:0047613]; protein homodimerization activity [GO:0042803]	mitochondrion [GO:0005739]	GO:0002760; GO:0005739; GO:0006952; GO:0007566; GO:0032480; GO:0034136; GO:0034144; GO:0035458; GO:0042803; GO:0045824; GO:0047613; GO:0050728; GO:0051607; GO:0071219; GO:0071222; GO:0071314; GO:0071346; GO:0071347; GO:0071356; GO:0071393; GO:0072573; GO:2000379
GN011461	GN011461.1	O18778	26.1	226	259	337	7.30e-14	73.6	PAHX_BOVIN	Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH)	Bos taurus (Bovine)	fatty acid alpha-oxidation [GO:0001561]	phytanoyl-CoA dioxygenase activity [GO:0048244]	peroxisome [GO:0005777]	GO:0001561; GO:0005777; GO:0048244
GN011464	GN011464.1	Q3UMF9	35.5	242	280	409	2.25e-48	168	FAXC_MOUSE	Failed axon connections homolog	Mus musculus (Mouse)			membrane [GO:0016020]	GO:0016020
GN011465	GN011465.1	Q6DGM1	57.7	97	119	155	8.32e-29	105	UBAD1_DANRE	UBA-like domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)				
GN011466	GN011466.1	Q3TEL6	49.5	440	640	685	6.52e-123	382	RN157_MOUSE	E3 ubiquitin ligase Rnf157 (EC 2.3.2.27) (RING finger protein 157) (RING-type E3 ubiquitin transferase Rnf157)	Mus musculus (Mouse)	negative regulation of apoptotic process [GO:0043066]; positive regulation of dendrite extension [GO:1903861]; protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]	GO:0005737; GO:0016567; GO:0031410; GO:0043066; GO:0044297; GO:0061630; GO:1903861
GN011471	GN011471.1	Q3UMF9	34.5	249	266	409	2.53e-38	141	FAXC_MOUSE	Failed axon connections homolog	Mus musculus (Mouse)			membrane [GO:0016020]	GO:0016020
GN011472	GN011472.1	Q6GPB5	71.8	177	235	360	1.11e-93	281	ALKB5_XENLA	RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5)	Xenopus laevis (African clawed frog)	membraneless organelle assembly [GO:0140694]; mRNA destabilization [GO:0061157]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; regulation of translation [GO:0006417]; response to hypoxia [GO:0001666]; spermatogenesis [GO:0007283]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; molecular condensate scaffold activity [GO:0140693]; mRNA N6-methyladenosine dioxygenase activity [GO:1990931]; oxidative RNA demethylase activity [GO:0035515]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; paraspeckles [GO:0042382]	GO:0001666; GO:0005634; GO:0006397; GO:0006406; GO:0006417; GO:0007283; GO:0010793; GO:0016607; GO:0016706; GO:0035515; GO:0042382; GO:0050684; GO:0061157; GO:0140693; GO:0140694; GO:1990931
GN011473	GN011473.1	Q9D882	37.6	117	139	120	3.98e-13	64.7	F241B_MOUSE	Protein FAM241B	Mus musculus (Mouse)			membrane [GO:0016020]	GO:0016020
GN011474	GN011474.1	Q9HD45	75.4	431	448	589	7.45e-245	683	TM9S3_HUMAN	Transmembrane 9 superfamily member 3 (EP70-P-iso) (SM-11044-binding protein)	Homo sapiens (Human)	protein localization to membrane [GO:0072657]		membrane [GO:0016020]	GO:0016020; GO:0072657
GN011475	GN011475.1	Q9HD45	70.1	177	181	589	2.92e-89	275	TM9S3_HUMAN	Transmembrane 9 superfamily member 3 (EP70-P-iso) (SM-11044-binding protein)	Homo sapiens (Human)	protein localization to membrane [GO:0072657]		membrane [GO:0016020]	GO:0016020; GO:0072657
GN011476	GN011476.1	Q9ET30	86.6	82	83	587	7.81e-45	154	TM9S3_MOUSE	Transmembrane 9 superfamily member 3	Mus musculus (Mouse)	protein localization to membrane [GO:0072657]		membrane [GO:0016020]	GO:0016020; GO:0072657
GN011477	GN011477.1	Q9IBD8	38.6	241	642	1216	6.01e-42	167	PTPRC_CYPCA	Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (CD antigen CD45)	Cyprinus carpio (Common carp)	T cell receptor signaling pathway [GO:0050852]	protein tyrosine phosphatase activity [GO:0004725]	plasma membrane [GO:0005886]	GO:0004725; GO:0005886; GO:0050852
GN011491	GN011491.1	Q9VR50	48.0	252	325	373	9.35e-58	193	S35E1_DROME	Solute carrier family 35 member E1 homolog	Drosophila melanogaster (Fruit fly)	transmembrane transport [GO:0055085]	transmembrane transporter activity [GO:0022857]	endomembrane system [GO:0012505]; membrane [GO:0016020]	GO:0012505; GO:0016020; GO:0022857; GO:0055085
GN011493	GN011493.1	Q6NY34	74.9	171	204	197	4.50e-89	263	AS1BB_DANRE	Histone chaperone asf1b-B (Anti-silencing function protein 1 homolog Bb)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA replication-dependent chromatin assembly [GO:0006335]	histone binding [GO:0042393]	nucleus [GO:0005634]	GO:0005634; GO:0006335; GO:0042393
GN011494	GN011494.1	Q95JP0	49.0	870	947	891	2.85e-291	833	DNAI3_MACFA	Dynein axonemal intermediate chain 3 (WD repeat-containing protein 63)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	cilium movement involved in cell motility [GO:0060294]; inner dynein arm assembly [GO:0036159]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of cell migration [GO:0030336]; positive regulation of osteoblast differentiation [GO:0045669]	Arp2/3 complex binding [GO:0071933]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]	axonemal dynein complex [GO:0005858]; cytoplasm [GO:0005737]; inner dynein arm [GO:0036156]	GO:0005737; GO:0005858; GO:0030336; GO:0034316; GO:0036156; GO:0036159; GO:0045503; GO:0045504; GO:0045669; GO:0060294; GO:0071933
GN011495	GN011495.1	Q8VBT9	32.0	572	618	550	2.22e-64	224	ASPC1_MOUSE	Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog)	Mus musculus (Mouse)	glucose homeostasis [GO:0042593]; intracellular protein transport [GO:0006886]; peptidyl-lysine trimethylation [GO:0018023]; positive regulation of protein modification process [GO:0031401]; regulation of D-glucose import across plasma membrane [GO:0046324]	methyltransferase regulator activity [GO:0141107]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; intracellular protein-containing complex [GO:0140535]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006886; GO:0009898; GO:0012505; GO:0012506; GO:0018023; GO:0030659; GO:0031401; GO:0033116; GO:0042593; GO:0046324; GO:0048471; GO:0140535; GO:0141107
GN011496	GN011496.1	Q03468	43.5	1496	1451	1493	0.0	950	ERCC6_HUMAN	DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)	Homo sapiens (Human)	base-excision repair [GO:0006284]; chromatin remodeling [GO:0006338]; DNA damage checkpoint signaling [GO:0000077]; DNA protection [GO:0042262]; DNA repair [GO:0006281]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription by RNA polymerase III [GO:0045945]; protein localization to chromatin [GO:0071168]; regulation of DNA-templated transcription elongation [GO:0032784]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; response to oxidative stress [GO:0006979]; single strand break repair [GO:0000012]; transcription by RNA polymerase II [GO:0006366]; transcription-coupled nucleotide-excision repair [GO:0006283]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP-dependent DNA damage sensor activity [GO:0140664]; chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; DNA binding [GO:0003677]; protein tyrosine kinase activator activity [GO:0030296]; RNA polymerase binding [GO:0070063]	B-WICH complex [GO:0110016]; chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; transcription elongation factor complex [GO:0008023]	GO:0000012; GO:0000077; GO:0003677; GO:0003682; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0006281; GO:0006283; GO:0006284; GO:0006338; GO:0006366; GO:0006979; GO:0008023; GO:0008094; GO:0016604; GO:0016887; GO:0022008; GO:0030182; GO:0030296; GO:0031175; GO:0032784; GO:0032786; GO:0034243; GO:0042262; GO:0045739; GO:0045943; GO:0045944; GO:0045945; GO:0070063; GO:0071168; GO:0090734; GO:0097680; GO:0110016; GO:0140463; GO:0140658; GO:0140664; GO:1905168; GO:2001033
GN011497	GN011497.1	Q09621	31.4	401	425	473	1.24e-61	209	LACT2_CAEEL	Beta-lactamase domain-containing protein 2	Caenorhabditis elegans			membrane [GO:0016020]	GO:0016020
GN011498	GN011498.1	Q9D3D9	45.7	151	171	168	2.50e-31	114	ATPD_MOUSE	ATP synthase F(1) complex subunit delta, mitochondrial (ATP synthase F1 subunit delta) (F-ATPase delta subunit)	Mus musculus (Mouse)	aerobic respiration [GO:0009060]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; proton motive force-driven ATP synthesis [GO:0015986]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]; proton transmembrane transport [GO:1902600]	protein-containing complex binding [GO:0044877]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; structural molecule activity [GO:0005198]	centriole [GO:0005814]; mitochondrial envelope [GO:0005740]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex [GO:0045259]; sperm head-tail coupling apparatus [GO:0120212]; sperm principal piece [GO:0097228]	GO:0005198; GO:0005739; GO:0005740; GO:0005743; GO:0005814; GO:0009060; GO:0015078; GO:0015986; GO:0033615; GO:0042776; GO:0044877; GO:0045259; GO:0046933; GO:0097228; GO:0120212; GO:1902600
GN011499	GN011499.1	Q6QI06	30.9	1051	1031	1708	1.40e-113	389	RICTR_MOUSE	Rapamycin-insensitive companion of mTOR (AVO3 homolog) (mAVO3) (Protein pianissimo)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; cellular response to nutrient levels [GO:0031669]; cGAS/STING signaling pathway [GO:0140896]; cytoskeleton organization [GO:0007010]; embryo development ending in birth or egg hatching [GO:0009792]; lipid biosynthetic process [GO:0008610]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of TOR signaling [GO:0032008]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of establishment of cell polarity [GO:2000114]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]; regulation of phosphorylation [GO:0042325]; regulation of protein phosphorylation [GO:0001932]; TORC2 signaling [GO:0038203]	ATP binding [GO:0005524]; enzyme-substrate adaptor activity [GO:0140767]; molecular adaptor activity [GO:0060090]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; ribosome binding [GO:0043022]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; serine/threonine protein kinase complex [GO:1902554]; TORC2 complex [GO:0031932]	GO:0001932; GO:0001938; GO:0004674; GO:0005524; GO:0005764; GO:0005765; GO:0005783; GO:0005789; GO:0005886; GO:0007010; GO:0008270; GO:0008610; GO:0009792; GO:0010468; GO:0019901; GO:0030036; GO:0030307; GO:0030335; GO:0030838; GO:0031669; GO:0031932; GO:0032008; GO:0032956; GO:0033135; GO:0038203; GO:0042325; GO:0043022; GO:0043066; GO:0043491; GO:0043539; GO:0050727; GO:0050731; GO:0051896; GO:0051897; GO:0060090; GO:0140767; GO:0140896; GO:0160049; GO:1902554; GO:2000114
GN011500	GN011500.1	Q7SIG4	59.7	308	308	314	4.43e-148	421	DFPA_LOLVU	Diisopropyl-fluorophosphatase (DFPase) (EC 3.8.2.2)	Loligo vulgaris (Common European squid)		calcium ion binding [GO:0005509]; diisopropyl-fluorophosphatase activity [GO:0047862]		GO:0005509; GO:0047862
GN011503	GN011503.1	P0C7U4	27.0	304	325	361	2.89e-13	73.2	C3AR_DANRE	C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R)	Danio rerio (Zebrafish) (Brachydanio rerio)	complement receptor mediated signaling pathway [GO:0002430]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	complement component C5a receptor activity [GO:0004878]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]	GO:0002430; GO:0004878; GO:0004930; GO:0005886; GO:0006954; GO:0007200; GO:0007204
GN011504	GN011504.1	Q8K0U4	27.2	346	341	675	1.22e-35	140	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN011505	GN011505.1	Q8K0U4	32.1	639	615	675	1.05e-89	295	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN011506	GN011506.1	Q8K0U4	28.2	642	588	675	2.65e-67	234	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN011518	GN011518.1	Q15262	41.0	256	543	1439	5.79e-53	197	PTPRK_HUMAN	Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)	Homo sapiens (Human)	cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]	beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; organelle [GO:0043226]; plasma membrane [GO:0005886]	GO:0004725; GO:0005001; GO:0005886; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016020; GO:0016477; GO:0019901; GO:0030054; GO:0030336; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043226; GO:0045295; GO:0045786; GO:0045892; GO:0048041
GN011540	GN011540.1	Q5FWI3	30.4	1170	1118	1383	1.62e-126	423	CEIP2_MOUSE	Cell surface hyaluronidase (EC 3.2.1.35) (Cell migration-inducing hyaluronidase 2) (Transmembrane protein 2)	Mus musculus (Mouse)	hyaluronan catabolic process [GO:0030214]; regulation of sprouting angiogenesis [GO:1903670]	calcium ion binding [GO:0005509]; hyalurononglucosaminidase activity [GO:0004415]	cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	GO:0004415; GO:0005509; GO:0005730; GO:0005829; GO:0005886; GO:0030214; GO:1903670
GN011543	GN011543.1	Q95ZJ1	41.8	510	604	626	1.02e-137	417	GALT5_CAEEL	Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5)	Caenorhabditis elegans	IRE1-mediated unfolded protein response [GO:0036498]; protein O-linked glycosylation [GO:0006493]	polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0004653; GO:0005794; GO:0006493; GO:0036498
GN011544	GN011544.1	Q96PF2	34.4	218	269	358	7.26e-31	120	TSSK2_HUMAN	Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B)	Homo sapiens (Human)	protein autophosphorylation [GO:0046777]; spermatid development [GO:0007286]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000287; GO:0001669; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005814; GO:0007286; GO:0044877; GO:0046777; GO:0106310
GN011557	GN011557.1	P49842	44.4	223	268	254	4.20e-62	199	WHR1_HUMAN	Winged helix repair factor 1 (Inactive serine/threonine-protein kinase 19) (Protein G11) (Protein RP1) (Tandem winged helix protein formerly known as STK19)	Homo sapiens (Human)	positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of single strand break repair [GO:1903518]	double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0003690; GO:0003725; GO:0005634; GO:0005737; GO:0016607; GO:0042803; GO:0046579; GO:1903518
GN011558	GN011558.1	Q8IYH5	46.0	433	452	903	2.73e-108	343	ZZZ3_HUMAN	ZZ-type zinc finger-containing protein 3	Homo sapiens (Human)	chromatin organization [GO:0006325]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	histone binding [GO:0042393]; zinc ion binding [GO:0008270]	ATAC complex [GO:0140672]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005730; GO:0006325; GO:0006355; GO:0006357; GO:0008270; GO:0042393; GO:0045995; GO:0051302; GO:0051726; GO:0072686; GO:0090043; GO:0140672
GN011560	GN011560.1	Q8C0T1	24.4	624	642	654	1.46e-27	121	FM1AB_MOUSE	Protein fem-1 homolog A-like (FEM1-alpha-B) (Protein fem-1 homolog A-B) (FEM1a-B)	Mus musculus (Mouse)	MAPK cascade [GO:0000165]; negative regulation of inflammatory response [GO:0050728]; positive regulation of inflammatory response [GO:0050729]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	EP4 subtype prostaglandin E2 receptor binding [GO:0031867]; molecular adaptor activity [GO:0060090]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000165; GO:0005654; GO:0005737; GO:0005739; GO:0005794; GO:0016567; GO:0031462; GO:0031867; GO:0043161; GO:0050728; GO:0050729; GO:0060090; GO:0140627; GO:1990756
GN011561	GN011561.1	Q8BG81	36.6	145	493	420	9.23e-16	82.8	PDIP3_MOUSE	Polymerase delta-interacting protein 3 (S6K1 Aly/REF-like target) (SKAR)	Mus musculus (Mouse)	poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of translation [GO:0045727]	protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]	GO:0003723; GO:0016607; GO:0016973; GO:0036464; GO:0044877; GO:0045727
GN011562	GN011562.1	Q9D6D0	57.9	195	226	322	1.87e-70	221	UCP4_MOUSE	Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25, member 27)	Mus musculus (Mouse)	inner ear development [GO:0048839]; intracellular triglyceride homeostasis [GO:0035356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell population proliferation [GO:0008284]; regulation of D-glucose import across plasma membrane [GO:0046324]; response to cold [GO:0009409]	chloride transmembrane transporter activity [GO:0015108]; protein homodimerization activity [GO:0042803]; proton transmembrane transporter activity [GO:0015078]	apical part of cell [GO:0045177]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]	GO:0005739; GO:0005743; GO:0008284; GO:0009409; GO:0010917; GO:0015078; GO:0015108; GO:0035356; GO:0042803; GO:0043005; GO:0043025; GO:0043066; GO:0043524; GO:0045177; GO:0046324; GO:0048839; GO:0051562
GN011563	GN011563.1	Q6YKA8	51.8	112	118	211	4.51e-37	127	DRK_DROSI	Protein E(sev)2B (Downstream of receptor kinase) (Protein enhancer of sevenless 2B) (SH2-SH3 adapter protein drk)	Drosophila simulans (Fruit fly)	epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell migration, open tracheal system [GO:0007427]; fibroblast growth factor receptor signaling pathway [GO:0008543]; follicle cell of egg chamber development [GO:0030707]; imaginal disc-derived wing morphogenesis [GO:0007476]; insulin receptor signaling pathway [GO:0008286]; olfactory learning [GO:0008355]; positive regulation of cell size [GO:0045793]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of TORC1 signaling [GO:1904263]; Ras protein signal transduction [GO:0007265]; sensory perception of sound [GO:0007605]; sevenless signaling pathway [GO:0045500]; short-term memory [GO:0007614]; torso signaling pathway [GO:0008293]; tracheal outgrowth, open tracheal system [GO:0007426]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	epidermal growth factor receptor binding [GO:0005154]; phosphotyrosine residue binding [GO:0001784]; sevenless binding [GO:0005118]; signaling receptor complex adaptor activity [GO:0030159]	plasma membrane [GO:0005886]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]	GO:0001784; GO:0005118; GO:0005154; GO:0005886; GO:0007173; GO:0007265; GO:0007426; GO:0007427; GO:0007476; GO:0007605; GO:0007614; GO:0008286; GO:0008293; GO:0008355; GO:0008543; GO:0030159; GO:0030707; GO:0032991; GO:0045500; GO:0045793; GO:0048010; GO:0048260; GO:0070374; GO:0098793; GO:1904263
GN011565	GN011565.1	Q5F1R6	41.0	564	539	531	8.50e-104	325	DJC21_HUMAN	DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3)	Homo sapiens (Human)	protein folding [GO:0006457]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribosome [GO:0005840]	GO:0003723; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005840; GO:0006457; GO:0008270
GN011568	GN011568.1	Q63787	38.9	615	891	724	1.66e-105	345	P85A_RAT	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)	Rattus norvegicus (Rat)	B cell differentiation [GO:0030183]; cellular response to fatty acid [GO:0071398]; cellular response to insulin stimulus [GO:0032869]; cellular response to UV [GO:0034644]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; glucose metabolic process [GO:0006006]; growth hormone receptor signaling pathway [GO:0060396]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; interleukin-18-mediated signaling pathway [GO:0035655]; intracellular glucose homeostasis [GO:0001678]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of heart rate [GO:0010459]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of proteolysis [GO:0045861]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of stress fiber assembly [GO:0051497]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; positive regulation of cell migration [GO:0030335]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of gene expression [GO:0010628]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of RNA splicing [GO:0033120]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of synapse assembly [GO:0051965]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of stress fiber assembly [GO:0051492]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; response to amino acid [GO:0043200]; response to cAMP [GO:0051591]; response to dexamethasone [GO:0071548]; response to endoplasmic reticulum stress [GO:0034976]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]; response to fructose [GO:0009750]; response to glucocorticoid [GO:0051384]; response to growth factor [GO:0070848]; response to insulin [GO:0032868]; response to iron(II) ion [GO:0010040]; response to nutrient [GO:0007584]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; response to yeast [GO:0001878]; T follicular helper cell differentiation [GO:0061470]	1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; ATPase binding [GO:0051117]; calmodulin binding [GO:0005516]; ErbB-3 class receptor binding [GO:0043125]; insulin binding [GO:0043559]; insulin receptor binding [GO:0005158]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor receptor binding [GO:0005159]; kinase activator activity [GO:0019209]; neurotrophin TRKA receptor binding [GO:0005168]; nuclear estrogen receptor binding [GO:0030331]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; phosphoprotein binding [GO:0051219]; phosphotyrosine residue binding [GO:0001784]; platelet-derived growth factor receptor binding [GO:0005161]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]	cell-cell junction [GO:0005911]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum membrane [GO:1990578]; perinuclear region of cytoplasm [GO:0048471]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IA [GO:0005943]; protein-containing complex [GO:0032991]	GO:0000209; GO:0001678; GO:0001784; GO:0001878; GO:0001934; GO:0001953; GO:0005102; GO:0005158; GO:0005159; GO:0005161; GO:0005168; GO:0005516; GO:0005634; GO:0005737; GO:0005801; GO:0005829; GO:0005911; GO:0005942; GO:0005943; GO:0006006; GO:0006468; GO:0006606; GO:0007162; GO:0007584; GO:0008286; GO:0008625; GO:0008630; GO:0009410; GO:0009750; GO:0010040; GO:0010459; GO:0010592; GO:0010628; GO:0010656; GO:0016020; GO:0016303; GO:0019209; GO:0019221; GO:0019901; GO:0019903; GO:0019904; GO:0022408; GO:0030183; GO:0030331; GO:0030335; GO:0030971; GO:0031625; GO:0032355; GO:0032570; GO:0032760; GO:0032868; GO:0032869; GO:0032991; GO:0033120; GO:0033574; GO:0034143; GO:0034644; GO:0034976; GO:0035014; GO:0035655; GO:0036312; GO:0042267; GO:0042307; GO:0043066; GO:0043125; GO:0043200; GO:0043491; GO:0043559; GO:0043560; GO:0045471; GO:0045663; GO:0045671; GO:0045776; GO:0045861; GO:0045944; GO:0046488; GO:0046854; GO:0046935; GO:0046982; GO:0048009; GO:0048471; GO:0048661; GO:0048662; GO:0050821; GO:0051117; GO:0051219; GO:0051384; GO:0051491; GO:0051492; GO:0051497; GO:0051591; GO:0051965; GO:0060396; GO:0061470; GO:0070542; GO:0070848; GO:0071398; GO:0071548; GO:0120183; GO:1900103; GO:1903076; GO:1990578
GN011569	GN011569.1	Q8R059	65.6	340	341	347	5.02e-173	487	GALE_MOUSE	UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-galactose 4-epimerase)	Mus musculus (Mouse)	galactose catabolic process [GO:0019388]; galactose catabolic process via UDP-galactose, Leloir pathway [GO:0033499]; galactose metabolic process [GO:0006012]; glycolytic process from galactose [GO:0061623]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; UDP-glucose 4-epimerase activity [GO:0003978]; UDP-N-acetylglucosamine 4-epimerase activity [GO:0003974]		GO:0003974; GO:0003978; GO:0006012; GO:0019388; GO:0033499; GO:0042802; GO:0042803; GO:0061623
GN011570	GN011570.1	Q3T1J8	45.7	304	279	306	4.41e-77	239	RTF2_RAT	Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1)	Rattus norvegicus (Rat)	cellular response to hydroxyurea [GO:0072711]; regulation of DNA stability [GO:0097752]	DNA binding [GO:0003677]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0003677; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005730; GO:0072711; GO:0097752
GN011571	GN011571.1	Q5ZML7	33.2	232	246	229	8.28e-30	114	LAP4A_CHICK	Lysosomal-associated transmembrane protein 4A	Gallus gallus (Chicken)	regulation of lysosomal membrane permeability [GO:0097213]		endomembrane system [GO:0012505]; lysosomal membrane [GO:0005765]	GO:0005765; GO:0012505; GO:0097213
GN011573	GN011573.1	A6QLH5	57.0	149	164	337	8.97e-56	181	ERI3_BOVIN	ERI1 exoribonuclease 3 (EC 3.1.-.-) (Prion interactor 1) (Prion protein-interacting protein)	Bos taurus (Bovine)	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; negative regulation of regulatory ncRNA-mediated heterochromatin formation [GO:0060906]	3'-5'-RNA exonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]	cytosol [GO:0005829]	GO:0000175; GO:0000467; GO:0003676; GO:0005829; GO:0060906
GN011574	GN011574.1	Q82WE9	35.7	244	709	385	9.22e-31	128	SELU_NITEU	tRNA 2-selenouridine synthase (EC 2.9.1.3)	Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)	tRNA wobble uridine modification [GO:0002098]	transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765]; tRNA 2-selenouridine synthase activity [GO:0043828]		GO:0002098; GO:0016765; GO:0043828
GN011575	GN011575.1	P25228	84.5	220	219	220	1.07e-133	377	RAB3_DROME	Ras-related protein Rab-3	Drosophila melanogaster (Fruit fly)	cytoskeletal matrix organization at active zone [GO:0048789]; exocytosis [GO:0006887]; maintenance of presynaptic active zone structure [GO:0048790]; neurotransmitter secretion [GO:0007269]; Rab protein signal transduction [GO:0032482]; regulation of neurotransmitter secretion [GO:0046928]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; symbiont entry into host cell [GO:0046718]; vesicle-mediated transport [GO:0016192]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; myosin V binding [GO:0031489]	endosome [GO:0005768]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]	GO:0000287; GO:0003924; GO:0005525; GO:0005768; GO:0005886; GO:0006887; GO:0007269; GO:0008021; GO:0016192; GO:0031489; GO:0031630; GO:0031982; GO:0032482; GO:0045202; GO:0046718; GO:0046928; GO:0048172; GO:0048786; GO:0048789; GO:0048790
GN011577	GN011577.1	Q8BFY9	78.8	886	886	898	0.0	1391	TNPO1_MOUSE	Transportin-1 (Importin beta-2) (Karyopherin beta-2)	Mus musculus (Mouse)	protein import into nucleus [GO:0006606]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005730; GO:0005829; GO:0006606; GO:0008139; GO:0031267; GO:0061608
GN011578	GN011578.1	Q7Z020	40.1	1004	1153	1197	6.75e-202	620	TRPA1_DROME	Transient receptor potential cation channel subfamily A member 1 (dTRPA1) (Ankyrin-like with transmembrane domains protein 1) (dANKTM1)	Drosophila melanogaster (Fruit fly)	calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transport [GO:0006816]; cellular response to heat [GO:0034605]; cellular response to pulsatile fluid shear stress [GO:0097703]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of hot stimulus involved in thermoception [GO:0120168]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; detection of temperature stimulus involved in thermoception [GO:0050960]; mechanosensory behavior [GO:0007638]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; negative phototaxis [GO:0046957]; neuronal signal transduction [GO:0023041]; phototransduction [GO:0007602]; positive regulation of calcium-mediated signaling [GO:0050850]; response to heat [GO:0009408]; response to light stimulus [GO:0009416]; temperature compensation of the circadian clock [GO:0010378]; thermoception [GO:0050955]; thermosensory behavior [GO:0040040]; thermotaxis [GO:0043052]	calcium channel activity [GO:0005262]; intracellularly gated calcium channel activity [GO:0015278]; ligand-gated monoatomic ion channel activity [GO:0015276]; monoatomic cation channel activity [GO:0005261]; temperature-gated cation channel activity [GO:0097604]	cation channel complex [GO:0034703]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001580; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0006816; GO:0007602; GO:0007638; GO:0009408; GO:0009416; GO:0010378; GO:0015276; GO:0015278; GO:0016020; GO:0023041; GO:0034605; GO:0034703; GO:0040040; GO:0043052; GO:0046957; GO:0050850; GO:0050955; GO:0050960; GO:0050965; GO:0050968; GO:0097553; GO:0097604; GO:0097703; GO:0098655; GO:0120168
GN011579	GN011579.1	P62147	93.8	145	170	149	6.53e-60	186	CALM1_BRAFL	Calmodulin-1 (CaM 1)	Branchiostoma floridae (Florida lancelet) (Amphioxus)		calcium ion binding [GO:0005509]		GO:0005509
GN011580	GN011580.1	Q9BLG0	69.2	91	158	148	1.45e-38	131	TNNC_TODPA	Troponin C (TN-C)	Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus)		calcium ion binding [GO:0005509]	myosin II complex [GO:0016460]	GO:0005509; GO:0016460
GN011581	GN011581.1	Q8JI28	51.3	863	935	1007	0.0	951	TLL1_XENLA	Tolloid-like protein 1 (EC 3.4.24.-) (Metalloprotease xolloid-like) (Xenopus tolloid-like protein 1) (Xlr)	Xenopus laevis (African clawed frog)	proteolysis [GO:0006508]	calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0004222; GO:0005509; GO:0005576; GO:0006508; GO:0008270
GN011582	GN011582.1	Q8N0W5	40.6	251	275	287	2.16e-48	165	IQCK_HUMAN	IQ domain-containing protein K	Homo sapiens (Human)				
GN011583	GN011583.1	Q7TN88	25.3	1158	2119	2461	6.49e-86	318	PK1L2_MOUSE	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Mus musculus (Mouse)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]	membrane [GO:0016020]	GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN011584	GN011584.1	P52187	51.5	371	461	427	2.43e-125	374	KCJ12_MOUSE	ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Potassium channel, inwardly rectifying subfamily J member 12)	Mus musculus (Mouse)	potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]	inward rectifier potassium channel activity [GO:0005242]; PDZ domain binding [GO:0030165]	dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]	GO:0005242; GO:0005783; GO:0005886; GO:0006813; GO:0016020; GO:0030165; GO:0030315; GO:0030425; GO:0043025; GO:0051289; GO:1990573
GN011587	GN011587.1	A4QN59	49.6	496	493	498	4.79e-154	451	DPH2_DANRE	2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein histidyl modification to diphthamide [GO:0017183]	2-(3-amino-3-carboxypropyl)histidine synthase activity [GO:0090560]; 4 iron, 4 sulfur cluster binding [GO:0051539]	2-(3-amino-3-carboxypropyl)histidine synthase complex [GO:0120513]	GO:0017183; GO:0051539; GO:0090560; GO:0120513
GN011588	GN011588.1	Q17QK9	54.7	225	259	242	2.01e-83	252	NAA60_BOVIN	N-alpha-acetyltransferase 60 (EC 2.3.1.259) (Histone acetyltransferase type B protein 4) (HAT4) (EC 2.3.1.48) (N-acetyltransferase 15) (N-alpha-acetyltransferase F) (NatF)	Bos taurus (Bovine)	cell population proliferation [GO:0008283]; chromosome segregation [GO:0007059]; N-terminal peptidyl-methionine acetylation [GO:0017196]; N-terminal protein amino acid acetylation [GO:0006474]; nucleosome assembly [GO:0006334]	histone acetyltransferase activity [GO:0004402]; histone H4 acetyltransferase activity [GO:0010485]; protein homodimerization activity [GO:0042803]; protein N-terminal-methionine acetyltransferase activity [GO:0120518]; protein-N-terminal amino-acid acetyltransferase activity [GO:0004596]	Golgi membrane [GO:0000139]	GO:0000139; GO:0004402; GO:0004596; GO:0006334; GO:0006474; GO:0007059; GO:0008283; GO:0010485; GO:0017196; GO:0042803; GO:0120518
GN011589	GN011589.1	Q5HZL1	59.9	242	580	687	1.34e-96	312	ERI2_XENLA	ERI1 exoribonuclease 2 (EC 3.1.-.-) (Exonuclease domain-containing protein 1)	Xenopus laevis (African clawed frog)	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; negative regulation of regulatory ncRNA-mediated heterochromatin formation [GO:0060906]	3'-5'-RNA exonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]		GO:0000175; GO:0000467; GO:0003676; GO:0008270; GO:0060906
GN011590	GN011590.1	Q7TM99	26.0	596	654	508	6.29e-49	182	MOT9_MOUSE	Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9)	Mus musculus (Mouse)	carboxylic acid transmembrane transport [GO:1905039]; carnitine transmembrane transport [GO:1902603]; creatine transmembrane transport [GO:0015881]; urate metabolic process [GO:0046415]	carnitine transmembrane transporter activity [GO:0015226]; creatine transmembrane transporter activity [GO:0005308]; monocarboxylic acid transmembrane transporter activity [GO:0008028]	plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0008028; GO:0015226; GO:0015881; GO:0046415; GO:1902603; GO:1905039
GN011599	GN011599.1	Q7RTX9	25.8	635	688	510	5.01e-48	180	MOT14_HUMAN	Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14)	Homo sapiens (Human)	carboxylic acid transmembrane transport [GO:1905039]	monocarboxylic acid transmembrane transporter activity [GO:0008028]	plasma membrane [GO:0005886]	GO:0005886; GO:0008028; GO:1905039
GN011601	GN011601.1	B4E2M5	39.6	144	152	196	1.96e-31	114	ANR66_HUMAN	Ankyrin repeat domain-containing protein 66	Homo sapiens (Human)				
GN011602	GN011602.1	Q08DV5	41.5	130	212	566	1.06e-09	60.8	RN220_BOVIN	E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220)	Bos taurus (Bovine)	positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of myelination [GO:0031643]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]	GO:0000209; GO:0004842; GO:0005737; GO:0006513; GO:0016567; GO:0031643; GO:0046872; GO:0051865; GO:0060340; GO:0061630; GO:0090263
GN011603	GN011603.1	Q7ZW86	56.5	476	445	470	1.02e-151	442	CWC27_DANRE	Spliceosome-associated protein CWC27 homolog (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein folding [GO:0006457]	peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]	GO:0003755; GO:0005634; GO:0006457; GO:0071005; GO:0071013
GN011605	GN011605.1	Q5VV43	31.8	148	706	1072	7.75e-10	66.2	K0319_HUMAN	Dyslexia-associated protein KIAA0319	Homo sapiens (Human)	negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of dendrite development [GO:2000171]; neuron migration [GO:0001764]; positive regulation of SMAD protein signal transduction [GO:0060391]		clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]	GO:0001764; GO:0005769; GO:0005886; GO:0030517; GO:0030669; GO:0031410; GO:0031901; GO:0048692; GO:0060391; GO:2000171
GN011609	GN011609.1	D3ZGQ5	51.6	440	437	698	6.55e-138	414	NEK8_RAT	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8)	Rattus norvegicus (Rat)	animal organ morphogenesis [GO:0009887]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; regulation of hippo signaling [GO:0035330]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]; cytoplasm [GO:0005737]	GO:0004674; GO:0005524; GO:0005737; GO:0005813; GO:0005929; GO:0005930; GO:0007368; GO:0007507; GO:0009887; GO:0035330; GO:0097543; GO:0097546; GO:0106310
GN011610	GN011610.1	Q9CQ19	84.6	169	170	172	2.87e-96	278	MYL9_MOUSE	Myosin regulatory light polypeptide 9 (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9)	Mus musculus (Mouse)	myofibril assembly [GO:0030239]; stress fiber assembly [GO:0043149]; vascular associated smooth muscle contraction [GO:0014829]	calcium ion binding [GO:0005509]; myosin heavy chain binding [GO:0032036]; structural constituent of cytoskeleton [GO:0005200]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; myofibril [GO:0030016]; myosin II complex [GO:0016460]; stress fiber [GO:0001725]; Z disc [GO:0030018]	GO:0001725; GO:0005200; GO:0005509; GO:0005737; GO:0005938; GO:0014829; GO:0016460; GO:0030016; GO:0030018; GO:0030239; GO:0032036; GO:0043149
GN011611	GN011611.1	Q13946	47.4	449	711	482	5.79e-119	368	PDE7A_HUMAN	High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22) (cAMP-specific phosphodiesterase 7A)	Homo sapiens (Human)	cAMP catabolic process [GO:0006198]; negative regulation of cAMP/PKA signal transduction [GO:0141162]; signal transduction [GO:0007165]	3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004115; GO:0005737; GO:0005829; GO:0006198; GO:0007165; GO:0047555; GO:0141162
GN011612	GN011612.1	P54802	43.4	715	819	743	3.22e-212	620	ANAG_HUMAN	Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form]	Homo sapiens (Human)	heparan sulfate proteoglycan catabolic process [GO:0030200]; heparin proteoglycan metabolic process [GO:0030202]; nervous system development [GO:0007399]	alpha-N-acetylglucosaminidase activity [GO:0004561]; iron ion sequestering activity [GO:0140315]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; vacuole [GO:0005773]	GO:0004561; GO:0005764; GO:0005773; GO:0007399; GO:0030200; GO:0030202; GO:0043202; GO:0070062; GO:0140315
GN011613	GN011613.1	Q8TCU5	31.3	616	1017	1115	1.43e-85	302	NMD3A_HUMAN	Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L)	Homo sapiens (Human)	calcium ion transport [GO:0006816]; hippocampus development [GO:0021766]; ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of dendritic spine maintenance [GO:1902951]; neuron development [GO:0048666]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of synaptic plasticity [GO:0048167]; response to ethanol [GO:0045471]; rhythmic process [GO:0048511]; synaptic transmission, glutamatergic [GO:0035249]	calcium channel activity [GO:0005262]; glutamate receptor activity [GO:0008066]; glycine binding [GO:0016594]; glycine-gated cation channel activity [GO:0160212]; identical protein binding [GO:0042802]; NMDA glutamate receptor activity [GO:0004972]; protein phosphatase 2A binding [GO:0051721]; serine binding [GO:0070905]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neurotransmitter receptor complex [GO:0098878]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]	GO:0004972; GO:0005262; GO:0005789; GO:0005886; GO:0006816; GO:0008066; GO:0014069; GO:0016020; GO:0016594; GO:0017146; GO:0021766; GO:0035235; GO:0035249; GO:0042802; GO:0043005; GO:0043025; GO:0045202; GO:0045211; GO:0045471; GO:0048167; GO:0048511; GO:0048666; GO:0050804; GO:0051721; GO:0061000; GO:0070905; GO:0098655; GO:0098793; GO:0098839; GO:0098878; GO:0098978; GO:0099171; GO:0160212; GO:1902951; GO:1904315
GN011614	GN011614.1	Q8TCU5	28.3	491	1011	1115	1.71e-51	201	NMD3A_HUMAN	Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L)	Homo sapiens (Human)	calcium ion transport [GO:0006816]; hippocampus development [GO:0021766]; ionotropic glutamate receptor signaling pathway [GO:0035235]; modulation of chemical synaptic transmission [GO:0050804]; monoatomic cation transmembrane transport [GO:0098655]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of dendritic spine maintenance [GO:1902951]; neuron development [GO:0048666]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of synaptic plasticity [GO:0048167]; response to ethanol [GO:0045471]; rhythmic process [GO:0048511]; synaptic transmission, glutamatergic [GO:0035249]	calcium channel activity [GO:0005262]; glutamate receptor activity [GO:0008066]; glycine binding [GO:0016594]; glycine-gated cation channel activity [GO:0160212]; identical protein binding [GO:0042802]; NMDA glutamate receptor activity [GO:0004972]; protein phosphatase 2A binding [GO:0051721]; serine binding [GO:0070905]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neurotransmitter receptor complex [GO:0098878]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]	GO:0004972; GO:0005262; GO:0005789; GO:0005886; GO:0006816; GO:0008066; GO:0014069; GO:0016020; GO:0016594; GO:0017146; GO:0021766; GO:0035235; GO:0035249; GO:0042802; GO:0043005; GO:0043025; GO:0045202; GO:0045211; GO:0045471; GO:0048167; GO:0048511; GO:0048666; GO:0050804; GO:0051721; GO:0061000; GO:0070905; GO:0098655; GO:0098793; GO:0098839; GO:0098878; GO:0098978; GO:0099171; GO:0160212; GO:1902951; GO:1904315
GN011623	GN011623.1	O57383	63.6	338	340	334	3.95e-150	428	DPOLB_XENLA	DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18)	Xenopus laevis (African clawed frog)	base-excision repair [GO:0006284]; DNA damage response [GO:0006974]; double-strand break repair via nonhomologous end joining [GO:0006303]	5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; DNA binding [GO:0003677]; DNA polymerase activity [GO:0034061]; DNA-directed DNA polymerase activity [GO:0003887]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003677; GO:0003887; GO:0005634; GO:0005737; GO:0006284; GO:0006303; GO:0006974; GO:0034061; GO:0051575; GO:0140078
GN011625	GN011625.1	Q5E9S4	48.4	473	524	497	3.70e-156	457	AT2L1_BOVIN	Ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) (Alanine--glyoxylate aminotransferase 2-like 1)	Bos taurus (Bovine)		ethanolamine-phosphate phospho-lyase activity [GO:0050459]; pyridoxal phosphate binding [GO:0030170]	mitochondrion [GO:0005739]	GO:0005739; GO:0030170; GO:0050459
GN011626	GN011626.1	Q8BFR2	31.8	110	118	847	4.69e-13	67.4	FSTL5_MOUSE	Follistatin-related protein 5 (Follistatin-like protein 5) (m-D/Bsp120I 1-2)	Mus musculus (Mouse)	cell differentiation [GO:0030154]; regulation of BMP signaling pathway [GO:0030510]	calcium ion binding [GO:0005509]	extracellular region [GO:0005576]	GO:0005509; GO:0005576; GO:0030154; GO:0030510
GN011628	GN011628.1	P27601	54.9	153	175	377	1.12e-50	169	GNA13_MOUSE	Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G protein subunit alpha-13)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; angiogenesis [GO:0001525]; branching involved in blood vessel morphogenesis [GO:0001569]; cell differentiation [GO:0030154]; G protein-coupled receptor signaling pathway [GO:0007186]; in utero embryonic development [GO:0001701]; intracellular signal transduction [GO:0035556]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; platelet activation [GO:0030168]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of phospholipase activity [GO:0010518]; regulation of blood pressure [GO:0008217]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of postsynapse assembly [GO:0150052]; Rho protein signal transduction [GO:0007266]; Rho-activating G protein-coupled receptor signaling pathway [GO:0160221]	D5 dopamine receptor binding [GO:0031752]; G protein activity [GO:0003925]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTPase activity [GO:0003924]; guanyl nucleotide binding [GO:0019001]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; heterotrimeric G-protein complex [GO:0005834]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	GO:0001525; GO:0001569; GO:0001701; GO:0003924; GO:0003925; GO:0005634; GO:0005737; GO:0005829; GO:0005834; GO:0005886; GO:0007186; GO:0007188; GO:0007189; GO:0007204; GO:0007266; GO:0008217; GO:0008360; GO:0009898; GO:0010518; GO:0019001; GO:0030154; GO:0030168; GO:0030334; GO:0031526; GO:0031683; GO:0031752; GO:0035556; GO:0098794; GO:0150052; GO:0160221; GO:1904706; GO:1904753
GN011630	GN011630.1	Q9Y6B7	36.0	506	536	739	3.22e-102	327	AP4B1_HUMAN	AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin)	Homo sapiens (Human)	endocytosis [GO:0006897]; intracellular protein localization [GO:0008104]; intracellular protein transport [GO:0006886]; protein localization to somatodendritic compartment [GO:0061938]; protein targeting [GO:0006605]; vesicle-mediated transport [GO:0016192]	clathrin binding [GO:0030276]	AP-4 adaptor complex [GO:0030124]; clathrin adaptor complex [GO:0030131]; cytoplasmic side of trans-Golgi network transport vesicle membrane [GO:0098541]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]	GO:0005802; GO:0005829; GO:0006605; GO:0006886; GO:0006897; GO:0008104; GO:0016192; GO:0030124; GO:0030131; GO:0030276; GO:0031904; GO:0032588; GO:0061938; GO:0098541
GN011631	GN011631.1	Q9NYH9	40.1	284	309	597	7.44e-61	206	UTP6_HUMAN	U3 small nucleolar RNA-associated protein 6 homolog (Hepatocellular carcinoma-associated antigen 66) (Multiple hat domains protein)	Homo sapiens (Human)	maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]	snoRNA binding [GO:0030515]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]	GO:0000462; GO:0005654; GO:0005694; GO:0005730; GO:0030490; GO:0030515; GO:0032040; GO:0034388; GO:0042274
GN011633	GN011633.1	Q6TFL4	38.2	393	781	600	1.55e-72	251	KLH24_HUMAN	Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1)	Homo sapiens (Human)	intermediate filament organization [GO:0045109]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	adherens junction [GO:0005912]; axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; perikaryon [GO:0043204]	GO:0005737; GO:0005912; GO:0016567; GO:0030057; GO:0030424; GO:0031463; GO:0043161; GO:0043204; GO:0045109; GO:0051865; GO:1990756
GN011635	GN011635.1	P48416	52.9	537	545	545	7.93e-191	548	CP10_LYMST	Cytochrome P450 10 (EC 1.14.-.-) (CYPX)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)		heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]		GO:0004497; GO:0005506; GO:0016705; GO:0020037
GN011636	GN011636.1	P48416	48.5	518	611	545	1.22e-165	486	CP10_LYMST	Cytochrome P450 10 (EC 1.14.-.-) (CYPX)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)		heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]		GO:0004497; GO:0005506; GO:0016705; GO:0020037
GN011637	GN011637.1	P48416	49.4	541	545	545	1.18e-182	527	CP10_LYMST	Cytochrome P450 10 (EC 1.14.-.-) (CYPX)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)		heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]		GO:0004497; GO:0005506; GO:0016705; GO:0020037
GN011638	GN011638.1	P36608	32.4	142	190	191	2.84e-21	89.4	NCS1_CAEEL	Neuronal calcium sensor 1 (NCS-1)	Caenorhabditis elegans	chemosensory behavior [GO:0007635]; chemotaxis [GO:0006935]; regulation of signal transduction [GO:0009966]; response to alkaline pH [GO:0010446]	calcium ion binding [GO:0005509]; calcium sensitive guanylate cyclase activator activity [GO:0008048]	membrane [GO:0016020]; neuronal cell body [GO:0043025]	GO:0005509; GO:0006935; GO:0007635; GO:0008048; GO:0009966; GO:0010446; GO:0016020; GO:0043025
GN011639	GN011639.1	P29104	30.2	172	190	191	4.59e-19	83.6	HPCL4_BOVIN	Hippocalcin-like protein 4 (Neurocalcin-beta)	Bos taurus (Bovine)	regulation of signal transduction [GO:0009966]	calcium ion binding [GO:0005509]		GO:0005509; GO:0009966
GN011640	GN011640.1	P29105	50.8	189	188	193	2.08e-63	197	HPCL1_BOVIN	Hippocalcin-like protein 1 (Neurocalcin-gamma)	Bos taurus (Bovine)	regulation of signal transduction [GO:0009966]	calcium ion binding [GO:0005509]	membrane [GO:0016020]	GO:0005509; GO:0009966; GO:0016020
GN011649	GN011649.1	Q1JQD2	60.0	422	454	446	1.65e-174	499	GRWD1_BOVIN	Glutamate-rich WD repeat-containing protein 1	Bos taurus (Bovine)	DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; ribosome biogenesis [GO:0042254]	chromatin binding [GO:0003682]; DNA replication origin binding [GO:0003688]; histone binding [GO:0042393]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003682; GO:0003688; GO:0005634; GO:0005694; GO:0005730; GO:0006260; GO:0006334; GO:0006337; GO:0042254; GO:0042393
GN011650	GN011650.1	A8WH18	61.3	483	482	476	3.54e-210	592	NARFL_XENTR	Cytosolic Fe-S cluster assembly factor narfl (Nuclear prelamin A recognition factor-like protein)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	iron-sulfur cluster assembly [GO:0016226]		cytosolic [4Fe-4S] assembly targeting complex [GO:0097361]	GO:0016226; GO:0097361
GN011651	GN011651.1	Q9DCJ1	59.2	336	339	326	1.48e-145	416	LST8_MOUSE	Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8)	Mus musculus (Mouse)	cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cytoskeleton organization [GO:0007010]; DNA damage response [GO:0006974]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth [GO:0030307]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of TOR signaling [GO:0032008]; regulation of actin cytoskeleton organization [GO:0032956]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; TORC2 signaling [GO:0038203]	protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; protein-macromolecule adaptor activity [GO:0030674]	cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; serine/threonine protein kinase complex [GO:1902554]; TORC1 complex [GO:0031931]; TORC2 complex [GO:0031932]	GO:0004674; GO:0005737; GO:0005765; GO:0006974; GO:0007010; GO:0010507; GO:0030307; GO:0030674; GO:0030838; GO:0031669; GO:0031929; GO:0031931; GO:0031932; GO:0032008; GO:0032956; GO:0038202; GO:0038203; GO:0043066; GO:0043491; GO:0043539; GO:0045821; GO:0046889; GO:0050731; GO:0051897; GO:0071456; GO:0071470; GO:1902554; GO:1905857
GN011652	GN011652.1	P28662	44.9	136	138	125	4.67e-27	100	BRI3_MOUSE	Membrane protein BRI3 (Brain protein I3)	Mus musculus (Mouse)		identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0005634; GO:0005737; GO:0005765; GO:0042802; GO:0048471
GN011654	GN011654.1	Q9UI43	43.0	93	94	246	1.31e-17	77.4	MRM2_HUMAN	rRNA methyltransferase 2, mitochondrial (EC 2.1.1.-) (16S rRNA (uridine(1369)-2'-O)-methyltransferase) (16S rRNA [Um1369] 2'-O-methyltransferase) (Protein ftsJ homolog 2)	Homo sapiens (Human)	mitochondrial large ribosomal subunit assembly [GO:1902775]; ribosomal large subunit assembly [GO:0000027]; rRNA 2'-O-methylation [GO:0000451]; rRNA methylation [GO:0031167]; rRNA processing [GO:0006364]	rRNA (uridine-2'-O-ribose)-methyltransferase activity [GO:0008650]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	GO:0000027; GO:0000451; GO:0005730; GO:0005739; GO:0005759; GO:0006364; GO:0008650; GO:0031167; GO:1902775
GN011660	GN011660.1	A6QLU8	46.2	78	90	435	7.40e-19	82.4	NXN_BOVIN	Nucleoredoxin (EC 1.8.1.8)	Bos taurus (Bovine)	circulatory system development [GO:0072359]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055]	thioredoxin-disulfide reductase (NADPH) activity [GO:0004791]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004791; GO:0005634; GO:0005829; GO:0016055; GO:0030178; GO:0031397; GO:0072359
GN011663	GN011663.1	Q6AZB8	42.3	168	189	349	2.86e-38	137	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN011664	GN011664.1	Q6AZB8	36.2	149	165	349	2.40e-19	86.3	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN011665	GN011665.1	Q9C6K3	31.4	118	299	603	5.58e-09	60.5	DF1_ARATH	Trihelix transcription factor DF1	Arabidopsis thaliana (Mouse-ear cress)	glucosinolate metabolic process [GO:0019760]; mucilage biosynthetic process involved in seed coat development [GO:0048354]; mucilage pectin biosynthetic process [GO:0048358]; regulation of DNA-templated transcription [GO:0006355]; root hair cell tip growth [GO:0048768]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]	GO:0000976; GO:0000987; GO:0003700; GO:0005634; GO:0006355; GO:0019760; GO:0048354; GO:0048358; GO:0048768
GN011677	GN011677.1	D8VNS6	41.3	63	79	158	3.76e-12	60.8	LECM_CERRY	C-type lectin (CTL)	Cerberus rynchops (Dog-faced water snake)			extracellular region [GO:0005576]	GO:0005576
GN011678	GN011678.1	Q04791	33.6	586	581	557	5.45e-88	286	SASB_ANAPL	Fatty acyl-CoA hydrolase precursor, medium chain (EC 3.1.2.-) (Thioesterase B)	Anas platyrhynchos (Mallard) (Anas boschas)				
GN011679	GN011679.1	Q04791	33.6	586	581	557	1.07e-87	285	SASB_ANAPL	Fatty acyl-CoA hydrolase precursor, medium chain (EC 3.1.2.-) (Thioesterase B)	Anas platyrhynchos (Mallard) (Anas boschas)				
GN011681	GN011681.1	Q9D9S1	41.1	207	229	216	7.21e-34	124	EVG1_MOUSE	UPF0193 protein EVG1 homolog	Mus musculus (Mouse)				
GN011682	GN011682.1	Q9NWM0	32.7	526	499	555	1.86e-75	250	SMOX_HUMAN	Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1)	Homo sapiens (Human)	polyamine biosynthetic process [GO:0006596]; polyamine catabolic process [GO:0006598]; spermine catabolic process [GO:0046208]; xenobiotic metabolic process [GO:0006805]	spermine oxidase activity [GO:0052901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006596; GO:0006598; GO:0006805; GO:0031965; GO:0046208; GO:0052901
GN011683	GN011683.1	Q9NWM0	33.5	532	468	555	5.42e-81	264	SMOX_HUMAN	Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1)	Homo sapiens (Human)	polyamine biosynthetic process [GO:0006596]; polyamine catabolic process [GO:0006598]; spermine catabolic process [GO:0046208]; xenobiotic metabolic process [GO:0006805]	spermine oxidase activity [GO:0052901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006596; GO:0006598; GO:0006805; GO:0031965; GO:0046208; GO:0052901
GN011684	GN011684.1	Q92038	66.0	291	318	327	4.75e-139	399	ACOD_CYPCA	Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase)	Cyprinus carpio (Common carp)	monounsaturated fatty acid biosynthetic process [GO:1903966]; response to fatty acid [GO:0070542]; unsaturated fatty acid biosynthetic process [GO:0006636]	iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; palmitoyl-CoA 9-desaturase activity [GO:0032896]; stearoyl-CoA 9-desaturase activity [GO:0004768]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0004768; GO:0005506; GO:0005789; GO:0006636; GO:0016020; GO:0016491; GO:0032896; GO:0070542; GO:1903966
GN011685	GN011685.1	Q92038	67.0	291	332	327	1.05e-141	406	ACOD_CYPCA	Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase)	Cyprinus carpio (Common carp)	monounsaturated fatty acid biosynthetic process [GO:1903966]; response to fatty acid [GO:0070542]; unsaturated fatty acid biosynthetic process [GO:0006636]	iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; palmitoyl-CoA 9-desaturase activity [GO:0032896]; stearoyl-CoA 9-desaturase activity [GO:0004768]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0004768; GO:0005506; GO:0005789; GO:0006636; GO:0016020; GO:0016491; GO:0032896; GO:0070542; GO:1903966
GN011686	GN011686.1	Q13257	70.5	139	149	205	5.25e-61	189	MD2L1_HUMAN	Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1)	Homo sapiens (Human)	mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; mitotic spindle [GO:0072686]; mitotic spindle assembly checkpoint MAD1-MAD2 complex [GO:1990728]; nuclear pore nuclear basket [GO:0044615]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922]	GO:0000776; GO:0000922; GO:0005634; GO:0005737; GO:0005829; GO:0007094; GO:0033597; GO:0042177; GO:0042802; GO:0042803; GO:0044615; GO:0045930; GO:0048471; GO:0072686; GO:0090267; GO:1904667; GO:1990728
GN011687	GN011687.1	Q8AW52	48.7	76	196	134	3.22e-11	61.6	ATOH7_DANRE	Transcription factor atoh7 (Atonal bHLH transcription factor 7) (Helix-loop-helix protein zATH-5) (zATH5) (Protein atonal homolog 5) (Protein atonal homolog 7) (Protein lakritz)	Danio rerio (Zebrafish) (Brachydanio rerio)	axon development [GO:0061564]; camera-type eye development [GO:0043010]; cell fate commitment [GO:0045165]; eye development [GO:0001654]; neural retina development [GO:0003407]; neuron fate commitment [GO:0048663]; pigmentation [GO:0043473]; positive regulation of neurogenesis [GO:0050769]; positive regulation of retinal ganglion cell axon guidance [GO:1902336]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; retina layer formation [GO:0010842]; sensory organ development [GO:0007423]; swimming behavior [GO:0036269]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; transcription cis-regulatory region binding [GO:0000976]	axon [GO:0030424]; nucleus [GO:0005634]; perikaryon [GO:0043204]	GO:0000976; GO:0000981; GO:0001654; GO:0003407; GO:0005634; GO:0006357; GO:0007346; GO:0007423; GO:0010842; GO:0030424; GO:0036269; GO:0043010; GO:0043204; GO:0043473; GO:0045165; GO:0045944; GO:0046983; GO:0048663; GO:0050769; GO:0051726; GO:0060041; GO:0061564; GO:0070888; GO:1902336
GN011688	GN011688.1	Q92886	65.4	78	298	237	1.66e-20	91.3	NGN1_HUMAN	Neurogenin-1 (NGN-1) (Class A basic helix-loop-helix protein 6) (bHLHa6) (Neurogenic basic-helix-loop-helix protein) (Neurogenic differentiation factor 3) (NeuroD3)	Homo sapiens (Human)	auditory behavior [GO:0031223]; axon development [GO:0061564]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; craniofacial suture morphogenesis [GO:0097094]; forebrain development [GO:0030900]; genitalia development [GO:0048806]; genitalia morphogenesis [GO:0035112]; hard palate morphogenesis [GO:1905748]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; learned vocalization behavior [GO:0098583]; mastication [GO:0071626]; negative regulation of relaxation of muscle [GO:1901078]; negative regulation of saliva secretion [GO:1905747]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; peristalsis [GO:0030432]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of muscle organ development [GO:0048634]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory organ development [GO:0007423]; thorax and anterior abdomen determination [GO:0007356]; trigeminal nerve development [GO:0021559]; vestibulocochlear nerve formation [GO:0021650]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein homodimerization activity [GO:0042803]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]; perikaryon [GO:0043204]	GO:0000785; GO:0000981; GO:0003677; GO:0003682; GO:0003700; GO:0005634; GO:0006357; GO:0007356; GO:0007399; GO:0007423; GO:0021559; GO:0021650; GO:0030432; GO:0030900; GO:0031223; GO:0035112; GO:0042472; GO:0042803; GO:0043204; GO:0045666; GO:0045944; GO:0048634; GO:0048806; GO:0048839; GO:0050885; GO:0061564; GO:0070888; GO:0071626; GO:0090102; GO:0090103; GO:0097094; GO:0098583; GO:1901078; GO:1905747; GO:1905748; GO:1990837
GN011693	GN011693.1	P22274	63.0	181	189	179	1.66e-76	229	ARF_CANAL	ADP-ribosylation factor	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)	cellular response to reactive oxygen species [GO:0034614]; intracellular protein transport [GO:0006886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	GO:0003924; GO:0005525; GO:0005794; GO:0005886; GO:0006886; GO:0034614
GN011694	GN011694.1	P91924	62.6	163	166	183	9.46e-71	214	ARF_DUGJA	ADP-ribosylation factor	Dugesia japonica (Planarian)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi apparatus [GO:0005794]	GO:0003924; GO:0005525; GO:0005794
GN011695	GN011695.1	P51824	59.1	186	189	197	2.70e-72	219	ARF1_SOLTU	ADP-ribosylation factor 1 (EC 3.6.5.2)	Solanum tuberosum (Potato)	intracellular protein transport [GO:0006886]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phospholipase activator activity [GO:0016004]	Golgi apparatus [GO:0005794]	GO:0003924; GO:0003925; GO:0005525; GO:0005794; GO:0006886; GO:0016004
GN011696	GN011696.1	P91924	60.1	178	189	183	5.15e-74	223	ARF_DUGJA	ADP-ribosylation factor	Dugesia japonica (Planarian)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi apparatus [GO:0005794]	GO:0003924; GO:0005525; GO:0005794
GN011697	GN011697.1	P51824	58.4	185	189	197	1.64e-73	223	ARF1_SOLTU	ADP-ribosylation factor 1 (EC 3.6.5.2)	Solanum tuberosum (Potato)	intracellular protein transport [GO:0006886]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phospholipase activator activity [GO:0016004]	Golgi apparatus [GO:0005794]	GO:0003924; GO:0003925; GO:0005525; GO:0005794; GO:0006886; GO:0016004
GN011702	GN011702.1	P28575	33.8	346	583	584	9.79e-71	241	IPP_MOUSE	Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Murine IAP-promoted placenta-expressed protein) (Protein MIPP)	Mus musculus (Mouse)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	actin binding [GO:0003779]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	GO:0003779; GO:0005737; GO:0005856; GO:0016567; GO:0031463; GO:0043161; GO:1990756
GN011705	GN011705.1	Q6P2X9	37.6	226	374	473	2.40e-43	159	MOT12_XENTR	Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0046449
GN011706	GN011706.1	Q28C34	68.4	79	91	509	4.78e-34	124	AN13C_XENTR	Ankyrin repeat domain-containing protein 13C	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	protein targeting to membrane [GO:0006612]	protein carrier activity [GO:0140597]; signaling receptor binding [GO:0005102]	endoplasmic reticulum membrane [GO:0005789]	GO:0005102; GO:0005789; GO:0006612; GO:0140597
GN011709	GN011709.1	P18433	38.8	286	353	802	2.00e-59	207	PTPRA_HUMAN	Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)	Homo sapiens (Human)	integrin-mediated signaling pathway [GO:0007229]; regulation of focal adhesion assembly [GO:0051893]; signal transduction [GO:0007165]	protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004725; GO:0005001; GO:0005886; GO:0005925; GO:0007165; GO:0007229; GO:0016020; GO:0043235; GO:0051893; GO:0070062
GN011710	GN011710.1	P18433	38.8	286	353	802	2.00e-59	207	PTPRA_HUMAN	Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)	Homo sapiens (Human)	integrin-mediated signaling pathway [GO:0007229]; regulation of focal adhesion assembly [GO:0051893]; signal transduction [GO:0007165]	protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004725; GO:0005001; GO:0005886; GO:0005925; GO:0007165; GO:0007229; GO:0016020; GO:0043235; GO:0051893; GO:0070062
GN011713	GN011713.1	Q9UHM6	31.4	204	216	478	1.26e-26	109	OPN4_HUMAN	Melanopsin (Opsin-4)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to light stimulus [GO:0071482]; entrainment of circadian clock by photoperiod [GO:0043153]; G protein-coupled receptor signaling pathway [GO:0007186]; hyaloid vascular plexus regression [GO:1990384]; optokinetic behavior [GO:0007634]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phototransduction [GO:0007602]; regulation of circadian rhythm [GO:0042752]; visual perception [GO:0007601]	11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]	axon [GO:0030424]; dendrite [GO:0030425]; membrane [GO:0016020]; perikaryon [GO:0043204]; photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; sperm head plasma membrane [GO:1990913]	GO:0004930; GO:0005502; GO:0005886; GO:0007186; GO:0007189; GO:0007193; GO:0007200; GO:0007601; GO:0007602; GO:0007634; GO:0008020; GO:0016020; GO:0030424; GO:0030425; GO:0042752; GO:0043153; GO:0043204; GO:0071482; GO:0097381; GO:1990384; GO:1990913
GN011715	GN011715.1	Q8N122	59.4	1319	1272	1335	0.0	1510	RPTOR_HUMAN	Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)	Homo sapiens (Human)	cellular response to amino acid stimulus [GO:0071230]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to L-leucine [GO:0071233]; cellular response to nutrient levels [GO:0031669]; cellular response to osmotic stress [GO:0071470]; cellular response to starvation [GO:0009267]; DNA damage response [GO:0006974]; negative regulation of autophagy [GO:0010507]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of glycolytic process [GO:0045821]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of pentose-phosphate shunt [GO:1905857]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]	14-3-3 protein binding [GO:0071889]; enzyme-substrate adaptor activity [GO:0140767]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; TORC1 complex [GO:0031931]	GO:0001558; GO:0001938; GO:0005654; GO:0005737; GO:0005764; GO:0005765; GO:0005829; GO:0006974; GO:0008361; GO:0009267; GO:0009410; GO:0010494; GO:0010507; GO:0019901; GO:0030291; GO:0030295; GO:0030307; GO:0030425; GO:0030674; GO:0031267; GO:0031669; GO:0031929; GO:0031931; GO:0032008; GO:0035176; GO:0038202; GO:0043025; GO:0044877; GO:0045672; GO:0045821; GO:0045945; GO:0046889; GO:0071230; GO:0071233; GO:0071333; GO:0071456; GO:0071470; GO:0071889; GO:0140767; GO:1900087; GO:1901331; GO:1905857
GN011716	GN011716.1	O62640	46.9	64	454	358	1.02e-10	66.6	PIAP_PIG	Putative inhibitor of apoptosis	Sus scrofa (Pig)	negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; regulation of cell cycle [GO:0051726]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0031398; GO:0033209; GO:0043027; GO:0043066; GO:0043123; GO:0051726; GO:0060546; GO:0061630
GN011718	GN011718.1	Q7T3S5	30.1	286	330	379	3.89e-26	110	B3G5A_DANRE	Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A (EC 2.4.1.206) (Lactotriaosylceramide synthase A) (Lc(3)Cer synthase A) (Lc3 synthase A) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5A) (BGnT-5A) (Beta-1,3-Gn-T5A) (Beta-1,3-N-acetylglucosaminyltransferase 5A) (Beta3Gn-T5A)	Danio rerio (Zebrafish) (Brachydanio rerio)	glycoprotein biosynthetic process [GO:0009101]; sphingolipid biosynthetic process [GO:0030148]	lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity [GO:0047256]	Golgi membrane [GO:0000139]	GO:0000139; GO:0009101; GO:0030148; GO:0047256
GN011725	GN011725.1	Q9DCM4	71.4	105	105	105	4.44e-55	169	DNAL4_MOUSE	Dynein axonemal light chain 4	Mus musculus (Mouse)	microtubule-based process [GO:0007017]	identical protein binding [GO:0042802]	axoneme [GO:0005930]; dynein complex [GO:0030286]	GO:0005930; GO:0007017; GO:0030286; GO:0042802
GN011726	GN011726.1	Q9Z2X3	51.7	60	224	231	4.11e-12	66.6	PSD10_RAT	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin)	Rattus norvegicus (Rat)	negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; proteasome regulatory particle assembly [GO:0070682]; regulation of transcription by RNA polymerase II [GO:0006357]	RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]	GO:0000122; GO:0000502; GO:0005634; GO:0005737; GO:0005829; GO:0006357; GO:0008540; GO:0030307; GO:0031398; GO:0032436; GO:0043066; GO:0043409; GO:0043518; GO:0045737; GO:0061629; GO:0070682; GO:0090201
GN011729	GN011729.1	P0C7U4	26.6	308	357	361	1.11e-14	77.8	C3AR_DANRE	C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R)	Danio rerio (Zebrafish) (Brachydanio rerio)	complement receptor mediated signaling pathway [GO:0002430]; inflammatory response [GO:0006954]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	complement component C5a receptor activity [GO:0004878]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]	GO:0002430; GO:0004878; GO:0004930; GO:0005886; GO:0006954; GO:0007200; GO:0007204
GN011730	GN011730.1	O94778	42.5	226	255	261	3.16e-48	163	AQP8_HUMAN	Aquaporin-8 (AQP-8)	Homo sapiens (Human)	ammonium import across plasma membrane [GO:0140157]; ammonium transmembrane transport [GO:0072488]; B cell differentiation [GO:0030183]; cellular detoxification [GO:1990748]; cellular response to cAMP [GO:0071320]; hydrogen peroxide transmembrane transport [GO:0080170]; methylammonium transport [GO:0015843]; regulation of cholesterol biosynthetic process [GO:0045540]; transepithelial water transport [GO:0035377]; urea transport [GO:0015840]; water transport [GO:0006833]	ammonium channel activity [GO:0008519]; methylammonium channel activity [GO:0015264]; urea channel activity [GO:0015265]; water channel activity [GO:0015250]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; intracellular canaliculus [GO:0046691]; intracellular vesicle [GO:0097708]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; smooth endoplasmic reticulum membrane [GO:0030868]	GO:0005739; GO:0005743; GO:0005790; GO:0005886; GO:0006833; GO:0008519; GO:0015250; GO:0015264; GO:0015265; GO:0015840; GO:0015843; GO:0016323; GO:0016324; GO:0030183; GO:0030868; GO:0031526; GO:0031966; GO:0035377; GO:0045177; GO:0045540; GO:0046691; GO:0071320; GO:0072488; GO:0080170; GO:0097708; GO:0140157; GO:1990748
GN011733	GN011733.1	Q95JD5	37.6	279	617	296	1.26e-45	166	ST1B1_CANLF	Sulfotransferase 1B1 (ST1B1) (cSULT1B1) (EC 2.8.2.1) (Sulfotransferase family cytosolic 1B member 1)	Canis lupus familiaris (Dog) (Canis familiaris)	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	aryl sulfotransferase activity [GO:0004062]	cytoplasm [GO:0005737]	GO:0004062; GO:0005737; GO:0006068; GO:0006805; GO:0009812; GO:0030855; GO:0042403; GO:0050427; GO:0051923
GN011734	GN011734.1	A0A2B4RNI3	34.0	206	370	688	4.59e-26	113	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN011742	GN011742.1	E1BD59	23.3	722	651	732	1.12e-39	159	TRI56_BOVIN	E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (Tripartite motif-containing protein 56)	Bos taurus (Bovine)	defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; response to type I interferon [GO:0034340]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0006513; GO:0008270; GO:0032728; GO:0034340; GO:0045087; GO:0051607; GO:0060340; GO:0061630; GO:0070534
GN011744	GN011744.1	P47809	73.7	319	395	397	2.42e-166	474	MP2K4_MOUSE	Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1)	Mus musculus (Mouse)	cell growth involved in cardiac muscle cell development [GO:0061049]; cellular response to mechanical stimulus [GO:0071260]; ERBB signaling pathway [GO:0038127]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of motor neuron apoptotic process [GO:2000672]; neuromuscular junction development [GO:0007528]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA replication [GO:0045740]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein phosphorylation [GO:0001934]; protein phosphorylation [GO:0006468]; response to wounding [GO:0009611]; smooth muscle cell apoptotic process [GO:0034390]	ATP binding [GO:0005524]; JUN kinase kinase activity [GO:0008545]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase binding [GO:0051019]; mitogen-activated protein kinase p38 binding [GO:0048273]; molecular adaptor activity [GO:0060090]; protein serine kinase activity [GO:0106310]; protein tyrosine kinase activity [GO:0004713]	axon [GO:0030424]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; nucleus [GO:0005634]; perikaryon [GO:0043204]	GO:0000165; GO:0001934; GO:0004708; GO:0004713; GO:0005524; GO:0005634; GO:0005829; GO:0006468; GO:0007254; GO:0007528; GO:0008545; GO:0009611; GO:0030424; GO:0032839; GO:0034390; GO:0036481; GO:0038127; GO:0043065; GO:0043204; GO:0043525; GO:0045740; GO:0046330; GO:0048273; GO:0051019; GO:0060090; GO:0061049; GO:0071260; GO:0106310; GO:2000672
GN011745	GN011745.1	Q96S21	73.4	192	195	281	1.56e-101	297	RB40C_HUMAN	Ras-related protein Rab-40C (EC 3.6.5.2) (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3)	Homo sapiens (Human)	cell migration [GO:0016477]; exocytosis [GO:0006887]; intracellular signal transduction [GO:0035556]; lipid droplet formation [GO:0140042]; negative regulation of focal adhesion assembly [GO:0051895]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; lipid droplet [GO:0005811]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GO:0000139; GO:0003924; GO:0003925; GO:0005525; GO:0005768; GO:0005811; GO:0005829; GO:0005886; GO:0006887; GO:0008021; GO:0016477; GO:0016567; GO:0031466; GO:0035556; GO:0043161; GO:0051895; GO:0140042; GO:1990756
GN011747	GN011747.1	Q5ZL26	67.6	352	357	369	1.34e-163	464	KPRB_CHICK	Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2)	Gallus gallus (Chicken)	5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; purine nucleotide biosynthetic process [GO:0006164]	enzyme regulator activity [GO:0030234]; magnesium ion binding [GO:0000287]	cytoplasm [GO:0005737]	GO:0000287; GO:0005737; GO:0006015; GO:0006164; GO:0030234
GN011748	GN011748.1	A7M7B9	64.1	248	311	281	3.25e-112	329	NTH_CHICK	Endonuclease III-like protein 1 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)	Gallus gallus (Chicken)	base-excision repair, AP site formation [GO:0006285]; nucleotide-excision repair [GO:0006289]	class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; DNA binding [GO:0003677]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]	mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0000703; GO:0003677; GO:0005634; GO:0005739; GO:0006285; GO:0006289; GO:0140078
GN011749	GN011749.1	O42587	82.7	422	428	423	6.40e-245	676	PR6AA_XENLA	26S proteasome regulatory subunit 6A-A (26S proteasome AAA-ATPase subunit RPT5-A) (Proteasome 26S subunit ATPase 3-A) (Tat-binding protein 6) (TBP-6)	Xenopus laevis (African clawed frog)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]	GO:0005524; GO:0005634; GO:0005737; GO:0016887; GO:0022624; GO:0036402
GN011751	GN011751.1	Q503M4	28.1	402	398	477	3.08e-32	130	MT12B_DANRE	Monocarboxylate transporter 12-B (MCT 12-B) (Solute carrier family 16 member 12-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; transmembrane transporter activity [GO:0022857]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0022857; GO:0046449
GN011754	GN011754.1	O14511	28.7	209	512	850	6.78e-19	94.0	NRG2_HUMAN	Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)]	Homo sapiens (Human)	animal organ development [GO:0048513]; ERBB4 signaling pathway [GO:0038130]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; signal transduction [GO:0007165]	signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0005102; GO:0005576; GO:0005654; GO:0005730; GO:0005886; GO:0007165; GO:0007399; GO:0035556; GO:0038130; GO:0048513
GN011756	GN011756.1	A7SE07	66.4	253	273	270	6.16e-131	374	NUBP2_NEMVE	Cytosolic Fe-S cluster assembly factor NUBP2 homolog	Nematostella vectensis (Starlet sea anemone)	iron-sulfur cluster assembly [GO:0016226]	4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005524; GO:0005634; GO:0005737; GO:0016226; GO:0051539; GO:0140663
GN011757	GN011757.1	O95477	58.7	126	153	2261	6.77e-41	148	ABCA1_HUMAN	Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cholesterol [GO:0071397]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to retinoic acid [GO:0071300]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; endosomal transport [GO:0016197]; export across plasma membrane [GO:0140115]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lysosome organization [GO:0007040]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; platelet dense granule organization [GO:0060155]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of high-density lipoprotein particle assembly [GO:0090107]; response to laminar fluid shear stress [GO:0034616]; response to vitamin B3 [GO:0033552]; reverse cholesterol transport [GO:0043691]; signal release [GO:0023061]	ABC-type transporter activity [GO:0140359]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein A-I receptor activity [GO:0034188]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; high-density lipoprotein particle binding [GO:0008035]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transfer activity [GO:0120014]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; sphingolipid floppase activity [GO:0046623]; syntaxin binding [GO:0019905]; transmembrane protein transporter activity [GO:0008320]	basolateral plasma membrane [GO:0016323]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	GO:0005102; GO:0005524; GO:0005768; GO:0005789; GO:0005794; GO:0005886; GO:0007040; GO:0007186; GO:0007189; GO:0008035; GO:0008203; GO:0008320; GO:0009306; GO:0009897; GO:0010745; GO:0010875; GO:0010887; GO:0015485; GO:0016197; GO:0016323; GO:0016887; GO:0019905; GO:0023061; GO:0030139; GO:0031210; GO:0031267; GO:0032367; GO:0032489; GO:0033344; GO:0033552; GO:0033700; GO:0034185; GO:0034186; GO:0034188; GO:0034380; GO:0034616; GO:0042158; GO:0042626; GO:0042632; GO:0043691; GO:0045121; GO:0045332; GO:0045335; GO:0046623; GO:0048471; GO:0051117; GO:0055091; GO:0060155; GO:0071222; GO:0071300; GO:0071345; GO:0071397; GO:0071404; GO:0071466; GO:0071806; GO:0090107; GO:0090108; GO:0090554; GO:0090556; GO:0097708; GO:0120014; GO:0120020; GO:0140115; GO:0140326; GO:0140328; GO:0140359
GN011758	GN011758.1	Q8R420	54.0	226	260	1704	2.45e-68	232	ABCA3_MOUSE	Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form]	Mus musculus (Mouse)	lung development [GO:0030324]; organelle assembly [GO:0070925]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid homeostasis [GO:0055091]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of protein homooligomerization [GO:0032464]; positive regulation of vesicle fusion [GO:0031340]; regulation of lipid biosynthetic process [GO:0046890]; regulation of lipid transport [GO:0032368]; regulation of phosphatidylcholine metabolic process [GO:0150172]; response to glucocorticoid [GO:0051384]; surfactant homeostasis [GO:0043129]; xenobiotic export from cell [GO:0046618]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine transfer activity [GO:0120019]	alveolar lamellar body [GO:0097208]; alveolar lamellar body membrane [GO:0097233]; cytoplasmic vesicle membrane [GO:0030659]; lamellar body [GO:0042599]; lamellar body membrane [GO:0097232]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]	GO:0005524; GO:0005765; GO:0005770; GO:0005886; GO:0006855; GO:0008559; GO:0010875; GO:0015914; GO:0016887; GO:0030324; GO:0030659; GO:0031340; GO:0031902; GO:0032368; GO:0032464; GO:0032585; GO:0042599; GO:0042626; GO:0042908; GO:0043129; GO:0046470; GO:0046471; GO:0046618; GO:0046890; GO:0051384; GO:0055091; GO:0070925; GO:0097208; GO:0097232; GO:0097233; GO:0120019; GO:0140326; GO:0140345; GO:0150172; GO:1902995; GO:2001140
GN011761	GN011761.1	Q99758	42.8	1758	1904	1704	0.0	1318	ABCA3_HUMAN	Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ABC-C transporter) (ATP-binding cassette sub-family A member 3) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form]	Homo sapiens (Human)	lipid transport [GO:0006869]; lung development [GO:0030324]; organelle assembly [GO:0070925]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid homeostasis [GO:0055091]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of protein homooligomerization [GO:0032464]; positive regulation of vesicle fusion [GO:0031340]; regulation of lipid biosynthetic process [GO:0046890]; regulation of phosphatidylcholine metabolic process [GO:0150172]; response to glucocorticoid [GO:0051384]; response to xenobiotic stimulus [GO:0009410]; surfactant homeostasis [GO:0043129]; xenobiotic export from cell [GO:0046618]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid carrier activity [GO:0005319]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine transfer activity [GO:0120019]	alveolar lamellar body [GO:0097208]; alveolar lamellar body membrane [GO:0097233]; cytoplasmic vesicle membrane [GO:0030659]; extracellular region [GO:0005576]; lamellar body [GO:0042599]; lamellar body membrane [GO:0097232]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]	GO:0005319; GO:0005524; GO:0005576; GO:0005765; GO:0005770; GO:0005886; GO:0006855; GO:0006869; GO:0008559; GO:0009410; GO:0010875; GO:0015914; GO:0016887; GO:0030324; GO:0030659; GO:0031340; GO:0031902; GO:0032464; GO:0032585; GO:0042599; GO:0042626; GO:0042908; GO:0043129; GO:0046470; GO:0046471; GO:0046618; GO:0046890; GO:0051384; GO:0055091; GO:0070925; GO:0097208; GO:0097232; GO:0097233; GO:0120019; GO:0140326; GO:0140345; GO:0150172; GO:1902995; GO:2001140
GN011762	GN011762.1	Q5M9B1	53.9	243	337	360	1.19e-97	296	SPSB3_XENLA	SPRY domain-containing SOCS box protein 3 (SSB-3)	Xenopus laevis (African clawed frog)	negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005634; GO:0010719; GO:0019005; GO:0031466; GO:0043161; GO:0070936; GO:0160049; GO:1990756
GN011763	GN011763.1	P15880	89.4	226	283	293	2.51e-145	412	RS2_HUMAN	Small ribosomal subunit protein uS5 (40S ribosomal protein S2) (40S ribosomal protein S4) (Protein LLRep3)	Homo sapiens (Human)	cytoplasmic translation [GO:0002181]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; translation [GO:0006412]	cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0002181; GO:0003723; GO:0003729; GO:0003735; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005925; GO:0006412; GO:0016020; GO:0017134; GO:0019899; GO:0022626; GO:0022627; GO:0045296; GO:0051443; GO:0070062
GN011764	GN011764.1	P53470	88.1	377	377	376	1.76e-254	696	ACT1_SCHMA	Actin-1 (EC 3.6.4.-)	Schistosoma mansoni (Blood fluke)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN011766	GN011766.1	Q93129	92.5	375	375	375	1.60e-263	718	ACTC_BRABE	Actin, cytoplasmic (EC 3.6.4.-) (BbCA1) [Cleaved into: Actin, cytoplasmic, N-terminally processed]	Branchiostoma belcheri (Amphioxus)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN011767	GN011767.1	P55884	64.0	681	701	814	0.0	918	EIF3B_HUMAN	Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116)	Homo sapiens (Human)	formation of cytoplasmic translation initiation complex [GO:0001732]; IRES-dependent viral translational initiation [GO:0075522]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525]	molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; synapse [GO:0045202]	GO:0001732; GO:0003723; GO:0003743; GO:0005829; GO:0005852; GO:0006413; GO:0006446; GO:0010494; GO:0016282; GO:0031369; GO:0033290; GO:0045202; GO:0060090; GO:0070062; GO:0071541; GO:0075522; GO:0075525
GN011768	GN011768.1	Q7ZT82	47.3	262	390	382	2.11e-45	163	RFX1L_DANRE	RNA binding protein fox-1 homolog 1-like (Ataxin 2-binding protein 1-like) (Fox-1 homolog-like protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cardiac muscle cell development [GO:0055013]; heart process [GO:0003015]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; skeletal muscle fiber development [GO:0048741]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000381; GO:0003015; GO:0003723; GO:0003729; GO:0005634; GO:0005737; GO:0007399; GO:0008380; GO:0043484; GO:0048741; GO:0055013
GN011770	GN011770.1	Q5PPZ9	35.6	610	647	607	2.07e-114	358	GDS1B_XENLA	Rap1 GTPase-GDP dissociation stimulator 1-B (Rap1gds1-B protein) (RalB-binding protein B) (XsmgGDS-B) (smgGDS-B)	Xenopus laevis (African clawed frog)	positive regulation of GTPase activity [GO:0043547]; small GTPase-mediated signal transduction [GO:0007264]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]	GO:0005085; GO:0005739; GO:0005783; GO:0005829; GO:0007264; GO:0031267; GO:0043547
GN011771	GN011771.1	Q62417	35.3	425	2101	1290	1.63e-48	194	SRBS1_MOUSE	Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)	Mus musculus (Mouse)	acetylcholine receptor signaling pathway [GO:0095500]; cell-substrate adhesion [GO:0031589]; cellular response to insulin stimulus [GO:0032869]; cytoskeleton organization [GO:0007010]; focal adhesion assembly [GO:0048041]; insulin receptor signaling pathway [GO:0008286]; positive regulation of D-glucose import across plasma membrane [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904393]; stress fiber assembly [GO:0043149]	insulin receptor binding [GO:0005158]; protein kinase binding [GO:0019901]; signaling receptor complex adaptor activity [GO:0030159]; ubiquitin protein ligase binding [GO:0031625]	adherens junction [GO:0005912]; cell-substrate junction [GO:0030055]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; synapse [GO:0045202]	GO:0001725; GO:0005158; GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0005856; GO:0005886; GO:0005912; GO:0005925; GO:0007010; GO:0008286; GO:0016020; GO:0016363; GO:0016600; GO:0019901; GO:0030055; GO:0030159; GO:0031589; GO:0031625; GO:0032869; GO:0043149; GO:0045121; GO:0045202; GO:0045725; GO:0046326; GO:0046628; GO:0046889; GO:0048041; GO:0095500; GO:1903078; GO:1904393
GN011772	GN011772.1	Q91YE8	46.0	87	827	1087	2.37e-14	81.3	SYNP2_MOUSE	Synaptopodin-2 (Myopodin)	Mus musculus (Mouse)	autophagosome assembly [GO:0000045]; chaperone-mediated autophagy [GO:0061684]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cell migration [GO:0030335]; regulation of Rho protein signal transduction [GO:0035023]	14-3-3 protein binding [GO:0071889]; actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; filamin binding [GO:0031005]; muscle alpha-actinin binding [GO:0051371]; protein-macromolecule adaptor activity [GO:0030674]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; stress fiber [GO:0001725]; vesicle tethering complex [GO:0099023]; Z disc [GO:0030018]	GO:0000045; GO:0001725; GO:0003779; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005925; GO:0015629; GO:0030018; GO:0030335; GO:0030674; GO:0031005; GO:0032233; GO:0035023; GO:0051371; GO:0051393; GO:0061684; GO:0071889; GO:0099023
GN011778	GN011778.1	Q8IVF7	24.1	755	1018	1028	4.37e-41	167	FMNL3_HUMAN	Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; cell migration [GO:0016477]; cortical actin cytoskeleton organization [GO:0030866]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]	actin filament binding [GO:0051015]; GTPase activating protein binding [GO:0032794]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0005737; GO:0005829; GO:0005886; GO:0008360; GO:0016477; GO:0030036; GO:0030866; GO:0031267; GO:0032794; GO:0046847; GO:0051015
GN011779	GN011779.1	P02711	25.8	295	370	461	3.30e-30	123	ACHA_TORMA	Acetylcholine receptor subunit alpha	Torpedo marmorata (Marbled electric ray)		acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0004888; GO:0005886; GO:0022848; GO:0045211
GN011787	GN011787.1	Q66IC8	38.4	138	215	173	5.21e-25	99.4	DYLT5_DANRE	Dynein light chain Tctex-type 5 (Tctex1 domain-containing protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505; GO:0060271
GN011788	GN011788.1	B2RX14	37.8	1075	1473	1644	1.13e-205	652	TUT4_MOUSE	Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11)	Mus musculus (Mouse)	interleukin-6-mediated signaling pathway [GO:0070102]; miRNA catabolic process [GO:0010587]; miRNA metabolic process [GO:0010586]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; oocyte maturation [GO:0001556]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; positive regulation of interleukin-6 production [GO:0032755]; pre-miRNA processing [GO:0031054]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; RNA 3'-end processing [GO:0031123]; stem cell population maintenance [GO:0019827]; transposable element silencing by mRNA destabilization [GO:0141008]	miRNA binding [GO:0035198]; RNA uridylyltransferase activity [GO:0050265]; uridylyltransferase activity [GO:0070569]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0001556; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0008270; GO:0010586; GO:0010587; GO:0019827; GO:0031054; GO:0031123; GO:0031664; GO:0032755; GO:0035198; GO:0036464; GO:0043124; GO:0050265; GO:0070102; GO:0070569; GO:0141008; GO:1990074
GN011789	GN011789.1	Q7TT28	47.0	455	1139	1213	3.77e-126	419	REXO1_MOUSE	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1)	Mus musculus (Mouse)	rRNA 3'-end processing [GO:0031125]	exonuclease activity [GO:0004527]; nucleic acid binding [GO:0003676]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	GO:0003676; GO:0004527; GO:0005654; GO:0016604; GO:0031125
GN011790	GN011790.1	Q5TM68	36.3	251	1729	2173	8.04e-38	160	MDC1_MACMU	Mediator of DNA damage checkpoint protein 1	Macaca mulatta (Rhesus macaque)	DNA replication checkpoint signaling [GO:0000076]; protein localization to site of double-strand break [GO:1990166]	chromatin-protein adaptor activity [GO:0140463]; histone reader activity [GO:0140566]	chromosome [GO:0005694]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000076; GO:0005634; GO:0005694; GO:0035861; GO:0140463; GO:0140566; GO:1990166
GN011795	GN011795.1	E1BD59	26.5	366	1030	732	1.71e-24	114	TRI56_BOVIN	E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (Tripartite motif-containing protein 56)	Bos taurus (Bovine)	defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; response to type I interferon [GO:0034340]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0006513; GO:0008270; GO:0032728; GO:0034340; GO:0045087; GO:0051607; GO:0060340; GO:0061630; GO:0070534
GN011796	GN011796.1	E1BD59	22.9	724	646	732	8.13e-49	185	TRI56_BOVIN	E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (Tripartite motif-containing protein 56)	Bos taurus (Bovine)	defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; response to type I interferon [GO:0034340]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0006513; GO:0008270; GO:0032728; GO:0034340; GO:0045087; GO:0051607; GO:0060340; GO:0061630; GO:0070534
GN011798	GN011798.1	Q0P5K1	29.8	292	453	473	2.81e-11	68.9	GPBP1_BOVIN	Vasculin (GC-rich promoter-binding protein 1)	Bos taurus (Bovine)	DNA-templated transcription [GO:0006351]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; RNA binding [GO:0003723]	nucleus [GO:0005634]	GO:0003677; GO:0003700; GO:0003723; GO:0005634; GO:0006351; GO:0006355; GO:0045893
GN011799	GN011799.1	Q1HCL7	46.4	390	424	425	1.93e-111	337	NADK2_RAT	NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial)	Rattus norvegicus (Rat)	NAD+ metabolic process [GO:0019674]; NADP+ biosynthetic process [GO:0006741]	NAD+ kinase activity [GO:0003951]; protein homodimerization activity [GO:0042803]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003951; GO:0005739; GO:0005759; GO:0006741; GO:0019674; GO:0042803
GN011800	GN011800.1	Q7T0W5	38.9	314	284	344	4.88e-70	223	TFB1M_XENLA	Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (mtTFB1) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1)	Xenopus laevis (African clawed frog)	rRNA methylation [GO:0031167]; transcription initiation at mitochondrial promoter [GO:0006391]	mitochondrial transcription factor activity [GO:0034246]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]; S-adenosyl-L-methionine binding [GO:1904047]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0000179; GO:0005739; GO:0005759; GO:0006391; GO:0031167; GO:0034246; GO:1904047
GN011802	GN011802.1	A2BIJ3	30.0	466	462	412	5.40e-46	167	BSDC1_DANRE	BSD domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]	GO:0005737
GN011806	GN011806.1	P98081	58.6	145	863	2224	3.12e-46	184	DAB_DROME	Protein disabled	Drosophila melanogaster (Fruit fly)	cellularization [GO:0007349]; clathrin-dependent endocytosis [GO:0072583]; compound eye photoreceptor development [GO:0042051]; dorsal closure [GO:0007391]; motor neuron axon guidance [GO:0008045]; mushroom body development [GO:0016319]; positive regulation of sevenless signaling pathway [GO:0045874]; receptor-mediated endocytosis [GO:0006898]; synaptic vesicle endocytosis [GO:0048488]	sevenless binding [GO:0005118]; signaling adaptor activity [GO:0035591]	axon [GO:0030424]; cytosol [GO:0005829]; presynapse [GO:0098793]	GO:0005118; GO:0005829; GO:0006898; GO:0007349; GO:0007391; GO:0008045; GO:0016319; GO:0030424; GO:0035591; GO:0042051; GO:0045874; GO:0048488; GO:0072583; GO:0098793
GN011807	GN011807.1	P14211	74.3	354	395	416	1.15e-139	407	CALR_MOUSE	Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP)	Mus musculus (Mouse)	cardiac muscle cell differentiation [GO:0055007]; cellular response to electrical stimulus [GO:0071257]; cellular response to lithium ion [GO:0071285]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; cortical actin cytoskeleton organization [GO:0030866]; ERAD pathway [GO:0036503]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translation [GO:0017148]; negative regulation of trophoblast cell migration [GO:1901164]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of phagocytosis [GO:0050766]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein export from nucleus [GO:0006611]; protein folding [GO:0006457]; protein localization to nucleus [GO:0034504]; protein maturation [GO:0051604]; protein stabilization [GO:0050821]; regulation of meiotic nuclear division [GO:0040020]; response to biphenyl [GO:1904614]; response to estradiol [GO:0032355]; response to glycoside [GO:1903416]; response to peptide [GO:1901652]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; complement component C1q complex binding [GO:0001849]; hormone binding [GO:0042562]; integrin binding [GO:0005178]; iron ion binding [GO:0005506]; molecular sequestering activity [GO:0140313]; mRNA binding [GO:0003729]; nuclear androgen receptor binding [GO:0050681]; nuclear export signal receptor activity [GO:0005049]; peptide binding [GO:0042277]; protein folding chaperone [GO:0044183]; protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase binding [GO:0031625]	acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; cortical granule [GO:0060473]; cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; external side of plasma membrane [GO:0009897]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; ribosome [GO:0005840]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790]	GO:0000122; GO:0001669; GO:0001849; GO:0002502; GO:0003729; GO:0005049; GO:0005178; GO:0005506; GO:0005509; GO:0005576; GO:0005634; GO:0005635; GO:0005737; GO:0005739; GO:0005783; GO:0005788; GO:0005790; GO:0005829; GO:0005840; GO:0006457; GO:0006611; GO:0007283; GO:0008284; GO:0009410; GO:0009897; GO:0009986; GO:0010595; GO:0010628; GO:0016020; GO:0016529; GO:0017148; GO:0030246; GO:0030674; GO:0030866; GO:0031012; GO:0031625; GO:0032355; GO:0032991; GO:0033018; GO:0033144; GO:0033574; GO:0034504; GO:0036503; GO:0040020; GO:0042277; GO:0042562; GO:0042824; GO:0044183; GO:0044194; GO:0044322; GO:0045335; GO:0045665; GO:0045787; GO:0045892; GO:0048387; GO:0048471; GO:0050681; GO:0050766; GO:0050821; GO:0051604; GO:0055007; GO:0060473; GO:0071257; GO:0071285; GO:0090398; GO:0098586; GO:0098794; GO:0098978; GO:0140313; GO:1900026; GO:1901164; GO:1901224; GO:1901652; GO:1903416; GO:1904614; GO:2000510
GN011808	GN011808.1	Q3T0Q2	29.5	258	251	323	5.07e-21	93.2	TMM59_BOVIN	Transmembrane protein 59	Bos taurus (Bovine)	positive regulation of autophagy [GO:0010508]		Golgi membrane [GO:0000139]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0000139; GO:0005764; GO:0005765; GO:0005770; GO:0005886; GO:0010508; GO:0031902
GN011809	GN011809.1	A0JN80	53.6	1021	1053	1053	0.0	1040	DI3L1_BOVIN	DIS3-like exonuclease 1 (EC 3.1.13.1)	Bos taurus (Bovine)	gene expression [GO:0010467]; mRNA catabolic process [GO:0006402]; rRNA catabolic process [GO:0016075]	3'-5'-RNA exonuclease activity [GO:0000175]; enzyme binding [GO:0019899]; exoribonuclease II activity [GO:0008859]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]	GO:0000175; GO:0000177; GO:0003723; GO:0005737; GO:0006402; GO:0008859; GO:0010467; GO:0016075; GO:0019899
GN011810	GN011810.1	Q91754	41.0	586	574	619	3.09e-147	441	GCKR_XENLA	Glucokinase regulatory protein (GKRP) (Glucokinase regulator)	Xenopus laevis (African clawed frog)	carbohydrate derivative metabolic process [GO:1901135]; intracellular glucose homeostasis [GO:0001678]; negative regulation of glucokinase activity [GO:0033132]; protein localization to nucleus [GO:0034504]; response to fructose [GO:0009750]	carbohydrate binding [GO:0030246]; enzyme binding [GO:0019899]; fructose-6-phosphate binding [GO:0070095]; glucose sensor activity [GO:0141089]; kinase inhibitor activity [GO:0019210]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001678; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0009750; GO:0019210; GO:0019899; GO:0030246; GO:0033132; GO:0034504; GO:0070095; GO:0141089; GO:1901135
GN011815	GN011815.1	Q9D7H3	53.2	233	231	366	1.89e-76	238	RTCA_MOUSE	RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1)	Mus musculus (Mouse)	negative regulation of optical nerve axon regeneration [GO:1905592]; RNA processing [GO:0006396]	RNA-3'-phosphate cyclase activity [GO:0003963]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003963; GO:0005634; GO:0005654; GO:0006396; GO:1905592
GN011821	GN011821.1	P13508	29.3	304	1612	1295	1.98e-15	86.3	GLP1_CAEEL	Protein glp-1 [Cleaved into: glp-1/Notch intracellular domain]	Caenorhabditis elegans	cell fate specification [GO:0001708]; cellularization [GO:0007349]; cytoplasmic streaming [GO:0099636]; embryonic pattern specification [GO:0009880]; maintenance of dauer [GO:0043055]; negative regulation of stem cell differentiation [GO:2000737]; nematode larval development [GO:0002119]; nematode pharyngeal muscle development [GO:0160096]; Notch signaling pathway [GO:0007219]; oocyte growth [GO:0001555]; positive regulation of gene expression [GO:0010628]; positive regulation of germ cell proliferation [GO:1905938]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of gene expression [GO:0010468]; regulation of germ cell proliferation [GO:1905936]; regulation of transcription by RNA polymerase II [GO:0006357]	calcium ion binding [GO:0005509]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transmembrane signaling receptor activity [GO:0004888]	axon [GO:0030424]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; lateral plasma membrane [GO:0016328]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0001555; GO:0001708; GO:0002119; GO:0003713; GO:0004888; GO:0005509; GO:0005634; GO:0005737; GO:0005886; GO:0006357; GO:0007219; GO:0007349; GO:0009880; GO:0010468; GO:0010608; GO:0010628; GO:0012505; GO:0016328; GO:0030424; GO:0043055; GO:0045944; GO:0061629; GO:0090575; GO:0099636; GO:0160096; GO:1905936; GO:1905938; GO:2000648; GO:2000737
GN011825	GN011825.1	Q5RA23	73.5	147	381	335	6.80e-61	202	NFYC_PONAB	Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)		DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	CCAAT-binding factor complex [GO:0016602]	GO:0000978; GO:0001228; GO:0016602; GO:0046982
GN011826	GN011826.1	Q9VQZ6	86.5	539	542	552	0.0	971	ELP3_DROME	Elongator complex protein 3 (EC 2.3.1.311) (EC 2.3.1.48) (tRNA uridine(34) acetyltransferase)	Drosophila melanogaster (Fruit fly)	cytoskeletal matrix organization at active zone [GO:0048789]; establishment of mitotic spindle asymmetry [GO:0061867]; hemopoiesis [GO:0030097]; instar larval development [GO:0002168]; locomotory behavior [GO:0007626]; long-term memory [GO:0007616]; regulation of photoreceptor cell axon guidance [GO:2000289]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of translation [GO:0006417]; sleep [GO:0030431]; synapse organization [GO:0050808]; synaptic assembly at neuromuscular junction [GO:0051124]; tRNA modification [GO:0006400]; tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation [GO:0002926]; tRNA wobble uridine modification [GO:0002098]	acetyltransferase activity [GO:0016407]; iron-sulfur cluster binding [GO:0051536]; protein-lysine-acetyltransferase activity [GO:0061733]; tRNA uridine(34) acetyltransferase activity [GO:0106261]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634]; presynapse [GO:0098793]; spindle [GO:0005819]; synapse [GO:0045202]	GO:0002098; GO:0002168; GO:0002926; GO:0005634; GO:0005737; GO:0005819; GO:0005829; GO:0006357; GO:0006400; GO:0006417; GO:0007616; GO:0007626; GO:0016407; GO:0030097; GO:0030431; GO:0033588; GO:0045202; GO:0048789; GO:0050808; GO:0051124; GO:0051536; GO:0061733; GO:0061867; GO:0098793; GO:0106261; GO:2000289
GN011827	GN011827.1	Q9DAT2	54.1	85	177	204	4.72e-26	101	MRGBP_MOUSE	MRG/MORF4L-binding protein (MRG-binding protein)	Mus musculus (Mouse)	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair [GO:2000779]; regulation of transcription by RNA polymerase II [GO:0006357]		NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]	GO:0000786; GO:0005654; GO:0006357; GO:0035267; GO:0042981; GO:0045893; GO:0051726; GO:1905168; GO:2000779
GN011828	GN011828.1	Q5R5P0	68.7	1162	1166	1159	0.0	1611	WASC5_PONAB	WASH complex subunit 5 (WASH complex subunit strumpellin)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	actin filament polymerization [GO:0030041]; endosome fission [GO:0140285]; endosome organization [GO:0007032]; regulation of actin nucleation [GO:0051125]		cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; WASH complex [GO:0071203]	GO:0005769; GO:0005783; GO:0005829; GO:0007032; GO:0030041; GO:0051125; GO:0071203; GO:0140285
GN011829	GN011829.1	Q92968	51.9	264	451	403	5.44e-76	246	PEX13_HUMAN	Peroxisomal membrane protein PEX13 (Peroxin-13)	Homo sapiens (Human)	cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; fatty acid alpha-oxidation [GO:0001561]; locomotory behavior [GO:0007626]; microtubule-based peroxisome localization [GO:0060152]; neuron migration [GO:0001764]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, translocation [GO:0016561]; suckling behavior [GO:0001967]	transmembrane protein transporter activity [GO:0008320]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0001561; GO:0001764; GO:0001967; GO:0005777; GO:0005778; GO:0005829; GO:0007626; GO:0008320; GO:0016020; GO:0016560; GO:0016561; GO:0021795; GO:0034614; GO:0060152; GO:1990429
GN011830	GN011830.1	Q92968	52.3	264	457	403	2.32e-76	247	PEX13_HUMAN	Peroxisomal membrane protein PEX13 (Peroxin-13)	Homo sapiens (Human)	cellular response to reactive oxygen species [GO:0034614]; cerebral cortex cell migration [GO:0021795]; fatty acid alpha-oxidation [GO:0001561]; locomotory behavior [GO:0007626]; microtubule-based peroxisome localization [GO:0060152]; neuron migration [GO:0001764]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, translocation [GO:0016561]; suckling behavior [GO:0001967]	transmembrane protein transporter activity [GO:0008320]	cytosol [GO:0005829]; membrane [GO:0016020]; peroxisomal importomer complex [GO:1990429]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0001561; GO:0001764; GO:0001967; GO:0005777; GO:0005778; GO:0005829; GO:0007626; GO:0008320; GO:0016020; GO:0016560; GO:0016561; GO:0021795; GO:0034614; GO:0060152; GO:1990429
GN011831	GN011831.1	Q6DYE8	48.3	236	485	874	1.21e-72	249	ENPP3_MOUSE	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Dinucleoside polyphosphatase) (EC 3.6.1.-) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c)	Mus musculus (Mouse)	ATP metabolic process [GO:0046034]; basophil activation involved in immune response [GO:0002276]; negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mast cell activation involved in immune response [GO:0033007]; negative regulation of mast cell proliferation [GO:0070667]; nucleoside triphosphate catabolic process [GO:0009143]; phosphate ion homeostasis [GO:0055062]; phosphate-containing compound metabolic process [GO:0006796]; pyrimidine nucleotide metabolic process [GO:0006220]	5'-nucleotidase activity [GO:0008253]; ATP diphosphatase activity [GO:0047693]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; bis(5'-adenosyl)-triphosphatase activity [GO:0047710]; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity [GO:0004081]; calcium ion binding [GO:0005509]; cyclic-GMP-AMP hydrolase activity [GO:0106177]; GTP diphosphatase activity [GO:0036219]; nucleic acid binding [GO:0003676]; nucleoside triphosphate diphosphatase activity [GO:0047429]; phosphodiesterase I activity [GO:0004528]; UTP diphosphatase activity [GO:0036221]; zinc ion binding [GO:0008270]	apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0002276; GO:0003676; GO:0004081; GO:0004528; GO:0005509; GO:0005576; GO:0005886; GO:0006220; GO:0006796; GO:0008253; GO:0008270; GO:0009143; GO:0009897; GO:0016324; GO:0033007; GO:0034432; GO:0036219; GO:0036221; GO:0046034; GO:0047429; GO:0047693; GO:0047710; GO:0048471; GO:0050728; GO:0055062; GO:0070667; GO:0106177; GO:0160049
GN011832	GN011832.1	J3SBP3	43.6	459	1468	810	6.93e-113	379	PDE2_CROAD	Venom phosphodiesterase 2 (PDE) (EC 3.6.1.-)	Crotalus adamanteus (Eastern diamondback rattlesnake)	nucleoside triphosphate catabolic process [GO:0009143]	ADP phosphatase activity [GO:0043262]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; nucleoside triphosphate diphosphatase activity [GO:0047429]	extracellular region [GO:0005576]	GO:0003676; GO:0005576; GO:0009143; GO:0043262; GO:0046872; GO:0047429
GN011833	GN011833.1	J3SBP3	34.9	106	74	810	1.54e-15	72.4	PDE2_CROAD	Venom phosphodiesterase 2 (PDE) (EC 3.6.1.-)	Crotalus adamanteus (Eastern diamondback rattlesnake)	nucleoside triphosphate catabolic process [GO:0009143]	ADP phosphatase activity [GO:0043262]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; nucleoside triphosphate diphosphatase activity [GO:0047429]	extracellular region [GO:0005576]	GO:0003676; GO:0005576; GO:0009143; GO:0043262; GO:0046872; GO:0047429
GN011834	GN011834.1	Q9VZW5	25.8	349	397	549	7.41e-14	76.6	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN011836	GN011836.1	P12270	31.8	1347	2489	2363	4.08e-145	509	TPR_HUMAN	Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)	Homo sapiens (Human)	cellular response to heat [GO:0034605]; cellular response to interferon-alpha [GO:0035457]; mitotic spindle assembly checkpoint signaling [GO:0007094]; mRNA export from nucleus in response to heat stress [GO:0031990]; negative regulation of RNA export from nucleus [GO:0046832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translational initiation [GO:0045947]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; positive regulation of heterochromatin formation [GO:0031453]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus [GO:0006606]; regulation of mitotic sister chromatid separation [GO:0010965]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein localization [GO:0032880]; response to epidermal growth factor [GO:0070849]; RNA export from nucleus [GO:0006405]; RNA import into nucleus [GO:0006404]	chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; heat shock protein binding [GO:0031072]; mitogen-activated protein kinase binding [GO:0051019]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; structural constituent of nuclear pore [GO:0017056]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000776; GO:0003682; GO:0003723; GO:0003729; GO:0005634; GO:0005635; GO:0005643; GO:0005654; GO:0005737; GO:0005868; GO:0006404; GO:0006405; GO:0006606; GO:0006913; GO:0006999; GO:0007094; GO:0010965; GO:0015631; GO:0017056; GO:0031072; GO:0031453; GO:0031965; GO:0031990; GO:0032880; GO:0034399; GO:0034605; GO:0035457; GO:0042307; GO:0042405; GO:0042803; GO:0044615; GO:0045947; GO:0046827; GO:0046832; GO:0051019; GO:0070840; GO:0070849; GO:0072686; GO:0090267; GO:0090316; GO:1901673
GN011837	GN011837.1	Q9UIF3	61.7	399	422	430	2.00e-153	444	TEKT2_HUMAN	Tektin-2 (Tektin-t) (Testicular tektin) (Testicular tektin B1-like protein) (TEKTB1) (Tektin-B1)	Homo sapiens (Human)	cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]; flagellated sperm motility [GO:0030317]		axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; centriole [GO:0005814]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; sperm head-tail coupling apparatus [GO:0120212]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0005634; GO:0005814; GO:0005815; GO:0005879; GO:0015630; GO:0030317; GO:0036126; GO:0060271; GO:0060294; GO:0097225; GO:0097228; GO:0120212; GO:0160111
GN011838	GN011838.1	P34056	57.4	427	445	437	2.31e-129	384	AP2A_MOUSE	Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)	Mus musculus (Mouse)	anterior neuropore closure [GO:0021506]; basement membrane organization [GO:0071711]; bone morphogenesis [GO:0060349]; cellular response to iron ion [GO:0071281]; cornea development in camera-type eye [GO:0061303]; embryonic body morphogenesis [GO:0010172]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; embryonic pattern specification [GO:0009880]; epidermis morphogenesis [GO:0048730]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; forebrain neuron development [GO:0021884]; forelimb morphogenesis [GO:0035136]; inner ear morphogenesis [GO:0042472]; keratinocyte development [GO:0003334]; kidney development [GO:0001822]; lens induction in camera-type eye [GO:0060235]; lens morphogenesis in camera-type eye [GO:0002089]; metanephric nephron development [GO:0072210]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell development [GO:0014032]; neural tube closure [GO:0001843]; oculomotor nerve formation [GO:0021623]; optic cup structural organization [GO:0003409]; optic vesicle morphogenesis [GO:0003404]; outflow tract morphogenesis [GO:0003151]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron differentiation [GO:0045664]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; roof of mouth development [GO:0060021]; sensory organ development [GO:0007423]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; sympathetic nervous system development [GO:0048485]; trigeminal nerve development [GO:0021559]	chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	clathrin-coated pit [GO:0005905]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0000987; GO:0001227; GO:0001228; GO:0001501; GO:0001822; GO:0001843; GO:0002089; GO:0003151; GO:0003334; GO:0003404; GO:0003409; GO:0003677; GO:0003682; GO:0003700; GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0005667; GO:0005905; GO:0006355; GO:0006357; GO:0007399; GO:0007423; GO:0007605; GO:0008285; GO:0009880; GO:0010172; GO:0010628; GO:0014032; GO:0021506; GO:0021559; GO:0021623; GO:0021884; GO:0030335; GO:0030501; GO:0032496; GO:0035115; GO:0035136; GO:0042059; GO:0042127; GO:0042472; GO:0042802; GO:0043066; GO:0043524; GO:0043525; GO:0043565; GO:0043588; GO:0045595; GO:0045664; GO:0045892; GO:0045893; GO:0045944; GO:0048485; GO:0048596; GO:0048701; GO:0048705; GO:0048730; GO:0060021; GO:0060235; GO:0060325; GO:0060349; GO:0061029; GO:0061303; GO:0070172; GO:0071281; GO:0071711; GO:0072210; GO:1990837; GO:2000378
GN011841	GN011841.1	Q1L987	30.4	253	319	302	3.77e-41	148	ATPF1_DANRE	ATP synthase mitochondrial F1 complex assembly factor 1	Danio rerio (Zebrafish) (Brachydanio rerio)	mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]	protein-containing complex stabilizing activity [GO:0140777]	mitochondrial inner membrane [GO:0005743]	GO:0005743; GO:0033615; GO:0140777
GN011843	GN011843.1	P49683	50.0	76	166	370	1.34e-13	70.5	PRLHR_HUMAN	Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G protein-coupled receptor 10) (hGR3)	Homo sapiens (Human)	feeding behavior [GO:0007631]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]	cilium [GO:0005929]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	GO:0004930; GO:0004983; GO:0005886; GO:0005929; GO:0007186; GO:0007218; GO:0007565; GO:0007631; GO:0008188; GO:0043005
GN011848	GN011848.1	F8W3R9	26.6	241	1202	1705	1.26e-12	76.6	ALK_DANRE	ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase 2) (alk-2) (Anaplastic lymphoma kinase homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; nervous system development [GO:0007399]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neurogenesis [GO:0050769]; protein N-linked glycosylation [GO:0006487]; regulation of cell population proliferation [GO:0042127]; regulation of neuron differentiation [GO:0045664]	ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004713; GO:0004714; GO:0005524; GO:0005886; GO:0006487; GO:0007169; GO:0007399; GO:0016020; GO:0042127; GO:0043235; GO:0043410; GO:0045664; GO:0050769
GN011849	GN011849.1	F8W3R9	27.0	241	809	1705	6.96e-13	76.6	ALK_DANRE	ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase 2) (alk-2) (Anaplastic lymphoma kinase homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; nervous system development [GO:0007399]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neurogenesis [GO:0050769]; protein N-linked glycosylation [GO:0006487]; regulation of cell population proliferation [GO:0042127]; regulation of neuron differentiation [GO:0045664]	ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004713; GO:0004714; GO:0005524; GO:0005886; GO:0006487; GO:0007169; GO:0007399; GO:0016020; GO:0042127; GO:0043235; GO:0043410; GO:0045664; GO:0050769
GN011850	GN011850.1	Q08DI6	65.6	160	150	154	3.74e-69	208	RNF11_BOVIN	RING finger protein 11	Bos taurus (Bovine)	protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]	early endosome [GO:0005769]; nucleus [GO:0005634]; recycling endosome [GO:0055037]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005634; GO:0005769; GO:0006511; GO:0051865; GO:0055037; GO:0061630
GN011853	GN011853.1	A6H603	25.5	753	1405	1563	1.11e-54	214	NWD1_MOUSE	NACHT domain- and WD repeat-containing protein 1	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; positive regulation of gene expression [GO:0010628]		cytosol [GO:0005829]; nucleolus [GO:0005730]	GO:0005730; GO:0005829; GO:0010628; GO:0035556
GN011854	GN011854.1	Q8AWB5	41.4	413	459	475	1.87e-108	332	OFUT3_CHICK	GDP-fucose protein O-fucosyltransferase 3 (EC 2.4.1.221) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)	Gallus gallus (Chicken)	N-glycan processing [GO:0006491]; positive regulation of protein secretion [GO:0050714]	alpha-(1->3)-fucosyltransferase activity [GO:0046920]; peptide-O-fucosyltransferase activity [GO:0046922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005783; GO:0005789; GO:0006491; GO:0046920; GO:0046922; GO:0050714
GN011855	GN011855.1	Q8AWB5	47.0	428	442	475	1.42e-136	403	OFUT3_CHICK	GDP-fucose protein O-fucosyltransferase 3 (EC 2.4.1.221) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)	Gallus gallus (Chicken)	N-glycan processing [GO:0006491]; positive regulation of protein secretion [GO:0050714]	alpha-(1->3)-fucosyltransferase activity [GO:0046920]; peptide-O-fucosyltransferase activity [GO:0046922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005783; GO:0005789; GO:0006491; GO:0046920; GO:0046922; GO:0050714
GN011856	GN011856.1	Q8AWB5	46.2	390	425	475	2.82e-118	356	OFUT3_CHICK	GDP-fucose protein O-fucosyltransferase 3 (EC 2.4.1.221) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)	Gallus gallus (Chicken)	N-glycan processing [GO:0006491]; positive regulation of protein secretion [GO:0050714]	alpha-(1->3)-fucosyltransferase activity [GO:0046920]; peptide-O-fucosyltransferase activity [GO:0046922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005783; GO:0005789; GO:0006491; GO:0046920; GO:0046922; GO:0050714
GN011857	GN011857.1	P69478	28.5	256	473	352	1.05e-22	102	CHSTB_RAT	Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4S-1) (C4ST-1) (C4ST1)	Rattus norvegicus (Rat)	carbohydrate biosynthetic process [GO:0016051]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; chondroitin sulfate proteoglycan metabolic process [GO:0050654]; developmental growth [GO:0048589]; embryonic digit morphogenesis [GO:0042733]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; embryonic viscerocranium morphogenesis [GO:0048703]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; polysaccharide localization [GO:0033037]; post-anal tail morphogenesis [GO:0036342]; post-embryonic development [GO:0009791]; proteoglycan biosynthetic process [GO:0030166]; regulation of cell population proliferation [GO:0042127]; respiratory gaseous exchange by respiratory system [GO:0007585]	chondroitin 4-sulfotransferase activity [GO:0047756]; dermatan 4-sulfotransferase activity [GO:0001537]; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity [GO:0050659]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]	GO:0000139; GO:0001537; GO:0001701; GO:0002063; GO:0007585; GO:0008146; GO:0009791; GO:0016051; GO:0030166; GO:0030326; GO:0030512; GO:0033037; GO:0036342; GO:0042127; GO:0042733; GO:0043066; GO:0047756; GO:0048589; GO:0048703; GO:0048704; GO:0050650; GO:0050654; GO:0050659; GO:0051216
GN011858	GN011858.1	Q920G9	51.8	427	655	524	3.01e-147	440	GMCL1_MOUSE	Germ cell-less protein-like 1 (mGcl-1) (DP-interacting protein) (DIP)	Mus musculus (Mouse)	germ cell development [GO:0007281]; regulation of DNA-templated transcription [GO:0006355]; spermatogenesis [GO:0007283]	cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]	nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]	GO:0005634; GO:0005635; GO:0006355; GO:0007281; GO:0007283; GO:0016363; GO:0042802; GO:0097602
GN011860	GN011860.1	Q499S9	41.3	783	732	856	5.99e-180	538	RHDF1_RAT	Inactive rhomboid protein 1 (iRhom1) (Rhomboid family member 1)	Rattus norvegicus (Rat)	cell migration [GO:0016477]; cell population proliferation [GO:0008283]; chaperone-mediated protein complex assembly [GO:0051131]; negative regulation of protein secretion [GO:0050709]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein secretion [GO:0050708]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005783; GO:0005789; GO:0008283; GO:0016477; GO:0042058; GO:0050708; GO:0050709; GO:0051131; GO:0061136
GN011863	GN011863.1	Q6INU8	78.9	606	610	651	0.0	974	IT70A_XENLA	Intraflagellar transport protein 70A (Tetratricopeptide repeat protein 30A) (TPR repeat protein 30A)	Xenopus laevis (African clawed frog)	intraciliary transport [GO:0042073]; protein polyglutamylation [GO:0018095]	intraciliary transport particle B binding [GO:0120170]	axonemal microtubule [GO:0005879]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]	GO:0005879; GO:0005929; GO:0018095; GO:0030992; GO:0042073; GO:0120170
GN011864	GN011864.1	Q6AZB8	37.4	99	415	349	3.49e-09	61.6	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN011865	GN011865.1	P81018	30.6	121	1194	190	1.66e-10	65.1	LADD_ONCMY	Ladderlectin	Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)		chitin binding [GO:0008061]	brush border [GO:0005903]; cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005576; GO:0005737; GO:0005829; GO:0005886; GO:0005903; GO:0008061; GO:0044194
GN011867	GN011867.1	P25931	39.8	304	359	464	8.41e-66	218	RYAR_DROME	RYamide receptor (Neuropeptide Y-like receptor) (NPY-R)	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0004983; GO:0005886; GO:0007186; GO:0007218; GO:0008188; GO:0016020
GN011873	GN011873.1	A6NCI4	42.0	1146	2098	1184	3.03e-289	875	VWA3A_HUMAN	von Willebrand factor A domain-containing protein 3A	Homo sapiens (Human)			extracellular region [GO:0005576]	GO:0005576
GN011874	GN011874.1	C3ZQF9	37.4	318	416	380	1.14e-55	191	QRFPR_BRAFL	QRFP-like peptide receptor	Branchiostoma floridae (Florida lancelet) (Amphioxus)	cellular response to hormone stimulus [GO:0032870]; cellular response to peptide [GO:1901653]; G protein-coupled receptor signaling pathway [GO:0007186]	G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]	plasma membrane [GO:0005886]	GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0032870; GO:1901653
GN011883	GN011883.1	Q96DM1	25.0	140	151	585	4.46e-12	65.9	PGBD4_HUMAN	PiggyBac transposable element-derived protein 4	Homo sapiens (Human)				
GN011884	GN011884.1	Q90596	52.6	97	121	156	2.46e-23	91.3	MAFK_CHICK	Transcription factor MafK	Gallus gallus (Chicken)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]	GO:0000976; GO:0000978; GO:0000981; GO:0003700; GO:0005634; GO:0006357; GO:0043565
GN011885	GN011885.1	Q29RM5	28.9	190	699	653	7.27e-12	72.4	FEM1A_BOVIN	Protein fem-1 homolog A (FEM1a) (FEM1-alpha)	Bos taurus (Bovine)	negative regulation of inflammatory response [GO:0050728]; positive regulation of inflammatory response [GO:0050729]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	EP4 subtype prostaglandin E2 receptor binding [GO:0031867]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005654; GO:0005737; GO:0005739; GO:0005794; GO:0016567; GO:0031462; GO:0031867; GO:0043161; GO:0050728; GO:0050729; GO:0140627; GO:1990756
GN011886	GN011886.1	Q6ZUK4	31.0	281	336	368	8.41e-33	128	TMM26_HUMAN	Transmembrane protein 26	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN011889	GN011889.1	P41243	44.3	149	171	467	3.21e-35	130	MATK_RAT	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Protein kinase BATK) (Tyrosine-protein kinase CTK)	Rattus norvegicus (Rat)		ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0004715; GO:0005524; GO:0005829; GO:0005886
GN011891	GN011891.1	Q5ZLN0	57.6	543	549	603	8.07e-74	249	LRC40_CHICK	Leucine-rich repeat-containing protein 40	Gallus gallus (Chicken)				
GN011893	GN011893.1	O35161	29.9	214	326	3034	7.35e-13	73.2	CELR1_MOUSE	Cadherin EGF LAG seven-pass G-type receptor 1	Mus musculus (Mouse)	anterior/posterior pattern specification [GO:0009952]; apical protein localization [GO:0045176]; axonogenesis [GO:0007409]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion mediated by cadherin [GO:0044331]; establishment of body hair planar orientation [GO:0048105]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; hair follicle development [GO:0001942]; homophilic cell-cell adhesion [GO:0007156]; inner ear morphogenesis [GO:0042472]; lateral sprouting involved in lung morphogenesis [GO:0060490]; locomotory behavior [GO:0007626]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060488]; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060489]; protein localization involved in establishment of planar polarity [GO:0090251]; regulation of actin cytoskeleton organization [GO:0032956]; Rho protein signal transduction [GO:0007266]; wound healing [GO:0042060]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]	adherens junction [GO:0005912]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0001736; GO:0001764; GO:0001843; GO:0001942; GO:0004930; GO:0005509; GO:0005654; GO:0005886; GO:0005912; GO:0007156; GO:0007166; GO:0007266; GO:0007409; GO:0007626; GO:0009952; GO:0016020; GO:0032956; GO:0042060; GO:0042249; GO:0042472; GO:0044331; GO:0045176; GO:0048105; GO:0060488; GO:0060489; GO:0060490; GO:0090251
GN011894	GN011894.1	E1BMV3	33.7	169	1101	544	1.87e-17	90.9	MATN1_BOVIN	Matrilin-1 (Cartilage matrix protein)	Bos taurus (Bovine)	extracellular matrix organization [GO:0030198]	calcium ion binding [GO:0005509]	extracellular matrix [GO:0031012]; matrilin complex [GO:0120216]	GO:0005509; GO:0030198; GO:0031012; GO:0120216
GN011895	GN011895.1	P18461	34.0	294	1258	823	3.28e-40	164	FGFR2_CHICK	Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (Tyrosine kinase receptor CEK3)	Gallus gallus (Chicken)	angiogenesis [GO:0001525]; animal organ development [GO:0048513]; fibroblast growth factor receptor signaling pathway [GO:0008543]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of cell differentiation [GO:0045595]; skeletal system development [GO:0001501]	ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]	cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001501; GO:0001525; GO:0005007; GO:0005524; GO:0005794; GO:0005886; GO:0008284; GO:0008543; GO:0017134; GO:0031410; GO:0043235; GO:0043410; GO:0045595; GO:0048513
GN011896	GN011896.1	P62025	40.5	566	543	569	2.34e-29	125	PHAR2_RAT	Phosphatase and actin regulator 2	Rattus norvegicus (Rat)	actin cytoskeleton organization [GO:0030036]	actin binding [GO:0003779]		GO:0003779; GO:0030036
GN011897	GN011897.1	Q9JI92	55.5	308	308	300	3.19e-111	327	SDCB1_RAT	Syntenin-1 (Syndecan-binding protein 1)	Rattus norvegicus (Rat)	negative regulation of receptor internalization [GO:0002091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; presynapse assembly [GO:0099054]; Ras protein signal transduction [GO:0007265]; regulation of mitotic cell cycle [GO:0007346]	cell adhesion molecule binding [GO:0050839]; ephrin receptor binding [GO:0046875]; frizzled binding [GO:0005109]; growth factor binding [GO:0019838]; identical protein binding [GO:0042802]; interleukin-5 receptor binding [GO:0005137]; ionotropic glutamate receptor binding [GO:0035255]; neurexin family protein binding [GO:0042043]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein sequestering activity [GO:0140311]; protein-containing complex binding [GO:0044877]; syndecan binding [GO:0045545]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; interleukin-5 receptor complex [GO:0005895]; melanosome [GO:0042470]; membrane raft [GO:0045121]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0000122; GO:0002091; GO:0005109; GO:0005137; GO:0005546; GO:0005654; GO:0005737; GO:0005789; GO:0005829; GO:0005856; GO:0005886; GO:0005895; GO:0005912; GO:0005925; GO:0007265; GO:0007346; GO:0008284; GO:0010718; GO:0019838; GO:0030307; GO:0030335; GO:0030511; GO:0031965; GO:0035255; GO:0042043; GO:0042327; GO:0042470; GO:0042802; GO:0044877; GO:0045121; GO:0045545; GO:0046875; GO:0046982; GO:0050839; GO:0070062; GO:0098793; GO:0099054; GO:0140311; GO:1903543; GO:1903553
GN011898	GN011898.1	P27447	62.7	451	517	544	1.69e-202	577	YES_XIPHE	Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)	Xiphophorus hellerii (Green swordtail)	tissue development [GO:0009888]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]		GO:0004715; GO:0005524; GO:0009888
GN011899	GN011899.1	Q69ZJ7	43.5	1371	1363	1422	0.0	1043	RIC1_MOUSE	Guanine nucleotide exchange factor subunit RIC1 (Protein RIC1 homolog) (RAB6A-GEF complex partner protein 1)	Mus musculus (Mouse)	cranial skeletal system development [GO:1904888]; intracellular protein transport [GO:0006886]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of GTPase activity [GO:0043547]; regulation of extracellular matrix constituent secretion [GO:0003330]; retrograde transport, endosome to Golgi [GO:0042147]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; Ric1-Rgp1 guanyl-nucleotide exchange factor complex [GO:0034066]	GO:0000139; GO:0003330; GO:0005085; GO:0005829; GO:0006886; GO:0016020; GO:0031267; GO:0032991; GO:0034066; GO:0042147; GO:0042177; GO:0043547; GO:1904888
GN011900	GN011900.1	A2VDD2	54.3	175	173	176	2.77e-63	195	DYL5B_XENLA	Dynein light chain Tctex-type 5-B (Tctex1 domain-containing protein 1-B)	Xenopus laevis (African clawed frog)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505
GN011901	GN011901.1	Q5VWJ9	44.9	401	502	437	8.19e-112	341	SNX30_HUMAN	Sorting nexin-30	Homo sapiens (Human)	endocytic recycling [GO:0032456]; mitophagy [GO:0000423]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of autophagosome assembly [GO:2000786]; protein transport [GO:0015031]; reticulophagy [GO:0061709]	phosphatidylinositol binding [GO:0035091]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; phagophore assembly site [GO:0000407]	GO:0000407; GO:0000423; GO:0005769; GO:0015031; GO:0031901; GO:0032456; GO:0034727; GO:0035091; GO:0061709; GO:2000786
GN011902	GN011902.1	Q6ZNA5	27.2	614	748	592	1.53e-62	223	FRRS1_HUMAN	Ferric reductase 1 (EC 1.-.-.-) (Ferric-chelate reductase 1) (Stromal cell-derived receptor 2) (SDR-2)	Homo sapiens (Human)	intracellular iron ion homeostasis [GO:0006879]	oxidoreductase activity, acting on metal ions [GO:0016722]	membrane [GO:0016020]	GO:0006879; GO:0016020; GO:0016722
GN011903	GN011903.1	Q9Y366	65.7	429	442	437	9.66e-200	562	IFT52_HUMAN	Intraflagellar transport protein 52 homolog (Protein NGD5 homolog)	Homo sapiens (Human)	cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; dendrite terminus [GO:0044292]; intraciliary transport particle A [GO:0030991]; intraciliary transport particle B [GO:0030992]; motile cilium [GO:0031514]; photoreceptor connecting cilium [GO:0032391]	GO:0005813; GO:0005814; GO:0005929; GO:0030991; GO:0030992; GO:0031514; GO:0032391; GO:0035720; GO:0036064; GO:0042073; GO:0044292; GO:0060271; GO:0097542; GO:0097546
GN011904	GN011904.1	Q71R50	54.7	254	248	255	3.55e-89	267	DHR11_CHICK	Dehydrogenase/reductase SDR family member 11 (17-beta-hydroxysteroid dehydrogenase) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (Short-chain dehydrogenase/reductase family 24C member 1)	Gallus gallus (Chicken)	estrogen biosynthetic process [GO:0006703]	17-beta-hydroxysteroid dehydrogenase (NADP+) activity [GO:0072582]; 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity [GO:0000253]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]	extracellular region [GO:0005576]	GO:0000253; GO:0004303; GO:0005576; GO:0006703; GO:0072582
GN011905	GN011905.1	Q9UPG8	42.8	180	1168	496	1.77e-37	151	PLAL2_HUMAN	Zinc finger protein PLAGL2 (Pleiomorphic adenoma-like protein 2)	Homo sapiens (Human)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000981; GO:0001228; GO:0003700; GO:0005634; GO:0006357; GO:0043565
GN011908	GN011908.1	Q969P5	32.1	358	332	355	2.63e-50	174	FBX32_HUMAN	F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx)	Homo sapiens (Human)	negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process [GO:0062026]; protein ubiquitination [GO:0016567]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; Z disc [GO:0030018]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0014894; GO:0016567; GO:0019005; GO:0030018; GO:0031146; GO:0062026; GO:1990756
GN011915	GN011915.1	Q5FWF5	44.0	200	625	840	9.83e-47	180	ESCO1_HUMAN	N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1)	Homo sapiens (Human)	peptidyl-lysine acetylation [GO:0018394]; post-translational protein acetylation [GO:0034421]; regulation of DNA replication [GO:0006275]; sister chromatid cohesion [GO:0007062]	acetyltransferase activity [GO:0016407]; identical protein binding [GO:0042802]; N-acetyltransferase activity [GO:0008080]; protein-lysine-acetyltransferase activity [GO:0061733]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0005694; GO:0006275; GO:0007062; GO:0008080; GO:0008270; GO:0016407; GO:0018394; GO:0034421; GO:0042802; GO:0061733
GN011916	GN011916.1	Q8N0N9	55.0	402	407	405	5.57e-158	454	ODH_HALDH	Opine dehydrogenase (EC 1.5.1.-)	Haliotis discus hannai (Japanese abalone)		oxidoreductase activity [GO:0016491]		GO:0016491
GN011917	GN011917.1	Q8N0N9	54.3	400	405	405	1.59e-154	445	ODH_HALDH	Opine dehydrogenase (EC 1.5.1.-)	Haliotis discus hannai (Japanese abalone)		oxidoreductase activity [GO:0016491]		GO:0016491
GN011921	GN011921.1	B6LS00	56.5	92	92	92	2.34e-35	118	U728_BRAFL	UPF0728 protein	Branchiostoma floridae (Florida lancelet) (Amphioxus)				
GN011922	GN011922.1	B3NYF7	65.5	223	268	283	2.44e-96	287	NFU1_DROER	NFU1 iron-sulfur cluster scaffold homolog, mitochondrial	Drosophila erecta (Fruit fly)	iron-sulfur cluster assembly [GO:0016226]	iron ion binding [GO:0005506]; iron-sulfur cluster binding [GO:0051536]	mitochondrion [GO:0005739]	GO:0005506; GO:0005739; GO:0016226; GO:0051536
GN011924	GN011924.1	Q5SVZ6	28.7	691	879	1142	7.63e-68	249	ZMYM1_HUMAN	Zinc finger MYM-type protein 1	Homo sapiens (Human)		protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0005634; GO:0008270; GO:0046983
GN011926	GN011926.1	Q6TH15	67.4	530	1175	552	2.70e-248	718	EIF3D_DANRE	Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7)	Danio rerio (Zebrafish) (Brachydanio rerio)	cap-dependent translational initiation [GO:0002191]; formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	mRNA cap binding [GO:0098808]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]	GO:0001732; GO:0002191; GO:0003723; GO:0003743; GO:0005852; GO:0006413; GO:0016282; GO:0033290; GO:0098808
GN011928	GN011928.1	Q16222	65.0	237	238	522	2.08e-102	309	UAP1_HUMAN	UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; positive regulation of type I interferon production [GO:0032481]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	identical protein binding [GO:0042802]; protein serine pyrophosphorylase activity [GO:0141090]; UDP-N-acetylgalactosamine diphosphorylase activity [GO:0052630]; UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977]	cytosol [GO:0005829]	GO:0003977; GO:0005829; GO:0006048; GO:0032481; GO:0042802; GO:0052630; GO:0140374; GO:0141090
GN011929	GN011929.1	Q13231	49.6	379	676	466	2.19e-127	388	CHIT1_HUMAN	Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide digestion [GO:0044245]; response to bacterium [GO:0009617]	chitin binding [GO:0008061]; chitinase activity [GO:0004568]; endochitinase activity [GO:0008843]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	extracellular region [GO:0005576]; lysosome [GO:0005764]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	GO:0004553; GO:0004568; GO:0005576; GO:0005764; GO:0005975; GO:0006032; GO:0006955; GO:0008061; GO:0008843; GO:0009617; GO:0035580; GO:0044245; GO:1904724
GN011931	GN011931.1	Q4R6X9	57.9	522	515	523	9.51e-131	393	DRC3_MACFA	Dynein regulatory complex subunit 3 (Leucine-rich repeat-containing protein 48)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)			axoneme [GO:0005930]; sperm flagellum [GO:0036126]	GO:0005930; GO:0036126
GN011932	GN011932.1	Q1LZ96	53.5	241	258	289	7.78e-89	268	ATPF2_BOVIN	ATP synthase mitochondrial F1 complex assembly factor 2	Bos taurus (Bovine)	mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]	protein folding chaperone [GO:0044183]	mitochondrial inner membrane [GO:0005743]; nuclear speck [GO:0016607]	GO:0005743; GO:0016607; GO:0033615; GO:0044183
GN011933	GN011933.1	Q9CPY6	81.8	170	181	217	1.17e-108	312	GID4_MOUSE	Glucose-induced degradation protein 4 homolog (Vacuolar import and degradation protein 24 homolog)	Mus musculus (Mouse)			ubiquitin ligase complex [GO:0000151]	GO:0000151
GN011934	GN011934.1	Q61103	45.5	404	512	391	1.86e-97	303	REQU_MOUSE	Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)	Mus musculus (Mouse)	chromatin remodeling [GO:0006338]; negative regulation of myeloid progenitor cell differentiation [GO:1905454]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of DNA-templated transcription [GO:0006355]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H3K14ac reader activity [GO:0140015]; histone H4K16ac reader activity [GO:0140046]; transcription coregulator activity [GO:0003712]	centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]	GO:0000785; GO:0003712; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0006338; GO:0006355; GO:0006357; GO:0016514; GO:0030071; GO:0070316; GO:0140015; GO:0140046; GO:1902459; GO:1905454; GO:2000045; GO:2000781; GO:2000819
GN011935	GN011935.1	Q8NCG7	37.1	588	592	672	5.49e-120	373	DGLB_HUMAN	Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)	Homo sapiens (Human)	arachidonate metabolic process [GO:0019369]; diacylglycerol catabolic process [GO:0046340]; neurogenesis [GO:0022008]; positive regulation of triglyceride catabolic process [GO:0010898]; prostaglandin biosynthetic process [GO:0001516]; regulation of inflammatory response [GO:0050727]	lipase activity [GO:0016298]; monoacylglycerol lipase activity [GO:0047372]; triacylglycerol lipase activity [GO:0004806]	lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	GO:0001516; GO:0004806; GO:0005765; GO:0005886; GO:0010898; GO:0016298; GO:0019369; GO:0022008; GO:0046340; GO:0047372; GO:0050727
GN011943	GN011943.1	Q61425	64.0	314	310	314	6.00e-137	393	HCDH_MOUSE	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)	Mus musculus (Mouse)	fatty acid beta-oxidation [GO:0006635]; negative regulation of insulin secretion [GO:0046676]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of insulin secretion [GO:0050796]; response to activity [GO:0014823]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0003857]; identical protein binding [GO:0042802]; long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0016509]; NAD+ binding [GO:0070403]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0003857; GO:0005654; GO:0005737; GO:0005739; GO:0005743; GO:0005759; GO:0005829; GO:0006635; GO:0009410; GO:0014823; GO:0016509; GO:0032868; GO:0042802; GO:0046676; GO:0050796; GO:0070403; GO:0120162
GN011948	GN011948.1	O93530	28.4	436	423	1436	1.53e-37	149	WRN_XENLA	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Focus-forming activity 1) (FFA-1) (Werner syndrome protein homolog) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Xenopus laevis (African clawed frog)	DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; four-way junction helicase activity [GO:0009378]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000723; GO:0000724; GO:0000781; GO:0003676; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006259; GO:0006260; GO:0008408; GO:0009378; GO:0016887; GO:0030145; GO:0032392; GO:0043138
GN011950	GN011950.1	Q7ZVJ8	45.1	204	205	206	8.94e-60	189	MTL26_DANRE	Methyltransferase-like 26	Danio rerio (Zebrafish) (Brachydanio rerio)				
GN011951	GN011951.1	Q70CQ4	36.7	682	1252	1352	6.47e-112	385	UBP31_HUMAN	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31)	Homo sapiens (Human)	protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]	nucleus [GO:0005634]	GO:0004843; GO:0005634; GO:0016579
GN011952	GN011952.1	P24528	38.2	173	213	209	2.90e-33	121	MGMT_RAT	Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)	Rattus norvegicus (Rat)	cellular response to ionizing radiation [GO:0071479]; cellular response to oxidative stress [GO:0034599]; DNA alkylation repair [GO:0006307]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]	calcium ion binding [GO:0005509]; methylated-DNA-[protein]-cysteine S-methyltransferase activity [GO:0003908]; methyltransferase activity [GO:0008168]	nucleoplasm [GO:0005654]	GO:0003908; GO:0005509; GO:0005654; GO:0006281; GO:0006307; GO:0006974; GO:0008168; GO:0009410; GO:0009636; GO:0034599; GO:0043066; GO:0045471; GO:0045739; GO:0051593; GO:0060644; GO:0071479; GO:2000781
GN011953	GN011953.1	P36874	73.2	291	295	323	1.36e-164	462	PP1GA_XENLA	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit A (PP-1G-A) (xPP1-gamma1) (EC 3.1.3.16)	Xenopus laevis (African clawed frog)	mitotic nuclear membrane reassembly [GO:0007084]; protein dephosphorylation [GO:0006470]; regulation of circadian rhythm [GO:0042752]	protein serine/threonine phosphatase activity [GO:0004722]	cleavage furrow [GO:0032154]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]	GO:0004722; GO:0005730; GO:0005739; GO:0006470; GO:0007084; GO:0016020; GO:0016607; GO:0030496; GO:0032154; GO:0042752
GN011955	GN011955.1	P27046	35.2	1011	1073	1150	2.66e-181	563	MA2A1_MOUSE	Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)	Mus musculus (Mouse)	in utero embryonic development [GO:0001701]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; mannose metabolic process [GO:0006013]; mitochondrion organization [GO:0007005]; N-glycan processing [GO:0006491]; positive regulation of neurogenesis [GO:0050769]; respiratory gaseous exchange by respiratory system [GO:0007585]; retina morphogenesis in camera-type eye [GO:0060042]; vacuole organization [GO:0007033]	carbohydrate binding [GO:0030246]; hydrolase activity [GO:0016787]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]; identical protein binding [GO:0042802]; mannosidase activity [GO:0015923]; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]; protein homodimerization activity [GO:0042803]	cis-Golgi network [GO:0005801]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]	GO:0000139; GO:0001701; GO:0001889; GO:0004572; GO:0005576; GO:0005794; GO:0005797; GO:0005801; GO:0006013; GO:0006491; GO:0007005; GO:0007033; GO:0007585; GO:0015923; GO:0016787; GO:0016799; GO:0030246; GO:0042802; GO:0042803; GO:0048286; GO:0050769; GO:0060042
GN011956	GN011956.1	O08810	80.9	972	1036	971	0.0	1570	U5S1_MOUSE	116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; U5 snRNA binding [GO:0030623]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type catalytic step 2 spliceosome [GO:0071018]; U12-type precatalytic spliceosome [GO:0071016]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	GO:0000398; GO:0003924; GO:0005525; GO:0005634; GO:0005654; GO:0005681; GO:0005829; GO:0015030; GO:0016607; GO:0030623; GO:0046540; GO:0071005; GO:0071006; GO:0071007; GO:0071011; GO:0071013; GO:0071014; GO:0071016; GO:0071018; GO:0071020
GN011957	GN011957.1	Q3UP23	32.2	149	249	366	2.46e-13	72.0	TMM26_MOUSE	Transmembrane protein 26	Mus musculus (Mouse)			membrane [GO:0016020]	GO:0016020
GN011958	GN011958.1	A8E534	30.0	250	485	406	2.60e-15	81.3	KDM8_DANRE	Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5)	Danio rerio (Zebrafish) (Brachydanio rerio)	circadian regulation of gene expression [GO:0032922]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; protein destabilization [GO:0031648]	chromatin binding [GO:0003682]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; peptidyl-arginine 3-dioxygenase activity [GO:0106157]	nucleus [GO:0005634]	GO:0000086; GO:0003682; GO:0005634; GO:0031648; GO:0032922; GO:0045892; GO:0045893; GO:0051864; GO:0106157; GO:0140680
GN011959	GN011959.1	Q9UKN7	32.9	2772	2731	3530	0.0	1219	MYO15_HUMAN	Unconventional myosin-XV (Unconventional myosin-15)	Homo sapiens (Human)	endocytosis [GO:0006897]; response to light stimulus [GO:0009416]; sensory perception of sound [GO:0007605]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]	actin cytoskeleton [GO:0015629]; actin-based cell projection [GO:0098858]; extracellular exosome [GO:0070062]; myosin complex [GO:0016459]; stereocilium [GO:0032420]	GO:0003774; GO:0005524; GO:0006897; GO:0007605; GO:0009416; GO:0015629; GO:0016459; GO:0032420; GO:0051015; GO:0070062; GO:0098858
GN011960	GN011960.1	Q9NPB1	49.0	198	314	228	1.17e-64	206	NT5M_HUMAN	5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2)	Homo sapiens (Human)	deoxyribonucleotide catabolic process [GO:0009264]; dGMP catabolic process [GO:0046055]; DNA replication [GO:0006260]; dTMP catabolic process [GO:0046074]; dUMP catabolic process [GO:0046079]; GMP catabolic process [GO:0046038]; pyrimidine deoxyribonucleotide catabolic process [GO:0009223]; TMP catabolic process [GO:0046045]; UMP catabolic process [GO:0046050]	3'-nucleotidase activity [GO:0008254]; 5'-deoxynucleotidase activity [GO:0002953]; 5'-nucleotidase activity [GO:0008253]; nucleotidase activity [GO:0008252]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0002953; GO:0005739; GO:0005759; GO:0006260; GO:0008252; GO:0008253; GO:0008254; GO:0009223; GO:0009264; GO:0046038; GO:0046045; GO:0046050; GO:0046055; GO:0046074; GO:0046079
GN011963	GN011963.1	Q0II70	35.1	151	144	155	1.09e-15	72.4	MCRI2_BOVIN	MAPK regulated corepressor interacting protein 2 (Protein FAM195A)	Bos taurus (Bovine)			cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0010494
GN011964	GN011964.1	Q96JH8	27.4	1213	1228	1075	8.66e-91	320	RADIL_HUMAN	Ras-associating and dilute domain-containing protein	Homo sapiens (Human)	neural crest cell migration [GO:0001755]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]	GTPase binding [GO:0051020]	microtubule [GO:0005874]; protein-containing complex [GO:0032991]	GO:0001755; GO:0005874; GO:0007165; GO:0032991; GO:0034446; GO:0051020
GN011965	GN011965.1	Q5BJT4	43.9	180	388	343	5.67e-38	142	TXD15_RAT	Thioredoxin domain-containing protein 15	Rattus norvegicus (Rat)	cilium assembly [GO:0060271]; positive regulation of smoothened signaling pathway [GO:0045880]		ciliary membrane [GO:0060170]; cilium [GO:0005929]	GO:0005929; GO:0045880; GO:0060170; GO:0060271
GN011995	GN011995.1	Q9VV87	56.5	255	266	316	4.39e-99	295	ELOV6_DROME	Very long chain fatty acid elongase 6 (ELOVL6) (EC 2.3.1.199) (Elongation of very long chain fatty acids protein 6) (Neighbor of abl) (Very-long-chain 3-oxoacyl-CoA synthase)	Drosophila melanogaster (Fruit fly)	fatty acid elongation [GO:0030497]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty acid biosynthetic process [GO:0042759]; sphingolipid biosynthetic process [GO:0030148]	fatty acid elongase activity [GO:0009922]	endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]	GO:0005741; GO:0005789; GO:0009922; GO:0019367; GO:0030148; GO:0030497; GO:0034625; GO:0034626; GO:0042759
GN011996	GN011996.1	Q61241	43.0	263	287	365	2.42e-76	239	TSSK1_MOUSE	Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) (Serine/threonine-protein kinase 22A)	Mus musculus (Mouse)	gene expression [GO:0010467]; skin development [GO:0043588]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; motile cilium [GO:0031514]	GO:0000287; GO:0001669; GO:0004674; GO:0005524; GO:0007283; GO:0007286; GO:0010467; GO:0031514; GO:0043588; GO:0044877; GO:0106310
GN011997	GN011997.1	Q8R3P7	59.9	367	398	413	5.66e-130	382	IFT38_MOUSE	Intraflagellar transport protein 38 (Clusterin-associated protein 1) (Qilin)	Mus musculus (Mouse)	axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; floor plate formation [GO:0021508]; heart looping [GO:0001947]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; left/right pattern formation [GO:0060972]; neural tube closure [GO:0001843]; smoothened signaling pathway [GO:0007224]		actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]; intraciliary transport particle B [GO:0030992]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001843; GO:0001947; GO:0005634; GO:0005654; GO:0005813; GO:0005815; GO:0005929; GO:0007224; GO:0015629; GO:0021508; GO:0030991; GO:0030992; GO:0035082; GO:0035720; GO:0042073; GO:0060271; GO:0060972; GO:0097542; GO:0097546
GN011998	GN011998.1	P07511	69.7	452	473	484	5.09e-231	645	GLYC_RABIT	Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (L-allo-threonine/L-threonine aldolase SHMT1) (Serine methylase)	Oryctolagus cuniculus (Rabbit)	'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; cellular response to tetrahydrofolate [GO:1904482]; DNA replication [GO:0006260]; dTMP biosynthetic process [GO:0006231]; folic acid metabolic process [GO:0046655]; glycine metabolic process [GO:0006544]; L-serine catabolic process [GO:0006565]; L-serine metabolic process [GO:0006563]; protein homotetramerization [GO:0051289]; purine nucleobase biosynthetic process [GO:0009113]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	glycine hydroxymethyltransferase activity [GO:0004372]; hydroxytrimethyllysine aldolase activity [GO:0120567]; L-allo-threonine aldolase activity [GO:0008732]; lamin binding [GO:0005521]; mRNA 5'-UTR binding [GO:0048027]; mRNA regulatory element binding translation repressor activity [GO:0000900]; phenylserine aldolase activity [GO:0050179]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]; threonine aldolase activity [GO:0004793]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000900; GO:0004372; GO:0004793; GO:0005521; GO:0005634; GO:0005657; GO:0005737; GO:0005739; GO:0005829; GO:0006207; GO:0006231; GO:0006260; GO:0006544; GO:0006563; GO:0006565; GO:0008732; GO:0009113; GO:0030170; GO:0035999; GO:0042803; GO:0046653; GO:0046655; GO:0048027; GO:0050179; GO:0051289; GO:0070905; GO:0120567; GO:1904482
GN012000	GN012000.1	D3YZI9	32.2	121	251	523	6.73e-09	59.3	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN012001	GN012001.1	O94988	28.8	1097	1045	1023	1.82e-78	281	FA13A_HUMAN	Protein FAM13A	Homo sapiens (Human)	regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]	GO:0005096; GO:0005829; GO:0007165; GO:0051056
GN012002	GN012002.1	B1YMY4	54.0	398	432	392	5.93e-151	436	RHMD_BURA4	L-rhamnonate dehydratase (RhamD) (EC 4.2.1.90)	Burkholderia ambifaria (strain MC40-6)	amino acid catabolic process [GO:0009063]; carbohydrate catabolic process [GO:0016052]	L-rhamnonate dehydratase activity [GO:0050032]; magnesium ion binding [GO:0000287]		GO:0000287; GO:0009063; GO:0016052; GO:0050032
GN012004	GN012004.1	Q5JI69	37.6	348	354	350	1.16e-71	229	TDH_THEKO	L-threonine 3-dehydrogenase (TDH) (EC 1.1.1.103) (L-threonine dehydrogenase)	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))	L-threonine catabolic process [GO:0006567]; L-threonine metabolic process [GO:0006566]; protein homotetramerization [GO:0051289]	amino acid binding [GO:0016597]; L-threonine 3-dehydrogenase activity [GO:0008743]; NAD+ binding [GO:0070403]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0006566; GO:0006567; GO:0008270; GO:0008743; GO:0016597; GO:0051289; GO:0070403
GN012005	GN012005.1	O35920	38.4	687	680	690	4.89e-156	469	CAN9_RAT	Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (New calpain 4) (nCL-4)	Rattus norvegicus (Rat)	proteolysis [GO:0006508]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cytoplasm [GO:0005737]	GO:0004198; GO:0005509; GO:0005737; GO:0006508
GN012006	GN012006.1	Q5RCN6	53.5	480	510	525	1.36e-177	512	CP4V2_PONAB	Cytochrome P450 4V2 (Docosahexaenoic acid omega-hydroxylase CYP4V2) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	fatty acid omega-oxidation [GO:0010430]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; medium-chain fatty acid omega-hydroxylase activity [GO:0140981]	endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005789; GO:0010430; GO:0020037; GO:0102033; GO:0140981
GN012007	GN012007.1	Q501J6	72.0	439	676	650	2.18e-233	665	DDX17_MOUSE	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17)	Mus musculus (Mouse)	alternative mRNA splicing, via spliceosome [GO:0000380]; androgen receptor signaling pathway [GO:0030521]; epithelial to mesenchymal transition [GO:0001837]; estrogen receptor signaling pathway [GO:0030520]; gene expression [GO:0010467]; miRNA metabolic process [GO:0010586]; miRNA transcription [GO:0061614]; myoblast differentiation [GO:0045445]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of skeletal muscle cell differentiation [GO:2001014]; regulation of transcription by RNA polymerase II [GO:0006357]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin DNA binding [GO:0031490]; lncRNA binding [GO:0106222]; RNA helicase activity [GO:0003724]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0000380; GO:0000381; GO:0001837; GO:0003713; GO:0003724; GO:0005524; GO:0005634; GO:0005730; GO:0005829; GO:0006357; GO:0010467; GO:0010586; GO:0016607; GO:0016887; GO:0030520; GO:0030521; GO:0031490; GO:0045445; GO:0045944; GO:0061614; GO:0106222; GO:1990904; GO:2001014
GN012008	GN012008.1	Q8IWZ3	51.3	1983	2758	2542	1.19e-177	613	ANKH1_HUMAN	Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK)	Homo sapiens (Human)	innate immune response [GO:0045087]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005737; GO:0045087
GN012009	GN012009.1	Q13158	26.5	189	223	208	3.86e-11	63.5	FADD_HUMAN	FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)	Homo sapiens (Human)	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; behavioral response to cocaine [GO:0048148]; cellular response to mechanical stimulus [GO:0071260]; death-inducing signaling complex assembly [GO:0071550]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; kidney development [GO:0001822]; lymph node development [GO:0048535]; necroptotic signaling pathway [GO:0097527]; negative regulation of activation-induced cell death of T cells [GO:0070236]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [GO:2000454]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of proteolysis [GO:0045862]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; positive regulation of type II interferon production [GO:0032729]; regulation of necroptotic process [GO:0060544]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	caspase binding [GO:0089720]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; receptor serine/threonine kinase binding [GO:0033612]; signaling adaptor activity [GO:0035591]; tumor necrosis factor receptor superfamily binding [GO:0032813]	caspase complex [GO:0008303]; CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ripoptosome [GO:0097342]	GO:0001822; GO:0001916; GO:0002020; GO:0002821; GO:0005123; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006915; GO:0008303; GO:0008625; GO:0009898; GO:0030674; GO:0031264; GO:0031265; GO:0032729; GO:0032757; GO:0032760; GO:0032813; GO:0033077; GO:0033612; GO:0035591; GO:0035877; GO:0036462; GO:0042104; GO:0042802; GO:0043029; GO:0043065; GO:0043123; GO:0044297; GO:0044877; GO:0045089; GO:0045651; GO:0045862; GO:0045944; GO:0048148; GO:0048535; GO:0048536; GO:0048538; GO:0051607; GO:0060340; GO:0060544; GO:0070236; GO:0071260; GO:0071550; GO:0089720; GO:0097190; GO:0097191; GO:0097342; GO:0097527; GO:1900119; GO:2000454; GO:2001238
GN012010	GN012010.1	Q1EHB4	43.4	595	653	618	8.36e-166	491	SC5AC_HUMAN	Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12)	Homo sapiens (Human)	monocarboxylic acid transport [GO:0015718]; sodium ion transport [GO:0006814]	lactate transmembrane transporter activity [GO:0015129]; monocarboxylate:sodium symporter activity [GO:0140161]; organic acid:sodium symporter activity [GO:0005343]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	GO:0005343; GO:0005886; GO:0006814; GO:0015129; GO:0015718; GO:0016324; GO:0070062; GO:0140161
GN012011	GN012011.1	Q7KQL3	57.2	138	212	181	4.13e-49	161	ARF1_PLAF7	ADP-ribosylation factor 1 (PfARF1) (EC 3.6.5.2)	Plasmodium falciparum (isolate 3D7)	intracellular protein transport [GO:0006886]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi membrane [GO:0000139]	GO:0000139; GO:0003924; GO:0003925; GO:0005525; GO:0006886
GN012012	GN012012.1	Q5E9I6	40.5	131	227	181	3.17e-25	100	ARF3_BOVIN	ADP-ribosylation factor 3	Bos taurus (Bovine)	intracellular protein transport [GO:0006886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0003924; GO:0005525; GO:0005794; GO:0005886; GO:0006886; GO:0048471
GN012013	GN012013.1	P36397	56.2	146	212	181	7.38e-55	176	ARF1_ARATH	ADP-ribosylation factor 1 (AtARF1) (EC 3.6.5.2) (Protein BFA-VISUALIZED EXOCYTIC TRAFFICKING DEFECTIVE 1)	Arabidopsis thaliana (Mouse-ear cress)	intracellular protein transport [GO:0006886]; regulation of auxin metabolic process [GO:0090354]; response to brefeldin A [GO:0031001]; vesicle-mediated transport to the plasma membrane [GO:0098876]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; mRNA binding [GO:0003729]; phospholipase activator activity [GO:0016004]	cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802]	GO:0003729; GO:0003924; GO:0003925; GO:0005525; GO:0005768; GO:0005769; GO:0005794; GO:0005802; GO:0005829; GO:0006886; GO:0016004; GO:0031001; GO:0090354; GO:0098876
GN012014	GN012014.1	Q4GZT3	52.7	747	849	970	1.51e-252	733	PKD2_BOVIN	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Transient receptor potential cation channel subfamily P member 2)	Bos taurus (Bovine)	calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to calcium ion [GO:0071277]; cellular response to fluid shear stress [GO:0071498]; chordate embryonic development [GO:0043009]; detection of mechanical stimulus [GO:0050982]; determination of left/right symmetry [GO:0007368]; embryonic organ development [GO:0048568]; heart development [GO:0007507]; kidney development [GO:0001822]; liver development [GO:0001889]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]; release of sequestered calcium ion into cytosol [GO:0051209]; renal tubule morphogenesis [GO:0061333]; sodium ion transport [GO:0006814]; transmembrane transport [GO:0055085]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; monoatomic cation channel activity [GO:0005261]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; signaling receptor binding [GO:0005102]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated sodium channel activity [GO:0005248]	basal cortex [GO:0045180]; basolateral plasma membrane [GO:0016323]; cation channel complex [GO:0034703]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; migrasome [GO:0140494]; mitotic spindle [GO:0072686]; plasma membrane [GO:0005886]; polycystin complex [GO:0002133]; vesicle [GO:0031982]	GO:0001822; GO:0001889; GO:0002133; GO:0005102; GO:0005245; GO:0005248; GO:0005261; GO:0005262; GO:0005267; GO:0005509; GO:0005783; GO:0005789; GO:0005794; GO:0005886; GO:0005929; GO:0006813; GO:0006814; GO:0006816; GO:0007166; GO:0007368; GO:0007507; GO:0015271; GO:0016020; GO:0016323; GO:0030659; GO:0031982; GO:0034703; GO:0036064; GO:0043009; GO:0045180; GO:0045429; GO:0048568; GO:0050982; GO:0051209; GO:0051262; GO:0051290; GO:0055085; GO:0060170; GO:0061333; GO:0070062; GO:0070588; GO:0071277; GO:0071498; GO:0071805; GO:0072686; GO:0140494
GN012015	GN012015.1	P00761	35.4	189	194	231	1.45e-36	130	TRYP_PIG	Trypsin (EC 3.4.21.4)	Sus scrofa (Pig)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]	GO:0004252; GO:0005576; GO:0006508
GN012017	GN012017.1	Q8IZQ1	50.5	3667	3541	3526	0.0	3387	WDFY3_HUMAN	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy)	Homo sapiens (Human)	aggrephagy [GO:0035973]	1-phosphatidylinositol binding [GO:0005545]; metal ion binding [GO:0046872]	autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; perikaryon [GO:0043204]; PML body [GO:0016605]	GO:0000421; GO:0005545; GO:0005635; GO:0005737; GO:0005776; GO:0005829; GO:0016020; GO:0016234; GO:0016605; GO:0030424; GO:0031965; GO:0035973; GO:0043204; GO:0046872
GN012019	GN012019.1	Q5ZJA3	28.8	448	444	456	1.12e-29	123	CDR2_CHICK	Cerebellar degeneration-related protein 2	Gallus gallus (Chicken)			cytoplasm [GO:0005737]	GO:0005737
GN012021	GN012021.1	Q24423	36.4	258	495	537	5.08e-31	129	NOC_DROME	Zinc finger protein Noc (Zinc finger protein NocA)	Drosophila melanogaster (Fruit fly)	brain development [GO:0007420]; compound eye photoreceptor fate commitment [GO:0001752]; eye-antennal disc development [GO:0035214]; leg disc development [GO:0035218]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; ocellus development [GO:0008056]; open tracheal system development [GO:0007424]; terminal branching, open tracheal system [GO:0007430]; wing disc development [GO:0035220]		nucleus [GO:0005634]	GO:0001752; GO:0005634; GO:0007420; GO:0007424; GO:0007430; GO:0008056; GO:0010629; GO:0035214; GO:0035218; GO:0035220; GO:0045892
GN012022	GN012022.1	Q24423	30.7	574	487	537	2.11e-32	133	NOC_DROME	Zinc finger protein Noc (Zinc finger protein NocA)	Drosophila melanogaster (Fruit fly)	brain development [GO:0007420]; compound eye photoreceptor fate commitment [GO:0001752]; eye-antennal disc development [GO:0035214]; leg disc development [GO:0035218]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; ocellus development [GO:0008056]; open tracheal system development [GO:0007424]; terminal branching, open tracheal system [GO:0007430]; wing disc development [GO:0035220]		nucleus [GO:0005634]	GO:0001752; GO:0005634; GO:0007420; GO:0007424; GO:0007430; GO:0008056; GO:0010629; GO:0035214; GO:0035218; GO:0035220; GO:0045892
GN012028	GN012028.1	Q8BS45	79.7	553	554	554	0.0	919	IFT56_MOUSE	Intraflagellar transport protein 56 (Protein hop-sterile) (Tetratricopeptide repeat protein 26) (TPR repeat protein 26)	Mus musculus (Mouse)	axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium assembly [GO:0035735]; manchette assembly [GO:1905198]; photoreceptor cell differentiation [GO:0046530]; photoreceptor cell morphogenesis [GO:0008594]; protein localization to cilium [GO:0061512]; smoothened signaling pathway [GO:0007224]; spermatid development [GO:0007286]	intraciliary transport particle B binding [GO:0120170]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]; intraciliary transport particle B [GO:0030992]	GO:0005813; GO:0005929; GO:0007224; GO:0007286; GO:0008594; GO:0030991; GO:0030992; GO:0035082; GO:0035720; GO:0035735; GO:0036064; GO:0042073; GO:0046530; GO:0060271; GO:0061512; GO:0097546; GO:0120170; GO:1905198
GN012031	GN012031.1	Q6P1E7	39.1	422	419	537	1.20e-80	261	PRIPO_MOUSE	DNA-directed primase/polymerase protein (EC 2.7.7.102) (EC 2.7.7.7)	Mus musculus (Mouse)	DNA replication, synthesis of primer [GO:0006269]; error-prone translesion synthesis [GO:0042276]; mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; R-loop processing [GO:0062176]; replication fork processing [GO:0031297]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]	chromatin binding [GO:0003682]; DNA polymerase activity [GO:0034061]; DNA-directed DNA polymerase activity [GO:0003887]; DNA-directed RNA polymerase activity [GO:0003899]; manganese ion binding [GO:0030145]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0003682; GO:0003887; GO:0003899; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005759; GO:0006264; GO:0006269; GO:0008270; GO:0009411; GO:0019985; GO:0030145; GO:0031297; GO:0034061; GO:0042276; GO:0043504; GO:0062176
GN012032	GN012032.1	A1ZA47	38.8	85	159	2194	6.33e-14	71.6	ZASP_DROME	PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein)	Drosophila melanogaster (Fruit fly)	actin cytoskeleton organization [GO:0030036]; muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; regulation of cell-matrix adhesion [GO:0001952]	actin binding [GO:0003779]; actinin binding [GO:0042805]; muscle alpha-actinin binding [GO:0051371]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; basolateral plasma membrane [GO:0016323]; cell leading edge [GO:0031252]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; muscle tendon junction [GO:0005927]; stress fiber [GO:0001725]; Z disc [GO:0030018]; zonula adherens [GO:0005915]	GO:0001725; GO:0001952; GO:0003779; GO:0005912; GO:0005915; GO:0005925; GO:0005927; GO:0015629; GO:0016323; GO:0030018; GO:0030036; GO:0030239; GO:0031252; GO:0031941; GO:0042805; GO:0045177; GO:0045178; GO:0051371; GO:0061061
GN012034	GN012034.1	Q96MU7	45.2	396	643	727	1.75e-78	267	YTDC1_HUMAN	YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)	Homo sapiens (Human)	brown fat cell differentiation [GO:0050873]; dosage compensation by inactivation of X chromosome [GO:0009048]; mRNA export from nucleus [GO:0006406]; mRNA splice site recognition [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]	molecular sequestering activity [GO:0140313]; N6-methyladenosine-containing RNA reader activity [GO:1990247]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000381; GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0006376; GO:0006406; GO:0009048; GO:0010608; GO:0016607; GO:0048024; GO:0050873; GO:0140313; GO:1990247
GN012035	GN012035.1	Q28GD5	59.8	112	305	362	9.74e-33	127	SOX7_XENTR	Transcription factor Sox-7	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cell differentiation [GO:0030154]; endoderm formation [GO:0001706]; heart development [GO:0007507]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephros development [GO:0048793]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]	GO:0000976; GO:0000978; GO:0001228; GO:0001706; GO:0005634; GO:0007507; GO:0030154; GO:0043565; GO:0045944; GO:0048793
GN012036	GN012036.1	Q9BHM6	44.0	398	405	399	3.17e-125	370	OCDH_PECMA	Octopine dehydrogenase (OcDH) (EC 1.5.1.11)	Pecten maximus (King scallop) (Pilgrim's clam)		D-octopine dehydrogenase activity [GO:0047830]		GO:0047830
GN012037	GN012037.1	Q96MH6	46.2	171	213	324	3.81e-52	173	DIESL_HUMAN	DGAT1/2-independent enzyme synthesizing storage lipids (DIESL) (EC 2.3.1.-) (2-acylglycerol/1,2-diacylglycerol O-acyltransferase) (Monoacylglycerol/Diacylglycerol O-acyltransferase) (MGAT/DGAT) (EC 2.3.1.20, EC 2.3.1.22) (Transmembrane protein 68)	Homo sapiens (Human)	triglyceride biosynthetic process [GO:0019432]	2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]; phospholipid:diacylglycerol acyltransferase activity [GO:0046027]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0003846; GO:0004144; GO:0005789; GO:0016020; GO:0019432; GO:0046027
GN012038	GN012038.1	Q8BXQ6	32.4	865	788	823	2.14e-125	398	AMPO_MOUSE	Aminopeptidase O (AP-O) (EC 3.4.11.-)	Mus musculus (Mouse)		metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	GO:0005730; GO:0005737; GO:0008270; GO:0070006
GN012039	GN012039.1	Q3E906	33.3	405	428	450	1.69e-69	229	CD205_ARATH	Cell division cycle 20.5, cofactor of APC complex (AtCDC20.5)	Arabidopsis thaliana (Mouse-ear cress)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]; protein ubiquitination [GO:0016567]	anaphase-promoting complex binding [GO:0010997]; kinase binding [GO:0019900]; ubiquitin ligase activator activity [GO:1990757]	anaphase-promoting complex [GO:0005680]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; nucleus [GO:0005634]	GO:0005634; GO:0005680; GO:0010997; GO:0016567; GO:0019900; GO:0031145; GO:0080008; GO:1905786; GO:1990757
GN012040	GN012040.1	Q8N6D5	50.7	73	310	301	5.30e-13	71.6	ANR29_HUMAN	Ankyrin repeat domain-containing protein 29	Homo sapiens (Human)				
GN012041	GN012041.1	Q9UPV7	29.8	265	371	400	7.90e-26	110	PHF24_HUMAN	PHD finger protein 24	Homo sapiens (Human)		transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; synaptic vesicle membrane [GO:0030672]	GO:0003714; GO:0005634; GO:0005737; GO:0030672; GO:0098978
GN012042	GN012042.1	Q9UPV7	30.1	266	318	400	4.78e-24	104	PHF24_HUMAN	PHD finger protein 24	Homo sapiens (Human)		transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; synaptic vesicle membrane [GO:0030672]	GO:0003714; GO:0005634; GO:0005737; GO:0030672; GO:0098978
GN012044	GN012044.1	Q6DCF6	38.1	381	689	620	2.12e-73	252	EFCB7_XENLA	EF-hand calcium-binding domain-containing protein 7	Xenopus laevis (African clawed frog)	positive regulation of protein localization to ciliary membrane [GO:1903569]	calcium ion binding [GO:0005509]	ciliary membrane [GO:0060170]; plasma membrane protein complex [GO:0098797]	GO:0005509; GO:0060170; GO:0098797; GO:1903569
GN012053	GN012053.1	O60290	22.4	437	421	1169	3.25e-14	78.6	ZN862_HUMAN	Zinc finger protein 862	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	protein dimerization activity [GO:0046983]	nucleus [GO:0005634]	GO:0005634; GO:0006355; GO:0046983
GN012060	GN012060.1	O08605	55.7	395	489	427	1.39e-147	431	MKNK1_MOUSE	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1)	Mus musculus (Mouse)	extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of translational initiation [GO:0006446]; response to salt stress [GO:0009651]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	nucleoplasm [GO:0005654]	GO:0004674; GO:0005524; GO:0005654; GO:0006446; GO:0006468; GO:0009651; GO:0018105; GO:0035556; GO:0097192; GO:0106310
GN012062	GN012062.1	Q8K4R9	43.1	195	1286	808	2.28e-34	146	DLGP5_MOUSE	Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein homolog) (HURP)	Mus musculus (Mouse)	centrosome localization [GO:0051642]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic spindle organization [GO:0007052]; regulation of mitotic cell cycle [GO:0007346]; signaling [GO:0023052]	microtubule binding [GO:0008017]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616]	GO:0005634; GO:0005737; GO:0005829; GO:0007052; GO:0007059; GO:0007346; GO:0008017; GO:0023052; GO:0031616; GO:0051382; GO:0051642; GO:0072686
GN012063	GN012063.1	P27657	41.1	477	501	465	1.50e-113	346	LIPP_RAT	Pancreatic triacylglycerol lipase (PL) (Pancreatic lipase) (EC 3.1.1.3)	Rattus norvegicus (Rat)	cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; positive regulation of triglyceride lipase activity [GO:0061365]; post-embryonic development [GO:0009791]; response to lipid [GO:0033993]; response to peptide hormone [GO:0043434]; retinoid metabolic process [GO:0001523]; triglyceride catabolic process [GO:0019433]	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; glycerophospholipid phospholipase A1 activity [GO:0008970]; lipase activity [GO:0016298]; lipoprotein lipase activity [GO:0004465]; retinyl-palmitate esterase activity [GO:0050253]; triacylglycerol lipase activity [GO:0004806]	extracellular region [GO:0005576]	GO:0001523; GO:0004465; GO:0004806; GO:0005576; GO:0006629; GO:0006633; GO:0008970; GO:0009791; GO:0016298; GO:0019433; GO:0030299; GO:0033993; GO:0034375; GO:0042632; GO:0043434; GO:0047376; GO:0050253; GO:0061365
GN012064	GN012064.1	A2VEC9	24.6	1860	1573	5150	5.77e-124	435	SSPO_HUMAN	SCO-spondin (SCO-spondin pseudogene)	Homo sapiens (Human)		extracellular matrix structural constituent [GO:0005201]; peptidase inhibitor activity [GO:0030414]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005201; GO:0005576; GO:0030414; GO:0031012
GN012067	GN012067.1	Q9UK41	69.6	184	185	221	2.49e-84	251	VPS28_HUMAN	Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28)	Homo sapiens (Human)	macroautophagy [GO:0016236]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]	ubiquitin binding [GO:0043130]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]	GO:0000813; GO:0005737; GO:0005768; GO:0005769; GO:0005829; GO:0005886; GO:0010008; GO:0016236; GO:0031397; GO:0031902; GO:0036258; GO:0039702; GO:0043130; GO:0043162; GO:0043328; GO:0045732; GO:0070062; GO:0090148; GO:2000397
GN012068	GN012068.1	Q5M7F8	53.7	121	180	155	2.42e-44	147	CM2CA_XENLA	Ciliary microtubule inner protein 2C	Xenopus laevis (African clawed frog)			axonemal microtubule [GO:0005879]	GO:0005879
GN012069	GN012069.1	Q5ZL21	51.9	231	278	238	2.45e-88	265	MMAC_CHICK	Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC)	Gallus gallus (Chicken)	cobalamin metabolic process [GO:0009235]; demethylation [GO:0070988]; glutathione metabolic process [GO:0006749]	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity [GO:0033787]; demethylase activity [GO:0032451]; FAD binding [GO:0071949]; glutathione binding [GO:0043295]; oxidoreductase activity [GO:0016491]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0006749; GO:0009235; GO:0016491; GO:0032451; GO:0033787; GO:0043295; GO:0070988; GO:0071949
GN012070	GN012070.1	Q7ZYB4	30.5	407	456	463	4.16e-38	147	PAIP1_XENLA	Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Paip1 protein) (Poly(A)-binding protein-interacting protein 1) (XlPaip1)	Xenopus laevis (African clawed frog)	regulation of translational initiation [GO:0006446]	RNA binding [GO:0003723]; translation activator activity [GO:0008494]	cytoplasm [GO:0005737]	GO:0003723; GO:0005737; GO:0006446; GO:0008494
GN012071	GN012071.1	Q3TKT4	69.6	936	1016	1613	0.0	1249	SMCA4_MOUSE	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1)	Mus musculus (Mouse)	aorta development [GO:0035904]; aortic smooth muscle cell differentiation [GO:0035887]; blastocyst growth [GO:0001832]; blastocyst hatching [GO:0001835]; blood vessel development [GO:0001568]; cell morphogenesis [GO:0000902]; chromatin remodeling [GO:0006338]; coronary vasculature development [GO:0060976]; definitive erythrocyte differentiation [GO:0060318]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic organ morphogenesis [GO:0048562]; epidermis morphogenesis [GO:0048730]; extracellular matrix organization [GO:0030198]; forebrain development [GO:0030900]; gene expression [GO:0010467]; glial cell fate determination [GO:0007403]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; hindbrain development [GO:0030902]; host-mediated activation of viral transcription [GO:0043923]; in utero embryonic development [GO:0001701]; keratinocyte differentiation [GO:0030216]; lens fiber cell development [GO:0070307]; liver development [GO:0001889]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural retina development [GO:0003407]; neurogenesis [GO:0022008]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; oligodendrocyte development [GO:0014003]; outflow tract morphogenesis [GO:0003151]; pharyngeal arch artery morphogenesis [GO:0061626]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell size [GO:0045793]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of glucose mediated signaling pathway [GO:1902661]; positive regulation of macrophage fusion [GO:0034241]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of myelination [GO:0031643]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of cell migration [GO:0030334]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; stem cell population maintenance [GO:0019827]; transcription initiation-coupled chromatin remodeling [GO:0045815]; vasculogenesis [GO:0001570]; ventricular septum development [GO:0003281]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA polymerase binding [GO:0070182]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; nuclear androgen receptor binding [GO:0050681]; p53 binding [GO:0002039]; protein-containing complex binding [GO:0044877]; RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]	bBAF complex [GO:0140092]; chromatin [GO:0000785]; euchromatin [GO:0000791]; fibrillar center [GO:0001650]; GBAF complex [GO:0140288]; kinetochore [GO:0000776]; nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	GO:0000122; GO:0000776; GO:0000785; GO:0000791; GO:0000902; GO:0000977; GO:0000978; GO:0001164; GO:0001221; GO:0001568; GO:0001570; GO:0001650; GO:0001701; GO:0001832; GO:0001835; GO:0001889; GO:0002039; GO:0003151; GO:0003281; GO:0003407; GO:0003682; GO:0003713; GO:0003714; GO:0005524; GO:0005634; GO:0005654; GO:0005726; GO:0005730; GO:0006334; GO:0006337; GO:0006338; GO:0006357; GO:0007399; GO:0007403; GO:0007507; GO:0008094; GO:0008284; GO:0010467; GO:0014003; GO:0016363; GO:0016514; GO:0016586; GO:0016887; GO:0019827; GO:0022008; GO:0030071; GO:0030177; GO:0030198; GO:0030216; GO:0030308; GO:0030334; GO:0030900; GO:0030902; GO:0030957; GO:0031643; GO:0034241; GO:0035116; GO:0035887; GO:0035904; GO:0042393; GO:0042802; GO:0043066; GO:0043524; GO:0043923; GO:0044877; GO:0045582; GO:0045596; GO:0045597; GO:0045663; GO:0045793; GO:0045815; GO:0045892; GO:0045893; GO:0045944; GO:0048562; GO:0048730; GO:0050681; GO:0060318; GO:0060347; GO:0060766; GO:0060976; GO:0061626; GO:0070182; GO:0070307; GO:0070316; GO:0071564; GO:0071565; GO:0106222; GO:0120162; GO:0140092; GO:0140288; GO:0140658; GO:1901798; GO:1901838; GO:1902459; GO:1902661; GO:1902895; GO:1903427; GO:2000045; GO:2000781; GO:2000819
GN012072	GN012072.1	Q6DF94	32.3	409	781	793	1.10e-36	151	SPICE_XENLA	Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52)	Xenopus laevis (African clawed frog)	metaphase chromosome alignment [GO:0051310]; mitotic spindle assembly [GO:0090307]; regulation of centriole replication [GO:0046599]		centriole [GO:0005814]; centrosome [GO:0005813]; spindle [GO:0005819]	GO:0005813; GO:0005814; GO:0005819; GO:0046599; GO:0051310; GO:0090307
GN012073	GN012073.1	Q9WVG6	58.2	526	576	608	1.06e-199	574	CARM1_MOUSE	Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4)	Mus musculus (Mouse)	apoptotic process [GO:0006915]; endochondral bone morphogenesis [GO:0060350]; estrogen receptor signaling pathway [GO:0030520]; gene expression [GO:0010467]; negative regulation of dendrite development [GO:2000171]; nuclear receptor-mediated steroid hormone signaling pathway [GO:0030518]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of epithelial cell apoptotic process [GO:1904037]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to chromatin [GO:0071168]; protein methylation [GO:0006479]; regulation of DNA-templated transcription [GO:0006355]; regulation of growth plate cartilage chondrocyte proliferation [GO:0003420]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; replication fork reversal [GO:0071932]; response to cAMP [GO:0051591]	histone H3R17 methyltransferase activity [GO:0035642]; histone H3R2 methyltransferase activity [GO:0070611]; histone H3R26 methyltransferase activity [GO:0140903]; histone methyltransferase activity [GO:0042054]; protein methyltransferase activity [GO:0008276]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000976; GO:0003420; GO:0003713; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005829; GO:0006355; GO:0006479; GO:0006915; GO:0008276; GO:0008284; GO:0010467; GO:0016274; GO:0030518; GO:0030520; GO:0032991; GO:0033146; GO:0035242; GO:0035642; GO:0042054; GO:0043123; GO:0043596; GO:0045600; GO:0045944; GO:0051591; GO:0060350; GO:0070611; GO:0071168; GO:0071932; GO:0090575; GO:0140903; GO:1904037; GO:2000171
GN012074	GN012074.1	Q3T0E1	55.4	168	174	275	1.46e-65	204	EXOS3_BOVIN	Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40)	Bos taurus (Bovine)	CUT catabolic process [GO:0071034]; DNA deamination [GO:0045006]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; isotype switching [GO:0045190]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear-transcribed mRNA catabolic process [GO:0000956]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; TRAMP-dependent tRNA surveillance pathway [GO:0071038]; U4 snRNA 3'-end processing [GO:0034475]	RNA binding [GO:0003723]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0000176; GO:0000177; GO:0000178; GO:0000467; GO:0000791; GO:0000956; GO:0003723; GO:0005654; GO:0005730; GO:0005829; GO:0034475; GO:0045006; GO:0045190; GO:0071034; GO:0071035; GO:0071038; GO:0071051
GN012075	GN012075.1	Q8T3X9	66.9	130	128	130	1.15e-59	182	ISCA1_DROME	Iron-sulfur cluster assembly 1 homolog, mitochondrial (Lethal (1) G0136) (Putative magnetoreceptor subunit MagR)	Drosophila melanogaster (Fruit fly)	[4Fe-4S] cluster assembly [GO:0044572]; iron-sulfur cluster assembly [GO:0016226]; protein maturation [GO:0051604]; response to magnetism [GO:0071000]	2 iron, 2 sulfur cluster binding [GO:0051537]	cytoplasm [GO:0005737]; mitochondrial [4Fe-4S] assembly complex [GO:0120510]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005737; GO:0005739; GO:0005759; GO:0016226; GO:0044572; GO:0051537; GO:0051604; GO:0071000; GO:0120510
GN012077	GN012077.1	Q13233	33.4	1090	1153	1512	5.95e-132	441	M3K1_HUMAN	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)	Homo sapiens (Human)	cellular response to mechanical stimulus [GO:0071260]; Fc-epsilon receptor signaling pathway [GO:0038095]; MAPK cascade [GO:0000165]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; tight junction [GO:0070160]	GO:0000165; GO:0004672; GO:0004674; GO:0004709; GO:0005524; GO:0005829; GO:0006468; GO:0008270; GO:0019901; GO:0038095; GO:0061630; GO:0070160; GO:0071260; GO:0106310
GN012078	GN012078.1	Q62925	71.3	171	183	1493	2.68e-79	259	M3K1_RAT	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)	Rattus norvegicus (Rat)	apoptotic mitochondrial changes [GO:0008637]; camera-type eye development [GO:0043010]; cellular response to mechanical stimulus [GO:0071260]; epithelial cell morphogenesis [GO:0003382]; eyelid development in camera-type eye [GO:0061029]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; morphogenesis of an epithelial sheet [GO:0002011]; negative regulation of actin filament bundle assembly [GO:0032232]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of viral transcription [GO:0050434]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein polyubiquitination [GO:0000209]; regulation of cell migration [GO:0030334]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ubiquitin-dependent protein catabolic process [GO:0006511]; wound healing [GO:0042060]	ATP binding [GO:0005524]; cytoskeletal protein binding [GO:0008092]; JUN kinase binding [GO:0008432]; JUN kinase kinase kinase activity [GO:0004706]; MAP kinase kinase activity [GO:0004708]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase binding [GO:0051019]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; sphingolipid binding [GO:0046625]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	filamentous actin [GO:0031941]; membrane [GO:0016020]; tight junction [GO:0070160]	GO:0000165; GO:0000209; GO:0002011; GO:0003382; GO:0004672; GO:0004674; GO:0004706; GO:0004708; GO:0004709; GO:0004842; GO:0005524; GO:0006468; GO:0006511; GO:0007179; GO:0007254; GO:0008092; GO:0008270; GO:0008432; GO:0008637; GO:0016020; GO:0018105; GO:0019901; GO:0030334; GO:0030838; GO:0031434; GO:0031941; GO:0032232; GO:0042060; GO:0043010; GO:0043065; GO:0043406; GO:0043410; GO:0043507; GO:0044877; GO:0045893; GO:0045944; GO:0046330; GO:0046625; GO:0046777; GO:0050434; GO:0051019; GO:0061029; GO:0061630; GO:0070160; GO:0071260; GO:0090263; GO:0106310
GN012079	GN012079.1	Q8N4L8	28.8	243	391	307	5.11e-19	90.1	CCD24_HUMAN	Coiled-coil domain-containing protein 24	Homo sapiens (Human)				
GN012080	GN012080.1	Q7YU29	40.2	376	770	1051	3.83e-74	264	DMDE_DROME	Dystrophin, isoform E (Protein detached)	Drosophila melanogaster (Fruit fly)	establishment of cell polarity [GO:0030010]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; imaginal disc-derived wing vein specification [GO:0007474]; maintenance of presynaptic active zone structure [GO:0048790]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; neuromuscular synaptic transmission [GO:0007274]; regulation of neurotransmitter secretion [GO:0046928]; regulation of short-term neuronal synaptic plasticity [GO:0048172]	WW domain binding [GO:0050699]; zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; neuromuscular junction [GO:0031594]; sarcolemma [GO:0042383]; synapse [GO:0045202]	GO:0005737; GO:0005856; GO:0005938; GO:0007274; GO:0007474; GO:0007517; GO:0008270; GO:0008586; GO:0016010; GO:0030010; GO:0031594; GO:0042383; GO:0045202; GO:0046716; GO:0046928; GO:0048172; GO:0048790; GO:0050699
GN012081	GN012081.1	Q27350	43.8	64	66	416	2.11e-10	57.4	SO_DROME	Protein sine oculis	Drosophila melanogaster (Fruit fly)	Bolwig's organ morphogenesis [GO:0001746]; circadian rhythm [GO:0007623]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; entrainment of circadian clock [GO:0009649]; glial cell migration [GO:0008347]; insect visual primordium formation [GO:0001744]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; ring gland development [GO:0035271]; spermatogenesis [GO:0007283]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000978; GO:0000981; GO:0001222; GO:0001223; GO:0001744; GO:0001745; GO:0001746; GO:0005634; GO:0005667; GO:0006357; GO:0007283; GO:0007623; GO:0008347; GO:0009649; GO:0035271; GO:0043565; GO:0045944; GO:0048749
GN012082	GN012082.1	Q9WYJ1	42.5	391	469	401	2.14e-96	299	TSAL_THEMA	L-threonine ammonia-lyase (EC 4.3.1.19) (L-serine ammonia-lyase) (EC 4.3.1.17) (Threonine dehydratase)	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	L-serine catabolic process [GO:0006565]; L-threonine catabolic process [GO:0006567]	L-serine ammonia-lyase activity [GO:0003941]; pyridoxal phosphate binding [GO:0030170]; threonine deaminase activity [GO:0004794]		GO:0003941; GO:0004794; GO:0006565; GO:0006567; GO:0030170
GN012084	GN012084.1	Q2KIR8	64.6	277	297	373	9.20e-135	389	TDH_BOVIN	L-threonine 3-dehydrogenase, mitochondrial (EC 1.1.1.103)	Bos taurus (Bovine)	L-threonine catabolic process [GO:0006567]	identical protein binding [GO:0042802]; L-threonine 3-dehydrogenase activity [GO:0008743]	mitochondrion [GO:0005739]	GO:0005739; GO:0006567; GO:0008743; GO:0042802
GN012087	GN012087.1	Q2TA24	66.2	139	145	205	5.68e-52	166	VATO_BOVIN	V-type proton ATPase 21 kDa proteolipid subunit c'' (V-ATPase 21 kDa proteolipid subunit c'') (Vacuolar proton pump 21 kDa proteolipid subunit c'')	Bos taurus (Bovine)	pH reduction [GO:0045851]; proton transmembrane transport [GO:1902600]	proton-transporting ATPase activity, rotational mechanism [GO:0046961]	clathrin-coated vesicle membrane [GO:0030665]; endosome [GO:0005768]; membrane [GO:0016020]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	GO:0000220; GO:0005768; GO:0016020; GO:0030665; GO:0045851; GO:0046961; GO:1902600
GN012088	GN012088.1	Q9H553	55.4	401	426	416	2.88e-143	417	ALG2_HUMAN	Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (Asparagine-linked glycosylation protein 2 homolog) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase)	Homo sapiens (Human)	dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; glycoprotein biosynthetic process [GO:0009101]; protein N-linked glycosylation [GO:0006487]	alpha-1,3-mannosyltransferase activity [GO:0000033]; GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity [GO:0004378]; GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity [GO:0102704]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0000033; GO:0004378; GO:0005789; GO:0006487; GO:0006488; GO:0009101; GO:0012505; GO:0016020; GO:0098554; GO:0102704
GN012089	GN012089.1	Q6GPP0	53.8	619	616	622	4.31e-218	623	WDR70_XENLA	WD repeat-containing protein 70	Xenopus laevis (African clawed frog)			nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0005634; GO:0035861
GN012090	GN012090.1	Q90YI8	74.2	62	220	371	2.32e-23	99.4	TAL1_TAKRU	T-cell acute lymphocytic leukemia protein 1 (TAL-1) (FrSCL) (Stem cell protein)	Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)	angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; definitive hemopoiesis [GO:0060216]; endocardium formation [GO:0060214]; erythrocyte differentiation [GO:0030218]; hemangioblast cell differentiation [GO:0060217]; hematopoietic stem cell differentiation [GO:0060218]; myeloid cell differentiation [GO:0030099]; primitive hemopoiesis [GO:0060215]; vasculogenesis [GO:0001570]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001525; GO:0001570; GO:0003677; GO:0005634; GO:0030099; GO:0030218; GO:0046983; GO:0048844; GO:0060214; GO:0060215; GO:0060216; GO:0060217; GO:0060218
GN012091	GN012091.1	Q9R1K5	86.2	275	276	493	1.66e-174	493	FZR1_MOUSE	Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog)	Mus musculus (Mouse)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; DNA synthesis involved in mitotic DNA replication [GO:1904860]; lens fiber cell differentiation [GO:0070306]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cellular senescence [GO:2000773]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; regulation of meiotic nuclear division [GO:0040020]; thymidine biosynthetic process [GO:0046105]	anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	anaphase-promoting complex [GO:0005680]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005680; GO:0007095; GO:0008284; GO:0010997; GO:0016567; GO:0030163; GO:0031145; GO:0031965; GO:0040020; GO:0046105; GO:0070306; GO:1904668; GO:1904860; GO:1905786; GO:1990756; GO:1990757; GO:2000773
GN012092	GN012092.1	Q66KE8	38.0	479	919	559	6.48e-84	283	CCD78_XENLA	Coiled-coil domain-containing protein 78 (xCCDC78)	Xenopus laevis (African clawed frog)	de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]		centriole [GO:0005814]; cytoplasm [GO:0005737]; deuterosome [GO:0098536]	GO:0005737; GO:0005814; GO:0098535; GO:0098536
GN012093	GN012093.1	Q2KJ81	83.7	423	422	423	3.65e-261	716	AP1M1_BOVIN	AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin)	Bos taurus (Bovine)	Golgi to vacuole transport [GO:0006896]; intracellular protein transport [GO:0006886]	clathrin-cargo adaptor activity [GO:0035615]	clathrin adaptor complex [GO:0030131]; clathrin-coated vesicle membrane [GO:0030665]; trans-Golgi network [GO:0005802]	GO:0005802; GO:0006886; GO:0006896; GO:0030131; GO:0030665; GO:0035615
GN012095	GN012095.1	P09057	54.0	398	467	461	7.10e-148	432	DCOR_RAT	Ornithine decarboxylase (ODC) (EC 4.1.1.17)	Rattus norvegicus (Rat)	kidney development [GO:0001822]; polyamine metabolic process [GO:0006595]; positive regulation of cell population proliferation [GO:0008284]; putrescine biosynthetic process [GO:0009446]; regulation of protein catabolic process [GO:0042176]; response to virus [GO:0009615]; spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597]	ornithine decarboxylase activator activity [GO:0042978]; ornithine decarboxylase activity [GO:0004586]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]	GO:0001822; GO:0004586; GO:0005737; GO:0005829; GO:0006595; GO:0006597; GO:0008284; GO:0008295; GO:0009446; GO:0009615; GO:0042176; GO:0042803; GO:0042978; GO:0048471
GN012096	GN012096.1	F4JL28	47.9	48	241	234	7.92e-09	57.8	EBS_ARATH	Chromatin remodeling protein EBS (Protein EARLY BOLTING IN SHORT DAYS)	Arabidopsis thaliana (Mouse-ear cress)	negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of long-day photoperiodism, flowering [GO:0048579]; post-embryonic development [GO:0009791]; regulation of photoperiodism, flowering [GO:2000028]; seed germination [GO:0009845]	chromatin binding [GO:0003682]; histone H3K4me3 reader activity [GO:0140002]; molecular function inhibitor activity [GO:0140678]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]	GO:0000976; GO:0003682; GO:0005634; GO:0009791; GO:0009845; GO:0045814; GO:0048579; GO:0140002; GO:0140678; GO:2000028
GN012097	GN012097.1	Q5D016	61.5	91	104	122	6.60e-30	106	PFD1_DANRE	Prefoldin subunit 1	Danio rerio (Zebrafish) (Brachydanio rerio)		protein folding chaperone [GO:0044183]	cytoplasm [GO:0005737]; prefoldin complex [GO:0016272]	GO:0005737; GO:0016272; GO:0044183
GN012099	GN012099.1	Q4FZQ6	58.0	143	252	312	2.51e-42	149	PR38A_XENLA	Pre-mRNA-splicing factor 38A	Xenopus laevis (African clawed frog)	mRNA splicing, via spliceosome [GO:0000398]		nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]	GO:0000398; GO:0005634; GO:0071005; GO:0071011
GN012100	GN012100.1	Q5UQ88	27.7	716	849	1441	1.40e-73	266	UBC3_MIMIV	Probable ubiquitin-conjugating enzyme E2 R521 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R521) (Ubiquitin carrier protein) (Ubiquitin-protein ligase)	Acanthamoeba polyphaga mimivirus (APMV)	DNA protection [GO:0042262]; protein ubiquitination [GO:0016567]	ubiquitin conjugating enzyme activity [GO:0061631]	membrane [GO:0016020]	GO:0016020; GO:0016567; GO:0042262; GO:0061631
GN012101	GN012101.1	Q5XHH9	49.2	573	617	586	3.15e-191	553	TT39B_XENLA	Tetratricopeptide repeat protein 39B (TPR repeat protein 39B)	Xenopus laevis (African clawed frog)				
GN012102	GN012102.1	Q922Q5	66.0	303	380	369	1.78e-138	402	S35B3_MOUSE	Adenosine 3'-phospho 5'-phosphosulfate transporter 2 (Solute carrier family 35 member B3)	Mus musculus (Mouse)	3'-phosphoadenosine 5'-phosphosulfate transport [GO:0046963]; 5'-adenylyl sulfate transmembrane transport [GO:1902558]; peptidyl-tyrosine sulfation [GO:0006478]	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964]	Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0005739; GO:0005802; GO:0006478; GO:0046963; GO:0046964; GO:1902558
GN012103	GN012103.1	F1RB95	32.2	426	568	459	5.64e-60	209	RNF14_DANRE	E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (RING finger protein 14)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein ubiquitination [GO:0016567]; protein-RNA covalent cross-linking repair [GO:0160127]; regulation of canonical Wnt signaling pathway [GO:0060828]; rescue of stalled cytosolic ribosome [GO:0072344]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005634; GO:0005737; GO:0008270; GO:0016567; GO:0031624; GO:0060828; GO:0061630; GO:0072344; GO:0160127
GN012104	GN012104.1	Q09477	41.2	114	424	372	5.81e-25	108	DPFF1_CAEEL	Zinc finger protein dpff-1	Caenorhabditis elegans	apoptotic process [GO:0006915]; chromatin remodeling [GO:0006338]; meiotic cell cycle [GO:0051321]; positive regulation of double-strand break repair [GO:2000781]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; response to heat [GO:0009408]	transcription coregulator activity [GO:0003712]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003712; GO:0005634; GO:0005737; GO:0006338; GO:0006355; GO:0006915; GO:0009408; GO:0030071; GO:0051321; GO:2000045; GO:2000781; GO:2000819
GN012105	GN012105.1	Q90805	71.1	419	441	735	9.00e-208	594	CNG1_CHICK	Cyclic nucleotide-gated channel cone photoreceptor subunit alpha (CNG channel 1) (CNG-1) (CNG1)	Gallus gallus (Chicken)	monoatomic cation transmembrane transport [GO:0098655]; retina development in camera-type eye [GO:0060041]	cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]	intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; plasma membrane [GO:0005886]	GO:0005222; GO:0005223; GO:0005886; GO:0017071; GO:0030553; GO:0060041; GO:0098655
GN012108	GN012108.1	A6H7C2	42.0	176	190	373	9.40e-31	118	PEX3_BOVIN	Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3)	Bos taurus (Bovine)	protein import into peroxisome membrane [GO:0045046]	protein-macromolecule adaptor activity [GO:0030674]	peroxisomal membrane [GO:0005778]	GO:0005778; GO:0030674; GO:0045046
GN012109	GN012109.1	Q9BRS2	59.1	396	486	568	2.70e-158	464	RIOK1_HUMAN	Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.1.-) (RIO kinase 1)	Homo sapiens (Human)	maturation of SSU-rRNA [GO:0030490]; positive regulation of rRNA processing [GO:2000234]; ribosomal small subunit biogenesis [GO:0042274]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; methylosome [GO:0034709]; methyltransferase complex [GO:0034708]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]	GO:0004674; GO:0005524; GO:0005654; GO:0005737; GO:0005829; GO:0016887; GO:0030490; GO:0030688; GO:0034708; GO:0034709; GO:0042274; GO:0106310; GO:2000234
GN012110	GN012110.1	Q9NY47	23.0	1034	1048	1150	9.56e-47	186	CA2D2_HUMAN	Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]	Homo sapiens (Human)		voltage-gated calcium channel activity [GO:0005245]	plasma membrane [GO:0005886]; voltage-gated calcium channel complex [GO:0005891]	GO:0005245; GO:0005886; GO:0005891
GN012111	GN012111.1	P32240	36.0	333	341	513	6.92e-57	195	PE2R4_MOUSE	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0000165; GO:0001818; GO:0001819; GO:0002792; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0008284; GO:0009624; GO:0010628; GO:0010840; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0071260; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1904496; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN012112	GN012112.1	Q9CRA8	50.0	208	214	235	9.51e-71	218	EXOS5_MOUSE	Exosome complex component RRP46 (Exosome component 5) (Ribosomal RNA-processing protein 46)	Mus musculus (Mouse)	defense response to virus [GO:0051607]; DNA deamination [GO:0045006]; mRNA catabolic process [GO:0006402]; nuclear mRNA surveillance [GO:0071028]; poly(A)-dependent snoRNA 3'-end processing [GO:0071051]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; U4 snRNA 3'-end processing [GO:0034475]	RNA binding [GO:0003723]	cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; euchromatin [GO:0000791]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000176; GO:0000177; GO:0000178; GO:0000791; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0006396; GO:0006401; GO:0006402; GO:0016075; GO:0034475; GO:0045006; GO:0051607; GO:0071028; GO:0071051; GO:0101019
GN012114	GN012114.1	P12276	48.6	2425	2401	2512	0.0	2199	FAS_CHICK	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]	Gallus gallus (Chicken)	fatty acid biosynthetic process [GO:0006633]; lactate metabolic process [GO:0006089]; positive regulation of appetite [GO:0032100]	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [GO:0019171]; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; [acyl-carrier-protein] S-acetyltransferase activity [GO:0004313]; [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; enoyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0141148]; fatty acid synthase activity [GO:0004312]; fatty acyl-[ACP] hydrolase activity [GO:0016297]; phosphopantetheine binding [GO:0031177]; single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]	GO:0003697; GO:0004312; GO:0004313; GO:0004314; GO:0004315; GO:0004316; GO:0005737; GO:0006089; GO:0006633; GO:0016297; GO:0019171; GO:0031177; GO:0032100; GO:0141148
GN012115	GN012115.1	Q9UKN7	30.1	768	974	3530	8.56e-70	258	MYO15_HUMAN	Unconventional myosin-XV (Unconventional myosin-15)	Homo sapiens (Human)	endocytosis [GO:0006897]; response to light stimulus [GO:0009416]; sensory perception of sound [GO:0007605]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; cytoskeletal motor activity [GO:0003774]	actin cytoskeleton [GO:0015629]; actin-based cell projection [GO:0098858]; extracellular exosome [GO:0070062]; myosin complex [GO:0016459]; stereocilium [GO:0032420]	GO:0003774; GO:0005524; GO:0006897; GO:0007605; GO:0009416; GO:0015629; GO:0016459; GO:0032420; GO:0051015; GO:0070062; GO:0098858
GN012116	GN012116.1	Q5RBD5	71.1	398	420	423	2.42e-205	575	IVD_PONAB	Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4) (Butyryl-CoA dehydrogenase) (EC 1.3.8.1)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	branched-chain amino acid catabolic process [GO:0009083]; L-leucine catabolic process [GO:0006552]	3-methylbutanoyl-CoA dehydrogenase activity [GO:0008470]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; medium-chain fatty acyl-CoA dehydrogenase activity [GO:0070991]	mitochondrial matrix [GO:0005759]	GO:0005759; GO:0006552; GO:0008470; GO:0009083; GO:0042802; GO:0050660; GO:0070991
GN012117	GN012117.1	Q6DJF8	52.3	218	234	234	1.43e-82	249	MET23_XENLA	Histone-arginine methyltransferase METTL23 (EC 2.1.1.319) (Methyltransferase-like protein 23)	Xenopus laevis (African clawed frog)	epigenetic regulation of gene expression [GO:0040029]	histone H3R17 methyltransferase activity [GO:0035642]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0035242; GO:0035642; GO:0040029
GN012118	GN012118.1	Q9KPS0	49.0	100	110	106	6.07e-29	103	BOLA_VIBCH	DNA-binding transcriptional regulator BolA	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	DNA-templated transcription [GO:0006351]		cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]	GO:0005829; GO:0006351; GO:1990229
GN012119	GN012119.1	Q94AM1	26.3	707	717	791	8.09e-55	204	OOPDA_ARATH	Organellar oligopeptidase A, chloroplastic/mitochondrial (AtOOP) (EC 3.4.24.70) (Thimet metalloendopeptidase 1) (Zincin-like metalloproteases family protein 1)	Arabidopsis thaliana (Mouse-ear cress)	proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]	chloroplast [GO:0009507]; chloroplast stroma [GO:0009570]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plastid [GO:0009536]	GO:0004222; GO:0005739; GO:0005759; GO:0006508; GO:0009507; GO:0009536; GO:0009570
GN012120	GN012120.1	Q29S22	81.3	416	437	457	9.12e-237	657	DDX47_BOVIN	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47)	Bos taurus (Bovine)	extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0005524; GO:0005634; GO:0005730; GO:0006364; GO:0008380; GO:0008625; GO:0016887
GN012123	GN012123.1	Q9UKB3	35.8	201	171	198	8.54e-39	134	DJC12_HUMAN	DnaJ homolog subfamily C member 12 (J domain-containing protein 1)	Homo sapiens (Human)			cytoplasm [GO:0005737]	GO:0005737
GN012124	GN012124.1	A0A0G2JZ79	49.1	552	729	741	6.75e-156	473	SIR1_RAT	NAD-dependent protein deacetylase sirtuin-1 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]	Rattus norvegicus (Rat)	angiogenesis [GO:0001525]; behavioral response to starvation [GO:0042595]; cardiac muscle cell apoptotic process [GO:0010659]; cellular response to amyloid-beta [GO:1904646]; cellular response to antibiotic [GO:0071236]; cellular response to curcumin [GO:1904644]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to resveratrol [GO:1904639]; cellular response to rotenone [GO:1904648]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin B3 [GO:0071303]; cholesterol homeostasis [GO:0042632]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; DNA repair-dependent chromatin remodeling [GO:0140861]; DNA synthesis involved in DNA repair [GO:0000731]; endoplasmic reticulum unfolded protein response [GO:0030968]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; heterochromatin formation [GO:0031507]; intracellular glucose homeostasis [GO:0001678]; intracellular triglyceride homeostasis [GO:0035356]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; leptin-mediated signaling pathway [GO:0033210]; macrophage differentiation [GO:0030225]; maintenance of nucleus location [GO:0051658]; mitochondrion organization [GO:0007005]; negative regulation of adipose tissue development [GO:1904178]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902424]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of cell cycle [GO:0045786]; negative regulation of cellular response to testosterone stimulus [GO:2000655]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of gene expression [GO:0010629]; negative regulation of growth hormone secretion [GO:0060125]; negative regulation of hippo signaling [GO:0035331]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of phosphorylation [GO:0042326]; negative regulation of prostaglandin biosynthetic process [GO:0031393]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of triglyceride biosynthetic process [GO:0010868]; negative regulation of tumor necrosis factor production [GO:0032720]; neuron apoptotic process [GO:0051402]; ovulation from ovarian follicle [GO:0001542]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cellular senescence [GO:2000774]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of granulosa cell apoptotic process [GO:1904710]; positive regulation of heart rate [GO:0010460]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of macroautophagy [GO:0016239]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein deacetylation [GO:0090312]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of skeletal muscle cell proliferation [GO:0014858]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of thyroid-stimulating hormone secretion [GO:2000614]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride catabolic process [GO:0010898]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deacetylation [GO:0006476]; protein depropionylation [GO:0106230]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; rDNA heterochromatin formation [GO:0000183]; regulation of apoptotic process [GO:0042981]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of brown fat cell differentiation [GO:0090335]; regulation of cell population proliferation [GO:0042127]; regulation of centrosome duplication [GO:0010824]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid storage [GO:0010883]; regulation of mitotic cell cycle [GO:0007346]; regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358]; regulation of smooth muscle cell apoptotic process [GO:0034391]; regulation of transcription by glucose [GO:0046015]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; response to fluoride [GO:1902617]; response to hydrogen peroxide [GO:0042542]; response to insulin [GO:0032868]; response to kainic acid [GO:1904373]; response to leptin [GO:0044321]; response to mycotoxin [GO:0010046]; response to nutrient levels [GO:0031667]; response to oxidative stress [GO:0006979]; response to resveratrol [GO:1904638]; single strand break repair [GO:0000012]; spermatogenesis [GO:0007283]; stress-induced premature senescence [GO:0090400]; subtelomeric heterochromatin formation [GO:0031509]; transforming growth factor beta receptor signaling pathway [GO:0007179]; triglyceride mobilization [GO:0006642]; UV-damage excision repair [GO:0070914]; vasodilation [GO:0042311]; white fat cell differentiation [GO:0050872]	bHLH transcription factor binding [GO:0043425]; caspase binding [GO:0089720]; deacetylase activity [GO:0019213]; DNA-binding transcription factor binding [GO:0140297]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone deacetylase activity [GO:0004407]; histone deacetylase activity, NAD-dependent [GO:0017136]; histone decrotonylase activity, NAD-dependent [GO:0160012]; histone H3K deacetylase activity [GO:0141050]; histone H3K14 deacetylase activity, NAD-dependent [GO:0032041]; histone H3K9 deacetylase activity, NAD-dependent [GO:0046969]; histone H4K12 deacetylase activity, hydrolytic mechanism [GO:0140937]; histone H4K16 deacetylase activity, NAD-dependent [GO:0046970]; HLH domain binding [GO:0043398]; identical protein binding [GO:0042802]; keratin filament binding [GO:1990254]; mitogen-activated protein kinase binding [GO:0051019]; NAD+ binding [GO:0070403]; NAD-dependent protein decrotonylase activity [GO:0160011]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; NAD-dependent protein lysine delactylase activity [GO:0141208]; NAD-dependent protein-lysine depropionylase activity [GO:0106231]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; protein kinase B binding [GO:0043422]; protein lysine deacetylase activity [GO:0033558]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]	axon [GO:0030424]; chromatin [GO:0000785]; chromatin silencing complex [GO:0005677]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; euchromatin [GO:0000791]; growth cone [GO:0030426]; heterochromatin [GO:0000792]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; rDNA heterochromatin [GO:0033553]	GO:0000012; GO:0000122; GO:0000183; GO:0000720; GO:0000731; GO:0000781; GO:0000785; GO:0000791; GO:0000792; GO:0000978; GO:0001525; GO:0001542; GO:0001678; GO:0001934; GO:0001938; GO:0002039; GO:0002821; GO:0003713; GO:0003714; GO:0004407; GO:0004857; GO:0005634; GO:0005635; GO:0005637; GO:0005654; GO:0005677; GO:0005730; GO:0005737; GO:0005739; GO:0005829; GO:0006325; GO:0006476; GO:0006642; GO:0006974; GO:0006979; GO:0007005; GO:0007179; GO:0007283; GO:0007346; GO:0007623; GO:0008047; GO:0008284; GO:0008630; GO:0009267; GO:0010046; GO:0010460; GO:0010628; GO:0010629; GO:0010659; GO:0010667; GO:0010824; GO:0010868; GO:0010875; GO:0010883; GO:0010898; GO:0010906; GO:0010918; GO:0010976; GO:0014858; GO:0016239; GO:0016567; GO:0016605; GO:0016922; GO:0017136; GO:0018394; GO:0019213; GO:0019899; GO:0019904; GO:0030225; GO:0030424; GO:0030426; GO:0030512; GO:0030968; GO:0031393; GO:0031507; GO:0031509; GO:0031648; GO:0031667; GO:0032007; GO:0032041; GO:0032071; GO:0032436; GO:0032720; GO:0032868; GO:0032922; GO:0032991; GO:0033210; GO:0033553; GO:0033558; GO:0034391; GO:0034979; GO:0035098; GO:0035331; GO:0035356; GO:0035358; GO:0035774; GO:0042127; GO:0042149; GO:0042220; GO:0042311; GO:0042326; GO:0042393; GO:0042542; GO:0042595; GO:0042632; GO:0042771; GO:0042802; GO:0042981; GO:0043065; GO:0043066; GO:0043124; GO:0043161; GO:0043398; GO:0043422; GO:0043425; GO:0043518; GO:0043524; GO:0043536; GO:0044321; GO:0045348; GO:0045471; GO:0045599; GO:0045722; GO:0045739; GO:0045766; GO:0045786; GO:0045892; GO:0045944; GO:0046015; GO:0046628; GO:0046969; GO:0046970; GO:0050872; GO:0051019; GO:0051152; GO:0051402; GO:0051658; GO:0051897; GO:0051898; GO:0055089; GO:0060125; GO:0060766; GO:0060907; GO:0061051; GO:0070301; GO:0070403; GO:0070857; GO:0070914; GO:0071236; GO:0071303; GO:0071356; GO:0071456; GO:0071479; GO:0089720; GO:0090312; GO:0090335; GO:0090400; GO:0097009; GO:0097193; GO:0106230; GO:0106231; GO:0140297; GO:0140416; GO:0140861; GO:0140937; GO:0141050; GO:0141208; GO:0160011; GO:0160012; GO:1900181; GO:1901797; GO:1901984; GO:1902166; GO:1902176; GO:1902237; GO:1902424; GO:1902617; GO:1903427; GO:1904178; GO:1904179; GO:1904262; GO:1904373; GO:1904638; GO:1904639; GO:1904644; GO:1904646; GO:1904648; GO:1904710; GO:1990254; GO:1990830; GO:1990841; GO:2000111; GO:2000270; GO:2000481; GO:2000614; GO:2000655; GO:2000757; GO:2000773; GO:2000774; GO:2000781; GO:2001171
GN012125	GN012125.1	P36189	68.5	92	145	352	5.84e-40	140	FAS_ANSAN	Fatty acid synthase (EC 2.3.1.85)	Anser anser anser (Western greylag goose)	fatty acid biosynthetic process [GO:0006633]	3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; fatty acid synthase activity [GO:0004312]	cytoplasm [GO:0005737]	GO:0004312; GO:0004315; GO:0005737; GO:0006633
GN012126	GN012126.1	Q9NQ29	68.3	189	337	371	3.45e-83	259	LUC7L_HUMAN	Putative RNA-binding protein Luc7-like 1 (Putative SR protein LUC7B1) (SR+89)	Homo sapiens (Human)	mRNA splice site recognition [GO:0006376]	identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; RS domain binding [GO:0050733]	U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]	GO:0003729; GO:0005685; GO:0006376; GO:0042802; GO:0050733; GO:0071004
GN012128	GN012128.1	Q2KHW8	40.4	156	177	166	2.26e-33	119	GEMI6_BOVIN	Gem-associated protein 6 (Gemin-6)	Bos taurus (Bovine)	spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of Cajal bodies [GO:0097504]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]	GO:0000245; GO:0000387; GO:0003723; GO:0005737; GO:0005829; GO:0032797; GO:0034719; GO:0097504
GN012129	GN012129.1	Q7Z3J2	58.6	309	318	963	2.65e-121	374	VP35L_HUMAN	VPS35 endosomal protein-sorting factor-like (Esophageal cancer-associated protein)	Homo sapiens (Human)	endocytic recycling [GO:0032456]; Golgi to plasma membrane transport [GO:0006893]		endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GO:0005768; GO:0005789; GO:0005886; GO:0006893; GO:0010008; GO:0032456; GO:0032991; GO:0101003
GN012130	GN012130.1	Q9ER34	75.1	762	776	780	0.0	1189	ACON_RAT	Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)	Rattus norvegicus (Rat)	citrate metabolic process [GO:0006101]; isocitrate metabolic process [GO:0006102]; liver development [GO:0001889]; response to isolation stress [GO:0035900]; tricarboxylic acid cycle [GO:0006099]	3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; iron ion binding [GO:0005506]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0001889; GO:0003994; GO:0005506; GO:0005739; GO:0005759; GO:0005829; GO:0006099; GO:0006101; GO:0006102; GO:0035900; GO:0051538; GO:0051539
GN012132	GN012132.1	P92208	81.5	367	416	372	2.07e-223	619	JNK_DROME	Stress-activated protein kinase JNK (dJNK) (EC 2.7.11.24) (Protein basket)	Drosophila melanogaster (Fruit fly)	antibacterial humoral response [GO:0019731]; axon extension [GO:0048675]; axon guidance [GO:0007411]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to cadmium ion [GO:0071276]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; chorion micropyle formation [GO:0046844]; collateral sprouting of injured axon [GO:0048674]; defense response to Gram-negative bacterium [GO:0050829]; determination of digestive tract left/right asymmetry [GO:0071907]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; dorsal closure, spreading of leading edge cells [GO:0007395]; embryonic anterior midgut (ectodermal) morphogenesis [GO:0048615]; engulfment of apoptotic cell [GO:0043652]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; follicle cell of egg chamber development [GO:0030707]; imaginal disc fusion, thorax closure [GO:0046529]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; JNK cascade [GO:0007254]; long-term memory [GO:0007616]; melanization defense response [GO:0035006]; mushroom body development [GO:0016319]; neuron development [GO:0048666]; neuron projection morphogenesis [GO:0048812]; peptidoglycan recognition protein signaling pathway [GO:0061057]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of border follicle cell migration [GO:1903688]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron remodeling [GO:1904801]; positive regulation of programmed cell death [GO:0043068]; regulation of cellular response to phosphate starvation [GO:0140255]; regulation of wound healing, spreading of epidermal cells [GO:1903689]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; wound healing [GO:0042060]; wound healing, spreading of epidermal cells [GO:0035313]	ATP binding [GO:0005524]; JUN kinase activity [GO:0004705]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004672; GO:0004674; GO:0004705; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006979; GO:0007254; GO:0007391; GO:0007395; GO:0007411; GO:0007616; GO:0008284; GO:0009408; GO:0010508; GO:0010628; GO:0016319; GO:0019731; GO:0030424; GO:0030425; GO:0030707; GO:0033209; GO:0034599; GO:0034614; GO:0035006; GO:0035313; GO:0042060; GO:0043065; GO:0043068; GO:0043652; GO:0046529; GO:0046843; GO:0046844; GO:0048010; GO:0048615; GO:0048666; GO:0048674; GO:0048675; GO:0048803; GO:0048812; GO:0050829; GO:0061057; GO:0071243; GO:0071276; GO:0071907; GO:0071963; GO:0106310; GO:0140255; GO:1903688; GO:1903689; GO:1904801
GN012133	GN012133.1	Q8N264	45.4	339	584	748	2.65e-93	305	RHG24_HUMAN	Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP)	Homo sapiens (Human)	negative regulation of Rac protein signal transduction [GO:0035021]; negative regulation of ruffle assembly [GO:1900028]; signal transduction [GO:0007165]; wound healing, spreading of epidermal cells [GO:0035313]	GTPase activator activity [GO:0005096]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]	GO:0005096; GO:0005856; GO:0005912; GO:0005925; GO:0007165; GO:0035021; GO:0035313; GO:1900028
GN012134	GN012134.1	E1JIT7	59.6	421	798	1601	4.22e-152	487	PSD_DROME	PH and SEC7 domain-containing protein (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for Arf 6)	Drosophila melanogaster (Fruit fly)	axoneme assembly [GO:0035082]; compound eye morphogenesis [GO:0001745]; negative regulation of microtubule polymerization [GO:0031115]; positive regulation of ARF protein signal transduction [GO:0032014]; response to alcohol [GO:0097305]	guanyl-nucleotide exchange factor activity [GO:0005085]; microtubule binding [GO:0008017]; phospholipid binding [GO:0005543]	axon [GO:0030424]; cell body [GO:0044297]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	GO:0000139; GO:0001745; GO:0005085; GO:0005543; GO:0005737; GO:0005886; GO:0005938; GO:0008017; GO:0030424; GO:0031115; GO:0032014; GO:0032587; GO:0035082; GO:0044297; GO:0097305
GN012136	GN012136.1	Q8R4C2	46.4	614	654	606	2.47e-141	428	RUFY2_MOUSE	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE)	Mus musculus (Mouse)		metal ion binding [GO:0046872]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0017124; GO:0046872
GN012137	GN012137.1	Q4V9Y5	36.7	150	160	500	7.12e-24	99.8	CRLD2_XENTR	Cysteine-rich secretory protein LCCL domain-containing 2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			extracellular region [GO:0005576]	GO:0005576
GN012140	GN012140.1	A0A1W2PR82	34.8	187	286	267	8.80e-23	97.8	PERC1_HUMAN	Protein PERCC1 (Proline and glutamage-rich protein with a coiled coil domain)	Homo sapiens (Human)	digestive tract morphogenesis [GO:0048546]; enteroendocrine cell differentiation [GO:0035883]			GO:0035883; GO:0048546
GN012141	GN012141.1	Q68FJ0	41.0	273	275	653	5.13e-66	220	NUP85_XENLA	Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (Nucleoporin Nup85)	Xenopus laevis (African clawed frog)	mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; positive regulation of DNA-templated transcription [GO:0045893]; protein import into nucleus [GO:0006606]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore outer ring [GO:0031080]	GO:0005829; GO:0006406; GO:0006606; GO:0017056; GO:0031080; GO:0031965; GO:0045893; GO:0072006
GN012142	GN012142.1	O54983	53.2	299	337	313	2.98e-97	293	CRYM_MOUSE	Ketimine reductase mu-crystallin (EC 1.5.1.25) (1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase) (P2C/Pyr2C reductase) (EC 1.5.1.1) (NADP-regulated thyroid-hormone-binding protein)	Mus musculus (Mouse)	amino acid catabolic process [GO:0009063]; L-lysine catabolic process [GO:0019477]; mitochondrial transport [GO:0006839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; sensory perception of sound [GO:0007605]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327]	delta1-piperideine-2-carboxylate reductase activity [GO:0047125]; hormone binding [GO:0042562]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; pyrroline-2-carboxylate reductase activity [GO:0050241]; thiomorpholine-carboxylate dehydrogenase activity [GO:0047127]; thyroid hormone binding [GO:0070324]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]	GO:0000122; GO:0003714; GO:0005634; GO:0005737; GO:0005739; GO:0005782; GO:0005829; GO:0006839; GO:0007605; GO:0009063; GO:0019477; GO:0042403; GO:0042562; GO:0042803; GO:0047125; GO:0047127; GO:0050241; GO:0050661; GO:0070324; GO:0070327
GN012144	GN012144.1	P02552	97.6	451	451	451	0.0	903	TBA1A_CHICK	Tubulin alpha-1A chain (EC 3.6.5.-) [Cleaved into: Detyrosinated tubulin alpha-1A chain]	Gallus gallus (Chicken)	microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; neuron differentiation [GO:0030182]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]	microtubule [GO:0005874]	GO:0000278; GO:0003924; GO:0005200; GO:0005525; GO:0005874; GO:0007017; GO:0030182
GN012145	GN012145.1	P02552	97.7	436	436	451	0.0	874	TBA1A_CHICK	Tubulin alpha-1A chain (EC 3.6.5.-) [Cleaved into: Detyrosinated tubulin alpha-1A chain]	Gallus gallus (Chicken)	microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; neuron differentiation [GO:0030182]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]	microtubule [GO:0005874]	GO:0000278; GO:0003924; GO:0005200; GO:0005525; GO:0005874; GO:0007017; GO:0030182
GN012146	GN012146.1	Q7T0L6	40.5	610	758	761	7.90e-145	446	CCNF_XENLA	Cyclin-F	Xenopus laevis (African clawed frog)	negative regulation of centrosome duplication [GO:0010826]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	centriole [GO:0005814]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005]	GO:0000307; GO:0005634; GO:0005814; GO:0005815; GO:0010826; GO:0016538; GO:0016567; GO:0019005; GO:0031146; GO:0048471
GN012147	GN012147.1	Q4G0X9	38.6	869	1069	1142	1.62e-168	529	CCD40_HUMAN	Coiled-coil domain-containing protein 40	Homo sapiens (Human)	axonemal dynein complex assembly [GO:0070286]; axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; cilium organization [GO:0044782]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; protein localization to cilium [GO:0061512]; regulation of cilium beat frequency [GO:0003356]		axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; motile cilium [GO:0031514]	GO:0001947; GO:0003341; GO:0003351; GO:0003356; GO:0005576; GO:0005737; GO:0005929; GO:0005930; GO:0030317; GO:0030324; GO:0031514; GO:0035082; GO:0035469; GO:0036159; GO:0044458; GO:0044782; GO:0060287; GO:0061512; GO:0070286; GO:0071907; GO:0071910
GN012148	GN012148.1	Q8TBP0	60.8	451	949	767	1.60e-198	591	TBC16_HUMAN	TBC1 domain family member 16	Homo sapiens (Human)	regulation of receptor recycling [GO:0001919]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; early endosome [GO:0005769]	GO:0001919; GO:0005096; GO:0005769; GO:0005829
GN012149	GN012149.1	Q60HE9	47.7	1011	1029	1012	1.54e-298	859	MA2B1_MACFA	Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	mannose metabolic process [GO:0006013]	alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]	extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]	GO:0004559; GO:0005576; GO:0006013; GO:0030246; GO:0043202
GN012150	GN012150.1	Q8K2Y9	29.7	340	401	453	9.78e-34	134	CCM2_MOUSE	Cerebral cavernous malformations protein 2 homolog (Malcavernin) (Osmosensing scaffold for MEKK3)	Mus musculus (Mouse)	blood vessel development [GO:0001568]; blood vessel endothelial cell differentiation [GO:0060837]; cell-cell junction organization [GO:0045216]; endothelial cell development [GO:0001885]; endothelial tube morphogenesis [GO:0061154]; endothelium development [GO:0003158]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; inner ear development [GO:0048839]; multicellular organism growth [GO:0035264]; pericardium development [GO:0060039]; regulation of angiogenesis [GO:0045765]; vasculature development [GO:0001944]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]		cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	GO:0001568; GO:0001570; GO:0001701; GO:0001885; GO:0001944; GO:0003158; GO:0005737; GO:0005739; GO:0007507; GO:0032991; GO:0035264; GO:0045216; GO:0045765; GO:0048839; GO:0048845; GO:0060039; GO:0060837; GO:0061154
GN012151	GN012151.1	Q6PJ21	35.1	231	232	355	9.03e-32	122	SPSB3_HUMAN	SPRY domain-containing SOCS box protein 3 (SSB-3)	Homo sapiens (Human)	negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005634; GO:0005829; GO:0010719; GO:0019005; GO:0031466; GO:0043161; GO:0070936; GO:0160049; GO:1990756
GN012152	GN012152.1	Q8NE09	32.4	1329	1536	1264	3.93e-181	578	RGS22_HUMAN	Regulator of G protein signaling 22 (RGS22)	Homo sapiens (Human)	regulation of signal transduction [GO:0009966]	G-protein alpha-subunit binding [GO:0001965]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleus [GO:0005634]	GO:0001650; GO:0001965; GO:0005634; GO:0005737; GO:0005829; GO:0009966
GN012153	GN012153.1	P97767	78.1	274	648	591	9.09e-151	451	EYA1_MOUSE	Protein phosphatase EYA1 (EC 3.1.3.16) (EC 3.1.3.48) (Eyes absent homolog 1)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; aorta morphogenesis [GO:0035909]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cochlea morphogenesis [GO:0090103]; double-strand break repair [GO:0006302]; embryonic skeletal system morphogenesis [GO:0048704]; inner ear morphogenesis [GO:0042472]; mesodermal cell fate specification [GO:0007501]; metanephros development [GO:0001656]; middle ear morphogenesis [GO:0042474]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; neuron fate specification [GO:0048665]; otic vesicle development [GO:0071599]; otic vesicle morphogenesis [GO:0071600]; outer ear morphogenesis [GO:0042473]; outflow tract morphogenesis [GO:0003151]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein dephosphorylation [GO:0006470]; protein sumoylation [GO:0016925]; regulation of neuron differentiation [GO:0045664]; response to ionizing radiation [GO:0010212]; semicircular canal morphogenesis [GO:0048752]; striated muscle tissue development [GO:0014706]; ureteric bud development [GO:0001657]	histone H2AXY142 phosphatase activity [GO:0140793]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]	GO:0001656; GO:0001657; GO:0001658; GO:0003151; GO:0003723; GO:0004722; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006470; GO:0007389; GO:0007501; GO:0009887; GO:0010212; GO:0014706; GO:0016604; GO:0016925; GO:0030154; GO:0032991; GO:0032993; GO:0035909; GO:0042472; GO:0042473; GO:0042474; GO:0045165; GO:0045664; GO:0045739; GO:0045893; GO:0045944; GO:0048665; GO:0048704; GO:0048752; GO:0050679; GO:0060037; GO:0071599; GO:0071600; GO:0072513; GO:0090103; GO:0140793; GO:2001240
GN012154	GN012154.1	B2RVL6	75.5	151	235	241	2.11e-86	259	ZCH24_MOUSE	Zinc finger CCHC domain-containing protein 24	Mus musculus (Mouse)		nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]		GO:0003676; GO:0008270
GN012155	GN012155.1	A0A0R4IVV0	29.5	867	942	884	1.37e-108	359	MTP_DANRE	Microsomal triglyceride transfer protein large subunit	Danio rerio (Zebrafish) (Brachydanio rerio)	cholesterol homeostasis [GO:0042632]; digestion [GO:0007586]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; plasma lipoprotein particle assembly [GO:0034377]; protein secretion [GO:0009306]; sprouting angiogenesis [GO:0002040]	lipid binding [GO:0008289]; lipid carrier activity [GO:0005319]; lipid transfer activity [GO:0120013]; phosphatidylethanolamine transfer activity [GO:1904121]	basolateral plasma membrane [GO:0016323]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]	GO:0001579; GO:0002040; GO:0005319; GO:0005783; GO:0005794; GO:0006629; GO:0006869; GO:0007586; GO:0008289; GO:0009306; GO:0015909; GO:0016323; GO:0034377; GO:0042157; GO:0042158; GO:0042632; GO:0042953; GO:0120013; GO:1904121
GN012156	GN012156.1	Q8TBZ6	51.7	176	297	339	1.38e-56	188	TM10A_HUMAN	tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A)	Homo sapiens (Human)	tRNA methylation [GO:0030488]; tRNA N1-guanine methylation [GO:0002939]	RNA binding [GO:0003723]; tRNA (guanosine(9)-N1)-methyltransferase activity [GO:0052905]; tRNA binding [GO:0000049]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000049; GO:0002939; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0030488; GO:0052905; GO:0070062
GN012158	GN012158.1	Q503W7	53.8	342	425	362	9.82e-123	363	ATD1B_DANRE	Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	extraction of mislocalized protein from mitochondrial outer membrane [GO:0140570]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; membrane protein dislocase activity [GO:0140567]	mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778]; postsynaptic membrane [GO:0045211]	GO:0005524; GO:0005741; GO:0005778; GO:0016887; GO:0045211; GO:0140567; GO:0140570
GN012159	GN012159.1	A0JP70	46.3	1910	1939	1848	0.0	1686	WDR90_XENTR	WD repeat-containing protein 90	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	centriole elongation [GO:0061511]; cilium assembly [GO:0060271]	microtubule binding [GO:0008017]	centriolar satellite [GO:0034451]; centriole [GO:0005814]	GO:0005814; GO:0008017; GO:0034451; GO:0060271; GO:0061511
GN012162	GN012162.1	Q94B65	33.0	297	383	323	2.47e-36	137	UTR7_ARATH	UDP-galactose/UDP-glucose transporter 7 (AtUTr7)	Arabidopsis thaliana (Mouse-ear cress)	lateral root development [GO:0048527]; root hair cell development [GO:0080147]; UDP-galactose transmembrane transport [GO:0072334]; UDP-glucose transmembrane transport [GO:0015786]	UDP-galactose transmembrane transporter activity [GO:0005459]; UDP-glucose transmembrane transporter activity [GO:0005460]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	GO:0000139; GO:0005459; GO:0005460; GO:0005794; GO:0005886; GO:0015786; GO:0048527; GO:0072334; GO:0080147
GN012163	GN012163.1	D3Z3C6	38.0	716	622	739	4.01e-101	327	ZFAN4_MOUSE	AN1-type zinc finger protein 4 (AN1-type zinc finger and ubiquitin domain-containing protein-like 1)	Mus musculus (Mouse)		zinc ion binding [GO:0008270]		GO:0008270
GN012164	GN012164.1	Q9LZG0	56.8	347	363	345	5.12e-140	404	ADK2_ARATH	Adenosine kinase 2 (AK 2) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase 2) (N6,N6-dimethyladenosine kinase 2) (EC 2.7.1.-) (N6-isopentenyladenosine kinase 2) (EC 2.7.1.-) (N6-methyladenosine kinase 2) (EC 2.7.1.-)	Arabidopsis thaliana (Mouse-ear cress)	adenosine salvage [GO:0006169]; AMP salvage [GO:0044209]; purine nucleobase metabolic process [GO:0006144]; toxic metabolite repair [GO:0110052]	adenosine kinase activity [GO:0004001]; copper ion binding [GO:0005507]; kinase binding [GO:0019900]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0004001; GO:0005507; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006144; GO:0006169; GO:0019900; GO:0044209; GO:0110052
GN012166	GN012166.1	A7RUD5	73.7	304	312	318	1.47e-176	493	NUBP1_NEMVE	Cytosolic Fe-S cluster assembly factor NUBP1 homolog	Nematostella vectensis (Starlet sea anemone)	iron-sulfur cluster assembly [GO:0016226]	4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]; iron-sulfur cluster binding [GO:0051536]	cytosol [GO:0005829]	GO:0005524; GO:0005829; GO:0016226; GO:0051536; GO:0051539; GO:0140663
GN012167	GN012167.1	Q15822	38.0	326	562	529	2.01e-74	249	ACHA2_HUMAN	Neuronal acetylcholine receptor subunit alpha-2 (Nicotinic acetylcholine receptor subunit alpha-2)	Homo sapiens (Human)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; cellular response to nicotine [GO:0071316]; membrane depolarization [GO:0051899]; modulation of inhibitory postsynaptic potential [GO:0098828]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; heterocyclic compound binding [GO:1901363]; neurotransmitter receptor activity [GO:0030594]; quaternary ammonium group binding [GO:0050997]	acetylcholine-gated channel complex [GO:0005892]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuron projection cytoplasm [GO:0120111]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005886; GO:0005892; GO:0006811; GO:0006816; GO:0007165; GO:0007271; GO:0007274; GO:0015464; GO:0016020; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0043005; GO:0045202; GO:0045211; GO:0050997; GO:0051899; GO:0071316; GO:0095500; GO:0097060; GO:0098793; GO:0098828; GO:0099171; GO:0120111; GO:1901363
GN012168	GN012168.1	Q9PTS8	35.5	470	507	484	9.59e-86	275	ACHA9_CHICK	Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0097060; GO:1902495
GN012170	GN012170.1	Q8BX80	41.0	539	616	734	1.63e-126	392	ENASE_MOUSE	Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96)	Mus musculus (Mouse)	protein deglycosylation [GO:0006517]	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity [GO:0033925]	cytosol [GO:0005829]	GO:0005829; GO:0006517; GO:0033925
GN012172	GN012172.1	Q8WYB5	38.2	1184	2041	2073	4.21e-201	664	KAT6B_HUMAN	Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor)	Homo sapiens (Human)	negative regulation of DNA-templated transcription [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of developmental process [GO:0050793]; regulation of DNA-templated transcription [GO:0006355]; regulation of hemopoiesis [GO:1903706]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone acetyltransferase activity [GO:0004402]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K14 acetyltransferase activity [GO:0036408]; protein-containing complex binding [GO:0044877]; protein-lysine-acetyltransferase activity [GO:0061733]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]	MOZ/MORF histone acetyltransferase complex [GO:0070776]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	GO:0000786; GO:0003677; GO:0003682; GO:0003712; GO:0003713; GO:0004402; GO:0005634; GO:0005654; GO:0006334; GO:0006355; GO:0006357; GO:0010484; GO:0036408; GO:0044877; GO:0045892; GO:0045893; GO:0045944; GO:0050793; GO:0061733; GO:0070776; GO:1903706
GN012173	GN012173.1	Q18248	45.2	210	385	260	3.56e-40	146	DMD4_CAEEL	Doublesex- and mab-3-related transcription factor dmd-4	Caenorhabditis elegans	regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]; synapse pruning [GO:0098883]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; ubiquitin binding [GO:0043130]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0007548; GO:0043130; GO:0098883
GN012174	GN012174.1	Q63042	57.7	149	168	198	1.01e-59	187	ALR_RAT	FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration)	Rattus norvegicus (Rat)	cellular response to actinomycin D [GO:0072717]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to toxic substance [GO:0097237]; cellular response to tumor necrosis factor [GO:0071356]; liver development [GO:0001889]; liver regeneration [GO:0097421]; negative regulation of apoptotic process [GO:0043066]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; positive regulation of DNA biosynthetic process [GO:2000573]; protein import into the intermembrane space via the disulfide relay system [GO:0160203]; response to lipopolysaccharide [GO:0032496]	flavin adenine dinucleotide binding [GO:0050660]; flavin-dependent sulfhydryl oxidase activity [GO:0016971]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972]	cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]	GO:0001889; GO:0005576; GO:0005739; GO:0005758; GO:0005829; GO:0015035; GO:0016971; GO:0016972; GO:0032496; GO:0043066; GO:0045953; GO:0050660; GO:0071222; GO:0071356; GO:0072717; GO:0097237; GO:0097421; GO:0160203; GO:2000573
GN012177	GN012177.1	Q6IE24	53.7	285	1728	1588	3.95e-86	316	UBP54_RAT	Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54)	Rattus norvegicus (Rat)	protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578]		GO:0004843; GO:0016579; GO:0061578
GN012179	GN012179.1	O70247	42.7	581	645	634	4.46e-147	443	SC5A6_RAT	Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6)	Rattus norvegicus (Rat)	biotin import across plasma membrane [GO:1905135]; biotin metabolic process [GO:0006768]; biotin transport [GO:0015878]; iodide transmembrane transport [GO:1904200]; pantothenate transmembrane transport [GO:0015887]; sodium ion transport [GO:0006814]; transport across blood-brain barrier [GO:0150104]	biotin transmembrane transporter activity [GO:0015225]; iodide transmembrane transporter activity [GO:0015111]; pantothenate transmembrane transporter activity [GO:0015233]; pantothenate:sodium symporter activity [GO:0015498]; sodium-dependent multivitamin transmembrane transporter activity [GO:0008523]; vitamin transmembrane transporter activity [GO:0090482]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; plasma membrane [GO:0005886]	GO:0005886; GO:0006768; GO:0006814; GO:0008523; GO:0009925; GO:0015111; GO:0015225; GO:0015233; GO:0015498; GO:0015878; GO:0015887; GO:0016323; GO:0016324; GO:0031526; GO:0090482; GO:0150104; GO:1904200; GO:1905135
GN012180	GN012180.1	Q8VHW4	44.5	110	235	275	3.27e-21	92.4	CCG5_MOUSE	Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5)	Mus musculus (Mouse)	positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970]; regulation of AMPA receptor activity [GO:2000311]; transmission of nerve impulse [GO:0019226]	channel regulator activity [GO:0016247]; voltage-gated calcium channel activity [GO:0005245]	AMPA glutamate receptor complex [GO:0032281]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]	GO:0005245; GO:0014069; GO:0016247; GO:0019226; GO:0032281; GO:0045211; GO:0051968; GO:0098839; GO:0098970; GO:0098978; GO:2000311
GN012181	GN012181.1	Q99J99	48.4	283	294	297	7.58e-93	280	THTM_MOUSE	3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2)	Mus musculus (Mouse)	hydrogen sulfide biosynthetic process [GO:0070814]; kidney development [GO:0001822]; liver development [GO:0001889]; spinal cord development [GO:0021510]; transsulfuration [GO:0019346]; tRNA wobble position uridine thiolation [GO:0002143]	3-mercaptopyruvate sulfurtransferase activity [GO:0016784]; identical protein binding [GO:0042802]; thiosulfate-cyanide sulfurtransferase activity [GO:0004792]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; synapse [GO:0045202]	GO:0001822; GO:0001889; GO:0002143; GO:0004792; GO:0005737; GO:0005739; GO:0005743; GO:0016784; GO:0019346; GO:0021510; GO:0042802; GO:0043005; GO:0045202; GO:0070814
GN012183	GN012183.1	Q9NR12	38.8	116	1208	457	5.93e-12	73.2	PDLI7_HUMAN	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]; receptor-mediated endocytosis [GO:0006898]	actin binding [GO:0003779]; muscle alpha-actinin binding [GO:0051371]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018]	GO:0001725; GO:0001726; GO:0003779; GO:0005829; GO:0005912; GO:0005925; GO:0006898; GO:0007507; GO:0015629; GO:0030018; GO:0030036; GO:0031941; GO:0051371; GO:0061061
GN012189	GN012189.1	Q9V3L1	56.2	825	835	1048	0.0	939	NDST_DROME	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase) (Protein sulfateless) [Includes: Heparan sulfate N-deacetylase (EC 3.-.-.-); Heparan sulfate N-sulfotransferase (EC 2.8.2.-)]	Drosophila melanogaster (Fruit fly)	epithelial cell migration, open tracheal system [GO:0007427]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin proteoglycan biosynthetic process [GO:0030210]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing vein specification [GO:0007474]; mesoderm migration involved in gastrulation [GO:0007509]; regulation of imaginal disc growth [GO:0045570]; segment polarity determination [GO:0007367]; spermatogenesis [GO:0007283]; sulfur compound metabolic process [GO:0006790]; Wnt signaling pathway [GO:0016055]	deacetylase activity [GO:0019213]; heparan sulfate N-deacetylase activity [GO:0102140]; heparan sulfate N-sulfotransferase activity [GO:0015016]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]	GO:0000137; GO:0000139; GO:0005783; GO:0005794; GO:0006024; GO:0006790; GO:0007283; GO:0007367; GO:0007427; GO:0007474; GO:0007509; GO:0008543; GO:0008587; GO:0015012; GO:0015016; GO:0016055; GO:0019213; GO:0030210; GO:0045570; GO:0102140
GN012191	GN012191.1	A8DZE7	50.7	381	409	387	6.17e-131	384	D42E1_DANRE	Short-chain dehydrogenase/reductase family 42E member 1 (EC 1.1.1.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	steroid biosynthetic process [GO:0006694]	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	membrane [GO:0016020]	GO:0006694; GO:0016020; GO:0016616
GN012195	GN012195.1	P12004	75.2	121	122	261	4.01e-60	188	PCNA_HUMAN	DNA sliding clamp PCNA (Cyclin) (Proliferating cell nuclear antigen) (PCNA)	Homo sapiens (Human)	cellular response to hydrogen peroxide [GO:0070301]; cellular response to UV [GO:0034644]; chromatin organization [GO:0006325]; DNA repair-dependent chromatin remodeling [GO:0140861]; epithelial cell differentiation [GO:0030855]; estrous cycle [GO:0044849]; heart development [GO:0007507]; leading strand elongation [GO:0006272]; liver regeneration [GO:0097421]; mismatch repair [GO:0006298]; mitotic DNA replication [GO:1902969]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; replication fork processing [GO:0031297]; response to cadmium ion [GO:0046686]; response to dexamethasone [GO:0071548]; response to estradiol [GO:0032355]; response to L-glutamate [GO:1902065]; translesion synthesis [GO:0019985]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; dinucleotide insertion or deletion binding [GO:0032139]; DNA polymerase binding [GO:0070182]; DNA polymerase processivity factor activity [GO:0030337]; enzyme binding [GO:0019899]; histone acetyltransferase binding [GO:0035035]; identical protein binding [GO:0042802]; MutLalpha complex binding [GO:0032405]; nuclear estrogen receptor binding [GO:0030331]; protein-containing complex binding [GO:0044877]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]; receptor tyrosine kinase binding [GO:0030971]	centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; extracellular exosome [GO:0070062]; nuclear lamina [GO:0005652]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCNA complex [GO:0043626]; PCNA-p21 complex [GO:0070557]; replication fork [GO:0005657]; replisome [GO:0030894]	GO:0000307; GO:0000701; GO:0000781; GO:0000785; GO:0003682; GO:0003684; GO:0005634; GO:0005652; GO:0005654; GO:0005657; GO:0005813; GO:0006272; GO:0006298; GO:0006325; GO:0007507; GO:0019899; GO:0019985; GO:0030331; GO:0030337; GO:0030855; GO:0030894; GO:0030971; GO:0031297; GO:0032139; GO:0032355; GO:0032405; GO:0034644; GO:0035035; GO:0042802; GO:0043596; GO:0043626; GO:0044849; GO:0044877; GO:0045739; GO:0045740; GO:0046686; GO:0070062; GO:0070182; GO:0070301; GO:0070557; GO:0071548; GO:0097421; GO:0140861; GO:1902065; GO:1902969; GO:1902990
GN012196	GN012196.1	P17070	71.3	108	115	263	1.74e-49	160	PCNA_ORYSJ	DNA sliding clamp PCNA (Cyclin) (Proliferating cell nuclear antigen) (OsPCNA) (PCNA)	Oryza sativa subsp. japonica (Rice)	DNA repair-dependent chromatin remodeling [GO:0140861]; leading strand elongation [GO:0006272]; mismatch repair [GO:0006298]; mitotic DNA replication [GO:1902969]; protein homotrimerization [GO:0070207]; regulation of DNA replication [GO:0006275]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA polymerase processivity factor activity [GO:0030337]	nucleus [GO:0005634]; PCNA complex [GO:0043626]	GO:0003682; GO:0003684; GO:0005634; GO:0006272; GO:0006275; GO:0006298; GO:0030337; GO:0043626; GO:0070207; GO:0140861; GO:1902969
GN012197	GN012197.1	A2VEI2	58.5	386	522	525	6.71e-158	462	MICU1_DROME	Calcium uptake protein 1 homolog, mitochondrial (Mitochondrial calcium uptake 1)	Drosophila melanogaster (Fruit fly)	anesthesia-resistant memory [GO:0007615]; calcium import into the mitochondrion [GO:0036444]; medium-term memory [GO:0072375]; mitochondrial calcium ion homeostasis [GO:0051560]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]	calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; uniplex complex [GO:1990246]	GO:0005246; GO:0005509; GO:0005743; GO:0005758; GO:0007615; GO:0036444; GO:0051560; GO:0051561; GO:0072375; GO:1990246
GN012198	GN012198.1	A6QLG5	89.5	181	188	194	3.47e-109	313	RS9_BOVIN	Small ribosomal subunit protein uS4 (40S ribosomal protein S9)	Bos taurus (Bovine)	ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic small ribosomal subunit [GO:0022627]; ribonucleoprotein complex [GO:1990904]; small-subunit processome [GO:0032040]; synapse [GO:0045202]	GO:0003735; GO:0005737; GO:0006412; GO:0019843; GO:0022627; GO:0032040; GO:0042274; GO:0045202; GO:1990904
GN012200	GN012200.1	Q9CQC9	73.7	179	182	198	5.87e-98	284	SAR1B_MOUSE	Small COPII coat GTPase SAR1B (EC 3.6.5.2)	Mus musculus (Mouse)	cellular response to leucine starvation [GO:1990253]; COPII vesicle coating [GO:0048208]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; lipid export from cell [GO:0140353]; lipid homeostasis [GO:0055088]; lipoprotein transport [GO:0042953]; membrane organization [GO:0061024]; negative regulation of TORC1 signaling [GO:1904262]; regulation of COPII vesicle coating [GO:0003400]; regulation of lipid transport [GO:0032368]; regulation of TORC1 signaling [GO:1903432]; vesicle organization [GO:0016050]	amino acid sensor activity [GO:0140785]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; lysosomal membrane [GO:0005765]	GO:0003400; GO:0003924; GO:0003925; GO:0005525; GO:0005765; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0016050; GO:0030127; GO:0032368; GO:0032580; GO:0042953; GO:0048208; GO:0055088; GO:0061024; GO:0070971; GO:0090110; GO:0140353; GO:0140785; GO:1903432; GO:1904262; GO:1990253
GN012201	GN012201.1	Q5RD58	44.2	513	527	552	1.62e-142	424	FERY3_PONAB	FERRY endosomal RAB5 effector complex subunit 3	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	regulation of mast cell degranulation [GO:0043304]		cytoplasm [GO:0005737]; early endosome [GO:0005769]; protein-containing complex [GO:0032991]	GO:0005737; GO:0005769; GO:0032991; GO:0043304
GN012202	GN012202.1	Q60674	24.2	660	891	576	6.68e-34	141	NR1D2_MOUSE	Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear receptor RVR) (Rev-erb-beta)	Mus musculus (Mouse)	cell differentiation [GO:0030154]; circadian behavior [GO:0048512]; energy homeostasis [GO:0097009]; hormone-mediated signaling pathway [GO:0009755]; intracellular receptor signaling pathway [GO:0030522]; lipid homeostasis [GO:0055088]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of inflammatory response [GO:0050728]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of inflammatory response [GO:0050727]; regulation of lipid metabolic process [GO:0019216]; regulation of skeletal muscle cell differentiation [GO:2001014]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000987; GO:0001227; GO:0003677; GO:0003700; GO:0004879; GO:0005634; GO:0005654; GO:0005737; GO:0006355; GO:0008270; GO:0009755; GO:0019216; GO:0030154; GO:0030522; GO:0042752; GO:0045892; GO:0045893; GO:0045944; GO:0048512; GO:0050727; GO:0050728; GO:0055088; GO:0097009; GO:1990837; GO:2001014
GN012205	GN012205.1	Q86YT6	85.7	84	87	1006	1.84e-42	149	MIB1_HUMAN	E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2)	Homo sapiens (Human)	endocytosis [GO:0006897]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	GO:0004842; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0006511; GO:0006897; GO:0007219; GO:0008270; GO:0014069; GO:0016567; GO:0031410; GO:0034451; GO:0061630; GO:0098978
GN012209	GN012209.1	Q80SY4	77.3	397	376	1006	1.39e-163	487	MIB1_MOUSE	E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1)	Mus musculus (Mouse)	blood vessel development [GO:0001568]; endocytosis [GO:0006897]; heart development [GO:0007507]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; negative regulation of neuron differentiation [GO:0045665]; neural tube formation [GO:0001841]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; protein ubiquitination [GO:0016567]; somitogenesis [GO:0001756]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; glutamatergic synapse [GO:0098978]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	GO:0001568; GO:0001701; GO:0001756; GO:0001841; GO:0001947; GO:0005737; GO:0005813; GO:0005886; GO:0006511; GO:0006897; GO:0007219; GO:0007507; GO:0008270; GO:0014069; GO:0015630; GO:0016567; GO:0031410; GO:0034451; GO:0045665; GO:0045807; GO:0061630; GO:0098978
GN012211	GN012211.1	Q9I9E1	47.2	127	586	472	2.51e-26	115	FOXH1_DANRE	Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (Schmalspur protein)	Danio rerio (Zebrafish) (Brachydanio rerio)	anatomical structure morphogenesis [GO:0009653]; axial mesoderm morphogenesis [GO:0048319]; axial mesodermal cell fate specification [GO:0048327]; blood vessel development [GO:0001568]; brain morphogenesis [GO:0048854]; cell differentiation [GO:0030154]; cell migration involved in gastrulation [GO:0042074]; cellular response to cytokine stimulus [GO:0071345]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube left/right pattern formation [GO:0060971]; embryonic heart tube morphogenesis [GO:0003143]; endoderm formation [GO:0001706]; endodermal cell fate specification [GO:0001714]; floor plate development [GO:0033504]; floor plate formation [GO:0021508]; heart looping [GO:0001947]; hypothalamus development [GO:0021854]; lens placode formation involved in camera-type eye formation [GO:0046619]; mesendoderm development [GO:0048382]; mesoderm formation [GO:0001707]; mesodermal cell fate specification [GO:0007501]; negative regulation of transcription by RNA polymerase II [GO:0000122]; notochord development [GO:0030903]; notochord formation [GO:0014028]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prechordal plate formation [GO:0021501]; regulation of BMP signaling pathway [GO:0030510]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; somite rostral/caudal axis specification [GO:0032525]; specification of animal organ position [GO:0010159]; Spemann organizer formation at the embryonic shield [GO:0060063]; transforming growth factor beta receptor signaling pathway [GO:0007179]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; SMAD binding [GO:0046332]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000785; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0001568; GO:0001706; GO:0001707; GO:0001714; GO:0001947; GO:0003143; GO:0005634; GO:0005667; GO:0006357; GO:0007179; GO:0007368; GO:0007501; GO:0009653; GO:0009953; GO:0010159; GO:0010468; GO:0014028; GO:0021501; GO:0021508; GO:0021854; GO:0030154; GO:0030510; GO:0030903; GO:0032525; GO:0033504; GO:0042074; GO:0043565; GO:0045944; GO:0046332; GO:0046619; GO:0048319; GO:0048327; GO:0048382; GO:0048854; GO:0060063; GO:0060971; GO:0071345
GN012215	GN012215.1	O35245	28.7	439	513	966	5.29e-41	161	PKD2_MOUSE	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Transient receptor potential cation channel subfamily P member 2)	Mus musculus (Mouse)	aorta development [GO:0035904]; branching involved in ureteric bud morphogenesis [GO:0001658]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to osmotic stress [GO:0071470]; cilium organization [GO:0044782]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; embryonic placenta development [GO:0001892]; heart development [GO:0007507]; heart looping [GO:0001947]; intracellular calcium ion homeostasis [GO:0006874]; kidney development [GO:0001822]; liver development [GO:0001889]; mesonephric duct development [GO:0072177]; metanephric ascending thin limb development [GO:0072218]; metanephric cortex development [GO:0072214]; metanephric cortical collecting duct development [GO:0072219]; metanephric distal tubule development [GO:0072235]; metanephric mesenchyme development [GO:0072075]; metanephric part of ureteric bud development [GO:0035502]; metanephric S-shaped body morphogenesis [GO:0072284]; metanephric smooth muscle tissue development [GO:0072208]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neural tube development [GO:0021915]; placenta blood vessel development [GO:0060674]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein heterotetramerization [GO:0051290]; protein homotetramerization [GO:0051289]; protein tetramerization [GO:0051262]; regulation of calcium ion import [GO:0090279]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; release of sequestered calcium ion into cytosol [GO:0051209]; renal artery morphogenesis [GO:0061441]; renal tubule morphogenesis [GO:0061333]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; spinal cord development [GO:0021510]; transmembrane transport [GO:0055085]; Wnt signaling pathway [GO:0016055]	actinin binding [GO:0042805]; alpha-actinin binding [GO:0051393]; ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; channel activity [GO:0015267]; cytoskeletal protein binding [GO:0008092]; HLH domain binding [GO:0043398]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; outward rectifier potassium channel activity [GO:0015271]; phosphoprotein binding [GO:0051219]; potassium channel activity [GO:0005267]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; sodium channel activity [GO:0005272]; transcription regulator inhibitor activity [GO:0140416]; transmembrane transporter binding [GO:0044325]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]	basal cortex [GO:0045180]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cation channel complex [GO:0034703]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; migrasome [GO:0140494]; mitotic spindle [GO:0072686]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; polycystin complex [GO:0002133]; vesicle [GO:0031982]	GO:0001658; GO:0001822; GO:0001889; GO:0001892; GO:0001947; GO:0002133; GO:0003127; GO:0005102; GO:0005244; GO:0005245; GO:0005248; GO:0005249; GO:0005261; GO:0005262; GO:0005267; GO:0005272; GO:0005509; GO:0005737; GO:0005783; GO:0005789; GO:0005794; GO:0005829; GO:0005886; GO:0005929; GO:0006813; GO:0006814; GO:0006816; GO:0006874; GO:0007166; GO:0007204; GO:0007259; GO:0007368; GO:0007507; GO:0008092; GO:0009925; GO:0010628; GO:0015267; GO:0015271; GO:0016020; GO:0016055; GO:0016323; GO:0021510; GO:0021915; GO:0022843; GO:0030027; GO:0030659; GO:0031514; GO:0031982; GO:0034703; GO:0035502; GO:0035725; GO:0035904; GO:0036064; GO:0042127; GO:0042802; GO:0042803; GO:0042805; GO:0043398; GO:0044325; GO:0044782; GO:0045180; GO:0045429; GO:0045944; GO:0048763; GO:0050982; GO:0051117; GO:0051209; GO:0051219; GO:0051262; GO:0051289; GO:0051290; GO:0051371; GO:0051393; GO:0051726; GO:0055085; GO:0060170; GO:0060315; GO:0060674; GO:0061333; GO:0061441; GO:0070062; GO:0070588; GO:0071277; GO:0071320; GO:0071464; GO:0071470; GO:0071498; GO:0071805; GO:0071910; GO:0072075; GO:0072177; GO:0072208; GO:0072214; GO:0072218; GO:0072219; GO:0072235; GO:0072284; GO:0072686; GO:0090279; GO:0097730; GO:0098553; GO:0098554; GO:0140416; GO:0140494; GO:1900738; GO:2000134
GN012217	GN012217.1	B3EWZ5	31.2	516	526	5145	1.68e-63	228	MLRP1_ACRMI	MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN012225	GN012225.1	P34456	28.2	188	192	419	3.28e-19	87.4	YMD2_CAEEL	Uncharacterized protein F54H12.2	Caenorhabditis elegans	deoxyribonucleotide biosynthetic process [GO:0009263]	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]	cytosol [GO:0005829]	GO:0004748; GO:0005829; GO:0009263
GN012235	GN012235.1	O76554	23.7	355	451	548	8.34e-20	95.5	ACH4_CAEEL	Acetylcholine receptor subunit alpha-type des-2	Caenorhabditis elegans	calcium ion transport [GO:0006816]; excitatory postsynaptic potential [GO:0060079]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005230; GO:0005886; GO:0006816; GO:0007271; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0060079; GO:0098794; GO:1902495
GN012239	GN012239.1	P48181	28.9	305	358	493	7.86e-38	144	ACH2_CAEEL	Acetylcholine receptor subunit beta-type unc-29 (Uncoordinated protein 29)	Caenorhabditis elegans	calcium ion transport [GO:0006816]; locomotion [GO:0040011]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of locomotion involved in locomotory behavior [GO:0090326]; regulation of egg-laying behavior [GO:0046662]; regulation of membrane potential [GO:0042391]; regulation of muscle contraction [GO:0006937]; regulation of nematode pharyngeal pumping [GO:0043051]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0006937; GO:0007271; GO:0007274; GO:0014057; GO:0022848; GO:0030594; GO:0034220; GO:0040011; GO:0042391; GO:0043005; GO:0043025; GO:0043051; GO:0045202; GO:0045211; GO:0046662; GO:0090326
GN012241	GN012241.1	P19370	27.5	426	432	459	1.89e-33	134	ACHB2_CARAU	Neuronal acetylcholine receptor subunit beta-2 (GF-beta-2)	Carassius auratus (Goldfish)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; cognition [GO:0050890]; memory [GO:0007613]; nervous system process [GO:0050877]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]; visual learning [GO:0008542]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synaptic membrane [GO:0097060]	GO:0001666; GO:0005886; GO:0005892; GO:0007165; GO:0007271; GO:0007613; GO:0008542; GO:0015464; GO:0022848; GO:0035095; GO:0042166; GO:0045211; GO:0050877; GO:0050890; GO:0095500; GO:0097060
GN012242	GN012242.1	P43143	25.7	339	413	493	7.35e-33	132	ACHA6_RAT	Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Rat)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0014059; GO:0022848; GO:0030594; GO:0032991; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN012243	GN012243.1	P43679	27.9	312	459	455	1.37e-32	132	ACHB3_CHICK	Neuronal acetylcholine receptor subunit beta-3	Gallus gallus (Chicken)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098793; GO:0099171
GN012244	GN012244.1	Q8JFN7	33.3	234	352	572	1.78e-28	119	ACH91_ONCMY	Neuronal acetylcholine receptor subunit alpha-9-I (Nicotinic acetylcholine receptor subunit alpha-9-I) (NACHR alpha-9-I)	Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)		acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888]	postsynaptic membrane [GO:0045211]	GO:0004888; GO:0022848; GO:0045211
GN012245	GN012245.1	P43143	28.8	302	402	493	6.53e-42	157	ACHA6_RAT	Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Rat)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0014059; GO:0022848; GO:0030594; GO:0032991; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN012246	GN012246.1	Q9PTS8	29.7	290	422	484	9.07e-35	137	ACHA9_CHICK	Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0097060; GO:1902495
GN012250	GN012250.1	Q9DEN4	54.4	237	386	371	3.38e-66	217	FXD3A_XENLA	Forkhead box protein D3-A (FoxD3-A) (FoxD3a) (Fork head domain-related protein 6) (FKH-6) (Forkhead protein 6) (xFD-6) (xFKH6)	Xenopus laevis (African clawed frog)	anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; mesoderm formation [GO:0001707]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neurogenesis [GO:0050768]; neural crest cell fate commitment [GO:0014034]; positive regulation of neurogenesis [GO:0050769]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001707; GO:0003677; GO:0005634; GO:0006357; GO:0009653; GO:0014034; GO:0030154; GO:0045892; GO:0050768; GO:0050769
GN012253	GN012253.1	Q8TBB0	42.7	82	239	222	9.50e-13	68.6	THAP6_HUMAN	THAP domain-containing protein 6	Homo sapiens (Human)			microtubule cytoskeleton [GO:0015630]	GO:0015630
GN012257	GN012257.1	A0A2R8Q3S9	29.1	285	571	609	2.43e-22	104	CLCC1_DANRE	Chloride channel CLIC-like protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	endoplasmic reticulum calcium ion homeostasis [GO:0032469]; retina development in camera-type eye [GO:0060041]	chloride channel activity [GO:0005254]	endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nuclear membrane [GO:0031965]	GO:0000139; GO:0005254; GO:0005789; GO:0031965; GO:0032469; GO:0060041
GN012258	GN012258.1	F1NV61	33.1	163	397	309	1.34e-14	77.4	CASP7_CHICK	Caspase-7 (CASP-7) (EC 3.4.22.60) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]	Gallus gallus (Chicken)	apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; execution phase of apoptosis [GO:0097194]; lymphocyte apoptotic process [GO:0070227]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of plasma membrane repair [GO:1905686]; proteolysis [GO:0006508]	aspartic-type endopeptidase activity [GO:0004190]; cysteine-type endopeptidase activity [GO:0004197]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0003723; GO:0004190; GO:0004197; GO:0005576; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0042742; GO:0043525; GO:0070227; GO:0097194; GO:1905686
GN012262	GN012262.1	Q6DF62	48.2	139	139	299	7.39e-44	148	RGN_XENTR	Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	intracellular calcium ion homeostasis [GO:0006874]; L-ascorbic acid biosynthetic process [GO:0019853]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of calcium-mediated signaling [GO:0050848]	calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]; gluconolactonase activity [GO:0004341]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004341; GO:0005509; GO:0005634; GO:0005737; GO:0006874; GO:0008270; GO:0019853; GO:0030234; GO:0032781; GO:0050848
GN012264	GN012264.1	Q6TLF6	43.0	302	309	295	2.21e-77	241	RGN_DANRE	Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17)	Danio rerio (Zebrafish) (Brachydanio rerio)	intracellular calcium ion homeostasis [GO:0006874]; L-ascorbic acid biosynthetic process [GO:0019853]; positive regulation of ATP-dependent activity [GO:0032781]; regulation of calcium-mediated signaling [GO:0050848]	calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]; gluconolactonase activity [GO:0004341]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004341; GO:0005509; GO:0005634; GO:0005737; GO:0006874; GO:0008270; GO:0019853; GO:0030234; GO:0032781; GO:0050848
GN012265	GN012265.1	O60262	48.4	64	70	68	1.24e-13	62.0	GBG7_HUMAN	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	Homo sapiens (Human)	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]	G-protein beta-subunit binding [GO:0031681]	extracellular exosome [GO:0070062]; heterotrimeric G-protein complex [GO:0005834]; plasma membrane [GO:0005886]	GO:0005834; GO:0005886; GO:0007186; GO:0008277; GO:0031681; GO:0070062
GN012266	GN012266.1	Q95LI3	21.4	444	1271	801	3.24e-15	84.7	ZFY_BOVIN	Zinc finger Y-chromosomal protein	Bos taurus (Bovine)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0001228; GO:0005634; GO:0006357; GO:0046872
GN012267	GN012267.1	Q55GU0	35.3	300	610	916	1.51e-42	167	Y9955_DICDI	Probable serine/threonine-protein kinase DDB_G0267514 (EC 2.7.11.1)	Dictyostelium discoideum (Social amoeba)		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]		GO:0004674; GO:0005524; GO:0106310
GN012269	GN012269.1	Q93098	44.1	331	358	351	1.70e-95	291	WNT8B_HUMAN	Protein Wnt-8b	Homo sapiens (Human)	canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; determination of dorsal identity [GO:0048263]; gastrulation [GO:0007369]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; response to estradiol [GO:0032355]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]	extracellular region [GO:0005576]	GO:0005109; GO:0005125; GO:0005576; GO:0007165; GO:0007369; GO:0007399; GO:0030182; GO:0032355; GO:0032526; GO:0045165; GO:0048018; GO:0048263; GO:0060070; GO:0071300
GN012270	GN012270.1	P14600	31.9	307	400	407	1.90e-38	145	NK1R_RAT	Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1)	Rattus norvegicus (Rat)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; aggressive behavior [GO:0002118]; angiotensin-mediated drinking behavior [GO:0003051]; associative learning [GO:0008306]; behavioral response to pain [GO:0048266]; eating behavior [GO:0042755]; learning or memory [GO:0007611]; long-term memory [GO:0007616]; neuropeptide signaling pathway [GO:0007218]; operant conditioning [GO:0035106]; phospholipase C-activating tachykinin receptor signaling pathway [GO:0007209]; positive regulation of action potential [GO:0045760]; positive regulation of blood pressure [GO:0045777]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of hormone secretion [GO:0046887]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of ossification [GO:0045778]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of uterine smooth muscle contraction [GO:0070474]; positive regulation of vascular permeability [GO:0043117]; positive regulation of vasoconstriction [GO:0045907]; regulation of blood pressure [GO:0008217]; regulation of smooth muscle cell migration [GO:0014910]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of uterine smooth muscle contraction [GO:0070472]; response to auditory stimulus [GO:0010996]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to hormone [GO:0009725]; response to nicotine [GO:0035094]; response to ozone [GO:0010193]; response to pain [GO:0048265]; response to progesterone [GO:0032570]; smooth muscle contraction involved in micturition [GO:0060083]; sperm ejaculation [GO:0042713]; tachykinin receptor signaling pathway [GO:0007217]	substance P receptor activity [GO:0016496]	cell body [GO:0044297]; cell periphery [GO:0071944]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; sperm midpiece [GO:0097225]	GO:0002118; GO:0002687; GO:0003051; GO:0005769; GO:0005886; GO:0007189; GO:0007204; GO:0007209; GO:0007217; GO:0007218; GO:0007611; GO:0007616; GO:0008217; GO:0008306; GO:0009725; GO:0009986; GO:0010193; GO:0010634; GO:0010996; GO:0014910; GO:0016496; GO:0030425; GO:0032224; GO:0032230; GO:0032355; GO:0032570; GO:0035094; GO:0035106; GO:0036126; GO:0042713; GO:0042755; GO:0043117; GO:0044297; GO:0045211; GO:0045471; GO:0045760; GO:0045777; GO:0045778; GO:0045907; GO:0046887; GO:0048265; GO:0048266; GO:0048660; GO:0050671; GO:0050679; GO:0051496; GO:0051602; GO:0060083; GO:0061827; GO:0070472; GO:0070474; GO:0071944; GO:0097225; GO:1902093
GN012274	GN012274.1	O00463	32.0	153	339	557	1.14e-16	84.3	TRAF5_HUMAN	TNF receptor-associated factor 5 (RING finger protein 84)	Homo sapiens (Human)	CD40 signaling pathway [GO:0023035]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; interleukin-17-mediated signaling pathway [GO:0097400]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mRNA stabilization [GO:0048255]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	identical protein binding [GO:0042802]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; tumor necrosis factor receptor superfamily complex [GO:0002947]	GO:0002947; GO:0005164; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0006954; GO:0007165; GO:0007166; GO:0008270; GO:0008625; GO:0008630; GO:0009898; GO:0023035; GO:0031625; GO:0031996; GO:0033209; GO:0035591; GO:0035631; GO:0042802; GO:0042981; GO:0043122; GO:0043123; GO:0048255; GO:0061630; GO:0097400
GN012278	GN012278.1	P49003	30.6	333	349	452	3.43e-38	144	BMP5_MOUSE	Bone morphogenetic protein 5 (BMP-5)	Mus musculus (Mouse)	allantois development [GO:1905069]; anterior head development [GO:0097065]; BMP signaling pathway [GO:0030509]; cardiac muscle tissue development [GO:0048738]; cardiac septum morphogenesis [GO:0060411]; chorio-allantoic fusion [GO:0060710]; ear development [GO:0043583]; endocardial cushion formation [GO:0003272]; heart development [GO:0007507]; heart trabecula morphogenesis [GO:0061384]; hindbrain development [GO:0030902]; male genitalia development [GO:0030539]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of steroid biosynthetic process [GO:0010894]; neural fold elevation formation [GO:0021502]; pattern specification process [GO:0007389]; pericardium morphogenesis [GO:0003344]; pharyngeal system development [GO:0060037]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal system development [GO:0001501]; type B pancreatic cell development [GO:0003323]	BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]	extracellular region [GO:0005576]; vesicle [GO:0031982]	GO:0001501; GO:0003272; GO:0003323; GO:0003344; GO:0005125; GO:0005576; GO:0007389; GO:0007507; GO:0008083; GO:0008284; GO:0008285; GO:0010894; GO:0021502; GO:0030509; GO:0030539; GO:0030902; GO:0031982; GO:0032348; GO:0043569; GO:0043583; GO:0045944; GO:0048738; GO:0050679; GO:0060037; GO:0060391; GO:0060411; GO:0060710; GO:0061384; GO:0070700; GO:0097065; GO:1900006; GO:1905069; GO:2000065
GN012282	GN012282.1	Q4R744	27.9	340	1154	570	4.29e-25	115	HEAT9_MACFA	Protein HEATR9 (HEAT repeat-containing protein 9)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)				
GN012283	GN012283.1	Q9GUM2	52.7	220	222	383	9.00e-73	228	BRE4_CAEEL	Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.244) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT) (UDP-GalNAc:Glc-NAcbeta-R beta1,4-N-acetylgalactosaminyltransferase) (Cebeta4GalNAcT)	Caenorhabditis elegans	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; positive regulation of Notch signaling pathway [GO:0045747]; response to toxic substance [GO:0009636]	acetylgalactosaminyltransferase activity [GO:0008376]; N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0005794; GO:0005975; GO:0006688; GO:0008376; GO:0009101; GO:0009636; GO:0016020; GO:0033842; GO:0045747
GN012284	GN012284.1	Q96D70	38.4	177	271	268	3.71e-30	117	R3HD4_HUMAN	R3H domain-containing protein 4	Homo sapiens (Human)		nucleic acid binding [GO:0003676]	nucleus [GO:0005634]	GO:0003676; GO:0005634
GN012285	GN012285.1	Q9VDG5	37.3	890	858	950	3.09e-159	492	NACX_DROME	Sodium/calcium exchanger Calx (Na/Ca-exchange protein)	Drosophila melanogaster (Fruit fly)	neuromuscular process controlling posture [GO:0050884]; phototransduction [GO:0007602]; response to endoplasmic reticulum stress [GO:0034976]	calcium ion binding [GO:0005509]; calcium:sodium antiporter activity [GO:0005432]	plasma membrane [GO:0005886]; rhabdomere membrane [GO:0033583]	GO:0005432; GO:0005509; GO:0005886; GO:0007602; GO:0033583; GO:0034976; GO:0050884
GN012291	GN012291.1	Q8IYB5	64.6	130	434	467	1.08e-52	186	SMAP1_HUMAN	Stromal membrane-associated protein 1	Homo sapiens (Human)	regulation of clathrin-dependent endocytosis [GO:2000369]	clathrin binding [GO:0030276]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005096; GO:0005737; GO:0005886; GO:0030276; GO:0046872; GO:2000369
GN012292	GN012292.1	O35134	49.7	1728	1652	1717	0.0	1436	RPA1_MOUSE	DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194)	Mus musculus (Mouse)	negative regulation of protein localization to nucleolus [GO:1904750]; nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; rRNA transcription [GO:0009303]; transcription by RNA polymerase I [GO:0006360]; transcription elongation by RNA polymerase I [GO:0006362]	5'-3' RNA polymerase activity [GO:0034062]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]; DNA/RNA hybrid binding [GO:0071667]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]	GO:0000287; GO:0000785; GO:0001650; GO:0003677; GO:0003682; GO:0003899; GO:0005634; GO:0005654; GO:0005694; GO:0005736; GO:0006360; GO:0006362; GO:0008270; GO:0009303; GO:0034062; GO:0042790; GO:0071667; GO:1904750
GN012293	GN012293.1	Q7JK24	29.8	262	411	326	1.45e-27	114	B3GT1_GORGO	Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)	Gorilla gorilla gorilla (Western lowland gorilla)	glucosylceramide metabolic process [GO:0006678]; glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006678; GO:0008499; GO:0009101; GO:0009312
GN012294	GN012294.1	Q9U943	28.6	1142	4476	3380	3.47e-110	401	APLP_LOCMI	Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)]	Locusta migratoria (Migratory locust)	lipid transport [GO:0006869]	lipid carrier activity [GO:0005319]	extracellular region [GO:0005576]	GO:0005319; GO:0005576; GO:0006869
GN012295	GN012295.1	Q27403	43.1	334	557	504	2.09e-72	243	GCM_DROME	Transcription factor glial cells missing (Protein glide)	Drosophila melanogaster (Fruit fly)	dendrite morphogenesis [GO:0048813]; embryonic crystal cell differentiation [GO:0035165]; establishment of glial blood-brain barrier [GO:0060857]; glial cell development [GO:0021782]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; gliogenesis [GO:0042063]; hemocyte development [GO:0007516]; negative regulation of crystal cell differentiation [GO:0042690]; neuron differentiation [GO:0030182]; plasmatocyte differentiation [GO:0042387]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell differentiation [GO:0045687]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of transcription by RNA polymerase II [GO:0045944]; posterior head segmentation [GO:0035289]; regulation of gene expression [GO:0010468]; regulation of hemocyte differentiation [GO:0045610]; regulation of phagocytosis [GO:0050764]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal ganglion cell axon guidance [GO:0031290]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0003677; GO:0005634; GO:0006357; GO:0007403; GO:0007516; GO:0010001; GO:0010468; GO:0010628; GO:0021782; GO:0030182; GO:0031290; GO:0035165; GO:0035289; GO:0042063; GO:0042387; GO:0042690; GO:0045610; GO:0045687; GO:0045893; GO:0045944; GO:0048813; GO:0050764; GO:0060252; GO:0060857
GN012298	GN012298.1	P00428	35.6	90	173	129	1.04e-14	70.1	COX5B_BOVIN	Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide VIa) (Cytochrome c oxidase polypeptide Vb)	Bos taurus (Bovine)	mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]		mitochondrial inner membrane [GO:0005743]; respiratory chain complex IV [GO:0045277]	GO:0005743; GO:0006123; GO:0045277
GN012299	GN012299.1	Q4WZV3	25.2	222	663	844	7.07e-11	69.3	EGTA_ASPFU	Ergothioneine biosynthesis protein A [Includes: L-histidine N(alpha)-methyltransferase (EC 2.1.1.44); Hercynylcysteine S-oxide synthase (EC 1.21.3.10)]	Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)	selenoneine biosynthetic process [GO:1903257]	hercynylcysteine sulfoxide synthase activity [GO:0061686]; L-histidine N(alpha)-methyltransferase activity [GO:0052706]		GO:0052706; GO:0061686; GO:1903257
GN012300	GN012300.1	Q29RL9	53.6	304	303	301	9.76e-97	290	TCEA1_BOVIN	Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1)	Bos taurus (Bovine)	transcription elongation by RNA polymerase II [GO:0006368]	nucleic acid binding [GO:0003676]; transcription elongation factor activity [GO:0003711]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]	GO:0003676; GO:0003711; GO:0005654; GO:0006368; GO:0008270
GN012301	GN012301.1	Q9H8H0	23.8	525	520	719	2.11e-26	117	NOL11_HUMAN	Nucleolar protein 11	Homo sapiens (Human)	maturation of SSU-rRNA [GO:0030490]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455]	GO:0003723; GO:0005654; GO:0005730; GO:0030490; GO:0032040; GO:0034455; GO:1901838
GN012304	GN012304.1	Q96Q15	36.1	321	305	3661	1.41e-45	168	SMG1_HUMAN	Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1)	Homo sapiens (Human)	DNA damage response [GO:0006974]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein autophosphorylation [GO:0046777]; regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000622]; regulation of telomere maintenance [GO:0032204]	protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; telomeric repeat DNA binding [GO:0042162]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554]	GO:0000184; GO:0003723; GO:0004672; GO:0004674; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006406; GO:0006974; GO:0018105; GO:0032204; GO:0033391; GO:0042162; GO:0046777; GO:0046854; GO:0106310; GO:1902554; GO:2000622
GN012305	GN012305.1	Q8BKX6	39.4	3266	3290	3658	0.0	2174	SMG1_MOUSE	Serine/threonine-protein kinase SMG1 (SMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein autophosphorylation [GO:0046777]; regulation of telomere maintenance [GO:0032204]	diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; telomeric repeat DNA binding [GO:0042162]	chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554]	GO:0000184; GO:0004674; GO:0004697; GO:0005634; GO:0005654; GO:0005737; GO:0006974; GO:0018105; GO:0032204; GO:0033391; GO:0042162; GO:0046777; GO:0046854; GO:0106310; GO:1902554
GN012308	GN012308.1	Q9H8H0	23.8	525	520	719	2.11e-26	117	NOL11_HUMAN	Nucleolar protein 11	Homo sapiens (Human)	maturation of SSU-rRNA [GO:0030490]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; t-UTP complex [GO:0034455]	GO:0003723; GO:0005654; GO:0005730; GO:0030490; GO:0032040; GO:0034455; GO:1901838
GN012310	GN012310.1	A2A9C3	29.6	1380	1329	3431	7.43e-130	447	SZT2_MOUSE	KICSTOR complex protein SZT2 (Seizure threshold 2 protein) (Transcript increased in glutamate resistance) (TIGR)	Mus musculus (Mouse)	cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; central nervous system development [GO:0007417]; corpus callosum morphogenesis [GO:0021540]; negative regulation of TORC1 signaling [GO:1904262]; pigmentation [GO:0043473]; post-embryonic development [GO:0009791]; protein localization to lysosome [GO:0061462]; regulation of superoxide dismutase activity [GO:1901668]; response to nutrient levels [GO:0031667]		GATOR1 complex [GO:1990130]; GATOR2 complex [GO:0061700]; KICSTOR complex [GO:0140007]; lysosomal membrane [GO:0005765]; peroxisome [GO:0005777]	GO:0005765; GO:0005777; GO:0007417; GO:0009791; GO:0021540; GO:0031667; GO:0034198; GO:0042149; GO:0043473; GO:0061462; GO:0061700; GO:0140007; GO:1901668; GO:1904262; GO:1990130
GN012313	GN012313.1	Q58EG2	48.1	54	82	342	8.72e-09	53.5	ERLN1_DANRE	Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of fatty acid biosynthetic process [GO:0045717]; SREBP signaling pathway [GO:0032933]	cholesterol binding [GO:0015485]; ubiquitin protein ligase binding [GO:0031625]	endoplasmic reticulum membrane [GO:0005789]; protein-containing complex [GO:0032991]	GO:0005789; GO:0015485; GO:0031625; GO:0032933; GO:0032991; GO:0045541; GO:0045717
GN012315	GN012315.1	Q9ULI1	23.9	1776	1740	1742	1.03e-113	402	NWD2_HUMAN	NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239)	Homo sapiens (Human)			synapse [GO:0045202]	GO:0045202
GN012319	GN012319.1	B1AS42	37.0	297	330	316	1.51e-59	196	NB5R5_MOUSE	NADH-cytochrome b5 reductase-like (EC 1.6.2.2)	Mus musculus (Mouse)		cytochrome-b5 reductase activity, acting on NADH [GO:0090524]	endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005789; GO:0090524
GN012321	GN012321.1	Q99575	30.8	963	864	1024	1.49e-110	366	POP1_HUMAN	Ribonucleases P/MRP protein subunit POP1 (hPOP1)	Homo sapiens (Human)	RNA processing [GO:0006396]; tRNA 5'-leader removal [GO:0001682]; tRNA decay [GO:0016078]; tRNA processing [GO:0008033]	ribonuclease P RNA binding [GO:0033204]; RNA binding [GO:0003723]	extracellular region [GO:0005576]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]	GO:0000172; GO:0001682; GO:0003723; GO:0005576; GO:0005634; GO:0005654; GO:0005655; GO:0005730; GO:0006396; GO:0008033; GO:0016078; GO:0030681; GO:0033204
GN012322	GN012322.1	Q3MHR0	50.0	244	491	230	3.37e-70	226	LYPA1_BOVIN	Acyl-protein thioesterase 1 (APT-1) (EC 3.1.2.-) (Lysophospholipase 1) (Lysophospholipase I) (LPL-I) (LysoPLA I) (Palmitoyl-protein hydrolase) (EC 3.1.2.22)	Bos taurus (Bovine)	negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; protein depalmitoylation [GO:0002084]	glycerophospholipase activity [GO:0004620]; palmitoyl-(protein) hydrolase activity [GO:0008474]; phosphatidylcholine lysophospholipase A1 activity [GO:0004622]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0002084; GO:0004620; GO:0004622; GO:0005737; GO:0005783; GO:0005886; GO:0008474; GO:0031965; GO:0042997
GN012323	GN012323.1	Q9H841	51.4	109	213	383	6.21e-28	111	NPAL2_HUMAN	NIPA-like protein 2	Homo sapiens (Human)	magnesium ion transport [GO:0015693]	magnesium ion transmembrane transporter activity [GO:0015095]	membrane [GO:0016020]	GO:0015095; GO:0015693; GO:0016020
GN012324	GN012324.1	B0JZV4	50.3	747	1194	944	1.46e-233	696	CBPC5_XENTR	Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 5) (Protein deglutamylase CCP5)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	defense response to virus [GO:0051607]; proteolysis [GO:0006508]	metallocarboxypeptidase activity [GO:0004181]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]	GO:0004181; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0008270; GO:0015630; GO:0015631; GO:0030496; GO:0051607; GO:0072686
GN012325	GN012325.1	Q02508	34.2	500	582	510	8.06e-44	166	HGV2_HALRO	Protein HGV2	Halocynthia roretzi (Sea squirt) (Cynthia roretzi)	CENP-A containing chromatin assembly [GO:0034080]; DNA replication-dependent chromatin assembly [GO:0006335]	histone binding [GO:0042393]	nucleoplasm [GO:0005654]	GO:0005654; GO:0006335; GO:0034080; GO:0042393
GN012326	GN012326.1	Q6PC91	76.9	156	157	158	6.86e-70	211	BT3L4_DANRE	Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4)	Danio rerio (Zebrafish) (Brachydanio rerio)				
GN012328	GN012328.1	Q6P8Y1	41.1	209	209	208	1.30e-50	166	CAPSL_MOUSE	Calcyphosin-like protein	Mus musculus (Mouse)	angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; gene expression [GO:0010467]; retina development in camera-type eye [GO:0060041]; vasculogenesis [GO:0001570]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]	GO:0001525; GO:0001570; GO:0001935; GO:0005509; GO:0005737; GO:0010467; GO:0043542; GO:0060041
GN012329	GN012329.1	Q6PBD7	49.3	73	205	132	4.37e-15	72.0	ID2_XENTR	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cellular senescence [GO:0090398]; embryonic digestive tract morphogenesis [GO:0048557]; endodermal digestive tract morphogenesis [GO:0061031]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; positive regulation of blood pressure [GO:0045777]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of neuron differentiation [GO:0045664]	bHLH transcription factor binding [GO:0043425]; protein dimerization activity [GO:0046983]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000122; GO:0003714; GO:0005634; GO:0005737; GO:0010468; GO:0010628; GO:0010629; GO:0030182; GO:0032991; GO:0042752; GO:0043425; GO:0045664; GO:0045777; GO:0045893; GO:0046983; GO:0048557; GO:0048661; GO:0048663; GO:0061031; GO:0090398; GO:2000177
GN012330	GN012330.1	O15118	28.8	720	924	1278	9.99e-61	229	NPC1_HUMAN	NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein)	Homo sapiens (Human)	autophagy [GO:0006914]; bile acid metabolic process [GO:0008206]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol transport [GO:0030301]; establishment of protein localization to membrane [GO:0090150]; gene expression [GO:0010467]; glycoprotein biosynthetic process [GO:0009101]; intestinal cholesterol absorption [GO:0030299]; intracellular cholesterol transport [GO:0032367]; intracellular lipid transport [GO:0032365]; lysosomal transport [GO:0007041]; lysosome to ER cholesterol transport [GO:0090120]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell apoptotic process [GO:1904036]; negative regulation of TORC1 signaling [GO:1904262]; response to cadmium ion [GO:0046686]; sterol transport [GO:0015918]; symbiont entry into host cell [GO:0046718]	cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]	cytoplasmic side of lysosomal membrane [GO:0098574]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0004888; GO:0005576; GO:0005635; GO:0005764; GO:0005765; GO:0005783; GO:0005794; GO:0005886; GO:0006914; GO:0007041; GO:0008206; GO:0009101; GO:0010467; GO:0015485; GO:0015918; GO:0016020; GO:0030299; GO:0030301; GO:0031579; GO:0031902; GO:0032365; GO:0032367; GO:0033344; GO:0038023; GO:0042632; GO:0045121; GO:0046686; GO:0046718; GO:0048471; GO:0070062; GO:0090120; GO:0090150; GO:0098574; GO:0120020; GO:1904036; GO:1904262
GN012331	GN012331.1	Q96S53	45.4	496	627	571	2.51e-113	353	TESK2_HUMAN	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004672; GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006468; GO:0007283; GO:0030036; GO:0048041; GO:0106310
GN012332	GN012332.1	Q9HCJ3	26.2	423	845	691	1.94e-32	138	RAVR2_HUMAN	Ribonucleoprotein PTB-binding 2 (Protein raver-2)	Homo sapiens (Human)		RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005737
GN012336	GN012336.1	Q9W3T7	34.3	102	117	149	4.21e-12	62.0	BOUD_DROME	UPAR/Ly6 domain-containing protein bou (Protein boudin)	Drosophila melanogaster (Fruit fly)	regulation of synaptic transmission, cholinergic [GO:0032222]; regulation of tube architecture, open tracheal system [GO:0035152]; septate junction assembly [GO:0019991]; sleep [GO:0030431]		apicolateral plasma membrane [GO:0016327]; cell cortex [GO:0005938]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; septate junction [GO:0005918]	GO:0005576; GO:0005886; GO:0005918; GO:0005938; GO:0016327; GO:0019991; GO:0030431; GO:0032222; GO:0035152
GN012337	GN012337.1	Q6P1E1	63.7	449	913	1072	5.65e-169	523	ZMIZ1_MOUSE	Zinc finger MIZ domain-containing protein 1 (PIAS-like protein Zimp10) (Retinoic acid-induced protein 17)	Mus musculus (Mouse)	androgen receptor signaling pathway [GO:0030521]; artery morphogenesis [GO:0048844]; cellular senescence [GO:0090398]; developmental growth [GO:0048589]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pyramidal neuron migration to cerebral cortex [GO:0021852]; regulation of transcription by RNA polymerase II [GO:0006357]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vasculogenesis [GO:0001570]; vitellogenesis [GO:0007296]	SMAD binding [GO:0046332]; SUMO ligase activity [GO:0061665]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0001570; GO:0001701; GO:0003007; GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006357; GO:0007179; GO:0007296; GO:0008270; GO:0021852; GO:0030521; GO:0045582; GO:0045747; GO:0045944; GO:0046332; GO:0048146; GO:0048589; GO:0048844; GO:0060395; GO:0061665; GO:0090398
GN012338	GN012338.1	P97874	42.1	1378	1314	1305	0.0	950	GAK_RAT	Cyclin-G-associated kinase (EC 2.7.11.1)	Rattus norvegicus (Rat)	cell development [GO:0048468]; clathrin coat assembly [GO:0048268]; clathrin coat disassembly [GO:0072318]; clathrin-dependent endocytosis [GO:0072583]; endoplasmic reticulum organization [GO:0007029]; epidermal cell differentiation [GO:0009913]; establishment of skin barrier [GO:0061436]; forebrain morphogenesis [GO:0048853]; Golgi organization [GO:0007030]; Golgi to lysosome transport [GO:0090160]; intrahepatic bile duct development [GO:0035622]; negative regulation of neuron projection development [GO:0010977]; positive regulation of neural precursor cell proliferation [GO:2000179]; protein localization to Golgi apparatus [GO:0034067]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis [GO:0006898]; regulation of clathrin coat assembly [GO:1905443]	ATP binding [GO:0005524]; clathrin binding [GO:0030276]; cyclin binding [GO:0030332]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; vesicle [GO:0031982]	GO:0004674; GO:0005524; GO:0005794; GO:0005829; GO:0005925; GO:0006898; GO:0007029; GO:0007030; GO:0009913; GO:0010977; GO:0030136; GO:0030276; GO:0030332; GO:0031982; GO:0034067; GO:0035622; GO:0048268; GO:0048468; GO:0048471; GO:0048853; GO:0061436; GO:0072318; GO:0072583; GO:0072659; GO:0090160; GO:0106310; GO:1905443; GO:2000179
GN012339	GN012339.1	Q9JHW5	38.9	180	235	220	2.20e-35	128	VAMP7_RAT	Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1)	Rattus norvegicus (Rat)	calcium-ion regulated exocytosis [GO:0017156]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; endosome to lysosome transport [GO:0008333]; eosinophil degranulation [GO:0043308]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; natural killer cell degranulation [GO:0043320]; neutrophil degranulation [GO:0043312]; phagocytosis, engulfment [GO:0006911]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of histamine secretion by mast cell [GO:1903595]; regulation of protein targeting to vacuolar membrane [GO:1900483]; SNARE complex assembly [GO:0035493]; synaptic vesicle exocytosis [GO:0016079]; triglyceride transport [GO:0034197]; vesicle fusion [GO:0006906]; vesicle fusion with Golgi apparatus [GO:0048280]; vesicle transport along microtubule [GO:0047496]; vesicle-mediated transport [GO:0016192]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	apical part of cell [GO:0045177]; azurophil granule membrane [GO:0035577]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lamellipodium [GO:0030027]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; pseudopodium [GO:0031143]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; SNARE complex [GO:0031201]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]	GO:0000149; GO:0005484; GO:0005737; GO:0005765; GO:0005789; GO:0005794; GO:0005802; GO:0005886; GO:0006887; GO:0006888; GO:0006906; GO:0006911; GO:0008333; GO:0009986; GO:0016020; GO:0016079; GO:0016192; GO:0017156; GO:0030027; GO:0030133; GO:0030141; GO:0030175; GO:0030667; GO:0030670; GO:0030672; GO:0031091; GO:0031143; GO:0031201; GO:0031902; GO:0034197; GO:0035493; GO:0035577; GO:0043001; GO:0043005; GO:0043308; GO:0043312; GO:0043320; GO:0045177; GO:0045335; GO:0047496; GO:0048280; GO:0048471; GO:0050775; GO:0098686; GO:1900483; GO:1903595
GN012340	GN012340.1	Q5U4T7	44.2	938	986	970	9.53e-202	607	BIC1B_XENLA	Protein bicaudal C homolog 1-B (Bic-C-B)	Xenopus laevis (African clawed frog)	determination of left/right symmetry [GO:0007368]; mRNA catabolic process [GO:0006402]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]	GO:0003723; GO:0005737; GO:0006402; GO:0007368
GN012341	GN012341.1	Q9WTX8	34.3	537	729	717	8.65e-64	229	MD1L1_MOUSE	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1)	Mus musculus (Mouse)	attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; deactivation of mitotic spindle assembly checkpoint [GO:1902426]; mitotic spindle assembly checkpoint signaling [GO:0007094]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of metaphase plate congression [GO:0090235]; regulation of mitotic cell cycle phase transition [GO:1901990]; thymus development [GO:0048538]	identical protein binding [GO:0042802]; kinetochore binding [GO:0043515]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; MAD1 complex [GO:1990706]; mitotic spindle [GO:0072686]; mitotic spindle assembly checkpoint MAD1-MAD2 complex [GO:1990728]; mitotic spindle pole [GO:0097431]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	GO:0000776; GO:0000922; GO:0005634; GO:0005635; GO:0005654; GO:0005737; GO:0005813; GO:0007094; GO:0031965; GO:0042130; GO:0042802; GO:0043515; GO:0044615; GO:0048538; GO:0051315; GO:0072686; GO:0090235; GO:0090267; GO:0097431; GO:1901990; GO:1902426; GO:1990706; GO:1990728
GN012342	GN012342.1	Q91XQ5	31.0	381	411	561	5.02e-51	183	CHSTF_MOUSE	Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST)	Mus musculus (Mouse)	hexose biosynthetic process [GO:0019319]	3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity [GO:0050659]	Golgi membrane [GO:0000139]	GO:0000139; GO:0019319; GO:0050656; GO:0050659
GN012343	GN012343.1	Q9JKS4	47.3	74	1114	723	3.59e-11	71.2	LDB3_MOUSE	LIM domain-binding protein 3 (Protein cypher) (Protein oracle) (Z-band alternatively spliced PDZ-motif protein)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; heart development [GO:0007507]; muscle structure development [GO:0061061]; sarcomere organization [GO:0045214]	actin binding [GO:0003779]; cytoskeletal protein binding [GO:0008092]; enzyme binding [GO:0019899]; muscle alpha-actinin binding [GO:0051371]; protein kinase C binding [GO:0005080]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]; filamentous actin [GO:0031941]; perinuclear region of cytoplasm [GO:0048471]; pseudopodium [GO:0031143]; stress fiber [GO:0001725]; Z disc [GO:0030018]	GO:0001725; GO:0003779; GO:0005080; GO:0005856; GO:0005912; GO:0007507; GO:0008092; GO:0019899; GO:0030018; GO:0030036; GO:0031143; GO:0031941; GO:0045214; GO:0048471; GO:0051371; GO:0061061
GN012344	GN012344.1	P09481	36.3	215	294	496	3.50e-32	127	ACHA3_CHICK	Neuronal acetylcholine receptor subunit alpha-3	Gallus gallus (Chicken)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of appetite [GO:0032098]; response to nicotine [GO:0035094]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005783; GO:0005794; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0022848; GO:0030594; GO:0032098; GO:0034220; GO:0035094; GO:0035095; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060; GO:0098793; GO:0099171
GN012345	GN012345.1	E9Q238	43.7	183	1538	1360	1.36e-37	158	KANK1_MOUSE	KN motif and ankyrin repeat domains 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; cell population proliferation [GO:0008283]; cortical microtubule organization [GO:0043622]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell migration [GO:0030336]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lamellipodium morphogenesis [GO:2000393]; negative regulation of neuron projection development [GO:0010977]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of ruffle assembly [GO:1900028]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; podocyte cell migration [GO:0090521]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of wound healing [GO:0090303]; regulation of establishment of cell polarity [GO:2000114]; regulation of Rho protein signal transduction [GO:0035023]	beta-catenin binding [GO:0008013]; protein-macromolecule adaptor activity [GO:0030674]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	GO:0005634; GO:0005737; GO:0005856; GO:0005886; GO:0005938; GO:0008013; GO:0008283; GO:0010977; GO:0030036; GO:0030177; GO:0030336; GO:0030674; GO:0030837; GO:0032587; GO:0035023; GO:0035024; GO:0043622; GO:0046627; GO:0090263; GO:0090303; GO:0090521; GO:1900025; GO:1900028; GO:2000114; GO:2000393
GN012347	GN012347.1	Q3THK3	44.2	520	513	508	1.24e-62	216	T2FA_MOUSE	General transcription factor IIF subunit 1 (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha)	Mus musculus (Mouse)	negative regulation of protein binding [GO:0032091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; response to virus [GO:0009615]; transcription elongation by RNA polymerase II [GO:0006368]; transcription initiation at RNA polymerase II promoter [GO:0006367]	DNA binding [GO:0003677]; phosphatase activator activity [GO:0019211]; promoter-specific chromatin binding [GO:1990841]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase II general transcription initiation factor binding [GO:0001091]; TFIIF-class transcription factor complex binding [GO:0001096]	cell junction [GO:0030054]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIF complex [GO:0005674]	GO:0001091; GO:0001096; GO:0003677; GO:0005634; GO:0005654; GO:0005669; GO:0005674; GO:0006367; GO:0006368; GO:0009615; GO:0016251; GO:0019211; GO:0019903; GO:0019904; GO:0030054; GO:0032091; GO:0032968; GO:0032991; GO:0045944; GO:1990841
GN012348	GN012348.1	Q3T0J1	29.9	338	395	387	1.46e-43	159	FBX4_BOVIN	F-box only protein 4	Bos taurus (Bovine)	positive regulation of protein ubiquitination [GO:0031398]; protein polyubiquitination [GO:0000209]; regulation of protein stability [GO:0031647]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; telomere maintenance [GO:0000723]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005]	GO:0000209; GO:0000723; GO:0004842; GO:0005737; GO:0006511; GO:0019005; GO:0031146; GO:0031398; GO:0031647; GO:1990756
GN012349	GN012349.1	Q24155	29.5	95	315	226	3.07e-13	71.2	TRUNK_DROME	Protein trunk	Drosophila melanogaster (Fruit fly)	negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell differentiation [GO:0045596]; terminal region determination [GO:0007362]; torso signaling pathway [GO:0008293]	receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; torso binding [GO:0005122]	extracellular region [GO:0005576]	GO:0005102; GO:0005122; GO:0005576; GO:0007362; GO:0008293; GO:0030514; GO:0045596; GO:0048018
GN012351	GN012351.1	Q8C2E4	24.8	606	743	695	1.44e-43	171	PTCD1_MOUSE	Pentatricopeptide repeat-containing protein 1, mitochondrial	Mus musculus (Mouse)	mitochondrial RNA modification [GO:1900864]; tRNA 3'-end processing [GO:0042780]	rRNA binding [GO:0019843]; tRNA binding [GO:0000049]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0000049; GO:0005739; GO:0005759; GO:0019843; GO:0042780; GO:1900864
GN012353	GN012353.1	Q9CQZ5	49.5	111	125	131	9.84e-37	124	NDUA6_MOUSE	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Complex I-B14) (CI-B14) (NADH-ubiquinone oxidoreductase B14 subunit)	Mus musculus (Mouse)	aerobic respiration [GO:0009060]; mitochondrial respiratory chain complex I assembly [GO:0032981]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]		mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271]	GO:0005739; GO:0005743; GO:0009060; GO:0031966; GO:0032981; GO:0042776; GO:0045271
GN012356	GN012356.1	Q0P5C2	62.9	299	331	350	7.74e-130	377	MTDC_BOVIN	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]	Bos taurus (Bovine)	tetrahydrofolate interconversion [GO:0035999]	magnesium ion binding [GO:0000287]; methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NAD+) activity [GO:0004487]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; phosphate ion binding [GO:0042301]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0000287; GO:0004477; GO:0004487; GO:0004488; GO:0005739; GO:0005759; GO:0035999; GO:0042301
GN012357	GN012357.1	B2ZGJ1	51.4	607	685	637	2.88e-212	612	CLAT_DANRE	Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6)	Danio rerio (Zebrafish) (Brachydanio rerio)	acetylcholine biosynthetic process [GO:0008292]; locomotory behavior [GO:0007626]; neuromuscular synaptic transmission [GO:0007274]	choline O-acetyltransferase activity [GO:0004102]	cytoplasm [GO:0005737]; neuron projection [GO:0043005]; synapse [GO:0045202]	GO:0004102; GO:0005737; GO:0007274; GO:0007626; GO:0008292; GO:0043005; GO:0045202
GN012358	GN012358.1	O17444	55.5	499	551	578	3.60e-181	525	VACHT_DROME	Vesicular acetylcholine transporter (VAChT)	Drosophila melanogaster (Fruit fly)	chemical synaptic transmission [GO:0007268]	acetylcholine transmembrane transporter activity [GO:0005277]	AP-1 adaptor complex [GO:0030121]; AP-2 adaptor complex [GO:0030122]; terminal bouton [GO:0043195]	GO:0005277; GO:0007268; GO:0030121; GO:0030122; GO:0043195
GN012362	GN012362.1	Q93075	41.4	116	172	761	7.24e-28	112	TATD2_HUMAN	3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2)	Homo sapiens (Human)		hydrolase activity, acting on ester bonds [GO:0016788]	nucleoplasm [GO:0005654]	GO:0005654; GO:0016788
GN012363	GN012363.1	A6NMZ7	29.5	590	607	2263	5.10e-75	265	CO6A6_HUMAN	Collagen alpha-6(VI) chain	Homo sapiens (Human)	extracellular matrix organization [GO:0030198]		collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005589; GO:0030198; GO:0031012
GN012364	GN012364.1	Q4R803	54.8	294	397	357	7.53e-56	190	PPR42_MACFA	Protein phosphatase 1 regulatory subunit 42 (Leucine-rich repeat-containing protein 67)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)		actin binding [GO:0003779]; dynein complex binding [GO:0070840]; tubulin binding [GO:0015631]	centrosome [GO:0005813]; manchette [GO:0002177]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]	GO:0002177; GO:0003779; GO:0005813; GO:0005815; GO:0015630; GO:0015631; GO:0070840
GN012365	GN012365.1	B2RX88	36.4	645	1845	1205	3.83e-31	137	CSPP1_MOUSE	Centrosome and spindle pole associated protein 1	Mus musculus (Mouse)	positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467]	identical protein binding [GO:0042802]	centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; spindle [GO:0005819]; spindle pole [GO:0000922]	GO:0000922; GO:0005654; GO:0005813; GO:0005819; GO:0005874; GO:0005929; GO:0032467; GO:0034451; GO:0036064; GO:0042802; GO:0051781
GN012367	GN012367.1	Q9D531	42.2	135	213	156	1.33e-36	128	NXNL2_MOUSE	Nucleoredoxin-like protein 2 (Rod-derived cone viability factor 2) (RdCVF2)	Mus musculus (Mouse)	photoreceptor cell maintenance [GO:0045494]; sensory perception of smell [GO:0007608]; visual perception [GO:0007601]			GO:0007601; GO:0007608; GO:0045494
GN012368	GN012368.1	Q9P217	53.8	1143	1173	1185	0.0	1137	ZSWM5_HUMAN	Zinc finger SWIM domain-containing protein 5	Homo sapiens (Human)		zinc ion binding [GO:0008270]	Cul2-RING ubiquitin ligase complex [GO:0031462]; extracellular region [GO:0005576]	GO:0005576; GO:0008270; GO:0031462
GN012369	GN012369.1	Q6NRX3	31.2	237	616	545	1.27e-26	117	ADIPB_XENLA	Afadin- and alpha-actinin-binding protein B (ADIP-B) (Afadin DIL domain-interacting protein B) (SSX2-interacting protein B)	Xenopus laevis (African clawed frog)	centrosome cycle [GO:0007098]; intraciliary transport involved in cilium assembly [GO:0035735]	microtubule minus-end binding [GO:0051011]	adherens junction [GO:0005912]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]	GO:0005912; GO:0007098; GO:0034451; GO:0035735; GO:0036064; GO:0051011
GN012372	GN012372.1	Q92889	55.9	893	869	916	0.0	929	XPF_HUMAN	DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein)	Homo sapiens (Human)	cellular response to UV [GO:0034644]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; mitotic recombination [GO:0006312]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of telomere maintenance [GO:0032205]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair involved in interstrand cross-link repair [GO:1901255]; resolution of meiotic recombination intermediates [GO:0000712]; response to UV [GO:0009411]; telomere maintenance [GO:0000723]; telomeric DNA-containing double minutes formation [GO:0061819]	damaged DNA binding [GO:0003684]; DNA endonuclease activity [GO:0004520]; identical protein binding [GO:0042802]; promoter-specific chromatin binding [GO:1990841]; protein-macromolecule adaptor activity [GO:0030674]; single-stranded DNA binding [GO:0003697]; single-stranded DNA endonuclease activity [GO:0000014]; TFIID-class transcription factor complex binding [GO:0001094]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; ERCC4-ERCC1 complex [GO:0070522]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 1 complex [GO:0000110]; nucleus [GO:0005634]	GO:0000014; GO:0000109; GO:0000110; GO:0000712; GO:0000723; GO:0000724; GO:0000781; GO:0001094; GO:0003684; GO:0003697; GO:0004520; GO:0005634; GO:0005654; GO:0005694; GO:0006281; GO:0006289; GO:0006303; GO:0006312; GO:0009411; GO:0016604; GO:0030674; GO:0032205; GO:0034644; GO:0042802; GO:0061819; GO:0070522; GO:1901255; GO:1904357; GO:1905765; GO:1990841
GN012373	GN012373.1	Q9JI13	32.6	484	620	469	1.47e-57	204	SAS10_MOUSE	Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (Crl-1) (Disrupter of silencing SAS10) (UTP3 homolog)	Mus musculus (Mouse)	brain development [GO:0007420]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]		nucleolus [GO:0005730]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]	GO:0000462; GO:0005634; GO:0005730; GO:0007420; GO:0032040; GO:0042274
GN012374	GN012374.1	Q9HAR2	33.7	489	770	1447	4.83e-61	227	AGRL3_HUMAN	Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; excitatory synapse assembly [GO:1904861]; G protein-coupled receptor signaling pathway [GO:0007186]; neuron migration [GO:0001764]; Rho-activating G protein-coupled receptor signaling pathway [GO:0160221]; synapse assembly [GO:0007416]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; cell adhesion mediator activity [GO:0098631]; G protein-coupled receptor activity [GO:0004930]; molecular condensate scaffold activity [GO:0140693]	anchoring junction [GO:0070161]; axon [GO:0030424]; cell-cell junction [GO:0005911]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0001764; GO:0004930; GO:0005509; GO:0005886; GO:0005911; GO:0007166; GO:0007186; GO:0007189; GO:0007416; GO:0016020; GO:0030246; GO:0030424; GO:0045211; GO:0070161; GO:0098609; GO:0098631; GO:0098978; GO:0140693; GO:0160221; GO:1904861
GN012375	GN012375.1	E9PYQ0	49.6	575	863	876	4.32e-97	326	RS10B_MOUSE	Radial spoke head 10 homolog B	Mus musculus (Mouse)			9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cilium [GO:0005929]; sperm flagellum [GO:0036126]	GO:0005929; GO:0005930; GO:0036126; GO:0097729
GN012376	GN012376.1	Q06806	46.5	245	246	1134	7.30e-70	235	TIE1_MOUSE	Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1)	Mus musculus (Mouse)	aortic valve morphogenesis [GO:0003180]; blood vessel development [GO:0001568]; branching involved in lymph vessel morphogenesis [GO:0060854]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; endothelial cell migration [GO:0043542]; in utero embryonic development [GO:0001701]; lymphatic endothelial cell differentiation [GO:0060836]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; positive regulation of angiogenesis [GO:0045766]; regulation of endothelial cell proliferation [GO:0001936]; regulation of extracellular matrix assembly [GO:1901201]; response to retinoic acid [GO:0032526]; tissue remodeling [GO:0048771]; vasculogenesis [GO:0001570]	ATP binding [GO:0005524]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]	membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001568; GO:0001570; GO:0001701; GO:0001936; GO:0003180; GO:0004714; GO:0005524; GO:0005886; GO:0007169; GO:0016020; GO:0016525; GO:0030336; GO:0032526; GO:0043235; GO:0043542; GO:0045766; GO:0048771; GO:0060836; GO:0060854; GO:1901201
GN012377	GN012377.1	Q17RR3	45.7	245	339	467	3.69e-56	192	LIPR3_HUMAN	Pancreatic lipase-related protein 3 (PL-RP3) (EC 3.1.1.3)	Homo sapiens (Human)	cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; triglyceride catabolic process [GO:0019433]	glycerophospholipid phospholipase A1 activity [GO:0008970]; lipoprotein lipase activity [GO:0004465]	extracellular region [GO:0005576]	GO:0004465; GO:0005576; GO:0006633; GO:0008970; GO:0019433; GO:0034375; GO:0042632
GN012378	GN012378.1	P06857	45.8	251	348	467	1.07e-67	223	LIPR1_CANLF	Inactive pancreatic lipase-related protein 1 (PL-RP1)	Canis lupus familiaris (Dog) (Canis familiaris)	lipid metabolic process [GO:0006629]	calcium ion binding [GO:0005509]; carboxylic ester hydrolase activity [GO:0052689]	extracellular region [GO:0005576]	GO:0005509; GO:0005576; GO:0006629; GO:0052689
GN012380	GN012380.1	Q6P8U6	41.4	350	350	465	1.10e-81	259	LIPP_MOUSE	Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3)	Mus musculus (Mouse)	cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; positive regulation of triglyceride lipase activity [GO:0061365]; post-embryonic development [GO:0009791]; retinoid metabolic process [GO:0001523]; triglyceride catabolic process [GO:0019433]	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; glycerophospholipid phospholipase A1 activity [GO:0008970]; lipase activity [GO:0016298]; lipoprotein lipase activity [GO:0004465]; retinyl-palmitate esterase activity [GO:0050253]; triacylglycerol lipase activity [GO:0004806]	extracellular region [GO:0005576]	GO:0001523; GO:0004465; GO:0004806; GO:0005576; GO:0006629; GO:0006633; GO:0008970; GO:0009791; GO:0016298; GO:0019433; GO:0030299; GO:0034375; GO:0042632; GO:0047376; GO:0050253; GO:0061365
GN012383	GN012383.1	Q5FW38	49.3	69	240	462	9.73e-09	58.5	NFIL3_XENTR	Nuclear factor interleukin-3-regulated protein	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	circadian rhythm [GO:0007623]; immune response [GO:0006955]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0006355; GO:0006366; GO:0006955; GO:0007623; GO:0045892
GN012384	GN012384.1	Q80Y17	47.2	883	1044	1036	5.69e-258	756	L2GL1_MOUSE	Lethal(2) giant larvae protein homolog 1 (LLGL) (Mgl-1) (Mlgl)	Mus musculus (Mouse)	axonogenesis [GO:0007409]; brain development [GO:0007420]; cortical actin cytoskeleton organization [GO:0030866]; establishment of spindle orientation [GO:0051294]; Golgi to plasma membrane transport [GO:0006893]; maintenance of apical/basal cell polarity [GO:0035090]; protein-containing complex assembly [GO:0065003]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of Notch signaling pathway [GO:0008593]	GTPase activator activity [GO:0005096]; myosin II binding [GO:0045159]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]	axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; early endosome membrane [GO:0031901]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; myelin sheath abaxonal region [GO:0035748]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	GO:0000137; GO:0000139; GO:0005096; GO:0005737; GO:0005856; GO:0005886; GO:0006893; GO:0007409; GO:0007420; GO:0008593; GO:0016323; GO:0019901; GO:0030424; GO:0030864; GO:0030866; GO:0031267; GO:0031901; GO:0032588; GO:0032878; GO:0035090; GO:0035748; GO:0045159; GO:0051294; GO:0065003
GN012387	GN012387.1	Q47944	37.2	557	577	531	1.17e-93	300	SDH_GLUOY	L-sorbose 1-dehydrogenase (SDH) (EC 1.1.99.32)	Gluconobacter oxydans (Gluconobacter suboxydans)		flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on CH-OH group of donors [GO:0016614]		GO:0016614; GO:0050660
GN012390	GN012390.1	Q68F72	37.4	478	563	569	5.64e-94	301	S15A4_XENLA	Solute carrier family 15 member 4	Xenopus laevis (African clawed frog)	dipeptide import across plasma membrane [GO:0140206]; mast cell homeostasis [GO:0033023]; peptidoglycan transport [GO:0015835]; positive regulation of innate immune response [GO:0045089]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; positive regulation of toll-like receptor 8 signaling pathway [GO:0034161]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; regulation of isotype switching to IgG isotypes [GO:0048302]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]	dipeptide transmembrane transporter activity [GO:0071916]; L-histidine transmembrane transporter activity [GO:0005290]; peptide:proton symporter activity [GO:0015333]; peptidoglycan transmembrane transporter activity [GO:0015647]	early endosome membrane [GO:0031901]; endolysosome membrane [GO:0036020]; lysosomal membrane [GO:0005765]	GO:0005290; GO:0005765; GO:0015333; GO:0015647; GO:0015835; GO:0031901; GO:0033023; GO:0034157; GO:0034161; GO:0034165; GO:0036020; GO:0045089; GO:0048302; GO:0070424; GO:0070430; GO:0070434; GO:0071916; GO:0140206
GN012391	GN012391.1	Q80T11	29.0	496	486	461	7.59e-40	152	USH1G_MOUSE	pre-mRNA splicing regulator USH1G (Jackson shaker protein) (Scaffold protein containing ankyrin repeats and SAM domain) (Usher syndrome type-1G protein homolog)	Mus musculus (Mouse)	equilibrioception [GO:0050957]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell differentiation [GO:0060113]; inner ear receptor cell stereocilium organization [GO:0060122]; photoreceptor cell maintenance [GO:0045494]; regulation of clathrin-dependent endocytosis [GO:2000369]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	identical protein binding [GO:0042802]; spectrin binding [GO:0030507]	actin cytoskeleton [GO:0015629]; Cajal body [GO:0015030]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; photoreceptor cell cilium [GO:0097733]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]	GO:0001917; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0007605; GO:0015030; GO:0015629; GO:0016020; GO:0016607; GO:0030507; GO:0032391; GO:0036064; GO:0042472; GO:0042802; GO:0045494; GO:0050953; GO:0050957; GO:0060113; GO:0060122; GO:0097546; GO:0097733; GO:2000369
GN012393	GN012393.1	Q14AM7	48.4	279	266	275	1.26e-44	154	HAPR1_MOUSE	HUWE1-associated protein modifying stress responses	Mus musculus (Mouse)	negative regulation of signal transduction by p53 class mediator [GO:1901797]; regulation of cellular response to stress [GO:0080135]	ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0031625; GO:0080135; GO:1901797
GN012394	GN012394.1	Q93009	62.6	1070	1068	1102	0.0	1394	UBP7_HUMAN	Ubiquitin C-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; DNA alkylation repair [GO:0006307]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of TORC1 signaling [GO:1904262]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; regulation of establishment of protein localization to telomere [GO:0070203]; regulation of protein stability [GO:0031647]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of telomere capping [GO:1904353]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; symbiont-mediated disruption of host cell PML body [GO:0075342]; transcription-coupled nucleotide-excision repair [GO:0006283]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]; histone H2A deubiquitinase activity [GO:0140950]; histone H2B deubiquitinase activity [GO:0140936]; K48-linked deubiquitinase activity [GO:1990380]; p53 binding [GO:0002039]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peptidase complex [GO:1905368]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0002039; GO:0004197; GO:0004843; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005829; GO:0006283; GO:0006307; GO:0010803; GO:0016567; GO:0016579; GO:0016604; GO:0016605; GO:0031647; GO:0032435; GO:0032991; GO:0035520; GO:0042752; GO:0044027; GO:0045721; GO:0050821; GO:0070203; GO:0070536; GO:0071108; GO:0075342; GO:0101005; GO:0140374; GO:0140936; GO:0140950; GO:1901796; GO:1904262; GO:1904353; GO:1905279; GO:1905368; GO:1990380
GN012395	GN012395.1	Q5XHC1	51.6	312	313	307	9.81e-101	301	CFA96_XENLA	Cilia-and flagella-associated protein 96	Xenopus laevis (African clawed frog)			centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]	GO:0005813; GO:0005881
GN012396	GN012396.1	Q9W6K1	61.6	523	673	711	3.55e-226	649	MRE11_XENLA	Double-strand break repair protein MRE11 (EC 3.1.-.-)	Xenopus laevis (African clawed frog)	DNA damage response [GO:0006974]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; meiotic DNA double-strand break formation [GO:0042138]; metaphase chromosome alignment [GO:0051310]; mitochondrial double-strand break repair via homologous recombination [GO:0097552]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; R-loop processing [GO:0062176]; telomere maintenance [GO:0000723]	3'-5' exonuclease activity [GO:0008408]; 3'-5'-DNA exonuclease activity [GO:0008296]; DNA endonuclease activity [GO:0004520]; manganese ion binding [GO:0030145]; single-stranded DNA endonuclease activity [GO:0000014]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; Mre11 complex [GO:0030870]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]	GO:0000014; GO:0000723; GO:0000724; GO:0000781; GO:0004520; GO:0005634; GO:0005657; GO:0005694; GO:0006303; GO:0006974; GO:0007095; GO:0008296; GO:0008408; GO:0030145; GO:0030870; GO:0031573; GO:0035861; GO:0042138; GO:0051310; GO:0062176; GO:0097552; GO:0110025; GO:2001033
GN012397	GN012397.1	O60763	50.3	939	937	962	5.71e-269	778	USO1_HUMAN	General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein)	Homo sapiens (Human)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi vesicle docking [GO:0048211]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; transcytosis [GO:0045056]; vesicle fusion with Golgi apparatus [GO:0048280]	cadherin binding [GO:0045296]; RNA binding [GO:0003723]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; perinuclear region of cytoplasm [GO:0048471]; transport vesicle [GO:0030133]	GO:0000139; GO:0003723; GO:0005783; GO:0005794; GO:0005815; GO:0005829; GO:0006886; GO:0006888; GO:0012507; GO:0016020; GO:0030133; GO:0045056; GO:0045296; GO:0048211; GO:0048280; GO:0048471; GO:0061025
GN012398	GN012398.1	A1L2I9	32.0	631	627	679	2.36e-94	307	T214B_XENLA	Transmembrane protein 214-B	Xenopus laevis (African clawed frog)			endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	GO:0005783; GO:0005789; GO:0005794
GN012399	GN012399.1	Q8N6T3	39.8	477	511	406	7.77e-84	268	ARFG1_HUMAN	ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)	Homo sapiens (Human)	regulation of ARF protein signal transduction [GO:0032012]; regulation of endocytosis [GO:0030100]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; synapse [GO:0045202]	GO:0000139; GO:0005096; GO:0005829; GO:0030100; GO:0032012; GO:0045202
GN012401	GN012401.1	Q0V9X5	85.7	77	218	296	1.17e-34	127	BHE22_XENTR	Class E basic helix-loop-helix protein 22 (bHLHe22) (Class B basic helix-loop-helix protein 5) (bHLHb5)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	axon development [GO:0061564]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]	nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0007423; GO:0045944; GO:0046983; GO:0061564; GO:0070888
GN012402	GN012402.1	O60306	67.6	1357	1412	1485	0.0	1862	AQR_HUMAN	RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160)	Homo sapiens (Human)	mRNA splicing, via spliceosome [GO:0000398]	3'-5' RNA helicase activity [GO:0034458]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000398; GO:0003723; GO:0003727; GO:0005634; GO:0005654; GO:0005681; GO:0016020; GO:0016887; GO:0034458; GO:0071006; GO:0071007; GO:0071013; GO:0071014; GO:0071020
GN012403	GN012403.1	Q58CR3	41.0	585	608	579	9.23e-124	380	EIF2D_BOVIN	Eukaryotic translation initiation factor 2D (eIF2d) (Ligatin)	Bos taurus (Bovine)	formation of translation preinitiation complex [GO:0001731]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]	GO:0001731; GO:0003723; GO:0003743; GO:0005737
GN012404	GN012404.1	Q9C093	35.5	1954	1908	1822	1.89e-301	923	SPEF2_HUMAN	Sperm flagella and cilia-associated protein 2 (Protein KPL2) (Sperm flagellar protein 2)	Homo sapiens (Human)	brain morphogenesis [GO:0048854]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; respiratory system development [GO:0060541]; skeletal system morphogenesis [GO:0048705]; sperm axoneme assembly [GO:0007288]; spermatogenesis [GO:0007283]		axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; manchette [GO:0002177]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]	GO:0002177; GO:0003351; GO:0005576; GO:0005737; GO:0005794; GO:0005929; GO:0005930; GO:0007283; GO:0007288; GO:0036126; GO:0048705; GO:0048854; GO:0060541; GO:0097225
GN012405	GN012405.1	P47245	41.4	949	1027	1161	4.63e-246	729	NRDC_RAT	Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase)	Rattus norvegicus (Rat)	negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of axonogenesis [GO:0050772]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of myelination [GO:0031643]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteolysis [GO:0006508]	endopeptidase activator activity [GO:0061133]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]	dendrite [GO:0030425]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004222; GO:0005739; GO:0005759; GO:0006508; GO:0008233; GO:0030425; GO:0031643; GO:0032760; GO:0046872; GO:0050772; GO:0051044; GO:0061133; GO:0120163; GO:1903265
GN012408	GN012408.1	Q91312	37.0	100	183	173	1.85e-13	68.2	CRYAB_AQUCT	Alpha-crystallin B chain (Alpha(B)-crystallin)	Aquarana catesbeiana (American bullfrog) (Rana catesbeiana)	negative regulation of apoptotic process [GO:0043066]; protein refolding [GO:0042026]; response to heat [GO:0009408]	protein homodimerization activity [GO:0042803]; structural constituent of eye lens [GO:0005212]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005212; GO:0005634; GO:0005737; GO:0009408; GO:0042026; GO:0042803; GO:0043066
GN012409	GN012409.1	Q91312	37.0	100	183	173	1.85e-13	68.2	CRYAB_AQUCT	Alpha-crystallin B chain (Alpha(B)-crystallin)	Aquarana catesbeiana (American bullfrog) (Rana catesbeiana)	negative regulation of apoptotic process [GO:0043066]; protein refolding [GO:0042026]; response to heat [GO:0009408]	protein homodimerization activity [GO:0042803]; structural constituent of eye lens [GO:0005212]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005212; GO:0005634; GO:0005737; GO:0009408; GO:0042026; GO:0042803; GO:0043066
GN012410	GN012410.1	O43451	41.1	2656	2619	2753	0.0	1910	MGA_HUMAN	Maltase-glucoamylase (Alpha-1,4-glucosidase) (EC 3.2.1.20)	Homo sapiens (Human)	dextrin catabolic process [GO:1901027]; maltose catabolic process [GO:0000025]; starch catabolic process [GO:0005983]	alpha-1,4-glucosidase activity [GO:0004558]; amylase activity [GO:0016160]; carbohydrate binding [GO:0030246]; catalytic activity [GO:0003824]; oligo-1,6-glucosidase activity [GO:0004574]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]	GO:0000025; GO:0003824; GO:0004558; GO:0004574; GO:0005886; GO:0005983; GO:0016160; GO:0016324; GO:0030246; GO:0070062; GO:0070821; GO:0101003; GO:1901027
GN012411	GN012411.1	Q6NXW6	45.6	531	633	688	4.75e-142	432	RAD17_MOUSE	Cell cycle checkpoint protein RAD17	Mus musculus (Mouse)	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; negative regulation of DNA replication [GO:0008156]; protein localization to site of double-strand break [GO:1990166]; regulation of phosphorylation [GO:0042325]	chromatin-protein adaptor activity [GO:0140463]; DNA clamp loader activity [GO:0003689]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, telomeric repeat region [GO:0140445]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad17 RFC-like complex [GO:0031389]; site of double-strand break [GO:0035861]	GO:0000785; GO:0003689; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0006281; GO:0006974; GO:0008156; GO:0031389; GO:0031573; GO:0033314; GO:0035861; GO:0042325; GO:0140445; GO:0140463; GO:1990166
GN012412	GN012412.1	Q0V9J0	46.6	148	264	253	1.67e-29	114	TMM69_XENTR	Transmembrane protein 69	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			membrane [GO:0016020]	GO:0016020
GN012413	GN012413.1	O62742	49.8	436	429	547	1.43e-134	400	SCP2_RABIT	Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (SCPX) (Sterol carrier protein X) (SCP-X)	Oryctolagus cuniculus (Rabbit)	bile acid metabolic process [GO:0008206]; fatty acid beta-oxidation [GO:0006635]; intracellular cholesterol transport [GO:0032367]; regulation of lipid metabolic process [GO:0019216]; regulation of phospholipid biosynthetic process [GO:0071071]; sterol transport [GO:0015918]	acetyl-CoA C-acyltransferase activity [GO:0003988]; acetyl-CoA C-myristoyltransferase activity [GO:0050633]; cholesterol transfer activity [GO:0120020]; phosphatidylcholine transfer activity [GO:0120019]; propanoyl-CoA C-acyltransferase activity [GO:0033814]; propionyl-CoA C2-trimethyltridecanoyltransferase activity [GO:0050632]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0003988; GO:0005737; GO:0005739; GO:0005777; GO:0005782; GO:0005783; GO:0006635; GO:0008206; GO:0015918; GO:0019216; GO:0032367; GO:0033814; GO:0050632; GO:0050633; GO:0071071; GO:0120019; GO:0120020
GN012414	GN012414.1	Q6PAY8	60.9	419	418	417	2.73e-176	501	HSDL2_XENLA	Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-)	Xenopus laevis (African clawed frog)			mitochondrion [GO:0005739]; peroxisome [GO:0005777]	GO:0005739; GO:0005777
GN012415	GN012415.1	Q17Q97	34.3	143	172	180	3.32e-18	80.5	REX1B_BOVIN	Required for excision 1-B domain-containing protein	Bos taurus (Bovine)				
GN012416	GN012416.1	O42227	83.0	400	461	480	2.43e-246	683	HDA1B_XENLA	Probable histone deacetylase 1-B (HD1-B) (EC 3.5.1.98) (Protein deacetylase HDAC1-B) (EC 3.5.1.-) (Protein decrotonylase HDAC1-B) (EC 3.5.1.-) (RPD3 homolog)	Xenopus laevis (African clawed frog)	heterochromatin formation [GO:0031507]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase activity [GO:0004407]; histone deacetylase activity, hydrolytic mechanism [GO:0141221]; histone decrotonylase activity [GO:0160009]; protein decrotonylase activity [GO:0160008]; protein lysine deacetylase activity [GO:0033558]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; NuRD complex [GO:0016581]	GO:0004407; GO:0005634; GO:0005737; GO:0016581; GO:0031507; GO:0033558; GO:0140297; GO:0141221; GO:0160008; GO:0160009
GN012417	GN012417.1	Q7ZUX6	55.3	304	308	305	1.09e-105	313	DOHH_DANRE	Deoxyhypusine hydroxylase (DOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase)	Danio rerio (Zebrafish) (Brachydanio rerio)	peptidyl-hypusine biosynthetic process [GO:0008612]	deoxyhypusine monooxygenase activity [GO:0019135]; iron ion binding [GO:0005506]		GO:0005506; GO:0008612; GO:0019135
GN012418	GN012418.1	Q96LT7	28.4	476	486	481	4.98e-50	181	CI072_HUMAN	Guanine nucleotide exchange factor C9orf72	Homo sapiens (Human)	autophagosome-lysosome fusion [GO:0061909]; autophagy [GO:0006914]; axon extension [GO:0048675]; endocytosis [GO:0006897]; late endosome to lysosome transport [GO:1902774]; negative regulation of exocytosis [GO:0045920]; negative regulation of immune response [GO:0050777]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of macroautophagy [GO:0016239]; regulation of actin filament organization [GO:0110053]; regulation of autophagosome assembly [GO:2000785]; regulation of autophagy [GO:0010506]; regulation of protein localization [GO:0032880]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of TORC1 signaling [GO:1903432]; stress granule assembly [GO:0034063]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	autolysosome [GO:0044754]; autophagosome [GO:0005776]; axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; guanyl-nucleotide exchange factor complex [GO:0032045]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lysosome [GO:0005764]; main axon [GO:0044304]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; P-body [GO:0000932]; perikaryon [GO:0043204]; postsynapse [GO:0098794]; presynapse [GO:0098793]; presynaptic cytosol [GO:0099523]	GO:0000932; GO:0001933; GO:0005085; GO:0005096; GO:0005576; GO:0005634; GO:0005737; GO:0005764; GO:0005768; GO:0005776; GO:0005829; GO:0006897; GO:0006914; GO:0010494; GO:0010506; GO:0016239; GO:0030425; GO:0031267; GO:0031965; GO:0032045; GO:0032880; GO:0034063; GO:0043204; GO:0044295; GO:0044304; GO:0044754; GO:0045920; GO:0048675; GO:0050777; GO:0061909; GO:0098686; GO:0098693; GO:0098793; GO:0098794; GO:0098978; GO:0099523; GO:0110053; GO:1902774; GO:1903432; GO:2000785
GN012420	GN012420.1	Q96DM3	55.6	655	656	657	3.13e-252	713	RMC1_HUMAN	Regulator of MON1-CCZ1 complex (Colon cancer-associated protein Mic1) (Mic-1) (WD repeat-containing protein 98)	Homo sapiens (Human)	regulation of autophagy [GO:0010506]		late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658]	GO:0005765; GO:0005770; GO:0010506; GO:0031902; GO:0035658
GN012422	GN012422.1	Q08BD8	26.8	396	417	336	1.48e-14	77.8	MTRF2_DANRE	Mitochondrial fission regulator 2	Danio rerio (Zebrafish) (Brachydanio rerio)	aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266]		mitochondrion [GO:0005739]	GO:0000266; GO:0005739; GO:0009060
GN012425	GN012425.1	O89000	72.0	988	998	1025	0.0	1477	DPYD_RAT	Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)	Rattus norvegicus (Rat)	beta-alanine biosynthetic process [GO:0019483]; circadian rhythm [GO:0007623]; CMP catabolic process [GO:0006248]; dCMP catabolic process [GO:0006249]; dUMP catabolic process [GO:0046079]; purine nucleobase catabolic process [GO:0006145]; pyrimidine nucleobase catabolic process [GO:0006208]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; thymidine catabolic process [GO:0006214]; thymine catabolic process [GO:0006210]; TMP catabolic process [GO:0046045]; UMP catabolic process [GO:0046050]; uracil catabolic process [GO:0006212]; uracil metabolic process [GO:0019860]; xenobiotic catabolic process [GO:0042178]	dihydropyrimidine dehydrogenase (NADP+) activity [GO:0017113]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; iron-sulfur cluster binding [GO:0051536]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; uracil binding [GO:0002058]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0002058; GO:0005506; GO:0005737; GO:0005829; GO:0006145; GO:0006208; GO:0006210; GO:0006212; GO:0006214; GO:0006248; GO:0006249; GO:0007584; GO:0007623; GO:0009410; GO:0010181; GO:0017113; GO:0019483; GO:0019860; GO:0042178; GO:0042802; GO:0042803; GO:0046045; GO:0046050; GO:0046079; GO:0050660; GO:0050661; GO:0051384; GO:0051536; GO:0071949
GN012426	GN012426.1	Q92521	41.0	566	637	554	2.26e-141	426	PIGB_HUMAN	GPI alpha-1,2-mannosyltransferase 3 (EC 2.4.1.-) (GPI mannosyltransferase III) (GPI-MT-III) (Phosphatidylinositol-glycan biosynthesis class B protein) (PIG-B)	Homo sapiens (Human)	GPI anchor biosynthetic process [GO:0006506]	alpha-1,2-mannosyltransferase activity [GO:0000026]; dol-P-Man:Man(2)GlcN-acyl-PI alpha-1,2-mannosyltransferase activity [GO:0120564]; GPI mannosyltransferase activity [GO:0004376]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0000026; GO:0004376; GO:0005789; GO:0006506; GO:0016020; GO:0120564
GN012427	GN012427.1	Q8CFD5	52.0	404	405	397	1.15e-147	427	ERCC8_MOUSE	DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA homolog)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; positive regulation of DNA repair [GO:0045739]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of transcription-coupled nucleotide-excision repair [GO:0090262]; response to auditory stimulus [GO:0010996]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; transcription-coupled nucleotide-excision repair [GO:0006283]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	chromosome [GO:0005694]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; nuclear matrix [GO:0016363]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734]	GO:0000012; GO:0000109; GO:0000209; GO:0005634; GO:0005694; GO:0006283; GO:0006974; GO:0006979; GO:0009411; GO:0010165; GO:0010996; GO:0016363; GO:0016567; GO:0031464; GO:0032991; GO:0043161; GO:0043204; GO:0045739; GO:0051865; GO:0080008; GO:0090262; GO:0090734; GO:0097680; GO:1990756
GN012428	GN012428.1	Q9JJT0	64.6	254	257	373	1.50e-110	326	RCL1_MOUSE	RNA 3'-terminal phosphate cyclase-like protein	Mus musculus (Mouse)	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	RNA endonuclease activity [GO:0004521]	nucleolus [GO:0005730]; small-subunit processome [GO:0032040]	GO:0000447; GO:0000480; GO:0004521; GO:0005730; GO:0006364; GO:0032040; GO:0042274
GN012429	GN012429.1	Q3ZBD9	57.0	277	269	268	2.33e-98	291	MARE1_BOVIN	Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)	Bos taurus (Bovine)	attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; establishment of mitotic spindle orientation [GO:0000132]; negative regulation of microtubule polymerization [GO:0031115]; positive regulation of protein localization [GO:1903829]; protein localization to astral microtubule [GO:1902888]; protein localization to microtubule [GO:0035372]; regulation of microtubule polymerization or depolymerization [GO:0031110]; spindle assembly [GO:0051225]	microtubule plus-end binding [GO:0051010]	centrosome [GO:0005813]; cortical microtubule cytoskeleton [GO:0030981]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule plus-end [GO:0035371]; mitotic spindle pole [GO:0097431]; plasma membrane [GO:0005886]; spindle midzone [GO:0051233]	GO:0000132; GO:0005737; GO:0005794; GO:0005813; GO:0005874; GO:0005886; GO:0030981; GO:0031110; GO:0031115; GO:0035371; GO:0035372; GO:0051010; GO:0051225; GO:0051233; GO:0051315; GO:0097431; GO:1902888; GO:1903829
GN012433	GN012433.1	Q9UHY1	57.4	491	518	535	1.11e-178	516	NRBP_HUMAN	Nuclear receptor-binding protein	Homo sapiens (Human)	DNA damage response [GO:0006974]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation [GO:0050673]; in utero embryonic development [GO:0001701]; intracellular signal transduction [GO:0035556]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of monoatomic cation transmembrane transport [GO:1904062]	ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]	cell cortex [GO:0005938]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	GO:0001701; GO:0004674; GO:0005524; GO:0005654; GO:0005829; GO:0005938; GO:0006888; GO:0006974; GO:0012505; GO:0030027; GO:0030855; GO:0035556; GO:0042803; GO:0048471; GO:0050673; GO:0090263; GO:1904062
GN012435	GN012435.1	Q9UNH5	67.4	445	554	594	6.87e-219	622	CC14A_HUMAN	Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A)	Homo sapiens (Human)	cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of cytokinesis [GO:0032467]; regulation of exit from mitosis [GO:0007096]; sensory perception of sound [GO:0007605]	protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinociliary basal body [GO:1902636]; kinocilium [GO:0060091]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; stereocilium tip [GO:0032426]	GO:0000226; GO:0000922; GO:0004722; GO:0004725; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005813; GO:0007096; GO:0007605; GO:0032426; GO:0032467; GO:0060091; GO:0060271; GO:0072686; GO:1902636
GN012436	GN012436.1	Q7RTV5	44.4	189	231	226	2.00e-54	177	PXL2C_HUMAN	Peroxiredoxin-like 2C (AhpC/TSA antioxidant enzyme domain-containing protein 1) (Thioredoxin-like protein AAED1)	Homo sapiens (Human)	positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glycolytic process [GO:0045821]			GO:0045821; GO:0070374
GN012437	GN012437.1	P70032	44.9	196	219	598	2.85e-49	172	PLK1_XENLA	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Plx1) (Polo-like kinase 1) (PLK-1)	Xenopus laevis (African clawed frog)	centrosome cycle [GO:0007098]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule bundle formation [GO:0001578]; mitotic cell cycle [GO:0000278]; mitotic cleavage furrow formation [GO:1903673]; mitotic cytokinesis [GO:0000281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte maturation [GO:0001556]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein localization to chromatin [GO:0071168]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]	GO:0000086; GO:0000122; GO:0000278; GO:0000281; GO:0000776; GO:0000922; GO:0001556; GO:0001578; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0007052; GO:0007095; GO:0007098; GO:0008017; GO:0019901; GO:0030496; GO:0043066; GO:0045842; GO:0051233; GO:0071168; GO:0106310; GO:1903673; GO:2000042
GN012440	GN012440.1	Q92544	65.9	637	622	642	2.59e-299	830	TM9S4_HUMAN	Transmembrane 9 superfamily member 4 (Tumor cannibalism associated protein 1)	Homo sapiens (Human)	cell adhesion [GO:0007155]; Golgi to plasma membrane transport [GO:0006893]; phagocytosis [GO:0006909]; protein localization to membrane [GO:0072657]; regulation of intracellular pH [GO:0051453]; response to hypoxia [GO:0001666]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]	cargo receptor activity [GO:0038024]	early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0001666; GO:0005769; GO:0005794; GO:0006893; GO:0006909; GO:0007155; GO:0016020; GO:0038024; GO:0051453; GO:0070072; GO:0072657
GN012441	GN012441.1	P62205	43.3	603	668	598	3.18e-167	494	PLK1_XENTR	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Plx1) (Polo-like kinase 1) (PLK-1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mitotic cell cycle [GO:0000278]; mitotic cleavage furrow formation [GO:1903673]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic spindle organization [GO:0007052]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein localization to chromatin [GO:0071168]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle pole [GO:0000922]	GO:0000278; GO:0000776; GO:0000922; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0007052; GO:0007095; GO:0030496; GO:0071168; GO:0106310; GO:1903673; GO:2000042
GN012442	GN012442.1	Q15906	29.6	328	319	364	5.93e-20	92.4	VPS72_HUMAN	Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; transcription initiation-coupled chromatin remodeling [GO:0045815]	histone binding [GO:0042393]; histone chaperone activity [GO:0140713]	NuA4 histone acetyltransferase complex [GO:0035267]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000122; GO:0000786; GO:0005634; GO:0005654; GO:0006338; GO:0006355; GO:0016607; GO:0032991; GO:0035267; GO:0042393; GO:0042981; GO:0045815; GO:0045893; GO:0051726; GO:0140713; GO:1905168; GO:2000779
GN012445	GN012445.1	Q9VEN1	42.1	845	848	2210	1.89e-215	669	FLNA_DROME	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Filamin-1) (Filamin1)	Drosophila melanogaster (Fruit fly)	actin crosslink formation [GO:0051764]; behavioral response to ethanol [GO:0048149]; determination of adult lifespan [GO:0008340]; female germline ring canal formation [GO:0007301]; female germline ring canal formation, actin assembly [GO:0008302]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germline ring canal formation [GO:0030725]; intracellular protein localization [GO:0008104]; long-term memory [GO:0007616]; mitotic cell cycle [GO:0000278]; motor neuron axon guidance [GO:0008045]; negative regulation of lamellocyte differentiation [GO:0035204]; positive regulation of cytoskeleton organization [GO:0051495]; sarcomere organization [GO:0045214]; syncytial embryo cellularization [GO:0110069]	actin binding [GO:0003779]; actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; apical cortex [GO:0045179]; cytosol [GO:0005829]; female germline ring canal [GO:0035324]; female germline ring canal inner rim [GO:0035183]; female germline ring canal outer rim [GO:0035182]; plasma membrane [GO:0005886]; Z disc [GO:0030018]	GO:0000278; GO:0003779; GO:0005829; GO:0005886; GO:0007301; GO:0007616; GO:0008045; GO:0008104; GO:0008302; GO:0008340; GO:0015629; GO:0030018; GO:0030708; GO:0030725; GO:0035182; GO:0035183; GO:0035204; GO:0035324; GO:0045179; GO:0045214; GO:0048149; GO:0051015; GO:0051495; GO:0051764; GO:0110069
GN012447	GN012447.1	O70496	52.7	188	183	803	1.81e-48	171	CLCN7_MOUSE	H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7)	Mus musculus (Mouse)	chloride transmembrane transport [GO:1902476]; response to pH [GO:0009268]; transepithelial chloride transport [GO:0030321]	chloride channel activity [GO:0005254]; chloride:proton antiporter activity [GO:0062158]	chloride channel complex [GO:0034707]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]	GO:0005254; GO:0005765; GO:0005770; GO:0009268; GO:0030321; GO:0034707; GO:0062158; GO:1902476
GN012448	GN012448.1	O70496	59.4	547	585	803	6.58e-215	620	CLCN7_MOUSE	H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7)	Mus musculus (Mouse)	chloride transmembrane transport [GO:1902476]; response to pH [GO:0009268]; transepithelial chloride transport [GO:0030321]	chloride channel activity [GO:0005254]; chloride:proton antiporter activity [GO:0062158]	chloride channel complex [GO:0034707]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]	GO:0005254; GO:0005765; GO:0005770; GO:0009268; GO:0030321; GO:0034707; GO:0062158; GO:1902476
GN012449	GN012449.1	Q9CZT4	44.1	716	692	710	5.70e-184	542	RPC5_MOUSE	DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit 5) (RNA polymerase III subunit C5) (Sex-lethal interactor homolog) (Sxl interactor)	Mus musculus (Mouse)	termination of RNA polymerase III transcription [GO:0006386]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]	GO:0005634; GO:0005654; GO:0005666; GO:0006383; GO:0006384; GO:0006386
GN012450	GN012450.1	O75382	25.3	300	389	744	1.49e-12	72.8	TRIM3_HUMAN	Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)	Homo sapiens (Human)	nervous system development [GO:0007399]; neural precursor cell proliferation [GO:0061351]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]	GO:0000209; GO:0005737; GO:0005769; GO:0005794; GO:0007399; GO:0008270; GO:0030425; GO:0034141; GO:0042802; GO:0043161; GO:0061351; GO:0061630; GO:0070534
GN012451	GN012451.1	Q8NE00	46.8	252	252	496	4.37e-61	202	S38AC_HUMAN	Putative sodium-coupled neutral amino acid transporter 12 (Solute carrier family 38 member 12)	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN012453	GN012453.1	Q95108	60.0	70	156	166	4.64e-27	102	THIOM_BOVIN	Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)	Bos taurus (Bovine)		protein-disulfide reductase activity [GO:0015035]	mitochondrion [GO:0005739]	GO:0005739; GO:0015035
GN012454	GN012454.1	Q5ZKV8	59.2	632	623	706	1.10e-238	679	KIF2A_CHICK	Kinesin-like protein KIF2A	Gallus gallus (Chicken)	microtubule-based movement [GO:0007018]; mitotic spindle organization [GO:0007052]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinesin complex [GO:0005871]; spindle [GO:0005819]; spindle pole [GO:0000922]	GO:0000922; GO:0003777; GO:0005524; GO:0005737; GO:0005813; GO:0005819; GO:0005871; GO:0007018; GO:0007052; GO:0008017
GN012455	GN012455.1	O16327	41.2	165	427	212	7.95e-32	123	IRG1_CAEEL	Protein irg-1 (Infection response protein 1)	Caenorhabditis elegans	antibacterial innate immune response [GO:0140367]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]			GO:0045087; GO:0050829; GO:0140367
GN012457	GN012457.1	Q92035	30.3	409	490	606	2.80e-55	197	ACES_BUNFA	Acetylcholinesterase (BfAChE) (EC 3.1.1.7)	Bungarus fasciatus (Banded krait) (Pseudoboa fasciata)	acetylcholine catabolic process in synaptic cleft [GO:0001507]; choline metabolic process [GO:0019695]	acetylcholinesterase activity [GO:0003990]	plasma membrane [GO:0005886]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001507; GO:0003990; GO:0005886; GO:0019695; GO:0043083; GO:0045202
GN012458	GN012458.1	P41827	75.9	638	634	640	0.0	962	HSP74_ANOAL	Heat shock protein 70 B2	Anopheles albimanus (New world malaria mosquito)	response to stress [GO:0006950]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]		GO:0005524; GO:0006950; GO:0016887
GN012459	GN012459.1	P41827	75.7	638	634	640	0.0	960	HSP74_ANOAL	Heat shock protein 70 B2	Anopheles albimanus (New world malaria mosquito)	response to stress [GO:0006950]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]		GO:0005524; GO:0006950; GO:0016887
GN012460	GN012460.1	P41827	75.9	638	634	640	0.0	962	HSP74_ANOAL	Heat shock protein 70 B2	Anopheles albimanus (New world malaria mosquito)	response to stress [GO:0006950]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]		GO:0005524; GO:0006950; GO:0016887
GN012461	GN012461.1	Q9Y547	47.8	136	139	144	2.60e-38	129	IFT25_HUMAN	Intraflagellar transport protein 25 homolog (Heat shock protein beta-11) (Hspb11) (Heat shock protein family B member 11) (Placental protein 25) (PP25)	Homo sapiens (Human)	cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; kidney development [GO:0001822]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283]		centrosome [GO:0005813]; ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]; intraciliary transport particle B [GO:0030992]	GO:0001822; GO:0005813; GO:0005929; GO:0007224; GO:0007283; GO:0030991; GO:0030992; GO:0035720; GO:0060271; GO:0097542
GN012463	GN012463.1	Q5R580	62.5	136	252	320	7.40e-54	179	ZRAB2_PONAB	Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	RNA processing [GO:0006396]	lipopolysaccharide binding [GO:0001530]; RNA binding [GO:0003723]	nucleus [GO:0005634]	GO:0001530; GO:0003723; GO:0005634; GO:0006396
GN012468	GN012468.1	O08796	51.0	647	686	724	5.28e-195	571	EF2K_MOUSE	Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase)	Mus musculus (Mouse)	cellular response to anoxia [GO:0071454]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to insulin stimulus [GO:0032869]; negative regulation of apoptotic process [GO:0043066]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of endocytosis [GO:0045807]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of protein autophosphorylation [GO:0031952]; regulation of translation at postsynapse [GO:0140245]; response to ischemia [GO:0002931]; response to prolactin [GO:1990637]; translational elongation [GO:0006414]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; elongation factor-2 kinase activity [GO:0004686]; translation factor activity, RNA binding [GO:0008135]	dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]	GO:0002931; GO:0004686; GO:0005509; GO:0005516; GO:0005524; GO:0006414; GO:0008135; GO:0014069; GO:0031952; GO:0032869; GO:0043066; GO:0043197; GO:0045807; GO:0046777; GO:0051965; GO:0061003; GO:0071277; GO:0071320; GO:0071454; GO:0098978; GO:0140245; GO:1990416; GO:1990637
GN012469	GN012469.1	Q92747	45.7	328	326	370	8.45e-92	281	ARC1A_HUMAN	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cortical actin cytoskeleton organization [GO:0030866]	actin binding [GO:0003779]; actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; muscle cell projection membrane [GO:0036195]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0003779; GO:0005634; GO:0005829; GO:0005885; GO:0015629; GO:0030036; GO:0030866; GO:0034314; GO:0035861; GO:0036195; GO:0051015; GO:0070062; GO:0098978
GN012470	GN012470.1	Q2L6K8	52.1	190	237	217	1.41e-64	202	CNPY4_DANRE	Protein canopy 4	Danio rerio (Zebrafish) (Brachydanio rerio)		signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0005102; GO:0005576
GN012471	GN012471.1	Q6ZPJ0	34.6	676	901	1128	1.13e-98	337	TEX2_MOUSE	Testis-expressed protein 2	Mus musculus (Mouse)		lipid binding [GO:0008289]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]	GO:0005783; GO:0005789; GO:0008289; GO:0031965
GN012473	GN012473.1	O75460	46.5	891	816	977	2.15e-236	691	ERN1_HUMAN	Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]	Homo sapiens (Human)	cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to unfolded protein [GO:0034620]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endoplasmic reticulum unfolded protein response [GO:0030968]; endothelial cell proliferation [GO:0001935]; insulin metabolic process [GO:1901142]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; mRNA catabolic process [GO:0006402]; mRNA splicing, via endonucleolytic cleavage and ligation [GO:0070054]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of JNK cascade [GO:0046330]; positive regulation of RNA splicing [GO:0033120]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein phosphorylation [GO:0006468]; regulation of macroautophagy [GO:0016241]; response to endoplasmic reticulum stress [GO:0034976]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; RNA endonuclease activity [GO:0004521]	AIP1-IRE1 complex [GO:1990597]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Ire1 complex [GO:1990332]; IRE1-RACK1-PP2A complex [GO:1990630]; IRE1-TRAF2-ASK1 complex [GO:1990604]; mitochondrion [GO:0005739]; nuclear inner membrane [GO:0005637]	GO:0000287; GO:0001935; GO:0004521; GO:0004674; GO:0005161; GO:0005524; GO:0005637; GO:0005737; GO:0005739; GO:0005783; GO:0005789; GO:0006402; GO:0006468; GO:0016241; GO:0019899; GO:0030544; GO:0030968; GO:0033120; GO:0034620; GO:0034976; GO:0035924; GO:0036498; GO:0042802; GO:0042803; GO:0043531; GO:0046330; GO:0051879; GO:0070054; GO:0070059; GO:0070301; GO:0071333; GO:0106310; GO:1900103; GO:1901142; GO:1904707; GO:1990332; GO:1990597; GO:1990604; GO:1990630
GN012475	GN012475.1	Q5ZJB4	40.3	764	752	759	6.11e-181	538	IKKA_CHICK	Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)	Gallus gallus (Chicken)	cellular response to tumor necrosis factor [GO:0071356]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of transcription by RNA polymerase II [GO:0045944]; toll-like receptor signaling pathway [GO:0002224]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	ATP binding [GO:0005524]; IkappaB kinase activity [GO:0008384]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; nucleus [GO:0005634]	GO:0002224; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0008384; GO:0008385; GO:0033209; GO:0042803; GO:0043123; GO:0045944; GO:0046982; GO:0071356
GN012476	GN012476.1	Q5ZJB4	43.4	739	728	759	8.22e-198	581	IKKA_CHICK	Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)	Gallus gallus (Chicken)	cellular response to tumor necrosis factor [GO:0071356]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of transcription by RNA polymerase II [GO:0045944]; toll-like receptor signaling pathway [GO:0002224]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	ATP binding [GO:0005524]; IkappaB kinase activity [GO:0008384]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; IkappaB kinase complex [GO:0008385]; nucleus [GO:0005634]	GO:0002224; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0008384; GO:0008385; GO:0033209; GO:0042803; GO:0043123; GO:0045944; GO:0046982; GO:0071356
GN012477	GN012477.1	Q7K237	54.0	263	382	388	1.08e-95	293	C1GLT_DROME	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1)	Drosophila melanogaster (Fruit fly)	central nervous system morphogenesis [GO:0021551]; glycolipid biosynthetic process [GO:0009247]; muscle cell development [GO:0055001]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; neuromuscular junction development [GO:0007528]; protein O-linked glycosylation via N-acetyl-galactosamine [GO:0016266]; regulation of filopodium assembly [GO:0051489]	beta-1,3-galactosyltransferase activity [GO:0048531]; manganese ion binding [GO:0030145]; N-acetylgalactosaminide beta-1,3-galactosyltransferase activity [GO:0016263]; protein homodimerization activity [GO:0042803]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0007528; GO:0009247; GO:0016020; GO:0016263; GO:0016266; GO:0021551; GO:0030145; GO:0042803; GO:0048531; GO:0051489; GO:0055001; GO:1902037
GN012479	GN012479.1	Q9VVI9	57.6	224	221	226	4.85e-78	236	CHMP5_DROME	Charged multivesicular body protein 5 (Vacuolar protein-sorting-associated protein 60)	Drosophila melanogaster (Fruit fly)	endosome transport via multivesicular body sorting pathway [GO:0032509]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; membrane fission [GO:0090148]; multivesicular body assembly [GO:0036258]; nuclear membrane reassembly [GO:0031468]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; symbiont entry into host cell [GO:0046718]		ESCRT III complex [GO:0000815]; nuclear envelope [GO:0005635]	GO:0000815; GO:0005635; GO:0031468; GO:0032509; GO:0032511; GO:0036258; GO:0043328; GO:0046718; GO:0090148
GN012480	GN012480.1	C3Z724	69.9	209	218	213	6.33e-101	294	UBE2S_BRAFL	Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (Ubiquitin carrier protein S) (Ubiquitin-protein ligase S)	Branchiostoma floridae (Florida lancelet) (Amphioxus)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; exit from mitosis [GO:0010458]; free ubiquitin chain polymerization [GO:0010994]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein K11-linked ubiquitination [GO:0070979]; protein polyubiquitination [GO:0000209]	ubiquitin conjugating enzyme activity [GO:0061631]	anaphase-promoting complex [GO:0005680]	GO:0000209; GO:0005680; GO:0010458; GO:0010994; GO:0031145; GO:0061631; GO:0070979; GO:1904668
GN012481	GN012481.1	P52505	55.6	108	151	156	1.59e-32	115	ACPM_BOVIN	Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit)	Bos taurus (Bovine)	[2Fe-2S] cluster assembly [GO:0044571]; fatty acid biosynthetic process [GO:0006633]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]	acyl binding [GO:0000035]; fatty acid binding [GO:0005504]; mitochondrial large ribosomal subunit binding [GO:0140978]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; oxidoreductase activity [GO:0016491]	mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271]	GO:0000035; GO:0005504; GO:0005739; GO:0005759; GO:0006120; GO:0006633; GO:0008137; GO:0016491; GO:0031966; GO:0044571; GO:0045271; GO:0140978
GN012482	GN012482.1	Q96Q04	37.1	385	1002	1460	1.49e-58	223	LMTK3_HUMAN	Serine/threonine-protein kinase LMTK3 (EC 2.7.11.1) (Lemur tyrosine kinase 3)	Homo sapiens (Human)		ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	axon [GO:0030424]; dendrite [GO:0030425]; Golgi membrane [GO:0000139]	GO:0000139; GO:0004672; GO:0004674; GO:0005524; GO:0030424; GO:0030425; GO:0106310
GN012483	GN012483.1	B1AQJ2	50.0	404	1092	1098	1.47e-129	425	UBP36_MOUSE	Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36)	Mus musculus (Mouse)	chromatin organization [GO:0006325]; negative regulation of macroautophagy [GO:0016242]; nucleolus organization [GO:0007000]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647]; regulation of rRNA processing [GO:2000232]	cysteine-type deubiquitinase activity [GO:0004843]; histone H2B deubiquitinase activity [GO:0140936]; K48-linked deubiquitinase activity [GO:1990380]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0004843; GO:0005654; GO:0005730; GO:0005737; GO:0006325; GO:0007000; GO:0016242; GO:0016579; GO:0016607; GO:0031647; GO:0042981; GO:0050821; GO:0140936; GO:1990380; GO:2000232
GN012486	GN012486.1	Q7TN88	27.1	1476	2758	2461	1.17e-130	465	PK1L2_MOUSE	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Mus musculus (Mouse)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]	membrane [GO:0016020]	GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN012487	GN012487.1	Q7Z442	26.3	971	861	2459	6.41e-86	304	PK1L2_HUMAN	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Homo sapiens (Human)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]	membrane [GO:0016020]	GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN012488	GN012488.1	Q7TN88	36.0	311	1971	2461	5.00e-44	181	PK1L2_MOUSE	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Mus musculus (Mouse)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]	membrane [GO:0016020]	GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN012490	GN012490.1	Q9Y2V2	55.1	127	143	147	2.44e-45	147	CHSP1_HUMAN	Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24)	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]; regulation of mRNA stability [GO:0043488]	mRNA 3'-UTR binding [GO:0003730]; phosphatase binding [GO:0019902]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; P granule [GO:0043186]; P-body [GO:0000932]	GO:0000177; GO:0000932; GO:0003730; GO:0005737; GO:0005829; GO:0019902; GO:0035556; GO:0043186; GO:0043488
GN012492	GN012492.1	Q28DV3	71.7	427	433	428	5.95e-248	684	HDAC3_XENTR	Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	circadian regulation of gene expression [GO:0032922]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of circadian rhythm [GO:0042752]	chromatin binding [GO:0003682]; histone deacetylase activity, hydrolytic mechanism [GO:0141221]; histone decrotonylase activity [GO:0160009]; histone isonicotinyllysine deisonicotinylase activity [GO:0140229]; protein de-2-hydroxyisobutyrylase activity [GO:0160010]; protein decrotonylase activity [GO:0160008]; protein lysine deacetylase activity [GO:0033558]; protein lysine delactylase activity [GO:0160216]; transcription corepressor activity [GO:0003714]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; transcription repressor complex [GO:0017053]	GO:0000122; GO:0003682; GO:0003714; GO:0005634; GO:0005694; GO:0005737; GO:0005829; GO:0017053; GO:0032922; GO:0033558; GO:0042752; GO:0140229; GO:0141221; GO:0160008; GO:0160009; GO:0160010; GO:0160216
GN012493	GN012493.1	Q7JR71	44.3	149	332	181	1.87e-29	114	SODE_DROME	Extracellular superoxide dismutase [Cu-Zn] (EC 1.15.1.1)	Drosophila melanogaster (Fruit fly)	nitric oxide metabolic process [GO:0046209]; removal of superoxide radicals [GO:0019430]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650]	copper ion binding [GO:0005507]; superoxide dismutase activity [GO:0004784]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0004784; GO:0005507; GO:0005576; GO:0005886; GO:0006979; GO:0009650; GO:0019430; GO:0046209
GN012495	GN012495.1	Q91W43	71.2	299	299	1025	1.79e-149	447	GCSP_MOUSE	Glycine dehydrogenase (decarboxylating), mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring))	Mus musculus (Mouse)	cellular response to leukemia inhibitory factor [GO:1990830]; glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]; protein-containing complex assembly [GO:0065003]; response to lipoic acid [GO:1903442]; response to methylamine [GO:0036255]	enzyme binding [GO:0019899]; glycine binding [GO:0016594]; glycine dehydrogenase (decarboxylating) activity [GO:0004375]; lyase activity [GO:0016829]; protein homodimerization activity [GO:0042803]; pyridoxal binding [GO:0070280]; pyridoxal phosphate binding [GO:0030170]	glycine cleavage complex [GO:0005960]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0004375; GO:0005654; GO:0005739; GO:0005886; GO:0005960; GO:0006546; GO:0016594; GO:0016829; GO:0019464; GO:0019899; GO:0030170; GO:0036255; GO:0042803; GO:0065003; GO:0070280; GO:1903442; GO:1990830
GN012496	GN012496.1	P15505	76.5	481	493	1004	4.42e-274	775	GCSP_CHICK	Glycine dehydrogenase (decarboxylating), mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring))	Gallus gallus (Chicken)	glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]; response to lipoic acid [GO:1903442]; response to methylamine [GO:0036255]	glycine dehydrogenase (decarboxylating) activity [GO:0004375]; glycine dehydrogenase (NAD+) activity [GO:0047960]; lyase activity [GO:0016829]; protein homodimerization activity [GO:0042803]; pyridoxal binding [GO:0070280]	mitochondrion [GO:0005739]	GO:0004375; GO:0005739; GO:0006546; GO:0016829; GO:0019464; GO:0036255; GO:0042803; GO:0047960; GO:0070280; GO:1903442
GN012498	GN012498.1	Q9MZD1	35.6	376	402	495	9.53e-64	215	S17A5_SHEEP	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein SP55) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)	Ovis aries (Sheep)	monoatomic anion transport [GO:0006820]	D-glucuronate transmembrane transporter activity [GO:0042880]; sialic acid:proton symporter activity [GO:0015538]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; lysosomal membrane [GO:0005765]; synaptic vesicle membrane [GO:0030672]	GO:0005765; GO:0006820; GO:0015538; GO:0016323; GO:0016324; GO:0030672; GO:0042880
GN012499	GN012499.1	Q8BJW7	36.3	331	625	570	1.54e-47	179	EME1_MOUSE	Structure-specific endonuclease subunit EME1	Mus musculus (Mouse)	double-strand break repair [GO:0006302]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]; resolution of mitotic recombination intermediates [GO:0071140]; response to intra-S DNA damage checkpoint signaling [GO:0072429]	crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677]	chromatin [GO:0000785]; endodeoxyribonuclease complex [GO:1905347]; heterochromatin [GO:0000792]; Holliday junction resolvase complex [GO:0048476]; nuclear chromosome [GO:0000228]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]	GO:0000228; GO:0000712; GO:0000785; GO:0000792; GO:0003677; GO:0005730; GO:0006302; GO:0008821; GO:0031297; GO:0031573; GO:0043596; GO:0048476; GO:0071140; GO:0072429; GO:1905347
GN012500	GN012500.1	Q32PC3	39.5	124	145	148	3.98e-18	78.6	RM27_BOVIN	Large ribosomal subunit protein bL27m (39S ribosomal protein L27, mitochondrial) (L27mt) (MRP-L27)	Bos taurus (Bovine)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005762; GO:0006412
GN012501	GN012501.1	Q5ZMU0	42.4	144	144	233	1.05e-30	113	RT07_CHICK	Small ribosomal subunit protein uS7m (28S ribosomal protein S7, mitochondrial) (MRP-S7) (S7mt)	Gallus gallus (Chicken)	mitochondrial translation [GO:0032543]; translation [GO:0006412]	rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; ribosome [GO:0005840]	GO:0003735; GO:0005739; GO:0005743; GO:0005763; GO:0005840; GO:0006412; GO:0019843; GO:0032543
GN012503	GN012503.1	Q3LHL9	37.0	535	2289	1658	8.60e-74	278	WGE_DROME	Protein winged eye	Drosophila melanogaster (Fruit fly)	imaginal disc morphogenesis [GO:0007560]; positive regulation of heterochromatin formation [GO:0031453]; regulation of gene expression [GO:0010468]; transposable element silencing by heterochromatin formation [GO:0141005]	chromatin binding [GO:0003682]	chromatin [GO:0000785]; histone locus body [GO:0035363]	GO:0000785; GO:0003682; GO:0007560; GO:0010468; GO:0031453; GO:0035363; GO:0141005
GN012504	GN012504.1	Q7ZXX2	53.1	732	938	997	1.49e-229	678	KIF19_XENLA	Kinesin-like protein KIF19	Xenopus laevis (African clawed frog)	axonemal microtubule depolymerization [GO:0060404]; microtubule-based movement [GO:0007018]; plus-end specific microtubule depolymerization [GO:0070462]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]	axoneme [GO:0005930]; cilium [GO:0005929]	GO:0005524; GO:0005929; GO:0005930; GO:0007018; GO:0008017; GO:0008574; GO:0060404; GO:0070462
GN012506	GN012506.1	P97868	51.3	337	1539	1790	4.55e-94	340	RBBP6_MOUSE	E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; embryonic organ development [GO:0048568]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; protein ubiquitination [GO:0016567]; regulation of DNA replication [GO:0006275]; somite development [GO:0061053]; ubiquitin-dependent protein catabolic process [GO:0006511]	nucleic acid binding [GO:0003676]; protein kinase binding [GO:0019901]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; protein-containing complex [GO:0032991]	GO:0001701; GO:0003676; GO:0004842; GO:0005694; GO:0005730; GO:0005813; GO:0006275; GO:0006397; GO:0006511; GO:0006974; GO:0008270; GO:0016567; GO:0016607; GO:0019901; GO:0032991; GO:0035264; GO:0048568; GO:0061053; GO:0061630
GN012508	GN012508.1	Q9VKJ9	38.2	843	1065	816	2.09e-149	469	C2D1_DROME	Coiled-coil and C2 domain-containing protein 1-like (Lethal (2) giant discs 1 protein)	Drosophila melanogaster (Fruit fly)	compound eye development [GO:0048749]; endosomal transport [GO:0016197]; endosome transport via multivesicular body sorting pathway [GO:0032509]; female germ-line stem cell asymmetric division [GO:0048132]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; intracellular protein transport [GO:0006886]; mitotic cytokinesis [GO:0000281]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of intralumenal vesicle formation [GO:1905367]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory organ development [GO:0007423]; sensory organ precursor cell division [GO:0045035]; wing disc morphogenesis [GO:0007472]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; phosphatidylinositol phosphate binding [GO:1901981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	apicolateral plasma membrane [GO:0016327]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of apical plasma membrane [GO:0098592]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; nucleus [GO:0005634]	GO:0000281; GO:0000978; GO:0000981; GO:0001227; GO:0005634; GO:0005737; GO:0005768; GO:0005829; GO:0005938; GO:0006357; GO:0006886; GO:0007423; GO:0007472; GO:0008586; GO:0010008; GO:0016197; GO:0016327; GO:0032509; GO:0045035; GO:0045746; GO:0048132; GO:0048749; GO:0098592; GO:1901981; GO:1905367
GN012510	GN012510.1	Q9H3U5	33.2	455	481	465	7.06e-65	219	MFSD1_HUMAN	Lysosomal dipeptide transporter MFSD1 (Major facilitator superfamily domain-containing protein 1) (Smooth muscle cell-associated protein 4) (SMAP-4)	Homo sapiens (Human)	dipeptide transmembrane transport from lysosomal lumen to cytosol [GO:0141204]; protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821]	dipeptide uniporter activity [GO:0160178]; protein homodimerization activity [GO:0042803]	lysosomal membrane [GO:0005765]; lysosome [GO:0005764]	GO:0005764; GO:0005765; GO:0042803; GO:0050821; GO:0061462; GO:0141204; GO:0160178
GN012511	GN012511.1	A2VDD2	36.5	126	253	176	3.90e-18	82.4	DYL5B_XENLA	Dynein light chain Tctex-type 5-B (Tctex1 domain-containing protein 1-B)	Xenopus laevis (African clawed frog)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505
GN012514	GN012514.1	Q19673	28.0	239	468	693	5.27e-23	105	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN012515	GN012515.1	A0A6I8TI61	34.8	543	847	954	8.99e-85	294	IR25A_AEDAE	Ionotropic receptor coreceptor Ir25a (Ionotropic receptor 25a)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	coreceptor activity [GO:0015026]; ligand-gated monoatomic ion channel activity [GO:0015276]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0007608; GO:0015026; GO:0015276; GO:0050911
GN012516	GN012516.1	Q15750	47.2	489	531	504	2.31e-122	371	TAB1_HUMAN	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)	Homo sapiens (Human)	canonical NF-kappaB signal transduction [GO:0007249]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; regulation of MAPK cascade [GO:0043408]	mitogen-activated protein kinase p38 binding [GO:0048273]; molecular adaptor activity [GO:0060090]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; serine/threonine protein kinase complex [GO:1902554]	GO:0004722; GO:0005737; GO:0005783; GO:0005789; GO:0005829; GO:0007249; GO:0010008; GO:0038061; GO:0043408; GO:0043539; GO:0044877; GO:0048273; GO:0060090; GO:0141111; GO:1902554
GN012517	GN012517.1	Q8IWX8	77.0	282	568	916	1.88e-62	224	CHERP_HUMAN	Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6)	Homo sapiens (Human)	intracellular calcium ion homeostasis [GO:0006874]; negative regulation of cell population proliferation [GO:0008285]; nervous system development [GO:0007399]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; release of sequestered calcium ion into cytosol [GO:0051209]; RNA processing [GO:0006396]	RNA binding [GO:0003723]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum membrane [GO:0033017]	GO:0003723; GO:0005654; GO:0005737; GO:0005783; GO:0006396; GO:0006874; GO:0007399; GO:0008285; GO:0016020; GO:0033017; GO:0044325; GO:0048471; GO:0051209; GO:0070886
GN012520	GN012520.1	Q8N461	51.5	229	458	479	2.05e-78	254	FXL16_HUMAN	F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16)	Homo sapiens (Human)	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]		cytosol [GO:0005829]	GO:0005829; GO:0031146
GN012521	GN012521.1	P17152	46.0	163	185	192	1.29e-40	139	TMM11_HUMAN	Transmembrane protein 11, mitochondrial (Protein PM1) (Protein PMI)	Homo sapiens (Human)	inner mitochondrial membrane organization [GO:0007007]; mitochondrion organization [GO:0007005]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0005739; GO:0005743; GO:0005886; GO:0007005; GO:0007007
GN012522	GN012522.1	Q9Y140	46.7	214	246	326	9.03e-64	204	DHRS7_DROME	Dehydrogenase/reductase SDR family protein 7-like (EC 1.1.-.-)	Drosophila melanogaster (Fruit fly)		acylglycerone-phosphate reductase (NADP+) activity [GO:0000140]	membrane [GO:0016020]; peroxisomal membrane [GO:0005778]	GO:0000140; GO:0005778; GO:0016020
GN012523	GN012523.1	P0C8Z3	66.3	436	588	514	8.42e-199	569	UBP22_BOVIN	Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22)	Bos taurus (Bovine)	protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; SAGA complex [GO:0000124]	GO:0000124; GO:0004843; GO:0005634; GO:0005737; GO:0008270; GO:0016579
GN012524	GN012524.1	Q8IV35	28.0	921	1250	1049	1.71e-97	339	CF337_HUMAN	Cilia- and flagella-associated protein 337 (WD repeat-containing protein 49)	Homo sapiens (Human)		calcium ion binding [GO:0005509]	cilium [GO:0005929]	GO:0005509; GO:0005929
GN012525	GN012525.1	Q3V2A7	39.2	378	1096	592	7.18e-64	231	QRIC2_MOUSE	Glutamine-rich protein 2	Mus musculus (Mouse)	cell projection assembly [GO:0030031]; flagellated sperm motility [GO:0030317]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]		cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005634; GO:0005737; GO:0030031; GO:0030317; GO:0031965; GO:0036126; GO:2000059
GN012526	GN012526.1	V5NAL9	35.6	872	861	899	7.53e-169	516	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN012527	GN012527.1	V5NAL9	32.9	346	368	899	3.40e-48	177	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN012528	GN012528.1	V5NAL9	53.7	162	161	899	8.52e-57	193	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN012543	GN012543.1	P41827	74.1	617	627	640	0.0	912	HSP74_ANOAL	Heat shock protein 70 B2	Anopheles albimanus (New world malaria mosquito)	response to stress [GO:0006950]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]		GO:0005524; GO:0006950; GO:0016887
GN012545	GN012545.1	P41827	74.1	617	627	640	0.0	912	HSP74_ANOAL	Heat shock protein 70 B2	Anopheles albimanus (New world malaria mosquito)	response to stress [GO:0006950]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]		GO:0005524; GO:0006950; GO:0016887
GN012546	GN012546.1	Q9NQM4	41.7	115	181	214	1.58e-18	82.4	DAAF6_HUMAN	Dynein axonemal assembly factor 6 (PIH1 domain-containing protein 3) (Sarcoma antigen NY-SAR-97)	Homo sapiens (Human)	axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158]	dynein intermediate chain binding [GO:0045505]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802]	GO:0003341; GO:0005737; GO:0005794; GO:0005802; GO:0030317; GO:0036158; GO:0036159; GO:0045505; GO:0051087; GO:0070286
GN012548	GN012548.1	O95393	41.7	391	403	424	1.43e-84	267	BMP10_HUMAN	Bone morphogenetic protein 10 (BMP-10)	Homo sapiens (Human)	activin receptor signaling pathway [GO:0032924]; adult heart development [GO:0007512]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; BMP signaling pathway [GO:0030509]; cardiac muscle cell proliferation [GO:0060038]; heart trabecula formation [GO:0060347]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell migration [GO:0010596]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of SMAD protein signal transduction [GO:0060391]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle hypertrophy in response to stress [GO:1903242]; sarcomere organization [GO:0045214]; ventricular cardiac muscle cell development [GO:0055015]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; receptor serine/threonine kinase binding [GO:0033612]; telethonin binding [GO:0031433]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Z disc [GO:0030018]	GO:0005125; GO:0005179; GO:0005576; GO:0005737; GO:0007512; GO:0008083; GO:0009986; GO:0010596; GO:0010613; GO:0010614; GO:0030018; GO:0030308; GO:0030336; GO:0030509; GO:0031433; GO:0032924; GO:0033612; GO:0045214; GO:0045893; GO:0055009; GO:0055010; GO:0055015; GO:0055117; GO:0060038; GO:0060045; GO:0060298; GO:0060347; GO:0060391; GO:0061036; GO:1903242; GO:2000138
GN012550	GN012550.1	Q8K0V2	54.2	216	291	304	6.30e-77	239	DCNL3_MOUSE	DCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3) (SCCRO3)	Mus musculus (Mouse)	negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of protein neddylation [GO:2000435]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]; regulation of cell cycle process [GO:0010564]; regulation of protein neddylation [GO:2000434]; response to gamma radiation [GO:0010332]; response to UV-C [GO:0010225]	cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0010225; GO:0010332; GO:0010564; GO:0030308; GO:0031624; GO:0032182; GO:0043065; GO:0045116; GO:0048471; GO:0097602; GO:2000134; GO:2000434; GO:2000435; GO:2000436
GN012551	GN012551.1	P42694	48.9	1000	1678	1942	5.59e-308	937	HELZ_HUMAN	ATP-dependent RNA helicase with zinc finger domain (EC 3.6.4.13) (Down-regulated in human cancers protein)	Homo sapiens (Human)	negative regulation of translation [GO:0017148]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; CCR4-NOT complex binding [GO:1905762]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; P granule [GO:0043186]	GO:0003723; GO:0003724; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0008284; GO:0016020; GO:0016887; GO:0017148; GO:0043186; GO:0046872; GO:1900153; GO:1905762
GN012553	GN012553.1	P22770	27.7	289	473	502	2.39e-22	103	ACHA7_CHICK	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005737; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030424; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043204; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN012554	GN012554.1	Q9U637	65.2	224	291	331	4.91e-80	248	PITX_BRABE	Pituitary homeobox x (Bicoid type transcription factor Pitx) (BbPtx) (Homeobox protein Ptx) (Paired-like homeodomain transcription factor x)	Branchiostoma belcheri (Amphioxus)	anatomical structure morphogenesis [GO:0009653]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0009653
GN012558	GN012558.1	O93384	70.4	297	345	348	8.92e-161	456	RSAD2_ONCMY	S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (SAND) (Radical S-adenosyl methionine domain-containing protein 2) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) (Viperin)	Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)	defense response to virus [GO:0051607]; positive regulation of immune response [GO:0050778]	4 iron, 4 sulfur cluster binding [GO:0051539]; catalytic activity [GO:0003824]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; mitochondrion [GO:0005739]	GO:0003824; GO:0005739; GO:0005789; GO:0005811; GO:0050778; GO:0051539; GO:0051607
GN012559	GN012559.1	Q92947	78.0	391	464	438	5.24e-229	637	GCDH_HUMAN	Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6)	Homo sapiens (Human)	fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty-acyl-CoA biosynthetic process [GO:0046949]; L-lysine catabolic process [GO:0019477]; L-tryptophan metabolic process [GO:0006568]	fatty-acyl-CoA binding [GO:0000062]; flavin adenine dinucleotide binding [GO:0050660]; glutaryl-CoA dehydrogenase activity [GO:0004361]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0000062; GO:0004361; GO:0005634; GO:0005739; GO:0005759; GO:0006568; GO:0019477; GO:0033539; GO:0046949; GO:0050660
GN012560	GN012560.1	Q99N01	34.0	103	107	723	1.40e-14	71.2	SO4A1_RAT	Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12)	Rattus norvegicus (Rat)	sodium-independent organic anion transport [GO:0043252]; thyroid hormone metabolic process [GO:0042403]	prostaglandin transmembrane transporter activity [GO:0015132]; thyroid hormone transmembrane transporter activity [GO:0015349]; transmembrane transporter activity [GO:0022857]	basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; plasma membrane [GO:0005886]	GO:0005886; GO:0015132; GO:0015349; GO:0016323; GO:0022857; GO:0030054; GO:0042403; GO:0043252
GN012561	GN012561.1	O43301	23.5	469	830	675	2.75e-16	87.0	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN012566	GN012566.1	Q8IVD9	34.5	322	331	361	2.96e-50	174	NUDC3_HUMAN	NudC domain-containing protein 3	Homo sapiens (Human)	cilium assembly [GO:0060271]; protein localization to pericentriolar material [GO:1905793]		cytoplasmic dynein complex [GO:0005868]	GO:0005868; GO:0060271; GO:1905793
GN012567	GN012567.1	O18783	49.3	75	79	806	3.05e-19	83.2	PLMN_NOTEU	Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin; Plasmin heavy chain A; Plasmin light chain B; Angiostatin]	Notamacropus eugenii (Tammar wallaby) (Macropus eugenii)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0004252; GO:0005102; GO:0005576; GO:0006508
GN012572	GN012572.1	Q5GH73	29.6	426	530	641	3.45e-42	163	XKR6_HUMAN	XK-related protein 6	Homo sapiens (Human)	apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]		plasma membrane [GO:0005886]	GO:0005886; GO:0043652; GO:0070782; GO:1902742
GN012574	GN012574.1	Q8VII6	45.4	648	646	656	7.42e-186	543	CTL1_RAT	Choline transporter-like protein 1 (Solute carrier family 44 member 1) (CD antigen CD92)	Rattus norvegicus (Rat)	choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; transmembrane transport [GO:0055085]	choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0005739; GO:0005741; GO:0005829; GO:0005886; GO:0015220; GO:0015871; GO:0016020; GO:0034228; GO:0034229; GO:0055085
GN012577	GN012577.1	Q28CB1	34.2	969	981	943	1.01e-149	471	TBD2B_XENTR	TBC1 domain family member 2B	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; early endosome [GO:0005769]	GO:0005096; GO:0005769; GO:0005829; GO:0031267
GN012578	GN012578.1	A6NDU8	36.0	236	269	294	5.36e-42	148	RIMC1_HUMAN	RAB7A-interacting MON1-CCZ1 complex subunit 1 (UPF0600 protein C5orf51)	Homo sapiens (Human)	mitophagy [GO:0000423]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0000423; GO:0005654; GO:0005829
GN012580	GN012580.1	Q6ZPJ3	29.3	1284	1339	1288	3.81e-109	378	UBE2O_MOUSE	(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O)	Mus musculus (Mouse)	positive regulation of BMP signaling pathway [GO:0030513]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; retrograde transport, endosome to Golgi [GO:0042147]	ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006513; GO:0016604; GO:0030513; GO:0042147; GO:0061630; GO:0061631; GO:0070534
GN012585	GN012585.1	O15973	46.5	370	414	499	6.06e-106	325	OPSD1_MIZYE	Rhodopsin, GQ-coupled (GQ-rhodopsin)	Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis)	visual perception [GO:0007601]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007601
GN012586	GN012586.1	G3V801	31.9	589	561	761	1.18e-76	260	NETR_RAT	Neurotrypsin (EC 3.4.21.-) (Serine protease 12)	Rattus norvegicus (Rat)	exocytosis [GO:0006887]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; synaptic cleft [GO:0043083]; terminal bouton [GO:0043195]	GO:0004252; GO:0005886; GO:0006508; GO:0006887; GO:0008233; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195; GO:0045202; GO:0098685; GO:0098793; GO:0098978
GN012587	GN012587.1	O18783	45.8	251	828	806	6.90e-62	227	PLMN_NOTEU	Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin; Plasmin heavy chain A; Plasmin light chain B; Angiostatin]	Notamacropus eugenii (Tammar wallaby) (Macropus eugenii)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0004252; GO:0005102; GO:0005576; GO:0006508
GN012588	GN012588.1	O94818	54.2	142	169	638	3.70e-43	154	NOL4_HUMAN	Nucleolar protein 4 (Nucleolar-localized protein)	Homo sapiens (Human)		RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0003723; GO:0005654; GO:0005730
GN012592	GN012592.1	O44252	32.1	140	148	275	1.59e-19	85.1	ROST_DROME	Protein rolling stone	Drosophila melanogaster (Fruit fly)	myoblast fusion [GO:0007520]		membrane [GO:0016020]	GO:0007520; GO:0016020
GN012595	GN012595.1	B6MFW3	47.1	703	687	723	1.50e-159	480	HOOK_BRAFL	Protein Hook homolog	Branchiostoma floridae (Florida lancelet) (Amphioxus)	cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent intracellular transport [GO:0030705]; endomembrane system organization [GO:0010256]	dynein light intermediate chain binding [GO:0051959]; microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytoplasm [GO:0005737]	GO:0005737; GO:0005813; GO:0008017; GO:0010256; GO:0030705; GO:0031122; GO:0051959
GN012596	GN012596.1	Q5PPX5	52.2	249	254	257	3.62e-81	247	RN170_XENLA	E3 ubiquitin-protein ligase RNF170 (EC 2.3.2.27) (RING finger protein 170) (RING-type E3 ubiquitin transferase RNF170)	Xenopus laevis (African clawed frog)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0016567; GO:0061630
GN012598	GN012598.1	Q9BYK8	27.9	1588	1594	2896	1.77e-134	467	HELZ2_HUMAN	3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 5.6.2.6) (Helicase with zinc finger 2, transcriptional coactivator) (Helicase with zinc finger domain 2) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein)	Homo sapiens (Human)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of lipid metabolic process [GO:0019216]	3'-5' RNA helicase activity [GO:0034458]; ATP hydrolysis activity [GO:0016887]; exoribonuclease II activity [GO:0008859]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; P granule [GO:0043186]	GO:0003713; GO:0003723; GO:0003724; GO:0005654; GO:0005737; GO:0005829; GO:0008859; GO:0016020; GO:0016887; GO:0019216; GO:0034458; GO:0043186; GO:0045944; GO:0046872
GN012599	GN012599.1	E9QAM5	28.2	1734	1919	2947	6.18e-161	554	HELZ2_MOUSE	3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 5.6.2.6) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1)	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of lipid metabolic process [GO:0019216]	3'-5' RNA helicase activity [GO:0034458]; ATP hydrolysis activity [GO:0016887]; exoribonuclease II activity [GO:0008859]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P granule [GO:0043186]	GO:0003723; GO:0003724; GO:0005654; GO:0005737; GO:0005829; GO:0008859; GO:0016887; GO:0019216; GO:0034458; GO:0043186; GO:0045944
GN012600	GN012600.1	E9QAM5	29.0	1670	2060	2947	3.15e-168	578	HELZ2_MOUSE	3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 5.6.2.6) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1)	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of lipid metabolic process [GO:0019216]	3'-5' RNA helicase activity [GO:0034458]; ATP hydrolysis activity [GO:0016887]; exoribonuclease II activity [GO:0008859]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P granule [GO:0043186]	GO:0003723; GO:0003724; GO:0005654; GO:0005737; GO:0005829; GO:0008859; GO:0016887; GO:0019216; GO:0034458; GO:0043186; GO:0045944
GN012601	GN012601.1	E9QAM5	28.7	1702	2112	2947	8.24e-168	578	HELZ2_MOUSE	3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 5.6.2.6) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1)	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of lipid metabolic process [GO:0019216]	3'-5' RNA helicase activity [GO:0034458]; ATP hydrolysis activity [GO:0016887]; exoribonuclease II activity [GO:0008859]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P granule [GO:0043186]	GO:0003723; GO:0003724; GO:0005654; GO:0005737; GO:0005829; GO:0008859; GO:0016887; GO:0019216; GO:0034458; GO:0043186; GO:0045944
GN012602	GN012602.1	Q9BYK8	29.5	1576	1990	2896	6.84e-158	546	HELZ2_HUMAN	3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 5.6.2.6) (Helicase with zinc finger 2, transcriptional coactivator) (Helicase with zinc finger domain 2) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein)	Homo sapiens (Human)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of lipid metabolic process [GO:0019216]	3'-5' RNA helicase activity [GO:0034458]; ATP hydrolysis activity [GO:0016887]; exoribonuclease II activity [GO:0008859]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; P granule [GO:0043186]	GO:0003713; GO:0003723; GO:0003724; GO:0005654; GO:0005737; GO:0005829; GO:0008859; GO:0016020; GO:0016887; GO:0019216; GO:0034458; GO:0043186; GO:0045944; GO:0046872
GN012603	GN012603.1	Q9UG01	61.5	52	52	1749	4.98e-17	75.5	IF172_HUMAN	Intraflagellar transport protein 172 homolog	Homo sapiens (Human)	cilium assembly [GO:0060271]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; smoothened signaling pathway [GO:0007224]		axoneme [GO:0005930]; ciliary basal body [GO:0036064]; ciliary tip [GO:0097542]; cilium [GO:0005929]; extracellular vesicle [GO:1903561]; intraciliary transport particle A [GO:0030991]; intraciliary transport particle B [GO:0030992]; sperm cytoplasmic droplet [GO:0097598]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0005929; GO:0005930; GO:0007224; GO:0030991; GO:0030992; GO:0035720; GO:0036064; GO:0042073; GO:0060271; GO:0097225; GO:0097228; GO:0097542; GO:0097598; GO:1903561
GN012604	GN012604.1	E9QAM5	40.5	153	304	2947	1.81e-30	124	HELZ2_MOUSE	3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 5.6.2.6) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1)	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of lipid metabolic process [GO:0019216]	3'-5' RNA helicase activity [GO:0034458]; ATP hydrolysis activity [GO:0016887]; exoribonuclease II activity [GO:0008859]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; P granule [GO:0043186]	GO:0003723; GO:0003724; GO:0005654; GO:0005737; GO:0005829; GO:0008859; GO:0016887; GO:0019216; GO:0034458; GO:0043186; GO:0045944
GN012605	GN012605.1	Q9BYK8	28.8	1626	1595	2896	3.31e-152	521	HELZ2_HUMAN	3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 5.6.2.6) (Helicase with zinc finger 2, transcriptional coactivator) (Helicase with zinc finger domain 2) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein)	Homo sapiens (Human)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of lipid metabolic process [GO:0019216]	3'-5' RNA helicase activity [GO:0034458]; ATP hydrolysis activity [GO:0016887]; exoribonuclease II activity [GO:0008859]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; P granule [GO:0043186]	GO:0003713; GO:0003723; GO:0003724; GO:0005654; GO:0005737; GO:0005829; GO:0008859; GO:0016020; GO:0016887; GO:0019216; GO:0034458; GO:0043186; GO:0045944; GO:0046872
GN012606	GN012606.1	Q9NWZ5	68.4	481	539	548	5.46e-225	635	UCKL1_HUMAN	Uridine-cytidine kinase-like 1 (EC 2.7.1.48)	Homo sapiens (Human)	CTP salvage [GO:0044211]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206]	ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; uridine kinase activity [GO:0004849]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004849; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0043097; GO:0043771; GO:0044206; GO:0044211
GN012607	GN012607.1	Q8BSL4	52.1	257	361	346	6.67e-92	281	HS3S5_MOUSE	Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (Heparan sulfate 3-O-sulfotransferase 5)	Mus musculus (Mouse)	heparan sulfate proteoglycan biosynthetic process [GO:0015012]; negative regulation of coagulation [GO:0050819]; protein sulfation [GO:0006477]; regulation of viral entry into host cell [GO:0046596]	[heparan sulfate]-glucosamine 3-sulfotransferase activity [GO:0008467]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006477; GO:0008467; GO:0015012; GO:0046596; GO:0050819
GN012608	GN012608.1	O75694	49.6	1382	1398	1391	0.0	1302	NU155_HUMAN	Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155)	Homo sapiens (Human)	nuclear envelope organization [GO:0006998]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus [GO:0006606]; protein localization to nuclear inner membrane [GO:0036228]; RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611]	GO:0000972; GO:0005635; GO:0005643; GO:0005829; GO:0006405; GO:0006606; GO:0006913; GO:0006998; GO:0016020; GO:0017056; GO:0031965; GO:0036228; GO:0044611
GN012609	GN012609.1	Q923W1	39.3	491	1069	853	5.22e-86	300	TGS1_MOUSE	Trimethylguanosine synthase (EC 2.1.1.-) (Cap-specific guanine-N(2) methyltransferase) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT)	Mus musculus (Mouse)	7-methylguanosine cap hypermethylation [GO:0036261]; negative regulation of protein import into nucleus [GO:0042308]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]	RNA cap trimethylguanosine synthase activity [GO:0071164]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0015030; GO:0036261; GO:0042308; GO:0061178; GO:0071164
GN012613	GN012613.1	Q3ZBK6	92.2	77	100	139	9.63e-51	159	LSM4_BOVIN	U6 snRNA-associated Sm-like protein LSm4	Bos taurus (Bovine)	mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process [GO:0000956]; P-body assembly [GO:0033962]; spliceosomal snRNP assembly [GO:0000387]	PH domain binding [GO:0042731]; U6 snRNA binding [GO:0017070]	cytosol [GO:0005829]; Lsm2-8 complex [GO:0120115]; membrane [GO:0016020]; nucleus [GO:0005634]; P-body [GO:0000932]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]	GO:0000387; GO:0000398; GO:0000932; GO:0000956; GO:0005634; GO:0005688; GO:0005829; GO:0016020; GO:0017070; GO:0033962; GO:0042731; GO:0046540; GO:0071005; GO:0097526; GO:0120115
GN012614	GN012614.1	Q6P8Y1	62.2	188	182	208	2.28e-41	141	CAPSL_MOUSE	Calcyphosin-like protein	Mus musculus (Mouse)	angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; gene expression [GO:0010467]; retina development in camera-type eye [GO:0060041]; vasculogenesis [GO:0001570]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]	GO:0001525; GO:0001570; GO:0001935; GO:0005509; GO:0005737; GO:0010467; GO:0043542; GO:0060041
GN012616	GN012616.1	Q6ZT98	50.1	811	903	887	5.18e-263	759	TTLL7_HUMAN	Tubulin polyglutamylase TTLL7 (EC 6.3.2.-) (Testis development protein NYD-SP30) (Tubulin--tyrosine ligase-like protein 7)	Homo sapiens (Human)	microtubule cytoskeleton organization [GO:0000226]; protein polyglutamylation [GO:0018095]	alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; protein-glutamic acid ligase activity, elongating [GO:0106438]; protein-glutamic acid ligase activity, initiating [GO:0106437]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	ciliary basal body [GO:0036064]; cytosol [GO:0005829]; dendrite [GO:0030425]; perikaryon [GO:0043204]	GO:0000226; GO:0005829; GO:0015631; GO:0018095; GO:0030425; GO:0036064; GO:0043014; GO:0043204; GO:0048487; GO:0070740; GO:0106437; GO:0106438
GN012617	GN012617.1	Q49LS8	28.2	156	526	578	1.08e-15	83.6	XKR6_TETNG	XK-related protein 6	Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)	apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]		plasma membrane [GO:0005886]	GO:0005886; GO:0043652; GO:0070782; GO:1902742
GN012618	GN012618.1	Q76I81	82.4	125	137	132	9.71e-73	216	RS12_BOVIN	Small ribosomal subunit protein eS12 (40S ribosomal protein S12)	Bos taurus (Bovine)	maintenance of translational fidelity [GO:1990145]; ribosomal small subunit biogenesis [GO:0042274]	structural constituent of ribosome [GO:0003735]	cytosolic small ribosomal subunit [GO:0022627]; small-subunit processome [GO:0032040]	GO:0003735; GO:0022627; GO:0032040; GO:0042274; GO:1990145
GN012619	GN012619.1	Q8BSL4	55.4	267	327	346	3.17e-107	319	HS3S5_MOUSE	Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (Heparan sulfate 3-O-sulfotransferase 5)	Mus musculus (Mouse)	heparan sulfate proteoglycan biosynthetic process [GO:0015012]; negative regulation of coagulation [GO:0050819]; protein sulfation [GO:0006477]; regulation of viral entry into host cell [GO:0046596]	[heparan sulfate]-glucosamine 3-sulfotransferase activity [GO:0008467]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006477; GO:0008467; GO:0015012; GO:0046596; GO:0050819
GN012620	GN012620.1	Q8ML92	34.1	85	153	106	6.87e-15	69.3	AVE_DROME	Protein aveugle	Drosophila melanogaster (Fruit fly)	cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; compound eye cone cell differentiation [GO:0042675]; compound eye photoreceptor cell differentiation [GO:0001751]; epidermal growth factor receptor signaling pathway [GO:0007173]; eye photoreceptor cell differentiation [GO:0001754]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of Ras protein signal transduction [GO:0046579]	scaffold protein binding [GO:0097110]	cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]	GO:0001751; GO:0001754; GO:0005737; GO:0005829; GO:0007169; GO:0007173; GO:0009898; GO:0042675; GO:0046579; GO:0070374; GO:0097110
GN012623	GN012623.1	Q9M2U3	31.2	253	263	406	1.72e-27	112	ALPL_ARATH	Protein ALP1-like (EC 3.1.-.-)	Arabidopsis thaliana (Mouse-ear cress)			histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634
GN012625	GN012625.1	Q6P8Y1	62.2	188	182	208	2.28e-41	141	CAPSL_MOUSE	Calcyphosin-like protein	Mus musculus (Mouse)	angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; gene expression [GO:0010467]; retina development in camera-type eye [GO:0060041]; vasculogenesis [GO:0001570]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]	GO:0001525; GO:0001570; GO:0001935; GO:0005509; GO:0005737; GO:0010467; GO:0043542; GO:0060041
GN012630	GN012630.1	A6NNA5	82.1	78	314	263	1.20e-31	122	DRGX_HUMAN	Dorsal root ganglia homeobox protein (Paired-related homeobox protein-like 1)	Homo sapiens (Human)	neuron development [GO:0048666]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0048666; GO:1990837
GN012631	GN012631.1	A6NNA5	82.1	78	314	263	1.20e-31	122	DRGX_HUMAN	Dorsal root ganglia homeobox protein (Paired-related homeobox protein-like 1)	Homo sapiens (Human)	neuron development [GO:0048666]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0048666; GO:1990837
GN012633	GN012633.1	Q14565	84.4	288	288	340	2.17e-177	495	DMC1_HUMAN	Meiotic recombination protein DMC1 homolog (EC 3.6.4.-)	Homo sapiens (Human)	DNA recombinase assembly [GO:0000730]; DNA strand invasion [GO:0042148]; double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; female meiosis I [GO:0007144]; homologous chromosome pairing at meiosis [GO:0007129]; male meiosis I [GO:0007141]; meiotic cell cycle [GO:0051321]; mitotic recombination [GO:0006312]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]	ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; DNA strand exchange activity [GO:0000150]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; condensed nuclear chromosome [GO:0000794]; lateral element [GO:0000800]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000150; GO:0000730; GO:0000781; GO:0000794; GO:0000800; GO:0003677; GO:0003690; GO:0003697; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0006312; GO:0007129; GO:0007131; GO:0007141; GO:0007144; GO:0007283; GO:0007292; GO:0008094; GO:0035861; GO:0042148; GO:0042802; GO:0051321; GO:0140664; GO:1990918
GN012634	GN012634.1	Q5XH16	82.3	79	79	128	1.13e-41	135	NH2L1_XENLA	NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein)	Xenopus laevis (African clawed frog)	maturation of SSU-rRNA [GO:0030490]; mRNA splicing, via spliceosome [GO:0000398]; ribosomal small subunit biogenesis [GO:0042274]	box C/D sno(s)RNA binding [GO:0034512]; U4atac snRNA binding [GO:0030622]	box C/D methylation guide snoRNP complex [GO:0031428]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; small-subunit processome [GO:0032040]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690]	GO:0000398; GO:0005634; GO:0005690; GO:0030490; GO:0030622; GO:0031428; GO:0032040; GO:0034512; GO:0042274; GO:0046540; GO:0071005; GO:0071011
GN012635	GN012635.1	P70549	38.3	899	799	927	2.19e-163	500	NAC3_RAT	Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3)	Rattus norvegicus (Rat)	calcium ion export across plasma membrane [GO:1990034]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; metal ion transport [GO:0030001]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; modulation of excitatory postsynaptic potential [GO:0098815]; myelination [GO:0042552]; negative regulation of intracellular signal transduction [GO:1902532]; oligodendrocyte differentiation [GO:0048709]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; synapse organization [GO:0050808]; telencephalon development [GO:0021537]	calcium:monoatomic cation antiporter activity [GO:0015368]; calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:1905060]; calcium:sodium antiporter activity [GO:0005432]	anchoring junction [GO:0070161]; axon [GO:0030424]; axon terminus [GO:0043679]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; synapse [GO:0045202]	GO:0002244; GO:0005432; GO:0005741; GO:0005789; GO:0005829; GO:0005874; GO:0005886; GO:0006814; GO:0006851; GO:0006874; GO:0007154; GO:0007611; GO:0007612; GO:0007613; GO:0014069; GO:0014819; GO:0015368; GO:0016528; GO:0021537; GO:0030001; GO:0030424; GO:0030425; GO:0031594; GO:0035725; GO:0042383; GO:0042552; GO:0043025; GO:0043197; GO:0043204; GO:0043679; GO:0045202; GO:0045211; GO:0048471; GO:0048709; GO:0050808; GO:0051560; GO:0060291; GO:0060402; GO:0070161; GO:0070588; GO:0071320; GO:0071456; GO:0098703; GO:0098794; GO:0098815; GO:1902532; GO:1905060; GO:1990034
GN012636	GN012636.1	S4R2P9	36.2	895	813	928	6.28e-152	471	NAC3_MOUSE	Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3)	Mus musculus (Mouse)	calcium ion export across plasma membrane [GO:1990034]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; metal ion transport [GO:0030001]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; modulation of excitatory postsynaptic potential [GO:0098815]; myelination [GO:0042552]; negative regulation of intracellular signal transduction [GO:1902532]; oligodendrocyte differentiation [GO:0048709]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; synapse organization [GO:0050808]; telencephalon development [GO:0021537]	calcium:monoatomic cation antiporter activity [GO:0015368]; calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:1905060]; calcium:sodium antiporter activity [GO:0005432]	acrosomal vesicle [GO:0001669]; anchoring junction [GO:0070161]; axon [GO:0030424]; axon terminus [GO:0043679]; centrosome [GO:0005813]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitochondrial outer membrane [GO:0005741]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; sperm end piece [GO:0097229]; synapse [GO:0045202]	GO:0001669; GO:0002244; GO:0005432; GO:0005654; GO:0005741; GO:0005789; GO:0005813; GO:0005829; GO:0005874; GO:0005886; GO:0006814; GO:0006851; GO:0006874; GO:0007154; GO:0007611; GO:0007612; GO:0007613; GO:0014069; GO:0014819; GO:0015368; GO:0015630; GO:0016528; GO:0021537; GO:0030001; GO:0030424; GO:0030425; GO:0031594; GO:0035725; GO:0042383; GO:0042552; GO:0043025; GO:0043197; GO:0043204; GO:0043679; GO:0045202; GO:0045211; GO:0048471; GO:0048709; GO:0050808; GO:0051560; GO:0060291; GO:0060402; GO:0070161; GO:0070588; GO:0071320; GO:0071456; GO:0097229; GO:0098703; GO:0098794; GO:0098815; GO:1902532; GO:1905060; GO:1990034
GN012637	GN012637.1	P20350	51.2	215	300	355	2.03e-73	232	RHOM_DROME	Protein rhomboid (EC 3.4.21.105) (Protein veinlet)	Drosophila melanogaster (Fruit fly)	axonogenesis [GO:0007409]; behavioral response to ethanol [GO:0048149]; brain development [GO:0007420]; compound eye photoreceptor fate commitment [GO:0001752]; determination of genital disc primordium [GO:0035225]; dorsal closure [GO:0007391]; epidermal growth factor receptor ligand maturation [GO:0038004]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; imaginal disc-derived wing vein specification [GO:0007474]; larval salivary gland morphogenesis [GO:0007436]; leg disc proximal/distal pattern formation [GO:0007479]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; mitotic cytokinesis [GO:0000281]; negative regulation of gene expression [GO:0010629]; negative regulation of intracellular protein transport [GO:0090317]; oenocyte development [GO:0007438]; oenocyte differentiation [GO:0001742]; photoreceptor cell fate determination [GO:0043703]; positive regulation of gene expression [GO:0010628]; positive regulation of phosphorylation [GO:0042327]; protein processing [GO:0016485]; R8 cell differentiation [GO:0045465]; regulation of circadian sleep/wake cycle [GO:0042749]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; stem cell fate commitment [GO:0048865]; tracheal pit formation in open tracheal system [GO:0035202]; wing cell fate specification [GO:0035311]	serine-type endopeptidase activity [GO:0004252]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; membrane [GO:0016020]	GO:0000139; GO:0000281; GO:0001742; GO:0001752; GO:0004252; GO:0005737; GO:0005794; GO:0007391; GO:0007409; GO:0007420; GO:0007436; GO:0007438; GO:0007474; GO:0007476; GO:0007479; GO:0008586; GO:0010628; GO:0010629; GO:0016020; GO:0016485; GO:0031902; GO:0035160; GO:0035202; GO:0035225; GO:0035311; GO:0038004; GO:0042058; GO:0042327; GO:0042749; GO:0043703; GO:0045177; GO:0045465; GO:0048149; GO:0048865; GO:0061331; GO:0090317
GN012638	GN012638.1	Q6UX73	29.1	134	172	402	5.18e-12	66.2	CP089_HUMAN	UPF0764 protein C16orf89	Homo sapiens (Human)		protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0005829; GO:0016020; GO:0042803; GO:0070062
GN012639	GN012639.1	A5PKG6	43.9	1063	1030	1067	2.65e-289	837	UBE4A_BOVIN	Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A)	Bos taurus (Bovine)	ERAD pathway [GO:0036503]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000209; GO:0005737; GO:0006511; GO:0034450; GO:0036503; GO:0061630
GN012640	GN012640.1	Q9NVX0	29.0	124	197	235	2.42e-11	63.9	HAUS2_HUMAN	HAUS augmin-like complex subunit 2 (Centrosomal protein of 27 kDa) (Cep27)	Homo sapiens (Human)	centrosome cycle [GO:0007098]; regulation of microtubule nucleation [GO:0010968]; spindle assembly [GO:0051225]		centrosome [GO:0005813]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]	GO:0005813; GO:0005829; GO:0007098; GO:0010968; GO:0051225; GO:0070652; GO:1990498
GN012641	GN012641.1	Q13045	57.2	1271	1234	1269	0.0	1229	FLII_HUMAN	Protein flightless-1 homolog	Homo sapiens (Human)	actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; myofibril assembly [GO:0030239]; sarcomere organization [GO:0045214]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	brush border [GO:0005903]; centrosome [GO:0005813]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; podosome [GO:0002102]	GO:0002102; GO:0003779; GO:0005546; GO:0005634; GO:0005813; GO:0005903; GO:0005925; GO:0008154; GO:0030239; GO:0045214; GO:0051014; GO:0051015; GO:0051016
GN012642	GN012642.1	O14981	55.6	1876	1827	1849	0.0	1869	BTAF1_HUMAN	TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172)	Homo sapiens (Human)	negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA-templated transcription [GO:0045892]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; TBP-class protein binding [GO:0017025]; transcription coregulator activity [GO:0003712]	nucleoplasm [GO:0005654]	GO:0003677; GO:0003712; GO:0005524; GO:0005654; GO:0008094; GO:0016887; GO:0017025; GO:0035562; GO:0045892
GN012644	GN012644.1	M9PH32	25.1	199	647	1206	5.17e-15	82.8	MEI26_DROME	Protein meiotic P26	Drosophila melanogaster (Fruit fly)	protein ubiquitination [GO:0016567]	ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]	GO:0004842; GO:0005737; GO:0008270; GO:0016567; GO:0036464
GN012646	GN012646.1	Q7T2X7	31.2	445	464	458	3.56e-52	185	BMP3_XENLA	Bone morphogenetic protein 3 (BMP-3) (xBMP-3)	Xenopus laevis (African clawed frog)	cell surface receptor protein serine/threonine kinase signaling pathway [GO:0007178]; osteoblast differentiation [GO:0001649]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]	extracellular region [GO:0005576]	GO:0001649; GO:0005125; GO:0005576; GO:0007178; GO:0008083
GN012647	GN012647.1	Q5PQ44	71.9	231	234	233	9.10e-112	323	CF299_XENLA	Cilia- and flagella-associated protein 299	Xenopus laevis (African clawed frog)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN012648	GN012648.1	Q9JID6	51.4	661	683	698	2.79e-240	685	ACSL1_CAVPO	Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Palmitoyl-CoA ligase) (Phytanate--CoA ligase) (EC 6.2.1.24)	Cavia porcellus (Guinea pig)	long-chain fatty acid metabolic process [GO:0001676]; very long-chain fatty acid metabolic process [GO:0000038]	arachidonate-CoA ligase activity [GO:0047676]; long-chain fatty acid-CoA ligase activity [GO:0004467]; phytanate-CoA ligase activity [GO:0050197]; pristanate-CoA ligase activity [GO:0070251]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778]	GO:0000038; GO:0001676; GO:0004467; GO:0005741; GO:0005778; GO:0005783; GO:0005789; GO:0047676; GO:0050197; GO:0070251
GN012649	GN012649.1	Q8CHU3	40.6	601	585	595	8.67e-92	297	EPN2_MOUSE	Epsin-2 (EPS-15-interacting protein 2) (Intersectin-EH-binding protein 2) (Ibp2)	Mus musculus (Mouse)	embryonic organ development [GO:0048568]; endocytosis [GO:0006897]; in utero embryonic development [GO:0001701]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of endocytosis [GO:0030100]	phospholipid binding [GO:0005543]	clathrin coat of endocytic vesicle [GO:0030128]; clathrin vesicle coat [GO:0030125]; cytoplasm [GO:0005737]; postsynaptic endocytic zone [GO:0098843]	GO:0001701; GO:0005543; GO:0005737; GO:0006897; GO:0007219; GO:0030100; GO:0030125; GO:0030128; GO:0030948; GO:0045747; GO:0048568; GO:0098843; GO:1903671
GN012652	GN012652.1	Q5ZI27	31.1	135	243	330	3.90e-10	62.4	NAIF1_CHICK	Nuclear apoptosis-inducing factor 1	Gallus gallus (Chicken)	homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705]; oogenesis [GO:0048477]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]; spermatogenesis [GO:0007283]		central element [GO:0000801]; nucleus [GO:0005634]	GO:0000801; GO:0005634; GO:0007129; GO:0007283; GO:0010705; GO:0048477; GO:1902108
GN012653	GN012653.1	Q9UN86	48.2	436	470	482	9.42e-92	290	G3BP2_HUMAN	Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)	Homo sapiens (Human)	membraneless organelle assembly [GO:0140694]; negative regulation of stress granule assembly [GO:0062030]; positive regulation of stress granule assembly [GO:0062029]; protein deubiquitination [GO:0016579]; protein homooligomerization [GO:0051260]; stress granule assembly [GO:0034063]	molecular condensate scaffold activity [GO:0140693]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]	GO:0003723; GO:0005737; GO:0005829; GO:0010494; GO:0016579; GO:0034063; GO:0051260; GO:0062029; GO:0062030; GO:0140693; GO:0140694
GN012655	GN012655.1	Q9UN86	45.0	373	405	482	2.26e-56	195	G3BP2_HUMAN	Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)	Homo sapiens (Human)	membraneless organelle assembly [GO:0140694]; negative regulation of stress granule assembly [GO:0062030]; positive regulation of stress granule assembly [GO:0062029]; protein deubiquitination [GO:0016579]; protein homooligomerization [GO:0051260]; stress granule assembly [GO:0034063]	molecular condensate scaffold activity [GO:0140693]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]	GO:0003723; GO:0005737; GO:0005829; GO:0010494; GO:0016579; GO:0034063; GO:0051260; GO:0062029; GO:0062030; GO:0140693; GO:0140694
GN012657	GN012657.1	Q9LUC8	27.2	500	503	512	1.14e-44	167	C7A13_ARATH	Cytochrome P450 72A13 (EC 1.14.-.-)	Arabidopsis thaliana (Mouse-ear cress)		heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	membrane [GO:0016020]	GO:0004497; GO:0005506; GO:0016020; GO:0016705; GO:0020037
GN012659	GN012659.1	Q5J3Q5	68.2	110	396	379	3.43e-43	157	FOXE1_XENLA	Forkhead box protein E1 (FoxE1)	Xenopus laevis (African clawed frog)	anatomical structure morphogenesis [GO:0009653]; animal organ development [GO:0048513]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]; system development [GO:0048731]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0009653; GO:0030154; GO:0043565; GO:0048513; GO:0048731
GN012660	GN012660.1	Q32LJ2	63.9	202	201	201	1.60e-89	264	ARFRP_BOVIN	ADP-ribosylation factor-related protein 1 (ARF-related protein 1)	Bos taurus (Bovine)	Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; protein localization to Golgi apparatus [GO:0034067]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0003924; GO:0005525; GO:0005794; GO:0006886; GO:0016020; GO:0034067; GO:0043001
GN012661	GN012661.1	A2VE79	60.0	145	150	172	7.77e-61	188	NUDT3_BOVIN	Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mRNA hydrolase) (EC 3.6.1.62) (m7GpppX diphosphatase) (EC 3.6.1.59)	Bos taurus (Bovine)	adenosine 5'-(hexahydrogen pentaphosphate) catabolic process [GO:1901911]; diadenosine hexaphosphate catabolic process [GO:1901909]; diadenosine pentaphosphate catabolic process [GO:1901907]; diphosphoinositol polyphosphate catabolic process [GO:0071544]; diphosphoinositol polyphosphate metabolic process [GO:0071543]; RNA decapping [GO:0110154]	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity [GO:0140932]; 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; bis(5'-adenosyl)-hexaphosphatase activity [GO:0034431]; bis(5'-adenosyl)-pentaphosphatase activity [GO:0034432]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; endopolyphosphatase activity [GO:0000298]; inositol diphosphate pentakisphosphate diphosphatase activity [GO:0052842]; inositol diphosphate tetrakisphosphate diphosphatase activity [GO:0052840]; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [GO:0052848]; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [GO:0052845]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]	GO:0000287; GO:0000298; GO:0005634; GO:0005737; GO:0008270; GO:0008486; GO:0030145; GO:0034431; GO:0034432; GO:0052840; GO:0052842; GO:0052845; GO:0052848; GO:0071543; GO:0071544; GO:0098978; GO:0110154; GO:0140932; GO:0140933; GO:1901907; GO:1901909; GO:1901911
GN012663	GN012663.1	Q9D8V0	68.8	333	368	378	1.76e-159	455	SPP_MOUSE	Signal peptide peptidase (EC 3.4.23.-) (Minor histocompatibility antigen H13) (Presenilin-like protein 3) (Signal peptide peptidase-like 1)	Mus musculus (Mouse)	in utero embryonic development [GO:0001701]; membrane protein proteolysis [GO:0033619]; retrograde protein transport, ER to cytosol [GO:0030970]	aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase binding [GO:0031625]	cell surface [GO:0009986]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]	GO:0001701; GO:0005783; GO:0005789; GO:0005791; GO:0005886; GO:0008233; GO:0009986; GO:0016020; GO:0030970; GO:0031625; GO:0033619; GO:0036513; GO:0042500; GO:0042803; GO:0098553; GO:0098554
GN012664	GN012664.1	Q0WU02	35.8	344	458	428	1.01e-61	209	MTP10_ARATH	Metal tolerance protein 10 (AtMTP10)	Arabidopsis thaliana (Mouse-ear cress)	regulation of abscisic acid-activated signaling pathway [GO:0009787]; regulation of jasmonic acid mediated signaling pathway [GO:2000022]; regulation of salicylic acid mediated signaling pathway [GO:2000031]	monoatomic cation transmembrane transporter activity [GO:0008324]	vacuolar membrane [GO:0005774]	GO:0005774; GO:0008324; GO:0009787; GO:2000022; GO:2000031
GN012667	GN012667.1	P51156	69.8	205	227	257	1.57e-104	305	RAB26_RAT	Ras-related protein Rab-26 (EC 3.6.5.2)	Rattus norvegicus (Rat)	exocrine system development [GO:0035272]; Golgi to plasma membrane protein transport [GO:0043001]; regulated exocytosis [GO:0045055]; regulation of exocytosis [GO:0017157]; regulation protein catabolic process at presynapse [GO:0140251]; vesicle-mediated transport [GO:0016192]	G protein activity [GO:0003925]; GMP binding [GO:0019002]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]	GO:0000139; GO:0003924; GO:0003925; GO:0005525; GO:0005886; GO:0016192; GO:0017157; GO:0019002; GO:0030667; GO:0030672; GO:0035272; GO:0043001; GO:0045055; GO:0140251
GN012668	GN012668.1	Q6P4Y0	72.3	509	546	553	2.94e-273	758	CDKAL_XENTR	Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		4 iron, 4 sulfur cluster binding [GO:0051539]; tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity [GO:0035598]	endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0035598; GO:0051539
GN012672	GN012672.1	Q6FLF3	45.2	305	366	544	2.04e-80	258	DBP2_CANGA	ATP-dependent RNA helicase DBP2 (EC 3.6.4.13)	Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)	nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; termination of RNA polymerase II transcription [GO:0006369]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; mRNA binding [GO:0003729]; RNA helicase activity [GO:0003724]; snoRNA binding [GO:0030515]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000184; GO:0002151; GO:0003724; GO:0003729; GO:0005524; GO:0005634; GO:0005737; GO:0006364; GO:0006369; GO:0016887; GO:0030515; GO:0051880; GO:0071042
GN012673	GN012673.1	Q2KJC6	75.8	380	410	396	7.56e-228	630	METK1_BOVIN	S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1)	Bos taurus (Bovine)	L-methionine catabolic process [GO:0009087]; S-adenosylmethionine biosynthetic process [GO:0006556]	ATP binding [GO:0005524]; methionine adenosyltransferase activity [GO:0004478]		GO:0004478; GO:0005524; GO:0006556; GO:0009087
GN012675	GN012675.1	E6ZHJ8	39.2	120	300	292	3.23e-20	91.7	FXL15_DICLA	F-box/LRR-repeat protein 15	Dicentrarchus labrax (European seabass) (Morone labrax)	bone mineralization [GO:0030282]; dorsal/ventral pattern formation [GO:0009953]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of BMP signaling pathway [GO:0030513]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]		cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005]	GO:0000086; GO:0005737; GO:0009953; GO:0016567; GO:0019005; GO:0030282; GO:0030513; GO:0031146
GN012676	GN012676.1	Q4KWL2	32.7	205	406	418	4.11e-19	92.0	ADRB2_TSCTR	Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)	Tscherskia triton (Greater long-tailed hamster)	adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-inhibiting adrenergic receptor signaling pathway [GO:0071881]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of multicellular organismal process [GO:0051241]; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0002025]; positive regulation of autophagosome maturation [GO:1901098]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cardiac muscle cell contraction [GO:0106134]; positive regulation of lipophagy [GO:1904504]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of multicellular organismal process [GO:0051240]; regulation of developmental growth [GO:0048638]; regulation of smooth muscle contraction [GO:0006940]	beta2-adrenergic receptor activity [GO:0004941]; norepinephrine binding [GO:0051380]	early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	GO:0002025; GO:0004941; GO:0005769; GO:0005794; GO:0005886; GO:0006940; GO:0010666; GO:0010667; GO:0043410; GO:0048638; GO:0051240; GO:0051241; GO:0051380; GO:0071880; GO:0071881; GO:0106134; GO:1901098; GO:1904504
GN012677	GN012677.1	Q6DJN2	37.5	232	280	556	1.23e-44	161	TRF6B_XENLA	TNF receptor-associated factor 6-B (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6-B)	Xenopus laevis (African clawed frog)	activation of NF-kappaB-inducing kinase activity [GO:0007250]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]	signaling adaptor activity [GO:0035591]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; nucleus [GO:0005634]	GO:0004842; GO:0005164; GO:0005634; GO:0005737; GO:0005811; GO:0005938; GO:0007250; GO:0008270; GO:0009898; GO:0031663; GO:0035591; GO:0042981; GO:0043122; GO:0045087; GO:0061630; GO:0070534; GO:0098978
GN012678	GN012678.1	Q9BQS2	35.7	300	457	421	1.08e-48	175	SYT15_HUMAN	Synaptotagmin-15 (Chr10Syt) (Synaptotagmin XV) (SytXV)	Homo sapiens (Human)	regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle-mediated transport [GO:0016192]	calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; SNARE binding [GO:0000149]	exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]	GO:0000149; GO:0005544; GO:0005886; GO:0016192; GO:0017158; GO:0061891; GO:0070382
GN012681	GN012681.1	Q24292	52.1	48	77	3556	8.87e-10	56.2	DS_DROME	Protein dachsous (Adherin)	Drosophila melanogaster (Fruit fly)	axonogenesis [GO:0007409]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; homophilic cell-cell adhesion [GO:0007156]; imaginal disc morphogenesis [GO:0007560]; negative regulation of hippo signaling [GO:0035331]; positive regulation of hippo signaling [GO:0035332]; protein localization involved in establishment of planar polarity [GO:0090251]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; apicolateral plasma membrane [GO:0016327]; plasma membrane [GO:0005886]	GO:0001736; GO:0005509; GO:0005886; GO:0005912; GO:0007156; GO:0007409; GO:0007560; GO:0016327; GO:0030855; GO:0035331; GO:0035332; GO:0042067; GO:0044331; GO:0070161; GO:0090251
GN012682	GN012682.1	Q9VEU1	32.3	229	214	2240	1.99e-18	86.7	CAD89_DROME	Cadherin-89D	Drosophila melanogaster (Fruit fly)	axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005912; GO:0007156; GO:0007409; GO:0016339; GO:0030855; GO:0044331
GN012683	GN012683.1	Q4V817	37.1	132	129	151	1.37e-14	68.9	CB068_XENLA	UPF0561 protein C2orf68 homolog	Xenopus laevis (African clawed frog)				
GN012684	GN012684.1	Q3TIX9	69.8	457	629	564	1.58e-234	663	UBP39_MOUSE	Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (U4/U6.U5 tri-snRNP-associated 65 kDa protein)	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]; protein deubiquitination [GO:0016579]; spliceosomal complex assembly [GO:0000245]	cysteine-type deubiquitinase activity [GO:0004843]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U12-type precatalytic spliceosome [GO:0071016]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	GO:0000245; GO:0000398; GO:0004843; GO:0005634; GO:0005654; GO:0005681; GO:0008270; GO:0016579; GO:0046540; GO:0071011; GO:0071016
GN012685	GN012685.1	Q5THR3	21.4	866	968	1501	1.64e-33	144	EFCB6_HUMAN	EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP)	Homo sapiens (Human)	androgen receptor signaling pathway [GO:0030521]; flagellated sperm motility [GO:0030317]; response to testosterone [GO:0033574]	calcium ion binding [GO:0005509]	axonemal A tubule inner sheath [GO:0160111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005509; GO:0005634; GO:0005654; GO:0030317; GO:0030521; GO:0033574; GO:0036126; GO:0160111
GN012689	GN012689.1	O97512	41.1	185	293	467	5.16e-36	137	NK3R_RABIT	Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3)	Oryctolagus cuniculus (Rabbit)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; phospholipase C-activating tachykinin receptor signaling pathway [GO:0007209]; positive regulation of flagellated sperm motility [GO:1902093]	tachykinin receptor activity [GO:0004995]	plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]	GO:0004995; GO:0005886; GO:0007189; GO:0007209; GO:0097225; GO:1902093
GN012690	GN012690.1	Q3UIK4	59.9	429	466	456	2.57e-174	499	MET14_MOUSE	N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 (Methyltransferase-like protein 14)	Mus musculus (Mouse)	forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; mRNA destabilization [GO:0061157]; mRNA export from nucleus [GO:0006406]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of hematopoietic progenitor cell differentiation [GO:1901533]; positive regulation of translation [GO:0045727]; regulation of neuron differentiation [GO:0045664]; response to nutrient levels [GO:0031667]; RNA methylation [GO:0001510]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827]	mRNA binding [GO:0003729]; mRNA m(6)A methyltransferase activity [GO:0001734]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	GO:0000398; GO:0001510; GO:0001734; GO:0003729; GO:0005634; GO:0005654; GO:0006397; GO:0006406; GO:0007283; GO:0016556; GO:0019827; GO:0021861; GO:0031667; GO:0036396; GO:0042063; GO:0045664; GO:0045727; GO:0048255; GO:0061157; GO:1901533
GN012691	GN012691.1	Q8TBZ9	31.5	232	284	253	4.84e-36	132	TEX47_HUMAN	Testis-expressed protein 47	Homo sapiens (Human)				
GN012692	GN012692.1	Q09655	38.5	231	330	371	1.97e-36	137	GPAN1_CAEEL	G patch domain and ankyrin repeat-containing protein 1 homolog	Caenorhabditis elegans		nucleic acid binding [GO:0003676]		GO:0003676
GN012696	GN012696.1	P09241	34.3	178	233	455	3.98e-32	124	OPSD_ENTDO	Rhodopsin	Enteroctopus dofleini (North Pacific giant octopus) (Octopus dofleini)	visual perception [GO:0007601]	G protein-coupled receptor activity [GO:0004930]; retinal binding [GO:0016918]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007601; GO:0016020; GO:0016918
GN012697	GN012697.1	C3ZQF9	33.4	293	315	380	1.51e-38	143	QRFPR_BRAFL	QRFP-like peptide receptor	Branchiostoma floridae (Florida lancelet) (Amphioxus)	cellular response to hormone stimulus [GO:0032870]; cellular response to peptide [GO:1901653]; G protein-coupled receptor signaling pathway [GO:0007186]	G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]	plasma membrane [GO:0005886]	GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0032870; GO:1901653
GN012698	GN012698.1	Q9H0W7	40.0	85	248	228	3.21e-09	58.9	THAP2_HUMAN	THAP domain-containing protein 2	Homo sapiens (Human)			nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730
GN012699	GN012699.1	P54646	62.0	598	590	552	2.17e-248	696	AAPK2_HUMAN	5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31)	Homo sapiens (Human)	adiponectin-activated signaling pathway [GO:0033211]; cellular response to calcium ion [GO:0071277]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to nutrient levels [GO:0031669]; cellular response to oxidative stress [GO:0034599]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; lipid biosynthetic process [GO:0008610]; lipid droplet disassembly [GO:1905691]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of hepatocyte apoptotic process [GO:1903944]; negative regulation of TOR signaling [GO:0032007]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]; positive regulation of glycolytic process [GO:0045821]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein localization [GO:1903829]; protein localization to lipid droplet [GO:1990044]; regulation of circadian rhythm [GO:0042752]; regulation of lipid metabolic process [GO:0019216]; regulation of macroautophagy [GO:0016241]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of stress granule assembly [GO:0062028]; signal transduction [GO:0007165]	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity [GO:0047322]; AMP-activated protein kinase activity [GO:0004679]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; histone H2BS36 kinase activity [GO:0140823]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]	axon [GO:0030424]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; late endosome [GO:0005770]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleotide-activated protein kinase complex [GO:0031588]; nucleus [GO:0005634]	GO:0003682; GO:0004672; GO:0004674; GO:0004679; GO:0004712; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005770; GO:0005788; GO:0005829; GO:0007165; GO:0008610; GO:0010494; GO:0010508; GO:0010629; GO:0016239; GO:0016241; GO:0016607; GO:0019216; GO:0030424; GO:0030425; GO:0031588; GO:0031669; GO:0032007; GO:0033211; GO:0034599; GO:0036064; GO:0042149; GO:0042593; GO:0042752; GO:0043025; GO:0043066; GO:0045821; GO:0047322; GO:0055089; GO:0062028; GO:0070507; GO:0071277; GO:0071333; GO:0097009; GO:0106310; GO:0140823; GO:1903829; GO:1903944; GO:1904262; GO:1905691; GO:1990044
GN012700	GN012700.1	Q3UJZ3	52.0	173	194	198	7.01e-52	168	ARMC7_MOUSE	Armadillo repeat-containing protein 7	Mus musculus (Mouse)			cytosol [GO:0005829]; U12-type catalytic step 2 spliceosome [GO:0071018]	GO:0005829; GO:0071018
GN012703	GN012703.1	Q9EQG7	42.2	303	683	477	2.02e-77	258	ENPP5_MOUSE	Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5) (EC 3.1.-.-)	Mus musculus (Mouse)	cell communication [GO:0007154]; nucleotide catabolic process [GO:0009166]	dinucleotide phosphatase activity [GO:0004551]; hydrolase activity [GO:0016787]; NAD+ diphosphatase activity [GO:0000210]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0000210; GO:0004551; GO:0005576; GO:0005886; GO:0007154; GO:0008270; GO:0009166; GO:0016787
GN012704	GN012704.1	Q9UJA9	40.8	370	376	477	1.77e-97	301	ENPP5_HUMAN	Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5) (EC 3.1.-.-)	Homo sapiens (Human)	cell communication [GO:0007154]	hydrolase activity [GO:0016787]; NAD+ diphosphatase activity [GO:0000210]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0000210; GO:0005576; GO:0005886; GO:0007154; GO:0008270; GO:0016787
GN012705	GN012705.1	Q9CQ29	30.5	200	744	239	1.30e-24	106	RN151_MOUSE	RING finger protein 151	Mus musculus (Mouse)		zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0008270
GN012706	GN012706.1	C3ZQF9	34.5	316	375	380	1.25e-57	195	QRFPR_BRAFL	QRFP-like peptide receptor	Branchiostoma floridae (Florida lancelet) (Amphioxus)	cellular response to hormone stimulus [GO:0032870]; cellular response to peptide [GO:1901653]; G protein-coupled receptor signaling pathway [GO:0007186]	G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]	plasma membrane [GO:0005886]	GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0032870; GO:1901653
GN012707	GN012707.1	A3KPQ7	29.1	892	870	1378	2.40e-91	318	CEIP2_DANRE	Cell surface hyaluronidase (EC 3.2.1.35) (Cell migration-inducing hyaluronidase 2) (Protein frozen ventricle) (Protein wickham) (Transmembrane protein 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	atrioventricular valve formation [GO:0003190]; cardiac muscle tissue morphogenesis [GO:0055008]; cell migration involved in heart formation [GO:0060974]; cell migration to the midline involved in heart development [GO:0003318]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion development [GO:0003197]; heart looping [GO:0001947]; hyaluronan catabolic process [GO:0030214]; muscle attachment [GO:0016203]; muscle tissue morphogenesis [GO:0060415]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; regulation of sprouting angiogenesis [GO:1903670]; regulation of Wnt signaling pathway [GO:0030111]	calcium ion binding [GO:0005509]; hyalurononglucosaminidase activity [GO:0004415]	plasma membrane [GO:0005886]	GO:0001947; GO:0003143; GO:0003190; GO:0003197; GO:0003318; GO:0004415; GO:0005509; GO:0005886; GO:0016203; GO:0030111; GO:0030214; GO:0055008; GO:0060415; GO:0060974; GO:1900748; GO:1901203; GO:1903670
GN012708	GN012708.1	B2GUN4	36.7	1404	1518	1681	2.57e-265	812	MARF1_XENTR	Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1 homolog)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	regulation of gene expression [GO:0010468]	RNA binding [GO:0003723]; RNA nuclease activity [GO:0004540]	peroxisome [GO:0005777]	GO:0003723; GO:0004540; GO:0005777; GO:0010468
GN012709	GN012709.1	A1L2K1	27.1	236	349	286	2.00e-15	79.0	METRL_XENLA	Meteorin-like protein	Xenopus laevis (African clawed frog)	brown fat cell differentiation [GO:0050873]; energy homeostasis [GO:0097009]; negative regulation of inflammatory response [GO:0050728]; positive regulation of brown fat cell differentiation [GO:0090336]; response to cold [GO:0009409]; response to muscle activity [GO:0014850]	hormone activity [GO:0005179]	extracellular region [GO:0005576]	GO:0005179; GO:0005576; GO:0009409; GO:0014850; GO:0050728; GO:0050873; GO:0090336; GO:0097009
GN012711	GN012711.1	Q9R1C6	45.5	483	521	564	2.07e-147	437	DGKE_MOUSE	Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon)	Mus musculus (Mouse)	diacylglycerol metabolic process [GO:0046339]; glycerolipid metabolic process [GO:0046486]; intracellular signal transduction [GO:0035556]; lipid phosphorylation [GO:0046834]; modulation of chemical synaptic transmission [GO:0050804]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	ATP-dependent diacylglycerol kinase activity [GO:0004143]; kinase activity [GO:0016301]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	GO:0004143; GO:0005654; GO:0005737; GO:0005829; GO:0006654; GO:0006661; GO:0007200; GO:0016020; GO:0016301; GO:0035556; GO:0046339; GO:0046486; GO:0046834; GO:0050804; GO:0098978
GN012715	GN012715.1	P81942	50.3	161	159	210	2.22e-46	153	GSTP1_BUFBU	Glutathione S-transferase P 1 (EC 2.5.1.18) (BBGSTP1-1) (GST class-pi)	Bufo bufo (European toad) (Rana bufo)	glutathione metabolic process [GO:0006749]	glutathione transferase activity [GO:0004364]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0004364; GO:0005634; GO:0005739; GO:0005829; GO:0006749
GN012718	GN012718.1	Q8C4J7	51.4	769	1036	801	3.81e-170	521	TBL3_MOUSE	Transducin beta-like protein 3	Mus musculus (Mouse)	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; ribosomal small subunit biogenesis [GO:0042274]	U3 snoRNA binding [GO:0034511]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	GO:0000472; GO:0000480; GO:0005654; GO:0005730; GO:0030686; GO:0032040; GO:0034511; GO:0042274
GN012719	GN012719.1	Q9CQT7	54.5	143	468	168	7.18e-52	176	DESI1_MOUSE	Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Palmitoyl protein thioesterase DESI1) (EC 3.1.2.22) (S-depalmitoylase DESI1)	Mus musculus (Mouse)	protein desumoylation [GO:0016926]; protein export from nucleus [GO:0006611]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]	deSUMOylase activity [GO:0016929]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; palmitoyl-(protein) hydrolase activity [GO:0008474]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0005634; GO:0005737; GO:0005829; GO:0006611; GO:0008474; GO:0016926; GO:0016929; GO:0032434; GO:0032991; GO:0042802; GO:0052816; GO:0061676
GN012720	GN012720.1	Q6P1R4	56.3	455	547	473	6.10e-183	525	DUS1L_HUMAN	tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC 1.3.1.88) (tRNA-dihydrouridine synthase 1-like)	Homo sapiens (Human)	tRNA dihydrouridine synthesis [GO:0002943]	flavin adenine dinucleotide binding [GO:0050660]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine16 synthase activity [GO:0102262]; tRNA-dihydrouridine17 synthase activity [GO:0102263]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0002943; GO:0005634; GO:0005737; GO:0017150; GO:0050660; GO:0102262; GO:0102263
GN012721	GN012721.1	Q29466	54.7	908	899	838	0.0	926	VPP1_BOVIN	V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)	Bos taurus (Bovine)	pH reduction [GO:0045851]; proton transmembrane transport [GO:1902600]; vacuolar acidification [GO:0007035]	ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	clathrin-coated vesicle membrane [GO:0030665]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	GO:0000220; GO:0005886; GO:0007035; GO:0016471; GO:0030665; GO:0030672; GO:0042470; GO:0045851; GO:0046961; GO:0051117; GO:1902600
GN012722	GN012722.1	Q6NRT5	74.6	472	484	487	1.33e-246	685	CSN1_XENLA	COP9 signalosome complex subunit 1 (Signalosome subunit 1)	Xenopus laevis (African clawed frog)			COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]	GO:0005737; GO:0008180
GN012730	GN012730.1	Q8NFZ3	31.5	531	513	816	7.87e-69	239	NLGNY_HUMAN	Neuroligin-4, Y-linked (Neuroligin Y)	Homo sapiens (Human)	learning [GO:0007612]; neuron cell-cell adhesion [GO:0007158]; presynapse assembly [GO:0099054]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625]	cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; neurexin family protein binding [GO:0042043]; scaffold protein binding [GO:0097110]	asymmetric, glutamatergic, excitatory synapse [GO:0098985]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic specialization membrane [GO:0099634]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]	GO:0005886; GO:0007158; GO:0007416; GO:0007612; GO:0016020; GO:0030425; GO:0035176; GO:0042043; GO:0043197; GO:0045202; GO:0050839; GO:0071625; GO:0097110; GO:0098631; GO:0098839; GO:0098983; GO:0098985; GO:0099054; GO:0099634
GN012731	GN012731.1	Q6UWM5	35.9	145	209	242	5.31e-19	85.1	GPRL1_HUMAN	GLIPR1-like protein 1	Homo sapiens (Human)	fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]		acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein complex involved in cell-cell adhesion [GO:0098635]	GO:0001669; GO:0005576; GO:0005886; GO:0007342; GO:0045121; GO:0098635
GN012732	GN012732.1	Q5R7Y0	22.9	328	1368	1485	1.24e-09	67.0	AGRB2_PONAB	Adhesion G protein-coupled receptor B2 (Brain-specific angiogenesis inhibitor 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	calcineurin-NFAT signaling cascade [GO:0033173]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of angiogenesis [GO:0016525]	G protein-coupled receptor activity [GO:0004930]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0004930; GO:0005576; GO:0005886; GO:0007166; GO:0007186; GO:0016525; GO:0033173
GN012734	GN012734.1	Q9JKF8	51.7	263	310	280	6.80e-81	249	RASD1_RAT	Dexamethasone-induced Ras-related protein 1	Rattus norvegicus (Rat)	cellular response to nitric oxide [GO:0071732]; intracellular signaling cassette [GO:0141124]; negative regulation of DNA-templated transcription [GO:0045892]; NMDA selective glutamate receptor signaling pathway [GO:0098989]; signal transduction [GO:0007165]	G-protein beta-subunit binding [GO:0031681]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]	GO:0003924; GO:0005525; GO:0005634; GO:0005737; GO:0005886; GO:0007165; GO:0016529; GO:0031681; GO:0045892; GO:0048471; GO:0071732; GO:0098989; GO:0141124
GN012736	GN012736.1	Q9DDJ0	88.3	137	192	157	1.18e-95	277	UBC9B_DANRE	SUMO-conjugating enzyme UBC9-B (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9-B) (SUMO-protein ligase B) (Ubiquitin carrier protein 9-B) (Ubiquitin carrier protein I-B) (Ubiquitin-conjugating enzyme E2 I-B) (Ubiquitin-protein ligase I-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	definitive hemopoiesis [GO:0060216]; embryonic heart tube elongation [GO:0036306]; heart looping [GO:0001947]; protein sumoylation [GO:0016925]	SUMO conjugating enzyme activity [GO:0061656]	nucleus [GO:0005634]	GO:0001947; GO:0005634; GO:0016925; GO:0036306; GO:0060216; GO:0061656
GN012737	GN012737.1	Q6NUQ1	41.8	741	751	792	1.30e-188	559	RINT1_HUMAN	RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1)	Homo sapiens (Human)	mitotic G2 DNA damage checkpoint signaling [GO:0007095]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]		cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0005829; GO:0006890; GO:0007095; GO:0060628; GO:0070939
GN012738	GN012738.1	Q1JP75	56.0	243	244	244	3.20e-91	271	DCXR_BOVIN	L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) (DCXR)	Bos taurus (Bovine)	glucose metabolic process [GO:0006006]; xylulose metabolic process [GO:0005997]	carbonyl reductase (NADPH) activity [GO:0004090]; L-xylulose reductase (NADPH) activity [GO:0050038]	acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; cytoplasmic microtubule [GO:0005881]	GO:0001669; GO:0004090; GO:0005881; GO:0005997; GO:0006006; GO:0016324; GO:0050038
GN012739	GN012739.1	G3V8Y7	33.7	365	356	569	1.34e-37	145	AP4AT_RAT	AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Tetra-epsin)	Rattus norvegicus (Rat)		protein-containing complex binding [GO:0044877]	coated vesicle membrane [GO:0030662]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; trans-Golgi network membrane [GO:0032588]	GO:0005737; GO:0005829; GO:0030662; GO:0031410; GO:0032588; GO:0044877
GN012742	GN012742.1	Q9BYK8	28.0	2843	3827	2896	1.86e-278	926	HELZ2_HUMAN	3'-5' exoribonuclease HELZ2 (EC 3.1.13.1) (ATP-dependent RNA helicase PRIC285) (EC 5.6.2.6) (Helicase with zinc finger 2, transcriptional coactivator) (Helicase with zinc finger domain 2) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein)	Homo sapiens (Human)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of lipid metabolic process [GO:0019216]	3'-5' RNA helicase activity [GO:0034458]; ATP hydrolysis activity [GO:0016887]; exoribonuclease II activity [GO:0008859]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; P granule [GO:0043186]	GO:0003713; GO:0003723; GO:0003724; GO:0005654; GO:0005737; GO:0005829; GO:0008859; GO:0016020; GO:0016887; GO:0019216; GO:0034458; GO:0043186; GO:0045944; GO:0046872
GN012743	GN012743.1	Q8BMA6	52.3	488	558	625	3.29e-155	461	SRP68_MOUSE	Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein)	Mus musculus (Mouse)	response to xenobiotic stimulus [GO:0009410]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; protein domain specific binding [GO:0019904]; ribosome binding [GO:0043022]; signal recognition particle binding [GO:0005047]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]	GO:0005047; GO:0005730; GO:0005737; GO:0005783; GO:0005786; GO:0005829; GO:0005925; GO:0006614; GO:0008312; GO:0009410; GO:0019904; GO:0030942; GO:0043022; GO:0048500
GN012744	GN012744.1	Q5PPN5	41.3	184	177	176	8.30e-20	84.7	TPPP3_RAT	Tubulin polymerization-promoting protein family member 3	Rattus norvegicus (Rat)	decidualization [GO:0046697]; embryo implantation [GO:0007566]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; positive regulation of protein polymerization [GO:0032273]	tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; microtubule bundle [GO:0097427]; perinuclear region of cytoplasm [GO:0048471]	GO:0001578; GO:0005737; GO:0007566; GO:0015631; GO:0032273; GO:0046697; GO:0046785; GO:0048471; GO:0097427
GN012745	GN012745.1	Q24562	75.6	381	443	416	2.38e-207	581	U2AF2_DROME	Splicing factor U2AF 50 kDa subunit (U2 auxiliary factor 50 kDa subunit) (U2 snRNP auxiliary factor large subunit)	Drosophila melanogaster (Fruit fly)	mRNA splicing, via spliceosome [GO:0000398]; nuclear export [GO:0051168]; positive regulation of RNA export from nucleus [GO:0046833]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]	mRNA binding [GO:0003729]; poly-pyrimidine tract binding [GO:0008187]; pre-mRNA 3'-splice site binding [GO:0030628]; RNA binding [GO:0003723]	commitment complex [GO:0000243]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U2-type prespliceosome [GO:0071004]; U2AF complex [GO:0089701]	GO:0000243; GO:0000245; GO:0000381; GO:0000398; GO:0003723; GO:0003729; GO:0005634; GO:0005654; GO:0005681; GO:0008187; GO:0008380; GO:0030628; GO:0046833; GO:0048024; GO:0051168; GO:0071004; GO:0071011; GO:0089701
GN012746	GN012746.1	A3RLT6	83.6	299	321	301	8.82e-174	486	RSSA_PINFU	Small ribosomal subunit protein uS2 (40S ribosomal protein SA)	Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata)	ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	cytosolic small ribosomal subunit [GO:0022627]	GO:0000028; GO:0003735; GO:0006412; GO:0022627
GN012749	GN012749.1	P00516	73.3	591	683	671	0.0	893	KGP1_BOVIN	cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI)	Bos taurus (Bovine)	negative regulation of platelet aggregation [GO:0090331]; signal transduction [GO:0007165]	ATP binding [GO:0005524]; calcium channel regulator activity [GO:0005246]; cGMP-dependent protein kinase activity [GO:0004692]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004692; GO:0005246; GO:0005524; GO:0005737; GO:0005829; GO:0007165; GO:0042802; GO:0090331; GO:0106310
GN012751	GN012751.1	Q2KIR0	34.3	102	206	197	8.46e-10	59.3	SMIP2_BOVIN	Protein SPMIP2	Bos taurus (Bovine)				
GN012752	GN012752.1	Q9P0S9	59.8	92	113	112	8.56e-31	108	TM14C_HUMAN	Transmembrane protein 14C	Homo sapiens (Human)	heme biosynthetic process [GO:0006783]		mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	GO:0005739; GO:0006783; GO:0031966
GN012753	GN012753.1	Q9UPM9	69.4	183	207	204	4.99e-100	291	B9D1_HUMAN	B9 domain-containing protein 1 (MKS1-related protein 1)	Homo sapiens (Human)	cilium assembly [GO:0060271]; protein localization to ciliary transition zone [GO:1904491]; smoothened signaling pathway [GO:0007224]	hedgehog receptor activity [GO:0008158]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; membrane [GO:0016020]; MKS complex [GO:0036038]	GO:0005813; GO:0005829; GO:0005930; GO:0007224; GO:0008158; GO:0016020; GO:0035869; GO:0036038; GO:0036064; GO:0060271; GO:1904491
GN012754	GN012754.1	P08133	45.6	654	908	673	2.12e-188	560	ANXA6_HUMAN	Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70)	Homo sapiens (Human)	apoptotic signaling pathway [GO:0097190]; calcium ion transport [GO:0006816]; mitochondrial calcium ion homeostasis [GO:0051560]; monoatomic ion transmembrane transport [GO:0034220]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; cholesterol binding [GO:0015485]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; ligand-gated monoatomic ion channel activity [GO:0015276]; lipid binding [GO:0008289]; phosphatidylserine binding [GO:0001786]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; focal adhesion [GO:0005925]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]	GO:0001786; GO:0005509; GO:0005525; GO:0005544; GO:0005634; GO:0005739; GO:0005765; GO:0005886; GO:0005925; GO:0006816; GO:0008289; GO:0012506; GO:0015276; GO:0015485; GO:0016020; GO:0031012; GO:0031902; GO:0034220; GO:0042470; GO:0042802; GO:0048306; GO:0051560; GO:0070062; GO:0097190
GN012758	GN012758.1	Q8R010	35.7	277	278	320	7.72e-40	144	AIMP2_MOUSE	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1)	Mus musculus (Mouse)	negative regulation of cell population proliferation [GO:0008285]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein ubiquitination [GO:0031398]; protein-containing complex assembly [GO:0065003]; type II pneumocyte differentiation [GO:0060510]	molecular adaptor activity [GO:0060090]; protein-macromolecule adaptor activity [GO:0030674]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0008285; GO:0017101; GO:0030674; GO:0031398; GO:0043525; GO:0060090; GO:0060510; GO:0065003
GN012760	GN012760.1	Q5PQN1	52.1	1059	1053	1057	0.0	1003	HERC4_RAT	Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4)	Rattus norvegicus (Rat)	negative regulation of smoothened signaling pathway [GO:0045879]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]	GO:0005829; GO:0006511; GO:0007283; GO:0016567; GO:0045879; GO:0061630
GN012762	GN012762.1	Q12830	29.3	3010	2597	3046	5.46e-238	795	BPTF_HUMAN	Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen)	Homo sapiens (Human)	brain development [GO:0007420]; cellular response to nerve growth factor stimulus [GO:1990090]; chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	sequence-specific DNA binding [GO:0043565]	ATPase complex [GO:1904949]; cell body [GO:0044297]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]; perinuclear region of cytoplasm [GO:0048471]	GO:0000122; GO:0000785; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006338; GO:0006355; GO:0006357; GO:0007420; GO:0016589; GO:0030425; GO:0043565; GO:0044297; GO:0045944; GO:0048471; GO:0070062; GO:1904949; GO:1990090
GN012763	GN012763.1	Q8TBF5	33.8	133	169	258	3.46e-15	73.9	PIGX_HUMAN	GPI alpha-1,4-mannosyltransferase I, stabilizing subunit (Phosphatidylinositol-glycan biosynthesis class X protein) (PIG-X)	Homo sapiens (Human)	GPI anchor biosynthetic process [GO:0006506]		endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-mannosyltransferase I complex [GO:1990529]	GO:0005789; GO:0006506; GO:1990529
GN012764	GN012764.1	Q6GMA4	62.9	170	206	200	9.42e-66	204	CHM6A_XENLA	Charged multivesicular body protein 6-A (Chromatin-modifying protein 6-A)	Xenopus laevis (African clawed frog)	late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; nuclear membrane reassembly [GO:0031468]; vesicle budding from membrane [GO:0006900]		ESCRT III complex [GO:0000815]; late endosome membrane [GO:0031902]; multivesicular body [GO:0005771]; nuclear envelope [GO:0005635]	GO:0000815; GO:0005635; GO:0005771; GO:0006900; GO:0031468; GO:0031902; GO:0032511
GN012765	GN012765.1	Q3T0W7	67.8	87	118	140	1.11e-40	134	ATG12_BOVIN	Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like)	Bos taurus (Bovine)	autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; autophagy of mitochondrion [GO:0000422]; glycophagy [GO:0061723]; piecemeal microautophagy of the nucleus [GO:0034727]	protein tag activity [GO:0031386]	Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome membrane [GO:0000421]; phagophore assembly site membrane [GO:0034045]	GO:0000045; GO:0000421; GO:0000422; GO:0031386; GO:0034045; GO:0034274; GO:0034727; GO:0061723; GO:0097352
GN012766	GN012766.1	F1SS88	50.5	653	660	620	2.26e-221	633	CFA52_PIG	Cilia- and flagella-associated protein 52 (WD repeat-containing protein 16)	Sus scrofa (Pig)	establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]		9+2 motile cilium [GO:0097729]; axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]	GO:0005737; GO:0005879; GO:0005930; GO:0030317; GO:0036126; GO:0061966; GO:0097225; GO:0097729; GO:0160112
GN012767	GN012767.1	P85037	57.4	406	681	733	2.95e-137	422	FOXK1_HUMAN	Forkhead box protein K1 (Myocyte nuclear factor) (MNF)	Homo sapiens (Human)	canonical glycolysis [GO:0061621]; intracellular glucose homeostasis [GO:0001678]; negative regulation of autophagy [GO:0010507]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription by RNA polymerase II [GO:0006357]; response to starvation [GO:0042594]	14-3-3 protein binding [GO:0071889]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000976; GO:0000978; GO:0000981; GO:0001227; GO:0001678; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0010507; GO:0010906; GO:0042594; GO:0045892; GO:0045893; GO:0061621; GO:0071889; GO:1990837
GN012768	GN012768.1	Q5PPV2	50.6	453	452	446	6.86e-138	406	TEKT4_XENLA	Tektin-4	Xenopus laevis (African clawed frog)	cilium assembly [GO:0060271]; cilium movement involved in cell motility [GO:0060294]		axonemal microtubule [GO:0005879]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005634; GO:0005879; GO:0015630; GO:0036126; GO:0060271; GO:0060294
GN012770	GN012770.1	Q80YR5	57.5	80	1368	991	5.23e-19	97.4	SAFB2_MOUSE	Scaffold attachment factor B2 (SAF-B2)	Mus musculus (Mouse)	regulation of androgen receptor signaling pathway [GO:0060765]; Sertoli cell differentiation [GO:0060008]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0016604; GO:0042802; GO:0060008; GO:0060765
GN012771	GN012771.1	Q6P4T1	26.6	887	856	997	3.94e-50	194	SNX19_MOUSE	Sorting nexin-19	Mus musculus (Mouse)	chondrocyte differentiation [GO:0002062]; dense core granule maturation [GO:1990502]; insulin secretion [GO:0030073]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]	cytoplasmic vesicle membrane [GO:0030659]; early endosome membrane [GO:0031901]	GO:0002062; GO:0030073; GO:0030659; GO:0031901; GO:0032266; GO:0035091; GO:1990502
GN012772	GN012772.1	Q3MHR5	73.6	106	208	221	2.10e-49	163	SRSF2_BOVIN	Serine/arginine-rich splicing factor 2 (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)	Bos taurus (Bovine)	regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	pre-mRNA binding [GO:0036002]	nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681]	GO:0000381; GO:0005681; GO:0016607; GO:0036002
GN012773	GN012773.1	P30352	72.5	120	272	221	1.51e-52	173	SRSF2_CHICK	Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)	Gallus gallus (Chicken)	regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	pre-mRNA binding [GO:0036002]	nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681]	GO:0000381; GO:0005681; GO:0016607; GO:0036002
GN012774	GN012774.1	A2VDL9	63.6	412	460	407	2.69e-165	474	T184B_BOVIN	Transmembrane protein 184B	Bos taurus (Bovine)		transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0016020; GO:0022857
GN012775	GN012775.1	Q05A80	37.7	130	254	1031	1.39e-16	82.4	CAPR2_MOUSE	Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (RNA granule protein 140)	Mus musculus (Mouse)	negative regulation of cell growth [GO:0030308]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of transcription by RNA polymerase II [GO:0045944]	signaling receptor binding [GO:0005102]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0005102; GO:0005654; GO:0005737; GO:0005739; GO:0005813; GO:0005829; GO:0005886; GO:0030308; GO:0043235; GO:0045944; GO:0050775; GO:0061003; GO:0090263
GN012776	GN012776.1	P51892	72.4	653	753	1070	0.0	980	DNLI1_XENLA	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1)	Xenopus laevis (African clawed frog)	DNA biosynthetic process [GO:0071897]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; lagging strand elongation [GO:0006273]; Okazaki fragment processing involved in mitotic DNA replication [GO:1903461]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA ligase (ATP) activity [GO:0003910]	mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0003677; GO:0003910; GO:0005524; GO:0005634; GO:0005739; GO:0006273; GO:0006281; GO:0006310; GO:0071897; GO:1903461
GN012777	GN012777.1	P50616	48.8	244	381	345	1.51e-58	196	TOB1_HUMAN	Protein Tob1 (Transducer of erbB-2 1)	Homo sapiens (Human)	negative regulation of cell population proliferation [GO:0008285]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; negative regulation of translation [GO:0017148]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of gene expression [GO:0010468]	receptor tyrosine kinase binding [GO:0030971]; SMAD binding [GO:0046332]; transcription corepressor activity [GO:0003714]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003714; GO:0005634; GO:0005737; GO:0008285; GO:0010468; GO:0017148; GO:0030014; GO:0030971; GO:0046332; GO:0060212; GO:0060213; GO:1900153
GN012779	GN012779.1	A1L1L6	60.1	582	647	631	3.59e-257	724	MIRO1_RAT	Mitochondrial Rho GTPase (MIRO-1) (EC 3.6.5.-) (Ras homolog gene family member T1)	Rattus norvegicus (Rat)	antiviral innate immune response [GO:0140374]; cellular homeostasis [GO:0019725]; establishment of mitochondrion localization by microtubule attachment [GO:0034640]; free ubiquitin chain polymerization [GO:0010994]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrion transport along microtubule [GO:0047497]; positive regulation of interferon-beta production [GO:0032728]; protein homooligomerization [GO:0051260]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of innate immune response [GO:0045088]; regulation of mitochondrion organization [GO:0010821]; regulation of neurotransmitter secretion [GO:0046928]; regulation of organelle transport along microtubule [GO:1902513]; RIG-I signaling pathway [GO:0039529]	ATP hydrolysis activity [GO:0016887]; calcium ion binding [GO:0005509]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; ribonucleoprotein complex binding [GO:0043021]; RIG-I binding [GO:0039552]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; mitochondrial outer membrane [GO:0005741]; ribonucleoprotein complex [GO:1990904]	GO:0000209; GO:0000287; GO:0003924; GO:0004842; GO:0005509; GO:0005525; GO:0005737; GO:0005741; GO:0010494; GO:0010821; GO:0010994; GO:0016567; GO:0016887; GO:0019003; GO:0019725; GO:0032728; GO:0034640; GO:0039529; GO:0039552; GO:0042802; GO:0043021; GO:0045088; GO:0046928; GO:0047497; GO:0051260; GO:0061630; GO:0070534; GO:0097345; GO:0140374; GO:1902513; GO:1990904
GN012780	GN012780.1	Q9BTW9	46.2	93	117	1192	2.15e-24	99.8	TBCD_HUMAN	Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D)	Homo sapiens (Human)	adherens junction assembly [GO:0034333]; bicellular tight junction assembly [GO:0070830]; cell morphogenesis involved in neuron differentiation [GO:0048667]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of microtubule polymerization [GO:0031115]; post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]	beta-tubulin binding [GO:0048487]; GTPase activator activity [GO:0005096]; protein-folding chaperone binding [GO:0051087]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]	GO:0000226; GO:0000278; GO:0005096; GO:0005737; GO:0005813; GO:0005874; GO:0005912; GO:0005923; GO:0006457; GO:0007021; GO:0007023; GO:0010812; GO:0016328; GO:0031115; GO:0034333; GO:0048487; GO:0048667; GO:0051087; GO:0070830
GN012782	GN012782.1	Q6AI12	63.4	82	158	368	1.81e-24	100	ANR40_HUMAN	Ankyrin repeat domain-containing protein 40	Homo sapiens (Human)				
GN012783	GN012783.1	Q9D1P2	79.5	405	490	458	1.56e-237	661	KAT8_MOUSE	Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (mMof) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-)	Mus musculus (Mouse)	dosage compensation by inactivation of X chromosome [GO:0009048]; epithelial to mesenchymal transition [GO:0001837]; membraneless organelle assembly [GO:0140694]; myeloid cell differentiation [GO:0030099]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of type I interferon production [GO:0032480]; neurogenesis [GO:0022008]; oogenesis [GO:0048477]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of skeletal muscle satellite cell differentiation [GO:1902726]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; positive regulation of type I interferon production [GO:0032481]; post-embryonic hemopoiesis [GO:0035166]; regulation of autophagy [GO:0010506]; regulation of mitochondrial transcription [GO:1903108]; regulation of mRNA processing [GO:0050684]; transcription initiation-coupled chromatin remodeling [GO:0045815]	acetyltransferase activity [GO:0016407]; enzyme binding [GO:0019899]; histone acetyltransferase activity [GO:0004402]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K16 acetyltransferase activity [GO:0046972]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; promoter-specific chromatin binding [GO:1990841]; protein propionyltransferase activity [GO:0061920]; protein-lysine-acetyltransferase activity [GO:0061733]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]	chromosome [GO:0005694]; histone acetyltransferase complex [GO:0000123]; kinetochore [GO:0000776]; mitochondrion [GO:0005739]; MLL1 complex [GO:0071339]; MSL complex [GO:0072487]; NSL complex [GO:0044545]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000123; GO:0000776; GO:0001837; GO:0003713; GO:0004402; GO:0005634; GO:0005654; GO:0005694; GO:0005739; GO:0009048; GO:0010485; GO:0010506; GO:0010718; GO:0010719; GO:0016363; GO:0016407; GO:0019899; GO:0022008; GO:0030099; GO:0032480; GO:0032481; GO:0035166; GO:0035267; GO:0043995; GO:0043996; GO:0044545; GO:0045815; GO:0045892; GO:0045893; GO:0046972; GO:0048477; GO:0050684; GO:0060261; GO:0061629; GO:0061733; GO:0061920; GO:0071339; GO:0072487; GO:0140694; GO:1902726; GO:1903108; GO:1990841
GN012784	GN012784.1	Q08629	32.4	207	214	439	4.32e-26	107	TICN1_HUMAN	Testican-1 (Protein SPOCK)	Homo sapiens (Human)	cell adhesion [GO:0007155]; central nervous system neuron differentiation [GO:0021953]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; regulation of cell growth [GO:0001558]; regulation of cell-substrate adhesion [GO:0010810]	calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; extracellular matrix structural constituent [GO:0005201]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; gel phase of interstitial matrix [GO:0140150]; neuromuscular junction [GO:0031594]; node of Ranvier [GO:0033268]; postsynaptic density [GO:0014069]; sarcoplasm [GO:0016528]	GO:0001558; GO:0001764; GO:0004867; GO:0004869; GO:0005201; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0007399; GO:0008191; GO:0010810; GO:0010812; GO:0010977; GO:0014069; GO:0016528; GO:0021953; GO:0022008; GO:0031012; GO:0031594; GO:0033268; GO:0140150
GN012785	GN012785.1	Q9D9B4	49.8	223	258	229	1.06e-64	204	LRMDA_MOUSE	Leucine-rich melanocyte differentiation-associated protein	Mus musculus (Mouse)	melanocyte differentiation [GO:0030318]		nucleoplasm [GO:0005654]	GO:0005654; GO:0030318
GN012786	GN012786.1	Q5ZM33	35.5	183	679	559	4.48e-24	110	HP1B3_CHICK	Heterochromatin protein 1-binding protein 3	Gallus gallus (Chicken)	heterochromatin organization [GO:0070828]; nucleosome assembly [GO:0006334]	DNA binding [GO:0003677]; nucleosome binding [GO:0031491]	chromosome [GO:0005694]; nucleosome [GO:0000786]; nucleus [GO:0005634]	GO:0000786; GO:0003677; GO:0005634; GO:0005694; GO:0006334; GO:0031491; GO:0070828
GN012787	GN012787.1	P42125	51.5	97	99	289	2.73e-25	98.6	ECI1_MOUSE	Enoyl-CoA delta isomerase 1, mitochondrial (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase)	Mus musculus (Mouse)	fatty acid beta-oxidation [GO:0006635]	delta(3)-delta(2)-enoyl-CoA isomerase activity [GO:0004165]; identical protein binding [GO:0042802]; intramolecular oxidoreductase activity, transposing C=C bonds [GO:0016863]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004165; GO:0005739; GO:0005743; GO:0005759; GO:0006635; GO:0016863; GO:0042802
GN012791	GN012791.1	Q7TN88	33.9	109	640	2461	3.85e-11	70.5	PK1L2_MOUSE	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Mus musculus (Mouse)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]	membrane [GO:0016020]	GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN012794	GN012794.1	Q7TN88	30.3	1190	3503	2461	2.36e-144	510	PK1L2_MOUSE	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Mus musculus (Mouse)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]	membrane [GO:0016020]	GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN012795	GN012795.1	Q9Z306	27.4	387	513	553	1.34e-30	128	S22A4_MOUSE	Solute carrier family 22 member 4 (Organic cation/carnitine transporter 1) (Octn1)	Mus musculus (Mouse)	acetylcholine uptake [GO:0051630]; amino acid import across plasma membrane [GO:0089718]; carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879]; lactation [GO:0007595]; liver regeneration [GO:0097421]; quaternary ammonium group transport [GO:0015697]; response to exogenous dsRNA [GO:0043330]; response to lipopolysaccharide [GO:0032496]; response to vitamin D [GO:0033280]; sodium-independent organic anion transport [GO:0043252]; sulfur amino acid transport [GO:0000101]; triglyceride metabolic process [GO:0006641]; xenobiotic transport [GO:0042908]	acetylcholine transmembrane transporter activity [GO:0005277]; amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]	GO:0000101; GO:0005277; GO:0005739; GO:0006641; GO:0007595; GO:0009437; GO:0009925; GO:0015171; GO:0015199; GO:0015226; GO:0015651; GO:0015697; GO:0015879; GO:0016324; GO:0030165; GO:0031966; GO:0032496; GO:0033280; GO:0042908; GO:0043025; GO:0043252; GO:0043330; GO:0051630; GO:0089718; GO:0097421
GN012796	GN012796.1	A7E305	41.0	932	898	1413	7.25e-170	534	ZSWM8_BOVIN	Zinc finger SWIM domain-containing protein 8	Bos taurus (Bovine)	positive regulation of miRNA catabolic process [GO:2000627]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]	GO:0005829; GO:0008270; GO:0016567; GO:0031462; GO:0031463; GO:0043161; GO:1990756; GO:2000627
GN012797	GN012797.1	A7E2V4	48.9	1004	1099	1837	3.03e-258	784	ZSWM8_HUMAN	Zinc finger SWIM domain-containing protein 8	Homo sapiens (Human)	positive regulation of miRNA catabolic process [GO:2000627]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein ubiquitination [GO:0016567]; target-directed miRNA degradation [GO:0140958]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; zinc ion binding [GO:0008270]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]	GO:0005829; GO:0006515; GO:0008270; GO:0016567; GO:0031462; GO:0031463; GO:0043161; GO:0140958; GO:1990756; GO:2000627
GN012798	GN012798.1	P62265	90.7	151	150	151	2.34e-92	267	RS14_CRIGR	Small ribosomal subunit protein uS11 (40S ribosomal protein S14)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	cytoplasmic translation [GO:0002181]; erythrocyte differentiation [GO:0030218]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ribosomal small subunit biogenesis [GO:0042274]	mRNA 5'-UTR binding [GO:0048027]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; postsynaptic density [GO:0014069]; small-subunit processome [GO:0032040]	GO:0000122; GO:0002181; GO:0003735; GO:0005737; GO:0005783; GO:0014069; GO:0022627; GO:0030218; GO:0032040; GO:0042274; GO:0048027
GN012799	GN012799.1	P51688	61.6	479	510	502	1.14e-217	613	SPHM_HUMAN	N-sulphoglucosamine sulphohydrolase (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase)	Homo sapiens (Human)	glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]	N-sulfoglucosamine sulfohydrolase activity [GO:0016250]; sulfuric ester hydrolase activity [GO:0008484]	extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	GO:0005764; GO:0006027; GO:0008484; GO:0016250; GO:0030200; GO:0043202; GO:0070062
GN012800	GN012800.1	Q5ZI11	44.4	664	675	670	1.86e-132	408	LRC45_CHICK	Leucine-rich repeat-containing protein 45	Gallus gallus (Chicken)			centrosome [GO:0005813]	GO:0005813
GN012802	GN012802.1	Q8ZXT3	30.2	149	780	182	1.91e-13	72.8	Y1111_PYRAE	Uncharacterized protein PAE1111	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)				
GN012803	GN012803.1	P35951	37.8	399	835	862	1.01e-82	286	LDLR_MOUSE	Low-density lipoprotein receptor (LDL receptor)	Mus musculus (Mouse)	amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; artery development [GO:0060840]; artery morphogenesis [GO:0048844]; cellular response to fatty acid [GO:0071398]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; high-density lipoprotein particle clearance [GO:0034384]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; lipoprotein metabolic process [GO:0042157]; long-term memory [GO:0007616]; low-density lipoprotein particle clearance [GO:0034383]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of astrocyte activation [GO:0061889]; negative regulation of gene expression [GO:0010629]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of receptor recycling [GO:0001920]; phagocytosis [GO:0006909]; phospholipid transport [GO:0015914]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of lysosomal protein catabolic process [GO:1905167]; positive regulation of triglyceride biosynthetic process [GO:0010867]; positive regulation of triglyceride catabolic process [GO:0010898]; receptor-mediated endocytosis [GO:0006898]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; regulation of cholesterol metabolic process [GO:0090181]; regulation of phosphatidylcholine catabolic process [GO:0010899]; regulation of protein metabolic process [GO:0051246]; response to caloric restriction [GO:0061771]; retinoid metabolic process [GO:0001523]	amyloid-beta binding [GO:0001540]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; lipoprotein particle binding [GO:0071813]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; molecular adaptor activity [GO:0060090]; protease binding [GO:0002020]; very-low-density lipoprotein particle receptor activity [GO:0030229]	apical part of cell [GO:0045177]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosome [GO:0005764]; PCSK9-LDLR complex [GO:1990666]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; signaling receptor complex [GO:0043235]; somatodendritic compartment [GO:0036477]; sorting endosome [GO:0097443]	GO:0001523; GO:0001540; GO:0001920; GO:0002020; GO:0005041; GO:0005509; GO:0005576; GO:0005764; GO:0005768; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0005901; GO:0005905; GO:0006629; GO:0006897; GO:0006898; GO:0006909; GO:0007616; GO:0008203; GO:0009897; GO:0009986; GO:0010628; GO:0010629; GO:0010867; GO:0010898; GO:0010899; GO:0010989; GO:0015914; GO:0016323; GO:0030169; GO:0030229; GO:0030299; GO:0030301; GO:0034381; GO:0034383; GO:0034384; GO:0036477; GO:0042157; GO:0042159; GO:0042632; GO:0042802; GO:0043235; GO:0045177; GO:0048844; GO:0050729; GO:0051246; GO:0051248; GO:0055038; GO:0060090; GO:0060840; GO:0061771; GO:0061889; GO:0070508; GO:0071398; GO:0071404; GO:0071813; GO:0090118; GO:0090181; GO:0097242; GO:0097443; GO:0150094; GO:1903979; GO:1905167; GO:1905907; GO:1990666
GN012804	GN012804.1	Q3UNX5	52.1	551	587	580	1.87e-206	591	ACSM3_MOUSE	Acyl-coenzyme A synthetase ACSM3, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 3) (Butyrate--CoA ligase 3) (Butyryl-coenzyme A synthetase 3) (Middle-chain acyl-CoA synthetase 3) (Propionate--CoA ligase) (EC 6.2.1.17) (Protein SA homolog)	Mus musculus (Mouse)	acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]	2-methylbutanoate-CoA ligase activity [GO:0043759]; fatty acid ligase activity [GO:0015645]; fatty-acyl-CoA synthase activity [GO:0004321]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; propionate CoA-transferase activity [GO:0018729]; propionate-CoA ligase activity [GO:0050218]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004321; GO:0005739; GO:0005759; GO:0006633; GO:0006637; GO:0015645; GO:0018729; GO:0031956; GO:0043759; GO:0050218
GN012807	GN012807.1	Q5F4A1	24.9	297	290	742	9.01e-11	65.9	G2E3_CHICK	G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase)	Gallus gallus (Chicken)	heterochromatin formation [GO:0031507]; pericentric heterochromatin formation [GO:0031508]; protein localization to chromosome [GO:0034502]; protein localization to condensed nuclear chromosome [GO:1903084]; protein ubiquitination [GO:0016567]	histone H3K14 ubiquitin ligase activity [GO:0140851]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	GO:0005634; GO:0005721; GO:0005730; GO:0005737; GO:0016567; GO:0031507; GO:0031508; GO:0034502; GO:0140851; GO:1903084
GN012808	GN012808.1	P15170	70.2	449	572	499	1.34e-219	620	ERF3A_HUMAN	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog)	Homo sapiens (Human)	G1/S transition of mitotic cell cycle [GO:0000082]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]; regulation of translational termination [GO:0006449]; translation [GO:0006412]; translational termination [GO:0006415]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; translation release factor activity [GO:0003747]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; translation release factor complex [GO:0018444]	GO:0000082; GO:0000184; GO:0003723; GO:0003747; GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0006412; GO:0006415; GO:0006449; GO:0006479; GO:0018444; GO:0022626
GN012809	GN012809.1	Q3SX41	61.4	228	424	432	4.43e-85	269	LC7L3_BOVIN	Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein)	Bos taurus (Bovine)	mRNA splice site recognition [GO:0006376]; RNA splicing [GO:0008380]	mRNA binding [GO:0003729]	nuclear speck [GO:0016607]; nucleus [GO:0005634]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]	GO:0003729; GO:0005634; GO:0005685; GO:0006376; GO:0008380; GO:0016607; GO:0071004
GN012815	GN012815.1	O88582	38.2	173	208	198	6.43e-31	115	SOCS2_RAT	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2)	Rattus norvegicus (Rat)	cellular response to hormone stimulus [GO:0032870]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway [GO:0060396]; intracellular signal transduction [GO:0035556]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; positive regulation of neuron differentiation [GO:0045666]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of multicellular organism growth [GO:0040014]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]	cytokine receptor binding [GO:0005126]; growth hormone receptor binding [GO:0005131]; insulin-like growth factor receptor binding [GO:0005159]; phosphorylation-dependent protein binding [GO:0140031]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]	GO:0005126; GO:0005131; GO:0005159; GO:0005737; GO:0007595; GO:0009968; GO:0016567; GO:0019221; GO:0031466; GO:0032355; GO:0032870; GO:0035556; GO:0040014; GO:0040015; GO:0043161; GO:0043434; GO:0045666; GO:0046426; GO:0060396; GO:0060400; GO:0060749; GO:0140031; GO:1990756
GN012818	GN012818.1	P50729	39.5	76	114	496	4.92e-10	58.5	RECS_BACSU	Probable ATP-dependent DNA helicase RecS (EC 5.6.2.4) (Probable DNA 3'-5' helicase RecS) (Recombination protein S)	Bacillus subtilis (strain 168)	DNA recombination [GO:0006310]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]	GO:0003676; GO:0005524; GO:0005694; GO:0005737; GO:0006310; GO:0016887; GO:0030894; GO:0043138; GO:0043590
GN012820	GN012820.1	O88582	37.6	173	180	198	2.11e-30	112	SOCS2_RAT	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2)	Rattus norvegicus (Rat)	cellular response to hormone stimulus [GO:0032870]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway [GO:0060396]; intracellular signal transduction [GO:0035556]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; positive regulation of neuron differentiation [GO:0045666]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of multicellular organism growth [GO:0040014]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]	cytokine receptor binding [GO:0005126]; growth hormone receptor binding [GO:0005131]; insulin-like growth factor receptor binding [GO:0005159]; phosphorylation-dependent protein binding [GO:0140031]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]	GO:0005126; GO:0005131; GO:0005159; GO:0005737; GO:0007595; GO:0009968; GO:0016567; GO:0019221; GO:0031466; GO:0032355; GO:0032870; GO:0035556; GO:0040014; GO:0040015; GO:0043161; GO:0043434; GO:0045666; GO:0046426; GO:0060396; GO:0060400; GO:0060749; GO:0140031; GO:1990756
GN012821	GN012821.1	O88582	38.2	173	208	198	2.29e-31	116	SOCS2_RAT	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2)	Rattus norvegicus (Rat)	cellular response to hormone stimulus [GO:0032870]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway [GO:0060396]; intracellular signal transduction [GO:0035556]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; positive regulation of neuron differentiation [GO:0045666]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of multicellular organism growth [GO:0040014]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]	cytokine receptor binding [GO:0005126]; growth hormone receptor binding [GO:0005131]; insulin-like growth factor receptor binding [GO:0005159]; phosphorylation-dependent protein binding [GO:0140031]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]	GO:0005126; GO:0005131; GO:0005159; GO:0005737; GO:0007595; GO:0009968; GO:0016567; GO:0019221; GO:0031466; GO:0032355; GO:0032870; GO:0035556; GO:0040014; GO:0040015; GO:0043161; GO:0043434; GO:0045666; GO:0046426; GO:0060396; GO:0060400; GO:0060749; GO:0140031; GO:1990756
GN012822	GN012822.1	O88582	38.2	173	208	198	2.29e-31	116	SOCS2_RAT	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2)	Rattus norvegicus (Rat)	cellular response to hormone stimulus [GO:0032870]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway [GO:0060396]; intracellular signal transduction [GO:0035556]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; positive regulation of neuron differentiation [GO:0045666]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of multicellular organism growth [GO:0040014]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]	cytokine receptor binding [GO:0005126]; growth hormone receptor binding [GO:0005131]; insulin-like growth factor receptor binding [GO:0005159]; phosphorylation-dependent protein binding [GO:0140031]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]	GO:0005126; GO:0005131; GO:0005159; GO:0005737; GO:0007595; GO:0009968; GO:0016567; GO:0019221; GO:0031466; GO:0032355; GO:0032870; GO:0035556; GO:0040014; GO:0040015; GO:0043161; GO:0043434; GO:0045666; GO:0046426; GO:0060396; GO:0060400; GO:0060749; GO:0140031; GO:1990756
GN012823	GN012823.1	O88582	37.6	173	212	198	4.04e-30	113	SOCS2_RAT	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2)	Rattus norvegicus (Rat)	cellular response to hormone stimulus [GO:0032870]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway [GO:0060396]; intracellular signal transduction [GO:0035556]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; positive regulation of neuron differentiation [GO:0045666]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of multicellular organism growth [GO:0040014]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]	cytokine receptor binding [GO:0005126]; growth hormone receptor binding [GO:0005131]; insulin-like growth factor receptor binding [GO:0005159]; phosphorylation-dependent protein binding [GO:0140031]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]	GO:0005126; GO:0005131; GO:0005159; GO:0005737; GO:0007595; GO:0009968; GO:0016567; GO:0019221; GO:0031466; GO:0032355; GO:0032870; GO:0035556; GO:0040014; GO:0040015; GO:0043161; GO:0043434; GO:0045666; GO:0046426; GO:0060396; GO:0060400; GO:0060749; GO:0140031; GO:1990756
GN012825	GN012825.1	O88582	37.6	173	208	198	5.05e-30	112	SOCS2_RAT	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2)	Rattus norvegicus (Rat)	cellular response to hormone stimulus [GO:0032870]; cytokine-mediated signaling pathway [GO:0019221]; growth hormone receptor signaling pathway [GO:0060396]; intracellular signal transduction [GO:0035556]; lactation [GO:0007595]; mammary gland alveolus development [GO:0060749]; negative regulation of growth hormone receptor signaling pathway [GO:0060400]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; positive regulation of neuron differentiation [GO:0045666]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of multicellular organism growth [GO:0040014]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]	cytokine receptor binding [GO:0005126]; growth hormone receptor binding [GO:0005131]; insulin-like growth factor receptor binding [GO:0005159]; phosphorylation-dependent protein binding [GO:0140031]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]	GO:0005126; GO:0005131; GO:0005159; GO:0005737; GO:0007595; GO:0009968; GO:0016567; GO:0019221; GO:0031466; GO:0032355; GO:0032870; GO:0035556; GO:0040014; GO:0040015; GO:0043161; GO:0043434; GO:0045666; GO:0046426; GO:0060396; GO:0060400; GO:0060749; GO:0140031; GO:1990756
GN012826	GN012826.1	Q59RQ0	49.4	79	251	906	1.42e-12	70.5	PIF1_CANAL	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)	double-strand break repair via break-induced replication [GO:0000727]; negative regulation of telomere maintenance via telomerase [GO:0032211]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; translesion synthesis [GO:0019985]	3'-5' exonuclease activity [GO:0008408]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; centromeric DNA binding [GO:0019237]; DNA helicase activity [GO:0003678]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex unwinding activity [GO:0160225]; single-stranded DNA binding [GO:0003697]; telomerase inhibitor activity [GO:0010521]; telomeric repeat DNA binding [GO:0042162]	mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; site of double-strand break [GO:0035861]	GO:0000722; GO:0000723; GO:0000727; GO:0003678; GO:0003697; GO:0005524; GO:0005739; GO:0008408; GO:0010521; GO:0016887; GO:0019237; GO:0019985; GO:0031966; GO:0032211; GO:0035861; GO:0042162; GO:0043139; GO:0043596; GO:0051880; GO:0071932; GO:0160225
GN012831	GN012831.1	Q15637	62.9	364	601	639	7.84e-143	431	SF01_HUMAN	Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162)	Homo sapiens (Human)	mRNA 3'-splice site recognition [GO:0000389]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of smooth muscle cell proliferation [GO:0048662]; spliceosomal complex assembly [GO:0000245]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701]	GO:0000245; GO:0000389; GO:0000398; GO:0003714; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005840; GO:0008270; GO:0016604; GO:0042802; GO:0045292; GO:0048662; GO:0089701
GN012832	GN012832.1	Q5ZL98	71.2	1337	1342	1390	0.0	1936	RPC1_CHICK	DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III subunit A)	Gallus gallus (Chicken)	tRNA transcription by RNA polymerase III [GO:0042797]	DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]	nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]	GO:0003677; GO:0003899; GO:0005654; GO:0005666; GO:0042797
GN012835	GN012835.1	Q8BHK3	25.8	325	606	478	1.55e-19	95.5	S36A2_MOUSE	Proton-coupled amino acid transporter 2 (Proton/amino acid transporter 2) (Solute carrier family 36 member 2) (Transmembrane domain rich protein 1) (Tramdorin-1)	Mus musculus (Mouse)	amino acid export across plasma membrane [GO:0032973]; glycine transport [GO:0015816]; L-alanine transport [GO:0015808]; positive regulation of glycine import across plasma membrane [GO:1900925]; proline transmembrane transport [GO:0035524]; proline transport [GO:0015824]; proton transmembrane transport [GO:1902600]; regulation of proline transport [GO:0070881]; regulation of proton transport [GO:0010155]	amino acid:proton symporter activity [GO:0005280]; gamma-aminobutyric acid:proton symporter activity [GO:0015495]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; proline:proton symporter activity [GO:0005297]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]	GO:0005280; GO:0005297; GO:0005789; GO:0005886; GO:0010155; GO:0015180; GO:0015187; GO:0015193; GO:0015495; GO:0015808; GO:0015816; GO:0015824; GO:0032973; GO:0035524; GO:0055038; GO:0070881; GO:1900925; GO:1902600
GN012836	GN012836.1	Q24JY3	29.8	121	200	197	4.17e-12	65.5	SPC24_BOVIN	Kinetochore protein Spc24	Bos taurus (Bovine)	chromosome segregation [GO:0007059]		Ndc80 complex [GO:0031262]; nucleus [GO:0005634]	GO:0005634; GO:0007059; GO:0031262
GN012837	GN012837.1	Q5ZL98	79.0	81	89	1390	1.19e-33	124	RPC1_CHICK	DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III subunit A)	Gallus gallus (Chicken)	tRNA transcription by RNA polymerase III [GO:0042797]	DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]	nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]	GO:0003677; GO:0003899; GO:0005654; GO:0005666; GO:0042797
GN012838	GN012838.1	A4IF62	100	26	67	1390	2.78e-09	54.3	RPC1_BOVIN	DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III subunit A)	Bos taurus (Bovine)	innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; tRNA transcription by RNA polymerase III [GO:0042797]	5'-3' RNA polymerase activity [GO:0034062]; DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]	GO:0003677; GO:0003899; GO:0005634; GO:0005654; GO:0005666; GO:0005829; GO:0032728; GO:0034062; GO:0042797; GO:0045087
GN012839	GN012839.1	A4IF62	70.9	671	657	1390	0.0	989	RPC1_BOVIN	DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III subunit A)	Bos taurus (Bovine)	innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; tRNA transcription by RNA polymerase III [GO:0042797]	5'-3' RNA polymerase activity [GO:0034062]; DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]	GO:0003677; GO:0003899; GO:0005634; GO:0005654; GO:0005666; GO:0005829; GO:0032728; GO:0034062; GO:0042797; GO:0045087
GN012840	GN012840.1	Q15637	62.9	364	601	639	7.84e-143	431	SF01_HUMAN	Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162)	Homo sapiens (Human)	mRNA 3'-splice site recognition [GO:0000389]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of smooth muscle cell proliferation [GO:0048662]; spliceosomal complex assembly [GO:0000245]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]; spliceosomal complex [GO:0005681]; U2AF complex [GO:0089701]	GO:0000245; GO:0000389; GO:0000398; GO:0003714; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005840; GO:0008270; GO:0016604; GO:0042802; GO:0045292; GO:0048662; GO:0089701
GN012844	GN012844.1	Q8N635	42.7	248	340	442	1.93e-62	208	MEIOB_HUMAN	Meiosis-specific with OB domain-containing protein (EC 3.1.-.-)	Homo sapiens (Human)	double-strand break repair via homologous recombination [GO:0000724]; female meiosis I [GO:0007144]; fertilization [GO:0009566]; homologous chromosome pairing at meiosis [GO:0007129]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; resolution of meiotic recombination intermediates [GO:0000712]	chromatin binding [GO:0003682]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]; single-stranded DNA binding [GO:0003697]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000712; GO:0000724; GO:0003682; GO:0003697; GO:0005634; GO:0005694; GO:0005737; GO:0007129; GO:0007140; GO:0007141; GO:0007144; GO:0008310; GO:0009566
GN012845	GN012845.1	Q4QRK0	65.6	384	356	386	1.00e-183	516	MAP11_DANRE	Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	intracellular zinc ion homeostasis [GO:0006882]; protein processing [GO:0016485]	initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]	cytosol [GO:0005829]	GO:0004239; GO:0005829; GO:0006882; GO:0016485; GO:0046872; GO:0070006
GN012846	GN012846.1	O60931	47.2	379	414	367	3.73e-113	338	CTNS_HUMAN	Cystinosin	Homo sapiens (Human)	amino acid metabolic process [GO:0006520]; ATP metabolic process [GO:0046034]; brain development [GO:0007420]; cognition [GO:0050890]; glutathione metabolic process [GO:0006749]; L-cystine transport [GO:0015811]; oligopeptide transmembrane transport [GO:0035672]; positive regulation of TORC1 signaling [GO:1904263]; regulation of melanin biosynthetic process [GO:0048021]; regulation of TORC1 signaling [GO:1903432]; transmembrane transport [GO:0055085]	L-cystine transmembrane transporter activity [GO:0015184]; solute:proton symporter activity [GO:0015295]	extracellular exosome [GO:0070062]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; plasma membrane [GO:0005886]	GO:0005764; GO:0005765; GO:0005770; GO:0005886; GO:0006520; GO:0006749; GO:0007420; GO:0015184; GO:0015295; GO:0015811; GO:0033162; GO:0035672; GO:0042470; GO:0046034; GO:0048021; GO:0050890; GO:0055085; GO:0070062; GO:1903432; GO:1904263
GN012848	GN012848.1	Q0VD59	32.1	137	239	289	7.44e-16	78.2	MARH8_BOVIN	E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING-type E3 ubiquitin transferase MARCHF8)	Bos taurus (Bovine)	antigen processing and presentation of peptide antigen via MHC class II [GO:0002495]; immune response [GO:0006955]; protein polyubiquitination [GO:0000209]	MHC protein binding [GO:0042287]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]	GO:0000139; GO:0000209; GO:0002495; GO:0004842; GO:0005737; GO:0005764; GO:0005765; GO:0005768; GO:0005789; GO:0006955; GO:0008270; GO:0030659; GO:0031901; GO:0031902; GO:0042287; GO:0061630
GN012849	GN012849.1	P28288	71.0	662	658	659	0.0	922	ABCD3_HUMAN	ATP-binding cassette sub-family D member 3 (EC 3.1.2.-) (EC 7.6.2.-) (70 kDa peroxisomal membrane protein) (PMP70)	Homo sapiens (Human)	bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; fatty acid beta-oxidation [GO:0006635]; fatty acid biosynthetic process [GO:0006633]; long-chain fatty acid import into peroxisome [GO:0015910]; peroxisome organization [GO:0007031]; phytanic acid metabolic process [GO:1903512]; response to xenobiotic stimulus [GO:0009410]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; fatty acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; protein homodimerization activity [GO:0042803]; very long-chain fatty acyl-CoA hydrolase activity [GO:0052817]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0000038; GO:0005324; GO:0005524; GO:0005739; GO:0005777; GO:0005778; GO:0005782; GO:0005829; GO:0006633; GO:0006635; GO:0006699; GO:0007031; GO:0009410; GO:0015721; GO:0015910; GO:0016020; GO:0016887; GO:0042626; GO:0042760; GO:0042803; GO:0047617; GO:0052817; GO:0140359; GO:1903512
GN012856	GN012856.1	Q0E908	25.6	445	1436	818	3.55e-33	142	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN012858	GN012858.1	Q0E908	24.3	334	638	818	2.11e-17	90.1	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN012859	GN012859.1	Q0E908	25.6	469	1304	818	1.12e-31	137	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN012866	GN012866.1	Q3T0D7	42.1	190	187	198	1.09e-51	167	SAR1A_BOVIN	Small COPII coat GTPase SAR1A (EC 3.6.5.2)	Bos taurus (Bovine)	cellular response to leucine starvation [GO:1990253]; COPII vesicle coating [GO:0048208]; COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; negative regulation of TORC1 signaling [GO:1904262]; regulation of COPII vesicle coating [GO:0003400]; vesicle organization [GO:0016050]	amino acid sensor activity [GO:0140785]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; lysosomal membrane [GO:0005765]	GO:0003400; GO:0003924; GO:0003925; GO:0005525; GO:0005765; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0016050; GO:0030127; GO:0032580; GO:0048208; GO:0061024; GO:0070971; GO:0090110; GO:0140785; GO:1904262; GO:1990253
GN012871	GN012871.1	Q8NBH2	26.1	536	562	661	1.12e-48	182	KY_HUMAN	Kyphoscoliosis peptidase (EC 3.4.-.-)	Homo sapiens (Human)	muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]	GO:0005737; GO:0005856; GO:0007517; GO:0007528; GO:0030018
GN012874	GN012874.1	A4QNP7	38.6	370	359	437	8.55e-52	181	DMTA2_XENTR	Doublesex- and mab-3-related transcription factor A2 (Doublesex- and mab-3-related transcription factor 5)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	regulation of transcription by RNA polymerase II [GO:0006357]; sex differentiation [GO:0007548]; system development [GO:0048731]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0007548; GO:0048731
GN012875	GN012875.1	P80363	40.5	185	205	202	2.05e-44	149	CCB23_FAXLI	Crustacean calcium-binding protein 23 (CCBP-23)	Faxonius limosus (Spinycheek crayfish) (Orconectes limosus)		calcium ion binding [GO:0005509]		GO:0005509
GN012878	GN012878.1	Q16960	75.4	528	604	597	3.55e-300	830	DYI3_HELCR	Dynein intermediate chain 3, ciliary	Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina)	cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]	dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]	outer dynein arm [GO:0036157]	GO:0003341; GO:0036157; GO:0036158; GO:0045503; GO:0045504
GN012879	GN012879.1	O43299	31.4	803	778	807	8.65e-113	364	AP5Z1_HUMAN	AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5)	Homo sapiens (Human)	double-strand break repair via homologous recombination [GO:0000724]; endosomal transport [GO:0016197]; lysosome organization [GO:0007040]; vesicle-mediated transport [GO:0016192]		AP-5 adaptor complex [GO:0044599]; AP-type membrane coat adaptor complex [GO:0030119]; cytoplasm [GO:0005737]; late endosome [GO:0005770]; lysosome [GO:0005764]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000724; GO:0005634; GO:0005654; GO:0005737; GO:0005764; GO:0005770; GO:0007040; GO:0016192; GO:0016197; GO:0016607; GO:0030119; GO:0044599
GN012880	GN012880.1	Q8R0H9	41.3	640	1788	635	5.53e-117	388	GGA1_MOUSE	ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)	Mus musculus (Mouse)	Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein localization [GO:0008104]; intracellular protein transport [GO:0006886]; positive regulation of protein catabolic process [GO:0045732]; protein localization to cell surface [GO:0034394]; protein localization to ciliary membrane [GO:1903441]; retrograde transport, endosome to Golgi [GO:0042147]	phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; trans-Golgi network [GO:0005802]	GO:0005654; GO:0005769; GO:0005794; GO:0005802; GO:0005829; GO:0006886; GO:0006893; GO:0008104; GO:0010008; GO:0031267; GO:0031901; GO:0032991; GO:0034394; GO:0035091; GO:0042147; GO:0043001; GO:0043130; GO:0045732; GO:1903441
GN012881	GN012881.1	A7T1N0	30.9	1204	1572	1551	1.37e-164	542	TMP2L_NEMVE	Transient receptor potential cation channel subfamily M member-like 2 (nvTRPM2)	Nematostella vectensis (Starlet sea anemone)	calcium ion transmembrane transport [GO:0070588]; sodium ion transmembrane transport [GO:0035725]	ADP-ribose diphosphatase activity [GO:0047631]; ligand-gated calcium channel activity [GO:0099604]; ligand-gated sodium channel activity [GO:0015280]	plasma membrane [GO:0005886]	GO:0005886; GO:0015280; GO:0035725; GO:0047631; GO:0070588; GO:0099604
GN012882	GN012882.1	Q08CM4	43.7	609	764	771	1.35e-127	401	LIN54_DANRE	Protein lin-54 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of DNA-templated transcription [GO:0006355]		nucleus [GO:0005634]	GO:0005634; GO:0006355
GN012883	GN012883.1	O88544	80.4	363	367	406	2.25e-204	570	CSN4_MOUSE	COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)	Mus musculus (Mouse)	protein deneddylation [GO:0000338]		cell junction [GO:0030054]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021]	GO:0000338; GO:0005634; GO:0005737; GO:0008021; GO:0008180; GO:0016607; GO:0030054
GN012884	GN012884.1	P43021	43.0	100	331	354	1.83e-24	105	NODAL_MOUSE	Nodal	Mus musculus (Mouse)	anatomical structure formation involved in morphogenesis [GO:0048646]; anterior/posterior axis specification [GO:0009948]; anterior/posterior pattern specification [GO:0009952]; apoptotic signaling pathway [GO:0097190]; axial mesodermal cell fate specification [GO:0048327]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cell migration [GO:0016477]; cell migration involved in gastrulation [GO:0042074]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; determination of left/right symmetry [GO:0007368]; digestive system development [GO:0055123]; digestive tract morphogenesis [GO:0048546]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic heart tube development [GO:0035050]; embryonic pattern specification [GO:0009880]; embryonic placenta development [GO:0001892]; embryonic process involved in female pregnancy [GO:0060136]; endoderm development [GO:0007492]; endodermal cell differentiation [GO:0035987]; epiblast cell-extraembryonic ectoderm cell signaling [GO:0060802]; floor plate morphogenesis [GO:0033505]; formation of anatomical boundary [GO:0048859]; gastrulation [GO:0007369]; gastrulation with mouth forming second [GO:0001702]; heart development [GO:0007507]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; inhibition of neuroepithelial cell differentiation [GO:0002085]; left lung morphogenesis [GO:0060460]; liver development [GO:0001889]; lung development [GO:0030324]; maternal placenta development [GO:0001893]; maternal process involved in parturition [GO:0060137]; mesendoderm development [GO:0048382]; mesoderm formation [GO:0001707]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell development [GO:0010721]; negative regulation of cell differentiation [GO:0045596]; negative regulation of chorionic trophoblast cell proliferation [GO:1901383]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of trophoblast cell migration [GO:1901164]; nervous system development [GO:0007399]; neural fold formation [GO:0001842]; nodal signaling pathway [GO:0038092]; placenta development [GO:0001890]; polarity specification of proximal/distal axis [GO:0010085]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; primitive streak formation [GO:0090009]; regulation of gastrulation [GO:0010470]; regulation of signal transduction [GO:0009966]; stem cell population maintenance [GO:0019827]; tissue morphogenesis [GO:0048729]; transforming growth factor beta receptor signaling pathway [GO:0007179]; trophectodermal cell differentiation [GO:0001829]; trophectodermal cellular morphogenesis [GO:0001831]; vasculature development [GO:0001944]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; receptor ligand activity [GO:0048018]; type I activin receptor binding [GO:0070698]	extracellular region [GO:0005576]	GO:0000122; GO:0001701; GO:0001702; GO:0001707; GO:0001829; GO:0001831; GO:0001842; GO:0001889; GO:0001890; GO:0001892; GO:0001893; GO:0001944; GO:0001947; GO:0002085; GO:0003140; GO:0005125; GO:0005576; GO:0007179; GO:0007368; GO:0007369; GO:0007399; GO:0007420; GO:0007492; GO:0007507; GO:0008083; GO:0008284; GO:0009880; GO:0009948; GO:0009952; GO:0009966; GO:0010085; GO:0010470; GO:0010575; GO:0010721; GO:0016477; GO:0019827; GO:0022409; GO:0030154; GO:0030324; GO:0033505; GO:0035050; GO:0035987; GO:0038092; GO:0042074; GO:0045165; GO:0045596; GO:0045766; GO:0045944; GO:0048018; GO:0048327; GO:0048382; GO:0048546; GO:0048646; GO:0048701; GO:0048729; GO:0048859; GO:0050679; GO:0055123; GO:0060136; GO:0060137; GO:0060391; GO:0060460; GO:0060766; GO:0060802; GO:0070374; GO:0070698; GO:0090009; GO:0097190; GO:1901164; GO:1901383
GN012885	GN012885.1	Q6DFZ1	54.8	1799	1911	1861	0.0	1723	GBF1_MOUSE	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1)	Mus musculus (Mouse)	cell activation involved in immune response [GO:0002263]; cellular response to virus [GO:0098586]; COPI coating of Golgi vesicle [GO:0048205]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; establishment of monopolar cell polarity [GO:0061162]; Golgi disassembly [GO:0090166]; Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; neutrophil chemotaxis [GO:0030593]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to endoplasmic reticulum tubular network [GO:1903420]; protein localization to Golgi apparatus [GO:0034067]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of ARF protein signal transduction [GO:0032012]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization to cell surface [GO:2000008]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]	cell leading edge [GO:0031252]; cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; peroxisome [GO:0005777]; trans-Golgi network [GO:0005802]	GO:0000137; GO:0000139; GO:0002263; GO:0005085; GO:0005547; GO:0005737; GO:0005777; GO:0005788; GO:0005793; GO:0005794; GO:0005795; GO:0005801; GO:0005802; GO:0005811; GO:0005829; GO:0006890; GO:0006895; GO:0007030; GO:0007346; GO:0030593; GO:0031252; GO:0032012; GO:0034067; GO:0042147; GO:0048205; GO:0061162; GO:0070973; GO:0080025; GO:0090166; GO:0097111; GO:0098586; GO:1903409; GO:1903420; GO:2000008
GN012886	GN012886.1	Q08DX0	46.0	313	616	817	6.50e-80	272	SNX29_BOVIN	Sorting nexin-29	Bos taurus (Bovine)		phosphatidylinositol binding [GO:0035091]		GO:0035091
GN012887	GN012887.1	O61231	74.2	128	129	218	2.00e-65	200	RL10_DROME	Large ribosomal subunit protein uL16 (60S ribosomal protein L10) (QM protein homolog) (dQM)	Drosophila melanogaster (Fruit fly)	cytoplasmic translation [GO:0002181]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; neuronal cell body [GO:0043025]	GO:0002181; GO:0003735; GO:0005737; GO:0006412; GO:0022625; GO:0022626; GO:0043025
GN012890	GN012890.1	Q27128	76.4	601	610	610	0.0	952	PAPSS_URECA	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase (PAPS synthase) (PAPS synthetase) (PAPSS) (Sulfurylase kinase) (SK) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]	Urechis caupo (Innkeeper worm) (Spoonworm)	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; sulfate assimilation [GO:0000103]	adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; sulfate adenylyltransferase (ATP) activity [GO:0004781]		GO:0000103; GO:0004020; GO:0004781; GO:0005524; GO:0016779; GO:0050428
GN012891	GN012891.1	F1NPQ2	34.7	392	464	448	3.38e-68	227	MINP1_CHICK	Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Band 17) (Histidine phosphatase of the endoplasmic reticulum 1) (HiPER1)	Gallus gallus (Chicken)	intracellular monoatomic cation homeostasis [GO:0030003]	acid phosphatase activity [GO:0003993]; bisphosphoglycerate 3-phosphatase activity [GO:0034417]; inositol bisphosphate phosphatase activity [GO:0016312]; inositol hexakisphosphate 3-phosphatase activity [GO:0016158]; inositol hexakisphosphate 4-phosphatase activity [GO:0008707]; inositol hexakisphosphate phosphatase activity [GO:0004446]; inositol pentakisphosphate phosphatase activity [GO:0052827]; inositol phosphate phosphatase activity [GO:0052745]; inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity [GO:0030351]; inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity [GO:0030352]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0003993; GO:0004446; GO:0005576; GO:0005788; GO:0005886; GO:0008707; GO:0016158; GO:0016312; GO:0030003; GO:0030351; GO:0030352; GO:0034417; GO:0046030; GO:0052745; GO:0052827
GN012892	GN012892.1	F1NPQ2	29.9	137	148	448	6.54e-19	85.1	MINP1_CHICK	Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Band 17) (Histidine phosphatase of the endoplasmic reticulum 1) (HiPER1)	Gallus gallus (Chicken)	intracellular monoatomic cation homeostasis [GO:0030003]	acid phosphatase activity [GO:0003993]; bisphosphoglycerate 3-phosphatase activity [GO:0034417]; inositol bisphosphate phosphatase activity [GO:0016312]; inositol hexakisphosphate 3-phosphatase activity [GO:0016158]; inositol hexakisphosphate 4-phosphatase activity [GO:0008707]; inositol hexakisphosphate phosphatase activity [GO:0004446]; inositol pentakisphosphate phosphatase activity [GO:0052827]; inositol phosphate phosphatase activity [GO:0052745]; inositol trisphosphate phosphatase activity [GO:0046030]; inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity [GO:0030351]; inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity [GO:0030352]	endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0003993; GO:0004446; GO:0005576; GO:0005788; GO:0005886; GO:0008707; GO:0016158; GO:0016312; GO:0030003; GO:0030351; GO:0030352; GO:0034417; GO:0046030; GO:0052745; GO:0052827
GN012895	GN012895.1	Q9Y0A7	71.4	63	185	198	5.69e-21	88.6	AMOS_DROME	Basic helix-loop-helix transcription factor amos (Absent MD neurons and olfactory sensilla protein) (Amos protein) (Reduced olfactory organs protein) (Rough eye protein)	Drosophila melanogaster (Fruit fly)	axon development [GO:0061564]; dendrite morphogenesis [GO:0048813]; neuron fate commitment [GO:0048663]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ boundary specification [GO:0008052]; sensory organ development [GO:0007423]; sensory organ precursor cell fate determination [GO:0016360]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein heterodimerization activity [GO:0046982]	nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0007423; GO:0008052; GO:0016360; GO:0045944; GO:0046982; GO:0048663; GO:0048813; GO:0061564; GO:0070888
GN012900	GN012900.1	Q8VDS3	52.3	65	295	158	7.33e-16	76.6	CBX7_MOUSE	Chromobox protein homolog 7	Mus musculus (Mouse)	negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; sebaceous gland development [GO:0048733]	chromatin binding [GO:0003682]; histone H3K9me2/3 reader activity [GO:0062072]; single-stranded RNA binding [GO:0003727]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytosol [GO:0005829]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]	GO:0000122; GO:0000785; GO:0000792; GO:0003682; GO:0003727; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0031519; GO:0032968; GO:0035102; GO:0048733; GO:0062072
GN012901	GN012901.1	P08684	36.6	484	492	503	3.49e-94	297	CP3A4_HUMAN	Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55)	Homo sapiens (Human)	aflatoxin metabolic process [GO:0046222]; alkaloid catabolic process [GO:0009822]; cholesterol metabolic process [GO:0008203]; estrogen metabolic process [GO:0008210]; lipid hydroxylation [GO:0002933]; lipid metabolic process [GO:0006629]; long-chain fatty acid biosynthetic process [GO:0042759]; monoterpenoid metabolic process [GO:0016098]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid catabolic process [GO:0006706]; steroid metabolic process [GO:0008202]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	1,8-cineole 2-exo-monooxygenase activity [GO:0102320]; 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity [GO:0062181]; anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; arachidonate 14,15-epoxygenase activity [GO:0008404]; caffeine oxidase activity [GO:0034875]; enzyme binding [GO:0019899]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; oxygen binding [GO:0019825]; quinine 3-monooxygenase activity [GO:0050591]; retinoic acid 4-hydroxylase activity [GO:0008401]; steroid binding [GO:0005496]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]; vitamin D 24-hydroxylase activity [GO:0070576]; vitamin D 25-hydroxylase activity [GO:0030343]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	GO:0002933; GO:0004497; GO:0005496; GO:0005506; GO:0005737; GO:0005789; GO:0006629; GO:0006706; GO:0006805; GO:0008202; GO:0008203; GO:0008210; GO:0008395; GO:0008401; GO:0008404; GO:0009822; GO:0016098; GO:0016491; GO:0016712; GO:0019825; GO:0019899; GO:0020037; GO:0030343; GO:0034875; GO:0042178; GO:0042359; GO:0042369; GO:0042572; GO:0042573; GO:0042759; GO:0043231; GO:0046222; GO:0050591; GO:0050649; GO:0062181; GO:0062187; GO:0062188; GO:0062189; GO:0070576; GO:0070989; GO:0101020; GO:0101021; GO:0102320
GN012905	GN012905.1	Q559R0	50.0	50	66	188	4.20e-10	55.5	SAR1A_DICDI	Small COPII coat GTPase SAR1A (EC 3.6.5.2)	Dictyostelium discoideum (Social amoeba)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; regulation of COPII vesicle coating [GO:0003400]; vesicle organization [GO:0016050]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; phagocytic vesicle [GO:0045335]	GO:0003400; GO:0003924; GO:0003925; GO:0005525; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0016050; GO:0030127; GO:0032580; GO:0045335; GO:0061024; GO:0070971
GN012907	GN012907.1	Q14831	27.6	453	523	915	6.34e-46	176	GRM7_HUMAN	Metabotropic glutamate receptor 7 (mGluR7)	Homo sapiens (Human)	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; axon development [GO:0061564]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of glutamate secretion [GO:0014050]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of sound [GO:0007605]	adenylate cyclase inhibitor activity [GO:0010855]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; glutamate binding [GO:0016595]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]; PDZ domain binding [GO:0030165]; protein dimerization activity [GO:0046983]; serine binding [GO:0070905]; voltage-gated calcium channel activity [GO:0005245]	asymmetric synapse [GO:0032279]; axon [GO:0030424]; cell cortex [GO:0005938]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; signaling receptor complex [GO:0043235]	GO:0001642; GO:0005245; GO:0005246; GO:0005509; GO:0005886; GO:0005938; GO:0007193; GO:0007196; GO:0007216; GO:0007268; GO:0007605; GO:0008066; GO:0010855; GO:0014050; GO:0016020; GO:0016595; GO:0030165; GO:0030424; GO:0030425; GO:0032279; GO:0042734; GO:0043198; GO:0043235; GO:0045211; GO:0046983; GO:0048786; GO:0051966; GO:0061564; GO:0070905; GO:0098978; GO:0099171
GN012908	GN012908.1	P31423	24.7	352	396	912	1.32e-15	82.4	GRM4_RAT	Metabotropic glutamate receptor 4 (mGluR4)	Rattus norvegicus (Rat)	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gamma-aminobutyric acid secretion [GO:0014051]; learning [GO:0007612]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of synaptic transmission [GO:0050805]; neuron projection development [GO:0031175]; positive regulation of MAPK cascade [GO:0043410]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of neuron apoptotic process [GO:0043523]; regulation of synaptic transmission, glutamatergic [GO:0051966]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]	cerebellar granule cell to Purkinje cell synapse [GO:0150048]; cytoplasmic vesicle [GO:0031410]; dendritic shaft [GO:0043198]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; terminal bouton [GO:0043195]	GO:0001640; GO:0004930; GO:0005516; GO:0005886; GO:0007196; GO:0007216; GO:0007268; GO:0007612; GO:0008066; GO:0008285; GO:0014051; GO:0031175; GO:0031410; GO:0035249; GO:0043005; GO:0043066; GO:0043195; GO:0043198; GO:0043410; GO:0043523; GO:0048306; GO:0048787; GO:0050805; GO:0051932; GO:0051966; GO:0098688; GO:0098978; GO:0099171; GO:0150048
GN012909	GN012909.1	P91550	65.3	75	253	1104	1.24e-24	105	GCY15_CAEEL	Receptor-type guanylate cyclase gcy-15 (EC 4.6.1.2)	Caenorhabditis elegans	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	plasma membrane [GO:0005886]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0006182; GO:0007168; GO:0035556
GN012910	GN012910.1	Q3UVX5	32.3	248	545	1203	1.30e-26	118	GRM5_MOUSE	Metabotropic glutamate receptor 5 (mGluR5)	Mus musculus (Mouse)	associative learning [GO:0008306]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; conditioned place preference [GO:1990708]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of excitatory postsynaptic potential [GO:0090394]; operant conditioning [GO:0035106]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cellular response to hypoxia [GO:1900039]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of sensory perception of pain [GO:1904058]; protein localization to nuclear inner membrane [GO:0036228]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of long-term synaptic depression [GO:1900452]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of hot stimulus [GO:0062036]; synapse organization [GO:0050808]; temperature homeostasis [GO:0001659]	A2A adenosine receptor binding [GO:0031687]; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; PLC activating G protein-coupled glutamate receptor activity [GO:0001639]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase binding [GO:1990782]	astrocyte projection [GO:0097449]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0001639; GO:0001640; GO:0001659; GO:0002029; GO:0004930; GO:0005637; GO:0005737; GO:0005886; GO:0006355; GO:0006468; GO:0007204; GO:0007206; GO:0007216; GO:0007268; GO:0007611; GO:0007612; GO:0007626; GO:0008066; GO:0008306; GO:0030296; GO:0030425; GO:0031687; GO:0033603; GO:0035106; GO:0036228; GO:0042802; GO:0043005; GO:0043025; GO:0043197; GO:0043198; GO:0043410; GO:0044309; GO:0045211; GO:0048169; GO:0048170; GO:0050804; GO:0050808; GO:0050850; GO:0050890; GO:0051966; GO:0061002; GO:0062036; GO:0090394; GO:0097449; GO:0098685; GO:0098839; GO:0098978; GO:0099530; GO:1900039; GO:1900452; GO:1904058; GO:1904646; GO:1990708; GO:1990782; GO:2000179
GN012911	GN012911.1	Q13255	31.6	187	188	1194	6.45e-13	69.7	GRM1_HUMAN	Metabotropic glutamate receptor 1 (mGluR1)	Homo sapiens (Human)	chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; G protein-coupled receptor signaling pathway [GO:0007186]; locomotory behavior [GO:0007626]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of MAPK cascade [GO:0043410]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]; synaptic signaling via neuropeptide [GO:0099538]	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled neurotransmitter receptor activity [GO:0099528]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]	dendriole [GO:0044293]; G protein-coupled receptor dimeric complex [GO:0038037]; G protein-coupled receptor homodimeric complex [GO:0038038]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0001640; GO:0004930; GO:0005634; GO:0005886; GO:0007186; GO:0007200; GO:0007206; GO:0007216; GO:0007268; GO:0007626; GO:0008066; GO:0019233; GO:0038037; GO:0038038; GO:0043410; GO:0044293; GO:0045211; GO:0051930; GO:0051966; GO:0098685; GO:0098839; GO:0098978; GO:0099528; GO:0099530; GO:0099538
GN012914	GN012914.1	Q99447	60.2	352	335	389	2.97e-147	423	PCY2_HUMAN	Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase)	Homo sapiens (Human)	phosphatidylethanolamine biosynthetic process [GO:0006646]; phospholipid biosynthetic process [GO:0008654]	ethanolamine-phosphate cytidylyltransferase activity [GO:0004306]	endoplasmic reticulum membrane [GO:0005789]	GO:0004306; GO:0005789; GO:0006646; GO:0008654
GN012915	GN012915.1	Q7TN88	25.9	1137	4259	2461	1.69e-87	325	PK1L2_MOUSE	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Mus musculus (Mouse)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]	membrane [GO:0016020]	GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN012918	GN012918.1	P28646	41.3	317	418	391	4.73e-71	231	SSR1_RAT	Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R) (SRIF-2)	Rattus norvegicus (Rat)	cellular response to estradiol stimulus [GO:0071392]; cellular response to leukemia inhibitory factor [GO:1990830]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; glutamate receptor signaling pathway [GO:0007215]; negative regulation of growth hormone secretion [GO:0060125]; neuropeptide signaling pathway [GO:0007218]; response to starvation [GO:0042594]; spermatogenesis [GO:0007283]; T cell differentiation [GO:0030217]	neuropeptide binding [GO:0042923]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; somatostatin receptor activity [GO:0004994]	cytoplasm [GO:0005737]; G protein-coupled receptor heterodimeric complex [GO:0038039]; G protein-coupled receptor homodimeric complex [GO:0038038]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	GO:0004994; GO:0005737; GO:0005886; GO:0007186; GO:0007215; GO:0007218; GO:0007283; GO:0016020; GO:0021549; GO:0030217; GO:0030900; GO:0038038; GO:0038039; GO:0042594; GO:0042803; GO:0042923; GO:0043005; GO:0046982; GO:0060125; GO:0071392; GO:1990830
GN012920	GN012920.1	P35408	34.3	344	510	488	2.41e-56	198	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of stress fiber assembly [GO:0051492]; response to mechanical stimulus [GO:0009612]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0009612; GO:0016020; GO:0033624; GO:0034695; GO:0042093; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070371; GO:0071260; GO:0071380; GO:2000420
GN012923	GN012923.1	O89035	66.4	122	143	286	3.67e-54	174	DIC_RAT	Mitochondrial dicarboxylate carrier (DIC) (Solute carrier family 25 member 10)	Rattus norvegicus (Rat)	glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; malate transmembrane transport [GO:0071423]; malate transport [GO:0015743]; oxaloacetate transport [GO:0015729]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; succinate transmembrane transport [GO:0071422]; sulfate transmembrane transport [GO:1902358]; thiosulfate transport [GO:0015709]	dicarboxylic acid transmembrane transporter activity [GO:0005310]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; phosphate transmembrane transporter activity [GO:0005315]; secondary active transmembrane transporter activity [GO:0015291]; succinate transmembrane transporter activity [GO:0015141]; sulfate transmembrane transporter activity [GO:0015116]; thiosulfate transmembrane transporter activity [GO:0015117]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005310; GO:0005315; GO:0005739; GO:0005743; GO:0006817; GO:0015116; GO:0015117; GO:0015131; GO:0015140; GO:0015141; GO:0015291; GO:0015709; GO:0015729; GO:0015743; GO:0035435; GO:0046166; GO:0071422; GO:0071423; GO:1902358
GN012925	GN012925.1	A6H603	28.8	924	1066	1563	9.74e-89	317	NWD1_MOUSE	NACHT domain- and WD repeat-containing protein 1	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; positive regulation of gene expression [GO:0010628]		cytosol [GO:0005829]; nucleolus [GO:0005730]	GO:0005730; GO:0005829; GO:0010628; GO:0035556
GN012926	GN012926.1	P91943	46.1	434	524	751	1.36e-77	261	PANG1_DROME	Protein pangolin, isoforms A/H/I/S (dTCF)	Drosophila melanogaster (Fruit fly)	embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; imaginal disc-derived wing morphogenesis [GO:0007476]; mesodermal cell fate determination [GO:0007500]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell proliferation [GO:0072091]; salivary gland morphogenesis [GO:0007435]; spiracle morphogenesis, open tracheal system [GO:0035277]; Wnt signaling pathway [GO:0016055]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; kinase binding [GO:0019900]; transcription corepressor binding [GO:0001222]	nucleoplasm [GO:0005654]; transcription regulator complex [GO:0005667]	GO:0000981; GO:0001222; GO:0001228; GO:0005654; GO:0005667; GO:0006355; GO:0007435; GO:0007476; GO:0007500; GO:0007507; GO:0009880; GO:0010628; GO:0016055; GO:0019900; GO:0035277; GO:0045892; GO:0045893; GO:0045944; GO:0072091; GO:0140297
GN012927	GN012927.1	Q6BWA5	62.5	288	338	287	9.30e-130	375	IPYR_DEBHA	Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)	phosphate-containing compound metabolic process [GO:0006796]	inorganic diphosphate phosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]	cytoplasm [GO:0005737]	GO:0000287; GO:0004427; GO:0005737; GO:0006796
GN012930	GN012930.1	O60290	25.6	312	327	1169	2.50e-15	80.5	ZN862_HUMAN	Zinc finger protein 862	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	protein dimerization activity [GO:0046983]	nucleus [GO:0005634]	GO:0005634; GO:0006355; GO:0046983
GN012933	GN012933.1	Q8SWR3	43.8	297	318	435	2.67e-64	212	SPR_DROME	Sex peptide receptor	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of egg-laying behavior [GO:0046662]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008528; GO:0045434; GO:0046662
GN012935	GN012935.1	Q8IN35	32.5	249	265	758	1.01e-27	115	SIFAR_DROME	Neuropeptide SIFamide receptor	Drosophila melanogaster (Fruit fly)	cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; male mating behavior [GO:0060179]; mating behavior, sex discrimination [GO:0048047]; neuropeptide signaling pathway [GO:0007218]	G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0007218; GO:0008188; GO:0016020; GO:0032870; GO:0048047; GO:0060179
GN012938	GN012938.1	Q6DJP7	55.1	254	330	269	7.80e-50	170	CPSF4_XENLA	Cleavage and polyadenylation specificity factor subunit 4	Xenopus laevis (African clawed frog)		RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]	GO:0003723; GO:0005847; GO:0008270
GN012942	GN012942.1	Q9CPQ3	50.5	91	149	142	1.99e-21	87.0	TOM22_MOUSE	Mitochondrial import receptor subunit TOM22 homolog (Translocase of outer membrane 22 kDa subunit homolog)	Mus musculus (Mouse)	positive regulation of apoptotic process [GO:0043065]; protein import into mitochondrial matrix [GO:0030150]; protein insertion into mitochondrial membrane [GO:0051204]	mitochondrion targeting sequence binding [GO:0030943]; transmembrane protein transporter activity [GO:0008320]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]	GO:0005739; GO:0005741; GO:0005742; GO:0005743; GO:0008320; GO:0016020; GO:0030150; GO:0030943; GO:0043065; GO:0051204
GN012943	GN012943.1	Q58CS8	48.2	228	282	306	1.23e-63	205	GNPTG_BOVIN	N-acetylglucosamine-1-phosphotransferase subunit gamma (GlcNAc-1-phosphotransferase subunit gamma) (UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma)	Bos taurus (Bovine)	carbohydrate phosphorylation [GO:0046835]	protein homodimerization activity [GO:0042803]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]	GO:0005576; GO:0005794; GO:0042803; GO:0046835
GN012944	GN012944.1	Q5HZH2	56.5	216	306	323	2.94e-78	244	TSR3_MOUSE	18S rRNA aminocarboxypropyltransferase (EC 2.5.1.157) (20S S rRNA accumulation protein 3 homolog)	Mus musculus (Mouse)	enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; maturation of SSU-rRNA [GO:0030490]	rRNA small subunit aminocarboxypropyltransferase activity [GO:0106388]; S-adenosyl-L-methionine binding [GO:1904047]; transferase activity [GO:0016740]	cytoplasm [GO:0005737]	GO:0000455; GO:0005737; GO:0016740; GO:0030490; GO:0106388; GO:1904047
GN012945	GN012945.1	O88496	55.1	595	741	758	3.57e-235	677	VKGC_RAT	Vitamin K-dependent gamma-carboxylase (VKGC) (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase)	Rattus norvegicus (Rat)	lung growth [GO:0060437]; negative regulation of bone development [GO:1903011]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of testosterone biosynthetic process [GO:2000225]; peptidyl-glutamic acid carboxylation [GO:0017187]; protein maturation [GO:0051604]; response to dexamethasone [GO:0071548]; response to manganese ion [GO:0010042]; response to oxygen levels [GO:0070482]; response to parathyroid hormone [GO:0071107]; response to Thyroglobulin triiodothyronine [GO:1904016]; response to vitamin D [GO:0033280]; response to vitamin K [GO:0032571]; vitamin K metabolic process [GO:0042373]	gamma-glutamyl carboxylase activity [GO:0008488]; peptide binding [GO:0042277]; vitamin binding [GO:0019842]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]	GO:0005788; GO:0005789; GO:0008488; GO:0010042; GO:0017187; GO:0019842; GO:0032571; GO:0033280; GO:0042277; GO:0042373; GO:0046929; GO:0051604; GO:0060437; GO:0070482; GO:0071107; GO:0071548; GO:1903011; GO:1904016; GO:2000225
GN012946	GN012946.1	P24733	78.4	899	1965	1938	0.0	1382	MYS_ARGIR	Myosin heavy chain, striated muscle	Argopecten irradians (Bay scallop) (Aequipecten irradians)	locomotion [GO:0040011]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; myosin filament organization [GO:0031033]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; structural constituent of muscle [GO:0008307]	myofibril [GO:0030016]; myosin filament [GO:0032982]; myosin II complex [GO:0016460]	GO:0000146; GO:0005524; GO:0006936; GO:0008307; GO:0016460; GO:0030016; GO:0030239; GO:0031033; GO:0032982; GO:0040011; GO:0051015
GN012947	GN012947.1	O95487	60.3	764	1384	1268	8.14e-318	931	SC24B_HUMAN	Protein transport protein Sec24B (SEC24-related protein B)	Homo sapiens (Human)	COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]	SNARE binding [GO:0000149]; zinc ion binding [GO:0008270]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]	GO:0000149; GO:0005783; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0008270; GO:0012507; GO:0030127; GO:0070863; GO:0090110; GO:1902953
GN012952	GN012952.1	Q9W5U2	34.7	1022	1090	2286	2.56e-176	573	CHI10_DROME	Probable chitinase 10 (EC 3.2.1.14) (Probable chitinase 1) (Probable chitinase 3)	Drosophila melanogaster (Fruit fly)	carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]	chitin binding [GO:0008061]; chitinase activity [GO:0004568]; endochitinase activity [GO:0008843]	extracellular region [GO:0005576]	GO:0004568; GO:0005576; GO:0005975; GO:0006032; GO:0008061; GO:0008843
GN012953	GN012953.1	H2A0L4	57.8	446	447	468	3.40e-192	545	CHI1_PINMG	Putative chitinase 1 (EC 3.2.1.14) (Chitinase-like protein 1) (Clp1)	Margaritifera margaritifera (Freshwater pearl mussel)	carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]	chitin binding [GO:0008061]; endochitinase activity [GO:0008843]	extracellular region [GO:0005576]	GO:0005576; GO:0005975; GO:0006032; GO:0008061; GO:0008843
GN012954	GN012954.1	H2A0L4	52.8	451	452	468	2.02e-175	502	CHI1_PINMG	Putative chitinase 1 (EC 3.2.1.14) (Chitinase-like protein 1) (Clp1)	Margaritifera margaritifera (Freshwater pearl mussel)	carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]	chitin binding [GO:0008061]; endochitinase activity [GO:0008843]	extracellular region [GO:0005576]	GO:0005576; GO:0005975; GO:0006032; GO:0008061; GO:0008843
GN012955	GN012955.1	H2A0L5	55.5	375	375	466	1.27e-150	436	CHI2_PINMG	Putative chitinase 2 (EC 3.2.1.14) (Chitinase-like protein 3) (Clp3)	Margaritifera margaritifera (Freshwater pearl mussel)	carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]	chitin binding [GO:0008061]; endochitinase activity [GO:0008843]	extracellular region [GO:0005576]	GO:0005576; GO:0005975; GO:0006032; GO:0008061; GO:0008843
GN012957	GN012957.1	Q5H8C1	35.9	2164	2147	2179	0.0	1298	FREM1_HUMAN	FRAS1-related extracellular matrix protein 1 (Protein QBRICK)	Homo sapiens (Human)	cell communication [GO:0007154]; cell-matrix adhesion [GO:0007160]; craniofacial suture morphogenesis [GO:0097094]; epithelial structure maintenance [GO:0010669]		basement membrane [GO:0005604]; extracellular matrix [GO:0031012]; membrane [GO:0016020]	GO:0005604; GO:0007154; GO:0007160; GO:0010669; GO:0016020; GO:0031012; GO:0097094
GN012958	GN012958.1	Q5F359	61.7	175	184	188	1.37e-78	235	TPPC5_CHICK	Trafficking protein particle complex subunit 5	Gallus gallus (Chicken)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]		endoplasmic reticulum [GO:0005783]; TRAPPI protein complex [GO:1990070]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]	GO:0005783; GO:0006888; GO:1990070; GO:1990071; GO:1990072
GN012959	GN012959.1	Q5H7C0	61.8	427	504	499	1.19e-190	544	CDC20_PIG	Cell division cycle protein 20 homolog (p55CDC)	Sus scrofa (Pig)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; metaphase/anaphase transition of cell cycle [GO:0044784]; metaphase/anaphase transition of meiosis I [GO:1990949]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]; positive regulation of meiotic cell cycle process involved in oocyte maturation [GO:1904146]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein ubiquitination [GO:0016567]	anaphase-promoting complex binding [GO:0010997]; ubiquitin ligase activator activity [GO:1990757]	anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; kinetochore [GO:0000776]; spindle pole [GO:0000922]	GO:0000776; GO:0000922; GO:0005680; GO:0005813; GO:0010997; GO:0016567; GO:0031145; GO:0031915; GO:0044784; GO:0090129; GO:1904146; GO:1904668; GO:1905786; GO:1990757; GO:1990949
GN012960	GN012960.1	Q7JK24	32.7	275	416	326	1.19e-42	155	B3GT1_GORGO	Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)	Gorilla gorilla gorilla (Western lowland gorilla)	glucosylceramide metabolic process [GO:0006678]; glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006678; GO:0008499; GO:0009101; GO:0009312
GN012962	GN012962.1	Q95M17	44.0	159	436	472	1.19e-37	145	CHIA_BOVIN	Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Chitin-binding protein b04) (CBPb04)	Bos taurus (Bovine)	carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; positive regulation of chemokine production [GO:0032722]; production of molecular mediator involved in inflammatory response [GO:0002532]	chitin binding [GO:0008061]; chitinase activity [GO:0004568]; endochitinase activity [GO:0008843]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]	GO:0002532; GO:0004568; GO:0005576; GO:0005737; GO:0005975; GO:0006032; GO:0008061; GO:0008843; GO:0032722
GN012964	GN012964.1	Q9W741	30.8	201	252	216	1.13e-21	92.8	NOGG1_DANRE	Noggin-1	Danio rerio (Zebrafish) (Brachydanio rerio)	dorsal/ventral pattern formation [GO:0009953]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of endodermal cell fate specification [GO:0042664]; osteoblast differentiation [GO:0001649]		extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; synapse [GO:0045202]	GO:0001649; GO:0005576; GO:0005794; GO:0009953; GO:0030514; GO:0042664; GO:0045202
GN012968	GN012968.1	Q7Z0T3	51.4	70	151	125	1.34e-11	61.2	TEMPT_APLCA	Temptin	Aplysia californica (California sea hare)			extracellular region [GO:0005576]	GO:0005576
GN012970	GN012970.1	O08934	85.6	111	396	530	7.02e-54	189	UNC4_MOUSE	Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1)	Mus musculus (Mouse)	cartilage condensation [GO:0001502]; common myeloid progenitor cell proliferation [GO:0035726]; dorsal spinal cord development [GO:0021516]; olfactory bulb interneuron differentiation [GO:0021889]; pattern specification process [GO:0007389]; regulation of cell differentiation [GO:0045595]; regulation of gene expression [GO:0010468]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]	GO:0000981; GO:0001502; GO:0005634; GO:0007389; GO:0010468; GO:0021516; GO:0021889; GO:0035726; GO:0045595; GO:1990837
GN012971	GN012971.1	A1Z3X3	50.2	277	296	323	2.37e-98	295	GET4_ORYLA	Golgi to ER traffic protein 4 homolog (Conserved edge expressed protein)	Oryzias latipes (Japanese rice fish) (Japanese killifish)	protein insertion into ER membrane [GO:0045048]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]	protein carrier activity [GO:0140597]	BAT3 complex [GO:0071818]; cytosol [GO:0005829]	GO:0005829; GO:0045048; GO:0071816; GO:0071818; GO:0140597
GN012972	GN012972.1	Q9CYU6	40.0	340	375	477	2.83e-83	264	DPH7_MOUSE	Diphthine methyltransferase (EC 3.1.1.97) (Diphthamide biosynthesis protein 7) (DPH7) (WD repeat-containing protein 85)	Mus musculus (Mouse)	protein histidyl modification to diphthamide [GO:0017183]	diphthine methylesterase activity [GO:0061685]; protein methylesterase activity [GO:0051723]	cytoplasm [GO:0005737]	GO:0005737; GO:0017183; GO:0051723; GO:0061685
GN012973	GN012973.1	Q08CX2	30.8	494	499	453	4.41e-57	199	SH24A_XENTR	SH2 domain-containing protein 4A	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		phosphatase binding [GO:0019902]; protein-macromolecule adaptor activity [GO:0030674]	cytoplasm [GO:0005737]	GO:0005737; GO:0019902; GO:0030674
GN012974	GN012974.1	Q5R754	69.7	307	680	493	1.72e-161	476	CDKL2_PONAB	Cyclin-dependent kinase-like 2 (EC 2.7.11.22)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)		ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0106310
GN012975	GN012975.1	F1LZF0	63.4	336	579	593	1.60e-150	448	KLHL2_RAT	Kelch-like protein 2 (Mayven)	Rattus norvegicus (Rat)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]	actin binding [GO:0003779]; identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	actin cytoskeleton [GO:0015629]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; ruffle [GO:0001726]	GO:0001726; GO:0003779; GO:0005737; GO:0005829; GO:0015629; GO:0016567; GO:0030027; GO:0030163; GO:0031463; GO:0042802; GO:0043161; GO:1990756
GN012983	GN012983.1	P42674	31.1	396	739	597	8.05e-42	164	BP10_PARLI	Blastula protease 10 (EC 3.4.24.-)	Paracentrotus lividus (Common sea urchin)	molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]	GO:0004222; GO:0005576; GO:0005938; GO:0006508; GO:0008270; GO:0018996; GO:0048471
GN012986	GN012986.1	P53992	62.3	800	1213	1094	0.0	995	SC24C_HUMAN	Protein transport protein Sec24C (SEC24-related protein C)	Homo sapiens (Human)	COPII-coated vesicle cargo loading [GO:0090110]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]	cargo adaptor activity [GO:0140312]; SNARE binding [GO:0000149]; zinc ion binding [GO:0008270]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]	GO:0000149; GO:0005783; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0008270; GO:0012507; GO:0030127; GO:0070863; GO:0090110; GO:0140312; GO:1902953
GN012987	GN012987.1	Q5R3Z6	52.5	122	197	124	2.69e-38	131	LTOR3_PONAB	Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	cellular response to amino acid stimulus [GO:0071230]; intracellular protein localization [GO:0008104]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]		late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; Ragulator complex [GO:0071986]	GO:0005765; GO:0008104; GO:0031902; GO:0032008; GO:0071230; GO:0071986; GO:1904263
GN012988	GN012988.1	A4IIK7	27.9	567	536	570	2.85e-64	222	NDNF_XENTR	Protein NDNF	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cellular response to fibroblast growth factor stimulus [GO:0044344]; extracellular matrix organization [GO:0030198]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron projection development [GO:0010976]	glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0001764; GO:0005539; GO:0005576; GO:0008201; GO:0010811; GO:0010976; GO:0021828; GO:0030198; GO:0031012; GO:0043524; GO:0044344
GN012989	GN012989.1	Q8BHI4	20.8	331	432	607	7.81e-13	73.9	KBTB3_MOUSE	Kelch repeat and BTB domain-containing protein 3 (BTB and kelch domain-containing protein 3)	Mus musculus (Mouse)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]	GO:0005737; GO:0031463; GO:0043161; GO:1990756
GN012990	GN012990.1	Q5RDY3	34.9	189	193	623	1.35e-34	131	KBTB2_PONAB	Kelch repeat and BTB domain-containing protein 2	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	protein ubiquitination [GO:0016567]			GO:0016567
GN012991	GN012991.1	Q9CZ49	27.5	211	305	574	8.48e-18	87.0	KLH35_MOUSE	Kelch-like protein 35	Mus musculus (Mouse)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]	GO:0005737; GO:0031463; GO:0043161; GO:1990756
GN012992	GN012992.1	Q4R7Y4	85.2	317	317	317	3.55e-192	533	GBLP_MACFA	Small ribosomal subunit protein RACK1 (Guanine nucleotide-binding protein subunit beta-2-like 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	cellular response to growth factor stimulus [GO:0071363]; negative regulation of cell growth [GO:0030308]; negative regulation of phagocytosis [GO:0050765]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of gastrulation [GO:2000543]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of GTPase activity [GO:0043547]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein-containing complex assembly [GO:0031334]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880]	protein kinase C binding [GO:0005080]; protein tyrosine kinase inhibitor activity [GO:0030292]; receptor tyrosine kinase binding [GO:0030971]; ribosome binding [GO:0043022]; SH2 domain binding [GO:0042169]; translation regulator activity [GO:0045182]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]	GO:0001891; GO:0001934; GO:0005080; GO:0005634; GO:0005737; GO:0030178; GO:0030292; GO:0030308; GO:0030335; GO:0030425; GO:0030496; GO:0030971; GO:0031334; GO:0032436; GO:0032880; GO:0042169; GO:0042998; GO:0043022; GO:0043025; GO:0043065; GO:0043204; GO:0043547; GO:0045182; GO:0048471; GO:0050765; GO:0051302; GO:0051726; GO:0071363; GO:2000114; GO:2000543
GN012993	GN012993.1	Q6TFL4	36.0	358	563	600	1.37e-63	222	KLH24_HUMAN	Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1)	Homo sapiens (Human)	intermediate filament organization [GO:0045109]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	adherens junction [GO:0005912]; axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; desmosome [GO:0030057]; perikaryon [GO:0043204]	GO:0005737; GO:0005912; GO:0016567; GO:0030057; GO:0030424; GO:0031463; GO:0043161; GO:0043204; GO:0045109; GO:0051865; GO:1990756
GN012994	GN012994.1	Q8BHI4	21.7	411	512	607	3.26e-27	119	KBTB3_MOUSE	Kelch repeat and BTB domain-containing protein 3 (BTB and kelch domain-containing protein 3)	Mus musculus (Mouse)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]	GO:0005737; GO:0031463; GO:0043161; GO:1990756
GN012995	GN012995.1	A4IIK7	27.9	567	536	570	2.85e-64	222	NDNF_XENTR	Protein NDNF	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cellular response to fibroblast growth factor stimulus [GO:0044344]; extracellular matrix organization [GO:0030198]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron projection development [GO:0010976]	glycosaminoglycan binding [GO:0005539]; heparin binding [GO:0008201]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0001764; GO:0005539; GO:0005576; GO:0008201; GO:0010811; GO:0010976; GO:0021828; GO:0030198; GO:0031012; GO:0043524; GO:0044344
GN013001	GN013001.1	Q96P65	33.1	293	407	431	1.28e-39	149	QRFPR_HUMAN	Pyroglutamylated RF-amide peptide receptor (AQ27) (G protein-coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)	Homo sapiens (Human)	cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]	G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0016020; GO:0032870
GN013005	GN013005.1	P31422	27.0	518	946	879	3.81e-41	167	GRM3_RAT	Metabotropic glutamate receptor 3 (mGluR3)	Rattus norvegicus (Rat)	cellular response to stress [GO:0033554]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; modulation of chemical synaptic transmission [GO:0050804]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]	calcium channel regulator activity [GO:0005246]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110]	astrocyte projection [GO:0097449]; axon [GO:0030424]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	GO:0001641; GO:0005246; GO:0005886; GO:0007216; GO:0010467; GO:0014069; GO:0019233; GO:0030424; GO:0033554; GO:0042734; GO:0043005; GO:0043197; GO:0045211; GO:0050804; GO:0051966; GO:0097110; GO:0097449; GO:0098978; GO:0099170
GN013006	GN013006.1	Q5RDQ8	26.8	497	1101	922	2.47e-42	171	GRM7_PONAB	Metabotropic glutamate receptor 7 (mGluR7)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; axon development [GO:0061564]	glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]; protein dimerization activity [GO:0046983]	plasma membrane [GO:0005886]	GO:0001642; GO:0005886; GO:0007196; GO:0008066; GO:0046983; GO:0061564
GN013007	GN013007.1	Q14831	26.7	490	1119	915	5.81e-42	170	GRM7_HUMAN	Metabotropic glutamate receptor 7 (mGluR7)	Homo sapiens (Human)	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; axon development [GO:0061564]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of glutamate secretion [GO:0014050]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of sound [GO:0007605]	adenylate cyclase inhibitor activity [GO:0010855]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; glutamate binding [GO:0016595]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]; PDZ domain binding [GO:0030165]; protein dimerization activity [GO:0046983]; serine binding [GO:0070905]; voltage-gated calcium channel activity [GO:0005245]	asymmetric synapse [GO:0032279]; axon [GO:0030424]; cell cortex [GO:0005938]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; signaling receptor complex [GO:0043235]	GO:0001642; GO:0005245; GO:0005246; GO:0005509; GO:0005886; GO:0005938; GO:0007193; GO:0007196; GO:0007216; GO:0007268; GO:0007605; GO:0008066; GO:0010855; GO:0014050; GO:0016020; GO:0016595; GO:0030165; GO:0030424; GO:0030425; GO:0032279; GO:0042734; GO:0043198; GO:0043235; GO:0045211; GO:0046983; GO:0048786; GO:0051966; GO:0061564; GO:0070905; GO:0098978; GO:0099171
GN013008	GN013008.1	Q86T96	42.4	66	336	592	1.42e-10	65.9	RN180_HUMAN	E3 ubiquitin-protein ligase RNF180 (EC 2.3.2.27) (RING finger protein 180) (RING-type E3 ubiquitin transferase RNF180)	Homo sapiens (Human)	norepinephrine metabolic process [GO:0042415]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; serotonin metabolic process [GO:0042428]	metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]	GO:0000209; GO:0005635; GO:0005789; GO:0031624; GO:0032436; GO:0042415; GO:0042428; GO:0046872; GO:0061630
GN013009	GN013009.1	I7MD46	22.0	323	996	2448	1.34e-10	69.7	CRMP1_TETTS	Cysteine repeat modular protein 1 (TtCRMP1) (EGF-like domain protein)	Tetrahymena thermophila (strain SB210)			membrane [GO:0016020]	GO:0016020
GN013011	GN013011.1	I7MD46	22.0	323	983	2448	5.86e-11	70.9	CRMP1_TETTS	Cysteine repeat modular protein 1 (TtCRMP1) (EGF-like domain protein)	Tetrahymena thermophila (strain SB210)			membrane [GO:0016020]	GO:0016020
GN013012	GN013012.1	Q8TEU7	46.7	1174	1544	1601	5.16e-318	948	RPGF6_HUMAN	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)	Homo sapiens (Human)	neuron projection development [GO:0031175]; positive regulation of microvillus assembly [GO:1903698]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of GTPase activity [GO:0043087]	GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidic acid binding [GO:0070300]; small GTPase binding [GO:0031267]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886]	GO:0005085; GO:0005829; GO:0005886; GO:0007265; GO:0016324; GO:0030139; GO:0030742; GO:0031175; GO:0031267; GO:0032486; GO:0043087; GO:0070300; GO:1903698
GN013013	GN013013.1	Q4I8B6	32.9	158	541	725	6.34e-12	72.0	AKR1_GIBZE	Palmitoyltransferase AKR1 (EC 2.3.1.225) (Ankyrin repeat-containing protein AKR1)	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)		protein-cysteine S-palmitoyltransferase activity [GO:0019706]	early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]	GO:0000139; GO:0019706; GO:0031901
GN013014	GN013014.1	Q4R627	32.5	618	577	581	2.50e-60	213	LARP7_MACFA	La-related protein 7 (La ribonucleoprotein domain family member 7)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	box C/D sno(s)RNA 3'-end processing [GO:0000494]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral transcription [GO:0032897]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of snRNA transcription by RNA polymerase II [GO:1905382]; regulation of mRNA splicing, via spliceosome [GO:0048024]; spermatogenesis [GO:0007283]; U6 2'-O-snRNA methylation [GO:1990438]	7SK snRNA binding [GO:0097322]; U6 snRNA binding [GO:0017070]	7SK snRNP [GO:0120259]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0000122; GO:0000494; GO:0005634; GO:0005654; GO:0007283; GO:0017070; GO:0032897; GO:0048024; GO:0097322; GO:0120259; GO:1904871; GO:1905382; GO:1990438; GO:1990904
GN013017	GN013017.1	Q86XX4	37.7	3804	3609	4008	0.0	2378	FRAS1_HUMAN	Extracellular matrix organizing protein FRAS1 (Fraser syndrome 1 protein)	Homo sapiens (Human)	animal organ development [GO:0048513]; cell communication [GO:0007154]; cell-matrix adhesion [GO:0007160]; epithelial structure maintenance [GO:0010669]; system development [GO:0048731]	extracellular matrix structural constituent [GO:0005201]	basement membrane [GO:0005604]; extracellular matrix [GO:0031012]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005201; GO:0005604; GO:0005886; GO:0007154; GO:0007160; GO:0010669; GO:0031012; GO:0048513; GO:0048731; GO:0140144
GN013018	GN013018.1	Q9Z1P6	52.6	76	115	113	4.54e-16	71.2	NDUA7_MOUSE	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (Complex I-B14.5a) (CI-B14.5a) (NADH-ubiquinone oxidoreductase subunit B14.5a)	Mus musculus (Mouse)	aerobic respiration [GO:0009060]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proton motive force-driven mitochondrial ATP synthesis [GO:0042776]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex I [GO:0045271]	GO:0005739; GO:0005743; GO:0006120; GO:0009060; GO:0042776; GO:0045271
GN013020	GN013020.1	A0A345BJN8	31.1	244	405	919	9.10e-23	104	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN013021	GN013021.1	Q14831	26.6	455	822	915	1.67e-39	161	GRM7_HUMAN	Metabotropic glutamate receptor 7 (mGluR7)	Homo sapiens (Human)	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway [GO:0007196]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; axon development [GO:0061564]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of glutamate secretion [GO:0014050]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of sound [GO:0007605]	adenylate cyclase inhibitor activity [GO:0010855]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; glutamate binding [GO:0016595]; glutamate receptor activity [GO:0008066]; group III metabotropic glutamate receptor activity [GO:0001642]; PDZ domain binding [GO:0030165]; protein dimerization activity [GO:0046983]; serine binding [GO:0070905]; voltage-gated calcium channel activity [GO:0005245]	asymmetric synapse [GO:0032279]; axon [GO:0030424]; cell cortex [GO:0005938]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; signaling receptor complex [GO:0043235]	GO:0001642; GO:0005245; GO:0005246; GO:0005509; GO:0005886; GO:0005938; GO:0007193; GO:0007196; GO:0007216; GO:0007268; GO:0007605; GO:0008066; GO:0010855; GO:0014050; GO:0016020; GO:0016595; GO:0030165; GO:0030424; GO:0030425; GO:0032279; GO:0042734; GO:0043198; GO:0043235; GO:0045211; GO:0046983; GO:0048786; GO:0051966; GO:0061564; GO:0070905; GO:0098978; GO:0099171
GN013022	GN013022.1	P15043	35.7	84	110	609	3.89e-09	55.8	RECQ_ECOLI	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Escherichia coli (strain K12)	DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; G-quadruplex unwinding activity [GO:0160225]; single-stranded DNA helicase activity [GO:0017116]; transition metal ion binding [GO:0046914]; zinc ion binding [GO:0008270]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]; single-stranded DNA-dependent ATP-dependent DNA helicase complex [GO:0017117]	GO:0003677; GO:0003678; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0006974; GO:0008094; GO:0008270; GO:0009432; GO:0016887; GO:0017116; GO:0017117; GO:0030894; GO:0043138; GO:0043590; GO:0046914; GO:0160225
GN013026	GN013026.1	Q5UR46	27.0	237	474	297	2.18e-11	68.2	YR571_MIMIV	Uncharacterized protein R571 (EC 3.1.1.-)	Acanthamoeba polyphaga mimivirus (APMV)	lipid catabolic process [GO:0016042]	hydrolase activity [GO:0016787]	membrane [GO:0016020]	GO:0016020; GO:0016042; GO:0016787
GN013027	GN013027.1	Q5UR46	26.6	237	529	297	1.52e-10	65.9	YR571_MIMIV	Uncharacterized protein R571 (EC 3.1.1.-)	Acanthamoeba polyphaga mimivirus (APMV)	lipid catabolic process [GO:0016042]	hydrolase activity [GO:0016787]	membrane [GO:0016020]	GO:0016020; GO:0016042; GO:0016787
GN013028	GN013028.1	Q8K4Y7	52.3	195	270	403	2.73e-67	217	CANT1_RAT	Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog)	Rattus norvegicus (Rat)	proteoglycan biosynthetic process [GO:0030166]	ADP phosphatase activity [GO:0043262]; calcium ion binding [GO:0005509]; GDP phosphatase activity [GO:0004382]; IDP phosphatase activity [GO:1990003]; nucleoside diphosphate phosphatase activity [GO:0017110]; protein homodimerization activity [GO:0042803]; UDP phosphatase activity [GO:0045134]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004382; GO:0005509; GO:0005789; GO:0005794; GO:0005886; GO:0016020; GO:0017110; GO:0030166; GO:0032580; GO:0042803; GO:0043262; GO:0045134; GO:1990003
GN013029	GN013029.1	Q9QYI4	50.7	286	315	376	5.89e-85	263	DJB12_MOUSE	DnaJ homolog subfamily B member 12 (mDj10)	Mus musculus (Mouse)	cellular response to misfolded protein [GO:0071218]; ERAD pathway [GO:0036503]; protein folding [GO:0006457]; protein-containing complex assembly [GO:0065003]	Hsp70 protein binding [GO:0030544]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]	GO:0005783; GO:0005789; GO:0006457; GO:0030544; GO:0031965; GO:0036503; GO:0065003; GO:0071218
GN013030	GN013030.1	Q9Y484	63.2	351	338	360	7.34e-161	456	WIPI4_HUMAN	WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45)	Homo sapiens (Human)	autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cellular response to starvation [GO:0009267]; glycophagy [GO:0061723]; nucleophagy [GO:0044804]; pexophagy [GO:0000425]; positive regulation of autophagosome assembly [GO:2000786]; protein localization to phagophore assembly site [GO:0034497]	phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]	cytoplasm [GO:0005737]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]	GO:0000045; GO:0000407; GO:0000422; GO:0000425; GO:0005737; GO:0006914; GO:0009267; GO:0019901; GO:0030674; GO:0032266; GO:0034045; GO:0034497; GO:0044804; GO:0061723; GO:0080025; GO:1901981; GO:2000786
GN013031	GN013031.1	Q6NZZ9	68.7	431	434	425	7.44e-211	590	RBM22_DANRE	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22)	Danio rerio (Zebrafish) (Brachydanio rerio)	chordate embryonic development [GO:0043009]; mRNA cis splicing, via spliceosome [GO:0045292]; positive regulation of RNA splicing [GO:0033120]	metal ion binding [GO:0046872]; pre-mRNA binding [GO:0036002]; U6 snRNA binding [GO:0017070]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000974; GO:0005634; GO:0005737; GO:0017070; GO:0033120; GO:0036002; GO:0043009; GO:0045292; GO:0046872; GO:0071006; GO:0071007
GN013046	GN013046.1	A4FV97	39.5	238	251	482	2.86e-47	166	RL1D1_BOVIN	Ribosomal L1 domain-containing protein 1	Bos taurus (Bovine)	regulation of apoptotic process [GO:0042981]; regulation of cellular senescence [GO:2000772]	mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]	nucleolus [GO:0005730]	GO:0003730; GO:0005730; GO:0042981; GO:0048027; GO:2000772
GN013048	GN013048.1	P08760	65.3	176	365	227	3.17e-77	240	KAD3_BOVIN	GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (Adenylate kinase isozyme 3)	Bos taurus (Bovine)	ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; GTP metabolic process [GO:0046039]; ITP metabolic process [GO:0046041]; nucleoside triphosphate biosynthetic process [GO:0009142]; UTP metabolic process [GO:0046051]	AMP kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside triphosphate adenylate kinase activity [GO:0046899]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004017; GO:0005524; GO:0005739; GO:0005759; GO:0006172; GO:0009142; GO:0046033; GO:0046039; GO:0046041; GO:0046051; GO:0046899
GN013051	GN013051.1	P18870	41.5	323	284	314	2.64e-62	202	JUN_CHICK	Transcription factor Jun (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun)	Gallus gallus (Chicken)	host-mediated activation of viral transcription [GO:0043923]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; response to steroid hormone [GO:0048545]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000976; GO:0000978; GO:0000981; GO:0005634; GO:0005667; GO:0042127; GO:0043923; GO:0045944; GO:0048545; GO:0051726
GN013053	GN013053.1	Q24157	37.3	252	374	325	1.77e-41	151	BRN_DROME	Beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase brn (EC 2.4.1.-) (Glycolipid-specific beta-1,3-N-Acetylglucosaminyltransferase brn) (Neurogenic secreted-signaling protein brn) (Protein brainiac) (UDP-GlcNAc:beta-Man/beta-Gal beta-1,3GlcNAc transferase) (beta3GlcNAc-transferase)	Drosophila melanogaster (Fruit fly)	arthro-series glucosylceramide biosynthetic process [GO:0140269]; border follicle cell migration [GO:0007298]; follicle cell of egg chamber development [GO:0030707]; follicle cell of egg chamber-cell adhesion [GO:0007299]; germarium-derived egg chamber formation [GO:0007293]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; insect visual primordium formation [GO:0001744]; maintenance of polarity of follicular epithelium [GO:0042248]; morphogenesis of follicular epithelium [GO:0016333]	beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity [GO:0046981]; UDP-glycosyltransferase activity [GO:0008194]	Golgi membrane [GO:0000139]	GO:0000139; GO:0001744; GO:0006688; GO:0007293; GO:0007298; GO:0007299; GO:0008194; GO:0009101; GO:0016333; GO:0030707; GO:0042248; GO:0046981; GO:0140269
GN013055	GN013055.1	Q24157	35.8	243	389	325	2.89e-45	161	BRN_DROME	Beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase brn (EC 2.4.1.-) (Glycolipid-specific beta-1,3-N-Acetylglucosaminyltransferase brn) (Neurogenic secreted-signaling protein brn) (Protein brainiac) (UDP-GlcNAc:beta-Man/beta-Gal beta-1,3GlcNAc transferase) (beta3GlcNAc-transferase)	Drosophila melanogaster (Fruit fly)	arthro-series glucosylceramide biosynthetic process [GO:0140269]; border follicle cell migration [GO:0007298]; follicle cell of egg chamber development [GO:0030707]; follicle cell of egg chamber-cell adhesion [GO:0007299]; germarium-derived egg chamber formation [GO:0007293]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; insect visual primordium formation [GO:0001744]; maintenance of polarity of follicular epithelium [GO:0042248]; morphogenesis of follicular epithelium [GO:0016333]	beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity [GO:0046981]; UDP-glycosyltransferase activity [GO:0008194]	Golgi membrane [GO:0000139]	GO:0000139; GO:0001744; GO:0006688; GO:0007293; GO:0007298; GO:0007299; GO:0008194; GO:0009101; GO:0016333; GO:0030707; GO:0042248; GO:0046981; GO:0140269
GN013056	GN013056.1	A6QLY2	53.8	145	159	186	6.71e-48	156	GPX7_BOVIN	Protein peroxidase GPX7 (GPx-7) (GSHPx-7) (EC 5.3.4.1)	Bos taurus (Bovine)	cellular response to oxidative stress [GO:0034599]	glutathione peroxidase activity [GO:0004602]; protein disulfide isomerase activity [GO:0003756]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	GO:0003756; GO:0004602; GO:0005783; GO:0005788; GO:0034599
GN013057	GN013057.1	Q6AYA1	72.3	101	188	226	7.08e-46	153	GAR1_RAT	H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1)	Rattus norvegicus (Rat)	snoRNA guided rRNA pseudouridine synthesis [GO:0000454]; telomere maintenance via telomerase [GO:0007004]	box H/ACA snoRNA binding [GO:0034513]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; Cajal body [GO:0015030]; chromosome, telomeric region [GO:0000781]; fibrillar center [GO:0001650]; telomerase holoenzyme complex [GO:0005697]	GO:0000454; GO:0000781; GO:0001650; GO:0003723; GO:0005697; GO:0007004; GO:0015030; GO:0031429; GO:0034513; GO:0070034; GO:0090661
GN013059	GN013059.1	Q9H5L6	35.3	116	117	903	8.02e-15	72.4	THAP9_HUMAN	DNA transposase THAP9 (EC 2.7.7.-) (THAP domain-containing protein 9) (hTh9)	Homo sapiens (Human)	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; DNA transposition [GO:0006313]	DNA binding [GO:0003677]; sequence-specific DNA binding [GO:0043565]; transposase activity [GO:0004803]		GO:0003677; GO:0004803; GO:0006310; GO:0006313; GO:0015074; GO:0043565
GN013060	GN013060.1	P14866	47.9	532	550	589	2.27e-155	459	HNRPL_HUMAN	Heterogeneous nuclear ribonucleoprotein L (hnRNP L)	Homo sapiens (Human)	mRNA processing [GO:0006397]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA processing [GO:0006396]	pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pronucleus [GO:0045120]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770]; synapse [GO:0045202]	GO:0000381; GO:0000785; GO:0000976; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006396; GO:0006397; GO:0016020; GO:0035770; GO:0045120; GO:0045202; GO:0045892; GO:0070062; GO:0097157; GO:1990904
GN013062	GN013062.1	P43114	31.7	322	438	488	2.78e-32	131	PE2R4_RAT	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Rattus norvegicus (Rat)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to glucose stimulus [GO:0071333]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nematode [GO:0009624]; response to progesterone [GO:0032570]; response to prostaglandin E [GO:0034695]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; response to xenobiotic stimulus [GO:0009410]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009410; GO:0009612; GO:0009624; GO:0010628; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032570; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060135; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0070555; GO:0071260; GO:0071333; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1902074; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1990785; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN013063	GN013063.1	O97508	51.5	99	109	105	1.21e-30	107	THIO_HORSE	Thioredoxin (Trx)	Equus caballus (Horse)	cellular homeostasis [GO:0019725]; positive regulation of DNA binding [GO:0043388]; response to radiation [GO:0009314]	protein-disulfide reductase activity [GO:0015035]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0005576; GO:0005634; GO:0005737; GO:0009314; GO:0015035; GO:0019725; GO:0043388
GN013064	GN013064.1	P32240	29.9	214	272	513	1.71e-20	94.0	PE2R4_MOUSE	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0000165; GO:0001818; GO:0001819; GO:0002792; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0008284; GO:0009624; GO:0010628; GO:0010840; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0071260; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1904496; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN013067	GN013067.1	Q8MJ08	37.2	199	257	492	2.98e-30	120	PE2R4_BOVIN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204]	prostaglandin E receptor activity [GO:0004957]	plasma membrane [GO:0005886]	GO:0004957; GO:0005886; GO:0006954; GO:0007188; GO:0007189; GO:0007204; GO:0033624; GO:0050728; GO:0071380; GO:2000420
GN013068	GN013068.1	P43114	27.6	319	328	488	2.66e-31	125	PE2R4_RAT	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Rattus norvegicus (Rat)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cAMP biosynthetic process [GO:0006171]; cAMP/PKA signal transduction [GO:0141156]; cellular response to glucose stimulus [GO:0071333]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of circadian sleep/wake cycle, wakefulness [GO:1904326]; negative regulation of cytokine production [GO:0001818]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin production [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of mucus secretion [GO:0070256]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of hippocampal neuron apoptotic process [GO:0110090]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of monoatomic ion transmembrane transport [GO:0034767]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein modification process [GO:0031401]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nematode [GO:0009624]; response to progesterone [GO:0032570]; response to prostaglandin E [GO:0034695]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; response to xenobiotic stimulus [GO:0009410]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006171; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009410; GO:0009612; GO:0009624; GO:0010628; GO:0014911; GO:0030278; GO:0031401; GO:0031965; GO:0032332; GO:0032496; GO:0032570; GO:0032690; GO:0032715; GO:0032717; GO:0032720; GO:0032733; GO:0032757; GO:0033624; GO:0034695; GO:0034767; GO:0035810; GO:0042093; GO:0042322; GO:0042466; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050714; GO:0050728; GO:0050729; GO:0051492; GO:0060135; GO:0060348; GO:0070256; GO:0070257; GO:0070371; GO:0070374; GO:0070555; GO:0071260; GO:0071333; GO:0071380; GO:0090303; GO:0097070; GO:0110090; GO:0141156; GO:1900127; GO:1902074; GO:1904326; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904471; GO:1990785; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2000573
GN013073	GN013073.1	Q32NW2	50.0	54	61	800	2.14e-09	54.3	LENG8_XENLA	Leukocyte receptor cluster member 8 homolog	Xenopus laevis (African clawed frog)			nucleus [GO:0005634]	GO:0005634
GN013074	GN013074.1	P98065	31.3	150	1076	276	3.71e-12	71.6	TSG6_RABIT	Tumor necrosis factor-inducible gene 6 protein (EC 3.1.1.-) (Hyaluronate-binding protein PS4) (TNF-stimulated gene 6 protein) (TSG-6) (Tumor necrosis factor alpha-induced protein 6) (TNF alpha-induced protein 6)	Oryctolagus cuniculus (Rabbit)	cell adhesion [GO:0007155]; fibronectin fibril organization [GO:1905590]; hyaluronan metabolic process [GO:0030212]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoclast differentiation [GO:0045671]; ovarian cumulus expansion [GO:0001550]; positive regulation of receptor clustering [GO:1903911]	calcium ion binding [GO:0005509]; carboxylesterase activity [GO:0106435]; fibronectin binding [GO:0001968]; hyaluronic acid binding [GO:0005540]	extracellular region [GO:0005576]	GO:0001550; GO:0001968; GO:0005509; GO:0005540; GO:0005576; GO:0007155; GO:0030212; GO:0030514; GO:0045668; GO:0045671; GO:0050728; GO:0090024; GO:0106435; GO:1903911; GO:1905590
GN013075	GN013075.1	P52186	41.7	319	391	427	1.04e-81	259	KCNJ2_CHICK	Inward rectifier potassium channel 2 (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)	Gallus gallus (Chicken)	potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]	inward rectifier potassium channel activity [GO:0005242]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]	GO:0005242; GO:0005546; GO:0005886; GO:0006813; GO:0016020; GO:0030315; GO:0051289; GO:1990573
GN013076	GN013076.1	Q14654	35.6	320	347	390	1.97e-61	204	KCJ11_HUMAN	ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)	Homo sapiens (Human)	glucose metabolic process [GO:0006006]; negative regulation of insulin secretion [GO:0046676]; nervous system process [GO:0050877]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transmembrane transport [GO:0071805]; regulation of insulin secretion [GO:0050796]; regulation of membrane potential [GO:0042391]; response to ATP [GO:0033198]; response to xenobiotic stimulus [GO:0009410]; transmembrane transport [GO:0055085]	ankyrin binding [GO:0030506]; ATP binding [GO:0005524]; ATP-activated inward rectifier potassium channel activity [GO:0015272]; ATPase-coupled monoatomic cation transmembrane transporter activity [GO:0019829]; potassium ion binding [GO:0030955]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]	cytoplasm [GO:0005737]; inward rectifying potassium channel [GO:0008282]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]	GO:0005249; GO:0005524; GO:0005737; GO:0005886; GO:0006006; GO:0008282; GO:0009410; GO:0015272; GO:0019829; GO:0030315; GO:0030506; GO:0030955; GO:0033198; GO:0042391; GO:0044325; GO:0046676; GO:0050796; GO:0050877; GO:0055085; GO:0071805; GO:0099508; GO:1990573
GN013077	GN013077.1	F1NHE9	37.6	327	406	429	5.83e-76	245	KCJ12_CHICK	ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (Potassium channel, inwardly rectifying subfamily J member 12)	Gallus gallus (Chicken)	potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]	identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]	membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]	GO:0005242; GO:0005886; GO:0006813; GO:0016020; GO:0030315; GO:0042802; GO:0051289; GO:1990573
GN013078	GN013078.1	P35408	24.8	322	283	488	1.34e-13	73.9	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of stress fiber assembly [GO:0051492]; response to mechanical stimulus [GO:0009612]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0009612; GO:0016020; GO:0033624; GO:0034695; GO:0042093; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070371; GO:0071260; GO:0071380; GO:2000420
GN013079	GN013079.1	F1NHE9	37.9	327	406	429	1.48e-76	246	KCJ12_CHICK	ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (Potassium channel, inwardly rectifying subfamily J member 12)	Gallus gallus (Chicken)	potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]	identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]	membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]	GO:0005242; GO:0005886; GO:0006813; GO:0016020; GO:0030315; GO:0042802; GO:0051289; GO:1990573
GN013080	GN013080.1	P48048	35.7	339	347	391	5.64e-61	203	KCNJ1_HUMAN	ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1)	Homo sapiens (Human)	gene expression [GO:0010467]; monoatomic ion transport [GO:0006811]; potassium ion import across plasma membrane [GO:1990573]; regulation of monoatomic ion transmembrane transport [GO:0034765]	ATP binding [GO:0005524]; inward rectifier potassium channel activity [GO:0005242]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; potassium channel activity [GO:0005267]	cell surface [GO:0009986]; plasma membrane [GO:0005886]	GO:0005242; GO:0005267; GO:0005524; GO:0005546; GO:0005886; GO:0006811; GO:0009986; GO:0010467; GO:0034765; GO:1990573
GN013081	GN013081.1	P52186	41.7	319	391	427	2.63e-82	261	KCNJ2_CHICK	Inward rectifier potassium channel 2 (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)	Gallus gallus (Chicken)	potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]	inward rectifier potassium channel activity [GO:0005242]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	membrane [GO:0016020]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]	GO:0005242; GO:0005546; GO:0005886; GO:0006813; GO:0016020; GO:0030315; GO:0051289; GO:1990573
GN013082	GN013082.1	P98065	31.3	150	999	276	3.39e-12	71.6	TSG6_RABIT	Tumor necrosis factor-inducible gene 6 protein (EC 3.1.1.-) (Hyaluronate-binding protein PS4) (TNF-stimulated gene 6 protein) (TSG-6) (Tumor necrosis factor alpha-induced protein 6) (TNF alpha-induced protein 6)	Oryctolagus cuniculus (Rabbit)	cell adhesion [GO:0007155]; fibronectin fibril organization [GO:1905590]; hyaluronan metabolic process [GO:0030212]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoclast differentiation [GO:0045671]; ovarian cumulus expansion [GO:0001550]; positive regulation of receptor clustering [GO:1903911]	calcium ion binding [GO:0005509]; carboxylesterase activity [GO:0106435]; fibronectin binding [GO:0001968]; hyaluronic acid binding [GO:0005540]	extracellular region [GO:0005576]	GO:0001550; GO:0001968; GO:0005509; GO:0005540; GO:0005576; GO:0007155; GO:0030212; GO:0030514; GO:0045668; GO:0045671; GO:0050728; GO:0090024; GO:0106435; GO:1903911; GO:1905590
GN013088	GN013088.1	Q6GPB9	44.6	733	847	742	8.10e-206	605	DNAI4_XENLA	Dynein axonemal intermediate chain 4 (WD repeat-containing protein 78)	Xenopus laevis (African clawed frog)	cilium movement [GO:0003341]	dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]	axonemal dynein complex [GO:0005858]; dynein axonemal particle [GO:0120293]	GO:0003341; GO:0005858; GO:0045503; GO:0045504; GO:0120293
GN013091	GN013091.1	Q7T105	41.8	359	514	495	1.98e-78	257	MIER1_XENLA	Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (Xmi-er1)	Xenopus laevis (African clawed frog)	chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of DNA-templated transcription [GO:0006355]	histone deacetylase binding [GO:0042826]; transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; transcription repressor complex [GO:0017053]	GO:0000122; GO:0003714; GO:0005654; GO:0006338; GO:0006355; GO:0017053; GO:0042826
GN013093	GN013093.1	P63032	43.7	174	230	266	2.55e-37	134	RHES_MOUSE	GTP-binding protein Rhes (Ras homolog enriched in striatum)	Mus musculus (Mouse)	locomotory behavior [GO:0007626]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein sumoylation [GO:0033235]; signal transduction [GO:0007165]; synaptic transmission, dopaminergic [GO:0001963]	G-protein beta-subunit binding [GO:0031681]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phosphatidylinositol 3-kinase binding [GO:0043548]; ubiquitin conjugating enzyme binding [GO:0031624]	plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0001963; GO:0003924; GO:0005525; GO:0005886; GO:0007165; GO:0007626; GO:0031397; GO:0031624; GO:0031681; GO:0033235; GO:0043548; GO:0045202; GO:0051897
GN013094	GN013094.1	Q7ZXH7	40.7	182	228	184	5.32e-38	133	RAP1B_XENLA	Ras-related protein Rap-1b (EC 3.6.5.2)	Xenopus laevis (African clawed frog)	cellular response to cAMP [GO:0071320]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; Rap protein signal transduction [GO:0032486]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	anchoring junction [GO:0070161]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005525; GO:0005829; GO:0005886; GO:0032486; GO:0070161; GO:0071320; GO:2000301
GN013095	GN013095.1	Q7ZXH7	40.7	182	226	184	1.25e-38	135	RAP1B_XENLA	Ras-related protein Rap-1b (EC 3.6.5.2)	Xenopus laevis (African clawed frog)	cellular response to cAMP [GO:0071320]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; Rap protein signal transduction [GO:0032486]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	anchoring junction [GO:0070161]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005525; GO:0005829; GO:0005886; GO:0032486; GO:0070161; GO:0071320; GO:2000301
GN013097	GN013097.1	D3ZWJ9	22.1	390	725	624	7.32e-19	94.7	F234B_RAT	Protein FAM234B	Rattus norvegicus (Rat)			membrane [GO:0016020]; microtubule organizing center [GO:0005815]; postsynaptic Golgi apparatus [GO:0150051]	GO:0005815; GO:0016020; GO:0150051
GN013100	GN013100.1	P25931	34.6	191	200	464	5.09e-27	109	RYAR_DROME	RYamide receptor (Neuropeptide Y-like receptor) (NPY-R)	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0004983; GO:0005886; GO:0007186; GO:0007218; GO:0008188; GO:0016020
GN013101	GN013101.1	P49683	45.1	71	139	370	8.27e-18	81.3	PRLHR_HUMAN	Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G protein-coupled receptor 10) (hGR3)	Homo sapiens (Human)	feeding behavior [GO:0007631]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]	cilium [GO:0005929]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	GO:0004930; GO:0004983; GO:0005886; GO:0005929; GO:0007186; GO:0007218; GO:0007565; GO:0007631; GO:0008188; GO:0043005
GN013102	GN013102.1	P25931	39.7	252	260	464	8.43e-51	175	RYAR_DROME	RYamide receptor (Neuropeptide Y-like receptor) (NPY-R)	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0004983; GO:0005886; GO:0007186; GO:0007218; GO:0008188; GO:0016020
GN013107	GN013107.1	P00367	73.2	515	539	558	2.72e-280	775	DHE3_HUMAN	Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)	Homo sapiens (Human)	L-glutamate biosynthetic process [GO:0097054]; L-glutamate catabolic process [GO:0006538]; L-glutamine metabolic process [GO:0006541]; positive regulation of insulin secretion [GO:0032024]; substantia nigra development [GO:0021762]; tricarboxylic acid metabolic process [GO:0072350]	ADP binding [GO:0043531]; GTP binding [GO:0005525]; L-glutamate dehydrogenase (NAD+) activity [GO:0004352]; L-glutamate dehydrogenase (NADP+) activity [GO:0004354]; L-glutamate dehydrogenase [NAD(P)+] activity [GO:0004353]; L-leucine binding [GO:0070728]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004352; GO:0004353; GO:0004354; GO:0005525; GO:0005737; GO:0005739; GO:0005759; GO:0005783; GO:0006538; GO:0006541; GO:0021762; GO:0032024; GO:0042803; GO:0043531; GO:0070403; GO:0070728; GO:0072350; GO:0097054
GN013109	GN013109.1	A2BHJ4	62.5	64	142	559	1.53e-20	89.7	CNO6L_DANRE	CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4)	Danio rerio (Zebrafish) (Brachydanio rerio)	nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]	3'-5'-RNA exonuclease activity [GO:0000175]; poly(A)-specific ribonuclease activity [GO:0004535]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000175; GO:0000289; GO:0004535; GO:0005634; GO:0005737; GO:0030014
GN013110	GN013110.1	Q8VEG6	58.1	377	866	555	1.86e-152	462	CNO6L_MOUSE	CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4)	Mus musculus (Mouse)	mRNA destabilization [GO:0061157]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]	3'-5'-RNA exonuclease activity [GO:0000175]; poly(A)-specific ribonuclease activity [GO:0004535]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000175; GO:0000288; GO:0000289; GO:0004535; GO:0005634; GO:0005737; GO:0005829; GO:0008284; GO:0010606; GO:0030014; GO:0061157
GN013111	GN013111.1	P09208	25.6	199	1604	2144	5.65e-12	75.1	INSR_DROME	Insulin-like receptor (dIR) (dInr) (dmIR) (EC 2.7.10.1) (Insulin receptor homolog) (dIRH) (Receptor protein-tyrosine kinase InR) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1 (Insulin-like receptor subunit beta 170 kDa form) (beta170); Insulin-like receptor subunit beta 2 (Insulin-like receptor subunit beta 90 kDa form) (beta90); 60 kDa C-terminal fragment (Insulin-like receptor free C-terminus)]	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; carbohydrate homeostasis [GO:0033500]; cellular response to starvation [GO:0009267]; cholesterol homeostasis [GO:0042632]; circadian rhythm [GO:0007623]; determination of adult lifespan [GO:0008340]; developmental growth [GO:0048589]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic development via the syncytial blastoderm [GO:0001700]; female germ-line stem cell asymmetric division [GO:0048132]; female germ-line stem cell population maintenance [GO:0036099]; female gonad development [GO:0008585]; female mating behavior [GO:0060180]; follicle cell of egg chamber development [GO:0030707]; germ-band shortening [GO:0007390]; germ-line stem cell division [GO:0042078]; germ-line stem-cell niche homeostasis [GO:0060250]; glucose homeostasis [GO:0042593]; imaginal disc growth [GO:0007446]; insulin receptor signaling pathway [GO:0008286]; intestinal stem cell homeostasis [GO:0036335]; lipid homeostasis [GO:0055088]; locomotory behavior [GO:0007626]; lymph gland development [GO:0048542]; male germ-line stem cell asymmetric division [GO:0048133]; multicellular organism growth [GO:0035264]; negative regulation of circadian sleep/wake cycle, sleep [GO:0042321]; negative regulation of entry into reproductive diapause [GO:0061964]; negative regulation of feeding behavior [GO:2000252]; negative regulation of macroautophagy [GO:0016242]; negative regulation of peptide hormone secretion [GO:0090278]; nervous system development [GO:0007399]; open tracheal system development [GO:0007424]; positive regulation of border follicle cell migration [GO:1903688]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell size [GO:0045793]; positive regulation of fat cell proliferation [GO:0070346]; positive regulation of lipid storage [GO:0010884]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron remodeling [GO:1904801]; positive regulation of organ growth [GO:0046622]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of wound healing [GO:0090303]; primary spermatocyte growth [GO:0007285]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell population proliferation [GO:0042127]; regulation of multicellular organism growth [GO:0040014]; regulation of organ growth [GO:0046620]; response to anoxia [GO:0034059]; response to cocaine [GO:0042220]; response to oxidative stress [GO:0006979]; triglyceride homeostasis [GO:0070328]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; insulin receptor activity [GO:0005009]; insulin receptor substrate binding [GO:0043560]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein tyrosine kinase activity [GO:0004713]	axon [GO:0030424]; growth cone membrane [GO:0032584]; insulin receptor complex [GO:0005899]; plasma membrane [GO:0005886]	GO:0001700; GO:0002052; GO:0004713; GO:0005009; GO:0005524; GO:0005886; GO:0005899; GO:0006468; GO:0006979; GO:0007285; GO:0007390; GO:0007399; GO:0007411; GO:0007424; GO:0007446; GO:0007623; GO:0007626; GO:0008284; GO:0008286; GO:0008340; GO:0008585; GO:0009267; GO:0009792; GO:0010884; GO:0016242; GO:0030307; GO:0030424; GO:0030707; GO:0032584; GO:0033500; GO:0034059; GO:0035264; GO:0036099; GO:0036335; GO:0040014; GO:0040018; GO:0042078; GO:0042127; GO:0042220; GO:0042321; GO:0042593; GO:0042632; GO:0042802; GO:0043410; GO:0043548; GO:0043559; GO:0043560; GO:0045793; GO:0046620; GO:0046622; GO:0046777; GO:0048132; GO:0048133; GO:0048542; GO:0048589; GO:0051897; GO:0055088; GO:0060180; GO:0060250; GO:0061964; GO:0070328; GO:0070346; GO:0090278; GO:0090303; GO:1903688; GO:1904263; GO:1904801; GO:2000252
GN013113	GN013113.1	Q9FT72	27.3	385	432	713	8.45e-23	104	RQL3_ARATH	ATP-dependent DNA helicase Q-like 3 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ3) (RecQ-like protein 3) (AtRecQ3) (AtRecQl3)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004386; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006310; GO:0009378; GO:0016887; GO:0043138; GO:1990814
GN013115	GN013115.1	Q9M2U3	28.3	314	378	406	1.42e-31	126	ALPL_ARATH	Protein ALP1-like (EC 3.1.-.-)	Arabidopsis thaliana (Mouse-ear cress)			histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634
GN013117	GN013117.1	Q9N295	31.9	248	393	297	3.34e-35	134	B3GT5_PANTR	Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)	Pan troglodytes (Chimpanzee)	glycoprotein biosynthetic process [GO:0009101]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0008499; GO:0009101
GN013122	GN013122.1	Q9ERD9	37.9	346	357	407	4.67e-74	238	I23O1_RAT	Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)	Rattus norvegicus (Rat)	'de novo' NAD+ biosynthetic process from L-tryptophan [GO:0034354]; inflammatory response [GO:0006954]; kynurenic acid biosynthetic process [GO:0034276]; L-tryptophan catabolic process [GO:0006569]; multicellular organismal response to stress [GO:0033555]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chronic inflammatory response [GO:0002678]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of T cell apoptotic process [GO:0070234]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of type 2 immune response [GO:0002830]; quinolinate biosynthetic process [GO:0019805]; response to lipopolysaccharide [GO:0032496]; swimming behavior [GO:0036269]	amino acid binding [GO:0016597]; heme binding [GO:0020037]; indoleamine 2,3-dioxygenase activity [GO:0033754]; L-tryptophan 2,3-dioxygenase activity [GO:0004833]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; smooth muscle contractile fiber [GO:0030485]; stereocilium bundle [GO:0032421]	GO:0002666; GO:0002678; GO:0002830; GO:0004833; GO:0005737; GO:0005829; GO:0006569; GO:0006954; GO:0016597; GO:0019805; GO:0020037; GO:0030485; GO:0032421; GO:0032496; GO:0032693; GO:0032735; GO:0033555; GO:0033754; GO:0034276; GO:0034354; GO:0036269; GO:0042130; GO:0043065; GO:0046007; GO:0046872; GO:0070233; GO:0070234
GN013124	GN013124.1	Q7SXM7	65.1	441	430	508	7.97e-184	524	PRP31_DANRE	U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31)	Danio rerio (Zebrafish) (Brachydanio rerio)	mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; retina development in camera-type eye [GO:0060041]; spliceosomal tri-snRNP complex assembly [GO:0000244]	U4atac snRNA binding [GO:0030622]	Cajal body [GO:0015030]; MLL1 complex [GO:0071339]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690]	GO:0000244; GO:0000381; GO:0000398; GO:0005634; GO:0005687; GO:0005690; GO:0015030; GO:0016607; GO:0030622; GO:0046540; GO:0060041; GO:0071005; GO:0071011; GO:0071339; GO:0097526
GN013126	GN013126.1	Q6IR74	35.0	622	643	651	5.15e-120	374	CTL1_XENLA	Choline transporter-like protein 1 (Solute carrier family 44 member 1)	Xenopus laevis (African clawed frog)	choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; transmembrane transport [GO:0055085]	choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]	mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]	GO:0005741; GO:0005886; GO:0015220; GO:0015871; GO:0034228; GO:0034229; GO:0055085
GN013130	GN013130.1	P55809	67.5	194	198	520	5.21e-77	242	SCOT1_HUMAN	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase)	Homo sapiens (Human)	adipose tissue development [GO:0060612]; heart development [GO:0007507]; ketone body catabolic process [GO:0046952]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; response to activity [GO:0014823]; response to ethanol [GO:0045471]; response to hormone [GO:0009725]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to xenobiotic stimulus [GO:0009410]	identical protein binding [GO:0042802]; succinyl-CoA:3-oxo-acid CoA-transferase activity [GO:0008260]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0007507; GO:0007584; GO:0008260; GO:0009410; GO:0009725; GO:0014823; GO:0035774; GO:0042594; GO:0042802; GO:0045471; GO:0046952; GO:0060612
GN013131	GN013131.1	Q24547	30.1	256	307	291	2.09e-23	100	STX1A_DROME	Syntaxin-1A (dSynt1)	Drosophila melanogaster (Fruit fly)	cellularization [GO:0007349]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; haltere development [GO:0007482]; intracellular protein transport [GO:0006886]; liquid clearance, open tracheal system [GO:0035002]; membrane fusion [GO:0061025]; mitotic cytokinesis [GO:0000281]; neurotransmitter secretion [GO:0007269]; regulation of pole plasm oskar mRNA localization [GO:0007317]; secretion of lysosomal enzymes [GO:0033299]; synaptic vesicle docking [GO:0016081]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]	SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]	lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	GO:0000149; GO:0000281; GO:0005484; GO:0005765; GO:0005886; GO:0006886; GO:0006887; GO:0006906; GO:0007269; GO:0007317; GO:0007349; GO:0007482; GO:0008021; GO:0016081; GO:0016192; GO:0030672; GO:0031201; GO:0031629; GO:0033299; GO:0035002; GO:0043195; GO:0048278; GO:0061025; GO:1990182
GN013132	GN013132.1	B2GV06	64.2	240	245	520	3.22e-103	311	SCOT1_RAT	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase)	Rattus norvegicus (Rat)	adipose tissue development [GO:0060612]; heart development [GO:0007507]; ketone body catabolic process [GO:0046952]; ketone catabolic process [GO:0042182]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; response to activity [GO:0014823]; response to ethanol [GO:0045471]; response to hormone [GO:0009725]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to xenobiotic stimulus [GO:0009410]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; succinyl-CoA:3-oxo-acid CoA-transferase activity [GO:0008260]	mitochondrion [GO:0005739]	GO:0005739; GO:0007507; GO:0007584; GO:0008260; GO:0009410; GO:0009725; GO:0014823; GO:0035774; GO:0042182; GO:0042594; GO:0042802; GO:0042803; GO:0045471; GO:0046952; GO:0060612
GN013135	GN013135.1	C9JTQ0	39.8	128	382	380	3.58e-18	88.6	ANR63_HUMAN	Ankyrin repeat domain-containing protein 63	Homo sapiens (Human)				
GN013136	GN013136.1	Q8IUF1	57.1	312	386	395	2.12e-122	362	ZNG1B_HUMAN	Zinc-regulated GTPase metalloprotein activator 1B (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 2) (COBW domain-containing protein 2)	Homo sapiens (Human)	protein maturation [GO:0051604]	GTPase activity [GO:0003924]; zinc chaperone activity [GO:0140827]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0003924; GO:0005634; GO:0008270; GO:0051604; GO:0140827
GN013140	GN013140.1	Q3U6K5	27.6	539	513	488	2.01e-36	144	SPAT6_MOUSE	Spermatogenesis-associated protein 6 (Kinesin-related protein)	Mus musculus (Mouse)	motile cilium assembly [GO:0044458]; spermatogenesis [GO:0007283]	myosin light chain binding [GO:0032027]	extracellular region [GO:0005576]; motile cilium [GO:0031514]; sperm head-tail coupling apparatus [GO:0120212]	GO:0005576; GO:0007283; GO:0031514; GO:0032027; GO:0044458; GO:0120212
GN013142	GN013142.1	Q2NL11	27.2	257	301	293	1.32e-21	95.5	CH074_BOVIN	Uncharacterized protein C8orf74 homolog	Bos taurus (Bovine)				
GN013143	GN013143.1	B5FZ19	68.8	324	322	325	1.70e-170	479	EIF3I_TAEGU	Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (eIF-3-beta) (eIF3 p36)	Taeniopygia guttata (Zebra finch) (Poephila guttata)	formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; synapse [GO:0045202]	GO:0001732; GO:0003723; GO:0003743; GO:0005852; GO:0006413; GO:0016282; GO:0033290; GO:0045202; GO:0071541
GN013146	GN013146.1	Q55E58	26.5	446	723	3184	1.28e-18	95.1	PATS1_DICDI	Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1)	Dictyostelium discoideum (Social amoeba)	cheating during chimeric sorocarp development [GO:0099139]; mitotic cytokinesis [GO:0000281]; phosphatidylinositol dephosphorylation [GO:0046856]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actomyosin [GO:0042641]; cytosol [GO:0005829]; membrane [GO:0016020]	GO:0000281; GO:0004438; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0005829; GO:0016020; GO:0042641; GO:0046856; GO:0099139; GO:0106310
GN013149	GN013149.1	Q5G270	37.1	744	1514	876	5.01e-140	456	NETR_GORGO	Neurotrypsin (EC 3.4.21.-) (Serine protease 12)	Gorilla gorilla gorilla (Western lowland gorilla)	exocytosis [GO:0006887]; zymogen activation [GO:0031638]	serine-type endopeptidase activity [GO:0004252]	axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; synaptic cleft [GO:0043083]; terminal bouton [GO:0043195]	GO:0004252; GO:0005886; GO:0006887; GO:0030424; GO:0030425; GO:0031638; GO:0043083; GO:0043195; GO:0098978
GN013150	GN013150.1	O35250	47.3	74	74	697	6.00e-16	73.6	EXOC7_MOUSE	Exocyst complex component 7 (Exocyst complex component Exo70)	Mus musculus (Mouse)	membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; positive regulation of mitotic cytokinetic process [GO:1903438]; protein localization to ciliary membrane [GO:1903441]; protein transmembrane transport [GO:0071806]; regulation of entry of bacterium into host cell [GO:2000535]; regulation of synapse assembly [GO:0051963]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-macromolecule adaptor activity [GO:0030674]	9+0 non-motile cilium [GO:0097731]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone membrane [GO:0032584]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]	GO:0000145; GO:0000281; GO:0005546; GO:0005815; GO:0005829; GO:0005886; GO:0006904; GO:0030496; GO:0030674; GO:0032154; GO:0032584; GO:0034451; GO:0036064; GO:0051963; GO:0071806; GO:0090148; GO:0090522; GO:0090543; GO:0097546; GO:0097731; GO:0098793; GO:0098794; GO:1903438; GO:1903441; GO:2000535
GN013151	GN013151.1	Q9Y2W2	42.9	648	567	641	1.30e-53	196	WBP11_HUMAN	WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1)	Homo sapiens (Human)	RNA splicing [GO:0008380]	protein phosphatase regulator activity [GO:0019888]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; WW domain binding [GO:0050699]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003697; GO:0003723; GO:0005634; GO:0005654; GO:0005829; GO:0008380; GO:0019888; GO:0050699
GN013152	GN013152.1	F1R8Z9	40.5	333	428	442	1.44e-64	216	FXJ1B_DANRE	Forkhead box protein J1-B	Danio rerio (Zebrafish) (Brachydanio rerio)	auditory receptor cell stereocilium organization [GO:0060088]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; heart jogging [GO:0003146]; heart looping [GO:0001947]; motile cilium assembly [GO:0044458]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001947; GO:0003146; GO:0005634; GO:0006357; GO:0007368; GO:0044458; GO:0060088; GO:0060271
GN013153	GN013153.1	Q66HY8	39.1	161	215	751	1.55e-25	107	PDXD1_DANRE	Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-)	Danio rerio (Zebrafish) (Brachydanio rerio)				
GN013156	GN013156.1	Q5XGZ9	34.1	346	508	614	9.44e-56	199	MF6LB_XENLA	Major facilitator superfamily domain-containing protein 6-like protein B	Xenopus laevis (African clawed frog)			membrane [GO:0016020]	GO:0016020
GN013158	GN013158.1	P18433	29.6	588	668	802	2.07e-71	250	PTPRA_HUMAN	Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)	Homo sapiens (Human)	integrin-mediated signaling pathway [GO:0007229]; regulation of focal adhesion assembly [GO:0051893]; signal transduction [GO:0007165]	protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004725; GO:0005001; GO:0005886; GO:0005925; GO:0007165; GO:0007229; GO:0016020; GO:0043235; GO:0051893; GO:0070062
GN013161	GN013161.1	Q8AY73	64.0	975	968	971	0.0	1221	XPO2_ORENI	Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)	Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)	protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]	nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]	GO:0005049; GO:0005634; GO:0005635; GO:0005737; GO:0005829; GO:0006606; GO:0006611; GO:0031267
GN013165	GN013165.1	Q8T3B9	70.3	101	332	404	1.75e-41	152	SEM2_CAEEL	Transcription factor sem-2 (Sex muscle abnormal protein 2)	Caenorhabditis elegans	brain development [GO:0007420]; mesodermal cell fate specification [GO:0007501]; myoblast fate specification [GO:0048626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of egg-laying behavior [GO:1901046]; positive regulation of embryonic development [GO:0040019]; positive regulation of mesodermal cell fate specification [GO:0048337]; positive regulation of post-embryonic development [GO:0048582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vulval development [GO:0040026]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0001228; GO:0003677; GO:0005634; GO:0007420; GO:0007501; GO:0030182; GO:0040019; GO:0040026; GO:0045944; GO:0048337; GO:0048582; GO:0048626; GO:1901046
GN013166	GN013166.1	P18948	22.3	1048	2565	1651	1.50e-54	215	VIT6_CAEEL	Vitellogenin-6	Caenorhabditis elegans	lipid transport [GO:0006869]; negative regulation of protein oxidation [GO:1904807]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; positive regulation of cholesterol import [GO:1904109]	lipid carrier activity [GO:0005319]	extracellular region [GO:0005576]	GO:0005319; GO:0005576; GO:0006869; GO:1903427; GO:1904109; GO:1904807
GN013167	GN013167.1	Q90YY5	67.8	59	612	597	6.54e-15	81.6	MED26_XENLA	Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26)	Xenopus laevis (African clawed frog)	positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]	transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]	GO:0003712; GO:0005654; GO:0006357; GO:0010628; GO:0016592; GO:0070847
GN013168	GN013168.1	Q15468	38.1	446	1495	1287	5.00e-77	284	STIL_HUMAN	SCL-interrupting locus protein (TAL-1-interrupting locus protein)	Homo sapiens (Human)	centrosome duplication [GO:0051298]; determination of left/right symmetry [GO:0007368]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; forebrain development [GO:0030900]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; microtubule organizing center organization [GO:0031023]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; notochord development [GO:0030903]; positive regulation of centriole replication [GO:0046601]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of spindle assembly [GO:1905832]; protein localization to centrosome [GO:0071539]; regulation of centriole replication [GO:0046599]; regulation of mitotic spindle organization [GO:0060236]; smoothened signaling pathway [GO:0007224]	identical protein binding [GO:0042802]	cell cortex [GO:0005938]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; procentriole replication complex [GO:0120099]	GO:0000578; GO:0001701; GO:0001843; GO:0001947; GO:0005737; GO:0005813; GO:0005814; GO:0005815; GO:0005829; GO:0005938; GO:0007052; GO:0007224; GO:0007368; GO:0021915; GO:0030900; GO:0030903; GO:0031023; GO:0033504; GO:0035264; GO:0036064; GO:0042802; GO:0043066; GO:0046599; GO:0046601; GO:0051298; GO:0060236; GO:0071539; GO:0120099; GO:1900087; GO:1905832
GN013169	GN013169.1	Q84JE8	28.3	336	327	694	4.79e-16	82.4	ZDP_ARATH	Polynucleotide 3'-phosphatase ZDP (EC 3.1.3.32) (DNA nick sensor protein)	Arabidopsis thaliana (Mouse-ear cress)	base-excision repair [GO:0006284]; DNA repair [GO:0006281]; double-strand break repair via nonhomologous end joining [GO:0006303]; single strand break repair [GO:0000012]	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; DNA binding [GO:0003677]; polynucleotide 3'-phosphatase activity [GO:0046403]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000012; GO:0003677; GO:0005634; GO:0005654; GO:0006281; GO:0006284; GO:0006303; GO:0008270; GO:0046403; GO:0046404
GN013170	GN013170.1	Q5ZKE7	56.6	173	277	196	7.79e-59	189	KCY_CHICK	UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK)	Gallus gallus (Chicken)	'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; CDP biosynthetic process [GO:0046705]; UDP biosynthetic process [GO:0006225]	ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]; UMP kinase activity [GO:0033862]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004550; GO:0005524; GO:0005634; GO:0005737; GO:0006207; GO:0006225; GO:0033862; GO:0036430; GO:0036431; GO:0046705
GN013171	GN013171.1	Q9CXL3	46.3	95	378	195	1.78e-17	83.2	CHOLN_MOUSE	Cholesin (Protein C7orf50 homolog)	Mus musculus (Mouse)	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; negative regulation of cholesterol biosynthetic process [GO:0045541]; positive regulation of cholesterol biosynthetic process [GO:0045542]; regulation of cholesterol biosynthetic process [GO:0045540]	hormone activity [GO:0005179]	extracellular region [GO:0005576]	GO:0005179; GO:0005576; GO:0007193; GO:0045540; GO:0045541; GO:0045542
GN013172	GN013172.1	Q5BJE1	21.2	853	928	867	1.11e-19	98.6	CC178_HUMAN	Coiled-coil domain-containing protein 178	Homo sapiens (Human)	manchette assembly [GO:1905198]; spermatid development [GO:0007286]		centrosome [GO:0005813]; ciliary basal body [GO:0036064]	GO:0005813; GO:0007286; GO:0036064; GO:1905198
GN013173	GN013173.1	Q9V727	59.6	178	1097	1669	1.75e-48	192	ASX_DROME	Polycomb group protein Asx (Protein additional sex combs)	Drosophila melanogaster (Fruit fly)	animal organ morphogenesis [GO:0009887]; antennal development [GO:0007469]; anterior/posterior axis specification [GO:0009948]; apposition of dorsal and ventral imaginal disc-derived wing surfaces [GO:0007475]; cell fate determination [GO:0001709]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; sex comb development [GO:0045498]; syncytial blastoderm mitotic cell cycle [GO:0035186]	chromatin binding [GO:0003682]; deubiquitinase activator activity [GO:0035800]; DNA binding [GO:0003677]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleus [GO:0005634]; PR-DUB complex [GO:0035517]	GO:0000785; GO:0001709; GO:0003677; GO:0003682; GO:0005634; GO:0005694; GO:0006357; GO:0007469; GO:0007475; GO:0009887; GO:0009948; GO:0010468; GO:0035186; GO:0035517; GO:0035800; GO:0040029; GO:0045498; GO:0045892; GO:0045893; GO:0045944
GN013178	GN013178.1	P32929	68.1	47	65	405	1.64e-14	68.9	CGL_HUMAN	Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2)	Homo sapiens (Human)	endoplasmic reticulum unfolded protein response [GO:0030968]; hydrogen sulfide biosynthetic process [GO:0070814]; L-cysteine biosynthetic process [GO:0019344]; negative regulation of apoptotic process [GO:0043066]; positive regulation of aortic smooth muscle cell differentiation [GO:1904831]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; protein homotetramerization [GO:0051289]; protein sulfhydration [GO:0044524]; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine [GO:0018272]; selenium compound metabolic process [GO:0001887]; transsulfuration [GO:0019346]	cystathionine gamma-lyase activity [GO:0004123]; homocysteine desulfhydrase activity [GO:0047982]; identical protein binding [GO:0042802]; L-cysteine desulfhydrase activity [GO:0080146]; L-cystine L-cysteine-lyase (deaminating) activity [GO:0044540]; pyridoxal phosphate binding [GO:0030170]; selenocystathionine gamma-lyase activity [GO:0098606]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0001887; GO:0004123; GO:0005829; GO:0018272; GO:0019344; GO:0019346; GO:0030170; GO:0030968; GO:0042802; GO:0043066; GO:0043123; GO:0044524; GO:0044540; GO:0047982; GO:0051289; GO:0070062; GO:0070814; GO:0080146; GO:0098606; GO:1904831
GN013180	GN013180.1	Q5VVX9	38.3	222	330	321	7.95e-41	148	UBE2U_HUMAN	Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)	Homo sapiens (Human)	DNA repair [GO:0006281]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]	ubiquitin conjugating enzyme activity [GO:0061631]	HULC complex [GO:0033503]	GO:0000209; GO:0006281; GO:0033503; GO:0043161; GO:0061631
GN013182	GN013182.1	P37193	73.6	125	126	172	8.19e-66	199	ADXH1_DROME	Adrenodoxin-like protein 1, mitochondrial (Ferredoxin-1)	Drosophila melanogaster (Fruit fly)	[2Fe-2S] cluster assembly [GO:0044571]; iron-sulfur cluster assembly [GO:0016226]; P450-containing electron transport chain [GO:0140647]; positive regulation of ecdysteroid biosynthetic process [GO:0045998]; ubiquinone biosynthetic process [GO:0006744]	2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0006744; GO:0009055; GO:0016226; GO:0044571; GO:0045998; GO:0051537; GO:0140647
GN013183	GN013183.1	E7F5Q0	42.7	1196	1504	1290	0.0	948	CAHD1_DANRE	VWFA and cache domain-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	cartilage morphogenesis [GO:0060536]	voltage-gated calcium channel activity [GO:0005245]	voltage-gated calcium channel complex [GO:0005891]	GO:0005245; GO:0005891; GO:0060536
GN013187	GN013187.1	Q9TT23	25.3	324	357	325	2.52e-12	70.5	MC5R_PANTR	Melanocortin receptor 5 (MC5-R)	Pan troglodytes (Chimpanzee)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; negative regulation of immune response [GO:0050777]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; temperature homeostasis [GO:0001659]	corticotropin receptor activity [GO:0004978]; melanocortin receptor activity [GO:0004977]; melanocyte-stimulating hormone receptor activity [GO:0004980]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0001659; GO:0004977; GO:0004978; GO:0004980; GO:0005737; GO:0005886; GO:0007189; GO:0045921; GO:0050777; GO:0070374
GN013188	GN013188.1	Q3B7D2	51.8	332	300	560	3.07e-107	325	SPTC2_RAT	Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2)	Rattus norvegicus (Rat)	adipose tissue development [GO:0060612]; ceramide biosynthetic process [GO:0046513]; glycosphingolipid biosynthetic process [GO:0006688]; positive regulation of lipophagy [GO:1904504]; response to immobilization stress [GO:0035902]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512]	pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum membrane [GO:0005789]; serine palmitoyltransferase complex [GO:0017059]	GO:0004758; GO:0005789; GO:0006686; GO:0006688; GO:0017059; GO:0030148; GO:0030170; GO:0035902; GO:0046511; GO:0046512; GO:0046513; GO:0060612; GO:0098554; GO:1904504
GN013189	GN013189.1	Q6V0I7	26.5	3242	3571	4981	1.34e-174	613	FAT4_HUMAN	Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J)	Homo sapiens (Human)	axonogenesis [GO:0007409]; cell-cell adhesion mediated by cadherin [GO:0044331]; cerebral cortex development [GO:0021987]; epithelial cell differentiation [GO:0030855]; heterophilic cell-cell adhesion [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell-cell adhesion [GO:0007156]; neurogenesis [GO:0022008]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005912; GO:0007156; GO:0007157; GO:0007409; GO:0021987; GO:0022008; GO:0030855; GO:0035329; GO:0044331; GO:0070062
GN013190	GN013190.1	Q865S1	58.3	1174	1152	1207	0.0	1191	AP3D1_BOVIN	AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (BLVPCP1) (Bovine leukemia virus cell receptor) (BLV-R) (Delta-adaptin)	Bos taurus (Bovine)	anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; Golgi to vacuole transport [GO:0006896]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; protein targeting to vacuole [GO:0006623]; synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle membrane organization [GO:0048499]		AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; presynaptic endosome [GO:0098830]; terminal bouton [GO:0043195]	GO:0000139; GO:0006623; GO:0006896; GO:0008089; GO:0010008; GO:0016182; GO:0030123; GO:0043195; GO:0048490; GO:0048499; GO:0098830; GO:0098943; GO:1904115
GN013192	GN013192.1	Q12857	46.6	564	737	509	6.46e-104	330	NFIA_HUMAN	Nuclear factor 1 A-type (NF1-A) (Nuclear factor 1/A) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/A) (NF-I/A) (NFI-A) (TGGCA-binding protein)	Homo sapiens (Human)	BMP signaling pathway [GO:0030509]; cartilage development [GO:0051216]; cell morphogenesis [GO:0000902]; limb morphogenesis [GO:0035108]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; viral genome replication [GO:0019079]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000902; GO:0000978; GO:0000981; GO:0001228; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0006355; GO:0006357; GO:0019079; GO:0030509; GO:0035108; GO:0045944; GO:0051216; GO:0140297
GN013193	GN013193.1	Q28CJ6	49.1	277	311	346	2.43e-60	199	NDEL1_XENTR	Nuclear distribution protein nudE-like 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	lysosome localization [GO:0032418]; positive regulation of ruffle assembly [GO:1900029]	microtubule binding [GO:0008017]	centrosome [GO:0005813]; spindle [GO:0005819]	GO:0005813; GO:0005819; GO:0008017; GO:0032418; GO:1900029
GN013194	GN013194.1	Q5ZID2	45.7	184	318	379	9.61e-43	154	PDD2L_CHICK	uS5 assembly chaperone PDCD2L (Programmed cell death protein 2-like)	Gallus gallus (Chicken)	apoptotic process [GO:0006915]		cytosol [GO:0005829]; nucleolus [GO:0005730]	GO:0005730; GO:0005829; GO:0006915
GN013197	GN013197.1	Q8BMF5	33.9	286	538	956	2.68e-35	144	GRIK4_MOUSE	Glutamate receptor ionotropic, kainate 4 (GluK4) (Glutamate receptor KA-1) (KA1)	Mus musculus (Mouse)	modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]	kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; kainate selective glutamate receptor complex [GO:0032983]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; terminal bouton [GO:0043195]	GO:0005886; GO:0015277; GO:0016020; GO:0030424; GO:0030425; GO:0032983; GO:0035249; GO:0042734; GO:0043195; GO:0043204; GO:0045202; GO:0045211; GO:0050804; GO:0098686; GO:0098839; GO:0098978; GO:0099507; GO:1904315
GN013202	GN013202.1	Q9WYJ1	41.5	313	327	401	2.97e-64	211	TSAL_THEMA	L-threonine ammonia-lyase (EC 4.3.1.19) (L-serine ammonia-lyase) (EC 4.3.1.17) (Threonine dehydratase)	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	L-serine catabolic process [GO:0006565]; L-threonine catabolic process [GO:0006567]	L-serine ammonia-lyase activity [GO:0003941]; pyridoxal phosphate binding [GO:0030170]; threonine deaminase activity [GO:0004794]		GO:0003941; GO:0004794; GO:0006565; GO:0006567; GO:0030170
GN013204	GN013204.1	Q8TAT6	70.1	174	236	608	2.61e-92	286	NPL4_HUMAN	Nuclear protein localization protein 4 homolog (Protein NPL4)	Homo sapiens (Human)	ERAD pathway [GO:0036503]; Golgi organization [GO:0007030]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; rescue of stalled cytosolic ribosome [GO:0072344]; retrograde protein transport, ER to cytosol [GO:0030970]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]; ubiquitin-dependent protein catabolic process [GO:0006511]	ATPase binding [GO:0051117]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]	ATPase complex [GO:1904949]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear outer membrane-endoplasmic reticulum membrane network [GO:0042175]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RQC complex [GO:1990112]; UFD1-NPL4 complex [GO:0036501]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	GO:0005634; GO:0005654; GO:0005783; GO:0005829; GO:0006511; GO:0007030; GO:0030970; GO:0031625; GO:0032480; GO:0034098; GO:0036435; GO:0036501; GO:0036503; GO:0039536; GO:0042175; GO:0043130; GO:0043161; GO:0044877; GO:0051117; GO:0070530; GO:0072344; GO:1904949; GO:1990112; GO:1990116
GN013205	GN013205.1	Q96P65	31.4	105	149	431	9.45e-14	70.5	QRFPR_HUMAN	Pyroglutamylated RF-amide peptide receptor (AQ27) (G protein-coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)	Homo sapiens (Human)	cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]	G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0016020; GO:0032870
GN013206	GN013206.1	P30098	32.6	227	287	440	2.26e-26	110	NK3R_CAVPO	Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3)	Cavia porcellus (Guinea pig)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating tachykinin receptor signaling pathway [GO:0007209]; positive regulation of flagellated sperm motility [GO:1902093]	tachykinin receptor activity [GO:0004995]; transmembrane signaling receptor activity [GO:0004888]	plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]	GO:0004888; GO:0004995; GO:0005886; GO:0007166; GO:0007186; GO:0007189; GO:0007209; GO:0097225; GO:1902093
GN013211	GN013211.1	Q99NB2	30.7	166	233	377	2.55e-18	85.9	B3GN5_RAT	Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylglucosaminyltransferase 5) (Beta3Gn-T5)	Rattus norvegicus (Rat)	central nervous system development [GO:0007417]; glycoprotein biosynthetic process [GO:0009101]; sphingolipid biosynthetic process [GO:0030148]	lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity [GO:0047256]	Golgi membrane [GO:0000139]	GO:0000139; GO:0007417; GO:0009101; GO:0030148; GO:0047256
GN013212	GN013212.1	Q6P3P5	32.4	244	398	377	2.64e-33	131	B3GN5_XENTR	Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylglucosaminyltransferase 5) (Beta3Gn-T5)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	glycoprotein biosynthetic process [GO:0009101]; sphingolipid biosynthetic process [GO:0030148]	lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity [GO:0047256]	Golgi membrane [GO:0000139]	GO:0000139; GO:0009101; GO:0030148; GO:0047256
GN013213	GN013213.1	P29540	51.2	287	285	288	2.33e-92	278	T2EB_XENLA	General transcription factor IIE subunit 2 (Transcription initiation factor IIE subunit beta) (TFIIE-beta)	Xenopus laevis (African clawed frog)	transcription initiation at RNA polymerase II promoter [GO:0006367]	RNA polymerase II general transcription initiation factor activity [GO:0016251]; TFIIH-class transcription factor complex binding [GO:0001097]	transcription factor TFIIE complex [GO:0005673]	GO:0001097; GO:0005673; GO:0006367; GO:0016251
GN013214	GN013214.1	Q55FI1	53.0	283	287	495	9.61e-104	314	GABT_DICDI	4-aminobutyrate aminotransferase (EC 2.6.1.19) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase)	Dictyostelium discoideum (Social amoeba)	GABA catabolic process [GO:0009450]	4-aminobutyrate:2-oxoglutarate transaminase activity [GO:0034386]; pyridoxal phosphate binding [GO:0030170]	4-aminobutyrate transaminase complex [GO:0032144]; mitochondrion [GO:0005739]	GO:0005739; GO:0009450; GO:0030170; GO:0032144; GO:0034386
GN013215	GN013215.1	Q62920	31.8	610	593	591	1.04e-70	241	PDLI5_RAT	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)	Rattus norvegicus (Rat)	actin cytoskeleton organization [GO:0030036]; cell growth involved in cardiac muscle cell development [GO:0061049]; heart development [GO:0007507]; muscle structure development [GO:0061061]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of postsynapse assembly [GO:0150052]; regulation of synapse assembly [GO:0051963]	actin binding [GO:0003779]; actinin binding [GO:0042805]; muscle alpha-actinin binding [GO:0051371]; protein kinase C binding [GO:0005080]; signaling receptor complex adaptor activity [GO:0030159]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; stress fiber [GO:0001725]; Z disc [GO:0030018]	GO:0001725; GO:0003779; GO:0005080; GO:0005737; GO:0005829; GO:0005912; GO:0007507; GO:0014069; GO:0015629; GO:0016020; GO:0030018; GO:0030036; GO:0030159; GO:0031941; GO:0042805; GO:0051371; GO:0051963; GO:0061001; GO:0061049; GO:0061061; GO:0098793; GO:0098794; GO:0098978; GO:0150052
GN013216	GN013216.1	A1ZA47	33.2	394	379	2194	1.61e-46	174	ZASP_DROME	PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein)	Drosophila melanogaster (Fruit fly)	actin cytoskeleton organization [GO:0030036]; muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; regulation of cell-matrix adhesion [GO:0001952]	actin binding [GO:0003779]; actinin binding [GO:0042805]; muscle alpha-actinin binding [GO:0051371]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; apical part of cell [GO:0045177]; basal part of cell [GO:0045178]; basolateral plasma membrane [GO:0016323]; cell leading edge [GO:0031252]; filamentous actin [GO:0031941]; focal adhesion [GO:0005925]; muscle tendon junction [GO:0005927]; stress fiber [GO:0001725]; Z disc [GO:0030018]; zonula adherens [GO:0005915]	GO:0001725; GO:0001952; GO:0003779; GO:0005912; GO:0005915; GO:0005925; GO:0005927; GO:0015629; GO:0016323; GO:0030018; GO:0030036; GO:0030239; GO:0031252; GO:0031941; GO:0042805; GO:0045177; GO:0045178; GO:0051371; GO:0061061
GN013218	GN013218.1	P00761	48.4	157	157	231	5.81e-48	157	TRYP_PIG	Trypsin (EC 3.4.21.4)	Sus scrofa (Pig)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]	GO:0004252; GO:0005576; GO:0006508
GN013219	GN013219.1	Q9NH13	30.7	361	478	421	2.22e-51	182	RP43_RIFPA	Exoskeleton protein RP43	Riftia pachyptila (Vent tube worm)	chitin localization [GO:0006033]; extracellular matrix organization [GO:0030198]			GO:0006033; GO:0030198
GN013221	GN013221.1	Q504A5	44.4	216	244	232	2.45e-60	192	TPMT_DANRE	Probable thiopurine S-methyltransferase (Thiopurine methyltransferase) (EC 2.1.1.67)	Danio rerio (Zebrafish) (Brachydanio rerio)		thiopurine S-methyltransferase activity [GO:0008119]	cytoplasm [GO:0005737]	GO:0005737; GO:0008119
GN013222	GN013222.1	Q5XGS8	73.0	525	606	654	2.90e-273	764	GTPB1_XENLA	GTP-binding protein 1 (EC 3.6.5.3)	Xenopus laevis (African clawed frog)	GTP metabolic process [GO:0046039]; positive regulation of mRNA catabolic process [GO:0061014]; RNA surveillance [GO:0071025]; translational elongation [GO:0006414]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]	GO:0000049; GO:0000177; GO:0003746; GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0006414; GO:0046039; GO:0061014; GO:0071025
GN013223	GN013223.1	Q17045	56.9	72	118	591	1.17e-17	80.5	AGP1_ASCSU	GTP-binding protein AGP-1	Ascaris suum (Pig roundworm) (Ascaris lumbricoides)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]		GO:0003746; GO:0003924; GO:0005525
GN013224	GN013224.1	Q5XGS8	74.6	452	478	654	3.41e-238	670	GTPB1_XENLA	GTP-binding protein 1 (EC 3.6.5.3)	Xenopus laevis (African clawed frog)	GTP metabolic process [GO:0046039]; positive regulation of mRNA catabolic process [GO:0061014]; RNA surveillance [GO:0071025]; translational elongation [GO:0006414]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]	GO:0000049; GO:0000177; GO:0003746; GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0006414; GO:0046039; GO:0061014; GO:0071025
GN013225	GN013225.1	Q5BK24	28.1	310	284	374	4.55e-24	103	CH076_RAT	Uncharacterized protein C8orf76 homolog	Rattus norvegicus (Rat)				
GN013226	GN013226.1	Q8K2L8	48.3	445	797	797	2.01e-134	421	TPC12_MOUSE	Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15)	Mus musculus (Mouse)	COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; metaphase chromosome alignment [GO:0051310]; positive regulation of protein localization to kinetochore [GO:1905342]; regulation of kinetochore assembly [GO:0090234]; vesicle tethering [GO:0099022]		cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072]	GO:0000776; GO:0005634; GO:0005654; GO:0005737; GO:0005793; GO:0005794; GO:0006888; GO:0007030; GO:0030008; GO:0048208; GO:0048471; GO:0051310; GO:0090234; GO:0099022; GO:1905342; GO:1990072
GN013227	GN013227.1	Q9NV79	63.7	262	583	361	5.40e-116	352	PCMD2_HUMAN	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2	Homo sapiens (Human)		protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719]	cytoplasm [GO:0005737]	GO:0004719; GO:0005737
GN013229	GN013229.1	Q8CFW7	44.2	1501	1736	1633	0.0	1124	C2D2A_MOUSE	Coiled-coil and C2 domain-containing protein 2A	Mus musculus (Mouse)	axoneme assembly [GO:0035082]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; heart development [GO:0007507]; kidney development [GO:0001822]; motile cilium assembly [GO:0044458]; neural tube closure [GO:0001843]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]; smoothened signaling pathway [GO:0007224]		ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; MKS complex [GO:0036038]	GO:0001822; GO:0001843; GO:0005737; GO:0007224; GO:0007368; GO:0007507; GO:0035082; GO:0035869; GO:0036038; GO:0043010; GO:0044458; GO:0060271; GO:1904491; GO:1905515; GO:1990403
GN013230	GN013230.1	O42222	31.1	209	291	374	3.16e-28	114	GDF8_DANRE	Growth/differentiation factor 8 (GDF-8) (Myostatin) (Myostatin-1) (zfMSTN-1) (Myostatin-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	cardiac muscle myoblast proliferation [GO:0110021]; immune response [GO:0006955]; muscle organ development [GO:0007517]; negative regulation of cardiac muscle myoblast proliferation [GO:0110023]; negative regulation of growth [GO:0045926]; negative regulation of growth rate [GO:0045967]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of striated muscle tissue development [GO:0045843]; regulation of muscle hyperplasia [GO:0014738]; skeletal muscle tissue development [GO:0007519]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular trabecula myocardium morphogenesis [GO:0003222]	cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0003222; GO:0005102; GO:0005125; GO:0005576; GO:0006955; GO:0007179; GO:0007517; GO:0007519; GO:0008083; GO:0014738; GO:0045843; GO:0045926; GO:0045967; GO:0048642; GO:0110021; GO:0110023
GN013233	GN013233.1	Q8R3G1	54.9	339	330	351	3.66e-113	335	PP1R8_MOUSE	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8)	Mus musculus (Mouse)	cell population proliferation [GO:0008283]	molecular function inhibitor activity [GO:0140678]; mRNA binding [GO:0003729]; protein phosphatase regulator activity [GO:0019888]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; RNA endonuclease activity [GO:0004521]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	GO:0003729; GO:0004521; GO:0004865; GO:0005654; GO:0008283; GO:0016607; GO:0019888; GO:0140678
GN013234	GN013234.1	Q5FW38	47.8	69	201	462	1.95e-09	59.7	NFIL3_XENTR	Nuclear factor interleukin-3-regulated protein	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	circadian rhythm [GO:0007623]; immune response [GO:0006955]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0006355; GO:0006366; GO:0006955; GO:0007623; GO:0045892
GN013236	GN013236.1	Q7RTU0	70.0	90	178	167	1.92e-32	117	TCF24_HUMAN	Transcription factor 24 (TCF-24)	Homo sapiens (Human)	developmental process [GO:0032502]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0032502; GO:0046983
GN013237	GN013237.1	Q32PV5	73.5	83	111	176	4.52e-33	116	TCF21_DANRE	Transcription factor 21 (TCF-21) (Capsulin) (Epicardin) (MyoRa2)	Danio rerio (Zebrafish) (Brachydanio rerio)	artery development [GO:0060840]; branching involved in ureteric bud morphogenesis [GO:0001658]; branchiomeric skeletal muscle development [GO:0014707]; bronchiole development [GO:0060435]; developmental process [GO:0032502]; diaphragm development [GO:0060539]; embryonic digestive tract morphogenesis [GO:0048557]; epithelial cell differentiation [GO:0030855]; gland development [GO:0048732]; glomerulus development [GO:0032835]; kidney development [GO:0001822]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; lung vasculature development [GO:0060426]; metanephric glomerular capillary formation [GO:0072277]; metanephric mesenchymal cell differentiation [GO:0072162]; morphogenesis of a branching structure [GO:0001763]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; reproductive structure development [GO:0048608]; respiratory system development [GO:0060541]; roof of mouth development [GO:0060021]; Sertoli cell differentiation [GO:0060008]; sex determination [GO:0007530]; skeletal muscle tissue development [GO:0007519]; spleen development [GO:0048536]; ureteric bud development [GO:0001657]; vasculature development [GO:0001944]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000122; GO:0000977; GO:0000981; GO:0001227; GO:0001228; GO:0001657; GO:0001658; GO:0001763; GO:0001822; GO:0001944; GO:0005634; GO:0006357; GO:0007519; GO:0007530; GO:0014707; GO:0030855; GO:0032502; GO:0032835; GO:0045944; GO:0046983; GO:0048286; GO:0048536; GO:0048557; GO:0048608; GO:0048732; GO:0060008; GO:0060021; GO:0060425; GO:0060426; GO:0060435; GO:0060539; GO:0060541; GO:0060766; GO:0060840; GO:0070888; GO:0072162; GO:0072277
GN013239	GN013239.1	B0V0U5	24.9	839	1290	1495	2.59e-40	167	URB2_DANRE	Unhealthy ribosome biogenesis protein 2 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosome biogenesis [GO:0042254]		nucleolus [GO:0005730]	GO:0005730; GO:0042254; GO:1901796; GO:1902036
GN013244	GN013244.1	Q5BLX8	62.1	277	290	315	1.65e-79	246	WDR83_RAT	WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1)	Rattus norvegicus (Rat)	inflammatory response to wounding [GO:0090594]; mRNA splicing, via spliceosome [GO:0000398]; neural tube closure [GO:0001843]; placenta blood vessel development [GO:0060674]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; RNA splicing, via transesterification reactions [GO:0000375]		catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; lysosome [GO:0005764]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	GO:0000375; GO:0000398; GO:0001666; GO:0001843; GO:0005634; GO:0005681; GO:0005737; GO:0005764; GO:0009611; GO:0032496; GO:0043122; GO:0060674; GO:0071013; GO:0090594
GN013247	GN013247.1	Q9V6K3	46.6	509	466	724	2.38e-153	456	ROR2_DROME	Tyrosine-protein kinase transmembrane receptor Ror2 (dRor2) (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase)	Drosophila melanogaster (Fruit fly)	cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; muscle cell cellular homeostasis [GO:0046716]; photoreceptor cell axon guidance [GO:0072499]; rhabdomere development [GO:0042052]; signal transduction [GO:0007165]	ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; Wnt-protein binding [GO:0017147]	plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004713; GO:0004714; GO:0005524; GO:0005886; GO:0007165; GO:0007169; GO:0017147; GO:0042052; GO:0043235; GO:0046716; GO:0072499
GN013248	GN013248.1	Q2NKS3	40.2	102	134	122	2.09e-18	78.2	PSMG3_BOVIN	Proteasome assembly chaperone 3	Bos taurus (Bovine)	chaperone-mediated protein complex assembly [GO:0051131]; proteasome assembly [GO:0043248]	molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]	protein folding chaperone complex [GO:0101031]	GO:0043248; GO:0044877; GO:0051131; GO:0060090; GO:0101031
GN013249	GN013249.1	Q68FJ6	40.6	325	391	363	2.00e-86	269	PK1IP_XENLA	p21-activated protein kinase-interacting protein 1-like (PAK1-interacting protein 1-like)	Xenopus laevis (African clawed frog)	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; ribosomal large subunit biogenesis [GO:0042273]	protein kinase inhibitor activity [GO:0004860]	nucleolus [GO:0005730]	GO:0000463; GO:0004860; GO:0005730; GO:0042273
GN013250	GN013250.1	Q80VC6	57.2	173	261	287	6.73e-67	212	TSAP1_MOUSE	tRNA selenocysteine 1-associated protein 1 (SECp43) (tRNA selenocysteine-associated protein 1)	Mus musculus (Mouse)	selenocysteine incorporation [GO:0001514]	tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000049; GO:0001514; GO:0005634; GO:0005737
GN013251	GN013251.1	Q9NX55	62.2	98	117	121	9.67e-33	114	HYPK_HUMAN	Huntingtin-interacting protein K (Huntingtin yeast partner K)	Homo sapiens (Human)	negative regulation of apoptotic process [GO:0043066]; protein stabilization [GO:0050821]	protein folding chaperone [GO:0044183]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0005634; GO:0005654; GO:0005737; GO:0032991; GO:0043066; GO:0044183; GO:0050821
GN013252	GN013252.1	B0DOB4	37.1	1479	1439	1430	9.74e-301	894	NPHP4_XENLA	Nephrocystin-4	Xenopus laevis (African clawed frog)	negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein localization to ciliary transition zone [GO:1904491]		ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; non-motile cilium [GO:0097730]	GO:0035869; GO:0036064; GO:0090090; GO:0097546; GO:0097730; GO:1904491
GN013256	GN013256.1	Q9LDD8	47.8	510	561	587	5.22e-148	441	MCCB_ARATH	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)	Arabidopsis thaliana (Mouse-ear cress)	L-leucine catabolic process [GO:0006552]	cobalt ion binding [GO:0050897]; methylcrotonoyl-CoA carboxylase activity [GO:0004485]; zinc ion binding [GO:0008270]	methylcrotonoyl-CoA carboxylase complex [GO:1905202]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0004485; GO:0005739; GO:0005759; GO:0005886; GO:0006552; GO:0008270; GO:0050897; GO:1905202
GN013257	GN013257.1	Q9NPF5	52.7	480	476	467	6.07e-153	446	DMAP1_HUMAN	DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein import into nucleus [GO:0042307]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; response to ethanol [GO:0045471]	RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000786; GO:0003714; GO:0005634; GO:0005654; GO:0005657; GO:0005737; GO:0005829; GO:0006281; GO:0006338; GO:0006355; GO:0035267; GO:0042307; GO:0042981; GO:0045471; GO:0045892; GO:0045893; GO:0051726; GO:0061629; GO:1905168; GO:2000779
GN013258	GN013258.1	A2VDD2	36.4	162	226	176	6.94e-26	102	DYL5B_XENLA	Dynein light chain Tctex-type 5-B (Tctex1 domain-containing protein 1-B)	Xenopus laevis (African clawed frog)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505
GN013259	GN013259.1	Q9D5I4	34.7	118	191	173	2.06e-15	73.6	DYLT5_MOUSE	Dynein light chain Tctex-type 5 (Tctex1 domain-containing protein 1)	Mus musculus (Mouse)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505
GN013260	GN013260.1	P41340	97.1	376	376	376	2.13e-273	743	ACT3_LIMPO	Actin-3 (EC 3.6.4.-)	Limulus polyphemus (Atlantic horseshoe crab)	anatomical structure formation involved in morphogenesis [GO:0048646]; cell development [GO:0048468]	ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887; GO:0048468; GO:0048646
GN013261	GN013261.1	Q3ZCD7	57.6	304	339	308	6.61e-128	371	TECR_BOVIN	Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)	Bos taurus (Bovine)	fatty acid elongation [GO:0030497]; sphingolipid metabolic process [GO:0006665]; very long-chain fatty acid biosynthetic process [GO:0042761]	trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166]; very-long-chain enoyl-CoA reductase activity [GO:0102758]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0006665; GO:0019166; GO:0030497; GO:0042761; GO:0102758
GN013262	GN013262.1	Q9NUR3	39.7	78	143	256	1.01e-09	58.2	TM74B_HUMAN	Transmembrane protein 74B	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN013264	GN013264.1	Q05722	30.9	165	951	921	9.30e-20	99.0	CO9A1_MOUSE	Collagen alpha-1(IX) chain	Mus musculus (Mouse)	bone morphogenesis [GO:0060349]; cartilage development [GO:0051216]; chondrocyte proliferation [GO:0035988]; extracellular matrix organization [GO:0030198]; growth plate cartilage development [GO:0003417]; skeletal system development [GO:0001501]; tissue homeostasis [GO:0001894]	carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein homodimerization activity [GO:0042803]	collagen type IX trimer [GO:0005594]; extracellular matrix [GO:0031012]	GO:0001501; GO:0001894; GO:0003417; GO:0005594; GO:0030020; GO:0030198; GO:0030246; GO:0031012; GO:0035988; GO:0042803; GO:0051216; GO:0060349
GN013265	GN013265.1	Q6DHN0	34.0	288	293	281	1.41e-42	150	TMM53_DANRE	Transmembrane protein 53	Danio rerio (Zebrafish) (Brachydanio rerio)	negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; regulation of nucleocytoplasmic transport [GO:0046822]		nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]	GO:0005640; GO:0030279; GO:0030514; GO:0031965; GO:0045668; GO:0046822
GN013268	GN013268.1	Q96T60	44.6	352	417	521	5.98e-94	295	PNKP_HUMAN	Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]	Homo sapiens (Human)	base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via nonhomologous end joining [GO:0006303]; nucleotide-excision repair [GO:0006289]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of telomere maintenance [GO:0032206]; regulation of DNA repair [GO:0006282]; response to oxidative stress [GO:0006979]; response to radiation [GO:0009314]; single strand break repair [GO:0000012]	ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; damaged DNA binding [GO:0003684]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; polynucleotide 3'-phosphatase activity [GO:0046403]; purine nucleotide binding [GO:0017076]	chromosome [GO:0005694]; DNA ligase III-XRCC1 complex [GO:0070421]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]	GO:0000012; GO:0003684; GO:0003690; GO:0004519; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0006261; GO:0006281; GO:0006282; GO:0006284; GO:0006287; GO:0006289; GO:0006303; GO:0006979; GO:0009314; GO:0016020; GO:0017076; GO:0032206; GO:0035861; GO:0046403; GO:0046404; GO:0070421; GO:0090734; GO:2001034
GN013269	GN013269.1	Q17103	33.8	397	369	407	6.66e-34	132	MYC_ASTRU	Myc protein (c-myc)	Asterias rubens (Common European starfish) (Asterias vulgaris)		DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]	nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0046983
GN013270	GN013270.1	Q9H3H1	41.2	456	485	467	6.64e-117	354	MOD5_HUMAN	tRNA dimethylallyltransferase (EC 2.5.1.75) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (hGRO1) (tRNA isopentenyltransferase 1) (IPTase)	Homo sapiens (Human)	mitochondrial tRNA modification [GO:0070900]; tRNA modification [GO:0006400]	ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]; tRNA dimethylallyltransferase activity [GO:0052381]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003676; GO:0005524; GO:0005739; GO:0005759; GO:0006400; GO:0008270; GO:0052381; GO:0070900
GN013271	GN013271.1	Q2KIX1	35.9	103	143	159	3.78e-17	76.3	GA45G_BOVIN	Growth arrest and DNA damage-inducible protein GADD45 gamma	Bos taurus (Bovine)	positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of cell cycle [GO:0051726]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0046330; GO:0051726; GO:1900745
GN013272	GN013272.1	Q3ZBN6	32.9	152	147	165	1.13e-18	80.5	GA45A_BOVIN	Growth arrest and DNA damage-inducible protein GADD45 alpha	Bos taurus (Bovine)	cellular response to ionizing radiation [GO:0071479]; cellular response to mechanical stimulus [GO:0071260]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of cell cycle [GO:0051726]; signal transduction in response to DNA damage [GO:0042770]	kinase binding [GO:0019900]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0000122; GO:0005634; GO:0005737; GO:0016607; GO:0019900; GO:0042770; GO:0042803; GO:0043065; GO:0043537; GO:0046330; GO:0046982; GO:0051726; GO:0071260; GO:0071479; GO:1900745; GO:2000379
GN013273	GN013273.1	P10984	97.1	376	376	376	9.07e-275	747	ACT2_CAEEL	Actin-2 (EC 3.6.4.-)	Caenorhabditis elegans	cortical actin cytoskeleton organization [GO:0030866]; embryo development ending in birth or egg hatching [GO:0009792]; locomotion [GO:0040011]; meiosis II cytokinesis [GO:0007111]; mitotic cytokinesis [GO:0000281]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]	GO:0000281; GO:0005200; GO:0005524; GO:0005737; GO:0005884; GO:0005938; GO:0007111; GO:0009792; GO:0015629; GO:0016887; GO:0030866; GO:0040011
GN013274	GN013274.1	O17320	99.5	376	376	376	4.02e-278	755	ACT_MAGGI	Actin (EC 3.6.4.-)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN013275	GN013275.1	Q25010	97.6	376	376	376	2.60e-274	746	ACT3A_HELAM	Actin, cytoplasmic A3a (EC 3.6.4.-)	Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)	anatomical structure formation involved in morphogenesis [GO:0048646]; cell development [GO:0048468]	ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887; GO:0048468; GO:0048646
GN013276	GN013276.1	O17320	97.1	376	376	376	2.60e-274	746	ACT_MAGGI	Actin (EC 3.6.4.-)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN013277	GN013277.1	Q25010	92.1	329	329	376	7.29e-223	613	ACT3A_HELAM	Actin, cytoplasmic A3a (EC 3.6.4.-)	Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)	anatomical structure formation involved in morphogenesis [GO:0048646]; cell development [GO:0048468]	ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887; GO:0048468; GO:0048646
GN013281	GN013281.1	P12716	97.6	376	376	376	1.83e-274	746	ACTC_PISOC	Actin, cytoplasmic (EC 3.6.4.-) [Cleaved into: Actin, cytoplasmic, intermediate form]	Pisaster ochraceus (Ochre sea star) (Asterias ochracea)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN013282	GN013282.1	P79818	81.4	376	377	375	4.99e-224	619	ACTB_ORYLA	Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) (OlCA1) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]	Oryzias latipes (Japanese rice fish) (Japanese killifish)		ATP hydrolysis activity [GO:0016887]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; dense body [GO:0097433]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005200; GO:0005634; GO:0005856; GO:0005886; GO:0005925; GO:0015629; GO:0016887; GO:0097433
GN013283	GN013283.1	O17320	81.2	308	318	376	1.74e-181	508	ACT_MAGGI	Actin (EC 3.6.4.-)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN013285	GN013285.1	P79818	97.6	374	376	375	1.51e-275	749	ACTB_ORYLA	Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) (OlCA1) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]	Oryzias latipes (Japanese rice fish) (Japanese killifish)		ATP hydrolysis activity [GO:0016887]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; dense body [GO:0097433]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005200; GO:0005634; GO:0005856; GO:0005886; GO:0005925; GO:0015629; GO:0016887; GO:0097433
GN013286	GN013286.1	Q13351	81.0	100	375	362	1.90e-22	100	KLF1_HUMAN	Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF)	Homo sapiens (Human)	cellular response to endothelin [GO:1990859]; erythrocyte differentiation [GO:0030218]; maternal process involved in female pregnancy [GO:0060135]; positive regulation of DNA-templated transcription [GO:0045893]; protein destabilization [GO:0031648]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; ubiquitin-dependent protein catabolic process [GO:0006511]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin binding [GO:0043130]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000976; GO:0000978; GO:0000981; GO:0003700; GO:0005634; GO:0005654; GO:0006355; GO:0006357; GO:0006511; GO:0030218; GO:0031648; GO:0043130; GO:0045893; GO:0060135; GO:1990859
GN013287	GN013287.1	Q66IC8	33.3	120	211	173	1.20e-15	74.7	DYLT5_DANRE	Dynein light chain Tctex-type 5 (Tctex1 domain-containing protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505; GO:0060271
GN013288	GN013288.1	Q8N7M0	38.5	117	210	179	3.00e-19	84.3	DYLT5_HUMAN	Dynein light chain Tctex-type 5 (Tctex1 domain-containing protein 1)	Homo sapiens (Human)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505
GN013289	GN013289.1	Q66IC8	41.7	120	200	173	3.10e-26	102	DYLT5_DANRE	Dynein light chain Tctex-type 5 (Tctex1 domain-containing protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505; GO:0060271
GN013290	GN013290.1	O95881	55.3	114	119	172	5.98e-40	134	TXD12_HUMAN	Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19)	Homo sapiens (Human)	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]	protein-disulfide reductase (glutathione) activity [GO:0019153]; protein-disulfide reductase activity [GO:0015035]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	GO:0005783; GO:0005788; GO:0015035; GO:0019153; GO:1902236
GN013293	GN013293.1	Q8C753	52.6	610	598	1610	7.71e-206	622	KATIP_MOUSE	Katanin-interacting protein	Mus musculus (Mouse)	cerebrospinal fluid circulation [GO:0090660]		axoneme [GO:0005930]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0005576; GO:0005654; GO:0005886; GO:0005929; GO:0005930; GO:0034451; GO:0036064; GO:0090660
GN013298	GN013298.1	Q7Z6J9	31.8	559	572	526	2.00e-57	204	SEN54_HUMAN	tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54)	Homo sapiens (Human)	tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]; tRNA-type intron splice site recognition and cleavage [GO:0000379]		nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; tRNA-intron endonuclease complex [GO:0000214]	GO:0000214; GO:0000379; GO:0005654; GO:0005730; GO:0006388
GN013299	GN013299.1	Q5RBL0	50.4	228	303	306	2.68e-71	225	YIPF1_PONAB	Protein YIPF1 (YIP1 family member 1)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	vesicle-mediated transport [GO:0016192]	small GTPase binding [GO:0031267]	Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; late endosome membrane [GO:0031902]; trans-Golgi network [GO:0005802]	GO:0000138; GO:0005797; GO:0005802; GO:0016192; GO:0031267; GO:0031902
GN013304	GN013304.1	P08953	40.6	170	1186	1097	2.82e-24	114	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN013311	GN013311.1	Q80ZJ1	33.9	171	203	183	2.55e-28	107	RAP2A_MOUSE	Ras-related protein Rap-2a (EC 3.6.5.2)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; establishment of protein localization [GO:0045184]; intracellular protein localization [GO:0008104]; negative regulation of cell migration [GO:0030336]; positive regulation of cell migration [GO:0030335]; positive regulation of microvillus assembly [GO:1903698]; positive regulation of protein autophosphorylation [GO:0031954]; Rap protein signal transduction [GO:0032486]; regulation of dendrite morphogenesis [GO:0048814]; regulation of JNK cascade [GO:0046328]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of synapse assembly [GO:0051963]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; endolysosome [GO:0036019]; Golgi apparatus [GO:0005794]; lamellipodium membrane [GO:0031258]; lysosome [GO:0005764]; membrane [GO:0016020]; midbody [GO:0030496]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0000287; GO:0003924; GO:0003925; GO:0005525; GO:0005764; GO:0005794; GO:0005829; GO:0005886; GO:0008104; GO:0016020; GO:0019003; GO:0030036; GO:0030335; GO:0030336; GO:0030496; GO:0031258; GO:0031954; GO:0032486; GO:0036019; GO:0045184; GO:0045202; GO:0046328; GO:0048814; GO:0051963; GO:0055037; GO:0055038; GO:0097060; GO:0098685; GO:0099072; GO:1903698
GN013312	GN013312.1	Q02338	37.0	303	369	343	3.02e-61	203	BDH_HUMAN	D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH) (Short chain dehydrogenase/reductase family 9C member 1)	Homo sapiens (Human)	ketone biosynthetic process [GO:0042181]; ketone catabolic process [GO:0042182]	3-hydroxybutyrate dehydrogenase activity [GO:0003858]	matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003858; GO:0005739; GO:0005743; GO:0005759; GO:0042181; GO:0042182; GO:0099617
GN013313	GN013313.1	U3JAG9	44.0	895	1171	1113	5.47e-138	450	CP131_DANRE	Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium assembly [GO:0035735]; Kupffer's vesicle development [GO:0070121]; melanosome transport [GO:0032402]; negative regulation of intracellular protein transport [GO:0090317]; regulation of centrosome duplication [GO:0010824]; sensory perception of light stimulus [GO:0050953]		acrosomal vesicle [GO:0001669]; centriolar satellite [GO:0034451]; chromosome, centromeric region [GO:0000775]; cilium [GO:0005929]; extracellular region [GO:0005576]	GO:0000775; GO:0001669; GO:0005576; GO:0005929; GO:0010824; GO:0032402; GO:0034451; GO:0035721; GO:0035735; GO:0050953; GO:0060271; GO:0060287; GO:0070121; GO:0090317
GN013314	GN013314.1	Q8K0V4	48.4	810	756	751	2.04e-198	583	CNOT3_MOUSE	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3)	Mus musculus (Mouse)	determination of left/right symmetry [GO:0007368]; gene expression [GO:0010467]; mRNA catabolic process [GO:0006402]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of DNA-templated transcription [GO:0006355]; regulation of stem cell population maintenance [GO:2000036]; trophectodermal cell differentiation [GO:0001829]		CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]	GO:0000289; GO:0000932; GO:0001829; GO:0005634; GO:0005829; GO:0006355; GO:0006402; GO:0007368; GO:0010467; GO:0030014; GO:0030015; GO:0033147; GO:0120162; GO:2000036
GN013315	GN013315.1	Q8HY87	30.7	466	560	826	2.42e-55	203	RNZ2_MACFA	Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	mitochondrial tRNA 3'-end processing [GO:1990180]	3'-tRNA processing endoribonuclease activity [GO:0042781]	mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005739; GO:0042645; GO:0042781; GO:1990180
GN013322	GN013322.1	B8A5Y1	30.0	477	434	502	2.23e-43	162	ZN488_DANRE	Zinc finger protein 488 (EC 2.1.1.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of DNA-templated transcription [GO:0006355]; spinal cord motor neuron cell fate specification [GO:0021520]		nucleus [GO:0005634]	GO:0005634; GO:0006355; GO:0021520
GN013327	GN013327.1	Q92113	35.2	477	498	509	6.74e-87	279	CP17A_SQUAC	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)	Squalus acanthias (Spiny dogfish)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid biosynthetic process [GO:0006694]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	membrane [GO:0016020]	GO:0004508; GO:0005506; GO:0006694; GO:0016020; GO:0020037; GO:0042446; GO:0042448
GN013328	GN013328.1	P30437	33.7	205	224	514	7.68e-32	124	CP17A_ONCMY	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)	Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid biosynthetic process [GO:0006694]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	membrane [GO:0016020]	GO:0004508; GO:0005506; GO:0006694; GO:0016020; GO:0020037; GO:0042446; GO:0042448
GN013329	GN013329.1	Q3UMF9	39.2	240	253	409	1.06e-51	176	FAXC_MOUSE	Failed axon connections homolog	Mus musculus (Mouse)			membrane [GO:0016020]	GO:0016020
GN013330	GN013330.1	C3ZQF9	41.7	96	143	380	3.05e-15	74.3	QRFPR_BRAFL	QRFP-like peptide receptor	Branchiostoma floridae (Florida lancelet) (Amphioxus)	cellular response to hormone stimulus [GO:0032870]; cellular response to peptide [GO:1901653]; G protein-coupled receptor signaling pathway [GO:0007186]	G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]	plasma membrane [GO:0005886]	GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0032870; GO:1901653
GN013333	GN013333.1	Q924K2	43.1	555	556	649	4.70e-134	407	FAF1_RAT	FAS-associated factor 1	Rattus norvegicus (Rat)	ERAD pathway [GO:0036503]; Fas signaling pathway [GO:0036337]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of DNA replication [GO:0045740]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of protein catabolic process [GO:0045732]; regulation of cell adhesion [GO:0030155]; regulation of protein catabolic process [GO:0042176]	heat shock protein binding [GO:0031072]; NF-kappaB binding [GO:0051059]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	GO:0005634; GO:0005635; GO:0005654; GO:0005737; GO:0005829; GO:0019901; GO:0019904; GO:0030155; GO:0031072; GO:0031625; GO:0034098; GO:0036337; GO:0036503; GO:0042176; GO:0043124; GO:0043130; GO:0045732; GO:0045740; GO:0048471; GO:0051059; GO:1902043
GN013334	GN013334.1	Q924K2	43.1	555	556	649	4.70e-134	407	FAF1_RAT	FAS-associated factor 1	Rattus norvegicus (Rat)	ERAD pathway [GO:0036503]; Fas signaling pathway [GO:0036337]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of DNA replication [GO:0045740]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of protein catabolic process [GO:0045732]; regulation of cell adhesion [GO:0030155]; regulation of protein catabolic process [GO:0042176]	heat shock protein binding [GO:0031072]; NF-kappaB binding [GO:0051059]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	GO:0005634; GO:0005635; GO:0005654; GO:0005737; GO:0005829; GO:0019901; GO:0019904; GO:0030155; GO:0031072; GO:0031625; GO:0034098; GO:0036337; GO:0036503; GO:0042176; GO:0043124; GO:0043130; GO:0045732; GO:0045740; GO:0048471; GO:0051059; GO:1902043
GN013339	GN013339.1	O08653	25.5	588	590	2629	3.68e-29	127	TEP1_RAT	Telomerase protein component 1 (rTLP1) (Telomerase-associated protein 1) (Telomerase protein 1) (p230) (p240) (p80 telomerase homolog)	Rattus norvegicus (Rat)	RNA-templated DNA biosynthetic process [GO:0006278]; telomere maintenance via recombination [GO:0000722]	enzyme binding [GO:0019899]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; ribonucleoprotein complex [GO:1990904]; telomerase holoenzyme complex [GO:0005697]	GO:0000722; GO:0000781; GO:0002039; GO:0003723; GO:0005697; GO:0005737; GO:0006278; GO:0016363; GO:0019899; GO:0070034; GO:1990904
GN013341	GN013341.1	Q501S4	34.1	132	197	254	9.42e-18	81.6	CSKMT_DANRE	Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial (CS-KMT) (EC 2.1.1.-) (Methyltransferase-like protein 12, mitochondrial)	Danio rerio (Zebrafish) (Brachydanio rerio)	peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; peptidyl-lysine trimethylation [GO:0018023]	lysine N-methyltransferase activity [GO:0016278]; protein-lysine N-methyltransferase activity [GO:0016279]	mitochondrion [GO:0005739]	GO:0005739; GO:0016278; GO:0016279; GO:0018023; GO:0018026; GO:0018027
GN013355	GN013355.1	Q9VAF5	26.5	324	650	1706	3.96e-14	80.1	CAD99_DROME	Cadherin-99C	Drosophila melanogaster (Fruit fly)	apical protein localization [GO:0045176]; axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion [GO:0016339]; calcium-mediated signaling [GO:0019722]; cell-cell adhesion mediated by cadherin [GO:0044331]; chorion-containing eggshell formation [GO:0007304]; epithelial cell differentiation [GO:0030855]; follicle cell microvillus organization [GO:0032529]; homophilic cell-cell adhesion [GO:0007156]; mucosal immune response [GO:0002385]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; regulation of follicle cell microvillus length [GO:0032533]; sensory perception of sound [GO:0007605]; tube morphogenesis [GO:0035239]; vitelline membrane formation involved in chorion-containing eggshell formation [GO:0007305]	calcium ion binding [GO:0005509]; myosin binding [GO:0017022]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; endosome membrane [GO:0010008]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	GO:0002385; GO:0005509; GO:0005886; GO:0005902; GO:0005912; GO:0007156; GO:0007304; GO:0007305; GO:0007409; GO:0007605; GO:0010008; GO:0016324; GO:0016339; GO:0017022; GO:0019722; GO:0030855; GO:0031528; GO:0032529; GO:0032533; GO:0035239; GO:0044331; GO:0045176; GO:2000370
GN013356	GN013356.1	Q9VEU1	26.3	194	604	2240	1.02e-10	68.9	CAD89_DROME	Cadherin-89D	Drosophila melanogaster (Fruit fly)	axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005912; GO:0007156; GO:0007409; GO:0016339; GO:0030855; GO:0044331
GN013359	GN013359.1	Q0MQH6	55.9	59	97	124	1.02e-14	67.4	NDUS6_GORGO	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit)	Gorilla gorilla gorilla (Western lowland gorilla)	mitochondrial electron transport, NADH to ubiquinone [GO:0006120]		mitochondrial inner membrane [GO:0005743]; respiratory chain complex I [GO:0045271]	GO:0005743; GO:0006120; GO:0045271
GN013363	GN013363.1	O43759	47.7	111	152	233	6.99e-31	114	SNG1_HUMAN	Synaptogyrin-1	Homo sapiens (Human)	regulated exocytosis [GO:0045055]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic vesicle membrane organization [GO:0048499]		azurophil granule membrane [GO:0035577]; cytosol [GO:0005829]; melanosome [GO:0042470]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle membrane [GO:0030672]	GO:0005829; GO:0005886; GO:0016020; GO:0030672; GO:0031594; GO:0035577; GO:0042470; GO:0045055; GO:0048169; GO:0048172; GO:0048499; GO:0098685
GN013364	GN013364.1	Q6PFK1	32.7	985	964	953	9.41e-109	362	ZN598_DANRE	E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	ribosome binding [GO:0043022]; ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]	GO:0005829; GO:0006513; GO:0016567; GO:0043022; GO:0061630; GO:0070534; GO:0072344; GO:1990116
GN013365	GN013365.1	O43301	28.7	579	588	675	3.63e-65	228	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN013366	GN013366.1	Q9XZV3	53.8	359	359	359	2.24e-131	382	GNAO_GEOCY	Guanine nucleotide-binding protein G(o) subunit alpha	Geodia cydonium (Sponge)	adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cytoskeleton organization [GO:0007010]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTPase activity [GO:0003924]; guanyl nucleotide binding [GO:0019001]	cytoplasm [GO:0005737]; heterotrimeric G-protein complex [GO:0005834]	GO:0001664; GO:0003924; GO:0005737; GO:0005834; GO:0007010; GO:0007188; GO:0019001; GO:0031683
GN013367	GN013367.1	O00142	52.4	103	176	265	1.07e-31	117	KITM_HUMAN	Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (2'-deoxyuridine kinase TK2) (EC 2.7.1.74) (Deoxycytidine kinase TK2) (EC 2.7.1.-) (Mt-TK)	Homo sapiens (Human)	deoxycytidine metabolic process [GO:0046092]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleoside salvage [GO:0043097]; thymidine metabolic process [GO:0046104]	ATP binding [GO:0005524]; deoxycytidine kinase activity [GO:0004137]; nucleoside kinase activity [GO:0019206]; thymidine kinase activity [GO:0004797]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004137; GO:0004797; GO:0005524; GO:0005737; GO:0005739; GO:0005759; GO:0006139; GO:0019206; GO:0043097; GO:0046092; GO:0046104
GN013369	GN013369.1	Q9ESV0	47.2	625	853	857	1.07e-156	483	DDX24_MOUSE	ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24)	Mus musculus (Mouse)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0016887
GN013371	GN013371.1	Q9H8H3	40.2	209	249	244	8.99e-45	153	TMT1A_HUMAN	Thiol S-methyltransferase TMT1A (EC 2.1.1.9) (Methyltransferase-like protein 7A) (N6-adenosine-methyltransferase TMT1A) (EC 2.1.1.348) (Protein AAM-B) (Thiol methyltransferase 1A)	Homo sapiens (Human)	lncRNA processing [GO:0180035]; odontogenesis [GO:0042476]; osteoblast differentiation [GO:0001649]	methyltransferase activity [GO:0008168]; mRNA m(6)A methyltransferase activity [GO:0001734]; RNA methyltransferase activity [GO:0008173]; thiol S-methyltransferase activity [GO:0018708]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; tertiary granule lumen [GO:1904724]	GO:0001649; GO:0001734; GO:0005576; GO:0005783; GO:0005811; GO:0005829; GO:0008168; GO:0008173; GO:0016020; GO:0018708; GO:0042476; GO:0180035; GO:1904724
GN013373	GN013373.1	P41233	55.0	647	713	2261	3.75e-243	739	ABCA1_MOUSE	Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cholesterol [GO:0071397]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endosomal transport [GO:0016197]; export across plasma membrane [GO:0140115]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein metabolic process [GO:0042157]; lysosome organization [GO:0007040]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; phospholipid transport [GO:0015914]; platelet dense granule organization [GO:0060155]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; protein lipidation [GO:0006497]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; regulation of Cdc42 protein signal transduction [GO:0032489]; response to laminar fluid shear stress [GO:0034616]; response to vitamin B3 [GO:0033552]; reverse cholesterol transport [GO:0043691]; signal release [GO:0023061]	ABC-type transporter activity [GO:0140359]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein A-I receptor activity [GO:0034188]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; high-density lipoprotein particle binding [GO:0008035]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transfer activity [GO:0120014]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; sphingolipid floppase activity [GO:0046623]; syntaxin binding [GO:0019905]; transmembrane protein transporter activity [GO:0008320]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	GO:0002790; GO:0005102; GO:0005524; GO:0005768; GO:0005794; GO:0005886; GO:0006497; GO:0006911; GO:0007040; GO:0007186; GO:0007189; GO:0008035; GO:0008203; GO:0008320; GO:0009306; GO:0009897; GO:0009986; GO:0010875; GO:0015914; GO:0016197; GO:0016323; GO:0016887; GO:0019905; GO:0023061; GO:0030139; GO:0030301; GO:0031210; GO:0031267; GO:0032367; GO:0032489; GO:0033344; GO:0033552; GO:0033700; GO:0034185; GO:0034186; GO:0034188; GO:0034380; GO:0034616; GO:0042157; GO:0042158; GO:0042626; GO:0042632; GO:0043691; GO:0045121; GO:0045332; GO:0045335; GO:0046623; GO:0048471; GO:0051117; GO:0055091; GO:0060155; GO:0071222; GO:0071300; GO:0071345; GO:0071397; GO:0071466; GO:0071806; GO:0090108; GO:0090554; GO:0090556; GO:0097708; GO:0120014; GO:0120020; GO:0140115; GO:0140326; GO:0140328; GO:0140359
GN013374	GN013374.1	P41233	39.4	1325	1463	2261	3.04e-281	868	ABCA1_MOUSE	Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cholesterol [GO:0071397]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endosomal transport [GO:0016197]; export across plasma membrane [GO:0140115]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein metabolic process [GO:0042157]; lysosome organization [GO:0007040]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; phospholipid transport [GO:0015914]; platelet dense granule organization [GO:0060155]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; protein lipidation [GO:0006497]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; regulation of Cdc42 protein signal transduction [GO:0032489]; response to laminar fluid shear stress [GO:0034616]; response to vitamin B3 [GO:0033552]; reverse cholesterol transport [GO:0043691]; signal release [GO:0023061]	ABC-type transporter activity [GO:0140359]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein A-I receptor activity [GO:0034188]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; high-density lipoprotein particle binding [GO:0008035]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transfer activity [GO:0120014]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; sphingolipid floppase activity [GO:0046623]; syntaxin binding [GO:0019905]; transmembrane protein transporter activity [GO:0008320]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	GO:0002790; GO:0005102; GO:0005524; GO:0005768; GO:0005794; GO:0005886; GO:0006497; GO:0006911; GO:0007040; GO:0007186; GO:0007189; GO:0008035; GO:0008203; GO:0008320; GO:0009306; GO:0009897; GO:0009986; GO:0010875; GO:0015914; GO:0016197; GO:0016323; GO:0016887; GO:0019905; GO:0023061; GO:0030139; GO:0030301; GO:0031210; GO:0031267; GO:0032367; GO:0032489; GO:0033344; GO:0033552; GO:0033700; GO:0034185; GO:0034186; GO:0034188; GO:0034380; GO:0034616; GO:0042157; GO:0042158; GO:0042626; GO:0042632; GO:0043691; GO:0045121; GO:0045332; GO:0045335; GO:0046623; GO:0048471; GO:0051117; GO:0055091; GO:0060155; GO:0071222; GO:0071300; GO:0071345; GO:0071397; GO:0071466; GO:0071806; GO:0090108; GO:0090554; GO:0090556; GO:0097708; GO:0120014; GO:0120020; GO:0140115; GO:0140326; GO:0140328; GO:0140359
GN013377	GN013377.1	Q9Y450	62.9	455	611	684	3.57e-200	580	HBS1L_HUMAN	HBS1-like protein (EC 3.6.5.-) (ERFS)	Homo sapiens (Human)	nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; signal transduction [GO:0007165]; translation [GO:0006412]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; Dom34-Hbs1 complex [GO:1990533]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0006412; GO:0007165; GO:0016020; GO:0022626; GO:0032790; GO:0070062; GO:0070966; GO:0072344; GO:1990533
GN013378	GN013378.1	Q9Y450	37.6	117	617	684	6.54e-13	75.5	HBS1L_HUMAN	HBS1-like protein (EC 3.6.5.-) (ERFS)	Homo sapiens (Human)	nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; signal transduction [GO:0007165]; translation [GO:0006412]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; Dom34-Hbs1 complex [GO:1990533]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0006412; GO:0007165; GO:0016020; GO:0022626; GO:0032790; GO:0070062; GO:0070966; GO:0072344; GO:1990533
GN013379	GN013379.1	A7RWC9	66.1	177	192	203	4.66e-87	257	ITPA_NEMVE	Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.66) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (XTP/dITP diphosphatase)	Nematostella vectensis (Starlet sea anemone)	deoxyribonucleoside triphosphate catabolic process [GO:0009204]; purine nucleoside triphosphate catabolic process [GO:0009146]	dITP diphosphatase activity [GO:0035870]; ITP diphosphatase activity [GO:0036220]; XTP diphosphatase activity [GO:0036222]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0009146; GO:0009204; GO:0035870; GO:0036220; GO:0036222
GN013380	GN013380.1	P08132	50.3	310	321	319	4.38e-94	285	ANXA4_PIG	Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II)	Sus scrofa (Pig)		calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786]	nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; zymogen granule membrane [GO:0042589]	GO:0001786; GO:0005509; GO:0005544; GO:0005634; GO:0005886; GO:0012506; GO:0042589
GN013383	GN013383.1	Q14686	45.6	103	879	2063	1.82e-16	88.6	NCOA6_HUMAN	Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)	Homo sapiens (Human)	brain development [GO:0007420]; DNA damage response [GO:0006974]; DNA-templated transcription initiation [GO:0006352]; heart development [GO:0007507]; myeloid cell differentiation [GO:0030099]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to hormone [GO:0009725]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713]	histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0003682; GO:0003713; GO:0005634; GO:0005654; GO:0005667; GO:0006352; GO:0006974; GO:0007420; GO:0007507; GO:0009725; GO:0019899; GO:0030099; GO:0030331; GO:0035097; GO:0044666; GO:0045893; GO:0045944; GO:0046965; GO:0046966
GN013385	GN013385.1	Q4KMA2	59.2	238	314	415	1.71e-62	206	RD23B_RAT	Lysine-specific demethylase RAD23B (EC 1.14.11.-) (UV excision repair protein RAD23 homolog B)	Rattus norvegicus (Rat)	cellular response to interleukin-7 [GO:0098761]; DNA damage response [GO:0006974]; embryonic organ development [GO:0048568]; nucleotide-excision repair [GO:0006289]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; spermatogenesis [GO:0007283]	damaged DNA binding [GO:0003684]; DNA damage sensor activity [GO:0140612]; histone H4K20 demethylase activity [GO:0035575]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; XPC complex [GO:0071942]	GO:0000976; GO:0000978; GO:0003684; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006289; GO:0006974; GO:0007283; GO:0031593; GO:0032434; GO:0035575; GO:0043161; GO:0048568; GO:0061629; GO:0071942; GO:0098761; GO:0140612
GN013386	GN013386.1	Q7T3H9	51.3	263	265	276	6.56e-94	280	HYI_DANRE	Putative hydroxypyruvate isomerase (EC 5.3.1.22)	Danio rerio (Zebrafish) (Brachydanio rerio)	glyoxylate metabolic process [GO:0046487]	hydroxypyruvate isomerase activity [GO:0008903]		GO:0008903; GO:0046487
GN013388	GN013388.1	P61026	78.5	200	199	200	1.90e-108	311	RAB10_HUMAN	Ras-related protein Rab-10 (EC 3.6.5.2)	Homo sapiens (Human)	antigen processing and presentation [GO:0019882]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; endocytic recycling [GO:0032456]; endoplasmic reticulum tubular network organization [GO:0071786]; endosomal transport [GO:0016197]; establishment of neuroblast polarity [GO:0045200]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; establishment of protein localization to membrane [GO:0090150]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; negative regulation of motile cilium assembly [GO:1905504]; polarized epithelial cell differentiation [GO:0030859]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to plasma membrane [GO:0072659]; regulated exocytosis [GO:0045055]; vesicle-mediated transport [GO:0016192]	cadherin binding involved in cell-cell adhesion [GO:0098641]; G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]	adherens junction [GO:0005912]; cilium [GO:0005929]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endosome [GO:0005768]; endosome membrane [GO:0010008]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; insulin-responsive compartment [GO:0032593]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; secretory vesicle [GO:0099503]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0003924; GO:0003925; GO:0005525; GO:0005764; GO:0005768; GO:0005789; GO:0005794; GO:0005802; GO:0005829; GO:0005886; GO:0005912; GO:0005925; GO:0005929; GO:0006887; GO:0006893; GO:0007409; GO:0010008; GO:0016192; GO:0016197; GO:0019003; GO:0019882; GO:0030659; GO:0030667; GO:0030670; GO:0030859; GO:0031489; GO:0032456; GO:0032593; GO:0032869; GO:0043001; GO:0045055; GO:0045200; GO:0048471; GO:0055037; GO:0055038; GO:0070062; GO:0070382; GO:0071782; GO:0071786; GO:0072659; GO:0090150; GO:0097051; GO:0098641; GO:0099503; GO:1903361; GO:1905504
GN013392	GN013392.1	Q3T102	74.9	402	413	445	3.38e-211	590	EIF3E_BOVIN	Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (eIF-3 p48)	Bos taurus (Bovine)	formation of cytoplasmic translation initiation complex [GO:0001732]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; translational initiation [GO:0006413]	translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; PML body [GO:0016605]	GO:0000184; GO:0001732; GO:0003743; GO:0005829; GO:0005852; GO:0006413; GO:0016282; GO:0016605; GO:0033290; GO:0071540
GN013393	GN013393.1	Q5M7L6	45.9	172	238	243	1.02e-57	186	RSPO2_XENTR	R-spondin-2 (Roof plate-specific spondin-2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	BMP signaling pathway [GO:0030509]; dorsal/ventral axis specification [GO:0009950]; lysosomal protein catabolic process [GO:1905146]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of canonical Wnt signaling pathway [GO:0090263]	BMP receptor binding [GO:0070700]	extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0005576; GO:0005764; GO:0009950; GO:0030509; GO:0030514; GO:0070700; GO:0090263; GO:1905146
GN013394	GN013394.1	Q3TYL0	38.5	96	139	540	9.77e-16	75.9	IQAK1_MOUSE	IQ motif and ankyrin repeat domain-containing protein 1	Mus musculus (Mouse)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN013395	GN013395.1	Q5EAE5	53.7	177	213	202	1.39e-62	196	JOS1_BOVIN	Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1)	Bos taurus (Bovine)	protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0004843; GO:0005829; GO:0005886; GO:0016579
GN013404	GN013404.1	P81431	78.5	302	317	378	2.09e-180	506	ADHX_OCTVU	Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284)	Octopus vulgaris (Common octopus)	formaldehyde catabolic process [GO:0046294]	alcohol dehydrogenase (NAD+) activity [GO:0004022]; S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity [GO:0106322]; S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity [GO:0106321]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]	GO:0004022; GO:0005829; GO:0008270; GO:0046294; GO:0106321; GO:0106322
GN013406	GN013406.1	Q8R151	32.8	1703	2091	1909	5.43e-253	802	ZNFX1_MOUSE	NFX1-type zinc finger-containing protein 1 (ATP- dependent RNA translocase ZNFX1) (EC 3.6.4.-) (E3 ubiquitin-protein and -ssRNA ligase ZNFX1) (EC 2.3.2.27)	Mus musculus (Mouse)	activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	helicase activity [GO:0004386]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380]	GO:0002218; GO:0003723; GO:0004386; GO:0005741; GO:0005829; GO:0008270; GO:0010494; GO:0031048; GO:0031380; GO:0042742; GO:0045071; GO:0051607; GO:0061630; GO:0140311; GO:1900226
GN013407	GN013407.1	Q9P2E3	31.3	1733	1777	1918	3.13e-228	728	ZNFX1_HUMAN	NFX1-type zinc finger-containing protein 1 (ATP- dependent RNA translocase ZNFX1) (EC 3.6.4.-) (E3 ubiquitin-protein and -ssRNA ligase ZNFX1) (EC 2.3.2.27)	Homo sapiens (Human)	activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	helicase activity [GO:0004386]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380]	GO:0002218; GO:0003723; GO:0004386; GO:0005741; GO:0005829; GO:0008270; GO:0010494; GO:0031048; GO:0031380; GO:0042742; GO:0045071; GO:0051607; GO:0061630; GO:0140311; GO:1900226
GN013417	GN013417.1	Q80TE7	56.9	58	85	1490	2.96e-14	69.3	LRRC7_MOUSE	Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1)	Mus musculus (Mouse)	cell-cell adhesion [GO:0098609]; clustering of voltage-gated calcium channels [GO:0070073]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of neuron projection development [GO:0010976]; receptor clustering [GO:0043113]; regulation of long-term synaptic depression [GO:1900452]	protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; axon initial segment [GO:0043194]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]	GO:0005737; GO:0005912; GO:0010976; GO:0014069; GO:0015629; GO:0016323; GO:0019901; GO:0030175; GO:0030674; GO:0043113; GO:0043194; GO:0043197; GO:0045197; GO:0070073; GO:0098609; GO:0098839; GO:0098887; GO:0098978; GO:1900452
GN013422	GN013422.1	Q9UDY4	56.3	332	326	337	3.98e-118	347	DNJB4_HUMAN	DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; protein folding [GO:0006457]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]	ATPase activator activity [GO:0001671]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; Z disc [GO:0030018]	GO:0000122; GO:0001671; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006457; GO:0006986; GO:0009408; GO:0030018; GO:0051087
GN013423	GN013423.1	A0JNC4	58.0	255	267	281	5.70e-104	306	ELOV7_BOVIN	Very long chain fatty acid elongase 7 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL7) (ELOVL fatty acid elongase 7) (ELOVL FA elongase 7) (Elongation of very long chain fatty acids protein 7) (Very long chain 3-ketoacyl-CoA synthase 7) (Very long chain 3-oxoacyl-CoA synthase 7)	Bos taurus (Bovine)	fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	fatty acid elongase activity [GO:0009922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0006636; GO:0009922; GO:0019367; GO:0030148; GO:0034625; GO:0034626; GO:0035338; GO:0042761
GN013428	GN013428.1	Q5E9A1	57.4	176	163	215	3.53e-42	142	NACA_BOVIN	Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC)	Bos taurus (Bovine)	protein targeting to membrane [GO:0006612]	TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005737; GO:0005854; GO:0006612; GO:0017025
GN013430	GN013430.1	Q5XX13	33.6	702	1247	1052	3.26e-104	358	FBW10_HUMAN	F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor)	Homo sapiens (Human)	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]		cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005829; GO:0019005; GO:0031146
GN013431	GN013431.1	Q29293	76.2	395	402	403	3.20e-231	639	RL3_PIG	Large ribosomal subunit protein uL3 (60S ribosomal protein L3)	Sus scrofa (Pig)	cytoplasmic translation [GO:0002181]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]; nucleolus [GO:0005730]	GO:0002181; GO:0003735; GO:0005730; GO:0005737; GO:0006412; GO:0022625
GN013432	GN013432.1	Q7Z020	27.9	129	352	1197	8.90e-10	63.9	TRPA1_DROME	Transient receptor potential cation channel subfamily A member 1 (dTRPA1) (Ankyrin-like with transmembrane domains protein 1) (dANKTM1)	Drosophila melanogaster (Fruit fly)	calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transport [GO:0006816]; cellular response to heat [GO:0034605]; cellular response to pulsatile fluid shear stress [GO:0097703]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of hot stimulus involved in thermoception [GO:0120168]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; detection of temperature stimulus involved in thermoception [GO:0050960]; mechanosensory behavior [GO:0007638]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; negative phototaxis [GO:0046957]; neuronal signal transduction [GO:0023041]; phototransduction [GO:0007602]; positive regulation of calcium-mediated signaling [GO:0050850]; response to heat [GO:0009408]; response to light stimulus [GO:0009416]; temperature compensation of the circadian clock [GO:0010378]; thermoception [GO:0050955]; thermosensory behavior [GO:0040040]; thermotaxis [GO:0043052]	calcium channel activity [GO:0005262]; intracellularly gated calcium channel activity [GO:0015278]; ligand-gated monoatomic ion channel activity [GO:0015276]; monoatomic cation channel activity [GO:0005261]; temperature-gated cation channel activity [GO:0097604]	cation channel complex [GO:0034703]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001580; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0006816; GO:0007602; GO:0007638; GO:0009408; GO:0009416; GO:0010378; GO:0015276; GO:0015278; GO:0016020; GO:0023041; GO:0034605; GO:0034703; GO:0040040; GO:0043052; GO:0046957; GO:0050850; GO:0050955; GO:0050960; GO:0050965; GO:0050968; GO:0097553; GO:0097604; GO:0097703; GO:0098655; GO:0120168
GN013434	GN013434.1	Q15392	61.6	305	309	516	8.40e-135	395	DHC24_HUMAN	Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1)	Homo sapiens (Human)	cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; negative regulation of cell population proliferation [GO:0008285]; Ras protein signal transduction [GO:0007265]; response to hormone [GO:0009725]; skin development [GO:0043588]; tissue development [GO:0009888]	Delta24(24-1) sterol reductase activity [GO:0000246]; Delta24-sterol reductase activity [GO:0050614]; enzyme binding [GO:0019899]; FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; peptide antigen binding [GO:0042605]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0000139; GO:0000246; GO:0005634; GO:0005783; GO:0005789; GO:0006695; GO:0007265; GO:0008285; GO:0009725; GO:0009888; GO:0016020; GO:0016628; GO:0019899; GO:0033489; GO:0033490; GO:0042605; GO:0043588; GO:0050614; GO:0071949
GN013435	GN013435.1	A7E320	65.1	43	80	786	2.57e-12	63.5	UHRF1_BOVIN	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Bos taurus (Bovine)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; response to stress [GO:0006950]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0006511; GO:0006950; GO:0008270; GO:0016567; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013437	GN013437.1	A7E320	65.1	43	80	786	2.57e-12	63.5	UHRF1_BOVIN	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Bos taurus (Bovine)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; response to stress [GO:0006950]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0006511; GO:0006950; GO:0008270; GO:0016567; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013438	GN013438.1	F6UA42	77.8	176	182	775	3.28e-92	287	UHRF1_XENTR	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase UHRF1) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0006511; GO:0008270; GO:0016567; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013439	GN013439.1	B6CHA3	47.3	188	201	772	4.24e-58	197	UHRF1_XENLA	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Nuclear zinc finger protein Np95) (XNp95) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Xenopus laevis (African clawed frog)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0006511; GO:0008270; GO:0016567; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013440	GN013440.1	E7EZF3	65.8	76	140	776	7.18e-27	107	UHRF1_DANRE	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	animal organ regeneration [GO:0031100]; chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; inflammatory response [GO:0006954]; intestinal epithelial structure maintenance [GO:0060729]; lens development in camera-type eye [GO:0002088]; liver development [GO:0001889]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0001889; GO:0002088; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0005737; GO:0006511; GO:0006954; GO:0008270; GO:0016567; GO:0031100; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0060729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013441	GN013441.1	Q9W6Z2	65.1	172	281	186	2.12e-75	231	TBPL1_XENLA	TATA box-binding protein-like 1 (TBP-like 1) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (xlTLF)	Xenopus laevis (African clawed frog)	DNA-templated transcription initiation [GO:0006352]; embryo development ending in birth or egg hatching [GO:0009792]; transcription by RNA polymerase II [GO:0006366]	DNA binding [GO:0003677]; general transcription initiation factor activity [GO:0140223]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0005737; GO:0006352; GO:0006366; GO:0009792; GO:0140223
GN013442	GN013442.1	Q15392	62.3	472	472	516	1.75e-222	624	DHC24_HUMAN	Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1)	Homo sapiens (Human)	cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; negative regulation of cell population proliferation [GO:0008285]; Ras protein signal transduction [GO:0007265]; response to hormone [GO:0009725]; skin development [GO:0043588]; tissue development [GO:0009888]	Delta24(24-1) sterol reductase activity [GO:0000246]; Delta24-sterol reductase activity [GO:0050614]; enzyme binding [GO:0019899]; FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; peptide antigen binding [GO:0042605]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0000139; GO:0000246; GO:0005634; GO:0005783; GO:0005789; GO:0006695; GO:0007265; GO:0008285; GO:0009725; GO:0009888; GO:0016020; GO:0016628; GO:0019899; GO:0033489; GO:0033490; GO:0042605; GO:0043588; GO:0050614; GO:0071949
GN013443	GN013443.1	F6UA42	54.4	807	798	775	4.54e-296	835	UHRF1_XENTR	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase UHRF1) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0006511; GO:0008270; GO:0016567; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013445	GN013445.1	Q15392	63.4	352	422	516	6.39e-163	471	DHC24_HUMAN	Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1)	Homo sapiens (Human)	cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; negative regulation of cell population proliferation [GO:0008285]; Ras protein signal transduction [GO:0007265]; response to hormone [GO:0009725]; skin development [GO:0043588]; tissue development [GO:0009888]	Delta24(24-1) sterol reductase activity [GO:0000246]; Delta24-sterol reductase activity [GO:0050614]; enzyme binding [GO:0019899]; FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; peptide antigen binding [GO:0042605]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0000139; GO:0000246; GO:0005634; GO:0005783; GO:0005789; GO:0006695; GO:0007265; GO:0008285; GO:0009725; GO:0009888; GO:0016020; GO:0016628; GO:0019899; GO:0033489; GO:0033490; GO:0042605; GO:0043588; GO:0050614; GO:0071949
GN013446	GN013446.1	Q96T88	42.4	92	96	793	2.84e-18	81.3	UHRF1_HUMAN	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear zinc finger protein Np95) (HuNp95) (Nuclear protein 95) (hNp95) (RING finger protein 106) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1)	Homo sapiens (Human)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; epigenetic regulation of gene expression [GO:0040029]; heterochromatin formation [GO:0031507]; homologous recombination [GO:0035825]; mitotic spindle assembly [GO:0090307]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autoubiquitination [GO:0051865]; protein localization to chromatin [GO:0071168]; regulation of epithelial cell proliferation [GO:0050678]; ubiquitin-dependent protein catabolic process [GO:0006511]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA damage sensor activity [GO:0140612]; hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3 ubiquitin ligase activity [GO:0141055]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; nucleic acid binding [GO:0003676]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; spindle [GO:0005819]	GO:0000122; GO:0000724; GO:0000785; GO:0000791; GO:0000792; GO:0000987; GO:0003676; GO:0004842; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005819; GO:0006511; GO:0006974; GO:0008270; GO:0008327; GO:0016363; GO:0031507; GO:0035825; GO:0040029; GO:0042393; GO:0042802; GO:0044027; GO:0044729; GO:0045944; GO:0050678; GO:0051247; GO:0051865; GO:0061630; GO:0062072; GO:0071168; GO:0090307; GO:0140234; GO:0140248; GO:0140612; GO:0140851; GO:0141055; GO:0141119
GN013447	GN013447.1	F6UA42	79.8	163	210	775	7.54e-86	272	UHRF1_XENTR	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase UHRF1) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0006511; GO:0008270; GO:0016567; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013448	GN013448.1	A7E320	65.1	43	80	786	2.57e-12	63.5	UHRF1_BOVIN	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Bos taurus (Bovine)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; response to stress [GO:0006950]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0006511; GO:0006950; GO:0008270; GO:0016567; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013449	GN013449.1	Q3UFS0	54.9	153	156	744	7.55e-46	162	ZY11B_MOUSE	Protein zyg-11 homolog B	Mus musculus (Mouse)	positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]		Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]	GO:0005737; GO:0006515; GO:0031462; GO:0032436
GN013455	GN013455.1	A9VFD6	35.2	352	482	392	1.78e-50	179	MTNK_BACMK	Methylthioribose kinase (MTR kinase) (EC 2.7.1.100)	Bacillus mycoides (strain KBAB4) (Bacillus weihenstephanensis)		ATP binding [GO:0005524]; S-methyl-5-thioribose kinase activity [GO:0046522]		GO:0005524; GO:0046522
GN013456	GN013456.1	B5X7X4	76.8	125	124	125	4.13e-60	183	LTOR2_SALSA	Ragulator complex protein LAMTOR2 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2)	Salmo salar (Atlantic salmon)	cellular response to amino acid stimulus [GO:0071230]; intracellular protein localization [GO:0008104]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of cell growth [GO:0001558]; regulation of cell-substrate junction organization [GO:0150116]	guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090]	late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; Ragulator complex [GO:0071986]	GO:0001558; GO:0005085; GO:0005765; GO:0005770; GO:0008104; GO:0031902; GO:0032008; GO:0060090; GO:0071230; GO:0071986; GO:0150116; GO:1904263
GN013457	GN013457.1	P80109	29.0	186	215	839	4.40e-16	79.7	PHLD_BOVIN	Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D)	Bos taurus (Bovine)	cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to cholesterol [GO:0071397]; cellular response to insulin stimulus [GO:0032869]; cellular response to pH [GO:0071467]; cellular response to triglyceride [GO:0071401]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; complement receptor mediated signaling pathway [GO:0002430]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of triglyceride catabolic process [GO:0010897]; ossification [GO:0001503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein secretion [GO:0009306]; regulation of cellular response to insulin stimulus [GO:1900076]; response to glucose [GO:0009749]; transepithelial transport [GO:0070633]	GPI anchor phospholipase D activity [GO:0004621]; sodium channel regulator activity [GO:0017080]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0001503; GO:0002042; GO:0002062; GO:0002430; GO:0004621; GO:0005576; GO:0005737; GO:0008285; GO:0008286; GO:0009306; GO:0009749; GO:0010595; GO:0010867; GO:0010897; GO:0010907; GO:0010983; GO:0017080; GO:0031012; GO:0032869; GO:0035774; GO:0043065; GO:0070633; GO:0071397; GO:0071401; GO:0071466; GO:0071467; GO:1900076
GN013458	GN013458.1	D4ACN8	48.2	139	251	147	3.57e-35	125	PLRKT_RAT	Plasminogen receptor (KT) (Plg-R(KT))	Rattus norvegicus (Rat)	positive regulation of plasminogen activation [GO:0010756]		plasma membrane [GO:0005886]	GO:0005886; GO:0010756
GN013461	GN013461.1	P80109	36.1	822	826	839	7.82e-137	429	PHLD_BOVIN	Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D)	Bos taurus (Bovine)	cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to cholesterol [GO:0071397]; cellular response to insulin stimulus [GO:0032869]; cellular response to pH [GO:0071467]; cellular response to triglyceride [GO:0071401]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; complement receptor mediated signaling pathway [GO:0002430]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of triglyceride catabolic process [GO:0010897]; ossification [GO:0001503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein secretion [GO:0009306]; regulation of cellular response to insulin stimulus [GO:1900076]; response to glucose [GO:0009749]; transepithelial transport [GO:0070633]	GPI anchor phospholipase D activity [GO:0004621]; sodium channel regulator activity [GO:0017080]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0001503; GO:0002042; GO:0002062; GO:0002430; GO:0004621; GO:0005576; GO:0005737; GO:0008285; GO:0008286; GO:0009306; GO:0009749; GO:0010595; GO:0010867; GO:0010897; GO:0010907; GO:0010983; GO:0017080; GO:0031012; GO:0032869; GO:0035774; GO:0043065; GO:0070633; GO:0071397; GO:0071401; GO:0071466; GO:0071467; GO:1900076
GN013462	GN013462.1	B5X7X4	76.8	125	124	125	4.13e-60	183	LTOR2_SALSA	Ragulator complex protein LAMTOR2 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2)	Salmo salar (Atlantic salmon)	cellular response to amino acid stimulus [GO:0071230]; intracellular protein localization [GO:0008104]; positive regulation of TOR signaling [GO:0032008]; positive regulation of TORC1 signaling [GO:1904263]; regulation of cell growth [GO:0001558]; regulation of cell-substrate junction organization [GO:0150116]	guanyl-nucleotide exchange factor activity [GO:0005085]; molecular adaptor activity [GO:0060090]	late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; Ragulator complex [GO:0071986]	GO:0001558; GO:0005085; GO:0005765; GO:0005770; GO:0008104; GO:0031902; GO:0032008; GO:0060090; GO:0071230; GO:0071986; GO:0150116; GO:1904263
GN013463	GN013463.1	Q9CS74	40.4	99	195	641	7.12e-15	75.5	ECD_MOUSE	Protein ecdysoneless homolog	Mus musculus (Mouse)	cell population proliferation [GO:0008283]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]	histone acetyltransferase binding [GO:0035035]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0008283; GO:0035035; GO:0045944; GO:2000045
GN013464	GN013464.1	A9VFD6	33.6	318	347	392	5.52e-41	150	MTNK_BACMK	Methylthioribose kinase (MTR kinase) (EC 2.7.1.100)	Bacillus mycoides (strain KBAB4) (Bacillus weihenstephanensis)		ATP binding [GO:0005524]; S-methyl-5-thioribose kinase activity [GO:0046522]		GO:0005524; GO:0046522
GN013468	GN013468.1	Q55G11	70.5	61	60	718	2.70e-22	90.9	NCSEB_DICDI	Neutral ceramidase B (N-CDase B) (NCDase B) (EC 3.5.1.23) (Acylsphingosine deacylase 2B) (N-acylsphingosine amidohydrolase 2B)	Dictyostelium discoideum (Social amoeba)	ceramide catabolic process [GO:0046514]; ceramide metabolic process [GO:0006672]; long-chain fatty acid biosynthetic process [GO:0042759]; sphingosine biosynthetic process [GO:0046512]	N-acylsphingosine amidohydrolase activity [GO:0017040]	extracellular region [GO:0005576]	GO:0005576; GO:0006672; GO:0017040; GO:0042759; GO:0046512; GO:0046514
GN013469	GN013469.1	Q55G11	58.5	398	393	718	1.27e-149	443	NCSEB_DICDI	Neutral ceramidase B (N-CDase B) (NCDase B) (EC 3.5.1.23) (Acylsphingosine deacylase 2B) (N-acylsphingosine amidohydrolase 2B)	Dictyostelium discoideum (Social amoeba)	ceramide catabolic process [GO:0046514]; ceramide metabolic process [GO:0006672]; long-chain fatty acid biosynthetic process [GO:0042759]; sphingosine biosynthetic process [GO:0046512]	N-acylsphingosine amidohydrolase activity [GO:0017040]	extracellular region [GO:0005576]	GO:0005576; GO:0006672; GO:0017040; GO:0042759; GO:0046512; GO:0046514
GN013470	GN013470.1	F4HQM3	49.6	236	273	779	8.65e-63	213	NCER1_ARATH	Neutral ceramidase 1 (AtNCER1) (N-CDase 1) (NCDase 1) (EC 3.5.1.23) (Acylsphingosine deacylase 1) (N-acylsphingosine amidohydrolase 1)	Arabidopsis thaliana (Mouse-ear cress)	cellular response to oxidative stress [GO:0034599]; ceramide catabolic process [GO:0046514]; intracellular sphingolipid homeostasis [GO:0090156]; long-chain fatty acid biosynthetic process [GO:0042759]; sphingosine biosynthetic process [GO:0046512]	N-acylsphingosine amidohydrolase activity [GO:0017040]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; plant-type vacuole [GO:0000325]	GO:0000325; GO:0005576; GO:0005783; GO:0005794; GO:0017040; GO:0034599; GO:0042759; GO:0046512; GO:0046514; GO:0090156
GN013473	GN013473.1	Q8BL48	43.7	829	803	810	6.17e-200	591	UNK_MOUSE	RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5)	Mus musculus (Mouse)	cell morphogenesis involved in neuron differentiation [GO:0048667]; in utero embryonic development [GO:0001701]; negative regulation of cytoplasmic translation [GO:2000766]; neuron migration [GO:0001764]	metal ion binding [GO:0046872]; mRNA CDS binding [GO:1990715]; ribosome binding [GO:0043022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0001701; GO:0001764; GO:0005737; GO:0005829; GO:0043022; GO:0046872; GO:0048667; GO:1990715; GO:2000766
GN013474	GN013474.1	Q13472	75.0	188	190	1001	1.76e-93	295	TOP3A_HUMAN	DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha)	Homo sapiens (Human)	chromosome separation [GO:0051304]; DNA topological change [GO:0006265]; double-strand break repair via homologous recombination [GO:0000724]; meiotic cell cycle [GO:0051321]; mitochondrial DNA metabolic process [GO:0032042]; resolution of DNA recombination intermediates [GO:0071139]	DNA binding [GO:0003677]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; RecQ family helicase-topoisomerase III complex [GO:0031422]	GO:0000724; GO:0003677; GO:0003697; GO:0003917; GO:0005634; GO:0005654; GO:0005739; GO:0005759; GO:0006265; GO:0008270; GO:0016605; GO:0031422; GO:0032042; GO:0051304; GO:0051321; GO:0071139
GN013476	GN013476.1	O70157	44.4	126	126	1003	7.95e-22	92.8	TOP3A_MOUSE	DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha)	Mus musculus (Mouse)	chromosome separation [GO:0051304]; DNA topological change [GO:0006265]; double-strand break repair via homologous recombination [GO:0000724]; mitochondrial DNA metabolic process [GO:0032042]; resolution of DNA recombination intermediates [GO:0071139]	DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; RecQ family helicase-topoisomerase III complex [GO:0031422]	GO:0000724; GO:0003697; GO:0003917; GO:0005634; GO:0005654; GO:0005759; GO:0006265; GO:0008270; GO:0016605; GO:0031422; GO:0032042; GO:0051304; GO:0071139
GN013477	GN013477.1	Q8MJK1	53.5	127	127	127	8.63e-40	132	CBY1_BOVIN	Protein chibby homolog 1 (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1)	Bos taurus (Bovine)	cardiac muscle cell differentiation [GO:0055007]; fat cell differentiation [GO:0045444]; negative regulation of Wnt signaling pathway [GO:0030178]		centriole [GO:0005814]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005634; GO:0005737; GO:0005794; GO:0005814; GO:0016607; GO:0030178; GO:0036126; GO:0045444; GO:0055007
GN013478	GN013478.1	Q5M7W4	33.2	609	790	965	1.54e-91	311	TMC5_RAT	Transmembrane channel-like protein 5	Rattus norvegicus (Rat)		mechanosensitive monoatomic ion channel activity [GO:0008381]	plasma membrane [GO:0005886]	GO:0005886; GO:0008381
GN013479	GN013479.1	A6H8I2	65.1	570	617	753	5.43e-269	758	SGSM3_XENLA	Small G protein signaling modulator 3 homolog (RUN and TBC1 domain-containing protein 3)	Xenopus laevis (African clawed frog)		GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]		GO:0005096; GO:0031267
GN013480	GN013480.1	Q7T2D0	74.4	156	159	755	2.10e-79	252	SGSM3_DANRE	Small G protein signaling modulator 3 (RUN and TBC1 domain-containing protein 3)	Danio rerio (Zebrafish) (Brachydanio rerio)		GTPase activator activity [GO:0005096]		GO:0005096
GN013484	GN013484.1	Q9VZW5	29.0	307	366	549	8.55e-32	129	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN013485	GN013485.1	Q9UBL3	60.9	110	124	628	4.71e-37	135	ASH2L_HUMAN	Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)	Homo sapiens (Human)	DNA damage response [GO:0006974]; hemopoiesis [GO:0030097]; positive regulation of cell population proliferation [GO:0008284]; response to estrogen [GO:0043627]; transcription initiation-coupled chromatin remodeling [GO:0045815]	beta-catenin binding [GO:0008013]; transcription cis-regulatory region binding [GO:0000976]	histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL1/2 complex [GO:0044665]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Set1C/COMPASS complex [GO:0048188]	GO:0000976; GO:0005634; GO:0005654; GO:0005886; GO:0006974; GO:0008013; GO:0008284; GO:0030097; GO:0035097; GO:0043627; GO:0044665; GO:0044666; GO:0045815; GO:0048188; GO:0071339
GN013488	GN013488.1	Q6TCH7	48.9	264	325	311	9.12e-98	294	PAQR3_HUMAN	Progestin and adipoQ receptor family member 3 (Progestin and adipoQ receptor family member III) (Raf kinase trapping to Golgi) (RKTG)	Homo sapiens (Human)	negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of SREBP signaling pathway [GO:2000640]; protein localization to Golgi apparatus [GO:0034067]	protein-membrane adaptor activity [GO:0043495]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0001933; GO:0005794; GO:0010977; GO:0032436; GO:0033137; GO:0034067; GO:0035359; GO:0043407; GO:0043495; GO:0045542; GO:1990756; GO:2000640
GN013490	GN013490.1	Q2M2I8	53.0	449	600	961	5.32e-133	415	AAK1_HUMAN	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)	Homo sapiens (Human)	membrane organization [GO:0061024]; positive regulation of Notch signaling pathway [GO:0045747]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of clathrin-dependent endocytosis [GO:2000369]; regulation of protein localization [GO:0032880]	AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; Notch binding [GO:0005112]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell leading edge [GO:0031252]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; terminal bouton [GO:0043195]	GO:0004674; GO:0005112; GO:0005524; GO:0005829; GO:0005886; GO:0005905; GO:0006468; GO:0030136; GO:0031252; GO:0032880; GO:0035612; GO:0043195; GO:0045747; GO:0050821; GO:0061024; GO:0098793; GO:0106310; GO:2000369
GN013492	GN013492.1	A7RJI7	52.0	421	422	459	3.04e-147	429	CCZ1_NEMVE	Vacuolar fusion protein CCZ1 homolog	Nematostella vectensis (Starlet sea anemone)	vacuolar transport [GO:0007034]; vesicle-mediated transport [GO:0016192]		Mon1-Ccz1 complex [GO:0035658]	GO:0007034; GO:0016192; GO:0035658
GN013493	GN013493.1	P25102	29.8	292	322	358	2.54e-27	112	HRH2_RAT	Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I)	Rattus norvegicus (Rat)	cellular response to histamine [GO:0071420]; chemical synaptic transmission [GO:0007268]; digestive tract development [GO:0048565]; epithelial cell morphogenesis [GO:0003382]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gastric acid secretion [GO:0001696]; gastrin-induced gastric acid secretion [GO:0001698]; gland development [GO:0048732]; histamine-induced gastric acid secretion [GO:0001697]; memory [GO:0007613]; negative regulation of arachidonate secretion [GO:1900139]; positive regulation of vasoconstriction [GO:0045907]; regulation of synaptic plasticity [GO:0048167]; visual learning [GO:0008542]	heterocyclic compound binding [GO:1901363]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0001696; GO:0001697; GO:0001698; GO:0003382; GO:0004969; GO:0005886; GO:0007187; GO:0007268; GO:0007613; GO:0008542; GO:0030425; GO:0030594; GO:0045202; GO:0045907; GO:0048167; GO:0048565; GO:0048732; GO:0071420; GO:1900139; GO:1901363
GN013500	GN013500.1	Q5R7U7	50.1	461	452	460	3.06e-150	438	DCTN4_PONAB	Dynactin subunit 4 (Dynactin subunit p62)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)			cell cortex [GO:0005938]; centrosome [GO:0005813]; dynactin complex [GO:0005869]; sarcomere [GO:0030017]; stress fiber [GO:0001725]	GO:0001725; GO:0005813; GO:0005869; GO:0005938; GO:0030017
GN013501	GN013501.1	I3PFJ3	37.7	228	270	275	3.98e-44	153	DOD1U_BETVU	4,5-DOPA dioxygenase extradiol 1 (EC 1.13.11.29)	Beta vulgaris (Sugar beet)		ferrous iron binding [GO:0008198]; stizolobate synthase activity [GO:0050297]; zinc ion binding [GO:0008270]		GO:0008198; GO:0008270; GO:0050297
GN013502	GN013502.1	Q04861	32.9	1076	1122	983	5.88e-151	479	NFKB1_CHICK	Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]	Gallus gallus (Chicken)	canonical NF-kappaB signal transduction [GO:0007249]; positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; NF-kappaB binding [GO:0051059]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; NF-kappaB p50/p65 complex [GO:0035525]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0005737; GO:0007249; GO:0035525; GO:0045944; GO:0051059
GN013503	GN013503.1	Q8N6G5	42.9	483	489	542	1.29e-128	387	CGAT2_HUMAN	Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2) (Beta4GalNAcT-2) (GalNAcT-2)	Homo sapiens (Human)	chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; proteoglycan biosynthetic process [GO:0030166]	acetylgalactosaminyltransferase activity [GO:0008376]; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047237]	Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0008376; GO:0016020; GO:0030166; GO:0032580; GO:0047237; GO:0047238; GO:0050650; GO:0050651
GN013504	GN013504.1	P00357	69.3	127	181	333	4.28e-58	187	G3P_HOMAM	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12)	Homarus americanus (American lobster)	glucose metabolic process [GO:0006006]; glyceraldehyde-3-phosphate metabolic process [GO:0019682]; glycolytic process [GO:0006096]	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; NADP binding [GO:0050661]	cytosol [GO:0005829]	GO:0004365; GO:0005829; GO:0006006; GO:0006096; GO:0019682; GO:0050661; GO:0051287
GN013508	GN013508.1	P52564	62.6	334	366	334	2.75e-140	404	MP2K6_HUMAN	Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)	Homo sapiens (Human)	bone development [GO:0060348]; cellular senescence [GO:0090398]; MAPK cascade [GO:0000165]; negative regulation of cold-induced thermogenesis [GO:0120163]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; osteoblast differentiation [GO:0001649]; p38MAPK cascade [GO:0038066]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; MAP kinase kinase activity [GO:0004708]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000165; GO:0001649; GO:0004674; GO:0004708; GO:0004713; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005856; GO:0007165; GO:0019901; GO:0031098; GO:0035872; GO:0038066; GO:0042770; GO:0042802; GO:0051403; GO:0051726; GO:0060348; GO:0090398; GO:0106310; GO:0120163; GO:1901796
GN013509	GN013509.1	Q2KHY5	44.1	177	214	215	3.16e-46	155	FAP24_BOVIN	Fanconi anemia core complex-associated protein 24 (Fanconi anemia-associated protein of 24 kDa)	Bos taurus (Bovine)	interstrand cross-link repair [GO:0036297]	chromatin binding [GO:0003682]	Fanconi anaemia nuclear complex [GO:0043240]	GO:0003682; GO:0036297; GO:0043240
GN013529	GN013529.1	Q7T102	49.5	95	170	471	1.89e-18	84.7	CCZ1_XENLA	Vacuolar fusion protein CCZ1 homolog	Xenopus laevis (African clawed frog)	vacuolar transport [GO:0007034]; vesicle-mediated transport [GO:0016192]		lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658]	GO:0005765; GO:0007034; GO:0016192; GO:0035658
GN013530	GN013530.1	Q96DM1	26.3	133	161	585	2.74e-13	69.7	PGBD4_HUMAN	PiggyBac transposable element-derived protein 4	Homo sapiens (Human)				
GN013532	GN013532.1	A5PKG7	80.2	192	439	234	3.37e-102	306	KCTD5_BOVIN	BTB/POZ domain-containing protein KCTD5	Bos taurus (Bovine)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]	cullin family protein binding [GO:0097602]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005829; GO:0031463; GO:0043161; GO:0051260; GO:0097602
GN013536	GN013536.1	Q6TCH7	49.2	264	325	311	1.29e-97	293	PAQR3_HUMAN	Progestin and adipoQ receptor family member 3 (Progestin and adipoQ receptor family member III) (Raf kinase trapping to Golgi) (RKTG)	Homo sapiens (Human)	negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of SREBP signaling pathway [GO:2000640]; protein localization to Golgi apparatus [GO:0034067]	protein-membrane adaptor activity [GO:0043495]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0001933; GO:0005794; GO:0010977; GO:0032436; GO:0033137; GO:0034067; GO:0035359; GO:0043407; GO:0043495; GO:0045542; GO:1990756; GO:2000640
GN013537	GN013537.1	Q2M2I8	52.2	450	1342	961	1.71e-129	427	AAK1_HUMAN	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)	Homo sapiens (Human)	membrane organization [GO:0061024]; positive regulation of Notch signaling pathway [GO:0045747]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of clathrin-dependent endocytosis [GO:2000369]; regulation of protein localization [GO:0032880]	AP-2 adaptor complex binding [GO:0035612]; ATP binding [GO:0005524]; Notch binding [GO:0005112]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell leading edge [GO:0031252]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; terminal bouton [GO:0043195]	GO:0004674; GO:0005112; GO:0005524; GO:0005829; GO:0005886; GO:0005905; GO:0006468; GO:0030136; GO:0031252; GO:0032880; GO:0035612; GO:0043195; GO:0045747; GO:0050821; GO:0061024; GO:0098793; GO:0106310; GO:2000369
GN013538	GN013538.1	Q8BL48	43.7	829	803	810	6.17e-200	591	UNK_MOUSE	RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5)	Mus musculus (Mouse)	cell morphogenesis involved in neuron differentiation [GO:0048667]; in utero embryonic development [GO:0001701]; negative regulation of cytoplasmic translation [GO:2000766]; neuron migration [GO:0001764]	metal ion binding [GO:0046872]; mRNA CDS binding [GO:1990715]; ribosome binding [GO:0043022]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0001701; GO:0001764; GO:0005737; GO:0005829; GO:0043022; GO:0046872; GO:0048667; GO:1990715; GO:2000766
GN013539	GN013539.1	O70157	53.3	1107	1097	1003	0.0	1097	TOP3A_MOUSE	DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha)	Mus musculus (Mouse)	chromosome separation [GO:0051304]; DNA topological change [GO:0006265]; double-strand break repair via homologous recombination [GO:0000724]; mitochondrial DNA metabolic process [GO:0032042]; resolution of DNA recombination intermediates [GO:0071139]	DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; RecQ family helicase-topoisomerase III complex [GO:0031422]	GO:0000724; GO:0003697; GO:0003917; GO:0005634; GO:0005654; GO:0005759; GO:0006265; GO:0008270; GO:0016605; GO:0031422; GO:0032042; GO:0051304; GO:0071139
GN013540	GN013540.1	Q8MJK1	53.5	127	127	127	8.63e-40	132	CBY1_BOVIN	Protein chibby homolog 1 (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1)	Bos taurus (Bovine)	cardiac muscle cell differentiation [GO:0055007]; fat cell differentiation [GO:0045444]; negative regulation of Wnt signaling pathway [GO:0030178]		centriole [GO:0005814]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005634; GO:0005737; GO:0005794; GO:0005814; GO:0016607; GO:0030178; GO:0036126; GO:0045444; GO:0055007
GN013541	GN013541.1	Q5M7W4	33.2	609	790	965	1.54e-91	311	TMC5_RAT	Transmembrane channel-like protein 5	Rattus norvegicus (Rat)		mechanosensitive monoatomic ion channel activity [GO:0008381]	plasma membrane [GO:0005886]	GO:0005886; GO:0008381
GN013542	GN013542.1	Q8IVV2	36.5	137	913	2067	4.39e-16	87.4	LOXH1_HUMAN	Lipoxygenase homology domain-containing protein 1	Homo sapiens (Human)	sensory perception of sound [GO:0007605]		stereocilium [GO:0032420]	GO:0007605; GO:0032420
GN013543	GN013543.1	Q8VCZ6	67.9	753	803	750	0.0	1052	SGSM3_MOUSE	Small G protein signaling modulator 3 (RUN and TBC1 domain-containing protein 3)	Mus musculus (Mouse)	endosomal transport [GO:0016197]; plasma membrane to endosome transport [GO:0048227]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein catabolic process [GO:0045732]; Rap protein signal transduction [GO:0032486]; regulation of endocytosis [GO:0030100]; regulation of Rab protein signal transduction [GO:0032483]	GTPase activator activity [GO:0005096]; GTPase regulator activity [GO:0030695]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; gap junction [GO:0005921]; Golgi apparatus [GO:0005794]	GO:0005096; GO:0005737; GO:0005794; GO:0005829; GO:0005921; GO:0016197; GO:0030100; GO:0030695; GO:0031267; GO:0032483; GO:0032486; GO:0043547; GO:0045732; GO:0048227
GN013547	GN013547.1	Q9VZW5	29.0	307	366	549	8.55e-32	129	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN013552	GN013552.1	P00367	73.2	515	539	558	3.86e-280	775	DHE3_HUMAN	Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)	Homo sapiens (Human)	L-glutamate biosynthetic process [GO:0097054]; L-glutamate catabolic process [GO:0006538]; L-glutamine metabolic process [GO:0006541]; positive regulation of insulin secretion [GO:0032024]; substantia nigra development [GO:0021762]; tricarboxylic acid metabolic process [GO:0072350]	ADP binding [GO:0043531]; GTP binding [GO:0005525]; L-glutamate dehydrogenase (NAD+) activity [GO:0004352]; L-glutamate dehydrogenase (NADP+) activity [GO:0004354]; L-glutamate dehydrogenase [NAD(P)+] activity [GO:0004353]; L-leucine binding [GO:0070728]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004352; GO:0004353; GO:0004354; GO:0005525; GO:0005737; GO:0005739; GO:0005759; GO:0005783; GO:0006538; GO:0006541; GO:0021762; GO:0032024; GO:0042803; GO:0043531; GO:0070403; GO:0070728; GO:0072350; GO:0097054
GN013553	GN013553.1	A2BHJ4	72.7	154	191	559	8.99e-27	109	CNO6L_DANRE	CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4)	Danio rerio (Zebrafish) (Brachydanio rerio)	nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]	3'-5'-RNA exonuclease activity [GO:0000175]; poly(A)-specific ribonuclease activity [GO:0004535]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000175; GO:0000289; GO:0004535; GO:0005634; GO:0005737; GO:0030014
GN013555	GN013555.1	Q8VEG6	58.1	377	866	555	1.86e-152	462	CNO6L_MOUSE	CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4)	Mus musculus (Mouse)	mRNA destabilization [GO:0061157]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]	3'-5'-RNA exonuclease activity [GO:0000175]; poly(A)-specific ribonuclease activity [GO:0004535]	CCR4-NOT complex [GO:0030014]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000175; GO:0000288; GO:0000289; GO:0004535; GO:0005634; GO:0005737; GO:0005829; GO:0008284; GO:0010606; GO:0030014; GO:0061157
GN013556	GN013556.1	Q9M2U3	30.8	253	263	406	2.39e-27	112	ALPL_ARATH	Protein ALP1-like (EC 3.1.-.-)	Arabidopsis thaliana (Mouse-ear cress)			histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634
GN013557	GN013557.1	Q9ERD9	37.9	346	357	407	4.67e-74	238	I23O1_RAT	Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)	Rattus norvegicus (Rat)	'de novo' NAD+ biosynthetic process from L-tryptophan [GO:0034354]; inflammatory response [GO:0006954]; kynurenic acid biosynthetic process [GO:0034276]; L-tryptophan catabolic process [GO:0006569]; multicellular organismal response to stress [GO:0033555]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of T cell apoptotic process [GO:0070233]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chronic inflammatory response [GO:0002678]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of T cell apoptotic process [GO:0070234]; positive regulation of T cell tolerance induction [GO:0002666]; positive regulation of type 2 immune response [GO:0002830]; quinolinate biosynthetic process [GO:0019805]; response to lipopolysaccharide [GO:0032496]; swimming behavior [GO:0036269]	amino acid binding [GO:0016597]; heme binding [GO:0020037]; indoleamine 2,3-dioxygenase activity [GO:0033754]; L-tryptophan 2,3-dioxygenase activity [GO:0004833]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; smooth muscle contractile fiber [GO:0030485]; stereocilium bundle [GO:0032421]	GO:0002666; GO:0002678; GO:0002830; GO:0004833; GO:0005737; GO:0005829; GO:0006569; GO:0006954; GO:0016597; GO:0019805; GO:0020037; GO:0030485; GO:0032421; GO:0032496; GO:0032693; GO:0032735; GO:0033555; GO:0033754; GO:0034276; GO:0034354; GO:0036269; GO:0042130; GO:0043065; GO:0046007; GO:0046872; GO:0070233; GO:0070234
GN013559	GN013559.1	Q7SXM7	65.1	441	430	508	7.97e-184	524	PRP31_DANRE	U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31)	Danio rerio (Zebrafish) (Brachydanio rerio)	mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; retina development in camera-type eye [GO:0060041]; spliceosomal tri-snRNP complex assembly [GO:0000244]	U4atac snRNA binding [GO:0030622]	Cajal body [GO:0015030]; MLL1 complex [GO:0071339]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690]	GO:0000244; GO:0000381; GO:0000398; GO:0005634; GO:0005687; GO:0005690; GO:0015030; GO:0016607; GO:0030622; GO:0046540; GO:0060041; GO:0071005; GO:0071011; GO:0071339; GO:0097526
GN013560	GN013560.1	Q6IR74	35.0	622	643	651	5.15e-120	374	CTL1_XENLA	Choline transporter-like protein 1 (Solute carrier family 44 member 1)	Xenopus laevis (African clawed frog)	choline transport [GO:0015871]; ethanolamine transport [GO:0034229]; transmembrane transport [GO:0055085]	choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]	mitochondrial outer membrane [GO:0005741]; plasma membrane [GO:0005886]	GO:0005741; GO:0005886; GO:0015220; GO:0015871; GO:0034228; GO:0034229; GO:0055085
GN013561	GN013561.1	Q8IUF1	57.1	331	421	395	1.24e-130	384	ZNG1B_HUMAN	Zinc-regulated GTPase metalloprotein activator 1B (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 2) (COBW domain-containing protein 2)	Homo sapiens (Human)	protein maturation [GO:0051604]	GTPase activity [GO:0003924]; zinc chaperone activity [GO:0140827]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0003924; GO:0005634; GO:0008270; GO:0051604; GO:0140827
GN013562	GN013562.1	C9JTQ0	39.8	128	382	380	3.58e-18	88.6	ANR63_HUMAN	Ankyrin repeat domain-containing protein 63	Homo sapiens (Human)				
GN013565	GN013565.1	P55809	64.4	523	508	520	8.18e-229	642	SCOT1_HUMAN	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase)	Homo sapiens (Human)	adipose tissue development [GO:0060612]; heart development [GO:0007507]; ketone body catabolic process [GO:0046952]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; response to activity [GO:0014823]; response to ethanol [GO:0045471]; response to hormone [GO:0009725]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to xenobiotic stimulus [GO:0009410]	identical protein binding [GO:0042802]; succinyl-CoA:3-oxo-acid CoA-transferase activity [GO:0008260]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0007507; GO:0007584; GO:0008260; GO:0009410; GO:0009725; GO:0014823; GO:0035774; GO:0042594; GO:0042802; GO:0045471; GO:0046952; GO:0060612
GN013572	GN013572.1	Q3U6K5	27.6	539	513	488	2.01e-36	144	SPAT6_MOUSE	Spermatogenesis-associated protein 6 (Kinesin-related protein)	Mus musculus (Mouse)	motile cilium assembly [GO:0044458]; spermatogenesis [GO:0007283]	myosin light chain binding [GO:0032027]	extracellular region [GO:0005576]; motile cilium [GO:0031514]; sperm head-tail coupling apparatus [GO:0120212]	GO:0005576; GO:0007283; GO:0031514; GO:0032027; GO:0044458; GO:0120212
GN013573	GN013573.1	Q2NL11	27.2	257	301	293	1.32e-21	95.5	CH074_BOVIN	Uncharacterized protein C8orf74 homolog	Bos taurus (Bovine)				
GN013578	GN013578.1	Q8AV57	37.3	2192	2149	2177	0.0	1287	SDK2_CHICK	Protein sidekick-2	Gallus gallus (Chicken)	camera-type eye photoreceptor cell differentiation [GO:0060219]; homophilic cell-cell adhesion [GO:0007156]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416]	identical protein binding [GO:0042802]	plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0005886; GO:0007156; GO:0007416; GO:0010842; GO:0042802; GO:0045202; GO:0060219
GN013579	GN013579.1	O13035	25.6	515	835	518	1.70e-52	194	SAP_CHICK	Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A; Saposin-B; Saposin-C; Saposin-D]	Gallus gallus (Chicken)	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; prostate gland growth [GO:0060736]; regulation of lipid metabolic process [GO:0019216]; sphingolipid metabolic process [GO:0006665]		extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0005576; GO:0005764; GO:0006665; GO:0007193; GO:0019216; GO:0060736; GO:0060742
GN013580	GN013580.1	Q5XGZ9	28.6	643	613	614	9.73e-60	213	MF6LB_XENLA	Major facilitator superfamily domain-containing protein 6-like protein B	Xenopus laevis (African clawed frog)			membrane [GO:0016020]	GO:0016020
GN013581	GN013581.1	F1R8Z9	40.5	333	428	442	1.44e-64	216	FXJ1B_DANRE	Forkhead box protein J1-B	Danio rerio (Zebrafish) (Brachydanio rerio)	auditory receptor cell stereocilium organization [GO:0060088]; cilium assembly [GO:0060271]; determination of left/right symmetry [GO:0007368]; heart jogging [GO:0003146]; heart looping [GO:0001947]; motile cilium assembly [GO:0044458]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001947; GO:0003146; GO:0005634; GO:0006357; GO:0007368; GO:0044458; GO:0060088; GO:0060271
GN013582	GN013582.1	Q9Y2W2	42.9	648	567	641	1.30e-53	196	WBP11_HUMAN	WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1)	Homo sapiens (Human)	RNA splicing [GO:0008380]	protein phosphatase regulator activity [GO:0019888]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; WW domain binding [GO:0050699]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003697; GO:0003723; GO:0005634; GO:0005654; GO:0005829; GO:0008380; GO:0019888; GO:0050699
GN013583	GN013583.1	O54922	42.0	619	621	653	2.06e-152	457	EXOC7_RAT	Exocyst complex component 7 (Exocyst complex component Exo70) (rExo70)	Rattus norvegicus (Rat)	exocytosis [GO:0006887]; positive regulation of mitotic cytokinetic process [GO:1903438]; protein localization to ciliary membrane [GO:1903441]; protein transmembrane transport [GO:0071806]; regulation of entry of bacterium into host cell [GO:2000535]; regulation of synapse assembly [GO:0051963]	phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-macromolecule adaptor activity [GO:0030674]	9+0 non-motile cilium [GO:0097731]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone membrane [GO:0032584]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]	GO:0000145; GO:0005546; GO:0005815; GO:0005829; GO:0005886; GO:0006887; GO:0030496; GO:0030674; GO:0032154; GO:0032584; GO:0034451; GO:0036064; GO:0051963; GO:0071806; GO:0090543; GO:0097546; GO:0097731; GO:0098793; GO:0098794; GO:1903438; GO:1903441; GO:2000535
GN013584	GN013584.1	F1NV61	46.7	289	307	309	4.34e-80	248	CASP7_CHICK	Caspase-7 (CASP-7) (EC 3.4.22.60) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]	Gallus gallus (Chicken)	apoptotic process [GO:0006915]; defense response to bacterium [GO:0042742]; execution phase of apoptosis [GO:0097194]; lymphocyte apoptotic process [GO:0070227]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of plasma membrane repair [GO:1905686]; proteolysis [GO:0006508]	aspartic-type endopeptidase activity [GO:0004190]; cysteine-type endopeptidase activity [GO:0004197]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0003723; GO:0004190; GO:0004197; GO:0005576; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0042742; GO:0043525; GO:0070227; GO:0097194; GO:1905686
GN013585	GN013585.1	Q9V727	59.6	178	1097	1669	1.75e-48	192	ASX_DROME	Polycomb group protein Asx (Protein additional sex combs)	Drosophila melanogaster (Fruit fly)	animal organ morphogenesis [GO:0009887]; antennal development [GO:0007469]; anterior/posterior axis specification [GO:0009948]; apposition of dorsal and ventral imaginal disc-derived wing surfaces [GO:0007475]; cell fate determination [GO:0001709]; epigenetic regulation of gene expression [GO:0040029]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; sex comb development [GO:0045498]; syncytial blastoderm mitotic cell cycle [GO:0035186]	chromatin binding [GO:0003682]; deubiquitinase activator activity [GO:0035800]; DNA binding [GO:0003677]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleus [GO:0005634]; PR-DUB complex [GO:0035517]	GO:0000785; GO:0001709; GO:0003677; GO:0003682; GO:0005634; GO:0005694; GO:0006357; GO:0007469; GO:0007475; GO:0009887; GO:0009948; GO:0010468; GO:0035186; GO:0035517; GO:0035800; GO:0040029; GO:0045498; GO:0045892; GO:0045893; GO:0045944
GN013586	GN013586.1	Q5BJE1	21.2	853	928	867	1.11e-19	98.6	CC178_HUMAN	Coiled-coil domain-containing protein 178	Homo sapiens (Human)	manchette assembly [GO:1905198]; spermatid development [GO:0007286]		centrosome [GO:0005813]; ciliary basal body [GO:0036064]	GO:0005813; GO:0007286; GO:0036064; GO:1905198
GN013587	GN013587.1	Q9CXL3	46.3	95	375	195	1.73e-17	83.2	CHOLN_MOUSE	Cholesin (Protein C7orf50 homolog)	Mus musculus (Mouse)	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; negative regulation of cholesterol biosynthetic process [GO:0045541]; positive regulation of cholesterol biosynthetic process [GO:0045542]; regulation of cholesterol biosynthetic process [GO:0045540]	hormone activity [GO:0005179]	extracellular region [GO:0005576]	GO:0005179; GO:0005576; GO:0007193; GO:0045540; GO:0045541; GO:0045542
GN013588	GN013588.1	Q5ZKE7	56.6	173	246	196	2.76e-59	189	KCY_CHICK	UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK)	Gallus gallus (Chicken)	'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; CDP biosynthetic process [GO:0046705]; UDP biosynthetic process [GO:0006225]	ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; dCMP kinase activity [GO:0036431]; nucleoside diphosphate kinase activity [GO:0004550]; UMP kinase activity [GO:0033862]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004550; GO:0005524; GO:0005634; GO:0005737; GO:0006207; GO:0006225; GO:0033862; GO:0036430; GO:0036431; GO:0046705
GN013589	GN013589.1	Q84JE8	28.3	336	327	694	4.79e-16	82.4	ZDP_ARATH	Polynucleotide 3'-phosphatase ZDP (EC 3.1.3.32) (DNA nick sensor protein)	Arabidopsis thaliana (Mouse-ear cress)	base-excision repair [GO:0006284]; DNA repair [GO:0006281]; double-strand break repair via nonhomologous end joining [GO:0006303]; single strand break repair [GO:0000012]	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; DNA binding [GO:0003677]; polynucleotide 3'-phosphatase activity [GO:0046403]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000012; GO:0003677; GO:0005634; GO:0005654; GO:0006281; GO:0006284; GO:0006303; GO:0008270; GO:0046403; GO:0046404
GN013590	GN013590.1	Q15468	38.1	446	1495	1287	5.00e-77	284	STIL_HUMAN	SCL-interrupting locus protein (TAL-1-interrupting locus protein)	Homo sapiens (Human)	centrosome duplication [GO:0051298]; determination of left/right symmetry [GO:0007368]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; forebrain development [GO:0030900]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; microtubule organizing center organization [GO:0031023]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; notochord development [GO:0030903]; positive regulation of centriole replication [GO:0046601]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of spindle assembly [GO:1905832]; protein localization to centrosome [GO:0071539]; regulation of centriole replication [GO:0046599]; regulation of mitotic spindle organization [GO:0060236]; smoothened signaling pathway [GO:0007224]	identical protein binding [GO:0042802]	cell cortex [GO:0005938]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; procentriole replication complex [GO:0120099]	GO:0000578; GO:0001701; GO:0001843; GO:0001947; GO:0005737; GO:0005813; GO:0005814; GO:0005815; GO:0005829; GO:0005938; GO:0007052; GO:0007224; GO:0007368; GO:0021915; GO:0030900; GO:0030903; GO:0031023; GO:0033504; GO:0035264; GO:0036064; GO:0042802; GO:0043066; GO:0046599; GO:0046601; GO:0051298; GO:0060236; GO:0071539; GO:0120099; GO:1900087; GO:1905832
GN013591	GN013591.1	Q90YL3	60.0	80	636	589	9.50e-21	100	MED26_DANRE	Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26)	Danio rerio (Zebrafish) (Brachydanio rerio)	positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]	transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleoplasm [GO:0005654]	GO:0003712; GO:0005654; GO:0006357; GO:0010628; GO:0016592; GO:0070847
GN013592	GN013592.1	O59697	38.7	137	1072	423	3.32e-21	101	PPK25_SCHPO	Serine/threonine-protein kinase ppk25 (EC 2.7.11.1)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	signal transduction [GO:0007165]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0007165; GO:0106310
GN013593	GN013593.1	Q8T3B9	70.3	101	339	404	4.09e-41	151	SEM2_CAEEL	Transcription factor sem-2 (Sex muscle abnormal protein 2)	Caenorhabditis elegans	brain development [GO:0007420]; mesodermal cell fate specification [GO:0007501]; myoblast fate specification [GO:0048626]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of egg-laying behavior [GO:1901046]; positive regulation of embryonic development [GO:0040019]; positive regulation of mesodermal cell fate specification [GO:0048337]; positive regulation of post-embryonic development [GO:0048582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vulval development [GO:0040026]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0001228; GO:0003677; GO:0005634; GO:0007420; GO:0007501; GO:0030182; GO:0040019; GO:0040026; GO:0045944; GO:0048337; GO:0048582; GO:0048626; GO:1901046
GN013597	GN013597.1	Q9TT23	25.8	217	269	325	3.01e-10	63.2	MC5R_PANTR	Melanocortin receptor 5 (MC5-R)	Pan troglodytes (Chimpanzee)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; negative regulation of immune response [GO:0050777]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; temperature homeostasis [GO:0001659]	corticotropin receptor activity [GO:0004978]; melanocortin receptor activity [GO:0004977]; melanocyte-stimulating hormone receptor activity [GO:0004980]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0001659; GO:0004977; GO:0004978; GO:0004980; GO:0005737; GO:0005886; GO:0007189; GO:0045921; GO:0050777; GO:0070374
GN013601	GN013601.1	P30974	35.5	335	432	504	6.11e-49	177	TLR1_DROME	Tachykinin-like peptides receptor 86C (NKD)	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; inter-male aggressive behavior [GO:0002121]; neuropeptide signaling pathway [GO:0007218]; tachykinin receptor signaling pathway [GO:0007217]	neuropeptide receptor activity [GO:0008188]; tachykinin receptor activity [GO:0004995]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0002121; GO:0004995; GO:0005886; GO:0007186; GO:0007217; GO:0007218; GO:0008188; GO:0016020
GN013603	GN013603.1	Q9WYJ1	41.5	313	327	401	2.97e-64	211	TSAL_THEMA	L-threonine ammonia-lyase (EC 4.3.1.19) (L-serine ammonia-lyase) (EC 4.3.1.17) (Threonine dehydratase)	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	L-serine catabolic process [GO:0006565]; L-threonine catabolic process [GO:0006567]	L-serine ammonia-lyase activity [GO:0003941]; pyridoxal phosphate binding [GO:0030170]; threonine deaminase activity [GO:0004794]		GO:0003941; GO:0004794; GO:0006565; GO:0006567; GO:0030170
GN013607	GN013607.1	Q12857	46.6	564	732	509	5.69e-104	330	NFIA_HUMAN	Nuclear factor 1 A-type (NF1-A) (Nuclear factor 1/A) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/A) (NF-I/A) (NFI-A) (TGGCA-binding protein)	Homo sapiens (Human)	BMP signaling pathway [GO:0030509]; cartilage development [GO:0051216]; cell morphogenesis [GO:0000902]; limb morphogenesis [GO:0035108]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; viral genome replication [GO:0019079]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000902; GO:0000978; GO:0000981; GO:0001228; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0006355; GO:0006357; GO:0019079; GO:0030509; GO:0035108; GO:0045944; GO:0051216; GO:0140297
GN013608	GN013608.1	Q865S1	59.0	1217	1194	1207	0.0	1250	AP3D1_BOVIN	AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (BLVPCP1) (Bovine leukemia virus cell receptor) (BLV-R) (Delta-adaptin)	Bos taurus (Bovine)	anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; Golgi to vacuole transport [GO:0006896]; neurotransmitter receptor transport, postsynaptic endosome to lysosome [GO:0098943]; protein targeting to vacuole [GO:0006623]; synaptic vesicle budding from endosome [GO:0016182]; synaptic vesicle membrane organization [GO:0048499]		AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; presynaptic endosome [GO:0098830]; terminal bouton [GO:0043195]	GO:0000139; GO:0006623; GO:0006896; GO:0008089; GO:0010008; GO:0016182; GO:0030123; GO:0043195; GO:0048490; GO:0048499; GO:0098830; GO:0098943; GO:1904115
GN013609	GN013609.1	P29540	51.2	287	285	288	2.33e-92	278	T2EB_XENLA	General transcription factor IIE subunit 2 (Transcription initiation factor IIE subunit beta) (TFIIE-beta)	Xenopus laevis (African clawed frog)	transcription initiation at RNA polymerase II promoter [GO:0006367]	RNA polymerase II general transcription initiation factor activity [GO:0016251]; TFIIH-class transcription factor complex binding [GO:0001097]	transcription factor TFIIE complex [GO:0005673]	GO:0001097; GO:0005673; GO:0006367; GO:0016251
GN013611	GN013611.1	Q504A5	44.4	216	244	232	2.45e-60	192	TPMT_DANRE	Probable thiopurine S-methyltransferase (Thiopurine methyltransferase) (EC 2.1.1.67)	Danio rerio (Zebrafish) (Brachydanio rerio)		thiopurine S-methyltransferase activity [GO:0008119]	cytoplasm [GO:0005737]	GO:0005737; GO:0008119
GN013613	GN013613.1	A0A182C2Z2	33.5	556	888	1575	1.77e-73	267	OVCH_HALRO	Ovochymase (HrOVCH) (EC 3.4.21.-)	Halocynthia roretzi (Sea squirt) (Cynthia roretzi)	fertilization [GO:0009566]; oogenesis [GO:0048477]; proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]	GO:0004252; GO:0005576; GO:0006508; GO:0009566; GO:0048477
GN013615	GN013615.1	Q5XGS8	72.8	525	606	654	3.88e-271	759	GTPB1_XENLA	GTP-binding protein 1 (EC 3.6.5.3)	Xenopus laevis (African clawed frog)	GTP metabolic process [GO:0046039]; positive regulation of mRNA catabolic process [GO:0061014]; RNA surveillance [GO:0071025]; translational elongation [GO:0006414]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]	GO:0000049; GO:0000177; GO:0003746; GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0006414; GO:0046039; GO:0061014; GO:0071025
GN013616	GN013616.1	Q5BK24	38.5	169	245	374	1.26e-23	100	CH076_RAT	Uncharacterized protein C8orf76 homolog	Rattus norvegicus (Rat)				
GN013617	GN013617.1	Q8K2L8	48.3	445	797	797	2.01e-134	421	TPC12_MOUSE	Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15)	Mus musculus (Mouse)	COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; metaphase chromosome alignment [GO:0051310]; positive regulation of protein localization to kinetochore [GO:1905342]; regulation of kinetochore assembly [GO:0090234]; vesicle tethering [GO:0099022]		cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072]	GO:0000776; GO:0005634; GO:0005654; GO:0005737; GO:0005793; GO:0005794; GO:0006888; GO:0007030; GO:0030008; GO:0048208; GO:0048471; GO:0051310; GO:0090234; GO:0099022; GO:1905342; GO:1990072
GN013618	GN013618.1	Q01538	42.1	625	769	1121	3.00e-49	191	MYT1_HUMAN	Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein)	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000981; GO:0003700; GO:0005634; GO:0005654; GO:0006355; GO:0008270
GN013619	GN013619.1	Q9NV79	63.7	262	583	361	5.40e-116	352	PCMD2_HUMAN	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2	Homo sapiens (Human)		protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719]	cytoplasm [GO:0005737]	GO:0004719; GO:0005737
GN013620	GN013620.1	Q96JM7	41.5	840	1429	780	1.49e-195	598	LMBL3_HUMAN	Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1)	Homo sapiens (Human)	negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription initiation-coupled chromatin remodeling [GO:0160217]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; methylation-dependent protein binding [GO:0140034]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003682; GO:0005634; GO:0005654; GO:0005730; GO:0008270; GO:0042393; GO:0042802; GO:0045892; GO:0140034; GO:0160217; GO:2000060
GN013622	GN013622.1	Q9P2K1	44.3	817	763	1620	8.27e-223	673	C2D2A_HUMAN	Coiled-coil and C2 domain-containing protein 2A	Homo sapiens (Human)	cilium assembly [GO:0060271]; non-motile cilium assembly [GO:1905515]; protein localization to ciliary transition zone [GO:1904491]; smoothened signaling pathway [GO:0007224]		ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; MKS complex [GO:0036038]	GO:0005829; GO:0007224; GO:0035869; GO:0036038; GO:0060271; GO:1904491; GO:1905515
GN013625	GN013625.1	Q8R3G1	54.9	339	330	351	3.66e-113	335	PP1R8_MOUSE	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8)	Mus musculus (Mouse)	cell population proliferation [GO:0008283]	molecular function inhibitor activity [GO:0140678]; mRNA binding [GO:0003729]; protein phosphatase regulator activity [GO:0019888]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; RNA endonuclease activity [GO:0004521]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	GO:0003729; GO:0004521; GO:0004865; GO:0005654; GO:0008283; GO:0016607; GO:0019888; GO:0140678
GN013626	GN013626.1	Q5FW38	47.8	69	201	462	1.95e-09	59.7	NFIL3_XENTR	Nuclear factor interleukin-3-regulated protein	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	circadian rhythm [GO:0007623]; immune response [GO:0006955]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; transcription by RNA polymerase II [GO:0006366]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0006355; GO:0006366; GO:0006955; GO:0007623; GO:0045892
GN013628	GN013628.1	Q7RTU0	70.0	90	178	167	1.92e-32	117	TCF24_HUMAN	Transcription factor 24 (TCF-24)	Homo sapiens (Human)	developmental process [GO:0032502]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0032502; GO:0046983
GN013633	GN013633.1	P37091	25.9	549	656	650	8.82e-46	176	SCNNG_RAT	Epithelial sodium channel subunit gamma (Gamma-ENaC) (pithelial Na(+) channel subunit gamma) (Amiloride-sensitive sodium channel subunit gamma) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG)	Rattus norvegicus (Rat)	cellular response to acidic pH [GO:0071468]; cellular response to aldosterone [GO:1904045]; cellular response to vasopressin [GO:1904117]; intracellular sodium ion homeostasis [GO:0006883]; multicellular organismal-level water homeostasis [GO:0050891]; regulation of blood pressure [GO:0008217]; response to hypoxia [GO:0001666]; sensory perception of salty taste [GO:0050914]; sensory perception of sour taste [GO:0050915]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; wound healing, spreading of epidermal cells [GO:0035313]	ligand-gated sodium channel activity [GO:0015280]; monoatomic ion channel activity [GO:0005216]; sodium channel activity [GO:0005272]; WW domain binding [GO:0050699]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]	GO:0001666; GO:0005216; GO:0005272; GO:0005886; GO:0006814; GO:0006883; GO:0008217; GO:0009897; GO:0009986; GO:0015280; GO:0016020; GO:0016324; GO:0034706; GO:0035313; GO:0035725; GO:0050699; GO:0050891; GO:0050914; GO:0050915; GO:0055078; GO:0070062; GO:0071468; GO:0098719; GO:1904045; GO:1904117
GN013635	GN013635.1	B0DOB4	37.1	1479	1439	1430	9.74e-301	894	NPHP4_XENLA	Nephrocystin-4	Xenopus laevis (African clawed frog)	negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein localization to ciliary transition zone [GO:1904491]		ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition zone [GO:0035869]; non-motile cilium [GO:0097730]	GO:0035869; GO:0036064; GO:0090090; GO:0097546; GO:0097730; GO:1904491
GN013636	GN013636.1	Q9NX55	62.2	98	117	121	9.67e-33	114	HYPK_HUMAN	Huntingtin-interacting protein K (Huntingtin yeast partner K)	Homo sapiens (Human)	negative regulation of apoptotic process [GO:0043066]; protein stabilization [GO:0050821]	protein folding chaperone [GO:0044183]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0005634; GO:0005654; GO:0005737; GO:0032991; GO:0043066; GO:0044183; GO:0050821
GN013637	GN013637.1	Q4R4T9	44.4	234	512	499	2.01e-38	150	RANB3_MACFA	Ran-binding protein 3 (RanBP3)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	protein export from nucleus [GO:0006611]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0006611
GN013638	GN013638.1	Q80VC6	54.2	155	207	287	9.00e-55	179	TSAP1_MOUSE	tRNA selenocysteine 1-associated protein 1 (SECp43) (tRNA selenocysteine-associated protein 1)	Mus musculus (Mouse)	selenocysteine incorporation [GO:0001514]	tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000049; GO:0001514; GO:0005634; GO:0005737
GN013639	GN013639.1	Q2NKS3	38.9	113	125	122	9.71e-20	81.3	PSMG3_BOVIN	Proteasome assembly chaperone 3	Bos taurus (Bovine)	chaperone-mediated protein complex assembly [GO:0051131]; proteasome assembly [GO:0043248]	molecular adaptor activity [GO:0060090]; protein-containing complex binding [GO:0044877]	protein folding chaperone complex [GO:0101031]	GO:0043248; GO:0044877; GO:0051131; GO:0060090; GO:0101031
GN013640	GN013640.1	Q9V6K3	46.6	509	466	724	2.38e-153	456	ROR2_DROME	Tyrosine-protein kinase transmembrane receptor Ror2 (dRor2) (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase)	Drosophila melanogaster (Fruit fly)	cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; muscle cell cellular homeostasis [GO:0046716]; photoreceptor cell axon guidance [GO:0072499]; rhabdomere development [GO:0042052]; signal transduction [GO:0007165]	ATP binding [GO:0005524]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; Wnt-protein binding [GO:0017147]	plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004713; GO:0004714; GO:0005524; GO:0005886; GO:0007165; GO:0007169; GO:0017147; GO:0042052; GO:0043235; GO:0046716; GO:0072499
GN013643	GN013643.1	Q96LX7	28.8	483	1516	622	1.33e-27	124	CCD17_HUMAN	Coiled-coil domain-containing protein 17	Homo sapiens (Human)			axoneme [GO:0005930]; cilium [GO:0005929]	GO:0005929; GO:0005930
GN013644	GN013644.1	Q9NPF5	52.7	480	476	467	6.07e-153	446	DMAP1_HUMAN	DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of protein import into nucleus [GO:0042307]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; response to ethanol [GO:0045471]	RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000786; GO:0003714; GO:0005634; GO:0005654; GO:0005657; GO:0005737; GO:0005829; GO:0006281; GO:0006338; GO:0006355; GO:0035267; GO:0042307; GO:0042981; GO:0045471; GO:0045892; GO:0045893; GO:0051726; GO:0061629; GO:1905168; GO:2000779
GN013645	GN013645.1	Q9LDD8	47.8	510	561	587	5.22e-148	441	MCCB_ARATH	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)	Arabidopsis thaliana (Mouse-ear cress)	L-leucine catabolic process [GO:0006552]	cobalt ion binding [GO:0050897]; methylcrotonoyl-CoA carboxylase activity [GO:0004485]; zinc ion binding [GO:0008270]	methylcrotonoyl-CoA carboxylase complex [GO:1905202]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0004485; GO:0005739; GO:0005759; GO:0005886; GO:0006552; GO:0008270; GO:0050897; GO:1905202
GN013647	GN013647.1	Q9H3H1	41.2	456	485	467	6.64e-117	354	MOD5_HUMAN	tRNA dimethylallyltransferase (EC 2.5.1.75) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (hGRO1) (tRNA isopentenyltransferase 1) (IPTase)	Homo sapiens (Human)	mitochondrial tRNA modification [GO:0070900]; tRNA modification [GO:0006400]	ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]; tRNA dimethylallyltransferase activity [GO:0052381]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003676; GO:0005524; GO:0005739; GO:0005759; GO:0006400; GO:0008270; GO:0052381; GO:0070900
GN013648	GN013648.1	Q17103	33.8	397	369	407	6.66e-34	132	MYC_ASTRU	Myc protein (c-myc)	Asterias rubens (Common European starfish) (Asterias vulgaris)		DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]	nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0046983
GN013649	GN013649.1	Q96T60	46.6	191	261	521	9.96e-49	171	PNKP_HUMAN	Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]	Homo sapiens (Human)	base-excision repair [GO:0006284]; base-excision repair, gap-filling [GO:0006287]; DNA repair [GO:0006281]; DNA-templated DNA replication [GO:0006261]; double-strand break repair via nonhomologous end joining [GO:0006303]; nucleotide-excision repair [GO:0006289]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of telomere maintenance [GO:0032206]; regulation of DNA repair [GO:0006282]; response to oxidative stress [GO:0006979]; response to radiation [GO:0009314]; single strand break repair [GO:0000012]	ATP binding [GO:0005524]; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; damaged DNA binding [GO:0003684]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; polynucleotide 3'-phosphatase activity [GO:0046403]; purine nucleotide binding [GO:0017076]	chromosome [GO:0005694]; DNA ligase III-XRCC1 complex [GO:0070421]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]	GO:0000012; GO:0003684; GO:0003690; GO:0004519; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0006261; GO:0006281; GO:0006282; GO:0006284; GO:0006287; GO:0006289; GO:0006303; GO:0006979; GO:0009314; GO:0016020; GO:0017076; GO:0032206; GO:0035861; GO:0046403; GO:0046404; GO:0070421; GO:0090734; GO:2001034
GN013651	GN013651.1	Q6DHN0	34.0	288	293	281	1.41e-42	150	TMM53_DANRE	Transmembrane protein 53	Danio rerio (Zebrafish) (Brachydanio rerio)	negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; regulation of nucleocytoplasmic transport [GO:0046822]		nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]	GO:0005640; GO:0030279; GO:0030514; GO:0031965; GO:0045668; GO:0046822
GN013652	GN013652.1	A7MBF6	56.2	281	300	442	8.32e-102	308	ARMD1_BOVIN	Armadillo-like helical domain containing protein 1	Bos taurus (Bovine)				
GN013653	GN013653.1	Q05722	29.2	219	1000	921	3.57e-23	110	CO9A1_MOUSE	Collagen alpha-1(IX) chain	Mus musculus (Mouse)	bone morphogenesis [GO:0060349]; cartilage development [GO:0051216]; chondrocyte proliferation [GO:0035988]; extracellular matrix organization [GO:0030198]; growth plate cartilage development [GO:0003417]; skeletal system development [GO:0001501]; tissue homeostasis [GO:0001894]	carbohydrate binding [GO:0030246]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]; protein homodimerization activity [GO:0042803]	collagen type IX trimer [GO:0005594]; extracellular matrix [GO:0031012]	GO:0001501; GO:0001894; GO:0003417; GO:0005594; GO:0030020; GO:0030198; GO:0030246; GO:0031012; GO:0035988; GO:0042803; GO:0051216; GO:0060349
GN013654	GN013654.1	Q9NUR3	39.7	78	143	256	1.01e-09	58.2	TM74B_HUMAN	Transmembrane protein 74B	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN013655	GN013655.1	B4II37	46.1	958	949	947	6.10e-181	551	SRRT_DROSE	Serrate RNA effector molecule homolog (Arsenite-resistance protein 2 homolog)	Drosophila sechellia (Fruit fly)	defense response to Gram-negative bacterium [GO:0050829]; nuclear RNA surveillance [GO:0071027]; primary miRNA processing [GO:0031053]; regulatory ncRNA-mediated post-transcriptional gene silencing [GO:0035194]; siRNA processing [GO:0030422]	protein-macromolecule adaptor activity [GO:0030674]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]	GO:0005654; GO:0016604; GO:0030422; GO:0030674; GO:0031053; GO:0035194; GO:0050829; GO:0071027
GN013656	GN013656.1	Q3ZCD7	57.6	304	339	308	6.61e-128	371	TECR_BOVIN	Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)	Bos taurus (Bovine)	fatty acid elongation [GO:0030497]; sphingolipid metabolic process [GO:0006665]; very long-chain fatty acid biosynthetic process [GO:0042761]	trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166]; very-long-chain enoyl-CoA reductase activity [GO:0102758]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0006665; GO:0019166; GO:0030497; GO:0042761; GO:0102758
GN013657	GN013657.1	P41340	97.1	376	376	376	2.13e-273	743	ACT3_LIMPO	Actin-3 (EC 3.6.4.-)	Limulus polyphemus (Atlantic horseshoe crab)	anatomical structure formation involved in morphogenesis [GO:0048646]; cell development [GO:0048468]	ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887; GO:0048468; GO:0048646
GN013658	GN013658.1	Q9D5I4	34.7	118	191	173	2.06e-15	73.6	DYLT5_MOUSE	Dynein light chain Tctex-type 5 (Tctex1 domain-containing protein 1)	Mus musculus (Mouse)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505
GN013659	GN013659.1	A2VDD2	36.4	162	226	176	6.94e-26	102	DYL5B_XENLA	Dynein light chain Tctex-type 5-B (Tctex1 domain-containing protein 1-B)	Xenopus laevis (African clawed frog)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505
GN013660	GN013660.1	Q8N7M0	38.5	117	210	179	3.00e-19	84.3	DYLT5_HUMAN	Dynein light chain Tctex-type 5 (Tctex1 domain-containing protein 1)	Homo sapiens (Human)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505
GN013661	GN013661.1	Q66IC8	33.3	120	211	173	1.20e-15	74.7	DYLT5_DANRE	Dynein light chain Tctex-type 5 (Tctex1 domain-containing protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505; GO:0060271
GN013662	GN013662.1	Q13351	81.0	100	415	362	3.17e-22	100	KLF1_HUMAN	Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF)	Homo sapiens (Human)	cellular response to endothelin [GO:1990859]; erythrocyte differentiation [GO:0030218]; maternal process involved in female pregnancy [GO:0060135]; positive regulation of DNA-templated transcription [GO:0045893]; protein destabilization [GO:0031648]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; ubiquitin-dependent protein catabolic process [GO:0006511]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]; ubiquitin binding [GO:0043130]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000976; GO:0000978; GO:0000981; GO:0003700; GO:0005634; GO:0005654; GO:0006355; GO:0006357; GO:0006511; GO:0030218; GO:0031648; GO:0043130; GO:0045893; GO:0060135; GO:1990859
GN013663	GN013663.1	P79818	97.6	374	376	375	1.51e-275	749	ACTB_ORYLA	Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) (OlCA1) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]	Oryzias latipes (Japanese rice fish) (Japanese killifish)		ATP hydrolysis activity [GO:0016887]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; dense body [GO:0097433]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005200; GO:0005634; GO:0005856; GO:0005886; GO:0005925; GO:0015629; GO:0016887; GO:0097433
GN013665	GN013665.1	O17320	83.0	270	294	376	3.29e-161	456	ACT_MAGGI	Actin (EC 3.6.4.-)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN013666	GN013666.1	P79818	81.4	376	377	375	4.99e-224	619	ACTB_ORYLA	Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) (OlCA1) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]	Oryzias latipes (Japanese rice fish) (Japanese killifish)		ATP hydrolysis activity [GO:0016887]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; dense body [GO:0097433]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005200; GO:0005634; GO:0005856; GO:0005886; GO:0005925; GO:0015629; GO:0016887; GO:0097433
GN013668	GN013668.1	P12716	97.6	376	376	376	1.83e-274	746	ACTC_PISOC	Actin, cytoplasmic (EC 3.6.4.-) [Cleaved into: Actin, cytoplasmic, intermediate form]	Pisaster ochraceus (Ochre sea star) (Asterias ochracea)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN013671	GN013671.1	Q25010	92.1	329	329	376	7.29e-223	613	ACT3A_HELAM	Actin, cytoplasmic A3a (EC 3.6.4.-)	Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)	anatomical structure formation involved in morphogenesis [GO:0048646]; cell development [GO:0048468]	ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887; GO:0048468; GO:0048646
GN013672	GN013672.1	P50729	32.1	196	305	496	4.93e-16	81.6	RECS_BACSU	Probable ATP-dependent DNA helicase RecS (EC 5.6.2.4) (Probable DNA 3'-5' helicase RecS) (Recombination protein S)	Bacillus subtilis (strain 168)	DNA recombination [GO:0006310]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]	GO:0003676; GO:0005524; GO:0005694; GO:0005737; GO:0006310; GO:0016887; GO:0030894; GO:0043138; GO:0043590
GN013673	GN013673.1	O17320	97.1	376	376	376	2.60e-274	746	ACT_MAGGI	Actin (EC 3.6.4.-)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN013674	GN013674.1	Q25010	97.6	376	376	376	2.60e-274	746	ACT3A_HELAM	Actin, cytoplasmic A3a (EC 3.6.4.-)	Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)	anatomical structure formation involved in morphogenesis [GO:0048646]; cell development [GO:0048468]	ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887; GO:0048468; GO:0048646
GN013675	GN013675.1	O17320	99.5	376	376	376	4.02e-278	755	ACT_MAGGI	Actin (EC 3.6.4.-)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN013676	GN013676.1	P10984	97.1	376	376	376	9.07e-275	747	ACT2_CAEEL	Actin-2 (EC 3.6.4.-)	Caenorhabditis elegans	cortical actin cytoskeleton organization [GO:0030866]; embryo development ending in birth or egg hatching [GO:0009792]; locomotion [GO:0040011]; meiosis II cytokinesis [GO:0007111]; mitotic cytokinesis [GO:0000281]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]	GO:0000281; GO:0005200; GO:0005524; GO:0005737; GO:0005884; GO:0005938; GO:0007111; GO:0009792; GO:0015629; GO:0016887; GO:0030866; GO:0040011
GN013677	GN013677.1	Q3ZBN6	38.3	115	193	165	9.77e-15	71.6	GA45A_BOVIN	Growth arrest and DNA damage-inducible protein GADD45 alpha	Bos taurus (Bovine)	cellular response to ionizing radiation [GO:0071479]; cellular response to mechanical stimulus [GO:0071260]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of cell cycle [GO:0051726]; signal transduction in response to DNA damage [GO:0042770]	kinase binding [GO:0019900]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0000122; GO:0005634; GO:0005737; GO:0016607; GO:0019900; GO:0042770; GO:0042803; GO:0043065; GO:0043537; GO:0046330; GO:0046982; GO:0051726; GO:0071260; GO:0071479; GO:1900745; GO:2000379
GN013678	GN013678.1	Q3ZBN6	32.9	152	147	165	1.13e-18	80.5	GA45A_BOVIN	Growth arrest and DNA damage-inducible protein GADD45 alpha	Bos taurus (Bovine)	cellular response to ionizing radiation [GO:0071479]; cellular response to mechanical stimulus [GO:0071260]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of cell cycle [GO:0051726]; signal transduction in response to DNA damage [GO:0042770]	kinase binding [GO:0019900]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0000122; GO:0005634; GO:0005737; GO:0016607; GO:0019900; GO:0042770; GO:0042803; GO:0043065; GO:0043537; GO:0046330; GO:0046982; GO:0051726; GO:0071260; GO:0071479; GO:1900745; GO:2000379
GN013679	GN013679.1	Q2KIX1	34.8	112	133	159	1.39e-17	77.0	GA45G_BOVIN	Growth arrest and DNA damage-inducible protein GADD45 gamma	Bos taurus (Bovine)	positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of cell cycle [GO:0051726]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0046330; GO:0051726; GO:1900745
GN013680	GN013680.1	P15287	31.3	428	520	525	1.68e-49	181	AGSA_APLCA	Adenosine deaminase AGSA (EC 3.5.4.4) (Atrial gland-specific antigen) (AGSA) (Mollusk-derived growth factor) (MDGF)	Aplysia californica (California sea hare)	adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103]	adenosine deaminase activity [GO:0004000]	extracellular region [GO:0005576]	GO:0004000; GO:0005576; GO:0006154; GO:0046103
GN013682	GN013682.1	Q5RBL0	50.4	228	303	306	2.68e-71	225	YIPF1_PONAB	Protein YIPF1 (YIP1 family member 1)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	vesicle-mediated transport [GO:0016192]	small GTPase binding [GO:0031267]	Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; late endosome membrane [GO:0031902]; trans-Golgi network [GO:0005802]	GO:0000138; GO:0005797; GO:0005802; GO:0016192; GO:0031267; GO:0031902
GN013686	GN013686.1	P08953	40.6	170	1186	1097	2.82e-24	114	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN013687	GN013687.1	Q9NVE7	56.3	765	776	773	4.35e-305	857	PANK4_HUMAN	4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4)	Homo sapiens (Human)	coenzyme A biosynthetic process [GO:0015937]; pantothenate metabolic process [GO:0015939]	ATP binding [GO:0005524]; phosphatase activity [GO:0016791]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0015937; GO:0015939; GO:0016791
GN013692	GN013692.1	Q80ZJ1	33.9	171	203	183	2.55e-28	107	RAP2A_MOUSE	Ras-related protein Rap-2a (EC 3.6.5.2)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; establishment of protein localization [GO:0045184]; intracellular protein localization [GO:0008104]; negative regulation of cell migration [GO:0030336]; positive regulation of cell migration [GO:0030335]; positive regulation of microvillus assembly [GO:1903698]; positive regulation of protein autophosphorylation [GO:0031954]; Rap protein signal transduction [GO:0032486]; regulation of dendrite morphogenesis [GO:0048814]; regulation of JNK cascade [GO:0046328]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of synapse assembly [GO:0051963]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; endolysosome [GO:0036019]; Golgi apparatus [GO:0005794]; lamellipodium membrane [GO:0031258]; lysosome [GO:0005764]; membrane [GO:0016020]; midbody [GO:0030496]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0000287; GO:0003924; GO:0003925; GO:0005525; GO:0005764; GO:0005794; GO:0005829; GO:0005886; GO:0008104; GO:0016020; GO:0019003; GO:0030036; GO:0030335; GO:0030336; GO:0030496; GO:0031258; GO:0031954; GO:0032486; GO:0036019; GO:0045184; GO:0045202; GO:0046328; GO:0048814; GO:0051963; GO:0055037; GO:0055038; GO:0097060; GO:0098685; GO:0099072; GO:1903698
GN013693	GN013693.1	Q9TZM3	32.1	212	261	2393	4.06e-22	99.0	LRK1_CAEEL	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) (Leucine-rich repeats, ras-like domain, kinase protein 1) (PARK8-related kinase)	Caenorhabditis elegans	axon extension involved in axon guidance [GO:0048846]; intracellular protein localization [GO:0008104]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; synaptic vesicle transport [GO:0048489]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]	GO:0004674; GO:0005524; GO:0005737; GO:0005794; GO:0006979; GO:0008104; GO:0034976; GO:0043025; GO:0048489; GO:0048846; GO:0106310; GO:1902236
GN013694	GN013694.1	Q3UHC2	36.6	123	136	2014	6.13e-17	79.3	LRRK1_MOUSE	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)	Mus musculus (Mouse)	bone resorption [GO:0045453]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; osteoclast development [GO:0036035]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0004674; GO:0005524; GO:0005739; GO:0005829; GO:0005886; GO:0036035; GO:0042802; GO:0045453; GO:0050731; GO:0050732; GO:0090263; GO:0106310; GO:1902533
GN013695	GN013695.1	Q9TZM3	26.7	565	579	2393	2.45e-21	102	LRK1_CAEEL	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) (Leucine-rich repeats, ras-like domain, kinase protein 1) (PARK8-related kinase)	Caenorhabditis elegans	axon extension involved in axon guidance [GO:0048846]; intracellular protein localization [GO:0008104]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; synaptic vesicle transport [GO:0048489]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]	GO:0004674; GO:0005524; GO:0005737; GO:0005794; GO:0006979; GO:0008104; GO:0034976; GO:0043025; GO:0048489; GO:0048846; GO:0106310; GO:1902236
GN013696	GN013696.1	Q02338	37.0	303	369	343	3.02e-61	203	BDH_HUMAN	D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH) (Short chain dehydrogenase/reductase family 9C member 1)	Homo sapiens (Human)	ketone biosynthetic process [GO:0042181]; ketone catabolic process [GO:0042182]	3-hydroxybutyrate dehydrogenase activity [GO:0003858]	matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003858; GO:0005739; GO:0005743; GO:0005759; GO:0042181; GO:0042182; GO:0099617
GN013698	GN013698.1	U3JAG9	44.0	895	1126	1113	2.02e-138	450	CP131_DANRE	Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium assembly [GO:0035735]; Kupffer's vesicle development [GO:0070121]; melanosome transport [GO:0032402]; negative regulation of intracellular protein transport [GO:0090317]; regulation of centrosome duplication [GO:0010824]; sensory perception of light stimulus [GO:0050953]		acrosomal vesicle [GO:0001669]; centriolar satellite [GO:0034451]; chromosome, centromeric region [GO:0000775]; cilium [GO:0005929]; extracellular region [GO:0005576]	GO:0000775; GO:0001669; GO:0005576; GO:0005929; GO:0010824; GO:0032402; GO:0034451; GO:0035721; GO:0035735; GO:0050953; GO:0060271; GO:0060287; GO:0070121; GO:0090317
GN013699	GN013699.1	Q8HY87	30.4	471	531	826	1.29e-55	203	RNZ2_MACFA	Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	mitochondrial tRNA 3'-end processing [GO:1990180]	3'-tRNA processing endoribonuclease activity [GO:0042781]	mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005739; GO:0042645; GO:0042781; GO:1990180
GN013701	GN013701.1	Q9QXV1	69.4	72	394	362	5.49e-21	96.7	CBX8_MOUSE	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (mPc3)	Mus musculus (Mouse)	cellular response to hydrogen peroxide [GO:0070301]; heterochromatin formation [GO:0031507]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA repair [GO:0045739]	chromatin binding [GO:0003682]; histone H3K27me3 reader activity [GO:0061628]; single-stranded RNA binding [GO:0003727]; ubiquitin-protein transferase activator activity [GO:0097027]	chromatin [GO:0000785]; chromosome [GO:0005694]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]	GO:0000122; GO:0000785; GO:0000792; GO:0003682; GO:0003727; GO:0005634; GO:0005654; GO:0005694; GO:0008284; GO:0031507; GO:0031519; GO:0032967; GO:0035102; GO:0045739; GO:0061628; GO:0070301; GO:0097027
GN013702	GN013702.1	Q01177	43.7	245	274	812	6.39e-60	206	PLMN_RAT	Plasminogen [Cleaved into: Plasmin (EC 3.4.21.7); Plasmin heavy chain A; Plasmin light chain B; Angiostatin]	Rattus norvegicus (Rat)	blood coagulation [GO:0007596]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; fibrinolysis [GO:0042730]; labyrinthine layer blood vessel development [GO:0060716]; mononuclear cell migration [GO:0071674]; muscle cell cellular homeostasis [GO:0046716]; myoblast differentiation [GO:0045445]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of fibrinolysis [GO:0051919]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; tissue regeneration [GO:0042246]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]; trophoblast giant cell differentiation [GO:0060707]	apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein antigen binding [GO:1990405]; protein domain specific binding [GO:0019904]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0002020; GO:0004175; GO:0004252; GO:0005102; GO:0005576; GO:0006508; GO:0007596; GO:0009897; GO:0009986; GO:0010812; GO:0016485; GO:0019899; GO:0019900; GO:0019904; GO:0022617; GO:0030163; GO:0030574; GO:0034185; GO:0042246; GO:0042730; GO:0043536; GO:0045445; GO:0046716; GO:0051087; GO:0051918; GO:0051919; GO:0060707; GO:0060716; GO:0071674; GO:0098685; GO:0098978; GO:0099183; GO:1990405
GN013705	GN013705.1	Q91YU8	55.6	270	274	470	1.07e-98	300	SSF1_MOUSE	Suppressor of SWI4 1 homolog (Ssf-1) (Peter Pan homolog)	Mus musculus (Mouse)	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of cell growth by extracellular stimulus [GO:0001560]	rRNA binding [GO:0019843]	nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]	GO:0000463; GO:0001560; GO:0005634; GO:0005730; GO:0019843; GO:0030687
GN013706	GN013706.1	O88278	28.4	331	1061	3313	8.91e-31	135	CELR3_RAT	Cadherin EGF LAG seven-pass G-type receptor 3 (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2)	Rattus norvegicus (Rat)	axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; cell-cell adhesion mediated by cadherin [GO:0044331]; cilium assembly [GO:0060271]; dopaminergic neuron axon guidance [GO:0036514]; homophilic cell-cell adhesion [GO:0007156]; neuron migration [GO:0001764]; regulation of protein localization [GO:0032880]; regulation of protein phosphorylation [GO:0001932]; serotonergic neuron axon guidance [GO:0036515]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]	adherens junction [GO:0005912]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]	GO:0001764; GO:0001932; GO:0004930; GO:0005509; GO:0005886; GO:0005912; GO:0007156; GO:0007409; GO:0007413; GO:0032880; GO:0036514; GO:0036515; GO:0044331; GO:0048787; GO:0060071; GO:0060271; GO:0098839; GO:0098978
GN013707	GN013707.1	B8A5Y1	30.0	477	434	502	2.23e-43	162	ZN488_DANRE	Zinc finger protein 488 (EC 2.1.1.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of DNA-templated transcription [GO:0006355]; spinal cord motor neuron cell fate specification [GO:0021520]		nucleus [GO:0005634]	GO:0005634; GO:0006355; GO:0021520
GN013711	GN013711.1	Q92113	35.2	477	498	509	6.74e-87	279	CP17A_SQUAC	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)	Squalus acanthias (Spiny dogfish)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid biosynthetic process [GO:0006694]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	membrane [GO:0016020]	GO:0004508; GO:0005506; GO:0006694; GO:0016020; GO:0020037; GO:0042446; GO:0042448
GN013712	GN013712.1	P30437	33.7	205	224	514	7.68e-32	124	CP17A_ONCMY	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)	Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid biosynthetic process [GO:0006694]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	membrane [GO:0016020]	GO:0004508; GO:0005506; GO:0006694; GO:0016020; GO:0020037; GO:0042446; GO:0042448
GN013713	GN013713.1	Q3UMF9	35.6	278	282	409	1.27e-52	179	FAXC_MOUSE	Failed axon connections homolog	Mus musculus (Mouse)			membrane [GO:0016020]	GO:0016020
GN013714	GN013714.1	C3ZQF9	41.7	96	143	380	3.05e-15	74.3	QRFPR_BRAFL	QRFP-like peptide receptor	Branchiostoma floridae (Florida lancelet) (Amphioxus)	cellular response to hormone stimulus [GO:0032870]; cellular response to peptide [GO:1901653]; G protein-coupled receptor signaling pathway [GO:0007186]	G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]	plasma membrane [GO:0005886]	GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0032870; GO:1901653
GN013717	GN013717.1	Q501S4	34.1	132	197	254	9.42e-18	81.6	CSKMT_DANRE	Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial (CS-KMT) (EC 2.1.1.-) (Methyltransferase-like protein 12, mitochondrial)	Danio rerio (Zebrafish) (Brachydanio rerio)	peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; peptidyl-lysine trimethylation [GO:0018023]	lysine N-methyltransferase activity [GO:0016278]; protein-lysine N-methyltransferase activity [GO:0016279]	mitochondrion [GO:0005739]	GO:0005739; GO:0016278; GO:0016279; GO:0018023; GO:0018026; GO:0018027
GN013724	GN013724.1	A2A259	25.8	353	411	760	1.78e-37	147	PK2L1_MOUSE	Polycystin-2-like protein 1 (Polycystin-2L1) (Polycystic kidney disease 2-like 1 protein) (Polycystin-2 homolog)	Mus musculus (Mouse)	cellular response to acidic pH [GO:0071468]; cellular response to pH [GO:0071467]; detection of chemical stimulus involved in sensory perception of sour taste [GO:0001581]; detection of chemical stimulus involved in sensory perception of taste [GO:0050912]; detection of mechanical stimulus [GO:0050982]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; potassium ion transmembrane transport [GO:0071805]; protein homotetramerization [GO:0051289]; protein tetramerization [GO:0051262]; response to water [GO:0009415]; sensory perception of sour taste [GO:0050915]; smoothened signaling pathway [GO:0007224]; sodium ion transmembrane transport [GO:0035725]; transmembrane transport [GO:0055085]	alpha-actinin binding [GO:0051393]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-activated cation channel activity [GO:0005227]; calcium-activated potassium channel activity [GO:0015269]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]; pH-gated monoatomic ion channel activity [GO:0160128]; sodium channel activity [GO:0005272]; transmembrane transporter binding [GO:0044325]	actin cytoskeleton [GO:0015629]; calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; ciliary membrane [GO:0060170]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001581; GO:0005227; GO:0005261; GO:0005262; GO:0005272; GO:0005509; GO:0005783; GO:0005829; GO:0005886; GO:0006812; GO:0007224; GO:0008092; GO:0009415; GO:0015269; GO:0015629; GO:0016020; GO:0031410; GO:0034703; GO:0034704; GO:0035725; GO:0042802; GO:0043235; GO:0044325; GO:0050912; GO:0050915; GO:0050982; GO:0051262; GO:0051289; GO:0051371; GO:0051393; GO:0055085; GO:0060170; GO:0071467; GO:0071468; GO:0071805; GO:0097730; GO:0098655; GO:0160128; GO:1990760
GN013725	GN013725.1	Q7TN88	24.8	783	966	2461	5.06e-58	222	PK1L2_MOUSE	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Mus musculus (Mouse)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]	membrane [GO:0016020]	GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN013726	GN013726.1	Q7TN88	23.8	1160	1325	2461	8.08e-88	319	PK1L2_MOUSE	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Mus musculus (Mouse)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]	membrane [GO:0016020]	GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN013742	GN013742.1	Q9VAF5	27.1	299	538	1706	1.77e-13	77.4	CAD99_DROME	Cadherin-99C	Drosophila melanogaster (Fruit fly)	apical protein localization [GO:0045176]; axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion [GO:0016339]; calcium-mediated signaling [GO:0019722]; cell-cell adhesion mediated by cadherin [GO:0044331]; chorion-containing eggshell formation [GO:0007304]; epithelial cell differentiation [GO:0030855]; follicle cell microvillus organization [GO:0032529]; homophilic cell-cell adhesion [GO:0007156]; mucosal immune response [GO:0002385]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; regulation of follicle cell microvillus length [GO:0032533]; sensory perception of sound [GO:0007605]; tube morphogenesis [GO:0035239]; vitelline membrane formation involved in chorion-containing eggshell formation [GO:0007305]	calcium ion binding [GO:0005509]; myosin binding [GO:0017022]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; endosome membrane [GO:0010008]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]	GO:0002385; GO:0005509; GO:0005886; GO:0005902; GO:0005912; GO:0007156; GO:0007304; GO:0007305; GO:0007409; GO:0007605; GO:0010008; GO:0016324; GO:0016339; GO:0017022; GO:0019722; GO:0030855; GO:0031528; GO:0032529; GO:0032533; GO:0035239; GO:0044331; GO:0045176; GO:2000370
GN013743	GN013743.1	Q9VEU1	26.3	194	481	2240	6.24e-11	68.9	CAD89_DROME	Cadherin-89D	Drosophila melanogaster (Fruit fly)	axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005912; GO:0007156; GO:0007409; GO:0016339; GO:0030855; GO:0044331
GN013748	GN013748.1	Q6PFK1	36.0	247	637	953	5.62e-26	117	ZN598_DANRE	E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	ribosome binding [GO:0043022]; ubiquitin protein ligase activity [GO:0061630]	cytosol [GO:0005829]	GO:0005829; GO:0006513; GO:0016567; GO:0043022; GO:0061630; GO:0070534; GO:0072344; GO:1990116
GN013749	GN013749.1	Q13507	36.7	882	1070	921	3.30e-167	519	TRPC3_HUMAN	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (TRP-3) (hTrp-3) (hTrp3)	Homo sapiens (Human)	calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; phototransduction [GO:0007602]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; single fertilization [GO:0007338]	calcium channel activity [GO:0005262]; calcium-activated cation channel activity [GO:0005227]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]	cation channel complex [GO:0034703]; plasma membrane [GO:0005886]	GO:0005227; GO:0005262; GO:0005886; GO:0006816; GO:0007338; GO:0007602; GO:0010524; GO:0015279; GO:0033198; GO:0034703; GO:0051480; GO:0051592; GO:0070588; GO:0070679; GO:1903244
GN013750	GN013750.1	O43301	28.7	579	588	675	3.63e-65	228	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN013751	GN013751.1	O00142	52.4	103	176	265	1.07e-31	117	KITM_HUMAN	Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (2'-deoxyuridine kinase TK2) (EC 2.7.1.74) (Deoxycytidine kinase TK2) (EC 2.7.1.-) (Mt-TK)	Homo sapiens (Human)	deoxycytidine metabolic process [GO:0046092]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleoside salvage [GO:0043097]; thymidine metabolic process [GO:0046104]	ATP binding [GO:0005524]; deoxycytidine kinase activity [GO:0004137]; nucleoside kinase activity [GO:0019206]; thymidine kinase activity [GO:0004797]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004137; GO:0004797; GO:0005524; GO:0005737; GO:0005739; GO:0005759; GO:0006139; GO:0019206; GO:0043097; GO:0046092; GO:0046104
GN013752	GN013752.1	Q5XNR9	24.9	426	927	1097	3.42e-11	71.2	LIFR_CANLF	Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118)	Canis lupus familiaris (Dog) (Canis familiaris)	cytokine-mediated signaling pathway [GO:0019221]	cytokine receptor activity [GO:0004896]	ciliary neurotrophic factor receptor complex [GO:0070110]	GO:0004896; GO:0019221; GO:0070110
GN013753	GN013753.1	Q9BSF4	30.7	166	202	260	2.02e-22	94.4	TIM29_HUMAN	Mitochondrial import inner membrane translocase subunit Tim29 (TIM29)	Homo sapiens (Human)	protein insertion into mitochondrial inner membrane [GO:0045039]	protein-macromolecule adaptor activity [GO:0030674]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]	GO:0005739; GO:0005743; GO:0005758; GO:0030674; GO:0042721; GO:0045039
GN013755	GN013755.1	Q9ESV0	47.2	625	853	857	1.07e-156	483	DDX24_MOUSE	ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24)	Mus musculus (Mouse)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0016887
GN013756	GN013756.1	Q5W7F3	31.9	411	580	693	1.95e-42	165	ATSL_BOMMO	A disintegrin and metalloproteinase with thrombospondin motifs like (ADAMTS-like) (EC 3.4.24.-) (BmADAMTS-like)	Bombyx mori (Silk moth)	instar larval development [GO:0002168]; membrane protein ectodomain proteolysis [GO:0006509]; metamorphosis [GO:0007552]; molting cycle process [GO:0022404]; pupation [GO:0035074]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]		GO:0002168; GO:0004222; GO:0006509; GO:0007552; GO:0008270; GO:0022404; GO:0035074
GN013758	GN013758.1	Q562C4	43.7	119	180	244	4.95e-25	100	TMT1B_RAT	Thiol S-methyltransferase TMT1B (EC 2.1.1.9) (Associated with lipid droplet protein 1) (ALDI) (Methyltransferase-like protein 7B) (Thiol S-methyltransferase METTL7B)	Rattus norvegicus (Rat)		S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; thiol S-methyltransferase activity [GO:0018708]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]	GO:0005789; GO:0005811; GO:0005829; GO:0008757; GO:0018708
GN013760	GN013760.1	P41233	42.3	1338	1366	2261	0.0	995	ABCA1_MOUSE	Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cholesterol [GO:0071397]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endosomal transport [GO:0016197]; export across plasma membrane [GO:0140115]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein metabolic process [GO:0042157]; lysosome organization [GO:0007040]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; phospholipid transport [GO:0015914]; platelet dense granule organization [GO:0060155]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; protein lipidation [GO:0006497]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; regulation of Cdc42 protein signal transduction [GO:0032489]; response to laminar fluid shear stress [GO:0034616]; response to vitamin B3 [GO:0033552]; reverse cholesterol transport [GO:0043691]; signal release [GO:0023061]	ABC-type transporter activity [GO:0140359]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein A-I receptor activity [GO:0034188]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; high-density lipoprotein particle binding [GO:0008035]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transfer activity [GO:0120014]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; sphingolipid floppase activity [GO:0046623]; syntaxin binding [GO:0019905]; transmembrane protein transporter activity [GO:0008320]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	GO:0002790; GO:0005102; GO:0005524; GO:0005768; GO:0005794; GO:0005886; GO:0006497; GO:0006911; GO:0007040; GO:0007186; GO:0007189; GO:0008035; GO:0008203; GO:0008320; GO:0009306; GO:0009897; GO:0009986; GO:0010875; GO:0015914; GO:0016197; GO:0016323; GO:0016887; GO:0019905; GO:0023061; GO:0030139; GO:0030301; GO:0031210; GO:0031267; GO:0032367; GO:0032489; GO:0033344; GO:0033552; GO:0033700; GO:0034185; GO:0034186; GO:0034188; GO:0034380; GO:0034616; GO:0042157; GO:0042158; GO:0042626; GO:0042632; GO:0043691; GO:0045121; GO:0045332; GO:0045335; GO:0046623; GO:0048471; GO:0051117; GO:0055091; GO:0060155; GO:0071222; GO:0071300; GO:0071345; GO:0071397; GO:0071466; GO:0071806; GO:0090108; GO:0090554; GO:0090556; GO:0097708; GO:0120014; GO:0120020; GO:0140115; GO:0140326; GO:0140328; GO:0140359
GN013761	GN013761.1	P41233	37.1	1025	1059	2261	1.13e-200	638	ABCA1_MOUSE	Phospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to cholesterol [GO:0071397]; cellular response to cytokine stimulus [GO:0071345]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cellular response to xenobiotic stimulus [GO:0071466]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endosomal transport [GO:0016197]; export across plasma membrane [GO:0140115]; G protein-coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein metabolic process [GO:0042157]; lysosome organization [GO:0007040]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; phospholipid transport [GO:0015914]; platelet dense granule organization [GO:0060155]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of high-density lipoprotein particle assembly [GO:0090108]; protein lipidation [GO:0006497]; protein secretion [GO:0009306]; protein transmembrane transport [GO:0071806]; regulation of Cdc42 protein signal transduction [GO:0032489]; response to laminar fluid shear stress [GO:0034616]; response to vitamin B3 [GO:0033552]; reverse cholesterol transport [GO:0043691]; signal release [GO:0023061]	ABC-type transporter activity [GO:0140359]; apolipoprotein A-I binding [GO:0034186]; apolipoprotein A-I receptor activity [GO:0034188]; apolipoprotein binding [GO:0034185]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; floppase activity [GO:0140328]; high-density lipoprotein particle binding [GO:0008035]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine floppase activity [GO:0090554]; phosphatidylserine floppase activity [GO:0090556]; phospholipid transfer activity [GO:0120014]; signaling receptor binding [GO:0005102]; small GTPase binding [GO:0031267]; sphingolipid floppase activity [GO:0046623]; syntaxin binding [GO:0019905]; transmembrane protein transporter activity [GO:0008320]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	GO:0002790; GO:0005102; GO:0005524; GO:0005768; GO:0005794; GO:0005886; GO:0006497; GO:0006911; GO:0007040; GO:0007186; GO:0007189; GO:0008035; GO:0008203; GO:0008320; GO:0009306; GO:0009897; GO:0009986; GO:0010875; GO:0015914; GO:0016197; GO:0016323; GO:0016887; GO:0019905; GO:0023061; GO:0030139; GO:0030301; GO:0031210; GO:0031267; GO:0032367; GO:0032489; GO:0033344; GO:0033552; GO:0033700; GO:0034185; GO:0034186; GO:0034188; GO:0034380; GO:0034616; GO:0042157; GO:0042158; GO:0042626; GO:0042632; GO:0043691; GO:0045121; GO:0045332; GO:0045335; GO:0046623; GO:0048471; GO:0051117; GO:0055091; GO:0060155; GO:0071222; GO:0071300; GO:0071345; GO:0071397; GO:0071466; GO:0071806; GO:0090108; GO:0090554; GO:0090556; GO:0097708; GO:0120014; GO:0120020; GO:0140115; GO:0140326; GO:0140328; GO:0140359
GN013762	GN013762.1	Q6DIY8	43.6	181	195	222	6.60e-42	143	M17L2_XENTR	Mpv17-like protein 2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743
GN013764	GN013764.1	Q5R6Y0	47.5	735	749	684	1.12e-211	614	HBS1L_PONAB	HBS1-like protein (EC 3.6.5.-)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome disassembly [GO:0032790]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; Dom34-Hbs1 complex [GO:1990533]	GO:0003924; GO:0005525; GO:0005737; GO:0022626; GO:0032790; GO:0070966; GO:0072344; GO:1990533
GN013765	GN013765.1	A7RWC9	66.1	177	192	203	4.66e-87	257	ITPA_NEMVE	Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.66) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (XTP/dITP diphosphatase)	Nematostella vectensis (Starlet sea anemone)	deoxyribonucleoside triphosphate catabolic process [GO:0009204]; purine nucleoside triphosphate catabolic process [GO:0009146]	dITP diphosphatase activity [GO:0035870]; ITP diphosphatase activity [GO:0036220]; XTP diphosphatase activity [GO:0036222]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0009146; GO:0009204; GO:0035870; GO:0036220; GO:0036222
GN013766	GN013766.1	P08132	50.3	310	321	319	4.38e-94	285	ANXA4_PIG	Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II)	Sus scrofa (Pig)		calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phosphatidylserine binding [GO:0001786]	nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; zymogen granule membrane [GO:0042589]	GO:0001786; GO:0005509; GO:0005544; GO:0005634; GO:0005886; GO:0012506; GO:0042589
GN013769	GN013769.1	Q14686	45.6	103	1647	2063	4.63e-16	88.6	NCOA6_HUMAN	Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)	Homo sapiens (Human)	brain development [GO:0007420]; DNA damage response [GO:0006974]; DNA-templated transcription initiation [GO:0006352]; heart development [GO:0007507]; myeloid cell differentiation [GO:0030099]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to hormone [GO:0009725]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; nuclear estrogen receptor binding [GO:0030331]; nuclear retinoid X receptor binding [GO:0046965]; nuclear thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713]	histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0003682; GO:0003713; GO:0005634; GO:0005654; GO:0005667; GO:0006352; GO:0006974; GO:0007420; GO:0007507; GO:0009725; GO:0019899; GO:0030099; GO:0030331; GO:0035097; GO:0044666; GO:0045893; GO:0045944; GO:0046965; GO:0046966
GN013772	GN013772.1	Q5XUX1	32.7	104	109	458	3.60e-14	70.1	FBXW9_HUMAN	F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9)	Homo sapiens (Human)	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]		cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005829; GO:0019005; GO:0031146
GN013775	GN013775.1	P60324	56.1	57	252	178	1.51e-17	80.9	NANO3_MOUSE	Nanos homolog 3 (NOS-3)	Mus musculus (Mouse)	germ cell development [GO:0007281]; mRNA destabilization [GO:0061157]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of translation [GO:0017148]; oogenesis [GO:0048477]; regulation of cell cycle [GO:0051726]; regulation of translation [GO:0006417]; spermatogenesis [GO:0007283]	enzyme activator activity [GO:0008047]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]	GO:0000932; GO:0003723; GO:0003729; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006417; GO:0007281; GO:0007283; GO:0008047; GO:0008270; GO:0010494; GO:0017148; GO:0048471; GO:0048477; GO:0051726; GO:0061157; GO:2001234
GN013776	GN013776.1	P80108	32.3	353	354	840	1.19e-47	175	PHLD_HUMAN	Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D)	Homo sapiens (Human)	C-terminal protein lipidation [GO:0006501]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to cholesterol [GO:0071397]; cellular response to insulin stimulus [GO:0032869]; cellular response to pH [GO:0071467]; cellular response to triglyceride [GO:0071401]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; complement receptor mediated signaling pathway [GO:0002430]; hematopoietic stem cell migration [GO:0035701]; hematopoietic stem cell migration to bone marrow [GO:0097241]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of triglyceride catabolic process [GO:0010897]; ossification [GO:0001503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein secretion [GO:0009306]; regulation of cellular response to insulin stimulus [GO:1900076]; response to glucose [GO:0009749]; transepithelial transport [GO:0070633]	D-type glycerophospholipase activity [GO:0004630]; GPI anchor phospholipase D activity [GO:0004621]; sodium channel regulator activity [GO:0017080]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]	GO:0001503; GO:0002042; GO:0002062; GO:0002430; GO:0004621; GO:0004630; GO:0005576; GO:0005737; GO:0005765; GO:0006501; GO:0008285; GO:0008286; GO:0009306; GO:0009749; GO:0010595; GO:0010867; GO:0010897; GO:0010907; GO:0010983; GO:0017080; GO:0031012; GO:0032869; GO:0035701; GO:0035774; GO:0043065; GO:0070062; GO:0070633; GO:0071397; GO:0071401; GO:0071466; GO:0071467; GO:0097241; GO:1900076
GN013778	GN013778.1	B6CHA3	62.9	391	410	772	3.61e-178	518	UHRF1_XENLA	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Nuclear zinc finger protein Np95) (XNp95) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Xenopus laevis (African clawed frog)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0006511; GO:0008270; GO:0016567; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013779	GN013779.1	A7E320	65.1	43	80	786	2.57e-12	63.5	UHRF1_BOVIN	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Bos taurus (Bovine)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; response to stress [GO:0006950]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0006511; GO:0006950; GO:0008270; GO:0016567; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013781	GN013781.1	B6CHA3	38.2	131	143	772	2.41e-18	83.6	UHRF1_XENLA	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Nuclear zinc finger protein Np95) (XNp95) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Xenopus laevis (African clawed frog)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0006511; GO:0008270; GO:0016567; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013782	GN013782.1	B6CHA3	62.9	391	410	772	3.61e-178	518	UHRF1_XENLA	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Nuclear zinc finger protein Np95) (XNp95) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Xenopus laevis (African clawed frog)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0006511; GO:0008270; GO:0016567; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013784	GN013784.1	Q15392	63.4	352	422	516	6.39e-163	471	DHC24_HUMAN	Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1)	Homo sapiens (Human)	cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; negative regulation of cell population proliferation [GO:0008285]; Ras protein signal transduction [GO:0007265]; response to hormone [GO:0009725]; skin development [GO:0043588]; tissue development [GO:0009888]	Delta24(24-1) sterol reductase activity [GO:0000246]; Delta24-sterol reductase activity [GO:0050614]; enzyme binding [GO:0019899]; FAD binding [GO:0071949]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; peptide antigen binding [GO:0042605]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0000139; GO:0000246; GO:0005634; GO:0005783; GO:0005789; GO:0006695; GO:0007265; GO:0008285; GO:0009725; GO:0009888; GO:0016020; GO:0016628; GO:0019899; GO:0033489; GO:0033490; GO:0042605; GO:0043588; GO:0050614; GO:0071949
GN013785	GN013785.1	A7E320	39.6	159	217	786	5.69e-25	105	UHRF1_BOVIN	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Bos taurus (Bovine)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; response to stress [GO:0006950]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0006511; GO:0006950; GO:0008270; GO:0016567; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013786	GN013786.1	E7EZF3	69.2	380	386	776	4.50e-170	497	UHRF1_DANRE	E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	animal organ regeneration [GO:0031100]; chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; heterochromatin formation [GO:0031507]; inflammatory response [GO:0006954]; intestinal epithelial structure maintenance [GO:0060729]; lens development in camera-type eye [GO:0002088]; liver development [GO:0001889]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	hemi-methylated DNA-binding [GO:0044729]; histone binding [GO:0042393]; histone H3K14 ubiquitin ligase activity [GO:0140851]; histone H3K18 ubiquitin ligase activity [GO:0140248]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0001889; GO:0002088; GO:0004842; GO:0005634; GO:0005657; GO:0005694; GO:0005737; GO:0006511; GO:0006954; GO:0008270; GO:0016567; GO:0031100; GO:0031507; GO:0042393; GO:0044027; GO:0044729; GO:0060729; GO:0061630; GO:0062072; GO:0140234; GO:0140248; GO:0140851; GO:0141119
GN013790	GN013790.1	A7RWP6	72.0	75	173	448	2.00e-30	117	EIF3E_NEMVE	Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6)	Nematostella vectensis (Starlet sea anemone)	formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	translation initiation factor activity [GO:0003743]	eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]	GO:0001732; GO:0003743; GO:0006413; GO:0016282; GO:0033290; GO:0071540
GN013791	GN013791.1	D2H0Y8	54.5	165	330	359	2.46e-59	197	RN146_AILME	E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)	Ailuropoda melanoleuca (Giant panda)	positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]	poly-ADP-D-ribose binding [GO:0072572]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004842; GO:0005634; GO:0005829; GO:0006511; GO:0008270; GO:0016055; GO:0051865; GO:0061630; GO:0070936; GO:0072572; GO:0090263
GN013792	GN013792.1	Q9NUQ2	38.0	292	298	364	6.17e-74	234	PLCE_HUMAN	1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 5) (1-AGP acyltransferase 5) (1-AGPAT 5) (Lysophosphatidic acid acyltransferase epsilon) (LPAAT-epsilon)	Homo sapiens (Human)	CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phospholipid biosynthetic process [GO:0008654]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphoethanolamine O-acyltransferase activity [GO:0106262]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]	GO:0003841; GO:0005635; GO:0005739; GO:0005741; GO:0005783; GO:0005789; GO:0006654; GO:0008654; GO:0016024; GO:0036149; GO:0106262
GN013796	GN013796.1	D2H0Y8	54.5	165	330	359	2.46e-59	197	RN146_AILME	E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)	Ailuropoda melanoleuca (Giant panda)	positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]	poly-ADP-D-ribose binding [GO:0072572]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004842; GO:0005634; GO:0005829; GO:0006511; GO:0008270; GO:0016055; GO:0051865; GO:0061630; GO:0070936; GO:0072572; GO:0090263
GN013797	GN013797.1	Q3T102	72.8	416	413	445	4.14e-212	593	EIF3E_BOVIN	Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (eIF-3 p48)	Bos taurus (Bovine)	formation of cytoplasmic translation initiation complex [GO:0001732]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; translational initiation [GO:0006413]	translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3e [GO:0071540]; PML body [GO:0016605]	GO:0000184; GO:0001732; GO:0003743; GO:0005829; GO:0005852; GO:0006413; GO:0016282; GO:0016605; GO:0033290; GO:0071540
GN013799	GN013799.1	Q3TYL0	49.6	458	526	540	2.05e-96	305	IQAK1_MOUSE	IQ motif and ankyrin repeat domain-containing protein 1	Mus musculus (Mouse)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN013800	GN013800.1	Q3TYL0	38.5	96	139	540	9.77e-16	75.9	IQAK1_MOUSE	IQ motif and ankyrin repeat domain-containing protein 1	Mus musculus (Mouse)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN013801	GN013801.1	Q5EAE5	53.7	177	223	202	1.41e-62	196	JOS1_BOVIN	Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1)	Bos taurus (Bovine)	protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]	cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0004843; GO:0005829; GO:0005886; GO:0016579
GN013806	GN013806.1	Q8NBH2	25.7	413	445	661	1.77e-19	94.7	KY_HUMAN	Kyphoscoliosis peptidase (EC 3.4.-.-)	Homo sapiens (Human)	muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]	GO:0005737; GO:0005856; GO:0007517; GO:0007528; GO:0030018
GN013812	GN013812.1	P81431	78.5	302	317	378	2.09e-180	506	ADHX_OCTVU	Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284)	Octopus vulgaris (Common octopus)	formaldehyde catabolic process [GO:0046294]	alcohol dehydrogenase (NAD+) activity [GO:0004022]; S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity [GO:0106322]; S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity [GO:0106321]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]	GO:0004022; GO:0005829; GO:0008270; GO:0046294; GO:0106321; GO:0106322
GN013814	GN013814.1	Q8R151	32.8	1703	2112	1909	8.47e-253	802	ZNFX1_MOUSE	NFX1-type zinc finger-containing protein 1 (ATP- dependent RNA translocase ZNFX1) (EC 3.6.4.-) (E3 ubiquitin-protein and -ssRNA ligase ZNFX1) (EC 2.3.2.27)	Mus musculus (Mouse)	activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	helicase activity [GO:0004386]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380]	GO:0002218; GO:0003723; GO:0004386; GO:0005741; GO:0005829; GO:0008270; GO:0010494; GO:0031048; GO:0031380; GO:0042742; GO:0045071; GO:0051607; GO:0061630; GO:0140311; GO:1900226
GN013815	GN013815.1	Q9P2E3	31.3	1733	1777	1918	3.13e-228	728	ZNFX1_HUMAN	NFX1-type zinc finger-containing protein 1 (ATP- dependent RNA translocase ZNFX1) (EC 3.6.4.-) (E3 ubiquitin-protein and -ssRNA ligase ZNFX1) (EC 2.3.2.27)	Homo sapiens (Human)	activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	helicase activity [GO:0004386]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380]	GO:0002218; GO:0003723; GO:0004386; GO:0005741; GO:0005829; GO:0008270; GO:0010494; GO:0031048; GO:0031380; GO:0042742; GO:0045071; GO:0051607; GO:0061630; GO:0140311; GO:1900226
GN013818	GN013818.1	Q80TE7	56.9	58	85	1490	2.96e-14	69.3	LRRC7_MOUSE	Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1)	Mus musculus (Mouse)	cell-cell adhesion [GO:0098609]; clustering of voltage-gated calcium channels [GO:0070073]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of neuron projection development [GO:0010976]; receptor clustering [GO:0043113]; regulation of long-term synaptic depression [GO:1900452]	protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]	actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; axon initial segment [GO:0043194]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density membrane [GO:0098839]	GO:0005737; GO:0005912; GO:0010976; GO:0014069; GO:0015629; GO:0016323; GO:0019901; GO:0030175; GO:0030674; GO:0043113; GO:0043194; GO:0043197; GO:0045197; GO:0070073; GO:0098609; GO:0098839; GO:0098887; GO:0098978; GO:1900452
GN013824	GN013824.1	Q9UDY4	58.1	358	352	337	3.04e-134	389	DNJB4_HUMAN	DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; protein folding [GO:0006457]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]	ATPase activator activity [GO:0001671]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; Z disc [GO:0030018]	GO:0000122; GO:0001671; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006457; GO:0006986; GO:0009408; GO:0030018; GO:0051087
GN013826	GN013826.1	Q8BLA8	31.6	263	290	1125	5.43e-22	99.4	TRPA1_MOUSE	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Wasabi receptor)	Mus musculus (Mouse)	calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to caffeine [GO:0071313]; cellular response to carbon dioxide [GO:0071244]; cellular response to cold [GO:0070417]; cellular response to food [GO:0071240]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to toxic substance [GO:0097237]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of monoatomic anion transport [GO:1903793]; protein homotetramerization [GO:0051289]; regulation of blood circulation [GO:1903522]; regulation of neuronal action potential [GO:0098908]; response to cold [GO:0009409]; response to hydrogen peroxide [GO:0042542]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]; ureteric peristalsis [GO:0072105]; urinary bladder smooth muscle contraction [GO:0014832]; vasodilation [GO:0042311]	calcium channel activity [GO:0005262]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; monoatomic ion channel activity [GO:0005216]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]; temperature-gated cation channel activity [GO:0097604]; voltage-gated calcium channel activity [GO:0005245]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]	GO:0005216; GO:0005245; GO:0005262; GO:0005886; GO:0006816; GO:0006874; GO:0007166; GO:0009409; GO:0009410; GO:0014832; GO:0015267; GO:0015278; GO:0016020; GO:0016324; GO:0019233; GO:0030424; GO:0032421; GO:0034605; GO:0035774; GO:0042311; GO:0042542; GO:0042802; GO:0048265; GO:0050955; GO:0050966; GO:0050968; GO:0050974; GO:0051289; GO:0070301; GO:0070417; GO:0070588; GO:0071240; GO:0071244; GO:0071313; GO:0072105; GO:0097237; GO:0097553; GO:0097604; GO:0098908; GO:1903522; GO:1903793; GO:1990760
GN013830	GN013830.1	Q1HPL8	39.3	150	170	159	3.83e-28	105	NDUBA_BOMMO	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	Bombyx mori (Silk moth)			mitochondrial inner membrane [GO:0005743]; respiratory chain complex I [GO:0045271]	GO:0005743; GO:0045271
GN013831	GN013831.1	Q29293	76.2	395	402	403	3.20e-231	639	RL3_PIG	Large ribosomal subunit protein uL3 (60S ribosomal protein L3)	Sus scrofa (Pig)	cytoplasmic translation [GO:0002181]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]; nucleolus [GO:0005730]	GO:0002181; GO:0003735; GO:0005730; GO:0005737; GO:0006412; GO:0022625
GN013832	GN013832.1	Q5XX13	33.6	702	1247	1052	3.26e-104	358	FBW10_HUMAN	F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor)	Homo sapiens (Human)	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]		cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005829; GO:0019005; GO:0031146
GN013833	GN013833.1	Q5E9S4	59.1	298	336	497	8.82e-114	342	AT2L1_BOVIN	Ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) (Alanine--glyoxylate aminotransferase 2-like 1)	Bos taurus (Bovine)		ethanolamine-phosphate phospho-lyase activity [GO:0050459]; pyridoxal phosphate binding [GO:0030170]	mitochondrion [GO:0005739]	GO:0005739; GO:0030170; GO:0050459
GN013837	GN013837.1	Q5E9A1	68.5	92	117	215	4.43e-26	99.8	NACA_BOVIN	Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC)	Bos taurus (Bovine)	protein targeting to membrane [GO:0006612]	TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; nascent polypeptide-associated complex [GO:0005854]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005737; GO:0005854; GO:0006612; GO:0017025
GN013843	GN013843.1	A0JNC4	58.0	255	267	281	5.70e-104	306	ELOV7_BOVIN	Very long chain fatty acid elongase 7 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL7) (ELOVL fatty acid elongase 7) (ELOVL FA elongase 7) (Elongation of very long chain fatty acids protein 7) (Very long chain 3-ketoacyl-CoA synthase 7) (Very long chain 3-oxoacyl-CoA synthase 7)	Bos taurus (Bovine)	fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]	fatty acid elongase activity [GO:0009922]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0006636; GO:0009922; GO:0019367; GO:0030148; GO:0034625; GO:0034626; GO:0035338; GO:0042761
GN013844	GN013844.1	Q0JRZ9	39.4	904	999	810	1.05e-183	556	FCHO2_HUMAN	F-BAR domain only protein 2	Homo sapiens (Human)	clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; membrane invagination [GO:0010324]; protein localization to plasma membrane [GO:0072659]; synaptic vesicle endocytosis [GO:0048488]	identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]	clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0001786; GO:0005546; GO:0005737; GO:0005829; GO:0005886; GO:0005905; GO:0010324; GO:0030136; GO:0035091; GO:0042802; GO:0048268; GO:0048488; GO:0072583; GO:0072659; GO:0098793
GN013847	GN013847.1	Q9CZU3	67.2	372	546	1040	3.91e-158	481	MTREX_MOUSE	Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; maturation of 5.8S rRNA [GO:0000460]; mRNA metabolic process [GO:0016071]; RNA catabolic process [GO:0006401]; rRNA processing [GO:0006364]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	catalytic step 2 spliceosome [GO:0071013]; nuclear exosome (RNase complex) [GO:0000176]; nuclear exosome targeting complex [GO:0062141]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499]	GO:0000176; GO:0000460; GO:0003723; GO:0003724; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006364; GO:0006401; GO:0006974; GO:0016071; GO:0016607; GO:0016887; GO:0031499; GO:0062141; GO:0071013
GN013848	GN013848.1	H9D1R1	67.5	77	85	173	3.22e-35	120	TXD12_EPICO	Thioredoxin domain-containing protein 12 (EC 1.8.4.2)	Epinephelus coioides (Orange-spotted grouper) (Epinephelus nebulosus)	defense response to virus [GO:0051607]	electron transfer activity [GO:0009055]; protein-disulfide reductase (glutathione) activity [GO:0019153]	endoplasmic reticulum lumen [GO:0005788]	GO:0005788; GO:0009055; GO:0019153; GO:0051607
GN013849	GN013849.1	Q66IC8	41.7	120	200	173	3.10e-26	102	DYLT5_DANRE	Dynein light chain Tctex-type 5 (Tctex1 domain-containing protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505; GO:0060271
GN013852	GN013852.1	Q8BR93	39.6	96	125	349	2.63e-14	70.9	HARB1_MOUSE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Mus musculus (Mouse)			centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005829; GO:0005886; GO:0034451
GN013865	GN013865.1	Q55E58	22.0	463	701	3184	1.31e-14	82.0	PATS1_DICDI	Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1)	Dictyostelium discoideum (Social amoeba)	cheating during chimeric sorocarp development [GO:0099139]; mitotic cytokinesis [GO:0000281]; phosphatidylinositol dephosphorylation [GO:0046856]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actomyosin [GO:0042641]; cytosol [GO:0005829]; membrane [GO:0016020]	GO:0000281; GO:0004438; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0005829; GO:0016020; GO:0042641; GO:0046856; GO:0099139; GO:0106310
GN013867	GN013867.1	P57058	41.5	299	756	714	2.27e-62	225	HUNK_HUMAN	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (B19) (Serine/threonine-protein kinase MAK-V)	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]	GO:0004674; GO:0005524; GO:0005737; GO:0007165; GO:0035556; GO:0106310
GN013878	GN013878.1	Q5ZIN1	48.8	326	427	341	1.79e-85	267	NUDC_CHICK	Nuclear migration protein nudC (Nuclear distribution protein C homolog)	Gallus gallus (Chicken)	mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle organization [GO:0007052]		midbody [GO:0030496]; mitotic spindle [GO:0072686]	GO:0007052; GO:0007080; GO:0030496; GO:0072686
GN013880	GN013880.1	D8VNS7	46.7	120	116	345	3.14e-32	118	FCNV1_CERRY	Ryncolin-1	Cerberus rynchops (Dog-faced water snake)	complement activation, lectin pathway [GO:0001867]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0001867; GO:0003823; GO:0005102; GO:0005576; GO:0097367
GN013882	GN013882.1	Q9UJA9	43.6	390	500	477	1.68e-112	344	ENPP5_HUMAN	Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5) (EC 3.1.-.-)	Homo sapiens (Human)	cell communication [GO:0007154]	hydrolase activity [GO:0016787]; NAD+ diphosphatase activity [GO:0000210]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0000210; GO:0005576; GO:0005886; GO:0007154; GO:0008270; GO:0016787
GN013883	GN013883.1	Q92621	41.6	1669	1783	2012	0.0	1187	NU205_HUMAN	Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205)	Homo sapiens (Human)	nuclear pore complex assembly [GO:0051292]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]	structural constituent of nuclear pore [GO:0017056]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore inner ring [GO:0044611]	GO:0005635; GO:0005643; GO:0005829; GO:0006913; GO:0006999; GO:0016020; GO:0017056; GO:0031965; GO:0034399; GO:0044611; GO:0051292
GN013885	GN013885.1	Q8JHV9	31.8	233	232	401	7.00e-32	123	BIR7A_XENLA	Baculoviral IAP repeat-containing protein 7-A (EC 2.3.2.27) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (RING-type E3 ubiquitin transferase EIAP-A) (XIAP homolog XLX) (XLX)	Xenopus laevis (African clawed frog)	negative regulation of apoptotic process [GO:0043066]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; regulation of cell cycle [GO:0051726]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004869; GO:0005634; GO:0005737; GO:0031398; GO:0043027; GO:0043066; GO:0051726; GO:0051865; GO:0061630
GN013886	GN013886.1	Q9D920	46.8	158	246	195	2.54e-40	140	BORC5_MOUSE	BLOC-1-related complex subunit 5	Mus musculus (Mouse)	axon development [GO:0061564]; lysosome localization [GO:0032418]; mitochondrion organization [GO:0007005]; mRNA transport [GO:0051028]; nervous system development [GO:0007399]; organelle transport along microtubule [GO:0072384]; positive regulation of anterograde synaptic vesicle transport [GO:1903744]; regulation of endosome size [GO:0051036]; regulation of lysosome size [GO:0062196]		axon [GO:0030424]; BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; plus-end kinesin complex [GO:0005873]; synaptic vesicle membrane [GO:0030672]	GO:0005764; GO:0005765; GO:0005873; GO:0005886; GO:0007005; GO:0007399; GO:0016020; GO:0030424; GO:0030672; GO:0032418; GO:0051028; GO:0051036; GO:0061564; GO:0062196; GO:0072384; GO:0098574; GO:0099078; GO:1903744
GN013894	GN013894.1	B0BLT0	57.8	116	129	128	9.60e-40	132	ZN593_XENTR	Zinc finger protein 593	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		nucleic acid binding [GO:0003676]; preribosome binding [GO:1990275]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	GO:0003676; GO:0005730; GO:0005737; GO:0008270; GO:1990275
GN013895	GN013895.1	T1PRE3	19.9	312	447	454	7.58e-09	61.2	JTX2A_CHIFL	Toxin CfTX-A (Toxin A) (TX-A)	Chironex fleckeri (Australian box jellyfish)			extracellular region [GO:0005576]; nematocyst [GO:0042151]	GO:0005576; GO:0042151
GN013896	GN013896.1	Q9GNN8	21.6	310	444	463	1.97e-11	69.3	JTX2A_ALAAL	Toxin CaTX-A (Toxin-A) (CAT-1) (Toxin CaTX-B) (Toxin-B)	Alatina alata (Hawaiian box jellyfish) (Carybdea alata)		toxin activity [GO:0090729]	extracellular region [GO:0005576]; nematocyst [GO:0042151]	GO:0005576; GO:0042151; GO:0090729
GN013899	GN013899.1	O75398	54.0	198	334	565	7.11e-59	201	DEAF1_HUMAN	Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5)	Homo sapiens (Human)	anatomical structure morphogenesis [GO:0009653]; behavioral fear response [GO:0001662]; embryonic skeletal system development [GO:0048706]; germ cell development [GO:0007281]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]; visual learning [GO:0008542]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000785; GO:0000977; GO:0000981; GO:0001227; GO:0001650; GO:0001662; GO:0001843; GO:0005576; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0006366; GO:0007281; GO:0008542; GO:0009653; GO:0033599; GO:0045892; GO:0045893; GO:0048706; GO:0090575
GN013900	GN013900.1	Q9H8Y1	28.1	199	421	702	4.37e-12	71.6	VRTN_HUMAN	Vertnin	Homo sapiens (Human)	regulation of transcription by RNA polymerase II [GO:0006357]	sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0006357; GO:0043565
GN013904	GN013904.1	Q26261	33.0	115	316	947	5.80e-10	63.9	UNC5_CAEEL	Netrin receptor unc-5 (Uncoordinated protein 5)	Caenorhabditis elegans	chemorepulsion of axon [GO:0061643]; commissural neuron axon guidance [GO:0071679]; distal tip cell migration [GO:0097628]; dorsal/ventral axon guidance [GO:0033563]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; gonad morphogenesis [GO:0035262]; mesodermal cell migration [GO:0008078]; motor neuron axon guidance [GO:0008045]; negative regulation of microtubule polymerization [GO:0031115]; nematode male tail tip morphogenesis [GO:0045138]; netrin-activated signaling pathway [GO:0038007]; positive regulation of anterior/posterior axon guidance [GO:1905488]; positive regulation of axon extension [GO:0045773]; positive regulation of locomotion [GO:0040017]; regulation of dorsal/ventral axon guidance [GO:1905815]; ventral cord development [GO:0007419]	netrin receptor activity [GO:0005042]	axonal growth cone [GO:0044295]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0005042; GO:0005886; GO:0007419; GO:0008045; GO:0008078; GO:0030950; GO:0031115; GO:0033563; GO:0035262; GO:0038007; GO:0040017; GO:0044295; GO:0045121; GO:0045138; GO:0045773; GO:0061643; GO:0071679; GO:0097628; GO:1905488; GO:1905815
GN013907	GN013907.1	B3EWZ8	45.5	66	469	400	9.57e-09	60.8	ECT_ACRMI	Ectin	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]	GO:0005576
GN013911	GN013911.1	P46023	37.9	340	969	1115	4.39e-58	221	GR101_LYMST	G protein-coupled receptor GRL101	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; hormone-mediated signaling pathway [GO:0009755]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007189; GO:0008528; GO:0009755
GN013914	GN013914.1	Q5R8X2	41.5	106	172	188	4.39e-21	88.2	DUS18_PONAB	Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	dephosphorylation [GO:0016311]; negative regulation of bone resorption [GO:0045779]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation [GO:0035335]	MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; phosphatase activity [GO:0016791]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; nucleus [GO:0005634]	GO:0004722; GO:0004725; GO:0005634; GO:0005737; GO:0005743; GO:0008138; GO:0016311; GO:0016791; GO:0017017; GO:0035335; GO:0035970; GO:0045779
GN013916	GN013916.1	Q17QM8	51.8	168	193	198	1.58e-55	177	DUS14_BOVIN	Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48)	Bos taurus (Bovine)		MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]	GO:0004722; GO:0004725; GO:0005737; GO:0017017
GN013918	GN013918.1	A5PJY4	58.4	154	161	162	2.08e-54	172	TM138_BOVIN	Transmembrane protein 138	Bos taurus (Bovine)	cilium assembly [GO:0060271]		cilium [GO:0005929]; vacuolar membrane [GO:0005774]	GO:0005774; GO:0005929; GO:0060271
GN013919	GN013919.1	Q9BSJ2	48.6	181	224	902	5.33e-42	154	GCP2_HUMAN	Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97)	Homo sapiens (Human)	brain development [GO:0007420]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; neuron migration [GO:0001764]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225]	gamma-tubulin binding [GO:0043015]	centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; spindle pole [GO:0000922]	GO:0000278; GO:0000922; GO:0000930; GO:0001764; GO:0005813; GO:0005815; GO:0005829; GO:0005881; GO:0007020; GO:0007420; GO:0016020; GO:0043015; GO:0051225; GO:0051321; GO:0065003
GN013920	GN013920.1	Q9BSJ2	64.9	393	454	902	2.62e-183	538	GCP2_HUMAN	Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97)	Homo sapiens (Human)	brain development [GO:0007420]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; neuron migration [GO:0001764]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225]	gamma-tubulin binding [GO:0043015]	centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; spindle pole [GO:0000922]	GO:0000278; GO:0000922; GO:0000930; GO:0001764; GO:0005813; GO:0005815; GO:0005829; GO:0005881; GO:0007020; GO:0007420; GO:0016020; GO:0043015; GO:0051225; GO:0051321; GO:0065003
GN013922	GN013922.1	Q5TB80	35.1	769	1483	1403	1.33e-88	321	CE162_HUMAN	Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog)	Homo sapiens (Human)	cilium assembly [GO:0060271]		axonemal microtubule [GO:0005879]; centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spindle [GO:0005819]	GO:0005654; GO:0005813; GO:0005814; GO:0005819; GO:0005829; GO:0005879; GO:0060271
GN013923	GN013923.1	Q496A3	36.0	172	176	300	5.18e-18	82.4	SPAS1_HUMAN	Spermatogenesis-associated serine-rich protein 1	Homo sapiens (Human)				
GN013926	GN013926.1	Q8CGS6	45.8	166	155	2544	2.42e-35	132	DPOLQ_MOUSE	DNA polymerase theta (Chromosome aberrations occurring spontaneously protein 1) (DNA polymerase eta) [Includes: Helicase POLQ (EC 5.6.2.-); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)]	Mus musculus (Mouse)	base-excision repair [GO:0006284]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; error-prone translesion synthesis [GO:0042276]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein homooligomerization [GO:0051260]; replication fork processing [GO:0031297]; somatic hypermutation of immunoglobulin genes [GO:0016446]	5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA polymerase activity [GO:0034061]; DNA-directed DNA polymerase activity [GO:0003887]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; RNA-directed DNA polymerase activity [GO:0003964]; single-stranded DNA helicase activity [GO:0017116]	chromosome [GO:0005694]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrial nucleoid [GO:0042645]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]	GO:0000287; GO:0003677; GO:0003678; GO:0003682; GO:0003887; GO:0003964; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005794; GO:0005829; GO:0006281; GO:0006284; GO:0006302; GO:0006974; GO:0016446; GO:0016887; GO:0017116; GO:0031297; GO:0034061; GO:0035861; GO:0042276; GO:0042645; GO:0042802; GO:0051260; GO:0051575; GO:0090734; GO:0097681; GO:2000042
GN013927	GN013927.1	O75417	35.5	2445	2369	2590	0.0	1157	DPOLQ_HUMAN	DNA polymerase theta (DNA polymerase eta) [Includes: Helicase POLQ (EC 5.6.2.4); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)]	Homo sapiens (Human)	base-excision repair [GO:0006284]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; error-prone translesion synthesis [GO:0042276]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein homooligomerization [GO:0051260]; replication fork processing [GO:0031297]; somatic hypermutation of immunoglobulin genes [GO:0016446]	3'-5' DNA helicase activity [GO:0043138]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; DNA helicase activity [GO:0003678]; DNA polymerase activity [GO:0034061]; DNA-directed DNA polymerase activity [GO:0003887]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; RNA-directed DNA polymerase activity [GO:0003964]; single-stranded DNA helicase activity [GO:0017116]	chromosome [GO:0005694]; mitochondrial nucleoid [GO:0042645]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]	GO:0000287; GO:0003678; GO:0003682; GO:0003684; GO:0003887; GO:0003964; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0006281; GO:0006284; GO:0006302; GO:0006974; GO:0016446; GO:0016887; GO:0017116; GO:0031297; GO:0034061; GO:0035861; GO:0042276; GO:0042645; GO:0042802; GO:0043138; GO:0051260; GO:0051575; GO:0090734; GO:0097681; GO:2000042
GN013942	GN013942.1	P0AFQ9	29.5	210	834	265	3.13e-12	71.2	YCFH_ECO57	Uncharacterized metal-dependent hydrolase YcfH (EC 3.1.-.-)	Escherichia coli O157:H7		DNA nuclease activity [GO:0004536]; hydrolase activity, acting on ester bonds [GO:0016788]	cytosol [GO:0005829]	GO:0004536; GO:0005829; GO:0016788
GN013947	GN013947.1	P53624	66.2	269	277	667	9.20e-130	385	MA1A1_DROME	Mannosyl-oligosaccharide alpha-1,2-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Mannosidase-1)	Drosophila melanogaster (Fruit fly)	carbohydrate metabolic process [GO:0005975]; ERAD pathway [GO:0036503]; Golgi apparatus N-glycan mannose trimming [GO:1904381]	calcium ion binding [GO:0005509]; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [GO:0004571]	endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]	GO:0000139; GO:0004571; GO:0005509; GO:0005783; GO:0005975; GO:0012505; GO:0036503; GO:1904381
GN013954	GN013954.1	Q55E58	23.2	585	876	3184	5.70e-18	93.6	PATS1_DICDI	Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1)	Dictyostelium discoideum (Social amoeba)	cheating during chimeric sorocarp development [GO:0099139]; mitotic cytokinesis [GO:0000281]; phosphatidylinositol dephosphorylation [GO:0046856]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actomyosin [GO:0042641]; cytosol [GO:0005829]; membrane [GO:0016020]	GO:0000281; GO:0004438; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0005829; GO:0016020; GO:0042641; GO:0046856; GO:0099139; GO:0106310
GN013963	GN013963.1	Q8BJZ4	44.3	273	275	320	6.27e-71	224	RT35_MOUSE	Small ribosomal subunit protein mS35 (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt)	Mus musculus (Mouse)	mitochondrial translation [GO:0032543]	structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; sperm head-tail coupling apparatus [GO:0120212]	GO:0003735; GO:0005739; GO:0005743; GO:0005763; GO:0005829; GO:0032543; GO:0120212
GN013966	GN013966.1	X6R8D5	56.1	41	131	112	2.27e-11	59.7	CMIP3_HUMAN	Ciliary microtubule inner protein 3 (GUCA1A neighbor)	Homo sapiens (Human)				
GN013967	GN013967.1	Q9I8D1	61.2	1262	1246	1276	0.0	1340	MYO6_CHICK	Unconventional myosin-VI (Unconventional myosin-6)	Gallus gallus (Chicken)	actin filament-based movement [GO:0030048]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; endocytosis [GO:0006897]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; intracellular protein transport [GO:0006886]; regulation of secretion [GO:0051046]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; cytoskeletal motor activity [GO:0003774]; plus-end directed microfilament motor activity [GO:0060002]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; filamentous actin [GO:0031941]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; microvillus [GO:0005902]; myosin complex [GO:0016459]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	GO:0001726; GO:0003774; GO:0003779; GO:0005516; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0005884; GO:0005886; GO:0005902; GO:0005905; GO:0005938; GO:0006886; GO:0006897; GO:0015629; GO:0016459; GO:0030048; GO:0030136; GO:0030139; GO:0030175; GO:0030330; GO:0030665; GO:0031410; GO:0031941; GO:0031965; GO:0032587; GO:0042472; GO:0042491; GO:0043531; GO:0048471; GO:0051015; GO:0051046; GO:0060002
GN013969	GN013969.1	Q60610	32.3	365	637	1591	1.73e-46	181	TIAM1_MOUSE	Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)	Mus musculus (Mouse)	activation of GTPase activity [GO:0090630]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cardiac muscle hypertrophy [GO:0003300]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; ephrin receptor signaling pathway [GO:0048013]; neuron projection extension [GO:1990138]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of neuron projection development [GO:0010976]; positive regulation of Schwann cell chemotaxis [GO:1904268]; protein localization to membrane [GO:0072657]; protein-containing complex assembly [GO:0065003]; Rac protein signal transduction [GO:0016601]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of GTPase activity [GO:0043087]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of postsynapse organization [GO:0099175]; small GTPase-mediated signal transduction [GO:0007264]	ephrin receptor binding [GO:0046875]; guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; phospholipid binding [GO:0005543]; receptor tyrosine kinase binding [GO:0030971]	axonal growth cone [GO:0044295]; cell junction [GO:0030054]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; kinocilium [GO:0060091]; main axon [GO:0044304]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; pericentriolar material [GO:0000242]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; somatodendritic compartment [GO:0036477]; synapse [GO:0045202]	GO:0000242; GO:0003300; GO:0005085; GO:0005543; GO:0005654; GO:0005829; GO:0005874; GO:0005886; GO:0005911; GO:0007160; GO:0007264; GO:0008017; GO:0008284; GO:0010717; GO:0010976; GO:0016477; GO:0016601; GO:0019900; GO:0030054; GO:0030335; GO:0030971; GO:0031547; GO:0032587; GO:0035567; GO:0036477; GO:0043025; GO:0043087; GO:0043197; GO:0043507; GO:0044291; GO:0044295; GO:0044304; GO:0045202; GO:0046875; GO:0048013; GO:0050772; GO:0060091; GO:0061003; GO:0061178; GO:0065003; GO:0070372; GO:0072657; GO:0090630; GO:0098978; GO:0099147; GO:0099175; GO:1904268; GO:1904338; GO:1905274; GO:1990138
GN013970	GN013970.1	Q9VCA2	44.8	96	121	548	1.36e-20	89.0	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN013971	GN013971.1	Q9VCA2	37.4	543	547	548	7.16e-99	313	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN013972	GN013972.1	Q9VCA2	37.7	544	548	548	4.17e-105	329	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN013973	GN013973.1	Q9VCA2	56.4	101	127	548	3.46e-27	107	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN013974	GN013974.1	Q9VCA2	41.3	545	555	548	1.22e-131	397	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN013975	GN013975.1	Q9VCA2	43.2	546	530	548	2.03e-140	419	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN013988	GN013988.1	P57436	25.1	255	425	264	8.45e-13	71.6	Y355_BUCAI	Uncharacterized metal-dependent hydrolase BU355 (EC 3.1.-.-)	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)		DNA nuclease activity [GO:0004536]; hydrolase activity, acting on ester bonds [GO:0016788]	cytosol [GO:0005829]	GO:0004536; GO:0005829; GO:0016788
GN013992	GN013992.1	P18173	33.9	561	599	612	1.59e-89	292	DHGL_DROME	Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]	Drosophila melanogaster (Fruit fly)	glucose metabolic process [GO:0006006]; pupal chitin-based cuticle development [GO:0008364]; sperm storage [GO:0046693]	flavin adenine dinucleotide binding [GO:0050660]; glucose dehydrogenase (FAD, quinone) activity [GO:0140762]; oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0006006; GO:0008364; GO:0016491; GO:0046693; GO:0050660; GO:0140762
GN013996	GN013996.1	Q9TUP7	22.3	341	378	444	1.23e-10	66.2	OX2R_CANLF	Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2)	Canis lupus familiaris (Dog) (Canis familiaris)	cellular response to hormone stimulus [GO:0032870]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; glucose homeostasis [GO:0042593]; locomotion [GO:0040011]; neuropeptide signaling pathway [GO:0007218]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]	orexin receptor activity [GO:0016499]	plasma membrane [GO:0005886]	GO:0005886; GO:0007218; GO:0007631; GO:0010840; GO:0016499; GO:0022410; GO:0032870; GO:0040011; GO:0042593; GO:0051480
GN013997	GN013997.1	Q9ESQ4	26.4	212	319	395	1.49e-11	68.2	NMUR2_RAT	Neuromedin-U receptor 2 (NMU-R2) (G protein-coupled receptor FM-4) (FM-4) (G protein-coupled receptor TGR-1) (TGR-1)	Rattus norvegicus (Rat)	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; arachidonate secretion [GO:0050482]; G protein-coupled receptor signaling pathway [GO:0007186]; grooming behavior [GO:0007625]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of sensory perception of pain [GO:0051930]; response to pain [GO:0048265]	G protein-coupled receptor activity [GO:0004930]; neuromedin U binding [GO:0042924]; neuromedin U receptor activity [GO:0001607]; neuropeptide receptor activity [GO:0008188]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001607; GO:0002023; GO:0004930; GO:0005886; GO:0007186; GO:0007193; GO:0007200; GO:0007218; GO:0007625; GO:0008188; GO:0016020; GO:0042924; GO:0048265; GO:0050482; GO:0051930
GN014000	GN014000.1	Q0VC50	43.1	58	96	396	4.26e-09	55.1	RT4I1_BOVIN	NAD(P)H oxidoreductase RTN4IP1, mitochondrial (EC 1.6.5.-) (Reticulon-4-interacting protein 1)	Bos taurus (Bovine)	regulation of dendrite development [GO:0050773]; ubiquinone biosynthetic process [GO:0006744]	NADH dehydrogenase (quinone) (non-electrogenic) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; zinc ion binding [GO:0008270]	mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0005739; GO:0005741; GO:0005759; GO:0006744; GO:0008270; GO:0008753; GO:0050136; GO:0050773
GN014002	GN014002.1	Q5VWW1	35.4	113	176	255	2.71e-12	66.2	C1QL3_HUMAN	Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0097107; GO:0098686; GO:0098978; GO:0099550; GO:0099558; GO:0099645
GN014004	GN014004.1	Q865V0	37.6	489	526	499	3.44e-71	238	CEP57_BOVIN	Centrosomal protein of 57 kDa (Cep57) (Testis-specific protein 57) (Translokin)	Bos taurus (Bovine)	fibroblast growth factor receptor signaling pathway [GO:0008543]	fibroblast growth factor binding [GO:0017134]; gamma-tubulin binding [GO:0043015]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005813; GO:0005874; GO:0008017; GO:0008543; GO:0017134; GO:0042803; GO:0043015
GN014006	GN014006.1	P80022	33.8	207	225	230	1.09e-27	108	RNLE_SOLLC	Extracellular ribonuclease LE (RNase LE) (EC 4.6.1.19)	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)		ribonuclease T2 activity [GO:0033897]; RNA binding [GO:0003723]	extracellular region [GO:0005576]	GO:0003723; GO:0005576; GO:0033897
GN014012	GN014012.1	P24463	32.7	214	440	503	1.05e-24	109	CP3AC_CANLF	Cytochrome P450 3A12 (EC 1.14.14.1) (CYPIIIA12) (Cytochrome P450-PBD-1)	Canis lupus familiaris (Dog) (Canis familiaris)	hormone metabolic process [GO:0042445]; oxidative demethylation [GO:0070989]; progesterone metabolic process [GO:0042448]; steroid metabolic process [GO:0008202]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]	endoplasmic reticulum membrane [GO:0005789]	GO:0004497; GO:0005506; GO:0005789; GO:0008202; GO:0008395; GO:0016712; GO:0020037; GO:0042445; GO:0042448; GO:0050649; GO:0070989
GN014013	GN014013.1	Q9RAH6	31.1	305	325	301	1.89e-38	141	NAT_NOCUT	Isonocardicin synthase (EC 2.5.1.38) (Nocardicin 3-amino-3-carboxypropyltransferase)	Nocardia uniformis subsp. tsuyamanensis		isonocardicin synthase activity [GO:0050007]		GO:0050007
GN014015	GN014015.1	Q9NW08	79.2	1135	1139	1133	0.0	1856	RPC2_HUMAN	DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B)	Homo sapiens (Human)	DNA-templated transcription elongation [GO:0006354]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; snRNA transcription by RNA polymerase III [GO:0042796]; termination of RNA polymerase III transcription [GO:0006386]; transcription by RNA polymerase III [GO:0006383]; transcription initiation at RNA polymerase III promoter [GO:0006384]	5'-3' RNA polymerase activity [GO:0034062]; DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]; DNA/RNA hybrid binding [GO:0071667]; ribonucleoside binding [GO:0032549]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]	GO:0003677; GO:0003899; GO:0005634; GO:0005654; GO:0005666; GO:0005737; GO:0005829; GO:0006354; GO:0006383; GO:0006384; GO:0006386; GO:0008270; GO:0032549; GO:0032728; GO:0034062; GO:0042796; GO:0045089; GO:0071667
GN014016	GN014016.1	Q640M1	40.9	716	739	767	4.47e-123	389	UT14A_MOUSE	U3 small nucleolar RNA-associated protein 14 homolog A (Juvenile spermatogonial depletion-like X-linked protein) (Jsd-like X-linked protein)	Mus musculus (Mouse)	protein localization to nucleolus [GO:1902570]; rRNA processing [GO:0006364]		cytosol [GO:0005829]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]	GO:0005730; GO:0005829; GO:0006364; GO:0032040; GO:1902570
GN014017	GN014017.1	Q9BWV7	53.4	335	835	592	2.08e-125	392	TTLL2_HUMAN	Probable tubulin polyglutamylase TTLL2 (EC 6.-.-.-) (Testis-specific protein NYD-TSPG) (Tubulin--tyrosine ligase-like protein 2)	Homo sapiens (Human)	microtubule cytoskeleton organization [GO:0000226]	tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	ciliary basal body [GO:0036064]	GO:0000226; GO:0015631; GO:0036064; GO:0070740
GN014018	GN014018.1	Q9D572	36.5	455	535	484	2.82e-77	254	UBX11_MOUSE	UBX domain-containing protein 11 (Socius) (UBX domain-containing protein 5)	Mus musculus (Mouse)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ubiquitin binding [GO:0043130]	cytoskeleton [GO:0005856]	GO:0005856; GO:0043130; GO:0043161
GN014019	GN014019.1	Q6V0K7	35.1	97	204	546	4.29e-11	64.7	OIT3_RAT	Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein)	Rattus norvegicus (Rat)	renal system process [GO:0003014]	calcium ion binding [GO:0005509]	cell surface [GO:0009986]; nuclear envelope [GO:0005635]	GO:0003014; GO:0005509; GO:0005635; GO:0009986
GN014020	GN014020.1	P19218	34.9	126	388	530	1.58e-13	75.5	GP2_RAT	Pancreatic secretory granule membrane major glycoprotein GP2 (Glycoprotein 80) (gp80) (Pancreatic zymogen granule membrane protein GP-2)	Rattus norvegicus (Rat)	antigen transcytosis by M cells in mucosal-associated lymphoid tissue [GO:0002412]; neutrophil migration [GO:1990266]	antigen binding [GO:0003823]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; zymogen granule membrane [GO:0042589]	GO:0002412; GO:0003823; GO:0005576; GO:0005768; GO:0005886; GO:0009897; GO:0009986; GO:0016324; GO:0042589; GO:0045121; GO:1990266
GN014024	GN014024.1	Q862Z3	35.3	156	397	642	1.48e-15	82.0	UROM_CANLF	Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]	Canis lupus familiaris (Dog) (Canis familiaris)	antibacterial innate immune response [GO:0140367]; defense response to Gram-negative bacterium [GO:0050829]; neutrophil migration [GO:1990266]	calcium ion binding [GO:0005509]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; extracellular region [GO:0005576]; membrane [GO:0016020]; spindle pole [GO:0000922]	GO:0000922; GO:0005509; GO:0005576; GO:0005929; GO:0009986; GO:0016020; GO:0016323; GO:0016324; GO:0050829; GO:0060170; GO:0140367; GO:1990266
GN014034	GN014034.1	Q8BTP0	32.6	617	584	560	1.35e-57	205	PIGZ_MOUSE	GPI alpha-1,2-mannosyltransferase 4 (EC 2.4.1.-) (GPI mannosyltransferase IV) (GPI-MT-IV) (Phosphatidylinositol-glycan biosynthesis class Z protein) (PIG-Z)	Mus musculus (Mouse)	GPI anchor biosynthetic process [GO:0006506]	alpha-1,2-mannosyltransferase activity [GO:0000026]; dol-P-Man:Man(3)GlcN-acyl-PI alpha-1,2-mannosyltransferase activity [GO:0120565]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0000026; GO:0000030; GO:0005783; GO:0005789; GO:0006506; GO:0120565
GN014041	GN014041.1	Q7KN92	53.5	217	268	403	1.35e-87	269	B4GTA_DROME	Beta1,4-N-acetylgalactosaminyltransferase A (dmGalT) (EC 2.4.1.244) (UDP-GalNAc:betaGlcNAc beta-1,4GalNAc-transferase)	Drosophila melanogaster (Fruit fly)	arthro-series glucosylceramide biosynthetic process [GO:0140269]; carbohydrate metabolic process [GO:0005975]; glycosphingolipid biosynthetic process [GO:0006688]; Golgi apparatus N-glycan diversification [GO:0016258]; neuromuscular junction development [GO:0007528]	acetylgalactosaminyltransferase activity [GO:0008376]; N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005576; GO:0005794; GO:0005975; GO:0006688; GO:0007528; GO:0008376; GO:0016258; GO:0033842; GO:0140269
GN014044	GN014044.1	Q5PQZ7	34.9	169	189	352	3.22e-17	81.3	POPD1_DANRE	Popeye domain-containing protein 1 (Popeye protein 1) (Blood vessel epicardial substance) (BVES) (hBVES)	Danio rerio (Zebrafish) (Brachydanio rerio)	bicellular tight junction assembly [GO:0070830]; cell-cell junction organization [GO:0045216]; epiboly [GO:0090504]; epithelial cell-cell adhesion [GO:0090136]; epithelium development [GO:0060429]; establishment of skin barrier [GO:0061436]; eye photoreceptor cell development [GO:0042462]; heart contraction [GO:0060047]; heart development [GO:0007507]; heart looping [GO:0001947]; outflow tract morphogenesis [GO:0003151]; positive regulation of locomotion [GO:0040017]; positive regulation of receptor recycling [GO:0001921]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of membrane potential [GO:0042391]; response to ischemia [GO:0002931]; retina development in camera-type eye [GO:0060041]; retina layer formation [GO:0010842]; skeletal muscle tissue development [GO:0007519]; skeletal myofibril assembly [GO:0014866]; striated muscle cell differentiation [GO:0051146]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle-mediated transport [GO:0016192]	cAMP binding [GO:0030552]; structural molecule activity [GO:0005198]	bicellular tight junction [GO:0005923]; caveola [GO:0005901]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	GO:0001921; GO:0001947; GO:0002931; GO:0003151; GO:0005198; GO:0005886; GO:0005901; GO:0005923; GO:0007507; GO:0007519; GO:0008360; GO:0010842; GO:0014866; GO:0016020; GO:0016192; GO:0016328; GO:0030552; GO:0034446; GO:0040017; GO:0042383; GO:0042391; GO:0042462; GO:0043087; GO:0045216; GO:0051146; GO:0060041; GO:0060047; GO:0060429; GO:0061436; GO:0070830; GO:0090136; GO:0090504; GO:0098901
GN014047	GN014047.1	Q6NRS1	44.2	965	1297	1339	4.31e-266	796	IBTK_XENLA	Inhibitor of Bruton tyrosine kinase (IBtk)	Xenopus laevis (African clawed frog)	release of sequestered calcium ion into cytosol [GO:0051209]	protein kinase binding [GO:0019901]; protein tyrosine kinase inhibitor activity [GO:0030292]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0016020; GO:0019901; GO:0030292; GO:0051209
GN014051	GN014051.1	Q13490	29.5	352	1182	618	6.97e-37	152	BIRC2_HUMAN	Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)	Homo sapiens (Human)	canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; response to bleomycin [GO:1904975]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; FBXO family protein binding [GO:0098770]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transcription coactivator activity [GO:0003713]; transferase activity [GO:0016740]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; survivin complex [GO:1990713]; tumor necrosis factor receptor superfamily complex [GO:0002947]; XY body [GO:0001741]	GO:0000209; GO:0001666; GO:0001741; GO:0002947; GO:0003713; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006954; GO:0007166; GO:0007249; GO:0008270; GO:0008625; GO:0008630; GO:0009898; GO:0016740; GO:0031398; GO:0033209; GO:0034121; GO:0035631; GO:0038061; GO:0039535; GO:0042127; GO:0042802; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043130; GO:0043161; GO:0044877; GO:0045088; GO:0045471; GO:0045595; GO:0050727; GO:0051087; GO:0051591; GO:0051726; GO:0060544; GO:0060546; GO:0061630; GO:0070266; GO:0070424; GO:0098770; GO:1902523; GO:1902524; GO:1902527; GO:1904975; GO:1990713
GN014053	GN014053.1	Q13490	28.9	339	1475	618	2.42e-32	138	BIRC2_HUMAN	Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)	Homo sapiens (Human)	canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; response to bleomycin [GO:1904975]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; FBXO family protein binding [GO:0098770]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transcription coactivator activity [GO:0003713]; transferase activity [GO:0016740]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; survivin complex [GO:1990713]; tumor necrosis factor receptor superfamily complex [GO:0002947]; XY body [GO:0001741]	GO:0000209; GO:0001666; GO:0001741; GO:0002947; GO:0003713; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006954; GO:0007166; GO:0007249; GO:0008270; GO:0008625; GO:0008630; GO:0009898; GO:0016740; GO:0031398; GO:0033209; GO:0034121; GO:0035631; GO:0038061; GO:0039535; GO:0042127; GO:0042802; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043130; GO:0043161; GO:0044877; GO:0045088; GO:0045471; GO:0045595; GO:0050727; GO:0051087; GO:0051591; GO:0051726; GO:0060544; GO:0060546; GO:0061630; GO:0070266; GO:0070424; GO:0098770; GO:1902523; GO:1902524; GO:1902527; GO:1904975; GO:1990713
GN014056	GN014056.1	Q9VCA2	35.9	393	420	548	6.36e-84	270	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN014060	GN014060.1	Q03460	53.3	2052	1999	2194	0.0	2103	GLSN_MEDSA	Glutamate synthase [NADH], amyloplastic (EC 1.4.1.14) (NADH-GOGAT)	Medicago sativa (Alfalfa)	ammonia assimilation cycle [GO:0019676]; developmental growth [GO:0048589]; L-glutamate biosynthetic process [GO:0097054]	flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; glutamate synthase (NADH) activity [GO:0016040]; iron ion binding [GO:0005506]; iron-sulfur cluster binding [GO:0051536]; oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [GO:0016639]	amyloplast [GO:0009501]	GO:0005506; GO:0009501; GO:0010181; GO:0016040; GO:0016639; GO:0019676; GO:0048589; GO:0050660; GO:0051536; GO:0097054
GN014061	GN014061.1	A0A2B4RNI3	29.3	174	673	688	6.19e-17	88.6	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014062	GN014062.1	A0A2B4RNI3	30.6	222	612	688	4.50e-20	98.2	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014063	GN014063.1	P91621	39.9	253	610	2072	1.64e-40	162	SIF1_DROME	Protein still life, isoform SIF type 1	Drosophila melanogaster (Fruit fly)	actin cytoskeleton organization [GO:0030036]; eye development [GO:0001654]; positive regulation of axonogenesis [GO:0050772]; positive regulation of filopodium assembly [GO:0051491]; regulation of axonogenesis [GO:0050770]; regulation of synapse structure or activity [GO:0050803]; small GTPase-mediated signal transduction [GO:0007264]; visual perception [GO:0007601]	guanyl-nucleotide exchange factor activity [GO:0005085]	membrane [GO:0016020]; synapse [GO:0045202]	GO:0001654; GO:0005085; GO:0007264; GO:0007601; GO:0016020; GO:0030036; GO:0045202; GO:0050770; GO:0050772; GO:0050803; GO:0051491
GN014064	GN014064.1	P70057	59.5	548	577	652	1.36e-198	573	KCNQ1_XENLA	Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha xKvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)	Xenopus laevis (African clawed frog)	inner ear development [GO:0048839]; intestinal absorption [GO:0050892]; membrane repolarization [GO:0086009]; potassium ion transmembrane transport [GO:0071805]; regulation of gastric acid secretion [GO:0060453]; renal absorption [GO:0070293]	delayed rectifier potassium channel activity [GO:0005251]; outward rectifier potassium channel activity [GO:0015271]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; voltage-gated potassium channel activity [GO:0005249]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; membrane raft [GO:0045121]; monoatomic ion channel complex [GO:0034702]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]	GO:0005249; GO:0005251; GO:0005546; GO:0005737; GO:0005783; GO:0005886; GO:0008076; GO:0015271; GO:0016323; GO:0030659; GO:0034702; GO:0045121; GO:0048839; GO:0050892; GO:0060453; GO:0070293; GO:0071805; GO:0086009
GN014065	GN014065.1	Q4PJX1	34.5	406	452	447	1.45e-70	233	ODR4_MOUSE	Protein odr-4 homolog (mODR-4)	Mus musculus (Mouse)	intracellular protein localization [GO:0008104]		membrane [GO:0016020]	GO:0008104; GO:0016020
GN014066	GN014066.1	Q52KI8	65.7	143	1100	946	2.00e-47	187	SRRM1_MOUSE	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101)	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing, via transesterification reactions [GO:0000375]		catalytic step 2 spliceosome [GO:0071013]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681]; U12-type catalytic step 2 spliceosome [GO:0071018]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0000375; GO:0000398; GO:0005681; GO:0016363; GO:0016607; GO:0048024; GO:0071006; GO:0071013; GO:0071018
GN014068	GN014068.1	Q55E58	23.1	411	815	3184	7.37e-19	96.3	PATS1_DICDI	Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1)	Dictyostelium discoideum (Social amoeba)	cheating during chimeric sorocarp development [GO:0099139]; mitotic cytokinesis [GO:0000281]; phosphatidylinositol dephosphorylation [GO:0046856]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actomyosin [GO:0042641]; cytosol [GO:0005829]; membrane [GO:0016020]	GO:0000281; GO:0004438; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0005829; GO:0016020; GO:0042641; GO:0046856; GO:0099139; GO:0106310
GN014069	GN014069.1	Q93099	71.5	432	445	445	7.64e-242	669	HGD_HUMAN	Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase)	Homo sapiens (Human)	L-phenylalanine catabolic process [GO:0006559]; L-tyrosine catabolic process [GO:0006572]	homogentisate 1,2-dioxygenase activity [GO:0004411]; identical protein binding [GO:0042802]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0004411; GO:0005829; GO:0006559; GO:0006572; GO:0042802; GO:0070062
GN014081	GN014081.1	P34456	32.2	87	143	419	2.92e-09	57.4	YMD2_CAEEL	Uncharacterized protein F54H12.2	Caenorhabditis elegans	deoxyribonucleotide biosynthetic process [GO:0009263]	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]	cytosol [GO:0005829]	GO:0004748; GO:0005829; GO:0009263
GN014093	GN014093.1	O73770	51.7	172	221	200	3.64e-46	154	DGCR6_CHICK	Protein DGCR6 (DiGeorge syndrome critical region 6 homolog)	Gallus gallus (Chicken)				
GN014096	GN014096.1	O45782	29.6	314	349	426	2.07e-32	128	ARD17_CAEEL	Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1)	Caenorhabditis elegans		molecular adaptor activity [GO:0060090]; protein phosphatase 2B binding [GO:0030346]	cytoplasm [GO:0005737]	GO:0005737; GO:0030346; GO:0060090
GN014109	GN014109.1	Q61045	68.5	289	596	765	2.18e-125	390	SIM1_MOUSE	Single-minded homolog 1 (mSIM1)	Mus musculus (Mouse)	regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; ureteric bud development [GO:0001657]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0001657; GO:0005634; GO:0006355; GO:0006357; GO:0046982
GN014112	GN014112.1	A9ULZ2	47.2	89	266	345	2.57e-21	94.7	BIR7B_XENLA	Baculoviral IAP repeat-containing protein 7-B (EC 2.3.2.27) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) (RING-type E3 ubiquitin transferase EIAP-B)	Xenopus laevis (African clawed frog)	negative regulation of apoptotic process [GO:0043066]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; regulation of cell cycle [GO:0051726]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004869; GO:0005634; GO:0005737; GO:0031398; GO:0043027; GO:0043066; GO:0051726; GO:0051865; GO:0061630
GN014114	GN014114.1	Q17QR8	29.2	281	393	349	1.97e-25	108	HARB1_BOVIN	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Bos taurus (Bovine)			cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005829; GO:0005886
GN014115	GN014115.1	Q6IRN2	49.7	376	369	342	5.25e-103	310	QKIB_XENLA	KH domain-containing RNA-binding protein qki.L (Protein quaking-B)	Xenopus laevis (African clawed frog)	negative regulation of macrophage differentiation [GO:0045650]; regulation of astrocyte differentiation [GO:0048710]; regulation of mRNA splicing, via spliceosome [GO:0048024]; spliceosome-depend formation of circular RNA [GO:0160091]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003729; GO:0005634; GO:0005737; GO:0045650; GO:0048024; GO:0048710; GO:0160091
GN014116	GN014116.1	Q7Z2Y8	27.6	486	474	2422	1.35e-30	129	GVIN1_HUMAN	Interferon-induced very large GTPase 1 (Interferon-induced very large GTPase pseudogene 1)	Homo sapiens (Human)		GTP binding [GO:0005525]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005525; GO:0005634; GO:0005829
GN014124	GN014124.1	Q55E58	22.7	493	982	3184	5.28e-22	107	PATS1_DICDI	Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1)	Dictyostelium discoideum (Social amoeba)	cheating during chimeric sorocarp development [GO:0099139]; mitotic cytokinesis [GO:0000281]; phosphatidylinositol dephosphorylation [GO:0046856]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actomyosin [GO:0042641]; cytosol [GO:0005829]; membrane [GO:0016020]	GO:0000281; GO:0004438; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0005829; GO:0016020; GO:0042641; GO:0046856; GO:0099139; GO:0106310
GN014126	GN014126.1	Q9R0N7	69.9	73	129	403	1.87e-28	110	SYT7_MOUSE	Synaptotagmin-7 (Synaptotagmin VII) (SytVII)	Mus musculus (Mouse)	calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; calcium-ion regulated exocytosis [GO:0017156]; insulin secretion [GO:0030073]; phagocytosis [GO:0006909]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of bone remodeling [GO:0046850]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of phagocytosis [GO:0050764]; regulation of synaptic vesicle endocytosis [GO:1900242]; short-term synaptic potentiation [GO:1990926]; synaptic vesicle recycling [GO:0036465]; vesicle fusion [GO:0006906]; vesicle-mediated cholesterol transport [GO:0090119]; vesicle-mediated transport [GO:0016192]	calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]	axon [GO:0030424]; axon terminus [GO:0043679]; cytosol [GO:0005829]; dendrite [GO:0030425]; dense core granule [GO:0031045]; early phagosome [GO:0032009]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	GO:0000149; GO:0001778; GO:0001786; GO:0005509; GO:0005516; GO:0005544; GO:0005546; GO:0005764; GO:0005765; GO:0005777; GO:0005778; GO:0005829; GO:0005886; GO:0006906; GO:0006909; GO:0008021; GO:0014059; GO:0016192; GO:0017156; GO:0017158; GO:0019905; GO:0030073; GO:0030276; GO:0030424; GO:0030425; GO:0030670; GO:0030672; GO:0031045; GO:0032009; GO:0036465; GO:0042734; GO:0043025; GO:0043679; GO:0045202; GO:0045956; GO:0046850; GO:0048791; GO:0050764; GO:0050796; GO:0061891; GO:0070092; GO:0090119; GO:0090385; GO:0098686; GO:0098978; GO:0098982; GO:0099502; GO:1900242; GO:1990926; GO:1990927
GN014127	GN014127.1	Q55E58	24.2	521	1225	3184	1.48e-16	89.7	PATS1_DICDI	Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1)	Dictyostelium discoideum (Social amoeba)	cheating during chimeric sorocarp development [GO:0099139]; mitotic cytokinesis [GO:0000281]; phosphatidylinositol dephosphorylation [GO:0046856]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actomyosin [GO:0042641]; cytosol [GO:0005829]; membrane [GO:0016020]	GO:0000281; GO:0004438; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0005829; GO:0016020; GO:0042641; GO:0046856; GO:0099139; GO:0106310
GN014130	GN014130.1	B4JSC2	58.5	294	661	630	3.38e-88	291	FOXO_DROGR	Forkhead box protein O	Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)	cellular response to oxidative stress [GO:0034599]; determination of adult lifespan [GO:0008340]; glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of catabolic process [GO:0009896]; positive regulation of defense response [GO:0031349]; positive regulation of immune response [GO:0050778]; regulation of DNA-templated transcription [GO:0006355]; regulation of lipid metabolic process [GO:0019216]; regulation of lipid storage [GO:0010883]; response to starvation [GO:0042594]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0003700; GO:0005634; GO:0005737; GO:0006355; GO:0008285; GO:0008286; GO:0008340; GO:0009896; GO:0010883; GO:0019216; GO:0030308; GO:0031349; GO:0034599; GO:0040015; GO:0042593; GO:0042594; GO:0046627; GO:0050778
GN014133	GN014133.1	P32019	45.1	736	832	993	9.53e-208	618	I5P2_HUMAN	Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (EC 3.1.3.56) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)	Homo sapiens (Human)	inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol dephosphorylation [GO:0046856]; signal transduction [GO:0007165]	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity [GO:0052659]; inositol-1,4,5-trisphosphate 5-phosphatase activity [GO:0052658]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuron projection [GO:0043005]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	GO:0004439; GO:0005737; GO:0005793; GO:0005794; GO:0005829; GO:0005886; GO:0007165; GO:0016020; GO:0030670; GO:0031901; GO:0043005; GO:0043647; GO:0046856; GO:0052658; GO:0052659
GN014146	GN014146.1	Q55E58	22.2	554	780	3184	7.09e-15	83.2	PATS1_DICDI	Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1)	Dictyostelium discoideum (Social amoeba)	cheating during chimeric sorocarp development [GO:0099139]; mitotic cytokinesis [GO:0000281]; phosphatidylinositol dephosphorylation [GO:0046856]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actomyosin [GO:0042641]; cytosol [GO:0005829]; membrane [GO:0016020]	GO:0000281; GO:0004438; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0005829; GO:0016020; GO:0042641; GO:0046856; GO:0099139; GO:0106310
GN014151	GN014151.1	Q5UPX0	28.1	235	255	548	1.66e-18	87.8	YR290_MIMIV	Putative ATP-dependent RNA helicase R290 (EC 3.6.4.13)	Acanthamoeba polyphaga mimivirus (APMV)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]		GO:0003676; GO:0003724; GO:0005524; GO:0006260; GO:0006281; GO:0006310; GO:0016887; GO:0043138
GN014153	GN014153.1	Q0VCJ7	42.0	162	210	199	2.59e-37	131	RERG_BOVIN	Ras-related and estrogen-regulated growth inhibitor (EC 3.6.5.2)	Bos taurus (Bovine)	establishment or maintenance of cell polarity [GO:0007163]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; Ras protein signal transduction [GO:0007265]; response to hormone [GO:0009725]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005525; GO:0005634; GO:0005829; GO:0005886; GO:0007163; GO:0007265; GO:0008285; GO:0009725; GO:0030308
GN014154	GN014154.1	A9ULZ2	34.9	152	216	345	2.32e-17	82.4	BIR7B_XENLA	Baculoviral IAP repeat-containing protein 7-B (EC 2.3.2.27) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) (RING-type E3 ubiquitin transferase EIAP-B)	Xenopus laevis (African clawed frog)	negative regulation of apoptotic process [GO:0043066]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; regulation of cell cycle [GO:0051726]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004869; GO:0005634; GO:0005737; GO:0031398; GO:0043027; GO:0043066; GO:0051726; GO:0051865; GO:0061630
GN014163	GN014163.1	P41366	40.4	193	195	183	1.12e-39	136	VMO1_CHICK	Vitelline membrane outer layer protein 1 (VMO-1) (VMO-I) (VMOI)	Gallus gallus (Chicken)			extracellular region [GO:0005576]	GO:0005576
GN014170	GN014170.1	Q96MM6	34.3	632	576	686	2.82e-111	350	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN014171	GN014171.1	Q24307	27.6	181	203	498	3.20e-15	76.6	DIAP2_DROME	Death-associated inhibitor of apoptosis 2 (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2)	Drosophila melanogaster (Fruit fly)	chaeta development [GO:0022416]; defense response to Gram-negative bacterium [GO:0050829]; negative regulation of apoptotic process [GO:0043066]; peptidoglycan recognition protein signaling pathway [GO:0061057]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0006964]; positive regulation of protein ubiquitination [GO:0031398]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; ubiquitin-dependent protein catabolic process [GO:0006511]	caspase binding [GO:0089720]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; cysteine-type endopeptidase regulator activity involved in apoptotic process [GO:0043028]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005829; GO:0006511; GO:0006964; GO:0008270; GO:0016567; GO:0022416; GO:0031398; GO:0031625; GO:0043027; GO:0043028; GO:0043066; GO:0048471; GO:0050829; GO:0051726; GO:0061057; GO:0061630; GO:0070534; GO:0070936; GO:0089720
GN014180	GN014180.1	P49135	75.6	702	740	783	0.0	1052	ERCC3_MOUSE	General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH 89 kDa subunit) (Xeroderma pigmentosum group B-complementing protein)	Mus musculus (Mouse)	apoptotic process [GO:0006915]; DNA repair [GO:0006281]; DNA topological change [GO:0006265]; embryonic organ development [GO:0048568]; hair cell differentiation [GO:0035315]; intracellular protein localization [GO:0008104]; nucleotide-excision repair [GO:0006289]; positive regulation of apoptotic process [GO:0043065]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; transcription by RNA polymerase II [GO:0006366]; transcription elongation by RNA polymerase I [GO:0006362]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]; UV protection [GO:0009650]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; promoter-specific chromatin binding [GO:1990841]	nucleoplasm [GO:0005654]; nucleotide-excision repair factor 3 complex [GO:0000112]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription preinitiation complex [GO:0097550]	GO:0000112; GO:0000439; GO:0003677; GO:0005524; GO:0005654; GO:0005669; GO:0005675; GO:0006265; GO:0006281; GO:0006283; GO:0006289; GO:0006362; GO:0006366; GO:0006367; GO:0006915; GO:0006979; GO:0008104; GO:0009411; GO:0009650; GO:0016887; GO:0035315; GO:0043065; GO:0043138; GO:0048568; GO:0097550; GO:1901990; GO:1990841
GN014181	GN014181.1	Q6AZB8	31.6	114	152	349	2.89e-10	60.5	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN014183	GN014183.1	P10155	50.9	55	100	538	2.25e-10	58.9	RO60_HUMAN	RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2)	Homo sapiens (Human)	cellular response to interferon-alpha [GO:0035457]; regulation of gene expression [GO:0010468]; transcription by RNA polymerase III [GO:0006383]	RNA binding [GO:0003723]; U2 snRNA binding [GO:0030620]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005634; GO:0005737; GO:0005829; GO:0006383; GO:0010468; GO:0030620; GO:0035457; GO:1990904
GN014184	GN014184.1	Q27274	35.9	131	167	643	2.05e-16	79.0	RO60_CAEEL	RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein homolog)	Caenorhabditis elegans		RNA binding [GO:0003723]	cytoplasm [GO:0005737]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005737; GO:1990904
GN014189	GN014189.1	P42700	36.5	567	589	538	1.40e-101	321	RO60_XENLA	RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2)	Xenopus laevis (African clawed frog)		misfolded RNA binding [GO:0034336]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005737; GO:0034336; GO:1990904
GN014191	GN014191.1	P42700	36.4	558	587	538	6.20e-99	314	RO60_XENLA	RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2)	Xenopus laevis (African clawed frog)		misfolded RNA binding [GO:0034336]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005737; GO:0034336; GO:1990904
GN014192	GN014192.1	Q24307	26.1	314	602	498	2.28e-28	122	DIAP2_DROME	Death-associated inhibitor of apoptosis 2 (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2)	Drosophila melanogaster (Fruit fly)	chaeta development [GO:0022416]; defense response to Gram-negative bacterium [GO:0050829]; negative regulation of apoptotic process [GO:0043066]; peptidoglycan recognition protein signaling pathway [GO:0061057]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0006964]; positive regulation of protein ubiquitination [GO:0031398]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; ubiquitin-dependent protein catabolic process [GO:0006511]	caspase binding [GO:0089720]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; cysteine-type endopeptidase regulator activity involved in apoptotic process [GO:0043028]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005829; GO:0006511; GO:0006964; GO:0008270; GO:0016567; GO:0022416; GO:0031398; GO:0031625; GO:0043027; GO:0043028; GO:0043066; GO:0048471; GO:0050829; GO:0051726; GO:0061057; GO:0061630; GO:0070534; GO:0070936; GO:0089720
GN014193	GN014193.1	A5D8Q0	29.1	175	258	488	3.53e-14	75.1	XIAP_XENLA	E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (xXIAP)	Xenopus laevis (African clawed frog)	negative regulation of apoptotic process [GO:0043066]; negative regulation of proteolysis [GO:0045861]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein ubiquitination [GO:0031398]; regulation of cell cycle [GO:0051726]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004842; GO:0005634; GO:0005737; GO:0031398; GO:0043027; GO:0043066; GO:0043123; GO:0045861; GO:0051726; GO:0061630; GO:0070431; GO:0090263; GO:1902530
GN014199	GN014199.1	Q86Z23	29.1	117	178	238	3.00e-10	60.5	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN014203	GN014203.1	Q86YQ8	34.8	546	607	564	9.89e-92	296	CPNE8_HUMAN	Copine-8 (Copine VIII)	Homo sapiens (Human)	cellular response to calcium ion [GO:0071277]; positive regulation of dendrite extension [GO:1903861]	calcium-dependent phospholipid binding [GO:0005544]	extracellular exosome [GO:0070062]	GO:0005544; GO:0070062; GO:0071277; GO:1903861
GN014204	GN014204.1	Q8BR93	42.1	95	133	349	3.41e-14	70.9	HARB1_MOUSE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Mus musculus (Mouse)			centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005829; GO:0005886; GO:0034451
GN014205	GN014205.1	Q9Y385	69.1	188	500	318	3.86e-85	268	UB2J1_HUMAN	Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e)	Homo sapiens (Human)	ERAD pathway [GO:0036503]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein N-linked glycosylation [GO:0006487]; protein polyubiquitination [GO:0000209]	ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]	endoplasmic reticulum membrane [GO:0005789]; Hrd1p ubiquitin ligase complex [GO:0000836]	GO:0000209; GO:0000836; GO:0005789; GO:0006487; GO:0031625; GO:0036503; GO:0061631; GO:1904153
GN014206	GN014206.1	A0A2B4RNI3	32.7	162	663	688	5.57e-20	98.2	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014207	GN014207.1	A0A2B4RNI3	32.5	163	644	688	5.77e-22	104	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014208	GN014208.1	A0A2B4RNI3	33.1	163	680	688	8.87e-22	103	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014209	GN014209.1	Q91WL8	36.0	311	325	414	3.43e-41	151	WWOX_MOUSE	WW domain-containing oxidoreductase (EC 1.1.1.-)	Mus musculus (Mouse)	cellular response to transforming growth factor beta stimulus [GO:0071560]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of Wnt signaling pathway [GO:0030178]; osteoblast differentiation [GO:0001649]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal system morphogenesis [GO:0048705]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; microvillus [GO:0005902]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0001649; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005764; GO:0005794; GO:0005829; GO:0005886; GO:0005902; GO:0019899; GO:0030178; GO:0042802; GO:0045944; GO:0048705; GO:0071560; GO:0072332; GO:0090575; GO:0097191; GO:2001238; GO:2001241
GN014210	GN014210.1	Q8N5I4	37.3	295	318	330	5.86e-44	156	DHRSX_HUMAN	Polyprenol dehydrogenase (EC 1.1.1.441) (DHRSXY) (Dehydrogenase/reductase SDR family member on chromosome X) (Dolichal reductase)	Homo sapiens (Human)	dolichyl monophosphate biosynthetic process [GO:0043048]; positive regulation of autophagy [GO:0010508]	alcohol dehydrogenase (NADP+) activity [GO:0008106]; dolichal reductase (NADPH) activity [GO:0160197]; polyprenol dehydrogenase (NAD+) activity [GO:0160196]	endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]	GO:0005576; GO:0005789; GO:0005811; GO:0008106; GO:0010508; GO:0043048; GO:0160196; GO:0160197
GN014211	GN014211.1	Q91WL8	37.6	322	637	414	2.59e-43	164	WWOX_MOUSE	WW domain-containing oxidoreductase (EC 1.1.1.-)	Mus musculus (Mouse)	cellular response to transforming growth factor beta stimulus [GO:0071560]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of Wnt signaling pathway [GO:0030178]; osteoblast differentiation [GO:0001649]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal system morphogenesis [GO:0048705]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; microvillus [GO:0005902]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0001649; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005764; GO:0005794; GO:0005829; GO:0005886; GO:0005902; GO:0019899; GO:0030178; GO:0042802; GO:0045944; GO:0048705; GO:0071560; GO:0072332; GO:0090575; GO:0097191; GO:2001238; GO:2001241
GN014212	GN014212.1	Q6PEI7	70.5	586	609	591	2.12e-308	851	PYRG1_DANRE	CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (Protein-asparagine deamidase CTPS1) (EC 3.5.1.-) (UTP--ammonia ligase 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	'de novo' CTP biosynthetic process [GO:0044210]; CTP biosynthetic process [GO:0006241]; DNA repair-dependent chromatin remodeling [GO:0140861]; negative regulation of chromosome condensation [GO:1902340]; negative regulation of type I interferon production [GO:0032480]; notochord development [GO:0030903]; pyrimidine nucleobase biosynthetic process [GO:0019856]	CTP synthase activity [GO:0003883]; histone H1N76/N77 asparagine deamidase activity [GO:0160264]; identical protein binding [GO:0042802]; protein asparagine deamidase activity [GO:0160260]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoophidium [GO:0097268]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000785; GO:0003883; GO:0005634; GO:0005694; GO:0005737; GO:0005829; GO:0006241; GO:0019856; GO:0030903; GO:0032480; GO:0042802; GO:0044210; GO:0097268; GO:0140861; GO:0160260; GO:0160264; GO:1902340
GN014214	GN014214.1	A0A2B4RNI3	33.9	168	631	688	2.95e-21	102	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014216	GN014216.1	A6QR56	42.2	819	834	800	1.68e-211	621	A16A1_BOVIN	Aldehyde dehydrogenase family 16 member A1	Bos taurus (Bovine)	aldehyde metabolic process [GO:0006081]	aldehyde dehydrogenase (NAD+) activity [GO:0004029]		GO:0004029; GO:0006081
GN014217	GN014217.1	Q8N3L3	50.3	304	744	684	1.75e-73	255	TXLNB_HUMAN	Beta-taxilin (Muscle-derived protein 77) (hMDP77)	Homo sapiens (Human)			cytoplasm [GO:0005737]	GO:0005737
GN014218	GN014218.1	Q9UBI9	35.5	504	499	543	4.37e-87	280	HDC_HUMAN	Headcase protein homolog (hHDC)	Homo sapiens (Human)	negative regulation of mitotic cell cycle [GO:0045930]; respiratory tube development [GO:0030323]; stress granule assembly [GO:0034063]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005737; GO:0010494; GO:0016020; GO:0030323; GO:0034063; GO:0045930
GN014219	GN014219.1	A0A2B4RNI3	25.4	448	532	688	9.11e-28	121	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014220	GN014220.1	A4IHY1	32.8	287	273	287	1.66e-43	152	PSMG1_XENTR	Proteasome assembly chaperone 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	chaperone-mediated protein complex assembly [GO:0051131]; proteasome assembly [GO:0043248]		cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]	GO:0005737; GO:0005783; GO:0043248; GO:0051131
GN014223	GN014223.1	Q90XB3	74.0	73	207	298	1.50e-25	103	OLIG2_CHICK	Oligodendrocyte transcription factor 2 (Oligo2)	Gallus gallus (Chicken)	axon development [GO:0061564]; myelination [GO:0042552]; oligodendrocyte cell fate specification [GO:0021778]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; HMG box domain binding [GO:0071837]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0005737; GO:0007423; GO:0021778; GO:0042552; GO:0042802; GO:0045944; GO:0046983; GO:0061564; GO:0070888; GO:0071837
GN014224	GN014224.1	Q23157	21.7	373	419	465	1.24e-16	85.1	INX11_CAEEL	Innexin-11 (Protein opu-11)	Caenorhabditis elegans		gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005921; GO:0055077
GN014225	GN014225.1	Q23157	22.8	391	419	465	7.18e-21	97.8	INX11_CAEEL	Innexin-11 (Protein opu-11)	Caenorhabditis elegans		gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005921; GO:0055077
GN014227	GN014227.1	F1QMY1	38.3	115	158	150	2.06e-22	90.1	DYT2B_DANRE	Dynein light chain Tctex-type protein 2B (Tctex1 domain-containing protein 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	intraciliary retrograde transport [GO:0035721]; microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; dynein axonemal particle [GO:0120293]	GO:0005737; GO:0005868; GO:0005929; GO:0007018; GO:0035721; GO:0045505; GO:0120293
GN014228	GN014228.1	Q988C9	59.2	71	114	543	5.71e-16	75.5	4PADH_RHILO	4-pyridoxate dehydrogenase (EC 1.1.99.42) (4-pyridoxic acid dehydrogenase) (4-PADH)	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))	vitamin B6 catabolic process [GO:0042820]	alkan-1-ol dehydrogenase (acceptor) activity [GO:0047645]; flavin adenine dinucleotide binding [GO:0050660]	plasma membrane [GO:0005886]	GO:0005886; GO:0042820; GO:0047645; GO:0050660
GN014229	GN014229.1	P18172	40.7	578	610	625	2.26e-128	394	DHGL_DROPS	Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]	Drosophila pseudoobscura pseudoobscura (Fruit fly)		flavin adenine dinucleotide binding [GO:0050660]; glucose dehydrogenase (FAD, quinone) activity [GO:0140762]	extracellular region [GO:0005576]	GO:0005576; GO:0050660; GO:0140762
GN014230	GN014230.1	P36633	28.6	761	1005	746	2.19e-64	235	AOC1_RAT	Diamine oxidase [copper-containing] (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase)	Rattus norvegicus (Rat)	putrescine metabolic process [GO:0009445]	calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; diamine oxidase activity [GO:0052597]; heparin binding [GO:0008201]; histamine oxidase activity [GO:0052598]; primary methylamine oxidase activity [GO:0008131]; protein homodimerization activity [GO:0042803]; putrescine oxidase activity [GO:0050232]; quinone binding [GO:0048038]	bicellular tight junction [GO:0005923]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005507; GO:0005509; GO:0005576; GO:0005886; GO:0005923; GO:0008131; GO:0008201; GO:0009445; GO:0042803; GO:0048038; GO:0050232; GO:0052597; GO:0052598; GO:0070062
GN014231	GN014231.1	A8E4N3	66.4	318	400	606	1.98e-129	388	RSPH3_BOVIN	Radial spoke head protein 3 homolog (A-kinase anchor protein RSPH3) (Radial spoke head-like protein 2)	Bos taurus (Bovine)			9+2 motile cilium [GO:0097729]; cilium [GO:0005929]; radial spoke head [GO:0001535]	GO:0001535; GO:0005929; GO:0097729
GN014232	GN014232.1	Q9H4Q3	85.4	89	436	707	2.26e-48	179	PRD13_HUMAN	PR domain zinc finger protein 13 (EC 2.1.1.-) (PR domain-containing protein 13)	Homo sapiens (Human)	GABAergic neuron differentiation [GO:0097154]; hypothalamus cell differentiation [GO:0021979]; regulation of gene expression [GO:0010468]	chromatin binding [GO:0003682]; histone methyltransferase activity [GO:0042054]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	nucleus [GO:0005634]	GO:0003682; GO:0005634; GO:0010468; GO:0021979; GO:0042054; GO:0061629; GO:0097154
GN014233	GN014233.1	Q8N8K9	24.5	237	729	716	3.31e-11	70.5	K1958_HUMAN	Uncharacterized protein KIAA1958	Homo sapiens (Human)				
GN014234	GN014234.1	A1L209	50.9	171	246	367	1.14e-44	156	AT7L3_DANRE	Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]	DUBm complex [GO:0071819]; SAGA complex [GO:0000124]	GO:0000124; GO:0003713; GO:0006357; GO:0008270; GO:0045893; GO:0071819
GN014236	GN014236.1	Q6QDP7	38.1	430	604	521	2.96e-51	187	CR3L2_RAT	Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (SCI-related protein Ra69) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2]	Rattus norvegicus (Rat)	cartilage development [GO:0051216]; chondrocyte differentiation [GO:0002062]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]	cAMP response element binding [GO:0035497]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear endoplasmic reticulum [GO:0097038]	GO:0000785; GO:0000976; GO:0000978; GO:0000981; GO:0001228; GO:0002062; GO:0005634; GO:0005654; GO:0005783; GO:0005789; GO:0006357; GO:0006888; GO:0010628; GO:0010976; GO:0034976; GO:0035497; GO:0045893; GO:0045944; GO:0051216; GO:0097038
GN014242	GN014242.1	Q9CXP4	52.8	369	503	425	8.24e-126	376	RHG08_MOUSE	Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8)	Mus musculus (Mouse)	negative regulation of endocytic recycling [GO:2001136]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; small GTPase-mediated signal transduction [GO:0007264]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane bounded cell projection [GO:0120025]	GO:0005096; GO:0005737; GO:0007264; GO:0016020; GO:0070374; GO:0120025; GO:2001136
GN014243	GN014243.1	P35761	29.2	828	1268	856	9.71e-79	281	TTK_MOUSE	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT)	Mus musculus (Mouse)	chromosome segregation [GO:0007059]; female meiosis chromosome segregation [GO:0016321]; meiotic spindle assembly checkpoint signaling [GO:0033316]; mitotic spindle assembly checkpoint signaling [GO:0007094]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peptidyl-tyrosine phosphorylation [GO:0018108]; protein autophosphorylation [GO:0046777]; protein localization to chromosome [GO:0034502]; protein localization to kinetochore [GO:0034501]; protein localization to meiotic spindle midzone [GO:1903096]; repair of mitotic kinetochore microtubule attachment defect [GO:0140273]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinetochore binding [GO:0043515]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; kinetochore [GO:0000776]; membrane [GO:0016020]	GO:0000776; GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005737; GO:0007059; GO:0007094; GO:0016020; GO:0016321; GO:0018105; GO:0018107; GO:0018108; GO:0033316; GO:0034501; GO:0034502; GO:0042802; GO:0043515; GO:0046777; GO:0106310; GO:0140273; GO:1903096
GN014249	GN014249.1	A6MEY4	34.6	127	265	145	6.65e-16	75.9	PA2B_BUNFA	Basic phospholipase A2 BFPA (svPLA2) (EC 3.1.1.4) (Antimicrobial phospholipase A2) (Phosphatidylcholine 2-acylhydrolase)	Bungarus fasciatus (Banded krait) (Pseudoboa fasciata)	arachidonate secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644]	A2-type glycerophospholipase activity [GO:0004623]; calcium ion binding [GO:0005509]; phospholipid binding [GO:0005543]	extracellular region [GO:0005576]	GO:0004623; GO:0005509; GO:0005543; GO:0005576; GO:0006644; GO:0016042; GO:0050482
GN014250	GN014250.1	A0A2B4RNI3	33.1	163	647	688	3.95e-20	98.6	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014251	GN014251.1	Q60598	68.6	561	532	546	2.67e-41	159	SRC8_MOUSE	Src substrate cortactin	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; cell migration [GO:0016477]; cell motility [GO:0048870]; dendritic spine maintenance [GO:0097062]; focal adhesion assembly [GO:0048041]; intracellular protein transport [GO:0006886]; lamellipodium organization [GO:0097581]; modification of postsynaptic actin cytoskeleton [GO:0098885]; modification of postsynaptic structure [GO:0099010]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of chemotaxis [GO:0050921]; positive regulation of smooth muscle contraction [GO:0045987]; receptor-mediated endocytosis [GO:0006898]; regulation of actin filament polymerization [GO:0030833]; regulation of axon extension [GO:0030516]; regulation of cell projection assembly [GO:0060491]; regulation of mitophagy [GO:1901524]; substrate-dependent cell migration, cell extension [GO:0006930]	actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; profilin binding [GO:0005522]; proline-rich region binding [GO:0070064]	actin filament [GO:0005884]; anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cell junction [GO:0030054]; clathrin-coated pit [GO:0005905]; cortical actin cytoskeleton [GO:0030864]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; mitotic spindle midzone [GO:1990023]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynapse [GO:0098794]; postsynaptic actin cytoskeleton [GO:0098871]; ruffle [GO:0001726]; site of polarized growth [GO:0030427]; voltage-gated potassium channel complex [GO:0008076]	GO:0001726; GO:0002102; GO:0005522; GO:0005737; GO:0005783; GO:0005794; GO:0005829; GO:0005884; GO:0005886; GO:0005905; GO:0005925; GO:0005938; GO:0006886; GO:0006898; GO:0006930; GO:0008076; GO:0016477; GO:0030027; GO:0030036; GO:0030054; GO:0030426; GO:0030427; GO:0030516; GO:0030833; GO:0030838; GO:0030863; GO:0030864; GO:0043197; GO:0045987; GO:0048041; GO:0048812; GO:0048870; GO:0050921; GO:0051015; GO:0060491; GO:0070064; GO:0070161; GO:0071933; GO:0097062; GO:0097581; GO:0098794; GO:0098871; GO:0098885; GO:0098978; GO:0099010; GO:1901524; GO:1990023; GO:2001237
GN014253	GN014253.1	Q6NVU6	44.4	216	248	218	1.98e-54	177	UFSP1_HUMAN	Ufm1-specific protease 1 (UfSP1) (EC 3.4.22.-)	Homo sapiens (Human)	protein maturation [GO:0051604]; protein ufmylation [GO:0071569]	cysteine-type peptidase activity [GO:0008234]; deUFMylase activity [GO:0071567]	cytosol [GO:0005829]	GO:0005829; GO:0008234; GO:0051604; GO:0071567; GO:0071569
GN014254	GN014254.1	Q0V8T7	45.1	82	330	1305	9.33e-13	72.8	CTP5C_MOUSE	Contactin-associated protein like 5-3 (Cell recognition molecule Caspr5-3) (Cell recognition molecule Caspr5c) (Contactin-associated protein-like 5c)	Mus musculus (Mouse)	nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; retina homeostasis [GO:0001895]; signal transduction [GO:0007165]		fibrillar center [GO:0001650]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0001650; GO:0001895; GO:0005886; GO:0007165; GO:0007399; GO:0030182; GO:0043005; GO:0045202
GN014255	GN014255.1	Q08431	28.7	209	359	387	8.76e-12	69.3	MFGM_HUMAN	Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin]	Homo sapiens (Human)	apoptotic cell clearance [GO:0043277]	integrin binding [GO:0005178]; phosphatidylserine binding [GO:0001786]	acrosomal membrane [GO:0002080]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; membrane [GO:0016020]; non-collagenous component of basement membrane [GO:0140144]	GO:0001786; GO:0002080; GO:0005178; GO:0005576; GO:0005788; GO:0009897; GO:0016020; GO:0031012; GO:0043277; GO:0070062; GO:0140144; GO:1903561
GN014256	GN014256.1	Q0V8T8	38.2	152	358	1292	3.18e-20	95.9	CTP5B_MOUSE	Contactin-associated protein like 5-2 (Cell recognition molecule Caspr5-2) (Cell recognition molecule Caspr5b) (Contactin-associated protein-like 5b)	Mus musculus (Mouse)	nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; retina homeostasis [GO:0001895]; signal transduction [GO:0007165]		fibrillar center [GO:0001650]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0001650; GO:0001895; GO:0005886; GO:0007165; GO:0007399; GO:0030182; GO:0043005; GO:0045202
GN014257	GN014257.1	Q0V8T8	31.4	153	358	1292	5.49e-11	67.8	CTP5B_MOUSE	Contactin-associated protein like 5-2 (Cell recognition molecule Caspr5-2) (Cell recognition molecule Caspr5b) (Contactin-associated protein-like 5b)	Mus musculus (Mouse)	nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; retina homeostasis [GO:0001895]; signal transduction [GO:0007165]		fibrillar center [GO:0001650]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0001650; GO:0001895; GO:0005886; GO:0007165; GO:0007399; GO:0030182; GO:0043005; GO:0045202
GN014262	GN014262.1	Q9TWL9	44.2	52	159	77	2.88e-11	59.3	COMA_CONMA	Conodipine-M alpha chain (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Phospholipase A2) (PLA2)	Conus magus (Magical cone)	arachidonate secretion [GO:0050482]; phospholipid metabolic process [GO:0006644]	A2-type glycerophospholipase activity [GO:0004623]	extracellular region [GO:0005576]	GO:0004623; GO:0005576; GO:0006644; GO:0050482
GN014270	GN014270.1	Q91V92	72.4	1102	1098	1091	0.0	1592	ACLY_MOUSE	ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme)	Mus musculus (Mouse)	acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA metabolic process [GO:0006084]; acyl-CoA biosynthetic process [GO:0071616]; citrate metabolic process [GO:0006101]; coenzyme A metabolic process [GO:0015936]; fatty acid biosynthetic process [GO:0006633]; lipid biosynthetic process [GO:0008610]; malonyl-CoA biosynthetic process [GO:2001295]; negative regulation of ferroptosis [GO:0110076]; oxaloacetate metabolic process [GO:0006107]	ATP citrate synthase activity [GO:0003878]	ATP-dependent citrate lyase complex [GO:0140615]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; sperm principal piece [GO:0097228]	GO:0003878; GO:0005654; GO:0005739; GO:0005829; GO:0006084; GO:0006085; GO:0006101; GO:0006107; GO:0006633; GO:0008610; GO:0015936; GO:0035869; GO:0036064; GO:0071616; GO:0097228; GO:0110076; GO:0140615; GO:2001295
GN014273	GN014273.1	V5NAL9	29.1	484	509	899	8.70e-61	218	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN014275	GN014275.1	V5NAL9	28.0	557	528	899	1.06e-65	232	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN014276	GN014276.1	P46023	36.3	325	900	1115	4.48e-54	207	GR101_LYMST	G protein-coupled receptor GRL101	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; hormone-mediated signaling pathway [GO:0009755]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007189; GO:0008528; GO:0009755
GN014280	GN014280.1	Q63046	55.0	189	252	450	8.60e-57	190	RUNX1_RAT	Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B)	Rattus norvegicus (Rat)	behavioral response to pain [GO:0048266]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system development [GO:0007417]; chondrocyte differentiation [GO:0002062]; definitive hemopoiesis [GO:0060216]; embryonic hemopoiesis [GO:0035162]; hair follicle morphogenesis [GO:0031069]; hemopoiesis [GO:0030097]; in utero embryonic development [GO:0001701]; liver development [GO:0001889]; myeloid cell differentiation [GO:0030099]; myeloid leukocyte differentiation [GO:0002573]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; ossification [GO:0001503]; positive regulation of angiogenesis [GO:0045766]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of cell maturation [GO:1903431]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of progesterone secretion [GO:2000872]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type II interferon production [GO:0032729]; regulation of cell differentiation [GO:0045595]; regulation of DNA-templated transcription [GO:0006355]; regulation of hair follicle cell proliferation [GO:0071336]; regulation of signal transduction [GO:0009966]; regulation of T cell anergy [GO:0002667]; regulation of transcription by RNA polymerase II [GO:0006357]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to retinoic acid [GO:0032526]; skeletal system development [GO:0001501]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; promoter-specific chromatin binding [GO:1990841]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]	basement membrane [GO:0005604]; chromatin [GO:0000785]; core-binding factor complex [GO:0016513]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0001222; GO:0001223; GO:0001228; GO:0001501; GO:0001503; GO:0001701; GO:0001889; GO:0002062; GO:0002318; GO:0002573; GO:0002667; GO:0003677; GO:0003700; GO:0005509; GO:0005524; GO:0005604; GO:0005634; GO:0005654; GO:0006355; GO:0006357; GO:0007417; GO:0008285; GO:0009966; GO:0014894; GO:0016513; GO:0030097; GO:0030099; GO:0030182; GO:0030853; GO:0030854; GO:0031069; GO:0032526; GO:0032729; GO:0032743; GO:0035162; GO:0042803; GO:0043371; GO:0043378; GO:0045595; GO:0045766; GO:0045892; GO:0045893; GO:0045944; GO:0046982; GO:0048266; GO:0048663; GO:0048666; GO:0060216; GO:0071336; GO:0071560; GO:0140297; GO:1903431; GO:1990837; GO:1990841; GO:2000872
GN014281	GN014281.1	Q9SR22	32.6	344	436	427	2.29e-54	189	PAE5_ARATH	Pectin acetylesterase 5 (EC 3.1.1.-)	Arabidopsis thaliana (Mouse-ear cress)		hydrolase activity [GO:0016787]	extracellular region [GO:0005576]	GO:0005576; GO:0016787
GN014282	GN014282.1	V5NAL9	31.5	596	561	899	4.23e-85	286	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN014283	GN014283.1	V5NAL9	31.9	602	577	899	1.75e-86	290	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN014284	GN014284.1	V5NAL9	25.1	602	427	899	1.43e-51	189	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN014289	GN014289.1	Q98943	33.6	122	225	424	2.68e-10	62.8	CASP2_CHICK	Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]	Gallus gallus (Chicken)	apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]	cysteine-type endopeptidase activity [GO:0004197]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]; endopeptidase complex [GO:1905369]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0004197; GO:0005634; GO:0005737; GO:0005739; GO:0006915; GO:0008630; GO:0016485; GO:0019904; GO:0030330; GO:0042802; GO:0043525; GO:0071260; GO:0097192; GO:1905369
GN014296	GN014296.1	Q1JPJ2	44.2	645	672	623	3.34e-160	478	XPP1_BOVIN	Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)	Bos taurus (Bovine)	bradykinin catabolic process [GO:0010815]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]	aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]	cytosol [GO:0005829]	GO:0004177; GO:0005829; GO:0006508; GO:0010815; GO:0030145; GO:0043069; GO:0070006
GN014297	GN014297.1	Q9P802	37.0	108	387	194	1.23e-13	72.4	MIS18_SCHPO	Kinetochore protein mis18	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	CENP-A containing chromatin assembly [GO:0034080]	zinc ion binding [GO:0008270]	CENP-A recruiting complex [GO:0098654]; chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleus [GO:0005634]	GO:0000775; GO:0000776; GO:0000785; GO:0005634; GO:0005737; GO:0008270; GO:0034080; GO:0098654
GN014301	GN014301.1	A4IFU7	45.2	126	495	317	3.34e-20	94.7	TFEC_BOVIN	Transcription factor EC	Bos taurus (Bovine)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0046983
GN014302	GN014302.1	Q9Y3A2	51.0	206	254	253	2.10e-58	189	UTP11_HUMAN	Probable U3 small nucleolar RNA-associated protein 11 (U3 snoRNA-associated protein 11) (UTP11-like protein)	Homo sapiens (Human)	maturation of SSU-rRNA [GO:0030490]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; ribosomal small subunit biogenesis [GO:0042274]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	GO:0003723; GO:0005576; GO:0005654; GO:0005730; GO:0005737; GO:0007399; GO:0030490; GO:0032040; GO:0042274; GO:0043065
GN014303	GN014303.1	Q5RJ80	30.6	108	120	914	5.33e-11	61.6	CAPR2_DANRE	Caprin-2 (RNA granule protein 140)	Danio rerio (Zebrafish) (Brachydanio rerio)	dorsal/ventral axis specification [GO:0009950]; dorsal/ventral pattern formation [GO:0009953]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]	signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005102; GO:0005737; GO:0005886; GO:0009950; GO:0009953; GO:0030177; GO:0050775; GO:0061003; GO:0090263
GN014305	GN014305.1	Q5RJ80	31.5	108	120	914	8.27e-12	63.9	CAPR2_DANRE	Caprin-2 (RNA granule protein 140)	Danio rerio (Zebrafish) (Brachydanio rerio)	dorsal/ventral axis specification [GO:0009950]; dorsal/ventral pattern formation [GO:0009953]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]	signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005102; GO:0005737; GO:0005886; GO:0009950; GO:0009953; GO:0030177; GO:0050775; GO:0061003; GO:0090263
GN014312	GN014312.1	Q9VCA2	54.5	101	112	548	1.44e-27	108	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN014314	GN014314.1	Q0VC80	51.5	198	220	276	5.88e-65	205	YRDC_BOVIN	Threonylcarbamoyl-AMP synthase (EC 2.7.7.87)	Bos taurus (Bovine)	regulation of translational fidelity [GO:0006450]; tRNA threonylcarbamoyladenosine modification [GO:0002949]	double-stranded RNA binding [GO:0003725]; L-threonylcarbamoyladenylate synthase activity [GO:0061710]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0000049; GO:0002949; GO:0003725; GO:0005737; GO:0005739; GO:0005886; GO:0006450; GO:0016779; GO:0061710
GN014315	GN014315.1	Q8BTW8	59.1	530	625	588	4.83e-211	604	CK5P1_MOUSE	Mitochondrial tRNA methylthiotransferase CDK5RAP1 (EC 2.8.4.3) (CDK5 activator-binding protein C42) (CDK5 regulatory subunit-associated protein 1) (mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase) (mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase)	Mus musculus (Mouse)	mitochondrial tRNA modification [GO:0070900]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of translational fidelity [GO:0045903]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; RNA modification [GO:0009451]	4 iron, 4 sulfur cluster binding [GO:0051539]; protein-containing complex binding [GO:0044877]; tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity [GO:0035597]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0000079; GO:0005654; GO:0005739; GO:0005759; GO:0005829; GO:0009451; GO:0035597; GO:0044877; GO:0045736; GO:0045737; GO:0045903; GO:0051539; GO:0070131; GO:0070900
GN014316	GN014316.1	Q9CY64	27.5	251	265	295	3.39e-22	96.3	BIEA_MOUSE	Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase)	Mus musculus (Mouse)	apoptotic DNA fragmentation [GO:0006309]; canonical NF-kappaB signal transduction [GO:0007249]; chemotaxis [GO:0006935]; complement component C5a signaling pathway [GO:0038178]; ear development [GO:0043583]; fatty acid metabolic process [GO:0006631]; gallbladder development [GO:0061010]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; glycogen metabolic process [GO:0005977]; heme catabolic process [GO:0042167]; hemoglobin metabolic process [GO:0020027]; homeostasis of number of cells [GO:0048872]; immune response [GO:0006955]; inflammatory response [GO:0006954]; insulin metabolic process [GO:1901142]; insulin receptor signaling pathway [GO:0008286]; lipid metabolic process [GO:0006629]; lipid oxidation [GO:0034440]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; pigment metabolic process [GO:0042440]; protein oxidation [GO:0018158]; protein phosphorylation [GO:0006468]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of catalytic activity [GO:0050790]; response to cyclosporin A [GO:1905237]; response to food [GO:0032094]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979]; sensory perception of itch [GO:0160025]; triglyceride metabolic process [GO:0006641]	biliberdin reductase (NADH) activity [GO:0106276]; biliverdin reductase (NADPH) activity [GO:0106277]; biliverdin reductase [NAD(P)H] activity [GO:0004074]; nucleotide binding [GO:0000166]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000165; GO:0000166; GO:0000978; GO:0004074; GO:0004674; GO:0005634; GO:0005737; GO:0005829; GO:0005977; GO:0006309; GO:0006468; GO:0006629; GO:0006631; GO:0006641; GO:0006935; GO:0006954; GO:0006955; GO:0006979; GO:0007249; GO:0008270; GO:0008286; GO:0009986; GO:0010467; GO:0018105; GO:0018158; GO:0020027; GO:0032094; GO:0032496; GO:0034440; GO:0038178; GO:0042167; GO:0042440; GO:0042593; GO:0043066; GO:0043491; GO:0043583; GO:0048872; GO:0050790; GO:0061010; GO:0106276; GO:0106277; GO:0160025; GO:1901142; GO:1903409; GO:1905237
GN014317	GN014317.1	Q7TN88	30.2	1194	3906	2461	2.53e-145	513	PK1L2_MOUSE	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Mus musculus (Mouse)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]	membrane [GO:0016020]	GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN014318	GN014318.1	P56950	26.2	557	613	487	1.43e-32	134	MDM2_CANLF	E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Cdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)	Canis lupus familiaris (Dog) (Canis familiaris)	apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of mitotic cell cycle [GO:0045931]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; ubiquitin-dependent protein catabolic process [GO:0006511]	5S rRNA binding [GO:0008097]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; ribonucleoprotein complex binding [GO:0043021]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0002039; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006511; GO:0006915; GO:0008097; GO:0010468; GO:0016567; GO:0042802; GO:0043021; GO:0043066; GO:0043130; GO:0045931; GO:0061630
GN014319	GN014319.1	O77783	59.4	529	524	718	5.06e-231	656	EXT2_BOVIN	Exostosin-2 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (HS-polymerase) (HS-POL)	Bos taurus (Bovine)	heparan sulfate proteoglycan biosynthetic process [GO:0015012]	acetylglucosaminyltransferase activity [GO:0008375]; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020]; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509]	catalytic complex [GO:1902494]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0005576; GO:0005783; GO:0005789; GO:0005794; GO:0008375; GO:0015012; GO:0015020; GO:0016020; GO:0050508; GO:0050509; GO:1902494
GN014321	GN014321.1	Q9VEG6	36.7	548	834	809	1.14e-93	315	PERC_DROME	Chorion peroxidase (EC 1.11.1.7) (Peroxinectin-related protein) (Dpxt)	Drosophila melanogaster (Fruit fly)	chorion-containing eggshell formation [GO:0007304]; egg chorion assembly [GO:0007306]; follicle cell of egg chamber development [GO:0030707]; hydrogen peroxide metabolic process [GO:0042743]; prostaglandin biosynthetic process [GO:0001516]; response to oxidative stress [GO:0006979]	heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; peroxidase activity [GO:0004601]	extracellular region [GO:0005576]	GO:0001516; GO:0004601; GO:0005576; GO:0006979; GO:0007304; GO:0007306; GO:0020037; GO:0030707; GO:0042743; GO:0140825
GN014322	GN014322.1	P97865	48.1	312	321	318	4.94e-71	226	PEX7_MOUSE	Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7)	Mus musculus (Mouse)	endochondral ossification [GO:0001958]; ether lipid biosynthetic process [GO:0008611]; fatty acid beta-oxidation [GO:0006635]; neuron migration [GO:0001764]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein targeting to peroxisome [GO:0006625]	enzyme binding [GO:0019899]; peroxisome matrix targeting signal-2 binding [GO:0005053]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0001764; GO:0001958; GO:0005053; GO:0005777; GO:0005782; GO:0005829; GO:0006625; GO:0006635; GO:0007031; GO:0008611; GO:0016558; GO:0019899; GO:0042803
GN014324	GN014324.1	Q5B778	30.3	370	356	675	1.98e-36	142	CCR4_EMENI	CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4 (EC 3.1.13.4) (Carbon catabolite repressor protein 4) (Cytoplasmic deadenylase) (Glucose-repressible alcohol dehydrogenase transcriptional effector)	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)	DNA replication [GO:0006260]; DNA replication checkpoint signaling [GO:0000076]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; transcription elongation by RNA polymerase II [GO:0006368]; traversing start control point of mitotic cell cycle [GO:0007089]	3'-5'-RNA exonuclease activity [GO:0000175]; poly(A)-specific ribonuclease activity [GO:0004535]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; Cdc73/Paf1 complex [GO:0016593]; nucleus [GO:0005634]; P-body [GO:0000932]	GO:0000076; GO:0000175; GO:0000289; GO:0000932; GO:0004535; GO:0005634; GO:0006260; GO:0006368; GO:0007089; GO:0016593; GO:0030014; GO:0030015; GO:0032968
GN014325	GN014325.1	Q8TCB7	63.6	261	337	284	2.13e-115	338	METL6_HUMAN	tRNA N(3)-cytidine methyltransferase METTL6 (EC 2.1.1.-) (Methyltransferase-like protein 6) (hMETTL6)	Homo sapiens (Human)	tRNA C3-cytosine methylation [GO:0106217]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]	enzyme binding [GO:0019899]; tRNA (cytidine-N3)-methyltransferase activity [GO:0052735]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; tRNA methyltransferase complex [GO:0043527]	GO:0005634; GO:0005737; GO:0006400; GO:0019899; GO:0030488; GO:0043527; GO:0052735; GO:0106217
GN014326	GN014326.1	Q86QH9	77.8	81	265	202	1.05e-28	111	H1L1_OSTED	Sperm-specific H1/protamine-like protein type 1 [Cleaved into: Sperm-specific protein OE1 (Sperm-specific linker histone H1-like protein OE1); Sperm-specific protein OE3 (Protamine-like OS3)]	Ostrea edulis (Native oyster) (European flat oyster)	nucleosome assembly [GO:0006334]	DNA binding [GO:0003677]	nucleosome [GO:0000786]; nucleus [GO:0005634]	GO:0000786; GO:0003677; GO:0005634; GO:0006334
GN014327	GN014327.1	A3KG59	49.2	124	138	431	2.52e-28	110	P20D2_MOUSE	Xaa-Arg dipeptidase (EC 3.4.13.4)	Mus musculus (Mouse)	proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246]	dipeptidase activity [GO:0016805]; identical protein binding [GO:0042802]	nucleoplasm [GO:0005654]	GO:0005654; GO:0006508; GO:0016805; GO:0042802; GO:0051246
GN014328	GN014328.1	A3KG59	47.5	183	186	431	1.53e-53	179	P20D2_MOUSE	Xaa-Arg dipeptidase (EC 3.4.13.4)	Mus musculus (Mouse)	proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246]	dipeptidase activity [GO:0016805]; identical protein binding [GO:0042802]	nucleoplasm [GO:0005654]	GO:0005654; GO:0006508; GO:0016805; GO:0042802; GO:0051246
GN014330	GN014330.1	Q925Q9	28.3	421	392	709	1.97e-23	105	SH3K1_RAT	SH3 domain-containing kinase-binding protein 1 (Regulator of ubiquitous kinase) (Ruk) (SH3-containing, expressed in tumorigenic astrocytes)	Rattus norvegicus (Rat)	actin filament organization [GO:0007015]; cell migration [GO:0016477]; positive regulation of B cell activation [GO:0050871]; regulation of apoptotic process [GO:0042981]	protein-macromolecule adaptor activity [GO:0030674]; ubiquitin protein ligase binding [GO:0031625]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	GO:0005737; GO:0005829; GO:0005856; GO:0005911; GO:0005925; GO:0007015; GO:0014069; GO:0016477; GO:0030139; GO:0030659; GO:0030674; GO:0031625; GO:0042981; GO:0045202; GO:0050871; GO:0098978; GO:0098982
GN014331	GN014331.1	Q0U7W4	27.2	383	970	597	9.51e-27	120	CCR4_PHANO	CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4 (EC 3.1.13.4) (Carbon catabolite repressor protein 4) (Cytoplasmic deadenylase) (Glucose-repressible alcohol dehydrogenase transcriptional effector)	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)	nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]	3'-5'-RNA exonuclease activity [GO:0000175]; poly(A)-specific ribonuclease activity [GO:0004535]	CCR4-NOT complex [GO:0030014]; CCR4-NOT core complex [GO:0030015]; nucleus [GO:0005634]; P-body [GO:0000932]	GO:0000175; GO:0000289; GO:0000932; GO:0004535; GO:0005634; GO:0030014; GO:0030015
GN014338	GN014338.1	Q2Q0I9	43.0	128	486	1779	4.37e-22	103	FNDC1_RAT	Fibronectin type III domain-containing protein 1 (Activator of G protein signaling 8)	Rattus norvegicus (Rat)	cellular response to hypoxia [GO:0071456]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of protein phosphorylation [GO:0001934]; regulation of protein transport [GO:0051223]		cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	GO:0001934; GO:0005576; GO:0005737; GO:0005886; GO:0005911; GO:0010666; GO:0031966; GO:0051223; GO:0071456
GN014342	GN014342.1	Q9ER71	30.1	196	267	214	5.28e-14	72.4	RHOJ_MOUSE	Rho-related GTP-binding protein RhoJ (EC 3.6.5.2) (Tc10-like GTP-binding protein)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; regulation of cell shape [GO:0008360]; regulation of endothelial cell migration [GO:0010594]; regulation of sprouting angiogenesis [GO:1903670]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; Rho protein signal transduction [GO:0007266]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]	plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005525; GO:0005886; GO:0006897; GO:0007015; GO:0007266; GO:0008360; GO:0010594; GO:0019901; GO:0030010; GO:0030036; GO:0061299; GO:0090050; GO:1903670
GN014343	GN014343.1	P04634	52.9	293	337	395	5.81e-122	359	LIPF_RAT	Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3) (Lingual lipase)	Rattus norvegicus (Rat)	lipid metabolic process [GO:0006629]; malate metabolic process [GO:0006108]	lipase activity [GO:0016298]; malate dehydrogenase activity [GO:0016615]; triacylglycerol lipase activity [GO:0004806]	extracellular region [GO:0005576]; mitochondrion [GO:0005739]	GO:0004806; GO:0005576; GO:0005739; GO:0006108; GO:0006629; GO:0016298; GO:0016615
GN014344	GN014344.1	Q4R918	45.4	593	600	586	4.12e-149	445	KIF25_MACFA	Kinesin-like protein KIF25	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	establishment of spindle orientation [GO:0051294]; microtubule-based movement [GO:0007018]; negative regulation of mitotic centrosome separation [GO:0046603]; nucleus localization [GO:0051647]; protein homotetramerization [GO:0051289]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; minus-end-directed microtubule motor activity [GO:0008569]	centrosome [GO:0005813]	GO:0005524; GO:0005813; GO:0007018; GO:0008017; GO:0008569; GO:0046603; GO:0051289; GO:0051294; GO:0051647
GN014345	GN014345.1	Q3UDE2	48.9	532	559	639	7.11e-172	504	TTL12_MOUSE	Tubulin--tyrosine ligase-like protein 12 (Inactive tubulin--tyrosine ligase-like protein 12)	Mus musculus (Mouse)	negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; regulation of mitotic cell cycle [GO:0007346]	acid-amino acid ligase activity [GO:0016881]; catalytic activity, acting on a protein [GO:0140096]; histone H4K20me2 reader activity [GO:0140005]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]	GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0005886; GO:0007346; GO:0016881; GO:0030496; GO:0060339; GO:0140005; GO:0140096
GN014346	GN014346.1	Q3UDE2	57.8	90	163	639	6.08e-30	117	TTL12_MOUSE	Tubulin--tyrosine ligase-like protein 12 (Inactive tubulin--tyrosine ligase-like protein 12)	Mus musculus (Mouse)	negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; regulation of mitotic cell cycle [GO:0007346]	acid-amino acid ligase activity [GO:0016881]; catalytic activity, acting on a protein [GO:0140096]; histone H4K20me2 reader activity [GO:0140005]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle [GO:0005819]	GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0005886; GO:0007346; GO:0016881; GO:0030496; GO:0060339; GO:0140005; GO:0140096
GN014347	GN014347.1	Q61184	23.1	281	351	353	5.57e-19	90.1	MTR1A_MOUSE	Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)	Mus musculus (Mouse)	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; circadian rhythm [GO:0007623]; negative regulation of insulin secretion [GO:0046676]	G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; melatonin receptor activity [GO:0008502]	neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004930; GO:0005886; GO:0007193; GO:0007623; GO:0008502; GO:0042562; GO:0043025; GO:0043235; GO:0046676
GN014348	GN014348.1	Q9Y5L0	55.1	810	810	923	0.0	934	TNPO3_HUMAN	Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)	Homo sapiens (Human)	protein import into nucleus [GO:0006606]	identical protein binding [GO:0042802]; nuclear import signal receptor activity [GO:0061608]; small GTPase binding [GO:0031267]	annulate lamellae [GO:0005642]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]	GO:0005635; GO:0005642; GO:0005654; GO:0005737; GO:0005829; GO:0006606; GO:0031267; GO:0042802; GO:0061608
GN014349	GN014349.1	Q80X66	69.2	295	442	475	2.44e-145	426	BTBDA_MOUSE	BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1)	Mus musculus (Mouse)	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]		cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001650; GO:0005634; GO:0005654; GO:0005737; GO:0051897
GN014351	GN014351.1	Q6DGR4	46.3	339	369	377	8.96e-94	288	HGH1_DANRE	Co-chaperone protein HGH1 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]	GO:0005737
GN014352	GN014352.1	Q9Z336	85.0	113	113	113	7.40e-69	204	DYLT1_RAT	Dynein light chain Tctex-type 1 (Activator of G protein signaling 2) (AGS2) (T-complex testis-specific protein 1 homolog)	Rattus norvegicus (Rat)	axon development [GO:0061564]; cardiac muscle cell apoptotic process [GO:0010659]; dendrite development [GO:0016358]; establishment of mitotic spindle orientation [GO:0000132]; intracellular protein transport [GO:0006886]; intracellular transport of viral protein in host cell [GO:0019060]; microtubule-based movement [GO:0007018]; negative regulation of mitochondrial membrane permeability [GO:0035795]; negative regulation of neurogenesis [GO:0050768]; neuron projection morphogenesis [GO:0048812]; positive regulation of neuron projection development [GO:0010976]; positive regulation of Rac protein signal transduction [GO:0035022]; regulation of cytoskeleton organization [GO:0051493]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of GTPase activity [GO:0043087]	dynein intermediate chain binding [GO:0045505]; identical protein binding [GO:0042802]; transmembrane transporter binding [GO:0044325]	axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytoplasmic microtubule [GO:0005881]; Golgi apparatus [GO:0005794]; host cell [GO:0043657]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; photoreceptor inner segment [GO:0001917]; secretory vesicle [GO:0099503]; spindle [GO:0005819]	GO:0000132; GO:0001917; GO:0005737; GO:0005794; GO:0005819; GO:0005868; GO:0005881; GO:0006886; GO:0007018; GO:0008277; GO:0010659; GO:0010976; GO:0016358; GO:0019060; GO:0030027; GO:0035022; GO:0035795; GO:0042802; GO:0043025; GO:0043087; GO:0043657; GO:0044295; GO:0044325; GO:0045505; GO:0048812; GO:0050768; GO:0051493; GO:0061564; GO:0099503
GN014355	GN014355.1	Q3T174	66.4	119	168	161	2.67e-49	159	TAF12_BOVIN	Transcription initiation factor TFIID subunit 12 (Transcription initiation factor TFIID 20/15 kDa subunits) (TAFII-20/TAFII-15) (TAFII20/TAFII15)	Bos taurus (Bovine)	RNA polymerase II preinitiation complex assembly [GO:0051123]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; TBP-class protein binding [GO:0017025]	SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]	GO:0000124; GO:0003677; GO:0005669; GO:0017025; GO:0046982; GO:0051123
GN014356	GN014356.1	Q95K40	31.7	382	428	413	5.37e-42	156	CCD83_MACFA	Coiled-coil domain-containing protein 83	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)				
GN014358	GN014358.1	Q7TQE7	32.9	343	555	519	2.20e-43	165	MACA2_MOUSE	Putative tyrosine carboxypeptidase MATCAP2 (EC 3.4.17.-)	Mus musculus (Mouse)				
GN014359	GN014359.1	Q9NZJ6	50.9	218	224	369	1.16e-73	230	COQ3_HUMAN	Ubiquinone biosynthesis O-methyltransferase, mitochondrial (3-demethylubiquinol 3-O-methyltransferase) (EC 2.1.1.64) (3-demethylubiquinone 3-O-methyltransferase) (EC 2.1.1.-) (Polyprenyldihydroxybenzoate methyltransferase) (EC 2.1.1.114)	Homo sapiens (Human)	glycerol metabolic process [GO:0006071]; ubiquinone biosynthetic process [GO:0006744]	3-demethylubiquinol 3-O-methyltransferase activity [GO:0061542]; 3-demethylubiquinone 3-O-methyltransferase activity [GO:0120537]; O-methyltransferase activity [GO:0008171]; polyprenyldihydroxybenzoate methyltransferase activity [GO:0010420]	extrinsic component of mitochondrial inner membrane [GO:0031314]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ubiquinone biosynthesis complex [GO:0110142]	GO:0005739; GO:0005743; GO:0005759; GO:0006071; GO:0006744; GO:0008171; GO:0010420; GO:0031314; GO:0061542; GO:0110142; GO:0120537
GN014364	GN014364.1	V5NAL9	36.1	122	128	899	6.22e-22	93.2	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN014365	GN014365.1	Q9ES30	37.2	129	131	246	9.81e-15	71.2	C1QT3_MOUSE	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	Mus musculus (Mouse)	fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; intracellular triglyceride homeostasis [GO:0035356]; maintenance of synapse structure [GO:0099558]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular region [GO:0005576]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001819; GO:0005576; GO:0010629; GO:0032715; GO:0032991; GO:0035356; GO:0042593; GO:0042802; GO:0043083; GO:0045202; GO:0045444; GO:0045721; GO:0050728; GO:0051897; GO:0070165; GO:0070374; GO:0071638; GO:0099550; GO:0099558; GO:1901223
GN014368	GN014368.1	Q05A80	32.1	109	130	1031	1.39e-10	60.8	CAPR2_MOUSE	Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (RNA granule protein 140)	Mus musculus (Mouse)	negative regulation of cell growth [GO:0030308]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of transcription by RNA polymerase II [GO:0045944]	signaling receptor binding [GO:0005102]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0005102; GO:0005654; GO:0005737; GO:0005739; GO:0005813; GO:0005829; GO:0005886; GO:0030308; GO:0043235; GO:0045944; GO:0050775; GO:0061003; GO:0090263
GN014373	GN014373.1	A3KG59	49.6	125	123	431	5.25e-26	103	P20D2_MOUSE	Xaa-Arg dipeptidase (EC 3.4.13.4)	Mus musculus (Mouse)	proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246]	dipeptidase activity [GO:0016805]; identical protein binding [GO:0042802]	nucleoplasm [GO:0005654]	GO:0005654; GO:0006508; GO:0016805; GO:0042802; GO:0051246
GN014374	GN014374.1	A3KG59	72.1	61	61	431	1.63e-25	99.4	P20D2_MOUSE	Xaa-Arg dipeptidase (EC 3.4.13.4)	Mus musculus (Mouse)	proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246]	dipeptidase activity [GO:0016805]; identical protein binding [GO:0042802]	nucleoplasm [GO:0005654]	GO:0005654; GO:0006508; GO:0016805; GO:0042802; GO:0051246
GN014375	GN014375.1	Q501L1	66.2	68	77	443	8.26e-23	92.8	P20D2_XENTR	Peptidase M20 domain-containing protein 2 (Aminoacylase-1-like protein 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		dipeptidase activity [GO:0016805]		GO:0016805
GN014376	GN014376.1	A3KG59	52.4	397	396	431	3.10e-128	379	P20D2_MOUSE	Xaa-Arg dipeptidase (EC 3.4.13.4)	Mus musculus (Mouse)	proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246]	dipeptidase activity [GO:0016805]; identical protein binding [GO:0042802]	nucleoplasm [GO:0005654]	GO:0005654; GO:0006508; GO:0016805; GO:0042802; GO:0051246
GN014377	GN014377.1	Q501L1	48.8	166	175	443	3.01e-41	146	P20D2_XENTR	Peptidase M20 domain-containing protein 2 (Aminoacylase-1-like protein 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		dipeptidase activity [GO:0016805]		GO:0016805
GN014378	GN014378.1	A3KG59	53.6	179	185	431	1.07e-60	197	P20D2_MOUSE	Xaa-Arg dipeptidase (EC 3.4.13.4)	Mus musculus (Mouse)	proteolysis [GO:0006508]; regulation of protein metabolic process [GO:0051246]	dipeptidase activity [GO:0016805]; identical protein binding [GO:0042802]	nucleoplasm [GO:0005654]	GO:0005654; GO:0006508; GO:0016805; GO:0042802; GO:0051246
GN014379	GN014379.1	Q16526	75.4	500	562	586	6.00e-297	820	CRY1_HUMAN	Cryptochrome-1	Homo sapiens (Human)	blue light signaling pathway [GO:0009785]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; lipid storage [GO:0019915]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of glucocorticoid secretion [GO:2000850]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway [GO:2000323]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of protein ubiquitination [GO:0031398]; regulation of circadian rhythm [GO:0042752]; regulation of DNA damage checkpoint [GO:2000001]; response to activity [GO:0014823]; response to glucagon [GO:0033762]; response to insulin [GO:0032868]; response to light stimulus [GO:0009416]; signal transduction in response to DNA damage [GO:0042770]	blue light photoreceptor activity [GO:0009882]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; E-box binding [GO:0070888]; histone deacetylase binding [GO:0042826]; nuclear receptor binding [GO:0016922]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0003677; GO:0003690; GO:0005634; GO:0005654; GO:0005739; GO:0006094; GO:0007623; GO:0009416; GO:0009785; GO:0009882; GO:0014823; GO:0016922; GO:0019901; GO:0019902; GO:0019915; GO:0031397; GO:0031398; GO:0032868; GO:0032922; GO:0033762; GO:0042593; GO:0042752; GO:0042754; GO:0042770; GO:0042826; GO:0043153; GO:0045721; GO:0045722; GO:0045744; GO:0045892; GO:0070888; GO:2000001; GO:2000323; GO:2000850
GN014381	GN014381.1	Q12996	64.9	222	306	717	1.09e-90	287	CSTF3_HUMAN	Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77)	Homo sapiens (Human)	co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]; regulation of mRNA 3'-end processing [GO:0031440]	RNA binding [GO:0003723]	mRNA cleavage stimulating factor complex [GO:0005848]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005654; GO:0005848; GO:0031440; GO:0180010
GN014382	GN014382.1	Q148M7	72.4	98	121	124	9.40e-49	154	TAF13_BOVIN	Transcription initiation factor TFIID subunit 13 (Transcription initiation factor TFIID 18 kDa subunit) (TAF(II)18) (TAFII-18) (TAFII18)	Bos taurus (Bovine)	transcription by RNA polymerase II [GO:0006366]	protein heterodimerization activity [GO:0046982]	nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]	GO:0005634; GO:0005669; GO:0006366; GO:0046982
GN014387	GN014387.1	Q9ES30	32.8	128	137	246	2.26e-11	62.4	C1QT3_MOUSE	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	Mus musculus (Mouse)	fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; intracellular triglyceride homeostasis [GO:0035356]; maintenance of synapse structure [GO:0099558]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular region [GO:0005576]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001819; GO:0005576; GO:0010629; GO:0032715; GO:0032991; GO:0035356; GO:0042593; GO:0042802; GO:0043083; GO:0045202; GO:0045444; GO:0045721; GO:0050728; GO:0051897; GO:0070165; GO:0070374; GO:0071638; GO:0099550; GO:0099558; GO:1901223
GN014390	GN014390.1	Q7Z5L3	32.7	110	119	287	6.06e-10	58.2	C1QL2_HUMAN	Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; regulation of synapse maturation [GO:0090128]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0032991; GO:0042802; GO:0043083; GO:0045202; GO:0090128; GO:0097107; GO:0098686; GO:0099550; GO:0099558; GO:0099645; GO:0150053
GN014391	GN014391.1	Q9BXJ4	33.1	127	127	246	3.14e-10	58.9	C1QT3_HUMAN	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	Homo sapiens (Human)	fat cell differentiation [GO:0045444]; intracellular triglyceride homeostasis [GO:0035356]; maintenance of synapse structure [GO:0099558]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001819; GO:0010629; GO:0016020; GO:0032715; GO:0032991; GO:0035356; GO:0042802; GO:0043083; GO:0045202; GO:0045444; GO:0045721; GO:0050728; GO:0070062; GO:0070165; GO:0071638; GO:0099550; GO:0099558; GO:1901223
GN014392	GN014392.1	Q80Y75	62.9	318	317	316	3.16e-146	417	DJB13_MOUSE	DnaJ homolog subfamily B member 13 (Testis and spermatogenesis cell-related protein 6) (Testis spermatocyte apoptosis-related gene 6 protein) (Testis spermatogenesis apoptosis-related gene 3 protein) (Testis spermatogenesis apoptosis-related gene 6 protein)	Mus musculus (Mouse)	axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; flagellated sperm motility [GO:0030317]; mating [GO:0007618]; protein folding [GO:0006457]	protein-folding chaperone binding [GO:0051087]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; sperm end piece [GO:0097229]; sperm flagellum [GO:0036126]; sperm head-tail coupling apparatus [GO:0120212]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0001534; GO:0003341; GO:0003351; GO:0005576; GO:0005737; GO:0005829; GO:0005929; GO:0005930; GO:0006457; GO:0007618; GO:0030317; GO:0031514; GO:0036126; GO:0051087; GO:0097225; GO:0097228; GO:0097229; GO:0097729; GO:0120212; GO:1904158
GN014393	GN014393.1	Q6ZTR5	34.4	3273	3211	3187	0.0	1793	CFA47_HUMAN	Cilia- and flagella-associated protein 47	Homo sapiens (Human)	cilium assembly [GO:0060271]; sperm axoneme assembly [GO:0007288]		cilium [GO:0005929]; sperm head-tail coupling apparatus [GO:0120212]	GO:0005929; GO:0007288; GO:0060271; GO:0120212
GN014394	GN014394.1	Q14978	60.2	93	1103	699	1.62e-23	110	NOLC1_HUMAN	Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)	Homo sapiens (Human)	mitotic cell cycle [GO:0000278]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; regulation of translation [GO:0006417]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]	molecular function inhibitor activity [GO:0140678]; protein heterodimerization activity [GO:0046982]; protein kinase inhibitor activity [GO:0004860]; protein-macromolecule adaptor activity [GO:0030674]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0000278; GO:0001650; GO:0003723; GO:0004860; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0006417; GO:0014029; GO:0014032; GO:0030674; GO:0042254; GO:0046982; GO:0071901; GO:0140678
GN014396	GN014396.1	Q5SVZ6	30.6	445	635	1142	2.73e-49	189	ZMYM1_HUMAN	Zinc finger MYM-type protein 1	Homo sapiens (Human)		protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0005634; GO:0008270; GO:0046983
GN014398	GN014398.1	Q8NG08	31.5	930	1321	1087	2.43e-104	360	HELB_HUMAN	DNA helicase B (hDHB) (EC 5.6.2.3) (DNA 5'-3' helicase B)	Homo sapiens (Human)	DNA damage response [GO:0006974]; DNA replication [GO:0006260]; DNA replication, synthesis of primer [GO:0006269]; DNA-templated DNA replication [GO:0006261]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA double-strand break processing [GO:1903775]	5'-3' DNA helicase activity [GO:0043139]; ATP hydrolysis activity [GO:0016887]; protein-containing complex binding [GO:0044877]; single-stranded DNA helicase activity [GO:0017116]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005829; GO:0006260; GO:0006261; GO:0006269; GO:0006974; GO:0016604; GO:0016887; GO:0017116; GO:0035861; GO:0043139; GO:0044877; GO:1903775; GO:2000042
GN014400	GN014400.1	A0A1L8HCK2	63.8	290	290	290	8.22e-124	358	C298A_XENLA	Cilia- and flagella-associated protein 298-A (Protein kurly-A)	Xenopus laevis (African clawed frog)	regulation of cilium movement [GO:0003352]		cytoplasm [GO:0005737]	GO:0003352; GO:0005737
GN014401	GN014401.1	P58659	42.8	145	354	440	2.23e-35	137	EVA1C_MOUSE	Protein eva-1 homolog C (Protein FAM176C)	Mus musculus (Mouse)		carbohydrate binding [GO:0030246]; heparin binding [GO:0008201]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005576; GO:0005886; GO:0008201; GO:0030246
GN014404	GN014404.1	Q7T0B1	71.8	309	720	435	5.26e-146	436	STK40_CHICK	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine-protein kinase lyk4)	Gallus gallus (Chicken)	regulation of MAPK cascade [GO:0043408]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0043408; GO:0106310
GN014413	GN014413.1	P29240	43.7	565	576	577	9.87e-150	446	5NTD_DIPOM	5'-nucleotidase (EC 3.1.3.5) (Ecto-nucleotidase)	Diplobatis ommata (Ocellated electric ray) (Discopyge ommata)	AMP catabolic process [GO:0006196]	5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]	plasma membrane [GO:0005886]	GO:0000166; GO:0005886; GO:0006196; GO:0008253; GO:0046872
GN014414	GN014414.1	Q7Z5L3	33.8	139	211	287	3.36e-10	61.6	C1QL2_HUMAN	Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; regulation of synapse maturation [GO:0090128]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0032991; GO:0042802; GO:0043083; GO:0045202; GO:0090128; GO:0097107; GO:0098686; GO:0099550; GO:0099558; GO:0099645; GO:0150053
GN014422	GN014422.1	Q5T5N4	24.0	462	527	469	3.19e-14	78.6	CF118_HUMAN	Uncharacterized protein C6orf118	Homo sapiens (Human)				
GN014423	GN014423.1	P42577	80.1	171	171	174	1.07e-94	275	FRIS_LYMST	Soma ferritin (EC 1.16.3.1)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	intracellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]	ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]	cytoplasm [GO:0005737]	GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008198; GO:0008199
GN014426	GN014426.1	F4IUW3	25.3	415	440	550	1.84e-24	109	AVT1C_ARATH	Amino acid transporter AVT1C (AtAvt1C)	Arabidopsis thaliana (Mouse-ear cress)			nucleus [GO:0005634]; plant-type vacuole [GO:0000325]; plasma membrane [GO:0005886]	GO:0000325; GO:0005634; GO:0005886
GN014428	GN014428.1	P09108	32.6	396	395	412	2.62e-65	216	RAPSN_TETCF	43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein)	Tetronarce californica (Pacific electric ray) (Torpedo californica)	positive regulation of neuromuscular synaptic transmission [GO:1900075]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor binding [GO:0033130]; protein-membrane adaptor activity [GO:0043495]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; neuromuscular junction [GO:0031594]; postsynaptic membrane [GO:0045211]	GO:0005737; GO:0005856; GO:0007271; GO:0031594; GO:0033130; GO:0043495; GO:0045211; GO:1900075
GN014432	GN014432.1	O46560	54.5	319	315	322	5.31e-107	317	PDXK_PIG	Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase)	Sus scrofa (Pig)	pyridoxal 5'-phosphate salvage [GO:0009443]	pyridoxal kinase activity [GO:0008478]	cytosol [GO:0005829]	GO:0005829; GO:0008478; GO:0009443
GN014433	GN014433.1	Q9BUT1	66.7	246	246	245	9.38e-113	326	DHRS6_HUMAN	Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.-) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (EC 1.1.1.30) (4-oxo-L-proline reductase) (EC 1.1.1.104) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1)	Homo sapiens (Human)	epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; heme metabolic process [GO:0042168]; siderophore biosynthetic process [GO:0019290]	3-hydroxybutyrate dehydrogenase activity [GO:0003858]; 4-oxoproline reductase activity [GO:0016617]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0003858; GO:0005737; GO:0005829; GO:0006635; GO:0016617; GO:0016628; GO:0019290; GO:0030855; GO:0042168; GO:0051287; GO:0070062
GN014440	GN014440.1	A0A2B4RNI3	33.3	162	663	688	2.55e-21	102	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014442	GN014442.1	P91931	51.9	133	138	347	1.23e-38	136	DCAM_DROME	S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain]	Drosophila melanogaster (Fruit fly)	spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597]	adenosylmethionine decarboxylase activity [GO:0004014]	cytosol [GO:0005829]	GO:0004014; GO:0005829; GO:0006597; GO:0008295
GN014443	GN014443.1	P79888	56.5	131	175	335	2.19e-40	142	DCAM_XENLA	S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain]	Xenopus laevis (African clawed frog)	spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597]	adenosylmethionine decarboxylase activity [GO:0004014]	cytosol [GO:0005829]	GO:0004014; GO:0005829; GO:0006597; GO:0008295
GN014444	GN014444.1	Q3SWY8	43.7	380	758	579	1.78e-87	290	ZUP1_BOVIN	Zinc finger-containing ubiquitin peptidase 1 (EC 3.4.19.12) (Lys-63-specific deubiquitinase ZUFSP) (DUB) (Zinc finger with UFM1-specific peptidase domain protein)	Bos taurus (Bovine)	regulation of DNA-templated transcription [GO:0006355]	cysteine-type deubiquitinase activity [GO:0004843]; DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000976; GO:0003700; GO:0004843; GO:0005634; GO:0005737; GO:0006355
GN014445	GN014445.1	Q5ZI57	74.4	180	180	180	7.18e-99	286	TPPC3_CHICK	Trafficking protein particle complex subunit 3	Gallus gallus (Chicken)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]		cis-Golgi network membrane [GO:0033106]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; TRAPP complex [GO:0030008]	GO:0005783; GO:0005829; GO:0006888; GO:0006891; GO:0030008; GO:0033106
GN014447	GN014447.1	Q9V477	39.7	650	1144	1346	7.87e-64	241	TOLL8_DROME	Toll-like receptor Tollo (Toll-like receptor 8)	Drosophila melanogaster (Fruit fly)	axis elongation [GO:0003401]; convergent extension [GO:0060026]; peripheral nervous system neuron development [GO:0048935]; regulation of glycoprotein biosynthetic process [GO:0010559]; signal transduction [GO:0007165]	receptor ligand activity [GO:0048018]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0003401; GO:0005886; GO:0007165; GO:0010559; GO:0016324; GO:0048018; GO:0048935; GO:0060026
GN014448	GN014448.1	Q9UTA8	35.8	201	245	256	1.08e-29	114	YL8A_SCHPO	Uncharacterized methyltransferase-like C25B8.10 (EC 2.1.1.-)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	cellular detoxification [GO:1990748]	methyltransferase activity [GO:0008168]; trans-aconitate 3-methyltransferase activity [GO:0046547]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0008168; GO:0046547; GO:1990748
GN014449	GN014449.1	A0A2B4RNI3	31.7	183	620	688	2.01e-20	99.4	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014450	GN014450.1	P29145	44.1	571	779	710	1.21e-145	447	NECB_HYDVU	PC3-like endoprotease variant B (EC 3.4.21.-) (SPC3)	Hydra vulgaris (Hydra) (Hydra attenuata)	protein processing [GO:0016485]	serine-type endopeptidase activity [GO:0004252]	Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0004252; GO:0005802; GO:0016485
GN014451	GN014451.1	Q9U3S9	37.5	192	539	344	5.68e-37	143	NAS6_CAEEL	Zinc metalloproteinase nas-6 (EC 3.4.24.-) (Nematode astacin 6)	Caenorhabditis elegans	nematode pharyngeal pumping [GO:0043050]; nematode pharynx development [GO:0160094]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0004222; GO:0005576; GO:0006508; GO:0008270; GO:0043050; GO:0160094
GN014454	GN014454.1	P0DUE1	31.4	137	487	415	2.68e-10	65.9	STING_MAGGI	Stimulator of interferon genes protein (TIR-STING) (Probable NAD(+) hydrolase) (EC 3.2.2.6)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	activation of innate immune response [GO:0002218]; autophagosome assembly [GO:0000045]; innate immune response [GO:0045087]; positive regulation of macroautophagy [GO:0016239]; positive regulation of type I interferon production [GO:0032481]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; NAD+ nucleosidase activity, cyclic ADP-ribose generating [GO:0061809]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]	GO:0000045; GO:0002218; GO:0005776; GO:0005789; GO:0007165; GO:0016239; GO:0032481; GO:0035438; GO:0045087; GO:0061507; GO:0061709; GO:0061809
GN014458	GN014458.1	Q15418	72.8	588	599	735	1.97e-313	869	KS6A1_HUMAN	Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)	Homo sapiens (Human)	chemical synaptic transmission [GO:0007268]; hepatocyte proliferation [GO:0072574]; negative regulation of apoptotic process [GO:0043066]; negative regulation of TOR signaling [GO:0032007]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; regulation of translation in response to stress [GO:0043555]; signal transduction [GO:0007165]; TORC1 signaling [GO:0038202]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; mitogen-activated protein kinase binding [GO:0051019]; PDZ domain binding [GO:0030165]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ribosomal protein S6 kinase activity [GO:0004711]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; synapse [GO:0045202]	GO:0000287; GO:0004674; GO:0004711; GO:0004712; GO:0005524; GO:0005654; GO:0005829; GO:0006355; GO:0006468; GO:0007165; GO:0007268; GO:0030165; GO:0030307; GO:0032007; GO:0038202; GO:0043066; GO:0043555; GO:0045202; GO:0045597; GO:0045893; GO:0045944; GO:0051019; GO:0072574; GO:0106310; GO:2000491
GN014461	GN014461.1	Q0VA82	23.1	484	464	504	8.42e-17	86.3	MFSD8_DANRE	Major facilitator superfamily domain-containing protein 8	Danio rerio (Zebrafish) (Brachydanio rerio)	autophagosome maturation [GO:0097352]; lysosome organization [GO:0007040]	chloride channel activity [GO:0005254]; iodide transmembrane transporter activity [GO:0015111]	lysosomal membrane [GO:0005765]	GO:0005254; GO:0005765; GO:0007040; GO:0015111; GO:0097352
GN014463	GN014463.1	A7S2N8	46.9	759	779	790	4.50e-222	646	UFL1_NEMVE	E3 UFM1-protein ligase 1 homolog (EC 2.3.2.-) (E3 UFM1-protein transferase 1 homolog)	Nematostella vectensis (Starlet sea anemone)	protein ufmylation [GO:0071569]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]	UFM1 ligase activity [GO:0061666]; UFM1 transferase activity [GO:0071568]	endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0034976; GO:0061666; GO:0061709; GO:0071568; GO:0071569
GN014464	GN014464.1	A1A4I9	60.4	53	69	792	1.11e-14	69.7	UFL1_BOVIN	E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1)	Bos taurus (Bovine)	DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; erythrocyte differentiation [GO:0030218]; hematopoietic stem cell differentiation [GO:0060218]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell mediated immune response to tumor cell [GO:0002841]; positive regulation of autophagy [GO:0010508]; positive regulation of reticulophagy [GO:0140501]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of inflammatory response [GO:0050727]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; rescue of stalled cytosolic ribosome [GO:0072344]; response to endoplasmic reticulum stress [GO:0034976]; reticulophagy [GO:0061709]; ribosome disassembly [GO:0032790]	UFM1 ligase activity [GO:0061666]; UFM1 transferase activity [GO:0071568]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000077; GO:0002841; GO:0005634; GO:0005694; GO:0005737; GO:0005783; GO:0005789; GO:0005829; GO:0006974; GO:0010508; GO:0030218; GO:0031397; GO:0032790; GO:0033146; GO:0034976; GO:0035861; GO:0043122; GO:0050727; GO:0050868; GO:0060218; GO:0061666; GO:0061709; GO:0071568; GO:0071569; GO:0072344; GO:0140501; GO:1903895; GO:1990592
GN014468	GN014468.1	P70496	36.1	1323	1378	1074	2.83e-248	744	PLD1_RAT	Phospholipase D1 (PLD 1) (rPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1)	Rattus norvegicus (Rat)	cellular response to nutrient [GO:0031670]; defense response to Gram-positive bacterium [GO:0050830]; intracellular signal transduction [GO:0035556]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]; phospholipid catabolic process [GO:0009395]; positive regulation of cell migration [GO:0030335]; positive regulation of translation [GO:0045727]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of vesicle-mediated transport [GO:0060627]; response to peptide hormone [GO:0043434]	D-type glycerophospholipase activity [GO:0004630]; phosphatidylinositol binding [GO:0035091]	apical plasma membrane [GO:0016324]; cholinergic synapse [GO:0098981]; cytoplasmic vesicle [GO:0031410]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; vesicle [GO:0031982]	GO:0000139; GO:0004630; GO:0005764; GO:0005768; GO:0005789; GO:0005794; GO:0005886; GO:0006654; GO:0008654; GO:0009395; GO:0016324; GO:0030027; GO:0030139; GO:0030335; GO:0031410; GO:0031670; GO:0031902; GO:0031982; GO:0031985; GO:0035091; GO:0035556; GO:0043434; GO:0045202; GO:0045727; GO:0048471; GO:0050830; GO:0060627; GO:0098693; GO:0098981
GN014469	GN014469.1	Q9NYP3	43.7	183	332	566	1.88e-37	144	DONS_HUMAN	Protein downstream neighbor of Son (B17)	Homo sapiens (Human)	DNA damage checkpoint signaling [GO:0000077]; DNA replication [GO:0006260]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; nuclear DNA replication [GO:0033260]; replication fork processing [GO:0031297]		nucleus [GO:0005634]; replication fork [GO:0005657]; replisome [GO:0030894]	GO:0000077; GO:0005634; GO:0005657; GO:0006260; GO:0007095; GO:0030894; GO:0031297; GO:0033260; GO:0033314
GN014470	GN014470.1	Q9CPU4	48.5	130	142	153	4.36e-37	127	MGST3_MOUSE	Glutathione S-transferase 3, mitochondrial (EC 2.5.1.-) (Glutathione peroxidase MGST3) (EC 1.11.1.-) (LTC4 synthase MGST3) (EC 4.4.1.20)	Mus musculus (Mouse)	arachidonate metabolic process [GO:0019369]; leukotriene biosynthetic process [GO:0019370]; lipid metabolic process [GO:0006629]; prostanoid metabolic process [GO:0006692]	glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]	GO:0004364; GO:0004464; GO:0004602; GO:0005635; GO:0005741; GO:0005783; GO:0006629; GO:0006692; GO:0016020; GO:0019369; GO:0019370; GO:0042802; GO:0047066
GN014471	GN014471.1	Q9CPU4	44.6	130	142	153	1.06e-32	115	MGST3_MOUSE	Glutathione S-transferase 3, mitochondrial (EC 2.5.1.-) (Glutathione peroxidase MGST3) (EC 1.11.1.-) (LTC4 synthase MGST3) (EC 4.4.1.20)	Mus musculus (Mouse)	arachidonate metabolic process [GO:0019369]; leukotriene biosynthetic process [GO:0019370]; lipid metabolic process [GO:0006629]; prostanoid metabolic process [GO:0006692]	glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; leukotriene-C4 synthase activity [GO:0004464]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nuclear envelope [GO:0005635]	GO:0004364; GO:0004464; GO:0004602; GO:0005635; GO:0005741; GO:0005783; GO:0006629; GO:0006692; GO:0016020; GO:0019369; GO:0019370; GO:0042802; GO:0047066
GN014475	GN014475.1	Q8AYK6	51.9	372	422	571	2.04e-115	352	WEE1A_XENLA	Wee1-like protein kinase 1-A (EC 2.7.10.2) (Zygotic wee1-like protein kinase 2) (XWee2)	Xenopus laevis (African clawed frog)	mitotic cell cycle [GO:0000278]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000278; GO:0000287; GO:0004713; GO:0004715; GO:0005524; GO:0005634; GO:0005737; GO:0010972
GN014479	GN014479.1	O35115	43.1	343	641	279	4.03e-106	325	FHL2_RAT	Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)	Rattus norvegicus (Rat)	atrial cardiac muscle cell development [GO:0055014]; heart trabecula formation [GO:0060347]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hormone [GO:0009725]; ventricular cardiac muscle cell development [GO:0055015]	bHLH transcription factor binding [GO:0043425]; identical protein binding [GO:0042802]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; M band [GO:0031430]; nucleus [GO:0005634]; Z disc [GO:0030018]	GO:0000122; GO:0001649; GO:0003714; GO:0005634; GO:0005737; GO:0005925; GO:0006357; GO:0008134; GO:0009725; GO:0015629; GO:0030018; GO:0031430; GO:0042802; GO:0043066; GO:0043425; GO:0055014; GO:0055015; GO:0060347; GO:0070885
GN014484	GN014484.1	Q9LIG0	47.2	326	336	330	7.93e-109	323	Y3136_ARATH	Clavaminate synthase-like protein At3g21360 (EC 1.-.-.-)	Arabidopsis thaliana (Mouse-ear cress)		oxidoreductase activity [GO:0016491]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0016491
GN014492	GN014492.1	Q8BV66	28.7	258	304	422	4.05e-18	87.4	IFI44_MOUSE	Interferon-induced protein 44 (Microtubule-associated protein 44)	Mus musculus (Mouse)	cellular response to virus [GO:0098586]; immune response [GO:0006955]; response to bacterium [GO:0009617]		cytoplasm [GO:0005737]	GO:0005737; GO:0006955; GO:0009617; GO:0098586
GN014494	GN014494.1	Q8BV66	27.3	260	304	422	8.72e-19	89.4	IFI44_MOUSE	Interferon-induced protein 44 (Microtubule-associated protein 44)	Mus musculus (Mouse)	cellular response to virus [GO:0098586]; immune response [GO:0006955]; response to bacterium [GO:0009617]		cytoplasm [GO:0005737]	GO:0005737; GO:0006955; GO:0009617; GO:0098586
GN014495	GN014495.1	P17276	65.9	408	461	452	3.59e-201	567	PH4H_DROME	Protein henna (EC 1.14.16.1) (EC 1.14.16.4) (Phe-4-monooxygenase) (Phenylalanine-4-hydroxylase) (PAH) (Tryptophan 5-hydroxylase) (TRH) (Tryptophan 5-monooxygenase)	Drosophila melanogaster (Fruit fly)	dopamine biosynthetic process [GO:0042416]; eye pigment biosynthetic process [GO:0006726]; germ-band extension [GO:0007377]; L-phenylalanine catabolic process [GO:0006559]; L-tyrosine biosynthetic process [GO:0006571]; long-term memory [GO:0007616]; serotonin biosynthetic process [GO:0042427]	iron ion binding [GO:0005506]; phenylalanine 4-monooxygenase activity [GO:0004505]; tryptophan 5-monooxygenase activity [GO:0004510]	cytosol [GO:0005829]	GO:0004505; GO:0004510; GO:0005506; GO:0005829; GO:0006559; GO:0006571; GO:0006726; GO:0007377; GO:0007616; GO:0042416; GO:0042427
GN014496	GN014496.1	Q9H628	40.1	212	220	204	3.23e-36	129	RERGL_HUMAN	Ras-related and estrogen-regulated growth inhibitor-like protein (EC 3.6.5.2) (RERG/Ras-like protein)	Homo sapiens (Human)		G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]		GO:0003924; GO:0003925; GO:0005525
GN014497	GN014497.1	Q16543	57.1	343	380	378	5.22e-125	368	CDC37_HUMAN	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]	Homo sapiens (Human)	positive regulation of type 2 mitophagy [GO:1905091]; post-transcriptional regulation of gene expression [GO:0010608]; protein folding [GO:0006457]; protein maturation [GO:0051604]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; regulation of type II interferon-mediated signaling pathway [GO:0060334]	heat shock protein binding [GO:0031072]; Hsp90 protein binding [GO:0051879]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; protein-folding chaperone binding [GO:0051087]; scaffold protein binding [GO:0097110]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; HSP90-CDC37 chaperone complex [GO:1990565]; protein folding chaperone complex [GO:0101031]	GO:0000079; GO:0005737; GO:0005829; GO:0006457; GO:0006605; GO:0010608; GO:0019887; GO:0019900; GO:0019901; GO:0031072; GO:0050821; GO:0051087; GO:0051604; GO:0051879; GO:0060334; GO:0060338; GO:0070062; GO:0097110; GO:0101031; GO:1905091; GO:1990565
GN014498	GN014498.1	Q60HD1	58.4	471	478	473	8.24e-200	565	SPTC1_MACFA	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	ceramide biosynthetic process [GO:0046513]; regulation of fat cell apoptotic process [GO:1904649]; sphingolipid metabolic process [GO:0006665]; sphingosine biosynthetic process [GO:0046512]	pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758]	endoplasmic reticulum membrane [GO:0005789]; serine palmitoyltransferase complex [GO:0017059]	GO:0004758; GO:0005789; GO:0006665; GO:0017059; GO:0030170; GO:0046512; GO:0046513; GO:1904649
GN014499	GN014499.1	Q00472	36.4	291	341	298	4.66e-49	169	PGP_SCHPO	Phosphoglycolate phosphatase (EC 3.1.3.18)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	cellular detoxification [GO:1990748]	alkaline phosphatase activity [GO:0004035]; phosphatase activity [GO:0016791]; phosphoglycolate phosphatase activity [GO:0008967]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004035; GO:0005634; GO:0005829; GO:0008967; GO:0016791; GO:1990748
GN014501	GN014501.1	Q99MZ3	33.0	176	372	864	1.19e-18	91.3	MLXPL_MOUSE	Carbohydrate-responsive element-binding protein (ChREBP) (MLX interactor) (MLX-interacting protein-like) (Williams-Beuren syndrome chromosomal region 14 protein homolog)	Mus musculus (Mouse)	cellular response to glucose stimulus [GO:0071333]; energy homeostasis [GO:0097009]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; glucose mediated signaling pathway [GO:0010255]; lipid biosynthetic process [GO:0008610]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of glycolytic process [GO:0045821]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of glycolytic process [GO:0006110]; regulation of transcription by RNA polymerase II [GO:0006357]; response to glucose [GO:0009749]	carbohydrate response element binding [GO:0035538]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000432; GO:0000785; GO:0000978; GO:0000981; GO:0001216; GO:0001227; GO:0001228; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005829; GO:0006110; GO:0006357; GO:0008284; GO:0008610; GO:0009749; GO:0010255; GO:0019901; GO:0035538; GO:0035774; GO:0042593; GO:0043565; GO:0045723; GO:0045821; GO:0045892; GO:0045893; GO:0045944; GO:0046889; GO:0046982; GO:0055089; GO:0061629; GO:0071333; GO:0090324; GO:0090575; GO:0097009; GO:0140297; GO:1901797
GN014502	GN014502.1	Q5R9B8	38.3	992	1173	860	8.94e-175	540	DCAF6_PONAB	DDB1- and CUL4-associated factor 6 (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0016567; GO:0045944; GO:0080008
GN014508	GN014508.1	Q6NUC1	44.4	99	120	111	1.74e-19	80.1	CNFNA_XENLA	Cornifelin homolog A	Xenopus laevis (African clawed frog)				
GN014509	GN014509.1	Q3ZCB2	42.2	116	121	116	6.91e-23	89.0	PLAC8_BOVIN	Placenta-specific gene 8 protein	Bos taurus (Bovine)	positive regulation of transcription by RNA polymerase II [GO:0045944]			GO:0045944
GN014511	GN014511.1	O22943	27.9	452	781	771	7.49e-39	158	STL1_ARATH	Probable glycosyltransferase STELLO1 (EC 2.4.-.-)	Arabidopsis thaliana (Mouse-ear cress)	intracellular protein localization [GO:0008104]; plant-type cell wall cellulose biosynthetic process [GO:0052324]; regulation of plant-type cell wall cellulose biosynthetic process [GO:2001009]	identical protein binding [GO:0042802]	chloroplast [GO:0009507]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0005768; GO:0005794; GO:0005802; GO:0008104; GO:0009507; GO:0042802; GO:0052324; GO:2001009
GN014514	GN014514.1	Q23157	22.5	373	419	465	3.66e-18	89.7	INX11_CAEEL	Innexin-11 (Protein opu-11)	Caenorhabditis elegans		gap junction channel activity [GO:0005243]; gap junction hemi-channel activity [GO:0055077]	gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0005243; GO:0005886; GO:0005921; GO:0055077
GN014521	GN014521.1	G5EFX6	30.8	182	716	1410	2.87e-10	67.8	SLIT1_CAEEL	Slit homolog 1 protein (Slt-1)	Caenorhabditis elegans	axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dorsal/ventral axon guidance [GO:0033563]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neuron migration [GO:0001764]; regulation of sensory neuron axon guidance [GO:1905489]; sensory neuron axon guidance [GO:0097374]	calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0001764; GO:0005102; GO:0005509; GO:0005576; GO:0007411; GO:0008201; GO:0016199; GO:0033563; GO:0048495; GO:0048843; GO:0097374; GO:1905489
GN014522	GN014522.1	G5EFX6	29.1	179	718	1410	1.48e-09	65.5	SLIT1_CAEEL	Slit homolog 1 protein (Slt-1)	Caenorhabditis elegans	axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dorsal/ventral axon guidance [GO:0033563]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neuron migration [GO:0001764]; regulation of sensory neuron axon guidance [GO:1905489]; sensory neuron axon guidance [GO:0097374]	calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0001764; GO:0005102; GO:0005509; GO:0005576; GO:0007411; GO:0008201; GO:0016199; GO:0033563; GO:0048495; GO:0048843; GO:0097374; GO:1905489
GN014523	GN014523.1	Q91755	38.1	819	853	913	2.26e-183	553	GRIK2_XENLA	Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)	Xenopus laevis (African clawed frog)	detection of cold stimulus involved in thermoception [GO:0120169]; modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]	extracellularly glutamate-gated ion channel activity [GO:0005234]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	kainate selective glutamate receptor complex [GO:0032983]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]	GO:0004970; GO:0005234; GO:0005886; GO:0015277; GO:0022849; GO:0032983; GO:0035249; GO:0042734; GO:0050804; GO:0098839; GO:0120169; GO:1904315
GN014525	GN014525.1	Q9UGM3	37.7	1005	1002	2413	1.29e-194	622	DMBT1_HUMAN	Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Deleted in malignant brain tumors 1 protein) (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein)	Homo sapiens (Human)	defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]	calcium-dependent protein binding [GO:0048306]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]; phagocytic vesicle membrane [GO:0030670]; zymogen granule membrane [GO:0042589]	GO:0005044; GO:0005576; GO:0005737; GO:0030670; GO:0030855; GO:0031012; GO:0035375; GO:0038187; GO:0042589; GO:0043152; GO:0045087; GO:0048306; GO:0050829; GO:0050830; GO:0070062; GO:0140144
GN014526	GN014526.1	Q86SQ9	62.9	275	335	333	5.96e-119	349	DHDDS_HUMAN	Dehydrodolichyl diphosphate synthase complex subunit DHDDS (EC 2.5.1.87) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Cis-prenyltransferase subunit hCIT) (Epididymis tissue protein Li 189m)	Homo sapiens (Human)	dolichyl diphosphate biosynthetic process [GO:0006489]; dolichyl monophosphate biosynthetic process [GO:0043048]; polyprenol biosynthetic process [GO:0016094]	ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity [GO:0045547]	dehydrodolichyl diphosphate synthase complex [GO:1904423]; endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0006489; GO:0016094; GO:0043048; GO:0045547; GO:1904423
GN014527	GN014527.1	Q921C3	49.3	1454	1797	2304	0.0	1228	BRWD1_MOUSE	Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9)	Mus musculus (Mouse)	cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription by RNA polymerase II [GO:0006357]		axoneme [GO:0005930]; cytosol [GO:0005829]; motile cilium [GO:0031514]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0005930; GO:0006357; GO:0007010; GO:0008360; GO:0031514
GN014528	GN014528.1	Q3UHX9	65.2	313	375	385	3.37e-141	409	SPOUT_MOUSE	28S rRNA (uridine-N(3))-methyltransferase (EC 2.1.1.-) (Centromere protein 32) (CENP-32) (Kinetochore-associated protein) (Methyltransferase C9orf114 homolog) (SPOUT domain-containing methyltransferase 1)	Mus musculus (Mouse)	maintenance of centrosome location [GO:0051661]; miRNA processing [GO:0035196]; post-transcriptional regulation of gene expression [GO:0010608]; rRNA base methylation [GO:0070475]	methyltransferase activity [GO:0008168]; miRNA binding [GO:0035198]; RNA methyltransferase activity [GO:0008173]; rRNA (uridine-N3-)-methyltransferase activity [GO:0070042]; S-adenosyl-L-methionine binding [GO:1904047]	kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; spindle pole centrosome [GO:0031616]	GO:0000776; GO:0008168; GO:0008173; GO:0010608; GO:0031616; GO:0035196; GO:0035198; GO:0051661; GO:0070042; GO:0070475; GO:0072686; GO:1904047
GN014539	GN014539.1	Q32PF3	46.9	147	175	178	1.49e-27	104	PCNP_BOVIN	PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein)	Bos taurus (Bovine)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]		nucleus [GO:0005634]	GO:0005634; GO:0016567; GO:0043161
GN014540	GN014540.1	A0A2B4RNI3	32.4	182	663	688	3.57e-22	105	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014543	GN014543.1	Q9CW42	33.0	300	316	340	6.77e-49	169	MARC1_MOUSE	Mitochondrial amidoxime-reducing component 1 (mARC1) (EC 1.7.-.-) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 1) (MOSC domain-containing protein 1) (Moco sulfurase C-terminal domain-containing protein 1)	Mus musculus (Mouse)	cellular detoxification of nitrogen compound [GO:0070458]; nitrate metabolic process [GO:0042126]; nitric oxide biosynthetic process [GO:0006809]	molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940]; nitrite reductase (NO-forming) activity [GO:0050421]; nitrite reductase activity [GO:0098809]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; pyridoxal phosphate binding [GO:0030170]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nitric-oxide synthase complex [GO:1903958]	GO:0005739; GO:0005741; GO:0005743; GO:0006809; GO:0008940; GO:0016020; GO:0016661; GO:0030151; GO:0030170; GO:0042126; GO:0043546; GO:0050421; GO:0070458; GO:0098809; GO:1903958
GN014546	GN014546.1	P82931	36.5	96	143	124	8.84e-14	66.6	RT06_BOVIN	Small ribosomal subunit protein bS6m (28S ribosomal protein S6, mitochondrial) (MRP-S6) (S6mt)	Bos taurus (Bovine)	mitochondrial translation [GO:0032543]	small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005763; GO:0032543; GO:0070181
GN014553	GN014553.1	Q9HAR2	25.9	683	1485	1447	2.18e-43	177	AGRL3_HUMAN	Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion [GO:0098609]; excitatory synapse assembly [GO:1904861]; G protein-coupled receptor signaling pathway [GO:0007186]; neuron migration [GO:0001764]; Rho-activating G protein-coupled receptor signaling pathway [GO:0160221]; synapse assembly [GO:0007416]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; cell adhesion mediator activity [GO:0098631]; G protein-coupled receptor activity [GO:0004930]; molecular condensate scaffold activity [GO:0140693]	anchoring junction [GO:0070161]; axon [GO:0030424]; cell-cell junction [GO:0005911]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0001764; GO:0004930; GO:0005509; GO:0005886; GO:0005911; GO:0007166; GO:0007186; GO:0007189; GO:0007416; GO:0016020; GO:0030246; GO:0030424; GO:0045211; GO:0070161; GO:0098609; GO:0098631; GO:0098978; GO:0140693; GO:0160221; GO:1904861
GN014555	GN014555.1	O61577	56.8	563	545	516	1.18e-190	546	KTNA1_STRPU	Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin)	Strongylocentrotus purpuratus (Purple sea urchin)	microtubule severing [GO:0051013]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule binding [GO:0008017]; microtubule severing ATPase activity [GO:0008568]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; spindle [GO:0005819]; spindle pole [GO:0000922]	GO:0000922; GO:0005524; GO:0005737; GO:0005813; GO:0005819; GO:0008017; GO:0008568; GO:0016887; GO:0030496; GO:0051013; GO:0097431
GN014560	GN014560.1	B5XB27	38.5	288	376	294	1.52e-66	215	KFA_SALSA	Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF)	Salmo salar (Atlantic salmon)	'de novo' NAD+ biosynthetic process from L-tryptophan [GO:0034354]	arylformamidase activity [GO:0004061]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004061; GO:0005634; GO:0005829; GO:0034354
GN014564	GN014564.1	Q5AXT5	32.4	312	334	745	7.16e-44	163	PIF1_EMENI	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]	GO:0000723; GO:0003697; GO:0005524; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0043139; GO:0043596; GO:0071932
GN014565	GN014565.1	Q8K0U4	22.8	474	484	675	2.48e-24	110	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN014570	GN014570.1	Q8K0U4	22.2	474	448	675	1.81e-15	82.4	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN014571	GN014571.1	Q8BR93	42.1	95	135	349	3.63e-14	70.9	HARB1_MOUSE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Mus musculus (Mouse)			centriolar satellite [GO:0034451]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005829; GO:0005886; GO:0034451
GN014573	GN014573.1	O43301	26.2	141	218	675	1.13e-10	63.9	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN014574	GN014574.1	Q8K0U4	21.8	473	470	675	9.62e-20	95.9	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN014575	GN014575.1	Q56A18	50.0	240	610	376	5.56e-63	215	SMCE1_RAT	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57)	Rattus norvegicus (Rat)	chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; neurogenesis [GO:0022008]; spermatid development [GO:0007286]	ATP-dependent chromatin remodeler activity [GO:0140658]; N-acetyltransferase activity [GO:0008080]; nuclear receptor binding [GO:0016922]; RNA binding [GO:0003723]	nBAF complex [GO:0071565]; npBAF complex [GO:0071564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]	GO:0003723; GO:0005634; GO:0005654; GO:0006338; GO:0007286; GO:0008080; GO:0016514; GO:0016922; GO:0022008; GO:0045892; GO:0071564; GO:0071565; GO:0140658
GN014576	GN014576.1	O95935	50.2	211	423	607	3.11e-65	222	TBX18_HUMAN	T-box transcription factor TBX18 (T-box protein 18)	Homo sapiens (Human)	cell fate specification [GO:0001708]; cochlea morphogenesis [GO:0090103]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural plate anterior/posterior regionalization [GO:0021999]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of SA node cell action potential [GO:0098907]; regulation of transcription by RNA polymerase II [GO:0006357]; sinoatrial node cell development [GO:0060931]; sinoatrial node cell fate commitment [GO:0060930]; sinoatrial node development [GO:0003163]; smooth muscle cell differentiation [GO:0051145]; somitogenesis [GO:0001756]; ureter development [GO:0072189]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription repressor complex [GO:0090571]	GO:0000122; GO:0000785; GO:0000978; GO:0000981; GO:0001227; GO:0001708; GO:0001756; GO:0003163; GO:0005634; GO:0005654; GO:0006357; GO:0016331; GO:0021999; GO:0045893; GO:0051145; GO:0060930; GO:0060931; GO:0072189; GO:0090090; GO:0090103; GO:0090571; GO:0098907; GO:1990837
GN014577	GN014577.1	Q9WTS8	50.0	180	417	335	6.15e-48	169	FCN1_RAT	Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)	Rattus norvegicus (Rat)	cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of interleukin-8 production [GO:0032757]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; pattern recognition receptor activity [GO:0038187]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]	GO:0001867; GO:0002752; GO:0003823; GO:0005102; GO:0005576; GO:0005886; GO:0007186; GO:0009986; GO:0031012; GO:0032757; GO:0033691; GO:0038187; GO:0097367; GO:0106139
GN014581	GN014581.1	P40873	33.1	387	415	389	3.37e-57	195	MSOX_ARTST	Monomeric sarcosine oxidase (MSOX) (EC 1.5.3.1)	Arthrobacter sp. (strain TE1826)		flavin adenine dinucleotide binding [GO:0050660]; sarcosine oxidase activity [GO:0008115]	cytoplasm [GO:0005737]	GO:0005737; GO:0008115; GO:0050660
GN014582	GN014582.1	Q2QKL5	53.3	214	469	479	3.98e-78	254	PCS3_LOTJA	Glutathione gamma-glutamylcysteinyltransferase 3 (EC 2.3.2.15) (LjPCS3-7N) (Phytochelatin synthase 3)	Lotus japonicus (Lotus corniculatus var. japonicus)	cellular detoxification of cadmium ion [GO:0098849]; detoxification of copper ion [GO:0010273]; phytochelatin biosynthetic process [GO:0046938]	glutathione gamma-glutamylcysteinyltransferase activity [GO:0016756]; metal ion binding [GO:0046872]		GO:0010273; GO:0016756; GO:0046872; GO:0046938; GO:0098849
GN014583	GN014583.1	O62640	37.5	299	327	358	8.64e-41	149	PIAP_PIG	Putative inhibitor of apoptosis	Sus scrofa (Pig)	negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; regulation of cell cycle [GO:0051726]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0031398; GO:0033209; GO:0043027; GO:0043066; GO:0043123; GO:0051726; GO:0060546; GO:0061630
GN014584	GN014584.1	P11602	41.5	123	178	490	2.31e-20	90.5	LIPL_CHICK	Lipoprotein lipase (LPL) (EC 3.1.1.34) (Phospholipase A1) (EC 3.1.1.32)	Gallus gallus (Chicken)	cholesterol homeostasis [GO:0042632]; chylomicron remodeling [GO:0034371]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; high-density lipoprotein particle remodeling [GO:0034375]; low-density lipoprotein particle mediated signaling [GO:0055096]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of chemokine production [GO:0032722]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of inflammatory response [GO:0050729]; positive regulation of triglyceride transport [GO:1905885]; triglyceride catabolic process [GO:0019433]; triglyceride homeostasis [GO:0070328]; very-low-density lipoprotein particle remodeling [GO:0034372]	apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; glycerophospholipid phospholipase A1 activity [GO:0008970]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]; lipoprotein lipase activity [GO:0004465]; lipoprotein particle binding [GO:0071813]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; triacylglycerol lipase activity [GO:0004806]	catalytic complex [GO:1902494]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0004465; GO:0004806; GO:0005102; GO:0005509; GO:0005576; GO:0005886; GO:0006631; GO:0006633; GO:0008201; GO:0008970; GO:0010886; GO:0019433; GO:0032722; GO:0034185; GO:0034371; GO:0034372; GO:0034375; GO:0042632; GO:0042803; GO:0043395; GO:0045600; GO:0050729; GO:0055096; GO:0070328; GO:0071813; GO:1902494; GO:1904179; GO:1905885
GN014585	GN014585.1	Q6DDJ5	24.5	477	872	726	2.61e-33	141	WDCP_XENLA	WD repeat and coiled-coil-containing protein	Xenopus laevis (African clawed frog)		kinase binding [GO:0019900]		GO:0019900
GN014586	GN014586.1	Q6DID3	46.7	664	1213	1268	1.35e-80	293	SCAF8_MOUSE	SR-related and CTD-associated factor 8 (RNA-binding motif protein 16)	Mus musculus (Mouse)	mRNA processing [GO:0006397]; negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000805]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; termination of RNA polymerase II transcription [GO:0006369]; transcription by RNA polymerase II [GO:0006366]	mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; RNA polymerase core enzyme binding [GO:0043175]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]; RNA polymerase II complex binding [GO:0000993]	mRNA cleavage factor complex [GO:0005849]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000993; GO:0003723; GO:0003729; GO:0005634; GO:0005654; GO:0005849; GO:0006366; GO:0006369; GO:0006397; GO:0016363; GO:0019904; GO:0032786; GO:0043175; GO:0070063; GO:1990269; GO:2000805
GN014587	GN014587.1	Q6DE40	55.8	351	379	449	7.26e-152	439	MANEA_XENLA	Glycoprotein endo-alpha-1,2-mannosidase (EC 3.2.1.130)	Xenopus laevis (African clawed frog)		alpha-mannosidase activity [GO:0004559]; glycoprotein endo-alpha-1,2-mannosidase activity [GO:0004569]	Golgi membrane [GO:0000139]	GO:0000139; GO:0004559; GO:0004569
GN014588	GN014588.1	Q9NQZ6	63.6	225	228	224	1.86e-86	258	ZC4H2_HUMAN	Zinc finger C4H2 domain-containing protein (Hepatocellular carcinoma-associated antigen 127)	Homo sapiens (Human)	nervous system development [GO:0007399]; neuromuscular junction development [GO:0007528]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein monoubiquitination [GO:0006513]; regulation of transcription regulatory region DNA binding [GO:2000677]; spinal cord motor neuron differentiation [GO:0021522]		cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]	GO:0005634; GO:0005737; GO:0006513; GO:0007399; GO:0007528; GO:0021522; GO:0032991; GO:0043025; GO:0045211; GO:0045666; GO:0045944; GO:2000677
GN014589	GN014589.1	P47813	76.4	144	155	144	2.21e-60	186	IF1AX_HUMAN	Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (eIF1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)	Homo sapiens (Human)	ribosome assembly [GO:0042255]; translational initiation [GO:0006413]	RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; multi-eIF complex [GO:0043614]	GO:0003723; GO:0003743; GO:0005737; GO:0005829; GO:0006413; GO:0008135; GO:0016282; GO:0033290; GO:0042255; GO:0043614
GN014590	GN014590.1	Q9BRZ2	46.5	71	195	755	2.89e-13	70.9	TRI56_HUMAN	E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56)	Homo sapiens (Human)	defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340]	RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0003723; GO:0004842; GO:0005654; GO:0005737; GO:0005829; GO:0006513; GO:0008270; GO:0032479; GO:0032728; GO:0034340; GO:0045087; GO:0045089; GO:0051607; GO:0060340; GO:0061630; GO:0070534; GO:1901224
GN014593	GN014593.1	Q5RDZ2	45.3	106	113	319	1.15e-21	90.1	CRYL1_PONAB	Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	D-glucuronate catabolic process to D-xylulose 5-phosphate [GO:0019640]; fatty acid metabolic process [GO:0006631]	L-gulonate 3-dehydrogenase activity [GO:0050104]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0006631; GO:0019640; GO:0042803; GO:0050104; GO:0070403
GN014594	GN014594.1	Q99KP3	45.0	189	205	319	3.18e-56	183	CRYL1_MOUSE	Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH)	Mus musculus (Mouse)	D-glucuronate catabolic process to D-xylulose 5-phosphate [GO:0019640]; fatty acid metabolic process [GO:0006631]	L-gulonate 3-dehydrogenase activity [GO:0050104]; NAD+ binding [GO:0070403]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0006631; GO:0019640; GO:0042803; GO:0050104; GO:0070403
GN014596	GN014596.1	Q16611	43.6	163	231	211	1.33e-33	123	BAK_HUMAN	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)	Homo sapiens (Human)	animal organ regeneration [GO:0031100]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; endocrine pancreas development [GO:0031018]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of apoptotic process [GO:0043065]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; release of cytochrome c from mitochondria [GO:0001836]; response to ethanol [GO:0045471]; response to hydrogen peroxide [GO:0042542]; response to UV-C [GO:0010225]; response to xenobiotic stimulus [GO:0009410]	BH domain binding [GO:0051400]; channel activity [GO:0015267]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; porin activity [GO:0015288]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transmembrane transporter binding [GO:0044325]	BAK complex [GO:0097145]; Bcl-2 family protein complex [GO:0097136]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; pore complex [GO:0046930]	GO:0001836; GO:0005739; GO:0005741; GO:0005783; GO:0005829; GO:0006915; GO:0008285; GO:0008630; GO:0009410; GO:0010225; GO:0010248; GO:0010629; GO:0015267; GO:0015288; GO:0031018; GO:0031072; GO:0031100; GO:0031334; GO:0032469; GO:0034620; GO:0034644; GO:0042542; GO:0042802; GO:0042803; GO:0043065; GO:0043066; GO:0044325; GO:0044877; GO:0045471; GO:0045862; GO:0046902; GO:0046930; GO:0046982; GO:0051087; GO:0051400; GO:0051881; GO:0070059; GO:0071260; GO:0090200; GO:0090201; GO:0097136; GO:0097145; GO:0097190; GO:0097192; GO:0097193; GO:1901029; GO:1901030; GO:1903896
GN014598	GN014598.1	A0A2B4RNI3	33.3	162	662	688	1.92e-21	102	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014599	GN014599.1	A0A2B4RNI3	33.7	163	662	688	2.68e-22	105	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014600	GN014600.1	A0A2B4RNI3	33.3	162	656	688	3.28e-21	102	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014601	GN014601.1	A0A2B4RNI3	31.3	182	663	688	3.38e-21	102	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014602	GN014602.1	Q9D554	74.5	502	502	501	3.04e-265	733	SF3A3_MOUSE	Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61)	Mus musculus (Mouse)	mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; U2-type prespliceosome assembly [GO:1903241]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]; U2-type spliceosomal complex [GO:0005684]	GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005684; GO:0005686; GO:0006397; GO:0008270; GO:0016607; GO:0071005; GO:0071006; GO:0071011; GO:0071013; GO:1903241
GN014603	GN014603.1	Q99549	38.2	338	813	860	1.49e-19	97.8	MPP8_HUMAN	M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3)	Homo sapiens (Human)	constitutive heterochromatin formation [GO:0140719]; negative regulation of gene expression via chromosomal CpG island methylation [GO:0044027]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of type I interferon production [GO:0032480]; transposable element silencing by heterochromatin formation [GO:0141005]	chromatin binding [GO:0003682]; histone H3K9me2/3 reader activity [GO:0062072]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; HUSH complex [GO:0140283]; HUSH2 complex [GO:0140286]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	GO:0000785; GO:0000786; GO:0000792; GO:0003682; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0032480; GO:0044027; GO:0045814; GO:0062072; GO:0140283; GO:0140286; GO:0140719; GO:0141005
GN014604	GN014604.1	Q922M3	46.9	96	369	315	3.94e-18	87.4	BACD3_MOUSE	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (mBACURD3) (BTB/POZ domain-containing protein KCTD10)	Mus musculus (Mouse)	angiogenesis [GO:0001525]; cilium assembly [GO:0060271]; establishment of endothelial barrier [GO:0061028]; heart development [GO:0007507]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of cilium assembly [GO:0045724]; positive regulation of ferroptosis [GO:0160020]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	identical protein binding [GO:0042802]; Notch binding [GO:0005112]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; MKS complex [GO:0036038]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0001525; GO:0005112; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006511; GO:0007507; GO:0016567; GO:0031463; GO:0035024; GO:0036038; GO:0042802; GO:0043161; GO:0045724; GO:0045746; GO:0051260; GO:0060271; GO:0061028; GO:0160020; GO:1902523; GO:1990756
GN014605	GN014605.1	Q5ZMS3	83.5	473	473	472	2.57e-284	779	IF2G_CHICK	Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma) (eIF2-gamma)	Gallus gallus (Chicken)	cytoplasmic translational initiation [GO:0002183]; formation of translation preinitiation complex [GO:0001731]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; methionyl-initiator methionine tRNA binding [GO:1990856]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic translation initiation factor 2 complex [GO:0005850]	GO:0001731; GO:0002183; GO:0003743; GO:0003924; GO:0005525; GO:0005829; GO:0005850; GO:1990856
GN014606	GN014606.1	O54862	44.4	275	298	510	1.39e-83	263	MBTP2_CRIGR	Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Sterol regulatory element-binding proteins intramembrane protease) (SREBPs intramembrane protease)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	bone maturation [GO:0070977]; membrane protein intracellular domain proteolysis [GO:0031293]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein maturation [GO:0051604]; regulation of response to endoplasmic reticulum stress [GO:1905897]; response to endoplasmic reticulum stress [GO:0034976]	metalloendopeptidase activity [GO:0004222]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription regulator activator activity [GO:0140537]	cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0004222; GO:0005737; GO:0007095; GO:0016020; GO:0031293; GO:0034976; GO:0045542; GO:0045944; GO:0051604; GO:0061629; GO:0070977; GO:0140537; GO:1905897
GN014607	GN014607.1	A0A2B4RNI3	31.9	182	660	688	8.19e-22	103	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014610	GN014610.1	Q16827	43.0	114	139	1216	8.24e-28	110	PTPRO_HUMAN	Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2)	Homo sapiens (Human)	axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; glomerulus development [GO:0032835]; lamellipodium assembly [GO:0030032]; monocyte chemotaxis [GO:0002548]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of glomerular filtration [GO:0003105]; negative regulation of neuron projection development [GO:0010977]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; podocyte differentiation [GO:0072112]; regulation of glomerular filtration [GO:0003093]; regulation of synapse organization [GO:0050807]; slit diaphragm assembly [GO:0036060]	cadherin binding [GO:0045296]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; Wnt-protein binding [GO:0017147]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	GO:0000902; GO:0002548; GO:0003093; GO:0003105; GO:0004725; GO:0005001; GO:0005886; GO:0007411; GO:0010812; GO:0010977; GO:0016020; GO:0016324; GO:0016328; GO:0016791; GO:0017147; GO:0030027; GO:0030032; GO:0030424; GO:0030426; GO:0032835; GO:0036060; GO:0042803; GO:0043005; GO:0043197; GO:0045296; GO:0050807; GO:0070062; GO:0072112; GO:0090090; GO:0090260; GO:0098839; GO:0098978; GO:0098982
GN014612	GN014612.1	Q9IBG7	44.2	658	678	2327	1.97e-213	659	KCP_XENLA	Kielin/chordin-like protein (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin)	Xenopus laevis (African clawed frog)	heart valve development [GO:0003170]; positive regulation of BMP signaling pathway [GO:0030513]		extracellular region [GO:0005576]	GO:0003170; GO:0005576; GO:0030513
GN014613	GN014613.1	Q28BX9	45.1	1136	1111	1014	3.77e-294	851	C2CD5_XENTR	C2 domain-containing protein 5 (138 kDa C2 domain-containing phosphoprotein)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	insulin receptor signaling pathway [GO:0008286]; intracellular protein transmembrane transport [GO:0065002]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of vesicle fusion [GO:0031340]; protein localization to plasma membrane [GO:0072659]	calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]	cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	GO:0005509; GO:0005544; GO:0005886; GO:0005938; GO:0008286; GO:0010828; GO:0030659; GO:0031340; GO:0032587; GO:0065002; GO:0072659; GO:0090314
GN014614	GN014614.1	Q5F4B1	38.1	315	312	312	2.46e-61	200	PGP_CHICK	Phosphoglycolate phosphatase (EC 3.1.3.18) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Glycerol-3-phosphate phosphatase) (G3PP) (EC 3.1.3.21)	Gallus gallus (Chicken)	glycerol biosynthetic process [GO:0006114]; glycerophospholipid metabolic process [GO:0006650]; negative regulation of gluconeogenesis [GO:0045721]; toxic metabolite repair [GO:0110052]	phosphoglycolate phosphatase activity [GO:0008967]; protein tyrosine phosphatase activity [GO:0004725]; sn-glycerol 1-phosphatase activity [GO:0000121]; sn-glycerol 3-phosphatase activity [GO:0043136]		GO:0000121; GO:0004725; GO:0006114; GO:0006650; GO:0008967; GO:0043136; GO:0045721; GO:0110052
GN014622	GN014622.1	Q96D71	34.2	436	817	796	1.23e-54	206	REPS1_HUMAN	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)	Homo sapiens (Human)		calcium ion binding [GO:0005509]; protein-macromolecule adaptor activity [GO:0030674]; SH3 domain binding [GO:0017124]	clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0005509; GO:0005829; GO:0005886; GO:0005905; GO:0017124; GO:0030674
GN014624	GN014624.1	Q3MHL3	81.7	415	426	425	4.53e-224	623	RBBP4_BOVIN	Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4)	Bos taurus (Bovine)	DNA replication-dependent chromatin assembly [GO:0006335]	histone binding [GO:0042393]	CAF-1 complex [GO:0033186]; chromosome, telomeric region [GO:0000781]; ESC/E(Z) complex [GO:0035098]; nucleus [GO:0005634]; NuRD complex [GO:0016581]	GO:0000781; GO:0005634; GO:0006335; GO:0016581; GO:0033186; GO:0035098; GO:0042393
GN014627	GN014627.1	Q6NU46	69.8	235	250	420	1.50e-101	304	THILA_XENLA	Acetyl-CoA acetyltransferase A, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase A)	Xenopus laevis (African clawed frog)	fatty acid beta-oxidation [GO:0006635]	acetyl-CoA C-acetyltransferase activity [GO:0003985]	mitochondrion [GO:0005739]	GO:0003985; GO:0005739; GO:0006635
GN014628	GN014628.1	A0A2B4RNI3	32.7	162	658	688	2.50e-21	102	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014629	GN014629.1	Q8QZT1	75.0	48	127	424	6.48e-17	78.6	THIL_MOUSE	Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase)	Mus musculus (Mouse)	acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA catabolic process [GO:0046356]; adipose tissue development [GO:0060612]; coenzyme A biosynthetic process [GO:0015937]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; ketone body catabolic process [GO:0046952]; L-isoleucine catabolic process [GO:0006550]; liver development [GO:0001889]; metanephric proximal convoluted tubule development [GO:0072229]; propionyl-CoA biosynthetic process [GO:1902860]; response to hormone [GO:0009725]; response to starvation [GO:0042594]	acetyl-CoA C-acetyltransferase activity [GO:0003985]; C-acetyltransferase activity [GO:0016453]; cholesterol O-acyltransferase activity [GO:0034736]; coenzyme A binding [GO:0120225]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; potassium ion binding [GO:0030955]	endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0001889; GO:0003985; GO:0005739; GO:0005743; GO:0005759; GO:0005783; GO:0006085; GO:0006550; GO:0006635; GO:0009725; GO:0015936; GO:0015937; GO:0016453; GO:0019899; GO:0030955; GO:0034736; GO:0042594; GO:0042802; GO:0046356; GO:0046952; GO:0060612; GO:0072229; GO:0120225; GO:1902860
GN014630	GN014630.1	Q8QZT1	76.6	47	50	424	4.59e-18	78.2	THIL_MOUSE	Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase)	Mus musculus (Mouse)	acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA catabolic process [GO:0046356]; adipose tissue development [GO:0060612]; coenzyme A biosynthetic process [GO:0015937]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; ketone body catabolic process [GO:0046952]; L-isoleucine catabolic process [GO:0006550]; liver development [GO:0001889]; metanephric proximal convoluted tubule development [GO:0072229]; propionyl-CoA biosynthetic process [GO:1902860]; response to hormone [GO:0009725]; response to starvation [GO:0042594]	acetyl-CoA C-acetyltransferase activity [GO:0003985]; C-acetyltransferase activity [GO:0016453]; cholesterol O-acyltransferase activity [GO:0034736]; coenzyme A binding [GO:0120225]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; potassium ion binding [GO:0030955]	endoplasmic reticulum [GO:0005783]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0001889; GO:0003985; GO:0005739; GO:0005743; GO:0005759; GO:0005783; GO:0006085; GO:0006550; GO:0006635; GO:0009725; GO:0015936; GO:0015937; GO:0016453; GO:0019899; GO:0030955; GO:0034736; GO:0042594; GO:0042802; GO:0046356; GO:0046952; GO:0060612; GO:0072229; GO:0120225; GO:1902860
GN014631	GN014631.1	A0A2B4RNI3	34.2	152	662	688	1.28e-19	97.1	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014632	GN014632.1	A0A2B4RNI3	30.1	206	658	688	4.38e-21	101	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014634	GN014634.1	A0A2B4RNI3	30.2	182	679	688	1.46e-20	100	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014636	GN014636.1	A0A2B4RNI3	31.7	180	664	688	4.49e-21	101	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN014645	GN014645.1	Q9H446	49.4	231	234	243	2.95e-53	174	RWDD1_HUMAN	RWD domain-containing protein 1 (DRG family-regulatory protein 2)	Homo sapiens (Human)	androgen receptor signaling pathway [GO:0030521]; cytoplasmic translation [GO:0002181]	transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]	GO:0002181; GO:0003713; GO:0005829; GO:0030521
GN014646	GN014646.1	A4FUI1	50.8	132	151	144	5.32e-36	124	MIX23_BOVIN	Protein MIX23 (Coiled-coil domain-containing protein 58)	Bos taurus (Bovine)			mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]	GO:0005739; GO:0005758
GN014647	GN014647.1	O15131	75.3	530	542	539	1.48e-149	442	IMA6_HUMAN	Importin subunit alpha-6 (Karyopherin subunit alpha-5)	Homo sapiens (Human)	NLS-bearing protein import into nucleus [GO:0006607]	nuclear import signal receptor activity [GO:0061608]	cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005829; GO:0006607; GO:0042564; GO:0061608
GN014656	GN014656.1	Q06234	55.1	156	207	199	8.32e-35	125	ASCL1_XENLA	Achaete-scute homolog 1 (XASH1)	Xenopus laevis (African clawed frog)	nervous system development [GO:0007399]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory organ development [GO:0007423]; ventral spinal cord interneuron fate commitment [GO:0060579]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000977; GO:0000981; GO:0003700; GO:0005634; GO:0006357; GO:0007399; GO:0007423; GO:0030182; GO:0045666; GO:0045944; GO:0046983; GO:0048663; GO:0048665; GO:0048666; GO:0050767; GO:0060579; GO:0090575
GN014658	GN014658.1	Q06234	45.4	185	199	199	5.70e-33	120	ASCL1_XENLA	Achaete-scute homolog 1 (XASH1)	Xenopus laevis (African clawed frog)	nervous system development [GO:0007399]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory organ development [GO:0007423]; ventral spinal cord interneuron fate commitment [GO:0060579]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000977; GO:0000981; GO:0003700; GO:0005634; GO:0006357; GO:0007399; GO:0007423; GO:0030182; GO:0045666; GO:0045944; GO:0046983; GO:0048663; GO:0048665; GO:0048666; GO:0050767; GO:0060579; GO:0090575
GN014659	GN014659.1	Q90259	53.2	62	221	196	4.10e-10	60.5	ASL1A_DANRE	Achaete-scute homolog 1a (Zash-1a) (Pituitary-absent protein)	Danio rerio (Zebrafish) (Brachydanio rerio)	adenohypophysis development [GO:0021984]; axon regeneration [GO:0031103]; cell dedifferentiation [GO:0043697]; embryonic digestive tract development [GO:0048566]; epithelial cell maturation [GO:0002070]; hindbrain morphogenesis [GO:0021575]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of gene expression [GO:0010629]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regeneration [GO:0031099]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory epithelium regeneration [GO:0070654]; sensory organ development [GO:0007423]; sympathetic ganglion development [GO:0061549]; taste bud formation [GO:0061195]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000977; GO:0000981; GO:0002070; GO:0005634; GO:0006357; GO:0007399; GO:0007423; GO:0010629; GO:0021575; GO:0021984; GO:0030182; GO:0031099; GO:0031103; GO:0043565; GO:0043697; GO:0045666; GO:0045893; GO:0045944; GO:0046983; GO:0048566; GO:0050767; GO:0060575; GO:0061195; GO:0061549; GO:0070654; GO:0090575
GN014661	GN014661.1	Q32PJ3	53.1	147	149	712	1.31e-46	163	ORC3_BOVIN	Origin recognition complex subunit 3	Bos taurus (Bovine)	DNA replication initiation [GO:0006270]; regulation of DNA replication [GO:0006275]	DNA replication origin binding [GO:0003688]	chromatin [GO:0000785]; chromosome [GO:0005694]; DNA replication preinitiation complex [GO:0031261]; nuclear origin of replication recognition complex [GO:0005664]; nuclear pre-replicative complex [GO:0005656]; nucleus [GO:0005634]	GO:0000785; GO:0003688; GO:0005634; GO:0005656; GO:0005664; GO:0005694; GO:0006270; GO:0006275; GO:0031261
GN014664	GN014664.1	Q2T9T0	36.7	449	457	428	2.37e-72	237	SAXO4_BOVIN	Stabilizer of axonemal microtubules 4 (Protein phosphatase 1 regulatory subunit 32)	Bos taurus (Bovine)	flagellated sperm motility [GO:0030317]	phosphatase binding [GO:0019902]	axonemal A tubule inner sheath [GO:0160111]; cilium [GO:0005929]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]	GO:0005737; GO:0005929; GO:0019902; GO:0030317; GO:0036126; GO:0160111
GN014665	GN014665.1	F1NTD6	62.4	603	608	2211	9.15e-258	772	ASCC3_CHICK	Activating signal cointegrator 1 complex subunit 3 (EC 5.6.2.4)	Gallus gallus (Chicken)	DNA alkylation repair [GO:0006307]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; DNA repair complex [GO:1990391]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; RQC-trigger complex [GO:0180022]	GO:0003723; GO:0005524; GO:0005634; GO:0005829; GO:0006307; GO:0016607; GO:0016887; GO:0022626; GO:0032790; GO:0043138; GO:0072344; GO:0180022; GO:1990116; GO:1990391
GN014666	GN014666.1	O16374	28.1	385	458	425	1.05e-35	140	GALT1_CAEEL	Beta-1,4-galactosyltransferase galt-1 (EC 2.4.1.-)	Caenorhabditis elegans	carbohydrate derivative biosynthetic process [GO:1901137]; N-glycan processing [GO:0006491]	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; UDP-galactosyltransferase activity [GO:0035250]	Golgi cisterna membrane [GO:0032580]	GO:0003831; GO:0006491; GO:0032580; GO:0035250; GO:1901137
GN014669	GN014669.1	H0VCJ6	43.5	322	335	354	1.29e-89	275	NAAA_CAVPO	N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.60) (Acylsphingosine deacylase NAAA) (EC 3.5.1.23) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta]	Cavia porcellus (Guinea pig)	fatty acid metabolic process [GO:0006631]; N-acylethanolamine metabolic process [GO:0070291]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; sphingosine metabolic process [GO:0006670]	fatty acid amide hydrolase activity [GO:0017064]; N-(long-chain-acyl)ethanolamine deacylase activity [GO:0047412]; N-acylsphingosine amidohydrolase activity [GO:0017040]	lysosome [GO:0005764]; membrane [GO:0016020]	GO:0005764; GO:0006631; GO:0006670; GO:0016020; GO:0017040; GO:0017064; GO:0047412; GO:0070291; GO:0070292
GN014670	GN014670.1	Q80Y44	52.4	729	852	875	2.72e-229	670	DDX10_MOUSE	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10)	Mus musculus (Mouse)	anterior head development [GO:0097065]; rRNA processing [GO:0006364]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003676; GO:0003724; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0006364; GO:0016887; GO:0097065
GN014671	GN014671.1	P43143	33.6	327	423	493	8.92e-63	213	ACHA6_RAT	Neuronal acetylcholine receptor subunit alpha-6	Rattus norvegicus (Rat)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0014059; GO:0022848; GO:0030594; GO:0032991; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN014676	GN014676.1	Q8VIJ6	55.8	251	520	699	1.27e-84	279	SFPQ_MOUSE	Splicing factor, proline- and glutamine-rich (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)	Mus musculus (Mouse)	activation of innate immune response [GO:0002218]; alternative mRNA splicing, via spliceosome [GO:0000380]; chromatin remodeling [GO:0006338]; chromosome organization [GO:0051276]; dendritic transport of messenger ribonucleoprotein complex [GO:0098963]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of sister chromatid cohesion [GO:0045876]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone deacetylase binding [GO:0042826]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000380; GO:0000724; GO:0000785; GO:0000976; GO:0002218; GO:0003677; GO:0003682; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006338; GO:0006355; GO:0006974; GO:0016363; GO:0016607; GO:0030425; GO:0042382; GO:0042752; GO:0042754; GO:0042803; GO:0042826; GO:0045876; GO:0045892; GO:0045944; GO:0051276; GO:0051726; GO:0090575; GO:0098963; GO:1902177
GN014678	GN014678.1	A5PK71	83.7	221	244	257	3.95e-135	383	PACRG_BOVIN	Parkin coregulated gene protein	Bos taurus (Bovine)	flagellated sperm motility [GO:0030317]	actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; G protein-coupled receptor binding [GO:0001664]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; ubiquitin protein ligase binding [GO:0031625]	axonemal B tubule inner sheath [GO:0160112]; axonemal microtubule [GO:0005879]; cell body [GO:0044297]; cytosol [GO:0005829]; manchette [GO:0002177]; neuron projection [GO:0043005]; sperm end piece [GO:0097229]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; vesicle [GO:0031982]	GO:0001664; GO:0002177; GO:0003779; GO:0005829; GO:0005879; GO:0030317; GO:0030544; GO:0031625; GO:0031982; GO:0043005; GO:0043014; GO:0044297; GO:0048487; GO:0051879; GO:0097225; GO:0097228; GO:0097229; GO:0160112
GN014679	GN014679.1	A1ZAY1	43.1	281	605	355	1.36e-54	192	DLISH_DROME	SH3 domain-containing protein Dlish (Dachs ligand with SH3 domains)	Drosophila melanogaster (Fruit fly)	establishment of epithelial cell planar polarity [GO:0090163]; establishment of planar polarity [GO:0001736]; negative regulation of hippo signaling [GO:0035331]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein localization involved in establishment of planar polarity [GO:0090251]	cadherin binding [GO:0045296]	apical cortex [GO:0045179]; apicolateral plasma membrane [GO:0016327]; cilium [GO:0005929]; cytoplasm [GO:0005737]; subapical part of cell [GO:0120219]	GO:0001736; GO:0005737; GO:0005929; GO:0016327; GO:0032436; GO:0035331; GO:0045179; GO:0045296; GO:0090163; GO:0090251; GO:0120219
GN014681	GN014681.1	Q9Z2I6	33.7	584	532	727	3.73e-108	342	SV2C_RAT	Synaptic vesicle glycoprotein 2C (Synaptic vesicle protein 2C)	Rattus norvegicus (Rat)	chemical synaptic transmission [GO:0007268]; negative regulation of excitatory postsynaptic potential [GO:0090394]; regulation of synaptic vesicle exocytosis [GO:2000300]	transmembrane transporter activity [GO:0022857]	dopaminergic synapse [GO:0098691]; nucleoplasm [GO:0005654]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	GO:0005654; GO:0007268; GO:0008021; GO:0022857; GO:0030672; GO:0090394; GO:0098691; GO:2000300
GN014683	GN014683.1	P18173	38.3	493	495	612	7.59e-92	295	DHGL_DROME	Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]	Drosophila melanogaster (Fruit fly)	glucose metabolic process [GO:0006006]; pupal chitin-based cuticle development [GO:0008364]; sperm storage [GO:0046693]	flavin adenine dinucleotide binding [GO:0050660]; glucose dehydrogenase (FAD, quinone) activity [GO:0140762]; oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0006006; GO:0008364; GO:0016491; GO:0046693; GO:0050660; GO:0140762
GN014687	GN014687.1	Q9PUK5	61.6	138	597	465	2.38e-44	167	PAX8_XENLA	Paired box protein Pax-8 (XPax-8)	Xenopus laevis (African clawed frog)	cell proliferation involved in pronephros development [GO:0039015]; cellular response to retinoic acid [GO:0071300]; metanephric nephron tubule development [GO:0072234]; metanephros development [GO:0001656]; nervous system development [GO:0007399]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of thyroid hormone generation [GO:2000611]; pronephric field specification [GO:0039003]; pronephric nephron tubule development [GO:0039020]; pronephros development [GO:0048793]; proximal tubule development [GO:0072014]; regulation of apoptotic process [GO:0042981]; regulation of pronephros size [GO:0035565]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory organ development [GO:0007423]; urogenital system development [GO:0001655]; Wnt signaling pathway [GO:0016055]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000976; GO:0000978; GO:0000981; GO:0001655; GO:0001656; GO:0005634; GO:0005654; GO:0006357; GO:0007399; GO:0007423; GO:0016055; GO:0035565; GO:0039003; GO:0039015; GO:0039020; GO:0042981; GO:0045893; GO:0048793; GO:0071300; GO:0072014; GO:0072234; GO:2000611
GN014690	GN014690.1	Q53FA7	55.6	331	340	332	2.27e-117	345	QORX_HUMAN	Quinone oxidoreductase PIG3 (EC 1.6.5.5) (NADPH:quinone reductase PIG3) (Tumor protein p53-inducible protein 3) (Protein PIG3) (p53-induced gene 3 protein)	Homo sapiens (Human)	apoptotic process [GO:0006915]; reactive oxygen species biosynthetic process [GO:1903409]	quinone reductase (NADPH) activity [GO:0003960]	cytosol [GO:0005829]	GO:0003960; GO:0005829; GO:0006915; GO:1903409
GN014692	GN014692.1	Q6GLJ1	26.1	459	471	470	1.59e-37	146	BTBDH_XENLA	BTB/POZ domain-containing protein 17	Xenopus laevis (African clawed frog)			extracellular region [GO:0005576]	GO:0005576
GN014694	GN014694.1	A0A1D5NSM8	28.0	218	652	3615	5.61e-09	63.5	SVEP1_DANRE	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)	Danio rerio (Zebrafish) (Brachydanio rerio)	cell migration [GO:0016477]; epidermal cell differentiation [GO:0009913]; epidermis development [GO:0008544]; epithelial cell-cell adhesion [GO:0090136]; lymph vessel development [GO:0001945]; lymph vessel morphogenesis [GO:0036303]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0001945; GO:0005509; GO:0005576; GO:0005634; GO:0005737; GO:0008544; GO:0009913; GO:0016020; GO:0016477; GO:0036303; GO:0090136
GN014695	GN014695.1	Q63184	30.1	335	441	513	3.42e-31	128	E2AK2_RAT	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2)	Rattus norvegicus (Rat)	antiviral innate immune response [GO:0140374]; cellular response to amino acid starvation [GO:0034198]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of NLRP3 inflammasome complex assembly [GO:1900225]; regulation of translational initiation [GO:0006446]; response to exogenous dsRNA [GO:0043330]; response to interferon-alpha [GO:0035455]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; response to vitamin E [GO:0033197]; translation [GO:0006412]	ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0001819; GO:0003725; GO:0004672; GO:0004674; GO:0004694; GO:0004715; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006412; GO:0006446; GO:0006468; GO:0009612; GO:0009615; GO:0009636; GO:0016301; GO:0017148; GO:0030968; GO:0032496; GO:0032722; GO:0032874; GO:0033197; GO:0033689; GO:0034198; GO:0035455; GO:0042802; GO:0043065; GO:0043066; GO:0043123; GO:0043330; GO:0043410; GO:0045071; GO:0046777; GO:0048471; GO:0106310; GO:0140374; GO:1900225; GO:1901224; GO:1901532; GO:1902033; GO:1902036; GO:2000766
GN014704	GN014704.1	Q498J9	41.8	201	466	233	1.34e-45	161	MBLC1_XENLA	Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1)	Xenopus laevis (African clawed frog)	histone mRNA metabolic process [GO:0008334]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0008334; GO:0046872; GO:1900087
GN014706	GN014706.1	Q6TGS6	67.3	444	438	529	2.55e-204	577	SYYC_DANRE	Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA damage response [GO:0006974]; tyrosyl-tRNA aminoacylation [GO:0006437]	ATP binding [GO:0005524]; tRNA binding [GO:0000049]; tyrosine-tRNA ligase activity [GO:0004831]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000049; GO:0004831; GO:0005524; GO:0005634; GO:0005737; GO:0006437; GO:0006974
GN014707	GN014707.1	P11029	67.8	2261	2360	2324	0.0	3079	ACAC_CHICK	Acetyl-CoA carboxylase (ACC) (EC 6.4.1.2) [Includes: Biotin carboxylase (EC 6.3.4.14)]	Gallus gallus (Chicken)	epigenetic regulation of gene expression [GO:0040029]; fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; response to carbohydrate [GO:0009743]; response to fatty acid [GO:0070542]; response to thyroid hormone [GO:0097066]	acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; biotin binding [GO:0009374]; biotin carboxylase activity [GO:0004075]; DNA binding domain binding [GO:0050692]; metal ion binding [GO:0046872]; nuclear thyroid hormone receptor binding [GO:0046966]; signaling receptor binding [GO:0005102]; sterol response element binding [GO:0032810]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0003989; GO:0004075; GO:0005102; GO:0005524; GO:0005737; GO:0005739; GO:0006633; GO:0009374; GO:0009743; GO:0010628; GO:0032810; GO:0040029; GO:0045893; GO:0046872; GO:0046966; GO:0050692; GO:0070542; GO:0097066; GO:2001295
GN014709	GN014709.1	Q9P2C4	54.8	480	529	475	7.39e-180	517	TM181_HUMAN	Transmembrane protein 181	Homo sapiens (Human)		toxic substance binding [GO:0015643]	membrane [GO:0016020]	GO:0015643; GO:0016020
GN014711	GN014711.1	A0A345BJN8	29.6	186	431	919	5.82e-21	99.4	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN014714	GN014714.1	P32629	29.9	201	261	500	5.11e-21	95.1	ANP1_YEAST	Mannan polymerase II complex ANP1 subunit (M-Pol II subunit ANP1) (Aminonitrophenyl propanediol resistance protein)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	cell wall mannoprotein biosynthetic process [GO:0000032]; protein N-linked glycosylation [GO:0006487]	alpha-1,6-mannosyltransferase activity [GO:0000009]	endoplasmic reticulum membrane [GO:0005789]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; mannan polymerase complex [GO:0000136]	GO:0000009; GO:0000032; GO:0000136; GO:0000137; GO:0000139; GO:0005789; GO:0006487
GN014715	GN014715.1	P70490	37.3	177	329	427	5.07e-23	102	MFGM_RAT	Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (O-acetyl GD3 ganglioside synthase) (AGS) (SED1)	Rattus norvegicus (Rat)	apoptotic cell clearance [GO:0043277]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of phagocytosis [GO:0050766]; response to estrogen [GO:0043627]	integrin binding [GO:0005178]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylserine binding [GO:0001786]	acrosomal membrane [GO:0002080]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0001786; GO:0002080; GO:0005178; GO:0005576; GO:0006910; GO:0006911; GO:0008284; GO:0008429; GO:0009897; GO:0016020; GO:0043277; GO:0043627; GO:0050766
GN014716	GN014716.1	Q6ZXV5	51.8	812	841	915	4.35e-279	798	TMTC3_HUMAN	Protein O-mannosyl-transferase TMTC3 (EC 2.4.1.109) (Protein SMILE) (Transmembrane O-mannosyltransferase targeting cadherins 3) (Transmembrane and tetratricopeptide repeat-containing 3)	Homo sapiens (Human)	positive regulation of proteasomal protein catabolic process [GO:1901800]; protein O-linked glycosylation via mannose [GO:0035269]; response to endoplasmic reticulum stress [GO:0034976]	dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	GO:0000030; GO:0004169; GO:0005783; GO:0016020; GO:0034976; GO:0035269; GO:1901800
GN014717	GN014717.1	Q6XD76	58.9	73	274	172	3.62e-20	88.2	ASCL4_HUMAN	Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44)	Homo sapiens (Human)	epithelium development [GO:0060429]; regulation of transcription by RNA polymerase II [GO:0006357]; skin development [GO:0043588]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	chromatin [GO:0000785]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000785; GO:0000977; GO:0000981; GO:0001227; GO:0006357; GO:0043588; GO:0046983; GO:0060429; GO:0090575
GN014718	GN014718.1	Q2M2T3	69.4	49	110	181	8.79e-16	72.0	MPCX_BOVIN	Mitochondrial pyruvate carrier-like protein (Brain protein 44-like protein 2)	Bos taurus (Bovine)	pyruvate import into mitochondria [GO:0006850]	pyruvate transmembrane transporter activity [GO:0050833]	mitochondrial inner membrane [GO:0005743]	GO:0005743; GO:0006850; GO:0050833
GN014719	GN014719.1	Q8HXM1	42.2	564	419	572	1.68e-90	287	CSTF2_BOVIN	Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64)	Bos taurus (Bovine)	mRNA 3'-end processing [GO:0031124]	RNA binding [GO:0003723]	cleavage body [GO:0071920]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005847; GO:0031124; GO:0071920
GN014720	GN014720.1	Q9UMY4	73.5	155	165	162	7.41e-84	246	SNX12_HUMAN	Sorting nexin-12	Homo sapiens (Human)	endocytic recycling [GO:0032456]; late endosome to Golgi transport [GO:0034499]; negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of protein transport [GO:0051224]; regulation of endocytosis [GO:0030100]	enzyme binding [GO:0019899]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; retromer complex [GO:0030904]	GO:0005769; GO:0010629; GO:0010955; GO:0019899; GO:0030100; GO:0030904; GO:0031901; GO:0032266; GO:0032456; GO:0034499; GO:0035091; GO:0042177; GO:0051224; GO:2000642
GN014721	GN014721.1	P52900	64.4	357	388	363	1.01e-162	463	ODPA_SMIMA	Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (PDHE1-A) (EC 1.2.4.1)	Sminthopsis macroura (Stripe-faced dunnart)	pyruvate decarboxylation to acetyl-CoA [GO:0006086]	pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]	mitochondrial matrix [GO:0005759]; pyruvate dehydrogenase complex [GO:0045254]	GO:0004739; GO:0005759; GO:0006086; GO:0045254
GN014723	GN014723.1	Q8NBX0	38.3	133	138	429	5.12e-21	90.5	SCPDL_HUMAN	Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-)	Homo sapiens (Human)	glycolipid biosynthetic process [GO:0009247]		extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]	GO:0005576; GO:0005634; GO:0005739; GO:0005811; GO:0009247; GO:0016020; GO:0030496; GO:0031093
GN014724	GN014724.1	Q94KD8	35.5	702	773	768	1.40e-108	352	BXL2_ARATH	Probable beta-D-xylosidase 2 (AtBXL2) (EC 3.2.1.-)	Arabidopsis thaliana (Mouse-ear cress)	xylan catabolic process [GO:0045493]	xylan 1,4-beta-xylosidase activity [GO:0009044]	extracellular region [GO:0005576]	GO:0005576; GO:0009044; GO:0045493
GN014725	GN014725.1	Q9VCA2	35.9	465	485	548	6.91e-94	298	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN014727	GN014727.1	Q7KVW5	49.6	419	453	927	9.72e-122	379	KCNN_DROME	Small conductance calcium-activated potassium channel protein (Protein SK) (dSK)	Drosophila melanogaster (Fruit fly)	potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential in photoreceptor cell [GO:0016057]	calmodulin binding [GO:0005516]; photoreceptor activity [GO:0009881]; small conductance calcium-activated potassium channel activity [GO:0016286]	membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	GO:0005516; GO:0005886; GO:0006813; GO:0009881; GO:0016020; GO:0016057; GO:0016286; GO:0043005; GO:0043025; GO:0071805
GN014731	GN014731.1	A6QLI8	39.7	441	408	438	5.85e-95	294	T2EA_BOVIN	General transcription factor IIE subunit 1 (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha)	Bos taurus (Bovine)	transcription initiation at RNA polymerase II promoter [GO:0006367]		nucleus [GO:0005634]; transcription factor TFIIE complex [GO:0005673]	GO:0005634; GO:0005673; GO:0006367
GN014735	GN014735.1	Q7Z0T3	44.7	103	124	125	1.38e-22	88.6	TEMPT_APLCA	Temptin	Aplysia californica (California sea hare)			extracellular region [GO:0005576]	GO:0005576
GN014736	GN014736.1	Q7Z0T3	48.7	113	116	125	8.58e-27	99.0	TEMPT_APLCA	Temptin	Aplysia californica (California sea hare)			extracellular region [GO:0005576]	GO:0005576
GN014738	GN014738.1	Q19673	35.8	307	833	693	5.49e-51	194	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN014739	GN014739.1	Q8ITC7	37.2	234	286	477	4.92e-39	145	CAPAR_DROME	Neuropeptides capa receptor (Cap2b receptor) (Capability receptor)	Drosophila melanogaster (Fruit fly)	body fluid secretion [GO:0007589]; cellular response to desiccation [GO:0071465]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of calcium ion transport [GO:0051928]	neuromedin U receptor activity [GO:0001607]; neuropeptide receptor activity [GO:0008188]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001607; GO:0005886; GO:0007186; GO:0007218; GO:0007589; GO:0008188; GO:0016020; GO:0016323; GO:0051928; GO:0071465
GN014740	GN014740.1	Q9JLB4	25.8	654	864	3623	4.49e-44	177	CUBN_MOUSE	Cubilin (Intrinsic factor-cobalamin receptor)	Mus musculus (Mouse)	cobalamin catabolic process [GO:0042366]; cobalamin transport [GO:0015889]; endocytic hemoglobin import into cell [GO:0020028]; in utero embryonic development [GO:0001701]; lipoprotein transport [GO:0042953]; receptor-mediated endocytosis [GO:0006898]; response to bacterium [GO:0009617]; response to nutrient [GO:0007584]	calcium ion binding [GO:0005509]; cargo receptor activity [GO:0038024]; hemoglobin binding [GO:0030492]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; signaling receptor activity [GO:0038023]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; brush border [GO:0005903]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; coated vesicle [GO:0030135]; cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; signaling receptor complex [GO:0043235]	GO:0001701; GO:0005509; GO:0005737; GO:0005765; GO:0005768; GO:0005783; GO:0005794; GO:0005798; GO:0005886; GO:0005903; GO:0005905; GO:0006898; GO:0007584; GO:0009617; GO:0010008; GO:0015889; GO:0016020; GO:0016324; GO:0020028; GO:0030135; GO:0030139; GO:0030492; GO:0030666; GO:0031526; GO:0031528; GO:0032991; GO:0038023; GO:0038024; GO:0042366; GO:0042802; GO:0042803; GO:0042953; GO:0043202; GO:0043235; GO:0045177; GO:0070062
GN014744	GN014744.1	Q8BH60	63.6	374	459	463	3.57e-154	448	GOPC_MOUSE	Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (PDZ protein interacting specifically with TC10) (PIST)	Mus musculus (Mouse)	autophagy [GO:0006914]; gene expression [GO:0010467]; negative regulation of anion channel activity [GO:0010360]; negative regulation of protein localization to cell surface [GO:2000009]; spermatid nucleus differentiation [GO:0007289]	frizzled binding [GO:0005109]; GTPase regulator activity [GO:0030695]; identical protein binding [GO:0042802]; molecular sequestering activity [GO:0140313]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; trans-Golgi network transport vesicle [GO:0030140]	GO:0000139; GO:0005109; GO:0005737; GO:0005794; GO:0005886; GO:0006914; GO:0007289; GO:0010360; GO:0010467; GO:0014069; GO:0016020; GO:0019905; GO:0030140; GO:0030165; GO:0030425; GO:0030695; GO:0032991; GO:0042802; GO:0042803; GO:0044325; GO:0045202; GO:0140313; GO:2000009
GN014750	GN014750.1	Q92738	55.9	381	690	828	1.55e-138	429	US6NL_HUMAN	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre)	Homo sapiens (Human)	Golgi organization [GO:0007030]; plasma membrane to endosome transport [GO:0048227]; positive regulation of GTPase activity [GO:0043547]; regulation of Golgi organization [GO:1903358]; retrograde transport, plasma membrane to Golgi [GO:0035526]; virion assembly [GO:0019068]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	GO:0005096; GO:0005829; GO:0005886; GO:0007030; GO:0019068; GO:0031267; GO:0031410; GO:0032588; GO:0035526; GO:0043547; GO:0048227; GO:1903358
GN014756	GN014756.1	Q16533	37.0	284	446	368	1.38e-47	170	SNPC1_HUMAN	snRNA-activating protein complex subunit 1 (SNAPc subunit 1) (Proximal sequence element-binding transcription factor subunit gamma) (PSE-binding factor subunit gamma) (PTF subunit gamma) (Small nuclear RNA-activating complex polypeptide 1) (snRNA-activating protein complex 43 kDa subunit) (SNAPc 43 kDa subunit)	Homo sapiens (Human)	snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]	RNA polymerase II general transcription initiation factor activity [GO:0016251]; RNA polymerase III general transcription initiation factor activity [GO:0000995]; sequence-specific DNA binding [GO:0043565]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; snRNA-activating protein complex [GO:0019185]	GO:0000995; GO:0005654; GO:0005730; GO:0016251; GO:0019185; GO:0042795; GO:0042796; GO:0043565
GN014759	GN014759.1	A2BE28	24.6	403	534	776	8.44e-25	112	LAS1L_MOUSE	Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog)	Mus musculus (Mouse)	maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]; rRNA processing [GO:0006364]	endonuclease activity [GO:0004519]	cytoplasm [GO:0005737]; Las1 complex [GO:0090730]; MLL1 complex [GO:0071339]; nucleolus [GO:0005730]; nucleus [GO:0005634]; rixosome complex [GO:0120330]	GO:0000460; GO:0000470; GO:0004519; GO:0005634; GO:0005730; GO:0005737; GO:0006364; GO:0071339; GO:0090730; GO:0120330
GN014760	GN014760.1	Q9TT23	29.7	269	301	325	9.13e-19	88.2	MC5R_PANTR	Melanocortin receptor 5 (MC5-R)	Pan troglodytes (Chimpanzee)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; negative regulation of immune response [GO:0050777]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; temperature homeostasis [GO:0001659]	corticotropin receptor activity [GO:0004978]; melanocortin receptor activity [GO:0004977]; melanocyte-stimulating hormone receptor activity [GO:0004980]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0001659; GO:0004977; GO:0004978; GO:0004980; GO:0005737; GO:0005886; GO:0007189; GO:0045921; GO:0050777; GO:0070374
GN014765	GN014765.1	Q2KJC1	66.8	805	796	802	0.0	963	CDC5L_BOVIN	Cell division cycle 5-like protein (Cdc5-like protein)	Bos taurus (Bovine)	DNA damage checkpoint signaling [GO:0000077]; mRNA splicing, via spliceosome [GO:0000398]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; WD40-repeat domain binding [GO:0071987]	cytoplasm [GO:0005737]; DNA replication factor A complex [GO:0005662]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U12-type catalytic step 2 spliceosome [GO:0071018]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000077; GO:0000398; GO:0000974; GO:0000977; GO:0000981; GO:0001228; GO:0005634; GO:0005662; GO:0005681; GO:0005737; GO:0006357; GO:0016607; GO:0042802; GO:0071006; GO:0071007; GO:0071014; GO:0071018; GO:0071020; GO:0071987
GN014766	GN014766.1	Q18297	25.3	261	940	1211	2.13e-09	65.5	TRPA1_CAEEL	Transient receptor potential cation channel subfamily A member 1 homolog	Caenorhabditis elegans		monoatomic ion channel activity [GO:0005216]	neuronal cell body [GO:0043025]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]	GO:0005216; GO:0005886; GO:0043025; GO:0097730
GN014767	GN014767.1	Q5VYY1	32.0	122	1382	191	7.64e-09	60.5	ANR22_HUMAN	Ankyrin repeat domain-containing protein 22	Homo sapiens (Human)	immune response [GO:0006955]; leukocyte migration [GO:0050900]; response to wounding [GO:0009611]			GO:0006955; GO:0009611; GO:0050900
GN014769	GN014769.1	Q9Z2F6	31.0	174	244	448	5.63e-09	59.3	BCL3_MOUSE	B-cell lymphoma 3 protein homolog (BCL-3)	Mus musculus (Mouse)	antimicrobial humoral response [GO:0019730]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of type II interferon production [GO:0032729]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to UV-C [GO:0010225]; response to virus [GO:0009615]; spleen development [GO:0048536]; T-helper 1 type immune response [GO:0042088]; T-helper 2 cell differentiation [GO:0045064]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	Bcl3-Bcl10 complex [GO:0032996]; Bcl3/NF-kappaB2 complex [GO:0033257]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	GO:0002268; GO:0002315; GO:0002455; GO:0002467; GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006606; GO:0006974; GO:0007249; GO:0009615; GO:0010225; GO:0019730; GO:0030198; GO:0030330; GO:0030496; GO:0030674; GO:0032717; GO:0032720; GO:0032729; GO:0032733; GO:0032991; GO:0032996; GO:0033257; GO:0036064; GO:0042088; GO:0042742; GO:0042771; GO:0042826; GO:0042832; GO:0042981; GO:0043066; GO:0045064; GO:0045727; GO:0045892; GO:0045893; GO:0045944; GO:0046426; GO:0048471; GO:0048536; GO:0140297; GO:1901222; GO:1901223
GN014771	GN014771.1	Q9CQM6	32.6	181	326	421	9.63e-12	68.9	ANR61_MOUSE	Ankyrin repeat domain-containing protein 61	Mus musculus (Mouse)			nucleoplasm [GO:0005654]	GO:0005654
GN014772	GN014772.1	P11533	31.5	1463	1641	3660	5.49e-198	659	DMD_CHICK	Dystrophin	Gallus gallus (Chicken)	muscle cell development [GO:0055001]; neuron development [GO:0048666]; regulation of muscle system process [GO:0090257]; skeletal muscle tissue development [GO:0007519]; synaptic signaling [GO:0099536]	zinc ion binding [GO:0008270]	cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; myofibril [GO:0030016]; plasma membrane bounded cell projection [GO:0120025]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]	GO:0005856; GO:0007519; GO:0008270; GO:0016010; GO:0030016; GO:0042383; GO:0045211; GO:0048666; GO:0055001; GO:0090257; GO:0099536; GO:0120025
GN014777	GN014777.1	Q63HN8	28.4	320	322	5207	3.94e-35	139	RN213_HUMAN	E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213)	Homo sapiens (Human)	angiogenesis [GO:0001525]; defense response to bacterium [GO:0042742]; lipid droplet formation [GO:0140042]; lipid ubiquitination [GO:0120323]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of lipid metabolic process [GO:0019216]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511]; xenophagy [GO:0098792]	ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]	GO:0001525; GO:0002040; GO:0004842; GO:0005737; GO:0005811; GO:0005829; GO:0006511; GO:0016020; GO:0016567; GO:0016887; GO:0019216; GO:0042742; GO:0046872; GO:0051865; GO:0061630; GO:0070534; GO:0098792; GO:0120323; GO:0140042; GO:2000051
GN014778	GN014778.1	E9Q555	25.4	768	764	5148	1.08e-57	218	RN213_MOUSE	E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213)	Mus musculus (Mouse)	angiogenesis [GO:0001525]; defense response to bacterium [GO:0042742]; lipid droplet formation [GO:0140042]; lipid ubiquitination [GO:0120323]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of lipid metabolic process [GO:0019216]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511]; xenophagy [GO:0098792]	ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; nucleolus [GO:0005730]	GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005811; GO:0005829; GO:0006511; GO:0016567; GO:0016887; GO:0019216; GO:0042742; GO:0046872; GO:0051865; GO:0061630; GO:0070534; GO:0098792; GO:0120323; GO:0140042; GO:2000051
GN014779	GN014779.1	A0A0R4IBK5	39.0	1265	1374	5209	3.17e-252	809	R213A_DANRE	E3 ubiquitin-protein ligase rnf213-alpha (EC 2.3.2.27) (EC 3.6.4.-) (E3 ubiquitin-lipopolysaccharide ligase rnf213-alpha) (EC 2.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha)	Danio rerio (Zebrafish) (Brachydanio rerio)	blood circulation [GO:0008015]; defense response to bacterium [GO:0042742]; lipid droplet formation [GO:0140042]; lipid ubiquitination [GO:0120323]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein K63-linked ubiquitination [GO:0070534]; regulation of angiogenesis [GO:0045765]; regulation of lipid metabolic process [GO:0019216]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511]; xenophagy [GO:0098792]	ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; lipid droplet [GO:0005811]	GO:0002040; GO:0004842; GO:0005811; GO:0005829; GO:0006511; GO:0008015; GO:0016887; GO:0019216; GO:0042742; GO:0045765; GO:0046872; GO:0061630; GO:0070534; GO:0098792; GO:0120323; GO:0140042; GO:2000051
GN014780	GN014780.1	A0A0R4IBK5	37.3	1393	1388	5209	3.28e-257	824	R213A_DANRE	E3 ubiquitin-protein ligase rnf213-alpha (EC 2.3.2.27) (EC 3.6.4.-) (E3 ubiquitin-lipopolysaccharide ligase rnf213-alpha) (EC 2.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha)	Danio rerio (Zebrafish) (Brachydanio rerio)	blood circulation [GO:0008015]; defense response to bacterium [GO:0042742]; lipid droplet formation [GO:0140042]; lipid ubiquitination [GO:0120323]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein K63-linked ubiquitination [GO:0070534]; regulation of angiogenesis [GO:0045765]; regulation of lipid metabolic process [GO:0019216]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511]; xenophagy [GO:0098792]	ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; lipid droplet [GO:0005811]	GO:0002040; GO:0004842; GO:0005811; GO:0005829; GO:0006511; GO:0008015; GO:0016887; GO:0019216; GO:0042742; GO:0045765; GO:0046872; GO:0061630; GO:0070534; GO:0098792; GO:0120323; GO:0140042; GO:2000051
GN014781	GN014781.1	Q8BHY3	43.8	840	989	960	3.25e-217	647	ANO1_MOUSE	Anoctamin-1 (Transmembrane protein 16A)	Mus musculus (Mouse)	cellular response to heat [GO:0034605]; cellular response to peptide [GO:1901653]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; glial cell projection elongation [GO:0106091]; iodide transport [GO:0015705]; mucus secretion [GO:0070254]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; protein localization to membrane [GO:0072657]; regulation of membrane potential [GO:0042391]; trachea development [GO:0060438]	calcium-activated cation channel activity [GO:0005227]; chloride channel activity [GO:0005254]; identical protein binding [GO:0042802]; intracellularly calcium-gated chloride channel activity [GO:0005229]; iodide transmembrane transporter activity [GO:0015111]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; voltage-gated chloride channel activity [GO:0005247]	apical plasma membrane [GO:0016324]; external side of plasma membrane [GO:0009897]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]	GO:0005102; GO:0005227; GO:0005229; GO:0005247; GO:0005254; GO:0005654; GO:0005886; GO:0006821; GO:0007200; GO:0009897; GO:0015111; GO:0015705; GO:0016324; GO:0034605; GO:0042391; GO:0042734; GO:0042802; GO:0042803; GO:0050965; GO:0060438; GO:0070254; GO:0072657; GO:0098793; GO:0098978; GO:0106091; GO:1901653; GO:1902476
GN014783	GN014783.1	Q6NS09	36.8	258	292	280	2.02e-45	157	TM45B_XENLA	Transmembrane protein 45B	Xenopus laevis (African clawed frog)	response to pain [GO:0048265]		endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; trans-Golgi network [GO:0005802]	GO:0005765; GO:0005802; GO:0010008; GO:0048265
GN014788	GN014788.1	Q8C790	59.1	279	323	301	2.11e-118	346	F221A_MOUSE	Protein FAM221A	Mus musculus (Mouse)				
GN014789	GN014789.1	Q9QX47	43.5	421	1082	2444	4.90e-75	276	SON_MOUSE	Protein SON (Negative regulatory element-binding protein) (NRE-binding protein)	Mus musculus (Mouse)	microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; regulation of cell cycle [GO:0051726]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]	RNA binding [GO:0003723]; RS domain binding [GO:0050733]	nuclear speck [GO:0016607]	GO:0000226; GO:0000281; GO:0003723; GO:0006397; GO:0016607; GO:0043066; GO:0043484; GO:0048024; GO:0050733; GO:0051726
GN014794	GN014794.1	Q6DFS6	71.7	219	222	220	5.66e-95	279	CHM2A_XENTR	Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	exit from mitosis [GO:0010458]; late endosome to vacuole transport [GO:0045324]; nuclear membrane reassembly [GO:0031468]		ESCRT III complex [GO:0000815]; late endosome membrane [GO:0031902]; nuclear envelope [GO:0005635]	GO:0000815; GO:0005635; GO:0010458; GO:0031468; GO:0031902; GO:0045324
GN014795	GN014795.1	O75534	46.3	780	813	798	1.40e-226	659	CSDE1_HUMAN	Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR)	Homo sapiens (Human)	CRD-mediated mRNA stabilization [GO:0070934]; IRES-dependent viral translational initiation [GO:0075522]; male gonad development [GO:0008584]; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900152]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of translation [GO:0045727]; regulation of translational initiation [GO:0006446]; stress granule assembly [GO:0034063]	lncRNA binding [GO:0106222]; mRNA binding [GO:0003729]; protein-RNA adaptor activity [GO:0140517]; RISC complex binding [GO:1905172]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]	CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mCRD-mediated mRNA stability complex [GO:0106002]; P-body [GO:0000932]	GO:0000932; GO:0003723; GO:0003729; GO:0005829; GO:0006446; GO:0008584; GO:0010494; GO:0034063; GO:0035613; GO:0045727; GO:0070934; GO:0070937; GO:0070966; GO:0075522; GO:0106002; GO:0106222; GO:0140517; GO:1900152; GO:1905172; GO:2000767
GN014796	GN014796.1	O60678	48.4	461	539	531	1.45e-138	414	ANM3_HUMAN	Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3)	Homo sapiens (Human)	negative regulation of protein ubiquitination [GO:0031397]; negative regulation of retinoic acid biosynthetic process [GO:1900053]; positive regulation of osteoblast differentiation [GO:0045669]; protein methylation [GO:0006479]; transcription initiation-coupled chromatin remodeling [GO:0045815]	histone H4R3 methyltransferase activity [GO:0044020]; methyltransferase activity [GO:0008168]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005829; GO:0006479; GO:0008168; GO:0016274; GO:0031397; GO:0035241; GO:0035242; GO:0044020; GO:0045669; GO:0045815; GO:1900053
GN014798	GN014798.1	Q80T23	51.4	346	1585	753	2.96e-104	354	SYTL5_MOUSE	Synaptotagmin-like protein 5	Mus musculus (Mouse)	exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]	neurexin family protein binding [GO:0042043]; phospholipid binding [GO:0005543]; small GTPase binding [GO:0031267]	exocytic vesicle [GO:0070382]; plasma membrane [GO:0005886]	GO:0005543; GO:0005886; GO:0006886; GO:0006887; GO:0031267; GO:0042043; GO:0070382
GN014799	GN014799.1	A5YVV0	28.5	586	702	661	1.87e-50	190	LAC3_ANOGA	Multicopper oxidase 3 (AgMCO3) (EC 1.10.3.2) (Laccase-3)	Anopheles gambiae (African malaria mosquito)		copper ion binding [GO:0005507]; hydroquinone:oxygen oxidoreductase activity [GO:0052716]	extracellular region [GO:0005576]	GO:0005507; GO:0005576; GO:0052716
GN014800	GN014800.1	A5YVV0	28.2	585	640	661	5.54e-48	182	LAC3_ANOGA	Multicopper oxidase 3 (AgMCO3) (EC 1.10.3.2) (Laccase-3)	Anopheles gambiae (African malaria mosquito)		copper ion binding [GO:0005507]; hydroquinone:oxygen oxidoreductase activity [GO:0052716]	extracellular region [GO:0005576]	GO:0005507; GO:0005576; GO:0052716
GN014807	GN014807.1	E1C1R4	48.7	1387	1364	1375	0.0	1191	UBP47_CHICK	Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47)	Gallus gallus (Chicken)	base-excision repair [GO:0006284]; DNA damage response [GO:0006974]; monoubiquitinated protein deubiquitination [GO:0035520]	cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]	GO:0004843; GO:0005737; GO:0006284; GO:0006974; GO:0035520
GN014808	GN014808.1	Q2TBP7	67.9	81	102	103	2.27e-33	114	MYCBP_BOVIN	c-Myc-binding protein (Associate of Myc 1) (AMY-1)	Bos taurus (Bovine)	regulation of DNA-templated transcription [GO:0006355]	transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005737; GO:0006355
GN014811	GN014811.1	Q9DFQ7	66.7	117	115	157	3.33e-35	121	RL24_GILMI	Large ribosomal subunit protein eL24 (60S ribosomal protein L24)	Gillichthys mirabilis (Long-jawed mudsucker)	cytoplasmic translation [GO:0002181]	mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]	GO:0002181; GO:0003729; GO:0003735; GO:0005737; GO:0022625
GN014813	GN014813.1	Q7JK24	31.7	243	263	326	4.07e-40	144	B3GT1_GORGO	Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)	Gorilla gorilla gorilla (Western lowland gorilla)	glucosylceramide metabolic process [GO:0006678]; glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006678; GO:0008499; GO:0009101; GO:0009312
GN014814	GN014814.1	Q5XJP0	39.2	176	225	382	3.22e-29	115	B3G5B_DANRE	Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase B (EC 2.4.1.206) (Lactotriaosylceramide synthase B) (Lc(3)Cer synthase B) (Lc3 synthase B) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5B) (BGnT-5B) (Beta-1,3-Gn-T5B) (Beta-1,3-N-acetylglucosaminyltransferase 5B) (Beta3Gn-T5B)	Danio rerio (Zebrafish) (Brachydanio rerio)	glycoprotein biosynthetic process [GO:0009101]; sphingolipid biosynthetic process [GO:0030148]	lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity [GO:0047256]	Golgi membrane [GO:0000139]	GO:0000139; GO:0009101; GO:0030148; GO:0047256
GN014817	GN014817.1	Q7JK24	31.4	255	337	326	2.10e-40	147	B3GT1_GORGO	Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)	Gorilla gorilla gorilla (Western lowland gorilla)	glucosylceramide metabolic process [GO:0006678]; glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006678; GO:0008499; GO:0009101; GO:0009312
GN014820	GN014820.1	P86854	35.6	104	198	156	1.84e-13	68.2	PLCL_MYTGA	Perlucin-like protein	Mytilus galloprovincialis (Mediterranean mussel)			extracellular region [GO:0005576]	GO:0005576
GN014824	GN014824.1	V5NAL9	34.2	114	131	899	1.36e-12	66.6	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN014826	GN014826.1	Q9HBY0	58.4	339	347	568	1.82e-146	428	NOX3_HUMAN	NADPH oxidase 3 (EC 1.6.3.-) (Mitogenic oxidase 2) (MOX-2) (gp91phox homolog 3) (GP91-3)	Homo sapiens (Human)	defense response [GO:0006952]; superoxide anion generation [GO:0042554]	heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activity [GO:0106292]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0006952; GO:0016174; GO:0016175; GO:0020037; GO:0042554; GO:0043020; GO:0070062; GO:0106292
GN014827	GN014827.1	Q8QZX5	40.9	93	147	122	7.03e-20	82.4	LSM10_MOUSE	U7 snRNA-associated Sm-like protein LSm10	Mus musculus (Mouse)	mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	histone pre-mRNA DCP binding [GO:0071208]; snRNA binding [GO:0017069]; U7 snRNA binding [GO:0071209]	Cajal body [GO:0015030]; cytoplasmic U snRNP body [GO:0071254]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; U7 snRNP [GO:0005683]	GO:0005654; GO:0005683; GO:0006398; GO:0015030; GO:0016604; GO:0017069; GO:0071208; GO:0071209; GO:0071254; GO:1900087
GN014828	GN014828.1	A6QQ68	27.6	243	449	264	1.67e-19	91.3	F228B_BOVIN	Protein FAM228B	Bos taurus (Bovine)				
GN014829	GN014829.1	Q9ULV1	59.5	469	509	537	1.51e-194	556	FZD4_HUMAN	Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344)	Homo sapiens (Human)	canonical Wnt signaling pathway [GO:0060070]; cellular response to retinoic acid [GO:0071300]; cerebellum vasculature morphogenesis [GO:0061301]; extracellular matrix-cell signaling [GO:0035426]; negative regulation of cell-substrate adhesion [GO:0010812]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; Norrin signaling pathway [GO:0110135]; positive regulation of cell migration [GO:0030335]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of transcription by RNA polymerase II [GO:0045944]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal blood vessel morphogenesis [GO:0061304]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]	amyloid-beta binding [GO:0001540]; cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; PDZ domain binding [GO:0030165]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	cell surface [GO:0009986]; cell-cell junction [GO:0005911]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]	GO:0001540; GO:0004896; GO:0005886; GO:0005911; GO:0007223; GO:0009986; GO:0010812; GO:0016055; GO:0017147; GO:0019955; GO:0030165; GO:0030182; GO:0030335; GO:0030425; GO:0030669; GO:0031625; GO:0035426; GO:0035567; GO:0038023; GO:0042803; GO:0042813; GO:0044877; GO:0045893; GO:0045944; GO:0046982; GO:0050775; GO:0060070; GO:0061299; GO:0061301; GO:0061304; GO:0071300; GO:0098978; GO:0110135; GO:0150012
GN014837	GN014837.1	Q9W0K0	49.8	223	559	490	5.67e-66	225	JIP1_DROME	JNK-interacting protein 1 (JIP-1) (APP-like-interacting protein 1) (APLIP1) (Protein eye developmental SP512)	Drosophila melanogaster (Fruit fly)	anterograde synaptic vesicle transport [GO:0048490]; axonal transport of mitochondrion [GO:0019896]; JNK cascade [GO:0007254]; regulation of JNK cascade [GO:0046328]; regulation of terminal button organization [GO:2000331]; retrograde synaptic vesicle transport [GO:0048491]	identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; MAP kinase scaffold activity [GO:0005078]; protein kinase binding [GO:0019901]	axon [GO:0030424]; axon cytoplasm [GO:1904115]	GO:0005078; GO:0007254; GO:0019894; GO:0019896; GO:0019901; GO:0030424; GO:0042802; GO:0046328; GO:0048490; GO:0048491; GO:1904115; GO:2000331
GN014850	GN014850.1	Q9JHI3	29.8	581	571	682	2.78e-70	242	SO2B1_RAT	Solute carrier organic anion transporter family member 2B1 (Organic anion transporter moatp1) (Organic anion transporting polypeptide 2B1) (OATP2B1) (Solute carrier family 21 member 9)	Rattus norvegicus (Rat)	cell population proliferation [GO:0008283]; cellular response to iron ion starvation [GO:0010106]; heme import into cell [GO:0140420]; intercellular transport [GO:0010496]; intracellular iron ion homeostasis [GO:0006879]; liver development [GO:0001889]; sodium-independent organic anion transport [GO:0043252]; transmembrane transport [GO:0055085]; xenobiotic transport [GO:0042908]	prostaglandin transmembrane transporter activity [GO:0015132]; secondary active transmembrane transporter activity [GO:0015291]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0001889; GO:0005886; GO:0006879; GO:0008283; GO:0009925; GO:0010106; GO:0010496; GO:0015132; GO:0015291; GO:0016323; GO:0016324; GO:0022857; GO:0042908; GO:0043252; GO:0055085; GO:0140420
GN014851	GN014851.1	Q9JHI3	30.6	671	684	682	4.64e-81	274	SO2B1_RAT	Solute carrier organic anion transporter family member 2B1 (Organic anion transporter moatp1) (Organic anion transporting polypeptide 2B1) (OATP2B1) (Solute carrier family 21 member 9)	Rattus norvegicus (Rat)	cell population proliferation [GO:0008283]; cellular response to iron ion starvation [GO:0010106]; heme import into cell [GO:0140420]; intercellular transport [GO:0010496]; intracellular iron ion homeostasis [GO:0006879]; liver development [GO:0001889]; sodium-independent organic anion transport [GO:0043252]; transmembrane transport [GO:0055085]; xenobiotic transport [GO:0042908]	prostaglandin transmembrane transporter activity [GO:0015132]; secondary active transmembrane transporter activity [GO:0015291]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0001889; GO:0005886; GO:0006879; GO:0008283; GO:0009925; GO:0010106; GO:0010496; GO:0015132; GO:0015291; GO:0016323; GO:0016324; GO:0022857; GO:0042908; GO:0043252; GO:0055085; GO:0140420
GN014859	GN014859.1	Q75J93	32.2	522	778	842	3.92e-65	236	CPAS1_DICDI	Circularly permutated Ras protein 1 (DdiCPRas1)	Dictyostelium discoideum (Social amoeba)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; small GTPase-mediated signal transduction [GO:0007264]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; zinc ion binding [GO:0008270]	COPII vesicle coat [GO:0030127]; plasma membrane [GO:0005886]	GO:0003924; GO:0005525; GO:0005886; GO:0006886; GO:0006888; GO:0007264; GO:0008270; GO:0030127
GN014860	GN014860.1	Q5FVR2	51.8	371	406	476	9.34e-120	359	TYPH_RAT	Thymidine phosphorylase (TP) (EC 2.4.2.4) (TdRPase)	Rattus norvegicus (Rat)	dTMP catabolic process [GO:0046074]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]	1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; protein homodimerization activity [GO:0042803]; thymidine phosphorylase activity [GO:0009032]	cytosol [GO:0005829]	GO:0004645; GO:0005829; GO:0006206; GO:0006213; GO:0009032; GO:0042803; GO:0046074
GN014861	GN014861.1	Q7Q5J5	36.9	141	145	290	6.78e-17	78.2	P47R_ANOGA	Pfs47 receptor (AgP47Rec) (P47Rec)	Anopheles gambiae (African malaria mosquito)			cytoplasm [GO:0005737]	GO:0005737
GN014862	GN014862.1	P83298	42.5	240	261	242	2.44e-56	183	FIBC_LUMRU	Fibrinolytic enzyme, isozyme C (F-II) (EC 3.4.21.-)	Lumbricus rubellus (Humus earthworm)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]		GO:0004252; GO:0006508
GN014863	GN014863.1	Q99N42	59.5	74	79	471	4.17e-20	85.5	TYPH_MOUSE	Thymidine phosphorylase (TP) (EC 2.4.2.4) (TdRPase)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; chemotaxis [GO:0006935]; dTMP catabolic process [GO:0046074]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]; regulation of gastric motility [GO:1905333]; regulation of myelination [GO:0031641]; regulation of transmission of nerve impulse [GO:0051969]	1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; protein homodimerization activity [GO:0042803]; thymidine phosphorylase activity [GO:0009032]	cytosol [GO:0005829]	GO:0004645; GO:0005829; GO:0006206; GO:0006213; GO:0006935; GO:0009032; GO:0009887; GO:0031641; GO:0042803; GO:0046074; GO:0051969; GO:1905333
GN014866	GN014866.1	P26356	32.9	173	169	233	9.27e-14	69.7	TBP1_WHEAT	TATA-box-binding protein 1 (TATA sequence-binding protein 1) (TBP-1) (TATA-binding factor 1) (TATA-box factor 1) (Transcription initiation factor TFIID TBP-1 subunit)	Triticum aestivum (Wheat)	DNA-templated transcription initiation [GO:0006352]	DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0006352; GO:0016251
GN014868	GN014868.1	P34456	25.3	170	179	419	2.95e-11	64.3	YMD2_CAEEL	Uncharacterized protein F54H12.2	Caenorhabditis elegans	deoxyribonucleotide biosynthetic process [GO:0009263]	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]	cytosol [GO:0005829]	GO:0004748; GO:0005829; GO:0009263
GN014869	GN014869.1	P83298	40.1	197	248	242	2.26e-41	144	FIBC_LUMRU	Fibrinolytic enzyme, isozyme C (F-II) (EC 3.4.21.-)	Lumbricus rubellus (Humus earthworm)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]		GO:0004252; GO:0006508
GN014870	GN014870.1	P83298	37.2	180	192	242	1.74e-33	122	FIBC_LUMRU	Fibrinolytic enzyme, isozyme C (F-II) (EC 3.4.21.-)	Lumbricus rubellus (Humus earthworm)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]		GO:0004252; GO:0006508
GN014877	GN014877.1	P35408	31.3	310	378	488	2.97e-36	140	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of stress fiber assembly [GO:0051492]; response to mechanical stimulus [GO:0009612]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0009612; GO:0016020; GO:0033624; GO:0034695; GO:0042093; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070371; GO:0071260; GO:0071380; GO:2000420
GN014878	GN014878.1	O75027	49.1	603	632	752	7.05e-196	572	ABCB7_HUMAN	Iron-sulfur clusters transporter ABCB7, mitochondrial (ATP-binding cassette sub-family B member 7, mitochondrial) (ATP-binding cassette transporter 7) (ABC transporter 7 protein)	Homo sapiens (Human)	heme biosynthetic process [GO:0006783]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; iron-sulfur cluster assembly [GO:0016226]; iron-sulfur cluster export from the mitochondrion [GO:0140466]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; positive regulation of heme biosynthetic process [GO:0070455]; positive regulation of iron-sulfur cluster assembly [GO:1903331]	ABC-type iron-sulfur cluster transporter activity [GO:0140481]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; heme transmembrane transporter activity [GO:0015232]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	ATP-binding cassette (ABC) transporter complex [GO:0043190]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	GO:0005524; GO:0005739; GO:0005743; GO:0006783; GO:0006879; GO:0015232; GO:0016226; GO:0016887; GO:0031966; GO:0034755; GO:0042626; GO:0042802; GO:0042803; GO:0043190; GO:0070455; GO:0140466; GO:0140481; GO:1903331; GO:1903427
GN014879	GN014879.1	Q6NYU7	70.0	203	224	257	1.08e-101	298	UPP_DANRE	Uracil phosphoribosyltransferase homolog	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN014880	GN014880.1	Q9QZP2	32.8	198	885	798	8.49e-19	95.5	PRDM4_RAT	PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4)	Rattus norvegicus (Rat)	cellular response to growth factor stimulus [GO:0071363]; cellular response to nutrient [GO:0031670]; negative regulation of cell growth [GO:0030308]; negative regulation of gene expression [GO:0010629]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of stem cell differentiation [GO:2000736]; transcription by RNA polymerase II [GO:0006366]	death receptor binding [GO:0005123]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone methyltransferase binding [GO:1990226]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0005123; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006366; GO:0010468; GO:0010629; GO:0030308; GO:0031670; GO:0035097; GO:0045944; GO:0071363; GO:1990226; GO:1990837; GO:2000177; GO:2000736
GN014881	GN014881.1	O61366	27.3	205	241	1302	4.87e-16	80.5	GPRS_DROME	Serine-enriched protein	Drosophila melanogaster (Fruit fly)				
GN014882	GN014882.1	Q8C419	35.7	112	902	1200	7.66e-11	70.1	MGLYR_MOUSE	Metabotropic glycine receptor (mGlyR) (G protein-coupled receptor 158)	Mus musculus (Mouse)	brain development [GO:0007420]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of neurotransmitter secretion [GO:0001956]; protein localization to plasma membrane [GO:0072659]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synapse organization [GO:0050807]	enzyme activator activity [GO:0008047]; G protein-coupled glycine receptor activity [GO:0160079]; transmembrane signaling receptor activity [GO:0004888]	membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	GO:0001956; GO:0004888; GO:0005634; GO:0005886; GO:0007186; GO:0007420; GO:0008047; GO:0008277; GO:0016020; GO:0042734; GO:0045211; GO:0045744; GO:0050807; GO:0050890; GO:0072659; GO:0098839; GO:0160079
GN014888	GN014888.1	Q90XB3	49.3	69	265	298	8.96e-15	75.9	OLIG2_CHICK	Oligodendrocyte transcription factor 2 (Oligo2)	Gallus gallus (Chicken)	axon development [GO:0061564]; myelination [GO:0042552]; oligodendrocyte cell fate specification [GO:0021778]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ development [GO:0007423]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; HMG box domain binding [GO:0071837]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000981; GO:0005634; GO:0005737; GO:0007423; GO:0021778; GO:0042552; GO:0042802; GO:0045944; GO:0046983; GO:0061564; GO:0070888; GO:0071837
GN014889	GN014889.1	Q60769	24.3	820	1014	775	7.43e-51	196	TNAP3_MOUSE	Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (Putative DNA-binding protein A20) (Zinc finger protein A20)	Mus musculus (Mouse)	B-1 B cell homeostasis [GO:0001922]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; establishment of protein localization to vacuole [GO:0072666]; marginal zone B cell differentiation [GO:0002315]; negative regulation of autophagy [GO:0010507]; negative regulation of B cell activation [GO:0050869]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of CD40 signaling pathway [GO:2000349]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of granuloma formation [GO:0002632]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070429]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of toll-like receptor 5 signaling pathway [GO:0034148]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of protein catabolic process [GO:0045732]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked deubiquitination [GO:0070536]; regulation of germinal center formation [GO:0002634]; regulation of immunoglobulin production [GO:0002637]; regulation of innate immune response [GO:0045088]; response to molecule of bacterial origin [GO:0002237]; response to muramyl dipeptide [GO:0032495]; response to wounding [GO:0009611]; tolerance induction to lipopolysaccharide [GO:0072573]	cysteine-type deubiquitinase activity [GO:0004843]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; K63-linked deubiquitinase activity [GO:0061578]; kinase binding [GO:0019900]; protease binding [GO:0002020]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; lysosome [GO:0005764]; nucleus [GO:0005634]	GO:0001922; GO:0002020; GO:0002237; GO:0002315; GO:0002632; GO:0002634; GO:0002637; GO:0002677; GO:0003677; GO:0004842; GO:0004843; GO:0005634; GO:0005737; GO:0005764; GO:0008270; GO:0009611; GO:0010507; GO:0016579; GO:0019900; GO:0031397; GO:0032495; GO:0032691; GO:0032703; GO:0032715; GO:0032720; GO:0034115; GO:0034140; GO:0034148; GO:0035871; GO:0042802; GO:0043124; GO:0043130; GO:0045088; GO:0045732; GO:0045824; GO:0048662; GO:0050728; GO:0050869; GO:0061578; GO:0070301; GO:0070429; GO:0070433; GO:0070536; GO:0070936; GO:0071108; GO:0071222; GO:0071947; GO:0072573; GO:0072666; GO:1902042; GO:2000347; GO:2000349; GO:2000352; GO:2001237
GN014890	GN014890.1	P70665	41.3	247	271	541	6.62e-58	196	SIAE_MOUSE	Sialate O-acetylesterase (SIAE) (EC 3.1.1.53) (Sialic acid-specific 9-O-acetylesterase) (Yolk sac protein 2) [Cleaved into: Sialate O-acetylesterase small subunit; Sialate O-acetylesterase large subunit]	Mus musculus (Mouse)	carbohydrate metabolic process [GO:0005975]; regulation of immune system process [GO:0002682]	sialate 9-O-acetylesterase activity [GO:0106330]; sialate O-acetylesterase activity [GO:0001681]	lysosome [GO:0005764]	GO:0001681; GO:0002682; GO:0005764; GO:0005975; GO:0106330
GN014891	GN014891.1	E2QUD0	60.0	465	763	526	7.52e-185	540	GATA_CANLF	Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 3.5.1.2) (Glutaminyl-tRNA synthase-like protein 1)	Canis lupus familiaris (Dog) (Canis familiaris)	glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543]	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [GO:0050567]	glutamyl-tRNA(Gln) amidotransferase complex [GO:0030956]; mitochondrion [GO:0005739]	GO:0005739; GO:0030956; GO:0032543; GO:0050567; GO:0070681
GN014892	GN014892.1	Q29593	66.3	320	322	337	2.09e-148	423	TALDO_PIG	Transaldolase (EC 2.2.1.2)	Sus scrofa (Pig)	carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]	identical protein binding [GO:0042802]; transaldolase activity [GO:0004801]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004801; GO:0005634; GO:0005737; GO:0005975; GO:0006098; GO:0009052; GO:0042802
GN014901	GN014901.1	Q2TBK2	34.2	196	272	268	1.18e-17	83.6	RM09_BOVIN	Large ribosomal subunit protein bL9m (39S ribosomal protein L9, mitochondrial) (L9mt) (MRP-L9)	Bos taurus (Bovine)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005762; GO:0006412
GN014902	GN014902.1	Q2TBH0	38.9	167	172	254	3.45e-29	110	CMA1A_BOVIN	Ciliary microtubule associated protein 1A (Outer dense fiber of sperm tails protein 3) (Outer dense fiber protein 3)	Bos taurus (Bovine)			cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; outer dense fiber [GO:0001520]	GO:0001520; GO:0005737; GO:0005856
GN014903	GN014903.1	Q6AZB8	28.8	278	375	349	1.26e-28	117	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN014904	GN014904.1	Q6ZV70	45.4	427	416	420	1.95e-99	305	LANC3_HUMAN	LanC-like protein 3	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; peptide modification [GO:0031179]			GO:0005975; GO:0031179
GN014905	GN014905.1	Q58EL2	34.2	114	141	160	5.39e-12	62.8	NACHO_DANRE	Novel acetylcholine receptor chaperone (Transmembrane protein 35A)	Danio rerio (Zebrafish) (Brachydanio rerio)	chaperone-mediated protein complex assembly [GO:0051131]; positive regulation of protein localization to cell surface [GO:2000010]	acetylcholine receptor regulator activity [GO:0030548]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; peroxisomal membrane [GO:0005778]	GO:0005778; GO:0005783; GO:0005789; GO:0030548; GO:0031410; GO:0051131; GO:2000010
GN014906	GN014906.1	Q569B9	41.1	270	482	305	7.12e-62	207	MFI_RAT	Protein MFI (Mitochondrial fission factor interactor) (Protein C11orf65 homolog)	Rattus norvegicus (Rat)	negative regulation of mitochondrial fission [GO:0090258]; negative regulation of protein localization to mitochondrion [GO:1903748]		cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]	GO:0005741; GO:0005829; GO:0090258; GO:1903748
GN014907	GN014907.1	O60293	29.3	406	1294	1989	3.85e-19	98.2	ZC3H1_HUMAN	Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2)	Homo sapiens (Human)	RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]		extracellular region [GO:0005576]; MTREC complex [GO:1990477]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005576; GO:0005634; GO:0005654; GO:0006396; GO:0006401; GO:1990477
GN014909	GN014909.1	O60287	27.0	1935	2197	2271	7.19e-172	587	NPA1P_HUMAN	Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog)	Homo sapiens (Human)	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]	RNA binding [GO:0003723]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]	GO:0000463; GO:0000466; GO:0001650; GO:0003723; GO:0005730
GN014911	GN014911.1	Q6DF27	70.0	90	108	199	2.71e-30	109	CHM1B_XENTR	Charged multivesicular body protein 1b (Chromatin-modifying protein 1b) (CHMP1b)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	late endosome to vacuole transport [GO:0045324]		cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; late endosome membrane [GO:0031902]	GO:0000815; GO:0005829; GO:0031902; GO:0045324
GN014912	GN014912.1	Q05831	69.5	95	269	203	9.12e-28	108	H1L_MYTTR	Sperm-specific protein PHI-2B/PHI-3 [Cleaved into: Sperm-specific protein PHI-2B (PL-II*) (Sperm-specific linker histone H1-like protein); Sperm-specific protein PHI-3 (PL-IV) (Protamine-like protein PHI-3)]	Mytilus trossulus (Blue mussel)	nucleosome assembly [GO:0006334]	DNA binding [GO:0003677]; structural constituent of chromatin [GO:0030527]	nucleosome [GO:0000786]; nucleus [GO:0005634]	GO:0000786; GO:0003677; GO:0005634; GO:0006334; GO:0030527
GN014913	GN014913.1	Q3ZBF0	66.3	694	913	706	0.0	966	NADE_BOVIN	Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase)	Bos taurus (Bovine)	'de novo' NAD+ biosynthetic process from L-tryptophan [GO:0034354]; NAD+ biosynthetic process [GO:0009435]	ATP binding [GO:0005524]; glutaminase activity [GO:0004359]; NAD+ synthase (glutamine-hydrolyzing) activity [GO:0003952]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0003952; GO:0004359; GO:0005524; GO:0005737; GO:0005829; GO:0009435; GO:0034354
GN014914	GN014914.1	Q08DA3	31.5	1053	1066	826	8.26e-115	377	UBP16_BOVIN	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16)	Bos taurus (Bovine)	mitotic nuclear division [GO:0140014]; monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ribosome biogenesis [GO:0090070]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homotetramerization [GO:0051289]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; histone H2A deubiquitinase activity [GO:0140950]; ribosomal small subunit binding [GO:0043024]; transcription coactivator activity [GO:0003713]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003713; GO:0004197; GO:0004843; GO:0005634; GO:0005737; GO:0006357; GO:0008270; GO:0035520; GO:0042393; GO:0043024; GO:0043130; GO:0045893; GO:0045944; GO:0051289; GO:0051726; GO:0090070; GO:0140014; GO:0140950
GN014915	GN014915.1	Q5M9G6	71.5	172	329	389	3.98e-84	262	SNIP1_RAT	Smad nuclear interacting protein 1	Rattus norvegicus (Rat)	miRNA processing [GO:0035196]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]	mRNA binding [GO:0003729]; transcription regulator inhibitor activity [GO:0140416]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type catalytic step 2 spliceosome [GO:0071018]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]	GO:0000398; GO:0003729; GO:0005634; GO:0005654; GO:0035196; GO:0043124; GO:0071005; GO:0071006; GO:0071018; GO:0140416
GN014916	GN014916.1	Q8K1P8	24.8	431	688	545	3.96e-29	125	MOT8_RAT	Monocarboxylate transporter 8 (MCT 8) (Solute carrier family 16 member 2)	Rattus norvegicus (Rat)	amino acid import across plasma membrane [GO:0089718]; amino acid metabolic process [GO:0006520]; hormone transport [GO:0009914]; negative regulation of neural precursor cell proliferation [GO:2000178]; thyroid hormone generation [GO:0006590]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327]; thyroid-stimulating hormone secretion [GO:0070460]; transport across blood-brain barrier [GO:0150104]	amino acid transmembrane transporter activity [GO:0015171]; identical protein binding [GO:0042802]; thyroid hormone transmembrane transporter activity [GO:0015349]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0005886; GO:0006520; GO:0006590; GO:0009914; GO:0015171; GO:0015349; GO:0016324; GO:0042403; GO:0042802; GO:0070327; GO:0070460; GO:0089718; GO:0150104; GO:2000178
GN014919	GN014919.1	P26153	29.7	293	396	470	8.98e-36	139	ACHB4_CHICK	Neuronal acetylcholine receptor subunit beta-4 (Neuronal acetylcholine receptor non-alpha-3 chain) (N-alpha 3)	Gallus gallus (Chicken)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0015464; GO:0022848; GO:0034220; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060
GN014922	GN014922.1	Q8AVJ1	37.2	207	364	400	3.80e-39	146	PRR5_XENLA	Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1)	Xenopus laevis (African clawed frog)	TORC2 signaling [GO:0038203]		TORC2 complex [GO:0031932]	GO:0031932; GO:0038203
GN014926	GN014926.1	P15145	29.7	354	362	963	1.55e-54	196	AMPN_PIG	Aminopeptidase N (AP-N) (pAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (gp130) (CD antigen CD13)	Sus scrofa (Pig)	angiotensin maturation [GO:0002003]; peptide catabolic process [GO:0043171]	alanyl aminopeptidase activity [GO:0016285]; metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]	GO:0002003; GO:0005886; GO:0008270; GO:0016285; GO:0043171; GO:0070006
GN014928	GN014928.1	P79171	39.0	544	678	967	2.75e-112	363	AMPN_FELCA	Aminopeptidase N (AP-N) (fAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13)	Felis catus (Cat) (Felis silvestris catus)	angiotensin maturation [GO:0002003]; peptide catabolic process [GO:0043171]	alanyl aminopeptidase activity [GO:0016285]; metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]	GO:0002003; GO:0005886; GO:0008270; GO:0016285; GO:0043171; GO:0070006
GN014929	GN014929.1	D3ZGQ5	41.0	652	1439	698	2.80e-138	444	NEK8_RAT	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8)	Rattus norvegicus (Rat)	animal organ morphogenesis [GO:0009887]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; regulation of hippo signaling [GO:0035330]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]; cytoplasm [GO:0005737]	GO:0004674; GO:0005524; GO:0005737; GO:0005813; GO:0005929; GO:0005930; GO:0007368; GO:0007507; GO:0009887; GO:0035330; GO:0097543; GO:0097546; GO:0106310
GN014930	GN014930.1	Q9D1H6	26.3	179	197	173	1.34e-12	66.2	NDUF4_MOUSE	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa homolog)	Mus musculus (Mouse)	defense response to virus [GO:0051607]; mitochondrial respiratory chain complex I assembly [GO:0032981]; NADH dehydrogenase complex assembly [GO:0010257]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell population proliferation [GO:0008284]		cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]	GO:0005739; GO:0005829; GO:0008284; GO:0010257; GO:0016020; GO:0031966; GO:0032981; GO:0043066; GO:0051607
GN014931	GN014931.1	P30051	71.8	376	392	426	1.08e-173	494	TEAD1_MOUSE	Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13)	Mus musculus (Mouse)	cellular response to retinoic acid [GO:0071300]; embryonic heart tube morphogenesis [GO:0003143]; embryonic organ development [GO:0048568]; heart development [GO:0007507]; hippo signaling [GO:0035329]; lateral mesoderm development [GO:0048368]; notochord development [GO:0030903]; paraxial mesoderm development [GO:0048339]; positive regulation of cell growth [GO:0030307]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; transition between fast and slow fiber [GO:0014883]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TEAD-YAP complex [GO:0140552]; transcription regulator complex [GO:0005667]	GO:0000978; GO:0000981; GO:0003143; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0006355; GO:0006357; GO:0007507; GO:0010468; GO:0014883; GO:0030307; GO:0030903; GO:0035329; GO:0042127; GO:0045893; GO:0045944; GO:0048339; GO:0048368; GO:0048568; GO:0065003; GO:0071300; GO:0071902; GO:0140552; GO:1902459; GO:1902895; GO:1990837
GN014932	GN014932.1	Q9GMC9	50.0	100	108	169	2.04e-34	119	TSPO_SHEEP	Translocator protein (Peripheral-type benzodiazepine receptor) (PBR)	Ovis aries (Sheep)		cholesterol binding [GO:0015485]	endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]	GO:0005783; GO:0015485; GO:0031966
GN014934	GN014934.1	Q9NQ86	22.8	281	481	728	3.00e-09	63.2	TRI36_HUMAN	E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728)	Homo sapiens (Human)	acrosome reaction [GO:0007340]; mitotic cytokinesis [GO:0000281]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; regulation of microtubule cytoskeleton organization [GO:0070507]; spindle organization [GO:0007051]	alpha-tubulin binding [GO:0043014]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]	GO:0000209; GO:0000281; GO:0001669; GO:0004842; GO:0005737; GO:0005829; GO:0005856; GO:0007051; GO:0007340; GO:0008270; GO:0043014; GO:0043161; GO:0061630; GO:0070507; GO:0070936
GN014938	GN014938.1	Q5S007	28.6	189	948	2527	3.71e-10	68.2	LRRK2_HUMAN	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	Homo sapiens (Human)	calcium-mediated signaling [GO:0019722]; canonical Wnt signaling pathway [GO:0060070]; cellular response to curcumin [GO:1904644]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; endoplasmic reticulum organization [GO:0007029]; excitatory postsynaptic potential [GO:0060079]; exploration behavior [GO:0035640]; Golgi organization [GO:0007030]; GTP metabolic process [GO:0046039]; intracellular distribution of mitochondria [GO:0048312]; intracellular protein localization [GO:0008104]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; locomotory exploration behavior [GO:0035641]; lysosome organization [GO:0007040]; MAPK cascade [GO:0000165]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of GTPase activity [GO:0034260]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of macroautophagy [GO:0016242]; negative regulation of motile cilium assembly [GO:1905504]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein localization to mitochondrion [GO:1903748]; negative regulation of protein processing [GO:0010955]; neuromuscular junction development [GO:0007528]; neuron projection arborization [GO:0140058]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of tumor necrosis factor production [GO:0032760]; protein autophosphorylation [GO:0046777]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to mitochondrion [GO:0070585]; protein phosphorylation [GO:0006468]; regulation of autophagy [GO:0010506]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of CAMKK-AMPK signaling cascade [GO:1905289]; regulation of cAMP/PKA signal transduction [GO:0141161]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell projection organization [GO:0031344]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of kidney size [GO:0035564]; regulation of locomotion [GO:0040012]; regulation of membrane potential [GO:0042391]; regulation of mitochondrial depolarization [GO:0051900]; regulation of mitochondrial fission [GO:0090140]; regulation of neuroblast proliferation [GO:1902692]; regulation of neuron maturation [GO:0014041]; regulation of protein stability [GO:0031647]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle transport [GO:1902803]; response to oxidative stress [GO:0006979]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; striatum development [GO:0021756]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; Wnt signalosome assembly [GO:1904887]	actin binding [GO:0003779]; ATP binding [GO:0005524]; beta-catenin destruction complex binding [GO:1904713]; clathrin binding [GO:0030276]; co-receptor binding [GO:0039706]; GTP binding [GO:0005525]; GTP-dependent protein kinase activity [GO:0034211]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; microtubule binding [GO:0008017]; peroxidase inhibitor activity [GO:0036479]; protein homodimerization activity [GO:0042803]; protein kinase A binding [GO:0051018]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor complex adaptor activity [GO:0030159]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]; transmembrane transporter binding [GO:0044325]; tubulin binding [GO:0015631]	amphisome [GO:0044753]; autolysosome [GO:0044754]; axon [GO:0030424]; caveola neck [GO:0099400]; cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; growth cone [GO:0030426]; Lewy body [GO:0097413]; lysosome [GO:0005764]; microvillus [GO:0005902]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body, internal vesicle [GO:0097487]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic cytosol [GO:0099523]; ribonucleoprotein complex [GO:1990904]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; trans-Golgi network [GO:0005802]; Wnt signalosome [GO:1990909]	GO:0000139; GO:0000149; GO:0000165; GO:0000287; GO:0003779; GO:0003924; GO:0004672; GO:0004674; GO:0004706; GO:0004709; GO:0005096; GO:0005524; GO:0005525; GO:0005576; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005764; GO:0005768; GO:0005783; GO:0005789; GO:0005794; GO:0005798; GO:0005802; GO:0005829; GO:0005886; GO:0005902; GO:0006468; GO:0006897; GO:0006979; GO:0007005; GO:0007029; GO:0007030; GO:0007040; GO:0007254; GO:0007266; GO:0007283; GO:0007528; GO:0008017; GO:0008104; GO:0008340; GO:0009267; GO:0010506; GO:0010508; GO:0010955; GO:0010977; GO:0014041; GO:0015631; GO:0016242; GO:0016301; GO:0017075; GO:0019722; GO:0021756; GO:0021772; GO:0022028; GO:0030159; GO:0030276; GO:0030424; GO:0030425; GO:0030426; GO:0030672; GO:0031267; GO:0031344; GO:0031398; GO:0031410; GO:0031647; GO:0031966; GO:0032436; GO:0032473; GO:0032760; GO:0032839; GO:0034211; GO:0034260; GO:0034599; GO:0034614; GO:0035542; GO:0035556; GO:0035564; GO:0035640; GO:0035641; GO:0036479; GO:0039706; GO:0040012; GO:0042391; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0043068; GO:0043195; GO:0043204; GO:0043410; GO:0044325; GO:0044753; GO:0044754; GO:0045335; GO:0046039; GO:0046777; GO:0048312; GO:0048812; GO:0051018; GO:0051646; GO:0051900; GO:0051966; GO:0060070; GO:0060079; GO:0060159; GO:0060161; GO:0060628; GO:0060828; GO:0061001; GO:0070062; GO:0070585; GO:0070971; GO:0070973; GO:0071287; GO:0090140; GO:0090263; GO:0090394; GO:0097413; GO:0097487; GO:0098794; GO:0098978; GO:0099400; GO:0099523; GO:0106310; GO:0140058; GO:0141161; GO:1900242; GO:1900244; GO:1901030; GO:1902236; GO:1902499; GO:1902692; GO:1902803; GO:1902823; GO:1902902; GO:1903351; GO:1903748; GO:1903980; GO:1904644; GO:1904713; GO:1904887; GO:1905279; GO:1905289; GO:1905504; GO:1990904; GO:1990909; GO:2000172; GO:2000300; GO:2000377
GN014939	GN014939.1	Q8N5D0	58.3	266	279	677	3.67e-101	312	WDTC1_HUMAN	WD and tetratricopeptide repeats protein 1	Homo sapiens (Human)	negative regulation of adipose tissue development [GO:1904178]; protein ubiquitination [GO:0016567]	enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0004857; GO:0005654; GO:0005829; GO:0016567; GO:0031464; GO:0031465; GO:0042393; GO:0042826; GO:0080008; GO:1904178
GN014940	GN014940.1	Q8N5D0	45.1	355	396	677	1.12e-96	305	WDTC1_HUMAN	WD and tetratricopeptide repeats protein 1	Homo sapiens (Human)	negative regulation of adipose tissue development [GO:1904178]; protein ubiquitination [GO:0016567]	enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0004857; GO:0005654; GO:0005829; GO:0016567; GO:0031464; GO:0031465; GO:0042393; GO:0042826; GO:0080008; GO:1904178
GN014941	GN014941.1	Q08DK4	48.6	247	284	322	2.08e-66	213	GHC1_BOVIN	Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22)	Bos taurus (Bovine)	aspartate transmembrane transport [GO:0015810]; L-glutamate transmembrane transport [GO:0015813]; malate-aspartate shuttle [GO:0043490]; regulation of insulin secretion [GO:0050796]	amino acid:proton symporter activity [GO:0005280]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]	mitochondrial inner membrane [GO:0005743]	GO:0005280; GO:0005313; GO:0005743; GO:0015183; GO:0015810; GO:0015813; GO:0043490; GO:0050796
GN014942	GN014942.1	Q32LJ6	50.4	238	228	236	5.00e-77	234	RABL3_BOVIN	Rab-like protein 3 (EC 3.6.5.2)	Bos taurus (Bovine)	B cell differentiation [GO:0030183]; natural killer cell differentiation [GO:0001779]; positive regulation of cilium assembly [GO:0045724]; protein stabilization [GO:0050821]; regulation of protein lipidation [GO:1903059]; regulation of Ras protein signal transduction [GO:0046578]; T cell differentiation in thymus [GO:0033077]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein homodimerization activity [GO:0042803]	centrosome [GO:0005813]; Golgi apparatus [GO:0005794]	GO:0001779; GO:0003924; GO:0003925; GO:0005525; GO:0005794; GO:0005813; GO:0030183; GO:0033077; GO:0042803; GO:0045724; GO:0046578; GO:0050821; GO:1903059
GN014943	GN014943.1	Q5TH69	30.8	2364	2097	2177	1.24e-300	937	BIG3_HUMAN	Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3)	Homo sapiens (Human)	regulation of ARF protein signal transduction [GO:0032012]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; transport vesicle membrane [GO:0030658]	GO:0005085; GO:0005737; GO:0005794; GO:0030658; GO:0032012
GN014961	GN014961.1	D8VNS7	45.8	225	224	345	3.92e-66	210	FCNV1_CERRY	Ryncolin-1	Cerberus rynchops (Dog-faced water snake)	complement activation, lectin pathway [GO:0001867]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0001867; GO:0003823; GO:0005102; GO:0005576; GO:0097367
GN014963	GN014963.1	A0A345BJN8	25.7	354	584	919	8.17e-24	110	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN014965	GN014965.1	Q92851	28.5	179	415	521	7.54e-10	64.3	CASPA_HUMAN	Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]	Homo sapiens (Human)	apoptotic process [GO:0006915]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of neuron apoptotic process [GO:0043525]; protein maturation [GO:0051604]; proteolysis [GO:0006508]	cysteine-type endopeptidase activity [GO:0004197]; death effector domain binding [GO:0035877]; ubiquitin protein ligase binding [GO:0031625]	CD95 death-inducing signaling complex [GO:0031265]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ripoptosome [GO:0097342]	GO:0004197; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0031265; GO:0031625; GO:0035877; GO:0043123; GO:0043525; GO:0051604; GO:0097342; GO:1900119
GN014968	GN014968.1	P00432	70.4	500	516	527	7.10e-267	739	CATA_BOVIN	Catalase (EC 1.11.1.6)	Bos taurus (Bovine)	hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979]	catalase activity [GO:0004096]; enzyme binding [GO:0019899]; heme binding [GO:0020037]	catalase complex [GO:0062151]; mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0004096; GO:0005739; GO:0005777; GO:0005782; GO:0006979; GO:0019899; GO:0020037; GO:0042744; GO:0062151
GN014969	GN014969.1	Q9PWF7	61.0	492	492	528	8.89e-219	616	CATA_GLARU	Catalase (EC 1.11.1.6)	Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)	hydrogen peroxide catabolic process [GO:0042744]; response to hydrogen peroxide [GO:0042542]	catalase activity [GO:0004096]; heme binding [GO:0020037]	mitochondrion [GO:0005739]; peroxisomal matrix [GO:0005782]	GO:0004096; GO:0005739; GO:0005782; GO:0020037; GO:0042542; GO:0042744
GN014970	GN014970.1	P70080	65.8	450	485	445	1.63e-218	612	TPH1_CHICK	Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1)	Gallus gallus (Chicken)	aromatic amino acid metabolic process [GO:0009072]; platelet degranulation [GO:0002576]; regulation of hemostasis [GO:1900046]; serotonin biosynthetic process [GO:0042427]	iron ion binding [GO:0005506]; tryptophan 5-monooxygenase activity [GO:0004510]	neuron projection [GO:0043005]	GO:0002576; GO:0004510; GO:0005506; GO:0009072; GO:0042427; GO:0043005; GO:1900046
GN014971	GN014971.1	Q9W021	42.1	126	164	150	3.06e-20	84.7	RM23_DROME	Large ribosomal subunit protein uL23m (39S ribosomal protein L23, mitochondrial) (L23mt) (MRP-L23)	Drosophila melanogaster (Fruit fly)	mitochondrial translation [GO:0032543]	structural constituent of ribosome [GO:0003735]	mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005762; GO:0032543
GN014972	GN014972.1	O89110	32.9	161	468	480	3.93e-10	65.5	CASP8_MOUSE	Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]	Mus musculus (Mouse)	angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cardiac muscle tissue development [GO:0048738]; cellular response to mechanical stimulus [GO:0071260]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; heart development [GO:0007507]; hepatocyte apoptotic process [GO:0097284]; macrophage differentiation [GO:0030225]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of necroptotic process [GO:0060546]; neural tube formation [GO:0001841]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of proteolysis [GO:0045862]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of cytokine production [GO:0001817]; regulation of innate immune response [GO:0045088]; regulation of thymocyte apoptotic process [GO:0070243]; response to ethanol [GO:0045471]; response to tumor necrosis factor [GO:0034612]; self proteolysis [GO:0097264]; TRAIL-activated apoptotic signaling pathway [GO:0036462]	cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; cysteine-type endopeptidase activity [GO:0004197]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]	caspase complex [GO:0008303]; CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; lamellipodium [GO:0030027]; mitochondrion [GO:0005739]; Noc1p-Noc2p complex [GO:0030690]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ripoptosome [GO:0097342]	GO:0001525; GO:0001817; GO:0001841; GO:0004175; GO:0004197; GO:0005123; GO:0005164; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006508; GO:0006915; GO:0007507; GO:0008233; GO:0008303; GO:0008625; GO:0008656; GO:0016485; GO:0030027; GO:0030163; GO:0030225; GO:0030335; GO:0030690; GO:0031264; GO:0031265; GO:0031625; GO:0032731; GO:0032991; GO:0034612; GO:0035877; GO:0036462; GO:0042802; GO:0043065; GO:0043123; GO:0043124; GO:0043525; GO:0044297; GO:0044877; GO:0045088; GO:0045471; GO:0045651; GO:0045862; GO:0048738; GO:0051604; GO:0060546; GO:0070243; GO:0070269; GO:0071260; GO:0097110; GO:0097190; GO:0097191; GO:0097194; GO:0097264; GO:0097284; GO:0097342; GO:0140639; GO:1900119; GO:2001233; GO:2001238
GN014974	GN014974.1	D3Z5S8	63.8	320	389	447	6.44e-140	409	TET5A_MOUSE	Terminal nucleotidyltransferase 5A (EC 2.7.7.19)	Mus musculus (Mouse)	mRNA stabilization [GO:0048255]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of ossification [GO:0030278]; response to bacterium [GO:0009617]	poly(A) RNA polymerase activity [GO:1990817]	cytoplasm [GO:0005737]	GO:0005737; GO:0009617; GO:0030278; GO:0030501; GO:0045669; GO:0048255; GO:1990817
GN014977	GN014977.1	P21839	72.3	364	373	392	8.95e-200	558	ODBB_BOVIN	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta)	Bos taurus (Bovine)	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA [GO:0120552]; response to nutrient [GO:0007584]	branched-chain 2-oxo acid dehydrogenase activity [GO:0003863]	branched-chain alpha-ketoacid dehydrogenase complex [GO:0160157]; mitochondrial matrix [GO:0005759]	GO:0003863; GO:0005759; GO:0007584; GO:0120552; GO:0160157
GN014978	GN014978.1	O95260	49.7	485	443	518	2.57e-137	407	ATE1_HUMAN	Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1)	Homo sapiens (Human)	proteasomal protein catabolic process [GO:0010498]; protein arginylation [GO:0016598]; response to oxidative stress [GO:0006979]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596]	arginyl-tRNA--protein transferase activity [GO:0004057]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004057; GO:0005634; GO:0005654; GO:0005737; GO:0006511; GO:0006979; GO:0010498; GO:0016598; GO:0071596
GN014980	GN014980.1	Q9Y5L4	56.0	91	92	95	1.34e-30	106	TIM13_HUMAN	Mitochondrial import inner membrane translocase subunit Tim13	Homo sapiens (Human)	protein insertion into mitochondrial inner membrane [GO:0045039]	zinc ion binding [GO:0008270]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space chaperone complex [GO:0042719]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0005758; GO:0008270; GO:0042719; GO:0045039
GN014981	GN014981.1	Q5JWR5	35.2	1575	1443	2465	4.08e-233	743	DOP1A_HUMAN	Protein DOP1A	Homo sapiens (Human)	Golgi to endosome transport [GO:0006895]		cytosol [GO:0005829]; endolysosome [GO:0036019]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0005768; GO:0005783; GO:0005794; GO:0005802; GO:0005829; GO:0006895; GO:0036019
GN014983	GN014983.1	Q8TBB0	41.5	82	139	222	4.88e-13	66.6	THAP6_HUMAN	THAP domain-containing protein 6	Homo sapiens (Human)			microtubule cytoskeleton [GO:0015630]	GO:0015630
GN014984	GN014984.1	Q6DBY9	26.7	359	442	420	2.66e-21	99.0	CHST1_DANRE	Carbohydrate sulfotransferase 1 (EC 2.8.2.21) (Keratan sulfate Gal-6 sulfotransferase) (KS6ST) (KSGal6ST) (KSST)	Danio rerio (Zebrafish) (Brachydanio rerio)	carbohydrate metabolic process [GO:0005975]; keratan sulfate proteoglycan metabolic process [GO:0042339]; N-acetylglucosamine metabolic process [GO:0006044]; sulfur compound metabolic process [GO:0006790]	keratan sulfotransferase activity [GO:0045130]; N-acetylglucosamine 6-O-sulfotransferase activity [GO:0001517]	Golgi membrane [GO:0000139]	GO:0000139; GO:0001517; GO:0005975; GO:0006044; GO:0006790; GO:0042339; GO:0045130
GN014987	GN014987.1	Q3B8D7	41.8	122	206	177	1.14e-25	100	DYL5A_XENLA	Dynein light chain Tctex-type 5-A (Tctex1 domain-containing protein 1-A)	Xenopus laevis (African clawed frog)	microtubule-based movement [GO:0007018]	dynein intermediate chain binding [GO:0045505]	cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]	GO:0005737; GO:0005868; GO:0007018; GO:0045505
GN014989	GN014989.1	Q9FWW3	30.7	316	386	470	2.19e-40	152	GSXL6_ARATH	Flavin-containing monooxygenase FMO GS-OX-like 6 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 6)	Arabidopsis thaliana (Mouse-ear cress)	glucosinolate biosynthetic process [GO:0019761]; response to abscisic acid [GO:0009737]; response to jasmonic acid [GO:0009753]; response to salicylic acid [GO:0009751]	flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	nucleus [GO:0005634]	GO:0004499; GO:0005634; GO:0009737; GO:0009751; GO:0009753; GO:0019761; GO:0050660; GO:0050661
GN014990	GN014990.1	Q9FWW3	34.0	315	384	470	3.98e-45	164	GSXL6_ARATH	Flavin-containing monooxygenase FMO GS-OX-like 6 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 6)	Arabidopsis thaliana (Mouse-ear cress)	glucosinolate biosynthetic process [GO:0019761]; response to abscisic acid [GO:0009737]; response to jasmonic acid [GO:0009753]; response to salicylic acid [GO:0009751]	flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	nucleus [GO:0005634]	GO:0004499; GO:0005634; GO:0009737; GO:0009751; GO:0009753; GO:0019761; GO:0050660; GO:0050661
GN014991	GN014991.1	Q5LT63	30.3	284	299	450	8.81e-33	128	TMM_RUEPO	Trimethylamine monooxygenase (TMA monooxygenase) (Tmm) (EC 1.14.13.148)	Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]		GO:0004499; GO:0034899; GO:0050660; GO:0050661
GN014992	GN014992.1	B8EIZ7	33.5	397	451	451	2.57e-57	198	TMM_METSB	Trimethylamine monooxygenase (TMA monooxygenase) (Tmm) (EC 1.14.13.148)	Methylocella silvestris (strain DSM 15510 / CIP 108128 / LMG 27833 / NCIMB 13906 / BL2)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]		GO:0004499; GO:0034899; GO:0050660; GO:0050661
GN014993	GN014993.1	Q9VHK6	78.8	151	156	154	7.63e-82	241	ISCU_DROME	Iron-sulfur cluster assembly enzyme IscU (fIscU)	Drosophila melanogaster (Fruit fly)	[2Fe-2S] cluster assembly [GO:0044571]; intracellular iron ion homeostasis [GO:0006879]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]	2 iron, 2 sulfur cluster binding [GO:0051537]; ferrous iron binding [GO:0008198]; iron-sulfur cluster chaperone activity [GO:0140132]	mitochondrial [2Fe-2S] assembly complex [GO:0099128]; mitochondrial matrix [GO:0005759]	GO:0005759; GO:0006879; GO:0008198; GO:0044571; GO:0051537; GO:0099128; GO:0140132; GO:1902958
GN014994	GN014994.1	Q9JK66	42.0	467	417	465	9.72e-120	359	PRKN_RAT	E3 ubiquitin-protein ligase parkin (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase)	Rattus norvegicus (Rat)	adult locomotory behavior [GO:0008344]; aggresome assembly [GO:0070842]; autophagy of mitochondrion [GO:0000422]; cellular response to hydrogen sulfide [GO:1904881]; cellular response to L-glutamate [GO:1905232]; cellular response to L-glutamine [GO:1904845]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; dopamine metabolic process [GO:0042417]; dopamine uptake involved in synaptic transmission [GO:0051583]; free ubiquitin chain polymerization [GO:0010994]; host-mediated suppression of viral genome replication [GO:0044828]; learning [GO:0007612]; locomotory behavior [GO:0007626]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; mitochondrion to lysosome vesicle-mediated transport [GO:0099074]; mitophagy [GO:0000423]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of gene expression [GO:0010629]; negative regulation of glucokinase activity [GO:0033132]; negative regulation of insulin secretion [GO:0046676]; negative regulation of intralumenal vesicle formation [GO:1905366]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; negative regulation of JNK cascade [GO:0046329]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of spontaneous neurotransmitter secretion [GO:1904049]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron cellular homeostasis [GO:0070050]; norepinephrine metabolic process [GO:0042415]; positive regulation of apoptotic process [GO:0043065]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of dendrite extension [GO:1903861]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitochondrial fusion [GO:0010636]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of mitophagy [GO:1901526]; positive regulation of neurotransmitter uptake [GO:0051582]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; positive regulation of type 2 mitophagy [GO:1905091]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of autophagy [GO:0010506]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of dopamine metabolic process [GO:0042053]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of neurotransmitter secretion [GO:0046928]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of protein stability [GO:0031647]; regulation of protein ubiquitination [GO:0031396]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation protein catabolic process at presynapse [GO:0140251]; response to corticosterone [GO:0051412]; response to curcumin [GO:1904643]; response to endoplasmic reticulum stress [GO:0034976]; response to muscle activity [GO:0014850]; response to oxidative stress [GO:0006979]; response to unfolded protein [GO:0006986]; response to xenobiotic stimulus [GO:0009410]; startle response [GO:0001964]; synaptic transmission, dopaminergic [GO:0001963]; synaptic transmission, glutamatergic [GO:0035249]; type 2 mitophagy [GO:0061734]; ubiquitin-dependent protein catabolic process [GO:0006511]	actin binding [GO:0003779]; beta-catenin binding [GO:0008013]; cullin family protein binding [GO:0097602]; enzyme binding [GO:0019899]; F-box domain binding [GO:1990444]; G protein-coupled receptor binding [GO:0001664]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; PDZ domain binding [GO:0030165]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transcription corepressor activity [GO:0003714]; tubulin binding [GO:0015631]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-specific protease binding [GO:1990381]; zinc ion binding [GO:0008270]	aggresome [GO:0016235]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular vesicle [GO:0097708]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; mitochondrion-derived vesicle [GO:0099073]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; ubiquitin ligase complex [GO:0000151]	GO:0000122; GO:0000139; GO:0000151; GO:0000209; GO:0000266; GO:0000422; GO:0000423; GO:0001664; GO:0001963; GO:0001964; GO:0003714; GO:0003779; GO:0004842; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005783; GO:0005789; GO:0005794; GO:0005829; GO:0006511; GO:0006513; GO:0006979; GO:0006986; GO:0007005; GO:0007612; GO:0007626; GO:0008013; GO:0008021; GO:0008270; GO:0008344; GO:0009410; GO:0010498; GO:0010506; GO:0010628; GO:0010629; GO:0010636; GO:0010637; GO:0010821; GO:0010918; GO:0010994; GO:0014069; GO:0014850; GO:0015631; GO:0016235; GO:0016567; GO:0016607; GO:0019899; GO:0019900; GO:0019901; GO:0030163; GO:0030165; GO:0030424; GO:0030544; GO:0030672; GO:0031072; GO:0031396; GO:0031624; GO:0031625; GO:0031647; GO:0031648; GO:0032232; GO:0032436; GO:0032991; GO:0033132; GO:0034599; GO:0034976; GO:0035249; GO:0035774; GO:0042053; GO:0042415; GO:0042417; GO:0042802; GO:0042826; GO:0043005; GO:0043025; GO:0043065; GO:0043123; GO:0043130; GO:0043161; GO:0043195; GO:0043274; GO:0043524; GO:0043653; GO:0044314; GO:0044828; GO:0044877; GO:0045202; GO:0045944; GO:0046329; GO:0046676; GO:0046928; GO:0048471; GO:0050804; GO:0050821; GO:0051087; GO:0051412; GO:0051582; GO:0051583; GO:0051646; GO:0051865; GO:0051881; GO:0051967; GO:0061630; GO:0061734; GO:0070050; GO:0070534; GO:0070585; GO:0070842; GO:0070936; GO:0070979; GO:0071287; GO:0085020; GO:0090090; GO:0090141; GO:0090201; GO:0090258; GO:0090394; GO:0097237; GO:0097602; GO:0097708; GO:0098691; GO:0098793; GO:0098794; GO:0098978; GO:0099072; GO:0099073; GO:0099074; GO:0140251; GO:1900242; GO:1900407; GO:1901526; GO:1901800; GO:1902236; GO:1902254; GO:1902530; GO:1903265; GO:1903377; GO:1903382; GO:1903427; GO:1903542; GO:1903861; GO:1904049; GO:1904643; GO:1904845; GO:1904881; GO:1905091; GO:1905232; GO:1905366; GO:1905477; GO:1990381; GO:1990444; GO:1990452; GO:2000377; GO:2000378; GO:2001171
GN014996	GN014996.1	D8VNS7	49.6	137	156	345	1.16e-38	137	FCNV1_CERRY	Ryncolin-1	Cerberus rynchops (Dog-faced water snake)	complement activation, lectin pathway [GO:0001867]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0001867; GO:0003823; GO:0005102; GO:0005576; GO:0097367
GN014999	GN014999.1	Q8CI66	32.3	356	442	399	8.21e-58	198	STML1_MOUSE	Stomatin-like protein 1 (SLP-1)	Mus musculus (Mouse)	cellular response to leukemia inhibitory factor [GO:1990830]	ion channel inhibitor activity [GO:0008200]	cytoplasmic vesicle [GO:0031410]; late endosome membrane [GO:0031902]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0005886; GO:0008200; GO:0031410; GO:0031902; GO:0045121; GO:1990830
GN015003	GN015003.1	Q8MSU3	32.0	359	749	647	2.48e-39	158	FRRS1_DROME	Ferric reductase 1 (EC 1.-.-.-) (stromal cell-derived receptor 2)	Drosophila melanogaster (Fruit fly)	intracellular iron ion homeostasis [GO:0006879]	oxidoreductase activity, acting on metal ions [GO:0016722]; transmembrane ascorbate ferrireductase activity [GO:0140571]	membrane [GO:0016020]	GO:0006879; GO:0016020; GO:0016722; GO:0140571
GN015004	GN015004.1	P10959	29.0	525	511	549	8.00e-50	182	EST1C_RAT	Carboxylesterase 1C (EC 3.1.1.1) (Carboxyesterase ES-1) (E1) (ES-THET) (Esterase-2) (Liver carboxylesterase 1) (Neutral retinyl ester hydrolase) (NREH) (Retinyl ester hydrolase) (REH)	Rattus norvegicus (Rat)	short-chain fatty acid catabolic process [GO:0019626]	carboxylesterase activity [GO:0106435]; protein homodimerization activity [GO:0042803]; retinyl-palmitate esterase activity [GO:0050253]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; lipid droplet [GO:0005811]	GO:0005783; GO:0005788; GO:0005811; GO:0019626; GO:0042803; GO:0050253; GO:0106435
GN015005	GN015005.1	P21927	33.1	550	562	581	1.68e-66	229	CHLE_RABIT	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	Oryctolagus cuniculus (Rabbit)	acetylcholine catabolic process [GO:0006581]; choline metabolic process [GO:0019695]	acetylcholinesterase activity [GO:0003990]; cholinesterase activity [GO:0004104]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0003990; GO:0004104; GO:0005576; GO:0005886; GO:0006581; GO:0019695
GN015007	GN015007.1	P06276	33.7	513	519	602	1.89e-63	220	CHLE_HUMAN	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	Homo sapiens (Human)	acetylcholine catabolic process [GO:0006581]; choline metabolic process [GO:0019695]; cocaine catabolic process [GO:0050784]; learning [GO:0007612]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of synaptic transmission [GO:0050805]; neuroblast differentiation [GO:0014016]; peptide hormone processing [GO:0016486]; response to alkaloid [GO:0043279]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384]; xenobiotic metabolic process [GO:0006805]	acetylcholinesterase activity [GO:0003990]; amyloid-beta binding [GO:0001540]; catalytic activity [GO:0003824]; choline binding [GO:0033265]; cholinesterase activity [GO:0004104]; enzyme binding [GO:0019899]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]	blood microparticle [GO:0072562]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; nuclear envelope lumen [GO:0005641]; plasma membrane [GO:0005886]	GO:0001540; GO:0003824; GO:0003990; GO:0004104; GO:0005576; GO:0005641; GO:0005788; GO:0005886; GO:0006581; GO:0006805; GO:0007612; GO:0008285; GO:0014016; GO:0016486; GO:0016788; GO:0019695; GO:0019899; GO:0033265; GO:0042802; GO:0043279; GO:0050784; GO:0050805; GO:0051384; GO:0051593; GO:0072562
GN015008	GN015008.1	Q9Z0R4	48.7	1800	1700	1714	0.0	1214	ITSN1_MOUSE	Intersectin-1 (EH and SH3 domains protein 1)	Mus musculus (Mouse)	cell-cell signaling [GO:0007267]; clathrin-dependent synaptic vesicle endocytosis [GO:0150007]; endocytosis [GO:0006897]; intracellular protein localization [GO:0008104]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of postsynapse organization [GO:0099175]; small GTPase-mediated signal transduction [GO:0007264]; synaptic vesicle endocytosis [GO:0048488]	calcium ion binding [GO:0005509]; guanyl-nucleotide exchange factor activity [GO:0005085]; kinase activator activity [GO:0019209]; molecular adaptor activity [GO:0060090]; proline-rich region binding [GO:0070064]; protein-macromolecule adaptor activity [GO:0030674]	apical dendrite [GO:0097440]; calyx of Held [GO:0044305]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; intracellular vesicle [GO:0097708]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic actin cytoskeleton [GO:0098871]; postsynaptic endocytic zone [GO:0098843]; presynaptic endocytic zone [GO:0098833]; recycling endosome [GO:0055037]	GO:0005085; GO:0005509; GO:0005635; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0005886; GO:0005905; GO:0006897; GO:0007264; GO:0007267; GO:0008104; GO:0012505; GO:0019209; GO:0030027; GO:0030139; GO:0030674; GO:0031410; GO:0043025; GO:0043197; GO:0043524; GO:0044305; GO:0048488; GO:0051897; GO:0055037; GO:0060090; GO:0060124; GO:0060999; GO:0070064; GO:0097440; GO:0097708; GO:0098833; GO:0098843; GO:0098871; GO:0098978; GO:0099175; GO:0150007; GO:1905274; GO:2001288
GN015011	GN015011.1	P19477	48.6	138	147	282	2.87e-39	136	FIBA_APOPA	Fibrinogen-like protein A (FREP-A)	Apostichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis)				
GN015012	GN015012.1	Q9U8W7	47.2	72	72	316	6.48e-17	75.5	TL5B_TACTR	Techylectin-5B	Tachypleus tridentatus (Japanese horseshoe crab)	cell-cell adhesion [GO:0098609]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]	carbohydrate binding [GO:0030246]; extracellular matrix structural constituent [GO:0005201]; protein-macromolecule adaptor activity [GO:0030674]	fibrinogen complex [GO:0005577]	GO:0005201; GO:0005577; GO:0030246; GO:0030674; GO:0034116; GO:0098609
GN015014	GN015014.1	E2IYB3	48.6	72	97	221	3.54e-18	78.6	FCNV1_VARKO	Veficolin-1	Varanus komodoensis (Komodo dragon)	complement activation, lectin pathway [GO:0001867]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0001867; GO:0003823; GO:0005102; GO:0005576; GO:0097367
GN015016	GN015016.1	Q7Q5J5	40.9	66	104	290	1.86e-09	56.2	P47R_ANOGA	Pfs47 receptor (AgP47Rec) (P47Rec)	Anopheles gambiae (African malaria mosquito)			cytoplasm [GO:0005737]	GO:0005737
GN015017	GN015017.1	Q7Q5J5	39.8	133	143	290	3.35e-26	102	P47R_ANOGA	Pfs47 receptor (AgP47Rec) (P47Rec)	Anopheles gambiae (African malaria mosquito)			cytoplasm [GO:0005737]	GO:0005737
GN015018	GN015018.1	Q7Q5J5	34.3	143	145	290	4.77e-15	73.2	P47R_ANOGA	Pfs47 receptor (AgP47Rec) (P47Rec)	Anopheles gambiae (African malaria mosquito)			cytoplasm [GO:0005737]	GO:0005737
GN015030	GN015030.1	Q9BWD1	62.4	234	238	397	5.66e-98	294	THIC_HUMAN	Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase)	Homo sapiens (Human)	farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; fatty acid metabolic process [GO:0006631]; lipid metabolic process [GO:0006629]	acetyl-CoA C-acetyltransferase activity [GO:0003985]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0003985; GO:0005737; GO:0005829; GO:0006629; GO:0006631; GO:0010142; GO:0070062
GN015031	GN015031.1	Q5XI22	62.3	159	173	397	1.88e-62	200	THIC_RAT	Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Cytosolic acetoacetyl-CoA thiolase)	Rattus norvegicus (Rat)	cellular response to fatty acid [GO:0071398]; cellular response to nutrient [GO:0031670]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; fatty acid metabolic process [GO:0006631]; geranylgeranyl diphosphate biosynthetic process [GO:0033386]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; ketone body catabolic process [GO:0046952]; liver development [GO:0001889]; phosphate-containing compound metabolic process [GO:0006796]; zymosterol biosynthetic process [GO:0036197]	acetyl-CoA C-acetyltransferase activity [GO:0003985]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisome [GO:0005777]	GO:0001889; GO:0003985; GO:0005737; GO:0005777; GO:0005829; GO:0006631; GO:0006796; GO:0010142; GO:0019287; GO:0031670; GO:0033386; GO:0033489; GO:0033490; GO:0036197; GO:0046952; GO:0071398
GN015032	GN015032.1	P0CX27	80.2	101	158	106	7.39e-54	168	RL44A_YEAST	Large ribosomal subunit protein eL42A (60S ribosomal protein L42-A) (L41) (YL27) (YP44)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	cytoplasmic translation [GO:0002181]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]	GO:0002181; GO:0003735; GO:0005737; GO:0005829; GO:0022625
GN015033	GN015033.1	A0A0R4IBK5	32.4	2701	2650	5209	0.0	1214	R213A_DANRE	E3 ubiquitin-protein ligase rnf213-alpha (EC 2.3.2.27) (EC 3.6.4.-) (E3 ubiquitin-lipopolysaccharide ligase rnf213-alpha) (EC 2.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha)	Danio rerio (Zebrafish) (Brachydanio rerio)	blood circulation [GO:0008015]; defense response to bacterium [GO:0042742]; lipid droplet formation [GO:0140042]; lipid ubiquitination [GO:0120323]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein K63-linked ubiquitination [GO:0070534]; regulation of angiogenesis [GO:0045765]; regulation of lipid metabolic process [GO:0019216]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511]; xenophagy [GO:0098792]	ATP hydrolysis activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]; lipid droplet [GO:0005811]	GO:0002040; GO:0004842; GO:0005811; GO:0005829; GO:0006511; GO:0008015; GO:0016887; GO:0019216; GO:0042742; GO:0045765; GO:0046872; GO:0061630; GO:0070534; GO:0098792; GO:0120323; GO:0140042; GO:2000051
GN015036	GN015036.1	O60508	69.5	544	571	579	1.69e-292	808	PRP17_HUMAN	Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17)	Homo sapiens (Human)	embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0016607; GO:0071006; GO:0071007; GO:0071013; GO:0071014; GO:0071020; GO:1990403
GN015038	GN015038.1	Q9UPY6	47.2	214	531	502	6.61e-47	174	WASF3_HUMAN	Actin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3)	Homo sapiens (Human)	actin filament polymerization [GO:0030041]; modification of postsynaptic actin cytoskeleton [GO:0098885]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; protein-containing complex assembly [GO:0065003]	actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; protein kinase A regulatory subunit binding [GO:0034237]	cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; postsynapse [GO:0098794]; SCAR complex [GO:0031209]	GO:0003779; GO:0005856; GO:0030027; GO:0030041; GO:0031209; GO:0034237; GO:0065003; GO:0070062; GO:0071933; GO:0098794; GO:0098885; GO:0098978; GO:2000601
GN015040	GN015040.1	P28227	59.8	550	580	557	9.68e-246	689	MAOX_ANAPL	NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40)	Anas platyrhynchos (Mallard) (Anas boschas)	malate metabolic process [GO:0006108]	malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; NAD binding [GO:0051287]; oxaloacetate decarboxylase activity [GO:0008948]	mitochondrion [GO:0005739]	GO:0004473; GO:0005739; GO:0006108; GO:0008948; GO:0051287
GN015041	GN015041.1	Q96DA2	58.0	193	214	213	2.04e-84	252	RB39B_HUMAN	Ras-related protein Rab-39B (EC 3.6.5.2)	Homo sapiens (Human)	Rab protein signal transduction [GO:0032482]; regulation of autophagy [GO:0010506]; synapse organization [GO:0050808]; vesicle-mediated transport [GO:0016192]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]	autolysosome membrane [GO:0120281]; autophagosome membrane [GO:0000421]; cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GO:0000421; GO:0003924; GO:0003925; GO:0005525; GO:0005794; GO:0005886; GO:0010506; GO:0016192; GO:0030659; GO:0031489; GO:0031982; GO:0032482; GO:0043005; GO:0050808; GO:0120281
GN015043	GN015043.1	Q9UPX8	54.4	386	879	1849	5.75e-119	401	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)	Homo sapiens (Human)	adult behavior [GO:0030534]; associative learning [GO:0008306]; learning [GO:0007612]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; negative regulation of hippo signaling [GO:0035331]; positive regulation of cell population proliferation [GO:0008284]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; vocalization behavior [GO:0071625]	ionotropic glutamate receptor binding [GO:0035255]; synaptic receptor adaptor activity [GO:0030160]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; ciliary membrane [GO:0060170]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; growth cone [GO:0030426]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	GO:0001750; GO:0001917; GO:0005829; GO:0005886; GO:0007416; GO:0007612; GO:0008284; GO:0008306; GO:0014069; GO:0016324; GO:0030160; GO:0030426; GO:0030534; GO:0031526; GO:0035176; GO:0035255; GO:0035331; GO:0043005; GO:0043025; GO:0043197; GO:0050808; GO:0060170; GO:0060291; GO:0060292; GO:0071625
GN015044	GN015044.1	Q9QX74	55.2	105	1768	1474	2.78e-22	108	SHAN2_RAT	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (GKAP/SAPAP-interacting protein) (Proline-rich synapse-associated protein 1) (ProSAP1) (SPANK-3)	Rattus norvegicus (Rat)	adult behavior [GO:0030534]; adult locomotory behavior [GO:0008344]; associative learning [GO:0008306]; exploration behavior [GO:0035640]; learning [GO:0007612]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; negative regulation of hippo signaling [GO:0035331]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of postsynapse organization [GO:0099175]; response to nutrient [GO:0007584]; response to xenobiotic stimulus [GO:0009410]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625]	ionotropic glutamate receptor binding [GO:0035255]; SH3 domain binding [GO:0017124]; structural constituent of postsynaptic density [GO:0098919]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; ciliary membrane [GO:0060170]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neurofilament [GO:0005883]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]	GO:0001750; GO:0001917; GO:0005883; GO:0005886; GO:0007416; GO:0007584; GO:0007612; GO:0007613; GO:0008284; GO:0008306; GO:0008344; GO:0009410; GO:0014069; GO:0016324; GO:0017124; GO:0030426; GO:0030534; GO:0031526; GO:0035176; GO:0035255; GO:0035331; GO:0035640; GO:0043005; GO:0043025; GO:0043197; GO:0045211; GO:0048786; GO:0051968; GO:0060170; GO:0060291; GO:0060292; GO:0071625; GO:0098686; GO:0098919; GO:0098978; GO:0099175
GN015045	GN015045.1	Q9EPT5	28.1	626	670	643	2.14e-78	265	SO2A1_MOUSE	Solute carrier organic anion transporter family member 2A1 (SLCO2A1) (OATP2A1) (PHOAR2) (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2) (SLC21A2)	Mus musculus (Mouse)	prostaglandin transport [GO:0015732]; sodium-independent organic anion transport [GO:0043252]	lipid carrier activity [GO:0005319]; prostaglandin transmembrane transporter activity [GO:0015132]; secondary active transmembrane transporter activity [GO:0015291]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0005319; GO:0005764; GO:0005886; GO:0009925; GO:0015132; GO:0015291; GO:0015732; GO:0016323; GO:0043252
GN015048	GN015048.1	F1QC17	39.4	127	119	1014	2.45e-10	59.7	EMI1A_DANRE	EMILIN-1-A (Elastin microfibril interfacer 1a)	Danio rerio (Zebrafish) (Brachydanio rerio)	axon arborization [GO:0140060]; hemopoiesis [GO:0030097]			GO:0030097; GO:0140060
GN015052	GN015052.1	Q5FWR0	50.0	654	916	1003	4.12e-215	640	SMRCD_XENTR	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.-)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	DNA double-strand break processing [GO:0000729]; positive regulation of transcription by RNA polymerase II [GO:0045944]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; ubiquitin binding [GO:0043130]	chromosome [GO:0005694]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000729; GO:0005524; GO:0005634; GO:0005694; GO:0016887; GO:0035861; GO:0043130; GO:0045944; GO:0140658
GN015053	GN015053.1	Q13201	32.2	149	395	1228	3.91e-09	62.4	MMRN1_HUMAN	Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)]	Homo sapiens (Human)	blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of wound healing [GO:0061045]; positive regulation of platelet aggregation [GO:1901731]	calcium ion binding [GO:0005509]	endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; multimerin complex [GO:1990972]; non-collagenous component of basement membrane [GO:0140144]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]	GO:0005509; GO:0005576; GO:0005788; GO:0007155; GO:0007596; GO:0030948; GO:0031012; GO:0031091; GO:0031093; GO:0033627; GO:0061045; GO:0090051; GO:0140144; GO:1901731; GO:1990972
GN015056	GN015056.1	Q4R8T1	21.8	629	1101	646	2.78e-26	119	EFCB6_MACFA	EF-hand calcium-binding domain-containing protein 6 (DJ-1-binding protein) (DJBP)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	flagellated sperm motility [GO:0030317]	calcium ion binding [GO:0005509]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005509; GO:0005634; GO:0005654; GO:0030317; GO:0036126
GN015057	GN015057.1	Q86Z23	38.7	106	191	238	1.66e-12	67.0	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN015059	GN015059.1	Q6P1E8	25.4	193	293	1516	1.83e-16	83.2	EFCB6_MOUSE	EF-hand calcium-binding domain-containing protein 6 (DJ-1-binding protein) (DJBP)	Mus musculus (Mouse)	flagellated sperm motility [GO:0030317]	calcium ion binding [GO:0005509]	axonemal A tubule inner sheath [GO:0160111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005509; GO:0005634; GO:0005654; GO:0030317; GO:0036126; GO:0160111
GN015060	GN015060.1	Q86Z23	39.6	106	191	238	1.66e-12	67.0	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN015062	GN015062.1	O00602	50.3	197	301	326	3.19e-59	195	FCN1_HUMAN	Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)	Homo sapiens (Human)	cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; host-mediated suppression of symbiont invasion [GO:0046597]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of opsonization [GO:1903028]; protein localization to cell surface [GO:0034394]; proteolysis [GO:0006508]; recognition of apoptotic cell [GO:0043654]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; G protein-coupled receptor binding [GO:0001664]; pattern recognition receptor activity [GO:0038187]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; serine-type endopeptidase complex [GO:1905370]; symbiont cell surface [GO:0106139]	GO:0001664; GO:0001867; GO:0002752; GO:0003823; GO:0005102; GO:0005576; GO:0005886; GO:0006508; GO:0007186; GO:0009897; GO:0009986; GO:0031012; GO:0032757; GO:0033691; GO:0034394; GO:0034774; GO:0038187; GO:0043654; GO:0046597; GO:0097367; GO:0106139; GO:1903028; GO:1904813; GO:1905370
GN015065	GN015065.1	Q9BWD1	52.9	153	158	397	6.14e-44	152	THIC_HUMAN	Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase)	Homo sapiens (Human)	farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; fatty acid metabolic process [GO:0006631]; lipid metabolic process [GO:0006629]	acetyl-CoA C-acetyltransferase activity [GO:0003985]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0003985; GO:0005737; GO:0005829; GO:0006629; GO:0006631; GO:0010142; GO:0070062
GN015066	GN015066.1	Q9ES30	33.6	128	414	246	9.52e-12	68.2	C1QT3_MOUSE	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	Mus musculus (Mouse)	fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; intracellular triglyceride homeostasis [GO:0035356]; maintenance of synapse structure [GO:0099558]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular region [GO:0005576]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001819; GO:0005576; GO:0010629; GO:0032715; GO:0032991; GO:0035356; GO:0042593; GO:0042802; GO:0043083; GO:0045202; GO:0045444; GO:0045721; GO:0050728; GO:0051897; GO:0070165; GO:0070374; GO:0071638; GO:0099550; GO:0099558; GO:1901223
GN015067	GN015067.1	Q8R066	32.3	127	171	326	3.85e-09	57.8	C1QT4_MOUSE	Complement C1q tumor necrosis factor-related protein 4 (C1q/TNF-related protein 4)	Mus musculus (Mouse)	cell surface receptor signaling pathway via STAT [GO:0097696]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; macrophage activation [GO:0042116]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of tumor necrosis factor production [GO:0032760]; protein import [GO:0017038]; protein phosphorylation [GO:0006468]; reduction of food intake in response to dietary excess [GO:0002023]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; toll-like receptor 4 signaling pathway [GO:0034142]		extracellular region [GO:0005576]	GO:0002023; GO:0005576; GO:0006468; GO:0006954; GO:0009611; GO:0010467; GO:0017038; GO:0032496; GO:0032755; GO:0032760; GO:0034142; GO:0042116; GO:0070105; GO:0097696; GO:1901224
GN015077	GN015077.1	Q6PAL0	42.5	73	104	825	2.51e-12	64.7	BEND3_MOUSE	BEN domain-containing protein 3	Mus musculus (Mouse)	DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of ATP metabolic process [GO:1903580]; protein homooligomerization [GO:0051260]; rDNA heterochromatin formation [GO:0000183]	rDNA binding [GO:0000182]	heterochromatin [GO:0000792]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000182; GO:0000183; GO:0000792; GO:0005634; GO:0005654; GO:0005730; GO:0006346; GO:0051260; GO:1903580
GN015081	GN015081.1	Q9P2Z0	39.5	86	113	257	3.03e-17	77.4	THA10_HUMAN	THAP domain-containing protein 10	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]		GO:0043565
GN015082	GN015082.1	Q8BZM1	28.7	551	617	596	7.68e-61	216	GLMN_MOUSE	Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein)	Mus musculus (Mouse)	cell surface receptor signaling pathway [GO:0007166]; circulatory system development [GO:0072359]; epigenetic regulation of gene expression [GO:0040029]; muscle cell differentiation [GO:0042692]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of T cell proliferation [GO:0042130]; neural tube closure [GO:0001843]; positive regulation of cytokine production [GO:0001819]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of phosphorylation [GO:0042327]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; vasculogenesis [GO:0001570]	hepatocyte growth factor receptor binding [GO:0005171]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase inhibitor activity [GO:0055105]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cullin-RING ubiquitin ligase complex [GO:0031461]	GO:0001570; GO:0001819; GO:0001843; GO:0005102; GO:0005171; GO:0007166; GO:0008285; GO:0031461; GO:0031462; GO:0031463; GO:0031464; GO:0031625; GO:0032434; GO:0032743; GO:0040029; GO:0042130; GO:0042327; GO:0042692; GO:0055105; GO:0072359
GN015106	GN015106.1	B0BN95	41.6	89	107	349	2.31e-17	78.6	HARB1_RAT	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Rattus norvegicus (Rat)			cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005829; GO:0005886
GN015111	GN015111.1	Q24372	31.3	246	349	359	1.27e-36	138	LACH_DROME	Lachesin	Drosophila melanogaster (Fruit fly)	cell adhesion involved in heart morphogenesis [GO:0061343]; homophilic cell-cell adhesion [GO:0007156]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; morphogenesis of embryonic epithelium [GO:0016331]; open tracheal system development [GO:0007424]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]	protein homodimerization activity [GO:0042803]	neuron projection [GO:0043005]; plasma membrane [GO:0005886]; septate junction [GO:0005918]	GO:0005886; GO:0005918; GO:0007156; GO:0007424; GO:0016331; GO:0019991; GO:0035151; GO:0035160; GO:0042803; GO:0043005; GO:0061343
GN015112	GN015112.1	O75351	40.1	274	359	444	5.60e-65	215	VPS4B_HUMAN	Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1)	Homo sapiens (Human)	autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; endosomal transport [GO:0016197]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ESCRT III complex disassembly [GO:1904903]; late endosomal microautophagy [GO:0061738]; late endosome to lysosome transport via multivesicular body sorting pathway [GO:0061764]; macroautophagy [GO:0016236]; membrane fission [GO:0090148]; midbody abscission [GO:0061952]; mitotic metaphase chromosome alignment [GO:0007080]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; negative regulation of exosomal secretion [GO:1903542]; nuclear membrane reassembly [GO:0031468]; nucleus organization [GO:0006997]; plasma membrane repair [GO:0001778]; positive regulation of centriole elongation [GO:1903724]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein depolymerization [GO:0051261]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; response to lipid [GO:0033993]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding from plasma membrane [GO:0046761]; viral budding via host ESCRT complex [GO:0039702]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]	ATPase complex [GO:1904949]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome membrane [GO:0031902]; midbody [GO:0030496]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]	GO:0000922; GO:0001778; GO:0005524; GO:0005634; GO:0005643; GO:0005737; GO:0005768; GO:0005813; GO:0005829; GO:0005886; GO:0006914; GO:0006997; GO:0007080; GO:0010008; GO:0010824; GO:0010971; GO:0016197; GO:0016236; GO:0016887; GO:0030496; GO:0031468; GO:0031902; GO:0032510; GO:0033993; GO:0036258; GO:0039702; GO:0042802; GO:0042803; GO:0043162; GO:0044877; GO:0046761; GO:0051261; GO:0061738; GO:0061764; GO:0061952; GO:0070062; GO:0071985; GO:0090148; GO:0090543; GO:0090611; GO:0097352; GO:1901673; GO:1903542; GO:1903543; GO:1903724; GO:1904903; GO:1904949
GN015113	GN015113.1	P22031	41.9	93	122	105	3.19e-19	79.3	LEG_HELCR	D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL)	Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina)		carbohydrate binding [GO:0030246]	cytoplasm [GO:0005737]	GO:0005737; GO:0030246
GN015117	GN015117.1	P70031	35.3	119	162	453	3.01e-14	72.4	CCKAR_XENLA	Cholecystokinin receptor (CCK-XLR)	Xenopus laevis (African clawed frog)	neuropeptide signaling pathway [GO:0007218]	neuropeptide receptor activity [GO:0008188]	plasma membrane [GO:0005886]	GO:0005886; GO:0007218; GO:0008188
GN015119	GN015119.1	P38766	36.8	307	389	723	1.82e-46	172	RRM3_YEAST	ATP-dependent DNA helicase RRM3 (EC 5.6.2.3) (DNA 5'-3' helicase RRM3) (Regulation of Ty1 transposition protein 104) (rDNA recombination mutation protein 3)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	DNA repair [GO:0006281]; DNA replication [GO:0006260]; replication fork progression beyond termination site [GO:0097046]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; centromeric DNA binding [GO:0019237]; DNA helicase activity [GO:0003678]; G-quadruplex DNA binding [GO:0051880]; single-stranded DNA binding [GO:0003697]	chromosome, telomeric region [GO:0000781]; mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; replication fork [GO:0005657]	GO:0000723; GO:0000781; GO:0003678; GO:0003697; GO:0005524; GO:0005657; GO:0005739; GO:0006260; GO:0006281; GO:0016887; GO:0019237; GO:0043139; GO:0043596; GO:0051880; GO:0071932; GO:0097046
GN015132	GN015132.1	Q5FPE5	41.9	105	133	266	6.84e-14	69.3	GMDH_GLUOX	Glucose 1-dehydrogenase (EC 1.1.1.119)	Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)		glucose 1-dehydrogenase (NADP+) activity [GO:0047935]		GO:0047935
GN015133	GN015133.1	Q21929	37.1	116	165	251	3.60e-19	84.3	DCXR_CAEEL	L-xylulose reductase (XR) (EC 1.1.1.10) (Dicarbonyl/L-xylulose reductase) (DCXR) (Short-chain dehydrogenase 21)	Caenorhabditis elegans	glucose metabolic process [GO:0006006]; xylulose catabolic process [GO:0005998]; xylulose metabolic process [GO:0005997]	carbonyl reductase (NADPH) activity [GO:0004090]; catalytic activity [GO:0003824]; L-xylulose reductase (NADPH) activity [GO:0050038]	plasma membrane [GO:0005886]	GO:0003824; GO:0004090; GO:0005886; GO:0005997; GO:0005998; GO:0006006; GO:0050038
GN015135	GN015135.1	Q9Y466	57.5	386	380	385	5.59e-151	434	NR2E1_HUMAN	Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (hTll)	Homo sapiens (Human)	cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of stem cell proliferation [GO:2000648]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; histone deacetylase binding [GO:0042826]; nuclear receptor activity [GO:0004879]; nuclear steroid receptor activity [GO:0003707]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000978; GO:0000981; GO:0001227; GO:0001228; GO:0003707; GO:0004879; GO:0005634; GO:0005654; GO:0007399; GO:0008270; GO:0030154; GO:0042826; GO:1990837; GO:2000179; GO:2000648
GN015136	GN015136.1	Q9YGL3	43.7	158	186	396	4.26e-39	140	NR2E1_ORYLA	Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll)	Oryzias latipes (Japanese rice fish) (Japanese killifish)	cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]	nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0004879; GO:0005634; GO:0005654; GO:0007399; GO:0008270; GO:0030154
GN015137	GN015137.1	V5NAL9	30.7	524	523	899	9.77e-75	256	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN015138	GN015138.1	V5NAL9	32.8	137	141	899	1.47e-17	81.3	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN015139	GN015139.1	V5NAL9	31.0	787	773	899	3.57e-109	357	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN015141	GN015141.1	V5NAL9	32.4	136	141	899	3.71e-17	80.1	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN015148	GN015148.1	Q0P5V2	36.7	281	784	864	2.58e-37	154	SOBP_MOUSE	Sine oculis-binding protein homolog (Jackson circler protein 1)	Mus musculus (Mouse)	animal organ development [GO:0048513]; cochlea development [GO:0090102]; cognition [GO:0050890]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605]	SUMO polymer binding [GO:0032184]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0005634; GO:0007605; GO:0007626; GO:0008270; GO:0032184; GO:0042472; GO:0048513; GO:0050890; GO:0090102
GN015149	GN015149.1	P24463	34.6	492	496	503	1.22e-92	293	CP3AC_CANLF	Cytochrome P450 3A12 (EC 1.14.14.1) (CYPIIIA12) (Cytochrome P450-PBD-1)	Canis lupus familiaris (Dog) (Canis familiaris)	hormone metabolic process [GO:0042445]; oxidative demethylation [GO:0070989]; progesterone metabolic process [GO:0042448]; steroid metabolic process [GO:0008202]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]; testosterone 6-beta-hydroxylase activity [GO:0050649]	endoplasmic reticulum membrane [GO:0005789]	GO:0004497; GO:0005506; GO:0005789; GO:0008202; GO:0008395; GO:0016712; GO:0020037; GO:0042445; GO:0042448; GO:0050649; GO:0070989
GN015152	GN015152.1	A0A2B4RNI3	32.5	163	664	688	7.87e-21	100	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN015154	GN015154.1	Q21920	32.3	158	402	2620	8.50e-10	64.7	ANKHM_CAEEL	Ankyrin repeat and KH domain-containing protein mask-1 (Multiple ankyrin repeats single KH domain homolog)	Caenorhabditis elegans		RNA binding [GO:0003723]	cytoplasm [GO:0005737]	GO:0003723; GO:0005737
GN015157	GN015157.1	Q9GZR1	32.5	679	1792	1112	2.04e-76	281	SENP6_HUMAN	Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6)	Homo sapiens (Human)	protein desumoylation [GO:0016926]; protein modification by small protein removal [GO:0070646]; protein sumoylation [GO:0016925]; proteolysis [GO:0006508]; regulation of kinetochore assembly [GO:0090234]; regulation of spindle assembly [GO:0090169]	SUMO-specific endopeptidase activity [GO:0070139]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0016925; GO:0016926; GO:0070139; GO:0070646; GO:0090169; GO:0090234
GN015159	GN015159.1	Q08174	30.7	332	334	1060	5.56e-40	153	PCDH1_HUMAN	Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42)	Homo sapiens (Human)	cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; homophilic cell-cell adhesion [GO:0007156]; nervous system development [GO:0007399]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]	cell junction [GO:0030054]; cell-cell junction [GO:0005911]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005911; GO:0007155; GO:0007156; GO:0007267; GO:0007399; GO:0030054; GO:0050839
GN015165	GN015165.1	Q13162	76.8	224	249	271	3.73e-126	361	PRDX4_HUMAN	Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4)	Homo sapiens (Human)	hydrogen peroxide catabolic process [GO:0042744]; I-kappaB phosphorylation [GO:0007252]; response to oxidative stress [GO:0006979]	identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; molecular sequestering activity [GO:0140313]; thioredoxin peroxidase activity [GO:0008379]; thioredoxin-dependent peroxiredoxin activity [GO:0140824]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]	GO:0005576; GO:0005634; GO:0005737; GO:0005783; GO:0005829; GO:0006979; GO:0007252; GO:0008379; GO:0034774; GO:0042744; GO:0042802; GO:0060090; GO:0070062; GO:0140313; GO:0140824; GO:1904813
GN015168	GN015168.1	Q9UGM3	34.8	938	883	2413	4.47e-158	515	DMBT1_HUMAN	Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Deleted in malignant brain tumors 1 protein) (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein)	Homo sapiens (Human)	defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]	calcium-dependent protein binding [GO:0048306]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]; phagocytic vesicle membrane [GO:0030670]; zymogen granule membrane [GO:0042589]	GO:0005044; GO:0005576; GO:0005737; GO:0030670; GO:0030855; GO:0031012; GO:0035375; GO:0038187; GO:0042589; GO:0043152; GO:0045087; GO:0048306; GO:0050829; GO:0050830; GO:0070062; GO:0140144
GN015174	GN015174.1	P86787	43.1	58	343	58	6.29e-10	57.8	GIGA4_MAGGI	Gigasin-4	Magallana gigas (Pacific oyster) (Crassostrea gigas)				
GN015176	GN015176.1	P86787	56.9	58	119	58	5.91e-20	79.7	GIGA4_MAGGI	Gigasin-4	Magallana gigas (Pacific oyster) (Crassostrea gigas)				
GN015178	GN015178.1	Q98234	45.6	160	266	220	1.23e-49	166	GPX_MCV1	Glutathione peroxidase (GPx) (GSHPx) (EC 1.11.1.9)	Molluscum contagiosum virus subtype 1 (MOCV) (MCVI)	response to oxidative stress [GO:0006979]	glutathione peroxidase activity [GO:0004602]		GO:0004602; GO:0006979
GN015180	GN015180.1	Q8N6F8	34.9	166	225	245	3.93e-22	94.0	MET27_HUMAN	Methyltransferase-like protein 27 (Williams-Beuren syndrome chromosomal region 27 protein)	Homo sapiens (Human)				
GN015182	GN015182.1	P35282	77.3	207	208	222	6.40e-112	322	RAB21_MOUSE	Ras-related protein Rab-21 (EC 3.6.5.2) (Rab-12)	Mus musculus (Mouse)	anterograde axonal transport [GO:0008089]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein stabilization [GO:0050821]; Rab protein signal transduction [GO:0032482]; regulation of axon extension [GO:0030516]; regulation of exocytosis [GO:0017157]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	axon cytoplasm [GO:1904115]; cleavage furrow [GO:0032154]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; vesicle membrane [GO:0012506]	GO:0000139; GO:0003924; GO:0003925; GO:0005525; GO:0005768; GO:0005769; GO:0005789; GO:0005802; GO:0008089; GO:0009898; GO:0012506; GO:0017157; GO:0019003; GO:0030516; GO:0030659; GO:0031901; GO:0032154; GO:0032482; GO:0032580; GO:0043005; GO:0045202; GO:0048260; GO:0050775; GO:0050821; GO:0098559; GO:1904115; GO:2000643
GN015183	GN015183.1	Q9CXF4	46.2	625	649	671	1.67e-186	546	TBC15_MOUSE	TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP)	Mus musculus (Mouse)	regulation of GTPase activity [GO:0043087]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]	GO:0005096; GO:0005576; GO:0005737; GO:0005739; GO:0005829; GO:0043087
GN015184	GN015184.1	Q9JHG6	49.0	194	296	251	4.40e-54	179	RCAN1_MOUSE	Calcipressin-1 (Down syndrome critical region protein 1 homolog) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1)	Mus musculus (Mouse)	calcineurin-NFAT signaling cascade [GO:0033173]; calcium-mediated signaling [GO:0019722]; locomotion involved in locomotory behavior [GO:0031987]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of smooth muscle cell differentiation [GO:0051151]; response to estrogen [GO:0043627]; response to ischemia [GO:0002931]; response to mechanical stimulus [GO:0009612]; response to oxidative stress [GO:0006979]; response to stress [GO:0006950]; short-term memory [GO:0007614]; skeletal muscle fiber development [GO:0048741]	calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; protein phosphatase inhibitor activity [GO:0004864]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0002931; GO:0003676; GO:0004864; GO:0005634; GO:0005737; GO:0006950; GO:0006979; GO:0007614; GO:0008597; GO:0009612; GO:0019722; GO:0031987; GO:0033173; GO:0042802; GO:0043627; GO:0048741; GO:0051151; GO:0070885
GN015185	GN015185.1	Q4QR85	40.8	321	368	342	3.23e-73	234	MEP50_RAT	Methylosome protein WDR77 (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77)	Rattus norvegicus (Rat)	negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; positive regulation of cell population proliferation [GO:0008284]; protein polyubiquitination [GO:0000209]; regulation of transcription by RNA polymerase II [GO:0006357]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; ubiquitin-dependent protein catabolic process [GO:0006511]	methyl-CpG binding [GO:0008327]; transcription coactivator activity [GO:0003713]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000209; GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006357; GO:0006511; GO:0008284; GO:0008285; GO:0008327; GO:0031465; GO:0034709; GO:0060528; GO:0060770; GO:1990756
GN015193	GN015193.1	Q86Z23	32.9	143	166	238	1.19e-10	61.2	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN015194	GN015194.1	P62070	80.4	163	174	204	6.45e-92	269	RRAS2_HUMAN	Ras-related protein R-Ras2 (EC 3.6.5.2) (Ras-like protein TC21) (Teratocarcinoma oncogene)	Homo sapiens (Human)	establishment or maintenance of cell polarity [GO:0007163]; osteoblast differentiation [GO:0001649]; Ras protein signal transduction [GO:0007265]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0000139; GO:0001649; GO:0003924; GO:0003925; GO:0005525; GO:0005783; GO:0005886; GO:0005925; GO:0007163; GO:0007265; GO:0016020; GO:0070062
GN015195	GN015195.1	Q9WU62	42.3	123	1181	880	1.68e-19	98.6	INCE_MOUSE	Inner centromere protein	Mus musculus (Mouse)	chromosome segregation [GO:0007059]; meiotic spindle midzone assembly [GO:0051257]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of protein phosphorylation [GO:0001934]	molecular function activator activity [GO:0140677]	central element [GO:0000801]; chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; lateral element [GO:0000800]; meiotic spindle midzone [GO:1990385]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; synaptonemal complex [GO:0000795]	GO:0000278; GO:0000281; GO:0000775; GO:0000776; GO:0000795; GO:0000800; GO:0000801; GO:0001934; GO:0005634; GO:0005654; GO:0005721; GO:0005819; GO:0005829; GO:0007052; GO:0007059; GO:0010369; GO:0015630; GO:0016604; GO:0030496; GO:0032133; GO:0032991; GO:0051256; GO:0051257; GO:0051310; GO:0090267; GO:0140677; GO:1901970; GO:1902425; GO:1903490; GO:1990385
GN015199	GN015199.1	Q9WU62	43.1	123	141	880	6.92e-24	99.4	INCE_MOUSE	Inner centromere protein	Mus musculus (Mouse)	chromosome segregation [GO:0007059]; meiotic spindle midzone assembly [GO:0051257]; metaphase chromosome alignment [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; mitotic spindle organization [GO:0007052]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of mitotic cytokinesis [GO:1903490]; positive regulation of mitotic sister chromatid separation [GO:1901970]; positive regulation of protein phosphorylation [GO:0001934]	molecular function activator activity [GO:0140677]	central element [GO:0000801]; chromocenter [GO:0010369]; chromosome passenger complex [GO:0032133]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; kinetochore [GO:0000776]; lateral element [GO:0000800]; meiotic spindle midzone [GO:1990385]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]; protein-containing complex [GO:0032991]; spindle [GO:0005819]; synaptonemal complex [GO:0000795]	GO:0000278; GO:0000281; GO:0000775; GO:0000776; GO:0000795; GO:0000800; GO:0000801; GO:0001934; GO:0005634; GO:0005654; GO:0005721; GO:0005819; GO:0005829; GO:0007052; GO:0007059; GO:0010369; GO:0015630; GO:0016604; GO:0030496; GO:0032133; GO:0032991; GO:0051256; GO:0051257; GO:0051310; GO:0090267; GO:0140677; GO:1901970; GO:1902425; GO:1903490; GO:1990385
GN015201	GN015201.1	Q8VDH1	32.5	126	224	627	2.64e-14	74.7	FBX21_MOUSE	F-box only protein 21	Mus musculus (Mouse)	apoptotic process [GO:0006915]; cytokine-mediated signaling pathway [GO:0019221]; ERK1 and ERK2 cascade [GO:0070371]; hematopoietic stem cell differentiation [GO:0060218]; hematopoietic stem cell homeostasis [GO:0061484]	DNA binding [GO:0003677]		GO:0003677; GO:0006915; GO:0019221; GO:0060218; GO:0061484; GO:0070371
GN015204	GN015204.1	Q8BGT0	30.3	261	296	338	1.01e-30	120	OSTM1_MOUSE	Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit) (Grey-lethal protein)	Mus musculus (Mouse)	osteoclast differentiation [GO:0030316]; transepithelial chloride transport [GO:0030321]		chloride channel complex [GO:0034707]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]	GO:0005765; GO:0005829; GO:0030316; GO:0030321; GO:0034707
GN015205	GN015205.1	Q17RP2	28.7	167	165	521	4.76e-12	66.2	TIGD6_HUMAN	Tigger transposable element-derived protein 6	Homo sapiens (Human)		DNA binding [GO:0003677]	nucleus [GO:0005634]	GO:0003677; GO:0005634
GN015210	GN015210.1	Q0VCJ7	41.9	186	236	199	8.32e-40	139	RERG_BOVIN	Ras-related and estrogen-regulated growth inhibitor (EC 3.6.5.2)	Bos taurus (Bovine)	establishment or maintenance of cell polarity [GO:0007163]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; Ras protein signal transduction [GO:0007265]; response to hormone [GO:0009725]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005525; GO:0005634; GO:0005829; GO:0005886; GO:0007163; GO:0007265; GO:0008285; GO:0009725; GO:0030308
GN015211	GN015211.1	P52844	35.4	280	394	295	1.18e-53	182	ST1E1_RAT	Sulfotransferase 1E1 (ST1E1) (EC 2.8.2.4) (Estrogen sulfotransferase, isoform 1) (EST-1) (Estrogen sulfotransferase, isoform 6) (EST-6) (Estrone sulfotransferase) (Sulfotransferase, estrogen-preferring)	Rattus norvegicus (Rat)	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; estrogen catabolic process [GO:0006711]; estrogen metabolic process [GO:0008210]; ethanol catabolic process [GO:0006068]; female pregnancy [GO:0007565]; positive regulation of fat cell differentiation [GO:0045600]; sulfation [GO:0051923]	estrone sulfotransferase activity [GO:0004304]; flavonol 3-sulfotransferase activity [GO:0047894]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004304; GO:0005737; GO:0005829; GO:0006068; GO:0006711; GO:0007565; GO:0008146; GO:0008210; GO:0045600; GO:0047894; GO:0050294; GO:0050427; GO:0051923
GN015213	GN015213.1	Q61371	60.7	833	817	824	8.36e-255	732	IFT88_MOUSE	Intraflagellar transport protein 88 homolog (Recessive polycystic kidney disease protein Tg737) (Tetratricopeptide repeat protein 10) (TPR repeat protein 10) (TgN(Imorpk)737Rpw)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; cardiac muscle cell differentiation [GO:0055007]; cardiac septum morphogenesis [GO:0060411]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; cochlea development [GO:0090102]; cytoplasmic microtubule organization [GO:0031122]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endothelial cell morphogenesis [GO:0001886]; epidermal stem cell homeostasis [GO:0036334]; epidermis development [GO:0008544]; eye development [GO:0001654]; forebrain development [GO:0030900]; forebrain morphogenesis [GO:0048853]; heart development [GO:0007507]; heart formation [GO:0060914]; inner ear receptor cell stereocilium organization [GO:0060122]; intracellular protein localization [GO:0008104]; intraciliary anterograde transport [GO:0035720]; intraciliary transport [GO:0042073]; kidney development [GO:0001822]; limb development [GO:0060173]; liver development [GO:0001889]; lung development [GO:0030324]; lung vasculature development [GO:0060426]; negative regulation of epithelial cell proliferation [GO:0050680]; nervous system development [GO:0007399]; neural precursor cell proliferation [GO:0061351]; non-motile cilium assembly [GO:1905515]; Notch signaling pathway [GO:0007219]; pancreas development [GO:0031016]; positive regulation of cilium assembly [GO:0045724]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; primary palate development [GO:1903929]; regulation of autophagosome assembly [GO:2000785]; regulation of cilium assembly [GO:1902017]; regulation of fat cell differentiation [GO:0045598]; regulation of feeding behavior [GO:0060259]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of protein processing [GO:0070613]; response to fluid shear stress [GO:0034405]; smoothened signaling pathway [GO:0007224]; sperm axoneme assembly [GO:0007288]; spermatid nucleus elongation [GO:0007290]; spinal cord dorsal/ventral patterning [GO:0021513]; telencephalon development [GO:0021537]	kinesin binding [GO:0019894]	acrosomal membrane [GO:0002080]; axonemal basal plate [GO:0097541]; axoneme [GO:0005930]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; intraciliary transport particle B [GO:0030992]; kinocilium [GO:0060091]; manchette [GO:0002177]; microtubule cytoskeleton [GO:0015630]; mitotic spindle [GO:0072686]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; nucleolus [GO:0005730]; outer acrosomal membrane [GO:0002081]; photoreceptor connecting cilium [GO:0032391]; sperm end piece [GO:0097229]; sperm flagellum [GO:0036126]; sperm head-tail coupling apparatus [GO:0120212]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]; trans-Golgi network [GO:0005802]	GO:0001654; GO:0001822; GO:0001886; GO:0001889; GO:0002080; GO:0002081; GO:0002177; GO:0003341; GO:0005730; GO:0005737; GO:0005802; GO:0005813; GO:0005814; GO:0005829; GO:0005929; GO:0005930; GO:0007219; GO:0007224; GO:0007288; GO:0007290; GO:0007368; GO:0007399; GO:0007420; GO:0007507; GO:0008104; GO:0008544; GO:0009887; GO:0009952; GO:0009953; GO:0015630; GO:0019894; GO:0021513; GO:0021537; GO:0030324; GO:0030900; GO:0030992; GO:0031016; GO:0031122; GO:0031514; GO:0032391; GO:0034405; GO:0034451; GO:0035720; GO:0036064; GO:0036126; GO:0036334; GO:0042073; GO:0042487; GO:0042733; GO:0043568; GO:0045171; GO:0045598; GO:0045724; GO:0048853; GO:0050680; GO:0055007; GO:0060091; GO:0060122; GO:0060173; GO:0060259; GO:0060271; GO:0060411; GO:0060426; GO:0060914; GO:0061351; GO:0070613; GO:0072686; GO:0090102; GO:0097225; GO:0097228; GO:0097229; GO:0097541; GO:0097542; GO:0097546; GO:0097730; GO:0120212; GO:1902017; GO:1903929; GO:1905515; GO:2000785
GN015216	GN015216.1	O62640	31.9	357	315	358	3.72e-53	181	PIAP_PIG	Putative inhibitor of apoptosis	Sus scrofa (Pig)	negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; regulation of cell cycle [GO:0051726]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0031398; GO:0033209; GO:0043027; GO:0043066; GO:0043123; GO:0051726; GO:0060546; GO:0061630
GN015218	GN015218.1	A1L1W9	30.4	434	637	505	1.22e-62	219	MOT10_DANRE	Monocarboxylate transporter 10 (MCT 10) (Solute carrier family 16 member 10)	Danio rerio (Zebrafish) (Brachydanio rerio)	aromatic amino acid transport [GO:0015801]; thyroid hormone transport [GO:0070327]	aromatic amino acid transmembrane transporter activity [GO:0015173]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-tryptophan transmembrane transporter activity [GO:0015196]; L-tyrosine transmembrane transporter activity [GO:0005302]; thyroid hormone transmembrane transporter activity [GO:0015349]; transmembrane transporter activity [GO:0022857]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005302; GO:0005886; GO:0015173; GO:0015192; GO:0015196; GO:0015349; GO:0015801; GO:0016323; GO:0022857; GO:0070327
GN015219	GN015219.1	Q92734	50.9	224	481	400	4.10e-50	179	TFG_HUMAN	Protein TFG (TRK-fused gene protein)	Homo sapiens (Human)	COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]	GO:0005737; GO:0005783; GO:0005829; GO:0006888; GO:0042802; GO:0043123; GO:0048208; GO:0070971
GN015220	GN015220.1	Q9BDY8	40.9	257	443	498	2.53e-52	186	ANGP1_PIG	Angiopoietin-1 (ANG-1)	Sus scrofa (Pig)	angiogenesis [GO:0001525]; blood coagulation [GO:0007596]; negative regulation of apoptotic process [GO:0043066]; Tie signaling pathway [GO:0048014]	receptor tyrosine kinase binding [GO:0030971]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0001525; GO:0005576; GO:0007596; GO:0030971; GO:0031012; GO:0043066; GO:0048014
GN015222	GN015222.1	V5NAL9	27.4	879	876	899	4.72e-101	338	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN015223	GN015223.1	Q6P0U3	38.8	178	235	244	1.14e-34	127	RSLBB_DANRE	Ras-like protein family member 11B (EC 3.6.5.2)	Danio rerio (Zebrafish) (Brachydanio rerio)	mesendoderm development [GO:0048382]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]		GO:0003924; GO:0003925; GO:0005525; GO:0048382
GN015225	GN015225.1	O62640	28.5	382	388	358	3.47e-43	157	PIAP_PIG	Putative inhibitor of apoptosis	Sus scrofa (Pig)	negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; regulation of cell cycle [GO:0051726]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0031398; GO:0033209; GO:0043027; GO:0043066; GO:0043123; GO:0051726; GO:0060546; GO:0061630
GN015229	GN015229.1	P83425	31.3	131	172	213	3.91e-13	67.8	HIP_MYTED	Heavy metal-binding protein HIP	Mytilus edulis (Blue mussel)			extracellular region [GO:0005576]	GO:0005576
GN015230	GN015230.1	Q6GL42	40.2	368	430	488	3.15e-78	253	TM39A_XENTR	Transmembrane protein 39A	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	negative regulation of autophagosome assembly [GO:1902902]; negative regulation of autophagosome maturation [GO:1901097]		endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:1901097; GO:1902902
GN015231	GN015231.1	Q7ZWY2	48.0	298	299	297	5.22e-97	290	PIHD1_XENLA	PIH1 domain-containing protein 1	Xenopus laevis (African clawed frog)	box C/D snoRNP assembly [GO:0000492]; rRNA processing [GO:0006364]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]	GO:0000492; GO:0005634; GO:0005737; GO:0006364; GO:0097255; GO:1990904
GN015234	GN015234.1	Q32LP2	63.4	587	560	583	3.87e-207	592	RADI_BOVIN	Radixin	Bos taurus (Bovine)	positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein localization to early endosome [GO:1902966]; regulation of cell shape [GO:0008360]; regulation of organelle assembly [GO:1902115]	actin binding [GO:0003779]; cell adhesion molecule binding [GO:0050839]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; cleavage furrow [GO:0032154]; filopodium [GO:0030175]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; stereocilium base [GO:0120044]	GO:0003779; GO:0005886; GO:0005902; GO:0005912; GO:0008360; GO:0030175; GO:0032154; GO:0045177; GO:0050839; GO:0120044; GO:1902115; GO:1902966; GO:2000643
GN015235	GN015235.1	Q4KLT6	51.5	235	406	393	1.20e-64	214	FL2D_XENLA	Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (WT1-associated protein) (Wilms tumor 1-associating protein)	Xenopus laevis (African clawed frog)	mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]		cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	GO:0000381; GO:0005634; GO:0005737; GO:0006397; GO:0016556; GO:0016607; GO:0036396
GN015236	GN015236.1	P04179	68.0	197	202	222	3.97e-102	296	SODM_HUMAN	Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)	Homo sapiens (Human)	acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure [GO:0003069]; cellular response to ethanol [GO:0071361]; cellular response to oxidative stress [GO:0034599]; hydrogen peroxide biosynthetic process [GO:0050665]; intracellular oxygen homeostasis [GO:0032364]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of membrane hyperpolarization [GO:1902631]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of cell migration [GO:0030335]; positive regulation of hydrogen peroxide biosynthetic process [GO:0010729]; positive regulation of phenotypic switching [GO:1900241]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; protein homotetramerization [GO:0051289]; regulation of blood pressure [GO:0008217]; regulation of transcription by RNA polymerase II [GO:0006357]; release of cytochrome c from mitochondria [GO:0001836]; removal of superoxide radicals [GO:0019430]; response to activity [GO:0014823]; response to cadmium ion [GO:0046686]; response to electrical stimulus [GO:0051602]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to isolation stress [GO:0035900]; response to L-ascorbic acid [GO:0033591]; response to lipopolysaccharide [GO:0032496]; response to magnetism [GO:0071000]; response to manganese ion [GO:0010042]; response to selenium ion [GO:0010269]; response to silicon dioxide [GO:0034021]; response to superoxide [GO:0000303]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; superoxide metabolic process [GO:0006801]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; oxygen binding [GO:0019825]; superoxide dismutase activity [GO:0004784]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	GO:0000303; GO:0001666; GO:0001836; GO:0003069; GO:0003677; GO:0004784; GO:0005739; GO:0005759; GO:0006357; GO:0006801; GO:0008217; GO:0008285; GO:0009410; GO:0010042; GO:0010043; GO:0010269; GO:0010729; GO:0014823; GO:0019430; GO:0019825; GO:0019899; GO:0030145; GO:0030335; GO:0032364; GO:0032496; GO:0033591; GO:0034021; GO:0034599; GO:0035900; GO:0035902; GO:0042542; GO:0042645; GO:0042802; GO:0043524; GO:0046686; GO:0050665; GO:0051289; GO:0051602; GO:0070062; GO:0071000; GO:0071361; GO:1900241; GO:1902176; GO:1902631; GO:1904706; GO:1905065; GO:1905461
GN015241	GN015241.1	Q5RF32	34.2	348	352	363	2.49e-47	167	BHMT2_PONAB	S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	L-methionine salvage [GO:0071267]	S-methylmethionine-homocysteine S-methyltransferase activity [GO:0061627]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]	GO:0005829; GO:0008270; GO:0061627; GO:0071267
GN015242	GN015242.1	P83425	31.5	130	172	213	6.97e-09	56.2	HIP_MYTED	Heavy metal-binding protein HIP	Mytilus edulis (Blue mussel)			extracellular region [GO:0005576]	GO:0005576
GN015243	GN015243.1	P83425	33.1	136	172	213	3.89e-11	62.4	HIP_MYTED	Heavy metal-binding protein HIP	Mytilus edulis (Blue mussel)			extracellular region [GO:0005576]	GO:0005576
GN015244	GN015244.1	Q5RF32	36.2	152	166	363	6.26e-13	68.6	BHMT2_PONAB	S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	L-methionine salvage [GO:0071267]	S-methylmethionine-homocysteine S-methyltransferase activity [GO:0061627]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]	GO:0005829; GO:0008270; GO:0061627; GO:0071267
GN015245	GN015245.1	Q54L00	32.9	213	557	650	1.89e-15	83.2	LIMKA_DICDI	Probable LIM domain-containing serine/threonine-protein kinase DDB_G0287001 (EC 2.7.11.1)	Dictyostelium discoideum (Social amoeba)		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]		GO:0004674; GO:0005524; GO:0106310
GN015246	GN015246.1	Q9BXJ4	34.1	132	172	246	1.13e-11	64.3	C1QT3_HUMAN	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	Homo sapiens (Human)	fat cell differentiation [GO:0045444]; intracellular triglyceride homeostasis [GO:0035356]; maintenance of synapse structure [GO:0099558]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001819; GO:0010629; GO:0016020; GO:0032715; GO:0032991; GO:0035356; GO:0042802; GO:0043083; GO:0045202; GO:0045444; GO:0045721; GO:0050728; GO:0070062; GO:0070165; GO:0071638; GO:0099550; GO:0099558; GO:1901223
GN015247	GN015247.1	Q5RF32	33.7	347	352	363	1.02e-45	162	BHMT2_PONAB	S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	L-methionine salvage [GO:0071267]	S-methylmethionine-homocysteine S-methyltransferase activity [GO:0061627]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]	GO:0005829; GO:0008270; GO:0061627; GO:0071267
GN015249	GN015249.1	P83425	29.5	132	172	213	1.98e-10	60.5	HIP_MYTED	Heavy metal-binding protein HIP	Mytilus edulis (Blue mussel)			extracellular region [GO:0005576]	GO:0005576
GN015250	GN015250.1	O01700	32.0	175	555	928	2.96e-14	79.7	DLK1_CAEEL	Mitogen-activated protein kinase kinase kinase dlk-1 (EC 2.7.11.25) (DAP kinase-like kinase) (Death-associated protein kinase-like kinase)	Caenorhabditis elegans	axon extension involved in regeneration [GO:0048677]; axon regeneration [GO:0031103]; formation of growth cone in injured axon [GO:0048689]; MAPK cascade [GO:0000165]; microtubule polymerization [GO:0046785]; p38MAPK cascade [GO:0038066]; positive regulation of axon extension [GO:0045773]; positive regulation of axon extension involved in regeneration [GO:0048691]; regulation of 3'-UTR-mediated mRNA stabilization [GO:1905868]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of synapse organization [GO:0050807]	ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; protein serine kinase activity [GO:0106310]; ubiquitin protein ligase binding [GO:0031625]	axon [GO:0030424]; cilium [GO:0005929]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; synapse [GO:0045202]	GO:0000165; GO:0004709; GO:0005524; GO:0005737; GO:0005929; GO:0030424; GO:0030425; GO:0031103; GO:0031625; GO:0038066; GO:0043025; GO:0045202; GO:0045773; GO:0046785; GO:0048677; GO:0048689; GO:0048691; GO:0048841; GO:0050807; GO:0106310; GO:1905868
GN015252	GN015252.1	P0C6R2	38.0	871	878	865	4.56e-173	526	ARMC2_BOVIN	Armadillo repeat-containing protein 2	Bos taurus (Bovine)	cilium organization [GO:0044782]; sperm axoneme assembly [GO:0007288]			GO:0007288; GO:0044782
GN015253	GN015253.1	P18172	37.3	327	330	625	4.99e-57	197	DHGL_DROPS	Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]	Drosophila pseudoobscura pseudoobscura (Fruit fly)		flavin adenine dinucleotide binding [GO:0050660]; glucose dehydrogenase (FAD, quinone) activity [GO:0140762]	extracellular region [GO:0005576]	GO:0005576; GO:0050660; GO:0140762
GN015255	GN015255.1	P18172	39.5	593	597	625	2.54e-116	362	DHGL_DROPS	Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]	Drosophila pseudoobscura pseudoobscura (Fruit fly)		flavin adenine dinucleotide binding [GO:0050660]; glucose dehydrogenase (FAD, quinone) activity [GO:0140762]	extracellular region [GO:0005576]	GO:0005576; GO:0050660; GO:0140762
GN015256	GN015256.1	P18173	40.4	166	206	612	1.81e-33	129	DHGL_DROME	Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]	Drosophila melanogaster (Fruit fly)	glucose metabolic process [GO:0006006]; pupal chitin-based cuticle development [GO:0008364]; sperm storage [GO:0046693]	flavin adenine dinucleotide binding [GO:0050660]; glucose dehydrogenase (FAD, quinone) activity [GO:0140762]; oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0006006; GO:0008364; GO:0016491; GO:0046693; GO:0050660; GO:0140762
GN015257	GN015257.1	P18172	39.4	579	926	625	3.17e-116	372	DHGL_DROPS	Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]	Drosophila pseudoobscura pseudoobscura (Fruit fly)		flavin adenine dinucleotide binding [GO:0050660]; glucose dehydrogenase (FAD, quinone) activity [GO:0140762]	extracellular region [GO:0005576]	GO:0005576; GO:0050660; GO:0140762
GN015263	GN015263.1	P83425	31.3	131	182	213	1.72e-09	58.2	HIP_MYTED	Heavy metal-binding protein HIP	Mytilus edulis (Blue mussel)			extracellular region [GO:0005576]	GO:0005576
GN015270	GN015270.1	Q67XQ0	43.9	412	432	494	5.66e-92	289	Y4424_ARATH	DUF21 domain-containing protein At4g14240 (CBS domain-containing protein CBSDUF1)	Arabidopsis thaliana (Mouse-ear cress)	magnesium ion homeostasis [GO:0010960]; regulation of stomatal opening [GO:1902456]	magnesium ion binding [GO:0000287]; transmembrane transporter activity [GO:0022857]	plant-type vacuole membrane [GO:0009705]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]	GO:0000287; GO:0005774; GO:0005886; GO:0009705; GO:0010960; GO:0022857; GO:1902456
GN015272	GN015272.1	Q2V897	34.6	133	509	784	1.15e-09	64.7	TLR2_BOSTR	Toll-like receptor 2 (CD antigen CD282)	Boselaphus tragocamelus (Nilgai)	cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; immune response [GO:0006955]; inflammatory response [GO:0006954]; toll-like receptor signaling pathway [GO:0002224]	transmembrane signaling receptor activity [GO:0004888]; triacyl lipopeptide binding [GO:0042497]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0002224; GO:0004888; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0016020; GO:0030670; GO:0042497; GO:0043235; GO:0045121; GO:0071726; GO:0071727
GN015274	GN015274.1	Q6Q759	32.0	2383	2270	2223	2.75e-259	832	SPG17_HUMAN	Sperm-associated antigen 17 (Projection protein PF6 homolog)	Homo sapiens (Human)	axonemal central apparatus assembly [GO:1904158]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; intramanchette transport [GO:1990953]; manchette assembly [GO:1905198]; motile cilium assembly [GO:0044458]; spermatogenesis [GO:0007283]		acrosomal vesicle [GO:0001669]; axonemal central apparatus [GO:1990716]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; manchette [GO:0002177]	GO:0001669; GO:0002177; GO:0003351; GO:0005576; GO:0005737; GO:0005794; GO:0007283; GO:0044458; GO:1904158; GO:1905198; GO:1990716; GO:1990953
GN015275	GN015275.1	Q28GQ2	52.0	346	351	350	3.08e-117	346	MECR_XENTR	Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC 1.3.1.104) (2-enoyl thioester reductase)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	pronephric nephron tubule development [GO:0039020]	enoyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0141148]	mitochondrion [GO:0005739]	GO:0005739; GO:0039020; GO:0141148
GN015276	GN015276.1	Q8BHW2	57.2	390	381	379	2.60e-138	402	OSCP1_MOUSE	Protein OSCP1	Mus musculus (Mouse)	xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	transmembrane transporter activity [GO:0022857]	basal plasma membrane [GO:0009925]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0009925; GO:0022857; GO:1990961
GN015277	GN015277.1	Q9NYL5	41.1	202	277	469	2.87e-45	161	CP39A_HUMAN	24-hydroxycholesterol 7-alpha-hydroxylase (EC 1.14.14.26) (Cytochrome P450 39A1) (hCYP39A1) (Oxysterol 7-alpha-hydroxylase)	Homo sapiens (Human)	bile acid biosynthetic process [GO:0006699]; cholesterol catabolic process [GO:0006707]; cholesterol homeostasis [GO:0042632]; digestion [GO:0007586]; sterol metabolic process [GO:0016125]	24S-hydroxycholesterol 7-alpha-hydroxylase activity [GO:0033782]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxysterol 7-alpha-hydroxylase activity [GO:0008396]; steroid hydroxylase activity [GO:0008395]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	GO:0005506; GO:0005789; GO:0006699; GO:0006707; GO:0007586; GO:0008395; GO:0008396; GO:0016125; GO:0020037; GO:0033782; GO:0042632; GO:0043231
GN015282	GN015282.1	Q8C8M1	34.9	146	215	221	1.18e-13	70.5	SHCAF_MOUSE	SIN3-HDAC complex-associated factor (Protein FAM60A) (Tera protein)	Mus musculus (Mouse)	negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of stem cell population maintenance [GO:1902459]		nucleus [GO:0005634]; Sin3-type complex [GO:0070822]	GO:0000122; GO:0005634; GO:0008284; GO:0030336; GO:0030512; GO:0045596; GO:0070822; GO:1902455; GO:1902459
GN015283	GN015283.1	Q93034	76.5	762	761	780	0.0	1162	CUL5_HUMAN	Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)	Homo sapiens (Human)	cell migration [GO:0016477]; ERBB2 signaling pathway [GO:0038128]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of focal adhesion disassembly [GO:0120184]; positive regulation of cell migration [GO:0030335]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; reelin-mediated signaling pathway [GO:0038026]; regulation of neuron migration [GO:2001222]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	calcium channel activity [GO:0005262]; signaling receptor activity [GO:0038023]; ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	Cul5-RING ubiquitin ligase complex [GO:0031466]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; site of DNA damage [GO:0090734]	GO:0000082; GO:0004842; GO:0005262; GO:0005634; GO:0005737; GO:0005829; GO:0016477; GO:0016567; GO:0019005; GO:0030335; GO:0031146; GO:0031466; GO:0031625; GO:0038023; GO:0038026; GO:0038128; GO:0043161; GO:0051895; GO:0070979; GO:0090734; GO:0097193; GO:0120184; GO:0160072; GO:2001222
GN015284	GN015284.1	P61759	62.7	153	250	196	2.62e-63	199	PFD3_MOUSE	Prefoldin subunit 3 (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1)	Mus musculus (Mouse)	negative regulation of amyloid fibril formation [GO:1905907]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]	amyloid-beta binding [GO:0001540]; tubulin binding [GO:0015631]; unfolded protein holdase activity [GO:0140309]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]	GO:0001540; GO:0005634; GO:0005737; GO:0005829; GO:0006457; GO:0007021; GO:0015631; GO:0016272; GO:0140309; GO:1905907
GN015292	GN015292.1	O15973	30.5	200	423	499	1.12e-21	100	OPSD1_MIZYE	Rhodopsin, GQ-coupled (GQ-rhodopsin)	Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis)	visual perception [GO:0007601]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007601
GN015295	GN015295.1	Q8JHV9	32.7	388	816	401	2.31e-51	188	BIR7A_XENLA	Baculoviral IAP repeat-containing protein 7-A (EC 2.3.2.27) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (RING-type E3 ubiquitin transferase EIAP-A) (XIAP homolog XLX) (XLX)	Xenopus laevis (African clawed frog)	negative regulation of apoptotic process [GO:0043066]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; regulation of cell cycle [GO:0051726]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004869; GO:0005634; GO:0005737; GO:0031398; GO:0043027; GO:0043066; GO:0051726; GO:0051865; GO:0061630
GN015296	GN015296.1	A4IFD0	50.0	56	117	562	9.73e-12	63.5	KAD5_BOVIN	Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5)	Bos taurus (Bovine)	ATP metabolic process [GO:0046034]	AMP kinase activity [GO:0004017]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004017; GO:0004550; GO:0005524; GO:0005737; GO:0005829; GO:0046034
GN015297	GN015297.1	P32939	30.7	150	475	208	5.93e-15	77.0	YPT7_YEAST	Ypt/Rab-type GTPase YPT7 (Ypt7p) (Vacuolar morphology protein 4)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	cytoplasm to vacuole targeting by the Cvt pathway [GO:0032258]; endocytosis [GO:0006897]; macroautophagy [GO:0016236]; piecemeal microautophagy of the nucleus [GO:0034727]; protein localization to vacuole [GO:0072665]; regulation of protein-containing complex assembly [GO:0043254]; regulation of vacuole fusion, non-autophagic [GO:0032889]; retrograde transport, endosome to Golgi [GO:0042147]; vacuole inheritance [GO:0000011]; vesicle-mediated transport [GO:0016192]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-containing complex binding [GO:0044877]	cytosol [GO:0005829]; fungal-type vacuole [GO:0000324]; fungal-type vacuole membrane [GO:0000329]; late endosome [GO:0005770]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body [GO:0005771]; phagocytic vesicle [GO:0045335]; vacuolar membrane [GO:0005774]; vacuole [GO:0005773]; vacuole-mitochondrion membrane contact site [GO:1990816]	GO:0000011; GO:0000324; GO:0000329; GO:0003924; GO:0005525; GO:0005739; GO:0005741; GO:0005770; GO:0005771; GO:0005773; GO:0005774; GO:0005829; GO:0006897; GO:0016192; GO:0016236; GO:0032258; GO:0032889; GO:0034727; GO:0042147; GO:0043254; GO:0044877; GO:0045335; GO:0072665; GO:1990816
GN015298	GN015298.1	W6YKT9	30.8	169	748	644	2.00e-09	64.7	PGH_COCC2	Polyglycine hydrolase (EC 3.4.21.-) (Chitinase modifying protein) (BzCMP)	Cochliobolus carbonum (strain 26-R-13) (Maize leaf spot fungus) (Bipolaris zeicola)	effector-mediated suppression of host defense response [GO:0140590]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]	GO:0004252; GO:0005576; GO:0140590
GN015299	GN015299.1	Q6G6M9	24.3	222	785	498	4.63e-11	69.7	FLP_STAAS	Protein flp (FmtA-like protein)	Staphylococcus aureus (strain MSSA476)			plasma membrane [GO:0005886]	GO:0005886
GN015302	GN015302.1	O94822	32.3	1784	1729	1766	5.04e-303	920	LTN1_HUMAN	E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294)	Homo sapiens (Human)	protein autoubiquitination [GO:0051865]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	ribosomal large subunit binding [GO:0043023]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; RQC complex [GO:1990112]	GO:0005829; GO:0008270; GO:0022626; GO:0043023; GO:0051865; GO:0061630; GO:0072344; GO:1990112; GO:1990116
GN015307	GN015307.1	O08863	26.6	578	476	600	4.13e-48	177	BIRC3_MOUSE	Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 2) (C-IAP2) (Inhibitor of apoptosis protein 1) (mIAP1) (RING-type E3 ubiquitin transferase BIRC3)	Mus musculus (Mouse)	cellular response to tumor necrosis factor [GO:0071356]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; negative regulation of phosphorylation [GO:0042326]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of necroptotic process [GO:0060544]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; protein-containing complex binding [GO:0044877]; transferase activity [GO:0016740]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0016740; GO:0031398; GO:0032991; GO:0042326; GO:0042981; GO:0043027; GO:0043066; GO:0044877; GO:0051726; GO:0060544; GO:0060546; GO:0061630; GO:0070266; GO:0071356; GO:1901222; GO:1902916; GO:2000378
GN015308	GN015308.1	A9ULZ2	29.7	431	522	345	1.79e-50	179	BIR7B_XENLA	Baculoviral IAP repeat-containing protein 7-B (EC 2.3.2.27) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) (RING-type E3 ubiquitin transferase EIAP-B)	Xenopus laevis (African clawed frog)	negative regulation of apoptotic process [GO:0043066]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; regulation of cell cycle [GO:0051726]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004869; GO:0005634; GO:0005737; GO:0031398; GO:0043027; GO:0043066; GO:0051726; GO:0051865; GO:0061630
GN015310	GN015310.1	Q13489	40.0	90	398	604	4.47e-12	71.2	BIRC3_HUMAN	Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)	Homo sapiens (Human)	canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; spermatogenesis [GO:0007283]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; protein-containing complex binding [GO:0044877]; transferase activity [GO:0016740]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; tumor necrosis factor receptor superfamily complex [GO:0002947]	GO:0002947; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006954; GO:0007166; GO:0007249; GO:0007283; GO:0008625; GO:0008630; GO:0016740; GO:0031398; GO:0033209; GO:0034121; GO:0038061; GO:0039535; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0044877; GO:0045088; GO:0050727; GO:0051726; GO:0060544; GO:0060546; GO:0061630; GO:0070424
GN015316	GN015316.1	Q9UNX4	62.5	938	927	943	1.76e-186	565	WDR3_HUMAN	WD repeat-containing protein 3	Homo sapiens (Human)	maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]	RNA binding [GO:0003723]; snoRNA binding [GO:0030515]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]	GO:0003723; GO:0005654; GO:0005730; GO:0030490; GO:0030515; GO:0032040; GO:0034388; GO:0042274
GN015324	GN015324.1	Q8C8H8	26.3	521	518	661	4.24e-44	168	KY_MOUSE	Kyphoscoliosis peptidase (EC 3.4.-.-)	Mus musculus (Mouse)	muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]	GO:0005737; GO:0005856; GO:0007517; GO:0007528; GO:0030018
GN015330	GN015330.1	A0A2B4RP11	29.5	227	600	376	7.24e-17	86.3	CGLR1_STYPI	Cyclic GMP-AMP synthase-like receptor 1 (Sp-cGLR1) (Cyclic UMP-AMP synthase cGLR1) (EC 2.7.7.-)	Stylophora pistillata (Smooth cauliflower coral)		double-stranded RNA binding [GO:0003725]; nucleotidyltransferase activity [GO:0016779]		GO:0003725; GO:0016779
GN015333	GN015333.1	Q3SYU2	62.4	844	830	858	0.0	1068	EF2_BOVIN	Elongation factor 2 (EF-2) (EC 3.6.5.-)	Bos taurus (Bovine)	positive regulation of translation [GO:0045727]; translational elongation [GO:0006414]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; lncRNA binding [GO:0106222]; protein kinase binding [GO:0019901]; ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; synapse [GO:0045202]	GO:0003746; GO:0003924; GO:0005525; GO:0005634; GO:0005737; GO:0005829; GO:0005840; GO:0006414; GO:0019901; GO:0043022; GO:0045202; GO:0045727; GO:0106222; GO:1990904
GN015334	GN015334.1	P17971	33.7	104	161	571	5.08e-09	57.4	KCNAL_DROME	Potassium voltage-gated channel protein Shal (Shaker cognate l) (Shal2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]	A-type (transient outward) potassium channel activity [GO:0005250]; voltage-gated potassium channel activity [GO:0005249]	dendrite [GO:0030425]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005250; GO:0005886; GO:0006813; GO:0007268; GO:0008076; GO:0008306; GO:0016020; GO:0030425; GO:0043204; GO:0045202; GO:0051260; GO:0071805
GN015335	GN015335.1	P17971	28.8	153	172	571	1.07e-09	59.7	KCNAL_DROME	Potassium voltage-gated channel protein Shal (Shaker cognate l) (Shal2)	Drosophila melanogaster (Fruit fly)	action potential [GO:0001508]; associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]	A-type (transient outward) potassium channel activity [GO:0005250]; voltage-gated potassium channel activity [GO:0005249]	dendrite [GO:0030425]; membrane [GO:0016020]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]	GO:0001508; GO:0005249; GO:0005250; GO:0005886; GO:0006813; GO:0007268; GO:0008076; GO:0008306; GO:0016020; GO:0030425; GO:0043204; GO:0045202; GO:0051260; GO:0071805
GN015337	GN015337.1	D3YXG0	43.4	136	202	5634	4.23e-27	111	HMCN1_MOUSE	Hemicentin-1 (Fibulin-6) (FIBL-6)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]; response to bacterium [GO:0009617]	calcium ion binding [GO:0005509]; cell adhesion mediator activity [GO:0098631]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; muscle tendon junction [GO:0005927]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005509; GO:0005576; GO:0005604; GO:0005737; GO:0005886; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0009617; GO:0030036; GO:0030054; GO:0031012; GO:0032154; GO:0070161; GO:0071711; GO:0098631; GO:0140144
GN015338	GN015338.1	Q924X7	53.9	308	416	491	1.43e-108	331	STK33_MOUSE	Serine/threonine-protein kinase 33 (EC 2.7.11.1)	Mus musculus (Mouse)	manchette assembly [GO:1905198]; mitotic DNA damage checkpoint signaling [GO:0044773]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein polyubiquitination [GO:1902915]; protein autophosphorylation [GO:0046777]; spermatogenesis [GO:0007283]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; manchette [GO:0002177]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0002177; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0007283; GO:0032435; GO:0044773; GO:0046777; GO:0048471; GO:0106310; GO:1902915; GO:1905198
GN015343	GN015343.1	Q95KD7	31.7	470	977	935	2.76e-29	129	CC191_MACFA	Coiled-coil domain-containing protein 191	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)				
GN015344	GN015344.1	Q1JQD7	67.2	329	384	633	3.39e-162	472	MOCS1_BOVIN	Molybdenum cofactor biosynthesis protein 1 [Includes: GTP 3',8-cyclase (EC 4.1.99.22) (MOCS1A) (Molybdenum cofactor biosynthesis protein A); Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (MOCS1B) (Molybdenum cofactor biosynthesis protein C)]	Bos taurus (Bovine)	Mo-molybdopterin cofactor biosynthetic process [GO:0006777]	4 iron, 4 sulfur cluster binding [GO:0051539]; cyclic pyranopterin monophosphate synthase activity [GO:0061799]; GTP 3',8'-cyclase activity [GO:0061798]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]	GO:0005759; GO:0005829; GO:0006777; GO:0046872; GO:0051539; GO:0061798; GO:0061799
GN015346	GN015346.1	Q6TLH3	31.0	226	243	282	2.20e-24	101	CUED2_DANRE	CUE domain-containing protein 2	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN015347	GN015347.1	P40927	61.1	553	608	557	5.87e-247	694	MAOX_COLLI	NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40)	Columba livia (Rock dove)	malate metabolic process [GO:0006108]	malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; NAD binding [GO:0051287]; oxaloacetate decarboxylase activity [GO:0008948]	mitochondrion [GO:0005739]	GO:0004473; GO:0005739; GO:0006108; GO:0008948; GO:0051287
GN015350	GN015350.1	Q65YR8	44.8	96	119	94	3.48e-18	76.3	CYTA1_DICDI	Cystatin-A1	Dictyostelium discoideum (Social amoeba)	adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway [GO:0140582]; regulation of proteolysis [GO:0030162]; response to bacterium [GO:0009617]	cysteine-type endopeptidase inhibitor activity [GO:0004869]	cytosol [GO:0005829]; phagocytic vesicle [GO:0045335]; vesicle [GO:0031982]	GO:0004869; GO:0005829; GO:0009617; GO:0030162; GO:0031982; GO:0045335; GO:0140582
GN015355	GN015355.1	Q6EE31	68.6	545	544	548	5.89e-276	764	TCPQ_CHICK	T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta)	Gallus gallus (Chicken)	protein folding [GO:0006457]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]	centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]	GO:0005524; GO:0005737; GO:0005813; GO:0005832; GO:0006457; GO:0016887; GO:0140662
GN015356	GN015356.1	Q5ZMR9	47.5	1140	1159	1154	0.0	1087	XPO4_CHICK	Exportin-4	Gallus gallus (Chicken)	protein export from nucleus [GO:0006611]	nuclear export signal receptor activity [GO:0005049]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]	GO:0005049; GO:0005643; GO:0005737; GO:0006611
GN015357	GN015357.1	Q17134	55.1	437	419	448	3.06e-146	426	TBXT1_BRAFL	T-box transcription factor T homolog 1 (AmBra-1) (Brachyury protein homolog 1)	Branchiostoma floridae (Florida lancelet) (Amphioxus)	cell fate specification [GO:0001708]; heart morphogenesis [GO:0003007]; mesoderm formation [GO:0001707]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001707; GO:0001708; GO:0003007; GO:0005634; GO:0006357; GO:0045893
GN015364	GN015364.1	A0A345BJN8	30.6	248	479	919	7.19e-25	112	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN015369	GN015369.1	A6NNY8	23.5	332	780	438	2.56e-09	63.9	UBP27_HUMAN	Ubiquitin carboxyl-terminal hydrolase 27 (EC 3.4.19.12) (Deubiquitinating enzyme 27) (Ubiquitin carboxyl-terminal hydrolase 22-like) (Ubiquitin thioesterase 27) (Ubiquitin-specific-processing protease 27) (X-linked ubiquitin carboxyl-terminal hydrolase 27)	Homo sapiens (Human)	defense response to virus [GO:0051607]; positive regulation of apoptotic process [GO:0043065]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004197; GO:0004843; GO:0005634; GO:0005829; GO:0016579; GO:0043065; GO:0050821; GO:0051607; GO:0060340; GO:0061578; GO:0070536; GO:0071108; GO:1990380
GN015370	GN015370.1	Q9P2Z0	38.6	88	314	257	5.31e-14	73.9	THA10_HUMAN	THAP domain-containing protein 10	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]		GO:0043565
GN015372	GN015372.1	Q9FPS2	27.1	325	615	661	4.52e-16	85.5	UBP25_ARATH	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (AtUBP25) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)	Arabidopsis thaliana (Mouse-ear cress)	protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]	nucleus [GO:0005634]	GO:0004843; GO:0005634; GO:0016579
GN015379	GN015379.1	Q9VEX9	62.0	150	152	150	1.07e-63	194	SAP18_DROME	Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (Bicoid-interacting protein 1) (dSAP18)	Drosophila melanogaster (Fruit fly)	heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]	DNA-binding transcription factor binding [GO:0140297]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003714; GO:0005634; GO:0005737; GO:0031507; GO:0045892; GO:0140297
GN015380	GN015380.1	P82596	38.9	72	97	155	4.01e-14	66.6	PLC_HALLA	Perlucin	Haliotis laevigata (Smooth Australian abalone)				
GN015381	GN015381.1	Q8BUL5	22.9	245	448	586	1.08e-11	70.5	KLHL7_MOUSE	Kelch-like protein 7	Mus musculus (Mouse)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0016567; GO:0031463; GO:0042802; GO:0042803; GO:0043161; GO:0048471; GO:1990756
GN015382	GN015382.1	Q8BUG5	35.6	511	726	550	4.30e-78	263	CAYP2_MOUSE	Calcyphosin-2 (Calcyphosine-2)	Mus musculus (Mouse)	brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cerebellum development [GO:0021549]; dendrite development [GO:0016358]; hippocampal interneuron differentiation [GO:0097410]; protein secretion [GO:0009306]; social behavior [GO:0035176]; synapse organization [GO:0050808]	calcium ion binding [GO:0005509]	parallel fiber [GO:1990032]; secretory vesicle [GO:0099503]	GO:0005509; GO:0009306; GO:0016358; GO:0021549; GO:0031547; GO:0035176; GO:0050808; GO:0097410; GO:0099503; GO:1990032
GN015383	GN015383.1	D5FM38	34.1	337	514	581	2.22e-53	192	NAS36_BRUMA	Zinc metalloproteinase nas-36 (EC 3.4.24.-) (Nematode astacin 36)	Brugia malayi (Filarial nematode worm)	molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0004222; GO:0005576; GO:0006508; GO:0008270; GO:0018996
GN015384	GN015384.1	Q21059	46.5	127	333	605	9.74e-25	108	NAS34_CAEEL	Zinc metalloproteinase nas-34 (EC 3.4.24.-) (Defective hatching protein 1) (Nematode astacin 34)	Caenorhabditis elegans	hatching [GO:0035188]; molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; neuron migration [GO:0001764]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0001764; GO:0004222; GO:0005576; GO:0006508; GO:0008270; GO:0018996; GO:0035188
GN015386	GN015386.1	Q18206	40.7	189	266	617	1.39e-39	148	NAS36_CAEEL	Zinc metalloproteinase nas-36 (EC 3.4.24.-) (Nematode astacin 36)	Caenorhabditis elegans	molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0004222; GO:0005576; GO:0006508; GO:0008270; GO:0018996
GN015391	GN015391.1	O53532	25.7	327	357	353	2.22e-25	108	Y2258_MYCTU	S-adenosylmethionine-dependent methyltransferase Rv2258c (EC 2.1.1.-)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	cellular response to hypoxia [GO:0071456]		plasma membrane [GO:0005886]	GO:0005886; GO:0071456
GN015394	GN015394.1	P82596	41.7	132	159	155	6.77e-28	104	PLC_HALLA	Perlucin	Haliotis laevigata (Smooth Australian abalone)				
GN015395	GN015395.1	O53532	25.5	349	345	353	5.19e-22	98.6	Y2258_MYCTU	S-adenosylmethionine-dependent methyltransferase Rv2258c (EC 2.1.1.-)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	cellular response to hypoxia [GO:0071456]		plasma membrane [GO:0005886]	GO:0005886; GO:0071456
GN015399	GN015399.1	O93530	30.9	343	373	1436	9.79e-37	145	WRN_XENLA	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Focus-forming activity 1) (FFA-1) (Werner syndrome protein homolog) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Xenopus laevis (African clawed frog)	DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; four-way junction helicase activity [GO:0009378]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000723; GO:0000724; GO:0000781; GO:0003676; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006259; GO:0006260; GO:0008408; GO:0009378; GO:0016887; GO:0030145; GO:0032392; GO:0043138
GN015404	GN015404.1	P82596	35.1	131	157	155	3.09e-19	82.0	PLC_HALLA	Perlucin	Haliotis laevigata (Smooth Australian abalone)				
GN015416	GN015416.1	P34456	27.4	223	224	419	7.26e-22	95.9	YMD2_CAEEL	Uncharacterized protein F54H12.2	Caenorhabditis elegans	deoxyribonucleotide biosynthetic process [GO:0009263]	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]	cytosol [GO:0005829]	GO:0004748; GO:0005829; GO:0009263
GN015425	GN015425.1	P23654	35.1	325	348	846	5.93e-52	187	NRT_DROME	Neurotactin	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; heterophilic cell-cell adhesion [GO:0007157]	cell adhesion receptor activity [GO:0004895]	axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004895; GO:0005737; GO:0005886; GO:0007157; GO:0007409; GO:0007411; GO:0007413; GO:0007417; GO:0016323; GO:0030424
GN015426	GN015426.1	P70665	39.7	522	501	541	7.57e-116	355	SIAE_MOUSE	Sialate O-acetylesterase (SIAE) (EC 3.1.1.53) (Sialic acid-specific 9-O-acetylesterase) (Yolk sac protein 2) [Cleaved into: Sialate O-acetylesterase small subunit; Sialate O-acetylesterase large subunit]	Mus musculus (Mouse)	carbohydrate metabolic process [GO:0005975]; regulation of immune system process [GO:0002682]	sialate 9-O-acetylesterase activity [GO:0106330]; sialate O-acetylesterase activity [GO:0001681]	lysosome [GO:0005764]	GO:0001681; GO:0002682; GO:0005764; GO:0005975; GO:0106330
GN015431	GN015431.1	P18293	33.8	133	217	1057	1.30e-12	69.7	ANPRA_MOUSE	Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)	Mus musculus (Mouse)	cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	ANPR-A receptor complex [GO:1990620]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005789; GO:0005886; GO:0006182; GO:0007166; GO:0007168; GO:0008217; GO:0016020; GO:0016941; GO:0017046; GO:0031965; GO:0035556; GO:0042417; GO:0042562; GO:0043114; GO:0043235; GO:0048662; GO:1990620
GN015433	GN015433.1	P83553	36.1	108	179	148	5.38e-18	79.3	DERM_BIOGL	Dermatopontin (Tyrosine-rich acidic matrix protein) (TRAMP)	Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail)	collagen fibril organization [GO:0030199]		extracellular matrix [GO:0031012]	GO:0030199; GO:0031012
GN015434	GN015434.1	P06280	51.7	302	346	429	2.02e-112	336	AGAL_HUMAN	Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Galactosylgalactosylglucosylceramidase GLA) (Melibiase) (Agalsidase)	Homo sapiens (Human)	glycoside catabolic process [GO:0016139]; glycosphingolipid catabolic process [GO:0046479]; glycosylceramide catabolic process [GO:0046477]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of nitric-oxide synthase activity [GO:0051001]; oligosaccharide metabolic process [GO:0009311]	alpha-galactosidase activity [GO:0004557]; catalytic activity [GO:0003824]; hydrolase activity [GO:0016787]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]	azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]	GO:0003824; GO:0004557; GO:0005102; GO:0005576; GO:0005737; GO:0005764; GO:0005794; GO:0009311; GO:0016139; GO:0016787; GO:0035578; GO:0042803; GO:0043202; GO:0045019; GO:0046477; GO:0046479; GO:0051001; GO:0070062
GN015435	GN015435.1	Q01528	39.8	123	154	172	3.20e-25	97.8	HAAF_LIMPO	Hemagglutinin/amebocyte aggregation factor (18K-LAF)	Limulus polyphemus (Atlantic horseshoe crab)	collagen fibril organization [GO:0030199]		extracellular matrix [GO:0031012]	GO:0030199; GO:0031012
GN015437	GN015437.1	Q6P3L0	44.6	879	849	863	1.33e-242	704	MVP_DANRE	Major vault protein (MVP)	Danio rerio (Zebrafish) (Brachydanio rerio)	brain development [GO:0007420]; cranial skeletal system development [GO:1904888]; eye development [GO:0001654]; neuron projection regeneration [GO:0031102]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001654; GO:0005634; GO:0005737; GO:0007420; GO:0031102; GO:1904888
GN015438	GN015438.1	O34355	25.0	428	448	529	9.62e-28	119	YTCJ_BACSU	Putative amidohydrolase YtcJ (EC 3.5.-.-)	Bacillus subtilis (strain 168)		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]		GO:0016810
GN015440	GN015440.1	O34355	24.5	568	632	529	4.73e-35	142	YTCJ_BACSU	Putative amidohydrolase YtcJ (EC 3.5.-.-)	Bacillus subtilis (strain 168)		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]		GO:0016810
GN015441	GN015441.1	Q498J9	41.3	201	466	233	2.75e-44	158	MBLC1_XENLA	Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1)	Xenopus laevis (African clawed frog)	histone mRNA metabolic process [GO:0008334]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0008334; GO:0046872; GO:1900087
GN015443	GN015443.1	P83425	32.3	130	182	213	9.56e-12	64.3	HIP_MYTED	Heavy metal-binding protein HIP	Mytilus edulis (Blue mussel)			extracellular region [GO:0005576]	GO:0005576
GN015447	GN015447.1	P83425	30.8	130	182	213	1.25e-09	58.5	HIP_MYTED	Heavy metal-binding protein HIP	Mytilus edulis (Blue mussel)			extracellular region [GO:0005576]	GO:0005576
GN015449	GN015449.1	P83425	31.3	131	182	213	1.29e-10	61.2	HIP_MYTED	Heavy metal-binding protein HIP	Mytilus edulis (Blue mussel)			extracellular region [GO:0005576]	GO:0005576
GN015450	GN015450.1	P83425	30.5	131	182	213	6.54e-10	59.3	HIP_MYTED	Heavy metal-binding protein HIP	Mytilus edulis (Blue mussel)			extracellular region [GO:0005576]	GO:0005576
GN015452	GN015452.1	P83425	33.1	130	182	213	1.34e-12	66.6	HIP_MYTED	Heavy metal-binding protein HIP	Mytilus edulis (Blue mussel)			extracellular region [GO:0005576]	GO:0005576
GN015462	GN015462.1	D3YXG0	45.3	75	210	5634	1.16e-17	84.3	HMCN1_MOUSE	Hemicentin-1 (Fibulin-6) (FIBL-6)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]; response to bacterium [GO:0009617]	calcium ion binding [GO:0005509]; cell adhesion mediator activity [GO:0098631]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; muscle tendon junction [GO:0005927]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005509; GO:0005576; GO:0005604; GO:0005737; GO:0005886; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0009617; GO:0030036; GO:0030054; GO:0031012; GO:0032154; GO:0070161; GO:0071711; GO:0098631; GO:0140144
GN015466	GN015466.1	Q7Z5L3	34.8	115	347	287	4.58e-11	66.2	C1QL2_HUMAN	Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; regulation of synapse maturation [GO:0090128]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0032991; GO:0042802; GO:0043083; GO:0045202; GO:0090128; GO:0097107; GO:0098686; GO:0099550; GO:0099558; GO:0099645; GO:0150053
GN015470	GN015470.1	P02746	31.3	134	380	253	1.96e-09	61.2	C1QB_HUMAN	Complement C1q subcomponent subunit B	Homo sapiens (Human)	complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; synapse pruning [GO:0098883]	IgG binding [GO:0019864]; IgM binding [GO:0001791]; phosphatidylserine binding [GO:0001786]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; complement component C1 complex [GO:0005602]; complement component C1q complex [GO:0062167]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; postsynapse [GO:0098794]; symbiont cell surface [GO:0106139]; synapse [GO:0045202]	GO:0001786; GO:0001791; GO:0005576; GO:0005602; GO:0006956; GO:0006958; GO:0009986; GO:0019864; GO:0031012; GO:0045202; GO:0062167; GO:0072562; GO:0098794; GO:0098883; GO:0106139
GN015472	GN015472.1	Q9FT72	27.4	310	372	713	2.38e-24	108	RQL3_ARATH	ATP-dependent DNA helicase Q-like 3 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ3) (RecQ-like protein 3) (AtRecQ3) (AtRecQl3)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA/DNA annealing activity [GO:1990814]; four-way junction helicase activity [GO:0009378]; helicase activity [GO:0004386]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004386; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006310; GO:0009378; GO:0016887; GO:0043138; GO:1990814
GN015477	GN015477.1	Q6DFR0	56.6	272	288	269	1.84e-90	272	TOLIP_XENTR	Toll-interacting protein	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	phosphorylation [GO:0016310]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]	GO:0005737; GO:0005768; GO:0005769; GO:0006511; GO:0016310; GO:0031624; GO:0043130
GN015480	GN015480.1	Q5RJ80	37.0	135	411	914	1.73e-09	63.5	CAPR2_DANRE	Caprin-2 (RNA granule protein 140)	Danio rerio (Zebrafish) (Brachydanio rerio)	dorsal/ventral axis specification [GO:0009950]; dorsal/ventral pattern formation [GO:0009953]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]	signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005102; GO:0005737; GO:0005886; GO:0009950; GO:0009953; GO:0030177; GO:0050775; GO:0061003; GO:0090263
GN015481	GN015481.1	A0A8M9Q308	54.8	434	506	485	1.69e-167	485	FLC2B_DANRE	Choline/ethanolamine transporter flvcr2b (Feline leukemia virus subgroup C receptor-related protein 2 homolog B) (Heme transporter flvcr2b) (Major facilitator superfamily domain containing 7C-b)	Danio rerio (Zebrafish) (Brachydanio rerio)	transport across blood-brain barrier [GO:0150104]	choline transmembrane transporter activity [GO:0015220]; ethanolamine transmembrane transporter activity [GO:0034228]	endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	GO:0005789; GO:0005886; GO:0015220; GO:0031966; GO:0034228; GO:0150104
GN015484	GN015484.1	A1L1W9	45.3	380	474	505	1.32e-105	326	MOT10_DANRE	Monocarboxylate transporter 10 (MCT 10) (Solute carrier family 16 member 10)	Danio rerio (Zebrafish) (Brachydanio rerio)	aromatic amino acid transport [GO:0015801]; thyroid hormone transport [GO:0070327]	aromatic amino acid transmembrane transporter activity [GO:0015173]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-tryptophan transmembrane transporter activity [GO:0015196]; L-tyrosine transmembrane transporter activity [GO:0005302]; thyroid hormone transmembrane transporter activity [GO:0015349]; transmembrane transporter activity [GO:0022857]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005302; GO:0005886; GO:0015173; GO:0015192; GO:0015196; GO:0015349; GO:0015801; GO:0016323; GO:0022857; GO:0070327
GN015488	GN015488.1	Q5R5H7	35.9	117	131	555	5.53e-16	76.3	S22A2_PONAB	Solute carrier family 22 member 2 (Organic cation transporter 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	acetylcholine transport [GO:0015870]; choline transport [GO:0015871]; dopamine uptake [GO:0090494]; histamine transport [GO:0051608]; prostaglandin transport [GO:0015732]; purine-containing compound transmembrane transport [GO:0072530]; putrescine transport [GO:0015847]; serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; thiamine transmembrane transport [GO:0071934]	acetylcholine transmembrane transporter activity [GO:0005277]; choline transmembrane transporter activity [GO:0015220]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; prostaglandin transmembrane transporter activity [GO:0015132]; putrescine transmembrane transporter activity [GO:0015489]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; spermidine transmembrane transporter activity [GO:0015606]; thiamine transmembrane transporter activity [GO:0015234]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; presynapse [GO:0098793]	GO:0005277; GO:0005326; GO:0008504; GO:0009925; GO:0015132; GO:0015220; GO:0015234; GO:0015489; GO:0015606; GO:0015651; GO:0015732; GO:0015847; GO:0015848; GO:0015870; GO:0015871; GO:0016323; GO:0016324; GO:0022857; GO:0042910; GO:0051608; GO:0051610; GO:0071934; GO:0072530; GO:0090494; GO:0098793
GN015489	GN015489.1	Q5UQ22	23.4	402	406	960	8.45e-16	83.2	YL207_MIMIV	Putative helicase L207/L206 (EC 3.6.4.-)	Acanthamoeba polyphaga mimivirus (APMV)		ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity, acting on acid anhydrides [GO:0016817]		GO:0004386; GO:0005524; GO:0016817
GN015491	GN015491.1	Q54KD0	25.1	239	421	1663	8.51e-15	80.5	Y7407_DICDI	TPR repeat-containing protein DDB_G0287407	Dictyostelium discoideum (Social amoeba)			Cul4-RING E3 ubiquitin ligase complex [GO:0080008]	GO:0080008
GN015493	GN015493.1	Q57YG0	27.7	364	539	992	2.19e-19	95.9	PIF7_TRYB2	ATP-dependent DNA helicase PIF7 (EC 5.6.2.3) (DNA 5'-3' helicase PIF7) (DNA repair and recombination helicase PIF7)	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	chromosome organization [GO:0051276]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; magnesium ion binding [GO:0000287]	kinetoplast [GO:0020023]; mitochondrion [GO:0005739]; nuclear lumen [GO:0031981]	GO:0000287; GO:0000723; GO:0005524; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0020023; GO:0031981; GO:0043139; GO:0051276
GN015494	GN015494.1	A0A2B4RNI3	29.5	241	703	688	1.18e-16	87.8	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN015495	GN015495.1	G3X987	28.0	193	256	291	3.29e-11	65.5	GIMA9_MOUSE	GTPase IMAP family member 9 (Immune-associated nucleotide-binding protein 7) (IAN-7) (Immunity-associated nucleotide-binding protein 7)	Mus musculus (Mouse)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]		GO:0003924; GO:0005525
GN015496	GN015496.1	G3X987	32.3	201	452	291	2.40e-23	102	GIMA9_MOUSE	GTPase IMAP family member 9 (Immune-associated nucleotide-binding protein 7) (IAN-7) (Immunity-associated nucleotide-binding protein 7)	Mus musculus (Mouse)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]		GO:0003924; GO:0005525
GN015501	GN015501.1	Q9NRJ4	44.8	201	261	1543	9.56e-41	152	TULP4_HUMAN	Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4)	Homo sapiens (Human)	protein ubiquitination [GO:0016567]		cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0016567
GN015503	GN015503.1	A1ZAX0	31.1	328	359	499	1.15e-50	179	CCH1R_DROME	Neuropeptide CCHamide-1 receptor	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	allatostatin receptor activity [GO:0008261]; neuropeptide receptor activity [GO:0008188]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0007218; GO:0008188; GO:0008261; GO:0016020
GN015505	GN015505.1	A1ZAX0	29.9	345	344	499	1.98e-51	181	CCH1R_DROME	Neuropeptide CCHamide-1 receptor	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	allatostatin receptor activity [GO:0008261]; neuropeptide receptor activity [GO:0008188]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0007218; GO:0008188; GO:0008261; GO:0016020
GN015506	GN015506.1	Q9GZN1	59.5	398	396	396	3.03e-186	525	ARP6_HUMAN	Actin-related protein 6 (hArp6) (hARPX)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase I [GO:0016479]; nucleolus organization [GO:0007000]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of DNA-templated transcription [GO:0006355]	nucleosome binding [GO:0031491]	cytoskeleton [GO:0005856]; nucleolus [GO:0005730]; nucleosome [GO:0000786]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]	GO:0000786; GO:0000812; GO:0005634; GO:0005730; GO:0005856; GO:0006338; GO:0006355; GO:0007000; GO:0016479; GO:0031491; GO:0045943
GN015507	GN015507.1	Q9CXG3	68.5	73	95	492	3.27e-24	97.8	PPIL4_MOUSE	Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4)	Mus musculus (Mouse)		peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0003723; GO:0003755; GO:0005654; GO:0005681; GO:0005829; GO:0071006
GN015508	GN015508.1	G5EEW6	63.9	72	76	427	1.59e-27	105	SIG7_CAEEL	Peptidyl-prolyl cis-trans isomerase sig-7 (EC 5.2.1.8) (Cyclophilin-like protein sig-7) (Silencer in germline 7)	Caenorhabditis elegans	nematode larval development [GO:0002119]; positive regulation of gastrulation [GO:2000543]; positive regulation of oocyte development [GO:0060282]; positive regulation of vulval development [GO:0040026]; transcription elongation-coupled chromatin remodeling [GO:0140673]	peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]	chromosome [GO:0005694]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000791; GO:0000993; GO:0002119; GO:0003723; GO:0003755; GO:0005634; GO:0005654; GO:0005694; GO:0040026; GO:0060282; GO:0140673; GO:2000543
GN015510	GN015510.1	Q9XTL9	60.9	412	389	844	1.59e-173	508	PYG_DROME	Glycogen phosphorylase (EC 2.4.1.1)	Drosophila melanogaster (Fruit fly)	defense response to Gram-negative bacterium [GO:0050829]; determination of adult lifespan [GO:0008340]; glycogen catabolic process [GO:0005980]; insulin receptor signaling pathway [GO:0008286]; negative regulation of innate immune response [GO:0045824]	glycogen phosphorylase activity [GO:0008184]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]	cytosol [GO:0005829]	GO:0005829; GO:0005980; GO:0008184; GO:0008286; GO:0008340; GO:0030170; GO:0042803; GO:0045824; GO:0050829
GN015511	GN015511.1	P79334	67.0	400	406	842	4.70e-194	561	PYGM_BOVIN	Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase)	Bos taurus (Bovine)	glycogen catabolic process [GO:0005980]	glycogen phosphorylase activity [GO:0008184]; pyridoxal phosphate binding [GO:0030170]	cytosol [GO:0005829]	GO:0005829; GO:0005980; GO:0008184; GO:0030170
GN015512	GN015512.1	P50416	58.7	436	589	773	1.60e-173	514	CPT1A_HUMAN	Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-)	Homo sapiens (Human)	carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; cellular response to fatty acid [GO:0071398]; eating behavior [GO:0042755]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; glucose metabolic process [GO:0006006]; liver regeneration [GO:0097421]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of innate immune response [GO:0045089]; regulation of insulin secretion [GO:0050796]; response to alkaloid [GO:0043279]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]; response to tetrachloromethane [GO:1904772]; response to xenobiotic stimulus [GO:0009410]; triglyceride metabolic process [GO:0006641]	carnitine O-palmitoyltransferase activity [GO:0004095]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]	membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0001666; GO:0001676; GO:0004095; GO:0005739; GO:0005741; GO:0006006; GO:0006631; GO:0006635; GO:0006641; GO:0006853; GO:0007584; GO:0009410; GO:0009437; GO:0016020; GO:0030674; GO:0030855; GO:0032000; GO:0042755; GO:0042802; GO:0043279; GO:0045089; GO:0045471; GO:0050796; GO:0071398; GO:0097421; GO:1904772
GN015513	GN015513.1	Q5ZIA5	77.1	362	366	953	7.62e-187	545	COPB_CHICK	Coatomer subunit beta (Beta-coat protein) (Beta-COP)	Gallus gallus (Chicken)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]	structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005198; GO:0005829; GO:0006886; GO:0006888; GO:0006891; GO:0030126
GN015515	GN015515.1	Q5EB30	50.8	65	92	256	1.09e-10	58.9	CMA1A_XENTR	Ciliary microtubule associated protein 1A (Outer dense fiber of sperm tails protein 3) (Outer dense fiber protein 3)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			cytoplasm [GO:0005737]	GO:0005737
GN015516	GN015516.1	Q96PU9	38.2	220	303	254	2.55e-38	139	CMA1A_HUMAN	Ciliary microtubule associated protein 1A (Outer dense fiber of sperm tails protein 3) (Outer dense fiber protein 3) (Sperm tail protein SHIPPO 1) (Transcript induced in spermiogenesis protein 50)	Homo sapiens (Human)	flagellated sperm motility [GO:0030317]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; outer dense fiber [GO:0001520]	GO:0001520; GO:0005737; GO:0005856; GO:0030317
GN015517	GN015517.1	Q9LJN4	34.8	652	743	781	6.99e-107	347	BXL5_ARATH	Probable beta-D-xylosidase 5 (AtBXL5) (EC 3.2.1.-)	Arabidopsis thaliana (Mouse-ear cress)	xylan catabolic process [GO:0045493]	xylan 1,4-beta-xylosidase activity [GO:0009044]	extracellular region [GO:0005576]; plant-type cell wall [GO:0009505]	GO:0005576; GO:0009044; GO:0009505; GO:0045493
GN015518	GN015518.1	P25169	23.9	222	333	315	4.99e-16	80.9	AT1B1_ARTSF	Sodium/potassium-transporting ATPase subunit beta (Sodium/potassium-dependent ATPase beta subunit)	Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)	intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; potassium ion import across plasma membrane [GO:1990573]; sodium ion export across plasma membrane [GO:0036376]	ATPase activator activity [GO:0001671]	sodium:potassium-exchanging ATPase complex [GO:0005890]	GO:0001671; GO:0005890; GO:0006883; GO:0030007; GO:0036376; GO:1990573
GN015519	GN015519.1	Q4PMB3	79.8	258	262	262	4.01e-150	422	RS4_IXOSC	Small ribosomal subunit protein eS4 (40S ribosomal protein S4)	Ixodes scapularis (Black-legged tick) (Deer tick)	translation [GO:0006412]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosolic small ribosomal subunit [GO:0022627]	GO:0003723; GO:0003735; GO:0006412; GO:0022627
GN015528	GN015528.1	Q8R116	39.0	546	565	503	4.38e-140	418	NOTUM_MOUSE	Palmitoleoyl-protein carboxylesterase NOTUM (EC 3.1.1.98)	Mus musculus (Mouse)	bone development [GO:0060348]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Wnt signaling pathway [GO:0030178]; protein depalmitoleylation [GO:1990697]; regulation of bone mineralization [GO:0030500]	lipase activity [GO:0016298]; palmitoleyl hydrolase activity [GO:1990699]; protein-containing complex destabilizing activity [GO:0140776]	extracellular region [GO:0005576]	GO:0005576; GO:0016298; GO:0030178; GO:0030500; GO:0060348; GO:0090090; GO:0140776; GO:1990697; GO:1990699
GN015537	GN015537.1	Q8NHU2	49.3	651	667	1237	2.58e-179	546	CFA61_HUMAN	Cilia- and flagella-associated protein 61	Homo sapiens (Human)	cilium movement [GO:0003341]; cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; sperm flagellum assembly [GO:0120316]; sperm mitochondrial sheath assembly [GO:0120317]		axoneme [GO:0005930]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]	GO:0003341; GO:0005930; GO:0030317; GO:0031514; GO:0036126; GO:0044782; GO:0120316; GO:0120317
GN015538	GN015538.1	Q8NHU2	48.7	119	130	1237	4.47e-33	125	CFA61_HUMAN	Cilia- and flagella-associated protein 61	Homo sapiens (Human)	cilium movement [GO:0003341]; cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; sperm flagellum assembly [GO:0120316]; sperm mitochondrial sheath assembly [GO:0120317]		axoneme [GO:0005930]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]	GO:0003341; GO:0005930; GO:0030317; GO:0031514; GO:0036126; GO:0044782; GO:0120316; GO:0120317
GN015539	GN015539.1	Q8CEL2	37.8	111	111	1252	5.21e-23	95.5	CFA61_MOUSE	Cilia- and flagella-associated protein 61	Mus musculus (Mouse)	cilium movement [GO:0003341]; cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; sperm flagellum assembly [GO:0120316]; spermatid nucleus elongation [GO:0007290]		axoneme [GO:0005930]; manchette [GO:0002177]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; radial spoke stalk [GO:0001536]; sperm flagellum [GO:0036126]	GO:0001534; GO:0001536; GO:0002177; GO:0003341; GO:0005930; GO:0007290; GO:0030317; GO:0031514; GO:0036126; GO:0044782; GO:0120316
GN015541	GN015541.1	A0A1D5NSM8	22.4	437	557	3615	7.69e-12	72.4	SVEP1_DANRE	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)	Danio rerio (Zebrafish) (Brachydanio rerio)	cell migration [GO:0016477]; epidermal cell differentiation [GO:0009913]; epidermis development [GO:0008544]; epithelial cell-cell adhesion [GO:0090136]; lymph vessel development [GO:0001945]; lymph vessel morphogenesis [GO:0036303]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0001945; GO:0005509; GO:0005576; GO:0005634; GO:0005737; GO:0008544; GO:0009913; GO:0016020; GO:0016477; GO:0036303; GO:0090136
GN015543	GN015543.1	P71359	27.6	134	120	619	7.01e-11	61.2	RECQ_HAEIN	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]	GO:0003676; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0009432; GO:0016887; GO:0030894; GO:0043138; GO:0043590
GN015548	GN015548.1	Q8TER0	37.2	282	582	1413	5.49e-49	187	SNED1_HUMAN	Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)	Homo sapiens (Human)	cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]	calcium ion binding [GO:0005509]; Notch binding [GO:0005112]	extracellular matrix [GO:0031012]	GO:0005112; GO:0005509; GO:0007160; GO:0031012; GO:0033627
GN015549	GN015549.1	A6QP74	29.9	355	497	462	3.19e-38	148	CALRL_BOVIN	Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; receptor internalization [GO:0031623]	adrenomedullin receptor activity [GO:0001605]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948]	plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001525; GO:0001605; GO:0001635; GO:0004948; GO:0005886; GO:0007166; GO:0007189; GO:0031623; GO:0043235
GN015551	GN015551.1	Q6NT16	35.0	274	337	456	3.17e-47	168	S18B1_HUMAN	MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) (Vesicular polyamine transporter) (VPAT)	Homo sapiens (Human)	serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; spermine transport [GO:0000296]	monoamine:proton antiporter activity [GO:0015311]; polyamine:proton antiporter activity [GO:0015312]; transmembrane transporter activity [GO:0022857]	secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]	GO:0000296; GO:0015311; GO:0015312; GO:0015848; GO:0022857; GO:0030667; GO:0030672; GO:0051610
GN015553	GN015553.1	G5EBI4	43.4	198	202	404	8.73e-44	153	CEEH1_CAEEL	Epoxide hydrolase 1 (EC 3.3.2.10) (CEEH1)	Caenorhabditis elegans	lipid metabolic process [GO:0006629]	epoxide hydrolase activity [GO:0004301]	membrane [GO:0016020]	GO:0004301; GO:0006629; GO:0016020
GN015555	GN015555.1	Q9JLC8	24.8	4579	4166	4582	4.86e-297	1007	SACS_MOUSE	Sacsin (DnaJ homolog subfamily C member 29)	Mus musculus (Mouse)	negative regulation of inclusion body assembly [GO:0090084]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0090084
GN015556	GN015556.1	Q9JLC8	25.3	4585	4204	4582	2.60e-316	1066	SACS_MOUSE	Sacsin (DnaJ homolog subfamily C member 29)	Mus musculus (Mouse)	negative regulation of inclusion body assembly [GO:0090084]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0090084
GN015557	GN015557.1	Q8VHR5	47.7	262	699	594	2.82e-46	177	P66B_MOUSE	Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)	Mus musculus (Mouse)	chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]	GO:0000122; GO:0000781; GO:0000981; GO:0005634; GO:0005654; GO:0005694; GO:0006338; GO:0008270; GO:0016581; GO:0016607; GO:0042659; GO:0043565; GO:0045892; GO:0045893; GO:2000736
GN015559	GN015559.1	Q5ZLS2	39.5	549	533	506	3.24e-111	343	EDC3_CHICK	Enhancer of mRNA-decapping protein 3 (YjeF domain-containing protein 1)	Gallus gallus (Chicken)	deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; P-body assembly [GO:0033962]	mRNA binding [GO:0003729]	P-body [GO:0000932]	GO:0000932; GO:0003729; GO:0031087; GO:0033962
GN015561	GN015561.1	Q9GL21	52.4	84	959	1415	2.26e-11	72.0	UACA_CANLF	Uveal autoantigen with coiled-coil domains and ankyrin repeats	Canis lupus familiaris (Dog) (Canis familiaris)	intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of inflammatory response [GO:0050728]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]	actin binding [GO:0003779]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003779; GO:0005634; GO:0005829; GO:0005856; GO:0008630; GO:0008631; GO:0050728; GO:1901223
GN015562	GN015562.1	P23377	52.6	568	945	793	1.33e-187	563	FURIN_RAT	Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) (Prohormone convertase 3)	Rattus norvegicus (Rat)	blastocyst formation [GO:0001825]; cholesterol homeostasis [GO:0042632]; cytokine precursor processing [GO:0140447]; dibasic protein processing [GO:0090472]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor production [GO:0032902]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; positive regulation of cell migration [GO:0030335]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein maturation [GO:0051604]; protein processing [GO:0016485]; regulation of cholesterol transport [GO:0032374]; regulation of protein catabolic process [GO:0042176]; regulation of signal transduction [GO:0009966]; secretion by cell [GO:0032940]; viral life cycle [GO:0019058]; zymogen activation [GO:0031638]; zymogen inhibition [GO:0097341]	endopeptidase activator activity [GO:0061133]; endopeptidase activity [GO:0004175]; endopeptidase inhibitor activity [GO:0004866]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; nerve growth factor binding [GO:0048406]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; serine-type endopeptidase inhibitor activity [GO:0004867]; serine-type peptidase activity [GO:0008236]; signal peptidase activity [GO:0009003]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]	GO:0000139; GO:0001825; GO:0002020; GO:0004175; GO:0004252; GO:0004866; GO:0004867; GO:0005576; GO:0005783; GO:0005789; GO:0005794; GO:0005796; GO:0005802; GO:0005886; GO:0008201; GO:0008233; GO:0008236; GO:0009003; GO:0009966; GO:0009986; GO:0010008; GO:0016485; GO:0016486; GO:0019058; GO:0030140; GO:0030335; GO:0030511; GO:0031638; GO:0031985; GO:0032374; GO:0032804; GO:0032902; GO:0032911; GO:0032940; GO:0042176; GO:0042277; GO:0042632; GO:0043043; GO:0045121; GO:0048406; GO:0051604; GO:0061133; GO:0090472; GO:0097341; GO:0140447; GO:1904399
GN015563	GN015563.1	O96011	30.9	220	227	259	2.70e-29	113	PX11B_HUMAN	Peroxisomal membrane protein 11B (Peroxin-11B) (Peroxisomal biogenesis factor 11B) (Protein PEX11 homolog beta) (PEX11-beta)	Homo sapiens (Human)	peroxisome fission [GO:0016559]; peroxisome organization [GO:0007031]; regulation of peroxisome size [GO:0044375]; signal transduction [GO:0007165]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	GO:0005739; GO:0005777; GO:0005778; GO:0005829; GO:0007031; GO:0007165; GO:0016020; GO:0016559; GO:0032991; GO:0042802; GO:0042803; GO:0044375
GN015564	GN015564.1	Q0VCP2	33.2	241	247	247	1.47e-32	122	PX11A_BOVIN	Peroxisomal membrane protein 11A (Peroxin-11A) (Peroxisomal biogenesis factor 11A)	Bos taurus (Bovine)	peroxisome fission [GO:0016559]		peroxisomal membrane [GO:0005778]	GO:0005778; GO:0016559
GN015565	GN015565.1	Q6P2C0	27.1	660	782	686	5.31e-58	213	WDR93_HUMAN	WD repeat-containing protein 93	Homo sapiens (Human)	electron transport chain [GO:0022900]			GO:0022900
GN015566	GN015566.1	Q5ZLD3	29.4	326	618	629	1.55e-41	162	KLH13_CHICK	Kelch-like protein 13	Gallus gallus (Chicken)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]	GO:0005829; GO:0016567; GO:0031463; GO:0032465; GO:0043161; GO:1990756
GN015570	GN015570.1	Q8N357	39.3	196	247	371	3.12e-35	132	S35F6_HUMAN	Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog)	Homo sapiens (Human)	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation of cell population proliferation [GO:0008284]	transmembrane transporter activity [GO:0022857]	extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrion [GO:0005739]	GO:0005739; GO:0005765; GO:0008284; GO:0016020; GO:0022857; GO:0070062; GO:1901029
GN015571	GN015571.1	Q21263	61.8	123	566	351	2.37e-43	161	PAX2H_CAEEL	Paired box protein 2 homolog (Paired box transcription factor 2)	Caenorhabditis elegans	apoptotic process [GO:0006915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0005634; GO:0005694; GO:0006357; GO:0006915; GO:0045944
GN015572	GN015572.1	A0JPI9	44.4	81	158	479	1.61e-17	81.6	LR74A_RAT	Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74)	Rattus norvegicus (Rat)				
GN015580	GN015580.1	Q9M2U3	29.6	152	153	406	9.01e-13	67.8	ALPL_ARATH	Protein ALP1-like (EC 3.1.-.-)	Arabidopsis thaliana (Mouse-ear cress)			histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634
GN015582	GN015582.1	Q071E0	34.4	128	726	344	8.40e-09	61.6	KT5AA_DANRE	N-lysine methyltransferase KMT5A-A (EC 2.1.1.-) (Histone-lysine N-methyltransferase KMT5A-A) (EC 2.1.1.361) (Lysine-specific methylase 5A-A) (SET domain-containing protein 8-A)	Danio rerio (Zebrafish) (Brachydanio rerio)	dorsal/ventral pattern formation [GO:0009953]; positive regulation of gene expression [GO:0010628]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279]	chromosome [GO:0005694]; nucleus [GO:0005634]; polytene chromosome [GO:0005700]	GO:0005634; GO:0005694; GO:0005700; GO:0006357; GO:0009953; GO:0010628; GO:0016279; GO:0042054; GO:0042799; GO:0043516; GO:0140944
GN015586	GN015586.1	Q68EY7	54.5	213	211	217	3.32e-56	180	C124A_XENLA	Coiled-coil domain-containing protein 124-A	Xenopus laevis (African clawed frog)	transcription by RNA polymerase II [GO:0006366]	transcription coactivator activity [GO:0003713]	centrosome [GO:0005813]; midbody [GO:0030496]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005813; GO:0006366; GO:0030496
GN015592	GN015592.1	Q9VZW5	28.1	324	484	549	8.94e-33	134	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN015593	GN015593.1	Q17QR8	29.5	146	219	349	1.42e-14	74.7	HARB1_BOVIN	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Bos taurus (Bovine)			cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005829; GO:0005886
GN015596	GN015596.1	A2AKG8	27.5	531	514	1798	1.74e-56	207	FOCAD_MOUSE	Focadhesin	Mus musculus (Mouse)	regulation of post-transcriptional gene silencing [GO:0060147]		cytosol [GO:0005829]; focal adhesion [GO:0005925]	GO:0005829; GO:0005925; GO:0060147
GN015599	GN015599.1	Q5BK75	25.1	431	486	461	1.52e-22	103	S46A3_RAT	Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)	Rattus norvegicus (Rat)	cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; vacuolar transmembrane transport [GO:0034486]	copper ion transmembrane transporter activity [GO:0005375]; transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]	GO:0005375; GO:0005765; GO:0022857; GO:0034486; GO:1904613
GN015600	GN015600.1	Q9DC26	25.2	369	454	460	5.84e-20	95.5	S46A3_MOUSE	Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)	Mus musculus (Mouse)	cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; vacuolar transmembrane transport [GO:0034486]	copper ion transmembrane transporter activity [GO:0005375]; transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]	GO:0005375; GO:0005765; GO:0022857; GO:0034486; GO:1904613
GN015603	GN015603.1	P86880	33.3	156	159	159	8.30e-21	86.3	NGB_CHAAC	Neuroglobin (Nitrite reductase) (EC 1.7.-.-)	Chaenocephalus aceratus (Blackfin icefish) (Chaenichthys aceratus)	cellular response to hypoxia [GO:0071456]	GDP-dissociation inhibitor activity [GO:0005092]; heme binding [GO:0020037]; nitrite reductase activity [GO:0098809]; oxygen binding [GO:0019825]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]	GO:0005092; GO:0005759; GO:0005829; GO:0019825; GO:0020037; GO:0071456; GO:0098809
GN015607	GN015607.1	Q7M456	46.3	229	258	213	1.41e-71	221	RNOY_MAGGI	Ribonuclease Oy (RNase Oy) (EC 3.1.27.-)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	RNA catabolic process [GO:0006401]	ribonuclease T2 activity [GO:0033897]; RNA binding [GO:0003723]	extracellular region [GO:0005576]	GO:0003723; GO:0005576; GO:0006401; GO:0033897
GN015608	GN015608.1	P50991	76.5	514	536	539	2.31e-278	769	TCPD_HUMAN	T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding)	Homo sapiens (Human)	positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]	cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; microtubule [GO:0005874]; zona pellucida receptor complex [GO:0002199]	GO:0002199; GO:0003723; GO:0005524; GO:0005737; GO:0005813; GO:0005829; GO:0005832; GO:0005874; GO:0006457; GO:0016887; GO:0032212; GO:0042470; GO:0044183; GO:0044297; GO:0050821; GO:0070062; GO:0090666; GO:0140662; GO:1904871; GO:1904874
GN015609	GN015609.1	Q9JI99	35.8	187	195	430	1.63e-26	107	SGPP1_MOUSE	Sphingosine-1-phosphate phosphatase 1 (SPP) (SPPase1) (mSPP1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1)	Mus musculus (Mouse)	ER to Golgi ceramide transport [GO:0035621]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway [GO:0097193]; phospholipid dephosphorylation [GO:0046839]; regulation of epidermis development [GO:0045682]; regulation of keratinocyte differentiation [GO:0045616]; sphinganine-1-phosphate metabolic process [GO:0006668]; sphingolipid metabolic process [GO:0006665]; sphingosine metabolic process [GO:0006670]	dihydrosphingosine-1-phosphate phosphatase activity [GO:0070780]; sphingosine-1-phosphate phosphatase activity [GO:0042392]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0005654; GO:0005783; GO:0005789; GO:0005886; GO:0006665; GO:0006668; GO:0006670; GO:0016020; GO:0035621; GO:0042392; GO:0045616; GO:0045682; GO:0046839; GO:0070780; GO:0097191; GO:0097193
GN015613	GN015613.1	Q0E908	20.8	501	827	818	2.11e-23	110	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN015615	GN015615.1	P08953	23.5	463	681	1097	2.96e-20	99.8	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN015616	GN015616.1	P08953	23.8	463	681	1097	3.50e-22	105	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN015618	GN015618.1	P08953	24.2	472	681	1097	2.86e-23	109	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN015619	GN015619.1	P11240	39.5	152	182	146	4.38e-24	95.1	COX5A_RAT	Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)	Rattus norvegicus (Rat)	mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]	cytochrome-c oxidase activity [GO:0004129]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; respiratory chain complex IV [GO:0045277]	GO:0004129; GO:0005739; GO:0005743; GO:0006123; GO:0031966; GO:0045277
GN015622	GN015622.1	P49914	40.2	194	226	203	7.62e-42	144	MTHFS_HUMAN	5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)	Homo sapiens (Human)	folic acid catabolic process [GO:0046657]; folic acid metabolic process [GO:0046655]; folic acid-containing compound biosynthetic process [GO:0009396]; formate metabolic process [GO:0015942]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	5-formyltetrahydrofolate cyclo-ligase activity [GO:0030272]; ATP binding [GO:0005524]; folic acid binding [GO:0005542]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005524; GO:0005542; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0009396; GO:0015942; GO:0030272; GO:0035999; GO:0046653; GO:0046655; GO:0046657
GN015623	GN015623.1	A0A345BJN8	31.0	248	606	919	1.74e-24	112	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN015624	GN015624.1	Q9NPJ1	30.6	553	574	570	5.78e-71	241	MKKS_HUMAN	Molecular chaperone MKKS (Bardet-Biedl syndrome 6 protein) (McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin)	Homo sapiens (Human)	brain morphogenesis [GO:0048854]; cerebral cortex development [GO:0021987]; chaperone-mediated protein complex assembly [GO:0051131]; cilium assembly [GO:0060271]; convergent extension involved in gastrulation [GO:0060027]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; determination of left/right symmetry [GO:0007368]; developmental process [GO:0032502]; fat cell differentiation [GO:0045444]; gonad development [GO:0008406]; heart development [GO:0007507]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; melanosome transport [GO:0032402]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; photoreceptor cell maintenance [GO:0045494]; pigment granule aggregation in cell center [GO:0051877]; protein folding [GO:0006457]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; sensory perception of smell [GO:0007608]; social behavior [GO:0035176]; spermatid development [GO:0007286]; striatum development [GO:0021756]	ATP binding [GO:0005524]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinociliary basal body [GO:1902636]; motile cilium [GO:0031514]; nucleus [GO:0005634]	GO:0001947; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0006457; GO:0007286; GO:0007368; GO:0007507; GO:0007608; GO:0008406; GO:0021756; GO:0021766; GO:0021987; GO:0031514; GO:0032402; GO:0032502; GO:0035176; GO:0036064; GO:0038108; GO:0045444; GO:0045494; GO:0048854; GO:0050910; GO:0051131; GO:0051877; GO:0060027; GO:0060271; GO:0060296; GO:0061629; GO:1902636
GN015630	GN015630.1	Q40302	60.0	140	141	149	5.52e-56	174	CALM_MACPY	Calmodulin (CaM)	Macrocystis pyrifera (Giant kelp) (Fucus pyrifer)		calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; myosin II complex [GO:0016460]	GO:0005509; GO:0005737; GO:0016460
GN015631	GN015631.1	Q6ZU80	29.9	371	1031	1094	6.24e-19	96.7	CE128_HUMAN	Centrosomal protein 128 (Cep128) (Centrosomal protein of 128 kDa)	Homo sapiens (Human)	intracellular protein localization [GO:0008104]; motile cilium assembly [GO:0044458]; negative regulation of cilium assembly [GO:1902018]; positive regulation of protein localization [GO:1903829]; regulation of gene expression [GO:0010468]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; sperm flagellum assembly [GO:0120316]		centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; sperm head-tail coupling apparatus [GO:0120212]; spindle pole [GO:0000922]	GO:0000922; GO:0005813; GO:0005814; GO:0008104; GO:0010468; GO:0017015; GO:0036064; GO:0044458; GO:0120103; GO:0120212; GO:0120316; GO:1902018; GO:1903829
GN015632	GN015632.1	Q8N5M4	35.7	171	230	171	7.99e-28	107	TTC9C_HUMAN	Tetratricopeptide repeat protein 9C (TPR repeat protein 9C)	Homo sapiens (Human)				
GN015633	GN015633.1	Q9DBZ5	64.0	214	220	218	7.32e-97	284	EIF3K_MOUSE	Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (eIF-3 p25)	Mus musculus (Mouse)	formation of cytoplasmic translation initiation complex [GO:0001732]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; nucleus [GO:0005634]	GO:0001732; GO:0003723; GO:0003743; GO:0005634; GO:0005829; GO:0005852; GO:0006413; GO:0006446; GO:0016282; GO:0033290; GO:0043022
GN015635	GN015635.1	Q8NI22	51.0	100	167	146	1.75e-25	98.2	MCFD2_HUMAN	Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein)	Homo sapiens (Human)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]	calcium ion binding [GO:0005509]	cargo receptor complex [GO:0062137]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]	GO:0005509; GO:0005789; GO:0005794; GO:0006888; GO:0012507; GO:0033116; GO:0062137
GN015636	GN015636.1	L8E946	58.3	120	125	279	2.33e-24	97.1	UNC42_CAEEL	Homeobox protein unc-42 (Uncoordinated protein 42)	Caenorhabditis elegans	axon development [GO:0061564]; axon guidance [GO:0007411]; larval locomotory behavior [GO:0008345]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate specification [GO:0048665]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; synapse organization [GO:0050808]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0007411; GO:0008345; GO:0010468; GO:0030182; GO:0045944; GO:0048665; GO:0048666; GO:0050808; GO:0061564
GN015638	GN015638.1	P0CB95	67.2	131	171	175	3.85e-60	187	NDUS4_PONAB	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (NADH-ubiquinone oxidoreductase 18 kDa subunit)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	brain development [GO:0007420]; electron transport chain [GO:0022900]; mitochondrial respiratory chain complex I assembly [GO:0032981]; reactive oxygen species metabolic process [GO:0072593]; response to cAMP [GO:0051591]	NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; respiratory chain complex I [GO:0045271]	GO:0005743; GO:0007420; GO:0008137; GO:0022900; GO:0032981; GO:0045271; GO:0051591; GO:0072593
GN015639	GN015639.1	O08762	58.3	103	667	761	4.51e-31	133	NETR_MOUSE	Neurotrypsin (EC 3.4.21.-) (Brain-specific serine protease 3) (BSSP-3) (Motopsin) (Serine protease 12)	Mus musculus (Mouse)	exocytosis [GO:0006887]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; synaptic cleft [GO:0043083]; terminal bouton [GO:0043195]	GO:0004252; GO:0005886; GO:0006508; GO:0006887; GO:0008233; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195; GO:0045202; GO:0098685; GO:0098793; GO:0098978
GN015645	GN015645.1	Q66JT5	44.4	270	328	296	2.00e-72	229	TPGS2_MOUSE	Tubulin polyglutamylase complex subunit 2 (PGs2)	Mus musculus (Mouse)	cilium disassembly [GO:0061523]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]	protein-macromolecule adaptor activity [GO:0030674]	centriolar satellite [GO:0034451]; cytosol [GO:0005829]; microtubule [GO:0005874]	GO:0000226; GO:0005829; GO:0005874; GO:0030674; GO:0034451; GO:0046785; GO:0061523
GN015648	GN015648.1	Q922Y2	29.5	146	428	403	3.48e-13	74.3	TRI59_MOUSE	Tripartite motif-containing protein 59 (EC 2.3.2.27) (RING finger protein 1)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; host-mediated suppression of symbiont invasion [GO:0046597]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0008270; GO:0016567; GO:0043124; GO:0045087; GO:0046597; GO:0061630; GO:0140374
GN015655	GN015655.1	Q6GQQ9	43.7	483	1066	843	1.15e-100	340	OTU7B_HUMAN	OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)	Homo sapiens (Human)	mucosal immune response [GO:0002385]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of TORC2 signaling [GO:1904515]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; DNA binding [GO:0003677]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000122; GO:0002385; GO:0003677; GO:0004843; GO:0005634; GO:0005737; GO:0005829; GO:0008234; GO:0008270; GO:0016579; GO:0032717; GO:0035871; GO:0043124; GO:0070530; GO:0070536; GO:0071108; GO:0071947; GO:1900181; GO:1904262; GO:1904515; GO:1990380
GN015656	GN015656.1	Q8BNU0	42.1	297	318	468	5.70e-72	233	ARMC6_MOUSE	Armadillo repeat-containing protein 6	Mus musculus (Mouse)	hematopoietic progenitor cell differentiation [GO:0002244]		cytosol [GO:0005829]	GO:0002244; GO:0005829
GN015657	GN015657.1	Q8K0U4	31.1	630	590	675	2.05e-89	293	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN015660	GN015660.1	Q501Z5	50.2	524	558	500	1.20e-161	473	GTPB3_DANRE	5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial (EC 3.6.1.-) (GTP-binding protein 3) (tRNA modification GTPase GTPBP3, mitochondrial)	Danio rerio (Zebrafish) (Brachydanio rerio)	embryonic organ development [GO:0048568]; mitochondrial alanyl-tRNA aminoacylation [GO:0070143]; mitochondrial leucyl-tRNA aminoacylation [GO:0070153]; mitochondrial lysyl-tRNA aminoacylation [GO:0070154]; mitochondrial methionyl-tRNA aminoacylation [GO:0070155]; mitochondrial tRNA modification [GO:0070900]; mitochondrial tRNA wobble uridine modification [GO:0070899]; mitochondrial tryptophanyl-tRNA aminoacylation [GO:0070183]; mitochondrial tyrosyl-tRNA aminoacylation [GO:0070184]; tRNA methylation [GO:0030488]; tRNA stabilization [GO:0036416]; tRNA wobble uridine modification [GO:0002098]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0002098; GO:0003924; GO:0005525; GO:0005737; GO:0005739; GO:0030488; GO:0036416; GO:0048568; GO:0070143; GO:0070153; GO:0070154; GO:0070155; GO:0070183; GO:0070184; GO:0070899; GO:0070900
GN015664	GN015664.1	Q642J4	37.6	101	398	317	1.85e-11	68.2	IMPCT_DANRE	Protein IMPACT (Imprinted and ancient gene protein homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to amino acid starvation [GO:0034198]; GCN2-mediated signaling [GO:0140469]; intracellular signal transduction [GO:0035556]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron projection extension [GO:1990138]; positive regulation of neuron differentiation [GO:0045666]; regulation of cytoplasmic translational initiation in response to stress [GO:1990611]; regulation of translational initiation [GO:0006446]	protein sequestering activity [GO:0140311]	cytoplasm [GO:0005737]	GO:0000122; GO:0005737; GO:0006446; GO:0034198; GO:0035556; GO:0045666; GO:0140311; GO:0140469; GO:1990138; GO:1990611
GN015665	GN015665.1	P70684	39.1	243	254	265	3.86e-50	168	PGDH_CAVPO	15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Eicosanoid/docosanoid dehydrogenase [NAD(+)]) (EC 1.1.1.-, EC 1.1.1.232) (Prostaglandin dehydrogenase 1)	Cavia porcellus (Guinea pig)	ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; regulation of prostaglandin catabolic process [GO:1905828]; thrombin-activated receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179]	15-hydroxyicosatetraenoate dehydrogenase activity [GO:0047034]; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity [GO:0016404]; NAD binding [GO:0051287]; NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E receptor activity [GO:0004957]	cytoplasm [GO:0005737]	GO:0004957; GO:0005737; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016404; GO:0016616; GO:0030728; GO:0045786; GO:0047034; GO:0051287; GO:0070403; GO:0070493; GO:0097070; GO:1905828
GN015666	GN015666.1	Q9D6N1	42.7	75	142	262	6.21e-14	69.7	CAH13_MOUSE	Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonate dehydratase XIII) (Carbonic anhydrase XIII) (CA-XIII)	Mus musculus (Mouse)		carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; myelin sheath [GO:0043209]	GO:0004089; GO:0005737; GO:0005829; GO:0008270; GO:0043209
GN015667	GN015667.1	Q8UWA5	49.8	259	289	260	7.48e-83	253	CAH2_PSEHK	Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II)	Pseudaspius hakonensis (Big-scaled redfin) (Tribolodon hakonensis)	carbon dioxide transport [GO:0015670]; regulation of pH [GO:0006885]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004089; GO:0005737; GO:0005886; GO:0006885; GO:0008270; GO:0015670
GN015673	GN015673.1	Q6IR75	86.8	439	441	441	6.67e-271	743	CSN2_XENLA	COP9 signalosome complex subunit 2 (Signalosome subunit 2)	Xenopus laevis (African clawed frog)			COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]	GO:0005737; GO:0008180
GN015675	GN015675.1	O35245	26.3	460	583	966	7.68e-44	171	PKD2_MOUSE	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Transient receptor potential cation channel subfamily P member 2)	Mus musculus (Mouse)	aorta development [GO:0035904]; branching involved in ureteric bud morphogenesis [GO:0001658]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway via JAK-STAT [GO:0007259]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to osmotic stress [GO:0071470]; cilium organization [GO:0044782]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; embryonic placenta development [GO:0001892]; heart development [GO:0007507]; heart looping [GO:0001947]; intracellular calcium ion homeostasis [GO:0006874]; kidney development [GO:0001822]; liver development [GO:0001889]; mesonephric duct development [GO:0072177]; metanephric ascending thin limb development [GO:0072218]; metanephric cortex development [GO:0072214]; metanephric cortical collecting duct development [GO:0072219]; metanephric distal tubule development [GO:0072235]; metanephric mesenchyme development [GO:0072075]; metanephric part of ureteric bud development [GO:0035502]; metanephric S-shaped body morphogenesis [GO:0072284]; metanephric smooth muscle tissue development [GO:0072208]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neural tube development [GO:0021915]; placenta blood vessel development [GO:0060674]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of transcription by RNA polymerase II [GO:0045944]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein heterotetramerization [GO:0051290]; protein homotetramerization [GO:0051289]; protein tetramerization [GO:0051262]; regulation of calcium ion import [GO:0090279]; regulation of cell cycle [GO:0051726]; regulation of cell population proliferation [GO:0042127]; release of sequestered calcium ion into cytosol [GO:0051209]; renal artery morphogenesis [GO:0061441]; renal tubule morphogenesis [GO:0061333]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; spinal cord development [GO:0021510]; transmembrane transport [GO:0055085]; Wnt signaling pathway [GO:0016055]	actinin binding [GO:0042805]; alpha-actinin binding [GO:0051393]; ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; channel activity [GO:0015267]; cytoskeletal protein binding [GO:0008092]; HLH domain binding [GO:0043398]; identical protein binding [GO:0042802]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; outward rectifier potassium channel activity [GO:0015271]; phosphoprotein binding [GO:0051219]; potassium channel activity [GO:0005267]; protein homodimerization activity [GO:0042803]; signaling receptor binding [GO:0005102]; sodium channel activity [GO:0005272]; transcription regulator inhibitor activity [GO:0140416]; transmembrane transporter binding [GO:0044325]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated monoatomic cation channel activity [GO:0022843]; voltage-gated monoatomic ion channel activity [GO:0005244]; voltage-gated potassium channel activity [GO:0005249]; voltage-gated sodium channel activity [GO:0005248]	basal cortex [GO:0045180]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cation channel complex [GO:0034703]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]; migrasome [GO:0140494]; mitotic spindle [GO:0072686]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]; polycystin complex [GO:0002133]; vesicle [GO:0031982]	GO:0001658; GO:0001822; GO:0001889; GO:0001892; GO:0001947; GO:0002133; GO:0003127; GO:0005102; GO:0005244; GO:0005245; GO:0005248; GO:0005249; GO:0005261; GO:0005262; GO:0005267; GO:0005272; GO:0005509; GO:0005737; GO:0005783; GO:0005789; GO:0005794; GO:0005829; GO:0005886; GO:0005929; GO:0006813; GO:0006814; GO:0006816; GO:0006874; GO:0007166; GO:0007204; GO:0007259; GO:0007368; GO:0007507; GO:0008092; GO:0009925; GO:0010628; GO:0015267; GO:0015271; GO:0016020; GO:0016055; GO:0016323; GO:0021510; GO:0021915; GO:0022843; GO:0030027; GO:0030659; GO:0031514; GO:0031982; GO:0034703; GO:0035502; GO:0035725; GO:0035904; GO:0036064; GO:0042127; GO:0042802; GO:0042803; GO:0042805; GO:0043398; GO:0044325; GO:0044782; GO:0045180; GO:0045429; GO:0045944; GO:0048763; GO:0050982; GO:0051117; GO:0051209; GO:0051219; GO:0051262; GO:0051289; GO:0051290; GO:0051371; GO:0051393; GO:0051726; GO:0055085; GO:0060170; GO:0060315; GO:0060674; GO:0061333; GO:0061441; GO:0070062; GO:0070588; GO:0071277; GO:0071320; GO:0071464; GO:0071470; GO:0071498; GO:0071805; GO:0071910; GO:0072075; GO:0072177; GO:0072208; GO:0072214; GO:0072218; GO:0072219; GO:0072235; GO:0072284; GO:0072686; GO:0090279; GO:0097730; GO:0098553; GO:0098554; GO:0140416; GO:0140494; GO:1900738; GO:2000134
GN015683	GN015683.1	Q9TTF0	53.8	342	380	411	1.24e-110	332	NR2E3_BOVIN	Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor)	Bos taurus (Bovine)	neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]	nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0000978; GO:0004879; GO:0005634; GO:0008270; GO:0030182; GO:0045944
GN015684	GN015684.1	Q9BQT8	62.4	295	306	299	1.93e-133	383	ODC_HUMAN	Mitochondrial 2-oxodicarboxylate carrier (ODC) (Mitochondrial 2-oxoadipate carrier) (Solute carrier family 25 member 21)	Homo sapiens (Human)	L-lysine catabolic process [GO:0019477]; mitochondrial alpha-ketoglutarate transmembrane transport [GO:1990550]	alpha-ketoglutarate transmembrane transporter activity [GO:0015139]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0015139; GO:0019477; GO:1990550
GN015685	GN015685.1	Q29RU1	57.9	126	128	139	7.84e-41	135	RT12_BOVIN	Small ribosomal subunit protein uS12m (28S ribosomal protein S12, mitochondrial) (MRP-S12) (S12mt)	Bos taurus (Bovine)	mitochondrial translation [GO:0032543]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; ribosome [GO:0005840]	GO:0003735; GO:0005739; GO:0005743; GO:0005763; GO:0005840; GO:0006412; GO:0032543
GN015686	GN015686.1	B2RY56	54.9	771	764	838	5.75e-131	412	RBM25_MOUSE	RNA-binding protein 25 (RNA-binding motif protein 25)	Mus musculus (Mouse)	regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]	GO:0000381; GO:0003729; GO:0005737; GO:0016607; GO:0042981
GN015703	GN015703.1	P48039	24.1	270	369	350	2.43e-12	70.9	MTR1A_HUMAN	Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)	Homo sapiens (Human)	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; mating behavior [GO:0007617]	G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; melatonin receptor activity [GO:0008502]	plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004930; GO:0005886; GO:0007187; GO:0007193; GO:0007617; GO:0007623; GO:0008502; GO:0042562; GO:0043235
GN015715	GN015715.1	Q810V0	41.1	686	823	681	2.88e-108	350	MPP10_MOUSE	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10)	Mus musculus (Mouse)	ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]		chromosome [GO:0005694]; Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]	GO:0005694; GO:0005730; GO:0005732; GO:0006364; GO:0032040; GO:0034457; GO:0042274
GN015716	GN015716.1	Q60803	38.2	570	560	567	1.76e-109	341	TRAF3_MOUSE	TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (RING-type E3 ubiquitin transferase TRAF3)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cell surface receptor signaling pathway [GO:0007166]; mRNA transcription [GO:0009299]; positive regulation of type I interferon production [GO:0032481]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; endosome [GO:0005768]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]	GO:0001817; GO:0002224; GO:0004842; GO:0005164; GO:0005737; GO:0005739; GO:0005768; GO:0007166; GO:0008063; GO:0008270; GO:0009299; GO:0009898; GO:0010008; GO:0019901; GO:0019903; GO:0030162; GO:0031625; GO:0031996; GO:0032481; GO:0032648; GO:0033209; GO:0034142; GO:0035591; GO:0035631; GO:0042802; GO:0042981; GO:0043122; GO:0050688; GO:0061630; GO:0140374
GN015717	GN015717.1	Q0IH86	50.5	273	289	282	3.82e-103	305	SLX1_XENLA	Structure-specific endonuclease subunit slx1 (EC 3.1.-.-) (GIY-YIG domain-containing protein 1)	Xenopus laevis (African clawed frog)	double-strand break repair via homologous recombination [GO:0000724]; regulation of telomere maintenance [GO:0032204]; t-circle formation [GO:0090656]	5'-flap endonuclease activity [GO:0017108]; crossover junction DNA endonuclease activity [GO:0008821]	Slx1-Slx4 complex [GO:0033557]	GO:0000724; GO:0008821; GO:0017108; GO:0032204; GO:0033557; GO:0090656
GN015718	GN015718.1	Q96B67	40.3	414	431	414	5.99e-98	302	ARRD3_HUMAN	Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)	Homo sapiens (Human)	negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of hippo signaling [GO:0035332]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]	beta-3 adrenergic receptor binding [GO:0031699]; molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0031699; GO:0035332; GO:0051443; GO:0060090; GO:0120163
GN015722	GN015722.1	Q92797	51.2	1102	1443	1274	0.0	1027	SYMPK_HUMAN	Symplekin	Homo sapiens (Human)	mRNA 3'-end processing [GO:0031124]; negative regulation of protein binding [GO:0032091]; nuclear histone mRNA catabolic process [GO:0071045]		bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; mRNA cleavage factor complex [GO:0005849]; nuclear stress granule [GO:0097165]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005654; GO:0005737; GO:0005847; GO:0005849; GO:0005856; GO:0005886; GO:0005923; GO:0031124; GO:0032091; GO:0071045; GO:0097165
GN015725	GN015725.1	Q9VAY7	57.6	368	335	359	2.83e-128	374	FAM50_DROME	Protein FAM50 homolog	Drosophila melanogaster (Fruit fly)	chromatin organization [GO:0006325]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]	GO:0003723; GO:0005654; GO:0006325
GN015727	GN015727.1	V5NAL9	35.2	684	713	899	9.07e-104	340	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN015729	GN015729.1	Q96MP8	30.4	224	218	289	1.67e-26	106	KCTD7_HUMAN	BTB/POZ domain-containing protein KCTD7	Homo sapiens (Human)	intracellular glutamate homeostasis [GO:0090461]; intracellular potassium ion homeostasis [GO:0030007]; membrane hyperpolarization [GO:0060081]; protein homooligomerization [GO:0051260]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0005737; GO:0005829; GO:0005886; GO:0030007; GO:0042802; GO:0051260; GO:0060081; GO:0090461
GN015735	GN015735.1	P22589	26.4	144	504	229	1.38e-11	67.8	UBIQP_PHYIN	Polyubiquitin [Cleaved into: Ubiquitin]	Phytophthora infestans (Potato late blight agent) (Botrytis infestans)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN015736	GN015736.1	A5D7J3	41.7	103	217	452	1.02e-12	69.7	KNOP1_BOVIN	Lysine-rich nucleolar protein 1 (Testis-specific gene 118 protein)	Bos taurus (Bovine)			nucleolus [GO:0005730]	GO:0005730
GN015743	GN015743.1	Q9CPX7	48.6	105	168	135	2.22e-32	115	RT16_MOUSE	Small ribosomal subunit protein bS16m (28S ribosomal protein S16, mitochondrial) (MRP-S16) (S16mt)	Mus musculus (Mouse)	mitochondrial translation [GO:0032543]	structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005763; GO:0005829; GO:0032543
GN015744	GN015744.1	A2YH60	40.9	154	219	419	6.12e-32	123	CCB22_ORYSI	Cyclin-B2-2 (CycOs2) (G2/mitotic-specific cyclin-B2-2) (CycB2;2)	Oryza sativa subsp. indica (Rice)	mitotic cell cycle phase transition [GO:0044772]; response to gamma radiation [GO:0010332]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	nucleus [GO:0005634]	GO:0005634; GO:0010332; GO:0016538; GO:0044772
GN015747	GN015747.1	A2YH60	40.9	154	219	419	4.40e-32	123	CCB22_ORYSI	Cyclin-B2-2 (CycOs2) (G2/mitotic-specific cyclin-B2-2) (CycB2;2)	Oryza sativa subsp. indica (Rice)	mitotic cell cycle phase transition [GO:0044772]; response to gamma radiation [GO:0010332]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	nucleus [GO:0005634]	GO:0005634; GO:0010332; GO:0016538; GO:0044772
GN015750	GN015750.1	Q62763	73.1	346	464	448	4.51e-170	488	KC1G3_RAT	Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1)	Rattus norvegicus (Rat)	endocytosis [GO:0006897]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004674; GO:0005524; GO:0005737; GO:0005886; GO:0006468; GO:0006897; GO:0046777; GO:0090263; GO:0106310
GN015751	GN015751.1	A0JN62	49.6	1020	1003	987	5.23e-294	845	CE120_BOVIN	Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100)	Bos taurus (Bovine)	centrosome cycle [GO:0007098]; interkinetic nuclear migration [GO:0022027]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of cilium assembly [GO:0045724]; positive regulation of establishment of protein localization [GO:1904951]		centriole [GO:0005814]; centrosome [GO:0005813]	GO:0005813; GO:0005814; GO:0007098; GO:0010825; GO:0022027; GO:0045724; GO:1903724; GO:1904951
GN015752	GN015752.1	Q75AC3	53.3	120	131	281	4.35e-45	150	CFD1_EREGS	Cytosolic Fe-S cluster assembly factor CFD1 (Cytosolic Fe-S cluster-deficient protein 1)	Eremothecium gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Ashbya gossypii)	iron-sulfur cluster assembly [GO:0016226]	4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent FeS chaperone activity [GO:0140663]	cytoplasm [GO:0005737]	GO:0005524; GO:0005737; GO:0016226; GO:0051539; GO:0140663
GN015753	GN015753.1	Q91XE9	57.1	154	551	479	4.07e-36	144	CR3L3_MOUSE	Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0005654; GO:0005783; GO:0005789; GO:0005829; GO:0006357; GO:0016020; GO:0034976; GO:0042802; GO:0042803; GO:0045944; GO:0046982
GN015754	GN015754.1	Q8IWL3	39.9	188	279	235	7.16e-32	120	HSC20_HUMAN	Iron-sulfur cluster co-chaperone protein HscB (DnaJ homolog subfamily C member 20) [Cleaved into: Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic (C-HSC20); Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]	Homo sapiens (Human)	[2Fe-2S] cluster assembly [GO:0044571]; iron-sulfur cluster assembly [GO:0016226]; primitive erythrocyte differentiation [GO:0060319]; primitive hemopoiesis [GO:0060215]; protein complex oligomerization [GO:0051259]	ATPase activator activity [GO:0001671]; identical protein binding [GO:0042802]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0001671; GO:0005737; GO:0005739; GO:0005829; GO:0016226; GO:0042802; GO:0044571; GO:0051087; GO:0051259; GO:0060215; GO:0060319
GN015755	GN015755.1	A0A1S4GHV7	27.8	320	355	493	2.06e-28	118	FUTA_ANOGA	Core alpha-(1,3)-fucosyltransferase (EC 2.4.1.214) (Fucosyltransferase A) (AgFucTA)	Anopheles gambiae (African malaria mosquito)	N-glycan processing [GO:0006491]	glycoprotein 3-alpha-L-fucosyltransferase activity [GO:0018392]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0018392; GO:0032580
GN015758	GN015758.1	Q9D6R2	73.5	230	723	366	8.35e-112	345	IDH3A_MOUSE	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)	Mus musculus (Mouse)	tricarboxylic acid cycle [GO:0006099]	isocitrate dehydrogenase (NAD+) activity [GO:0004449]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]	isocitrate dehydrogenase complex (NAD+) [GO:0045242]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]	GO:0000287; GO:0004449; GO:0005739; GO:0005759; GO:0006099; GO:0043209; GO:0045242; GO:0051287
GN015759	GN015759.1	Q61532	56.9	334	749	720	7.35e-117	371	MK06_MOUSE	Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3)	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; positive regulation of dendritic spine development [GO:0060999]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; septin cytoskeleton [GO:0032156]	GO:0004672; GO:0004707; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006468; GO:0019901; GO:0032156; GO:0032991; GO:0035556; GO:0046982; GO:0060999; GO:0106310
GN015760	GN015760.1	Q6PBX9	58.1	172	212	189	3.84e-64	199	REEP5_DANRE	Receptor expression-enhancing protein 5	Danio rerio (Zebrafish) (Brachydanio rerio)	endoplasmic reticulum membrane organization [GO:0090158]		endoplasmic reticulum membrane [GO:0005789]; sarcoplasmic reticulum membrane [GO:0033017]	GO:0005789; GO:0033017; GO:0090158
GN015761	GN015761.1	Q8IUZ0	47.7	568	1069	686	4.70e-69	248	LRC49_HUMAN	Leucine-rich repeat-containing protein 49 (Centriolar satellite-associated tubulin polyglutamylase complex regulator 2) (Tubulin polyglutamylase complex subunit 4) (PGs4)	Homo sapiens (Human)	microtubule cytoskeleton organization [GO:0000226]	protein-macromolecule adaptor activity [GO:0030674]	catalytic complex [GO:1902494]; centriolar satellite [GO:0034451]; microtubule [GO:0005874]	GO:0000226; GO:0005874; GO:0030674; GO:0034451; GO:1902494
GN015762	GN015762.1	P42574	35.8	151	305	277	3.40e-12	68.9	CASP3_HUMAN	Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]	Homo sapiens (Human)	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; axonal fasciculation [GO:0007413]; cellular response to staurosporine [GO:0072734]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; glial cell apoptotic process [GO:0034349]; hippocampus development [GO:0021766]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to osmotic stress [GO:0008627]; keratinocyte differentiation [GO:0030216]; learning or memory [GO:0007611]; leukocyte apoptotic process [GO:0071887]; luteolysis [GO:0001554]; negative regulation of cytokine production [GO:0001818]; neuron differentiation [GO:0030182]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet formation [GO:0030220]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of macroautophagy [GO:0016241]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647]; regulation of synaptic vesicle cycle [GO:0098693]; response to amino acid [GO:0043200]; response to anesthetic [GO:0072347]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to insulin-like growth factor stimulus [GO:1990418]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to tumor necrosis factor [GO:0034612]; response to X-ray [GO:0010165]; response to xenobiotic stimulus [GO:0009410]; striated muscle cell differentiation [GO:0051146]; swimming behavior [GO:0036269]; synapse pruning [GO:0098883]	aspartic-type endopeptidase activity [GO:0004190]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; cysteine-type endopeptidase activity [GO:0004197]; death receptor binding [GO:0005123]; enzyme activator activity [GO:0008047]; peptidase activity [GO:0008233]; phospholipase A2 activator activity [GO:0016005]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	GO:0001554; GO:0001666; GO:0001818; GO:0002020; GO:0004190; GO:0004197; GO:0004861; GO:0005123; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007413; GO:0007611; GO:0008047; GO:0008233; GO:0008627; GO:0009410; GO:0009749; GO:0010165; GO:0014069; GO:0016005; GO:0016241; GO:0016485; GO:0021766; GO:0030163; GO:0030182; GO:0030216; GO:0030218; GO:0030220; GO:0031264; GO:0031647; GO:0032025; GO:0032355; GO:0032496; GO:0032880; GO:0034349; GO:0034612; GO:0035094; GO:0036269; GO:0042542; GO:0043025; GO:0043200; GO:0043525; GO:0044877; GO:0045471; GO:0048011; GO:0051146; GO:0051384; GO:0051604; GO:0070269; GO:0071887; GO:0072347; GO:0072734; GO:0097190; GO:0097193; GO:0097194; GO:0098693; GO:0098883; GO:0098978; GO:0140639; GO:1902004; GO:1990418
GN015765	GN015765.1	Q9JLC8	25.3	4226	4148	4582	4.05e-299	1013	SACS_MOUSE	Sacsin (DnaJ homolog subfamily C member 29)	Mus musculus (Mouse)	negative regulation of inclusion body assembly [GO:0090084]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0090084
GN015767	GN015767.1	Q5ZIJ9	29.7	175	584	954	9.31e-10	65.5	MIB2_CHICK	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (RING-type E3 ubiquitin transferase MIB2)	Gallus gallus (Chicken)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN015768	GN015768.1	Q6GNY1	28.6	206	307	1011	2.06e-12	71.2	MIB1_XENLA	E3 ubiquitin-protein ligase mib1 (EC 2.3.2.27) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase mib1)	Xenopus laevis (African clawed frog)	endocytosis [GO:0006897]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]	GO:0005737; GO:0006897; GO:0007219; GO:0008270; GO:0016567; GO:0034451; GO:0061630
GN015773	GN015773.1	Q64373	31.6	152	225	233	1.31e-17	81.6	B2CL1_MOUSE	Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)	Mus musculus (Mouse)	apoptotic process in bone marrow cell [GO:0071839]; cell population proliferation [GO:0008283]; cellular response to alkaloid [GO:0071312]; cellular response to amino acid stimulus [GO:0071230]; cellular response to gamma radiation [GO:0071480]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fertilization [GO:0009566]; germ cell development [GO:0007281]; hepatocyte apoptotic process [GO:0097284]; in utero embryonic development [GO:0001701]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; male gonad development [GO:0008584]; mitochondrion organization [GO:0007005]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of execution phase of apoptosis [GO:1900118]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; neuron apoptotic process [GO:0051402]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic process [GO:0043065]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of synaptic vesicle clustering [GO:2000809]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of synaptic vesicle exocytosis [GO:2000302]; regulation of apoptotic process [GO:0042981]; regulation of cytokinesis [GO:0032465]; regulation of growth [GO:0040008]; regulation of long-term synaptic depression [GO:1900452]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of synaptic vesicle endocytosis [GO:1900242]; release of cytochrome c from mitochondria [GO:0001836]; response to cycloheximide [GO:0046898]; response to cytokine [GO:0034097]; response to ischemia [GO:0002931]; response to radiation [GO:0009314]; response to virus [GO:0009615]; spermatogenesis [GO:0007283]; synaptic vesicle recycling via endosome [GO:0036466]	BH domain binding [GO:0051400]; BH3 domain binding [GO:0051434]; channel activity [GO:0015267]; clathrin binding [GO:0030276]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]	Bcl-2 family protein complex [GO:0097136]; centrosome [GO:0005813]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; presynapse [GO:0098793]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	GO:0001541; GO:0001701; GO:0001836; GO:0002931; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005783; GO:0005813; GO:0005829; GO:0005905; GO:0007005; GO:0007281; GO:0007283; GO:0008021; GO:0008283; GO:0008284; GO:0008584; GO:0008630; GO:0009314; GO:0009566; GO:0009615; GO:0015267; GO:0016020; GO:0019901; GO:0030276; GO:0030672; GO:0031965; GO:0031966; GO:0032465; GO:0034097; GO:0036466; GO:0040008; GO:0042802; GO:0042981; GO:0043027; GO:0043065; GO:0043066; GO:0043524; GO:0044877; GO:0046898; GO:0046902; GO:0051020; GO:0051400; GO:0051402; GO:0051434; GO:0051607; GO:0051881; GO:0071230; GO:0071312; GO:0071480; GO:0071839; GO:0090201; GO:0097136; GO:0097192; GO:0097284; GO:0097371; GO:0098793; GO:1900118; GO:1900242; GO:1900244; GO:1900452; GO:1901029; GO:1902042; GO:1902230; GO:1902236; GO:1903077; GO:2000302; GO:2000809; GO:2000811; GO:2001171; GO:2001243
GN015774	GN015774.1	Q1HRV8	46.8	250	278	358	3.50e-80	249	ELVL1_AEDAE	Very long chain fatty acid elongase AAEL008004 (EC 2.3.1.199) (3-keto acyl-CoA synthase AAEL008004) (Elongation of very long chain fatty acids protein AAEL008004) (Very-long-chain 3-oxoacyl-CoA synthase AAEL008004)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761]	fatty acid elongase activity [GO:0009922]	endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0009922; GO:0019367; GO:0030148; GO:0034625; GO:0034626; GO:0042761
GN015775	GN015775.1	P16537	38.5	91	457	208	2.14e-17	84.0	SPC3_STRPU	Protein SPEC3	Strongylocentrotus purpuratus (Purple sea urchin)			cilium [GO:0005929]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005929
GN015780	GN015780.1	Q8IY18	49.0	51	59	1101	1.61e-10	57.4	SMC5_HUMAN	Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)	Homo sapiens (Human)	cellular senescence [GO:0090398]; chromatin looping [GO:0140588]; DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; host-mediated suppression of viral genome replication [GO:0044828]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]; telomere maintenance via recombination [GO:0000722]	ATP hydrolysis activity [GO:0016887]; DNA secondary structure binding [GO:0000217]; single-stranded DNA binding [GO:0003697]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; interchromatin granule [GO:0035061]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; sex chromosome [GO:0000803]; site of double-strand break [GO:0035861]; Smc5-Smc6 complex [GO:0030915]	GO:0000217; GO:0000722; GO:0000724; GO:0000781; GO:0000803; GO:0003697; GO:0005634; GO:0005654; GO:0005694; GO:0006974; GO:0016605; GO:0016607; GO:0016887; GO:0016925; GO:0030915; GO:0032204; GO:0034184; GO:0035061; GO:0035861; GO:0044828; GO:0051984; GO:0090398; GO:0140588
GN015784	GN015784.1	Q5RJN4	55.1	69	146	163	8.71e-24	93.6	SHFL_RAT	Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog (SHFL) (Repressor of yield of DENV protein homolog) (RyDEN)	Rattus norvegicus (Rat)	defense response to virus [GO:0051607]; negative regulation of translational frameshifting [GO:2001125]; negative regulation of viral genome replication [GO:0045071]; regulation of translational termination [GO:0006449]; response to interferon-beta [GO:0035456]; response to type I interferon [GO:0034340]; response to type II interferon [GO:0034341]; response to type III interferon [GO:0034342]; viral translational frameshifting [GO:0075523]	identical protein binding [GO:0042802]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]	GO:0000932; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006449; GO:0034340; GO:0034341; GO:0034342; GO:0035456; GO:0042802; GO:0043022; GO:0045071; GO:0051607; GO:0075523; GO:1990825; GO:2001125
GN015785	GN015785.1	Q7YTC2	37.3	150	145	322	2.90e-13	68.6	OTP_SACKO	Homeobox protein orthopedia	Saccoglossus kowalevskii (Acorn worm)	neuron differentiation [GO:0030182]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	nucleus [GO:0005634]	GO:0000981; GO:0003677; GO:0005634; GO:0030182
GN015789	GN015789.1	Q5ZJ01	81.2	271	479	288	5.42e-167	475	AB17B_CHICK	Alpha/beta hydrolase domain-containing protein 17B (Abhydrolase domain-containing protein 17B) (EC 3.1.2.22)	Gallus gallus (Chicken)	negative regulation of protein localization to microtubule [GO:1902817]; positive regulation of protein localization to endosome [GO:1905668]; regulation of dendritic spine maintenance [GO:1902950]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization to synapse [GO:1902473]	palmitoyl-(protein) hydrolase activity [GO:0008474]	dendritic spine [GO:0043197]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; recycling endosome membrane [GO:0055038]	GO:0005886; GO:0008474; GO:0010008; GO:0043197; GO:0055038; GO:0098839; GO:0099175; GO:1902473; GO:1902817; GO:1902950; GO:1905668
GN015790	GN015790.1	Q9CQ90	50.9	106	205	155	1.62e-32	117	CI085_MOUSE	Uncharacterized protein C9orf85 homolog	Mus musculus (Mouse)				
GN015791	GN015791.1	O35094	42.8	283	445	453	7.08e-75	244	TIM44_RAT	Mitochondrial import inner membrane translocase subunit TIM44	Rattus norvegicus (Rat)	cardiac muscle cell differentiation [GO:0055007]; intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150]; response to 3,3',5-triiodo-L-thyronine [GO:1905242]	protein-folding chaperone binding [GO:0051087]; protein-macromolecule adaptor activity [GO:0030674]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; PAM complex, Tim23 associated import motor [GO:0001405]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	GO:0001405; GO:0005739; GO:0005743; GO:0005744; GO:0005759; GO:0006886; GO:0030150; GO:0030674; GO:0051087; GO:0055007; GO:1905242
GN015792	GN015792.1	Q9D1I5	63.8	160	167	178	6.47e-68	207	MCEE_MOUSE	Methylmalonyl-CoA epimerase, mitochondrial (EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)	Mus musculus (Mouse)	L-methylmalonyl-CoA metabolic process [GO:0046491]; succinyl-CoA biosynthetic process [GO:1901290]	methylmalonyl-CoA epimerase activity [GO:0004493]	mitochondrion [GO:0005739]	GO:0004493; GO:0005739; GO:0046491; GO:1901290
GN015798	GN015798.1	P0AFQ9	29.5	210	835	265	3.13e-12	71.2	YCFH_ECO57	Uncharacterized metal-dependent hydrolase YcfH (EC 3.1.-.-)	Escherichia coli O157:H7		DNA nuclease activity [GO:0004536]; hydrolase activity, acting on ester bonds [GO:0016788]	cytosol [GO:0005829]	GO:0004536; GO:0005829; GO:0016788
GN015803	GN015803.1	Q9CR78	31.3	99	152	275	4.07e-10	59.7	MSD3_MOUSE	Myb/SANT-like DNA-binding domain-containing protein 3	Mus musculus (Mouse)				
GN015806	GN015806.1	Q9ES45	41.3	1195	1209	1517	9.42e-289	858	DUOX2_RAT	Dual oxidase 2 (EC 1.-.-.-) (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase THOX2) (Thyroid oxidase 2)	Rattus norvegicus (Rat)	adenohypophysis morphogenesis [GO:0048855]; bone mineralization [GO:0030282]; cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; fertilization [GO:0009566]; hormone metabolic process [GO:0042445]; hydrogen peroxide biosynthetic process [GO:0050665]; inner ear development [GO:0048839]; multicellular organism growth [GO:0035264]; positive regulation of cell motility [GO:2000147]; positive regulation of wound healing [GO:0090303]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; response to virus [GO:0009615]; superoxide anion generation [GO:0042554]; thyroid gland development [GO:0030878]; thyroid hormone generation [GO:0006590]; thyroid hormone metabolic process [GO:0042403]	calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; peroxidase activity [GO:0004601]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]	anchoring junction [GO:0070161]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]	GO:0004601; GO:0005509; GO:0005783; GO:0005829; GO:0005886; GO:0006590; GO:0006952; GO:0006979; GO:0009566; GO:0009615; GO:0009986; GO:0016174; GO:0016175; GO:0016324; GO:0019221; GO:0020037; GO:0030282; GO:0030878; GO:0031252; GO:0035264; GO:0042335; GO:0042403; GO:0042445; GO:0042554; GO:0043020; GO:0045177; GO:0048839; GO:0048855; GO:0050665; GO:0051591; GO:0070161; GO:0090303; GO:2000147
GN015809	GN015809.1	Q6PGE7	43.7	586	627	637	8.07e-167	493	SC6A7_MOUSE	Sodium-dependent proline transporter (Solute carrier family 6 member 7)	Mus musculus (Mouse)	glycine import across plasma membrane [GO:1903804]; proline transmembrane transport [GO:0035524]; proline transport [GO:0015824]; protein catabolic process [GO:0030163]; sodium ion transmembrane transport [GO:0035725]	L-proline transmembrane transporter activity [GO:0015193]; proline:sodium symporter activity [GO:0005298]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; synaptic vesicle membrane [GO:0030672]	GO:0005298; GO:0005886; GO:0015193; GO:0015824; GO:0030163; GO:0030672; GO:0035524; GO:0035725; GO:0042734; GO:0045202; GO:0097060; GO:0098685; GO:0098978; GO:1903804
GN015813	GN015813.1	B3EWZ6	31.9	357	362	7311	2.34e-38	149	MLRP2_ACRMI	MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN015814	GN015814.1	Q9QXT0	41.0	156	220	182	6.17e-34	122	CNPY2_MOUSE	Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein ZSIG9) (Transmembrane protein 4)	Mus musculus (Mouse)	negative regulation of gene expression [GO:0010629]; regulation of low-density lipoprotein particle clearance [GO:0010988]		endoplasmic reticulum [GO:0005783]	GO:0005783; GO:0010629; GO:0010988
GN015816	GN015816.1	A6QQL9	64.4	87	96	110	4.20e-31	108	SRP14_BOVIN	Signal recognition particle 14 kDa protein (SRP14)	Bos taurus (Bovine)	SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]	cytosol [GO:0005829]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]	GO:0005786; GO:0005829; GO:0006616; GO:0008312; GO:0030942
GN015818	GN015818.1	O95198	26.0	308	621	593	5.48e-27	119	KLHL2_HUMAN	Kelch-like protein 2 (Actin-binding protein Mayven)	Homo sapiens (Human)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	actin binding [GO:0003779]; identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	actin cytoskeleton [GO:0015629]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; ruffle [GO:0001726]	GO:0001726; GO:0003779; GO:0005737; GO:0005829; GO:0015629; GO:0016567; GO:0030027; GO:0031463; GO:0042802; GO:0043161; GO:1990756
GN015819	GN015819.1	Q16975	70.0	754	741	743	0.0	1047	KPC2_APLCA	Calcium-independent protein kinase C (EC 2.7.11.13) (APL II)	Aplysia californica (California sea hare)	learning or memory [GO:0007611]	ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; protein serine kinase activity [GO:0106310]	membrane [GO:0016020]	GO:0004697; GO:0005524; GO:0007611; GO:0016020; GO:0106310
GN015820	GN015820.1	Q3T0V9	67.1	319	319	318	3.91e-155	439	DEOC_BOVIN	Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase)	Bos taurus (Bovine)	2'-deoxyribonucleoside catabolic process [GO:0046121]; deoxyribonucleotide catabolic process [GO:0009264]; deoxyribose phosphate catabolic process [GO:0046386]	deoxyribose-phosphate aldolase activity [GO:0004139]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0004139; GO:0005654; GO:0005737; GO:0009264; GO:0046121; GO:0046386
GN015821	GN015821.1	Q2TBG7	59.6	104	112	152	5.71e-44	143	ISCA2_BOVIN	Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1)	Bos taurus (Bovine)	iron-sulfur cluster assembly [GO:0016226]; protein maturation [GO:0051604]	2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]	mitochondrial [4Fe-4S] assembly complex [GO:0120510]; mitochondrion [GO:0005739]	GO:0005506; GO:0005739; GO:0016226; GO:0051537; GO:0051539; GO:0051604; GO:0120510
GN015822	GN015822.1	A8C752	26.6	301	756	1953	2.49e-12	74.7	THADA_CHLAE	tRNA (32-2'-O)-methyltransferase regulator THADA (Thyroid adenoma-associated protein homolog)	Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)	tRNA nucleoside ribose methylation [GO:0002128]		cytosol [GO:0005829]	GO:0002128; GO:0005829
GN015823	GN015823.1	O00471	51.9	709	714	708	6.13e-250	711	EXOC5_HUMAN	Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10)	Homo sapiens (Human)	exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; kidney development [GO:0001822]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; exocyst [GO:0000145]; midbody [GO:0030496]	GO:0000145; GO:0000281; GO:0001822; GO:0005737; GO:0005829; GO:0006887; GO:0006892; GO:0006893; GO:0006904; GO:0030496; GO:0031267; GO:0072659; GO:0090148; GO:0090522
GN015824	GN015824.1	Q6DBR9	46.2	106	228	182	3.61e-24	97.8	KXDL1_DANRE	KxDL motif-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	lysosome localization [GO:0032418]; vesicle-mediated transport [GO:0016192]		BORC complex [GO:0099078]; lysosomal membrane [GO:0005765]	GO:0005765; GO:0016192; GO:0032418; GO:0099078
GN015827	GN015827.1	Q8TDJ6	45.6	169	192	3036	3.84e-42	154	DMXL2_HUMAN	DmX-like protein 2 (Rabconnectin-3)	Homo sapiens (Human)	vacuolar acidification [GO:0007035]	small GTPase binding [GO:0031267]	extracellular region [GO:0005576]; neuronal dense core vesicle [GO:0098992]; RAVE complex [GO:0043291]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	GO:0005576; GO:0007035; GO:0008021; GO:0030672; GO:0031267; GO:0043291; GO:0098992
GN015828	GN015828.1	Q8TDJ6	34.5	2207	2198	3036	6.58e-309	982	DMXL2_HUMAN	DmX-like protein 2 (Rabconnectin-3)	Homo sapiens (Human)	vacuolar acidification [GO:0007035]	small GTPase binding [GO:0031267]	extracellular region [GO:0005576]; neuronal dense core vesicle [GO:0098992]; RAVE complex [GO:0043291]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	GO:0005576; GO:0007035; GO:0008021; GO:0030672; GO:0031267; GO:0043291; GO:0098992
GN015829	GN015829.1	Q8TDJ6	38.6	132	133	3036	1.04e-16	78.6	DMXL2_HUMAN	DmX-like protein 2 (Rabconnectin-3)	Homo sapiens (Human)	vacuolar acidification [GO:0007035]	small GTPase binding [GO:0031267]	extracellular region [GO:0005576]; neuronal dense core vesicle [GO:0098992]; RAVE complex [GO:0043291]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	GO:0005576; GO:0007035; GO:0008021; GO:0030672; GO:0031267; GO:0043291; GO:0098992
GN015830	GN015830.1	Q8BPN8	42.1	121	136	3032	1.51e-18	84.0	DMXL2_MOUSE	DmX-like protein 2 (Rabconnectin-3)	Mus musculus (Mouse)	brain development [GO:0007420]; chemical synaptic transmission [GO:0007268]; corpus callosum development [GO:0022038]; glucose homeostasis [GO:0042593]; sensory perception of smell [GO:0007608]; spermatogenesis [GO:0007283]; vacuolar acidification [GO:0007035]	small GTPase binding [GO:0031267]	neuronal dense core vesicle [GO:0098992]; RAVE complex [GO:0043291]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	GO:0007035; GO:0007268; GO:0007283; GO:0007420; GO:0007608; GO:0008021; GO:0022038; GO:0030672; GO:0031267; GO:0042593; GO:0043291; GO:0098992
GN015831	GN015831.1	Q6PNC0	54.7	139	150	3013	4.47e-48	169	DMXL1_MOUSE	DmX-like protein 1 (X-like 1 protein)	Mus musculus (Mouse)	proton-transporting V-type ATPase complex assembly [GO:0070070]; regulation of protein localization [GO:0032880]; vacuolar acidification [GO:0007035]		endomembrane system [GO:0012505]; RAVE complex [GO:0043291]; secretory vesicle [GO:0099503]	GO:0007035; GO:0012505; GO:0032880; GO:0043291; GO:0070070; GO:0099503
GN015834	GN015834.1	H2A0L1	31.6	358	657	456	7.90e-32	132	TYRO2_PINMG	Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2)	Margaritifera margaritifera (Freshwater pearl mussel)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN015835	GN015835.1	H2A0L1	31.1	373	657	456	2.35e-32	134	TYRO2_PINMG	Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2)	Margaritifera margaritifera (Freshwater pearl mussel)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN015836	GN015836.1	H2A0L1	31.9	367	658	456	1.20e-30	129	TYRO2_PINMG	Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2)	Margaritifera margaritifera (Freshwater pearl mussel)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN015838	GN015838.1	Q8R1B8	27.5	447	496	470	5.34e-32	131	RORB_MOUSE	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)	Mus musculus (Mouse)	amacrine cell differentiation [GO:0035881]; cellular response to retinoic acid [GO:0071300]; eye photoreceptor cell development [GO:0042462]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; retinal rod cell differentiation [GO:0060221]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; melatonin receptor activity [GO:0008502]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0004879; GO:0005634; GO:0005654; GO:0006357; GO:0008270; GO:0008502; GO:0035881; GO:0042462; GO:0042752; GO:0043565; GO:0045668; GO:0045892; GO:0045893; GO:0045944; GO:0046548; GO:0046549; GO:0060041; GO:0060221; GO:0071300; GO:1990837
GN015839	GN015839.1	P00182	36.8	288	288	489	6.55e-65	214	CP2C3_RABIT	Cytochrome P450 2C3 (EC 1.14.14.1) (CYPIIC3) (Cytochrome P450 PBc3) (Cytochrome P450 form 3B)	Oryctolagus cuniculus (Rabbit)	xenobiotic metabolic process [GO:0006805]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005789; GO:0006805; GO:0016712; GO:0020037
GN015841	GN015841.1	Q15751	70.8	667	680	4861	3.67e-315	960	HERC1_HUMAN	Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619)	Homo sapiens (Human)	protein ubiquitination [GO:0016567]	guanyl-nucleotide exchange factor activity [GO:0005085]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0005085; GO:0005737; GO:0005794; GO:0005829; GO:0016020; GO:0016567; GO:0061630
GN015845	GN015845.1	Q8R2K4	47.6	382	808	616	7.72e-101	328	TAF6L_MOUSE	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) (PCAF-associated factor 65-alpha) (PAF65-alpha)	Mus musculus (Mouse)	positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of somatic stem cell population maintenance [GO:1904672]; RNA polymerase II preinitiation complex assembly [GO:0051123]	protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription coactivator activity [GO:0003713]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669]	GO:0000124; GO:0003713; GO:0005634; GO:0005654; GO:0005669; GO:0006282; GO:0006355; GO:0016251; GO:0043484; GO:0045893; GO:0046695; GO:0046982; GO:0051123; GO:1904672
GN015851	GN015851.1	P07686	54.5	123	128	556	1.29e-40	144	HEXB_HUMAN	Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]	Homo sapiens (Human)	astrocyte cell migration [GO:0043615]; carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan catabolic process [GO:0030207]; dermatan sulfate proteoglycan catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; N-acetylglucosamine metabolic process [GO:0006044]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell shape [GO:0008360]; single fertilization [GO:0007338]	acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylglucosaminidase activity [GO:0016231]; beta-N-acetylhexosaminidase activity [GO:0004563]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; beta-N-acetylhexosaminidase complex [GO:1905379]; cortical granule [GO:0060473]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]	GO:0001669; GO:0004563; GO:0005576; GO:0005764; GO:0005975; GO:0006044; GO:0006689; GO:0007338; GO:0008360; GO:0008375; GO:0016020; GO:0016231; GO:0030203; GO:0030207; GO:0030209; GO:0030214; GO:0030246; GO:0035578; GO:0042582; GO:0042802; GO:0043202; GO:0043615; GO:0044877; GO:0045944; GO:0060473; GO:0070062; GO:1905379
GN015852	GN015852.1	Q9HAD4	29.5	441	449	459	7.58e-47	171	WDR41_HUMAN	WD repeat-containing protein 41	Homo sapiens (Human)	negative regulation of exocytosis [GO:0045920]; negative regulation of immune response [GO:0050777]; regulation of autophagy [GO:0010506]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor complex [GO:0032045]; lysosomal membrane [GO:0005765]	GO:0005096; GO:0005737; GO:0005765; GO:0010506; GO:0032045; GO:0045920; GO:0050777
GN015856	GN015856.1	Q9LQV2	41.1	772	1950	1107	1.53e-145	484	RDR1_ARATH	RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1)	Arabidopsis thaliana (Mouse-ear cress)	positive regulation of post-transcriptional gene silencing [GO:0060148]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; siRNA processing [GO:0030422]; wax biosynthetic process [GO:0010025]	nucleic acid binding [GO:0003676]; RNA-directed RNA polymerase activity [GO:0003968]	nuclear RNA-directed RNA polymerase complex [GO:0031380]; nucleus [GO:0005634]	GO:0003676; GO:0003968; GO:0005634; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0031380; GO:0060148
GN015858	GN015858.1	Q9LQV2	29.9	394	508	1107	4.50e-28	122	RDR1_ARATH	RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1)	Arabidopsis thaliana (Mouse-ear cress)	positive regulation of post-transcriptional gene silencing [GO:0060148]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; siRNA processing [GO:0030422]; wax biosynthetic process [GO:0010025]	nucleic acid binding [GO:0003676]; RNA-directed RNA polymerase activity [GO:0003968]	nuclear RNA-directed RNA polymerase complex [GO:0031380]; nucleus [GO:0005634]	GO:0003676; GO:0003968; GO:0005634; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0031380; GO:0060148
GN015859	GN015859.1	Q9LQV2	42.3	428	1195	1107	6.10e-86	306	RDR1_ARATH	RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1)	Arabidopsis thaliana (Mouse-ear cress)	positive regulation of post-transcriptional gene silencing [GO:0060148]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; siRNA processing [GO:0030422]; wax biosynthetic process [GO:0010025]	nucleic acid binding [GO:0003676]; RNA-directed RNA polymerase activity [GO:0003968]	nuclear RNA-directed RNA polymerase complex [GO:0031380]; nucleus [GO:0005634]	GO:0003676; GO:0003968; GO:0005634; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0031380; GO:0060148
GN015860	GN015860.1	Q9LQV2	39.6	761	1611	1107	1.12e-131	441	RDR1_ARATH	RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1)	Arabidopsis thaliana (Mouse-ear cress)	positive regulation of post-transcriptional gene silencing [GO:0060148]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; siRNA processing [GO:0030422]; wax biosynthetic process [GO:0010025]	nucleic acid binding [GO:0003676]; RNA-directed RNA polymerase activity [GO:0003968]	nuclear RNA-directed RNA polymerase complex [GO:0031380]; nucleus [GO:0005634]	GO:0003676; GO:0003968; GO:0005634; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0031380; GO:0060148
GN015862	GN015862.1	P49578	30.2	179	329	639	1.85e-09	62.4	ACM3_CHICK	Muscarinic acetylcholine receptor M3	Gallus gallus (Chicken)	adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smooth muscle contraction [GO:0045987]; saliva secretion [GO:0046541]	G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0004930; GO:0005886; GO:0016907; GO:0043410; GO:0045211; GO:0045987; GO:0046541; GO:0071880
GN015863	GN015863.1	Q6AYP4	44.8	145	603	525	3.09e-31	131	ZC21C_RAT	Zinc finger C2HC domain-containing protein 1C	Rattus norvegicus (Rat)				
GN015864	GN015864.1	Q02338	46.8	267	356	343	4.49e-70	225	BDH_HUMAN	D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH) (Short chain dehydrogenase/reductase family 9C member 1)	Homo sapiens (Human)	ketone biosynthetic process [GO:0042181]; ketone catabolic process [GO:0042182]	3-hydroxybutyrate dehydrogenase activity [GO:0003858]	matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003858; GO:0005739; GO:0005743; GO:0005759; GO:0042181; GO:0042182; GO:0099617
GN015865	GN015865.1	Q8BJ25	37.9	95	137	218	2.29e-12	64.7	THAP3_MOUSE	THAP domain-containing protein 3	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]			GO:0045944
GN015870	GN015870.1	A1L3F4	45.2	549	522	507	4.26e-115	352	MEX3B_XENLA	RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3)	Xenopus laevis (African clawed frog)		RNA binding [GO:0003723]	nucleus [GO:0005634]; P-body [GO:0000932]	GO:0000932; GO:0003723; GO:0005634
GN015874	GN015874.1	A7M7C7	75.0	204	528	1008	2.64e-103	335	SKOR2_MOUSE	SKI family transcriptional corepressor 2 (Fussel-18 homolog) (LBX1 corepressor 1-like protein) (Ladybird homeobox corepressor 1-like protein) (Transcriptional corepressor Corl2)	Mus musculus (Mouse)	cell development [GO:0048468]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellum morphogenesis [GO:0021587]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cerebellar granule cell precursor proliferation [GO:0021936]; regulation of dendrite morphogenesis [GO:0048814]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000978; GO:0000981; GO:0003682; GO:0005634; GO:0005667; GO:0005737; GO:0021587; GO:0021702; GO:0021936; GO:0030512; GO:0030514; GO:0042826; GO:0045880; GO:0046332; GO:0048468; GO:0048814; GO:1990837
GN015876	GN015876.1	A0AVT1	52.4	1016	1018	1052	0.0	1044	UBA6_HUMAN	Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)	Homo sapiens (Human)	DNA damage response [GO:0006974]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	FAT10 activating enzyme activity [GO:0019780]; ubiquitin activating enzyme activity [GO:0004839]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004839; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006511; GO:0006974; GO:0016567; GO:0019780
GN015877	GN015877.1	O45782	27.6	254	359	426	1.11e-15	81.3	ARD17_CAEEL	Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1)	Caenorhabditis elegans		molecular adaptor activity [GO:0060090]; protein phosphatase 2B binding [GO:0030346]	cytoplasm [GO:0005737]	GO:0005737; GO:0030346; GO:0060090
GN015879	GN015879.1	P15043	43.7	71	118	609	5.76e-10	58.5	RECQ_ECOLI	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Escherichia coli (strain K12)	DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; G-quadruplex unwinding activity [GO:0160225]; single-stranded DNA helicase activity [GO:0017116]; transition metal ion binding [GO:0046914]; zinc ion binding [GO:0008270]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]; single-stranded DNA-dependent ATP-dependent DNA helicase complex [GO:0017117]	GO:0003677; GO:0003678; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0006974; GO:0008094; GO:0008270; GO:0009432; GO:0016887; GO:0017116; GO:0017117; GO:0030894; GO:0043138; GO:0043590; GO:0046914; GO:0160225
GN015883	GN015883.1	Q28113	31.1	293	335	344	7.41e-30	119	FUT2_BOVIN	Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Secretor factor) (Se) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)	Bos taurus (Bovine)	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; protein O-linked glycosylation via fucose [GO:0036066]	alpha-(1,2)-fucosyltransferase activity [GO:0031127]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]	GO:0005794; GO:0005975; GO:0008107; GO:0009101; GO:0031127; GO:0032580; GO:0036066
GN015885	GN015885.1	Q93075	31.3	163	426	761	1.15e-12	73.6	TATD2_HUMAN	3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2)	Homo sapiens (Human)		hydrolase activity, acting on ester bonds [GO:0016788]	nucleoplasm [GO:0005654]	GO:0005654; GO:0016788
GN015887	GN015887.1	Q05688	52.6	492	682	640	6.10e-168	498	IGF1R_BOVIN	Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]	Bos taurus (Bovine)	cellular response to glucose stimulus [GO:0071333]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of apoptotic process [GO:0043066]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein autophosphorylation [GO:0046777]; regulation of JNK cascade [GO:0046328]	ATP binding [GO:0005524]; insulin receptor activity [GO:0005009]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor binding [GO:0005520]; insulin-like growth factor receptor activity [GO:0005010]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein tyrosine kinase activity [GO:0004713]; structural molecule activity [GO:0005198]	axon [GO:0030424]; cytoplasm [GO:0005737]; insulin receptor complex [GO:0005899]; plasma membrane [GO:0005886]	GO:0004713; GO:0005009; GO:0005010; GO:0005198; GO:0005520; GO:0005524; GO:0005737; GO:0005886; GO:0005899; GO:0008286; GO:0030424; GO:0043066; GO:0043409; GO:0043410; GO:0043548; GO:0043560; GO:0046328; GO:0046777; GO:0048009; GO:0051897; GO:0071333
GN015891	GN015891.1	Q867B0	45.8	142	591	258	7.88e-28	115	CELA1_CANLF	Chymotrypsin-like elastase family member 1 (EC 3.4.21.36) (Elastase-1)	Canis lupus familiaris (Dog) (Canis familiaris)	inflammatory response [GO:0006954]; proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]	GO:0004252; GO:0005576; GO:0006508; GO:0006954
GN015892	GN015892.1	Q7Z401	38.8	2073	2002	1863	0.0	1164	MYCPP_HUMAN	C-myc promoter-binding protein (DENN domain-containing protein 4A)	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]; regulation of Rab protein signal transduction [GO:0032483]	DNA binding [GO:0003677]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003677; GO:0005085; GO:0005634; GO:0005829; GO:0006355; GO:0032483
GN015893	GN015893.1	Q92820	51.0	153	688	318	2.68e-37	145	GGH_HUMAN	Gamma-glutamyl hydrolase (EC 3.4.19.9) (Conjugase) (GH) (Gamma-Glu-X carboxypeptidase)	Homo sapiens (Human)		exopeptidase activity [GO:0008238]; gamma-glutamyl-peptidase activity [GO:0034722]; omega peptidase activity [GO:0008242]	azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosome [GO:0005764]; melanosome [GO:0042470]; nucleus [GO:0005634]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]	GO:0005576; GO:0005634; GO:0005764; GO:0005783; GO:0008238; GO:0008242; GO:0034722; GO:0035578; GO:0035580; GO:0042470; GO:0070062; GO:1904724
GN015895	GN015895.1	Q9UGM3	25.5	1950	2021	2413	4.98e-129	456	DMBT1_HUMAN	Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Deleted in malignant brain tumors 1 protein) (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein)	Homo sapiens (Human)	defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]	calcium-dependent protein binding [GO:0048306]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]; phagocytic vesicle membrane [GO:0030670]; zymogen granule membrane [GO:0042589]	GO:0005044; GO:0005576; GO:0005737; GO:0030670; GO:0030855; GO:0031012; GO:0035375; GO:0038187; GO:0042589; GO:0043152; GO:0045087; GO:0048306; GO:0050829; GO:0050830; GO:0070062; GO:0140144
GN015896	GN015896.1	P86789	35.8	229	488	302	1.03e-36	140	GIGA6_MAGGI	Gigasin-6	Magallana gigas (Pacific oyster) (Crassostrea gigas)			membrane [GO:0016020]	GO:0016020
GN015900	GN015900.1	Q6AZB8	26.8	168	154	349	2.27e-13	69.3	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN015901	GN015901.1	Q9CR78	31.9	94	97	275	1.91e-09	55.8	MSD3_MOUSE	Myb/SANT-like DNA-binding domain-containing protein 3	Mus musculus (Mouse)				
GN015904	GN015904.1	A4QNC6	36.0	136	141	138	1.62e-28	104	TIMCC_XENTR	TIM double twin CX3C motif protein	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			mitochondrial intermembrane space [GO:0005758]	GO:0005758
GN015905	GN015905.1	Q14147	49.2	1131	1224	1143	0.0	1006	DHX34_HUMAN	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) (DExH-box helicase 34)	Homo sapiens (Human)	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of phosphorylation [GO:0042327]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	membrane [GO:0016020]	GO:0000184; GO:0000956; GO:0003723; GO:0003724; GO:0004386; GO:0005524; GO:0016020; GO:0016887; GO:0042327; GO:0044877; GO:2000623
GN015907	GN015907.1	Q5ZJM3	47.7	197	214	651	4.60e-50	175	NGLY1_CHICK	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase)	Gallus gallus (Chicken)	glycoprotein catabolic process [GO:0006516]; positive regulation of BMP signaling pathway [GO:0030513]	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [GO:0000224]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000224; GO:0005634; GO:0005737; GO:0006516; GO:0030513
GN015908	GN015908.1	Q503I8	56.4	289	296	644	1.05e-114	347	NGLY1_DANRE	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase)	Danio rerio (Zebrafish) (Brachydanio rerio)	glycoprotein catabolic process [GO:0006516]; peripheral nervous system neuron axonogenesis [GO:0048936]; positive regulation of BMP signaling pathway [GO:0030513]; regulation of protein catabolic process [GO:0042176]; regulation of protein folding [GO:1903332]; skeletal muscle tissue development [GO:0007519]; swimming behavior [GO:0036269]	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [GO:0000224]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000224; GO:0005634; GO:0005737; GO:0006516; GO:0007519; GO:0030513; GO:0036269; GO:0042176; GO:0048936; GO:1903332
GN015909	GN015909.1	Q8NEF3	41.4	444	488	446	1.16e-84	271	CC112_HUMAN	Coiled-coil domain-containing protein 112 (Mutated in bladder cancer protein 1)	Homo sapiens (Human)			centriolar satellite [GO:0034451]	GO:0034451
GN015910	GN015910.1	P50143	72.1	549	554	547	1.14e-287	794	TCPG_XENLA	T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma)	Xenopus laevis (African clawed frog)	protein folding [GO:0006457]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]	chaperonin-containing T-complex [GO:0005832]	GO:0005524; GO:0005832; GO:0006457; GO:0016887; GO:0140662
GN015911	GN015911.1	Q63616	47.9	601	589	617	1.75e-188	546	VP33B_RAT	Vacuolar protein sorting-associated protein 33B (r-vps33b)	Rattus norvegicus (Rat)	collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; megakaryocyte development [GO:0035855]; melanosome localization [GO:0032400]; membrane fusion [GO:0061025]; peptidyl-lysine hydroxylation [GO:0017185]; platelet alpha granule organization [GO:0070889]; protein transport [GO:0015031]; regulation of platelet aggregation [GO:0090330]; skin morphogenesis [GO:0043589]; vesicle-mediated transport [GO:0016192]	protein-containing complex binding [GO:0044877]	clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule [GO:0031091]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]	GO:0005737; GO:0005764; GO:0005765; GO:0005768; GO:0005769; GO:0005770; GO:0005794; GO:0006886; GO:0007032; GO:0008021; GO:0015031; GO:0016192; GO:0017185; GO:0030136; GO:0030199; GO:0030897; GO:0031091; GO:0031901; GO:0031902; GO:0032400; GO:0032418; GO:0032963; GO:0035855; GO:0043589; GO:0044877; GO:0048471; GO:0055037; GO:0061025; GO:0070889; GO:0090330
GN015912	GN015912.1	Q9H8W5	24.9	437	612	580	7.84e-14	78.2	TRI45_HUMAN	E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99)	Homo sapiens (Human)	negative regulation of inflammatory response [GO:0050728]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0005829; GO:0008270; GO:0043161; GO:0050728; GO:0061630; GO:0070936
GN015914	GN015914.1	V5NAL9	44.0	273	299	899	2.71e-63	217	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN015915	GN015915.1	Q13263	26.8	276	632	835	1.63e-11	71.2	TIF1B_HUMAN	Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of type I interferon production [GO:0032481]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; promoter-specific chromatin binding [GO:1990841]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000785; GO:0000791; GO:0000792; GO:0001837; GO:0003677; GO:0003682; GO:0003713; GO:0003714; GO:0003723; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0006281; GO:0006325; GO:0006346; GO:0006974; GO:0008270; GO:0016567; GO:0016925; GO:0019789; GO:0031625; GO:0032481; GO:0032991; GO:0035851; GO:0042307; GO:0043124; GO:0043161; GO:0044790; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0061630; GO:0061665; GO:0070087; GO:0090575; GO:0140374; GO:0140463; GO:1990841
GN015916	GN015916.1	V5NAL9	51.9	135	136	899	1.10e-35	132	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN015917	GN015917.1	V5NAL9	44.8	424	432	899	1.26e-96	312	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN015918	GN015918.1	P10533	35.0	234	595	367	3.33e-36	142	RMIL_AVII1	Serine/threonine-protein kinase-transforming protein Rmil (EC 2.7.11.1)	Avian retrovirus IC10		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]		GO:0004674; GO:0005524; GO:0106310
GN015919	GN015919.1	Q3LSS0	47.4	78	113	961	1.16e-18	83.2	C19L2_DANRE	Pre-mRNA splicing factor cwf19l2 (CWF19-like protein 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	mRNA splicing, via spliceosome [GO:0000398]		post-mRNA release spliceosomal complex [GO:0071014]	GO:0000398; GO:0071014
GN015920	GN015920.1	Q9TXQ1	26.2	2315	2422	2276	7.36e-123	438	TNKS1_CAEEL	Poly [ADP-ribose] polymerase tankyrase (EC 2.4.2.30) (Poly ADP-ribose metabolism enzyme 5) (Protein poly-ADP-ribosyltransferase tankyrase) (EC 2.4.2.-)	Caenorhabditis elegans	DNA damage response [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of programmed cell death [GO:0043069]; response to gamma radiation [GO:0010332]	NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]	chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003950; GO:0005634; GO:0005694; GO:0005730; GO:0006974; GO:0008630; GO:0010332; GO:0043069; GO:0140806; GO:0140807
GN015921	GN015921.1	Q8BG79	38.7	869	1031	887	3.22e-149	469	C19L2_MOUSE	Pre-mRNA splicing factor CWF19L2 (CWF19-like protein 2)	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; spliceosomal complex assembly [GO:0000245]		post-mRNA release spliceosomal complex [GO:0071014]; spliceosomal complex [GO:0005681]	GO:0000245; GO:0000398; GO:0005681; GO:0007283; GO:0007338; GO:0071014
GN015922	GN015922.1	P51871	41.8	400	396	537	7.64e-117	353	CP4F6_RAT	Cytochrome P450 4F6 (EC 1.14.14.1) (CYPIVF6)	Rattus norvegicus (Rat)	leukotriene metabolic process [GO:0006691]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005789; GO:0006691; GO:0016712; GO:0020037
GN015923	GN015923.1	P17635	45.8	504	544	535	7.36e-155	456	FMO2_RABIT	Dimethylaniline monooxygenase [N-oxide-forming] 2 (EC 1.14.13.-) (EC 1.14.13.8) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2)	Oryctolagus cuniculus (Rabbit)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0004499; GO:0005789; GO:0016020; GO:0050660; GO:0050661
GN015924	GN015924.1	P17635	42.0	528	576	535	5.03e-136	409	FMO2_RABIT	Dimethylaniline monooxygenase [N-oxide-forming] 2 (EC 1.14.13.-) (EC 1.14.13.8) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2)	Oryctolagus cuniculus (Rabbit)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0004499; GO:0005789; GO:0016020; GO:0050660; GO:0050661
GN015925	GN015925.1	P15208	40.7	81	214	1372	7.89e-09	58.5	INSR_MOUSE	Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]	Mus musculus (Mouse)	adrenal gland development [GO:0030325]; amyloid-beta clearance [GO:0097242]; animal organ morphogenesis [GO:0009887]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; dendritic spine maintenance [GO:0097062]; epidermis development [GO:0008544]; exocrine pancreas development [GO:0031017]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; heart morphogenesis [GO:0003007]; insulin receptor signaling pathway [GO:0008286]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; negative regulation of feeding behavior [GO:2000252]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transporter activity [GO:0032410]; neuron projection maintenance [GO:1990535]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of D-glucose import across plasma membrane [GO:0046326]; positive regulation of developmental growth [GO:0048639]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of glycolytic process [GO:0045821]; positive regulation of glycoprotein biosynthetic process [GO:0010560]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of meiotic cell cycle [GO:0051446]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of receptor internalization [GO:0002092]; positive regulation of respiratory burst [GO:0060267]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; receptor-mediated endocytosis [GO:0006898]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of female gonad development [GO:2000194]; regulation of hydrogen peroxide metabolic process [GO:0010310]; response to nutrient levels [GO:0031667]; response to tumor necrosis factor [GO:0034612]; symbiont entry into host cell [GO:0046718]	3-phosphoinositide-dependent protein kinase binding [GO:0043423]; amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; cargo receptor activity [GO:0038024]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; insulin receptor activity [GO:0005009]; insulin receptor substrate binding [GO:0043560]; insulin-like growth factor I binding [GO:0031994]; insulin-like growth factor II binding [GO:0031995]; insulin-like growth factor receptor binding [GO:0005159]; lipoic acid binding [GO:0031405]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein domain specific binding [GO:0019904]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; PTB domain binding [GO:0051425]; structural molecule activity [GO:0005198]	axon [GO:0030424]; caveola [GO:0005901]; cell body [GO:0044297]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; insulin receptor complex [GO:0005899]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; neuronal cell body membrane [GO:0032809]; nuclear envelope [GO:0005635]; nuclear lumen [GO:0031981]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; signaling receptor complex [GO:0043235]; yolk [GO:0060417]	GO:0001540; GO:0001933; GO:0002092; GO:0003007; GO:0004672; GO:0004713; GO:0005009; GO:0005159; GO:0005198; GO:0005524; GO:0005525; GO:0005635; GO:0005764; GO:0005768; GO:0005770; GO:0005886; GO:0005899; GO:0005901; GO:0006355; GO:0006468; GO:0006898; GO:0007186; GO:0008284; GO:0008286; GO:0008544; GO:0008584; GO:0009887; GO:0009897; GO:0010310; GO:0010560; GO:0010629; GO:0016020; GO:0018108; GO:0019901; GO:0019903; GO:0019904; GO:0030238; GO:0030295; GO:0030325; GO:0030335; GO:0030424; GO:0030425; GO:0031017; GO:0031405; GO:0031667; GO:0031981; GO:0031994; GO:0031995; GO:0032410; GO:0032590; GO:0032809; GO:0032869; GO:0034612; GO:0038024; GO:0038083; GO:0042327; GO:0042593; GO:0042802; GO:0043025; GO:0043123; GO:0043235; GO:0043243; GO:0043410; GO:0043423; GO:0043548; GO:0043559; GO:0043560; GO:0044297; GO:0044877; GO:0045429; GO:0045725; GO:0045821; GO:0045840; GO:0045893; GO:0045995; GO:0046326; GO:0046718; GO:0046777; GO:0048639; GO:0051425; GO:0051446; GO:0051897; GO:0055038; GO:0060267; GO:0060417; GO:0071363; GO:0097062; GO:0097242; GO:1990535; GO:2000194; GO:2000252
GN015929	GN015929.1	Q9VUX2	29.1	213	462	1226	4.07e-12	72.4	MIB_DROME	E3 ubiquitin-protein ligase mind-bomb (EC 2.3.2.27) (Mind bomb homolog) (D-mib) (Protein mind bob 1) (RING-type E3 ubiquitin transferase mind-bomb)	Drosophila melanogaster (Fruit fly)	endocytosis [GO:0006897]; intracellular protein localization [GO:0008104]; lateral inhibition [GO:0046331]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; positive regulation of Notch signaling pathway [GO:0045747]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]; sensory organ development [GO:0007423]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	apical cortex [GO:0045179]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0000209; GO:0004842; GO:0005737; GO:0005829; GO:0006897; GO:0007219; GO:0007423; GO:0008104; GO:0008270; GO:0008593; GO:0016567; GO:0045179; GO:0045747; GO:0045807; GO:0046331; GO:0061630
GN015931	GN015931.1	Q5ZIJ9	29.1	175	610	954	9.08e-09	62.4	MIB2_CHICK	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (RING-type E3 ubiquitin transferase MIB2)	Gallus gallus (Chicken)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN015932	GN015932.1	Q9BVR0	43.7	71	113	1158	4.83e-12	64.3	HRC23_HUMAN	Putative HERC2-like protein 3	Homo sapiens (Human)	protein ubiquitination [GO:0016567]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]	GO:0005737; GO:0016567; GO:0046872; GO:0061630
GN015933	GN015933.1	Q9VUX2	28.6	210	476	1226	4.41e-12	72.4	MIB_DROME	E3 ubiquitin-protein ligase mind-bomb (EC 2.3.2.27) (Mind bomb homolog) (D-mib) (Protein mind bob 1) (RING-type E3 ubiquitin transferase mind-bomb)	Drosophila melanogaster (Fruit fly)	endocytosis [GO:0006897]; intracellular protein localization [GO:0008104]; lateral inhibition [GO:0046331]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; positive regulation of Notch signaling pathway [GO:0045747]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]; sensory organ development [GO:0007423]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	apical cortex [GO:0045179]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0000209; GO:0004842; GO:0005737; GO:0005829; GO:0006897; GO:0007219; GO:0007423; GO:0008104; GO:0008270; GO:0008593; GO:0016567; GO:0045179; GO:0045747; GO:0045807; GO:0046331; GO:0061630
GN015934	GN015934.1	O60290	21.7	314	326	1169	6.76e-11	67.0	ZN862_HUMAN	Zinc finger protein 862	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	protein dimerization activity [GO:0046983]	nucleus [GO:0005634]	GO:0005634; GO:0006355; GO:0046983
GN015935	GN015935.1	O95714	45.3	75	608	4834	2.40e-12	74.3	HERC2_HUMAN	E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)	Homo sapiens (Human)	DNA damage response [GO:0006974]; intracellular protein transport [GO:0006886]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]	guanyl-nucleotide exchange factor activity [GO:0005085]; SUMO binding [GO:0032183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005085; GO:0005634; GO:0005654; GO:0005737; GO:0005814; GO:0005829; GO:0006886; GO:0006974; GO:0008270; GO:0016020; GO:0016567; GO:0031625; GO:0032183; GO:0043161; GO:0050821; GO:0061630
GN015936	GN015936.1	Q8AY68	40.0	340	485	465	1.32e-49	179	SHC1_XENLA	SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) (p60Shc)	Xenopus laevis (African clawed frog)	cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; intracellular signal transduction [GO:0035556]	receptor tyrosine kinase binding [GO:0030971]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0007169; GO:0030971; GO:0035556
GN015938	GN015938.1	F1RCY6	74.5	1108	1108	1100	0.0	1608	RENT1_DANRE	Regulator of nonsense transcripts 1 (EC 5.6.2.3) (EC 5.6.2.5) (ATP-dependent helicase RENT1) (Double-stranded nucleic acid 5'-3' helicase Upf1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	chordate embryonic development [GO:0043009]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000624]; regulation of gene expression [GO:0010468]; T cell differentiation in thymus [GO:0033077]	5'-3' DNA helicase activity [GO:0043139]; 5'-3' RNA helicase activity [GO:0032574]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]	GO:0000184; GO:0000932; GO:0000956; GO:0003677; GO:0003723; GO:0003724; GO:0005524; GO:0005634; GO:0005737; GO:0008270; GO:0010468; GO:0016787; GO:0032574; GO:0033077; GO:0043009; GO:0043139; GO:0048471; GO:2000624
GN015939	GN015939.1	O17087	47.2	267	475	1113	9.48e-64	226	GLD2_CAEEL	Poly(A) RNA polymerase gld-2 (EC 2.7.7.19) (Defective in germ line development protein 2)	Caenorhabditis elegans	cytosolic mRNA polyadenylation [GO:0180011]; embryo development ending in birth or egg hatching [GO:0009792]; mRNA 3'-end processing [GO:0031124]; mRNA processing [GO:0006397]; nucleus organization [GO:0006997]; positive regulation of meiosis I [GO:0060903]; positive regulation of mitotic nuclear division [GO:0045840]; regulation of cell division [GO:0051302]	poly(A) RNA polymerase activity [GO:1990817]	cytoplasm [GO:0005737]; P granule [GO:0043186]; protein-containing complex [GO:0032991]; RNA polymerase complex [GO:0030880]; RNA-directed RNA polymerase complex [GO:0031379]	GO:0005737; GO:0006397; GO:0006997; GO:0009792; GO:0030880; GO:0031124; GO:0031379; GO:0032991; GO:0043186; GO:0045840; GO:0051302; GO:0060903; GO:0180011; GO:1990817
GN015940	GN015940.1	P70399	35.0	551	1596	1969	3.32e-62	239	TP53B_MOUSE	TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)	Mus musculus (Mouse)	DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of isotype switching [GO:0045830]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; protein localization to site of double-strand break [GO:1990166]; regulation of DNA-templated transcription [GO:0006355]	damaged DNA binding [GO:0003684]; histone binding [GO:0042393]; histone H4K20me methyltransferase activity [GO:0140941]; histone H4K20me2 reader activity [GO:0140005]; histone reader activity [GO:0140566]; p53 binding [GO:0002039]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; telomeric repeat DNA binding [GO:0042162]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin-modified histone reader activity [GO:0061649]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; DNA repair complex [GO:1990391]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]	GO:0000077; GO:0000776; GO:0000781; GO:0002039; GO:0003684; GO:0003712; GO:0003713; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005737; GO:0006281; GO:0006303; GO:0006355; GO:0006974; GO:0016604; GO:0035861; GO:0042162; GO:0042393; GO:0043565; GO:0045830; GO:0045944; GO:0051260; GO:0061629; GO:0061649; GO:0097680; GO:0140005; GO:0140566; GO:0140941; GO:1902255; GO:1990166; GO:1990391; GO:2000042
GN015941	GN015941.1	Q9BMX5	81.7	235	241	247	1.93e-132	376	RS6_APLCA	Small ribosomal subunit protein eS6 (40S ribosomal protein S6)	Aplysia californica (California sea hare)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	ribosome [GO:0005840]	GO:0003735; GO:0005840; GO:0006412
GN015946	GN015946.1	Q9VCA2	28.0	543	560	548	2.25e-38	151	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN015947	GN015947.1	P80311	60.2	181	261	216	6.52e-74	227	PPIB_BOVIN	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	Bos taurus (Bovine)	bone development [GO:0060348]; host-mediated activation of viral genome replication [GO:0044829]; neutrophil chemotaxis [GO:0030593]; positive regulation of multicellular organism growth [GO:0040018]; protein folding [GO:0006457]; protein stabilization [GO:0050821]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA polymerase binding [GO:0070063]	endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	GO:0003755; GO:0005788; GO:0006457; GO:0016018; GO:0030593; GO:0032991; GO:0034663; GO:0040018; GO:0042470; GO:0044829; GO:0048471; GO:0050821; GO:0060348; GO:0070063
GN015948	GN015948.1	Q9BWL3	35.6	174	260	253	7.22e-17	80.9	LTAP1_HUMAN	Lipid transport auxiliary protein 1 (Hepatitis C virus NS5A-transactivated protein 4) (HCV NS5A-transactivated protein 4) (Protein NICE-3) (S863-3) (Spigot ortholog)	Homo sapiens (Human)	phagocytosis [GO:0006909]		endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0005739; GO:0005789; GO:0005794; GO:0005886; GO:0006909; GO:0140268
GN015949	GN015949.1	Q9Y2Y9	76.5	34	245	288	9.35e-11	63.9	KLF13_HUMAN	Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1)	Homo sapiens (Human)	negative regulation of cell population proliferation [GO:0008285]; negative regulation of erythrocyte differentiation [GO:0045647]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0006357; GO:0006366; GO:0008285; GO:0045647; GO:1990837
GN015950	GN015950.1	P86229	56.3	96	97	136	3.23e-31	109	KTAP2_CANLF	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 (Oligosaccharyl transferase subunit KCP2) (Keratinocyte-associated protein 2) (KCP-2)	Canis lupus familiaris (Dog) (Canis familiaris)	protein N-linked glycosylation [GO:0006487]	enzyme activator activity [GO:0008047]; protein-macromolecule adaptor activity [GO:0030674]	endoplasmic reticulum membrane [GO:0005789]; oligosaccharyltransferase complex A [GO:0160226]	GO:0005789; GO:0006487; GO:0008047; GO:0030674; GO:0160226
GN015951	GN015951.1	Q5R5L7	32.7	309	403	414	6.19e-39	147	ARRD3_PONAB	Arrestin domain-containing protein 3	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	protein transport [GO:0015031]		cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0015031
GN015953	GN015953.1	Q27218	29.5	322	391	507	2.50e-35	139	ACH7_CAEEL	Acetylcholine receptor subunit beta-type lev-1 (Levamisole-resistant protein 1)	Caenorhabditis elegans	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of egg-laying behavior [GO:0046662]; regulation of locomotion [GO:0040012]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]; transmembrane transport [GO:0055085]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0040012; GO:0042391; GO:0043005; GO:0043025; GO:0045202; GO:0045211; GO:0046662; GO:0055085
GN015957	GN015957.1	Q10981	33.0	206	255	343	1.49e-29	116	FUT2_HUMAN	Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; L-fucose catabolic process [GO:0042355]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation via fucose [GO:0036066]	alpha-(1,2)-fucosyltransferase activity [GO:0031127]; fucosyltransferase activity [GO:0008417]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005794; GO:0005975; GO:0006688; GO:0008107; GO:0008417; GO:0009101; GO:0009312; GO:0031127; GO:0032580; GO:0036066; GO:0042355; GO:0070062
GN015958	GN015958.1	O49326	29.0	328	317	471	2.47e-27	114	JAL21_ARATH	Thiohydroximate-O-sulfate sulfur/sulfate-lyase (nitrile-forming) NSP2 (EC 4.8.1.5) (Jacalin-related lectin 21) (Nitrile-specifier protein 2) (AtNSP2)	Arabidopsis thaliana (Mouse-ear cress)	embryo development ending in seed dormancy [GO:0009793]; glucosinolate catabolic process [GO:0019762]; nitrile biosynthetic process [GO:0080028]; seed dormancy process [GO:0010162]; seed germination [GO:0009845]	carbohydrate binding [GO:0030246]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]	GO:0005737; GO:0005783; GO:0009793; GO:0009845; GO:0010162; GO:0019762; GO:0030246; GO:0080028
GN015960	GN015960.1	P62248	39.1	69	71	174	8.75e-09	52.0	MYDGF_BOVIN	Myeloid-derived growth factor (MYDGF)	Bos taurus (Bovine)	negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]		endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]	GO:0001934; GO:0001938; GO:0005576; GO:0005783; GO:0005793; GO:0005794; GO:0043066; GO:0043410; GO:0045766; GO:0045944; GO:0051897
GN015961	GN015961.1	Q7ZWG6	29.6	382	515	481	1.24e-35	142	PCFT_DANRE	Proton-coupled folate transporter (Solute carrier family 46 member 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	transmembrane transport [GO:0055085]	methotrexate transmembrane transporter activity [GO:0015350]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]	GO:0005737; GO:0005768; GO:0005886; GO:0010008; GO:0015293; GO:0015350; GO:0016323; GO:0016324; GO:0022857; GO:0055085
GN015963	GN015963.1	B5X3B2	43.8	160	167	416	6.00e-49	166	APMAP_SALSA	Adipocyte plasma membrane-associated protein	Salmo salar (Atlantic salmon)		arylesterase activity [GO:0004064]	endomembrane system [GO:0012505]; membrane [GO:0016020]	GO:0004064; GO:0012505; GO:0016020
GN015964	GN015964.1	P11960	78.1	73	91	441	3.34e-32	119	ODBA_RAT	2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha)	Rattus norvegicus (Rat)	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA [GO:0120552]; branched-chain amino acid catabolic process [GO:0009083]; response to cAMP [GO:0051591]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584]	branched-chain 2-oxo acid dehydrogenase activity [GO:0003863]; protein-containing complex binding [GO:0044877]	branched-chain alpha-ketoacid dehydrogenase complex [GO:0160157]; mitochondrial matrix [GO:0005759]	GO:0003863; GO:0005759; GO:0007584; GO:0009083; GO:0044877; GO:0051384; GO:0051591; GO:0120552; GO:0160157
GN015965	GN015965.1	Q5PQ09	64.1	153	180	192	2.57e-76	229	DESI2_XENLA	Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing protein 1) (Palmitoyl protein thioesterase DESI2) (EC 3.1.2.22) (Protein FAM152A) (S-depalmitoylase DESI2)	Xenopus laevis (African clawed frog)	protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; palmitoyl-(protein) hydrolase activity [GO:0008474]	cytoplasm [GO:0005737]	GO:0004843; GO:0005737; GO:0008474; GO:0016579; GO:0052816; GO:0101005
GN015966	GN015966.1	Q09363	47.4	274	312	356	1.22e-78	246	SQV8_CAEEL	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8 (EC 2.4.1.135) (Glucuronyl transferase I) (GlcAT-I) (Squashed vulva protein 8) (Vulval invagination protein sqv-8)	Caenorhabditis elegans	chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; egg-laying behavior [GO:0018991]; embryo development ending in birth or egg hatching [GO:0009792]; morphogenesis of an epithelium [GO:0002009]; nematode pharynx development [GO:0160094]; spermatid development [GO:0007286]; vulval development [GO:0040025]	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018]; glucuronosyltransferase activity [GO:0015020]	Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0002009; GO:0007286; GO:0009792; GO:0015018; GO:0015020; GO:0016020; GO:0018991; GO:0040025; GO:0050650; GO:0160094
GN015967	GN015967.1	Q5M868	51.0	817	839	912	1.44e-299	850	GBA2_RAT	Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Bile acid beta-glucosidase GBA2) (Bile acid glucosyl transferase GBA2) (Cholesterol glucosyltransferase GBA2) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase GBA2) (EC 3.2.1.-) (Glucosylceramidase 2) (Non-lysosomal cholesterol glycosyltransferase) (Non-lysosomal galactosylceramidase) (EC 3.2.1.46) (Non-lysosomal glycosylceramidase)	Rattus norvegicus (Rat)	bile acid metabolic process [GO:0008206]; carbohydrate metabolic process [GO:0005975]; central nervous system development [GO:0007417]; central nervous system neuron development [GO:0021954]; cholesterol metabolic process [GO:0008203]; glucosylceramide catabolic process [GO:0006680]; glycolipid biosynthetic process [GO:0009247]; glycoside catabolic process [GO:0016139]; regulation of actin filament polymerization [GO:0030833]; regulation of membrane lipid distribution [GO:0097035]; regulation of microtubule polymerization [GO:0031113]	beta-glucosidase activity [GO:0008422]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glucosyltransferase activity [GO:0046527]; steryl-beta-glucosidase activity [GO:0050295]	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0004336; GO:0004348; GO:0005789; GO:0005829; GO:0005975; GO:0006680; GO:0007417; GO:0008203; GO:0008206; GO:0008422; GO:0009247; GO:0016020; GO:0016139; GO:0021954; GO:0030833; GO:0031113; GO:0046527; GO:0050295; GO:0097035
GN015968	GN015968.1	P59889	26.9	309	322	302	2.09e-20	92.8	S39A1_DANRE	Zinc transporter ZIP1 (DrZIP1) (Solute carrier family 39 member 1) (Zrt- and Irt-like protein 1) (ZIP-1)	Danio rerio (Zebrafish) (Brachydanio rerio)	zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	zinc ion binding [GO:0008270]; zinc ion transmembrane transporter activity [GO:0005385]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0005385; GO:0005789; GO:0005886; GO:0006829; GO:0008270; GO:0071577; GO:0071578
GN015969	GN015969.1	P59889	28.1	302	320	302	4.75e-26	108	S39A1_DANRE	Zinc transporter ZIP1 (DrZIP1) (Solute carrier family 39 member 1) (Zrt- and Irt-like protein 1) (ZIP-1)	Danio rerio (Zebrafish) (Brachydanio rerio)	zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	zinc ion binding [GO:0008270]; zinc ion transmembrane transporter activity [GO:0005385]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0005385; GO:0005789; GO:0005886; GO:0006829; GO:0008270; GO:0071577; GO:0071578
GN015971	GN015971.1	P59889	25.7	327	315	302	1.03e-21	96.3	S39A1_DANRE	Zinc transporter ZIP1 (DrZIP1) (Solute carrier family 39 member 1) (Zrt- and Irt-like protein 1) (ZIP-1)	Danio rerio (Zebrafish) (Brachydanio rerio)	zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	zinc ion binding [GO:0008270]; zinc ion transmembrane transporter activity [GO:0005385]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0005385; GO:0005789; GO:0005886; GO:0006829; GO:0008270; GO:0071577; GO:0071578
GN015975	GN015975.1	O94766	52.4	273	341	335	8.72e-90	275	B3GA3_HUMAN	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 3) (Glucuronosyltransferase I) (GlcAT-I) (UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) (GlcUAT-I)	Homo sapiens (Human)	chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; positive regulation of catalytic activity [GO:0043085]; positive regulation of intracellular protein transport [GO:0090316]	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity [GO:0015018]; glucuronosyltransferase activity [GO:0015020]; protein phosphatase activator activity [GO:0072542]	cis-Golgi network [GO:0005801]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0005794; GO:0005801; GO:0006024; GO:0015012; GO:0015018; GO:0015020; GO:0016020; GO:0043085; GO:0050650; GO:0050651; GO:0070062; GO:0072542; GO:0090316
GN015977	GN015977.1	P24367	62.2	74	81	207	4.62e-27	100	PPIB_CHICK	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	Gallus gallus (Chicken)	negative regulation of collagen fibril organization [GO:1904027]; protein folding [GO:0006457]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]; protein-containing complex [GO:0032991]	GO:0003755; GO:0005788; GO:0006457; GO:0016018; GO:0032991; GO:0042470; GO:1904027
GN015978	GN015978.1	Q9BWL3	35.6	174	260	253	7.22e-17	80.9	LTAP1_HUMAN	Lipid transport auxiliary protein 1 (Hepatitis C virus NS5A-transactivated protein 4) (HCV NS5A-transactivated protein 4) (Protein NICE-3) (S863-3) (Spigot ortholog)	Homo sapiens (Human)	phagocytosis [GO:0006909]		endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0005739; GO:0005789; GO:0005794; GO:0005886; GO:0006909; GO:0140268
GN015979	GN015979.1	Q9Y2Y9	76.5	34	245	288	9.35e-11	63.9	KLF13_HUMAN	Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1)	Homo sapiens (Human)	negative regulation of cell population proliferation [GO:0008285]; negative regulation of erythrocyte differentiation [GO:0045647]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0006357; GO:0006366; GO:0008285; GO:0045647; GO:1990837
GN015980	GN015980.1	Q5R5L7	32.7	309	403	414	6.19e-39	147	ARRD3_PONAB	Arrestin domain-containing protein 3	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	protein transport [GO:0015031]		cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0015031
GN015982	GN015982.1	Q27218	29.5	322	391	507	2.50e-35	139	ACH7_CAEEL	Acetylcholine receptor subunit beta-type lev-1 (Levamisole-resistant protein 1)	Caenorhabditis elegans	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of egg-laying behavior [GO:0046662]; regulation of locomotion [GO:0040012]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]; transmembrane transport [GO:0055085]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0040012; GO:0042391; GO:0043005; GO:0043025; GO:0045202; GO:0045211; GO:0046662; GO:0055085
GN015986	GN015986.1	Q10981	33.0	206	255	343	1.49e-29	116	FUT2_HUMAN	Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; L-fucose catabolic process [GO:0042355]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation via fucose [GO:0036066]	alpha-(1,2)-fucosyltransferase activity [GO:0031127]; fucosyltransferase activity [GO:0008417]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]	extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005794; GO:0005975; GO:0006688; GO:0008107; GO:0008417; GO:0009101; GO:0009312; GO:0031127; GO:0032580; GO:0036066; GO:0042355; GO:0070062
GN015987	GN015987.1	O49326	29.0	328	317	471	2.47e-27	114	JAL21_ARATH	Thiohydroximate-O-sulfate sulfur/sulfate-lyase (nitrile-forming) NSP2 (EC 4.8.1.5) (Jacalin-related lectin 21) (Nitrile-specifier protein 2) (AtNSP2)	Arabidopsis thaliana (Mouse-ear cress)	embryo development ending in seed dormancy [GO:0009793]; glucosinolate catabolic process [GO:0019762]; nitrile biosynthetic process [GO:0080028]; seed dormancy process [GO:0010162]; seed germination [GO:0009845]	carbohydrate binding [GO:0030246]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]	GO:0005737; GO:0005783; GO:0009793; GO:0009845; GO:0010162; GO:0019762; GO:0030246; GO:0080028
GN015989	GN015989.1	P97852	53.1	407	875	735	3.15e-129	408	DHB4_RAT	Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]	Rattus norvegicus (Rat)	androgen metabolic process [GO:0008209]; estrogen metabolic process [GO:0008210]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid biosynthetic process [GO:0006633]; medium-chain fatty-acyl-CoA metabolic process [GO:0036112]; response to steroid hormone [GO:0048545]; response to xenobiotic stimulus [GO:0009410]; Sertoli cell development [GO:0060009]; very long-chain fatty acid metabolic process [GO:0000038]; very long-chain fatty-acyl-CoA metabolic process [GO:0036111]	(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0106386]; (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0003857]; 17-beta-hydroxysteroid dehydrogenase (NAD+) activity [GO:0044594]; 3-hydroxyacyl-CoA dehydratase activity [GO:0018812]; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity [GO:0033989]; enoyl-CoA hydratase activity [GO:0004300]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity [GO:0102158]	peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0000038; GO:0003857; GO:0004300; GO:0004303; GO:0005777; GO:0005782; GO:0006633; GO:0006635; GO:0008209; GO:0008210; GO:0009410; GO:0018812; GO:0033540; GO:0033989; GO:0036111; GO:0036112; GO:0042802; GO:0042803; GO:0044594; GO:0048545; GO:0060009; GO:0102158; GO:0106386
GN015990	GN015990.1	Q29RU9	50.4	387	380	392	7.81e-128	375	SOX_BOVIN	Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase)	Bos taurus (Bovine)	L-lysine catabolic process [GO:0019477]	flavin adenine dinucleotide binding [GO:0050660]; L-pipecolate oxidase activity [GO:0050031]; sarcosine oxidase activity [GO:0008115]	peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0005777; GO:0005782; GO:0008115; GO:0019477; GO:0050031; GO:0050660
GN015992	GN015992.1	B7ZFT1	39.0	100	106	101	1.08e-17	74.7	GLRX1_RHIID	Glutaredoxin-1 (Glutathione-dependent oxidoreductase 1)	Rhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194) (Arbuscular mycorrhizal fungus) (Glomus intraradices)	cellular response to oxidative stress [GO:0034599]	glutathione disulfide oxidoreductase activity [GO:0015038]; glutathione peroxidase activity [GO:0004602]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004602; GO:0005634; GO:0005829; GO:0015038; GO:0034599
GN015994	GN015994.1	Q9BMX5	75.4	69	86	247	5.79e-21	85.9	RS6_APLCA	Small ribosomal subunit protein eS6 (40S ribosomal protein S6)	Aplysia californica (California sea hare)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	ribosome [GO:0005840]	GO:0003735; GO:0005840; GO:0006412
GN015995	GN015995.1	P70399	35.0	551	1596	1969	3.32e-62	239	TP53B_MOUSE	TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)	Mus musculus (Mouse)	DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of isotype switching [GO:0045830]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; protein localization to site of double-strand break [GO:1990166]; regulation of DNA-templated transcription [GO:0006355]	damaged DNA binding [GO:0003684]; histone binding [GO:0042393]; histone H4K20me methyltransferase activity [GO:0140941]; histone H4K20me2 reader activity [GO:0140005]; histone reader activity [GO:0140566]; p53 binding [GO:0002039]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific DNA binding [GO:0043565]; telomeric repeat DNA binding [GO:0042162]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; ubiquitin-modified histone reader activity [GO:0061649]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; DNA repair complex [GO:1990391]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]	GO:0000077; GO:0000776; GO:0000781; GO:0002039; GO:0003684; GO:0003712; GO:0003713; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005737; GO:0006281; GO:0006303; GO:0006355; GO:0006974; GO:0016604; GO:0035861; GO:0042162; GO:0042393; GO:0043565; GO:0045830; GO:0045944; GO:0051260; GO:0061629; GO:0061649; GO:0097680; GO:0140005; GO:0140566; GO:0140941; GO:1902255; GO:1990166; GO:1990391; GO:2000042
GN015996	GN015996.1	O17087	47.2	267	669	1113	8.32e-62	226	GLD2_CAEEL	Poly(A) RNA polymerase gld-2 (EC 2.7.7.19) (Defective in germ line development protein 2)	Caenorhabditis elegans	cytosolic mRNA polyadenylation [GO:0180011]; embryo development ending in birth or egg hatching [GO:0009792]; mRNA 3'-end processing [GO:0031124]; mRNA processing [GO:0006397]; nucleus organization [GO:0006997]; positive regulation of meiosis I [GO:0060903]; positive regulation of mitotic nuclear division [GO:0045840]; regulation of cell division [GO:0051302]	poly(A) RNA polymerase activity [GO:1990817]	cytoplasm [GO:0005737]; P granule [GO:0043186]; protein-containing complex [GO:0032991]; RNA polymerase complex [GO:0030880]; RNA-directed RNA polymerase complex [GO:0031379]	GO:0005737; GO:0006397; GO:0006997; GO:0009792; GO:0030880; GO:0031124; GO:0031379; GO:0032991; GO:0043186; GO:0045840; GO:0051302; GO:0060903; GO:0180011; GO:1990817
GN015997	GN015997.1	Q8AY68	55.0	40	69	465	1.57e-09	55.1	SHC1_XENLA	SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) (p60Shc)	Xenopus laevis (African clawed frog)	cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; intracellular signal transduction [GO:0035556]	receptor tyrosine kinase binding [GO:0030971]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0007169; GO:0030971; GO:0035556
GN015998	GN015998.1	Q8AY68	40.0	360	375	465	1.41e-55	192	SHC1_XENLA	SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) (p60Shc)	Xenopus laevis (African clawed frog)	cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; intracellular signal transduction [GO:0035556]	receptor tyrosine kinase binding [GO:0030971]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0007169; GO:0030971; GO:0035556
GN016000	GN016000.1	Q8R1J3	34.0	159	242	271	9.30e-10	60.8	ZCHC9_MOUSE	Zinc finger CCHC domain-containing protein 9	Mus musculus (Mouse)		nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003676; GO:0005634; GO:0005654; GO:0005730; GO:0008270
GN016001	GN016001.1	O95714	45.3	75	608	4834	2.40e-12	74.3	HERC2_HUMAN	E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)	Homo sapiens (Human)	DNA damage response [GO:0006974]; intracellular protein transport [GO:0006886]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]	guanyl-nucleotide exchange factor activity [GO:0005085]; SUMO binding [GO:0032183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005085; GO:0005634; GO:0005654; GO:0005737; GO:0005814; GO:0005829; GO:0006886; GO:0006974; GO:0008270; GO:0016020; GO:0016567; GO:0031625; GO:0032183; GO:0043161; GO:0050821; GO:0061630
GN016004	GN016004.1	Q5ZIJ9	29.1	175	584	954	8.43e-09	62.4	MIB2_CHICK	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (RING-type E3 ubiquitin transferase MIB2)	Gallus gallus (Chicken)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN016005	GN016005.1	P34456	26.2	172	172	419	2.43e-13	70.1	YMD2_CAEEL	Uncharacterized protein F54H12.2	Caenorhabditis elegans	deoxyribonucleotide biosynthetic process [GO:0009263]	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]	cytosol [GO:0005829]	GO:0004748; GO:0005829; GO:0009263
GN016007	GN016007.1	Q4U2R1	42.0	81	111	4836	9.24e-10	57.8	HERC2_MOUSE	E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; negative regulation of Notch signaling pathway [GO:0045746]; neuron differentiation [GO:0030182]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]	SUMO binding [GO:0032183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005737; GO:0005743; GO:0005814; GO:0005829; GO:0005886; GO:0006974; GO:0007283; GO:0008270; GO:0016567; GO:0030182; GO:0031625; GO:0032183; GO:0043161; GO:0045746; GO:0050821; GO:0061630
GN016013	GN016013.1	Q6R7G0	20.7	518	623	693	1.30e-10	68.2	Y068_OSHVF	Putative transmembrane protein ORF68	Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)			host cell membrane [GO:0033644]	GO:0033644
GN016018	GN016018.1	Q6R7G0	20.7	518	623	693	1.30e-10	68.2	Y068_OSHVF	Putative transmembrane protein ORF68	Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)			host cell membrane [GO:0033644]	GO:0033644
GN016019	GN016019.1	A0A2B4RNI3	33.3	162	561	688	8.63e-22	103	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN016022	GN016022.1	Q9Y6V7	61.8	437	461	483	1.73e-187	534	DDX49_HUMAN	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.4.13) (DEAD box protein 49)	Homo sapiens (Human)	positive regulation of cell growth [GO:0030307]; regulation of rRNA stability [GO:0044357]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0003723; GO:0003724; GO:0005524; GO:0005654; GO:0005730; GO:0016887; GO:0030307; GO:0044357
GN016023	GN016023.1	Q5U2U0	43.8	527	575	633	1.09e-120	373	CLPX_RAT	ATP-dependent clpX-like chaperone, mitochondrial (EC 3.6.4.10) (ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial) (Caseinolytic mitochondrial matrix peptidase chaperone subunit X)	Rattus norvegicus (Rat)	ATP metabolic process [GO:0046034]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; peptidase activator activity [GO:0016504]	endopeptidase Clp complex [GO:0009368]; mitochondrial endopeptidase Clp complex [GO:0009841]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	GO:0005524; GO:0005739; GO:0005759; GO:0006508; GO:0009368; GO:0009841; GO:0016504; GO:0016887; GO:0030163; GO:0042645; GO:0046034; GO:0140662
GN016026	GN016026.1	Q708S7	23.9	447	726	501	1.53e-13	77.4	ASI1A_DANRE	Acid-sensing ion channel 1A (ASIC1-A) (Acid-sensing ion channel 1.2-A) (Amiloride-sensitive cation channel 2-B, neuronal-A) (ZASIC1.2)	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to pH [GO:0071467]; sodium ion transmembrane transport [GO:0035725]	ligand-gated sodium channel activity [GO:0015280]; monoatomic cation channel activity [GO:0005261]; pH-gated monoatomic ion channel activity [GO:0160128]	dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0005261; GO:0005886; GO:0015280; GO:0030425; GO:0035725; GO:0045211; GO:0071467; GO:0098978; GO:0160128
GN016027	GN016027.1	Q2XWK0	44.8	420	416	548	1.17e-121	367	SVOP_XENLA	Synaptic vesicle 2-related protein (SV2-related protein)	Xenopus laevis (African clawed frog)		transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; synaptic vesicle membrane [GO:0030672]	GO:0016020; GO:0022857; GO:0030672
GN016028	GN016028.1	Q86WQ0	44.8	87	106	139	1.14e-24	93.6	NR2CA_HUMAN	Nuclear receptor 2C2-associated protein (TR4 orphan receptor-associated 16 kDa protein)	Homo sapiens (Human)			nucleoplasm [GO:0005654]	GO:0005654
GN016029	GN016029.1	P59889	28.6	339	350	302	3.01e-34	130	S39A1_DANRE	Zinc transporter ZIP1 (DrZIP1) (Solute carrier family 39 member 1) (Zrt- and Irt-like protein 1) (ZIP-1)	Danio rerio (Zebrafish) (Brachydanio rerio)	zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	zinc ion binding [GO:0008270]; zinc ion transmembrane transporter activity [GO:0005385]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0005385; GO:0005789; GO:0005886; GO:0006829; GO:0008270; GO:0071577; GO:0071578
GN016030	GN016030.1	Q22795	38.7	142	944	242	1.00e-22	101	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN016033	GN016033.1	Q6R7G0	19.9	468	580	693	2.34e-12	73.6	Y068_OSHVF	Putative transmembrane protein ORF68	Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)			host cell membrane [GO:0033644]	GO:0033644
GN016034	GN016034.1	Q6R7G0	21.1	393	602	693	1.61e-10	67.8	Y068_OSHVF	Putative transmembrane protein ORF68	Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)			host cell membrane [GO:0033644]	GO:0033644
GN016036	GN016036.1	Q8R2Y3	33.2	410	468	534	2.96e-44	166	DOLK_MOUSE	Dolichol kinase (EC 2.7.1.108) (Transmembrane protein 15)	Mus musculus (Mouse)	dolichol phosphate mannose biosynthetic process [GO:0180047]; dolichyl monophosphate biosynthetic process [GO:0043048]; protein N-linked glycosylation [GO:0006487]	dolichol kinase activity [GO:0004168]	endoplasmic reticulum membrane [GO:0005789]; nucleolus [GO:0005730]	GO:0004168; GO:0005730; GO:0005789; GO:0006487; GO:0043048; GO:0180047
GN016037	GN016037.1	Q63639	66.6	344	344	518	1.77e-164	472	AL1A2_RAT	Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (ALDH1A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II))	Rattus norvegicus (Rat)	9-cis-retinoic acid biosynthetic process [GO:0042904]; aldehyde metabolic process [GO:0006081]; anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; camera-type eye development [GO:0043010]; cardiac muscle tissue development [GO:0048738]; cellular response to retinoic acid [GO:0071300]; determination of bilateral symmetry [GO:0009855]; embryonic camera-type eye development [GO:0031076]; embryonic digestive tract development [GO:0048566]; embryonic forelimb morphogenesis [GO:0035115]; embryonic limb morphogenesis [GO:0030326]; face development [GO:0060324]; forebrain development [GO:0030900]; heart morphogenesis [GO:0003007]; hindbrain development [GO:0030902]; kidney development [GO:0001822]; liver development [GO:0001889]; lung development [GO:0030324]; midgut development [GO:0007494]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of cell population proliferation [GO:0008285]; neural crest cell development [GO:0014032]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; pituitary gland development [GO:0021983]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; protein homotetramerization [GO:0051289]; proximal/distal pattern formation [GO:0009954]; regulation of endothelial cell proliferation [GO:0001936]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoic acid metabolic process [GO:0042573]; retinoic acid receptor signaling pathway [GO:0048384]; retinol metabolic process [GO:0042572]; ureter maturation [GO:0035799]	3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; retinal binding [GO:0016918]; retinal dehydrogenase (NAD+) activity [GO:0001758]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]	GO:0001568; GO:0001758; GO:0001822; GO:0001889; GO:0001936; GO:0002138; GO:0003007; GO:0004028; GO:0004029; GO:0005737; GO:0006081; GO:0007494; GO:0008284; GO:0008285; GO:0009855; GO:0009952; GO:0009954; GO:0010628; GO:0014032; GO:0016331; GO:0016918; GO:0021915; GO:0021983; GO:0030182; GO:0030324; GO:0030326; GO:0030900; GO:0030902; GO:0031016; GO:0031076; GO:0032355; GO:0032526; GO:0033189; GO:0034097; GO:0035115; GO:0035799; GO:0042572; GO:0042573; GO:0042574; GO:0042904; GO:0043010; GO:0043065; GO:0048384; GO:0048471; GO:0048566; GO:0048738; GO:0051289; GO:0060324; GO:0071300
GN016038	GN016038.1	Q62148	61.0	382	394	518	5.16e-160	462	AL1A2_MOUSE	Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (ALDH1A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II))	Mus musculus (Mouse)	9-cis-retinoic acid biosynthetic process [GO:0042904]; aldehyde metabolic process [GO:0006081]; anterior/posterior pattern specification [GO:0009952]; blood vessel development [GO:0001568]; camera-type eye development [GO:0043010]; cardiac muscle tissue development [GO:0048738]; cellular response to retinoic acid [GO:0071300]; determination of bilateral symmetry [GO:0009855]; embryonic camera-type eye development [GO:0031076]; embryonic digestive tract development [GO:0048566]; embryonic forelimb morphogenesis [GO:0035115]; embryonic limb morphogenesis [GO:0030326]; face development [GO:0060324]; forebrain development [GO:0030900]; heart development [GO:0007507]; heart looping [GO:0001947]; heart morphogenesis [GO:0003007]; hindbrain development [GO:0030902]; kidney development [GO:0001822]; liver development [GO:0001889]; lung development [GO:0030324]; midgut development [GO:0007494]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of cell population proliferation [GO:0008285]; neural crest cell development [GO:0014032]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; pituitary gland development [GO:0021983]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; protein homotetramerization [GO:0051289]; proximal/distal pattern formation [GO:0009954]; regulation of endothelial cell proliferation [GO:0001936]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoic acid metabolic process [GO:0042573]; retinoic acid receptor signaling pathway [GO:0048384]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; ureter maturation [GO:0035799]	3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; retinal binding [GO:0016918]; retinal dehydrogenase (NAD+) activity [GO:0001758]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]	GO:0001523; GO:0001568; GO:0001758; GO:0001822; GO:0001889; GO:0001936; GO:0001947; GO:0002138; GO:0003007; GO:0004028; GO:0004029; GO:0005737; GO:0006081; GO:0007494; GO:0007507; GO:0008284; GO:0008285; GO:0009855; GO:0009952; GO:0009954; GO:0010628; GO:0014032; GO:0016331; GO:0016918; GO:0021915; GO:0021983; GO:0030182; GO:0030324; GO:0030326; GO:0030900; GO:0030902; GO:0031016; GO:0031076; GO:0032355; GO:0032526; GO:0033189; GO:0034097; GO:0035115; GO:0035799; GO:0042572; GO:0042573; GO:0042574; GO:0042904; GO:0043010; GO:0043065; GO:0048384; GO:0048471; GO:0048566; GO:0048738; GO:0051289; GO:0060324; GO:0071300
GN016052	GN016052.1	Q21263	61.8	123	566	351	2.37e-43	161	PAX2H_CAEEL	Paired box protein 2 homolog (Paired box transcription factor 2)	Caenorhabditis elegans	apoptotic process [GO:0006915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0005634; GO:0005694; GO:0006357; GO:0006915; GO:0045944
GN016053	GN016053.1	Q0VCP2	33.2	241	247	247	1.47e-32	122	PX11A_BOVIN	Peroxisomal membrane protein 11A (Peroxin-11A) (Peroxisomal biogenesis factor 11A)	Bos taurus (Bovine)	peroxisome fission [GO:0016559]		peroxisomal membrane [GO:0005778]	GO:0005778; GO:0016559
GN016054	GN016054.1	P29372	46.3	121	123	298	3.49e-27	104	3MG_HUMAN	DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase)	Homo sapiens (Human)	base-excision repair [GO:0006284]; depurination [GO:0045007]; DNA alkylation repair [GO:0006307]	alkylbase DNA N-glycosylase activity [GO:0003905]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]	cytosol [GO:0005829]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0003677; GO:0003684; GO:0003905; GO:0005654; GO:0005739; GO:0005829; GO:0006284; GO:0006307; GO:0019104; GO:0042645; GO:0045007
GN016056	GN016056.1	O49447	68.8	298	304	379	1.81e-135	391	ADT3_ARATH	ADP/ATP translocase 3, mitochondrial (ADP,ATP carrier protein 3) (Adenine nucleotide translocator 3) (ANT 3)	Arabidopsis thaliana (Mouse-ear cress)	mitochondrial ADP transmembrane transport [GO:0140021]; mitochondrial ATP transmembrane transport [GO:1990544]; purine nucleotide transport [GO:0015865]; regulation of mitochondrial membrane permeability [GO:0046902]	ATP:ADP antiporter activity [GO:0005471]	chloroplast envelope [GO:0009941]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0005471; GO:0005739; GO:0005743; GO:0005757; GO:0005886; GO:0009941; GO:0015865; GO:0016020; GO:0046902; GO:0140021; GO:1990544
GN016058	GN016058.1	O96011	29.7	202	200	259	1.70e-24	99.8	PX11B_HUMAN	Peroxisomal membrane protein 11B (Peroxin-11B) (Peroxisomal biogenesis factor 11B) (Protein PEX11 homolog beta) (PEX11-beta)	Homo sapiens (Human)	peroxisome fission [GO:0016559]; peroxisome organization [GO:0007031]; regulation of peroxisome size [GO:0044375]; signal transduction [GO:0007165]	identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]	GO:0005739; GO:0005777; GO:0005778; GO:0005829; GO:0007031; GO:0007165; GO:0016020; GO:0016559; GO:0032991; GO:0042802; GO:0042803; GO:0044375
GN016059	GN016059.1	P23377	52.6	568	945	793	1.33e-187	563	FURIN_RAT	Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) (Prohormone convertase 3)	Rattus norvegicus (Rat)	blastocyst formation [GO:0001825]; cholesterol homeostasis [GO:0042632]; cytokine precursor processing [GO:0140447]; dibasic protein processing [GO:0090472]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor production [GO:0032902]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; positive regulation of cell migration [GO:0030335]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein maturation [GO:0051604]; protein processing [GO:0016485]; regulation of cholesterol transport [GO:0032374]; regulation of protein catabolic process [GO:0042176]; regulation of signal transduction [GO:0009966]; secretion by cell [GO:0032940]; viral life cycle [GO:0019058]; zymogen activation [GO:0031638]; zymogen inhibition [GO:0097341]	endopeptidase activator activity [GO:0061133]; endopeptidase activity [GO:0004175]; endopeptidase inhibitor activity [GO:0004866]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; nerve growth factor binding [GO:0048406]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; protease binding [GO:0002020]; serine-type endopeptidase activity [GO:0004252]; serine-type endopeptidase inhibitor activity [GO:0004867]; serine-type peptidase activity [GO:0008236]; signal peptidase activity [GO:0009003]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]	GO:0000139; GO:0001825; GO:0002020; GO:0004175; GO:0004252; GO:0004866; GO:0004867; GO:0005576; GO:0005783; GO:0005789; GO:0005794; GO:0005796; GO:0005802; GO:0005886; GO:0008201; GO:0008233; GO:0008236; GO:0009003; GO:0009966; GO:0009986; GO:0010008; GO:0016485; GO:0016486; GO:0019058; GO:0030140; GO:0030335; GO:0030511; GO:0031638; GO:0031985; GO:0032374; GO:0032804; GO:0032902; GO:0032911; GO:0032940; GO:0042176; GO:0042277; GO:0042632; GO:0043043; GO:0045121; GO:0048406; GO:0051604; GO:0061133; GO:0090472; GO:0097341; GO:0140447; GO:1904399
GN016060	GN016060.1	Q9P0K7	45.9	74	336	980	1.29e-10	66.2	RAI14_HUMAN	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)	Homo sapiens (Human)		actin binding [GO:0003779]	anchoring junction [GO:0070161]; cell cortex [GO:0005938]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; stress fiber [GO:0001725]	GO:0001725; GO:0003779; GO:0005634; GO:0005654; GO:0005829; GO:0005938; GO:0070161
GN016061	GN016061.1	Q9GL21	52.4	84	608	1415	1.06e-11	72.0	UACA_CANLF	Uveal autoantigen with coiled-coil domains and ankyrin repeats	Canis lupus familiaris (Dog) (Canis familiaris)	intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of inflammatory response [GO:0050728]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]	actin binding [GO:0003779]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003779; GO:0005634; GO:0005829; GO:0005856; GO:0008630; GO:0008631; GO:0050728; GO:1901223
GN016064	GN016064.1	Q5ZLS2	39.5	549	533	506	3.24e-111	343	EDC3_CHICK	Enhancer of mRNA-decapping protein 3 (YjeF domain-containing protein 1)	Gallus gallus (Chicken)	deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; P-body assembly [GO:0033962]	mRNA binding [GO:0003729]	P-body [GO:0000932]	GO:0000932; GO:0003729; GO:0031087; GO:0033962
GN016066	GN016066.1	Q8VHR5	47.7	262	699	594	2.82e-46	177	P66B_MOUSE	Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)	Mus musculus (Mouse)	chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of cell fate specification [GO:0042659]; regulation of stem cell differentiation [GO:2000736]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]	GO:0000122; GO:0000781; GO:0000981; GO:0005634; GO:0005654; GO:0005694; GO:0006338; GO:0008270; GO:0016581; GO:0016607; GO:0042659; GO:0043565; GO:0045892; GO:0045893; GO:2000736
GN016067	GN016067.1	Q96PU5	72.3	329	348	975	1.56e-170	503	NED4L_HUMAN	E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)	Homo sapiens (Human)	monoatomic ion transmembrane transport [GO:0034220]; negative regulation of potassium ion export across plasma membrane [GO:1903765]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sodium ion import across plasma membrane [GO:1903783]; negative regulation of sodium ion transmembrane transport [GO:1902306]; neuromuscular junction development [GO:0007528]; neuron projection development [GO:0031175]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of dendrite extension [GO:1903861]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; receptor catabolic process [GO:0032801]; receptor internalization [GO:0031623]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of membrane repolarization [GO:0060306]; regulation of protein stability [GO:0031647]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of synapse organization [GO:0050807]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular cardiac muscle cell action potential [GO:0086005]	potassium channel inhibitor activity [GO:0019870]; sodium channel inhibitor activity [GO:0019871]; sodium channel regulator activity [GO:0017080]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]	GO:0003254; GO:0004842; GO:0005654; GO:0005737; GO:0005771; GO:0005794; GO:0005829; GO:0006511; GO:0006513; GO:0007528; GO:0016324; GO:0016567; GO:0017080; GO:0019870; GO:0019871; GO:0031175; GO:0031623; GO:0031647; GO:0032801; GO:0034220; GO:0042391; GO:0043161; GO:0044325; GO:0045732; GO:0048814; GO:0050807; GO:0060306; GO:0061630; GO:0070062; GO:0070936; GO:0086005; GO:1901380; GO:1902305; GO:1902306; GO:1903765; GO:1903783; GO:1903861; GO:2000009; GO:2001288
GN016069	GN016069.1	B4ZIX8	58.6	461	468	607	2.67e-186	536	SCC4_XENLA	MAU2 chromatid cohesion factor homolog (MAU-2) (Cohesin loading complex subunit SCC4 homolog)	Xenopus laevis (African clawed frog)	maintenance of mitotic sister chromatid cohesion [GO:0034088]; mitotic sister chromatid cohesion [GO:0007064]		chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Scc2-Scc4 cohesin loading complex [GO:0090694]; SMC loading complex [GO:0032116]	GO:0000785; GO:0005634; GO:0005654; GO:0007064; GO:0032116; GO:0034088; GO:0090694
GN016070	GN016070.1	Q9JLC8	25.3	4585	4204	4582	2.60e-316	1066	SACS_MOUSE	Sacsin (DnaJ homolog subfamily C member 29)	Mus musculus (Mouse)	negative regulation of inclusion body assembly [GO:0090084]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0090084
GN016071	GN016071.1	Q9JLC8	24.8	4579	4166	4582	4.86e-297	1007	SACS_MOUSE	Sacsin (DnaJ homolog subfamily C member 29)	Mus musculus (Mouse)	negative regulation of inclusion body assembly [GO:0090084]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0090084
GN016072	GN016072.1	Q8TER0	37.2	282	582	1413	5.49e-49	187	SNED1_HUMAN	Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)	Homo sapiens (Human)	cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]	calcium ion binding [GO:0005509]; Notch binding [GO:0005112]	extracellular matrix [GO:0031012]	GO:0005112; GO:0005509; GO:0007160; GO:0031012; GO:0033627
GN016073	GN016073.1	Q92178	39.7	413	412	700	3.91e-98	310	CAN2_CHICK	Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)	Gallus gallus (Chicken)	cellular response to amino acid stimulus [GO:0071230]; proteolysis [GO:0006508]	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; protein tyrosine kinase binding [GO:1990782]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; plasma membrane [GO:0005886]	GO:0004198; GO:0005509; GO:0005737; GO:0005886; GO:0006508; GO:0030425; GO:0071230; GO:1990782
GN016074	GN016074.1	A6QP74	29.9	355	543	462	6.40e-38	148	CALRL_BOVIN	Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor)	Bos taurus (Bovine)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; receptor internalization [GO:0031623]	adrenomedullin receptor activity [GO:0001605]; calcitonin gene-related peptide receptor activity [GO:0001635]; calcitonin receptor activity [GO:0004948]	plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001525; GO:0001605; GO:0001635; GO:0004948; GO:0005886; GO:0007166; GO:0007189; GO:0031623; GO:0043235
GN016076	GN016076.1	G5EBI4	38.9	131	134	404	9.59e-20	86.7	CEEH1_CAEEL	Epoxide hydrolase 1 (EC 3.3.2.10) (CEEH1)	Caenorhabditis elegans	lipid metabolic process [GO:0006629]	epoxide hydrolase activity [GO:0004301]	membrane [GO:0016020]	GO:0004301; GO:0006629; GO:0016020
GN016079	GN016079.1	P11230	29.0	176	196	501	7.28e-10	60.8	ACHB_HUMAN	Acetylcholine receptor subunit beta	Homo sapiens (Human)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; muscle cell development [GO:0055001]; muscle contraction [GO:0006936]; nervous system process [GO:0050877]; neuromuscular synaptic transmission [GO:0007274]; postsynaptic membrane organization [GO:0001941]; regulation of membrane potential [GO:0042391]; signal transduction [GO:0007165]; skeletal muscle contraction [GO:0003009]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]; ligand-gated monoatomic ion channel activity [GO:0015276]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	acetylcholine-gated channel complex [GO:0005892]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]	GO:0001941; GO:0003009; GO:0004888; GO:0005886; GO:0005892; GO:0006812; GO:0006816; GO:0006936; GO:0007165; GO:0007271; GO:0007274; GO:0015267; GO:0015276; GO:0022848; GO:0030594; GO:0031594; GO:0034220; GO:0035095; GO:0042166; GO:0042391; GO:0043005; GO:0045202; GO:0050877; GO:0051899; GO:0055001; GO:0095500; GO:0099634; GO:1904315
GN016082	GN016082.1	P71359	27.6	134	120	619	7.01e-11	61.2	RECQ_HAEIN	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]	GO:0003676; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0009432; GO:0016887; GO:0030894; GO:0043138; GO:0043590
GN016089	GN016089.1	O43301	27.8	371	325	675	1.22e-31	128	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN016090	GN016090.1	Q16222	53.1	516	498	522	3.46e-179	516	UAP1_HUMAN	UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; positive regulation of type I interferon production [GO:0032481]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	identical protein binding [GO:0042802]; protein serine pyrophosphorylase activity [GO:0141090]; UDP-N-acetylgalactosamine diphosphorylase activity [GO:0052630]; UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977]	cytosol [GO:0005829]	GO:0003977; GO:0005829; GO:0006048; GO:0032481; GO:0042802; GO:0052630; GO:0140374; GO:0141090
GN016091	GN016091.1	A0A1D5NSM8	24.4	505	900	3615	1.06e-13	79.7	SVEP1_DANRE	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)	Danio rerio (Zebrafish) (Brachydanio rerio)	cell migration [GO:0016477]; epidermal cell differentiation [GO:0009913]; epidermis development [GO:0008544]; epithelial cell-cell adhesion [GO:0090136]; lymph vessel development [GO:0001945]; lymph vessel morphogenesis [GO:0036303]	calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0001945; GO:0005509; GO:0005576; GO:0005634; GO:0005737; GO:0008544; GO:0009913; GO:0016020; GO:0016477; GO:0036303; GO:0090136
GN016094	GN016094.1	O43301	29.1	206	205	675	2.75e-15	77.0	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN016095	GN016095.1	Q16222	55.8	516	508	522	1.87e-196	560	UAP1_HUMAN	UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; positive regulation of type I interferon production [GO:0032481]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	identical protein binding [GO:0042802]; protein serine pyrophosphorylase activity [GO:0141090]; UDP-N-acetylgalactosamine diphosphorylase activity [GO:0052630]; UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977]	cytosol [GO:0005829]	GO:0003977; GO:0005829; GO:0006048; GO:0032481; GO:0042802; GO:0052630; GO:0140374; GO:0141090
GN016096	GN016096.1	Q14746	45.9	736	760	738	1.61e-206	603	COG2_HUMAN	Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein)	Homo sapiens (Human)	Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	protein-containing complex binding [GO:0044877]	COG complex [GO:0017119]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; trans-Golgi network membrane [GO:0032588]	GO:0000139; GO:0000301; GO:0005795; GO:0006891; GO:0007030; GO:0015031; GO:0017119; GO:0032588; GO:0044877
GN016100	GN016100.1	Q01459	41.0	300	297	385	1.92e-71	228	DIAC_HUMAN	Di-N-acetylchitobiase (EC 3.2.1.-)	Homo sapiens (Human)	carbohydrate catabolic process [GO:0016052]; chitin catabolic process [GO:0006032]; oligosaccharide catabolic process [GO:0009313]	chitin binding [GO:0008061]; chitinase activity [GO:0004568]; hydrolase activity, acting on glycosyl bonds [GO:0016798]	extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0004568; GO:0005576; GO:0005764; GO:0006032; GO:0008061; GO:0009313; GO:0016052; GO:0016798
GN016104	GN016104.1	Q9VBW0	50.6	83	149	177	5.98e-22	89.4	SAYS1_DROME	SAYSvFN domain-containing protein 1	Drosophila melanogaster (Fruit fly)	protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; rescue of stalled cytosolic ribosome [GO:0072344]	UFM1-modified protein reader activity [GO:0141185]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0006515; GO:0072344; GO:0141185
GN016105	GN016105.1	Q8WZA2	79.3	198	213	1011	8.78e-97	305	RPGF4_HUMAN	Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII)	Homo sapiens (Human)	adaptive immune response [GO:0002250]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of insulin secretion [GO:0032024]; Rap protein signal transduction [GO:0032486]; regulation of synaptic vesicle cycle [GO:0098693]	cAMP binding [GO:0030552]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0002250; GO:0005085; GO:0005829; GO:0005886; GO:0007186; GO:0016020; GO:0030552; GO:0030674; GO:0031267; GO:0032024; GO:0032486; GO:0098686; GO:0098693
GN016106	GN016106.1	Q9Z1C7	60.4	245	248	436	6.12e-104	311	RPGF4_RAT	Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII)	Rattus norvegicus (Rat)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; calcium-ion regulated exocytosis [GO:0017156]; cellular response to nerve growth factor stimulus [GO:1990090]; ganglion development [GO:0061548]; heart development [GO:0007507]; hormone secretion [GO:0046879]; insulin secretion [GO:0030073]; negative regulation of synaptic transmission [GO:0050805]; positive regulation of neuronal action potential [GO:1904457]; positive regulation of protein secretion [GO:0050714]; positive regulation of smooth muscle cell migration [GO:0014911]; Rap protein signal transduction [GO:0032486]; regulation of dendrite development [GO:0050773]; regulation of exocytosis [GO:0017157]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of postsynapse organization [GO:0099175]; regulation of synaptic vesicle cycle [GO:0098693]; response to benzene [GO:1901423]; spinal cord development [GO:0021510]	cAMP binding [GO:0030552]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cone cell pedicle [GO:0044316]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; neuronal cell body [GO:0043025]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]	GO:0001750; GO:0001917; GO:0005085; GO:0005829; GO:0005886; GO:0005903; GO:0007188; GO:0007189; GO:0007507; GO:0014069; GO:0014911; GO:0016323; GO:0016324; GO:0017156; GO:0017157; GO:0021510; GO:0030073; GO:0030424; GO:0030425; GO:0030426; GO:0030552; GO:0030674; GO:0031267; GO:0032486; GO:0032991; GO:0043025; GO:0043197; GO:0044316; GO:0044877; GO:0046879; GO:0050714; GO:0050773; GO:0050805; GO:0060076; GO:0061548; GO:0098686; GO:0098693; GO:0098696; GO:0098793; GO:0098978; GO:0099175; GO:1901423; GO:1904457; GO:1990090
GN016107	GN016107.1	Q8CEL2	37.8	111	111	1252	5.21e-23	95.5	CFA61_MOUSE	Cilia- and flagella-associated protein 61	Mus musculus (Mouse)	cilium movement [GO:0003341]; cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; sperm flagellum assembly [GO:0120316]; spermatid nucleus elongation [GO:0007290]		axoneme [GO:0005930]; manchette [GO:0002177]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; radial spoke stalk [GO:0001536]; sperm flagellum [GO:0036126]	GO:0001534; GO:0001536; GO:0002177; GO:0003341; GO:0005930; GO:0007290; GO:0030317; GO:0031514; GO:0036126; GO:0044782; GO:0120316
GN016108	GN016108.1	Q60613	43.9	180	246	410	5.58e-37	137	AA2AR_MOUSE	Adenosine receptor A2a	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; astrocyte activation [GO:0048143]; eating behavior [GO:0042755]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; G protein-coupled receptor signaling pathway [GO:0007186]; inhibition of non-skeletal tissue mineralization [GO:0140928]; inhibitory postsynaptic potential [GO:0060080]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of vascular permeability [GO:0043116]; neuron projection morphogenesis [GO:0048812]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein secretion [GO:0050714]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of urine volume [GO:0035810]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of calcium ion transport [GO:0051924]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of norepinephrine secretion [GO:0014061]; response to alkaloid [GO:0043279]; response to amphetamine [GO:0001975]; response to caffeine [GO:0031000]; response to purine-containing compound [GO:0014074]; response to xenobiotic stimulus [GO:0009410]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission, dopaminergic [GO:0001963]; synaptic transmission, glutamatergic [GO:0035249]; vasodilation [GO:0042311]	alpha-actinin binding [GO:0051393]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; G protein-coupled adenosine receptor activity [GO:0001609]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein-containing complex binding [GO:0044877]; type 5 metabotropic glutamate receptor binding [GO:0031802]	asymmetric synapse [GO:0032279]; axolemma [GO:0030673]; axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; intermediate filament [GO:0005882]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]	GO:0001609; GO:0001963; GO:0001973; GO:0001975; GO:0005516; GO:0005882; GO:0005886; GO:0006355; GO:0006469; GO:0007186; GO:0007189; GO:0007200; GO:0007271; GO:0007626; GO:0008285; GO:0008289; GO:0009410; GO:0014049; GO:0014057; GO:0014061; GO:0014074; GO:0016020; GO:0019899; GO:0030424; GO:0030425; GO:0030673; GO:0031000; GO:0031802; GO:0032230; GO:0032279; GO:0035249; GO:0035810; GO:0042311; GO:0042734; GO:0042755; GO:0042802; GO:0043025; GO:0043116; GO:0043279; GO:0043524; GO:0044877; GO:0045211; GO:0045938; GO:0046636; GO:0048143; GO:0048786; GO:0048812; GO:0050714; GO:0050728; GO:0051393; GO:0051881; GO:0051899; GO:0051924; GO:0051968; GO:0060079; GO:0060080; GO:0060134; GO:0070374; GO:0098978; GO:0099171; GO:0140928; GO:1900273; GO:2001235
GN016109	GN016109.1	Q8CEL2	43.0	93	102	1252	2.52e-20	87.4	CFA61_MOUSE	Cilia- and flagella-associated protein 61	Mus musculus (Mouse)	cilium movement [GO:0003341]; cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; sperm flagellum assembly [GO:0120316]; spermatid nucleus elongation [GO:0007290]		axoneme [GO:0005930]; manchette [GO:0002177]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; radial spoke stalk [GO:0001536]; sperm flagellum [GO:0036126]	GO:0001534; GO:0001536; GO:0002177; GO:0003341; GO:0005930; GO:0007290; GO:0030317; GO:0031514; GO:0036126; GO:0044782; GO:0120316
GN016110	GN016110.1	Q8NHU2	50.1	818	823	1237	1.16e-248	731	CFA61_HUMAN	Cilia- and flagella-associated protein 61	Homo sapiens (Human)	cilium movement [GO:0003341]; cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; sperm flagellum assembly [GO:0120316]; sperm mitochondrial sheath assembly [GO:0120317]		axoneme [GO:0005930]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]	GO:0003341; GO:0005930; GO:0030317; GO:0031514; GO:0036126; GO:0044782; GO:0120316; GO:0120317
GN016111	GN016111.1	Q803R7	63.9	588	558	753	5.35e-223	638	CRNL1_DANRE	Crooked neck-like protein 1 (Crooked neck pre-mRNA splicing factor 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	spliceosomal complex assembly [GO:0000245]		nuclear speck [GO:0016607]; post-mRNA release spliceosomal complex [GO:0071014]; Prp19 complex [GO:0000974]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000245; GO:0000974; GO:0016607; GO:0071007; GO:0071014
GN016112	GN016112.1	Q5PR68	58.1	129	178	954	5.98e-43	155	CE112_MOUSE	Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46)	Mus musculus (Mouse)	gene expression [GO:0010467]; receptor localization to synapse [GO:0097120]; regulation of translation [GO:0006417]; single fertilization [GO:0007338]; spermatid development [GO:0007286]	molecular condensate scaffold activity [GO:0140693]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; inhibitory synapse [GO:0060077]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sperm head-tail coupling apparatus [GO:0120212]	GO:0005634; GO:0005737; GO:0005813; GO:0005814; GO:0005886; GO:0006417; GO:0007286; GO:0007338; GO:0010467; GO:0036464; GO:0060077; GO:0097120; GO:0120212; GO:0140693
GN016113	GN016113.1	Q8N8E3	50.4	280	340	955	1.45e-66	228	CE112_HUMAN	Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46)	Homo sapiens (Human)		molecular condensate scaffold activity [GO:0140693]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; inhibitory synapse [GO:0060077]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sperm head-tail coupling apparatus [GO:0120212]	GO:0005634; GO:0005737; GO:0005813; GO:0005814; GO:0005886; GO:0036464; GO:0060077; GO:0120212; GO:0140693
GN016114	GN016114.1	Q8N8E3	50.7	71	94	955	3.11e-09	55.5	CE112_HUMAN	Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46)	Homo sapiens (Human)		molecular condensate scaffold activity [GO:0140693]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; inhibitory synapse [GO:0060077]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sperm head-tail coupling apparatus [GO:0120212]	GO:0005634; GO:0005737; GO:0005813; GO:0005814; GO:0005886; GO:0036464; GO:0060077; GO:0120212; GO:0140693
GN016115	GN016115.1	Q8N8E3	39.8	171	192	955	1.89e-31	123	CE112_HUMAN	Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46)	Homo sapiens (Human)		molecular condensate scaffold activity [GO:0140693]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; inhibitory synapse [GO:0060077]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sperm head-tail coupling apparatus [GO:0120212]	GO:0005634; GO:0005737; GO:0005813; GO:0005814; GO:0005886; GO:0036464; GO:0060077; GO:0120212; GO:0140693
GN016116	GN016116.1	Q5PR68	58.1	129	225	954	3.09e-42	155	CE112_MOUSE	Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46)	Mus musculus (Mouse)	gene expression [GO:0010467]; receptor localization to synapse [GO:0097120]; regulation of translation [GO:0006417]; single fertilization [GO:0007338]; spermatid development [GO:0007286]	molecular condensate scaffold activity [GO:0140693]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; inhibitory synapse [GO:0060077]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sperm head-tail coupling apparatus [GO:0120212]	GO:0005634; GO:0005737; GO:0005813; GO:0005814; GO:0005886; GO:0006417; GO:0007286; GO:0007338; GO:0010467; GO:0036464; GO:0060077; GO:0097120; GO:0120212; GO:0140693
GN016117	GN016117.1	Q8N8E3	50.4	280	340	955	1.45e-66	228	CE112_HUMAN	Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46)	Homo sapiens (Human)		molecular condensate scaffold activity [GO:0140693]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; inhibitory synapse [GO:0060077]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sperm head-tail coupling apparatus [GO:0120212]	GO:0005634; GO:0005737; GO:0005813; GO:0005814; GO:0005886; GO:0036464; GO:0060077; GO:0120212; GO:0140693
GN016118	GN016118.1	Q8N8E3	39.2	367	409	955	2.00e-59	211	CE112_HUMAN	Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46)	Homo sapiens (Human)		molecular condensate scaffold activity [GO:0140693]	centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; inhibitory synapse [GO:0060077]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sperm head-tail coupling apparatus [GO:0120212]	GO:0005634; GO:0005737; GO:0005813; GO:0005814; GO:0005886; GO:0036464; GO:0060077; GO:0120212; GO:0140693
GN016119	GN016119.1	Q4R6I6	66.7	54	90	86	1.34e-16	70.9	SRP09_MACFA	Signal recognition particle 9 kDa protein (SRP9)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	negative regulation of translational elongation [GO:0045900]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]	7S RNA binding [GO:0008312]	cytosol [GO:0005829]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]	GO:0005786; GO:0005829; GO:0006614; GO:0008312; GO:0045900
GN016130	GN016130.1	Q9M2U3	28.9	218	220	406	5.10e-20	90.5	ALPL_ARATH	Protein ALP1-like (EC 3.1.-.-)	Arabidopsis thaliana (Mouse-ear cress)			histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634
GN016133	GN016133.1	O93530	29.8	272	261	1436	2.18e-24	105	WRN_XENLA	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Focus-forming activity 1) (FFA-1) (Werner syndrome protein homolog) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Xenopus laevis (African clawed frog)	DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; four-way junction helicase activity [GO:0009378]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000723; GO:0000724; GO:0000781; GO:0003676; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006259; GO:0006260; GO:0008408; GO:0009378; GO:0016887; GO:0030145; GO:0032392; GO:0043138
GN016135	GN016135.1	Q9M2U3	27.6	257	249	406	2.67e-23	100	ALPL_ARATH	Protein ALP1-like (EC 3.1.-.-)	Arabidopsis thaliana (Mouse-ear cress)			histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634
GN016137	GN016137.1	O93530	29.8	272	261	1436	2.18e-24	105	WRN_XENLA	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Focus-forming activity 1) (FFA-1) (Werner syndrome protein homolog) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Xenopus laevis (African clawed frog)	DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; four-way junction helicase activity [GO:0009378]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000723; GO:0000724; GO:0000781; GO:0003676; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006259; GO:0006260; GO:0008408; GO:0009378; GO:0016887; GO:0030145; GO:0032392; GO:0043138
GN016139	GN016139.1	Q29RY7	38.3	133	120	441	1.36e-16	77.4	FGL2_BOVIN	Fibroleukin (Fibrinogen-like protein 2)	Bos taurus (Bovine)		peptidase activator activity [GO:0016504]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]	GO:0009986; GO:0016504; GO:0031012
GN016141	GN016141.1	Q9M2U3	29.6	152	153	406	9.01e-13	67.8	ALPL_ARATH	Protein ALP1-like (EC 3.1.-.-)	Arabidopsis thaliana (Mouse-ear cress)			histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634
GN016142	GN016142.1	D8VNS7	47.8	184	285	345	6.14e-56	186	FCNV1_CERRY	Ryncolin-1	Cerberus rynchops (Dog-faced water snake)	complement activation, lectin pathway [GO:0001867]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0001867; GO:0003823; GO:0005102; GO:0005576; GO:0097367
GN016146	GN016146.1	Q071E0	34.4	128	731	344	8.48e-09	61.6	KT5AA_DANRE	N-lysine methyltransferase KMT5A-A (EC 2.1.1.-) (Histone-lysine N-methyltransferase KMT5A-A) (EC 2.1.1.361) (Lysine-specific methylase 5A-A) (SET domain-containing protein 8-A)	Danio rerio (Zebrafish) (Brachydanio rerio)	dorsal/ventral pattern formation [GO:0009953]; positive regulation of gene expression [GO:0010628]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone methyltransferase activity [GO:0042054]; protein-lysine N-methyltransferase activity [GO:0016279]	chromosome [GO:0005694]; nucleus [GO:0005634]; polytene chromosome [GO:0005700]	GO:0005634; GO:0005694; GO:0005700; GO:0006357; GO:0009953; GO:0010628; GO:0016279; GO:0042054; GO:0042799; GO:0043516; GO:0140944
GN016149	GN016149.1	Q68EY7	54.5	213	211	217	3.32e-56	180	C124A_XENLA	Coiled-coil domain-containing protein 124-A	Xenopus laevis (African clawed frog)	transcription by RNA polymerase II [GO:0006366]	transcription coactivator activity [GO:0003713]	centrosome [GO:0005813]; midbody [GO:0030496]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005813; GO:0006366; GO:0030496
GN016155	GN016155.1	Q9VZW5	28.1	324	484	549	8.94e-33	134	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN016160	GN016160.1	Q17QR8	29.5	146	219	349	1.42e-14	74.7	HARB1_BOVIN	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Bos taurus (Bovine)			cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005829; GO:0005886
GN016166	GN016166.1	Q5RCS0	44.3	799	765	839	4.38e-191	568	ATG9A_PONAB	Autophagy-related protein 9A (APG9-like 1)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; bone morphogenesis [GO:0060349]; piecemeal microautophagy of the nucleus [GO:0034727]; programmed necrotic cell death [GO:0097300]; protein localization to phagophore assembly site [GO:0034497]; reticulophagy [GO:0061709]	phospholipid scramblase activity [GO:0017128]	autophagosome membrane [GO:0000421]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagophore assembly site membrane [GO:0034045]; recycling endosome membrane [GO:0055038]; synaptic membrane [GO:0097060]; trans-Golgi network [GO:0005802]	GO:0000045; GO:0000139; GO:0000421; GO:0000422; GO:0005739; GO:0005789; GO:0005794; GO:0005802; GO:0017128; GO:0031902; GO:0031966; GO:0034045; GO:0034497; GO:0034727; GO:0055038; GO:0060349; GO:0061709; GO:0097060; GO:0097300
GN016170	GN016170.1	Q5BK75	25.1	431	486	461	1.52e-22	103	S46A3_RAT	Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)	Rattus norvegicus (Rat)	cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; vacuolar transmembrane transport [GO:0034486]	copper ion transmembrane transporter activity [GO:0005375]; transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]	GO:0005375; GO:0005765; GO:0022857; GO:0034486; GO:1904613
GN016171	GN016171.1	Q9DC26	25.2	369	454	460	5.84e-20	95.5	S46A3_MOUSE	Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)	Mus musculus (Mouse)	cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; vacuolar transmembrane transport [GO:0034486]	copper ion transmembrane transporter activity [GO:0005375]; transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]	GO:0005375; GO:0005765; GO:0022857; GO:0034486; GO:1904613
GN016174	GN016174.1	P86880	33.3	156	159	159	8.30e-21	86.3	NGB_CHAAC	Neuroglobin (Nitrite reductase) (EC 1.7.-.-)	Chaenocephalus aceratus (Blackfin icefish) (Chaenichthys aceratus)	cellular response to hypoxia [GO:0071456]	GDP-dissociation inhibitor activity [GO:0005092]; heme binding [GO:0020037]; nitrite reductase activity [GO:0098809]; oxygen binding [GO:0019825]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]	GO:0005092; GO:0005759; GO:0005829; GO:0019825; GO:0020037; GO:0071456; GO:0098809
GN016179	GN016179.1	P50991	76.5	514	536	539	2.31e-278	769	TCPD_HUMAN	T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding)	Homo sapiens (Human)	positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; scaRNA localization to Cajal body [GO:0090666]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; protein folding chaperone [GO:0044183]; RNA binding [GO:0003723]	cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; microtubule [GO:0005874]; zona pellucida receptor complex [GO:0002199]	GO:0002199; GO:0003723; GO:0005524; GO:0005737; GO:0005813; GO:0005829; GO:0005832; GO:0005874; GO:0006457; GO:0016887; GO:0032212; GO:0042470; GO:0044183; GO:0044297; GO:0050821; GO:0070062; GO:0090666; GO:0140662; GO:1904871; GO:1904874
GN016185	GN016185.1	Q0E908	20.8	501	827	818	2.11e-23	110	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN016190	GN016190.1	P08953	23.5	463	681	1097	2.96e-20	99.8	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN016191	GN016191.1	P08953	23.8	463	681	1097	3.50e-22	105	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN016193	GN016193.1	P08953	24.2	472	681	1097	2.86e-23	109	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN016195	GN016195.1	P55954	40.3	77	93	174	3.42e-18	77.4	COX5A_CAEEL	Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)	Caenorhabditis elegans	mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]		mitochondrial inner membrane [GO:0005743]; respiratory chain complex IV [GO:0045277]	GO:0005743; GO:0006123; GO:0045277
GN016198	GN016198.1	P49914	40.2	194	226	203	7.62e-42	144	MTHFS_HUMAN	5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)	Homo sapiens (Human)	folic acid catabolic process [GO:0046657]; folic acid metabolic process [GO:0046655]; folic acid-containing compound biosynthetic process [GO:0009396]; formate metabolic process [GO:0015942]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	5-formyltetrahydrofolate cyclo-ligase activity [GO:0030272]; ATP binding [GO:0005524]; folic acid binding [GO:0005542]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005524; GO:0005542; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0009396; GO:0015942; GO:0030272; GO:0035999; GO:0046653; GO:0046655; GO:0046657
GN016199	GN016199.1	A0A345BJN8	31.0	248	606	919	1.74e-24	112	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN016200	GN016200.1	Q9NPJ1	30.6	553	574	570	5.78e-71	241	MKKS_HUMAN	Molecular chaperone MKKS (Bardet-Biedl syndrome 6 protein) (McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin)	Homo sapiens (Human)	brain morphogenesis [GO:0048854]; cerebral cortex development [GO:0021987]; chaperone-mediated protein complex assembly [GO:0051131]; cilium assembly [GO:0060271]; convergent extension involved in gastrulation [GO:0060027]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; determination of left/right symmetry [GO:0007368]; developmental process [GO:0032502]; fat cell differentiation [GO:0045444]; gonad development [GO:0008406]; heart development [GO:0007507]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; melanosome transport [GO:0032402]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; photoreceptor cell maintenance [GO:0045494]; pigment granule aggregation in cell center [GO:0051877]; protein folding [GO:0006457]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; sensory perception of smell [GO:0007608]; social behavior [GO:0035176]; spermatid development [GO:0007286]; striatum development [GO:0021756]	ATP binding [GO:0005524]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinociliary basal body [GO:1902636]; motile cilium [GO:0031514]; nucleus [GO:0005634]	GO:0001947; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0006457; GO:0007286; GO:0007368; GO:0007507; GO:0007608; GO:0008406; GO:0021756; GO:0021766; GO:0021987; GO:0031514; GO:0032402; GO:0032502; GO:0035176; GO:0036064; GO:0038108; GO:0045444; GO:0045494; GO:0048854; GO:0050910; GO:0051131; GO:0051877; GO:0060027; GO:0060271; GO:0060296; GO:0061629; GO:1902636
GN016206	GN016206.1	Q6ZU80	29.9	371	1031	1094	6.24e-19	96.7	CE128_HUMAN	Centrosomal protein 128 (Cep128) (Centrosomal protein of 128 kDa)	Homo sapiens (Human)	intracellular protein localization [GO:0008104]; motile cilium assembly [GO:0044458]; negative regulation of cilium assembly [GO:1902018]; positive regulation of protein localization [GO:1903829]; regulation of gene expression [GO:0010468]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; sperm flagellum assembly [GO:0120316]		centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; sperm head-tail coupling apparatus [GO:0120212]; spindle pole [GO:0000922]	GO:0000922; GO:0005813; GO:0005814; GO:0008104; GO:0010468; GO:0017015; GO:0036064; GO:0044458; GO:0120103; GO:0120212; GO:0120316; GO:1902018; GO:1903829
GN016207	GN016207.1	Q8N5M4	31.9	91	143	171	7.70e-09	54.7	TTC9C_HUMAN	Tetratricopeptide repeat protein 9C (TPR repeat protein 9C)	Homo sapiens (Human)				
GN016208	GN016208.1	Q3T0V3	66.7	105	111	218	5.80e-45	147	EIF3K_BOVIN	Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (eIF-3 p25)	Bos taurus (Bovine)	formation of cytoplasmic translation initiation complex [GO:0001732]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; nucleus [GO:0005634]	GO:0001732; GO:0003723; GO:0003743; GO:0005634; GO:0005829; GO:0005852; GO:0006413; GO:0006446; GO:0016282; GO:0033290; GO:0043022
GN016209	GN016209.1	Q8NI22	51.0	100	167	146	1.75e-25	98.2	MCFD2_HUMAN	Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein)	Homo sapiens (Human)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]	calcium ion binding [GO:0005509]	cargo receptor complex [GO:0062137]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]	GO:0005509; GO:0005789; GO:0005794; GO:0006888; GO:0012507; GO:0033116; GO:0062137
GN016210	GN016210.1	Q641K1	42.5	1179	1234	1218	2.53e-287	845	CBPC1_MOUSE	Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1) (Protein deglutamylase CCP1)	Mus musculus (Mouse)	adult walking behavior [GO:0007628]; anterograde axonal transport of mitochondrion [GO:0098957]; axonal transport [GO:0098930]; C-terminal protein deglutamylation [GO:0035609]; central nervous system neuron development [GO:0021954]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum development [GO:0021549]; eye photoreceptor cell differentiation [GO:0001754]; mitochondrion organization [GO:0007005]; negative regulation of cell population proliferation [GO:0008285]; neuromuscular process [GO:0050905]; olfactory bulb development [GO:0021772]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610]; proteolysis [GO:0006508]; retina development in camera-type eye [GO:0060041]; retrograde axonal transport of mitochondrion [GO:0098958]	metallocarboxypeptidase activity [GO:0004181]; peptidase activity [GO:0008233]; tubulin binding [GO:0015631]; zinc ion binding [GO:0008270]	axon cytoplasm [GO:1904115]; centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0001754; GO:0004181; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0005929; GO:0006508; GO:0007005; GO:0007628; GO:0008233; GO:0008270; GO:0008285; GO:0015630; GO:0015631; GO:0021549; GO:0021680; GO:0021702; GO:0021772; GO:0021954; GO:0034451; GO:0035608; GO:0035609; GO:0035610; GO:0036064; GO:0050905; GO:0060041; GO:0098930; GO:0098957; GO:0098958; GO:1904115; GO:2000060
GN016211	GN016211.1	O08762	58.3	103	667	761	4.51e-31	133	NETR_MOUSE	Neurotrypsin (EC 3.4.21.-) (Brain-specific serine protease 3) (BSSP-3) (Motopsin) (Serine protease 12)	Mus musculus (Mouse)	exocytosis [GO:0006887]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]	axon [GO:0030424]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; synaptic cleft [GO:0043083]; terminal bouton [GO:0043195]	GO:0004252; GO:0005886; GO:0006508; GO:0006887; GO:0008233; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195; GO:0045202; GO:0098685; GO:0098793; GO:0098978
GN016218	GN016218.1	Q6AXS8	44.7	152	199	296	5.20e-41	143	TPGS2_RAT	Tubulin polyglutamylase complex subunit 2 (PGs2)	Rattus norvegicus (Rat)	microtubule cytoskeleton organization [GO:0000226]	protein-macromolecule adaptor activity [GO:0030674]	centriolar satellite [GO:0034451]; microtubule [GO:0005874]	GO:0000226; GO:0005874; GO:0030674; GO:0034451
GN016219	GN016219.1	D2GXS7	25.8	182	429	744	3.29e-10	65.9	TRIM2_AILME	Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2)	Ailuropoda melanoleuca (Giant panda)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0043161; GO:0043523; GO:0061630
GN016222	GN016222.1	Q4KLI9	26.1	629	683	569	3.01e-36	147	FBXW5_RAT	F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)	Rattus norvegicus (Rat)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	protein kinase binding [GO:0019901]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005737; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0080008
GN016223	GN016223.1	Q6NWW5	44.4	612	1407	1356	9.88e-137	457	KIF24_MOUSE	Kinesin-like protein KIF24	Mus musculus (Mouse)	cilium assembly [GO:0060271]; microtubule depolymerization [GO:0007019]; microtubule-based movement [GO:0007018]; negative regulation of cilium assembly [GO:1902018]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	centriole [GO:0005814]; centrosome [GO:0005813]; protein-containing complex [GO:0032991]	GO:0003777; GO:0005524; GO:0005813; GO:0005814; GO:0007018; GO:0007019; GO:0008017; GO:0032991; GO:0042802; GO:0060271; GO:1902018
GN016224	GN016224.1	Q2V2K5	34.5	145	157	407	6.11e-21	90.9	GNRHR_OCTVU	Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R) (oct-GnRHR)	Octopus vulgaris (Common octopus)	cellular response to hormone stimulus [GO:0032870]	G protein-coupled receptor activity [GO:0004930]; peptide binding [GO:0042277]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0032870; GO:0042277
GN016226	GN016226.1	Q9D6N1	46.3	67	158	262	3.62e-13	68.2	CAH13_MOUSE	Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonate dehydratase XIII) (Carbonic anhydrase XIII) (CA-XIII)	Mus musculus (Mouse)		carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; myelin sheath [GO:0043209]	GO:0004089; GO:0005737; GO:0005829; GO:0008270; GO:0043209
GN016227	GN016227.1	Q642J4	37.6	101	238	317	3.38e-12	68.2	IMPCT_DANRE	Protein IMPACT (Imprinted and ancient gene protein homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to amino acid starvation [GO:0034198]; GCN2-mediated signaling [GO:0140469]; intracellular signal transduction [GO:0035556]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron projection extension [GO:1990138]; positive regulation of neuron differentiation [GO:0045666]; regulation of cytoplasmic translational initiation in response to stress [GO:1990611]; regulation of translational initiation [GO:0006446]	protein sequestering activity [GO:0140311]	cytoplasm [GO:0005737]	GO:0000122; GO:0005737; GO:0006446; GO:0034198; GO:0035556; GO:0045666; GO:0140311; GO:0140469; GO:1990138; GO:1990611
GN016228	GN016228.1	P15428	43.0	121	169	266	1.13e-23	96.7	PGDH_HUMAN	15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Eicosanoid/docosanoid dehydrogenase [NAD(+)]) (EC 1.1.1.-, EC 1.1.1.232) (Prostaglandin dehydrogenase 1) (Short chain dehydrogenase/reductase family 36C member 1)	Homo sapiens (Human)	ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; kidney development [GO:0001822]; lipoxin biosynthetic process [GO:2001301]; lipoxygenase pathway [GO:0019372]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; positive regulation of apoptotic process [GO:0043065]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostaglandin catabolic process [GO:1905344]; prostaglandin metabolic process [GO:0006693]; regulation of prostaglandin catabolic process [GO:1905828]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; thrombin-activated receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179]	15-hydroxyicosatetraenoate dehydrogenase activity [GO:0047034]; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity [GO:0016404]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E receptor activity [GO:0004957]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0001822; GO:0004957; GO:0005737; GO:0005829; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016323; GO:0016404; GO:0016616; GO:0019372; GO:0030728; GO:0032355; GO:0032496; GO:0042802; GO:0043065; GO:0045471; GO:0045786; GO:0047034; GO:0051287; GO:0070062; GO:0070403; GO:0070493; GO:0097070; GO:1904707; GO:1905344; GO:1905828; GO:2001301
GN016233	GN016233.1	Q501Z5	50.9	436	439	500	3.27e-135	400	GTPB3_DANRE	5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial (EC 3.6.1.-) (GTP-binding protein 3) (tRNA modification GTPase GTPBP3, mitochondrial)	Danio rerio (Zebrafish) (Brachydanio rerio)	embryonic organ development [GO:0048568]; mitochondrial alanyl-tRNA aminoacylation [GO:0070143]; mitochondrial leucyl-tRNA aminoacylation [GO:0070153]; mitochondrial lysyl-tRNA aminoacylation [GO:0070154]; mitochondrial methionyl-tRNA aminoacylation [GO:0070155]; mitochondrial tRNA modification [GO:0070900]; mitochondrial tRNA wobble uridine modification [GO:0070899]; mitochondrial tryptophanyl-tRNA aminoacylation [GO:0070183]; mitochondrial tyrosyl-tRNA aminoacylation [GO:0070184]; tRNA methylation [GO:0030488]; tRNA stabilization [GO:0036416]; tRNA wobble uridine modification [GO:0002098]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0002098; GO:0003924; GO:0005525; GO:0005737; GO:0005739; GO:0030488; GO:0036416; GO:0048568; GO:0070143; GO:0070153; GO:0070154; GO:0070155; GO:0070183; GO:0070184; GO:0070899; GO:0070900
GN016236	GN016236.1	Q8K0U4	31.1	630	590	675	2.05e-89	293	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN016237	GN016237.1	Q8BNU0	45.6	465	465	468	1.72e-79	257	ARMC6_MOUSE	Armadillo repeat-containing protein 6	Mus musculus (Mouse)	hematopoietic progenitor cell differentiation [GO:0002244]		cytosol [GO:0005829]	GO:0002244; GO:0005829
GN016238	GN016238.1	Q6GQQ9	43.7	483	1089	843	1.70e-100	340	OTU7B_HUMAN	OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)	Homo sapiens (Human)	mucosal immune response [GO:0002385]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of TORC2 signaling [GO:1904515]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type peptidase activity [GO:0008234]; DNA binding [GO:0003677]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000122; GO:0002385; GO:0003677; GO:0004843; GO:0005634; GO:0005737; GO:0005829; GO:0008234; GO:0008270; GO:0016579; GO:0032717; GO:0035871; GO:0043124; GO:0070530; GO:0070536; GO:0071108; GO:0071947; GO:1900181; GO:1904262; GO:1904515; GO:1990380
GN016240	GN016240.1	Q8UWA5	49.8	259	289	260	7.48e-83	253	CAH2_PSEHK	Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II)	Pseudaspius hakonensis (Big-scaled redfin) (Tribolodon hakonensis)	carbon dioxide transport [GO:0015670]; regulation of pH [GO:0006885]	carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004089; GO:0005737; GO:0005886; GO:0006885; GO:0008270; GO:0015670
GN016247	GN016247.1	Q94899	76.9	65	256	444	1.32e-24	104	CSN2_DROME	COP9 signalosome complex subunit 2 (Dch2) (Signalosome subunit 2) (Alien protein)	Drosophila melanogaster (Fruit fly)	eclosion [GO:0007562]; female germ-line stem cell population maintenance [GO:0036099]; germ cell development [GO:0007281]; germarium-derived cystoblast division [GO:0048142]; male germ-line cyst encapsulation [GO:0048140]; negative regulation of DNA-templated transcription [GO:0045892]; protein deneddylation [GO:0000338]; protein stabilization [GO:0050821]; regulation of protein neddylation [GO:2000434]	nuclear receptor binding [GO:0016922]; transcription corepressor activity [GO:0003714]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; repressor ecdysone receptor complex [GO:0008231]	GO:0000338; GO:0003714; GO:0005737; GO:0007281; GO:0007562; GO:0008180; GO:0008231; GO:0016922; GO:0036099; GO:0045892; GO:0048140; GO:0048142; GO:0050821; GO:2000434
GN016255	GN016255.1	Q9TTF0	53.8	342	380	411	1.24e-110	332	NR2E3_BOVIN	Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor)	Bos taurus (Bovine)	neuron differentiation [GO:0030182]; positive regulation of transcription by RNA polymerase II [GO:0045944]	nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0000978; GO:0004879; GO:0005634; GO:0008270; GO:0030182; GO:0045944
GN016256	GN016256.1	Q0IHW3	36.7	758	690	712	1.95e-119	376	SMAG1_XENTR	Protein Smaug homolog 1 (Smaug 1) (Sterile alpha motif domain-containing protein 4A)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	regulation of mRNA stability [GO:0043488]	RNA binding [GO:0003723]; translation repressor activity [GO:0030371]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; synapse [GO:0045202]	GO:0003723; GO:0005737; GO:0030371; GO:0030425; GO:0043488; GO:0045202
GN016257	GN016257.1	Q9BQT8	62.4	295	306	299	1.93e-133	383	ODC_HUMAN	Mitochondrial 2-oxodicarboxylate carrier (ODC) (Mitochondrial 2-oxoadipate carrier) (Solute carrier family 25 member 21)	Homo sapiens (Human)	L-lysine catabolic process [GO:0019477]; mitochondrial alpha-ketoglutarate transmembrane transport [GO:1990550]	alpha-ketoglutarate transmembrane transporter activity [GO:0015139]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0015139; GO:0019477; GO:1990550
GN016258	GN016258.1	Q29RU1	57.9	126	128	139	7.84e-41	135	RT12_BOVIN	Small ribosomal subunit protein uS12m (28S ribosomal protein S12, mitochondrial) (MRP-S12) (S12mt)	Bos taurus (Bovine)	mitochondrial translation [GO:0032543]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; ribosome [GO:0005840]	GO:0003735; GO:0005739; GO:0005743; GO:0005763; GO:0005840; GO:0006412; GO:0032543
GN016259	GN016259.1	B2RY56	76.7	43	120	838	2.25e-14	71.2	RBM25_MOUSE	RNA-binding protein 25 (RNA-binding motif protein 25)	Mus musculus (Mouse)	regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]	GO:0000381; GO:0003729; GO:0005737; GO:0016607; GO:0042981
GN016262	GN016262.1	P49756	58.2	407	606	843	9.62e-91	301	RBM25_HUMAN	RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7)	Homo sapiens (Human)	regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	GO:0000381; GO:0003723; GO:0003729; GO:0005654; GO:0005737; GO:0016607; GO:0042981
GN016280	GN016280.1	Q9I8C7	49.3	282	420	452	4.15e-99	306	ACH10_CHICK	Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)	Gallus gallus (Chicken)	calcium ion transport [GO:0006816]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; transmembrane transporter complex [GO:1902495]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0050910; GO:0097060; GO:1902495
GN016285	GN016285.1	Q3T0Y3	36.1	269	296	296	1.38e-51	174	ST1B1_BOVIN	Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase family cytosolic 1B member 1)	Bos taurus (Bovine)	sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]	aryl sulfotransferase activity [GO:0004062]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004062; GO:0005737; GO:0005829; GO:0042403; GO:0051923
GN016286	GN016286.1	Q2NL67	44.1	637	758	630	1.95e-154	466	PARP6_HUMAN	Protein mono-ADP-ribosyltransferase PARP6 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 17) (ARTD17) (Poly [ADP-ribose] polymerase 6) (PARP-6)	Homo sapiens (Human)	endoplasmic reticulum unfolded protein response [GO:0030968]; positive regulation of dendrite morphogenesis [GO:0050775]; protein auto-ADP-ribosylation [GO:0070213]	kinase binding [GO:0019900]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; protein serine/threonine kinase activator activity [GO:0043539]	endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; nuclear envelope [GO:0005635]	GO:0003950; GO:0005635; GO:0016020; GO:0019900; GO:0030968; GO:0043539; GO:0050775; GO:0070213; GO:0071782; GO:0140803; GO:0140806
GN016289	GN016289.1	P48039	24.1	270	369	350	2.43e-12	70.9	MTR1A_HUMAN	Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)	Homo sapiens (Human)	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; mating behavior [GO:0007617]	G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; melatonin receptor activity [GO:0008502]	plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004930; GO:0005886; GO:0007187; GO:0007193; GO:0007617; GO:0007623; GO:0008502; GO:0042562; GO:0043235
GN016290	GN016290.1	V5NAL9	33.5	650	713	899	2.73e-99	328	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN016291	GN016291.1	V5NAL9	35.2	684	713	899	9.07e-104	340	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN016293	GN016293.1	Q9VAY7	57.6	368	335	359	2.83e-128	374	FAM50_DROME	Protein FAM50 homolog	Drosophila melanogaster (Fruit fly)	chromatin organization [GO:0006325]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]	GO:0003723; GO:0005654; GO:0006325
GN016294	GN016294.1	Q8RB67	56.1	57	228	384	5.17e-14	73.6	DNAJ_CALS4	Chaperone protein DnaJ	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)	protein refolding [GO:0042026]; response to heat [GO:0009408]	ATP binding [GO:0005524]; heat shock protein binding [GO:0031072]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005524; GO:0005737; GO:0008270; GO:0009408; GO:0031072; GO:0042026
GN016295	GN016295.1	Q6NXP6	34.4	346	366	359	2.89e-49	172	NXRD1_HUMAN	NADP-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) (Pyrroline-5-carboxylate reductase-like protein C14orf148)	Homo sapiens (Human)	L-proline biosynthetic process [GO:0055129]	pyrroline-5-carboxylate reductase activity [GO:0004735]		GO:0004735; GO:0055129
GN016299	GN016299.1	Q0IH86	50.5	273	289	282	3.82e-103	305	SLX1_XENLA	Structure-specific endonuclease subunit slx1 (EC 3.1.-.-) (GIY-YIG domain-containing protein 1)	Xenopus laevis (African clawed frog)	double-strand break repair via homologous recombination [GO:0000724]; regulation of telomere maintenance [GO:0032204]; t-circle formation [GO:0090656]	5'-flap endonuclease activity [GO:0017108]; crossover junction DNA endonuclease activity [GO:0008821]	Slx1-Slx4 complex [GO:0033557]	GO:0000724; GO:0008821; GO:0017108; GO:0032204; GO:0033557; GO:0090656
GN016301	GN016301.1	Q60803	38.2	570	560	567	1.76e-109	341	TRAF3_MOUSE	TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (RING-type E3 ubiquitin transferase TRAF3)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cell surface receptor signaling pathway [GO:0007166]; mRNA transcription [GO:0009299]; positive regulation of type I interferon production [GO:0032481]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; endosome [GO:0005768]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]	GO:0001817; GO:0002224; GO:0004842; GO:0005164; GO:0005737; GO:0005739; GO:0005768; GO:0007166; GO:0008063; GO:0008270; GO:0009299; GO:0009898; GO:0010008; GO:0019901; GO:0019903; GO:0030162; GO:0031625; GO:0031996; GO:0032481; GO:0032648; GO:0033209; GO:0034142; GO:0035591; GO:0035631; GO:0042802; GO:0042981; GO:0043122; GO:0050688; GO:0061630; GO:0140374
GN016302	GN016302.1	Q810V0	41.7	662	795	681	6.62e-105	340	MPP10_MOUSE	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10)	Mus musculus (Mouse)	ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]		chromosome [GO:0005694]; Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]	GO:0005694; GO:0005730; GO:0005732; GO:0006364; GO:0032040; GO:0034457; GO:0042274
GN016309	GN016309.1	A4IFB4	32.5	255	253	289	3.19e-37	135	KCTD7_BOVIN	BTB/POZ domain-containing protein KCTD7	Bos taurus (Bovine)	membrane hyperpolarization [GO:0060081]; protein homooligomerization [GO:0051260]		cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0005829; GO:0005886; GO:0051260; GO:0060081
GN016310	GN016310.1	Q8BGQ7	39.2	835	873	968	1.96e-175	535	SYAC_MOUSE	Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Protein sticky) (Sti)	Mus musculus (Mouse)	alanyl-tRNA aminoacylation [GO:0006419]; cerebellar Purkinje cell layer development [GO:0021680]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; hippo signaling [GO:0035329]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; neuromuscular process [GO:0050905]; neuromuscular process controlling balance [GO:0050885]; positive regulation of hippo signaling [GO:0035332]; regulation of cytoplasmic translational fidelity [GO:0140018]; tRNA modification [GO:0006400]	alanine-tRNA ligase activity [GO:0004813]; amino acid binding [GO:0016597]; aminoacyl-tRNA deacylase activity [GO:0002161]; ATP binding [GO:0005524]; peptide lactyltransferase (ATP-dependent) activity [GO:0141207]; Ser-tRNA(Ala) deacylase activity [GO:0002196]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000049; GO:0002161; GO:0002196; GO:0004813; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006400; GO:0006419; GO:0008270; GO:0016597; GO:0021680; GO:0030330; GO:0035329; GO:0035332; GO:0043524; GO:0050885; GO:0050905; GO:0140018; GO:0141207; GO:1901797
GN016311	GN016311.1	V5NAL9	27.3	652	574	899	9.82e-63	225	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN016313	GN016313.1	A5D7J3	41.7	103	217	452	1.02e-12	69.7	KNOP1_BOVIN	Lysine-rich nucleolar protein 1 (Testis-specific gene 118 protein)	Bos taurus (Bovine)			nucleolus [GO:0005730]	GO:0005730
GN016314	GN016314.1	Q96KP1	35.6	104	466	924	8.23e-11	68.2	EXOC2_HUMAN	Exocyst complex component 2 (Exocyst complex component Sec5)	Homo sapiens (Human)	exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; regulation of entry of bacterium into host cell [GO:2000535]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	GTP-dependent protein binding [GO:0030742]; protein kinase binding [GO:0019901]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0000145; GO:0000281; GO:0005829; GO:0005886; GO:0006887; GO:0006893; GO:0006904; GO:0016020; GO:0019901; GO:0030742; GO:0031267; GO:0090148; GO:0090522; GO:0090543; GO:2000535
GN016316	GN016316.1	Q49YE0	30.3	152	154	167	1.22e-11	62.4	Y1056_STAS1	Putative universal stress protein SSP1056	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)			cytoplasm [GO:0005737]	GO:0005737
GN016319	GN016319.1	Q5K4L6	42.7	96	96	683	3.85e-18	80.9	S27A3_HUMAN	Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3) (EC 6.2.1.-)	Homo sapiens (Human)	fatty acid transport [GO:0015908]; long-chain fatty acid metabolic process [GO:0001676]	arachidonate-CoA ligase activity [GO:0047676]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0001676; GO:0004467; GO:0005739; GO:0005789; GO:0005886; GO:0015908; GO:0016020; GO:0031957; GO:0031966; GO:0047676
GN016321	GN016321.1	O88561	40.6	96	96	667	2.20e-16	75.9	S27A3_MOUSE	Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3) (EC 6.2.1.-)	Mus musculus (Mouse)	acyl-CoA metabolic process [GO:0006637]; fatty acid transport [GO:0015908]; long-chain fatty acid metabolic process [GO:0001676]	arachidonate-CoA ligase activity [GO:0047676]; fatty-acyl-CoA synthase activity [GO:0004321]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0001676; GO:0004321; GO:0004467; GO:0005739; GO:0005759; GO:0005783; GO:0005789; GO:0005886; GO:0006637; GO:0015908; GO:0031957; GO:0031966; GO:0047676
GN016323	GN016323.1	Q5XIG6	57.5	447	465	458	1.06e-178	511	GALK2_RAT	N-acetylgalactosamine kinase (EC 2.7.1.157) (GalNAc kinase) (Galactokinase 2)	Rattus norvegicus (Rat)	carbohydrate phosphorylation [GO:0046835]; galactose metabolic process [GO:0006012]; nucleoside phosphate metabolic process [GO:0006753]; purine-containing compound metabolic process [GO:0072521]	ATP binding [GO:0005524]; galactokinase activity [GO:0004335]; N-acetylgalactosamine kinase activity [GO:0033858]	cytoplasm [GO:0005737]	GO:0004335; GO:0005524; GO:0005737; GO:0006012; GO:0006753; GO:0033858; GO:0046835; GO:0072521
GN016324	GN016324.1	P82924	47.5	99	543	435	3.78e-19	93.6	RT30_BOVIN	Large ribosomal subunit protein mL65 (28S ribosomal protein S30, mitochondrial) (MRP-S30) (S30mt)	Bos taurus (Bovine)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]	GO:0003735; GO:0005743; GO:0005762; GO:0006412
GN016325	GN016325.1	P82915	47.7	109	177	135	1.86e-33	118	RT16_BOVIN	Small ribosomal subunit protein bS16m (28S ribosomal protein S16, mitochondrial) (MRP-S16) (S16mt)	Bos taurus (Bovine)	mitochondrial translation [GO:0032543]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005763; GO:0032543
GN016328	GN016328.1	Q60803	38.9	529	563	567	6.01e-118	363	TRAF3_MOUSE	TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (RING-type E3 ubiquitin transferase TRAF3)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cell surface receptor signaling pathway [GO:0007166]; mRNA transcription [GO:0009299]; positive regulation of type I interferon production [GO:0032481]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; endosome [GO:0005768]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]	GO:0001817; GO:0002224; GO:0004842; GO:0005164; GO:0005737; GO:0005739; GO:0005768; GO:0007166; GO:0008063; GO:0008270; GO:0009299; GO:0009898; GO:0010008; GO:0019901; GO:0019903; GO:0030162; GO:0031625; GO:0031996; GO:0032481; GO:0032648; GO:0033209; GO:0034142; GO:0035591; GO:0035631; GO:0042802; GO:0042981; GO:0043122; GO:0050688; GO:0061630; GO:0140374
GN016329	GN016329.1	Q17RS7	29.5	380	483	908	3.69e-38	152	GEN_HUMAN	Flap endonuclease GEN homolog 1 (EC 3.1.-.-)	Homo sapiens (Human)	double-strand break repair via homologous recombination [GO:0000724]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of centrosome duplication [GO:0010824]; replication fork processing [GO:0031297]; resolution of DNA recombination intermediates [GO:0071139]; resolution of mitotic recombination intermediates [GO:0071140]	5'-flap endonuclease activity [GO:0017108]; crossover junction DNA endonuclease activity [GO:0008821]; four-way junction DNA binding [GO:0000400]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]	centrosome [GO:0005813]; nucleoplasm [GO:0005654]	GO:0000287; GO:0000400; GO:0000724; GO:0005654; GO:0005813; GO:0008821; GO:0010824; GO:0017108; GO:0031297; GO:0042803; GO:0071139; GO:0071140; GO:0090267
GN016330	GN016330.1	A2YH60	40.9	154	219	419	6.12e-32	123	CCB22_ORYSI	Cyclin-B2-2 (CycOs2) (G2/mitotic-specific cyclin-B2-2) (CycB2;2)	Oryza sativa subsp. indica (Rice)	mitotic cell cycle phase transition [GO:0044772]; response to gamma radiation [GO:0010332]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	nucleus [GO:0005634]	GO:0005634; GO:0010332; GO:0016538; GO:0044772
GN016332	GN016332.1	A0A1S4GHV7	27.8	320	355	493	2.06e-28	118	FUTA_ANOGA	Core alpha-(1,3)-fucosyltransferase (EC 2.4.1.214) (Fucosyltransferase A) (AgFucTA)	Anopheles gambiae (African malaria mosquito)	N-glycan processing [GO:0006491]	glycoprotein 3-alpha-L-fucosyltransferase activity [GO:0018392]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0018392; GO:0032580
GN016333	GN016333.1	Q8IWL3	39.9	188	279	235	7.16e-32	120	HSC20_HUMAN	Iron-sulfur cluster co-chaperone protein HscB (DnaJ homolog subfamily C member 20) [Cleaved into: Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic (C-HSC20); Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]	Homo sapiens (Human)	[2Fe-2S] cluster assembly [GO:0044571]; iron-sulfur cluster assembly [GO:0016226]; primitive erythrocyte differentiation [GO:0060319]; primitive hemopoiesis [GO:0060215]; protein complex oligomerization [GO:0051259]	ATPase activator activity [GO:0001671]; identical protein binding [GO:0042802]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0001671; GO:0005737; GO:0005739; GO:0005829; GO:0016226; GO:0042802; GO:0044571; GO:0051087; GO:0051259; GO:0060215; GO:0060319
GN016334	GN016334.1	Q91XE9	57.1	154	551	479	4.07e-36	144	CR3L3_MOUSE	Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0005654; GO:0005783; GO:0005789; GO:0005829; GO:0006357; GO:0016020; GO:0034976; GO:0042802; GO:0042803; GO:0045944; GO:0046982
GN016335	GN016335.1	Q5M7P5	43.9	1103	1124	1145	8.26e-312	901	NOL6_XENTR	Nucleolar protein 6	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; tRNA export from nucleus [GO:0006409]		chromosome [GO:0005694]; CURI complex [GO:0032545]; small-subunit processome [GO:0032040]; UTP-C complex [GO:0034456]	GO:0005694; GO:0006364; GO:0006409; GO:0032040; GO:0032545; GO:0034456; GO:0042274
GN016337	GN016337.1	A0JN62	49.6	1020	1003	987	5.23e-294	845	CE120_BOVIN	Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100)	Bos taurus (Bovine)	centrosome cycle [GO:0007098]; interkinetic nuclear migration [GO:0022027]; positive regulation of centriole elongation [GO:1903724]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of cilium assembly [GO:0045724]; positive regulation of establishment of protein localization [GO:1904951]		centriole [GO:0005814]; centrosome [GO:0005813]	GO:0005813; GO:0005814; GO:0007098; GO:0010825; GO:0022027; GO:0045724; GO:1903724; GO:1904951
GN016338	GN016338.1	Q62763	71.8	351	469	448	1.78e-168	484	KC1G3_RAT	Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1)	Rattus norvegicus (Rat)	endocytosis [GO:0006897]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004674; GO:0005524; GO:0005737; GO:0005886; GO:0006468; GO:0006897; GO:0046777; GO:0090263; GO:0106310
GN016341	GN016341.1	Q29121	39.2	457	620	559	4.26e-97	311	GALT1_PIG	Polypeptide N-acetylgalactosaminyltransferase 1 (EC 2.4.1.41) (Polypeptide GalNAc transferase 1) (GalNAc-T1) (pp-GaNTase 1) (Protein-UDP acetylgalactosaminyltransferase 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 1 soluble form]	Sus scrofa (Pig)	protein O-linked glycosylation [GO:0006493]	manganese ion binding [GO:0030145]; polypeptide N-acetylgalactosaminyltransferase activity [GO:0004653]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]	GO:0004653; GO:0005576; GO:0005794; GO:0006493; GO:0030145; GO:0032580
GN016344	GN016344.1	Q6SZ65	90.6	53	116	360	5.36e-24	97.1	OTP_LYTVA	Homeobox protein orthopedia	Lytechinus variegatus (Green sea urchin) (Echinus variegatus)	neuron differentiation [GO:0030182]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	nucleus [GO:0005634]	GO:0000981; GO:0003677; GO:0005634; GO:0030182
GN016346	GN016346.1	Q7YTC2	37.3	150	145	322	2.90e-13	68.6	OTP_SACKO	Homeobox protein orthopedia	Saccoglossus kowalevskii (Acorn worm)	neuron differentiation [GO:0030182]	DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	nucleus [GO:0005634]	GO:0000981; GO:0003677; GO:0005634; GO:0030182
GN016353	GN016353.1	P16537	38.5	91	457	208	2.14e-17	84.0	SPC3_STRPU	Protein SPEC3	Strongylocentrotus purpuratus (Purple sea urchin)			cilium [GO:0005929]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005929
GN016354	GN016354.1	Q1HRV8	46.8	250	278	358	3.50e-80	249	ELVL1_AEDAE	Very long chain fatty acid elongase AAEL008004 (EC 2.3.1.199) (3-keto acyl-CoA synthase AAEL008004) (Elongation of very long chain fatty acids protein AAEL008004) (Very-long-chain 3-oxoacyl-CoA synthase AAEL008004)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761]	fatty acid elongase activity [GO:0009922]	endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0009922; GO:0019367; GO:0030148; GO:0034625; GO:0034626; GO:0042761
GN016355	GN016355.1	Q16611	33.0	100	192	211	4.11e-10	60.1	BAK_HUMAN	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)	Homo sapiens (Human)	animal organ regeneration [GO:0031100]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to mechanical stimulus [GO:0071260]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; endocrine pancreas development [GO:0031018]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of apoptotic process [GO:0043065]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; release of cytochrome c from mitochondria [GO:0001836]; response to ethanol [GO:0045471]; response to hydrogen peroxide [GO:0042542]; response to UV-C [GO:0010225]; response to xenobiotic stimulus [GO:0009410]	BH domain binding [GO:0051400]; channel activity [GO:0015267]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; porin activity [GO:0015288]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transmembrane transporter binding [GO:0044325]	BAK complex [GO:0097145]; Bcl-2 family protein complex [GO:0097136]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; pore complex [GO:0046930]	GO:0001836; GO:0005739; GO:0005741; GO:0005783; GO:0005829; GO:0006915; GO:0008285; GO:0008630; GO:0009410; GO:0010225; GO:0010248; GO:0010629; GO:0015267; GO:0015288; GO:0031018; GO:0031072; GO:0031100; GO:0031334; GO:0032469; GO:0034620; GO:0034644; GO:0042542; GO:0042802; GO:0042803; GO:0043065; GO:0043066; GO:0044325; GO:0044877; GO:0045471; GO:0045862; GO:0046902; GO:0046930; GO:0046982; GO:0051087; GO:0051400; GO:0051881; GO:0070059; GO:0071260; GO:0090200; GO:0090201; GO:0097136; GO:0097145; GO:0097190; GO:0097192; GO:0097193; GO:1901029; GO:1901030; GO:1903896
GN016358	GN016358.1	Q5ZIJ9	36.8	68	124	954	3.29e-11	62.4	MIB2_CHICK	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (RING-type E3 ubiquitin transferase MIB2)	Gallus gallus (Chicken)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN016362	GN016362.1	P42574	35.8	151	318	277	3.90e-12	68.9	CASP3_HUMAN	Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]	Homo sapiens (Human)	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; axonal fasciculation [GO:0007413]; cellular response to staurosporine [GO:0072734]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; glial cell apoptotic process [GO:0034349]; hippocampus development [GO:0021766]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to osmotic stress [GO:0008627]; keratinocyte differentiation [GO:0030216]; learning or memory [GO:0007611]; leukocyte apoptotic process [GO:0071887]; luteolysis [GO:0001554]; negative regulation of cytokine production [GO:0001818]; neuron differentiation [GO:0030182]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet formation [GO:0030220]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of macroautophagy [GO:0016241]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647]; regulation of synaptic vesicle cycle [GO:0098693]; response to amino acid [GO:0043200]; response to anesthetic [GO:0072347]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to insulin-like growth factor stimulus [GO:1990418]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to tumor necrosis factor [GO:0034612]; response to X-ray [GO:0010165]; response to xenobiotic stimulus [GO:0009410]; striated muscle cell differentiation [GO:0051146]; swimming behavior [GO:0036269]; synapse pruning [GO:0098883]	aspartic-type endopeptidase activity [GO:0004190]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; cysteine-type endopeptidase activity [GO:0004197]; death receptor binding [GO:0005123]; enzyme activator activity [GO:0008047]; peptidase activity [GO:0008233]; phospholipase A2 activator activity [GO:0016005]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	GO:0001554; GO:0001666; GO:0001818; GO:0002020; GO:0004190; GO:0004197; GO:0004861; GO:0005123; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007413; GO:0007611; GO:0008047; GO:0008233; GO:0008627; GO:0009410; GO:0009749; GO:0010165; GO:0014069; GO:0016005; GO:0016241; GO:0016485; GO:0021766; GO:0030163; GO:0030182; GO:0030216; GO:0030218; GO:0030220; GO:0031264; GO:0031647; GO:0032025; GO:0032355; GO:0032496; GO:0032880; GO:0034349; GO:0034612; GO:0035094; GO:0036269; GO:0042542; GO:0043025; GO:0043200; GO:0043525; GO:0044877; GO:0045471; GO:0048011; GO:0051146; GO:0051384; GO:0051604; GO:0070269; GO:0071887; GO:0072347; GO:0072734; GO:0097190; GO:0097193; GO:0097194; GO:0098693; GO:0098883; GO:0098978; GO:0140639; GO:1902004; GO:1990418
GN016363	GN016363.1	Q03249	63.6	338	367	379	2.09e-165	470	GALT_MOUSE	Galactose-1-phosphate uridylyltransferase (Gal-1-P uridylyltransferase) (EC 2.7.7.12) (UDP-glucose--hexose-1-phosphate uridylyltransferase)	Mus musculus (Mouse)	galactose catabolic process via UDP-galactose, Leloir pathway [GO:0033499]; galactose metabolic process [GO:0006012]; glycolytic process from galactose [GO:0061623]; UDP-alpha-D-glucose metabolic process [GO:0006011]	UDP-glucose:hexose-1-phosphate uridylyltransferase activity [GO:0008108]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]	GO:0005737; GO:0005794; GO:0006011; GO:0006012; GO:0008108; GO:0008270; GO:0033499; GO:0061623
GN016364	GN016364.1	Q6PBX9	58.1	172	212	189	3.84e-64	199	REEP5_DANRE	Receptor expression-enhancing protein 5	Danio rerio (Zebrafish) (Brachydanio rerio)	endoplasmic reticulum membrane organization [GO:0090158]		endoplasmic reticulum membrane [GO:0005789]; sarcoplasmic reticulum membrane [GO:0033017]	GO:0005789; GO:0033017; GO:0090158
GN016365	GN016365.1	Q61532	56.9	334	749	720	7.35e-117	371	MK06_MOUSE	Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3)	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; positive regulation of dendritic spine development [GO:0060999]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; septin cytoskeleton [GO:0032156]	GO:0004672; GO:0004707; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006468; GO:0019901; GO:0032156; GO:0032991; GO:0035556; GO:0046982; GO:0060999; GO:0106310
GN016366	GN016366.1	Q9JLC8	24.8	4228	4130	4582	2.10e-285	971	SACS_MOUSE	Sacsin (DnaJ homolog subfamily C member 29)	Mus musculus (Mouse)	negative regulation of inclusion body assembly [GO:0090084]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0090084
GN016368	GN016368.1	P09480	40.3	489	532	528	7.48e-109	337	ACHA2_CHICK	Neuronal acetylcholine receptor subunit alpha-2	Gallus gallus (Chicken)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098793; GO:0099171
GN016375	GN016375.1	P0AFQ9	29.5	210	835	265	3.13e-12	71.2	YCFH_ECO57	Uncharacterized metal-dependent hydrolase YcfH (EC 3.1.-.-)	Escherichia coli O157:H7		DNA nuclease activity [GO:0004536]; hydrolase activity, acting on ester bonds [GO:0016788]	cytosol [GO:0005829]	GO:0004536; GO:0005829; GO:0016788
GN016376	GN016376.1	Q9XT77	44.7	244	327	636	2.09e-52	185	SC5A6_RABIT	Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6)	Oryctolagus cuniculus (Rabbit)	biotin import across plasma membrane [GO:1905135]; biotin transport [GO:0015878]; iodide transmembrane transport [GO:1904200]; pantothenate transmembrane transport [GO:0015887]	biotin transmembrane transporter activity [GO:0015225]; iodide transmembrane transporter activity [GO:0015111]; sodium-dependent multivitamin transmembrane transporter activity [GO:0008523]; vitamin transmembrane transporter activity [GO:0090482]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0005886; GO:0008523; GO:0015111; GO:0015225; GO:0015878; GO:0015887; GO:0016324; GO:0090482; GO:1904200; GO:1905135
GN016380	GN016380.1	Q9CR78	31.3	99	152	275	4.07e-10	59.7	MSD3_MOUSE	Myb/SANT-like DNA-binding domain-containing protein 3	Mus musculus (Mouse)				
GN016386	GN016386.1	Q9VQH2	33.7	243	260	1537	4.80e-27	113	DUOX_DROME	Dual oxidase (EC 1.11.1.-) (EC 1.6.3.1)	Drosophila melanogaster (Fruit fly)	adult chitin-based cuticle development [GO:0008365]; adult chitin-containing cuticle pigmentation [GO:0048085]; cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; imaginal disc-derived wing morphogenesis [GO:0007476]; mucosal immune response [GO:0002385]; negative regulation of apoptotic process [GO:0043066]; reactive oxygen species metabolic process [GO:0072593]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; response to wounding [GO:0009611]; superoxide anion generation [GO:0042554]; wing disc development [GO:0035220]	calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; peroxidase activity [GO:0004601]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activity [GO:0106292]	endomembrane system [GO:0012505]; NADPH oxidase complex [GO:0043020]	GO:0002385; GO:0004601; GO:0005509; GO:0006952; GO:0006979; GO:0007476; GO:0008365; GO:0009611; GO:0012505; GO:0016174; GO:0016175; GO:0019221; GO:0020037; GO:0035220; GO:0042335; GO:0042554; GO:0042742; GO:0043020; GO:0043066; GO:0048085; GO:0051591; GO:0072593; GO:0106292
GN016387	GN016387.1	Q9NRD8	65.3	118	132	1548	3.06e-46	162	DUOX2_HUMAN	Dual oxidase 2 (EC 1.-.-.-) (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase p138-tox) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Thyroid oxidase 2) (p138 thyroid oxidase)	Homo sapiens (Human)	cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; hydrogen peroxide biosynthetic process [GO:0050665]; positive regulation of cell motility [GO:2000147]; positive regulation of wound healing [GO:0090303]; regulation of thyroid hormone generation [GO:2000609]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; response to virus [GO:0009615]; superoxide anion generation [GO:0042554]; thyroid hormone generation [GO:0006590]	calcium ion binding [GO:0005509]; heme binding [GO:0020037]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; peroxidase activity [GO:0004601]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]	anchoring junction [GO:0070161]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]	GO:0004601; GO:0005509; GO:0005783; GO:0005829; GO:0005886; GO:0006590; GO:0006952; GO:0006979; GO:0009615; GO:0009986; GO:0016174; GO:0016175; GO:0016324; GO:0019221; GO:0020037; GO:0031252; GO:0042335; GO:0042554; GO:0043020; GO:0045177; GO:0050665; GO:0051591; GO:0070062; GO:0070161; GO:0090303; GO:2000147; GO:2000609
GN016390	GN016390.1	B3EWZ6	31.9	357	362	7311	2.34e-38	149	MLRP2_ACRMI	MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN016391	GN016391.1	Q9FV50	62.9	116	117	350	5.42e-47	157	MAP1D_ARATH	Methionine aminopeptidase 1D, chloroplastic/mitochondrial (MAP 1D) (MetAP 1D) (EC 3.4.11.18) (Peptidase M 1D)	Arabidopsis thaliana (Mouse-ear cress)	N-terminal protein amino acid modification [GO:0031365]; proteolysis [GO:0006508]	initiator methionyl aminopeptidase activity [GO:0004239]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]	chloroplast [GO:0009507]; mitochondrion [GO:0005739]	GO:0004239; GO:0005739; GO:0006508; GO:0009507; GO:0031365; GO:0046872; GO:0070006
GN016392	GN016392.1	Q9QXT0	41.0	156	220	182	6.17e-34	122	CNPY2_MOUSE	Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein ZSIG9) (Transmembrane protein 4)	Mus musculus (Mouse)	negative regulation of gene expression [GO:0010629]; regulation of low-density lipoprotein particle clearance [GO:0010988]		endoplasmic reticulum [GO:0005783]	GO:0005783; GO:0010629; GO:0010988
GN016400	GN016400.1	Q6YHU6	34.4	221	552	1953	3.87e-25	114	THADA_HUMAN	tRNA (32-2'-O)-methyltransferase regulator THADA (Gene inducing thyroid adenomas protein) (Thyroid adenoma-associated protein)	Homo sapiens (Human)	adaptive thermogenesis [GO:1990845]; lipid homeostasis [GO:0055088]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; tRNA methylation [GO:0030488]; tRNA nucleoside ribose methylation [GO:0002128]	enzyme regulator activity [GO:0030234]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]	GO:0002128; GO:0030234; GO:0030488; GO:0032471; GO:0055088; GO:0098554; GO:1990845
GN016401	GN016401.1	Q2TBG7	59.6	104	112	152	5.71e-44	143	ISCA2_BOVIN	Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1)	Bos taurus (Bovine)	iron-sulfur cluster assembly [GO:0016226]; protein maturation [GO:0051604]	2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]	mitochondrial [4Fe-4S] assembly complex [GO:0120510]; mitochondrion [GO:0005739]	GO:0005506; GO:0005739; GO:0016226; GO:0051537; GO:0051539; GO:0051604; GO:0120510
GN016402	GN016402.1	Q3T0V9	67.4	319	319	318	1.67e-156	443	DEOC_BOVIN	Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase)	Bos taurus (Bovine)	2'-deoxyribonucleoside catabolic process [GO:0046121]; deoxyribonucleotide catabolic process [GO:0009264]; deoxyribose phosphate catabolic process [GO:0046386]	deoxyribose-phosphate aldolase activity [GO:0004139]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0004139; GO:0005654; GO:0005737; GO:0009264; GO:0046121; GO:0046386
GN016403	GN016403.1	Q16975	83.5	364	452	743	6.00e-221	628	KPC2_APLCA	Calcium-independent protein kinase C (EC 2.7.11.13) (APL II)	Aplysia californica (California sea hare)	learning or memory [GO:0007611]	ATP binding [GO:0005524]; diacylglycerol-dependent serine/threonine kinase activity [GO:0004697]; protein serine kinase activity [GO:0106310]	membrane [GO:0016020]	GO:0004697; GO:0005524; GO:0007611; GO:0016020; GO:0106310
GN016404	GN016404.1	O95198	25.4	248	334	593	3.18e-18	89.0	KLHL2_HUMAN	Kelch-like protein 2 (Actin-binding protein Mayven)	Homo sapiens (Human)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	actin binding [GO:0003779]; identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	actin cytoskeleton [GO:0015629]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; ruffle [GO:0001726]	GO:0001726; GO:0003779; GO:0005737; GO:0005829; GO:0015629; GO:0016567; GO:0030027; GO:0031463; GO:0042802; GO:0043161; GO:1990756
GN016405	GN016405.1	Q96NE9	35.7	406	956	622	4.20e-63	228	FRMD6_HUMAN	FERM domain-containing protein 6 (Willin)	Homo sapiens (Human)	positive regulation of hippo signaling [GO:0035332]	protein sequestering activity [GO:0140311]	apical junction complex [GO:0043296]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0005911; GO:0035332; GO:0043296; GO:0140311
GN016407	GN016407.1	Q6DBR9	46.2	106	228	182	3.61e-24	97.8	KXDL1_DANRE	KxDL motif-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	lysosome localization [GO:0032418]; vesicle-mediated transport [GO:0016192]		BORC complex [GO:0099078]; lysosomal membrane [GO:0005765]	GO:0005765; GO:0016192; GO:0032418; GO:0099078
GN016411	GN016411.1	Q7Z449	36.2	409	374	544	4.44e-78	253	CP2U1_HUMAN	Cytochrome P450 2U1 (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)	Homo sapiens (Human)	cytochrome metabolic process [GO:1903604]; omega-hydroxylase P450 pathway [GO:0097267]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	arachidonate omega-hydroxylase activity [GO:0052869]; fatty acid omega-1 hydroxylase activity [GO:0120502]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]	GO:0004497; GO:0005506; GO:0005737; GO:0005743; GO:0005789; GO:0006805; GO:0008202; GO:0008395; GO:0016712; GO:0020037; GO:0052869; GO:0097267; GO:0102033; GO:0120502; GO:1903604
GN016412	GN016412.1	Q8R1B8	27.5	447	496	470	5.34e-32	131	RORB_MOUSE	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)	Mus musculus (Mouse)	amacrine cell differentiation [GO:0035881]; cellular response to retinoic acid [GO:0071300]; eye photoreceptor cell development [GO:0042462]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; retinal rod cell differentiation [GO:0060221]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; melatonin receptor activity [GO:0008502]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0004879; GO:0005634; GO:0005654; GO:0006357; GO:0008270; GO:0008502; GO:0035881; GO:0042462; GO:0042752; GO:0043565; GO:0045668; GO:0045892; GO:0045893; GO:0045944; GO:0046548; GO:0046549; GO:0060041; GO:0060221; GO:0071300; GO:1990837
GN016413	GN016413.1	H2A0L1	31.1	373	657	456	2.35e-32	134	TYRO2_PINMG	Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2)	Margaritifera margaritifera (Freshwater pearl mussel)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN016414	GN016414.1	H2A0L1	31.6	358	657	456	7.90e-32	132	TYRO2_PINMG	Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2)	Margaritifera margaritifera (Freshwater pearl mussel)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN016417	GN016417.1	A6NKF2	63.9	61	207	412	1.63e-11	65.9	ARI3C_HUMAN	AT-rich interactive domain-containing protein 3C (ARID domain-containing protein 3C)	Homo sapiens (Human)	macrophage differentiation [GO:0030225]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	cytoplasm [GO:0005737]; membrane raft [GO:0045121]; nucleus [GO:0005634]	GO:0000981; GO:0003677; GO:0003682; GO:0005634; GO:0005737; GO:0006357; GO:0030225; GO:0045121
GN016418	GN016418.1	A2BEA6	61.7	149	159	570	6.30e-48	166	ARI3A_DANRE	AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (Bright homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0005737; GO:0006357
GN016424	GN016424.1	Q7Z449	39.9	381	382	544	2.75e-93	292	CP2U1_HUMAN	Cytochrome P450 2U1 (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)	Homo sapiens (Human)	cytochrome metabolic process [GO:1903604]; omega-hydroxylase P450 pathway [GO:0097267]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	arachidonate omega-hydroxylase activity [GO:0052869]; fatty acid omega-1 hydroxylase activity [GO:0120502]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]	GO:0004497; GO:0005506; GO:0005737; GO:0005743; GO:0005789; GO:0006805; GO:0008202; GO:0008395; GO:0016712; GO:0020037; GO:0052869; GO:0097267; GO:0102033; GO:0120502; GO:1903604
GN016425	GN016425.1	P10632	40.3	452	478	490	3.00e-119	361	CP2C8_HUMAN	Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase)	Homo sapiens (Human)	epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; icosanoid biosynthetic process [GO:0046456]; lipid hydroxylation [GO:0002933]; long-chain fatty acid biosynthetic process [GO:0042759]; omega-hydroxylase P450 pathway [GO:0097267]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	arachidonate 11,12-epoxygenase activity [GO:0008405]; arachidonate 14,15-epoxygenase activity [GO:0008404]; arachidonate epoxygenase activity [GO:0008392]; caffeine oxidase activity [GO:0034875]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	GO:0002933; GO:0004497; GO:0005506; GO:0005737; GO:0005789; GO:0006805; GO:0008202; GO:0008210; GO:0008392; GO:0008401; GO:0008404; GO:0008405; GO:0016712; GO:0019373; GO:0020037; GO:0034875; GO:0042178; GO:0042572; GO:0042573; GO:0042759; GO:0046456; GO:0070989; GO:0097267; GO:0101020
GN016427	GN016427.1	Q7ZXZ2	38.5	208	230	515	4.04e-41	149	UTP15_XENLA	U3 small nucleolar RNA-associated protein 15 homolog	Xenopus laevis (African clawed frog)	positive regulation of transcription by RNA polymerase I [GO:0045943]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]		small-subunit processome [GO:0032040]	GO:0006364; GO:0032040; GO:0042274; GO:0045943
GN016428	GN016428.1	Q05920	68.8	1149	1204	1178	0.0	1643	PYC_MOUSE	Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)	Mus musculus (Mouse)	branched-chain amino acid catabolic process [GO:0009083]; gluconeogenesis [GO:0006094]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; host-mediated activation of viral process [GO:0044794]; NAD+ metabolic process [GO:0019674]; NADP+ metabolic process [GO:0006739]; negative regulation of gene expression [GO:0010629]; positive regulation of phospholipid biosynthetic process [GO:0071073]; viral release from host cell [GO:0019076]; viral RNA genome packaging [GO:0019074]	ATP binding [GO:0005524]; biotin binding [GO:0009374]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; pyruvate carboxylase activity [GO:0004736]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	GO:0004736; GO:0005524; GO:0005737; GO:0005739; GO:0005743; GO:0005759; GO:0006094; GO:0006739; GO:0009083; GO:0009374; GO:0010629; GO:0019074; GO:0019076; GO:0019674; GO:0032991; GO:0042802; GO:0044794; GO:0044877; GO:0046166; GO:0046872; GO:0071073
GN016429	GN016429.1	Q8R2K4	47.6	382	808	616	7.72e-101	328	TAF6L_MOUSE	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) (PCAF-associated factor 65-alpha) (PAF65-alpha)	Mus musculus (Mouse)	positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA splicing [GO:0043484]; regulation of somatic stem cell population maintenance [GO:1904672]; RNA polymerase II preinitiation complex assembly [GO:0051123]	protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]; transcription coactivator activity [GO:0003713]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669]	GO:0000124; GO:0003713; GO:0005634; GO:0005654; GO:0005669; GO:0006282; GO:0006355; GO:0016251; GO:0043484; GO:0045893; GO:0046695; GO:0046982; GO:0051123; GO:1904672
GN016439	GN016439.1	P07686	54.5	123	128	556	1.29e-40	144	HEXB_HUMAN	Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]	Homo sapiens (Human)	astrocyte cell migration [GO:0043615]; carbohydrate metabolic process [GO:0005975]; chondroitin sulfate proteoglycan catabolic process [GO:0030207]; dermatan sulfate proteoglycan catabolic process [GO:0030209]; ganglioside catabolic process [GO:0006689]; glycosaminoglycan metabolic process [GO:0030203]; hyaluronan catabolic process [GO:0030214]; N-acetylglucosamine metabolic process [GO:0006044]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell shape [GO:0008360]; single fertilization [GO:0007338]	acetylglucosaminyltransferase activity [GO:0008375]; beta-N-acetylglucosaminidase activity [GO:0016231]; beta-N-acetylhexosaminidase activity [GO:0004563]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; beta-N-acetylhexosaminidase complex [GO:1905379]; cortical granule [GO:0060473]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; membrane [GO:0016020]	GO:0001669; GO:0004563; GO:0005576; GO:0005764; GO:0005975; GO:0006044; GO:0006689; GO:0007338; GO:0008360; GO:0008375; GO:0016020; GO:0016231; GO:0030203; GO:0030207; GO:0030209; GO:0030214; GO:0030246; GO:0035578; GO:0042582; GO:0042802; GO:0043202; GO:0043615; GO:0044877; GO:0045944; GO:0060473; GO:0070062; GO:1905379
GN016440	GN016440.1	Q9LQV2	39.6	761	1434	1107	9.01e-133	441	RDR1_ARATH	RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1)	Arabidopsis thaliana (Mouse-ear cress)	positive regulation of post-transcriptional gene silencing [GO:0060148]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; siRNA processing [GO:0030422]; wax biosynthetic process [GO:0010025]	nucleic acid binding [GO:0003676]; RNA-directed RNA polymerase activity [GO:0003968]	nuclear RNA-directed RNA polymerase complex [GO:0031380]; nucleus [GO:0005634]	GO:0003676; GO:0003968; GO:0005634; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0031380; GO:0060148
GN016441	GN016441.1	Q9LQV2	28.4	468	522	1107	4.10e-26	116	RDR1_ARATH	RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1)	Arabidopsis thaliana (Mouse-ear cress)	positive regulation of post-transcriptional gene silencing [GO:0060148]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; siRNA processing [GO:0030422]; wax biosynthetic process [GO:0010025]	nucleic acid binding [GO:0003676]; RNA-directed RNA polymerase activity [GO:0003968]	nuclear RNA-directed RNA polymerase complex [GO:0031380]; nucleus [GO:0005634]	GO:0003676; GO:0003968; GO:0005634; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0031380; GO:0060148
GN016442	GN016442.1	Q9LQV2	42.8	421	1193	1107	1.49e-87	311	RDR1_ARATH	RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1)	Arabidopsis thaliana (Mouse-ear cress)	positive regulation of post-transcriptional gene silencing [GO:0060148]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; siRNA processing [GO:0030422]; wax biosynthetic process [GO:0010025]	nucleic acid binding [GO:0003676]; RNA-directed RNA polymerase activity [GO:0003968]	nuclear RNA-directed RNA polymerase complex [GO:0031380]; nucleus [GO:0005634]	GO:0003676; GO:0003968; GO:0005634; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0031380; GO:0060148
GN016443	GN016443.1	Q9LQV2	42.3	428	1195	1107	6.10e-86	306	RDR1_ARATH	RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1)	Arabidopsis thaliana (Mouse-ear cress)	positive regulation of post-transcriptional gene silencing [GO:0060148]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; siRNA processing [GO:0030422]; wax biosynthetic process [GO:0010025]	nucleic acid binding [GO:0003676]; RNA-directed RNA polymerase activity [GO:0003968]	nuclear RNA-directed RNA polymerase complex [GO:0031380]; nucleus [GO:0005634]	GO:0003676; GO:0003968; GO:0005634; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0031380; GO:0060148
GN016444	GN016444.1	Q9LQV2	29.9	394	508	1107	4.50e-28	122	RDR1_ARATH	RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1)	Arabidopsis thaliana (Mouse-ear cress)	positive regulation of post-transcriptional gene silencing [GO:0060148]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; siRNA processing [GO:0030422]; wax biosynthetic process [GO:0010025]	nucleic acid binding [GO:0003676]; RNA-directed RNA polymerase activity [GO:0003968]	nuclear RNA-directed RNA polymerase complex [GO:0031380]; nucleus [GO:0005634]	GO:0003676; GO:0003968; GO:0005634; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0031380; GO:0060148
GN016449	GN016449.1	P49578	30.2	179	329	639	1.85e-09	62.4	ACM3_CHICK	Muscarinic acetylcholine receptor M3	Gallus gallus (Chicken)	adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smooth muscle contraction [GO:0045987]; saliva secretion [GO:0046541]	G protein-coupled acetylcholine receptor activity [GO:0016907]; G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]	GO:0004930; GO:0005886; GO:0016907; GO:0043410; GO:0045211; GO:0045987; GO:0046541; GO:0071880
GN016450	GN016450.1	Q6AYP4	44.8	145	603	525	3.09e-31	131	ZC21C_RAT	Zinc finger C2HC domain-containing protein 1C	Rattus norvegicus (Rat)				
GN016451	GN016451.1	Q02338	46.8	267	356	343	4.49e-70	225	BDH_HUMAN	D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH) (Short chain dehydrogenase/reductase family 9C member 1)	Homo sapiens (Human)	ketone biosynthetic process [GO:0042181]; ketone catabolic process [GO:0042182]	3-hydroxybutyrate dehydrogenase activity [GO:0003858]	matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003858; GO:0005739; GO:0005743; GO:0005759; GO:0042181; GO:0042182; GO:0099617
GN016452	GN016452.1	Q8BJ25	37.9	95	137	218	2.29e-12	64.7	THAP3_MOUSE	THAP domain-containing protein 3	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]			GO:0045944
GN016458	GN016458.1	A7M7C7	75.0	204	492	1008	8.47e-104	335	SKOR2_MOUSE	SKI family transcriptional corepressor 2 (Fussel-18 homolog) (LBX1 corepressor 1-like protein) (Ladybird homeobox corepressor 1-like protein) (Transcriptional corepressor Corl2)	Mus musculus (Mouse)	cell development [GO:0048468]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellum morphogenesis [GO:0021587]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cerebellar granule cell precursor proliferation [GO:0021936]; regulation of dendrite morphogenesis [GO:0048814]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone deacetylase binding [GO:0042826]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; SMAD binding [GO:0046332]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000978; GO:0000981; GO:0003682; GO:0005634; GO:0005667; GO:0005737; GO:0021587; GO:0021702; GO:0021936; GO:0030512; GO:0030514; GO:0042826; GO:0045880; GO:0046332; GO:0048468; GO:0048814; GO:1990837
GN016459	GN016459.1	Q3SZZ7	46.1	228	222	312	2.07e-63	202	FGL1_BOVIN	Fibrinogen-like protein 1	Bos taurus (Bovine)	blood coagulation [GO:0007596]; hepatocyte proliferation [GO:0072574]; negative regulation of T cell activation [GO:0050868]; regulation of immune response [GO:0050776]	receptor ligand activity [GO:0048018]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0007596; GO:0031012; GO:0048018; GO:0050776; GO:0050868; GO:0072574
GN016463	GN016463.1	A1L3F4	45.2	549	522	507	4.26e-115	352	MEX3B_XENLA	RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3)	Xenopus laevis (African clawed frog)		RNA binding [GO:0003723]	nucleus [GO:0005634]; P-body [GO:0000932]	GO:0000932; GO:0003723; GO:0005634
GN016469	GN016469.1	A0A1S4F2V5	63.6	220	268	339	4.97e-99	296	CATL_AEDAE	Cathepsin L-like peptidase (AaCatL) (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain]	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	proteolysis [GO:0006508]	cysteine-type endopeptidase activity [GO:0004197]		GO:0004197; GO:0006508
GN016470	GN016470.1	Q865K9	36.2	287	331	354	4.55e-55	186	MPRB_PIG	Membrane progestin receptor beta (mPR beta) (Progestin and adipoQ receptor family member VIII)	Sus scrofa (Pig)	response to steroid hormone [GO:0048545]	nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]	plasma membrane [GO:0005886]	GO:0003707; GO:0005496; GO:0005886; GO:0048545
GN016471	GN016471.1	Q8NEF3	41.4	444	488	446	1.16e-84	271	CC112_HUMAN	Coiled-coil domain-containing protein 112 (Mutated in bladder cancer protein 1)	Homo sapiens (Human)			centriolar satellite [GO:0034451]	GO:0034451
GN016472	GN016472.1	Q503I8	56.4	289	296	644	1.05e-114	347	NGLY1_DANRE	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase)	Danio rerio (Zebrafish) (Brachydanio rerio)	glycoprotein catabolic process [GO:0006516]; peripheral nervous system neuron axonogenesis [GO:0048936]; positive regulation of BMP signaling pathway [GO:0030513]; regulation of protein catabolic process [GO:0042176]; regulation of protein folding [GO:1903332]; skeletal muscle tissue development [GO:0007519]; swimming behavior [GO:0036269]	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [GO:0000224]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000224; GO:0005634; GO:0005737; GO:0006516; GO:0007519; GO:0030513; GO:0036269; GO:0042176; GO:0048936; GO:1903332
GN016473	GN016473.1	Q5ZJM3	50.8	185	200	651	7.48e-52	179	NGLY1_CHICK	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase)	Gallus gallus (Chicken)	glycoprotein catabolic process [GO:0006516]; positive regulation of BMP signaling pathway [GO:0030513]	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [GO:0000224]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000224; GO:0005634; GO:0005737; GO:0006516; GO:0030513
GN016475	GN016475.1	A4QNC6	36.0	136	141	138	1.62e-28	104	TIMCC_XENTR	TIM double twin CX3C motif protein	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			mitochondrial intermembrane space [GO:0005758]	GO:0005758
GN016476	GN016476.1	A7YWS7	59.0	497	645	527	7.17e-223	633	DPOE2_BOVIN	DNA polymerase epsilon subunit 2 (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B)	Bos taurus (Bovine)	DNA-templated DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276]	DNA binding [GO:0003677]	epsilon DNA polymerase complex [GO:0008622]	GO:0003677; GO:0006261; GO:0008622; GO:0042276
GN016479	GN016479.1	Q9CR78	31.9	94	97	275	1.91e-09	55.8	MSD3_MOUSE	Myb/SANT-like DNA-binding domain-containing protein 3	Mus musculus (Mouse)				
GN016480	GN016480.1	Q6AZB8	26.8	168	154	349	2.27e-13	69.3	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN016482	GN016482.1	P86789	35.8	229	488	302	1.03e-36	140	GIGA6_MAGGI	Gigasin-6	Magallana gigas (Pacific oyster) (Crassostrea gigas)			membrane [GO:0016020]	GO:0016020
GN016483	GN016483.1	Q9UGM3	27.1	1680	1853	2413	3.94e-129	454	DMBT1_HUMAN	Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Deleted in malignant brain tumors 1 protein) (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein)	Homo sapiens (Human)	defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]	calcium-dependent protein binding [GO:0048306]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]; phagocytic vesicle membrane [GO:0030670]; zymogen granule membrane [GO:0042589]	GO:0005044; GO:0005576; GO:0005737; GO:0030670; GO:0030855; GO:0031012; GO:0035375; GO:0038187; GO:0042589; GO:0043152; GO:0045087; GO:0048306; GO:0050829; GO:0050830; GO:0070062; GO:0140144
GN016485	GN016485.1	A7YWG4	45.3	296	514	318	7.49e-79	252	GGH_BOVIN	Gamma-glutamyl hydrolase (EC 3.4.19.9) (Conjugase) (GH) (Gamma-Glu-X carboxypeptidase)	Bos taurus (Bovine)		gamma-glutamyl-peptidase activity [GO:0034722]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lysosome [GO:0005764]; melanosome [GO:0042470]	GO:0005576; GO:0005764; GO:0005783; GO:0034722; GO:0042470
GN016490	GN016490.1	Q93075	31.3	163	426	761	1.15e-12	73.6	TATD2_HUMAN	3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2)	Homo sapiens (Human)		hydrolase activity, acting on ester bonds [GO:0016788]	nucleoplasm [GO:0005654]	GO:0005654; GO:0016788
GN016491	GN016491.1	Q4U2R1	43.2	81	111	4836	8.70e-12	63.5	HERC2_MOUSE	E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; negative regulation of Notch signaling pathway [GO:0045746]; neuron differentiation [GO:0030182]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]	SUMO binding [GO:0032183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005737; GO:0005743; GO:0005814; GO:0005829; GO:0005886; GO:0006974; GO:0007283; GO:0008270; GO:0016567; GO:0030182; GO:0031625; GO:0032183; GO:0043161; GO:0045746; GO:0050821; GO:0061630
GN016492	GN016492.1	Q28113	31.1	293	335	344	7.41e-30	119	FUT2_BOVIN	Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Secretor factor) (Se) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)	Bos taurus (Bovine)	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; protein O-linked glycosylation via fucose [GO:0036066]	alpha-(1,2)-fucosyltransferase activity [GO:0031127]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]	GO:0005794; GO:0005975; GO:0008107; GO:0009101; GO:0031127; GO:0032580; GO:0036066
GN016496	GN016496.1	O95714	41.3	75	201	4834	3.14e-10	62.4	HERC2_HUMAN	E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)	Homo sapiens (Human)	DNA damage response [GO:0006974]; intracellular protein transport [GO:0006886]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]	guanyl-nucleotide exchange factor activity [GO:0005085]; SUMO binding [GO:0032183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005085; GO:0005634; GO:0005654; GO:0005737; GO:0005814; GO:0005829; GO:0006886; GO:0006974; GO:0008270; GO:0016020; GO:0016567; GO:0031625; GO:0032183; GO:0043161; GO:0050821; GO:0061630
GN016498	GN016498.1	O45782	27.2	272	376	426	1.33e-15	81.3	ARD17_CAEEL	Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1)	Caenorhabditis elegans		molecular adaptor activity [GO:0060090]; protein phosphatase 2B binding [GO:0030346]	cytoplasm [GO:0005737]	GO:0005737; GO:0030346; GO:0060090
GN016499	GN016499.1	A0AVT1	52.4	1016	1018	1052	0.0	1044	UBA6_HUMAN	Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)	Homo sapiens (Human)	DNA damage response [GO:0006974]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	FAT10 activating enzyme activity [GO:0019780]; ubiquitin activating enzyme activity [GO:0004839]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004839; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006511; GO:0006974; GO:0016567; GO:0019780
GN016503	GN016503.1	Q95218	27.0	868	787	1594	1.77e-69	253	DMBT1_RABIT	Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Deleted in malignant brain tumors 1 protein) (Hensin)	Oryctolagus cuniculus (Rabbit)	cell-cell junction maintenance [GO:0045217]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]	zymogen binding [GO:0035375]	extracellular matrix [GO:0031012]; zymogen granule membrane [GO:0042589]	GO:0031012; GO:0035375; GO:0042589; GO:0045217; GO:0050829; GO:0050830
GN016504	GN016504.1	P48605	74.6	169	173	544	5.28e-83	257	TCPG_DROME	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (Chaperonin containing TCP1 subunit 3)	Drosophila melanogaster (Fruit fly)	lumen formation, open tracheal system [GO:0035149]; protein folding [GO:0006457]; terminal branching, open tracheal system [GO:0007430]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]	chaperonin-containing T-complex [GO:0005832]	GO:0005524; GO:0005832; GO:0006457; GO:0007430; GO:0016887; GO:0035149; GO:0140662
GN016505	GN016505.1	P50143	70.1	278	283	547	1.91e-138	404	TCPG_XENLA	T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma)	Xenopus laevis (African clawed frog)	protein folding [GO:0006457]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]	chaperonin-containing T-complex [GO:0005832]	GO:0005524; GO:0005832; GO:0006457; GO:0016887; GO:0140662
GN016506	GN016506.1	Q63616	48.2	623	618	617	3.36e-196	567	VP33B_RAT	Vacuolar protein sorting-associated protein 33B (r-vps33b)	Rattus norvegicus (Rat)	collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; megakaryocyte development [GO:0035855]; melanosome localization [GO:0032400]; membrane fusion [GO:0061025]; peptidyl-lysine hydroxylation [GO:0017185]; platelet alpha granule organization [GO:0070889]; protein transport [GO:0015031]; regulation of platelet aggregation [GO:0090330]; skin morphogenesis [GO:0043589]; vesicle-mediated transport [GO:0016192]	protein-containing complex binding [GO:0044877]	clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule [GO:0031091]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]	GO:0005737; GO:0005764; GO:0005765; GO:0005768; GO:0005769; GO:0005770; GO:0005794; GO:0006886; GO:0007032; GO:0008021; GO:0015031; GO:0016192; GO:0017185; GO:0030136; GO:0030199; GO:0030897; GO:0031091; GO:0031901; GO:0031902; GO:0032400; GO:0032418; GO:0032963; GO:0035855; GO:0043589; GO:0044877; GO:0048471; GO:0055037; GO:0061025; GO:0070889; GO:0090330
GN016507	GN016507.1	Q9H8W5	24.9	437	623	580	8.13e-14	78.2	TRI45_HUMAN	E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99)	Homo sapiens (Human)	negative regulation of inflammatory response [GO:0050728]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0005829; GO:0008270; GO:0043161; GO:0050728; GO:0061630; GO:0070936
GN016509	GN016509.1	V5NAL9	44.0	273	299	899	2.71e-63	217	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN016510	GN016510.1	Q13263	26.8	276	632	835	1.63e-11	71.2	TIF1B_HUMAN	Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of type I interferon production [GO:0032481]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; promoter-specific chromatin binding [GO:1990841]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000785; GO:0000791; GO:0000792; GO:0001837; GO:0003677; GO:0003682; GO:0003713; GO:0003714; GO:0003723; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0006281; GO:0006325; GO:0006346; GO:0006974; GO:0008270; GO:0016567; GO:0016925; GO:0019789; GO:0031625; GO:0032481; GO:0032991; GO:0035851; GO:0042307; GO:0043124; GO:0043161; GO:0044790; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0061630; GO:0061665; GO:0070087; GO:0090575; GO:0140374; GO:0140463; GO:1990841
GN016511	GN016511.1	V5NAL9	51.9	135	133	899	7.22e-36	133	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN016512	GN016512.1	V5NAL9	44.6	424	432	899	3.44e-96	311	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN016513	GN016513.1	Q7KVW5	61.2	464	790	927	8.87e-181	545	KCNN_DROME	Small conductance calcium-activated potassium channel protein (Protein SK) (dSK)	Drosophila melanogaster (Fruit fly)	potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential in photoreceptor cell [GO:0016057]	calmodulin binding [GO:0005516]; photoreceptor activity [GO:0009881]; small conductance calcium-activated potassium channel activity [GO:0016286]	membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	GO:0005516; GO:0005886; GO:0006813; GO:0009881; GO:0016020; GO:0016057; GO:0016286; GO:0043005; GO:0043025; GO:0071805
GN016517	GN016517.1	Q2TBE0	40.4	970	932	894	2.39e-157	488	C19L2_HUMAN	Pre-mRNA splicing factor CWF19L2 (CWF19-like protein 2)	Homo sapiens (Human)	mRNA splicing, via spliceosome [GO:0000398]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; spliceosomal complex [GO:0005681]	GO:0000398; GO:0005634; GO:0005654; GO:0005681; GO:0071014
GN016518	GN016518.1	Q9HCS2	41.2	481	473	524	9.78e-139	412	CP4FC_HUMAN	Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12)	Homo sapiens (Human)	arachidonate metabolic process [GO:0019369]; epoxygenase P450 pathway [GO:0019373]; fatty acid metabolic process [GO:0006631]; leukotriene B4 catabolic process [GO:0036101]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; phylloquinone catabolic process [GO:0042376]; pressure natriuresis [GO:0003095]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; xenobiotic metabolic process [GO:0006805]	alkane 1-monooxygenase activity [GO:0018685]; arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; leukotriene-B4 20-monooxygenase activity [GO:0050051]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	GO:0000038; GO:0001676; GO:0003091; GO:0003095; GO:0004497; GO:0005506; GO:0005737; GO:0005789; GO:0006631; GO:0006805; GO:0008392; GO:0016324; GO:0016712; GO:0018685; GO:0019369; GO:0019373; GO:0020037; GO:0036101; GO:0042360; GO:0042361; GO:0042376; GO:0043231; GO:0050051; GO:0055078
GN016519	GN016519.1	P17635	45.8	504	544	535	7.36e-155	456	FMO2_RABIT	Dimethylaniline monooxygenase [N-oxide-forming] 2 (EC 1.14.13.-) (EC 1.14.13.8) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2)	Oryctolagus cuniculus (Rabbit)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0004499; GO:0005789; GO:0016020; GO:0050660; GO:0050661
GN016520	GN016520.1	P17635	42.0	528	543	535	8.50e-137	410	FMO2_RABIT	Dimethylaniline monooxygenase [N-oxide-forming] 2 (EC 1.14.13.-) (EC 1.14.13.8) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2)	Oryctolagus cuniculus (Rabbit)		flavin adenine dinucleotide binding [GO:0050660]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0004499; GO:0005789; GO:0016020; GO:0050660; GO:0050661
GN016522	GN016522.1	Q13263	29.2	195	640	835	1.99e-10	67.8	TIF1B_HUMAN	Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; chromatin organization [GO:0006325]; DNA damage response [GO:0006974]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of type I interferon production [GO:0032481]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; promoter-specific chromatin binding [GO:1990841]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000785; GO:0000791; GO:0000792; GO:0001837; GO:0003677; GO:0003682; GO:0003713; GO:0003714; GO:0003723; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0006281; GO:0006325; GO:0006346; GO:0006974; GO:0008270; GO:0016567; GO:0016925; GO:0019789; GO:0031625; GO:0032481; GO:0032991; GO:0035851; GO:0042307; GO:0043124; GO:0043161; GO:0044790; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0061630; GO:0061665; GO:0070087; GO:0090575; GO:0140374; GO:0140463; GO:1990841
GN016524	GN016524.1	V5NAL9	44.1	424	432	899	4.17e-91	297	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN016526	GN016526.1	Q70LM4	28.0	1063	1595	5085	1.85e-95	347	LGRD_BREPA	Linear gramicidin synthase subunit D [Includes: ATP-dependent D-leucine adenylase (D-LeuA) (D-leucine activase); Leucine racemase [ATP-hydrolyzing] (EC 5.1.1.-); ATP-dependent tryptophan adenylase (TrpA) (Tryptophan activase); ATP-dependent glycine adenylase (GlyA) (Glycine activase); Linear gramicidin--PCP reductase (EC 1.-.-.-)]	Brevibacillus parabrevis	amino acid activation for nonribosomal peptide biosynthetic process [GO:0043041]; lipid biosynthetic process [GO:0008610]; monocarboxylic acid biosynthetic process [GO:0072330]; secondary metabolite biosynthetic process [GO:0044550]	catalytic activity [GO:0003824]; phosphopantetheine binding [GO:0031177]	cytosol [GO:0005829]	GO:0003824; GO:0005829; GO:0008610; GO:0031177; GO:0043041; GO:0044550; GO:0072330
GN016530	GN016530.1	Q70LM4	27.9	1063	1605	5085	1.27e-97	354	LGRD_BREPA	Linear gramicidin synthase subunit D [Includes: ATP-dependent D-leucine adenylase (D-LeuA) (D-leucine activase); Leucine racemase [ATP-hydrolyzing] (EC 5.1.1.-); ATP-dependent tryptophan adenylase (TrpA) (Tryptophan activase); ATP-dependent glycine adenylase (GlyA) (Glycine activase); Linear gramicidin--PCP reductase (EC 1.-.-.-)]	Brevibacillus parabrevis	amino acid activation for nonribosomal peptide biosynthetic process [GO:0043041]; lipid biosynthetic process [GO:0008610]; monocarboxylic acid biosynthetic process [GO:0072330]; secondary metabolite biosynthetic process [GO:0044550]	catalytic activity [GO:0003824]; phosphopantetheine binding [GO:0031177]	cytosol [GO:0005829]	GO:0003824; GO:0005829; GO:0008610; GO:0031177; GO:0043041; GO:0044550; GO:0072330
GN016533	GN016533.1	Q91YE3	26.2	271	224	400	3.64e-12	68.2	EGLN1_MOUSE	Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)	Mus musculus (Mouse)	cardiac muscle tissue morphogenesis [GO:0055008]; cellular response to hypoxia [GO:0071456]; heart trabecula formation [GO:0060347]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; labyrinthine layer development [GO:0060711]; negative regulation of CAMKK-AMPK signaling cascade [GO:1905290]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; negative regulation of hypoxia-inducible factor-1alpha signaling pathway [GO:1902072]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of neuron apoptotic process [GO:0043523]; regulation protein catabolic process at postsynapse [GO:0140252]; response to hypoxia [GO:0001666]; response to nitric oxide [GO:0071731]; ventricular septum morphogenesis [GO:0060412]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; ferrous iron binding [GO:0008198]; hypoxia-inducible factor-proline dioxygenase activity [GO:0160082]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545]; peptidyl-proline dioxygenase activity [GO:0031543]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	GO:0001666; GO:0004857; GO:0005634; GO:0005737; GO:0005829; GO:0006879; GO:0008198; GO:0014069; GO:0016706; GO:0019899; GO:0031418; GO:0031543; GO:0031545; GO:0032364; GO:0043065; GO:0043523; GO:0043525; GO:0045765; GO:0045944; GO:0051344; GO:0055008; GO:0060347; GO:0060412; GO:0060711; GO:0071456; GO:0071731; GO:0098978; GO:0099159; GO:0140252; GO:0160082; GO:1902072; GO:1905290
GN016534	GN016534.1	Q60803	38.2	537	562	567	3.33e-120	369	TRAF3_MOUSE	TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (RING-type E3 ubiquitin transferase TRAF3)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cell surface receptor signaling pathway [GO:0007166]; mRNA transcription [GO:0009299]; positive regulation of type I interferon production [GO:0032481]; regulation of apoptotic process [GO:0042981]; regulation of canonical NF-kappaB signal transduction [GO:0043122]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; signaling adaptor activity [GO:0035591]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; endosome [GO:0005768]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]	GO:0001817; GO:0002224; GO:0004842; GO:0005164; GO:0005737; GO:0005739; GO:0005768; GO:0007166; GO:0008063; GO:0008270; GO:0009299; GO:0009898; GO:0010008; GO:0019901; GO:0019903; GO:0030162; GO:0031625; GO:0031996; GO:0032481; GO:0032648; GO:0033209; GO:0034142; GO:0035591; GO:0035631; GO:0042802; GO:0042981; GO:0043122; GO:0050688; GO:0061630; GO:0140374
GN016541	GN016541.1	Q53G44	34.7	190	291	452	1.38e-22	100	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN016546	GN016546.1	O60232	41.5	193	190	199	1.70e-32	118	ZNRD2_HUMAN	Protein ZNRD2 (Autoantigen p27) (Protein zinc ribbon domain type 2) (Sjoegren syndrome/scleroderma autoantigen 1) (Zinc ribbon domain-containing protein 2)	Homo sapiens (Human)	mitotic cell cycle [GO:0000278]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]	GO:0000278; GO:0005737; GO:0042802
GN016564	GN016564.1	A0A0B4KGY6	46.6	552	574	780	1.24e-116	367	NOVA_DROME	RNA-binding protein Pasilla	Drosophila melanogaster (Fruit fly)	mRNA splicing, via spliceosome [GO:0000398]; positive regulation of RNA splicing [GO:0033120]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	pre-mRNA intronic binding [GO:0097157]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000381; GO:0000398; GO:0005634; GO:0005737; GO:0005829; GO:0033120; GO:0097157
GN016566	GN016566.1	P29275	33.8	272	410	332	1.01e-25	109	AA2BR_HUMAN	Adenosine receptor A2b	Homo sapiens (Human)	activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; vasodilation [GO:0042311]	G protein-coupled adenosine receptor activity [GO:0001609]	glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0001609; GO:0005886; GO:0007186; GO:0007189; GO:0007190; GO:0042311; GO:0098685; GO:0098793; GO:0098978; GO:0099171
GN016569	GN016569.1	O54829	58.8	434	449	469	1.70e-183	523	RGS7_MOUSE	Regulator of G protein signaling 7 (RGS7)	Mus musculus (Mouse)	G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of GTPase activity [GO:0043547]; positive regulation of potassium ion transmembrane transport [GO:1901381]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of postsynaptic membrane potential [GO:0060078]	G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; GTPase activator activity [GO:0005096]	cell tip [GO:0051286]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite terminus [GO:0044292]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]	GO:0001965; GO:0005096; GO:0005634; GO:0005635; GO:0005737; GO:0005829; GO:0005886; GO:0007186; GO:0008277; GO:0016020; GO:0030425; GO:0031681; GO:0032991; GO:0035556; GO:0042734; GO:0043005; GO:0043547; GO:0044292; GO:0045211; GO:0045744; GO:0051286; GO:0060078; GO:0098793; GO:0098978; GO:1901381
GN016570	GN016570.1	Q1RM35	39.7	141	441	350	4.98e-28	117	CFA36_DANRE	Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104)	Danio rerio (Zebrafish) (Brachydanio rerio)			axoneme [GO:0005930]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005930; GO:0031514; GO:0097546
GN016572	GN016572.1	Q9H0W7	36.7	109	362	228	9.87e-10	61.6	THAP2_HUMAN	THAP domain-containing protein 2	Homo sapiens (Human)			nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005634; GO:0005730
GN016573	GN016573.1	Q75J93	33.2	742	867	842	5.15e-125	400	CPAS1_DICDI	Circularly permutated Ras protein 1 (DdiCPRas1)	Dictyostelium discoideum (Social amoeba)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; small GTPase-mediated signal transduction [GO:0007264]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; zinc ion binding [GO:0008270]	COPII vesicle coat [GO:0030127]; plasma membrane [GO:0005886]	GO:0003924; GO:0005525; GO:0005886; GO:0006886; GO:0006888; GO:0007264; GO:0008270; GO:0030127
GN016574	GN016574.1	A0A2B4RNI3	32.7	162	667	688	8.43e-22	103	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN016578	GN016578.1	A6QQ14	55.6	81	115	116	3.43e-24	92.0	DPOE4_BOVIN	DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4)	Bos taurus (Bovine)	DNA-templated DNA replication [GO:0006261]	protein heterodimerization activity [GO:0046982]	ATAC complex [GO:0140672]; epsilon DNA polymerase complex [GO:0008622]; nucleoplasm [GO:0005654]	GO:0005654; GO:0006261; GO:0008622; GO:0046982; GO:0140672
GN016579	GN016579.1	P58283	42.6	209	868	853	2.39e-46	182	RN216_MOUSE	E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (UbcM4-interacting protein 83) (Ubiquitin-conjugating enzyme 7-interacting protein 1)	Mus musculus (Mouse)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein catabolic process, modulating synaptic transmission [GO:0099546]; protein K48-linked ubiquitination [GO:0070936]; regulation of defense response to virus by host [GO:0050691]; regulation of interferon-beta production [GO:0032648]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic endocytic zone [GO:0098843]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0008270; GO:0030136; GO:0032648; GO:0043161; GO:0050691; GO:0061630; GO:0070936; GO:0098685; GO:0098793; GO:0098843; GO:0098978; GO:0099149; GO:0099546
GN016580	GN016580.1	Q08C93	40.0	310	290	382	4.33e-79	247	ABD12_DANRE	Lysophosphatidylserine lipase ABHD12 (EC 3.1.1.-) (2-arachidonoylglycerol hydrolase ABHD12) (Abhydrolase domain-containing protein 12) (Monoacylglycerol lipase ABHD12) (EC 3.1.1.23) (Oxidized phosphatidylserine lipase ABHD12) (EC 3.1.-.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	acylglycerol catabolic process [GO:0046464]; anterior lateral line development [GO:0048899]; camera-type eye development [GO:0043010]; monoacylglycerol catabolic process [GO:0052651]; myelination [GO:0042552]; phosphatidylserine catabolic process [GO:0006660]; phospholipid catabolic process [GO:0009395]; posterior lateral line neuromast development [GO:0048919]; retina layer formation [GO:0010842]; swimming behavior [GO:0036269]	glycerophospholipase activity [GO:0004620]; monoacylglycerol lipase activity [GO:0047372]; phosphatidylinositol lysophospholipase A1 activity [GO:0120561]; phosphatidylserine lysophospholipase A1 activity [GO:0120560]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0004620; GO:0005789; GO:0006660; GO:0009395; GO:0010842; GO:0016020; GO:0036269; GO:0042552; GO:0043010; GO:0046464; GO:0047372; GO:0048899; GO:0048919; GO:0052651; GO:0120560; GO:0120561
GN016581	GN016581.1	Q8BIG4	47.4	230	382	368	3.12e-61	204	FBX28_MOUSE	F-box only protein 28	Mus musculus (Mouse)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]	identical protein binding [GO:0042802]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000209; GO:0000776; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0042802; GO:0043161; GO:1990756
GN016582	GN016582.1	A5PK63	81.3	134	135	135	3.03e-67	202	RS17_BOVIN	Small ribosomal subunit protein eS17 (40S ribosomal protein S17)	Bos taurus (Bovine)	ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic small ribosomal subunit [GO:0022627]; small-subunit processome [GO:0032040]	GO:0003735; GO:0005737; GO:0006412; GO:0022627; GO:0032040; GO:0042274
GN016583	GN016583.1	Q7ZYG4	62.6	107	215	214	2.58e-42	145	OSTF1_XENLA	Osteoclast-stimulating factor 1	Xenopus laevis (African clawed frog)	signal transduction [GO:0007165]		cytoplasm [GO:0005737]	GO:0005737; GO:0007165
GN016584	GN016584.1	Q9WVK4	59.7	216	219	534	8.95e-86	266	EHD1_MOUSE	EH domain-containing protein 1 (PAST homolog 1) (mPAST1)	Mus musculus (Mouse)	cellular response to nerve growth factor stimulus [GO:1990090]; cholesterol homeostasis [GO:0042632]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; low-density lipoprotein particle clearance [GO:0034383]; neuron projection development [GO:0031175]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of neuron projection development [GO:0010976]; protein homooligomerization [GO:0051260]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]	calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]	ciliary pocket membrane [GO:0020018]; ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; myelin sheath [GO:0043209]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; presynaptic active zone [GO:0048786]; recycling endosome membrane [GO:0055038]	GO:0005509; GO:0005525; GO:0005768; GO:0005769; GO:0005811; GO:0005886; GO:0005929; GO:0006886; GO:0006897; GO:0010008; GO:0010886; GO:0010976; GO:0016197; GO:0020018; GO:0030139; GO:0030674; GO:0031095; GO:0031175; GO:0031267; GO:0031410; GO:0031901; GO:0032456; GO:0034383; GO:0035869; GO:0042632; GO:0042802; GO:0043209; GO:0048471; GO:0048786; GO:0051260; GO:0055038; GO:0060271; GO:0061512; GO:0072659; GO:0098978; GO:1901741; GO:1990090; GO:2001137
GN016585	GN016585.1	Q3ZBE7	88.3	120	120	121	5.87e-74	218	YPEL5_BOVIN	Protein yippee-like 5	Bos taurus (Bovine)	cell population proliferation [GO:0008283]		centrosome [GO:0005813]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005634; GO:0005813; GO:0008283; GO:0030496; GO:0097431
GN016587	GN016587.1	Q9U943	28.3	290	4097	3380	2.00e-22	111	APLP_LOCMI	Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)]	Locusta migratoria (Migratory locust)	lipid transport [GO:0006869]	lipid carrier activity [GO:0005319]	extracellular region [GO:0005576]	GO:0005319; GO:0005576; GO:0006869
GN016588	GN016588.1	Q9U943	28.6	290	4097	3380	5.22e-23	113	APLP_LOCMI	Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)]	Locusta migratoria (Migratory locust)	lipid transport [GO:0006869]	lipid carrier activity [GO:0005319]	extracellular region [GO:0005576]	GO:0005319; GO:0005576; GO:0006869
GN016589	GN016589.1	Q9U943	29.3	1138	1289	3380	4.59e-116	405	APLP_LOCMI	Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)]	Locusta migratoria (Migratory locust)	lipid transport [GO:0006869]	lipid carrier activity [GO:0005319]	extracellular region [GO:0005576]	GO:0005319; GO:0005576; GO:0006869
GN016590	GN016590.1	Q9U943	29.4	1138	5435	3380	1.45e-111	406	APLP_LOCMI	Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)]	Locusta migratoria (Migratory locust)	lipid transport [GO:0006869]	lipid carrier activity [GO:0005319]	extracellular region [GO:0005576]	GO:0005319; GO:0005576; GO:0006869
GN016591	GN016591.1	Q9U943	29.3	1138	5435	3380	2.88e-112	408	APLP_LOCMI	Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)]	Locusta migratoria (Migratory locust)	lipid transport [GO:0006869]	lipid carrier activity [GO:0005319]	extracellular region [GO:0005576]	GO:0005319; GO:0005576; GO:0006869
GN016592	GN016592.1	Q9U943	29.2	1142	5435	3380	3.24e-111	405	APLP_LOCMI	Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)]	Locusta migratoria (Migratory locust)	lipid transport [GO:0006869]	lipid carrier activity [GO:0005319]	extracellular region [GO:0005576]	GO:0005319; GO:0005576; GO:0006869
GN016595	GN016595.1	P18503	27.0	174	189	366	3.97e-10	61.2	CAS4_EPHMU	Short-chain collagen C4	Ephydatia muelleri (Mueller's freshwater sponge) (Spongilla muelleri)			extracellular matrix [GO:0031012]	GO:0031012
GN016598	GN016598.1	P48601	91.8	415	449	439	2.19e-273	749	PRS4_DROME	26S proteasome regulatory subunit 4 (P26s4)	Drosophila melanogaster (Fruit fly)	proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, base subcomplex [GO:0008540]	GO:0000502; GO:0005524; GO:0005654; GO:0005829; GO:0005838; GO:0008540; GO:0010498; GO:0016887; GO:0036402; GO:0043161
GN016607	GN016607.1	O08699	41.2	245	251	266	4.34e-60	193	PGDH_RAT	15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Eicosanoid/docosanoid dehydrogenase [NAD(+)]) (EC 1.1.1.-, EC 1.1.1.232) (Prostaglandin dehydrogenase 1)	Rattus norvegicus (Rat)	ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; kidney development [GO:0001822]; lipoxin biosynthetic process [GO:2001301]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; positive regulation of apoptotic process [GO:0043065]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; prostaglandin catabolic process [GO:1905344]; prostaglandin metabolic process [GO:0006693]; regulation of prostaglandin catabolic process [GO:1905828]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; thrombin-activated receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179]	15-hydroxyicosatetraenoate dehydrogenase activity [GO:0047034]; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity [GO:0016404]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin E receptor activity [GO:0004957]	basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]	GO:0001822; GO:0004957; GO:0005576; GO:0005737; GO:0005829; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016323; GO:0016404; GO:0016616; GO:0030728; GO:0032355; GO:0032496; GO:0042802; GO:0043065; GO:0045471; GO:0045786; GO:0047034; GO:0051287; GO:0070403; GO:0070493; GO:0097070; GO:1904707; GO:1905344; GO:1905828; GO:2001301
GN016608	GN016608.1	Q9VUL9	44.4	358	489	503	2.15e-91	290	FUTA_DROME	Core alpha-(1,3)-fucosyltransferase (EC 2.4.1.214) (Alpha(1,3)-fucosyltransferase A) (Glycoprotein 3-alpha-L-fucosyltransferase FucTA)	Drosophila melanogaster (Fruit fly)	Golgi apparatus N-glycan diversification [GO:0016258]; nervous system development [GO:0007399]; protein N-linked glycosylation [GO:0006487]	alpha-(1->3)-fucosyltransferase activity [GO:0046920]; glycoprotein 3-alpha-L-fucosyltransferase activity [GO:0018392]	Golgi cisterna membrane [GO:0032580]; Golgi medial cisterna [GO:0005797]	GO:0005797; GO:0006487; GO:0007399; GO:0016258; GO:0018392; GO:0032580; GO:0046920
GN016611	GN016611.1	Q99N27	51.7	408	515	522	1.63e-131	395	SNX1_RAT	Sorting nexin-1	Rattus norvegicus (Rat)	early endosome to Golgi transport [GO:0034498]; endosomal transport [GO:0016197]; endosome membrane tubulation [GO:0097750]; intracellular protein transport [GO:0006886]; lamellipodium morphogenesis [GO:0072673]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron projection development [GO:0031175]; positive regulation of protein catabolic process [GO:0045732]; receptor internalization [GO:0031623]; retrograde transport, endosome to Golgi [GO:0042147]	epidermal growth factor receptor binding [GO:0005154]; identical protein binding [GO:0042802]; insulin receptor binding [GO:0005158]; leptin receptor binding [GO:1990460]; phosphatidylinositol binding [GO:0035091]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transferrin receptor binding [GO:1990459]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extrinsic component of postsynaptic endosome membrane [GO:0098999]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; lysosome [GO:0005764]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; vesicle [GO:0031982]	GO:0005154; GO:0005158; GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005794; GO:0005829; GO:0006886; GO:0010008; GO:0014069; GO:0016020; GO:0016197; GO:0030027; GO:0030512; GO:0030904; GO:0030905; GO:0031175; GO:0031623; GO:0031901; GO:0031982; GO:0032991; GO:0034498; GO:0035091; GO:0042147; GO:0042802; GO:0042803; GO:0043197; GO:0045732; GO:0046982; GO:0048471; GO:0072673; GO:0097750; GO:0098793; GO:0098999; GO:0099092; GO:1990459; GO:1990460
GN016612	GN016612.1	Q6GQG3	54.7	95	132	117	9.49e-21	84.0	AR19B_XENLA	cAMP-regulated phosphoprotein 19-B (ARPP-19-B)	Xenopus laevis (African clawed frog)	G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]	phosphatase inhibitor activity [GO:0019212]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]	cytoplasm [GO:0005737]	GO:0000086; GO:0000278; GO:0004864; GO:0005737; GO:0019212; GO:0019888; GO:0051721
GN016613	GN016613.1	Q9UMX0	54.0	574	565	589	7.17e-123	377	UBQL1_HUMAN	Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)	Homo sapiens (Human)	aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; cellular response to hypoxia [GO:0071456]; ERAD pathway [GO:0036503]; macroautophagy [GO:0016236]; negative regulation of store-operated calcium channel activity [GO:1901340]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of protein ubiquitination [GO:0031398]; regulation of macroautophagy [GO:0016241]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; regulation of protein ubiquitination [GO:0031396]; response to endoplasmic reticulum stress [GO:0034976]; ubiquitin-dependent protein catabolic process [GO:0006511]	identical protein binding [GO:0042802]; kinase binding [GO:0019900]; polyubiquitin modification-dependent protein binding [GO:0031593]	aggresome [GO:0016235]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GO:0000045; GO:0005654; GO:0005737; GO:0005776; GO:0005783; GO:0005829; GO:0005886; GO:0006511; GO:0016235; GO:0016236; GO:0016241; GO:0019900; GO:0031396; GO:0031398; GO:0031593; GO:0032991; GO:0034140; GO:0034976; GO:0035973; GO:0036503; GO:0042802; GO:0048471; GO:0071456; GO:0097352; GO:1901340; GO:1902175; GO:1904294
GN016615	GN016615.1	Q19673	34.3	280	637	693	5.20e-29	126	TYR3_CAEEL	Putative tyrosinase-like protein tyr-3	Caenorhabditis elegans		tyrosinase activity [GO:0004503]		GO:0004503
GN016619	GN016619.1	Q8SWR3	28.8	319	381	435	1.06e-37	144	SPR_DROME	Sex peptide receptor	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of egg-laying behavior [GO:0046662]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008528; GO:0045434; GO:0046662
GN016622	GN016622.1	O45782	27.6	308	416	426	2.13e-21	99.0	ARD17_CAEEL	Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1)	Caenorhabditis elegans		molecular adaptor activity [GO:0060090]; protein phosphatase 2B binding [GO:0030346]	cytoplasm [GO:0005737]	GO:0005737; GO:0030346; GO:0060090
GN016623	GN016623.1	Q12908	36.4	264	369	348	5.35e-47	166	NTCP2_HUMAN	Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2)	Homo sapiens (Human)	bile acid and bile salt transport [GO:0015721]	bile acid:sodium symporter activity [GO:0008508]	apical plasma membrane [GO:0016324]; microvillus [GO:0005902]; plasma membrane [GO:0005886]	GO:0005886; GO:0005902; GO:0008508; GO:0015721; GO:0016324
GN016624	GN016624.1	Q3KNW5	40.6	96	141	377	1.94e-19	85.9	SOAT_HUMAN	Sodium-dependent organic anion transporter (SOAT) (Solute carrier family 10 member 6) (SLC10A6)	Homo sapiens (Human)	bile acid and bile salt transport [GO:0015721]; sodium-dependent organic anion transport [GO:0043251]	bile acid:sodium symporter activity [GO:0008508]	plasma membrane [GO:0005886]	GO:0005886; GO:0008508; GO:0015721; GO:0043251
GN016626	GN016626.1	Q7TN88	24.0	1171	1556	2461	3.46e-76	285	PK1L2_MOUSE	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Mus musculus (Mouse)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]	membrane [GO:0016020]	GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN016628	GN016628.1	P10394	27.9	129	174	1237	4.41e-13	69.7	POL4_DROME	Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease]	Drosophila melanogaster (Fruit fly)	DNA integration [GO:0015074]; DNA repair [GO:0006281]; proteolysis [GO:0006508]	aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]; RNA-directed DNA polymerase activity [GO:0003964]	DNA polymerase complex [GO:0042575]	GO:0003676; GO:0003964; GO:0004190; GO:0006281; GO:0006508; GO:0015074; GO:0042575
GN016630	GN016630.1	A0A2B4RNI3	33.3	168	668	688	2.60e-21	102	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN016631	GN016631.1	A0A2B4RNI3	34.0	162	843	688	1.09e-21	104	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN016632	GN016632.1	A0A2B4RNI3	32.7	162	662	688	5.55e-20	98.2	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN016634	GN016634.1	Q8ND71	26.8	205	234	665	1.89e-11	66.6	GIMA8_HUMAN	GTPase IMAP family member 8 (Immune-associated nucleotide-binding protein 9) (IAN-9) (Protein IanT)	Homo sapiens (Human)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]	GO:0003924; GO:0005525; GO:0005739; GO:0005783; GO:0005794; GO:0005829
GN016636	GN016636.1	Q5UPX0	33.8	136	302	548	1.55e-16	83.2	YR290_MIMIV	Putative ATP-dependent RNA helicase R290 (EC 3.6.4.13)	Acanthamoeba polyphaga mimivirus (APMV)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]		GO:0003676; GO:0003724; GO:0005524; GO:0006260; GO:0006281; GO:0006310; GO:0016887; GO:0043138
GN016637	GN016637.1	O81025	36.2	188	270	463	4.41e-25	106	IAN10_ARATH	Immune-associated nucleotide-binding protein 10 (AtIAN10) (AIG1-like protein) (Putative protein PHLOEM PROTEIN 2-LIKE A3) (AtPP2-A3)	Arabidopsis thaliana (Mouse-ear cress)		carbohydrate binding [GO:0030246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	chloroplast [GO:0009507]; mitochondrion [GO:0005739]	GO:0003924; GO:0005525; GO:0005739; GO:0009507; GO:0030246
GN016638	GN016638.1	Q8K3K9	32.7	214	290	310	2.89e-26	108	GIMA4_RAT	GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4)	Rattus norvegicus (Rat)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]	GO:0003924; GO:0005525; GO:0005829
GN016645	GN016645.1	Q2VL54	67.3	226	272	341	6.78e-88	268	PAX9_PERPO	Paired box protein Pax-9	Perodicticus potto edwarsi (Potto)		DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634
GN016646	GN016646.1	O81025	36.2	188	270	463	4.41e-25	106	IAN10_ARATH	Immune-associated nucleotide-binding protein 10 (AtIAN10) (AIG1-like protein) (Putative protein PHLOEM PROTEIN 2-LIKE A3) (AtPP2-A3)	Arabidopsis thaliana (Mouse-ear cress)		carbohydrate binding [GO:0030246]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	chloroplast [GO:0009507]; mitochondrion [GO:0005739]	GO:0003924; GO:0005525; GO:0005739; GO:0009507; GO:0030246
GN016647	GN016647.1	Q6NW40	38.6	334	458	437	4.94e-66	221	RGMB_HUMAN	Repulsive guidance molecule B (DRG11-responsive axonal guidance and outgrowth of neurite) (DRAGON)	Homo sapiens (Human)	BMP signaling pathway [GO:0030509]; cell adhesion [GO:0007155]; positive regulation of DNA-templated transcription [GO:0045893]; signal transduction [GO:0007165]	coreceptor activity [GO:0015026]; identical protein binding [GO:0042802]	endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0005793; GO:0005886; GO:0007155; GO:0007165; GO:0015026; GO:0030509; GO:0042802; GO:0045121; GO:0045893
GN016649	GN016649.1	A0A974E306	38.0	498	510	516	2.77e-61	212	CFA53_XENLA	Cilia- and flagella-associated protein 53 (Coiled-coil domain-containing protein 11) (xCcdc11)	Xenopus laevis (African clawed frog)	cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]		axoneme [GO:0005930]; centriolar satellite [GO:0034451]	GO:0003341; GO:0005930; GO:0007368; GO:0034451
GN016650	GN016650.1	B0BM28	36.6	227	275	252	7.96e-39	139	SKA1_XENTR	SKA complex subunit 1 (Spindle and kinetochore-associated protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; regulation of microtubule polymerization or depolymerization [GO:0031110]	microtubule binding [GO:0008017]	meiotic spindle [GO:0072687]; outer kinetochore [GO:0000940]	GO:0000070; GO:0000278; GO:0000940; GO:0007080; GO:0008017; GO:0031110; GO:0051301; GO:0051315; GO:0072687
GN016653	GN016653.1	B0BM28	37.1	229	275	252	5.66e-39	139	SKA1_XENTR	SKA complex subunit 1 (Spindle and kinetochore-associated protein 1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; regulation of microtubule polymerization or depolymerization [GO:0031110]	microtubule binding [GO:0008017]	meiotic spindle [GO:0072687]; outer kinetochore [GO:0000940]	GO:0000070; GO:0000278; GO:0000940; GO:0007080; GO:0008017; GO:0031110; GO:0051301; GO:0051315; GO:0072687
GN016654	GN016654.1	A0A974E306	38.0	498	510	516	2.77e-61	212	CFA53_XENLA	Cilia- and flagella-associated protein 53 (Coiled-coil domain-containing protein 11) (xCcdc11)	Xenopus laevis (African clawed frog)	cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]		axoneme [GO:0005930]; centriolar satellite [GO:0034451]	GO:0003341; GO:0005930; GO:0007368; GO:0034451
GN016655	GN016655.1	Q9ESW8	49.7	193	197	209	2.57e-65	202	PGPI_MOUSE	Pyroglutamyl-peptidase 1 (EC 3.4.19.3) (5-oxoprolyl-peptidase) (Pyroglutamyl aminopeptidase I) (PAP-I) (Pyroglutamyl-peptidase I) (PGP-I) (Pyrrolidone-carboxylate peptidase)	Mus musculus (Mouse)	protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	peptidase activity [GO:0008233]; pyroglutamyl-peptidase activity [GO:0016920]	cytosol [GO:0005829]	GO:0005829; GO:0006508; GO:0008233; GO:0016920; GO:0030163
GN016658	GN016658.1	A5PJA1	68.3	164	180	172	2.79e-85	251	KAD6_BOVIN	Adenylate kinase isoenzyme 6 (AK6) (EC 2.7.4.3) (Coilin-interacting nuclear ATPase protein) (Dual activity adenylate kinase/ATPase) (AK/ATPase)	Bos taurus (Bovine)	ribosomal small subunit biogenesis [GO:0042274]	AMP kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0004017; GO:0005524; GO:0005654; GO:0005737; GO:0015030; GO:0016887; GO:0042274
GN016659	GN016659.1	Q5U2Q4	45.3	307	324	322	2.90e-80	249	PAR16_RAT	Protein mono-ADP-ribosyltransferase PARP16 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 15) (Poly [ADP-ribose] polymerase 16) (PARP-16)	Rattus norvegicus (Rat)	cellular response to leukemia inhibitory factor [GO:1990830]; endoplasmic reticulum unfolded protein response [GO:0030968]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of cytoplasmic translation [GO:2000766]; protein auto-ADP-ribosylation [GO:0070213]	kinase binding [GO:0019900]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]; protein serine/threonine kinase activator activity [GO:0043539]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; nuclear envelope [GO:0005635]	GO:0003950; GO:0005635; GO:0005783; GO:0005789; GO:0016020; GO:0019900; GO:0030968; GO:0036498; GO:0043539; GO:0070213; GO:0071782; GO:0140804; GO:0140806; GO:0140807; GO:1990404; GO:1990830; GO:2000766
GN016660	GN016660.1	Q8BW86	32.0	150	785	850	2.80e-10	67.8	ARG33_MOUSE	Rho guanine nucleotide exchange factor 33	Mus musculus (Mouse)		guanyl-nucleotide exchange factor activity [GO:0005085]		GO:0005085
GN016661	GN016661.1	Q5U2Q4	44.7	313	324	322	2.90e-80	249	PAR16_RAT	Protein mono-ADP-ribosyltransferase PARP16 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 15) (Poly [ADP-ribose] polymerase 16) (PARP-16)	Rattus norvegicus (Rat)	cellular response to leukemia inhibitory factor [GO:1990830]; endoplasmic reticulum unfolded protein response [GO:0030968]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of cytoplasmic translation [GO:2000766]; protein auto-ADP-ribosylation [GO:0070213]	kinase binding [GO:0019900]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]; protein serine/threonine kinase activator activity [GO:0043539]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; membrane [GO:0016020]; nuclear envelope [GO:0005635]	GO:0003950; GO:0005635; GO:0005783; GO:0005789; GO:0016020; GO:0019900; GO:0030968; GO:0036498; GO:0043539; GO:0070213; GO:0071782; GO:0140804; GO:0140806; GO:0140807; GO:1990404; GO:1990830; GO:2000766
GN016662	GN016662.1	Q9H8V3	28.1	192	1141	914	5.28e-15	84.0	ECT2_HUMAN	Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)	Homo sapiens (Human)	activation of GTPase activity [GO:0090630]; activation of protein kinase activity [GO:0032147]; bicellular tight junction assembly [GO:0070830]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to ionizing radiation [GO:0071479]; intracellular signal transduction [GO:0035556]; mitotic cytokinesis [GO:0000281]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokinesis [GO:0032467]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitotic cytokinetic process [GO:1903438]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein import into nucleus [GO:0042307]; protein homooligomerization [GO:0051260]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of cytokinesis, actomyosin contractile ring assembly [GO:2000431]; regulation of protein kinase activity [GO:0045859]; regulation of small GTPase mediated signal transduction [GO:0051056]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]	anchoring junction [GO:0070161]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cell-cell junction [GO:0005911]; centralspindlin complex [GO:0097149]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000281; GO:0005085; GO:0005096; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005911; GO:0005923; GO:0005938; GO:0007399; GO:0030496; GO:0031267; GO:0032147; GO:0032154; GO:0032467; GO:0035556; GO:0042307; GO:0042803; GO:0043065; GO:0043123; GO:0043547; GO:0045666; GO:0045859; GO:0051056; GO:0051260; GO:0051988; GO:0070161; GO:0070301; GO:0070830; GO:0071277; GO:0071479; GO:0072686; GO:0090630; GO:0097149; GO:1903438; GO:2000431
GN016663	GN016663.1	Q9NUW8	54.9	455	671	608	5.97e-182	533	TYDP1_HUMAN	Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-)	Homo sapiens (Human)	DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; regulation of DNA repair [GO:0006282]; single strand break repair [GO:0000012]	3'-tyrosyl-DNA phosphodiesterase activity [GO:0017005]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]; DNA ligase III-XRCC1 complex [GO:0070421]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0000012; GO:0003690; GO:0003697; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0006282; GO:0006302; GO:0017005; GO:0070421; GO:0090734
GN016664	GN016664.1	Q6DGZ1	70.1	174	175	175	1.89e-103	297	B9D2_DANRE	B9 domain-containing protein 2	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; establishment of planar polarity [GO:0001736]; establishment or maintenance of cell polarity [GO:0007163]; opsin transport [GO:0036372]	gamma-tubulin binding [GO:0043015]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; MKS complex [GO:0036038]	GO:0001736; GO:0005813; GO:0005929; GO:0005930; GO:0007163; GO:0036038; GO:0036064; GO:0036372; GO:0043015; GO:0060271
GN016665	GN016665.1	Q08BY0	50.0	338	360	422	4.86e-118	351	NDUF7_DANRE	Protein arginine methyltransferase NDUFAF7, mitochondrial (EC 2.1.1.320) (NADH dehydrogenase [ubiquinone] complex I, assembly factor 7) (Protein midA homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	chordate embryonic development [GO:0043009]; mitochondrial respiratory chain complex I assembly [GO:0032981]; peptidyl-arginine methylation, to symmetrical-dimethyl arginine [GO:0019918]	protein-arginine omega-N symmetric methyltransferase activity [GO:0035243]	mitochondrion [GO:0005739]	GO:0005739; GO:0019918; GO:0032981; GO:0035243; GO:0043009
GN016666	GN016666.1	Q8R2E9	53.3	437	458	467	3.73e-162	469	ERO1B_MOUSE	ERO1-like protein beta (ERO1-L-beta) (EC 1.8.3.2) (Endoplasmic reticulum oxidoreductase beta) (Endoplasmic reticulum oxidoreductin-1-like protein B) (Oxidoreductin-1-L-beta)	Mus musculus (Mouse)	cell redox homeostasis [GO:0045454]; extracellular matrix organization [GO:0030198]; glucose homeostasis [GO:0042593]; insulin processing [GO:0030070]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; protein folding in endoplasmic reticulum [GO:0034975]; protein maturation [GO:0051604]	disulfide oxidoreductase activity [GO:0015036]; FAD binding [GO:0071949]; flavin-dependent sulfhydryl oxidase activity [GO:0016971]; protein-disulfide reductase activity [GO:0015035]; thiol oxidase activity [GO:0016972]	endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0005788; GO:0005789; GO:0015035; GO:0015036; GO:0016020; GO:0016971; GO:0016972; GO:0018401; GO:0030070; GO:0030198; GO:0034975; GO:0042593; GO:0045454; GO:0051604; GO:0071949
GN016668	GN016668.1	Q62318	26.1	360	676	834	6.67e-19	95.1	TIF1B_MOUSE	Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-A-interacting protein) (KRIP-1) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; chromatin organization [GO:0006325]; convergent extension involved in axis elongation [GO:0060028]; DNA damage response [GO:0006974]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epigenetic programming of gene expression [GO:0043045]; epithelial to mesenchymal transition [GO:0001837]; genomic imprinting [GO:0071514]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of type I interferon production [GO:0032481]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; promoter-specific chromatin binding [GO:1990841]; protein kinase activity [GO:0004672]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0001701; GO:0001837; GO:0003677; GO:0003682; GO:0003713; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0006281; GO:0006325; GO:0006346; GO:0006468; GO:0006974; GO:0007566; GO:0008270; GO:0016567; GO:0016925; GO:0019789; GO:0031625; GO:0032481; GO:0032991; GO:0035851; GO:0042307; GO:0043045; GO:0043124; GO:0043161; GO:0044790; GO:0045087; GO:0045739; GO:0045869; GO:0045892; GO:0045893; GO:0046777; GO:0060028; GO:0060669; GO:0061630; GO:0061665; GO:0070087; GO:0071514; GO:0090575; GO:0140374; GO:0140463; GO:1990841
GN016669	GN016669.1	Q0V989	41.9	370	651	391	2.76e-56	199	CC85C_XENTR	Coiled-coil domain-containing protein 85C	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			adherens junction [GO:0005912]; apical junction complex [GO:0043296]; bicellular tight junction [GO:0005923]	GO:0005912; GO:0005923; GO:0043296
GN016678	GN016678.1	Q8NCA5	47.4	333	499	518	1.74e-82	268	FA98A_HUMAN	Protein FAM98A	Homo sapiens (Human)	lysosome localization [GO:0032418]; positive regulation of ruffle assembly [GO:1900029]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	protein methyltransferase activity [GO:0008276]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669]	GO:0003723; GO:0005634; GO:0005737; GO:0006388; GO:0008276; GO:0032418; GO:0072669; GO:1900029
GN016679	GN016679.1	Q5RE15	62.8	282	329	289	9.22e-121	352	PSMD8_PONAB	26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteolysis [GO:0006508]		cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome regulatory particle, lid subcomplex [GO:0008541]	GO:0005634; GO:0005829; GO:0006508; GO:0008541; GO:0022624; GO:0043161
GN016681	GN016681.1	Q6PCG7	40.6	682	587	690	3.53e-128	394	I2BLB_XENLA	Interferon regulatory factor 2-binding protein-like B (Enhanced at puberty protein 1 homolog B)	Xenopus laevis (African clawed frog)	regulation of transcription by RNA polymerase II [GO:0006357]	transcription corepressor activity [GO:0003714]	nucleus [GO:0005634]	GO:0003714; GO:0005634; GO:0006357
GN016682	GN016682.1	Q99NB1	62.3	565	583	682	4.20e-264	741	ACS2L_MOUSE	Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1) (Propionate--CoA ligase) (EC 6.2.1.17)	Mus musculus (Mouse)	acetate biosynthetic process [GO:0019413]; acetyl-CoA biosynthetic process [GO:0006085]; ethanol catabolic process [GO:0006068]; propionate biosynthetic process [GO:0019542]	acetyl-CoA synthetase activity [GO:0003987]; AMP binding [GO:0016208]; propionate-CoA ligase activity [GO:0050218]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003987; GO:0005739; GO:0005759; GO:0006068; GO:0006085; GO:0016208; GO:0019413; GO:0019542; GO:0050218
GN016684	GN016684.1	Q7ZT47	56.4	195	191	196	1.48e-74	225	PSF1_XENLA	DNA replication complex GINS protein PSF1 (GINS complex subunit 1)	Xenopus laevis (African clawed frog)	DNA replication [GO:0006260]; DNA strand elongation involved in mitotic DNA replication [GO:1902983]	chromatin binding [GO:0003682]	chromosome [GO:0005694]; CMG complex [GO:0071162]; GINS complex [GO:0000811]; nucleus [GO:0005634]	GO:0000811; GO:0003682; GO:0005634; GO:0005694; GO:0006260; GO:0071162; GO:1902983
GN016685	GN016685.1	Q04861	32.7	226	368	983	1.22e-26	115	NFKB1_CHICK	Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]	Gallus gallus (Chicken)	canonical NF-kappaB signal transduction [GO:0007249]; positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; NF-kappaB binding [GO:0051059]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; NF-kappaB p50/p65 complex [GO:0035525]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0005737; GO:0007249; GO:0035525; GO:0045944; GO:0051059
GN016689	GN016689.1	Q9P2K2	25.1	758	935	825	1.64e-56	213	TXD16_HUMAN	Thioredoxin domain-containing protein 16	Homo sapiens (Human)			endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	GO:0005576; GO:0005788; GO:0070062
GN016691	GN016691.1	Q9FN03	28.3	293	961	440	7.72e-29	124	UVR8_ARATH	Ultraviolet-B receptor UVR8 (Protein UV-B RESISTANCE 8) (RCC1 domain-containing protein UVR8)	Arabidopsis thaliana (Mouse-ear cress)	entrainment of circadian clock [GO:0009649]; response to UV [GO:0009411]; response to UV-B [GO:0010224]	chromatin binding [GO:0003682]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plastid [GO:0009536]	GO:0000785; GO:0003682; GO:0005085; GO:0005634; GO:0005737; GO:0005829; GO:0009411; GO:0009536; GO:0009649; GO:0010224; GO:0042802; GO:0042803
GN016693	GN016693.1	O05465	34.9	106	450	401	6.68e-09	61.2	AMPC_PSYIM	Beta-lactamase (EC 3.5.2.6) (Cephalosporinase)	Psychrobacter immobilis	antibiotic catabolic process [GO:0017001]	beta-lactamase activity [GO:0008800]	outer membrane-bounded periplasmic space [GO:0030288]	GO:0008800; GO:0017001; GO:0030288
GN016694	GN016694.1	P86789	33.0	279	527	302	6.28e-35	136	GIGA6_MAGGI	Gigasin-6	Magallana gigas (Pacific oyster) (Crassostrea gigas)			membrane [GO:0016020]	GO:0016020
GN016695	GN016695.1	Q91YD4	45.7	81	114	1506	9.54e-17	77.8	TRPM2_MOUSE	Transient receptor potential cation channel subfamily M member 2 (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7)	Mus musculus (Mouse)	calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to temperature stimulus [GO:0071502]; dendritic cell chemotaxis [GO:0002407]; dendritic cell differentiation [GO:0097028]; manganese ion transport [GO:0006828]; positive regulation of cellular response to oxidative stress [GO:1900409]; positive regulation of insulin secretion [GO:0032024]; protein homotetramerization [GO:0051289]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of filopodium assembly [GO:0051489]; release of sequestered calcium ion into cytosol [GO:0051209]; response to heat [GO:0009408]; response to hydroperoxide [GO:0033194]; response to purine-containing compound [GO:0014074]; temperature homeostasis [GO:0001659]; zinc ion transmembrane transport [GO:0071577]	calcium ion binding [GO:0005509]; intracellularly gated calcium channel activity [GO:0015278]; ligand-gated calcium channel activity [GO:0099604]; manganese ion transmembrane transporter activity [GO:0005384]; mono-ADP-D-ribose binding [GO:0072571]; monoatomic cation channel activity [GO:0005261]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]	GO:0001659; GO:0002407; GO:0005261; GO:0005384; GO:0005509; GO:0005764; GO:0005765; GO:0005886; GO:0006828; GO:0009408; GO:0014074; GO:0015278; GO:0030659; GO:0031410; GO:0032024; GO:0032956; GO:0033194; GO:0043025; GO:0043204; GO:0051209; GO:0051289; GO:0051489; GO:0070301; GO:0070588; GO:0071277; GO:0071502; GO:0071577; GO:0072571; GO:0097028; GO:0097553; GO:0098703; GO:0099604; GO:1900409
GN016696	GN016696.1	A0A345BJN8	26.6	297	566	919	7.69e-15	81.6	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN016697	GN016697.1	Q95JD5	35.0	257	256	296	2.08e-37	136	ST1B1_CANLF	Sulfotransferase 1B1 (ST1B1) (cSULT1B1) (EC 2.8.2.1) (Sulfotransferase family cytosolic 1B member 1)	Canis lupus familiaris (Dog) (Canis familiaris)	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	aryl sulfotransferase activity [GO:0004062]	cytoplasm [GO:0005737]	GO:0004062; GO:0005737; GO:0006068; GO:0006805; GO:0009812; GO:0030855; GO:0042403; GO:0050427; GO:0051923
GN016699	GN016699.1	Q98ST7	24.4	164	228	614	2.21e-11	66.2	MOXD1_CHICK	DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X)	Gallus gallus (Chicken)		copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]	endoplasmic reticulum membrane [GO:0005789]; secretory granule membrane [GO:0030667]	GO:0004500; GO:0005507; GO:0005789; GO:0016715; GO:0030667
GN016705	GN016705.1	Q9BX70	73.0	434	567	525	2.49e-232	654	BTBD2_HUMAN	BTB/POZ domain-containing protein 2	Homo sapiens (Human)	neurogenesis [GO:0022008]		cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; P-body [GO:0000932]	GO:0000932; GO:0005737; GO:0005829; GO:0022008; GO:0036464
GN016706	GN016706.1	P00347	53.6	886	891	887	7.12e-310	878	HMDH_CRIGR	3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; coenzyme A metabolic process [GO:0015936]; farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; geranylgeranyl diphosphate biosynthetic process [GO:0033386]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein secretion [GO:0050709]; zymosterol biosynthetic process [GO:0036197]	coenzyme A binding [GO:0120225]; GTPase regulator activity [GO:0030695]; hydroxymethylglutaryl-CoA reductase (NADPH) activity [GO:0004420]; NADPH binding [GO:0070402]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; peroxisomal membrane [GO:0005778]	GO:0004420; GO:0005778; GO:0005783; GO:0005789; GO:0010142; GO:0015936; GO:0019287; GO:0030695; GO:0033386; GO:0033489; GO:0033490; GO:0036197; GO:0042177; GO:0050709; GO:0070402; GO:0098554; GO:0120225; GO:1900222
GN016707	GN016707.1	F6RJC2	42.5	275	285	321	6.63e-62	201	CF161_BOVIN	Cilia- and flagella-associated protein 161	Bos taurus (Bovine)	cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]		axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]	GO:0005879; GO:0030317; GO:0031514; GO:0036126; GO:0060271; GO:0160111
GN016711	GN016711.1	Q9QXW2	29.9	572	560	573	1.75e-45	172	FBXW5_MOUSE	F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)	Mus musculus (Mouse)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	protein kinase binding [GO:0019901]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005737; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0080008
GN016715	GN016715.1	H9JW43	31.3	323	669	381	3.17e-42	160	CDA8_BOMMO	Chitin deacetylase 8 (BmCDA8) (EC 3.5.1.41) (Chitin deacetylase 17)	Bombyx mori (Silk moth)	polysaccharide catabolic process [GO:0000272]	chitin deacetylase activity [GO:0004099]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0000272; GO:0004099; GO:0005576; GO:0008270
GN016716	GN016716.1	Q2T9K6	58.3	624	622	617	5.33e-161	478	FEM1C_XENLA	Protein fem-1 homolog C (FEM1c) (FEM1-gamma)	Xenopus laevis (African clawed frog)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005737; GO:0016567; GO:0031462; GO:0043161; GO:0140627; GO:1990756
GN016717	GN016717.1	Q6NSJ0	24.0	595	641	714	9.70e-34	140	MYORG_HUMAN	Alpha-galactosidase MYORG (EC 3.2.1.22) (Myogenesis regulating glycosidase) (Nuclear envelope transmembrane protein 37)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; skeletal muscle fiber development [GO:0048741]	alpha-galactosidase activity [GO:0004557]	endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]	GO:0004557; GO:0005789; GO:0005975; GO:0031965; GO:0043568; GO:0048741; GO:0051897
GN016725	GN016725.1	O15033	46.0	767	1000	823	6.96e-224	660	AREL1_HUMAN	Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1)	Homo sapiens (Human)	negative regulation of apoptotic process [GO:0043066]; protein K11-linked ubiquitination [GO:0070979]; protein K33-linked ubiquitination [GO:1990390]; protein ubiquitination [GO:0016567]; regulation of inflammatory response [GO:0050727]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytosol [GO:0005829]	GO:0004842; GO:0005829; GO:0006511; GO:0016567; GO:0043066; GO:0050727; GO:0061630; GO:0070979; GO:1990390
GN016726	GN016726.1	Q5U508	43.3	522	535	522	3.71e-141	420	TBCE_XENLA	Tubulin-specific chaperone E (Tubulin-folding cofactor E)	Xenopus laevis (African clawed frog)	cytoskeleton organization [GO:0007010]; post-chaperonin tubulin folding pathway [GO:0007023]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	GO:0005737; GO:0005856; GO:0007010; GO:0007023
GN016727	GN016727.1	P55862	76.4	662	666	735	0.0	1023	MCM5A_XENLA	DNA replication licensing factor mcm5-A (xMCM5-A) (EC 3.6.4.12) (CDC46 homolog A) (xCDC46-A) (CDC46p) (p92)	Xenopus laevis (African clawed frog)	cell cycle DNA replication [GO:0044786]; DNA replication initiation [GO:0006270]; double-strand break repair via break-induced replication [GO:0000727]; premeiotic DNA replication [GO:0006279]; regulation of DNA-templated DNA replication initiation [GO:0030174]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA replication origin binding [GO:0003688]; single-stranded DNA binding [GO:0003697]; single-stranded DNA helicase activity [GO:0017116]	chromatin [GO:0000785]; chromosome [GO:0005694]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; nucleus [GO:0005634]	GO:0000727; GO:0000785; GO:0003688; GO:0003697; GO:0005524; GO:0005634; GO:0005694; GO:0006270; GO:0006279; GO:0016887; GO:0017116; GO:0030174; GO:0042555; GO:0043138; GO:0044786; GO:0071162
GN016729	GN016729.1	Q86SX6	67.3	110	145	157	4.53e-53	167	GLRX5_HUMAN	Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5)	Homo sapiens (Human)	[2Fe-2S] cluster assembly [GO:0044571]; cell redox homeostasis [GO:0045454]; hemopoiesis [GO:0030097]; intracellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226]; protein maturation [GO:0051604]		dendrite [GO:0030425]; iron-sulfur cluster assembly complex [GO:1990229]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]	GO:0005739; GO:0005759; GO:0006879; GO:0016226; GO:0030097; GO:0030425; GO:0043025; GO:0044571; GO:0045454; GO:0051604; GO:1990229
GN016730	GN016730.1	Q90980	46.0	470	896	645	1.24e-128	404	CNG3_CHICK	Cyclic nucleotide-gated channel rod photoreceptor subunit alpha (CNG channel 3) (CNG-3) (CNG3)	Gallus gallus (Chicken)	monoatomic cation transmembrane transport [GO:0098655]; sensory perception of chemical stimulus [GO:0007606]	cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]	intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; rod photoreceptor outer segment [GO:0120200]	GO:0005222; GO:0005223; GO:0005886; GO:0007606; GO:0017071; GO:0030552; GO:0030553; GO:0042622; GO:0098655; GO:0120200
GN016731	GN016731.1	P83425	31.1	132	189	213	3.76e-09	57.4	HIP_MYTED	Heavy metal-binding protein HIP	Mytilus edulis (Blue mussel)			extracellular region [GO:0005576]	GO:0005576
GN016732	GN016732.1	Q6DC60	40.0	145	163	186	4.39e-17	77.4	F219A_DANRE	Protein FAM219A	Danio rerio (Zebrafish) (Brachydanio rerio)				
GN016733	GN016733.1	Q16959	63.0	721	743	702	0.0	895	DYI2_HELCR	Dynein intermediate chain 2, ciliary	Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina)	cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158]; regionalization [GO:0003002]	dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]	outer dynein arm [GO:0036157]	GO:0003002; GO:0003341; GO:0036157; GO:0036158; GO:0045503; GO:0045504
GN016735	GN016735.1	Q0MQ89	42.4	85	235	144	1.51e-12	66.2	NDUAD_GORGO	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Complex I-B16.6) (CI-B16.6) (NADH-ubiquinone oxidoreductase B16.6 subunit)	Gorilla gorilla gorilla (Western lowland gorilla)	negative regulation of DNA-templated transcription [GO:0045892]		cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; respiratory chain complex [GO:0098803]; respiratory chain complex I [GO:0045271]	GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005743; GO:0031966; GO:0045271; GO:0045892; GO:0098803
GN016736	GN016736.1	P24329	39.4	282	312	297	3.97e-68	217	THTR_RAT	Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese)	Rattus norvegicus (Rat)	cellular detoxification of nitrogen compound [GO:0070458]; epithelial cell differentiation [GO:0030855]; iron-sulfur cluster assembly [GO:0016226]; rRNA import into mitochondrion [GO:0035928]; rRNA transport [GO:0051029]	5S rRNA binding [GO:0008097]; sulfurtransferase activity [GO:0016783]; thiosulfate-cyanide sulfurtransferase activity [GO:0004792]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004792; GO:0005739; GO:0005759; GO:0008097; GO:0016226; GO:0016783; GO:0030855; GO:0035928; GO:0051029; GO:0070458
GN016737	GN016737.1	Q9VUI3	29.6	223	532	1076	3.87e-11	69.7	EMAL_DROME	Echinoderm microtubule-associated protein-like CG42247	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; cellular response to mechanical stimulus [GO:0071260]; intracellular signal transduction [GO:0035556]; melanotic encapsulation of foreign target [GO:0035011]; microtubule cytoskeleton organization [GO:0000226]; sensory perception of sound [GO:0007605]	microtubule binding [GO:0008017]; microtubule stabilizing activity [GO:0140778]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; sensory dendrite [GO:0071683]	GO:0000226; GO:0005829; GO:0005856; GO:0007605; GO:0008017; GO:0008344; GO:0035011; GO:0035556; GO:0071260; GO:0071683; GO:0140778
GN016739	GN016739.1	P08842	42.6	549	576	583	5.16e-154	457	STS_HUMAN	Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Estrone sulfatase) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase)	Homo sapiens (Human)	epidermis development [GO:0008544]; steroid catabolic process [GO:0006706]	arylsulfatase activity [GO:0004065]; steryl-sulfatase activity [GO:0004773]; sulfuric ester hydrolase activity [GO:0008484]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004065; GO:0004773; GO:0005764; GO:0005768; GO:0005783; GO:0005788; GO:0005789; GO:0005794; GO:0005886; GO:0006706; GO:0008484; GO:0008544; GO:0016020; GO:0043231
GN016740	GN016740.1	Q9GKS9	31.3	774	630	777	7.34e-89	295	DZAN1_MACFA	Double zinc ribbon and ankyrin repeat-containing protein 1	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	eye photoreceptor cell development [GO:0042462]		centrosome [GO:0005813]	GO:0005813; GO:0042462
GN016741	GN016741.1	Q865K9	35.9	287	331	354	3.23e-55	186	MPRB_PIG	Membrane progestin receptor beta (mPR beta) (Progestin and adipoQ receptor family member VIII)	Sus scrofa (Pig)	response to steroid hormone [GO:0048545]	nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]	plasma membrane [GO:0005886]	GO:0003707; GO:0005496; GO:0005886; GO:0048545
GN016743	GN016743.1	Q6NZ04	90.5	190	295	284	2.44e-125	362	SIX1B_DANRE	Homeobox protein six1b (Homeobox protein six1a) (Sine oculis homeobox homolog 1a) (Sine oculis homeobox homolog 1b)	Danio rerio (Zebrafish) (Brachydanio rerio)	adenohypophysis development [GO:0021984]; chordate pharyngeal muscle development [GO:0043282]; extraocular skeletal muscle development [GO:0002074]; inner ear development [GO:0048839]; peripheral nervous system neuron development [GO:0048935]; regulation of skeletal muscle cell proliferation [GO:0014857]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle fiber development [GO:0048741]; striated muscle cell differentiation [GO:0051146]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000978; GO:0000981; GO:0002074; GO:0005634; GO:0005667; GO:0005737; GO:0006357; GO:0014857; GO:0021984; GO:0043282; GO:0048741; GO:0048839; GO:0048935; GO:0051146
GN016745	GN016745.1	P05419	48.6	111	115	131	5.16e-34	117	CALN_CHICK	Neo-calmodulin (NeoCaM)	Gallus gallus (Chicken)	calcineurin-mediated signaling [GO:0097720]; detection of calcium ion [GO:0005513]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	calcium ion binding [GO:0005509]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; myelin sheath [GO:0043209]; nucleus [GO:0005634]	GO:0005509; GO:0005513; GO:0005634; GO:0005737; GO:0005813; GO:0010880; GO:0043209; GO:0097720
GN016746	GN016746.1	Q2HJ98	51.4	181	373	221	1.26e-59	195	FAHD1_BOVIN	Oxaloacetate tautomerase FAHD1, mitochondrial (EC 5.3.2.2) (Acylpyruvase FAHD1) (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.112)	Bos taurus (Bovine)	oxaloacetate metabolic process [GO:0006107]	acetylpyruvate hydrolase activity [GO:0018773]; acylpyruvate hydrolase activity [GO:0047621]; fumarylpyruvate hydrolase activity [GO:0034545]; oxaloacetate decarboxylase activity [GO:0008948]; oxaloacetate tautomerase activity [GO:0050163]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005739; GO:0005829; GO:0006107; GO:0008948; GO:0018773; GO:0034545; GO:0047621; GO:0050163
GN016747	GN016747.1	P04464	42.8	166	199	149	2.54e-42	142	CALM_WHEAT	Calmodulin (CaM)	Triticum aestivum (Wheat)		calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]	GO:0005509; GO:0005737; GO:0019904; GO:0030234
GN016748	GN016748.1	P06707	35.7	129	200	150	2.68e-17	78.2	TNNC1_PONLE	Troponin C, isotype alpha	Pontastacus leptodactylus (Turkish narrow-clawed crayfish) (Astacus leptodactylus)		calcium ion binding [GO:0005509]	myosin II complex [GO:0016460]	GO:0005509; GO:0016460
GN016749	GN016749.1	Q6R3M4	50.9	393	747	717	6.72e-121	382	POLI_MOUSE	DNA polymerase iota (EC 2.7.7.7) (Rad30 homolog B)	Mus musculus (Mouse)	cellular response to UV-C [GO:0071494]; DNA repair [GO:0006281]; translesion synthesis [GO:0019985]	damaged DNA binding [GO:0003684]; DNA polymerase activity [GO:0034061]; DNA-directed DNA polymerase activity [GO:0003887]	cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0003684; GO:0003887; GO:0005634; GO:0006281; GO:0016607; GO:0019985; GO:0034061; GO:0036464; GO:0071494
GN016750	GN016750.1	Q2TB18	27.3	513	537	679	4.94e-50	186	ASTE1_HUMAN	Single-strand DNA endonuclease ASTE1 (EC 3.1.-.-) (Protein asteroid homolog 1)	Homo sapiens (Human)	double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]	3' overhang single-stranded DNA endonuclease activity [GO:1990599]; single-stranded DNA endonuclease activity [GO:0000014]		GO:0000014; GO:0000724; GO:0006303; GO:1990599
GN016755	GN016755.1	O95149	50.0	314	797	360	3.05e-94	301	SPN1_HUMAN	Snurportin-1 (RNA U transporter 1)	Homo sapiens (Human)	cytoskeleton organization [GO:0007010]; protein complex oligomerization [GO:0051259]; protein import into nucleus [GO:0006606]; protein tetramerization [GO:0051262]; RNA import into nucleus [GO:0006404]; snRNA import into nucleus [GO:0061015]	nuclear import signal receptor activity [GO:0061608]; RNA cap binding [GO:0000339]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; NLS-dependent protein nuclear import complex [GO:0042564]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000339; GO:0005634; GO:0005643; GO:0005654; GO:0005737; GO:0005829; GO:0006404; GO:0006606; GO:0007010; GO:0042564; GO:0051259; GO:0051262; GO:0061015; GO:0061608
GN016756	GN016756.1	Q9NVM6	64.8	91	103	304	8.82e-33	118	DJC17_HUMAN	DnaJ homolog subfamily C member 17	Homo sapiens (Human)	spliceosomal complex disassembly [GO:0000390]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	GO:0000390; GO:0003723; GO:0005634; GO:0005681; GO:0005737
GN016760	GN016760.1	Q9W4Y2	24.9	321	441	669	5.41e-16	84.0	PDFR_DROME	PDF receptor (Pigment-dispersing factor receptor) (Protein groom-of-PDF)	Drosophila melanogaster (Fruit fly)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; circadian rhythm [GO:0007623]; circadian sleep/wake cycle [GO:0042745]; circadian temperature homeostasis [GO:0060086]; copper ion homeostasis [GO:0055070]; G protein-coupled receptor signaling pathway [GO:0007186]; gravitaxis [GO:0042332]; locomotor rhythm [GO:0045475]; neuropeptide signaling pathway [GO:0007218]; positive regulation of calcium-mediated signaling [GO:0050850]; regulation of circadian rhythm [GO:0042752]; regulation of circadian sleep/wake cycle [GO:0042749]; response to paraquat [GO:1901562]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	GO:0005886; GO:0007166; GO:0007186; GO:0007188; GO:0007189; GO:0007218; GO:0007623; GO:0008188; GO:0008528; GO:0016020; GO:0042332; GO:0042745; GO:0042749; GO:0042752; GO:0043005; GO:0043025; GO:0045475; GO:0048512; GO:0050850; GO:0055070; GO:0060086; GO:1901562
GN016764	GN016764.1	Q7TQC7	33.2	503	429	527	5.74e-37	144	GPTC2_MOUSE	G patch domain-containing protein 2	Mus musculus (Mouse)	cell population proliferation [GO:0008283]	nucleic acid binding [GO:0003676]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003676; GO:0005634; GO:0005730; GO:0008283; GO:0016607
GN016767	GN016767.1	Q8IYT3	30.8	542	841	715	1.53e-65	236	CC170_HUMAN	Coiled-coil domain-containing protein 170	Homo sapiens (Human)	microtubule cytoskeleton organization [GO:0000226]	microtubule binding [GO:0008017]	ciliary basal body [GO:0036064]; Golgi apparatus [GO:0005794]	GO:0000226; GO:0005794; GO:0008017; GO:0036064
GN016769	GN016769.1	Q58EM4	47.2	254	259	448	1.02e-77	244	ARMT1_DANRE	Damage-control phosphatase 1 (EC 3.1.3.-) (Acidic residue methyltransferase 1) (Protein-glutamate O-methyltransferase) (EC 2.1.1.-) (Sugar phosphate phosphatase ARMT1)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA damage response [GO:0006974]	fructose 6-phosphate aldolase activity [GO:0097023]; fructose-1-phosphatase activity [GO:0103026]; phosphatase activity [GO:0016791]; protein carboxyl O-methyltransferase activity [GO:0051998]; protein-glutamate O-methyltransferase activity [GO:0008983]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]		GO:0006974; GO:0008757; GO:0008983; GO:0016791; GO:0051998; GO:0097023; GO:0103026
GN016773	GN016773.1	Q9CQG1	60.0	170	176	178	2.16e-73	221	CHAC2_MOUSE	Putative glutathione-specific gamma-glutamylcyclotransferase 2 (Gamma-GCG 2) (EC 4.3.2.7) (Cation transport regulator-like protein 2)	Mus musculus (Mouse)	glutathione catabolic process [GO:0006751]	glutathione specific gamma-glutamylcyclotransferase activity [GO:0061928]	cytosol [GO:0005829]	GO:0005829; GO:0006751; GO:0061928
GN016774	GN016774.1	X1WBB5	25.2	278	284	276	3.30e-18	85.5	ZDH22_DANRE	Palmitoyltransferase ZDHHC22 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 22) (Zinc finger DHHC domain-containing protein 22)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein targeting to membrane [GO:0006612]	protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005783; GO:0005789; GO:0006612; GO:0019706
GN016775	GN016775.1	Q3T106	56.2	73	322	235	1.96e-16	80.5	SRSF7_BOVIN	Serine/arginine-rich splicing factor 7 (Splicing factor, arginine/serine-rich 7)	Bos taurus (Bovine)	negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000381; GO:0003723; GO:0005634; GO:0005737; GO:0008270; GO:0048025
GN016777	GN016777.1	Q9ERS1	55.1	301	292	430	4.23e-94	287	KCNKC_RAT	Potassium channel subfamily K member 12 (Tandem pore domain halothane-inhibited potassium channel 2) (THIK-2)	Rattus norvegicus (Rat)		identical protein binding [GO:0042802]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; protein heterodimerization activity [GO:0046982]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0005267; GO:0005789; GO:0005886; GO:0022841; GO:0042802; GO:0046982
GN016778	GN016778.1	Q00454	63.6	99	103	149	4.23e-43	140	RL27A_TETTH	Large ribosomal subunit protein uL15 (60S ribosomal protein L27a)	Tetrahymena thermophila	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]	GO:0003735; GO:0006412; GO:0022625
GN016782	GN016782.1	Q9ERS1	55.1	301	292	430	4.23e-94	287	KCNKC_RAT	Potassium channel subfamily K member 12 (Tandem pore domain halothane-inhibited potassium channel 2) (THIK-2)	Rattus norvegicus (Rat)		identical protein binding [GO:0042802]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; protein heterodimerization activity [GO:0046982]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0005267; GO:0005789; GO:0005886; GO:0022841; GO:0042802; GO:0046982
GN016786	GN016786.1	Q62318	26.7	202	639	834	2.84e-17	89.7	TIF1B_MOUSE	Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-A-interacting protein) (KRIP-1) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; chromatin organization [GO:0006325]; convergent extension involved in axis elongation [GO:0060028]; DNA damage response [GO:0006974]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epigenetic programming of gene expression [GO:0043045]; epithelial to mesenchymal transition [GO:0001837]; genomic imprinting [GO:0071514]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of type I interferon production [GO:0032481]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; suppression of viral release by host [GO:0044790]	chromatin binding [GO:0003682]; chromatin-protein adaptor activity [GO:0140463]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; promoter-specific chromatin binding [GO:1990841]; protein kinase activity [GO:0004672]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; euchromatin [GO:0000791]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000785; GO:0000791; GO:0000792; GO:0001701; GO:0001837; GO:0003677; GO:0003682; GO:0003713; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0006281; GO:0006325; GO:0006346; GO:0006468; GO:0006974; GO:0007566; GO:0008270; GO:0016567; GO:0016925; GO:0019789; GO:0031625; GO:0032481; GO:0032991; GO:0035851; GO:0042307; GO:0043045; GO:0043124; GO:0043161; GO:0044790; GO:0045087; GO:0045739; GO:0045869; GO:0045892; GO:0045893; GO:0046777; GO:0060028; GO:0060669; GO:0061630; GO:0061665; GO:0070087; GO:0071514; GO:0090575; GO:0140374; GO:0140463; GO:1990841
GN016787	GN016787.1	P51587	37.4	689	2860	3418	2.30e-114	413	BRCA2_HUMAN	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein)	Homo sapiens (Human)	cellular response to ionizing radiation [GO:0071479]; centrosome duplication [GO:0051298]; DNA damage response [GO:0006974]; DNA recombinase assembly [GO:0000730]; double-strand break repair [GO:0006302]; double-strand break repair involved in meiotic recombination [GO:1990918]; double-strand break repair via homologous recombination [GO:0000724]; establishment of protein localization to telomere [GO:0070200]; male meiosis I [GO:0007141]; mitotic recombination-dependent replication fork processing [GO:1990426]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA damage checkpoint [GO:2000001]; telomere maintenance via recombination [GO:0000722]	double-stranded DNA binding [GO:0003690]; gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; protease binding [GO:0002020]; protein-macromolecule adaptor activity [GO:0030674]; single-stranded DNA binding [GO:0003697]	BRCA2-MAGE-D1 complex [GO:0033593]; centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; DNA repair complex [GO:1990391]; lateral element [GO:0000800]; nuclear ubiquitin ligase complex [GO:0000152]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; secretory granule [GO:0030141]; site of double-strand break [GO:0035861]	GO:0000152; GO:0000722; GO:0000724; GO:0000730; GO:0000781; GO:0000800; GO:0002020; GO:0003690; GO:0003697; GO:0005634; GO:0005654; GO:0005813; GO:0005829; GO:0006289; GO:0006302; GO:0006974; GO:0007141; GO:0030141; GO:0030674; GO:0032991; GO:0033593; GO:0033600; GO:0035861; GO:0042802; GO:0043015; GO:0045893; GO:0051298; GO:0070200; GO:0071479; GO:0140678; GO:1990391; GO:1990426; GO:1990918; GO:2000001
GN016789	GN016789.1	H2A0M3	43.9	742	789	781	5.58e-198	584	AMO_PINMG	Putative amine oxidase [copper-containing] (EC 1.4.3.-)	Margaritifera margaritifera (Freshwater pearl mussel)	amine metabolic process [GO:0009308]	copper ion binding [GO:0005507]; primary methylamine oxidase activity [GO:0008131]; quinone binding [GO:0048038]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005507; GO:0005576; GO:0005886; GO:0008131; GO:0009308; GO:0048038
GN016790	GN016790.1	H2A0M3	43.4	740	788	781	1.93e-195	578	AMO_PINMG	Putative amine oxidase [copper-containing] (EC 1.4.3.-)	Margaritifera margaritifera (Freshwater pearl mussel)	amine metabolic process [GO:0009308]	copper ion binding [GO:0005507]; primary methylamine oxidase activity [GO:0008131]; quinone binding [GO:0048038]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005507; GO:0005576; GO:0005886; GO:0008131; GO:0009308; GO:0048038
GN016792	GN016792.1	H2A0M3	34.5	171	240	781	2.26e-21	95.9	AMO_PINMG	Putative amine oxidase [copper-containing] (EC 1.4.3.-)	Margaritifera margaritifera (Freshwater pearl mussel)	amine metabolic process [GO:0009308]	copper ion binding [GO:0005507]; primary methylamine oxidase activity [GO:0008131]; quinone binding [GO:0048038]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005507; GO:0005576; GO:0005886; GO:0008131; GO:0009308; GO:0048038
GN016793	GN016793.1	H2A0M3	47.6	508	527	781	9.41e-150	451	AMO_PINMG	Putative amine oxidase [copper-containing] (EC 1.4.3.-)	Margaritifera margaritifera (Freshwater pearl mussel)	amine metabolic process [GO:0009308]	copper ion binding [GO:0005507]; primary methylamine oxidase activity [GO:0008131]; quinone binding [GO:0048038]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005507; GO:0005576; GO:0005886; GO:0008131; GO:0009308; GO:0048038
GN016794	GN016794.1	A0A8M1PLI9	69.1	540	538	540	5.21e-278	769	AL7A1_DANRE	Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8)	Danio rerio (Zebrafish) (Brachydanio rerio)	camera-type eye development [GO:0043010]; cartilage development [GO:0051216]; energy homeostasis [GO:0097009]; glycine betaine biosynthetic process from choline [GO:0019285]; L-lysine catabolic process [GO:0019477]; negative regulation of endosome to plasma membrane protein transport [GO:1905750]; negative regulation of ferroptosis [GO:0110076]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; pectoral fin development [GO:0033339]	aldehyde dehydrogenase (NAD+) activity [GO:0004029]; alpha-aminoadipate acetyltransferase activity [GO:0043741]; betaine-aldehyde dehydrogenase (NAD+) activity [GO:0008802]; L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity [GO:0004043]	cytosol [GO:0005829]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000139; GO:0004029; GO:0004043; GO:0005634; GO:0005739; GO:0005829; GO:0005886; GO:0008802; GO:0019285; GO:0019477; GO:0033339; GO:0042997; GO:0043010; GO:0043741; GO:0051216; GO:0097009; GO:0110076; GO:1905750
GN016800	GN016800.1	O02373	67.2	360	366	476	5.12e-177	503	UGDH_DROME	UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (Protein sugarless) (Protein suppenkasper)	Drosophila melanogaster (Fruit fly)	chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; epithelial cell migration, open tracheal system [GO:0007427]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; mesoderm migration involved in gastrulation [GO:0007509]; segment polarity determination [GO:0007367]; UDP-glucuronate biosynthetic process [GO:0006065]	NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003979; GO:0005634; GO:0005737; GO:0005829; GO:0006024; GO:0006065; GO:0007367; GO:0007427; GO:0007509; GO:0008543; GO:0015012; GO:0050650; GO:0051287
GN016802	GN016802.1	Q7XPJ0	55.9	381	1849	1248	2.84e-107	377	KN14I_ORYSJ	Kinesin-like protein KIN-14I (Kinesin-like calmodulin-binding protein) (OsKCBP)	Oryza sativa subsp. japonica (Rice)	microtubule-based movement [GO:0007018]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; oxidoreductase activity [GO:0016491]	kinesin complex [GO:0005871]	GO:0003777; GO:0005524; GO:0005871; GO:0007018; GO:0008017; GO:0016491
GN016803	GN016803.1	Q8BLI0	29.1	914	951	1745	1.02e-113	387	ATL1_MOUSE	ADAMTS-like protein 1 (ADAMTSL-1) (Punctin-1)	Mus musculus (Mouse)	extracellular matrix organization [GO:0030198]		extracellular matrix [GO:0031012]	GO:0030198; GO:0031012
GN016807	GN016807.1	Q8CEQ0	67.3	361	360	352	3.09e-173	488	CDKL1_MOUSE	Cyclin-dependent kinase-like 1 (EC 2.7.11.22)	Mus musculus (Mouse)	heart development [GO:0007507]; regulation of cilium assembly [GO:1902017]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]	centriole [GO:0005814]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; sperm midpiece [GO:0097225]	GO:0004693; GO:0005524; GO:0005654; GO:0005737; GO:0005814; GO:0007507; GO:0035869; GO:0097225; GO:0106310; GO:1902017
GN016808	GN016808.1	A4IIL4	51.4	385	418	411	3.87e-135	396	BROX_XENTR	BRO1 domain-containing protein BROX (BRO1 domain- and CAAX motif-containing protein)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mitotic nuclear membrane reassembly [GO:0007084]		nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]	GO:0005635; GO:0007084; GO:0031965
GN016809	GN016809.1	A0A2B4RNI3	32.9	249	726	688	3.04e-25	115	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN016810	GN016810.1	A0A2B4RNI3	33.6	223	726	688	5.34e-25	114	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN016811	GN016811.1	Q9BXJ7	30.0	360	521	453	5.14e-31	128	AMNLS_HUMAN	Protein amnionless [Cleaved into: Soluble protein amnionless]	Homo sapiens (Human)	cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein localization [GO:0008104]; receptor-mediated endocytosis [GO:0006898]; renal protein absorption [GO:0097017]	cargo receptor activity [GO:0038024]; signaling receptor binding [GO:0005102]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; endocytic vesicle [GO:0030139]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0005102; GO:0005576; GO:0005886; GO:0006898; GO:0008104; GO:0009235; GO:0010008; GO:0015889; GO:0016020; GO:0016324; GO:0030139; GO:0031526; GO:0031528; GO:0038024; GO:0043001; GO:0043235; GO:0070062; GO:0097017
GN016813	GN016813.1	B3EWZ3	42.3	239	236	1675	1.41e-57	200	CADN_ACRMI	Coadhesin	Acropora millepora (Staghorn coral) (Heteropora millepora)			membrane [GO:0016020]	GO:0016020
GN016817	GN016817.1	Q9CZJ2	34.5	629	565	685	1.17e-96	311	HS12B_MOUSE	Heat shock 70 kDa protein 12B	Mus musculus (Mouse)	angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]			GO:0001525; GO:0043542
GN016820	GN016820.1	Q3V0Q6	38.4	185	204	470	1.86e-30	119	SPAG8_MOUSE	Sperm-associated antigen 8 (Sperm membrane protein 1) (SMP-1) (Sperm membrane protein BS-84)	Mus musculus (Mouse)	flagellated sperm motility [GO:0030317]; positive regulation of transcription by RNA polymerase II [GO:0045944]	microtubule binding [GO:0008017]	acrosomal vesicle [GO:0001669]; axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm end piece [GO:0097229]; sperm flagellum [GO:0036126]; sperm principal piece [GO:0097228]; spindle [GO:0005819]	GO:0001669; GO:0005634; GO:0005654; GO:0005737; GO:0005815; GO:0005819; GO:0005829; GO:0005879; GO:0005929; GO:0008017; GO:0030317; GO:0036126; GO:0045944; GO:0097228; GO:0097229; GO:0160111
GN016821	GN016821.1	Q8BGF9	29.1	299	292	314	6.25e-27	110	S2544_MOUSE	Solute carrier family 25 member 44	Mus musculus (Mouse)	branched-chain amino acid catabolic process [GO:0009083]; branched-chain amino acid transport [GO:0015803]; regulation of cold-induced thermogenesis [GO:0120161]	branched-chain amino acid transmembrane transporter activity [GO:0015658]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0009083; GO:0015658; GO:0015803; GO:0120161
GN016822	GN016822.1	Q9D361	34.9	261	356	337	6.97e-28	114	SNR48_MOUSE	U11/U12 small nuclear ribonucleoprotein 48 kDa protein (U11/U12 snRNP 48 kDa protein)	Mus musculus (Mouse)			cytosol [GO:0005829]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U11/U12 snRNP [GO:0034693]; U12-type precatalytic spliceosome [GO:0071016]; U12-type spliceosomal complex [GO:0005689]	GO:0005654; GO:0005681; GO:0005689; GO:0005829; GO:0034693; GO:0071016
GN016825	GN016825.1	P86251	54.5	400	463	452	2.27e-148	433	EFTU_MESAU	Elongation factor Tu, mitochondrial (EF-Tu) (EC 3.6.5.3)	Mesocricetus auratus (Golden hamster)	mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; translation elongation factor activity [GO:0003746]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0000287; GO:0003746; GO:0003924; GO:0005525; GO:0005739; GO:0005759; GO:0032543; GO:0070125
GN016828	GN016828.1	O60140	34.6	263	767	495	2.79e-38	152	YNS9_SCHPO	Uncharacterized protein C18H10.09	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	rescue of stalled cytosolic ribosome [GO:0072344]	zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0008270; GO:0072344
GN016829	GN016829.1	Q5XIS7	33.5	191	625	502	3.75e-09	63.2	UBAP1_RAT	Ubiquitin-associated protein 1 (UBAP-1)	Rattus norvegicus (Rat)	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	ubiquitin binding [GO:0043130]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; ESCRT I complex [GO:0000813]	GO:0000813; GO:0005737; GO:0005768; GO:0005829; GO:0043130; GO:0043162
GN016830	GN016830.1	O35815	56.8	234	356	355	3.62e-81	254	ATX3_RAT	Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1 homolog)	Rattus norvegicus (Rat)	actin cytoskeleton organization [GO:0030036]; cellular response to amino acid starvation [GO:0034198]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; chromatin remodeling [GO:0006338]; exploration behavior [GO:0035640]; intermediate filament cytoskeleton organization [GO:0045104]; microtubule cytoskeleton organization [GO:0000226]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of ERAD pathway [GO:1904294]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein localization to cytosolic proteasome complex [GO:1904327]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of cell-substrate adhesion [GO:0010810]; ubiquitin-dependent protein catabolic process [GO:0006511]	ATPase binding [GO:0051117]; cysteine-type deubiquitinase activity [GO:0004843]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; nuclear inclusion body [GO:0042405]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]	GO:0000226; GO:0000977; GO:0001222; GO:0004843; GO:0005634; GO:0005737; GO:0005759; GO:0005765; GO:0005789; GO:0005829; GO:0006338; GO:0006511; GO:0006515; GO:0010810; GO:0016363; GO:0030036; GO:0031625; GO:0031966; GO:0034198; GO:0034605; GO:0035520; GO:0035640; GO:0042405; GO:0042802; GO:0042826; GO:0043161; GO:0045104; GO:0051117; GO:0061578; GO:0070536; GO:0071108; GO:0071218; GO:1904262; GO:1904294; GO:1904327; GO:1990380; GO:2000060
GN016831	GN016831.1	P05419	93.8	81	91	131	2.02e-48	152	CALN_CHICK	Neo-calmodulin (NeoCaM)	Gallus gallus (Chicken)	calcineurin-mediated signaling [GO:0097720]; detection of calcium ion [GO:0005513]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	calcium ion binding [GO:0005509]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; myelin sheath [GO:0043209]; nucleus [GO:0005634]	GO:0005509; GO:0005513; GO:0005634; GO:0005737; GO:0005813; GO:0010880; GO:0043209; GO:0097720
GN016832	GN016832.1	P02597	63.6	77	77	149	7.82e-24	90.5	CALMS_CHICK	Calmodulin, striated muscle	Gallus gallus (Chicken)	calcineurin-mediated signaling [GO:0097720]; detection of calcium ion [GO:0005513]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	calcium ion binding [GO:0005509]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; myelin sheath [GO:0043209]; nucleus [GO:0005634]	GO:0005509; GO:0005513; GO:0005634; GO:0005737; GO:0005813; GO:0010880; GO:0043209; GO:0097720
GN016833	GN016833.1	P05419	84.4	64	81	131	2.43e-30	106	CALN_CHICK	Neo-calmodulin (NeoCaM)	Gallus gallus (Chicken)	calcineurin-mediated signaling [GO:0097720]; detection of calcium ion [GO:0005513]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	calcium ion binding [GO:0005509]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; myelin sheath [GO:0043209]; nucleus [GO:0005634]	GO:0005509; GO:0005513; GO:0005634; GO:0005737; GO:0005813; GO:0010880; GO:0043209; GO:0097720
GN016834	GN016834.1	Q40302	71.2	73	141	149	2.20e-28	104	CALM_MACPY	Calmodulin (CaM)	Macrocystis pyrifera (Giant kelp) (Fucus pyrifer)		calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; myosin II complex [GO:0016460]	GO:0005509; GO:0005737; GO:0016460
GN016836	GN016836.1	Q40302	59.9	147	429	149	1.76e-51	173	CALM_MACPY	Calmodulin (CaM)	Macrocystis pyrifera (Giant kelp) (Fucus pyrifer)		calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; myosin II complex [GO:0016460]	GO:0005509; GO:0005737; GO:0016460
GN016837	GN016837.1	P05419	48.2	56	70	131	3.50e-11	57.4	CALN_CHICK	Neo-calmodulin (NeoCaM)	Gallus gallus (Chicken)	calcineurin-mediated signaling [GO:0097720]; detection of calcium ion [GO:0005513]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	calcium ion binding [GO:0005509]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; myelin sheath [GO:0043209]; nucleus [GO:0005634]	GO:0005509; GO:0005513; GO:0005634; GO:0005737; GO:0005813; GO:0010880; GO:0043209; GO:0097720
GN016838	GN016838.1	Q40302	63.2	144	168	149	2.59e-61	189	CALM_MACPY	Calmodulin (CaM)	Macrocystis pyrifera (Giant kelp) (Fucus pyrifer)		calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; myosin II complex [GO:0016460]	GO:0005509; GO:0005737; GO:0016460
GN016839	GN016839.1	Q9W2H1	59.1	127	150	178	1.63e-44	147	TM2D1_DROME	TM2 domain-containing protein biscotti (TM2D1)	Drosophila melanogaster (Fruit fly)	positive regulation of Notch signaling pathway [GO:0045747]		plasma membrane [GO:0005886]	GO:0005886; GO:0045747
GN016840	GN016840.1	Q5R5L7	35.2	321	387	414	1.46e-52	183	ARRD3_PONAB	Arrestin domain-containing protein 3	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	protein transport [GO:0015031]		cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0015031
GN016843	GN016843.1	B1AS29	31.4	442	471	919	2.08e-52	193	GRIK3_MOUSE	Glutamate receptor ionotropic, kainate 3 (GluK3) (Glutamate receptor 7) (GluR-7) (GluR7)	Mus musculus (Mouse)	G protein-coupled glutamate receptor signaling pathway [GO:0007216]; glutamate receptor signaling pathway [GO:0007215]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; regulation of membrane potential [GO:0042391]; synaptic transmission, glutamatergic [GO:0035249]	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; glutamate receptor activity [GO:0008066]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; identical protein binding [GO:0042802]; kainate selective glutamate receptor activity [GO:0015277]; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099507]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	axon [GO:0030424]; cochlear hair cell ribbon synapse [GO:0098683]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; kainate selective glutamate receptor complex [GO:0032983]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; terminal bouton [GO:0043195]	GO:0001640; GO:0004970; GO:0005886; GO:0007215; GO:0007216; GO:0008066; GO:0015277; GO:0022849; GO:0030424; GO:0030425; GO:0032839; GO:0032983; GO:0035249; GO:0042391; GO:0042734; GO:0042802; GO:0043195; GO:0043204; GO:0045211; GO:0050804; GO:0051967; GO:0098683; GO:0098839; GO:0098978; GO:0099507; GO:1904315
GN016844	GN016844.1	Q96JK4	41.8	251	232	782	1.52e-50	178	HIPL1_HUMAN	HHIP-like protein 1	Homo sapiens (Human)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN016846	GN016846.1	P38584	54.2	365	412	377	1.11e-124	368	TTL_BOVIN	Tubulin--tyrosine ligase (TTL) (EC 6.3.2.25)	Bos taurus (Bovine)	microtubule cytoskeleton organization [GO:0000226]	tubulin-tyrosine ligase activity [GO:0004835]	cytosol [GO:0005829]; spindle microtubule [GO:0005876]	GO:0000226; GO:0004835; GO:0005829; GO:0005876
GN016847	GN016847.1	Q6P158	48.8	1353	1396	1386	0.0	1171	DHX57_HUMAN	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57)	Homo sapiens (Human)	positive regulation of translation [GO:0045727]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; helicase activity [GO:0004386]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA polymerase binding [GO:0070063]		GO:0003723; GO:0003724; GO:0004386; GO:0005524; GO:0016887; GO:0045727; GO:0046872; GO:0070063
GN016848	GN016848.1	Q9EQC5	47.0	766	891	806	1.10e-223	655	SCYL1_MOUSE	N-terminal kinase-like protein (105 kDa kinase-like protein) (Mitosis-associated kinase-like protein NTKL) (SCY1-like protein 1)	Mus musculus (Mouse)	inflammatory response [GO:0006954]; intracellular protein localization [GO:0008104]; neuron development [GO:0048666]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; spinal cord motor neuron differentiation [GO:0021522]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]	centrosome [GO:0005813]; cis-Golgi network [GO:0005801]; COPI vesicle coat [GO:0030126]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]	GO:0004672; GO:0005524; GO:0005737; GO:0005793; GO:0005794; GO:0005801; GO:0005813; GO:0005829; GO:0006890; GO:0006954; GO:0008104; GO:0021522; GO:0030126; GO:0048666
GN016849	GN016849.1	Q3ZCK3	52.8	307	394	308	2.80e-116	343	BPNT1_BOVIN	3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (Bisphosphate 3'-nucleotidase 1) (BPntase 1) (Inositol-polyphosphate 1-phosphatase) (EC 3.1.3.57)	Bos taurus (Bovine)	phosphatidylinositol phosphate biosynthetic process [GO:0046854]	3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; inositol-1,4-bisphosphate 1-phosphatase activity [GO:0004441]		GO:0004441; GO:0008441; GO:0046854
GN016850	GN016850.1	Q24212	48.7	495	794	1262	3.83e-143	456	STNB_DROME	Protein stoned-B (Stn-B) (StonedB)	Drosophila melanogaster (Fruit fly)	chemical synaptic transmission [GO:0007268]; clathrin-dependent endocytosis [GO:0072583]; regulation of endocytosis [GO:0030100]; regulation of synaptic vesicle endocytosis [GO:1900242]; synaptic vesicle cycle [GO:0099504]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle transport [GO:0048489]	clathrin-cargo adaptor activity [GO:0035615]; scaffold protein binding [GO:0097110]	AP-2 adaptor complex [GO:0030122]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; presynaptic active zone [GO:0048786]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]	GO:0005737; GO:0005829; GO:0007268; GO:0008021; GO:0030100; GO:0030122; GO:0030139; GO:0035615; GO:0045202; GO:0048488; GO:0048489; GO:0048786; GO:0072583; GO:0097110; GO:0099504; GO:1900242
GN016851	GN016851.1	P70099	87.3	339	338	339	1.01e-211	584	RAD51_CRIGR	DNA repair protein RAD51 homolog 1 (EC 3.6.4.-)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	cellular response to camptothecin [GO:0072757]; cellular response to ionizing radiation [GO:0071479]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA damage response [GO:0006974]; DNA recombinase assembly [GO:0000730]; DNA strand invasion [GO:0042148]; double-strand break repair involved in meiotic recombination [GO:1990918]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; meiotic cell cycle [GO:0051321]; mitotic recombination-dependent replication fork processing [GO:1990426]; regulation of double-strand break repair via homologous recombination [GO:0010569]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomere lengthening [GO:0010833]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA polymerase binding [GO:0070182]; DNA strand exchange activity [GO:0000150]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; nucleosome binding [GO:0031491]; single-stranded DNA binding [GO:0003697]	centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral element [GO:0000800]; mitochondrial matrix [GO:0005759]; nuclear chromosome [GO:0000228]; nuclear ubiquitin ligase complex [GO:0000152]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; presynaptic intermediate filament cytoskeleton [GO:0099182]; protein-DNA complex [GO:0032993]; site of double-strand break [GO:0035861]	GO:0000150; GO:0000152; GO:0000228; GO:0000722; GO:0000724; GO:0000730; GO:0000781; GO:0000785; GO:0000793; GO:0000794; GO:0000800; GO:0003690; GO:0003697; GO:0005524; GO:0005634; GO:0005694; GO:0005730; GO:0005737; GO:0005759; GO:0005813; GO:0005829; GO:0006974; GO:0010569; GO:0010833; GO:0016605; GO:0016887; GO:0031491; GO:0032993; GO:0035861; GO:0036297; GO:0042148; GO:0042802; GO:0048471; GO:0051321; GO:0070182; GO:0070192; GO:0071479; GO:0072757; GO:0099182; GO:0140664; GO:1990426; GO:1990918
GN016852	GN016852.1	Q05901	31.3	268	338	458	4.54e-31	125	ACHB3_HUMAN	Neuronal acetylcholine receptor subunit beta-3	Homo sapiens (Human)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007271; GO:0007274; GO:0015267; GO:0016020; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0098793; GO:0099171
GN016853	GN016853.1	P09481	33.1	175	264	496	6.66e-29	117	ACHA3_CHICK	Neuronal acetylcholine receptor subunit alpha-3	Gallus gallus (Chicken)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of appetite [GO:0032098]; response to nicotine [GO:0035094]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005783; GO:0005794; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0022848; GO:0030594; GO:0032098; GO:0034220; GO:0035094; GO:0035095; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060; GO:0098793; GO:0099171
GN016856	GN016856.1	O45782	29.3	304	288	426	1.77e-32	127	ARD17_CAEEL	Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1)	Caenorhabditis elegans		molecular adaptor activity [GO:0060090]; protein phosphatase 2B binding [GO:0030346]	cytoplasm [GO:0005737]	GO:0005737; GO:0030346; GO:0060090
GN016857	GN016857.1	Q7TPQ9	36.8	212	317	414	1.11e-38	144	ARRD3_MOUSE	Arrestin domain-containing protein 3	Mus musculus (Mouse)	fat pad development [GO:0060613]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of heat generation [GO:0031651]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; positive regulation of hippo signaling [GO:0035332]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; response to mechanical stimulus [GO:0009612]; skin development [GO:0043588]; temperature homeostasis [GO:0001659]	beta-3 adrenergic receptor binding [GO:0031699]; molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0001659; GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0009612; GO:0031651; GO:0031699; GO:0035332; GO:0043588; GO:0051443; GO:0060090; GO:0060613; GO:0071878; GO:0090327; GO:0120163
GN016858	GN016858.1	Q7TPQ9	34.9	315	410	414	4.42e-55	190	ARRD3_MOUSE	Arrestin domain-containing protein 3	Mus musculus (Mouse)	fat pad development [GO:0060613]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of heat generation [GO:0031651]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; positive regulation of hippo signaling [GO:0035332]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; response to mechanical stimulus [GO:0009612]; skin development [GO:0043588]; temperature homeostasis [GO:0001659]	beta-3 adrenergic receptor binding [GO:0031699]; molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0001659; GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0009612; GO:0031651; GO:0031699; GO:0035332; GO:0043588; GO:0051443; GO:0060090; GO:0060613; GO:0071878; GO:0090327; GO:0120163
GN016859	GN016859.1	Q5R5L7	32.6	279	339	414	5.27e-38	143	ARRD3_PONAB	Arrestin domain-containing protein 3	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	protein transport [GO:0015031]		cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0015031
GN016860	GN016860.1	Q9V4X2	44.4	81	314	184	1.46e-13	71.2	PGSC2_DROME	Peptidoglycan-recognition protein SC2 (EC 3.5.1.28)	Drosophila melanogaster (Fruit fly)	defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0002814]; negative regulation of peptidoglycan recognition protein signaling pathway [GO:0061060]; peptidoglycan catabolic process [GO:0009253]; Toll receptor ligand protein activation cascade [GO:0160032]	N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0002814; GO:0005576; GO:0006955; GO:0008270; GO:0008745; GO:0009253; GO:0016019; GO:0042834; GO:0045087; GO:0050830; GO:0061060; GO:0160032
GN016862	GN016862.1	Q9NP81	48.6	321	443	518	2.36e-97	304	SYSM_HUMAN	Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)	Homo sapiens (Human)	mitochondrial seryl-tRNA aminoacylation [GO:0070158]; seryl-tRNA aminoacylation [GO:0006434]	ATP binding [GO:0005524]; RNA binding [GO:0003723]; serine-tRNA ligase activity [GO:0004828]; tRNA binding [GO:0000049]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0000049; GO:0003723; GO:0004828; GO:0005524; GO:0005739; GO:0005759; GO:0006434; GO:0070158
GN016863	GN016863.1	Q6GLJ1	25.3	438	478	470	3.92e-27	117	BTBDH_XENLA	BTB/POZ domain-containing protein 17	Xenopus laevis (African clawed frog)			extracellular region [GO:0005576]	GO:0005576
GN016864	GN016864.1	P36776	56.6	900	1013	959	0.0	978	LONM_HUMAN	Lon protease homolog, mitochondrial (EC 3.4.21.53) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Mitochondrial chaperone LONP1) (EC 3.6.4.10) (Serine protease 15)	Homo sapiens (Human)	'de novo' protein folding [GO:0006458]; cellular response to oxidative stress [GO:0034599]; chaperone-mediated protein complex assembly [GO:0051131]; mitochondrial protein catabolic process [GO:0035694]; mitochondrion organization [GO:0007005]; oxidation-dependent protein catabolic process [GO:0070407]; protein catabolic process [GO:0030163]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis [GO:0006508]; response to aluminum ion [GO:0010044]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; ATP-dependent protein folding chaperone [GO:0140662]; DNA polymerase binding [GO:0070182]; G-quadruplex DNA binding [GO:0051880]; identical protein binding [GO:0042802]; insulin receptor substrate binding [GO:0043560]; PH domain binding [GO:0042731]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]	membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	GO:0001666; GO:0003697; GO:0003727; GO:0004176; GO:0004252; GO:0005524; GO:0005739; GO:0005759; GO:0006458; GO:0006508; GO:0006515; GO:0007005; GO:0009725; GO:0010044; GO:0016020; GO:0016887; GO:0030163; GO:0034599; GO:0035694; GO:0042645; GO:0042731; GO:0042802; GO:0043531; GO:0043560; GO:0043565; GO:0051131; GO:0051880; GO:0070182; GO:0070407; GO:0140662
GN016865	GN016865.1	Q9H2B2	55.8	301	424	425	1.32e-100	309	SYT4_HUMAN	Synaptotagmin-4 (Synaptotagmin IV) (SytIV)	Homo sapiens (Human)	calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; dense core granule cytoskeletal transport [GO:0099519]; memory [GO:0007613]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of catecholamine secretion [GO:0033604]; negative regulation of protein secretion [GO:0050709]; negative regulation of retrograde trans-synaptic signaling by neuropeptide [GO:1905433]; negative regulation of short-term neuronal synaptic plasticity [GO:0048174]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dense core granule exocytosis [GO:1905415]; positive regulation of glutamate secretion [GO:0014049]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of dopamine secretion [GO:0014059]; regulation of endocytosis [GO:0030100]; regulation of postsynaptic dense core vesicle exocytosis [GO:0150044]; regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0150035]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]	calcium ion binding [GO:0005509]; calcium ion sensor activity [GO:0061891]; calcium-dependent phospholipid binding [GO:0005544]; SNARE binding [GO:0000149]	astrocyte projection [GO:0097449]; axon [GO:0030424]; dendrite [GO:0030425]; dense core granule membrane [GO:0032127]; exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; microvesicle [GO:1990742]; neuronal cell body [GO:0043025]; neuronal dense core vesicle [GO:0098992]; neuronal dense core vesicle membrane [GO:0099012]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]	GO:0000139; GO:0000149; GO:0005509; GO:0005544; GO:0005886; GO:0006906; GO:0007613; GO:0014049; GO:0014059; GO:0016192; GO:0017158; GO:0030100; GO:0030424; GO:0030425; GO:0030672; GO:0032127; GO:0033604; GO:0043025; GO:0045202; GO:0045955; GO:0045956; GO:0048174; GO:0048471; GO:0050709; GO:0061891; GO:0070382; GO:0097449; GO:0098978; GO:0098992; GO:0099012; GO:0099502; GO:0099519; GO:0150035; GO:0150044; GO:1903861; GO:1905415; GO:1905433; GO:1990742; GO:2000301
GN016866	GN016866.1	Q28DG6	34.0	235	286	262	2.08e-25	104	LYSM3_XENTR	LysM and putative peptidoglycan-binding domain-containing protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	Golgi organization [GO:0007030]		Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	GO:0005794; GO:0005886; GO:0007030
GN016867	GN016867.1	Q8R151	30.1	1211	1472	1909	1.16e-141	482	ZNFX1_MOUSE	NFX1-type zinc finger-containing protein 1 (ATP- dependent RNA translocase ZNFX1) (EC 3.6.4.-) (E3 ubiquitin-protein and -ssRNA ligase ZNFX1) (EC 2.3.2.27)	Mus musculus (Mouse)	activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	helicase activity [GO:0004386]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380]	GO:0002218; GO:0003723; GO:0004386; GO:0005741; GO:0005829; GO:0008270; GO:0010494; GO:0031048; GO:0031380; GO:0042742; GO:0045071; GO:0051607; GO:0061630; GO:0140311; GO:1900226
GN016868	GN016868.1	Q9CQS5	51.1	534	488	547	7.31e-159	464	RIOK2_MOUSE	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2)	Mus musculus (Mouse)	maturation of SSU-rRNA [GO:0030490]; positive regulation of ribosomal small subunit export from nucleus [GO:2000208]; positive regulation of rRNA processing [GO:2000234]; protein autophosphorylation [GO:0046777]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ribosomal small subunit biogenesis [GO:0042274]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]	GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0030071; GO:0030490; GO:0030688; GO:0042274; GO:0046777; GO:0106310; GO:2000208; GO:2000234
GN016869	GN016869.1	Q803X0	37.8	482	514	460	3.38e-102	317	SERC5_DANRE	Serine incorporator 5	Danio rerio (Zebrafish) (Brachydanio rerio)	antiviral innate immune response [GO:0140374]; plasma membrane phospholipid scrambling [GO:0017121]	phospholipid scramblase activity [GO:0017128]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0016020; GO:0017121; GO:0017128; GO:0140374
GN016870	GN016870.1	Q8R151	30.0	1211	1472	1909	1.90e-140	478	ZNFX1_MOUSE	NFX1-type zinc finger-containing protein 1 (ATP- dependent RNA translocase ZNFX1) (EC 3.6.4.-) (E3 ubiquitin-protein and -ssRNA ligase ZNFX1) (EC 2.3.2.27)	Mus musculus (Mouse)	activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	helicase activity [GO:0004386]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380]	GO:0002218; GO:0003723; GO:0004386; GO:0005741; GO:0005829; GO:0008270; GO:0010494; GO:0031048; GO:0031380; GO:0042742; GO:0045071; GO:0051607; GO:0061630; GO:0140311; GO:1900226
GN016871	GN016871.1	Q8TEB9	44.1	322	311	315	1.83e-70	224	RHBL4_HUMAN	Rhomboid-related protein 4 (RRP4) (EC 3.4.21.105) (Rhomboid domain-containing protein 1) (Rhomboid-like protein 4)	Homo sapiens (Human)	cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; ERAD pathway [GO:0036503]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein processing [GO:0010954]; positive regulation of secretion [GO:0051047]; post-translational protein modification [GO:0043687]; retrograde protein transport, ER to cytosol [GO:0030970]; spermatid differentiation [GO:0048515]	endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; mitochondrial membrane [GO:0031966]	GO:0004175; GO:0004252; GO:0005783; GO:0005789; GO:0010954; GO:0030970; GO:0031293; GO:0031966; GO:0033619; GO:0034620; GO:0034644; GO:0036503; GO:0043066; GO:0043687; GO:0044322; GO:0045732; GO:0048515; GO:0051047
GN016873	GN016873.1	Q9BVS4	67.9	84	87	552	4.59e-30	114	RIOK2_HUMAN	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2)	Homo sapiens (Human)	maturation of SSU-rRNA [GO:0030490]; positive regulation of ribosomal small subunit export from nucleus [GO:2000208]; positive regulation of rRNA processing [GO:2000234]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ribosomal small subunit biogenesis [GO:0042274]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]	GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0030071; GO:0030490; GO:0030688; GO:0042274; GO:0106310; GO:2000208; GO:2000234
GN016880	GN016880.1	A8VU90	45.7	258	698	534	5.12e-62	219	ANKL1_MOUSE	Structure-specific endonuclease ANKLE1 (Ankyrin repeat and LEM domain-containing protein 1) (EC 3.1.-.-) (Ankyrin repeat domain-containing protein 41) (LEM-domain containing protein 3)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of mitotic recombination [GO:0045950]; protein export from nucleus [GO:0006611]; regulation of lymphoid progenitor cell differentiation [GO:1905456]; regulation of myeloid progenitor cell differentiation [GO:1905453]; resolution of meiotic recombination intermediates [GO:0000712]	cobalt ion binding [GO:0050897]; DNA endonuclease activity [GO:0004520]; endonuclease activity [GO:0004519]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000712; GO:0000724; GO:0004519; GO:0004520; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006611; GO:0006974; GO:0030145; GO:0030496; GO:0045950; GO:0050897; GO:1905453; GO:1905456
GN016903	GN016903.1	H2A0M3	40.0	705	809	781	1.13e-162	494	AMO_PINMG	Putative amine oxidase [copper-containing] (EC 1.4.3.-)	Margaritifera margaritifera (Freshwater pearl mussel)	amine metabolic process [GO:0009308]	copper ion binding [GO:0005507]; primary methylamine oxidase activity [GO:0008131]; quinone binding [GO:0048038]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005507; GO:0005576; GO:0005886; GO:0008131; GO:0009308; GO:0048038
GN016905	GN016905.1	P24367	49.5	190	215	207	5.65e-56	179	PPIB_CHICK	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	Gallus gallus (Chicken)	negative regulation of collagen fibril organization [GO:1904027]; protein folding [GO:0006457]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]; protein-containing complex [GO:0032991]	GO:0003755; GO:0005788; GO:0006457; GO:0016018; GO:0032991; GO:0042470; GO:1904027
GN016906	GN016906.1	Q3T8J9	36.2	210	764	2241	4.21e-26	119	GON4L_HUMAN	GON-4-like protein (GON-4 homolog) (Yin Yang 1-associated-related protein)	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	transcription coregulator activity [GO:0003712]	chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003712; GO:0005634; GO:0005654; GO:0005694; GO:0006355; GO:0016604
GN016907	GN016907.1	Q9VZW5	24.5	318	408	549	2.42e-10	65.9	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN016908	GN016908.1	Q3T8J9	31.3	726	1793	2241	4.14e-56	220	GON4L_HUMAN	GON-4-like protein (GON-4 homolog) (Yin Yang 1-associated-related protein)	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	transcription coregulator activity [GO:0003712]	chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003712; GO:0005634; GO:0005654; GO:0005694; GO:0006355; GO:0016604
GN016909	GN016909.1	P47802	36.8	261	277	317	1.69e-45	158	MTX1_MOUSE	Metaxin-1 (Mitochondrial outer membrane import complex protein 1)	Mus musculus (Mouse)	mitochondrial outer membrane translocase complex assembly [GO:0070096]; protein insertion into mitochondrial outer membrane [GO:0045040]		mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; SAM complex [GO:0001401]	GO:0001401; GO:0005739; GO:0005743; GO:0045040; GO:0070096
GN016910	GN016910.1	Q5U419	38.3	253	250	412	2.22e-39	144	S33A2_MOUSE	Solute carrier family 33 member 2 (Major facilitator superfamily domain-containing protein 3)	Mus musculus (Mouse)		transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0016020; GO:0022857
GN016913	GN016913.1	A8VU90	45.7	258	550	534	2.63e-63	219	ANKL1_MOUSE	Structure-specific endonuclease ANKLE1 (Ankyrin repeat and LEM domain-containing protein 1) (EC 3.1.-.-) (Ankyrin repeat domain-containing protein 41) (LEM-domain containing protein 3)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of mitotic recombination [GO:0045950]; protein export from nucleus [GO:0006611]; regulation of lymphoid progenitor cell differentiation [GO:1905456]; regulation of myeloid progenitor cell differentiation [GO:1905453]; resolution of meiotic recombination intermediates [GO:0000712]	cobalt ion binding [GO:0050897]; DNA endonuclease activity [GO:0004520]; endonuclease activity [GO:0004519]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000712; GO:0000724; GO:0004519; GO:0004520; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006611; GO:0006974; GO:0030145; GO:0030496; GO:0045950; GO:0050897; GO:1905453; GO:1905456
GN016918	GN016918.1	Q96MM6	34.2	632	572	686	1.26e-107	340	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN016919	GN016919.1	Q5VJS5	49.4	314	299	420	6.95e-78	246	DAAF4_RAT	Dynein axonemal assembly factor 4 (Dyslexia susceptibility 1 candidate gene 1 protein homolog)	Rattus norvegicus (Rat)	cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; heart development [GO:0007507]; inner dynein arm assembly [GO:0036159]; learning or memory [GO:0007611]; neuron migration [GO:0001764]; outer dynein arm assembly [GO:0036158]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of proteasomal protein catabolic process [GO:0061136]	nuclear estrogen receptor binding [GO:0030331]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular region [GO:0005576]; neuron projection [GO:0043005]; non-motile cilium [GO:0097730]; nucleus [GO:0005634]	GO:0001764; GO:0003341; GO:0003351; GO:0005576; GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0007368; GO:0007507; GO:0007611; GO:0030331; GO:0033146; GO:0036158; GO:0036159; GO:0043005; GO:0061136; GO:0097730; GO:0120293
GN016920	GN016920.1	P31795	38.7	111	214	581	1.15e-16	81.3	POL_MLVRK	Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]	Radiation murine leukemia virus (strain Kaplan)	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; symbiont entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826]	nucleic acid binding [GO:0003676]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]		GO:0003676; GO:0003964; GO:0004523; GO:0006310; GO:0015074; GO:0044826; GO:0046718; GO:0075713
GN016921	GN016921.1	O44252	26.6	256	304	275	2.80e-22	97.1	ROST_DROME	Protein rolling stone	Drosophila melanogaster (Fruit fly)	myoblast fusion [GO:0007520]		membrane [GO:0016020]	GO:0007520; GO:0016020
GN016922	GN016922.1	P24668	35.4	130	150	278	1.02e-09	58.5	MPRD_MOUSE	Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)	Mus musculus (Mouse)	Golgi to lysosome transport [GO:0090160]; intracellular protein transport [GO:0006886]; lysosomal transport [GO:0007041]; protein targeting to lysosome [GO:0006622]; secretion of lysosomal enzymes [GO:0033299]	cargo receptor activity [GO:0038024]; protein domain specific binding [GO:0019904]; retromer complex binding [GO:1905394]	cytosol [GO:0005829]; endosome [GO:0005768]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802]	GO:0005765; GO:0005768; GO:0005770; GO:0005802; GO:0005829; GO:0006622; GO:0006886; GO:0007041; GO:0019904; GO:0033299; GO:0038024; GO:0048471; GO:0090160; GO:1905394
GN016923	GN016923.1	A7FH13	22.8	394	412	371	1.57e-11	68.9	MTOX_YERP3	N-methyl-L-tryptophan oxidase (MTOX) (EC 1.5.3.-)	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)		flavin adenine dinucleotide binding [GO:0050660]; N-methyl-L-amino-acid oxidase activity [GO:0050131]; sarcosine oxidase activity [GO:0008115]	cytosol [GO:0005829]	GO:0005829; GO:0008115; GO:0050131; GO:0050660
GN016924	GN016924.1	Q9P2E3	36.5	1196	2383	1918	8.60e-203	671	ZNFX1_HUMAN	NFX1-type zinc finger-containing protein 1 (ATP- dependent RNA translocase ZNFX1) (EC 3.6.4.-) (E3 ubiquitin-protein and -ssRNA ligase ZNFX1) (EC 2.3.2.27)	Homo sapiens (Human)	activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	helicase activity [GO:0004386]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380]	GO:0002218; GO:0003723; GO:0004386; GO:0005741; GO:0005829; GO:0008270; GO:0010494; GO:0031048; GO:0031380; GO:0042742; GO:0045071; GO:0051607; GO:0061630; GO:0140311; GO:1900226
GN016925	GN016925.1	Q9P2E3	36.0	1094	2325	1918	2.64e-178	601	ZNFX1_HUMAN	NFX1-type zinc finger-containing protein 1 (ATP- dependent RNA translocase ZNFX1) (EC 3.6.4.-) (E3 ubiquitin-protein and -ssRNA ligase ZNFX1) (EC 2.3.2.27)	Homo sapiens (Human)	activation of innate immune response [GO:0002218]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; negative regulation of viral genome replication [GO:0045071]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]	helicase activity [GO:0004386]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial outer membrane [GO:0005741]; nuclear RNA-directed RNA polymerase complex [GO:0031380]	GO:0002218; GO:0003723; GO:0004386; GO:0005741; GO:0005829; GO:0008270; GO:0010494; GO:0031048; GO:0031380; GO:0042742; GO:0045071; GO:0051607; GO:0061630; GO:0140311; GO:1900226
GN016926	GN016926.1	A0A250YGJ5	64.5	279	448	355	1.34e-129	381	SIR6_CASCN	NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-)	Castor canadensis (American beaver)	cardiac muscle cell differentiation [GO:0055007]; circadian regulation of gene expression [GO:0032922]; determination of adult lifespan [GO:0008340]; double-strand break repair [GO:0006302]; ketone biosynthetic process [GO:0042181]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of glycolytic process [GO:0045820]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; pericentric heterochromatin formation [GO:0031508]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein localization to chromatin [GO:0120187]; positive regulation of stem cell differentiation [GO:2000738]; protein delipidation [GO:0051697]; protein destabilization [GO:0031648]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of lipid catabolic process [GO:0050994]; regulation of lipid metabolic process [GO:0019216]; transposable element silencing [GO:0010526]	chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA damage sensor activity [GO:0140612]; histone H3K18 deacetylase activity, NAD-dependent [GO:0097372]; histone H3K56 deacetylase activity, NAD-dependent [GO:0140765]; histone H3K9 deacetylase activity, NAD-dependent [GO:0046969]; NAD+ binding [GO:0070403]; NAD+-protein-arginine ADP-ribosyltransferase activity [GO:0106274]; NAD+-protein-lysine ADP-ribosyltransferase activity [GO:0140804]; NAD-dependent protein demyristoylase activity [GO:0140773]; NAD-dependent protein depalmitoylase activity [GO:0140774]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; nucleosome binding [GO:0031491]; protein homodimerization activity [GO:0042803]; TORC2 complex binding [GO:1904841]; transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	GO:0000122; GO:0000781; GO:0000785; GO:0003684; GO:0003714; GO:0005634; GO:0005694; GO:0005783; GO:0006302; GO:0008340; GO:0010526; GO:0010569; GO:0019216; GO:0031490; GO:0031491; GO:0031508; GO:0031648; GO:0032024; GO:0032922; GO:0034244; GO:0034979; GO:0042181; GO:0042308; GO:0042752; GO:0042803; GO:0045600; GO:0045721; GO:0045820; GO:0046827; GO:0046969; GO:0050994; GO:0051697; GO:0055007; GO:0070403; GO:0097372; GO:0106274; GO:0120162; GO:0120187; GO:0140612; GO:0140765; GO:0140773; GO:0140774; GO:0140804; GO:1904841; GO:2000738; GO:2000781
GN016927	GN016927.1	O14522	42.9	63	92	1441	1.15e-09	56.6	PTPRT_HUMAN	Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho)	Homo sapiens (Human)	cell adhesion [GO:0007155]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to interleukin-6 [GO:0071354]; homophilic cell-cell adhesion [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	alpha-actinin binding [GO:0051393]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine phosphatase activity [GO:0004725]; STAT family protein binding [GO:0097677]; thiolester hydrolase activity [GO:0016790]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004725; GO:0005001; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016020; GO:0016790; GO:0019903; GO:0030336; GO:0031175; GO:0042803; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097; GO:0071354; GO:0097677; GO:1904893
GN016929	GN016929.1	Q3UMB5	28.8	312	665	935	3.73e-26	118	SMCR8_MOUSE	Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog)	Mus musculus (Mouse)	negative regulation of autophagosome assembly [GO:1902902]; negative regulation of exocytosis [GO:0045920]; negative regulation of gene expression [GO:0010629]; negative regulation of immune response [GO:0050777]; negative regulation of macroautophagy [GO:0016242]; positive regulation of autophagosome maturation [GO:1901098]; positive regulation of TOR signaling [GO:0032008]; regulation of autophagy [GO:0010506]; regulation of TORC1 signaling [GO:1903432]	GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]	Atg1/ULK1 kinase complex [GO:1990316]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor complex [GO:0032045]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; presynapse [GO:0098793]	GO:0000785; GO:0004860; GO:0005085; GO:0005096; GO:0005634; GO:0005654; GO:0005737; GO:0010506; GO:0010629; GO:0016242; GO:0019901; GO:0032008; GO:0032045; GO:0045920; GO:0050777; GO:0098793; GO:0098794; GO:1901098; GO:1902902; GO:1903432; GO:1990316
GN016934	GN016934.1	Q9NZJ4	27.1	4700	4294	4579	0.0	1259	SACS_HUMAN	Sacsin (DnaJ homolog subfamily C member 29)	Homo sapiens (Human)	negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0070852; GO:0090084
GN016936	GN016936.1	Q9JLC8	26.4	4653	4321	4582	0.0	1222	SACS_MOUSE	Sacsin (DnaJ homolog subfamily C member 29)	Mus musculus (Mouse)	negative regulation of inclusion body assembly [GO:0090084]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0090084
GN016939	GN016939.1	Q9NZJ4	24.3	1517	1451	4579	8.38e-82	302	SACS_HUMAN	Sacsin (DnaJ homolog subfamily C member 29)	Homo sapiens (Human)	negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0070852; GO:0090084
GN016940	GN016940.1	Q9NZJ4	29.5	2704	2528	4579	1.66e-264	880	SACS_HUMAN	Sacsin (DnaJ homolog subfamily C member 29)	Homo sapiens (Human)	negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0070852; GO:0090084
GN016941	GN016941.1	Q0IIF9	28.5	491	475	543	1.74e-52	188	CP2U1_BOVIN	Cytochrome P450 2U1 (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)	Bos taurus (Bovine)	steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	arachidonate omega-hydroxylase activity [GO:0052869]; fatty acid omega-1 hydroxylase activity [GO:0120502]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]	GO:0005506; GO:0005737; GO:0005743; GO:0005789; GO:0006805; GO:0008202; GO:0008395; GO:0016712; GO:0020037; GO:0052869; GO:0102033; GO:0120502
GN016942	GN016942.1	Q8K4Q8	36.6	112	119	742	1.89e-13	68.6	COL12_MOUSE	Collectin-12 (Collectin placenta protein 1) (CL-P1) (Scavenger receptor with C-type lectin)	Mus musculus (Mouse)	defense response to bacterium [GO:0042742]; immune response [GO:0006955]; phagocytosis, recognition [GO:0006910]	carbohydrate binding [GO:0030246]; low-density lipoprotein particle binding [GO:0030169]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]	extracellular matrix [GO:0031012]; membrane [GO:0016020]	GO:0005044; GO:0006910; GO:0006955; GO:0016020; GO:0030169; GO:0030246; GO:0031012; GO:0038187; GO:0042742
GN016943	GN016943.1	Q8IUN9	35.8	81	83	316	5.53e-11	59.7	CLC10_HUMAN	C-type lectin domain family 10 member A (C-type lectin superfamily member 14) (DC-asialoglycoprotein receptor) (DC-ASGPR) (Macrophage galactose-type lectin) (MGL) (Macrophage lectin 2) (CD antigen CD301)	Homo sapiens (Human)	immune response [GO:0006955]	carbohydrate binding [GO:0030246]; D-mannose binding [GO:0005537]; fucose binding [GO:0042806]; pattern recognition receptor activity [GO:0038187]	early endosome membrane [GO:0031901]; external side of plasma membrane [GO:0009897]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	GO:0005537; GO:0005765; GO:0005886; GO:0006955; GO:0009897; GO:0030246; GO:0031901; GO:0038187; GO:0042806
GN016944	GN016944.1	Q9NS73	39.8	201	279	344	5.39e-30	118	MBIP1_HUMAN	MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of DNA-templated transcription [GO:0006355]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tubulin deacetylation [GO:0090043]	identical protein binding [GO:0042802]; protein kinase inhibitor activity [GO:0004860]	ATAC complex [GO:0140672]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitotic spindle [GO:0072686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0004860; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006355; GO:0006357; GO:0010628; GO:0042802; GO:0045995; GO:0046330; GO:0051302; GO:0051726; GO:0072686; GO:0090043; GO:0140672
GN016945	GN016945.1	Q6NRG0	26.9	454	629	532	2.21e-31	132	RNF8B_XENLA	E3 ubiquitin-protein ligase rnf8-B (EC 2.3.2.27) (RING finger protein 8-B) (RING-type E3 ubiquitin transferase rnf8-B)	Xenopus laevis (African clawed frog)	DNA damage response [GO:0006974]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; epigenetic regulation of gene expression [GO:0040029]; isotype switching [GO:0045190]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; response to ionizing radiation [GO:0010212]; sperm DNA condensation [GO:0035092]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; protein homodimerization activity [GO:0042803]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000781; GO:0003682; GO:0005634; GO:0005829; GO:0006302; GO:0006303; GO:0006511; GO:0006974; GO:0008270; GO:0010212; GO:0034244; GO:0035092; GO:0035861; GO:0040029; GO:0042393; GO:0042803; GO:0043130; GO:0045190; GO:0045739; GO:0061630; GO:0070534; GO:0070936; GO:0085020; GO:0140861; GO:1905168
GN016947	GN016947.1	P30044	60.0	155	157	214	1.01e-62	194	PRDX5_HUMAN	Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5)	Homo sapiens (Human)	cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; hydrogen peroxide catabolic process [GO:0042744]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of transcription by RNA polymerase III [GO:0016480]; positive regulation of collagen biosynthetic process [GO:0032967]; reactive nitrogen species metabolic process [GO:2001057]; regulation of apoptosis involved in tissue homeostasis [GO:0060785]; response to oxidative stress [GO:0006979]	antioxidant activity [GO:0016209]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; peroxidase activity [GO:0004601]; peroxynitrite reductase activity [GO:0072541]; RNA polymerase III transcription regulatory region sequence-specific DNA binding [GO:0001016]; signaling receptor binding [GO:0005102]; thioredoxin peroxidase activity [GO:0008379]; thioredoxin-dependent peroxiredoxin activity [GO:0140824]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0001016; GO:0004601; GO:0005102; GO:0005576; GO:0005634; GO:0005737; GO:0005739; GO:0005759; GO:0005777; GO:0005782; GO:0005829; GO:0006954; GO:0006979; GO:0008379; GO:0016209; GO:0016480; GO:0031410; GO:0032967; GO:0034599; GO:0034614; GO:0042744; GO:0042802; GO:0043027; GO:0043066; GO:0043231; GO:0045454; GO:0048471; GO:0051354; GO:0060785; GO:0070062; GO:0072541; GO:0140824; GO:2001057
GN016948	GN016948.1	Q07889	55.1	1057	1213	1333	0.0	1077	SOS1_HUMAN	Son of sevenless homolog 1 (SOS-1)	Homo sapiens (Human)	axon guidance [GO:0007411]; B cell receptor signaling pathway [GO:0050853]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc-epsilon receptor signaling pathway [GO:0038095]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; leukocyte migration [GO:0050900]; myelination [GO:0042552]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of Rac protein signal transduction [GO:0035022]; Ras protein signal transduction [GO:0007265]; regulation of cell population proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ischemia [GO:0002931]; Schwann cell development [GO:0014044]; signal transduction [GO:0007165]; T cell activation [GO:0042110]	epidermal growth factor receptor binding [GO:0005154]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; molecular condensate scaffold activity [GO:0140693]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; GTPase complex [GO:1905360]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	GO:0002931; GO:0005085; GO:0005096; GO:0005154; GO:0005737; GO:0005829; GO:0005886; GO:0006357; GO:0007165; GO:0007173; GO:0007265; GO:0007411; GO:0008286; GO:0014044; GO:0014069; GO:0017124; GO:0019221; GO:0019901; GO:0035022; GO:0038095; GO:0042110; GO:0042127; GO:0042552; GO:0043025; GO:0045742; GO:0046982; GO:0048009; GO:0048011; GO:0050853; GO:0050900; GO:0098978; GO:0140693; GO:1905360
GN016949	GN016949.1	Q96BJ3	46.5	303	298	306	5.55e-83	255	AIDA_HUMAN	Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist)	Homo sapiens (Human)	determination of ventral identity [GO:0048264]; dorsal/ventral pattern formation [GO:0009953]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of protein-containing complex assembly [GO:0031333]	phosphatidylinositol binding [GO:0035091]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0005737; GO:0009953; GO:0016020; GO:0019904; GO:0031333; GO:0035091; GO:0043508; GO:0046329; GO:0048264
GN016950	GN016950.1	Q4KMC9	32.0	175	370	330	3.50e-18	87.8	CA198_DANRE	Uncharacterized protein C1orf198 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)				
GN016951	GN016951.1	Q80XC6	29.3	1059	1027	1172	6.91e-117	390	NRDE2_MOUSE	Nuclear exosome regulator NRDE2 (Protein NRDE2 homolog)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; mitotic cell cycle [GO:0000278]; mRNA stabilization [GO:0048255]; negative regulation of RNA catabolic process [GO:1902369]; positive regulation of RNA export from nucleus [GO:0046833]; regulatory ncRNA-mediated heterochromatin formation [GO:0031048]; RNA splicing [GO:0008380]		mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000278; GO:0005634; GO:0005654; GO:0005730; GO:0005739; GO:0006974; GO:0008380; GO:0016607; GO:0031048; GO:0046833; GO:0048255; GO:1902369
GN016952	GN016952.1	Q9JLC8	25.3	3980	3671	4582	1.25e-279	948	SACS_MOUSE	Sacsin (DnaJ homolog subfamily C member 29)	Mus musculus (Mouse)	negative regulation of inclusion body assembly [GO:0090084]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0090084
GN016953	GN016953.1	Q9NZJ4	23.3	965	879	4579	4.35e-34	145	SACS_HUMAN	Sacsin (DnaJ homolog subfamily C member 29)	Homo sapiens (Human)	negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	axon [GO:0030424]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0070852; GO:0090084
GN016954	GN016954.1	Q9JLC8	26.5	2852	2693	4582	2.74e-235	796	SACS_MOUSE	Sacsin (DnaJ homolog subfamily C member 29)	Mus musculus (Mouse)	negative regulation of inclusion body assembly [GO:0090084]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0090084
GN016955	GN016955.1	Q9JLC8	29.6	348	366	4582	2.23e-34	138	SACS_MOUSE	Sacsin (DnaJ homolog subfamily C member 29)	Mus musculus (Mouse)	negative regulation of inclusion body assembly [GO:0090084]	Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; low-density lipoprotein particle receptor binding [GO:0050750]; proteasome binding [GO:0070628]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005739; GO:0030544; GO:0042802; GO:0050750; GO:0051087; GO:0070628; GO:0090084
GN016957	GN016957.1	Q0E908	25.2	460	705	818	2.05e-30	131	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN016958	GN016958.1	Q0E908	26.0	366	521	818	1.04e-25	115	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN016961	GN016961.1	Q149M9	30.9	940	1741	1564	1.72e-102	367	NWD1_HUMAN	NACHT domain- and WD repeat-containing protein 1	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]		cytosol [GO:0005829]	GO:0005829; GO:0035556
GN016963	GN016963.1	Q8NBH2	29.0	238	378	661	9.05e-29	121	KY_HUMAN	Kyphoscoliosis peptidase (EC 3.4.-.-)	Homo sapiens (Human)	muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]	GO:0005737; GO:0005856; GO:0007517; GO:0007528; GO:0030018
GN016966	GN016966.1	E7FAM5	28.5	130	573	824	5.85e-09	62.8	LIN41_DANRE	E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)	Danio rerio (Zebrafish) (Brachydanio rerio)	fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; post-transcriptional regulation of gene expression [GO:0010608]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]	miRNA binding [GO:0035198]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	P-body [GO:0000932]	GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010608; GO:0021915; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
GN016968	GN016968.1	E7FAM5	28.5	130	573	824	5.85e-09	62.8	LIN41_DANRE	E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)	Danio rerio (Zebrafish) (Brachydanio rerio)	fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; post-transcriptional regulation of gene expression [GO:0010608]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]	miRNA binding [GO:0035198]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	P-body [GO:0000932]	GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010608; GO:0021915; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
GN016969	GN016969.1	Q7TNC6	57.6	517	1702	2112	1.89e-159	540	KI26B_MOUSE	Kinesin-like protein KIF26B	Mus musculus (Mouse)	establishment of cell polarity [GO:0030010]; microtubule-based movement [GO:0007018]; positive regulation of cell-cell adhesion [GO:0022409]; ureteric bud invasion [GO:0072092]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	GO:0003777; GO:0005524; GO:0005737; GO:0005856; GO:0007018; GO:0008017; GO:0022409; GO:0030010; GO:0072092
GN016970	GN016970.1	Q8VE92	53.0	100	234	357	9.92e-32	122	RBM4B_MOUSE	RNA-binding protein 4B (RNA-binding motif protein 30) (RNA-binding motif protein 4B) (RNA-binding protein 30)	Mus musculus (Mouse)	circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; positive regulation of gene expression [GO:0010628]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of translation [GO:0006417]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	GO:0000381; GO:0003723; GO:0005654; GO:0005730; GO:0005829; GO:0006417; GO:0007623; GO:0008270; GO:0010628; GO:0032922; GO:0032991; GO:0043153
GN016971	GN016971.1	P30437	26.8	332	341	514	9.16e-22	99.4	CP17A_ONCMY	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)	Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid biosynthetic process [GO:0006694]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	membrane [GO:0016020]	GO:0004508; GO:0005506; GO:0006694; GO:0016020; GO:0020037; GO:0042446; GO:0042448
GN016976	GN016976.1	Q9UNH7	65.9	405	406	406	2.98e-184	520	SNX6_HUMAN	Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed]	Homo sapiens (Human)	cellular response to amyloid-beta [GO:1904646]; cellular response to epidermal growth factor stimulus [GO:0071364]; intracellular protein transport [GO:0006886]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of macroautophagy [GO:0016241]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; retrograde transport, endosome to Golgi [GO:0042147]	dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091]; protein homodimerization activity [GO:0042803]; type I transforming growth factor beta receptor binding [GO:0034713]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; lysosome [GO:0005764]; nucleus [GO:0005634]; postsynaptic early endosome [GO:0098842]; retromer complex [GO:0030904]; retromer, tubulation complex [GO:0030905]; tubular endosome [GO:0097422]	GO:0005634; GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005829; GO:0006886; GO:0007175; GO:0016241; GO:0030512; GO:0030904; GO:0030905; GO:0031410; GO:0031901; GO:0034452; GO:0034713; GO:0035091; GO:0042147; GO:0042803; GO:0043524; GO:0045892; GO:0071364; GO:0097422; GO:0098842; GO:0098978; GO:0099072; GO:1904646
GN016979	GN016979.1	Q0IHH1	82.6	149	319	273	2.97e-80	248	NAA30_XENLA	N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit)	Xenopus laevis (African clawed frog)	protein stabilization [GO:0050821]	protein N-terminal-methionine acetyltransferase activity [GO:0120518]; protein-N-terminal amino-acid acetyltransferase activity [GO:0004596]	cytoplasm [GO:0005737]; NatC complex [GO:0031417]; nucleus [GO:0005634]	GO:0004596; GO:0005634; GO:0005737; GO:0031417; GO:0050821; GO:0120518
GN016980	GN016980.1	Q5XK91	46.0	224	1157	457	1.52e-58	212	FBCDB_XENLA	Fibrinogen C domain-containing protein 1-B	Xenopus laevis (African clawed frog)			extracellular matrix [GO:0031012]; membrane [GO:0016020]	GO:0016020; GO:0031012
GN016984	GN016984.1	P42620	57.4	312	327	328	4.26e-123	359	YQJG_ECOLI	Glutathionyl-hydroquinone reductase YqjG (GS-HQR) (EC 1.8.5.7)	Escherichia coli (strain K12)		glutathione transferase activity [GO:0004364]; oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [GO:0016672]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]	GO:0004364; GO:0005737; GO:0016672; GO:0042803
GN016985	GN016985.1	Q6TDP3	33.0	212	681	640	8.91e-25	113	KLH17_MOUSE	Kelch-like protein 17 (Actinfilin)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]	actin filament binding [GO:0051015]; molecular adaptor activity [GO:0060090]; POZ domain binding [GO:0031208]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	actin cytoskeleton [GO:0015629]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	GO:0005737; GO:0014069; GO:0015629; GO:0016567; GO:0030036; GO:0031208; GO:0031463; GO:0032839; GO:0043025; GO:0043161; GO:0045202; GO:0051015; GO:0060090; GO:0098794; GO:0098978; GO:0140252; GO:1990756
GN016986	GN016986.1	Q501P1	41.7	84	449	440	2.58e-13	75.1	FBLN7_MOUSE	Fibulin-7 (FIBL-7) (Protein TM14)	Mus musculus (Mouse)		calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]	GO:0005509; GO:0005576; GO:0008201; GO:0031012; GO:0043395; GO:0140144
GN016987	GN016987.1	Q4LDE5	25.1	725	2957	3571	3.68e-37	159	SVEP1_HUMAN	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)	Homo sapiens (Human)	epidermis development [GO:0008544]; lymph vessel morphogenesis [GO:0036303]; negative regulation of vasoconstriction [GO:0045906]; positive regulation of platelet activation [GO:0010572]	calcium ion binding [GO:0005509]; chromatin binding [GO:0003682]; integrin binding [GO:0005178]; integrin binding involved in cell-matrix adhesion [GO:0098640]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0003682; GO:0005178; GO:0005509; GO:0005576; GO:0005634; GO:0005737; GO:0008544; GO:0010572; GO:0016020; GO:0036303; GO:0045906; GO:0098640
GN016988	GN016988.1	Q501P1	40.5	84	365	440	1.04e-13	75.5	FBLN7_MOUSE	Fibulin-7 (FIBL-7) (Protein TM14)	Mus musculus (Mouse)		calcium ion binding [GO:0005509]; heparan sulfate proteoglycan binding [GO:0043395]; heparin binding [GO:0008201]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]	GO:0005509; GO:0005576; GO:0008201; GO:0031012; GO:0043395; GO:0140144
GN016989	GN016989.1	P16554	54.6	357	538	556	1.02e-108	338	NUMB_DROME	Protein numb	Drosophila melanogaster (Fruit fly)	asymmetric neuroblast division [GO:0055059]; centrosome localization [GO:0051642]; embryonic heart tube development [GO:0035050]; enteroendocrine cell differentiation [GO:0035883]; glial cell migration [GO:0008347]; intracellular protein localization [GO:0008104]; Malpighian tubule tip cell differentiation [GO:0061382]; muscle cell fate specification [GO:0042694]; negative regulation of gene expression [GO:0010629]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of receptor recycling [GO:0001920]; neuroblast development [GO:0014019]; neuroblast proliferation [GO:0007405]; pericardial nephrocyte differentiation [GO:0061320]; positive regulation of endocytosis [GO:0045807]; regulation of asymmetric cell division [GO:0009786]; regulation of nervous system development [GO:0051960]; regulation of neuroblast proliferation [GO:1902692]; regulation of neurogenesis [GO:0050767]; sensory organ precursor cell division [GO:0045035]; sensory organ precursor cell fate determination [GO:0016360]	Notch binding [GO:0005112]	basal part of cell [GO:0045178]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001920; GO:0005112; GO:0005634; GO:0005737; GO:0005938; GO:0007405; GO:0007406; GO:0008104; GO:0008347; GO:0009786; GO:0010629; GO:0014019; GO:0016360; GO:0035050; GO:0035883; GO:0042694; GO:0045035; GO:0045178; GO:0045746; GO:0045807; GO:0050767; GO:0051642; GO:0051960; GO:0055059; GO:0061320; GO:0061382; GO:1902692
GN016990	GN016990.1	Q5ZIL9	41.6	584	581	594	9.23e-139	418	KBP_CHICK	KIF-binding protein (KIF1-binding protein)	Gallus gallus (Chicken)	central nervous system projection neuron axonogenesis [GO:0021952]; microtubule cytoskeleton organization [GO:0000226]; mitochondrion transport along microtubule [GO:0047497]; neuron projection maintenance [GO:1990535]	kinesin binding [GO:0019894]; protein sequestering activity [GO:0140311]	cytoskeleton [GO:0005856]	GO:0000226; GO:0005856; GO:0019894; GO:0021952; GO:0047497; GO:0140311; GO:1990535
GN016991	GN016991.1	Q7M456	69.2	211	242	213	1.24e-118	340	RNOY_MAGGI	Ribonuclease Oy (RNase Oy) (EC 3.1.27.-)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	RNA catabolic process [GO:0006401]	ribonuclease T2 activity [GO:0033897]; RNA binding [GO:0003723]	extracellular region [GO:0005576]	GO:0003723; GO:0005576; GO:0006401; GO:0033897
GN016992	GN016992.1	Q9BWU0	41.3	666	742	742	2.37e-128	402	NADAP_HUMAN	Kanadaptin (Human lung cancer oncogene 3 protein) (HLC-3) (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein)	Homo sapiens (Human)		mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0003729; GO:0005654; GO:0005737
GN016993	GN016993.1	P29691	75.9	715	717	852	0.0	1117	EF2_CAEEL	Elongation factor 2 (EF-2) (EC 3.6.5.-)	Caenorhabditis elegans	defense response to Gram-negative bacterium [GO:0050829]; negative regulation of gene expression [GO:0010629]; translational elongation [GO:0006414]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]	GO:0003746; GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0006414; GO:0010629; GO:0043022; GO:0050829; GO:1990904
GN016998	GN016998.1	P28668	53.2	1735	1614	1714	0.0	1698	SYEP_DROME	Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)]	Drosophila melanogaster (Fruit fly)	glutamyl-tRNA aminoacylation [GO:0006424]; prolyl-tRNA aminoacylation [GO:0006433]	ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; proline-tRNA ligase activity [GO:0004827]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]	GO:0004818; GO:0004827; GO:0005524; GO:0005737; GO:0006424; GO:0006433; GO:0017101
GN016999	GN016999.1	Q96Q07	61.4	572	626	612	6.56e-267	747	BTBD9_HUMAN	BTB/POZ domain-containing protein 9	Homo sapiens (Human)	adult locomotory behavior [GO:0008344]; circadian behavior [GO:0048512]; modulation of chemical synaptic transmission [GO:0050804]		cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]	GO:0005737; GO:0008344; GO:0048512; GO:0050804; GO:0098978
GN017000	GN017000.1	Q2YDP3	71.4	98	382	205	1.31e-36	135	NC2A_BOVIN	Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha)	Bos taurus (Bovine)	negative regulation of transcription by RNA polymerase II [GO:0000122]; transcription by RNA polymerase II [GO:0006366]	core promoter sequence-specific DNA binding [GO:0001046]; protein heterodimerization activity [GO:0046982]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	negative cofactor 2 complex [GO:0017054]	GO:0000122; GO:0001046; GO:0006366; GO:0016251; GO:0017054; GO:0046982
GN017001	GN017001.1	P53569	40.0	1019	1002	1052	4.93e-203	614	CEBPZ_MOUSE	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor)	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]	transcription coactivator activity [GO:0003713]	CCAAT-binding factor complex [GO:0016602]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005654; GO:0016602; GO:0045944
GN017002	GN017002.1	Q3MHQ7	31.8	223	235	240	1.61e-23	97.8	TM86A_BOVIN	Lysoplasmalogenase TMEM86A (EC 3.3.2.2) (Transmembrane protein 86A)	Bos taurus (Bovine)		alkenylglycerophosphocholine hydrolase activity [GO:0047408]; hydrolase activity [GO:0016787]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0005789; GO:0016020; GO:0016787; GO:0047408
GN017003	GN017003.1	P0DMQ6	61.7	342	346	355	2.14e-156	445	DHSO_CHICK	Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) (Polyol dehydrogenase)	Gallus gallus (Chicken)	D-sorbitol biosynthetic process [GO:0006061]; D-sorbitol catabolic process [GO:0006062]; fructose biosynthetic process [GO:0046370]; fructose metabolic process [GO:0006000]	L-iditol 2-dehydrogenase (NAD+) activity [GO:0003939]; NAD binding [GO:0051287]; zinc ion binding [GO:0008270]	mitochondrial membrane [GO:0031966]; motile cilium [GO:0031514]; protein-containing complex [GO:0032991]	GO:0003939; GO:0006000; GO:0006061; GO:0006062; GO:0008270; GO:0031514; GO:0031966; GO:0032991; GO:0046370; GO:0051287
GN017004	GN017004.1	P11048	38.3	486	513	665	2.58e-78	261	LMNA_XENLA	Lamin-A	Xenopus laevis (African clawed frog)	heterochromatin formation [GO:0031507]; nuclear envelope organization [GO:0006998]; nuclear migration [GO:0007097]; nuclear pore localization [GO:0051664]; protein localization to nuclear envelope [GO:0090435]	structural constituent of cytoskeleton [GO:0005200]	nuclear envelope [GO:0005635]; nuclear lamina [GO:0005652]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]	GO:0005200; GO:0005635; GO:0005652; GO:0005654; GO:0006998; GO:0007097; GO:0016363; GO:0031507; GO:0051664; GO:0090435
GN017006	GN017006.1	O88801	52.4	229	631	354	2.71e-58	202	HOME2_RAT	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up-regulated during seizure and LTP 2) (Vesl-2)	Rattus norvegicus (Rat)	behavioral response to cocaine [GO:0048148]; calcium-mediated signaling [GO:0019722]; cellular response to L-glutamate [GO:1905232]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of interleukin-2 production [GO:0032703]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of glutamate secretion [GO:0014048]; regulation of store-operated calcium entry [GO:2001256]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to cocaine [GO:0042220]; response to ethanol [GO:0045471]; sensory perception of sound [GO:0007605]	actin binding [GO:0003779]; G protein-coupled glutamate receptor binding [GO:0035256]; glutamate receptor binding [GO:0035254]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; synaptic receptor adaptor activity [GO:0030160]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; stereocilium tip [GO:0032426]	GO:0003779; GO:0005737; GO:0005829; GO:0005886; GO:0007216; GO:0007605; GO:0008277; GO:0014048; GO:0014069; GO:0019722; GO:0019904; GO:0030160; GO:0030425; GO:0032426; GO:0032703; GO:0035254; GO:0035256; GO:0042220; GO:0042802; GO:0043025; GO:0044877; GO:0045177; GO:0045471; GO:0048148; GO:0051966; GO:0070885; GO:0098978; GO:1905232; GO:2001256
GN017007	GN017007.1	O15945	44.8	538	486	642	1.05e-115	357	ARNT_DROME	Aryl hydrocarbon receptor nuclear translocator homolog (dARNT) (Hypoxia-inducible factor 1-beta) (Protein tango)	Drosophila melanogaster (Fruit fly)	appendage development [GO:0048736]; brain development [GO:0007420]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; central nervous system development [GO:0007417]; glial cell migration [GO:0008347]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; insulin receptor signaling pathway [GO:0008286]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oogenesis [GO:0048477]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of R7 cell differentiation [GO:0045676]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; myosin binding [GO:0017022]; protein heterodimerization activity [GO:0046982]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	aryl hydrocarbon receptor complex [GO:0034751]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000122; GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0005634; GO:0005737; GO:0006355; GO:0006357; GO:0007417; GO:0007420; GO:0008286; GO:0008347; GO:0016348; GO:0017022; GO:0032869; GO:0032991; GO:0034751; GO:0043565; GO:0045676; GO:0045944; GO:0046982; GO:0048477; GO:0048736; GO:0071456; GO:0090575
GN017008	GN017008.1	Q21565	45.0	387	517	687	1.10e-105	333	AMT3_CAEEL	Putative ammonium transporter 3	Caenorhabditis elegans	ammonium homeostasis [GO:0097272]	ammonium channel activity [GO:0008519]	membrane [GO:0016020]	GO:0008519; GO:0016020; GO:0097272
GN017009	GN017009.1	H2FLJ1	69.3	287	342	324	1.74e-115	340	STML1_CAEEL	Stomatin-like protein stl-1	Caenorhabditis elegans	mitochondrion organization [GO:0007005]		membrane raft [GO:0045121]; mitochondrion [GO:0005739]	GO:0005739; GO:0007005; GO:0045121
GN017011	GN017011.1	C0HBB2	29.5	390	435	406	7.53e-42	155	GLMP_SALSA	Glycosylated lysosomal membrane protein (Lysosomal protein NCU-G1)	Salmo salar (Atlantic salmon)	protein localization to lysosome [GO:0061462]; protein stabilization [GO:0050821]		lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]	GO:0005764; GO:0005765; GO:0016020; GO:0050821; GO:0061462
GN017012	GN017012.1	Q3U1D0	28.3	184	579	764	5.09e-14	79.0	LINES_MOUSE	Protein Lines homolog 1 (Protein Lines homolog 2) (Wnt-signaling molecule Lines homolog 1)	Mus musculus (Mouse)	cognition [GO:0050890]			GO:0050890
GN017013	GN017013.1	Q6PUR6	67.0	288	299	311	9.74e-142	404	GPN2_DANRE	GPN-loop GTPase 2 (EC 3.6.5.-) (ATP-binding domain 1 family member B)	Danio rerio (Zebrafish) (Brachydanio rerio)		GTPase activity [GO:0003924]	cytoplasm [GO:0005737]	GO:0003924; GO:0005737
GN017014	GN017014.1	P86786	26.2	202	563	284	4.93e-14	76.3	GIGA3_MAGGI	Gigasin-3a	Magallana gigas (Pacific oyster) (Crassostrea gigas)				
GN017015	GN017015.1	Q3ZCK9	84.5	226	268	261	6.74e-134	381	PSA4_BOVIN	Proteasome subunit alpha type-4	Bos taurus (Bovine)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]	GO:0000932; GO:0005634; GO:0005737; GO:0005829; GO:0005839; GO:0019773; GO:0043161
GN017016	GN017016.1	P50904	47.4	570	637	1038	9.58e-163	496	RASA1_RAT	Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)	Rattus norvegicus (Rat)	actin cytoskeleton organization [GO:0030036]; activation of GTPase activity [GO:0090630]; angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; ephrin receptor signaling pathway [GO:0048013]; male genitalia development [GO:0030539]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of D-glucose import across plasma membrane [GO:0046326]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of GTPase activity [GO:0043547]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; regulation of actin filament polymerization [GO:0030833]; regulation of intracellular signal transduction [GO:1902531]; response to insulin [GO:0032868]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570]	GTPase activator activity [GO:0005096]; GTPase binding [GO:0051020]; phosphotyrosine residue binding [GO:0001784]; platelet-derived growth factor receptor binding [GO:0005161]; protein kinase B binding [GO:0043422]; protein tyrosine kinase binding [GO:1990782]; protein-containing complex binding [GO:0044877]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GO:0000281; GO:0001525; GO:0001570; GO:0001726; GO:0001784; GO:0001934; GO:0001953; GO:0005096; GO:0005102; GO:0005161; GO:0005737; GO:0005829; GO:0005886; GO:0007155; GO:0007162; GO:0007165; GO:0009410; GO:0030036; GO:0030539; GO:0030833; GO:0030971; GO:0031965; GO:0032868; GO:0036120; GO:0043066; GO:0043422; GO:0043524; GO:0043547; GO:0044325; GO:0044344; GO:0044877; GO:0046326; GO:0048013; GO:0048146; GO:0048514; GO:0050731; GO:0051020; GO:0071364; GO:0090630; GO:1902531; GO:1990782
GN017017	GN017017.1	Q17QS1	39.6	91	114	169	1.63e-10	58.2	SNX24_BOVIN	Sorting nexin-24	Bos taurus (Bovine)		phosphatidylinositol binding [GO:0035091]; phosphatidylinositol phosphate binding [GO:1901981]	cytoplasmic vesicle membrane [GO:0030659]	GO:0030659; GO:0035091; GO:1901981
GN017018	GN017018.1	Q1LWH4	42.2	649	888	988	4.16e-166	512	FAN1_DANRE	Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (Myotubularin-related protein 15)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; nucleotide-excision repair [GO:0006289]	5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; flap-structured DNA binding [GO:0070336]; phosphodiesterase I activity [GO:0004528]; ubiquitin-modified protein reader activity [GO:0140036]	nucleus [GO:0005634]	GO:0000724; GO:0004528; GO:0005634; GO:0006281; GO:0006289; GO:0008409; GO:0017108; GO:0036297; GO:0070336; GO:0140036
GN017019	GN017019.1	Q6JAN0	35.8	1652	1819	6199	8.77e-278	899	AGRV1_DANRE	Adhesion G protein-coupled receptor V1 (EC 3.4.-.-) (G protein-coupled receptor 98) (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G protein-coupled receptor 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	cell surface receptor signaling pathway [GO:0007166]; cellular response to calcium ion [GO:0071277]; eye photoreceptor cell development [GO:0042462]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of protein stability [GO:0031647]; self proteolysis [GO:0097264]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]	adenylate cyclase inhibitor activity [GO:0010855]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]	cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]	GO:0001917; GO:0001965; GO:0004930; GO:0005737; GO:0005886; GO:0007166; GO:0007186; GO:0007601; GO:0007605; GO:0010855; GO:0031647; GO:0032420; GO:0042462; GO:0060171; GO:0071277; GO:0097264
GN017020	GN017020.1	B0BML1	43.7	151	169	190	2.04e-37	130	GNTK_XENTR	Gluconokinase (EC 2.7.1.12) (Gluconate kinase)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	carbohydrate metabolic process [GO:0005975]	gluconokinase activity [GO:0046316]		GO:0005975; GO:0046316
GN017022	GN017022.1	Q6P5H6	48.4	347	633	517	1.02e-104	330	FRMD5_MOUSE	FERM domain-containing protein 5	Mus musculus (Mouse)	actomyosin structure organization [GO:0031032]; negative regulation of cell motility [GO:2000146]; positive regulation of cell adhesion [GO:0045785]; regulation of cell migration [GO:0030334]	cytoskeletal protein binding [GO:0008092]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]	adherens junction [GO:0005912]; cytoskeleton [GO:0005856]	GO:0005178; GO:0005856; GO:0005912; GO:0008092; GO:0019901; GO:0030334; GO:0031032; GO:0045785; GO:2000146
GN017023	GN017023.1	P05099	29.0	417	599	493	3.17e-45	170	MATN1_CHICK	Matrilin-1 (Cartilage matrix protein)	Gallus gallus (Chicken)		calcium ion binding [GO:0005509]	extracellular matrix [GO:0031012]	GO:0005509; GO:0031012
GN017031	GN017031.1	Q8NFW1	40.7	162	162	1626	2.72e-25	104	COMA1_HUMAN	Collagen alpha-1(XXII) chain	Homo sapiens (Human)	extracellular matrix organization [GO:0030198]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	basement membrane [GO:0005604]; collagen type XXII trimer [GO:1990321]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]	GO:0005576; GO:0005604; GO:0005788; GO:0030020; GO:0030198; GO:1990321
GN017034	GN017034.1	P05099	27.3	450	668	493	2.44e-40	157	MATN1_CHICK	Matrilin-1 (Cartilage matrix protein)	Gallus gallus (Chicken)		calcium ion binding [GO:0005509]	extracellular matrix [GO:0031012]	GO:0005509; GO:0031012
GN017035	GN017035.1	A6NMZ7	30.3	409	609	2263	8.11e-49	187	CO6A6_HUMAN	Collagen alpha-6(VI) chain	Homo sapiens (Human)	extracellular matrix organization [GO:0030198]		collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005589; GO:0030198; GO:0031012
GN017036	GN017036.1	Q8L4N1	32.9	167	153	260	1.63e-15	74.3	PHO34_ARATH	Universal stress protein PHOS34 (Phosphorylated protein of 34 kDa) (AtPHOS34)	Arabidopsis thaliana (Mouse-ear cress)	response to molecule of fungal origin [GO:0002238]		chloroplast [GO:0009507]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0002238; GO:0005634; GO:0005829; GO:0009507
GN017039	GN017039.1	Q5REQ8	54.6	163	357	385	1.67e-57	194	DCP2_PONAB	m7GpppN-mRNA hydrolase (EC 3.6.1.62) (mRNA-decapping enzyme 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; histone mRNA catabolic process [GO:0071044]; mRNA catabolic process [GO:0006402]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of mRNA stability [GO:0043488]	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity [GO:0140933]; manganese ion binding [GO:0030145]; RNA binding [GO:0003723]	nucleus [GO:0005634]; P-body [GO:0000932]	GO:0000184; GO:0000290; GO:0000932; GO:0003723; GO:0005634; GO:0006402; GO:0030145; GO:0043488; GO:0071044; GO:0140933
GN017041	GN017041.1	Q17QW3	42.6	94	129	336	1.14e-15	74.7	RDH14_BOVIN	Retinol dehydrogenase 14 (EC 1.1.1.300)	Bos taurus (Bovine)	retinol metabolic process [GO:0042572]	11-cis-retinol dehydrogenase (NADP+) activity [GO:0102354]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; photoreceptor outer segment [GO:0001750]	GO:0001750; GO:0005654; GO:0005783; GO:0005829; GO:0042572; GO:0052650; GO:0102354
GN017042	GN017042.1	Q17QW3	44.9	294	283	336	5.73e-75	235	RDH14_BOVIN	Retinol dehydrogenase 14 (EC 1.1.1.300)	Bos taurus (Bovine)	retinol metabolic process [GO:0042572]	11-cis-retinol dehydrogenase (NADP+) activity [GO:0102354]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; photoreceptor outer segment [GO:0001750]	GO:0001750; GO:0005654; GO:0005783; GO:0005829; GO:0042572; GO:0052650; GO:0102354
GN017043	GN017043.1	Q62651	55.4	278	279	327	6.20e-110	323	ECH1_RAT	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.21)	Rattus norvegicus (Rat)	fatty acid beta-oxidation [GO:0006635]	delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity [GO:0051750]	mitochondrion [GO:0005739]; peroxisome [GO:0005777]	GO:0005739; GO:0005777; GO:0006635; GO:0051750
GN017045	GN017045.1	Q17QW3	44.9	294	283	336	5.73e-75	235	RDH14_BOVIN	Retinol dehydrogenase 14 (EC 1.1.1.300)	Bos taurus (Bovine)	retinol metabolic process [GO:0042572]	11-cis-retinol dehydrogenase (NADP+) activity [GO:0102354]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; photoreceptor outer segment [GO:0001750]	GO:0001750; GO:0005654; GO:0005783; GO:0005829; GO:0042572; GO:0052650; GO:0102354
GN017048	GN017048.1	Q8N2M8	61.1	337	679	674	3.00e-105	337	CLASR_HUMAN	CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2)	Homo sapiens (Human)			nucleoplasm [GO:0005654]	GO:0005654
GN017051	GN017051.1	Q17QW3	45.4	295	317	336	2.59e-74	234	RDH14_BOVIN	Retinol dehydrogenase 14 (EC 1.1.1.300)	Bos taurus (Bovine)	retinol metabolic process [GO:0042572]	11-cis-retinol dehydrogenase (NADP+) activity [GO:0102354]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; photoreceptor outer segment [GO:0001750]	GO:0001750; GO:0005654; GO:0005783; GO:0005829; GO:0042572; GO:0052650; GO:0102354
GN017055	GN017055.1	P86982	53.2	141	280	148	6.09e-41	141	IMSP1_RUDPH	Insoluble matrix shell protein 1 (IMSP1)	Ruditapes philippinarum (Japanese carpet shell) (Venerupis philippinarum)			extracellular region [GO:0005576]	GO:0005576
GN017057	GN017057.1	Q99N01	36.5	480	518	723	1.70e-98	316	SO4A1_RAT	Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12)	Rattus norvegicus (Rat)	sodium-independent organic anion transport [GO:0043252]; thyroid hormone metabolic process [GO:0042403]	prostaglandin transmembrane transporter activity [GO:0015132]; thyroid hormone transmembrane transporter activity [GO:0015349]; transmembrane transporter activity [GO:0022857]	basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; plasma membrane [GO:0005886]	GO:0005886; GO:0015132; GO:0015349; GO:0016323; GO:0022857; GO:0030054; GO:0042403; GO:0043252
GN017066	GN017066.1	Q91684	45.3	1220	1123	1200	0.0	1013	DPOG1_XENLA	DNA polymerase subunit gamma-1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit)	Xenopus laevis (African clawed frog)	mitochondrial DNA replication [GO:0006264]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; single-stranded DNA 3'-5' DNA exonuclease activity [GO:0008310]	gamma DNA polymerase complex [GO:0005760]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]	GO:0003677; GO:0003682; GO:0003887; GO:0005759; GO:0005760; GO:0006264; GO:0008310; GO:0042645
GN017071	GN017071.1	Q9FT69	32.1	140	149	858	2.07e-11	63.9	RQSIM_ARATH	ATP-dependent DNA helicase Q-like SIM (EC 5.6.2.4) (DNA 3'-5' helicase RecQSIM) (RecQ-like protein SIM) (AtRecQsim) (Similar to RecQ protein)	Arabidopsis thaliana (Mouse-ear cress)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003676; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0016887; GO:0043138
GN017075	GN017075.1	Q32LB5	39.5	157	189	241	1.33e-31	117	GPRL1_BOVIN	GLIPR1-like protein 1	Bos taurus (Bovine)	fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]		acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; protein complex involved in cell-cell adhesion [GO:0098635]	GO:0001669; GO:0005576; GO:0005886; GO:0007342; GO:0045121; GO:0098635
GN017078	GN017078.1	E9PV86	25.8	302	1110	951	5.20e-15	84.0	MCTP1_MOUSE	Multiple C2 and transmembrane domain-containing protein 1	Mus musculus (Mouse)	negative regulation of cell migration [GO:0030336]; negative regulation of endocytosis [GO:0045806]; negative regulation of response to oxidative stress [GO:1902883]; regulation of neurotransmitter secretion [GO:0046928]	calcium ion binding [GO:0005509]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; recycling endosome [GO:0055037]; synaptic vesicle membrane [GO:0030672]	GO:0005509; GO:0005789; GO:0016020; GO:0030336; GO:0030672; GO:0045806; GO:0046928; GO:0055037; GO:1902883
GN017079	GN017079.1	Q9P203	46.9	683	804	1132	5.57e-206	617	BTBD7_HUMAN	BTB/POZ domain-containing protein 7	Homo sapiens (Human)	morphogenesis of a branching epithelium [GO:0061138]; regulation of branching involved in salivary gland morphogenesis [GO:0060693]		nucleus [GO:0005634]	GO:0005634; GO:0060693; GO:0061138
GN017081	GN017081.1	Q8N6Q8	29.2	685	684	603	3.60e-71	245	MET25_HUMAN	Probable methyltransferase-like protein 25 (EC 2.1.1.-)	Homo sapiens (Human)				
GN017082	GN017082.1	Q9BYB4	38.8	317	305	327	1.08e-64	209	GNB1L_HUMAN	Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (DGCRK3) (WD repeat-containing protein 14) (WD40 repeat-containing protein deleted in VCFS) (WDVCF)	Homo sapiens (Human)	DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000077; GO:0005634; GO:0005737; GO:0006974
GN017083	GN017083.1	Q00IB7	38.6	1494	1494	1433	1.52e-273	825	PKHH1_DANRE	Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) (Protein max-1 homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	blood vessel morphogenesis [GO:0048514]; branching involved in blood vessel morphogenesis [GO:0001569]		cytoskeleton [GO:0005856]	GO:0001569; GO:0005856; GO:0048514
GN017084	GN017084.1	A4IIN5	42.6	176	397	362	1.96e-20	95.1	TISD_XENTR	mRNA decay activator protein ZFP36L2 (Zinc finger protein 36, C3H1 type-like 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; definitive hemopoiesis [GO:0060216]; ERK1 and ERK2 cascade [GO:0070371]; hemopoiesis [GO:0030097]; MAPK cascade [GO:0000165]; mRNA catabolic process [GO:0006402]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; negative regulation of stem cell differentiation [GO:2000737]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; pronephros development [GO:0048793]; regulation of B cell differentiation [GO:0045577]; regulation of mRNA stability [GO:0043488]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]	metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA regulatory element binding translation repressor activity [GO:0000900]; protein-RNA sequence-specific adaptor activity [GO:0160134]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000165; GO:0000288; GO:0000289; GO:0000900; GO:0005634; GO:0005737; GO:0005829; GO:0006402; GO:0030097; GO:0031086; GO:0035019; GO:0035925; GO:0043488; GO:0044344; GO:0045577; GO:0045599; GO:0046872; GO:0048103; GO:0048793; GO:0060216; GO:0061158; GO:0070371; GO:0071356; GO:0071364; GO:0071385; GO:0071560; GO:0097011; GO:0160134; GO:1900153; GO:1901991; GO:2000737
GN017094	GN017094.1	Q9VZW5	30.2	315	333	549	9.95e-21	96.3	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN017095	GN017095.1	Q9VZW5	30.3	310	327	549	2.38e-22	100	FMAR_DROME	FMRFamide receptor (DFR) (DrmFMRFa-R)	Drosophila melanogaster (Fruit fly)	adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; flight behavior [GO:0007629]; G protein-coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]	neuropeptide receptor activity [GO:0008188]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0002209; GO:0005886; GO:0007186; GO:0007204; GO:0007218; GO:0007629; GO:0008188; GO:0008344; GO:0008345; GO:0016020; GO:0032226
GN017099	GN017099.1	P34140	32.7	150	255	206	1.44e-19	87.0	RAB1B_DICDI	Ras-related protein Rab-1B	Dictyostelium discoideum (Social amoeba)	hypotonic response [GO:0006971]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]; pathogen-containing vacuole [GO:0140220]; phagophore assembly site membrane [GO:0034045]	GO:0003924; GO:0005525; GO:0005737; GO:0005811; GO:0006971; GO:0016020; GO:0034045; GO:0140220
GN017106	GN017106.1	Q8CE96	37.9	103	124	497	3.75e-15	73.6	TRM6_MOUSE	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6)	Mus musculus (Mouse)	mRNA processing [GO:0006397]; tRNA methylation [GO:0030488]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515]	GO:0005634; GO:0005654; GO:0006397; GO:0030488; GO:0031515
GN017108	GN017108.1	Q8CE96	40.3	278	279	497	4.36e-60	201	TRM6_MOUSE	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6)	Mus musculus (Mouse)	mRNA processing [GO:0006397]; tRNA methylation [GO:0030488]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515]	GO:0005634; GO:0005654; GO:0006397; GO:0030488; GO:0031515
GN017110	GN017110.1	P20585	48.9	929	1128	1137	1.14e-293	855	MSH3_HUMAN	DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1)	Homo sapiens (Human)	DNA repair [GO:0006281]; maintenance of DNA repeat elements [GO:0043570]; mismatch repair [GO:0006298]; mitotic recombination [GO:0006312]; negative regulation of DNA recombination [GO:0045910]; somatic recombination of immunoglobulin gene segments [GO:0016447]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; enzyme binding [GO:0019899]; mismatched DNA binding [GO:0030983]	membrane [GO:0016020]; MutSbeta complex [GO:0032302]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005524; GO:0005634; GO:0005654; GO:0006281; GO:0006298; GO:0006312; GO:0016020; GO:0016447; GO:0019899; GO:0030983; GO:0032302; GO:0043570; GO:0045910; GO:0140664
GN017111	GN017111.1	Q9P2P6	28.0	189	660	4700	8.42e-12	72.8	STAR9_HUMAN	StAR-related lipid transfer protein 9 (START domain-containing protein 9) (StARD9)	Homo sapiens (Human)	microtubule-based movement [GO:0007018]; spindle assembly [GO:0051225]	ATP binding [GO:0005524]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003777; GO:0005524; GO:0005634; GO:0005737; GO:0005814; GO:0007018; GO:0008017; GO:0008289; GO:0051225
GN017112	GN017112.1	Q9CW42	40.4	297	323	340	1.59e-66	215	MARC1_MOUSE	Mitochondrial amidoxime-reducing component 1 (mARC1) (EC 1.7.-.-) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 1) (MOSC domain-containing protein 1) (Moco sulfurase C-terminal domain-containing protein 1)	Mus musculus (Mouse)	cellular detoxification of nitrogen compound [GO:0070458]; nitrate metabolic process [GO:0042126]; nitric oxide biosynthetic process [GO:0006809]	molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940]; nitrite reductase (NO-forming) activity [GO:0050421]; nitrite reductase activity [GO:0098809]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; pyridoxal phosphate binding [GO:0030170]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nitric-oxide synthase complex [GO:1903958]	GO:0005739; GO:0005741; GO:0005743; GO:0006809; GO:0008940; GO:0016020; GO:0016661; GO:0030151; GO:0030170; GO:0042126; GO:0043546; GO:0050421; GO:0070458; GO:0098809; GO:1903958
GN017113	GN017113.1	Q01314	63.4	484	488	480	1.03e-221	622	AKT1_BOVIN	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (RAC-PK-alpha)	Bos taurus (Bovine)	cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; negative regulation of cilium assembly [GO:1902018]; negative regulation of protein localization to lysosome [GO:0150033]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of TORC1 signaling [GO:1904263]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of neuron projection development [GO:0010975]; response to growth factor [GO:0070848]; response to growth hormone [GO:0060416]; response to insulin-like growth factor stimulus [GO:1990418]; response to peptide hormone [GO:0043434]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; potassium channel activator activity [GO:0099104]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; mitochondrial intermembrane space [GO:0005758]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0001938; GO:0004672; GO:0004674; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0005758; GO:0005886; GO:0010975; GO:0030334; GO:0032869; GO:0042981; GO:0043434; GO:0046889; GO:0060416; GO:0070848; GO:0071363; GO:0071364; GO:0090201; GO:0099104; GO:0106310; GO:0150033; GO:1902018; GO:1904263; GO:1990418
GN017114	GN017114.1	Q99NE9	28.2	156	396	378	4.76e-10	64.3	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017115	GN017115.1	Q99NE9	28.2	156	396	378	3.57e-10	64.7	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017116	GN017116.1	Q99NE9	28.8	170	407	378	2.84e-10	65.1	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017117	GN017117.1	Q99NE9	28.2	170	407	378	2.84e-09	62.0	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017120	GN017120.1	Q99NE9	42.5	73	147	378	3.61e-10	60.1	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017121	GN017121.1	Q99NE9	28.8	170	407	378	2.84e-10	65.1	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017122	GN017122.1	Q99NE9	29.4	170	407	378	5.03e-11	67.4	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017123	GN017123.1	Q99NE9	28.2	156	407	378	3.80e-10	64.7	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017124	GN017124.1	Q99NE9	28.2	170	407	378	2.84e-09	62.0	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017125	GN017125.1	Q99NE9	28.2	156	407	378	1.20e-09	63.2	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017126	GN017126.1	Q99NE9	28.8	170	407	378	2.84e-10	65.1	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017127	GN017127.1	Q99NE9	28.8	170	407	378	1.60e-10	65.9	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017128	GN017128.1	Q99NE9	27.6	156	396	378	1.51e-09	62.8	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017129	GN017129.1	Q99NE9	28.8	156	407	378	2.84e-10	65.1	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN017130	GN017130.1	P27987	55.1	383	724	946	2.08e-122	391	IP3KB_HUMAN	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B)	Homo sapiens (Human)	cellular response to calcium ion [GO:0071277]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; inositol trisphosphate metabolic process [GO:0032957]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]; signal transduction [GO:0007165]	inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,4,5-trisphosphate 3-kinase activity [GO:0008440]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0000828; GO:0005634; GO:0005737; GO:0005783; GO:0005829; GO:0005856; GO:0007165; GO:0008440; GO:0016020; GO:0032957; GO:0032958; GO:0043647; GO:0046854; GO:0071277
GN017132	GN017132.1	Q0VAA2	36.6	93	640	488	2.61e-12	73.2	LR74A_HUMAN	Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74)	Homo sapiens (Human)				
GN017134	GN017134.1	P26221	42.5	447	665	880	2.27e-94	313	GUN4_THEFU	Endoglucanase E-4 (EC 3.2.1.4) (Cellulase E-4) (Cellulase E4) (Endo-1,4-beta-glucanase E-4)	Thermobifida fusca (Thermomonospora fusca)	cellulose catabolic process [GO:0030245]	cellulase activity [GO:0008810]; cellulose binding [GO:0030248]		GO:0008810; GO:0030245; GO:0030248
GN017135	GN017135.1	Q99PJ0	31.3	288	438	344	1.06e-32	129	NTRI_MOUSE	Neurotrimin	Mus musculus (Mouse)	heterophilic cell-cell adhesion [GO:0007157]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of neuron projection development [GO:0010977]; positive regulation of neuron projection development [GO:0010976]; positive regulation of Schwann cell migration [GO:1900149]; regulation of synapse assembly [GO:0051963]	identical protein binding [GO:0042802]	axon [GO:0030424]; cell surface [GO:0009986]; excitatory synapse [GO:0060076]; extracellular region [GO:0005576]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]	GO:0005576; GO:0005886; GO:0007157; GO:0009986; GO:0010976; GO:0010977; GO:0030424; GO:0042802; GO:0048471; GO:0048787; GO:0051963; GO:0060076; GO:0060253; GO:0098686; GO:0098839; GO:1900149
GN017136	GN017136.1	A0A3Q2HW92	33.6	584	579	478	4.68e-92	294	MFS12_HORSE	Major facilitator superfamily domain-containing protein 12	Equus caballus (Horse)	alternative mRNA splicing, via spliceosome [GO:0000380]; carbohydrate transport [GO:0008643]; L-cysteine transmembrane transport [GO:1903712]; negative regulation of melanin biosynthetic process [GO:0048022]; pigment metabolic process involved in pigmentation [GO:0043474]	L-cysteine transmembrane transporter activity [GO:0033229]; ribonucleoprotein complex binding [GO:0043021]; symporter activity [GO:0015293]	cytoplasm [GO:0005737]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; nuclear body [GO:0016604]	GO:0000380; GO:0005737; GO:0005764; GO:0005765; GO:0005770; GO:0008643; GO:0015293; GO:0016604; GO:0033162; GO:0033229; GO:0043021; GO:0043474; GO:0048022; GO:1903712
GN017137	GN017137.1	P31795	36.9	111	163	581	1.33e-14	73.6	POL_MLVRK	Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]	Radiation murine leukemia virus (strain Kaplan)	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; symbiont entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826]	nucleic acid binding [GO:0003676]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]		GO:0003676; GO:0003964; GO:0004523; GO:0006310; GO:0015074; GO:0044826; GO:0046718; GO:0075713
GN017138	GN017138.1	Q8K0U4	32.0	632	580	675	2.11e-83	277	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN017139	GN017139.1	F1NZI4	36.8	647	768	702	5.39e-134	416	PGGHG_CHICK	Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107) (Acid trehalase-like protein 1)	Gallus gallus (Chicken)	carbohydrate metabolic process [GO:0005975]	protein-glucosylgalactosylhydroxylysine glucosidase activity [GO:0047402]	cytosol [GO:0005829]	GO:0005829; GO:0005975; GO:0047402
GN017141	GN017141.1	Q7T3S3	31.8	195	350	352	1.38e-18	89.0	CHSTB_DANRE	Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4ST-1) (C4ST1) (zC4ST-1)	Danio rerio (Zebrafish) (Brachydanio rerio)	carbohydrate biosynthetic process [GO:0016051]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; motor neuron axon guidance [GO:0008045]; muscle organ development [GO:0007517]; proteoglycan biosynthetic process [GO:0030166]	chondroitin 4-sulfotransferase activity [GO:0047756]; sulfotransferase activity [GO:0008146]	Golgi membrane [GO:0000139]	GO:0000139; GO:0007517; GO:0008045; GO:0008146; GO:0016051; GO:0030166; GO:0047756; GO:0050650
GN017144	GN017144.1	P81178	71.0	500	519	519	1.33e-270	748	ALDH2_MESAU	Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.19) (EC 1.2.1.24) (EC 1.2.1.3) (EC 1.2.1.36) (EC 1.2.1.46) (ALDH class 2) (ALDH-2) (ALDH-E2) (ALDH1) (Nitroglycerin reductase ALDH2) (EC 1.7.1.-)	Mesocricetus auratus (Golden hamster)	aldehyde catabolic process [GO:0046185]; ethanol catabolic process [GO:0006068]	acetaldehyde dehydrogenase (NAD+) activity [GO:0140087]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; carboxylesterase activity [GO:0106435]; NAD binding [GO:0051287]; phenylacetaldehyde dehydrogenase (NAD+) activity [GO:0008957]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004029; GO:0005739; GO:0005759; GO:0006068; GO:0008957; GO:0046185; GO:0051287; GO:0106435; GO:0140087
GN017147	GN017147.1	Q9TU53	31.0	232	395	3620	4.06e-15	81.3	CUBN_CANLF	Cubilin	Canis lupus familiaris (Dog) (Canis familiaris)		calcium ion binding [GO:0005509]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; endosome [GO:0005768]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0005509; GO:0005765; GO:0005768; GO:0005886; GO:0016324; GO:0031526; GO:0043235
GN017148	GN017148.1	Q6PGP7	46.8	79	91	1564	6.53e-16	74.3	SKI3_HUMAN	Superkiller complex protein 3 (Ski3) (Tetratricopeptide repeat protein 37) (TPR repeat protein 37) (Tricho-hepatic-enteric syndrome protein) (Thespin)	Homo sapiens (Human)	nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled cytosolic ribosome [GO:0072344]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; euchromatin [GO:0000791]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Ski complex [GO:0055087]	GO:0000791; GO:0000956; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0055087; GO:0070478; GO:0072344
GN017149	GN017149.1	Q6DFB8	33.5	1258	1362	1564	2.89e-188	601	TTC37_XENLA	Tetratricopeptide repeat protein 37 (TPR repeat protein 37) (Thespin homolog)	Xenopus laevis (African clawed frog)	RNA catabolic process [GO:0006401]		cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nucleus [GO:0005634]; Ski complex [GO:0055087]	GO:0000791; GO:0005634; GO:0005737; GO:0006401; GO:0055087
GN017150	GN017150.1	Q9WU06	29.9	837	884	819	6.30e-84	290	AVIL_RAT	Advillin (Peripheral nervous system villin-like protein) (Pervin)	Rattus norvegicus (Rat)	actin filament organization [GO:0007015]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cilium assembly [GO:0060271]; nervous system development [GO:0007399]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of diacylglycerol biosynthetic process [GO:1900480]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	actin filament [GO:0005884]; axon [GO:0030424]; cell projection [GO:0042995]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]	GO:0003779; GO:0005546; GO:0005884; GO:0005925; GO:0007015; GO:0007399; GO:0008154; GO:0010592; GO:0010976; GO:0030027; GO:0030424; GO:0042995; GO:0043005; GO:0051014; GO:0051015; GO:0051016; GO:0060271; GO:0071933; GO:1900480
GN017152	GN017152.1	Q8IMC6	74.4	309	1160	1262	1.69e-149	484	ASATR_DROME	Tau-tubulin kinase homolog Asator (EC 2.7.11.1)	Drosophila melanogaster (Fruit fly)		ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; spindle [GO:0005819]	GO:0004674; GO:0005524; GO:0005737; GO:0005819; GO:0106310
GN017153	GN017153.1	A0A0G2L7I0	65.2	247	256	636	4.59e-116	348	SPRTN_DANRE	DNA-dependent metalloprotease SPRTN (EC 3.4.24.-) (Protein with SprT-like domain at the N terminus) (Spartan)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA damage response [GO:0006974]; protein autoprocessing [GO:0016540]; protein-DNA covalent cross-linking repair [GO:0106300]; proteolysis [GO:0006508]	double-stranded DNA binding [GO:0003690]; metalloendopeptidase activity [GO:0004222]; polyubiquitin modification-dependent protein binding [GO:0031593]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleus [GO:0005634]	GO:0000785; GO:0003690; GO:0003697; GO:0004222; GO:0005634; GO:0005694; GO:0006508; GO:0006974; GO:0016540; GO:0031593; GO:0106300
GN017154	GN017154.1	O77237	60.4	336	363	424	9.25e-145	419	PELI_DROME	Protein pellino	Drosophila melanogaster (Fruit fly)	innate immune response [GO:0045087]; negative regulation of antifungal innate immune response [GO:1905035]; negative regulation of defense response to bacterium [GO:1900425]; negative regulation of Toll signaling pathway [GO:0045751]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of Toll signaling pathway [GO:0045752]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]	kinase regulator activity [GO:0019207]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]	GO:0000209; GO:0002225; GO:0004842; GO:0005829; GO:0009898; GO:0019207; GO:0045087; GO:0045751; GO:0045752; GO:0061630; GO:0070936; GO:1900425; GO:1905035
GN017157	GN017157.1	Q6DI51	50.6	168	211	175	3.87e-53	171	NDK6_DANRE	Nucleoside diphosphate kinase 6, mitochondrial (NDK6) (NDP kinase 6) (EC 2.7.4.6)	Danio rerio (Zebrafish) (Brachydanio rerio)	CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; negative regulation of cell growth [GO:0030308]; negative regulation of mitotic nuclear division [GO:0045839]; nucleotide metabolic process [GO:0009117]; pyrimidine ribonucleotide salvage [GO:0010138]; UTP biosynthetic process [GO:0006228]	nucleoside diphosphate kinase activity [GO:0004550]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004550; GO:0005739; GO:0005743; GO:0005759; GO:0006183; GO:0006228; GO:0006241; GO:0009117; GO:0010138; GO:0030308; GO:0045839
GN017159	GN017159.1	A8TX70	21.3	352	1275	2615	8.26e-09	64.3	CO6A5_HUMAN	Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4)	Homo sapiens (Human)	extracellular matrix organization [GO:0030198]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005589; GO:0030020; GO:0030198; GO:0031012
GN017160	GN017160.1	Q641F3	27.3	183	188	957	1.00e-13	72.0	COLA1_XENLA	Collagen alpha-1(XXI) chain	Xenopus laevis (African clawed frog)			cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]	GO:0005737; GO:0031012
GN017161	GN017161.1	P12111	22.1	280	1396	3177	1.43e-09	67.0	CO6A3_HUMAN	Collagen alpha-3(VI) chain	Homo sapiens (Human)	muscle organ development [GO:0007517]; response to glucose [GO:0009749]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]; serine-type endopeptidase inhibitor activity [GO:0004867]	collagen type VI trimer [GO:0005589]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; microfibril [GO:0001527]	GO:0001527; GO:0004867; GO:0005576; GO:0005589; GO:0005788; GO:0007517; GO:0009749; GO:0030020; GO:0031012; GO:0070062; GO:1903561
GN017162	GN017162.1	P58304	67.6	170	356	361	2.11e-69	224	VSX2_HUMAN	Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000977; GO:0000981; GO:0001227; GO:0005634; GO:0005737; GO:0006357; GO:1990837
GN017164	GN017164.1	Q9IAL1	60.8	194	227	377	6.58e-70	221	VSX2_CHICK	Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10)	Gallus gallus (Chicken)	regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000976; GO:0000977; GO:0001227; GO:0005634; GO:0005737; GO:0006355
GN017165	GN017165.1	Q3LXA3	47.1	586	589	575	1.69e-167	491	TKFC_HUMAN	Triokinase/FMN cyclase (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)]	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; carbohydrate phosphorylation [GO:0046835]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; glycerol catabolic process [GO:0019563]; negative regulation of MDA-5 signaling pathway [GO:0039534]; regulation of innate immune response [GO:0045088]	ATP binding [GO:0005524]; FAD-AMP lyase (cyclizing) activity [GO:0034012]; glycerone kinase activity [GO:0004371]; triokinase activity [GO:0050354]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0004371; GO:0005524; GO:0005634; GO:0005829; GO:0005975; GO:0019563; GO:0034012; GO:0039534; GO:0045088; GO:0046835; GO:0050354; GO:0061624; GO:0070062
GN017166	GN017166.1	Q3LXA3	50.9	587	587	575	2.33e-180	524	TKFC_HUMAN	Triokinase/FMN cyclase (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)]	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; carbohydrate phosphorylation [GO:0046835]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; glycerol catabolic process [GO:0019563]; negative regulation of MDA-5 signaling pathway [GO:0039534]; regulation of innate immune response [GO:0045088]	ATP binding [GO:0005524]; FAD-AMP lyase (cyclizing) activity [GO:0034012]; glycerone kinase activity [GO:0004371]; triokinase activity [GO:0050354]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0004371; GO:0005524; GO:0005634; GO:0005829; GO:0005975; GO:0019563; GO:0034012; GO:0039534; GO:0045088; GO:0046835; GO:0050354; GO:0061624; GO:0070062
GN017167	GN017167.1	Q7RYW6	59.2	346	379	376	8.18e-141	408	CYSK_NEUCR	Cysteine synthase 1 (CS 1) (EC 2.5.1.-) (EC 2.5.1.47) (O-acetylserine (thiol)-lyase 1) (OAS-TL 1) (O-acetylserine sulfhydrylase 1) (O-succinylserine sulfhydrylase)	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)		cysteine synthase activity [GO:0004124]; cysteine synthase activity, acting on O-succinyl-L-serine [GO:0141223]	mitochondrion [GO:0005739]	GO:0004124; GO:0005739; GO:0141223
GN017168	GN017168.1	G5EFL9	37.9	354	825	676	2.18e-61	223	NPASH_CAEEL	PAS domain-containing protein cky-1 (CKY homolog) (bHLH-PAS transcription factor cky-1)	Caenorhabditis elegans	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]; transcription regulator complex [GO:0005667]	GO:0000977; GO:0000981; GO:0005634; GO:0005667; GO:0006357; GO:0045944; GO:0046983; GO:0090575
GN017169	GN017169.1	Q58CV6	60.7	244	824	382	5.19e-105	331	KLDC3_BOVIN	Kelch domain-containing protein 3	Bos taurus (Bovine)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	chromatin binding [GO:0003682]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	chromatin [GO:0000785]; Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]	GO:0000785; GO:0003682; GO:0005737; GO:0016567; GO:0031462; GO:0043161; GO:1990756
GN017170	GN017170.1	Q5XIW8	44.6	731	793	806	1.64e-150	463	SNUT1_RAT	U4/U6.U5 tri-snRNP-associated protein 1 (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (rSART-1)	Rattus norvegicus (Rat)	maturation of 5S rRNA [GO:0000481]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of cytotoxic T cell differentiation [GO:0045585]		Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type precatalytic spliceosome [GO:0071016]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	GO:0000398; GO:0000481; GO:0005634; GO:0005654; GO:0005794; GO:0015030; GO:0016607; GO:0045292; GO:0045585; GO:0046540; GO:0071005; GO:0071013; GO:0071016
GN017171	GN017171.1	Q9GZY0	57.7	52	124	626	1.93e-12	65.9	NXF2_HUMAN	Nuclear RNA export factor 2 (Cancer/testis antigen 39) (CT39) (TAP-like protein 2) (TAPL-2)	Homo sapiens (Human)	mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA transport [GO:0050658]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006406; GO:0016973; GO:0042272; GO:0050658
GN017173	GN017173.1	Q8BXJ9	37.5	523	528	643	5.51e-101	320	TMM62_MOUSE	Transmembrane protein 62	Mus musculus (Mouse)		hydrolase activity [GO:0016787]	membrane [GO:0016020]	GO:0016020; GO:0016787
GN017175	GN017175.1	Q86VZ4	44.6	83	1049	500	3.71e-10	67.4	LRP11_HUMAN	Low-density lipoprotein receptor-related protein 11 (LRP-11)	Homo sapiens (Human)	multicellular organismal response to stress [GO:0033555]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to immobilization stress [GO:0035902]; response to mechanical stimulus [GO:0009612]; response to starvation [GO:0042594]; response to water deprivation [GO:0009414]	phosphoprotein binding [GO:0051219]	plasma membrane [GO:0005886]	GO:0005886; GO:0009408; GO:0009409; GO:0009414; GO:0009612; GO:0033555; GO:0035902; GO:0042594; GO:0051219
GN017178	GN017178.1	Q6PWT7	46.4	263	254	274	7.62e-77	236	CCS_PIG	Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone)	Sus scrofa (Pig)	removal of superoxide radicals [GO:0019430]	copper ion binding [GO:0005507]	cytosol [GO:0005829]	GO:0005507; GO:0005829; GO:0019430
GN017180	GN017180.1	Q5E9X5	36.4	456	474	490	4.03e-97	304	AP5M1_BOVIN	AP-5 complex subunit mu-1 (Adaptor-related protein complex 5 subunit mu-1) (Mu5)	Bos taurus (Bovine)	endosomal transport [GO:0016197]		AP-type membrane coat adaptor complex [GO:0030119]; cytosol [GO:0005829]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]	GO:0005764; GO:0005765; GO:0005770; GO:0005829; GO:0016020; GO:0016197; GO:0030119; GO:0031902
GN017181	GN017181.1	Q3Y4E2	37.0	508	565	557	1.42e-91	295	SELN_DANRE	Selenoprotein N (SePN) (SelN)	Danio rerio (Zebrafish) (Brachydanio rerio)	calcium ion homeostasis [GO:0055074]; calcium-mediated signaling [GO:0019722]; muscle cell development [GO:0055001]; muscle tissue development [GO:0060537]; regulation of locomotion [GO:0040012]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; skeletal muscle fiber development [GO:0048741]; swimming behavior [GO:0036269]		endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0019722; GO:0036269; GO:0040012; GO:0048741; GO:0055001; GO:0055074; GO:0060314; GO:0060537
GN017182	GN017182.1	Q9BX10	63.1	529	918	602	9.01e-230	664	GTPB2_HUMAN	GTP-binding protein 2	Homo sapiens (Human)	translational elongation [GO:0006414]	alpha-aminoacyl-tRNA binding [GO:1904678]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]	extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093]	GO:0003924; GO:0005525; GO:0005576; GO:0006414; GO:0031093; GO:0042802; GO:1904678
GN017183	GN017183.1	Q9Y4D1	50.1	1062	1181	1078	1.49e-315	910	DAAM1_HUMAN	Disheveled-associated activator of morphogenesis 1	Homo sapiens (Human)	presynaptic actin cytoskeleton organization [GO:0099140]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	actin binding [GO:0003779]; identical protein binding [GO:0042802]; small GTPase binding [GO:0031267]	ciliary basal body [GO:0036064]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; motile cilium [GO:0031514]; perinuclear region of cytoplasm [GO:0048471]; presynapse [GO:0098793]; stress fiber [GO:0001725]	GO:0001725; GO:0003779; GO:0005829; GO:0016020; GO:0031267; GO:0031514; GO:0036064; GO:0042802; GO:0048471; GO:0060071; GO:0098793; GO:0098978; GO:0099140
GN017184	GN017184.1	Q9NZM5	32.6	439	410	478	1.47e-37	145	NOP53_HUMAN	Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60)	Homo sapiens (Human)	cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein-containing complex assembly [GO:0031333]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901837]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; protein localization to nucleolus [GO:1902570]; protein localization to nucleoplasm [GO:1990173]; protein stabilization [GO:0050821]; regulation of aerobic respiration [GO:1903715]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of protein phosphorylation [GO:0001932]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]	5S rRNA binding [GO:0008097]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; RNA binding [GO:0003723]	cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0000027; GO:0000122; GO:0001650; GO:0001932; GO:0002039; GO:0003723; GO:0005654; GO:0005730; GO:0005829; GO:0006281; GO:0006974; GO:0007095; GO:0008097; GO:0031333; GO:0032435; GO:0032436; GO:0039535; GO:0042802; GO:0042981; GO:0050821; GO:0051726; GO:0051898; GO:0071456; GO:1901796; GO:1901797; GO:1901837; GO:1902570; GO:1903006; GO:1903715; GO:1990173
GN017185	GN017185.1	Q32L99	57.4	296	298	351	3.43e-110	326	PTGR2_BOVIN	Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase)	Bos taurus (Bovine)	prostaglandin metabolic process [GO:0006693]	15-oxoprostaglandin 13-reductase [NAD(P)+] activity [GO:0047522]	cytoplasm [GO:0005737]	GO:0005737; GO:0006693; GO:0047522
GN017186	GN017186.1	Q40302	40.6	143	186	149	7.49e-33	117	CALM_MACPY	Calmodulin (CaM)	Macrocystis pyrifera (Giant kelp) (Fucus pyrifer)		calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; myosin II complex [GO:0016460]	GO:0005509; GO:0005737; GO:0016460
GN017187	GN017187.1	Q8R2Q4	46.2	730	780	779	4.01e-212	620	RRF2M_MOUSE	Ribosome-releasing factor 2, mitochondrial (RRF2mt) (EC 3.6.5.-) (Elongation factor G 2, mitochondrial) (EF-G2mt) (mEF-G 2)	Mus musculus (Mouse)	mitochondrial translation [GO:0032543]; ribosome disassembly [GO:0032790]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003924; GO:0005525; GO:0005739; GO:0005759; GO:0032543; GO:0032790
GN017189	GN017189.1	Q924S7	38.3	436	446	410	2.37e-88	278	SPRE2_MOUSE	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)	Mus musculus (Mouse)	negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of intracellular signal transduction [GO:1902532]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]	protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; stem cell factor receptor binding [GO:0005173]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]	GO:0005173; GO:0005737; GO:0005829; GO:0005886; GO:0010719; GO:0019901; GO:0030291; GO:0030512; GO:0030658; GO:0031410; GO:0043409; GO:0043517; GO:0070373; GO:1902532; GO:1902747
GN017190	GN017190.1	A6H7E2	37.4	195	215	212	1.86e-32	119	CINP_BOVIN	Cyclin-dependent kinase 2-interacting protein	Bos taurus (Bovine)	ribosomal large subunit biogenesis [GO:0042273]	preribosome binding [GO:1990275]	nucleus [GO:0005634]	GO:0005634; GO:0042273; GO:1990275
GN017200	GN017200.1	P05099	28.6	454	659	493	3.11e-52	191	MATN1_CHICK	Matrilin-1 (Cartilage matrix protein)	Gallus gallus (Chicken)		calcium ion binding [GO:0005509]	extracellular matrix [GO:0031012]	GO:0005509; GO:0031012
GN017202	GN017202.1	Q9CS00	58.0	654	750	772	2.50e-241	693	CATIN_MOUSE	Splicing factor Cactin	Mus musculus (Mouse)	cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]		catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000398; GO:0001933; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0005829; GO:0016607; GO:0031665; GO:0032688; GO:0032717; GO:0032720; GO:0034122; GO:0043124; GO:0045292; GO:0045824; GO:0060339; GO:0071006; GO:0071007; GO:0071013; GO:0071222; GO:0071347; GO:0071356
GN017204	GN017204.1	Q5REX3	49.6	1001	965	1074	1.53e-236	700	ZFR_PONAB	Zinc finger RNA-binding protein	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)		double-stranded RNA binding [GO:0003725]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; precatalytic spliceosome [GO:0071011]	GO:0003725; GO:0003727; GO:0005694; GO:0005737; GO:0008270; GO:0071011
GN017205	GN017205.1	Q00657	25.9	2198	2344	2326	4.78e-211	702	CSPG4_RAT	Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (HSN tumor-specific antigen)	Rattus norvegicus (Rat)	glial cell migration [GO:0008347]; intracellular signal transduction [GO:0035556]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; neuron remodeling [GO:0016322]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; ruffle assembly [GO:0097178]; signal transduction [GO:0007165]; substrate-dependent cell migration [GO:0006929]	collagen binding [GO:0005518]; coreceptor activity [GO:0015026]; protein kinase binding [GO:0019901]	apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GO:0001726; GO:0005518; GO:0005886; GO:0006929; GO:0007165; GO:0007399; GO:0008347; GO:0009986; GO:0010977; GO:0015026; GO:0016322; GO:0016324; GO:0019901; GO:0031258; GO:0035556; GO:0043410; GO:0048008; GO:0050731; GO:0097178
GN017206	GN017206.1	A7YSY2	41.2	769	748	767	1.36e-174	522	AFG2B_BOVIN	ATPase family gene 2 protein homolog B (EC 3.6.4.10) (AFG2 AAA ATPase homolog B) (Ribosome biogenesis protein SPATA5L1) (Spermatogenesis-associated protein 5-like protein 1)	Bos taurus (Bovine)	autophagosome maturation [GO:0097352]; DNA replication [GO:0006260]; mitotic spindle disassembly [GO:0051228]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of ribosome biogenesis [GO:0090069]; retrograde protein transport, ER to cytosol [GO:0030970]; ribosomal large subunit biogenesis [GO:0042273]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; identical protein binding [GO:0042802]; polyubiquitin modification-dependent protein binding [GO:0031593]; preribosome binding [GO:1990275]	ATPase complex [GO:1904949]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle [GO:0005819]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	GO:0005524; GO:0005634; GO:0005737; GO:0005819; GO:0006260; GO:0016887; GO:0030970; GO:0031593; GO:0034098; GO:0042273; GO:0042802; GO:0043161; GO:0051228; GO:0090069; GO:0097352; GO:1904949; GO:1990275
GN017207	GN017207.1	Q9JME5	59.7	1083	1072	1082	0.0	1004	AP3B2_MOUSE	AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain)	Mus musculus (Mouse)	adult locomotory behavior [GO:0008344]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; clathrin-coated vesicle cargo loading, AP-3-mediated [GO:0035654]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; intracellular zinc ion homeostasis [GO:0006882]; protein-containing complex assembly [GO:0065003]; synaptic vesicle coating [GO:0016183]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle membrane organization [GO:0048499]; synaptic vesicle recycling [GO:0036465]; vesicle-mediated transport [GO:0016192]; zinc ion import into synaptic vesicle [GO:0099180]	AP-3 adaptor complex binding [GO:0035651]	AP-3 adaptor complex [GO:0030123]; axon cytoplasm [GO:1904115]; clathrin-coated vesicle membrane [GO:0030665]; early endosome [GO:0005769]; neuron projection [GO:0043005]; presynapse [GO:0098793]; trans-Golgi network [GO:0005802]	GO:0005769; GO:0005802; GO:0006882; GO:0006886; GO:0006897; GO:0008089; GO:0008344; GO:0016183; GO:0016192; GO:0030123; GO:0030665; GO:0035651; GO:0035654; GO:0036465; GO:0043005; GO:0048488; GO:0048490; GO:0048499; GO:0065003; GO:0098793; GO:0099180; GO:1904115
GN017208	GN017208.1	Q8K021	48.0	352	368	338	1.36e-88	273	SCAM1_MOUSE	Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1)	Mus musculus (Mouse)	endocytosis [GO:0006897]; exocytosis [GO:0006887]; protein transport [GO:0015031]	protein domain specific binding [GO:0019904]	clathrin-coated vesicle [GO:0030136]; cytoplasmic vesicle membrane [GO:0030659]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; zymogen granule membrane [GO:0042589]	GO:0005802; GO:0006887; GO:0006897; GO:0008021; GO:0015031; GO:0016020; GO:0019904; GO:0030136; GO:0030659; GO:0030672; GO:0032588; GO:0042589; GO:0045202; GO:0055038
GN017209	GN017209.1	Q9VE46	46.2	507	555	614	1.02e-138	418	SC5A7_DROME	High-affinity choline transporter 1	Drosophila melanogaster (Fruit fly)	acetylcholine biosynthetic process [GO:0008292]; amino acid transmembrane transport [GO:0003333]; choline transport [GO:0015871]	amino acid transmembrane transporter activity [GO:0015171]; choline transmembrane transporter activity [GO:0015220]; choline:sodium symporter activity [GO:0005307]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0003333; GO:0005307; GO:0005886; GO:0008292; GO:0015171; GO:0015220; GO:0015871; GO:0016020
GN017210	GN017210.1	Q562D6	38.1	388	317	431	1.90e-73	235	TRMO_MOUSE	tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O)	Mus musculus (Mouse)	tRNA methylation [GO:0030488]	tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity [GO:0089715]		GO:0030488; GO:0089715
GN017212	GN017212.1	Q562D6	44.0	384	352	431	5.85e-89	276	TRMO_MOUSE	tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O)	Mus musculus (Mouse)	tRNA methylation [GO:0030488]	tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity [GO:0089715]		GO:0030488; GO:0089715
GN017213	GN017213.1	Q9NVE4	25.5	933	1106	849	8.23e-54	206	CCD87_HUMAN	Coiled-coil domain-containing protein 87	Homo sapiens (Human)	positive regulation of acrosome reaction [GO:2000344]; positive regulation of fertilization [GO:1905516]			GO:1905516; GO:2000344
GN017214	GN017214.1	G5CTG7	48.7	298	341	409	1.72e-99	302	AQP10_MILTA	Aquaporin-10 (AQP-10)	Milnesium tardigradum (Water bear) (Tardigrade)		glycerol channel activity [GO:0015254]; water channel activity [GO:0015250]	basolateral plasma membrane [GO:0016323]	GO:0015250; GO:0015254; GO:0016323
GN017215	GN017215.1	Q7Z3E1	41.5	205	275	657	3.13e-43	159	PARPT_HUMAN	Protein mono-ADP-ribosyltransferase TIPARP (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) (TCDD-inducible poly [ADP-ribose] polymerase)	Homo sapiens (Human)	negative regulation of gene expression [GO:0010629]; positive regulation of protein catabolic process [GO:0045732]; protein auto-ADP-ribosylation [GO:0070213]; response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904612]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; metal ion binding [GO:0046872]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]	nucleus [GO:0005634]	GO:0000987; GO:0003950; GO:0005634; GO:0010629; GO:0045732; GO:0046872; GO:0070213; GO:0140803; GO:0140806; GO:0140807; GO:1904612; GO:1990404
GN017217	GN017217.1	Q3SX11	83.5	194	194	260	1.36e-118	339	NSA2_BOVIN	Ribosome biogenesis protein NSA2 homolog (TGF-beta-inducible nuclear protein 1)	Bos taurus (Bovine)	maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]		nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]	GO:0000460; GO:0000470; GO:0005730; GO:0030687
GN017218	GN017218.1	Q8IV33	23.2	1308	1325	1275	2.18e-75	278	K0825_HUMAN	Uncharacterized protein KIAA0825	Homo sapiens (Human)				
GN017221	GN017221.1	Q804S5	25.8	209	813	1030	1.41e-10	68.9	MIB1_DANRE	E3 ubiquitin-protein ligase mib1 (EC 2.3.2.27) (Protein mind bomb) (RING-type E3 ubiquitin transferase mib1)	Danio rerio (Zebrafish) (Brachydanio rerio)	anterior lateral line development [GO:0048899]; blood vessel development [GO:0001568]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; central nervous system development [GO:0007417]; definitive hemopoiesis [GO:0060216]; determination of left/right symmetry [GO:0007368]; developmental pigmentation [GO:0048066]; diencephalon development [GO:0021536]; digestive tract morphogenesis [GO:0048546]; embryonic camera-type eye development [GO:0031076]; embryonic pattern specification [GO:0009880]; endocytosis [GO:0006897]; endothelial cell development [GO:0001885]; epidermal cell differentiation [GO:0009913]; epithelial cell development [GO:0002064]; floor plate formation [GO:0021508]; formation of anatomical boundary [GO:0048859]; generation of neurons [GO:0048699]; glial cell differentiation [GO:0010001]; habenula development [GO:0021986]; hair cell differentiation [GO:0035315]; heart development [GO:0007507]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell differentiation [GO:0060218]; hemopoiesis [GO:0030097]; hindbrain development [GO:0030902]; inner ear receptor cell differentiation [GO:0060113]; lateral line nerve development [GO:0048892]; melanocyte differentiation [GO:0030318]; neural retina development [GO:0003407]; neurogenesis [GO:0022008]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; Notch signaling pathway [GO:0007219]; notochord cell development [GO:0060035]; notochord development [GO:0030903]; optic cup formation involved in camera-type eye development [GO:0003408]; otic vesicle development [GO:0071599]; pigment cell differentiation [GO:0050931]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of protein ubiquitination [GO:0031398]; posterior lateral line development [GO:0048916]; posterior lateral line neuromast primordium migration [GO:0048920]; pronephric duct development [GO:0039022]; pronephros development [GO:0048793]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; regulation of glial cell differentiation [GO:0045685]; regulation of neuron differentiation [GO:0045664]; regulation of Notch signaling pathway [GO:0008593]; regulation of receptor internalization [GO:0002090]; regulation of receptor-mediated endocytosis [GO:0048259]; rhombomere boundary formation [GO:0021654]; rhombomere development [GO:0021546]; somitogenesis [GO:0001756]; spinal cord association neuron specification [GO:0021519]; spinal cord development [GO:0021510]; spinal cord motor neuron cell fate specification [GO:0021520]; sprouting angiogenesis [GO:0002040]; taste bud formation [GO:0061195]; trigeminal ganglion development [GO:0061551]; ubiquitin-dependent endocytosis [GO:0070086]; vasculogenesis [GO:0001570]; ventral spinal cord interneuron differentiation [GO:0021514]; ventral spinal cord interneuron specification [GO:0021521]	identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; endocytic vesicle [GO:0030139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0001568; GO:0001570; GO:0001756; GO:0001885; GO:0002040; GO:0002064; GO:0002090; GO:0002244; GO:0003407; GO:0003408; GO:0004842; GO:0005737; GO:0005886; GO:0006897; GO:0007219; GO:0007368; GO:0007417; GO:0007420; GO:0007507; GO:0008270; GO:0008284; GO:0008593; GO:0009880; GO:0009913; GO:0010001; GO:0016567; GO:0021508; GO:0021510; GO:0021514; GO:0021519; GO:0021520; GO:0021521; GO:0021536; GO:0021546; GO:0021654; GO:0021986; GO:0022008; GO:0030097; GO:0030139; GO:0030182; GO:0030318; GO:0030902; GO:0030903; GO:0031076; GO:0031398; GO:0031410; GO:0032991; GO:0034451; GO:0035315; GO:0039022; GO:0042802; GO:0045664; GO:0045685; GO:0045747; GO:0048066; GO:0048259; GO:0048471; GO:0048514; GO:0048546; GO:0048663; GO:0048665; GO:0048666; GO:0048699; GO:0048793; GO:0048859; GO:0048892; GO:0048899; GO:0048916; GO:0048920; GO:0050931; GO:0051865; GO:0060035; GO:0060113; GO:0060216; GO:0060218; GO:0061195; GO:0061551; GO:0061630; GO:0070086; GO:0071599
GN017222	GN017222.1	B1WB06	30.4	184	334	353	4.45e-12	69.7	MET24_XENTR	Probable methyltransferase-like protein 24 (EC 2.1.1.-)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			extracellular region [GO:0005576]	GO:0005576
GN017223	GN017223.1	Q8NBP0	41.4	676	797	860	7.24e-139	434	TTC13_HUMAN	Tetratricopeptide repeat protein 13 (TPR repeat protein 13)	Homo sapiens (Human)				
GN017224	GN017224.1	O42281	26.5	344	385	354	1.78e-38	144	PRPH2_CHICK	Peripherin-2 (CRDS1) (Photoreceptor outer segment membrane glycoprotein 1) (Retinal degeneration slow protein)	Gallus gallus (Chicken)	protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]	protein homodimerization activity [GO:0042803]	membrane [GO:0016020]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]	GO:0001750; GO:0005886; GO:0007601; GO:0016020; GO:0042803; GO:0051604; GO:0060041; GO:0072659
GN017225	GN017225.1	L7YAI7	38.5	358	364	431	1.65e-76	245	B4GA1_DANRE	Beta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) (N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	glycoprotein biosynthetic process [GO:0009101]; muscle cell development [GO:0055001]; protein O-linked glycosylation via mannose [GO:0035269]	glucuronosyltransferase activity [GO:0015020]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005794; GO:0009101; GO:0015020; GO:0035269; GO:0055001
GN017226	GN017226.1	Q5ZMT7	56.0	464	516	519	1.21e-188	540	ADCK1_CHICK	AarF domain-containing protein kinase 1 (EC 2.7.-.-)	Gallus gallus (Chicken)	lipid homeostasis [GO:0055088]; mitochondrion organization [GO:0007005]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0004672; GO:0005524; GO:0005739; GO:0005743; GO:0007005; GO:0055088
GN017227	GN017227.1	Q5R7R9	67.7	507	502	536	1.83e-220	621	SNW1_PONAB	SNW domain-containing protein 1 (Nuclear protein SkiP) (Ski-interacting protein)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; regulation of vitamin D receptor signaling pathway [GO:0070562]; retinoic acid receptor signaling pathway [GO:0048384]	nuclear receptor binding [GO:0016922]; nuclear retinoic acid receptor binding [GO:0042974]; nuclear vitamin D receptor binding [GO:0042809]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	nuclear matrix [GO:0016363]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000122; GO:0000398; GO:0003713; GO:0003714; GO:0005634; GO:0016363; GO:0016922; GO:0030511; GO:0042771; GO:0042809; GO:0042974; GO:0045944; GO:0046332; GO:0048026; GO:0048384; GO:0048385; GO:0050769; GO:0070562; GO:0071007
GN017229	GN017229.1	Q05974	60.5	200	201	205	6.01e-81	242	RAB1A_LYMST	Ras-related protein Rab-1A	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]	GO:0003924; GO:0005525; GO:0005783; GO:0005794
GN017231	GN017231.1	Q8WSR7	33.1	154	154	254	7.39e-19	83.2	CTNB_DICDI	Countin-2	Dictyostelium discoideum (Social amoeba)	aggregation involved in sorocarp development [GO:0031152]; cell-cell adhesion [GO:0098609]		extracellular region [GO:0005576]	GO:0005576; GO:0031152; GO:0098609
GN017233	GN017233.1	Q9UBT6	41.7	873	910	870	1.03e-175	534	POLK_HUMAN	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP)	Homo sapiens (Human)	cellular response to UV [GO:0034644]; DNA biosynthetic process [GO:0071897]; DNA damage response [GO:0006974]; DNA repair [GO:0006281]; error-prone translesion synthesis [GO:0042276]; nucleotide-excision repair, DNA gap filling [GO:0006297]; translesion synthesis [GO:0019985]	damaged DNA binding [GO:0003684]; DNA polymerase activity [GO:0034061]; DNA-directed DNA polymerase activity [GO:0003887]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0003684; GO:0003887; GO:0005634; GO:0005654; GO:0006281; GO:0006297; GO:0006974; GO:0019985; GO:0034061; GO:0034644; GO:0042276; GO:0071897; GO:0090734
GN017234	GN017234.1	Q6VVX2	55.4	594	597	598	1.54e-217	620	CERT_CRIGR	Ceramide transfer protein (CERT) (Collagen type IV alpha-3-binding protein)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	ER to Golgi ceramide transport [GO:0035621]	ceramide transfer activity [GO:0120017]; phosphatidylinositol-4-phosphate binding [GO:0070273]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]	GO:0005783; GO:0005794; GO:0005829; GO:0035621; GO:0070273; GO:0120017
GN017238	GN017238.1	P51949	48.4	281	287	309	1.13e-77	241	MAT1_MOUSE	CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Menage a trois) (RING finger protein MAT1) (p35) (p36)	Mus musculus (Mouse)	adult heart development [GO:0007512]; DNA repair [GO:0006281]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of apoptotic process [GO:0043066]; nucleotide-excision repair [GO:0006289]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of DNA-templated transcription [GO:0006355]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of transcription by RNA polymerase II [GO:0006357]; response to calcium ion [GO:0051592]; transcription initiation at RNA polymerase II promoter [GO:0006367]; ventricular system development [GO:0021591]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]	CAK-ERCC2 complex [GO:0070516]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; nucleoplasm [GO:0005654]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; transcription factor TFIIK complex [GO:0070985]	GO:0000082; GO:0000307; GO:0000439; GO:0005654; GO:0005675; GO:0006281; GO:0006289; GO:0006355; GO:0006357; GO:0006367; GO:0007512; GO:0021591; GO:0043066; GO:0048661; GO:0051592; GO:0061575; GO:0070516; GO:0070985; GO:2000045
GN017239	GN017239.1	Q8IWV8	51.8	336	368	1755	7.01e-104	338	UBR2_HUMAN	E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II)	Homo sapiens (Human)	cellular response to L-leucine [GO:0071233]; heterochromatin formation [GO:0031507]; male meiotic nuclear division [GO:0007140]; negative regulation of TOR signaling [GO:0032007]; positive regulation of T cell receptor signaling pathway [GO:0050862]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]; transposable element silencing [GO:0010526]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596]	histone H2A ubiquitin ligase activity [GO:0141053]; L-leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000785; GO:0005634; GO:0005694; GO:0005737; GO:0005829; GO:0007131; GO:0007140; GO:0007283; GO:0008270; GO:0010526; GO:0016567; GO:0031507; GO:0032007; GO:0043161; GO:0050862; GO:0061630; GO:0070534; GO:0070728; GO:0071233; GO:0071596; GO:0141053
GN017240	GN017240.1	Q61321	76.1	176	256	775	8.07e-91	287	SIX4_MOUSE	Homeobox protein SIX4 (Sine oculis homeobox homolog 4) (Skeletal muscle-specific ARE-binding protein AREC3)	Mus musculus (Mouse)	embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic skeletal system morphogenesis [GO:0048704]; fungiform papilla morphogenesis [GO:0061197]; generation of neurons [GO:0048699]; inner ear morphogenesis [GO:0042472]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; male sex differentiation [GO:0046661]; metanephric mesenchyme development [GO:0072075]; myoblast migration [GO:0051451]; myotome development [GO:0061055]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of satellite cell differentiation [GO:1902725]; olfactory placode formation [GO:0030910]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of epithelial cell proliferation [GO:0050678]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of transcription by RNA polymerase II [GO:0006357]; sarcomere organization [GO:0045214]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; tongue development [GO:0043586]; trigeminal ganglion development [GO:0061551]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000978; GO:0000981; GO:0001228; GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0005737; GO:0006357; GO:0007519; GO:0008582; GO:0008584; GO:0010468; GO:0030238; GO:0030910; GO:0032880; GO:0034504; GO:0042472; GO:0043066; GO:0043524; GO:0043565; GO:0043586; GO:0045214; GO:0045892; GO:0045893; GO:0045944; GO:0046661; GO:0048538; GO:0048699; GO:0048701; GO:0048704; GO:0050678; GO:0051451; GO:0060037; GO:0061055; GO:0061197; GO:0061551; GO:0072075; GO:0072095; GO:0072107; GO:0090190; GO:0098528; GO:1902725; GO:1990837
GN017242	GN017242.1	Q7L0Q8	65.3	222	247	258	9.16e-95	281	RHOU_HUMAN	Rho-related GTP-binding protein RhoU (EC 3.6.5.2) (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)	Homo sapiens (Human)	actin filament organization [GO:0007015]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010]; positive regulation of focal adhesion disassembly [GO:0120183]; positive regulation of protein localization to mitochondrion [GO:1903749]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; podosome [GO:0002102]	GO:0000139; GO:0002102; GO:0003925; GO:0005085; GO:0005525; GO:0005829; GO:0005886; GO:0005925; GO:0006897; GO:0007015; GO:0007264; GO:0008360; GO:0010008; GO:0019901; GO:0030010; GO:0030674; GO:0051056; GO:0120183; GO:1903749
GN017243	GN017243.1	A3KMW7	25.0	549	949	912	1.49e-09	65.9	MAP10_BOVIN	Microtubule-associated protein 10 (Microtubule regulator of 120 KDa)	Bos taurus (Bovine)	cytoplasmic microtubule organization [GO:0031122]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cytokinesis [GO:0032467]; regulation of microtubule-based process [GO:0032886]	microtubule binding [GO:0008017]	centrosome [GO:0005813]; cytoplasmic microtubule [GO:0005881]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]	GO:0005813; GO:0005881; GO:0008017; GO:0030496; GO:0031122; GO:0032467; GO:0032886; GO:0051256; GO:0097431; GO:1990023
GN017244	GN017244.1	Q9H477	50.9	289	320	322	6.94e-91	276	RBSK_HUMAN	Ribokinase (RK) (EC 2.7.1.15)	Homo sapiens (Human)	carbohydrate phosphorylation [GO:0046835]; D-ribose catabolic process [GO:0019303]; pentose-phosphate shunt [GO:0006098]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; ribokinase activity [GO:0004747]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004747; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006098; GO:0019303; GO:0042802; GO:0046835
GN017245	GN017245.1	A7S8T5	29.8	262	352	312	7.89e-18	86.3	CCD42_NEMVE	Coiled-coil domain-containing protein 42 homolog	Nematostella vectensis (Starlet sea anemone)			cytoskeleton [GO:0005856]	GO:0005856
GN017250	GN017250.1	Q9VZI3	46.0	682	774	708	4.97e-184	545	UN112_DROME	Unc-112-related protein (Fermitin-1)	Drosophila melanogaster (Fruit fly)	cardiac muscle tissue development [GO:0048738]; cell-matrix adhesion [GO:0007160]; defense response to Gram-negative bacterium [GO:0050829]; integrin-mediated signaling pathway [GO:0007229]	cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]	cell-substrate junction [GO:0030055]; cytoplasm [GO:0005737]	GO:0005178; GO:0005737; GO:0007160; GO:0007229; GO:0030055; GO:0048738; GO:0050829; GO:0050839
GN017251	GN017251.1	Q96AC1	57.1	42	55	680	1.21e-09	54.7	FERM2_HUMAN	Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)	Homo sapiens (Human)	adherens junction maintenance [GO:0034334]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; focal adhesion assembly [GO:0048041]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; limb development [GO:0060173]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of vascular permeability [GO:0043116]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of integrin activation [GO:0033625]; positive regulation of mesenchymal stem cell proliferation [GO:1902462]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of wound healing, spreading of epidermal cells [GO:1903691]; protein localization to cell junction [GO:1902414]; protein localization to membrane [GO:0072657]; regulation of cell morphogenesis [GO:0022604]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway [GO:0016055]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; integrin binding [GO:0005178]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase binding [GO:0120283]; SMAD binding [GO:0046332]; type I transforming growth factor beta receptor binding [GO:0034713]	adherens junction [GO:0005912]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; I band [GO:0031674]; lamellipodium membrane [GO:0031258]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]	GO:0001725; GO:0003779; GO:0005178; GO:0005547; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0005912; GO:0005925; GO:0005938; GO:0007155; GO:0007160; GO:0007179; GO:0007229; GO:0009898; GO:0009986; GO:0010718; GO:0016055; GO:0019901; GO:0022604; GO:0030054; GO:0030335; GO:0031258; GO:0031674; GO:0033622; GO:0033625; GO:0034334; GO:0034446; GO:0034713; GO:0035025; GO:0043116; GO:0043539; GO:0045599; GO:0045669; GO:0046332; GO:0048041; GO:0051015; GO:0051496; GO:0051894; GO:0051897; GO:0060173; GO:0070374; GO:0072657; GO:0120283; GO:1900026; GO:1900182; GO:1902414; GO:1902462; GO:1903691
GN017253	GN017253.1	A4IF87	36.9	561	567	680	4.57e-116	362	GNPAT_BOVIN	Dihydroxyacetone phosphate acyltransferase (EC 2.3.1.42) (Glycerone-phosphate O-acyltransferase)	Bos taurus (Bovine)	ether lipid biosynthetic process [GO:0008611]; glycerophospholipid metabolic process [GO:0006650]	glycerone-phosphate O-acyltransferase activity [GO:0016287]	peroxisomal membrane [GO:0005778]	GO:0005778; GO:0006650; GO:0008611; GO:0016287
GN017254	GN017254.1	P95125	34.5	142	183	376	1.57e-16	79.3	LIPN_MYCTU	Carboxylic ester hydrolase LipN (EC 3.1.1.-)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)		acetylesterase activity [GO:0008126]; carboxylesterase activity [GO:0106435]; short-chain carboxylesterase activity [GO:0034338]; triacylglycerol lipase activity [GO:0004806]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004806; GO:0005737; GO:0005886; GO:0008126; GO:0034338; GO:0106435
GN017256	GN017256.1	Q9H4B6	61.3	186	668	383	1.27e-42	161	SAV1_HUMAN	Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45)	Homo sapiens (Human)	apoptotic process [GO:0006915]; hippo signaling [GO:0035329]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; protein stabilization [GO:0050821]	identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; protein serine/threonine kinase activator activity [GO:0043539]; transcription regulator activator activity [GO:0140537]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0008285; GO:0035329; GO:0042802; GO:0043065; GO:0043539; GO:0050821; GO:0060090; GO:0140537
GN017257	GN017257.1	Q5TD94	55.8	491	526	716	1.85e-165	489	RSH4A_HUMAN	Radial spoke head protein 4 homolog A (Radial spoke head-like protein 3)	Homo sapiens (Human)	axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; radial spoke assembly [GO:0062177]		9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; cilium [GO:0005929]; motile cilium [GO:0031514]; radial spoke [GO:0001534]; radial spoke head [GO:0001535]; radial spoke head 1 [GO:0120336]; radial spoke head 2 [GO:0120337]; radial spoke head 3 [GO:0120338]	GO:0001534; GO:0001535; GO:0003341; GO:0005929; GO:0005930; GO:0031514; GO:0035082; GO:0060294; GO:0062177; GO:0097729; GO:0120336; GO:0120337; GO:0120338
GN017259	GN017259.1	Q29RQ5	46.9	736	726	710	5.01e-232	666	TRIM9_BOVIN	E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9)	Bos taurus (Bovine)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dendrite [GO:0030425]; synaptic vesicle [GO:0008021]	GO:0005737; GO:0005856; GO:0008021; GO:0008270; GO:0016567; GO:0030425; GO:0043161; GO:0061630
GN017260	GN017260.1	A7SMW7	64.2	335	352	456	7.69e-151	435	L2HDH_NEMVE	L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2)	Nematostella vectensis (Starlet sea anemone)		(S)-2-hydroxyglutarate dehydrogenase activity [GO:0047545]	mitochondrion [GO:0005739]	GO:0005739; GO:0047545
GN017261	GN017261.1	Q9Y600	56.9	367	366	493	1.68e-157	454	CSAD_HUMAN	Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Aspartate 1-decarboxylase) (EC 4.1.1.11) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase)	Homo sapiens (Human)	L-cysteine catabolic process [GO:0019448]; taurine biosynthetic process [GO:0042412]	aspartate 1-decarboxylase activity [GO:0004068]; pyridoxal phosphate binding [GO:0030170]; sulfinoalanine decarboxylase activity [GO:0004782]	cytoplasm [GO:0005737]	GO:0004068; GO:0004782; GO:0005737; GO:0019448; GO:0030170; GO:0042412
GN017262	GN017262.1	Q96BY7	31.1	164	218	2078	9.36e-14	73.2	ATG2B_HUMAN	Autophagy-related protein 2 homolog B	Homo sapiens (Human)	autophagy of mitochondrion [GO:0000422]; glycophagy [GO:0061723]; pexophagy [GO:0000425]; piecemeal microautophagy of the nucleus [GO:0034727]; reticulophagy [GO:0061709]	lipid transfer activity [GO:0120013]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein-membrane adaptor activity [GO:0043495]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]; phagophore [GO:0061908]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]	GO:0000407; GO:0000422; GO:0000425; GO:0005783; GO:0005789; GO:0005811; GO:0032266; GO:0034045; GO:0034727; GO:0043495; GO:0061709; GO:0061723; GO:0061908; GO:0120013
GN017264	GN017264.1	Q6AXL3	23.4	500	889	685	8.39e-12	72.8	LRC33_DANRE	Transforming growth factor beta activator LRRC33 (Leucine-rich repeat-containing protein 33) (Negative regulator of reactive oxygen species)	Danio rerio (Zebrafish) (Brachydanio rerio)	immune response [GO:0006955]; inflammatory response [GO:0006954]; microglia development [GO:0014005]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]	receptor ligand inhibitor activity [GO:0141069]; signaling receptor activity [GO:0038023]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0005783; GO:0005789; GO:0005886; GO:0006954; GO:0006955; GO:0009986; GO:0014005; GO:0030511; GO:0038023; GO:0141069
GN017265	GN017265.1	Q22795	37.6	141	975	242	1.41e-22	101	KMT5A_CAEEL	Histone-lysine N-methyltransferase set-1 (EC 2.1.1.361)	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of transcription by RNA polymerase II [GO:0006357]	histone H4K20 methyltransferase activity [GO:0042799]; histone H4K20 monomethyltransferase activity [GO:0140944]; RNA binding [GO:0003723]	nucleus [GO:0005634]; polytene chromosome [GO:0005700]; Set1C/COMPASS complex [GO:0048188]	GO:0003723; GO:0005634; GO:0005700; GO:0006357; GO:0009792; GO:0042799; GO:0043516; GO:0048188; GO:0140944
GN017267	GN017267.1	Q9Y664	44.1	59	166	436	6.32e-10	60.1	KPTN_HUMAN	KICSTOR complex protein kaptin (Actin-associated protein 2E4)	Homo sapiens (Human)	actin filament organization [GO:0007015]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose starvation [GO:0042149]; negative regulation of TORC1 signaling [GO:1904262]; protein localization to lysosome [GO:0061462]	actin filament binding [GO:0051015]	KICSTOR complex [GO:0140007]; lamellipodium [GO:0030027]; lysosomal membrane [GO:0005765]; postsynaptic actin cytoskeleton [GO:0098871]; stereocilium [GO:0032420]	GO:0005765; GO:0007015; GO:0030027; GO:0032420; GO:0034198; GO:0042149; GO:0051015; GO:0061462; GO:0098871; GO:0140007; GO:1904262
GN017268	GN017268.1	Q6DDB9	65.9	126	160	236	1.64e-49	162	PNO1_XENTR	RNA-binding protein PNO1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	ribosomal small subunit biogenesis [GO:0042274]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]	GO:0003723; GO:0005634; GO:0005730; GO:0032040; GO:0042274
GN017270	GN017270.1	Q80UF4	27.8	697	753	717	2.10e-61	223	SDCG8_MOUSE	Serologically defined colon cancer antigen 8 homolog (Centrosomal colon cancer autoantigen protein) (mCCCAP)	Mus musculus (Mouse)	centrosome cycle [GO:0007098]; establishment of cell polarity [GO:0030010]; microtubule organizing center organization [GO:0031023]; neuron migration [GO:0001764]; regulation of cilium assembly [GO:1902017]; tube formation [GO:0035148]		anchoring junction [GO:0070161]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; photoreceptor cell cilium [GO:0097733]	GO:0001764; GO:0005654; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0005911; GO:0005929; GO:0007098; GO:0030010; GO:0031023; GO:0034451; GO:0035148; GO:0036064; GO:0070161; GO:0097733; GO:1902017
GN017273	GN017273.1	H9JW44	33.1	357	1026	364	1.77e-48	180	CDA7_BOMMO	Chitin deacetylase 7 (BmCDA7) (EC 3.5.1.41)	Bombyx mori (Silk moth)	polysaccharide catabolic process [GO:0000272]	chitin deacetylase activity [GO:0004099]	extracellular region [GO:0005576]	GO:0000272; GO:0004099; GO:0005576
GN017274	GN017274.1	H9J9M0	32.9	331	641	539	3.28e-48	180	CDA1_BOMMO	Chitin deacetylase 1 (BmCDA1) (EC 3.5.1.41)	Bombyx mori (Silk moth)	polysaccharide catabolic process [GO:0000272]	chitin binding [GO:0008061]; chitin deacetylase activity [GO:0004099]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0000272; GO:0004099; GO:0005576; GO:0008061; GO:0008270
GN017277	GN017277.1	Q9NRW7	63.5	208	207	570	6.96e-86	267	VPS45_HUMAN	Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45)	Homo sapiens (Human)	intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]		endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; synaptic vesicle [GO:0008021]	GO:0000139; GO:0005794; GO:0006886; GO:0008021; GO:0010008; GO:0016020; GO:0016192
GN017278	GN017278.1	Q4I963	38.4	159	161	153	7.57e-30	109	COFI_GIBZE	Cofilin (Actin-depolymerizing factor 1)	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)	actin filament depolymerization [GO:0030042]	actin binding [GO:0003779]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]	GO:0003779; GO:0005737; GO:0015629; GO:0016363; GO:0030042
GN017281	GN017281.1	P08478	50.2	333	369	935	1.76e-92	299	AMDA_XENLA	Peptidyl-glycine alpha-amidating monooxygenase A (PAM-A) (Peptide C-terminal alpha-amidating enzyme I) (AE-I) (Peptidyl-glycine alpha-amidating monooxygenase I) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase A (PHM-A) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase A (EC 4.3.2.5) (Peptidylamidoglycolate lyase-A) (PAL-A)]	Xenopus laevis (African clawed frog)	peptide amidation [GO:0001519]	copper ion binding [GO:0005507]; peptidylamidoglycolate lyase activity [GO:0004598]; peptidylglycine monooxygenase activity [GO:0004504]	extracellular region [GO:0005576]; transport vesicle membrane [GO:0030658]	GO:0001519; GO:0004504; GO:0004598; GO:0005507; GO:0005576; GO:0030658
GN017282	GN017282.1	Q96B67	32.0	281	364	414	6.80e-40	149	ARRD3_HUMAN	Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)	Homo sapiens (Human)	negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of hippo signaling [GO:0035332]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]	beta-3 adrenergic receptor binding [GO:0031699]; molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0031699; GO:0035332; GO:0051443; GO:0060090; GO:0120163
GN017283	GN017283.1	Q9VFJ2	48.2	195	200	196	4.07e-52	169	RM11_DROME	Large ribosomal subunit protein uL11m (39S ribosomal protein L11, mitochondrial) (L11mt) (MRP-L11)	Drosophila melanogaster (Fruit fly)	mitochondrial translation [GO:0032543]; translation [GO:0006412]	large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735]	mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005762; GO:0006412; GO:0032543; GO:0070180
GN017284	GN017284.1	Q68DK2	30.2	1375	3171	2539	1.12e-155	546	ZFY26_HUMAN	Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin)	Homo sapiens (Human)	autophagosome organization [GO:1905037]; double-strand break repair via homologous recombination [GO:0000724]; lysosomal membrane organization [GO:0097212]; lysosome organization [GO:0007040]; membrane bending [GO:0097753]; mitotic cytokinesis [GO:0000281]; regulation of cytokinesis [GO:0032465]	identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein kinase binding [GO:0019901]	centrosome [GO:0005813]; early endosome [GO:0005769]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; midbody [GO:0030496]	GO:0000281; GO:0000724; GO:0005764; GO:0005765; GO:0005769; GO:0005770; GO:0005813; GO:0007040; GO:0019901; GO:0030496; GO:0032266; GO:0032465; GO:0042802; GO:0046872; GO:0097212; GO:0097753; GO:1905037
GN017285	GN017285.1	A0A1L8ER70	32.3	300	308	331	1.65e-19	90.5	HYLS1_XENLA	Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1 homolog)	Xenopus laevis (African clawed frog)	cilium assembly [GO:0060271]		centriole [GO:0005814]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; non-motile cilium [GO:0097730]	GO:0005814; GO:0005929; GO:0036064; GO:0060271; GO:0097730
GN017286	GN017286.1	P62862	62.8	129	134	133	1.96e-46	149	RS30_MOUSE	Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein (FAU ubiquitin-like and ribosomal protein S30) [Cleaved into: Ubiquitin-like protein FUBI; Small ribosomal subunit protein eS30 (40S ribosomal protein S30)]	Mus musculus (Mouse)	antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; modification-dependent protein catabolic process [GO:0019941]; protein ubiquitination [GO:0016567]; ribosomal small subunit assembly [GO:0000028]	protein tag activity [GO:0031386]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0000028; GO:0002181; GO:0002227; GO:0003735; GO:0005576; GO:0005634; GO:0005730; GO:0005737; GO:0005783; GO:0005829; GO:0016567; GO:0019731; GO:0019941; GO:0022626; GO:0022627; GO:0031386; GO:0050830; GO:0061844
GN017288	GN017288.1	Q32PI6	47.5	177	293	294	5.94e-45	157	RM04_BOVIN	Large ribosomal subunit protein uL4m (39S ribosomal protein L4, mitochondrial) (L4mt) (MRP-L4)	Bos taurus (Bovine)	positive regulation of Notch signaling pathway [GO:0045747]; regulation of translation [GO:0006417]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005762; GO:0006412; GO:0006417; GO:0045747
GN017289	GN017289.1	Q14318	48.5	66	245	412	2.75e-10	63.2	FKBP8_HUMAN	Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; protein folding [GO:0006457]; protein localization to mitochondrion [GO:0070585]; regulation of mitophagy [GO:1901524]	calmodulin binding [GO:0005516]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding chaperone [GO:0044183]	cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial envelope [GO:0005740]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	GO:0001933; GO:0003755; GO:0005516; GO:0005739; GO:0005740; GO:0005789; GO:0005829; GO:0006457; GO:0012505; GO:0016020; GO:0031966; GO:0032991; GO:0035556; GO:0042802; GO:0043066; GO:0044183; GO:0070585; GO:0097718; GO:1901524
GN017290	GN017290.1	Q05AT9	62.0	166	242	272	3.21e-72	224	U1SBP_XENLA	U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12 snRNP 35 kDa protein) (U1 snRNP-binding protein homolog)	Xenopus laevis (African clawed frog)	mRNA splicing, via spliceosome [GO:0000398]	mRNA binding [GO:0003729]; snRNA binding [GO:0017069]	precatalytic spliceosome [GO:0071011]; U12-type spliceosomal complex [GO:0005689]	GO:0000398; GO:0003729; GO:0005689; GO:0017069; GO:0071011
GN017293	GN017293.1	Q62634	37.1	412	635	560	1.95e-85	281	VGLU1_RAT	Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7)	Rattus norvegicus (Rat)	chemical synaptic transmission [GO:0007268]; chloride transport [GO:0006821]; excitatory postsynaptic potential [GO:0060079]; L-glutamate import [GO:0051938]; L-glutamate transmembrane transport [GO:0015813]; long-term memory [GO:0007616]; neural retina development [GO:0003407]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter uptake [GO:0001504]; phosphate ion homeostasis [GO:0055062]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; potassium ion transport [GO:0006813]; regulation of synapse structure or activity [GO:0050803]; regulation of synaptic vesicle endocytosis [GO:1900242]; sodium-dependent phosphate transport [GO:0044341]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle lumen acidification [GO:0097401]	chloride channel activity [GO:0005254]; extracellularly glutamate-gated chloride channel activity [GO:0008068]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamate uniporter activity [GO:0140788]; neurotransmitter transmembrane transporter activity [GO:0005326]; phosphate ion uniporter activity [GO:0140787]; potassium:proton antiporter activity [GO:0015386]; sodium:phosphate symporter activity [GO:0005436]	cerebellar mossy fiber [GO:0044300]; excitatory synapse [GO:0060076]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic active zone [GO:0048786]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	GO:0001504; GO:0003407; GO:0005254; GO:0005313; GO:0005326; GO:0005436; GO:0005886; GO:0006813; GO:0006817; GO:0006821; GO:0007268; GO:0007616; GO:0008021; GO:0008068; GO:0015386; GO:0015813; GO:0016020; GO:0030672; GO:0035249; GO:0035435; GO:0044300; GO:0044341; GO:0045202; GO:0048786; GO:0050803; GO:0051938; GO:0055062; GO:0060076; GO:0060079; GO:0097401; GO:0098700; GO:0098794; GO:0140787; GO:0140788; GO:1900242
GN017294	GN017294.1	P24367	68.8	202	209	207	6.62e-97	283	PPIB_CHICK	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	Gallus gallus (Chicken)	negative regulation of collagen fibril organization [GO:1904027]; protein folding [GO:0006457]	cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]; protein-containing complex [GO:0032991]	GO:0003755; GO:0005788; GO:0006457; GO:0016018; GO:0032991; GO:0042470; GO:1904027
GN017298	GN017298.1	Q99853	44.7	219	337	325	6.57e-52	177	FOXB1_HUMAN	Forkhead box protein B1 (Transcription factor FKH-5)	Homo sapiens (Human)	anatomical structure morphogenesis [GO:0009653]; axon target recognition [GO:0007412]; cell differentiation [GO:0030154]; cell migration in diencephalon [GO:0061381]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; floor plate development [GO:0033504]; hypothalamus cell migration [GO:0021855]; inferior colliculus development [GO:0061379]; lactation [GO:0007595]; mammary gland lobule development [GO:0061377]; mammillary body development [GO:0021767]; mammillothalamic axonal tract development [GO:0061374]; midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of transcription by RNA polymerase II [GO:0006357]; somitogenesis [GO:0001756]; spinal cord development [GO:0021510]; telencephalon cell migration [GO:0022029]; thalamus development [GO:0021794]; urogenital system development [GO:0001655]; visual learning [GO:0008542]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001655; GO:0001756; GO:0005634; GO:0006357; GO:0007412; GO:0007595; GO:0008542; GO:0009653; GO:0021510; GO:0021767; GO:0021794; GO:0021855; GO:0022029; GO:0030154; GO:0030901; GO:0033504; GO:0043524; GO:0043565; GO:0061030; GO:0061374; GO:0061377; GO:0061379; GO:0061381; GO:1990837
GN017299	GN017299.1	Q9CR78	37.6	133	178	275	3.93e-19	85.1	MSD3_MOUSE	Myb/SANT-like DNA-binding domain-containing protein 3	Mus musculus (Mouse)				
GN017301	GN017301.1	Q5HZI2	26.3	490	540	419	2.45e-19	94.0	C2C4C_MOUSE	C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C)	Mus musculus (Mouse)			cytosol [GO:0005829]	GO:0005829
GN017320	GN017320.1	P18910	36.5	950	1069	1057	1.90e-183	565	ANPRA_RAT	Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)	Rattus norvegicus (Rat)	cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	ANPR-A receptor complex [GO:1990620]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005789; GO:0005886; GO:0006182; GO:0007166; GO:0007168; GO:0008217; GO:0016020; GO:0016941; GO:0017046; GO:0031965; GO:0035556; GO:0042417; GO:0042562; GO:0043114; GO:0043235; GO:0048662; GO:1990620
GN017321	GN017321.1	Q7SXS7	51.4	455	505	596	5.22e-157	462	SETD3_DANRE	Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3)	Danio rerio (Zebrafish) (Brachydanio rerio)	actin filament organization [GO:0007015]; cell population proliferation [GO:0008283]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell growth [GO:0001558]; regulation of uterine smooth muscle contraction [GO:0070472]	histone H3K36 methyltransferase activity [GO:0046975]; histone H3K4 methyltransferase activity [GO:0042800]; protein-L-histidine N-tele-methyltransferase activity [GO:0018064]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]	GO:0001558; GO:0003713; GO:0005737; GO:0007015; GO:0008283; GO:0018064; GO:0042800; GO:0045893; GO:0045944; GO:0046975; GO:0070472
GN017322	GN017322.1	F1QMB9	67.5	123	459	425	3.26e-49	176	CCNK_DANRE	Cyclin-K	Danio rerio (Zebrafish) (Brachydanio rerio)	central nervous system development [GO:0007417]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]	cyclin-dependent protein serine/threonine kinase activator activity [GO:0061575]	cyclin/CDK positive transcription elongation factor complex [GO:0008024]; nucleus [GO:0005634]	GO:0005634; GO:0007417; GO:0008024; GO:0032786; GO:0045944; GO:0061575
GN017323	GN017323.1	Q9SHU5	35.0	137	172	205	9.16e-14	69.3	ARF4_ARATH	Probable ADP-ribosylation factor At2g15310	Arabidopsis thaliana (Mouse-ear cress)	intracellular protein transport [GO:0006886]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phospholipase activator activity [GO:0016004]	Golgi apparatus [GO:0005794]	GO:0003924; GO:0005525; GO:0005794; GO:0006886; GO:0016004
GN017325	GN017325.1	Q9VEC1	43.3	434	431	642	2.76e-97	307	MED17_DROME	Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17) (dMED17) (dTRAP80)	Drosophila melanogaster (Fruit fly)	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription initiation by RNA polymerase II [GO:0060260]; sex comb development [GO:0045498]	DNA-binding transcription factor binding [GO:0140297]; transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	GO:0003712; GO:0005634; GO:0005721; GO:0006357; GO:0016592; GO:0045498; GO:0045893; GO:0045944; GO:0060260; GO:0070847; GO:0140297
GN017326	GN017326.1	Q5HZQ9	39.6	1246	1238	1184	1.04e-274	811	PCX4_XENLA	Pecanex-like protein 4 (Pecanex homolog protein 4)	Xenopus laevis (African clawed frog)			membrane [GO:0016020]	GO:0016020
GN017327	GN017327.1	Q8CEE7	52.6	312	321	334	5.87e-98	295	RDH13_MOUSE	Retinol dehydrogenase 13 (EC 1.1.1.300)	Mus musculus (Mouse)	eye photoreceptor cell development [GO:0042462]; response to high light intensity [GO:0009644]; retina layer formation [GO:0010842]; retinal metabolic process [GO:0042574]	all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0009644; GO:0010842; GO:0042462; GO:0042574; GO:0052650
GN017331	GN017331.1	M9MRD1	27.8	3487	3501	12345	0.0	1483	MS300_DROME	Muscle-specific protein 300 kDa (Nesprin-like protein Msp300)	Drosophila melanogaster (Fruit fly)	actin filament organization [GO:0007015]; cell migration [GO:0016477]; endoplasmic reticulum localization [GO:0051643]; female germline ring canal stabilization [GO:0008335]; flight [GO:0060361]; larval visceral muscle development [GO:0007523]; locomotion [GO:0040011]; mesoderm development [GO:0007498]; microtubule anchoring [GO:0034453]; mitochondrion localization [GO:0051646]; nuclear migration [GO:0007097]; nucleus localization [GO:0051647]; nucleus organization [GO:0006997]; ovarian nurse cell to oocyte transport [GO:0007300]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; meiotic nuclear membrane microtubule tethering complex [GO:0034993]; microtubule organizing center [GO:0005815]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear outer membrane [GO:0005640]; perinuclear region of cytoplasm [GO:0048471]; Z disc [GO:0030018]	GO:0003779; GO:0005635; GO:0005640; GO:0005737; GO:0005815; GO:0006997; GO:0007015; GO:0007097; GO:0007300; GO:0007498; GO:0007523; GO:0008335; GO:0016477; GO:0019901; GO:0030018; GO:0031965; GO:0034453; GO:0034993; GO:0040011; GO:0048471; GO:0051015; GO:0051643; GO:0051646; GO:0051647; GO:0060361
GN017334	GN017334.1	Q96F81	24.3	799	1194	1524	4.70e-42	172	DISP1_HUMAN	Protein dispatched homolog 1	Homo sapiens (Human)	diaphragm development [GO:0060539]; peptide transport [GO:0015833]; regulation of protein secretion [GO:0050708]; smoothened signaling pathway [GO:0007224]	molecular carrier activity [GO:0140104]	basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]	GO:0007224; GO:0015833; GO:0016020; GO:0016323; GO:0050708; GO:0060539; GO:0140104
GN017344	GN017344.1	O77633	34.2	257	370	748	2.32e-35	140	ADA10_PIG	Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)	Sus scrofa (Pig)	adherens junction organization [GO:0034332]; cochlea development [GO:0090102]; constitutive protein ectodomain proteolysis [GO:0051089]; epidermal growth factor receptor ligand maturation [GO:0038004]; in utero embryonic development [GO:0001701]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte activation [GO:0042117]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of cell adhesion [GO:0007162]; Notch signaling pathway [GO:0007219]; pore complex assembly [GO:0046931]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; postsynapse organization [GO:0099173]; protein catabolic process at postsynapse [GO:0140249]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Notch signaling pathway [GO:0008593]; regulation of postsynapse organization [GO:0099175]; regulation of vasculature development [GO:1901342]; response to tumor necrosis factor [GO:0034612]	endopeptidase activity [GO:0004175]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; protein homodimerization activity [GO:0042803]	adherens junction [GO:0005912]; axon [GO:0030424]; cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; postsynaptic density [GO:0014069]; synaptic membrane [GO:0097060]; tetraspanin-enriched microdomain [GO:0097197]	GO:0000139; GO:0001701; GO:0004175; GO:0004222; GO:0005737; GO:0005798; GO:0005886; GO:0005912; GO:0006509; GO:0007162; GO:0007219; GO:0008284; GO:0008593; GO:0009986; GO:0010820; GO:0014069; GO:0030136; GO:0030307; GO:0030424; GO:0030425; GO:0032760; GO:0034332; GO:0034612; GO:0038004; GO:0042117; GO:0042803; GO:0042985; GO:0046930; GO:0046931; GO:0051089; GO:0070573; GO:0090102; GO:0097038; GO:0097060; GO:0097197; GO:0098696; GO:0098978; GO:0099173; GO:0099175; GO:0140249; GO:1901342; GO:1902430; GO:1902945; GO:1903265
GN017345	GN017345.1	O14672	27.1	280	295	748	1.60e-16	83.2	ADA10_HUMAN	Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)	Homo sapiens (Human)	adherens junction organization [GO:0034332]; amyloid precursor protein catabolic process [GO:0042987]; cell-cell signaling [GO:0007267]; cochlea development [GO:0090102]; constitutive protein ectodomain proteolysis [GO:0051089]; epidermal growth factor receptor ligand maturation [GO:0038004]; extracellular matrix disassembly [GO:0022617]; in utero embryonic development [GO:0001701]; integrin-mediated signaling pathway [GO:0007229]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte activation [GO:0042117]; negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of cell adhesion [GO:0007162]; negative regulation of gene expression [GO:0010629]; Notch signaling pathway [GO:0007219]; pore complex assembly [GO:0046931]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; postsynapse organization [GO:0099173]; protein catabolic process at postsynapse [GO:0140249]; protein processing [GO:0016485]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of Notch signaling pathway [GO:0008593]; regulation of postsynapse organization [GO:0099175]; regulation of vasculature development [GO:1901342]; response to tumor necrosis factor [GO:0034612]	endopeptidase activity [GO:0004175]; integrin binding [GO:0005178]; metallodipeptidase activity [GO:0070573]; metalloendopeptidase activity [GO:0004222]; metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902945]; metallopeptidase activity [GO:0008237]; protein homodimerization activity [GO:0042803]	adherens junction [GO:0005912]; axon [GO:0030424]; cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; membrane [GO:0016020]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; postsynaptic density [GO:0014069]; specific granule membrane [GO:0035579]; synaptic membrane [GO:0097060]; tertiary granule membrane [GO:0070821]; tetraspanin-enriched microdomain [GO:0097197]	GO:0000139; GO:0001701; GO:0004175; GO:0004222; GO:0005178; GO:0005737; GO:0005788; GO:0005794; GO:0005798; GO:0005886; GO:0005912; GO:0005925; GO:0006509; GO:0007162; GO:0007219; GO:0007229; GO:0007267; GO:0008237; GO:0008284; GO:0008593; GO:0009986; GO:0010629; GO:0010820; GO:0014069; GO:0016020; GO:0016485; GO:0022617; GO:0030136; GO:0030307; GO:0030335; GO:0030424; GO:0030425; GO:0032760; GO:0034332; GO:0034612; GO:0035579; GO:0038004; GO:0042117; GO:0042803; GO:0042985; GO:0042987; GO:0046930; GO:0046931; GO:0051089; GO:0070062; GO:0070573; GO:0070821; GO:0090102; GO:0097038; GO:0097060; GO:0097197; GO:0098696; GO:0098978; GO:0099173; GO:0099175; GO:0140249; GO:1901342; GO:1902430; GO:1902945; GO:1903265
GN017346	GN017346.1	Q96NR8	71.4	42	103	316	9.44e-13	65.5	RDH12_HUMAN	Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2)	Homo sapiens (Human)	cellular detoxification of aldehyde [GO:0110095]; photoreceptor cell maintenance [GO:0045494]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]	11-cis-retinol dehydrogenase (NADP+) activity [GO:0102354]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]	endoplasmic reticulum membrane [GO:0005789]; photoreceptor inner segment [GO:0001917]; photoreceptor inner segment membrane [GO:0060342]	GO:0001523; GO:0001917; GO:0004745; GO:0005789; GO:0007601; GO:0042572; GO:0045494; GO:0052650; GO:0060342; GO:0102354; GO:0110095
GN017347	GN017347.1	Q8NBN7	55.3	262	265	331	2.31e-84	258	RDH13_HUMAN	Retinol dehydrogenase 13 (EC 1.1.1.300) (Short chain dehydrogenase/reductase family 7C member 3)	Homo sapiens (Human)	eye photoreceptor cell development [GO:0042462]; retina layer formation [GO:0010842]; retinal metabolic process [GO:0042574]	all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0010842; GO:0042462; GO:0042574; GO:0052650
GN017348	GN017348.1	Q9D2G2	55.9	370	383	454	2.46e-116	348	ODO2_MOUSE	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)	Mus musculus (Mouse)	2-oxoglutarate decarboxylation to succinyl-CoA [GO:0120551]; 2-oxoglutarate metabolic process [GO:0006103]; alpha-amino acid catabolic process [GO:1901606]; amino acid catabolic process [GO:0009063]; L-lysine catabolic process [GO:0019477]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099]	acyltransferase activity [GO:0016746]; dihydrolipoyllysine-residue glutaryltransferase activity [GO:0120571]; dihydrolipoyllysine-residue succinyltransferase activity [GO:0004149]; heat shock protein binding [GO:0031072]; peptide glutaryltransferase activity [GO:0106228]; protein-folding chaperone binding [GO:0051087]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; oxoadipate dehydrogenase complex [GO:0160167]; oxoglutarate dehydrogenase complex [GO:0045252]; sarcolemma [GO:0042383]	GO:0004149; GO:0005634; GO:0005654; GO:0005739; GO:0005759; GO:0005829; GO:0006099; GO:0006103; GO:0006104; GO:0009063; GO:0016746; GO:0019477; GO:0031072; GO:0042383; GO:0043209; GO:0045252; GO:0051087; GO:0106228; GO:0120551; GO:0120571; GO:0160167; GO:1901606
GN017350	GN017350.1	Q9U6A1	76.3	152	155	1556	2.87e-76	249	PROS_DROVI	Homeobox protein prospero	Drosophila virilis (Fruit fly)	cell development [GO:0048468]; glial cell differentiation [GO:0010001]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0010001; GO:0048468
GN017353	GN017353.1	Q9H892	32.9	730	733	705	8.40e-102	331	TTC12_HUMAN	Tetratricopeptide repeat protein 12 (TPR repeat protein 12)	Homo sapiens (Human)	axonemal dynein complex assembly [GO:0070286]; sperm axoneme assembly [GO:0007288]		centrosome [GO:0005813]; cytoplasm [GO:0005737]	GO:0005737; GO:0005813; GO:0007288; GO:0070286
GN017354	GN017354.1	Q7ZVN5	87.2	436	440	504	8.94e-275	755	SRP54_DANRE	Signal recognition particle subunit SRP54 (EC 3.6.5.4) (Signal recognition particle 54 kDa protein)	Danio rerio (Zebrafish) (Brachydanio rerio)	exocrine pancreas development [GO:0031017]; granulocyte differentiation [GO:0030851]; neutrophil chemotaxis [GO:0030593]; regulation of motor neuron axon guidance [GO:1905812]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nuclear speck [GO:0016607]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]	GO:0003924; GO:0005525; GO:0005737; GO:0005783; GO:0005786; GO:0005829; GO:0006616; GO:0008312; GO:0016607; GO:0030593; GO:0030851; GO:0030942; GO:0031017; GO:1905812
GN017355	GN017355.1	Q9Y597	62.7	614	656	815	1.57e-261	743	KCTD3_HUMAN	BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45)	Homo sapiens (Human)	protein homooligomerization [GO:0051260]		plasma membrane [GO:0005886]	GO:0005886; GO:0051260
GN017356	GN017356.1	Q3B7H2	53.5	318	360	338	5.27e-110	327	TAM41_DANRE	Phosphatidate cytidylyltransferase, mitochondrial (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (Mitochondrial translocator assembly and maintenance protein 41 homolog) (TAM41)	Danio rerio (Zebrafish) (Brachydanio rerio)	cardiolipin biosynthetic process [GO:0032049]; CDP-diacylglycerol biosynthetic process [GO:0016024]	phosphatidate cytidylyltransferase activity [GO:0004605]	mitochondrial inner membrane [GO:0005743]	GO:0004605; GO:0005743; GO:0016024; GO:0032049
GN017357	GN017357.1	Q8BUZ1	48.3	120	124	375	2.96e-28	108	ABRA_MOUSE	Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein import into nucleus [GO:0006606]	actin binding [GO:0003779]	actin cytoskeleton [GO:0015629]; myofibril [GO:0030016]; plasma membrane [GO:0005886]; sarcomere [GO:0030017]	GO:0003779; GO:0005886; GO:0006606; GO:0015629; GO:0030016; GO:0030017; GO:0030036; GO:0035025; GO:0045893; GO:0045944
GN017360	GN017360.1	O08746	30.3	221	1587	956	7.46e-14	80.9	MATN2_MOUSE	Matrilin-2	Mus musculus (Mouse)	axon guidance [GO:0007411]; dendrite regeneration [GO:0031104]; extracellular matrix organization [GO:0030198]; glial cell migration [GO:0008347]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; response to axon injury [GO:0048678]	calcium ion binding [GO:0005509]	basement membrane [GO:0005604]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; matrilin complex [GO:0120216]; non-collagenous component of basement membrane [GO:0140144]	GO:0001764; GO:0005509; GO:0005576; GO:0005604; GO:0007411; GO:0008347; GO:0030198; GO:0031012; GO:0031104; GO:0031175; GO:0048678; GO:0120216; GO:0140144
GN017361	GN017361.1	Q6B9X6	30.4	148	338	625	1.87e-13	74.7	VWKA_DICDI	Alpha-protein kinase vwkA (EC 2.7.11.1) (von Willebrand factor A alpha-kinase) (vWF kinase)	Dictyostelium discoideum (Social amoeba)	contractile vacuole discharge [GO:0070177]; contractile vacuole organization [GO:0033298]; hypotonic response [GO:0006971]; mitotic cytokinesis [GO:0000281]; myosin II filament organization [GO:0031038]; regulation of sorocarp development [GO:0031156]; sorocarp morphogenesis [GO:0031288]	ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	contractile vacuolar membrane [GO:0031164]; contractile vacuole [GO:0000331]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]	GO:0000281; GO:0000331; GO:0004672; GO:0004674; GO:0005516; GO:0005524; GO:0005737; GO:0005829; GO:0006971; GO:0031038; GO:0031156; GO:0031164; GO:0031288; GO:0033298; GO:0048471; GO:0070177; GO:0106310
GN017365	GN017365.1	Q5R4N7	37.3	938	923	1251	9.39e-164	514	REV1_PONAB	Translesion synthesis protein REV1 (Molecular adapter protein REV1) (Rev1-like terminal deoxycytidyl transferase) (Reversionless protein 1 homolog) (REV1 homolog) (Template-dependent deoxycytidyl transferase REV1) (EC 2.7.7.-)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	DNA repair [GO:0006281]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; somatic hypermutation of immunoglobulin genes [GO:0016446]; translesion synthesis [GO:0019985]	damaged DNA binding [GO:0003684]; deoxycytidyl transferase activity [GO:0017125]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; ubiquitin binding [GO:0043130]	nuclear replication fork [GO:0043596]; nucleus [GO:0005634]	GO:0003677; GO:0003684; GO:0003887; GO:0005634; GO:0006281; GO:0016446; GO:0017125; GO:0019985; GO:0042276; GO:0043130; GO:0043596; GO:0070987
GN017366	GN017366.1	Q9QXD6	64.0	331	339	338	4.22e-155	441	F16P1_MOUSE	Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Fructose-1,6-bisphosphatase isozyme 3) (FBPase 3) (Liver FBPase)	Mus musculus (Mouse)	cellular hyperosmotic salinity response [GO:0071475]; cellular hypotonic salinity response [GO:0071477]; cellular response to cAMP [GO:0071320]; cellular response to insulin stimulus [GO:0032869]; cellular response to magnesium ion [GO:0071286]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to raffinose [GO:0097403]; cellular response to xenobiotic stimulus [GO:0071466]; fructose 6-phosphate metabolic process [GO:0006002]; gluconeogenesis [GO:0006094]; negative regulation of cell growth [GO:0030308]; negative regulation of glycolytic process [GO:0045820]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of gluconeogenesis [GO:0006111]; response to nutrient levels [GO:0031667]	AMP binding [GO:0016208]; fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0000122; GO:0005576; GO:0005634; GO:0005737; GO:0005829; GO:0006002; GO:0006094; GO:0006111; GO:0016208; GO:0030308; GO:0031667; GO:0032869; GO:0042132; GO:0042802; GO:0045820; GO:0046580; GO:0046872; GO:0048029; GO:0061629; GO:0071286; GO:0071320; GO:0071466; GO:0071475; GO:0071477; GO:0097403; GO:1904628
GN017367	GN017367.1	Q9NR48	47.5	1003	2361	2969	1.97e-267	871	ASH1L_HUMAN	Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H)	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone H3 methyltransferase activity [GO:0140938]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K9 methyltransferase activity [GO:0046974]; histone H3K9 monomethyltransferase activity [GO:0140948]	bicellular tight junction [GO:0005923]; chromosome [GO:0005694]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003677; GO:0003682; GO:0005634; GO:0005654; GO:0005694; GO:0005923; GO:0006355; GO:0016604; GO:0042800; GO:0046974; GO:0046975; GO:0140938; GO:0140948; GO:0140955
GN017368	GN017368.1	Q9ER88	34.2	237	249	391	2.26e-43	154	RT29_MOUSE	Small ribosomal subunit protein mS29 (EC 3.6.5.-) (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3)	Mus musculus (Mouse)	apoptotic mitochondrial changes [GO:0008637]; mitochondrial translation [GO:0032543]	GTPase activity [GO:0003924]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0003735; GO:0003924; GO:0005654; GO:0005739; GO:0005743; GO:0005759; GO:0005763; GO:0008637; GO:0032543
GN017369	GN017369.1	Q9UGJ1	52.3	642	683	667	1.58e-221	636	GCP4_HUMAN	Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (Gamma-ring complex protein 76 kDa) (h76p) (hGrip76)	Homo sapiens (Human)	meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; protein-containing complex assembly [GO:0065003]; spindle assembly [GO:0051225]	gamma-tubulin binding [GO:0043015]; structural constituent of cytoskeleton [GO:0005200]	centrosome [GO:0005813]; cytosol [GO:0005829]; gamma-tubulin complex [GO:0000930]; gamma-tubulin ring complex [GO:0000931]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; recycling endosome [GO:0055037]; spindle pole [GO:0000922]	GO:0000278; GO:0000922; GO:0000930; GO:0000931; GO:0005200; GO:0005813; GO:0005829; GO:0007020; GO:0015630; GO:0016020; GO:0043015; GO:0051225; GO:0051321; GO:0055037; GO:0065003
GN017370	GN017370.1	Q659X0	52.3	587	592	575	7.64e-216	615	FUT8_CANLF	Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase)	Canis lupus familiaris (Dog) (Canis familiaris)	GDP-L-fucose metabolic process [GO:0046368]; protein N-linked glycosylation [GO:0006487]	alpha-(1->6)-fucosyltransferase activity [GO:0046921]; glycoprotein 6-alpha-L-fucosyltransferase activity [GO:0008424]	Golgi cisterna membrane [GO:0032580]	GO:0006487; GO:0008424; GO:0032580; GO:0046368; GO:0046921
GN017371	GN017371.1	Q6TXF1	26.3	300	419	414	3.62e-25	109	ARRD3_RAT	Arrestin domain-containing protein 3 (Liver regeneration-related protein LRRG00048)	Rattus norvegicus (Rat)	fat pad development [GO:0060613]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of heat generation [GO:0031651]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; positive regulation of hippo signaling [GO:0035332]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; response to mechanical stimulus [GO:0009612]; skin development [GO:0043588]; temperature homeostasis [GO:0001659]	beta-3 adrenergic receptor binding [GO:0031699]; molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0001659; GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0009612; GO:0031651; GO:0031699; GO:0035332; GO:0043588; GO:0051443; GO:0060090; GO:0060613; GO:0071878; GO:0090327; GO:0120163
GN017372	GN017372.1	Q9BQP7	41.7	211	381	344	8.18e-49	171	MGME1_HUMAN	Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-)	Homo sapiens (Human)	mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]	5'-flap endonuclease activity [GO:0017108]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]; single-stranded DNA exodeoxyribonuclease activity [GO:0008297]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0006264; GO:0008297; GO:0017108; GO:0043504; GO:0045145
GN017373	GN017373.1	Q63ZM9	38.3	316	319	356	1.31e-40	148	ZN830_XENLA	Zinc finger protein 830 (Coiled-coil domain-containing protein 16)	Xenopus laevis (African clawed frog)	mitotic DNA damage checkpoint signaling [GO:0044773]; mitotic DNA replication checkpoint signaling [GO:0033314]; nuclear DNA replication [GO:0033260]	nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	GO:0003676; GO:0005634; GO:0005681; GO:0005694; GO:0008270; GO:0016607; GO:0033260; GO:0033314; GO:0044773
GN017376	GN017376.1	Q9W6S8	47.7	128	279	281	6.70e-27	108	SMN1_DANRE	Survival motor neuron protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	axon arborization [GO:0140060]; axon development [GO:0061564]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; dendrite development [GO:0016358]; motor neuron axon guidance [GO:0008045]; mRNA splicing, via spliceosome [GO:0000398]; neuromast regeneration [GO:0070657]; neuromuscular junction development [GO:0007528]; neuron cellular homeostasis [GO:0070050]; peripheral nervous system neuron axonogenesis [GO:0048936]; positive regulation of oxidative phosphorylation [GO:1903862]; protein complex oligomerization [GO:0051259]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of neuromuscular junction development [GO:1904396]; spliceosomal snRNP assembly [GO:0000387]; synaptic assembly at neuromuscular junction [GO:0051124]; tissue regeneration [GO:0042246]	RNA binding [GO:0003723]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; Gemini of Cajal bodies [GO:0097504]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; protein-containing complex [GO:0032991]; SMN complex [GO:0032797]; Z disc [GO:0030018]	GO:0000387; GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0007409; GO:0007528; GO:0008045; GO:0015030; GO:0016358; GO:0030018; GO:0032797; GO:0032991; GO:0036464; GO:0042246; GO:0043005; GO:0043204; GO:0048675; GO:0048841; GO:0048936; GO:0051124; GO:0051259; GO:0061564; GO:0070050; GO:0070657; GO:0097504; GO:0140060; GO:1903862; GO:1904396
GN017377	GN017377.1	Q5JTD7	44.4	151	299	316	3.96e-37	137	LRC73_HUMAN	Leucine-rich repeat-containing protein 73	Homo sapiens (Human)				
GN017378	GN017378.1	P23381	73.6	390	434	471	1.13e-216	606	SYWC_HUMAN	Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]; negative regulation of cell population proliferation [GO:0008285]; regulation of angiogenesis [GO:0045765]; translation [GO:0006412]; tryptophanyl-tRNA aminoacylation [GO:0006436]	ATP binding [GO:0005524]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; tryptophan-tRNA ligase activity [GO:0004830]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0004830; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006412; GO:0006436; GO:0008285; GO:0019901; GO:0019904; GO:0030674; GO:0032991; GO:0035556; GO:0042803; GO:0045765; GO:0070062
GN017379	GN017379.1	E9Q349	37.9	327	518	535	9.81e-70	235	WDR25_MOUSE	WD repeat-containing protein 25	Mus musculus (Mouse)				
GN017380	GN017380.1	Q8K2J9	33.8	429	441	539	8.27e-73	241	BTBD6_MOUSE	BTB/POZ domain-containing protein 6	Mus musculus (Mouse)	neurogenesis [GO:0022008]		cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0022008
GN017383	GN017383.1	Q2TBK4	30.5	233	237	278	8.70e-26	104	HAUS1_BOVIN	HAUS augmin-like complex subunit 1 (Coiled-coil domain-containing protein 5)	Bos taurus (Bovine)	centrosome cycle [GO:0007098]; spindle assembly [GO:0051225]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; HAUS complex [GO:0070652]; mitotic spindle microtubule [GO:1990498]; spindle pole [GO:0000922]	GO:0000922; GO:0005737; GO:0005813; GO:0005829; GO:0007098; GO:0051225; GO:0070652; GO:1990498
GN017384	GN017384.1	Q8JG64	56.7	432	455	505	1.06e-172	497	PDIA3_CHICK	Protein disulfide-isomerase A3 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Glucose-regulated thiol oxidoreductase 58 kDa protein)	Gallus gallus (Chicken)	peptide antigen assembly with MHC class I protein complex [GO:0002502]; protein folding [GO:0006457]	identical protein binding [GO:0042802]; lncRNA binding [GO:0106222]; protein disulfide isomerase activity [GO:0003756]; protein folding chaperone [GO:0044183]; protein-disulfide reductase activity [GO:0015035]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; melanosome [GO:0042470]; Tapasin-ERp57 complex [GO:0061779]	GO:0002502; GO:0003756; GO:0005576; GO:0005783; GO:0005788; GO:0006457; GO:0009986; GO:0015035; GO:0042470; GO:0042802; GO:0044183; GO:0061779; GO:0106222
GN017385	GN017385.1	Q9UBB5	51.2	246	248	411	4.45e-76	239	MBD2_HUMAN	Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2)	Homo sapiens (Human)	cellular response to serotonin [GO:1904015]; chromatin remodeling [GO:0006338]; DNA methylation-dependent constitutive heterochromatin formation [GO:0006346]; embryonic organ development [GO:0048568]; maternal behavior [GO:0042711]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; response to bisphenol A [GO:1903925]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; ventricular cardiac muscle tissue development [GO:0003229]	C2H2 zinc finger domain binding [GO:0070742]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; methyl-CpG binding [GO:0008327]; molecular adaptor activity [GO:0060090]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; satellite DNA binding [GO:0003696]; siRNA binding [GO:0035197]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein-containing complex [GO:0032991]	GO:0000122; GO:0000785; GO:0000792; GO:0003229; GO:0003682; GO:0003696; GO:0003729; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006338; GO:0006346; GO:0008327; GO:0009612; GO:0016581; GO:0019904; GO:0031667; GO:0032355; GO:0032991; GO:0035197; GO:0042711; GO:0042802; GO:0045892; GO:0045893; GO:0048568; GO:0060090; GO:0070742; GO:1903925; GO:1904015
GN017388	GN017388.1	Q9QY33	37.7	257	254	253	7.75e-50	167	TSN3_MOUSE	Tetraspanin-3 (Tspan-3) (OSP-associated protein 1) (OAP-1) (Tetraspanin TM4-A) (Transmembrane 4 superfamily member 8)	Mus musculus (Mouse)			plasma membrane [GO:0005886]	GO:0005886
GN017389	GN017389.1	A4UTP7	36.4	371	343	463	4.48e-34	133	MEF2C_PIG	Myocyte-specific enhancer factor 2C	Sus scrofa (Pig)	B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cardiac ventricle formation [GO:0003211]; cardiocyte differentiation [GO:0035051]; cellular response to calcium ion [GO:0071277]; cellular response to fluid shear stress [GO:0071498]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to trichostatin A [GO:0035984]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; germinal center formation [GO:0002467]; glomerulus morphogenesis [GO:0072102]; heart development [GO:0007507]; heart looping [GO:0001947]; humoral immune response [GO:0006959]; learning or memory [GO:0007611]; MAPK cascade [GO:0000165]; melanocyte differentiation [GO:0030318]; muscle cell fate determination [GO:0007521]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephron tubule epithelial cell differentiation [GO:0072160]; neural crest cell differentiation [GO:0014033]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary heart field specification [GO:0003138]; regulation of germinal center formation [GO:0002634]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of synaptic activity [GO:0060025]; renal tubule morphogenesis [GO:0061333]; secondary heart field specification [GO:0003139]; sinoatrial valve morphogenesis [GO:0003185]; skeletal muscle tissue development [GO:0007519]; smooth muscle cell differentiation [GO:0051145]; ventricular cardiac muscle cell differentiation [GO:0055012]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; sarcoplasm [GO:0016528]	GO:0000122; GO:0000165; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0001568; GO:0001649; GO:0001782; GO:0001947; GO:0001958; GO:0001974; GO:0002062; GO:0002467; GO:0002634; GO:0003138; GO:0003139; GO:0003151; GO:0003185; GO:0003211; GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0006959; GO:0007507; GO:0007519; GO:0007521; GO:0007611; GO:0010628; GO:0010629; GO:0014033; GO:0016528; GO:0016607; GO:0030182; GO:0030220; GO:0030279; GO:0030318; GO:0030501; GO:0030890; GO:0032991; GO:0035051; GO:0035984; GO:0042100; GO:0043524; GO:0045652; GO:0045663; GO:0045666; GO:0045669; GO:0045893; GO:0045944; GO:0046983; GO:0048643; GO:0048666; GO:0050853; GO:0051145; GO:0055012; GO:0060025; GO:0060045; GO:0061333; GO:0071222; GO:0071277; GO:0071374; GO:0071466; GO:0071498; GO:0071560; GO:0072102; GO:0072160; GO:2000111; GO:2000727; GO:2000987; GO:2001013; GO:2001016
GN017390	GN017390.1	Q7L5Y6	72.8	540	559	550	1.27e-286	792	DET1_HUMAN	DET1 homolog (De-etiolated-1 homolog)	Homo sapiens (Human)	positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]	protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cullin-RING ubiquitin ligase complex [GO:0031461]; nucleus [GO:0005634]	GO:0005634; GO:0016567; GO:0031461; GO:0031464; GO:0031625; GO:0032436; GO:0044877; GO:0065003; GO:0080008; GO:1990756
GN017391	GN017391.1	Q9NZ56	45.3	450	1657	1722	6.22e-97	350	FMN2_HUMAN	Formin-2	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; cell migration [GO:0016477]; cellular response to hypoxia [GO:0071456]; DNA damage response [GO:0006974]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; homologous chromosome movement towards spindle pole in meiosis I anaphase [GO:0051758]; intracellular signal transduction [GO:0035556]; intracellular transport [GO:0046907]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; oogenesis [GO:0048477]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; vesicle-mediated transport [GO:0016192]	actin binding [GO:0003779]; microtubule binding [GO:0008017]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; microtubule cytoskeleton [GO:0015630]; microvillus [GO:0005902]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle [GO:0005819]	GO:0003779; GO:0005634; GO:0005730; GO:0005783; GO:0005789; GO:0005819; GO:0005829; GO:0005886; GO:0005902; GO:0005938; GO:0006974; GO:0008017; GO:0015629; GO:0015630; GO:0016192; GO:0016477; GO:0030036; GO:0030659; GO:0035556; GO:0040038; GO:0042177; GO:0043066; GO:0046907; GO:0048471; GO:0048477; GO:0051295; GO:0051758; GO:0070649; GO:0071456; GO:2000781
GN017392	GN017392.1	A4UTP7	41.2	495	466	463	8.93e-70	232	MEF2C_PIG	Myocyte-specific enhancer factor 2C	Sus scrofa (Pig)	B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; cardiac ventricle formation [GO:0003211]; cardiocyte differentiation [GO:0035051]; cellular response to calcium ion [GO:0071277]; cellular response to fluid shear stress [GO:0071498]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to trichostatin A [GO:0035984]; cellular response to xenobiotic stimulus [GO:0071466]; chondrocyte differentiation [GO:0002062]; endochondral ossification [GO:0001958]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; germinal center formation [GO:0002467]; glomerulus morphogenesis [GO:0072102]; heart development [GO:0007507]; heart looping [GO:0001947]; humoral immune response [GO:0006959]; learning or memory [GO:0007611]; MAPK cascade [GO:0000165]; melanocyte differentiation [GO:0030318]; muscle cell fate determination [GO:0007521]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of ossification [GO:0030279]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephron tubule epithelial cell differentiation [GO:0072160]; neural crest cell differentiation [GO:0014033]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of behavioral fear response [GO:2000987]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary heart field specification [GO:0003138]; regulation of germinal center formation [GO:0002634]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of synaptic activity [GO:0060025]; renal tubule morphogenesis [GO:0061333]; secondary heart field specification [GO:0003139]; sinoatrial valve morphogenesis [GO:0003185]; skeletal muscle tissue development [GO:0007519]; smooth muscle cell differentiation [GO:0051145]; ventricular cardiac muscle cell differentiation [GO:0055012]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; sarcoplasm [GO:0016528]	GO:0000122; GO:0000165; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0001568; GO:0001649; GO:0001782; GO:0001947; GO:0001958; GO:0001974; GO:0002062; GO:0002467; GO:0002634; GO:0003138; GO:0003139; GO:0003151; GO:0003185; GO:0003211; GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0006959; GO:0007507; GO:0007519; GO:0007521; GO:0007611; GO:0010628; GO:0010629; GO:0014033; GO:0016528; GO:0016607; GO:0030182; GO:0030220; GO:0030279; GO:0030318; GO:0030501; GO:0030890; GO:0032991; GO:0035051; GO:0035984; GO:0042100; GO:0043524; GO:0045652; GO:0045663; GO:0045666; GO:0045669; GO:0045893; GO:0045944; GO:0046983; GO:0048643; GO:0048666; GO:0050853; GO:0051145; GO:0055012; GO:0060025; GO:0060045; GO:0061333; GO:0071222; GO:0071277; GO:0071374; GO:0071466; GO:0071498; GO:0071560; GO:0072102; GO:0072160; GO:2000111; GO:2000727; GO:2000987; GO:2001013; GO:2001016
GN017393	GN017393.1	P42026	81.5	162	269	216	7.58e-97	286	NDUS7_BOVIN	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 7.1.1.2) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)	Bos taurus (Bovine)	aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]	4 iron, 4 sulfur cluster binding [GO:0051539]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038]	mitochondrial inner membrane [GO:0005743]; respiratory chain complex I [GO:0045271]	GO:0005743; GO:0006120; GO:0008137; GO:0009060; GO:0015990; GO:0032981; GO:0045271; GO:0048038; GO:0051539
GN017394	GN017394.1	G1U0Q2	82.1	112	112	145	3.72e-64	194	RS15_RABIT	Small ribosomal subunit protein uS19 (40S ribosomal protein S15)	Oryctolagus cuniculus (Rabbit)	positive regulation of signal transduction by p53 class mediator [GO:1901798]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit export from nucleus [GO:0000056]; rRNA processing [GO:0006364]; translation [GO:0006412]	MDM2/MDM4 family protein binding [GO:0097371]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]	cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; cytosolic small ribosomal subunit [GO:0022627]	GO:0000028; GO:0000056; GO:0003723; GO:0003735; GO:0005737; GO:0006364; GO:0006412; GO:0022626; GO:0022627; GO:0097371; GO:1901798; GO:1990948
GN017398	GN017398.1	O94788	61.1	422	421	518	4.82e-190	540	AL1A2_HUMAN	Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (ALDH1A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II))	Homo sapiens (Human)	9-cis-retinoic acid biosynthetic process [GO:0042904]; aldehyde metabolic process [GO:0006081]; cellular response to retinoic acid [GO:0071300]; kidney development [GO:0001822]; liver development [GO:0001889]; midgut development [GO:0007494]; negative regulation of cell population proliferation [GO:0008285]; neural tube development [GO:0021915]; pituitary gland development [GO:0021983]; protein homotetramerization [GO:0051289]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinoic acid biosynthetic process [GO:0002138]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; vitamin A metabolic process [GO:0006776]	3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; retinal binding [GO:0016918]; retinal dehydrogenase (NAD+) activity [GO:0001758]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]	GO:0001758; GO:0001822; GO:0001889; GO:0002138; GO:0004028; GO:0004029; GO:0005737; GO:0005829; GO:0006081; GO:0006776; GO:0007494; GO:0008285; GO:0016918; GO:0021915; GO:0021983; GO:0032355; GO:0032526; GO:0033189; GO:0034097; GO:0042572; GO:0042573; GO:0042904; GO:0048471; GO:0051289; GO:0071300
GN017402	GN017402.1	Q16706	36.5	970	946	1144	1.52e-199	606	MA2A1_HUMAN	Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)	Homo sapiens (Human)	mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491]; viral protein processing [GO:0019082]	alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity [GO:0004572]	cis-Golgi network [GO:0005801]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0004559; GO:0004572; GO:0005794; GO:0005797; GO:0005801; GO:0006013; GO:0006491; GO:0016020; GO:0016799; GO:0019082; GO:0030246; GO:0070062
GN017404	GN017404.1	Q4V8C3	51.3	829	840	814	1.64e-299	847	EMAL1_RAT	Echinoderm microtubule-associated protein-like 1 (EMAP-1)	Rattus norvegicus (Rat)	brain development [GO:0007420]; hematopoietic progenitor cell differentiation [GO:0002244]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; neuroblast proliferation [GO:0007405]	microtubule binding [GO:0008017]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; perinuclear region of cytoplasm [GO:0048471]	GO:0000226; GO:0002244; GO:0005737; GO:0005829; GO:0005874; GO:0007052; GO:0007405; GO:0007420; GO:0008017; GO:0015630; GO:0015631; GO:0048471; GO:0097431; GO:1990023
GN017405	GN017405.1	Q0VDD8	40.9	110	753	3507	1.72e-15	85.1	DYH14_HUMAN	Dynein axonemal heavy chain 14 (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14)	Homo sapiens (Human)	cilium movement involved in cell motility [GO:0060294]	ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; dynein complex [GO:0030286]	GO:0005524; GO:0005930; GO:0008569; GO:0030286; GO:0045505; GO:0051959; GO:0060294; GO:0097729
GN017406	GN017406.1	Q9C0G6	38.1	4144	4304	4158	0.0	2716	DYH6_HUMAN	Dynein axonemal heavy chain 6 (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)	Homo sapiens (Human)	cilium movement involved in cell motility [GO:0060294]	ATP binding [GO:0005524]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; dynein complex [GO:0030286]; sperm flagellum [GO:0036126]	GO:0005524; GO:0005858; GO:0008569; GO:0030286; GO:0036126; GO:0045505; GO:0051959; GO:0060294; GO:0097729
GN017407	GN017407.1	Q6NU08	31.7	760	734	764	4.93e-101	330	MTRAB_XENLA	Myotubularin-related protein 10-B (Inactive phosphatidylinositol 3-phosphatase 10-B)	Xenopus laevis (African clawed frog)	phosphatidylinositol dephosphorylation [GO:0046856]		cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0005737; GO:0016020; GO:0046856
GN017410	GN017410.1	Q63245	54.3	94	466	101	7.42e-27	107	FOXD3_RAT	Forkhead box protein D3 (HNF3/FH transcription factor genesis) (Hepatocyte nuclear factor 3 forkhead homolog 2) (HFH-2)	Rattus norvegicus (Rat)	anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; embryonic placenta development [GO:0001892]; in utero embryonic development [GO:0001701]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; trophectodermal cell differentiation [GO:0001829]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0001701; GO:0001829; GO:0001892; GO:0003677; GO:0003690; GO:0003700; GO:0005634; GO:0006355; GO:0006357; GO:0009653; GO:0030154; GO:0045944; GO:1990830; GO:1990837
GN017412	GN017412.1	Q9JHB5	51.6	246	267	290	8.43e-73	227	TSNAX_RAT	Translin-associated protein X (Translin-associated factor X)	Rattus norvegicus (Rat)	siRNA processing [GO:0030422]	A2A adenosine receptor binding [GO:0031687]; protein-containing complex binding [GO:0044877]; RNA endonuclease activity [GO:0004521]; sequence-specific DNA binding [GO:0043565]	cytoplasm [GO:0005737]; endoribonuclease complex [GO:1902555]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0004521; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0030422; GO:0031687; GO:0043565; GO:0044877; GO:0048471; GO:1902555
GN017413	GN017413.1	B1AVY7	26.7	918	865	1312	5.15e-40	164	KI16B_MOUSE	Kinesin-like protein KIF16B	Mus musculus (Mouse)	cellular response to type II interferon [GO:0071346]; early endosome to late endosome transport [GO:0045022]; endoderm development [GO:0007492]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; formation of primary germ layer [GO:0001704]; Golgi to endosome transport [GO:0006895]; receptor catabolic process [GO:0032801]; regulation of receptor recycling [GO:0001919]; vesicle transport along microtubule [GO:0047496]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; plus-end-directed microtubule motor activity [GO:0008574]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; kinesin complex [GO:0005871]; phagocytic vesicle [GO:0045335]; spindle [GO:0005819]	GO:0001704; GO:0001919; GO:0005524; GO:0005547; GO:0005737; GO:0005768; GO:0005769; GO:0005819; GO:0005829; GO:0005871; GO:0006895; GO:0007173; GO:0007492; GO:0008017; GO:0008543; GO:0008574; GO:0031267; GO:0031901; GO:0032266; GO:0032801; GO:0035091; GO:0043325; GO:0045022; GO:0045335; GO:0047496; GO:0071346; GO:0080025
GN017414	GN017414.1	B1AVY7	70.0	393	394	1312	7.57e-170	512	KI16B_MOUSE	Kinesin-like protein KIF16B	Mus musculus (Mouse)	cellular response to type II interferon [GO:0071346]; early endosome to late endosome transport [GO:0045022]; endoderm development [GO:0007492]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; formation of primary germ layer [GO:0001704]; Golgi to endosome transport [GO:0006895]; receptor catabolic process [GO:0032801]; regulation of receptor recycling [GO:0001919]; vesicle transport along microtubule [GO:0047496]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; plus-end-directed microtubule motor activity [GO:0008574]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; kinesin complex [GO:0005871]; phagocytic vesicle [GO:0045335]; spindle [GO:0005819]	GO:0001704; GO:0001919; GO:0005524; GO:0005547; GO:0005737; GO:0005768; GO:0005769; GO:0005819; GO:0005829; GO:0005871; GO:0006895; GO:0007173; GO:0007492; GO:0008017; GO:0008543; GO:0008574; GO:0031267; GO:0031901; GO:0032266; GO:0032801; GO:0035091; GO:0043325; GO:0045022; GO:0045335; GO:0047496; GO:0071346; GO:0080025
GN017415	GN017415.1	Q5RGT6	39.1	414	537	569	9.30e-82	268	ANGE2_DANRE	RNA 2',3'-cyclic phosphatase angel2 (EC 3.-.-.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	nuclear-transcribed mRNA catabolic process, non-stop decay [GO:0070481]	magnesium ion binding [GO:0000287]; mRNA 3'-UTR binding [GO:0003730]; RNA 2',3'-cyclic phosphatase activity [GO:0160272]	mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]	GO:0000287; GO:0003730; GO:0005634; GO:0005759; GO:0070481; GO:0160272
GN017416	GN017416.1	Q86V25	57.8	258	366	355	1.79e-103	311	VASH2_HUMAN	Tubulinyl-Tyr carboxypeptidase 2 (EC 3.4.17.17) (Vasohibin-2) (Vasohibin-like protein)	Homo sapiens (Human)	axon development [GO:0061564]; cell-cell fusion [GO:0140253]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; proteolysis [GO:0006508]; regulation of angiogenesis [GO:0045765]	actin binding [GO:0003779]; metallocarboxypeptidase activity [GO:0004181]; microtubule binding [GO:0008017]; tubulin-tyrosine carboxypeptidase activity [GO:0106423]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]	GO:0001938; GO:0003779; GO:0004181; GO:0005576; GO:0005737; GO:0005829; GO:0005856; GO:0006508; GO:0008017; GO:0045765; GO:0045766; GO:0061564; GO:0106423; GO:0140253
GN017417	GN017417.1	Q8R4P9	48.0	1241	1269	1501	0.0	1080	MRP7_MOUSE	ATP-binding cassette sub-family C member 10 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 7)	Mus musculus (Mouse)	leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005524; GO:0005886; GO:0006691; GO:0008559; GO:0009925; GO:0015431; GO:0016323; GO:0016887; GO:0071716; GO:0140359
GN017419	GN017419.1	Q5F3L1	62.7	731	913	789	2.88e-315	889	KS6A5_CHICK	Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1)	Gallus gallus (Chicken)	interleukin-1-mediated signaling pathway [GO:0070498]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; regulation of DNA-templated transcription [GO:0006355]; regulation of postsynapse organization [GO:0099175]; TORC1 signaling [GO:0038202]	ATP binding [GO:0005524]; histone H2AS1 kinase activity [GO:0044024]; histone H3S10 kinase activity [GO:0035175]; histone H3S28 kinase activity [GO:0044022]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0000287; GO:0004713; GO:0005524; GO:0005654; GO:0005737; GO:0006355; GO:0035175; GO:0038202; GO:0043687; GO:0044022; GO:0044024; GO:0045892; GO:0045944; GO:0070498; GO:0099175; GO:0106310
GN017420	GN017420.1	A1A4Q2	44.7	159	169	171	7.37e-39	133	PRXD1_BOVIN	Prolyl-tRNA synthetase associated domain-containing protein 1 (PrdX deacylase domain-containing protein 1)	Bos taurus (Bovine)	aminoacyl-tRNA metabolism involved in translational fidelity [GO:0106074]	Ser-tRNA(Ala) deacylase activity [GO:0002196]		GO:0002196; GO:0106074
GN017421	GN017421.1	Q8N7H5	64.2	313	431	531	2.48e-129	386	PAF1_HUMAN	RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2)	Homo sapiens (Human)	cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; mRNA 3'-end processing [GO:0031124]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]	chromatin binding [GO:0003682]; RNA polymerase II complex binding [GO:0000993]	Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000993; GO:0001650; GO:0001711; GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0006368; GO:0016020; GO:0016593; GO:0019827; GO:0031124; GO:0034504; GO:0045638; GO:0045944; GO:0071222; GO:1902808
GN017422	GN017422.1	Q07837	32.2	609	627	685	3.20e-91	299	SLC31_HUMAN	Amino acid transporter heavy chain SLC3A1 (D2h) (Neutral and basic amino acid transport protein) (NBAT) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transporter-related heavy chain) (rBAT)	Homo sapiens (Human)	amino acid transport [GO:0006865]; aspartate transmembrane transport [GO:0015810]; basic amino acid transport [GO:0015802]; carbohydrate metabolic process [GO:0005975]; gene expression [GO:0010467]; L-cystine transport [GO:0015811]; L-glutamate transmembrane transport [GO:0015813]	amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-cystine transmembrane transporter activity [GO:0015184]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]; vacuolar membrane [GO:0005774]	GO:0005774; GO:0005886; GO:0005975; GO:0006865; GO:0010467; GO:0015171; GO:0015174; GO:0015184; GO:0015802; GO:0015810; GO:0015811; GO:0015813; GO:0016020; GO:0016324; GO:0031526; GO:0044877; GO:0046982; GO:0070062; GO:1902495
GN017424	GN017424.1	P31948	40.4	317	327	543	5.26e-59	201	STIP1_HUMAN	Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)	Homo sapiens (Human)		Hsp90 protein binding [GO:0051879]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]	GO:0003723; GO:0005634; GO:0005737; GO:0005794; GO:0005829; GO:0032991; GO:0051879; GO:0101031; GO:0120293
GN017425	GN017425.1	P31948	50.1	559	566	543	4.89e-166	486	STIP1_HUMAN	Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)	Homo sapiens (Human)		Hsp90 protein binding [GO:0051879]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]	GO:0003723; GO:0005634; GO:0005737; GO:0005794; GO:0005829; GO:0032991; GO:0051879; GO:0101031; GO:0120293
GN017427	GN017427.1	P54921	68.5	289	291	295	8.20e-142	404	SNAA_RAT	Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)	Rattus norvegicus (Rat)	apical protein localization [GO:0045176]; brain development [GO:0007420]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; neuron differentiation [GO:0030182]; positive regulation of ATP-dependent activity [GO:0032781]; protein-containing complex disassembly [GO:0032984]; regulation of synaptic vesicle priming [GO:0010807]; response to hyperoxia [GO:0055093]; SNARE complex disassembly [GO:0035494]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle priming [GO:0016082]	protein-containing complex binding [GO:0044877]; SNARE binding [GO:0000149]; soluble NSF attachment protein activity [GO:0005483]; syntaxin binding [GO:0019905]	cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; lamellar body [GO:0042599]; mitochondrion [GO:0005739]; neuromuscular junction [GO:0031594]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]; terminal bouton [GO:0043195]	GO:0000149; GO:0005483; GO:0005739; GO:0005886; GO:0006886; GO:0007420; GO:0008021; GO:0010807; GO:0016082; GO:0019905; GO:0030182; GO:0030425; GO:0031410; GO:0031594; GO:0032781; GO:0032984; GO:0035249; GO:0035494; GO:0042599; GO:0042734; GO:0043195; GO:0043204; GO:0044877; GO:0045176; GO:0045211; GO:0048787; GO:0055093; GO:0061025; GO:0070044; GO:0097060; GO:0098793; GO:0098794; GO:0098978
GN017428	GN017428.1	Q6GNT7	34.3	661	668	722	7.65e-75	258	GOGA5_XENLA	Golgin subfamily A member 5 (Golgin-84)	Xenopus laevis (African clawed frog)	Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; retrograde transport, vesicle recycling within Golgi [GO:0000301]	protein homodimerization activity [GO:0042803]; protein-macromolecule adaptor activity [GO:0030674]	Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]	GO:0000139; GO:0000301; GO:0005794; GO:0007030; GO:0030674; GO:0031985; GO:0042803; GO:0048193
GN017429	GN017429.1	O00409	56.0	218	486	490	4.00e-64	218	FOXN3_HUMAN	Forkhead box protein N3 (Checkpoint suppressor 1)	Homo sapiens (Human)	mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000981; GO:0000987; GO:0003700; GO:0005634; GO:0006355; GO:0007095; GO:0045892
GN017432	GN017432.1	B2RZ50	44.5	220	225	212	1.68e-61	194	CDKN3_RAT	Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Kinase-associated phosphatase)	Rattus norvegicus (Rat)	regulation of cell cycle [GO:0051726]	protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0004722; GO:0004725; GO:0005634; GO:0005737; GO:0005829; GO:0048471; GO:0051726
GN017435	GN017435.1	L7UZ85	76.8	884	888	885	0.0	1384	ACTN_DERFA	Alpha-actinin (F-actin cross-linking protein) (allergen Der f 24)	Dermatophagoides farinae (American house dust mite)	actin filament bundle assembly [GO:0051017]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; IgE binding [GO:0019863]		GO:0005509; GO:0019863; GO:0051015; GO:0051017
GN017437	GN017437.1	A8K0R7	29.8	326	1045	811	1.10e-23	111	ZN839_HUMAN	Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50)	Homo sapiens (Human)				
GN017438	GN017438.1	P22031	45.4	97	345	105	1.00e-18	83.6	LEG_HELCR	D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL)	Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina)		carbohydrate binding [GO:0030246]	cytoplasm [GO:0005737]	GO:0005737; GO:0030246
GN017439	GN017439.1	P22031	46.2	91	315	105	2.56e-18	82.0	LEG_HELCR	D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL)	Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina)		carbohydrate binding [GO:0030246]	cytoplasm [GO:0005737]	GO:0005737; GO:0030246
GN017445	GN017445.1	Q01177	39.1	230	1022	812	6.33e-42	169	PLMN_RAT	Plasminogen [Cleaved into: Plasmin (EC 3.4.21.7); Plasmin heavy chain A; Plasmin light chain B; Angiostatin]	Rattus norvegicus (Rat)	blood coagulation [GO:0007596]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; fibrinolysis [GO:0042730]; labyrinthine layer blood vessel development [GO:0060716]; mononuclear cell migration [GO:0071674]; muscle cell cellular homeostasis [GO:0046716]; myoblast differentiation [GO:0045445]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of fibrinolysis [GO:0051919]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; tissue regeneration [GO:0042246]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]; trophoblast giant cell differentiation [GO:0060707]	apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein antigen binding [GO:1990405]; protein domain specific binding [GO:0019904]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0002020; GO:0004175; GO:0004252; GO:0005102; GO:0005576; GO:0006508; GO:0007596; GO:0009897; GO:0009986; GO:0010812; GO:0016485; GO:0019899; GO:0019900; GO:0019904; GO:0022617; GO:0030163; GO:0030574; GO:0034185; GO:0042246; GO:0042730; GO:0043536; GO:0045445; GO:0046716; GO:0051087; GO:0051918; GO:0051919; GO:0060707; GO:0060716; GO:0071674; GO:0098685; GO:0098978; GO:0099183; GO:1990405
GN017447	GN017447.1	Q5R4M2	45.7	1281	1285	1275	0.0	1046	ULK4_PONAB	Inactive serine/threonine-protein kinase ULK4 (Pseudokinase ULK4) (Unc-51-like kinase 4)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	microtubule cytoskeleton organization [GO:0000226]; positive regulation of smoothened signaling pathway [GO:0045880]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein-macromolecule adaptor activity [GO:0030674]	ciliary tip [GO:0097542]	GO:0000226; GO:0004672; GO:0005524; GO:0030674; GO:0045880; GO:0097542
GN017448	GN017448.1	P47990	60.0	1261	1289	1358	0.0	1526	XDH_CHICK	Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)]	Gallus gallus (Chicken)	urate biosynthetic process [GO:0034418]; xanthine catabolic process [GO:0009115]	2 iron, 2 sulfur cluster binding [GO:0051537]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; hypoxanthine dehydrogenase activity [GO:0070674]; iron ion binding [GO:0005506]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; xanthine dehydrogenase activity [GO:0004854]; xanthine oxidase activity [GO:0004855]	cytosol [GO:0005829]; peroxisome [GO:0005777]	GO:0004854; GO:0004855; GO:0005506; GO:0005777; GO:0005829; GO:0009115; GO:0030151; GO:0034418; GO:0043546; GO:0050660; GO:0051537; GO:0070674; GO:0071949
GN017450	GN017450.1	Q9P6P2	50.0	66	86	279	1.82e-09	55.5	RRP36_SCHPO	rRNA biogenesis protein rrp36 (Ribosomal RNA-processing protein 36)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]		90S preribosome [GO:0030686]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0000462; GO:0005634; GO:0005730; GO:0030686
GN017451	GN017451.1	Q96MX6	76.0	354	355	357	5.22e-209	579	DAA10_HUMAN	Dynein axonemal assembly factor 10 (WD repeat-containing protein 92) (WD repeat-containing protein Monad)	Homo sapiens (Human)	axonemal dynein complex assembly [GO:0070286]; protein stabilization [GO:0050821]	ubiquitin binding [GO:0043130]	dynein axonemal particle [GO:0120293]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]	GO:0043130; GO:0050821; GO:0070286; GO:0120293; GO:1990062
GN017452	GN017452.1	Q568G4	44.7	150	173	167	7.54e-39	133	EFC11_DANRE	EF-hand calcium-binding domain-containing protein 11	Danio rerio (Zebrafish) (Brachydanio rerio)	microtubule cytoskeleton organization [GO:0000226]	calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]		GO:0000226; GO:0005509; GO:0030234
GN017453	GN017453.1	Q7TSL3	78.5	776	833	843	3.83e-121	389	FBX11_RAT	F-box only protein 11	Rattus norvegicus (Rat)	negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; sensory perception of sound [GO:0007605]; ubiquitin-dependent protein catabolic process [GO:0006511]	protein-arginine N-methyltransferase activity [GO:0016274]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004842; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006511; GO:0007605; GO:0008270; GO:0010719; GO:0016274; GO:0016567; GO:0042981; GO:0043161; GO:0045732; GO:1904878; GO:1990756
GN017454	GN017454.1	Q7JK24	33.3	144	222	326	4.72e-19	87.0	B3GT1_GORGO	Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.86) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)	Gorilla gorilla gorilla (Western lowland gorilla)	glucosylceramide metabolic process [GO:0006678]; glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006678; GO:0008499; GO:0009101; GO:0009312
GN017461	GN017461.1	Q90481	46.9	254	357	269	2.73e-51	174	NX22A_DANRE	Homeobox protein Nkx-2.2a (Homeobox protein NK-2 homolog B-A)	Danio rerio (Zebrafish) (Brachydanio rerio)	cell differentiation [GO:0030154]; endocrine pancreas development [GO:0031018]; floor plate development [GO:0033504]; floor plate formation [GO:0021508]; glial cell migration [GO:0008347]; motor neuron axon guidance [GO:0008045]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; Schwann cell development [GO:0014044]; spinal cord oligodendrocyte cell differentiation [GO:0021529]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; ventral spinal cord interneuron differentiation [GO:0021514]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0008045; GO:0008347; GO:0014044; GO:0021508; GO:0021514; GO:0021529; GO:0021530; GO:0030154; GO:0031018; GO:0033504; GO:0045893
GN017462	GN017462.1	O54692	35.5	784	790	779	8.58e-145	447	ZW10_MOUSE	Centromere/kinetochore protein zw10 homolog	Mus musculus (Mouse)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to kinetochore [GO:0034501]; protein-containing complex assembly [GO:0065003]; regulation of exit from mitosis [GO:0007096]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; RZZ complex [GO:1990423]; spindle pole [GO:0000922]	GO:0000070; GO:0000132; GO:0000776; GO:0000922; GO:0005634; GO:0005737; GO:0005783; GO:0005789; GO:0005811; GO:0005828; GO:0005829; GO:0006888; GO:0007030; GO:0007080; GO:0007094; GO:0007096; GO:0034501; GO:0065003; GO:0070939; GO:1990423
GN017470	GN017470.1	A7MBH3	36.2	94	243	327	3.20e-09	59.7	NAIF1_BOVIN	Nuclear apoptosis-inducing factor 1	Bos taurus (Bovine)	negative regulation of cell growth [GO:0030308]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]		nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0030308; GO:1902108
GN017473	GN017473.1	Q8ND07	44.2	459	530	529	2.41e-103	323	BBOF1_HUMAN	Basal body-orientation factor 1 (Coiled-coil domain-containing protein 176)	Homo sapiens (Human)	flagellated sperm motility [GO:0030317]; motile cilium assembly [GO:0044458]; sperm axoneme assembly [GO:0007288]		axoneme [GO:0005930]; ciliary basal body [GO:0036064]; sperm flagellum [GO:0036126]	GO:0005930; GO:0007288; GO:0030317; GO:0036064; GO:0036126; GO:0044458
GN017475	GN017475.1	Q498J9	40.3	201	466	233	1.59e-41	150	MBLC1_XENLA	Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1)	Xenopus laevis (African clawed frog)	histone mRNA metabolic process [GO:0008334]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0008334; GO:0046872; GO:1900087
GN017479	GN017479.1	Q9WVL0	60.0	100	165	216	8.16e-33	119	MAAI_MOUSE	Maleylacetoacetate isomerase (MAAI) (EC 5.2.1.2) (GSTZ1-1) (Glutathione S-transferase zeta 1) (EC 2.5.1.18)	Mus musculus (Mouse)	cellular detoxification [GO:1990748]; glutathione metabolic process [GO:0006749]; L-phenylalanine catabolic process [GO:0006559]; L-tyrosine catabolic process [GO:0006572]	glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; maleylacetoacetate isomerase activity [GO:0016034]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004364; GO:0005739; GO:0005759; GO:0005829; GO:0006559; GO:0006572; GO:0006749; GO:0016034; GO:0042802; GO:0042803; GO:1990748
GN017480	GN017480.1	Q29IL2	65.2	92	148	749	6.16e-39	142	POMT2_DROPS	Protein O-mannosyl-transferase 2 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 2) (Protein twisted)	Drosophila pseudoobscura pseudoobscura (Fruit fly)	muscle organ development [GO:0007517]	dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0004169; GO:0005783; GO:0005789; GO:0007517
GN017481	GN017481.1	A8Y1P7	37.4	265	371	384	1.67e-53	184	BRE4_CAEBR	Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.244) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)	Caenorhabditis briggsae	carbohydrate metabolic process [GO:0005975]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; positive regulation of Notch signaling pathway [GO:0045747]; response to toxic substance [GO:0009636]	N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity [GO:0033842]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0005794; GO:0005975; GO:0006688; GO:0009101; GO:0009636; GO:0016020; GO:0033842; GO:0045747
GN017482	GN017482.1	Q6IUR5	50.9	106	162	171	7.80e-34	120	NENF_RAT	Neudesin (Neuron-derived neurotrophic factor) (SCIRP10-related protein) (Spinal cord injury-related protein 10)	Rattus norvegicus (Rat)	negative regulation of appetite [GO:0032099]; positive regulation of MAPK cascade [GO:0043410]	growth factor activity [GO:0008083]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]	GO:0005576; GO:0005739; GO:0005783; GO:0008083; GO:0032099; GO:0043410
GN017485	GN017485.1	Q9VXK6	51.9	468	451	464	6.48e-140	412	IF5_DROME	Eukaryotic translation initiation factor 5 (eIF-5)	Drosophila melanogaster (Fruit fly)	formation of cytoplasmic translation initiation complex [GO:0001732]; translational initiation [GO:0006413]	eukaryotic initiation factor eIF2 binding [GO:0071074]; GDP-dissociation inhibitor activity [GO:0005092]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]	GO:0001732; GO:0003743; GO:0005092; GO:0005829; GO:0006413; GO:0071074
GN017486	GN017486.1	P46825	79.0	577	699	571	4.41e-171	504	KLC_DORPE	Kinesin light chain (KLC)	Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)	microtubule-based movement [GO:0007018]	kinesin binding [GO:0019894]	cytoplasm [GO:0005737]; kinesin complex [GO:0005871]	GO:0005737; GO:0005871; GO:0007018; GO:0019894
GN017487	GN017487.1	Q00963	58.1	2459	2457	2291	0.0	2616	SPTCB_DROME	Spectrin beta chain	Drosophila melanogaster (Fruit fly)	actin cytoskeleton organization [GO:0030036]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; axonogenesis [GO:0007409]; long-term strengthening of neuromuscular junction [GO:0042062]; maintenance of presynaptic active zone structure [GO:0048790]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; neuron development [GO:0048666]; photoreceptor cell axon guidance [GO:0072499]; regulation of plasma membrane organization [GO:1903729]; regulation of synapse organization [GO:0050807]	actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; microtubule binding [GO:0008017]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; structural constituent of cytoskeleton [GO:0005200]	axon [GO:0030424]; cell junction [GO:0030054]; cortical actin cytoskeleton [GO:0030864]; fusome [GO:0045169]; lateral plasma membrane [GO:0016328]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; spectrin [GO:0008091]; spectrosome [GO:0045170]	GO:0005200; GO:0005546; GO:0005886; GO:0007026; GO:0007274; GO:0007399; GO:0007409; GO:0007411; GO:0008017; GO:0008091; GO:0016199; GO:0016328; GO:0030036; GO:0030054; GO:0030424; GO:0030506; GO:0030864; GO:0031594; GO:0042062; GO:0045169; GO:0045170; GO:0048666; GO:0048790; GO:0050807; GO:0051015; GO:0072499; GO:1903729
GN017488	GN017488.1	Q80T85	61.0	364	666	946	2.13e-127	402	DCAF5_MOUSE	DDB1- and CUL4-associated factor 5 (WD repeat-containing protein 22)	Mus musculus (Mouse)	protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; protein-containing complex assembly [GO:0065003]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; mitochondrion [GO:0005739]	GO:0005739; GO:0016567; GO:0030163; GO:0065003; GO:0080008
GN017490	GN017490.1	Q99N01	33.9	221	224	723	1.35e-43	158	SO4A1_RAT	Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12)	Rattus norvegicus (Rat)	sodium-independent organic anion transport [GO:0043252]; thyroid hormone metabolic process [GO:0042403]	prostaglandin transmembrane transporter activity [GO:0015132]; thyroid hormone transmembrane transporter activity [GO:0015349]; transmembrane transporter activity [GO:0022857]	basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; plasma membrane [GO:0005886]	GO:0005886; GO:0015132; GO:0015349; GO:0016323; GO:0022857; GO:0030054; GO:0042403; GO:0043252
GN017494	GN017494.1	Q9Y6R9	52.5	305	561	512	8.16e-77	254	CCD61_HUMAN	Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog)	Homo sapiens (Human)	centriole assembly [GO:0098534]; mitotic spindle assembly [GO:0090307]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	centriolar satellite [GO:0034451]; centriolar subdistal appendage [GO:0120103]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; microtubule organizing center [GO:0005815]	GO:0005813; GO:0005815; GO:0008017; GO:0034451; GO:0036064; GO:0042802; GO:0090307; GO:0098534; GO:0120103
GN017495	GN017495.1	Q58D00	27.3	209	501	454	4.76e-14	77.8	FBXW2_BOVIN	F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2)	Bos taurus (Bovine)				
GN017497	GN017497.1	Q4R642	52.4	292	521	501	3.43e-99	311	DRC5_MACFA	Dynein regulatory complex subunit 5 (T-complex-associated testis-expressed protein 1) (Tcte-1)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	flagellated sperm motility [GO:0030317]		sperm flagellum [GO:0036126]	GO:0030317; GO:0036126
GN017498	GN017498.1	Q2T9V8	64.8	105	141	209	3.12e-46	152	DTD1_BOVIN	D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase)	Bos taurus (Bovine)	tRNA metabolic process [GO:0006399]	D-aminoacyl-tRNA deacylase activity [GO:0051499]; D-tyrosyl-tRNA(Tyr) deacylase activity [GO:0051500]; Gly-tRNA(Ala) deacylase activity [GO:0106026]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0006399; GO:0051499; GO:0051500; GO:0106026
GN017501	GN017501.1	Q6A070	46.1	521	1085	1776	4.92e-125	424	TGRM1_MOUSE	TOG array regulator of axonemal microtubules protein 1 (Crescerin-1) (Protein FAM179B)	Mus musculus (Mouse)	axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; non-motile cilium assembly [GO:1905515]; positive regulation of microtubule polymerization [GO:0031116]	identical protein binding [GO:0042802]; microtubule binding [GO:0008017]	axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasmic microtubule [GO:0005881]	GO:0000226; GO:0005881; GO:0005929; GO:0005930; GO:0008017; GO:0031116; GO:0035082; GO:0036064; GO:0042802; GO:0060271; GO:1905515
GN017502	GN017502.1	A0JN53	32.3	1419	1369	1395	6.30e-204	638	RPAP1_BOVIN	RNA polymerase II-associated protein 1	Bos taurus (Bovine)	transcription by RNA polymerase II [GO:0006366]		nucleus [GO:0005634]	GO:0005634; GO:0006366
GN017503	GN017503.1	A1A5F2	55.4	2060	2054	2052	0.0	2160	HTR5B_XENTR	HEAT repeat-containing protein 5B	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	axis elongation [GO:0003401]; endocytosis [GO:0006897]; intracellular protein localization [GO:0008104]; retrograde transport, endosome to Golgi [GO:0042147]		clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; Golgi apparatus [GO:0005794]	GO:0003401; GO:0005794; GO:0005829; GO:0006897; GO:0008104; GO:0030136; GO:0030139; GO:0042147
GN017505	GN017505.1	Q80XC2	58.0	255	349	290	5.70e-100	300	TRM61_MOUSE	tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A)	Mus musculus (Mouse)	mRNA processing [GO:0006397]; tRNA methylation [GO:0030488]	mRNA (adenine-N1-)-methyltransferase activity [GO:0061953]; tRNA (adenine(58)-N1)-methyltransferase activity [GO:0160107]	nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515]	GO:0005634; GO:0006397; GO:0030488; GO:0031515; GO:0061953; GO:0160107
GN017507	GN017507.1	Q5EGE1	47.3	237	477	461	3.17e-69	231	ISM1_DANRE	Isthmin-1	Danio rerio (Zebrafish) (Brachydanio rerio)	angiogenesis [GO:0001525]; antiviral innate immune response [GO:0140374]; embryonic hemopoiesis [GO:0035162]; erythrocyte differentiation [GO:0030218]; hematopoietic stem cell proliferation [GO:0071425]; negative regulation of angiogenesis [GO:0016525]		extracellular region [GO:0005576]	GO:0001525; GO:0005576; GO:0016525; GO:0030218; GO:0035162; GO:0071425; GO:0140374
GN017513	GN017513.1	O15040	28.9	1453	1509	1411	7.18e-146	486	TCPR2_HUMAN	Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297)	Homo sapiens (Human)	protein exit from endoplasmic reticulum [GO:0032527]		cytoplasm [GO:0005737]	GO:0005737; GO:0032527
GN017514	GN017514.1	Q8TDP1	28.1	153	144	164	8.83e-12	62.4	RNH2C_HUMAN	Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C)	Homo sapiens (Human)	mismatch repair [GO:0006298]; RNA catabolic process [GO:0006401]		nucleus [GO:0005634]; ribonuclease H2 complex [GO:0032299]	GO:0005634; GO:0006298; GO:0006401; GO:0032299
GN017520	GN017520.1	B5DG42	88.9	404	1343	406	1.30e-247	716	IF4A3_SALSA	Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic translation initiation factor 4A isoform 3)	Salmo salar (Atlantic salmon)	mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0000381; GO:0000398; GO:0003676; GO:0003724; GO:0005524; GO:0005634; GO:0005737; GO:0016607; GO:0016887; GO:0071006
GN017523	GN017523.1	A6H8J1	55.1	227	376	442	9.99e-85	267	PRRCA_XENLA	Protein PRRC1-A (Proline-rich and coiled-coil-containing protein 1-A)	Xenopus laevis (African clawed frog)	epithelial structure maintenance [GO:0010669]	protein kinase A regulatory subunit binding [GO:0034237]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]	GO:0005737; GO:0005794; GO:0010669; GO:0034237
GN017524	GN017524.1	P08953	25.4	460	622	1097	3.23e-21	102	TOLL_DROME	Protein toll	Drosophila melanogaster (Fruit fly)	antifungal innate immune response [GO:0061760]; cell competition in a multicellular organism [GO:0035212]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; detection of virus [GO:0009597]; dorsal/ventral axis specification [GO:0009950]; heart development [GO:0007507]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; negative regulation of cell growth [GO:0030308]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of antifungal peptide production [GO:0002804]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; response to tumor cell [GO:0002347]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]	cytokine binding [GO:0019955]; cytokine receptor activity [GO:0004896]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; TIR domain binding [GO:0070976]; transmembrane signaling receptor activity [GO:0004888]; virion binding [GO:0046790]	cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0002225; GO:0002229; GO:0002347; GO:0002804; GO:0004888; GO:0004896; GO:0005737; GO:0005769; GO:0005886; GO:0007165; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009597; GO:0009611; GO:0009897; GO:0009950; GO:0009986; GO:0016201; GO:0019955; GO:0030308; GO:0032154; GO:0035208; GO:0035212; GO:0038023; GO:0040015; GO:0042802; GO:0045087; GO:0045944; GO:0046627; GO:0046790; GO:0050830; GO:0061760; GO:0070976; GO:1902875
GN017526	GN017526.1	P86789	51.9	77	92	302	2.30e-20	85.5	GIGA6_MAGGI	Gigasin-6	Magallana gigas (Pacific oyster) (Crassostrea gigas)			membrane [GO:0016020]	GO:0016020
GN017527	GN017527.1	P86789	43.2	257	893	302	1.16e-62	217	GIGA6_MAGGI	Gigasin-6	Magallana gigas (Pacific oyster) (Crassostrea gigas)			membrane [GO:0016020]	GO:0016020
GN017529	GN017529.1	P86789	49.5	109	388	302	9.12e-29	117	GIGA6_MAGGI	Gigasin-6	Magallana gigas (Pacific oyster) (Crassostrea gigas)			membrane [GO:0016020]	GO:0016020
GN017531	GN017531.1	P86789	49.5	109	388	302	9.12e-29	117	GIGA6_MAGGI	Gigasin-6	Magallana gigas (Pacific oyster) (Crassostrea gigas)			membrane [GO:0016020]	GO:0016020
GN017536	GN017536.1	P86789	67.0	279	566	302	7.04e-135	397	GIGA6_MAGGI	Gigasin-6	Magallana gigas (Pacific oyster) (Crassostrea gigas)			membrane [GO:0016020]	GO:0016020
GN017537	GN017537.1	P86789	26.6	233	479	302	8.77e-17	84.3	GIGA6_MAGGI	Gigasin-6	Magallana gigas (Pacific oyster) (Crassostrea gigas)			membrane [GO:0016020]	GO:0016020
GN017538	GN017538.1	P86789	70.6	279	553	302	1.54e-138	406	GIGA6_MAGGI	Gigasin-6	Magallana gigas (Pacific oyster) (Crassostrea gigas)			membrane [GO:0016020]	GO:0016020
GN017540	GN017540.1	P86789	49.2	252	526	302	3.83e-77	248	GIGA6_MAGGI	Gigasin-6	Magallana gigas (Pacific oyster) (Crassostrea gigas)			membrane [GO:0016020]	GO:0016020
GN017544	GN017544.1	Q14181	44.9	573	1444	598	4.81e-145	459	DPOA2_HUMAN	DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit)	Homo sapiens (Human)	DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of primer [GO:0006269]	DNA binding [GO:0003677]	alpha DNA polymerase:primase complex [GO:0005658]; nucleoplasm [GO:0005654]	GO:0003677; GO:0005654; GO:0005658; GO:0006260; GO:0006269; GO:0006270
GN017578	GN017578.1	Q00719	35.0	180	273	221	2.31e-26	105	MDMC_STRMY	O-methyltransferase MdmC (EC 2.1.1.-)	Streptomyces mycarofaciens		O-methyltransferase activity [GO:0008171]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]		GO:0008171; GO:0008757
GN017580	GN017580.1	P15043	35.7	84	110	609	3.89e-09	55.8	RECQ_ECOLI	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Escherichia coli (strain K12)	DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; G-quadruplex unwinding activity [GO:0160225]; single-stranded DNA helicase activity [GO:0017116]; transition metal ion binding [GO:0046914]; zinc ion binding [GO:0008270]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]; single-stranded DNA-dependent ATP-dependent DNA helicase complex [GO:0017117]	GO:0003677; GO:0003678; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0006974; GO:0008094; GO:0008270; GO:0009432; GO:0016887; GO:0017116; GO:0017117; GO:0030894; GO:0043138; GO:0043590; GO:0046914; GO:0160225
GN017583	GN017583.1	H2A0N5	40.8	157	148	157	1.19e-31	113	KCP3_PINMG	BPTI/Kunitz domain-containing protein 3 (Nacre serine protease inhibitor 2)	Margaritifera margaritifera (Freshwater pearl mussel)		serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]	GO:0004867; GO:0005576
GN017585	GN017585.1	P86963	68.4	79	343	337	2.82e-28	115	KCP2_PINMA	BPTI/Kunitz domain-containing protein 2 (Nacre serine protease inhibitor 1) (NSPI1)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]	GO:0004867; GO:0005576
GN017586	GN017586.1	P86733	46.3	108	499	126	4.94e-34	127	KCP_HALAI	BPTI/Kunitz domain-containing protein	Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone)		serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]	GO:0004867; GO:0005576
GN017599	GN017599.1	P53405	63.8	340	403	349	9.23e-152	436	ISL1_DANRE	Insulin gene enhancer protein isl-1 (Islet-1)	Danio rerio (Zebrafish) (Brachydanio rerio)	atrial cardiac muscle cell differentiation [GO:0055011]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; endocrine pancreas development [GO:0031018]; exocrine pancreas development [GO:0031017]; GABAergic neuron differentiation [GO:0097154]; heart development [GO:0007507]; neuron development [GO:0048666]; neuron fate specification [GO:0048665]; pancreatic A cell development [GO:0003322]; pancreatic D cell development [GO:0003324]; peripheral nervous system neuron axonogenesis [GO:0048936]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of heart contraction [GO:0008016]; sinoatrial node cell development [GO:0060931]; spinal cord association neuron differentiation [GO:0021527]; spinal cord motor neuron differentiation [GO:0021522]; type B pancreatic cell development [GO:0003323]	cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]	nucleus [GO:0005634]	GO:0000981; GO:0000987; GO:0003322; GO:0003323; GO:0003324; GO:0005634; GO:0007409; GO:0007507; GO:0008016; GO:0021522; GO:0021527; GO:0031017; GO:0031018; GO:0045944; GO:0048665; GO:0048666; GO:0048675; GO:0048936; GO:0055011; GO:0060931; GO:0097154
GN017600	GN017600.1	Q95WY0	86.4	191	407	233	3.52e-34	130	TPM03_MAGGI	Tropomyosin (Allergen Cra g 1.03) (allergen Cra g 1)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	regulation of muscle contraction [GO:0006937]	protein homodimerization activity [GO:0042803]		GO:0006937; GO:0042803
GN017602	GN017602.1	Q4V9P6	51.9	339	353	348	2.51e-121	356	ADAL_DANRE	N6-Methyl-AMP deaminase (EC 3.5.4.-) (Adenosine deaminase-like protein) (N6,N6-dimethyl-AMP deaminase) (EC 3.5.4.-) (N6-isopentenyl-AMP deaminase) (EC 3.5.4.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	adenosine catabolic process [GO:0006154]; camera-type eye development [GO:0043010]; inosine biosynthetic process [GO:0046103]; toxic metabolite repair [GO:0110052]	adenosine deaminase activity [GO:0004000]; N6-methyl-AMP deaminase activity [GO:0062154]		GO:0004000; GO:0006154; GO:0043010; GO:0046103; GO:0062154; GO:0110052
GN017604	GN017604.1	V5NAL9	30.9	405	398	899	3.66e-33	135	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN017605	GN017605.1	P49582	45.3	519	483	502	5.27e-149	437	ACHA7_MOUSE	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Mus musculus (Mouse)	acetylcholine receptor signaling pathway [GO:0095500]; activation of protein kinase C activity [GO:1990051]; associative learning [GO:0008306]; B cell activation [GO:0042113]; behavioral response to ethanol [GO:0048149]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; dendrite arborization [GO:0140059]; dendritic spine organization [GO:0097061]; endocytosis [GO:0006897]; flagellated sperm motility [GO:0030317]; generation of ovulation cycle rhythm [GO:0060112]; intracellular calcium ion homeostasis [GO:0006874]; learning or memory [GO:0007611]; ligand-gated ion channel signaling pathway [GO:1990806]; membrane depolarization [GO:0051899]; memory [GO:0007613]; modulation of chemical synaptic transmission [GO:0050804]; modulation of excitatory postsynaptic potential [GO:0098815]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; neuronal action potential [GO:0019228]; ovulation cycle [GO:0042698]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure [GO:0001988]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein metabolic process [GO:0051247]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of amyloid fibril formation [GO:1905906]; regulation of inflammatory response [GO:0050727]; regulation of membrane potential [GO:0042391]; regulation of norepinephrine secretion [GO:0014061]; regulation of response to drug [GO:2001023]; regulation of synapse structural plasticity [GO:0051823]; regulation of synaptic transmission, dopaminergic [GO:0032225]; response to acetylcholine [GO:1905144]; response to amyloid-beta [GO:1904645]; response to cold [GO:0009409]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; sensory processing [GO:0050893]; synapse organization [GO:0050808]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]; T cell activation [GO:0042110]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; adenylate cyclase binding [GO:0008179]; amyloid-beta binding [GO:0001540]; ATPase binding [GO:0051117]; chloride channel regulator activity [GO:0017081]; monoatomic ion channel activity [GO:0005216]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; toxic substance binding [GO:0015643]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	acetylcholine-gated channel complex [GO:0005892]; apical plasma membrane [GO:0016324]; asymmetric synapse [GO:0032279]; axolemma [GO:0030673]; axon [GO:0030424]; cation channel complex [GO:0034703]; cell surface [GO:0009986]; cholinergic synapse [GO:0098981]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; external side of plasma membrane [GO:0009897]; glycinergic synapse [GO:0098690]; growth cone [GO:0030426]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; neurotransmitter receptor complex [GO:0098878]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; spine apparatus membrane [GO:0098897]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0001988; GO:0004888; GO:0005216; GO:0005886; GO:0005892; GO:0006811; GO:0006812; GO:0006816; GO:0006874; GO:0006897; GO:0007271; GO:0007611; GO:0007613; GO:0008179; GO:0008284; GO:0008306; GO:0009409; GO:0009897; GO:0009986; GO:0010628; GO:0014061; GO:0015464; GO:0015643; GO:0016020; GO:0016324; GO:0017081; GO:0019228; GO:0019901; GO:0022848; GO:0030317; GO:0030424; GO:0030425; GO:0030426; GO:0030594; GO:0030673; GO:0032094; GO:0032225; GO:0032279; GO:0032691; GO:0032715; GO:0032720; GO:0034220; GO:0034703; GO:0035094; GO:0035095; GO:0042110; GO:0042113; GO:0042166; GO:0042391; GO:0042698; GO:0042734; GO:0042803; GO:0043005; GO:0043025; GO:0043124; GO:0043197; GO:0043198; GO:0044853; GO:0045202; GO:0045211; GO:0045471; GO:0045766; GO:0048149; GO:0050727; GO:0050728; GO:0050804; GO:0050808; GO:0050893; GO:0051117; GO:0051247; GO:0051823; GO:0051899; GO:0060084; GO:0060112; GO:0070373; GO:0070374; GO:0095500; GO:0097061; GO:0097110; GO:0098690; GO:0098793; GO:0098815; GO:0098878; GO:0098897; GO:0098981; GO:0099171; GO:0099634; GO:0140059; GO:1900016; GO:1900273; GO:1902004; GO:1902430; GO:1904315; GO:1904645; GO:1905144; GO:1905906; GO:1990051; GO:1990806; GO:2000463; GO:2001023
GN017607	GN017607.1	Q2NKJ3	22.9	656	663	1217	4.52e-22	105	CTC1_HUMAN	CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B)	Homo sapiens (Human)	negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of DNA replication [GO:0045740]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]	G-rich strand telomeric DNA binding [GO:0098505]; single-stranded DNA binding [GO:0003697]; telomeric repeat DNA binding [GO:0042162]	chromosome, telomeric region [GO:0000781]; CST complex [GO:1990879]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000723; GO:0000781; GO:0003697; GO:0005634; GO:0005654; GO:0010833; GO:0016233; GO:0032211; GO:0042162; GO:0045740; GO:0098505; GO:1990879
GN017608	GN017608.1	P09478	43.1	538	503	567	1.30e-141	422	ACH1_DROME	Acetylcholine receptor subunit alpha-like 1 (Nicotinic acetylcholine receptor alpha 1)	Drosophila melanogaster (Fruit fly)	calcium ion transport [GO:0006816]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; response to insecticide [GO:0017085]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0017085; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211; GO:0098655
GN017609	GN017609.1	P91766	66.3	371	455	516	3.08e-167	483	ACH1_MANSE	Acetylcholine receptor subunit alpha-like (MARA1)	Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)	synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; transmembrane signaling receptor activity [GO:0004888]	postsynaptic membrane [GO:0045211]	GO:0004888; GO:0007271; GO:0022848; GO:0045211
GN017610	GN017610.1	P04755	51.1	509	551	521	1.68e-154	455	ACH3_DROME	Acetylcholine receptor subunit beta-like 1 (Nicotinic acetylcholine receptor beta 1)	Drosophila melanogaster (Fruit fly)	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211
GN017612	GN017612.1	V5NAL9	21.8	864	541	899	5.78e-41	161	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN017616	GN017616.1	Q498J9	41.8	201	466	233	1.34e-45	161	MBLC1_XENLA	Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1)	Xenopus laevis (African clawed frog)	histone mRNA metabolic process [GO:0008334]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0008334; GO:0046872; GO:1900087
GN017626	GN017626.1	C4JF79	32.3	412	394	619	2.03e-59	206	UNCH_UNCRE	Peptidase uncH (EC 3.4.14.-) (Isoindolinone tripeptide biosynthesis cluster protein H)	Uncinocarpus reesii (strain UAMH 1704) (Gymnoascus siglerae)	proteolysis [GO:0006508]	serine-type peptidase activity [GO:0008236]		GO:0006508; GO:0008236
GN017628	GN017628.1	Q24157	35.4	175	168	325	3.63e-26	104	BRN_DROME	Beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase brn (EC 2.4.1.-) (Glycolipid-specific beta-1,3-N-Acetylglucosaminyltransferase brn) (Neurogenic secreted-signaling protein brn) (Protein brainiac) (UDP-GlcNAc:beta-Man/beta-Gal beta-1,3GlcNAc transferase) (beta3GlcNAc-transferase)	Drosophila melanogaster (Fruit fly)	arthro-series glucosylceramide biosynthetic process [GO:0140269]; border follicle cell migration [GO:0007298]; follicle cell of egg chamber development [GO:0030707]; follicle cell of egg chamber-cell adhesion [GO:0007299]; germarium-derived egg chamber formation [GO:0007293]; glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; insect visual primordium formation [GO:0001744]; maintenance of polarity of follicular epithelium [GO:0042248]; morphogenesis of follicular epithelium [GO:0016333]	beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity [GO:0046981]; UDP-glycosyltransferase activity [GO:0008194]	Golgi membrane [GO:0000139]	GO:0000139; GO:0001744; GO:0006688; GO:0007293; GO:0007298; GO:0007299; GO:0008194; GO:0009101; GO:0016333; GO:0030707; GO:0042248; GO:0046981; GO:0140269
GN017629	GN017629.1	Q80U96	80.4	1067	1071	1071	0.0	1736	XPO1_RAT	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)	Rattus norvegicus (Rat)	cellular response to salt [GO:1902075]; cellular response to triglyceride [GO:0071401]; mRNA export from nucleus [GO:0006406]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611]; protein localization to nucleus [GO:0034504]; regulation of centrosome duplication [GO:0010824]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein catabolic process [GO:0042176]; regulation of protein export from nucleus [GO:0046825]; response to xenobiotic stimulus [GO:0009410]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; ribosomal subunit export from nucleus [GO:0000054]; ribosome biogenesis [GO:0042254]	DNA-binding transcription factor binding [GO:0140297]; nuclear export signal receptor activity [GO:0005049]; protein domain specific binding [GO:0019904]; small GTPase binding [GO:0031267]	annulate lamellae [GO:0005642]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]	GO:0000054; GO:0000055; GO:0000056; GO:0000122; GO:0000776; GO:0005049; GO:0005634; GO:0005642; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006406; GO:0006611; GO:0006913; GO:0009410; GO:0010824; GO:0015030; GO:0019904; GO:0031267; GO:0032434; GO:0032991; GO:0034504; GO:0042176; GO:0042254; GO:0046825; GO:0071401; GO:0140297; GO:1902075; GO:1990904
GN017630	GN017630.1	Q66KE9	34.4	465	741	647	3.19e-55	204	F161A_XENLA	Protein FAM161A	Xenopus laevis (African clawed frog)	cilium organization [GO:0044782]		centriole [GO:0005814]; ciliary basal body [GO:0036064]; photoreceptor connecting cilium [GO:0032391]	GO:0005814; GO:0032391; GO:0036064; GO:0044782
GN017631	GN017631.1	Q6DF46	50.9	454	471	464	3.94e-149	436	COQ6_XENTR	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.15.45) (2-methoxy-6-polyprenolphenol 4-hydroxylase) (EC 1.14.15.46) (Coenzyme Q10 monooxygenase 6)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	ubiquinone biosynthetic process [GO:0006744]	2-methoxy-6-polyprenolphenol 4-hydroxylase activity [GO:0120538]; 4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity [GO:0106364]; FAD binding [GO:0071949]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	extrinsic component of mitochondrial inner membrane [GO:0031314]; Golgi apparatus [GO:0005794]	GO:0005794; GO:0006744; GO:0016712; GO:0031314; GO:0071949; GO:0106364; GO:0120538
GN017633	GN017633.1	P43699	50.5	285	368	371	2.66e-55	188	NKX21_HUMAN	Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP)	Homo sapiens (Human)	brain development [GO:0007420]; cell differentiation [GO:0030154]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; forebrain development [GO:0030900]; gene expression [GO:0010467]; globus pallidus development [GO:0021759]; hypothalamus development [GO:0021854]; lung development [GO:0030324]; negative regulation of cell migration [GO:0030336]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hormone [GO:0009725]; thyroid gland development [GO:0030878]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; intronic transcription regulatory region sequence-specific DNA binding [GO:0001161]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000785; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0001161; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0006355; GO:0006357; GO:0007420; GO:0009725; GO:0010467; GO:0010628; GO:0010719; GO:0019899; GO:0021759; GO:0021854; GO:0030154; GO:0030324; GO:0030336; GO:0030512; GO:0030878; GO:0030900; GO:0042753; GO:0045892; GO:0045893; GO:0045944; GO:0060441; GO:0061629
GN017636	GN017636.1	Q498J9	41.4	203	466	233	7.83e-43	154	MBLC1_XENLA	Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1)	Xenopus laevis (African clawed frog)	histone mRNA metabolic process [GO:0008334]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0008334; GO:0046872; GO:1900087
GN017639	GN017639.1	O15381	38.6	396	412	856	1.39e-54	197	NVL_HUMAN	Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein)	Homo sapiens (Human)	positive regulation of protein binding [GO:0032092]; positive regulation of telomere maintenance [GO:0032206]; regulation of protein localization to nucleolus [GO:1904749]; ribosomal large subunit biogenesis [GO:0042273]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; telomerase holoenzyme complex assembly [GO:1905323]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275]; RNA binding [GO:0003723]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]	GO:0003723; GO:0005524; GO:0005634; GO:0005654; GO:0005697; GO:0005730; GO:0006364; GO:0016020; GO:0016887; GO:0032092; GO:0032206; GO:0042254; GO:0042273; GO:1904749; GO:1905323; GO:1990275
GN017643	GN017643.1	Q9DBY8	55.3	573	576	855	5.00e-186	548	NVL_MOUSE	Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein)	Mus musculus (Mouse)	positive regulation of protein binding [GO:0032092]; positive regulation of telomere maintenance [GO:0032206]; regulation of protein localization to nucleolus [GO:1904749]; ribosomal large subunit biogenesis [GO:0042273]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; telomerase holoenzyme complex assembly [GO:1905323]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275]	nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]	GO:0000176; GO:0005524; GO:0005634; GO:0005654; GO:0005697; GO:0005730; GO:0006364; GO:0016887; GO:0032092; GO:0032206; GO:0042254; GO:0042273; GO:1904749; GO:1905323; GO:1990275
GN017649	GN017649.1	Q9DBY8	77.0	74	89	855	2.05e-35	129	NVL_MOUSE	Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein)	Mus musculus (Mouse)	positive regulation of protein binding [GO:0032092]; positive regulation of telomere maintenance [GO:0032206]; regulation of protein localization to nucleolus [GO:1904749]; ribosomal large subunit biogenesis [GO:0042273]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; telomerase holoenzyme complex assembly [GO:1905323]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; preribosome binding [GO:1990275]	nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]	GO:0000176; GO:0005524; GO:0005634; GO:0005654; GO:0005697; GO:0005730; GO:0006364; GO:0016887; GO:0032092; GO:0032206; GO:0042254; GO:0042273; GO:1904749; GO:1905323; GO:1990275
GN017651	GN017651.1	P99029	47.3	165	193	210	3.30e-47	156	PRDX5_MOUSE	Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 2D-0014IV) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5)	Mus musculus (Mouse)	cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of transcription by RNA polymerase III [GO:0016480]; positive regulation of collagen biosynthetic process [GO:0032967]; reactive nitrogen species metabolic process [GO:2001057]; regulation of apoptosis involved in tissue homeostasis [GO:0060785]; response to oxidative stress [GO:0006979]	antioxidant activity [GO:0016209]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; peroxidase activity [GO:0004601]; peroxynitrite reductase activity [GO:0072541]; RNA polymerase III transcription regulatory region sequence-specific DNA binding [GO:0001016]; signaling receptor binding [GO:0005102]; thioredoxin peroxidase activity [GO:0008379]; thioredoxin-dependent peroxiredoxin activity [GO:0140824]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0001016; GO:0004601; GO:0005102; GO:0005634; GO:0005737; GO:0005739; GO:0005777; GO:0005782; GO:0005829; GO:0006979; GO:0008379; GO:0016209; GO:0016480; GO:0031410; GO:0032967; GO:0034599; GO:0034614; GO:0042744; GO:0042802; GO:0043027; GO:0043066; GO:0045454; GO:0048471; GO:0051354; GO:0060785; GO:0072541; GO:0140824; GO:2001057
GN017652	GN017652.1	Q5RET9	32.1	417	392	451	2.02e-51	181	SDE2_PONAB	Splicing regulator SDE2 (Replication stress response regulator SDE2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; mRNA cis splicing, via spliceosome [GO:0045292]	snoRNA binding [GO:0030515]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000479; GO:0005634; GO:0005737; GO:0030515; GO:0045292
GN017653	GN017653.1	Q3T0C9	61.2	85	192	145	1.47e-27	104	SYJ2B_BOVIN	Synaptojanin-2-binding protein (Activin receptor-interacting protein 2) (Mitochondrial outer membrane protein 25)	Bos taurus (Bovine)	negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of sprouting angiogenesis [GO:1903671]; regulation of Notch signaling pathway [GO:0008593]		mitochondrial outer membrane [GO:0005741]; perinuclear region of cytoplasm [GO:0048471]	GO:0001937; GO:0005741; GO:0008593; GO:0010596; GO:0016525; GO:0048471; GO:0070373; GO:1903671
GN017654	GN017654.1	P11352	60.0	140	143	201	1.98e-58	182	GPX1_MOUSE	Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) (Phospholipid-hydroperoxide glutathione peroxidase GPX1) (EC 1.11.1.12) (Selenium-dependent glutathione peroxidase 1)	Mus musculus (Mouse)	angiogenesis involved in wound healing [GO:0060055]; apoptotic process [GO:0006915]; arachidonate metabolic process [GO:0019369]; biological process involved in interaction with symbiont [GO:0051702]; blood vessel endothelial cell migration [GO:0043534]; cell population proliferation [GO:0008283]; cell redox homeostasis [GO:0045454]; cellular response to glucose stimulus [GO:0071333]; cellular response to oxidative stress [GO:0034599]; endothelial cell development [GO:0001885]; epigenetic regulation of gene expression [GO:0040029]; fat cell differentiation [GO:0045444]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide catabolic process [GO:0042744]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; lipid metabolic process [GO:0006629]; lipoxygenase pathway [GO:0019372]; myoblast proliferation [GO:0051450]; myotube differentiation [GO:0014902]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; neuron apoptotic process [GO:0051402]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; protein oxidation [GO:0018158]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of proteasomal protein catabolic process [GO:0061136]; response to estradiol [GO:0032355]; response to folic acid [GO:0051593]; response to gamma radiation [GO:0010332]; response to hormone [GO:0009725]; response to hydrogen peroxide [GO:0042542]; response to hydroperoxide [GO:0033194]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to oxidative stress [GO:0006979]; response to reactive oxygen species [GO:0000302]; response to selenium ion [GO:0010269]; response to symbiotic bacterium [GO:0009609]; response to toxic substance [GO:0009636]; response to vitamin E [GO:0033197]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]; skeletal muscle tissue regeneration [GO:0043403]; temperature homeostasis [GO:0001659]; triglyceride metabolic process [GO:0006641]; UV protection [GO:0009650]; vasodilation [GO:0042311]	glutathione peroxidase activity [GO:0004602]; peroxidase activity [GO:0004601]; phospholipid-hydroperoxide glutathione peroxidase activity [GO:0047066]; protein tyrosine kinase binding [GO:1990782]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Lewy body [GO:0097413]; mitochondrion [GO:0005739]	GO:0000302; GO:0001659; GO:0001885; GO:0002862; GO:0004601; GO:0004602; GO:0005737; GO:0005739; GO:0005829; GO:0006629; GO:0006641; GO:0006749; GO:0006915; GO:0006979; GO:0007605; GO:0008283; GO:0008631; GO:0009410; GO:0009609; GO:0009611; GO:0009636; GO:0009650; GO:0009725; GO:0010269; GO:0010332; GO:0014902; GO:0017124; GO:0018158; GO:0019369; GO:0019372; GO:0032355; GO:0032496; GO:0033194; GO:0033197; GO:0033599; GO:0034599; GO:0035094; GO:0040029; GO:0042311; GO:0042542; GO:0042744; GO:0043403; GO:0043534; GO:0045444; GO:0045454; GO:0047066; GO:0048741; GO:0051402; GO:0051450; GO:0051593; GO:0051702; GO:0051897; GO:0060047; GO:0060055; GO:0061136; GO:0071333; GO:0090201; GO:0097413; GO:1902042; GO:1902176; GO:1990782
GN017655	GN017655.1	Q9D2J7	46.5	785	782	775	4.47e-106	345	ANKE1_MOUSE	Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5)	Mus musculus (Mouse)				
GN017657	GN017657.1	Q8WUB8	46.4	466	843	498	6.56e-120	375	PHF10_HUMAN	PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; positive regulation of cell differentiation [GO:0045597]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of T cell differentiation [GO:0045582]; regulation of G0 to G1 transition [GO:0070316]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]; transcription coregulator activity [GO:0003712]	chromatin [GO:0000785]; kinetochore [GO:0000776]; npBAF complex [GO:0071564]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; RSC-type complex [GO:0016586]; SWI/SNF complex [GO:0016514]	GO:0000776; GO:0000785; GO:0003682; GO:0003712; GO:0005654; GO:0006338; GO:0006357; GO:0016363; GO:0016514; GO:0016586; GO:0030071; GO:0045582; GO:0045597; GO:0045663; GO:0070316; GO:0071564; GO:1902459; GO:2000045; GO:2000781; GO:2000819
GN017661	GN017661.1	Q8TBZ3	53.5	576	576	569	1.05e-202	580	WDR20_HUMAN	WD repeat-containing protein 20 (Protein DMR)	Homo sapiens (Human)	negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of canonical Wnt signaling pathway [GO:0090263]	deubiquitinase activator activity [GO:0035800]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peptidase complex [GO:1905368]; plasma membrane [GO:0005886]	GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0035800; GO:0090263; GO:1905368; GO:2000059
GN017664	GN017664.1	Q9BLC5	79.6	608	608	716	0.0	896	HSP83_BOMMO	Heat shock protein 83 (BmHSP90)	Bombyx mori (Silk moth)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]	cytoplasm [GO:0005737]; protein folding chaperone complex [GO:0101031]	GO:0005524; GO:0005737; GO:0016887; GO:0101031; GO:0140662
GN017665	GN017665.1	Q9M2U3	25.4	334	390	406	5.95e-23	102	ALPL_ARATH	Protein ALP1-like (EC 3.1.-.-)	Arabidopsis thaliana (Mouse-ear cress)			histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634
GN017666	GN017666.1	P54366	86.4	66	236	415	6.73e-28	112	GSC_DROME	Homeobox protein goosecoid	Drosophila melanogaster (Fruit fly)	negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0001227; GO:0005634; GO:0006357; GO:0042803; GO:0045892; GO:0046982
GN017668	GN017668.1	P35500	56.5	306	404	2131	3.54e-89	298	SCNA_DROME	Sodium channel protein para (Protein paralytic) (Sodium channel 1) (DmNav1)	Drosophila melanogaster (Fruit fly)	male courtship behavior, veined wing generated song production [GO:0045433]; mechanosensory behavior [GO:0007638]; membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]; regulation of postsynaptic membrane potential [GO:0060078]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; sensory perception of pain [GO:0019233]; sensory perception of sound [GO:0007605]; sodium ion transmembrane transport [GO:0035725]	calcium ion binding [GO:0005509]; sodium channel activity [GO:0005272]; voltage-gated sodium channel activity [GO:0005248]	plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518]	GO:0001518; GO:0001666; GO:0005248; GO:0005272; GO:0005509; GO:0005886; GO:0007605; GO:0007638; GO:0009612; GO:0019228; GO:0019233; GO:0035725; GO:0045433; GO:0060078; GO:0086010
GN017682	GN017682.1	Q9MA55	27.2	268	479	668	5.80e-21	99.8	ACBP4_ARATH	Acyl-CoA-binding domain-containing protein 4 (Acyl-CoA binding protein 4)	Arabidopsis thaliana (Mouse-ear cress)	lipid transport [GO:0006869]; response to ethylene [GO:0009723]; response to jasmonic acid [GO:0009753]; response to light stimulus [GO:0009416]	fatty-acyl-CoA binding [GO:0000062]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0000062; GO:0005737; GO:0005829; GO:0006869; GO:0009416; GO:0009723; GO:0009753
GN017684	GN017684.1	Q9VQ93	71.4	297	288	294	4.49e-145	412	GOLP3_DROME	Golgi phosphoprotein 3 homolog sauron (Protein rotini)	Drosophila melanogaster (Fruit fly)	actomyosin contractile ring assembly [GO:0000915]; cleavage furrow formation [GO:0036089]; Golgi organization [GO:0007030]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle budding [GO:0048194]; male meiosis cytokinesis [GO:0007112]; meiosis I cytokinesis [GO:0007110]; meiosis II cytokinesis [GO:0007111]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly [GO:0090307]; protein targeting to Golgi apparatus [GO:0140450]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; spindle assembly [GO:0051225]; spindle assembly involved in male meiosis [GO:0007053]; symbiont entry into host cell [GO:0046718]	cargo adaptor activity [GO:0140312]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; small GTPase binding [GO:0031267]	cleavage furrow [GO:0032154]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0000281; GO:0000301; GO:0000915; GO:0005794; GO:0005802; GO:0005829; GO:0006890; GO:0007030; GO:0007053; GO:0007110; GO:0007111; GO:0007112; GO:0010314; GO:0031267; GO:0031410; GO:0031985; GO:0032154; GO:0032266; GO:0036089; GO:0043001; GO:0046718; GO:0048194; GO:0051225; GO:0070273; GO:0070300; GO:0090307; GO:0140312; GO:0140450
GN017686	GN017686.1	Q8IV20	35.9	354	352	430	3.09e-69	226	LACC1_HUMAN	Purine nucleoside phosphorylase LACC1 (EC 2.4.2.1) (Adenosine deaminase LACC1) (EC 3.5.4.4) (Fatty acid metabolism-immunity nexus) (Guanosine phosphorylase LACC1) (Isocyanic acid synthase) (EC 4.3.3.-) (Laccase domain-containing protein 1) (S-methyl-5'-thioadenosine phosphorylase LACC1) (EC 2.4.2.28)	Homo sapiens (Human)	nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; pattern recognition receptor signaling pathway [GO:0002221]; positive regulation of cytokine production involved in immune response [GO:0002720]; regulation of inflammatory response [GO:0050727]; regulation of intracellular pH [GO:0051453]; regulation of purine nucleotide metabolic process [GO:1900542]	adenosine deaminase activity [GO:0004000]; copper ion binding [GO:0005507]; guanosine phosphorylase activity [GO:0047975]; purine-nucleoside phosphorylase activity [GO:0004731]; S-methyl-5-thioadenosine phosphorylase activity [GO:0017061]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; peroxisome [GO:0005777]	GO:0002221; GO:0002720; GO:0004000; GO:0004731; GO:0005507; GO:0005634; GO:0005737; GO:0005777; GO:0005783; GO:0017061; GO:0047975; GO:0050727; GO:0051453; GO:0070431; GO:1900542
GN017688	GN017688.1	Q8HY24	36.1	97	127	542	6.21e-18	81.6	S22A8_RABIT	Organic anion transporter 3 (rOAT3) (Organic anion/dicarboxylate exchanger) (Solute carrier family 22 member 8)	Oryctolagus cuniculus (Rabbit)	prostaglandin transport [GO:0015732]	antiporter activity [GO:0015297]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	basolateral plasma membrane [GO:0016323]	GO:0015297; GO:0015732; GO:0016323; GO:0022857; GO:0042910
GN017691	GN017691.1	Q9ULT8	52.5	2239	2080	2610	0.0	2094	HECD1_HUMAN	E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)	Homo sapiens (Human)	aorta development [GO:0035904]; heart valve development [GO:0003170]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular septum development [GO:0003281]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0003170; GO:0003281; GO:0005654; GO:0005730; GO:0006511; GO:0016567; GO:0032436; GO:0035904; GO:0046872; GO:0061630
GN017700	GN017700.1	A3KP37	49.5	303	315	321	3.84e-99	297	NDUF5_DANRE	Arginine-hydroxylase NDUFAF5, mitochondrial (EC 1.-.-.-) (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5) (Putative methyltransferase NDUFAF5) (EC 2.1.1.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	mitochondrial respiratory chain complex I assembly [GO:0032981]	S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0008757; GO:0032981
GN017709	GN017709.1	Q40251	31.6	247	238	473	4.26e-26	108	VDE_LACSA	Violaxanthin de-epoxidase, chloroplastic (EC 1.23.5.1)	Lactuca sativa (Garden lettuce)	xanthophyll cycle [GO:0010028]	violaxanthin de-epoxidase activity [GO:0046422]	chloroplast thylakoid membrane [GO:0009535]	GO:0009535; GO:0010028; GO:0046422
GN017713	GN017713.1	O00548	55.2	326	788	723	6.83e-77	266	DLL1_HUMAN	Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1)	Homo sapiens (Human)	astrocyte development [GO:0014002]; cell differentiation [GO:0030154]; cell fate determination [GO:0001709]; cerebellar molecular layer formation [GO:0021688]; cerebellar Purkinje cell layer structural organization [GO:0021693]; clathrin-dependent endocytosis [GO:0072583]; determination of left/right symmetry [GO:0007368]; endothelial tip cell fate specification [GO:0097102]; energy homeostasis [GO:0097009]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; lateral inhibition [GO:0046331]; left/right axis specification [GO:0070986]; loop of Henle development [GO:0072070]; marginal zone B cell differentiation [GO:0002315]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epidermal cell differentiation [GO:0045605]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of Notch signaling pathway [GO:0045746]; nephron development [GO:0072006]; neuron fate specification [GO:0048665]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in arterial endothelial cell fate commitment [GO:0060853]; organ growth [GO:0035265]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endocytosis [GO:0045807]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal tubule development [GO:0072014]; proximal/distal pattern formation [GO:0009954]; regulation of blood pressure [GO:0008217]; regulation of cell adhesion [GO:0030155]; regulation of cell division [GO:0051302]; regulation of growth [GO:0040008]; regulation of neurogenesis [GO:0050767]; regulation of skeletal muscle tissue growth [GO:0048631]; regulation of somitogenesis [GO:0014807]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746]; retina development in camera-type eye [GO:0060041]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal muscle tissue growth [GO:0048630]; skin epidermis development [GO:0098773]; somitogenesis [GO:0001756]; spinal cord development [GO:0021510]; type B pancreatic cell development [GO:0003323]	calcium ion binding [GO:0005509]; Notch binding [GO:0005112]; receptor ligand activity [GO:0048018]; scaffold protein binding [GO:0097110]; Tat protein binding [GO:0030957]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0001709; GO:0001756; GO:0001947; GO:0002315; GO:0003323; GO:0005112; GO:0005509; GO:0005576; GO:0005886; GO:0005912; GO:0007219; GO:0007368; GO:0008217; GO:0008284; GO:0008285; GO:0009954; GO:0010628; GO:0014002; GO:0014807; GO:0016324; GO:0021510; GO:0021688; GO:0021693; GO:0030097; GO:0030154; GO:0030155; GO:0030857; GO:0030947; GO:0030957; GO:0031410; GO:0032693; GO:0034351; GO:0035265; GO:0040008; GO:0045121; GO:0045596; GO:0045605; GO:0045662; GO:0045665; GO:0045746; GO:0045747; GO:0045807; GO:0045944; GO:0046331; GO:0048018; GO:0048630; GO:0048631; GO:0048633; GO:0048665; GO:0050767; GO:0051302; GO:0060041; GO:0060042; GO:0060853; GO:0070986; GO:0072006; GO:0072014; GO:0072070; GO:0072583; GO:0097009; GO:0097102; GO:0097110; GO:0097150; GO:0098773; GO:1900746; GO:1903672; GO:2000726
GN017715	GN017715.1	E7F594	46.5	142	194	373	1.44e-31	120	G137B_DANRE	G protein-coupled receptor 137Ba	Danio rerio (Zebrafish) (Brachydanio rerio)	bone remodeling [GO:0046849]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of protein localization to lysosome [GO:0150032]; positive regulation of TORC1 signaling [GO:1904263]; regulation of autophagy [GO:0010506]; regulation of GTPase activity [GO:0043087]; regulation of lysosome size [GO:0062196]		lysosomal membrane [GO:0005765]	GO:0005765; GO:0010506; GO:0043087; GO:0045671; GO:0045779; GO:0046849; GO:0062196; GO:0150032; GO:1904263
GN017716	GN017716.1	Q5ZKA2	45.3	935	939	1000	1.24e-275	796	SYIM_CHICK	Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)	Gallus gallus (Chicken)	isoleucyl-tRNA aminoacylation [GO:0006428]; mitochondrial translation [GO:0032543]	aminoacyl-tRNA deacylase activity [GO:0002161]; ATP binding [GO:0005524]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0000049; GO:0002161; GO:0004822; GO:0005524; GO:0005739; GO:0005759; GO:0006428; GO:0032543
GN017717	GN017717.1	Q9CXE6	42.9	333	326	349	6.47e-72	229	XRCC3_MOUSE	DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3)	Mus musculus (Mouse)	DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of centrosome duplication [GO:0010824]; replication fork processing [GO:0031297]; resolution of mitotic recombination intermediates [GO:0071140]; t-circle formation [GO:0090656]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomere trimming [GO:0090737]	ATP binding [GO:0005524]; ATP-dependent DNA damage sensor activity [GO:0140664]; crossover junction DNA endonuclease activity [GO:0008821]; four-way junction DNA binding [GO:0000400]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Rad51C-XRCC3 complex [GO:0033065]; replication fork [GO:0005657]	GO:0000400; GO:0000722; GO:0000724; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006281; GO:0008821; GO:0010824; GO:0031297; GO:0033065; GO:0036297; GO:0043596; GO:0048471; GO:0071140; GO:0090267; GO:0090656; GO:0090737; GO:0140664
GN017718	GN017718.1	P15043	36.9	84	110	609	4.40e-10	58.5	RECQ_ECOLI	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Escherichia coli (strain K12)	DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; G-quadruplex unwinding activity [GO:0160225]; single-stranded DNA helicase activity [GO:0017116]; transition metal ion binding [GO:0046914]; zinc ion binding [GO:0008270]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]; single-stranded DNA-dependent ATP-dependent DNA helicase complex [GO:0017117]	GO:0003677; GO:0003678; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0006974; GO:0008094; GO:0008270; GO:0009432; GO:0016887; GO:0017116; GO:0017117; GO:0030894; GO:0043138; GO:0043590; GO:0046914; GO:0160225
GN017722	GN017722.1	Q96LQ0	33.0	318	399	422	3.34e-37	142	PPR36_HUMAN	Protein phosphatase 1 regulatory subunit 36	Homo sapiens (Human)		phosphatase binding [GO:0019902]		GO:0019902
GN017723	GN017723.1	P17439	51.7	497	511	515	3.05e-174	503	GBA1_MOUSE	Lysosomal acid glucosylceramidase (Lysosomal acid GCase) (EC 3.2.1.45) (Acid beta-glucosidase) (Beta-glucocerebrosidase) (Cholesterol glucosyltransferase) (SGTase) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase) (EC 3.2.1.-) (D-glucosyl-N-acylsphingosine glucohydrolase) (Lysosomal cholesterol glycosyltransferase) (Lysosomal galactosylceramidase) (EC 3.2.1.46) (Lysosomal glycosylceramidase)	Mus musculus (Mouse)	antigen processing and presentation [GO:0019882]; autophagosome organization [GO:1905037]; autophagy [GO:0006914]; beta-glucoside catabolic process [GO:1901805]; brain morphogenesis [GO:0048854]; cell maturation [GO:0048469]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; central nervous system development [GO:0007417]; ceramide biosynthetic process [GO:0046513]; cerebellar Purkinje cell layer formation [GO:0021694]; cholesterol metabolic process [GO:0008203]; determination of adult lifespan [GO:0008340]; establishment of skin barrier [GO:0061436]; glucosylceramide catabolic process [GO:0006680]; glucosylceramide metabolic process [GO:0006678]; glycolipid biosynthetic process [GO:0009247]; hematopoietic stem cell proliferation [GO:0071425]; homeostasis of number of cells [GO:0048872]; lipid storage [GO:0019915]; lymphocyte migration [GO:0072676]; lysosomal protein catabolic process [GO:1905146]; lysosome organization [GO:0007040]; microglia differentiation [GO:0014004]; microglial cell proliferation [GO:0061518]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; motor behavior [GO:0061744]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of protein-containing complex assembly [GO:0031333]; nervous system process [GO:0050877]; neuromuscular process [GO:0050905]; neuron apoptotic process [GO:0051402]; positive regulation of neuronal action potential [GO:1904457]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of type 2 mitophagy [GO:1905091]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; pyramidal neuron differentiation [GO:0021859]; regulation of membrane potential [GO:0042391]; regulation of protein metabolic process [GO:0051246]; regulation of TOR signaling [GO:0032006]; respiratory electron transport chain [GO:0022904]; response to dexamethasone [GO:0071548]; response to estrogen [GO:0043627]; response to pH [GO:0009268]; response to testosterone [GO:0033574]; response to thyroid hormone [GO:0097066]; skin epidermis development [GO:0098773]; sphingosine biosynthetic process [GO:0046512]; T cell differentiation in thymus [GO:0033077]; termination of signal transduction [GO:0023021]	beta-glucosidase activity [GO:0008422]; galactosylceramidase activity [GO:0004336]; glucosylceramidase activity [GO:0004348]; glucosyltransferase activity [GO:0046527]; hydrolase activity [GO:0016787]; scavenger receptor binding [GO:0005124]; signaling receptor binding [GO:0005102]; steryl-beta-glucosidase activity [GO:0050295]	endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; trans-Golgi network [GO:0005802]	GO:0000423; GO:0004336; GO:0004348; GO:0005102; GO:0005124; GO:0005576; GO:0005764; GO:0005765; GO:0005783; GO:0005794; GO:0005802; GO:0006678; GO:0006680; GO:0006914; GO:0007005; GO:0007040; GO:0007417; GO:0008203; GO:0008340; GO:0008422; GO:0009247; GO:0009267; GO:0009268; GO:0014004; GO:0016787; GO:0019882; GO:0019915; GO:0021694; GO:0021859; GO:0022904; GO:0023021; GO:0031333; GO:0032006; GO:0032436; GO:0032715; GO:0033077; GO:0033574; GO:0042391; GO:0043161; GO:0043202; GO:0043409; GO:0043524; GO:0043627; GO:0046512; GO:0046513; GO:0046527; GO:0048469; GO:0048854; GO:0048872; GO:0050295; GO:0050728; GO:0050877; GO:0050905; GO:0051246; GO:0051248; GO:0051402; GO:0061436; GO:0061518; GO:0061744; GO:0071356; GO:0071425; GO:0071548; GO:0072676; GO:0097066; GO:0098773; GO:1901805; GO:1904457; GO:1905037; GO:1905091; GO:1905146
GN017724	GN017724.1	Q8BUN9	47.5	358	356	666	1.01e-86	278	NCKX2_MOUSE	Sodium/potassium/calcium exchanger 2 (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2)	Mus musculus (Mouse)	calcium ion import [GO:0070509]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to high light intensity [GO:0071486]; cone photoresponse recovery [GO:0036368]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; monoatomic ion transmembrane transport [GO:0034220]; phototransduction [GO:0007602]; potassium ion transmembrane transport [GO:0071805]; protein-containing complex assembly [GO:0065003]; sodium ion transmembrane transport [GO:0035725]	calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]	membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]	GO:0005262; GO:0005886; GO:0006816; GO:0006874; GO:0007602; GO:0007612; GO:0007613; GO:0008273; GO:0016020; GO:0034220; GO:0035725; GO:0036368; GO:0060291; GO:0060292; GO:0065003; GO:0070509; GO:0070588; GO:0071486; GO:0071805; GO:0098703; GO:0098793; GO:0098794
GN017725	GN017725.1	Q96SY0	52.7	524	511	518	2.42e-184	529	INT14_HUMAN	Integrator complex subunit 14 (von Willebrand factor A domain-containing protein 9)	Homo sapiens (Human)	regulation of transcription elongation by RNA polymerase II [GO:0034243]; RNA polymerase II transcription initiation surveillance [GO:0160240]; snRNA 3'-end processing [GO:0034472]; snRNA processing [GO:0016180]		INTAC complex [GO:0160232]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0016180; GO:0032039; GO:0034243; GO:0034472; GO:0160232; GO:0160240
GN017727	GN017727.1	Q969U6	31.7	587	630	566	1.31e-72	247	FBXW5_HUMAN	F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)	Homo sapiens (Human)	centrosome duplication [GO:0051298]; cilium assembly [GO:0060271]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	protein kinase binding [GO:0019901]	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005737; GO:0005829; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0051298; GO:0060271; GO:0080008
GN017728	GN017728.1	Q5W8I7	35.9	304	405	587	1.52e-60	209	VGL2B_DANRE	Vesicular glutamate transporter 2.2 (Solute carrier family 17 member 6-A) (Vesicular glutamate transporter 2-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	L-glutamate import [GO:0051938]; L-glutamate transmembrane transport [GO:0015813]; neurotransmitter loading into synaptic vesicle [GO:0098700]; phosphate ion homeostasis [GO:0055062]; phosphate ion transport [GO:0006817]; regulation of synapse structure or activity [GO:0050803]; sensory perception [GO:0007600]; sodium-dependent phosphate transport [GO:0044341]; synaptic transmission, glutamatergic [GO:0035249]	chloride channel activity [GO:0005254]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamate uniporter activity [GO:0140788]; neurotransmitter transmembrane transporter activity [GO:0005326]; potassium:proton antiporter activity [GO:0015386]; sodium:phosphate symporter activity [GO:0005436]	excitatory synapse [GO:0060076]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	GO:0005254; GO:0005313; GO:0005326; GO:0005436; GO:0005886; GO:0006817; GO:0007600; GO:0008021; GO:0015386; GO:0015813; GO:0030672; GO:0035249; GO:0043005; GO:0044341; GO:0050803; GO:0051938; GO:0055062; GO:0060076; GO:0098700; GO:0140788
GN017732	GN017732.1	Q8IR45	48.9	88	114	183	1.47e-22	89.7	BORC8_DROME	BLOC-1-related complex subunit 8 homolog	Drosophila melanogaster (Fruit fly)	lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384]		BORC complex [GO:0099078]; cytoplasmic side of lysosomal membrane [GO:0098574]; lysosomal membrane [GO:0005765]	GO:0005765; GO:0032418; GO:0072384; GO:0098574; GO:0099078
GN017733	GN017733.1	P19483	83.9	534	544	553	8.80e-312	855	ATPA_BOVIN	ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha)	Bos taurus (Bovine)	proton motive force-driven ATP synthesis [GO:0015986]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex [GO:0045259]	GO:0005524; GO:0005739; GO:0005743; GO:0005886; GO:0015986; GO:0043531; GO:0045259; GO:0046933
GN017737	GN017737.1	Q8K4Q7	42.5	179	260	531	6.65e-42	153	CERK1_MOUSE	Ceramide kinase (mCERK) (EC 2.7.1.138) (Acylsphingosine kinase)	Mus musculus (Mouse)	ceramide metabolic process [GO:0006672]	ceramide kinase activity [GO:0001729]; magnesium ion binding [GO:0000287]	cytoplasm [GO:0005737]; cytoplasmic side of trans-Golgi network membrane [GO:0160281]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0000287; GO:0001729; GO:0005737; GO:0005739; GO:0005886; GO:0006672; GO:0016020; GO:0160281
GN017740	GN017740.1	Q7TPQ9	27.8	367	468	414	1.16e-38	148	ARRD3_MOUSE	Arrestin domain-containing protein 3	Mus musculus (Mouse)	fat pad development [GO:0060613]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of heat generation [GO:0031651]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; positive regulation of hippo signaling [GO:0035332]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; response to mechanical stimulus [GO:0009612]; skin development [GO:0043588]; temperature homeostasis [GO:0001659]	beta-3 adrenergic receptor binding [GO:0031699]; molecular adaptor activity [GO:0060090]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0001659; GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0009612; GO:0031651; GO:0031699; GO:0035332; GO:0043588; GO:0051443; GO:0060090; GO:0060613; GO:0071878; GO:0090327; GO:0120163
GN017742	GN017742.1	Q5ZK44	45.9	340	359	416	9.45e-80	253	ARB2A_CHICK	Cotranscriptional regulator ARB2A homolog (Cotranscriptional regulator FAM172A homolog) (Protein FAM172A)	Gallus gallus (Chicken)	regulatory ncRNA-mediated heterochromatin formation [GO:0031048]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005829; GO:0031048
GN017743	GN017743.1	Q3U1V8	66.5	218	236	1077	1.05e-94	302	M3K9_MOUSE	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25)	Mus musculus (Mouse)	positive regulation of apoptotic process [GO:0043065]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; molecular function activator activity [GO:0140677]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]	GO:0004674; GO:0004706; GO:0005524; GO:0005737; GO:0006468; GO:0043065; GO:0046777; GO:0106310; GO:0140677
GN017744	GN017744.1	Q13405	43.2	111	111	166	1.10e-23	92.0	RM49_HUMAN	Large ribosomal subunit protein mL49 (39S ribosomal protein L49, mitochondrial) (L49mt) (MRP-L49) (Neighbor of FAU) (NOF) (Protein NOF1)	Homo sapiens (Human)	mitochondrial translation [GO:0032543]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005761; GO:0005762; GO:0032543
GN017746	GN017746.1	P55264	49.1	344	348	361	2.52e-105	316	ADK_MOUSE	Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) (N6,N6-dimethyladenosine kinase) (EC 2.7.1.-) (N6-isopentenyladenosine kinase) (EC 2.7.1.-) (N6-methyladenosine kinase) (EC 2.7.1.-)	Mus musculus (Mouse)	adenosine metabolic process [GO:0046085]; AMP salvage [GO:0044209]; dATP biosynthetic process [GO:0006175]; GMP salvage [GO:0032263]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of T cell proliferation [GO:0042102]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide salvage [GO:0032261]; purine ribonucleoside salvage [GO:0006166]; toxic metabolite repair [GO:0110052]; type B pancreatic cell proliferation [GO:0044342]	adenosine kinase activity [GO:0004001]; deoxyadenosine kinase activity [GO:0004136]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0004001; GO:0004136; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006144; GO:0006166; GO:0006175; GO:0010613; GO:0032261; GO:0032263; GO:0042102; GO:0044209; GO:0044342; GO:0046085; GO:0110052
GN017747	GN017747.1	Q92056	25.9	379	410	346	1.86e-37	142	ASMT_CHICK	Acetylserotonin O-methyltransferase (EC 2.1.1.4) (Hydroxyindole O-methyltransferase) (HIOMT)	Gallus gallus (Chicken)	melatonin biosynthetic process [GO:0030187]; methylation [GO:0032259]	acetylserotonin O-methyltransferase activity [GO:0017096]; protein dimerization activity [GO:0046983]		GO:0017096; GO:0030187; GO:0032259; GO:0046983
GN017748	GN017748.1	A0A0F7YYX3	33.8	195	191	196	3.86e-27	104	CPROH_CONVC	Neuropeptide prohormone-4	Conus victoriae (Queen Victoria cone)			extracellular region [GO:0005576]	GO:0005576
GN017749	GN017749.1	A5D6U8	56.9	413	428	443	7.67e-168	481	ACP7_DANRE	Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form)	Danio rerio (Zebrafish) (Brachydanio rerio)		acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872]	extracellular region [GO:0005576]	GO:0003993; GO:0005576; GO:0046872
GN017751	GN017751.1	Q91ZN5	77.8	45	69	431	8.58e-16	72.8	S35B2_MOUSE	Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (Solute carrier family 35 member B2)	Mus musculus (Mouse)	3'-phosphoadenosine 5'-phosphosulfate transport [GO:0046963]; 5'-adenylyl sulfate transmembrane transport [GO:1902558]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; peptidyl-tyrosine sulfation [GO:0006478]	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0005794; GO:0005802; GO:0006478; GO:0016020; GO:0046963; GO:0046964; GO:0050650; GO:1902558
GN017753	GN017753.1	Q2YDE4	81.3	246	246	246	2.20e-146	411	PSA6_BOVIN	Proteasome subunit alpha type-6	Bos taurus (Bovine)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]	GO:0000932; GO:0005634; GO:0005737; GO:0005829; GO:0005839; GO:0019773; GO:0043161
GN017759	GN017759.1	Q9Y3Q0	46.5	703	755	740	8.80e-211	614	NALD2_HUMAN	N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II)	Homo sapiens (Human)	proteolysis [GO:0006508]	carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; dipeptidyl-peptidase activity [GO:0008239]; metallocarboxypeptidase activity [GO:0004181]; N-formylglutamate deformylase activity [GO:0050129]; serine-type peptidase activity [GO:0008236]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004180; GO:0004181; GO:0005886; GO:0006508; GO:0008236; GO:0008239; GO:0016020; GO:0016805; GO:0050129
GN017760	GN017760.1	A2ARS0	42.0	112	287	390	6.33e-16	80.5	ANR63_MOUSE	Ankyrin repeat domain-containing protein 63	Mus musculus (Mouse)				
GN017764	GN017764.1	Q6DRL4	21.5	885	1564	1824	3.15e-14	82.4	TICRR_DANRE	Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA repair [GO:0006281]; DNA replication [GO:0006260]; mitotic DNA replication checkpoint signaling [GO:0033314]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; regulation of DNA-templated DNA replication initiation [GO:0030174]; response to ionizing radiation [GO:0010212]	chromatin binding [GO:0003682]	nucleus [GO:0005634]	GO:0003682; GO:0005634; GO:0006260; GO:0006281; GO:0007095; GO:0010212; GO:0030174; GO:0033314
GN017768	GN017768.1	P12261	55.5	281	276	430	8.01e-98	296	EF1G_ARTSA	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)	Artemia salina (Brine shrimp)		translation elongation factor activity [GO:0003746]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003746; GO:0005634; GO:0005737
GN017769	GN017769.1	G5EBQ8	33.9	1540	1564	1668	4.31e-220	694	CHS2_CAEEL	Chitin synthase chs-2 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase chs-2)	Caenorhabditis elegans	chitin biosynthetic process [GO:0006031]; positive regulation of nematode larval development [GO:0061063]	chitin synthase activity [GO:0004100]	plasma membrane [GO:0005886]	GO:0004100; GO:0005886; GO:0006031; GO:0061063
GN017770	GN017770.1	A6NNM8	58.0	550	983	815	3.54e-217	642	TTL13_HUMAN	Tubulin polyglutamylase TTLL13 (EC 6.3.2.-) (Tubulin tyrosine ligase like 13) (Tubulin tyrosine ligase-like family member 13 pseudogene) (Tubulin--tyrosine ligase-like protein 13)	Homo sapiens (Human)	microtubule bundle formation [GO:0001578]; protein polyglutamylation [GO:0018095]	protein-glutamic acid ligase activity, elongating [GO:0106438]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]	ciliary basal body [GO:0036064]; cytosol [GO:0005829]; spindle pole [GO:0000922]	GO:0000922; GO:0001578; GO:0005829; GO:0015631; GO:0018095; GO:0036064; GO:0070740; GO:0106438
GN017771	GN017771.1	Q9D2C9	38.8	348	384	407	8.92e-76	243	SNPC3_MOUSE	snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Small nuclear RNA-activating complex polypeptide 3)	Mus musculus (Mouse)	snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]	bent DNA binding [GO:0003681]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]	nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; snRNA-activating protein complex [GO:0019185]	GO:0001006; GO:0003681; GO:0005654; GO:0005730; GO:0016604; GO:0019185; GO:0042795; GO:0042796
GN017773	GN017773.1	Q04164	25.9	317	1110	1693	2.90e-17	91.7	SAS_DROME	Putative epidermal cell surface receptor (Stranded at second protein)	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell signaling via exosome [GO:0099156]; instar larval development [GO:0002168]; positive regulation of cell differentiation [GO:0045597]	integrin binding [GO:0005178]; membrane-membrane adaptor activity [GO:0140177]; molecular adaptor activity [GO:0060090]; signaling receptor activity [GO:0038023]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	GO:0002168; GO:0005178; GO:0005886; GO:0007155; GO:0007411; GO:0016324; GO:0038023; GO:0045597; GO:0060090; GO:0070062; GO:0099156; GO:0140177
GN017775	GN017775.1	O14646	58.2	1325	1835	1710	0.0	1432	CHD1_HUMAN	ATP-dependent chromatin remodeler CHD1 (EC 3.6.4.-) (Chromo domain-containing protein 1) (CHD-1)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; host-mediated activation of viral transcription [GO:0043923]; nucleosome organization [GO:0034728]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; histone binding [GO:0042393]; histone H3K4me3 reader activity [GO:0140002]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000228; GO:0000785; GO:0003677; GO:0003682; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006338; GO:0016887; GO:0034728; GO:0042393; GO:0043923; GO:0140002; GO:0140658
GN017776	GN017776.1	Q6NWD4	46.9	288	439	387	2.20e-77	248	TIM50_DANRE	Mitochondrial import inner membrane translocase subunit TIM50	Danio rerio (Zebrafish) (Brachydanio rerio)	apoptotic process [GO:0006915]; mitochondrial membrane organization [GO:0007006]; protein import into mitochondrial matrix [GO:0030150]		mitochondrial inner membrane [GO:0005743]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]	GO:0005743; GO:0005744; GO:0006915; GO:0007006; GO:0030150
GN017778	GN017778.1	Q6P3Z3	50.0	62	223	569	1.94e-11	66.2	THAP4_MOUSE	Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric nitrobindin) (Nb(III)) (THAP domain-containing protein 4)	Mus musculus (Mouse)	cellular response to reactive nitrogen species [GO:1902170]; nitrate metabolic process [GO:0042126]	heme binding [GO:0020037]; identical protein binding [GO:0042802]; nitric oxide binding [GO:0070026]; peroxynitrite isomerase activity [GO:0062213]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0020037; GO:0042126; GO:0042802; GO:0062213; GO:0070026; GO:1902170
GN017779	GN017779.1	P15043	35.7	84	110	609	3.89e-09	55.8	RECQ_ECOLI	ATP-dependent DNA helicase RecQ (EC 5.6.2.4) (DNA 3'-5' helicase RecQ)	Escherichia coli (strain K12)	DNA damage response [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; G-quadruplex unwinding activity [GO:0160225]; single-stranded DNA helicase activity [GO:0017116]; transition metal ion binding [GO:0046914]; zinc ion binding [GO:0008270]	bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]; single-stranded DNA-dependent ATP-dependent DNA helicase complex [GO:0017117]	GO:0003677; GO:0003678; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0006974; GO:0008094; GO:0008270; GO:0009432; GO:0016887; GO:0017116; GO:0017117; GO:0030894; GO:0043138; GO:0043590; GO:0046914; GO:0160225
GN017783	GN017783.1	Q5SPB6	41.6	178	193	196	6.06e-39	135	CHAC1_DANRE	Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 4.3.2.7) (Cation transport regulator-like protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	glutathione catabolic process [GO:0006751]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein processing [GO:0010955]; neurogenesis [GO:0022008]	glutathione specific gamma-glutamylcyclotransferase activity [GO:0061928]; Notch binding [GO:0005112]	cytosol [GO:0005829]; trans-Golgi network [GO:0005802]	GO:0005112; GO:0005802; GO:0005829; GO:0006751; GO:0010955; GO:0022008; GO:0045746; GO:0061928
GN017785	GN017785.1	Q86TV6	39.3	849	835	843	2.76e-179	540	TTC7B_HUMAN	Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1)	Homo sapiens (Human)	phosphatidylinositol phosphate biosynthetic process [GO:0046854]; protein localization to plasma membrane [GO:0072659]		cytosol [GO:0005829]; plasma membrane [GO:0005886]	GO:0005829; GO:0005886; GO:0046854; GO:0072659
GN017786	GN017786.1	Q8CHK4	60.8	497	455	513	2.32e-198	562	KAT5_MOUSE	Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (Protein lactyltransferase KAT5) (EC 2.3.1.-)	Mus musculus (Mouse)	aggrephagy [GO:0035973]; apoptotic process [GO:0006915]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cGAS/STING signaling pathway [GO:0140896]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA double-strand break processing [GO:0000729]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of mitotic spindle orientation [GO:0000132]; lipid droplet disassembly [GO:1905691]; membraneless organelle assembly [GO:0140694]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; nucleotide-excision repair [GO:0006289]; peptidyl-lysine acetylation [GO:0018394]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; positive regulation of aggrephagy [GO:1905337]; positive regulation of attachment of mitotic spindle microtubules to kinetochore [GO:1902425]; positive regulation of autophagy [GO:0010508]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of innate immune response [GO:0045089]; positive regulation of mitotic sister chromatid segregation [GO:0062033]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of protein acetylation [GO:1901985]; positive regulation of regulatory T cell differentiation [GO:0045591]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein acetylation [GO:0006473]; protein localization to site of double-strand break [GO:1990166]; protein targeting to vacuole involved in autophagy [GO:0071211]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromatin organization [GO:1902275]; regulation of double-strand break repair [GO:2000779]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ionizing radiation [GO:0010212]; sperm DNA condensation [GO:0035092]; spermatid development [GO:0007286]; triglyceride biosynthetic process [GO:0019432]	chromatin binding [GO:0003682]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; histone H2A acetyltransferase activity [GO:0043998]; histone H2AK5 acetyltransferase activity [GO:0043999]; histone H4K16 acetyltransferase activity [GO:0046972]; peptide 2-hydroxyisobutyryltransferase activity [GO:0106226]; peptide butyryltransferase activity [GO:0140065]; peptide crotonyltransferase activity [GO:0140064]; peptide lactyltransferase (CoA-dependent) activity [GO:0120300]; phospholipase binding [GO:0043274]; protein-containing complex binding [GO:0044877]; protein-lysine-acetyltransferase activity [GO:0061733]; transcription coactivator activity [GO:0003713]	chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic spindle pole [GO:0097431]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; piccolo histone acetyltransferase complex [GO:0032777]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]; Swr1 complex [GO:0000812]; transcription regulator complex [GO:0005667]	GO:0000122; GO:0000132; GO:0000724; GO:0000729; GO:0000776; GO:0000785; GO:0000786; GO:0000812; GO:0003682; GO:0003713; GO:0004402; GO:0005634; GO:0005654; GO:0005667; GO:0005694; GO:0005730; GO:0005737; GO:0005829; GO:0006289; GO:0006302; GO:0006303; GO:0006357; GO:0006473; GO:0006646; GO:0006656; GO:0006915; GO:0006974; GO:0007286; GO:0010212; GO:0010508; GO:0010867; GO:0018394; GO:0019432; GO:0021915; GO:0022008; GO:0030330; GO:0032703; GO:0032777; GO:0032991; GO:0035092; GO:0035267; GO:0035861; GO:0035973; GO:0042149; GO:0042753; GO:0042981; GO:0043161; GO:0043274; GO:0043998; GO:0043999; GO:0044877; GO:0045089; GO:0045591; GO:0045662; GO:0045663; GO:0045892; GO:0045893; GO:0045944; GO:0046972; GO:0048471; GO:0051315; GO:0051726; GO:0061733; GO:0062033; GO:0071211; GO:0071333; GO:0071392; GO:0097431; GO:0106226; GO:0120300; GO:0140064; GO:0140065; GO:0140297; GO:0140694; GO:0140861; GO:0140896; GO:1901798; GO:1901985; GO:1902036; GO:1902275; GO:1902425; GO:1905168; GO:1905337; GO:1905691; GO:1990166; GO:2000042; GO:2000779
GN017787	GN017787.1	Q2T9S3	62.5	315	301	316	6.47e-137	392	RPC6_BOVIN	DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F)	Bos taurus (Bovine)	positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; transcription by RNA polymerase III [GO:0006383]	double-stranded DNA binding [GO:0003690]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]	GO:0003690; GO:0005634; GO:0005654; GO:0005666; GO:0005737; GO:0006383; GO:0032728; GO:0045089
GN017788	GN017788.1	Q8N413	40.2	291	298	288	3.09e-64	206	S2545_HUMAN	Methylated amino-acid transporter SLC25A45 (Solute carrier family 25 member 45)	Homo sapiens (Human)	carnitine biosynthetic process [GO:0045329]	dimethylarginine transmembrane transporter activity [GO:7770027]; N(6),N(6),N(6)-trimethyl-L-lysine transmembrane transporter activity [GO:7770026]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0045329; GO:7770026; GO:7770027
GN017789	GN017789.1	Q4LE39	45.9	407	1556	1312	1.59e-75	280	ARI4B_HUMAN	AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1)	Homo sapiens (Human)	negative regulation of cell migration [GO:0030336]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; transcription cis-regulatory region binding [GO:0000976]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3-type complex [GO:0070822]	GO:0000122; GO:0000976; GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006357; GO:0030336; GO:0030512; GO:0070822; GO:1902455; GO:1902459
GN017790	GN017790.1	P42696	47.3	186	471	430	1.31e-46	170	RBM34_HUMAN	RNA-binding protein 34 (RNA-binding motif protein 34)	Homo sapiens (Human)	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]	RNA binding [GO:0003723]	nucleolus [GO:0005730]	GO:0000463; GO:0003723; GO:0005730
GN017791	GN017791.1	Q8C015	45.8	690	628	719	2.99e-150	454	PAK5_MOUSE	Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7)	Mus musculus (Mouse)	apoptotic process [GO:0006915]; cellular response to starvation [GO:0009267]; cytoskeleton organization [GO:0007010]; learning [GO:0007612]; locomotory behavior [GO:0007626]; memory [GO:0007613]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; regulation of MAPK cascade [GO:0043408]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; synapse [GO:0045202]	GO:0004674; GO:0005524; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0006915; GO:0007010; GO:0007612; GO:0007613; GO:0007626; GO:0009267; GO:0031965; GO:0043408; GO:0045202; GO:0106310; GO:2001237
GN017794	GN017794.1	Q575S9	27.8	97	177	179	9.68e-09	55.5	CYGB2_ORYLA	Cytoglobin-2 (Nitric oxygen dioxygenase CYGB) (EC 1.14.12.-) (Nitrite reductase CYGB) (EC 1.7.-.-) (Pseudoperoxidase CYGB) (EC 1.11.1.-) (Superoxide dismutase CYGB) (EC 1.15.1.1)	Oryzias latipes (Japanese rice fish) (Japanese killifish)	nitric oxide catabolic process [GO:0046210]; oxygen transport [GO:0015671]; removal of superoxide radicals [GO:0019430]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; nitric oxide dioxygenase activity, heme protein as donor [GO:0141118]; nitrite reductase activity [GO:0098809]; oxidoreductase activity [GO:0016491]; oxygen binding [GO:0019825]; superoxide dismutase activity [GO:0004784]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004784; GO:0005506; GO:0005634; GO:0005737; GO:0015671; GO:0016491; GO:0019430; GO:0019825; GO:0020037; GO:0046210; GO:0098809; GO:0141118
GN017796	GN017796.1	P36404	88.0	184	184	184	1.23e-117	333	ARL2_HUMAN	ADP-ribosylation factor-like protein 2	Homo sapiens (Human)	bicellular tight junction assembly [GO:0070830]; centrosome cycle [GO:0007098]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of GTPase activity [GO:0034260]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of microtubule polymerization [GO:0031116]; protein folding [GO:0006457]; regulation of aerobic respiration [GO:1903715]; regulation of glycolytic process [GO:0006110]; regulation of microtubule polymerization [GO:0031113]	GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; microtubule cytoskeleton [GO:0015630]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003924; GO:0005525; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005739; GO:0005758; GO:0005759; GO:0005813; GO:0005829; GO:0006110; GO:0006457; GO:0007098; GO:0010811; GO:0015630; GO:0016328; GO:0019003; GO:0031113; GO:0031116; GO:0034260; GO:0051457; GO:0070830; GO:1903715
GN017797	GN017797.1	P54366	89.4	66	286	415	3.53e-28	115	GSC_DROME	Homeobox protein goosecoid	Drosophila melanogaster (Fruit fly)	negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0001227; GO:0005634; GO:0006357; GO:0042803; GO:0045892; GO:0046982
GN017798	GN017798.1	P27867	55.2	330	370	357	2.52e-135	393	DHSO_RAT	Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9)	Rattus norvegicus (Rat)	D-glucuronate catabolic process to D-xylulose 5-phosphate [GO:0019640]; D-sorbitol catabolic process [GO:0006062]; D-sorbitol metabolic process [GO:0006060]; flagellated sperm motility [GO:0030317]; fructose biosynthetic process [GO:0046370]; response to cadmium ion [GO:0046686]; response to copper ion [GO:0046688]; response to hormone [GO:0009725]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; xylitol catabolic process [GO:0051160]; xylitol metabolic process [GO:0051164]	(R,R)-butanediol dehydrogenase activity [GO:0000721]; D-xylulose reductase activity [GO:0046526]; identical protein binding [GO:0042802]; L-iditol 2-dehydrogenase (NAD+) activity [GO:0003939]; NAD binding [GO:0051287]; ribitol 2-dehydrogenase (NAD+) activity [GO:0050255]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]	GO:0000721; GO:0003939; GO:0005739; GO:0005829; GO:0006060; GO:0006062; GO:0008270; GO:0009410; GO:0009725; GO:0016020; GO:0019640; GO:0030317; GO:0031514; GO:0031667; GO:0031966; GO:0042802; GO:0046370; GO:0046526; GO:0046686; GO:0046688; GO:0050255; GO:0051160; GO:0051164; GO:0051287; GO:0070062
GN017807	GN017807.1	Q6QQT1	30.9	330	335	302	1.20e-39	144	S39A1_TAKRU	Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zrt- and Irt-like protein 1) (ZIP-1)	Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)	zinc ion transmembrane transport [GO:0071577]	zinc ion transmembrane transporter activity [GO:0005385]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0005385; GO:0005789; GO:0005886; GO:0071577
GN017809	GN017809.1	Q8IV45	24.1	399	482	518	5.29e-21	99.4	UN5CL_HUMAN	UNC5C-like protein (Protein unc-5 homolog C-like) (ZU5 and death domain-containing protein)	Homo sapiens (Human)	positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of JNK cascade [GO:0046330]	netrin receptor activity [GO:0005042]; peptidase activity [GO:0008233]	cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005042; GO:0005829; GO:0005886; GO:0008233; GO:0016020; GO:0043123; GO:0046330
GN017810	GN017810.1	Q148E1	49.6	113	120	192	5.04e-30	109	COA8_BOVIN	Cytochrome c oxidase assembly factor 8 (COA8) (Apoptogenic protein 1, mitochondrial) (APOP-1)	Bos taurus (Bovine)	intrinsic apoptotic signaling pathway [GO:0097193]; mitochondrial respiratory chain complex IV assembly [GO:0033617]; protein stabilization [GO:0050821]; response to reactive oxygen species [GO:0000302]		matrix side of mitochondrial inner membrane [GO:0099617]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0000302; GO:0005739; GO:0005743; GO:0033617; GO:0050821; GO:0097193; GO:0099617
GN017811	GN017811.1	Q66II5	52.0	327	326	348	2.31e-122	358	T3HPD_XENTR	Trans-L-3-hydroxyproline dehydratase (EC 4.2.1.77) (Trans-3-hydroxy-L-proline dehydratase)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		hydro-lyase activity [GO:0016836]; trans-L-3-hydroxyproline dehydratase activity [GO:0050346]		GO:0016836; GO:0050346
GN017812	GN017812.1	P54366	89.4	66	286	415	3.53e-28	115	GSC_DROME	Homeobox protein goosecoid	Drosophila melanogaster (Fruit fly)	negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0001227; GO:0005634; GO:0006357; GO:0042803; GO:0045892; GO:0046982
GN017813	GN017813.1	P27867	55.2	330	345	357	7.03e-136	393	DHSO_RAT	Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9)	Rattus norvegicus (Rat)	D-glucuronate catabolic process to D-xylulose 5-phosphate [GO:0019640]; D-sorbitol catabolic process [GO:0006062]; D-sorbitol metabolic process [GO:0006060]; flagellated sperm motility [GO:0030317]; fructose biosynthetic process [GO:0046370]; response to cadmium ion [GO:0046686]; response to copper ion [GO:0046688]; response to hormone [GO:0009725]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; xylitol catabolic process [GO:0051160]; xylitol metabolic process [GO:0051164]	(R,R)-butanediol dehydrogenase activity [GO:0000721]; D-xylulose reductase activity [GO:0046526]; identical protein binding [GO:0042802]; L-iditol 2-dehydrogenase (NAD+) activity [GO:0003939]; NAD binding [GO:0051287]; ribitol 2-dehydrogenase (NAD+) activity [GO:0050255]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]	GO:0000721; GO:0003939; GO:0005739; GO:0005829; GO:0006060; GO:0006062; GO:0008270; GO:0009410; GO:0009725; GO:0016020; GO:0019640; GO:0030317; GO:0031514; GO:0031667; GO:0031966; GO:0042802; GO:0046370; GO:0046526; GO:0046686; GO:0046688; GO:0050255; GO:0051160; GO:0051164; GO:0051287; GO:0070062
GN017815	GN017815.1	Q5ZIJ9	27.3	216	713	954	2.26e-09	64.7	MIB2_CHICK	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (RING-type E3 ubiquitin transferase MIB2)	Gallus gallus (Chicken)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN017816	GN017816.1	Q9VUX2	25.2	210	412	1226	6.12e-10	65.1	MIB_DROME	E3 ubiquitin-protein ligase mind-bomb (EC 2.3.2.27) (Mind bomb homolog) (D-mib) (Protein mind bob 1) (RING-type E3 ubiquitin transferase mind-bomb)	Drosophila melanogaster (Fruit fly)	endocytosis [GO:0006897]; intracellular protein localization [GO:0008104]; lateral inhibition [GO:0046331]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; positive regulation of Notch signaling pathway [GO:0045747]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]; sensory organ development [GO:0007423]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	apical cortex [GO:0045179]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0000209; GO:0004842; GO:0005737; GO:0005829; GO:0006897; GO:0007219; GO:0007423; GO:0008104; GO:0008270; GO:0008593; GO:0016567; GO:0045179; GO:0045747; GO:0045807; GO:0046331; GO:0061630
GN017817	GN017817.1	Q9VUX2	25.2	210	384	1226	5.01e-10	65.1	MIB_DROME	E3 ubiquitin-protein ligase mind-bomb (EC 2.3.2.27) (Mind bomb homolog) (D-mib) (Protein mind bob 1) (RING-type E3 ubiquitin transferase mind-bomb)	Drosophila melanogaster (Fruit fly)	endocytosis [GO:0006897]; intracellular protein localization [GO:0008104]; lateral inhibition [GO:0046331]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; positive regulation of Notch signaling pathway [GO:0045747]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]; sensory organ development [GO:0007423]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	apical cortex [GO:0045179]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0000209; GO:0004842; GO:0005737; GO:0005829; GO:0006897; GO:0007219; GO:0007423; GO:0008104; GO:0008270; GO:0008593; GO:0016567; GO:0045179; GO:0045747; GO:0045807; GO:0046331; GO:0061630
GN017821	GN017821.1	Q91765	52.2	297	421	434	2.43e-77	249	FXA2A_XENLA	Forkhead box protein A2-A (FoxA2-A) (FoxA2a) (Fork head domain-related protein 3) (xFD-3) (Hepatocyte nuclear factor 3-beta homolog A) (HNF-3-beta-A) (HNF3-beta homolog A) (HNF3-beta-A) (xHNF3-beta-A) (xbeta-1)	Xenopus laevis (African clawed frog)	anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; mesoderm formation [GO:0001707]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001707; GO:0005634; GO:0006357; GO:0009653; GO:0019904; GO:0030154; GO:0043565; GO:0045893
GN017822	GN017822.1	Q8TD10	27.6	337	695	442	2.55e-23	107	MIPO1_HUMAN	Mirror-image polydactyly gene 1 protein	Homo sapiens (Human)		identical protein binding [GO:0042802]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0042802
GN017825	GN017825.1	A0A345BJN8	25.3	233	790	919	3.43e-09	64.3	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN017827	GN017827.1	Q642T7	53.5	516	751	765	7.09e-187	554	UTP25_XENTR	U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor homolog) (UTP25 small subunit processor component)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	embryonic organ development [GO:0048568]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; protein catabolic process [GO:0030163]; protein destabilization [GO:0031648]; protein localization to nucleolus [GO:1902570]	rRNA binding [GO:0019843]; U3 snoRNA binding [GO:0034511]	nucleolus [GO:0005730]; small-subunit processome [GO:0032040]	GO:0000462; GO:0005730; GO:0019843; GO:0030163; GO:0031648; GO:0032040; GO:0034511; GO:0048568; GO:1902570
GN017828	GN017828.1	Q6IQ97	54.8	73	273	419	4.40e-21	95.1	RBM41_DANRE	RNA-binding protein 4.1 (RNA-binding motif protein 4.1)	Danio rerio (Zebrafish) (Brachydanio rerio)	circadian rhythm [GO:0007623]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]	GO:0000381; GO:0003723; GO:0005634; GO:0007623; GO:0008270
GN017829	GN017829.1	Q9CW42	36.9	290	319	340	8.54e-62	202	MARC1_MOUSE	Mitochondrial amidoxime-reducing component 1 (mARC1) (EC 1.7.-.-) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 1) (MOSC domain-containing protein 1) (Moco sulfurase C-terminal domain-containing protein 1)	Mus musculus (Mouse)	cellular detoxification of nitrogen compound [GO:0070458]; nitrate metabolic process [GO:0042126]; nitric oxide biosynthetic process [GO:0006809]	molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940]; nitrite reductase (NO-forming) activity [GO:0050421]; nitrite reductase activity [GO:0098809]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; pyridoxal phosphate binding [GO:0030170]	membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nitric-oxide synthase complex [GO:1903958]	GO:0005739; GO:0005741; GO:0005743; GO:0006809; GO:0008940; GO:0016020; GO:0016661; GO:0030151; GO:0030170; GO:0042126; GO:0043546; GO:0050421; GO:0070458; GO:0098809; GO:1903958
GN017831	GN017831.1	Q9Y253	51.9	470	753	713	2.89e-150	458	POLH_HUMAN	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein)	Homo sapiens (Human)	DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; error-free translesion synthesis [GO:0070987]; regulation of DNA repair [GO:0006282]; response to UV-C [GO:0010225]; translesion synthesis [GO:0019985]	damaged DNA binding [GO:0003684]; DNA polymerase activity [GO:0034061]; DNA-directed DNA polymerase activity [GO:0003887]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]	GO:0000731; GO:0003684; GO:0003887; GO:0005634; GO:0005654; GO:0005657; GO:0006281; GO:0006282; GO:0010225; GO:0019985; GO:0034061; GO:0035861; GO:0070987
GN017837	GN017837.1	Q6INV3	74.2	225	272	238	5.33e-42	147	LRC57_XENLA	Leucine-rich repeat-containing protein 57	Xenopus laevis (African clawed frog)			cytoplasm [GO:0005737]	GO:0005737
GN017838	GN017838.1	Q9CRB6	42.0	174	178	176	2.00e-21	89.0	TPPP3_MOUSE	Tubulin polymerization-promoting protein family member 3	Mus musculus (Mouse)	decidualization [GO:0046697]; embryo implantation [GO:0007566]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; positive regulation of protein polymerization [GO:0032273]	tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; microtubule bundle [GO:0097427]; perinuclear region of cytoplasm [GO:0048471]	GO:0001578; GO:0005737; GO:0007566; GO:0015631; GO:0032273; GO:0046697; GO:0046785; GO:0048471; GO:0097427
GN017839	GN017839.1	Q20930	28.9	284	309	509	1.83e-26	112	MIG17_CAEEL	Metalloprotease mig-17 (EC 3.4.24.-) (Abnormal cell migration protein 17)	Caenorhabditis elegans	gonad morphogenesis [GO:0035262]; intracellular protein localization [GO:0008104]; protein autoprocessing [GO:0016540]; regulation of cell migration [GO:0030334]; regulation of distal tip cell migration [GO:1903354]; zymogen activation [GO:0031638]	metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]	basement membrane [GO:0005604]; extracellular region [GO:0005576]	GO:0004222; GO:0005576; GO:0005604; GO:0008104; GO:0008237; GO:0016540; GO:0030334; GO:0031638; GO:0035262; GO:1903354
GN017840	GN017840.1	Q9R013	54.7	300	732	462	2.96e-111	348	CATF_MOUSE	Cathepsin F (EC 3.4.22.41)	Mus musculus (Mouse)	immune system process [GO:0002376]; proteolysis [GO:0006508]	cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]	endoplasmic reticulum [GO:0005783]; intracellular organelle lumen [GO:0070013]; lysosome [GO:0005764]; plasma membrane [GO:0005886]	GO:0002376; GO:0004197; GO:0005764; GO:0005783; GO:0005886; GO:0006508; GO:0008234; GO:0070013
GN017844	GN017844.1	Q9H2Y7	31.3	195	2076	1883	3.63e-18	95.9	ZN106_HUMAN	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474)	Homo sapiens (Human)		RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]	GO:0003723; GO:0005730; GO:0016607
GN017845	GN017845.1	P49355	59.7	395	458	437	3.00e-176	503	FNTB_BOVIN	Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta)	Bos taurus (Bovine)	protein farnesylation [GO:0018343]	protein farnesyltransferase activity [GO:0004660]; zinc ion binding [GO:0008270]	protein farnesyltransferase complex [GO:0005965]	GO:0004660; GO:0005965; GO:0008270; GO:0018343
GN017846	GN017846.1	P52162	70.4	125	163	160	2.48e-48	156	MAX_CHICK	Protein max (Myc-associated factor X)	Gallus gallus (Chicken)	positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983]	MLL1 complex [GO:0071339]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0003700; GO:0045944; GO:0046983; GO:0071339; GO:0090575
GN017851	GN017851.1	O34371	23.8	366	433	428	1.48e-17	87.8	YTET_BACSU	Putative oxidoreductase YteT (EC 1.-.-.-)	Bacillus subtilis (strain 168)		nucleotide binding [GO:0000166]		GO:0000166
GN017853	GN017853.1	Q9WTY1	35.0	217	599	482	1.49e-16	86.3	PDCD7_MOUSE	Programmed cell death protein 7 (ES18)	Mus musculus (Mouse)	positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of T cell apoptotic process [GO:0070234]; response to glucocorticoid [GO:0051384]; RNA splicing [GO:0008380]		spliceosomal complex [GO:0005681]; U11/U12 snRNP [GO:0034693]; U12-type precatalytic spliceosome [GO:0071016]; U12-type spliceosomal complex [GO:0005689]; U2AF complex [GO:0089701]	GO:0005681; GO:0005689; GO:0008380; GO:0034693; GO:0051384; GO:0070234; GO:0071016; GO:0089701; GO:2001235
GN017854	GN017854.1	A0A2V5GVB6	26.6	353	572	567	4.95e-24	109	UNGD_ASPV1	Unguisins hydrolase ungD (EC 3.4.-.-) (Unguisins biosynthesis cluster protein D)	Aspergillus violaceofuscus (strain CBS 115571)				
GN017859	GN017859.1	Q68BL7	31.8	242	614	652	5.09e-26	116	OLM2A_HUMAN	Olfactomedin-like protein 2A (Photomedin-1)	Homo sapiens (Human)	signal transduction [GO:0007165]	extracellular matrix binding [GO:0050840]; identical protein binding [GO:0042802]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0007165; GO:0031012; GO:0042802; GO:0050840
GN017860	GN017860.1	Q90694	48.1	181	225	191	4.34e-49	162	CDC42_CHICK	Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)	Gallus gallus (Chicken)	actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell junction assembly [GO:0034329]; dendritic spine morphogenesis [GO:0060997]; embryonic heart tube development [GO:0035050]; endocytosis [GO:0006897]; endothelin receptor signaling pathway [GO:0086100]; establishment of cell polarity [GO:0030010]; establishment of epithelial cell apical/basal polarity [GO:0045198]; filopodium assembly [GO:0046847]; heart process [GO:0003015]; host-mediated perturbation of viral process [GO:0044788]; integrin-mediated signaling pathway [GO:0007229]; maintenance of protein location [GO:0045185]; negative regulation of protein-containing complex assembly [GO:0031333]; neuropilin signaling pathway [GO:0038189]; phagocytosis, engulfment [GO:0006911]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cytokinesis [GO:0032467]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of pinocytosis [GO:0048549]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of filopodium assembly [GO:0051489]; regulation of postsynapse organization [GO:0099175]; small GTPase-mediated signal transduction [GO:0007264]	apolipoprotein A-I receptor binding [GO:0034191]; G protein activity [GO:0003925]; GBD domain binding [GO:0032427]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996]; ubiquitin protein ligase activity [GO:0061630]	apical part of cell [GO:0045177]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; COG complex [GO:0017119]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; filopodium [GO:0030175]; glutamatergic synapse [GO:0098978]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; neuronal cell body [GO:0043025]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; spindle midzone [GO:0051233]; storage vacuole [GO:0000322]	GO:0000322; GO:0003015; GO:0003253; GO:0003924; GO:0003925; GO:0005525; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0005911; GO:0006897; GO:0006911; GO:0007015; GO:0007229; GO:0007264; GO:0010592; GO:0016020; GO:0017119; GO:0019901; GO:0030010; GO:0030036; GO:0030175; GO:0030307; GO:0030335; GO:0030425; GO:0030496; GO:0030742; GO:0031256; GO:0031274; GO:0031333; GO:0031996; GO:0032427; GO:0032467; GO:0034191; GO:0034329; GO:0035050; GO:0036464; GO:0038189; GO:0042802; GO:0042995; GO:0043025; GO:0044788; GO:0045177; GO:0045185; GO:0045198; GO:0045335; GO:0045860; GO:0046847; GO:0048549; GO:0051233; GO:0051489; GO:0051491; GO:0051496; GO:0051988; GO:0060501; GO:0060997; GO:0061630; GO:0072686; GO:0086100; GO:0098794; GO:0098978; GO:0099175; GO:1900026
GN017863	GN017863.1	Q5RD94	56.4	243	237	246	6.24e-85	255	MED6_PONAB	Mediator of RNA polymerase II transcription subunit 6 (Mediator complex subunit 6)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	regulation of transcription by RNA polymerase II [GO:0006357]	transcription coregulator activity [GO:0003712]	mediator complex [GO:0016592]	GO:0003712; GO:0006357; GO:0016592
GN017864	GN017864.1	Q8C1A3	42.5	737	728	696	2.21e-175	521	MTRR_MOUSE	Methionine synthase reductase (MSR) (EC 1.16.1.8) (Aquacobalamin reductase) (AqCbl reductase)	Mus musculus (Mouse)	cobalamin metabolic process [GO:0009235]; folic acid metabolic process [GO:0046655]; homocysteine metabolic process [GO:0050667]; L-homocysteine catabolic process [GO:0043418]; L-methionine biosynthetic process [GO:0071265]; L-methionine cycle [GO:0033353]; protein stabilization [GO:0050821]	[methionine synthase] reductase (NADPH) activity [GO:0030586]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; molecular carrier activity [GO:0140104]; NADPH binding [GO:0070402]; NADPH-hemoprotein reductase activity [GO:0003958]; oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor [GO:0016723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]	GO:0003958; GO:0005654; GO:0005737; GO:0005829; GO:0009235; GO:0010181; GO:0016723; GO:0030586; GO:0033353; GO:0043418; GO:0045111; GO:0046655; GO:0050660; GO:0050667; GO:0050821; GO:0070402; GO:0071265; GO:0071949; GO:0140104
GN017867	GN017867.1	Q5F4B8	26.1	417	448	464	5.42e-40	152	S46A3_CHICK	Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)	Gallus gallus (Chicken)	vacuolar transmembrane transport [GO:0034486]	transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]	GO:0005765; GO:0022857; GO:0034486
GN017868	GN017868.1	Q5RBM3	26.6	403	412	463	5.90e-36	140	S46A3_PONAB	Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; vacuolar transmembrane transport [GO:0034486]	copper ion transmembrane transporter activity [GO:0005375]	lysosomal membrane [GO:0005765]	GO:0005375; GO:0005765; GO:0034486; GO:1904613
GN017872	GN017872.1	Q5F4B8	25.5	416	448	464	1.91e-38	148	S46A3_CHICK	Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)	Gallus gallus (Chicken)	vacuolar transmembrane transport [GO:0034486]	transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]	GO:0005765; GO:0022857; GO:0034486
GN017873	GN017873.1	Q5RBM3	26.3	403	412	463	4.46e-37	143	S46A3_PONAB	Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; vacuolar transmembrane transport [GO:0034486]	copper ion transmembrane transporter activity [GO:0005375]	lysosomal membrane [GO:0005765]	GO:0005375; GO:0005765; GO:0034486; GO:1904613
GN017875	GN017875.1	Q14527	38.7	1297	1322	1009	3.72e-276	812	HLTF_HUMAN	DNA-dependent ATPase/E3 ubiquitin-protein ligase HLTF (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (Helicase-like transcription factor) (HLTF) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (SMARCA3) (Sucrose nonfermenting protein 2-like 3)	Homo sapiens (Human)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; DNA damage response [GO:0006974]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein K63-linked ubiquitination [GO:0070534]; protein localization to chromatin [GO:0071168]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of neurogenesis [GO:0050767]; replication fork reversal [GO:0071932]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA translocase activity [GO:0015616]; G-quadruplex unwinding activity [GO:0160225]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000209; GO:0000785; GO:0003697; GO:0003723; GO:0005524; GO:0005654; GO:0005694; GO:0005886; GO:0006974; GO:0008094; GO:0008270; GO:0015616; GO:0016020; GO:0016363; GO:0016567; GO:0016887; GO:0031625; GO:0042789; GO:0043596; GO:0045944; GO:0050767; GO:0061630; GO:0062072; GO:0070534; GO:0071168; GO:0071932; GO:0090575; GO:0140234; GO:0140658; GO:0141119; GO:0160225
GN017876	GN017876.1	Q6PCN7	31.8	977	1082	1003	1.67e-138	446	HLTF_MOUSE	DNA-dependent ATPase/E3 ubiquitin-protein ligase HLTF (EC 2.3.2.27) (EC 3.6.4.-) (Helicase-like transcription factor) (HLTF) (P113) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) (TNF-response element-binding protein)	Mus musculus (Mouse)	chromosomal DNA methylation maintenance following DNA replication [GO:0141119]; DNA damage response [GO:0006974]; mRNA transcription by RNA polymerase II [GO:0042789]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein K63-linked ubiquitination [GO:0070534]; protein localization to chromatin [GO:0071168]; protein polyubiquitination [GO:0000209]; regulation of neurogenesis [GO:0050767]; replication fork reversal [GO:0071932]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent chromatin remodeler activity [GO:0140658]; DNA translocase activity [GO:0015616]; G-quadruplex unwinding activity [GO:0160225]; histone H3K23 ubiquitin ligase activity [GO:0140234]; histone H3K9me2/3 reader activity [GO:0062072]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; nuclear matrix [GO:0016363]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0000209; GO:0000785; GO:0003697; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0006974; GO:0008094; GO:0008270; GO:0015616; GO:0016363; GO:0016887; GO:0031625; GO:0042789; GO:0043596; GO:0045944; GO:0050767; GO:0061630; GO:0062072; GO:0070534; GO:0071168; GO:0071932; GO:0090575; GO:0140234; GO:0140658; GO:0141119; GO:0160225
GN017877	GN017877.1	Q5F4B8	25.1	410	457	464	2.03e-36	142	S46A3_CHICK	Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (Solute carrier family 46 member 3)	Gallus gallus (Chicken)	vacuolar transmembrane transport [GO:0034486]	transmembrane transporter activity [GO:0022857]	lysosomal membrane [GO:0005765]	GO:0005765; GO:0022857; GO:0034486
GN017879	GN017879.1	P23050	55.8	77	337	322	4.14e-16	81.3	FOS_AVINK	p55-v-Fos-transforming protein	Avian retrovirus NK24	regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]	host cell nucleus [GO:0042025]	GO:0003677; GO:0003700; GO:0006357; GO:0042025
GN017880	GN017880.1	Q17296	27.4	186	393	378	1.35e-13	75.1	OPSD_CATBO	Rhodopsin	Cataglyphis bombycina (Saharan silver ant) (Formica bombycina)	phototransduction [GO:0007602]; visual perception [GO:0007601]	G protein-coupled receptor activity [GO:0004930]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007601; GO:0007602
GN017881	GN017881.1	P19073	60.1	193	202	191	1.84e-79	238	CDC42_YEAST	Cell division control protein 42 (EC 3.6.5.2) (Suppressor of RHO3 protein 2)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	actin filament organization [GO:0007015]; budding cell apical bud growth [GO:0007118]; budding cell isotropic bud growth [GO:0007119]; conjugation with cellular fusion [GO:0000747]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010]; invasive growth in response to glucose limitation [GO:0001403]; nuclear membrane organization [GO:0071763]; positive regulation of exocytosis [GO:0045921]; positive regulation of pseudohyphal growth [GO:2000222]; regulation of cell morphogenesis [GO:0022604]; regulation of exit from mitosis [GO:0007096]; regulation of exocyst localization [GO:0060178]; regulation of vacuole fusion, non-autophagic [GO:0032889]; Rho protein signal transduction [GO:0007266]; septin ring organization [GO:0031106]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]	cell periphery [GO:0071944]; cellular bud neck [GO:0005935]; cellular bud tip [GO:0005934]; fungal-type vacuole membrane [GO:0000329]; incipient cellular bud site [GO:0000131]; mating projection tip [GO:0043332]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; septin ring [GO:0005940]	GO:0000131; GO:0000329; GO:0000747; GO:0001403; GO:0003924; GO:0003925; GO:0005525; GO:0005635; GO:0005886; GO:0005934; GO:0005935; GO:0005940; GO:0006897; GO:0007015; GO:0007096; GO:0007118; GO:0007119; GO:0007266; GO:0019901; GO:0022604; GO:0030010; GO:0031106; GO:0031965; GO:0032889; GO:0043332; GO:0045921; GO:0060178; GO:0071763; GO:0071944; GO:2000222
GN017883	GN017883.1	Q6P9Z4	25.0	416	628	617	7.24e-20	97.4	FEM1A_DANRE	Protein fem-1 homolog A (FEM1a) (FEM1-alpha)	Danio rerio (Zebrafish) (Brachydanio rerio)	negative regulation of inflammatory response [GO:0050728]; positive regulation of inflammatory response [GO:0050729]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005737; GO:0005739; GO:0016567; GO:0031462; GO:0043161; GO:0050728; GO:0050729; GO:0140627; GO:1990756
GN017888	GN017888.1	Q3T030	86.4	420	418	418	1.24e-252	694	PRS6B_BOVIN	26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (Proteasome 26S subunit ATPase 4)	Bos taurus (Bovine)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; proteasome-activating activity [GO:0036402]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]	GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0016887; GO:0022624; GO:0036402
GN017889	GN017889.1	Q4R6I5	30.1	594	631	586	2.61e-76	257	CLHC1_MACFA	Clathrin heavy chain linker domain-containing protein 1	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)				
GN017890	GN017890.1	Q9HF56	41.4	198	228	191	1.92e-48	160	CDC42_EREGS	Cell division control protein 42 (EC 3.6.5.2)	Eremothecium gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Ashbya gossypii)	actin filament organization [GO:0007015]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; protein kinase binding [GO:0019901]	cell cortex [GO:0005938]; cell tip [GO:0051286]; endomembrane system [GO:0012505]; plasma membrane [GO:0005886]; site of polarized growth [GO:0030427]	GO:0003925; GO:0005525; GO:0005886; GO:0005938; GO:0006897; GO:0007015; GO:0007264; GO:0012505; GO:0019901; GO:0030010; GO:0030427; GO:0051286
GN017892	GN017892.1	D3ZU57	42.7	82	83	597	1.94e-14	69.7	RIOX1_RAT	Ribosomal oxygenase 1 (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Histone lysine demethylase NO66)	Rattus norvegicus (Rat)	negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; regulation of DNA repair [GO:0006282]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; iron ion binding [GO:0005506]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein demethylase activity [GO:0140457]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005506; GO:0005634; GO:0005654; GO:0005730; GO:0006282; GO:0016706; GO:0032453; GO:0034647; GO:0036139; GO:0045668; GO:0045892; GO:0051864; GO:0140457; GO:0140680
GN017894	GN017894.1	O16327	35.4	175	256	212	2.56e-30	115	IRG1_CAEEL	Protein irg-1 (Infection response protein 1)	Caenorhabditis elegans	antibacterial innate immune response [GO:0140367]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]			GO:0045087; GO:0050829; GO:0140367
GN017896	GN017896.1	C3XRY1	50.2	267	295	607	5.23e-93	290	NO66_BRAFL	Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 (EC 1.14.11.-) (EC 1.14.11.27) (Histone lysine demethylase NO66)	Branchiostoma floridae (Florida lancelet) (Amphioxus)	negative regulation of DNA-templated transcription [GO:0045892]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; histone H3K36 demethylase activity [GO:0051864]; histone H3K36me/H3K36me2 demethylase activity [GO:0140680]; histone H3K4 demethylase activity [GO:0032453]; histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO:0034647]; iron ion binding [GO:0005506]; peptidyl-histidine dioxygenase activity [GO:0036139]	nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005506; GO:0005634; GO:0005730; GO:0016706; GO:0032453; GO:0034647; GO:0036139; GO:0045892; GO:0051864; GO:0140680
GN017897	GN017897.1	Q9QZ05	45.5	134	230	1648	2.37e-30	121	E2AK4_MOUSE	eIF-2-alpha kinase GCN2 (Eukaryotic translation initiation factor 2-alpha kinase 4) (EC 2.7.11.1) (GCN2-like protein) (mGCN2)	Mus musculus (Mouse)	cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to starvation [GO:0009267]; cellular response to UV [GO:0034644]; DNA damage checkpoint signaling [GO:0000077]; endoplasmic reticulum unfolded protein response [GO:0030968]; GCN2-mediated signaling [GO:0140469]; host-mediated suppression of viral genome replication [GO:0044828]; learning [GO:0007612]; long-term memory [GO:0007616]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of translational initiation in response to stress [GO:0032057]; neuron projection extension [GO:1990138]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translational initiation in response to starvation [GO:0071264]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cytoplasmic translational initiation in response to stress [GO:1990611]; regulation of feeding behavior [GO:0060259]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; regulation of translational initiation in response to stress [GO:0043558]; response to amino acid starvation [GO:1990928]; response to endoplasmic reticulum stress [GO:0034976]; T cell activation involved in immune response [GO:0002286]; translational initiation [GO:0006413]; viral translation [GO:0019081]	ATP binding [GO:0005524]; eukaryotic initiation factor eIF2 binding [GO:0071074]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic ribosome [GO:0022626]; nucleus [GO:0005634]	GO:0000049; GO:0000077; GO:0001934; GO:0002230; GO:0002286; GO:0002821; GO:0004672; GO:0004674; GO:0004694; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006413; GO:0006446; GO:0006468; GO:0007612; GO:0007616; GO:0009267; GO:0010628; GO:0010998; GO:0017148; GO:0019081; GO:0022626; GO:0030968; GO:0032057; GO:0034198; GO:0034644; GO:0034976; GO:0043558; GO:0044828; GO:0045665; GO:0045947; GO:0046777; GO:0060259; GO:0070417; GO:0071074; GO:0071264; GO:0106310; GO:0140469; GO:1900273; GO:1990138; GO:1990611; GO:1990928
GN017898	GN017898.1	Q60954	64.6	410	492	390	1.76e-147	430	MEIS1_MOUSE	Homeobox protein Meis1 (Myeloid ecotropic viral integration site 1)	Mus musculus (Mouse)	angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; cell growth involved in cardiac muscle cell development [GO:0061049]; definitive hemopoiesis [GO:0060216]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; hemopoiesis [GO:0030097]; lens morphogenesis in camera-type eye [GO:0002089]; locomotory behavior [GO:0007626]; megakaryocyte development [GO:0035855]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000978; GO:0000981; GO:0001228; GO:0001525; GO:0001654; GO:0002089; GO:0003677; GO:0003682; GO:0005634; GO:0005654; GO:0005667; GO:0006355; GO:0006357; GO:0007420; GO:0007626; GO:0008284; GO:0009880; GO:0009887; GO:0030097; GO:0035855; GO:0043565; GO:0045638; GO:0045665; GO:0045944; GO:0048514; GO:0060216; GO:0061049
GN017901	GN017901.1	P62205	43.3	603	644	598	2.03e-167	494	PLK1_XENTR	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Plx1) (Polo-like kinase 1) (PLK-1)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mitotic cell cycle [GO:0000278]; mitotic cleavage furrow formation [GO:1903673]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic spindle organization [GO:0007052]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein localization to chromatin [GO:0071168]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle pole [GO:0000922]	GO:0000278; GO:0000776; GO:0000922; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0007052; GO:0007095; GO:0030496; GO:0071168; GO:0106310; GO:1903673; GO:2000042
GN017906	GN017906.1	Q9P2E2	34.9	370	699	1029	3.96e-51	195	KIF17_HUMAN	Kinesin-like protein KIF17 (KIF3-related motor protein)	Homo sapiens (Human)	anterograde dendritic transport of neurotransmitter receptor complex [GO:0098971]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; plus-end-directed microtubule motor activity [GO:0008574]	cilium [GO:0005929]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; kinesin complex [GO:0005871]; microtubule organizing center [GO:0005815]; neuron projection [GO:0043005]	GO:0005524; GO:0005815; GO:0005829; GO:0005871; GO:0005929; GO:0008017; GO:0008574; GO:0032839; GO:0043005; GO:0098971
GN017908	GN017908.1	A5YVV0	28.1	594	638	661	3.11e-52	194	LAC3_ANOGA	Multicopper oxidase 3 (AgMCO3) (EC 1.10.3.2) (Laccase-3)	Anopheles gambiae (African malaria mosquito)		copper ion binding [GO:0005507]; hydroquinone:oxygen oxidoreductase activity [GO:0052716]	extracellular region [GO:0005576]	GO:0005507; GO:0005576; GO:0052716
GN017909	GN017909.1	Q17031	40.6	175	189	191	3.91e-43	145	CDC42_ANOGA	Cdc42 homolog (EC 3.6.5.2) (25 kDa GTP-binding protein)	Anopheles gambiae (African malaria mosquito)	actin filament organization [GO:0007015]; ameboidal-type cell migration [GO:0001667]; anatomical structure morphogenesis [GO:0009653]; cellular process involved in reproduction in multicellular organism [GO:0022412]; developmental process involved in reproduction [GO:0003006]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010]; hemocyte migration [GO:0035099]; melanization defense response [GO:0035006]; positive regulation of cellular component organization [GO:0051130]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; protein kinase binding [GO:0019901]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0001667; GO:0003006; GO:0003925; GO:0005525; GO:0005737; GO:0005886; GO:0005912; GO:0006897; GO:0007015; GO:0007264; GO:0009653; GO:0019901; GO:0022412; GO:0030010; GO:0035006; GO:0035099; GO:0051130
GN017910	GN017910.1	Q16YG0	37.1	175	185	191	7.17e-28	106	CDC42_AEDAE	Cdc42 homolog (EC 3.6.5.2)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	ameboidal-type cell migration [GO:0001667]; anatomical structure morphogenesis [GO:0009653]; cellular process involved in reproduction in multicellular organism [GO:0022412]; developmental process involved in reproduction [GO:0003006]; hemocyte migration [GO:0035099]; maintenance of protein location [GO:0045185]; melanization defense response [GO:0035006]; positive regulation of cellular component organization [GO:0051130]; positive regulation of protein kinase activity [GO:0045860]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0001667; GO:0003006; GO:0003925; GO:0005525; GO:0005737; GO:0005886; GO:0005912; GO:0007264; GO:0009653; GO:0022412; GO:0035006; GO:0035099; GO:0045185; GO:0045860; GO:0051130
GN017911	GN017911.1	Q17031	36.8	190	185	191	2.06e-30	112	CDC42_ANOGA	Cdc42 homolog (EC 3.6.5.2) (25 kDa GTP-binding protein)	Anopheles gambiae (African malaria mosquito)	actin filament organization [GO:0007015]; ameboidal-type cell migration [GO:0001667]; anatomical structure morphogenesis [GO:0009653]; cellular process involved in reproduction in multicellular organism [GO:0022412]; developmental process involved in reproduction [GO:0003006]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010]; hemocyte migration [GO:0035099]; melanization defense response [GO:0035006]; positive regulation of cellular component organization [GO:0051130]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; protein kinase binding [GO:0019901]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0001667; GO:0003006; GO:0003925; GO:0005525; GO:0005737; GO:0005886; GO:0005912; GO:0006897; GO:0007015; GO:0007264; GO:0009653; GO:0019901; GO:0022412; GO:0030010; GO:0035006; GO:0035099; GO:0051130
GN017912	GN017912.1	P17081	35.8	190	185	205	2.66e-31	115	RHOQ_HUMAN	Rho-related GTP-binding protein RhoQ (EC 3.6.5.2) (Ras-like protein TC10) (Ras-like protein family member 7A)	Homo sapiens (Human)	actin filament organization [GO:0007015]; cellular response to insulin stimulus [GO:0032869]; cortical actin cytoskeleton organization [GO:0030866]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010]; GTP metabolic process [GO:0046039]; insulin receptor signaling pathway [GO:0008286]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of D-glucose import across plasma membrane [GO:0046326]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin cytoskeleton organization [GO:0032956]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GBD domain binding [GO:0032427]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; profilin binding [GO:0005522]; protein kinase binding [GO:0019901]	actin filament [GO:0005884]; extracellular exosome [GO:0070062]; Golgi-associated vesicle membrane [GO:0030660]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005522; GO:0005525; GO:0005884; GO:0005886; GO:0006897; GO:0007015; GO:0007264; GO:0008286; GO:0019901; GO:0030010; GO:0030660; GO:0030866; GO:0032427; GO:0032869; GO:0032956; GO:0045121; GO:0045944; GO:0046039; GO:0046326; GO:0051491; GO:0070062; GO:1903077
GN017913	GN017913.1	P17081	36.3	171	185	205	1.34e-31	116	RHOQ_HUMAN	Rho-related GTP-binding protein RhoQ (EC 3.6.5.2) (Ras-like protein TC10) (Ras-like protein family member 7A)	Homo sapiens (Human)	actin filament organization [GO:0007015]; cellular response to insulin stimulus [GO:0032869]; cortical actin cytoskeleton organization [GO:0030866]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010]; GTP metabolic process [GO:0046039]; insulin receptor signaling pathway [GO:0008286]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of D-glucose import across plasma membrane [GO:0046326]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of actin cytoskeleton organization [GO:0032956]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GBD domain binding [GO:0032427]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; profilin binding [GO:0005522]; protein kinase binding [GO:0019901]	actin filament [GO:0005884]; extracellular exosome [GO:0070062]; Golgi-associated vesicle membrane [GO:0030660]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005522; GO:0005525; GO:0005884; GO:0005886; GO:0006897; GO:0007015; GO:0007264; GO:0008286; GO:0019901; GO:0030010; GO:0030660; GO:0030866; GO:0032427; GO:0032869; GO:0032956; GO:0045121; GO:0045944; GO:0046039; GO:0046326; GO:0051491; GO:0070062; GO:1903077
GN017914	GN017914.1	P0CY33	33.9	189	192	191	5.45e-26	101	CDC42_CANAL	Cell division control protein 42 homolog (EC 3.6.5.2)	Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)	actin filament organization [GO:0007015]; budding cell apical bud growth [GO:0007118]; budding cell isotropic bud growth [GO:0007119]; cell budding [GO:0007114]; cell growth mode switching, budding to filamentous [GO:0036187]; cell morphogenesis [GO:0000902]; cell wall modification [GO:0042545]; conjugation with cellular fusion [GO:0000747]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010]; filamentous growth [GO:0030447]; filamentous growth of a population of unicellular organisms [GO:0044182]; filamentous growth of a population of unicellular organisms in response to biotic stimulus [GO:0036180]; hyphal growth [GO:0030448]; invasive growth in response to glucose limitation [GO:0001403]; positive regulation of exocytosis [GO:0045921]; positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus [GO:1900445]; positive regulation of pseudohyphal growth [GO:2000222]; regulation of cell growth [GO:0001558]; regulation of cell morphogenesis [GO:0022604]; regulation of exit from mitosis [GO:0007096]; regulation of exocyst localization [GO:0060178]; regulation of vacuole fusion, non-autophagic [GO:0032889]; Rho protein signal transduction [GO:0007266]; septin ring organization [GO:0031106]; septum digestion after cytokinesis [GO:0000920]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; protein kinase binding [GO:0019901]	cell septum [GO:0030428]; cellular bud neck [GO:0005935]; cellular bud tip [GO:0005934]; extracellular vesicle [GO:1903561]; fungal-type vacuole membrane [GO:0000329]; hyphal tip [GO:0001411]; hyphal tip polarisome [GO:0031562]; incipient cellular bud site [GO:0000131]; mating projection tip [GO:0043332]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; septin ring [GO:0005940]; spitzenkorper [GO:0031521]	GO:0000131; GO:0000329; GO:0000747; GO:0000902; GO:0000920; GO:0001403; GO:0001411; GO:0001558; GO:0003925; GO:0005525; GO:0005886; GO:0005934; GO:0005935; GO:0005940; GO:0006897; GO:0007015; GO:0007096; GO:0007114; GO:0007118; GO:0007119; GO:0007266; GO:0016020; GO:0019901; GO:0022604; GO:0030010; GO:0030428; GO:0030447; GO:0030448; GO:0031106; GO:0031521; GO:0031562; GO:0031965; GO:0032889; GO:0036180; GO:0036187; GO:0042545; GO:0043332; GO:0044182; GO:0045921; GO:0060178; GO:1900445; GO:1903561; GO:2000222
GN017915	GN017915.1	Q8R527	31.9	188	186	205	3.75e-28	107	RHOQ_MOUSE	Rho-related GTP-binding protein RhoQ (EC 3.6.5.2) (Ras-like protein TC10)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cellular response to insulin stimulus [GO:0032869]; cortical actin cytoskeleton organization [GO:0030866]; endocytosis [GO:0006897]; establishment of cell polarity [GO:0030010]; GTP metabolic process [GO:0046039]; insulin receptor signaling pathway [GO:0008286]; negative regulation of D-glucose import across plasma membrane [GO:0046325]; negative regulation of protein localization to plasma membrane [GO:1903077]; positive regulation of D-glucose import across plasma membrane [GO:0046326]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell shape [GO:0008360]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GBD domain binding [GO:0032427]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; profilin binding [GO:0005522]; protein kinase binding [GO:0019901]	actin filament [GO:0005884]; cytoplasm [GO:0005737]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005522; GO:0005525; GO:0005737; GO:0005884; GO:0005886; GO:0006897; GO:0007015; GO:0007264; GO:0008286; GO:0008360; GO:0019901; GO:0030010; GO:0030036; GO:0030866; GO:0032427; GO:0032869; GO:0045121; GO:0045944; GO:0046039; GO:0046325; GO:0046326; GO:0051491; GO:1903077
GN017916	GN017916.1	Q05062	41.1	192	198	191	4.69e-44	148	CDC42_CAEEL	Cell division control protein 42 homolog (EC 3.6.5.2) (CDC42Ce)	Caenorhabditis elegans	actin filament organization [GO:0007015]; endocytosis [GO:0006897]; epithelial tube morphogenesis [GO:0060562]; establishment of cell polarity [GO:0030010]; establishment of mitotic spindle localization [GO:0040001]; establishment of mitotic spindle orientation [GO:0000132]; establishment or maintenance of cell polarity [GO:0007163]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of nematode male tail tip morphogenesis [GO:0110039]; regulation of actin filament-based process [GO:0032970]; regulation of Golgi organization [GO:1903358]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	GO:0000132; GO:0003924; GO:0003925; GO:0005525; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0005938; GO:0006897; GO:0007015; GO:0007163; GO:0007264; GO:0016020; GO:0019901; GO:0030010; GO:0032970; GO:0040001; GO:0048471; GO:0055037; GO:0060562; GO:0110039; GO:1903358; GO:2000370
GN017917	GN017917.1	Q9GPQ8	32.0	181	202	196	3.46e-28	107	RACL_DICDI	Rho-related protein racL (EC 3.6.5.2)	Dictyostelium discoideum (Social amoeba)	actin filament organization [GO:0007015]; establishment or maintenance of cell polarity [GO:0007163]; mating [GO:0007618]; mitotic cytokinesis [GO:0000281]; regulation of cell shape [GO:0008360]; response to light intensity [GO:0009642]; small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]	cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]	GO:0000281; GO:0003925; GO:0005525; GO:0005856; GO:0005886; GO:0007015; GO:0007163; GO:0007264; GO:0007618; GO:0008360; GO:0009642; GO:0031410
GN017918	GN017918.1	F1NZI4	33.8	693	936	702	9.86e-126	399	PGGHG_CHICK	Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107) (Acid trehalase-like protein 1)	Gallus gallus (Chicken)	carbohydrate metabolic process [GO:0005975]	protein-glucosylgalactosylhydroxylysine glucosidase activity [GO:0047402]	cytosol [GO:0005829]	GO:0005829; GO:0005975; GO:0047402
GN017919	GN017919.1	P14621	48.4	93	139	99	1.41e-23	90.9	ACYP2_HUMAN	Acylphosphatase-2 (EC 3.6.1.7) (Acylphosphatase, muscle type isozyme) (Acylphosphate phosphohydrolase 2)	Homo sapiens (Human)	phosphate-containing compound metabolic process [GO:0006796]	acylphosphatase activity [GO:0003998]; identical protein binding [GO:0042802]	mitochondrion [GO:0005739]	GO:0003998; GO:0005739; GO:0006796; GO:0042802
GN017920	GN017920.1	F1R2X6	44.8	1442	1410	1825	0.0	1195	PSM4B_DANRE	Proteasome activator complex subunit 4B (Proteasome activator PA200-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; sperm DNA condensation [GO:0035092]	peptidase activator activity [GO:0016504]; proteasome binding [GO:0070628]	cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spermatoproteasome complex [GO:1990111]	GO:0005634; GO:0005829; GO:0006281; GO:0006974; GO:0010499; GO:0016504; GO:0016607; GO:0035092; GO:0070628; GO:1990111
GN017921	GN017921.1	Q14697	54.6	914	935	944	0.0	1034	GANAB_HUMAN	Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; N-glycan processing [GO:0006491]	alpha-glucosidase activity [GO:0090599]; carbohydrate binding [GO:0030246]; Glc2Man9GlcNAc2 oligosaccharide glucosidase activity [GO:0106407]; glucan 1,3-alpha-glucosidase activity [GO:0033919]; RNA binding [GO:0003723]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; glucosidase II complex [GO:0017177]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]	GO:0003723; GO:0005783; GO:0005788; GO:0005794; GO:0005975; GO:0006491; GO:0016020; GO:0017177; GO:0030246; GO:0033919; GO:0042470; GO:0043231; GO:0070062; GO:0090599; GO:0106407
GN017922	GN017922.1	Q8K1J6	50.1	405	425	434	1.29e-130	386	TRNT1_MOUSE	CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase)	Mus musculus (Mouse)	mitochondrial tRNA 3'-end processing [GO:1990180]; rescue of stalled cytosolic ribosome [GO:0072344]; tRNA 3'-terminal CCA addition [GO:0001680]; tRNA processing [GO:0008033]; tRNA surveillance [GO:0106354]	CCA tRNA nucleotidyltransferase activity [GO:0004810]; CCACCA tRNA nucleotidyltransferase activity [GO:0160016]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0000049; GO:0001680; GO:0004810; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0008033; GO:0042803; GO:0072344; GO:0106354; GO:0160016; GO:1902494; GO:1990180
GN017923	GN017923.1	Q90964	63.2	204	403	451	3.55e-68	225	FOXG1_CHICK	Forkhead box protein G1 (FoxG1) (Brain factor 1) (BF-1) (BF1) (cBF-1) (CEQ 3-1) (Forkhead-related protein FKHL1) (N-62-5) (Proto-oncogene C-QIN)	Gallus gallus (Chicken)	negative regulation of DNA-templated transcription [GO:0045892]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; sequence-specific double-stranded DNA binding [GO:1990837]	nucleus [GO:0005634]	GO:0003700; GO:0005634; GO:0006357; GO:0045892; GO:1990837
GN017928	GN017928.1	Q8TCS8	53.5	710	734	783	2.30e-248	711	PNPT1_HUMAN	Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)	Homo sapiens (Human)	cellular response to interferon-beta [GO:0035458]; cellular response to oxidative stress [GO:0034599]; liver regeneration [GO:0097421]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA polyadenylation [GO:0097222]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrion organization [GO:0007005]; mRNA catabolic process [GO:0006402]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; positive regulation of mRNA catabolic process [GO:0061014]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; regulation of cellular respiration [GO:0043457]; regulation of cellular senescence [GO:2000772]; response to cAMP [GO:0051591]; response to growth hormone [GO:0060416]; RNA catabolic process [GO:0006401]; RNA import into mitochondrion [GO:0035927]; rRNA import into mitochondrion [GO:0035928]	3'-5'-RNA exonuclease activity [GO:0000175]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; poly(G) binding [GO:0034046]; poly(U) RNA binding [GO:0008266]; polyribonucleotide nucleotidyltransferase activity [GO:0004654]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial degradosome [GO:0045025]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ribosome [GO:0005840]	GO:0000175; GO:0000957; GO:0000958; GO:0000962; GO:0000964; GO:0000965; GO:0003723; GO:0004654; GO:0005737; GO:0005739; GO:0005758; GO:0005759; GO:0005789; GO:0005829; GO:0005840; GO:0006401; GO:0006402; GO:0007005; GO:0008266; GO:0034046; GO:0034599; GO:0035198; GO:0035458; GO:0035927; GO:0035928; GO:0042802; GO:0043457; GO:0045025; GO:0051260; GO:0051591; GO:0060416; GO:0061014; GO:0070207; GO:0071042; GO:0097222; GO:0097421; GO:2000627; GO:2000772
GN017933	GN017933.1	Q9DBM0	42.9	606	662	673	2.56e-152	459	ABCG8_MOUSE	ATP-binding cassette sub-family G member 8 (EC 7.6.2.-) (Sterolin-2)	Mus musculus (Mouse)	cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; intestinal cholesterol absorption [GO:0030299]; negative regulation of intestinal cholesterol absorption [GO:0045796]; negative regulation of intestinal phytosterol absorption [GO:0010949]; phospholipid transport [GO:0015914]; sterol homeostasis [GO:0055092]; sterol transport [GO:0015918]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; protein heterodimerization activity [GO:0046982]	apical plasma membrane [GO:0016324]; ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0005524; GO:0005886; GO:0010949; GO:0015914; GO:0015918; GO:0016324; GO:0016887; GO:0030299; GO:0033344; GO:0042626; GO:0042632; GO:0043190; GO:0043235; GO:0045796; GO:0046982; GO:0055092; GO:0140359
GN017934	GN017934.1	Q99PE7	40.5	615	648	652	8.59e-153	459	ABCG5_RAT	ATP-binding cassette sub-family G member 5 (EC 7.6.2.-) (Sterolin-1)	Rattus norvegicus (Rat)	cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; negative regulation of intestinal cholesterol absorption [GO:0045796]; negative regulation of intestinal phytosterol absorption [GO:0010949]; response to ionizing radiation [GO:0010212]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; sterol transport [GO:0015918]; triglyceride homeostasis [GO:0070328]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cholesterol transfer activity [GO:0120020]; protein heterodimerization activity [GO:0046982]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; ATP-binding cassette (ABC) transporter complex [GO:0043190]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0005524; GO:0005886; GO:0007584; GO:0009410; GO:0010212; GO:0010949; GO:0014850; GO:0015918; GO:0016020; GO:0016324; GO:0016887; GO:0031667; GO:0033344; GO:0042626; GO:0042632; GO:0043190; GO:0043235; GO:0045177; GO:0045796; GO:0046982; GO:0070328; GO:0120020; GO:0140359
GN017935	GN017935.1	Q61241	55.4	271	311	365	3.89e-98	296	TSSK1_MOUSE	Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) (Serine/threonine-protein kinase 22A)	Mus musculus (Mouse)	gene expression [GO:0010467]; skin development [GO:0043588]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; motile cilium [GO:0031514]	GO:0000287; GO:0001669; GO:0004674; GO:0005524; GO:0007283; GO:0007286; GO:0010467; GO:0031514; GO:0043588; GO:0044877; GO:0106310
GN017936	GN017936.1	O54863	46.7	274	322	358	4.13e-71	227	TSSK2_MOUSE	Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (Serine/threonine-protein kinase 22B)	Mus musculus (Mouse)	protein autophosphorylation [GO:0046777]; spermatid development [GO:0007286]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]	acrosomal vesicle [GO:0001669]; centriole [GO:0005814]; cytoplasm [GO:0005737]	GO:0000287; GO:0001669; GO:0004674; GO:0005524; GO:0005737; GO:0005814; GO:0007286; GO:0044877; GO:0046777; GO:0106310
GN017937	GN017937.1	Q9D565	33.5	1135	1208	1086	2.35e-196	604	WDR64_MOUSE	WD repeat-containing protein 64	Mus musculus (Mouse)			cytoplasm [GO:0005737]; motile cilium [GO:0031514]	GO:0005737; GO:0031514
GN017938	GN017938.1	O42358	50.8	199	300	292	2.65e-48	166	RX3_DANRE	Retinal homeobox protein Rx3	Danio rerio (Zebrafish) (Brachydanio rerio)	adenohypophysis development [GO:0021984]; camera-type eye morphogenesis [GO:0048593]; cell fate specification [GO:0001708]; embryonic camera-type eye morphogenesis [GO:0048596]; eye development [GO:0001654]; eye field cell fate commitment involved in camera-type eye formation [GO:0060898]; forebrain development [GO:0030900]; hypothalamus development [GO:0021854]; neural crest cell migration [GO:0001755]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001654; GO:0001708; GO:0001755; GO:0005634; GO:0006357; GO:0021854; GO:0021984; GO:0030900; GO:0045944; GO:0048593; GO:0048596; GO:0060041; GO:0060898
GN017942	GN017942.1	F1RWC3	35.0	143	223	3625	3.03e-12	68.9	CUBN_PIG	Cubilin (Intrinsic factor-cobalamin receptor)	Sus scrofa (Pig)		calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]	apical plasma membrane [GO:0016324]; endosome [GO:0005768]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]	GO:0004252; GO:0005509; GO:0005765; GO:0005768; GO:0005886; GO:0016324
GN017943	GN017943.1	Q6ZG77	40.0	423	1186	490	1.60e-84	287	DCDA_ORYSJ	Probable diaminopimelate decarboxylase, chloroplastic (DAP decarboxylase) (DAPDC) (EC 4.1.1.20)	Oryza sativa subsp. japonica (Rice)		diaminopimelate decarboxylase activity [GO:0008836]	chloroplast [GO:0009507]	GO:0008836; GO:0009507
GN017945	GN017945.1	Q0E908	27.3	473	578	818	4.53e-41	162	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN017946	GN017946.1	G5EF51	30.2	483	734	723	1.75e-50	191	KY_CAEEL	Lim and transglutaminase domain protein ltd-1 (Kyphoscoliosis inactive peptidase homolog ltd-1)	Caenorhabditis elegans	muscle structure development [GO:0061061]		cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; striated muscle dense body [GO:0055120]	GO:0005737; GO:0005856; GO:0005911; GO:0055120; GO:0061061
GN017947	GN017947.1	Q0E908	28.1	477	754	818	7.95e-46	179	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN017948	GN017948.1	Q0E908	24.5	462	762	818	9.96e-28	123	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN017949	GN017949.1	G5EF51	22.8	421	706	723	5.48e-11	69.7	KY_CAEEL	Lim and transglutaminase domain protein ltd-1 (Kyphoscoliosis inactive peptidase homolog ltd-1)	Caenorhabditis elegans	muscle structure development [GO:0061061]		cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; striated muscle dense body [GO:0055120]	GO:0005737; GO:0005856; GO:0005911; GO:0055120; GO:0061061
GN017955	GN017955.1	Q28CE7	53.6	686	686	777	1.36e-235	676	ZNT5_XENTR	Proton-coupled zinc antiporter SLC30A5 (Solute carrier family 30 member 5) (Zinc transporter 5) (ZnT-5)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	GPI anchor biosynthetic process [GO:0006506]; intracellular zinc ion homeostasis [GO:0006882]; zinc ion import into Golgi lumen [GO:1904257]; zinc ion import into organelle [GO:0062111]	zinc ion transmembrane transporter activity [GO:0005385]; zinc:proton antiporter activity [GO:0140826]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi cis cisterna membrane [GO:1990674]; Golgi membrane [GO:0000139]; lateral plasma membrane [GO:0016328]; secretory granule membrane [GO:0030667]; trans-Golgi network membrane [GO:0032588]	GO:0000139; GO:0005385; GO:0005737; GO:0005789; GO:0005794; GO:0006506; GO:0006882; GO:0012507; GO:0016328; GO:0030667; GO:0031410; GO:0032588; GO:0062111; GO:0140826; GO:1904257; GO:1990674
GN017959	GN017959.1	Q3T0G1	34.3	102	291	213	4.88e-10	61.6	THAP1_BOVIN	THAP domain-containing protein 1	Bos taurus (Bovine)	DNA-templated transcription [GO:0006351]; endothelial cell proliferation [GO:0001935]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; PML body [GO:0016605]	GO:0000978; GO:0001935; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0006357; GO:0007346; GO:0008270; GO:0016605; GO:0042803; GO:0043565
GN017960	GN017960.1	O16025	32.2	706	663	1066	1.33e-98	328	AOSL_PLEHO	Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (AOS) (EC 4.2.1.-) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)]	Plexaura homomalla (Black sea rod)	arachidonate metabolic process [GO:0019369]; lipid oxidation [GO:0034440]	arachidonate 8(R)-lipoxygenase activity [GO:0047677]; heme binding [GO:0020037]; iron ion binding [GO:0005506]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0005506; GO:0005737; GO:0016020; GO:0019369; GO:0020037; GO:0034440; GO:0047677
GN017961	GN017961.1	Q3T0G1	34.3	102	291	213	4.88e-10	61.6	THAP1_BOVIN	THAP domain-containing protein 1	Bos taurus (Bovine)	DNA-templated transcription [GO:0006351]; endothelial cell proliferation [GO:0001935]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; PML body [GO:0016605]	GO:0000978; GO:0001935; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0006357; GO:0007346; GO:0008270; GO:0016605; GO:0042803; GO:0043565
GN017963	GN017963.1	Q7SZ59	52.1	169	221	255	9.68e-51	168	RASLC_DANRE	Ras-like protein family member 12 (EC 3.6.5.2) (RAS-like protein Ris)	Danio rerio (Zebrafish) (Brachydanio rerio)	small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005525; GO:0005886; GO:0007264
GN017964	GN017964.1	A8WHP3	59.1	538	592	657	1.98e-236	670	SC5A9_DANRE	Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9)	Danio rerio (Zebrafish) (Brachydanio rerio)		carbohydrate:monoatomic cation symporter activity [GO:0005402]; hexose transmembrane transporter activity [GO:0015149]; solute:sodium symporter activity [GO:0015370]; transmembrane transporter activity [GO:0022857]	plasma membrane [GO:0005886]	GO:0005402; GO:0005886; GO:0015149; GO:0015370; GO:0022857
GN017965	GN017965.1	Q6GNQ4	34.6	289	323	361	1.45e-28	116	GKP1A_XENLA	G kinase-anchoring protein 1-A	Xenopus laevis (African clawed frog)	signal transduction [GO:0007165]		Golgi apparatus [GO:0005794]	GO:0005794; GO:0007165
GN017967	GN017967.1	B0G143	48.2	253	265	294	1.76e-80	247	UCPB_DICDI	Mitochondrial substrate carrier family protein ucpB (Solute carrier family 25 member 30 homolog) (Uncoupler protein B)	Dictyostelium discoideum (Social amoeba)	response to cadmium ion [GO:0046686]; transmembrane transport [GO:0055085]		mitochondrial inner membrane [GO:0005743]	GO:0005743; GO:0046686; GO:0055085
GN017975	GN017975.1	O93530	27.0	374	348	1436	2.36e-22	102	WRN_XENLA	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Focus-forming activity 1) (FFA-1) (Werner syndrome protein homolog) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Xenopus laevis (African clawed frog)	DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; four-way junction helicase activity [GO:0009378]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000723; GO:0000724; GO:0000781; GO:0003676; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006259; GO:0006260; GO:0008408; GO:0009378; GO:0016887; GO:0030145; GO:0032392; GO:0043138
GN017979	GN017979.1	Q5FVR5	38.4	432	427	418	4.67e-88	276	ACNT2_RAT	Acyl-coenzyme A amino acid N-acyltransferase 2 (EC 2.3.1.-)	Rattus norvegicus (Rat)	acyl-CoA metabolic process [GO:0006637]; bile acid metabolic process [GO:0008206]; fatty acid metabolic process [GO:0006631]	acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; fatty acyl-CoA hydrolase activity [GO:0047617]	peroxisome [GO:0005777]	GO:0005777; GO:0006631; GO:0006637; GO:0008206; GO:0016747; GO:0047617
GN017980	GN017980.1	Q07553	46.6	279	674	1163	1.86e-64	234	GCY3E_DROME	Guanylate cyclase 32E (EC 4.6.1.2)	Drosophila melanogaster (Fruit fly)	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0001653; GO:0004383; GO:0005524; GO:0005886; GO:0006182; GO:0007168; GO:0035556; GO:0038023
GN017982	GN017982.1	Q07553	38.8	237	671	1163	3.53e-42	168	GCY3E_DROME	Guanylate cyclase 32E (EC 4.6.1.2)	Drosophila melanogaster (Fruit fly)	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; peptide receptor activity [GO:0001653]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0001653; GO:0004383; GO:0005524; GO:0005886; GO:0006182; GO:0007168; GO:0035556; GO:0038023
GN017992	GN017992.1	P13508	35.7	115	165	1295	1.34e-15	76.6	GLP1_CAEEL	Protein glp-1 [Cleaved into: glp-1/Notch intracellular domain]	Caenorhabditis elegans	cell fate specification [GO:0001708]; cellularization [GO:0007349]; cytoplasmic streaming [GO:0099636]; embryonic pattern specification [GO:0009880]; maintenance of dauer [GO:0043055]; negative regulation of stem cell differentiation [GO:2000737]; nematode larval development [GO:0002119]; nematode pharyngeal muscle development [GO:0160096]; Notch signaling pathway [GO:0007219]; oocyte growth [GO:0001555]; positive regulation of gene expression [GO:0010628]; positive regulation of germ cell proliferation [GO:1905938]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of gene expression [GO:0010468]; regulation of germ cell proliferation [GO:1905936]; regulation of transcription by RNA polymerase II [GO:0006357]	calcium ion binding [GO:0005509]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coactivator activity [GO:0003713]; transmembrane signaling receptor activity [GO:0004888]	axon [GO:0030424]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; lateral plasma membrane [GO:0016328]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription regulator complex [GO:0090575]	GO:0001555; GO:0001708; GO:0002119; GO:0003713; GO:0004888; GO:0005509; GO:0005634; GO:0005737; GO:0005886; GO:0006357; GO:0007219; GO:0007349; GO:0009880; GO:0010468; GO:0010608; GO:0010628; GO:0012505; GO:0016328; GO:0030424; GO:0043055; GO:0045944; GO:0061629; GO:0090575; GO:0099636; GO:0160096; GO:1905936; GO:1905938; GO:2000648; GO:2000737
GN017995	GN017995.1	P31795	38.7	111	163	581	9.58e-17	79.7	POL_MLVRK	Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]	Radiation murine leukemia virus (strain Kaplan)	DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; symbiont entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826]	nucleic acid binding [GO:0003676]; RNA-directed DNA polymerase activity [GO:0003964]; RNA-DNA hybrid ribonuclease activity [GO:0004523]		GO:0003676; GO:0003964; GO:0004523; GO:0006310; GO:0015074; GO:0044826; GO:0046718; GO:0075713
GN018000	GN018000.1	P41894	58.7	75	232	384	1.88e-15	77.8	DEI_DROME	Helix-loop-helix protein delilah (Protein taxi)	Drosophila melanogaster (Fruit fly)	anatomical structure morphogenesis [GO:0009653]; cell adhesion mediated by integrin [GO:0033627]; imaginal disc-derived wing vein specification [GO:0007474]; mesoderm development [GO:0007498]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; somatic muscle development [GO:0007525]	bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]	nucleus [GO:0005634]	GO:0000981; GO:0003700; GO:0005634; GO:0006355; GO:0007474; GO:0007498; GO:0007525; GO:0009653; GO:0033627; GO:0043425; GO:0045944; GO:0046983
GN018003	GN018003.1	Q5XHH7	60.1	524	599	595	1.29e-190	551	SYVNB_XENLA	E3 ubiquitin-protein ligase synoviolin B (EC 2.3.2.27) (RING-type E3 ubiquitin transferase synoviolin B) (Synovial apoptosis inhibitor 1-B)	Xenopus laevis (African clawed frog)	ERAD pathway [GO:0036503]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]	GO:0005789; GO:0006511; GO:0016567; GO:0036503; GO:0043161; GO:0044322; GO:0050821; GO:0061630; GO:1902236
GN018004	GN018004.1	Q9YGL1	56.0	134	283	298	8.22e-43	151	SPD1B_XENLA	Speedy protein 1-B (Spy1-B) (Protein Ls27) (Rapid inducer of G2/M progression in oocytes B) (RINGO-B) (XSpy1-B) (p33 ringo-B) (xRINGO-B)	Xenopus laevis (African clawed frog)	G2/MI transition of meiotic cell cycle [GO:0008315]; oocyte maturation [GO:0001556]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of meiotic cell cycle [GO:0051446]	cyclin binding [GO:0030332]; protein kinase binding [GO:0019901]	nucleus [GO:0005634]	GO:0001556; GO:0005634; GO:0008315; GO:0019901; GO:0030332; GO:0043410; GO:0045737; GO:0051446
GN018010	GN018010.1	B1AVY7	49.6	696	4127	1312	3.21e-180	598	KI16B_MOUSE	Kinesin-like protein KIF16B	Mus musculus (Mouse)	cellular response to type II interferon [GO:0071346]; early endosome to late endosome transport [GO:0045022]; endoderm development [GO:0007492]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; formation of primary germ layer [GO:0001704]; Golgi to endosome transport [GO:0006895]; receptor catabolic process [GO:0032801]; regulation of receptor recycling [GO:0001919]; vesicle transport along microtubule [GO:0047496]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; plus-end-directed microtubule motor activity [GO:0008574]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; kinesin complex [GO:0005871]; phagocytic vesicle [GO:0045335]; spindle [GO:0005819]	GO:0001704; GO:0001919; GO:0005524; GO:0005547; GO:0005737; GO:0005768; GO:0005769; GO:0005819; GO:0005829; GO:0005871; GO:0006895; GO:0007173; GO:0007492; GO:0008017; GO:0008543; GO:0008574; GO:0031267; GO:0031901; GO:0032266; GO:0032801; GO:0035091; GO:0043325; GO:0045022; GO:0045335; GO:0047496; GO:0071346; GO:0080025
GN018022	GN018022.1	Q9QXN3	46.9	177	189	581	8.38e-43	153	TRIP4_MOUSE	Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4)	Mus musculus (Mouse)	estrogen receptor signaling pathway [GO:0030520]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of myoblast differentiation [GO:0045661]; rescue of stalled cytosolic ribosome [GO:0072344]; ribosome disassembly [GO:0032790]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]	histone acetyltransferase binding [GO:0035035]; nuclear estrogen receptor binding [GO:0030331]; nuclear receptor binding [GO:0016922]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin-like protein ligase binding [GO:0044389]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuromuscular junction [GO:0031594]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RQC-trigger complex [GO:0180022]	GO:0002020; GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0006355; GO:0008270; GO:0016604; GO:0016922; GO:0019901; GO:0030331; GO:0030520; GO:0031594; GO:0032790; GO:0032991; GO:0035035; GO:0044389; GO:0045661; GO:0045893; GO:0072344; GO:0180022; GO:1990116
GN018026	GN018026.1	P86786	31.4	194	566	284	7.58e-16	81.6	GIGA3_MAGGI	Gigasin-3a	Magallana gigas (Pacific oyster) (Crassostrea gigas)				
GN018027	GN018027.1	P08472	25.9	336	485	779	6.53e-17	87.4	M130_STRPU	Mesenchyme-specific cell surface glycoprotein (MSP130)	Strongylocentrotus purpuratus (Purple sea urchin)			plasma membrane [GO:0005886]	GO:0005886
GN018032	GN018032.1	Q8K5B2	36.8	95	140	145	3.90e-12	62.8	MCFD2_MOUSE	Multiple coagulation factor deficiency protein 2 homolog (Neural stem cell-derived neuronal survival protein)	Mus musculus (Mouse)	gene expression [GO:0010467]	calcium ion binding [GO:0005509]	cargo receptor complex [GO:0062137]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]	GO:0005509; GO:0005576; GO:0005783; GO:0005794; GO:0010467; GO:0033116; GO:0062137
GN018033	GN018033.1	Q17QZ7	39.6	826	832	847	4.40e-145	451	TTC27_BOVIN	Tetratricopeptide repeat protein 27 (TPR repeat protein 27)	Bos taurus (Bovine)				
GN018037	GN018037.1	Q9R1S8	56.7	846	866	813	0.0	970	CAN7_MOUSE	Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH)	Mus musculus (Mouse)	positive regulation of epithelial cell migration [GO:0010634]; proteolysis [GO:0006508]; self proteolysis [GO:0097264]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; MIT domain binding [GO:0090541]	centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004175; GO:0004197; GO:0004198; GO:0005634; GO:0005813; GO:0005829; GO:0006508; GO:0010634; GO:0090541; GO:0097264
GN018039	GN018039.1	Q3B8R1	32.2	684	675	678	1.78e-81	275	EMARD_RAT	Endoplasmic reticulum membrane-associated RNA degradation protein (ER membrane-associated RNA degradation protein)	Rattus norvegicus (Rat)			endoplasmic reticulum membrane [GO:0005789]	GO:0005789
GN018040	GN018040.1	Q5QD04	32.1	277	410	348	1.33e-22	101	TAAR9_MOUSE	Trace amine-associated receptor 9 (TaR-9) (Trace amine receptor 9) (mTaar9)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]	trace-amine receptor activity [GO:0001594]	plasma membrane [GO:0005886]	GO:0001594; GO:0005886; GO:0007186; GO:0007189
GN018042	GN018042.1	Q96T55	35.8	243	334	309	2.25e-42	152	KCNKG_HUMAN	Potassium channel subfamily K member 16 (2P domain potassium channel Talk-1) (TWIK-related alkaline pH-activated K(+) channel 1) (TALK-1)	Homo sapiens (Human)	endoplasmic reticulum calcium ion homeostasis [GO:0032469]; membrane repolarization during action potential [GO:0086011]; potassium ion transport [GO:0006813]; regulation of action potential [GO:0098900]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]	identical protein binding [GO:0042802]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; protein heterodimerization activity [GO:0046982]	endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]	GO:0005267; GO:0005743; GO:0005789; GO:0005886; GO:0006813; GO:0015271; GO:0022841; GO:0032469; GO:0042802; GO:0046982; GO:0051279; GO:0061178; GO:0086011; GO:0098900
GN018043	GN018043.1	Q80WT5	37.7	183	912	931	4.25e-16	87.0	AFTIN_MOUSE	Aftiphilin	Mus musculus (Mouse)		clathrin binding [GO:0030276]	AP-1 adaptor complex [GO:0030121]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network membrane [GO:0032588]	GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0030121; GO:0030276; GO:0032588; GO:0048471
GN018045	GN018045.1	Q5ZLL7	38.0	808	796	751	2.05e-157	479	WDR91_CHICK	WD repeat-containing protein 91	Gallus gallus (Chicken)	early endosome to late endosome transport [GO:0045022]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]	phosphatidylinositol 3-kinase inhibitor activity [GO:0141039]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; late endosome membrane [GO:0031902]	GO:0005829; GO:0010008; GO:0031901; GO:0031902; GO:0035014; GO:0045022; GO:0051898; GO:0141039
GN018046	GN018046.1	Q17QM9	28.6	161	161	164	2.31e-14	69.7	CNRP1_BOVIN	CB1 cannabinoid receptor-interacting protein 1 (CRIP-1)	Bos taurus (Bovine)		type 1 cannabinoid receptor binding [GO:0031718]	plasma membrane [GO:0005886]	GO:0005886; GO:0031718
GN018050	GN018050.1	Q63276	48.5	97	111	420	2.91e-18	81.6	BAAT_RAT	Bile acid-CoA:amino acid N-acyltransferase (BACAT) (BAT) (EC 2.3.1.65) (Bile acid-CoA thioesterase) (Choloyl-CoA hydrolase) (EC 3.1.2.27) (Glycine N-choloyltransferase) (Kan-1) (Long-chain fatty-acyl-CoA hydrolase) (EC 3.1.2.2)	Rattus norvegicus (Rat)	acyl-CoA metabolic process [GO:0006637]; animal organ regeneration [GO:0031100]; bile acid biosynthetic process [GO:0006699]; bile acid conjugation [GO:0002152]; bile acid metabolic process [GO:0008206]; fatty acid metabolic process [GO:0006631]; glycine metabolic process [GO:0006544]; liver development [GO:0001889]; taurine metabolic process [GO:0019530]	acyltransferase activity, transferring groups other than amino-acyl groups [GO:0016747]; choloyl-CoA hydrolase activity [GO:0033882]; fatty acyl-CoA hydrolase activity [GO:0047617]; glycine N-acyltransferase activity [GO:0047961]; glycine N-choloyltransferase activity [GO:0047963]; long-chain fatty acyl-CoA hydrolase activity [GO:0052816]; medium-chain fatty acyl-CoA hydrolase activity [GO:0052815]; very long-chain fatty acyl-CoA hydrolase activity [GO:0052817]	cytosol [GO:0005829]; peroxisome [GO:0005777]	GO:0001889; GO:0002152; GO:0005777; GO:0005829; GO:0006544; GO:0006631; GO:0006637; GO:0006699; GO:0008206; GO:0016747; GO:0019530; GO:0031100; GO:0033882; GO:0047617; GO:0047961; GO:0047963; GO:0052815; GO:0052816; GO:0052817
GN018052	GN018052.1	P20397	32.0	253	491	651	1.84e-25	113	NUCL_XENLA	Nucleolin (Protein C23)	Xenopus laevis (African clawed frog)	3'-UTR-mediated mRNA stabilization [GO:0070935]	mRNA binding [GO:0003729]	nucleolus [GO:0005730]	GO:0003729; GO:0005730; GO:0070935
GN018054	GN018054.1	A0JMK9	36.4	448	1018	863	6.67e-44	176	CAF1A_DANRE	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA replication-dependent chromatin assembly [GO:0006335]		CAF-1 complex [GO:0033186]; nucleus [GO:0005634]	GO:0005634; GO:0006335; GO:0033186
GN018056	GN018056.1	Q9W2Q5	56.8	183	183	189	3.32e-72	219	CIB2_DROME	Calcium and integrin-binding family member 2	Drosophila melanogaster (Fruit fly)	calcium ion homeostasis [GO:0055074]; phototransduction [GO:0007602]	calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]	cytoplasm [GO:0005737]	GO:0000287; GO:0005509; GO:0005737; GO:0007602; GO:0055074
GN018060	GN018060.1	P86786	30.6	193	537	284	1.27e-15	80.9	GIGA3_MAGGI	Gigasin-3a	Magallana gigas (Pacific oyster) (Crassostrea gigas)				
GN018065	GN018065.1	Q90W04	24.2	157	179	159	6.80e-13	66.2	NGB_TETNG	Neuroglobin (Nitrite reductase) (EC 1.7.-.-)	Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)	cellular response to hypoxia [GO:0071456]	GDP-dissociation inhibitor activity [GO:0005092]; heme binding [GO:0020037]; nitrite reductase activity [GO:0098809]; oxygen binding [GO:0019825]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]	GO:0005092; GO:0005759; GO:0005829; GO:0019825; GO:0020037; GO:0071456; GO:0098809
GN018070	GN018070.1	P77851	28.7	178	290	281	2.86e-18	85.9	HBD_THETC	3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157) (Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)	Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032) (Clostridium thermosaccharolyticum)	butyrate metabolic process [GO:0019605]; fatty acid beta-oxidation [GO:0006635]	3-hydroxybutyryl-CoA dehydrogenase activity [GO:0008691]; NAD+ binding [GO:0070403]		GO:0006635; GO:0008691; GO:0019605; GO:0070403
GN018080	GN018080.1	Q94KI8	27.7	256	274	733	9.50e-15	77.4	TPC1_ARATH	Two pore calcium channel protein 1 (Calcium channel protein 1) (AtCCH1) (Fatty acid oxygenation up-regulated protein 2) (Voltage-dependent calcium channel protein TPC1) (AtTPC1)	Arabidopsis thaliana (Mouse-ear cress)	calcium ion transport [GO:0006816]; calcium-mediated signaling [GO:0019722]; regulation of jasmonic acid biosynthetic process [GO:0080141]; regulation of stomatal movement [GO:0010119]; seed germination [GO:0009845]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; voltage-gated calcium channel activity [GO:0005245]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; plant-type vacuole [GO:0000325]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]; vacuole [GO:0005773]	GO:0000325; GO:0005245; GO:0005262; GO:0005509; GO:0005773; GO:0005774; GO:0005794; GO:0005829; GO:0005886; GO:0006816; GO:0009845; GO:0010119; GO:0019722; GO:0042802; GO:0080141
GN018081	GN018081.1	Q9EQJ0	38.3	128	162	817	1.78e-18	84.7	TPC1_MOUSE	Two pore calcium channel protein 1 (Voltage-dependent calcium channel protein TPC1)	Mus musculus (Mouse)	endocytosis involved in viral entry into host cell [GO:0075509]; positive regulation of autophagy [GO:0010508]; sodium ion transmembrane transport [GO:0035725]	identical protein binding [GO:0042802]; intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity [GO:0097682]; ligand-gated sodium channel activity [GO:0015280]; NAADP-sensitive calcium-release channel activity [GO:0072345]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; protein homodimerization activity [GO:0042803]; syntaxin binding [GO:0019905]; voltage-gated channel activity [GO:0022832]; voltage-gated sodium channel activity [GO:0005248]	early endosome membrane [GO:0031901]; endolysosome [GO:0036019]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; recycling endosome membrane [GO:0055038]	GO:0005248; GO:0005765; GO:0010008; GO:0010508; GO:0015280; GO:0016020; GO:0019905; GO:0022832; GO:0031901; GO:0035725; GO:0036019; GO:0042802; GO:0042803; GO:0055038; GO:0072345; GO:0075509; GO:0080025; GO:0097682
GN018087	GN018087.1	P36573	31.6	275	557	279	1.63e-32	129	LEC1_CAEEL	32 kDa beta-galactoside-binding lectin (32 kDa GBP)	Caenorhabditis elegans		carbohydrate binding [GO:0030246]; galactoside binding [GO:0016936]	cuticular extracellular matrix [GO:0060102]; membrane raft [GO:0045121]	GO:0016936; GO:0030246; GO:0045121; GO:0060102
GN018088	GN018088.1	Q5D0K2	25.9	374	464	428	3.52e-12	71.6	CCKAR_CANLF	Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R)	Canis lupus familiaris (Dog) (Canis familiaris)	cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of hormone secretion [GO:0046883]	cholecystokinin receptor activity [GO:0004951]	plasma membrane [GO:0005886]	GO:0004951; GO:0005886; GO:0007186; GO:0032870; GO:0046883
GN018089	GN018089.1	Q6AY25	43.8	192	225	221	2.06e-51	169	TMED3_RAT	Transmembrane emp24 domain-containing protein 3 (p24 family protein gamma-4) (p24gamma4)	Rattus norvegicus (Rat)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]		COPI vesicle coat [GO:0030126]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]	GO:0005783; GO:0005789; GO:0005793; GO:0005794; GO:0006888; GO:0007030; GO:0030126; GO:0032580; GO:0033116
GN018092	GN018092.1	Q96CN9	30.6	767	727	775	8.25e-61	221	GCC1_HUMAN	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1)	Homo sapiens (Human)		small GTPase binding [GO:0031267]	cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]	GO:0000138; GO:0000139; GO:0005794; GO:0005829; GO:0031267
GN018093	GN018093.1	Q76MT4	40.1	606	806	842	1.12e-100	333	ESF1_RAT	ESF1 homolog (ABT1-associated protein)	Rattus norvegicus (Rat)	rRNA processing [GO:0006364]	RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0003723; GO:0005654; GO:0005730; GO:0006364
GN018094	GN018094.1	P49900	54.5	321	333	323	1.96e-119	350	ARGI1_AQUCT	Arginase, hepatic (EC 3.5.3.1)	Aquarana catesbeiana (American bullfrog) (Rana catesbeiana)	arginine metabolic process [GO:0006525]; urea cycle [GO:0000050]	arginase activity [GO:0004053]; manganese ion binding [GO:0030145]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000050; GO:0004053; GO:0005634; GO:0005829; GO:0006525; GO:0030145
GN018096	GN018096.1	A1Z877	28.5	1297	1228	1350	1.18e-95	338	NDG_DROME	Nidogen (Entactin)	Drosophila melanogaster (Fruit fly)	basement membrane assembly involved in embryonic body morphogenesis [GO:2001197]; basement membrane organization [GO:0071711]; cell-matrix adhesion [GO:0007160]; regulation of basement membrane organization [GO:0110011]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]	basement membrane [GO:0005604]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005201; GO:0005509; GO:0005576; GO:0005604; GO:0005886; GO:0007160; GO:0071711; GO:0110011; GO:2001197
GN018102	GN018102.1	E9PSU6	53.0	1431	2114	2343	0.0	1419	PCX1_RAT	Pecanex-like protein 1 (Pecanex 1) (Pecanex homolog protein 1)	Rattus norvegicus (Rat)			membrane [GO:0016020]	GO:0016020
GN018103	GN018103.1	C3XR70	52.3	258	313	302	1.43e-75	236	ENOPH_BRAFL	Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase)	Branchiostoma floridae (Florida lancelet) (Amphioxus)		acireductone synthase activity [GO:0043874]; magnesium ion binding [GO:0000287]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000287; GO:0005634; GO:0005737; GO:0043874
GN018105	GN018105.1	Q32P73	80.5	87	101	125	3.74e-50	157	RPB9_BOVIN	DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I)	Bos taurus (Bovine)	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II [GO:0001193]; transcription by RNA polymerase II [GO:0006366]; transcription initiation at RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]	DNA-directed RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	nucleolus [GO:0005730]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]	GO:0001193; GO:0003676; GO:0003899; GO:0005634; GO:0005665; GO:0005730; GO:0006283; GO:0006366; GO:0006367; GO:0008270
GN018106	GN018106.1	Q8R127	60.6	127	127	429	4.72e-39	138	SCPDL_MOUSE	Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-)	Mus musculus (Mouse)	glycolipid biosynthetic process [GO:0009247]		lipid droplet [GO:0005811]; midbody [GO:0030496]; mitochondrion [GO:0005739]	GO:0005739; GO:0005811; GO:0009247; GO:0030496
GN018107	GN018107.1	Q5R5C9	43.1	130	146	429	1.71e-29	114	SCPDL_PONAB	Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	glycolipid biosynthetic process [GO:0009247]		lipid droplet [GO:0005811]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0005739; GO:0005811; GO:0005886; GO:0009247
GN018112	GN018112.1	Q8K157	44.4	342	353	342	3.16e-92	282	GALM_MOUSE	Galactose mutarotase (EC 5.1.3.3) (Aldose 1-epimerase)	Mus musculus (Mouse)	carbohydrate metabolic process [GO:0005975]; galactose catabolic process via UDP-galactose, Leloir pathway [GO:0033499]; galactose metabolic process [GO:0006012]; glucose metabolic process [GO:0006006]	aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	cytoplasm [GO:0005737]	GO:0004034; GO:0004553; GO:0005737; GO:0005975; GO:0006006; GO:0006012; GO:0030246; GO:0033499
GN018113	GN018113.1	Q66HG4	40.7	351	359	342	1.07e-80	253	GALM_RAT	Galactose mutarotase (EC 5.1.3.3) (Aldose 1-epimerase)	Rattus norvegicus (Rat)	carbohydrate metabolic process [GO:0005975]; galactose catabolic process via UDP-galactose, Leloir pathway [GO:0033499]; galactose metabolic process [GO:0006012]; glucose metabolic process [GO:0006006]	aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	cytoplasm [GO:0005737]	GO:0004034; GO:0004553; GO:0005737; GO:0005975; GO:0006006; GO:0006012; GO:0030246; GO:0033499
GN018115	GN018115.1	Q61670	52.6	175	312	476	1.38e-39	147	HLX_MOUSE	H2.0-like homeobox protein (Homeobox protein HLX1)	Mus musculus (Mouse)	animal organ development [GO:0048513]; embryonic digestive tract morphogenesis [GO:0048557]; enteric nervous system development [GO:0048484]; liver development [GO:0001889]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of organ growth [GO:0046622]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; skeletal muscle tissue development [GO:0007519]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000981; GO:0001889; GO:0005634; GO:0007519; GO:0008284; GO:0043565; GO:0045627; GO:0045629; GO:0046622; GO:0048484; GO:0048513; GO:0048557
GN018116	GN018116.1	Q14624	39.2	569	620	930	1.68e-119	380	ITIH4_HUMAN	Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4]	Homo sapiens (Human)	acute-phase response [GO:0006953]; hyaluronan metabolic process [GO:0030212]; response to cytokine [GO:0034097]	endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]	blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089]	GO:0004866; GO:0004867; GO:0005576; GO:0006953; GO:0030212; GO:0031012; GO:0031089; GO:0034097; GO:0070062; GO:0072562
GN018120	GN018120.1	Q6R5J2	32.9	170	881	1464	3.33e-15	84.3	DISP1_DANRE	Protein dispatched homolog 1 (Protein chameleon)	Danio rerio (Zebrafish) (Brachydanio rerio)	adenohypophysis development [GO:0021984]; animal organ morphogenesis [GO:0009887]; anterior/posterior pattern specification [GO:0009952]; blood circulation [GO:0008015]; embryonic cranial skeleton morphogenesis [GO:0048701]; inner ear development [GO:0048839]; muscle cell fate specification [GO:0042694]; retinal ganglion cell axon guidance [GO:0031290]; skeletal muscle tissue development [GO:0007519]; smoothened signaling pathway [GO:0007224]		membrane [GO:0016020]	GO:0007224; GO:0007519; GO:0008015; GO:0009887; GO:0009952; GO:0016020; GO:0021984; GO:0031290; GO:0042694; GO:0048701; GO:0048839
GN018122	GN018122.1	Q6R5J2	32.9	170	595	1464	1.50e-15	84.3	DISP1_DANRE	Protein dispatched homolog 1 (Protein chameleon)	Danio rerio (Zebrafish) (Brachydanio rerio)	adenohypophysis development [GO:0021984]; animal organ morphogenesis [GO:0009887]; anterior/posterior pattern specification [GO:0009952]; blood circulation [GO:0008015]; embryonic cranial skeleton morphogenesis [GO:0048701]; inner ear development [GO:0048839]; muscle cell fate specification [GO:0042694]; retinal ganglion cell axon guidance [GO:0031290]; skeletal muscle tissue development [GO:0007519]; smoothened signaling pathway [GO:0007224]		membrane [GO:0016020]	GO:0007224; GO:0007519; GO:0008015; GO:0009887; GO:0009952; GO:0016020; GO:0021984; GO:0031290; GO:0042694; GO:0048701; GO:0048839
GN018124	GN018124.1	Q9P2Z0	37.2	86	131	257	3.01e-13	67.4	THA10_HUMAN	THAP domain-containing protein 10	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]		GO:0043565
GN018125	GN018125.1	Q5EA79	49.9	343	349	342	6.20e-112	332	GALM_BOVIN	Galactose mutarotase (EC 5.1.3.3) (Aldose 1-epimerase)	Bos taurus (Bovine)	galactose catabolic process via UDP-galactose, Leloir pathway [GO:0033499]; glucose metabolic process [GO:0006006]	aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246]	cytoplasm [GO:0005737]	GO:0004034; GO:0005737; GO:0006006; GO:0030246; GO:0033499
GN018127	GN018127.1	Q7SXU0	42.8	250	237	249	2.28e-32	121	EI3JA_DANRE	Eukaryotic translation initiation factor 3 subunit J-A (eIF3j-A) (Eukaryotic translation initiation factor 3 subunit 1-A) (eIF-3-alpha-A) (eIF3 p35-A)	Danio rerio (Zebrafish) (Brachydanio rerio)	formation of cytoplasmic translation initiation complex [GO:0001732]	translation initiation factor activity [GO:0003743]	eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]	GO:0001732; GO:0003743; GO:0005852; GO:0016282; GO:0033290
GN018128	GN018128.1	A6H8Z2	52.6	194	323	402	1.46e-70	227	F221B_HUMAN	Protein FAM221B	Homo sapiens (Human)				
GN018138	GN018138.1	Q2KJG3	74.5	495	499	559	3.11e-283	781	SYNC_BOVIN	Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS)	Bos taurus (Bovine)	asparaginyl-tRNA aminoacylation [GO:0006421]	asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]	GO:0003676; GO:0004816; GO:0005524; GO:0005737; GO:0006421
GN018139	GN018139.1	Q7TPD0	50.6	945	1017	1041	0.0	929	INT3_MOUSE	Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic G2/M transition checkpoint [GO:0044818]; regulation of transcription elongation by RNA polymerase II [GO:0034243]; response to ionizing radiation [GO:0010212]; RNA polymerase II transcription initiation surveillance [GO:0160240]; snRNA processing [GO:0016180]		cytoplasm [GO:0005737]; INTAC complex [GO:0160232]; integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; SOSS complex [GO:0070876]	GO:0000724; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0006974; GO:0010212; GO:0016180; GO:0032039; GO:0034243; GO:0035861; GO:0044818; GO:0070876; GO:0160232; GO:0160240
GN018140	GN018140.1	Q13033	57.2	780	916	797	8.68e-279	796	STRN3_HUMAN	Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)	Homo sapiens (Human)	negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0035331]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of hippo signaling [GO:0035330]; response to estradiol [GO:0032355]	armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; protein-macromolecule adaptor activity [GO:0030674]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]	GO:0000122; GO:0005516; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005886; GO:0019901; GO:0030425; GO:0030674; GO:0031267; GO:0032355; GO:0032991; GO:0033147; GO:0035330; GO:0035331; GO:0043025; GO:0044877; GO:0045892; GO:0045944; GO:0051721; GO:0070016; GO:0090443; GO:0098794
GN018142	GN018142.1	Q9WV92	58.7	341	646	929	1.82e-134	420	E41L3_MOUSE	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]	Mus musculus (Mouse)	actomyosin structure organization [GO:0031032]; axon development [GO:0061564]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; paranodal junction maintenance [GO:1990227]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell shape [GO:0008360]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]	actin binding [GO:0003779]; cytoskeletal protein-membrane anchor activity [GO:0106006]; structural constituent of cytoskeleton [GO:0005200]	cell junction [GO:0030054]; cell-cell junction [GO:0005911]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]	GO:0002175; GO:0003779; GO:0005200; GO:0005829; GO:0005856; GO:0005886; GO:0005911; GO:0005929; GO:0008360; GO:0014069; GO:0030054; GO:0030865; GO:0030866; GO:0030913; GO:0031032; GO:0033270; GO:0036064; GO:0043217; GO:0044224; GO:0048812; GO:0061564; GO:0071205; GO:0072659; GO:0098696; GO:0098794; GO:0098978; GO:0106006; GO:1990227
GN018145	GN018145.1	Q8HY24	33.0	306	306	542	8.02e-47	168	S22A8_RABIT	Organic anion transporter 3 (rOAT3) (Organic anion/dicarboxylate exchanger) (Solute carrier family 22 member 8)	Oryctolagus cuniculus (Rabbit)	prostaglandin transport [GO:0015732]	antiporter activity [GO:0015297]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	basolateral plasma membrane [GO:0016323]	GO:0015297; GO:0015732; GO:0016323; GO:0022857; GO:0042910
GN018149	GN018149.1	Q8CG80	51.7	116	551	238	6.56e-27	112	SHF_MOUSE	SH2 domain-containing adapter protein F	Mus musculus (Mouse)	signal transduction [GO:0007165]			GO:0007165
GN018150	GN018150.1	P17538	43.8	89	370	263	1.08e-19	90.9	CTRB1_HUMAN	Chymotrypsinogen B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C]	Homo sapiens (Human)	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]	extracellular region [GO:0005576]	GO:0004252; GO:0005576; GO:0006508
GN018153	GN018153.1	P11834	27.7	220	307	345	4.68e-16	80.9	OPCM_BOVIN	Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule)	Bos taurus (Bovine)	heterophilic cell-cell adhesion [GO:0007157]; regulation of synapse assembly [GO:0051963]		plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	GO:0005886; GO:0007157; GO:0014069; GO:0051963
GN018154	GN018154.1	Q640B4	36.3	768	761	612	3.79e-140	429	MUS81_XENTR	Structure-specific endonuclease subunit MUS81 (EC 3.1.22.-) (Crossover junction endonuclease MUS81)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	DNA catabolic process [GO:0006308]; double-strand break repair via break-induced replication [GO:0000727]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]	crossover junction DNA endonuclease activity [GO:0008821]; DNA binding [GO:0003677]	Holliday junction resolvase complex [GO:0048476]; nucleolus [GO:0005730]	GO:0000712; GO:0000727; GO:0003677; GO:0005730; GO:0006308; GO:0008821; GO:0031297; GO:0031573; GO:0048476
GN018155	GN018155.1	Q3V3N7	55.1	573	593	593	4.20e-225	639	BBS1_MOUSE	BBSome complex member BBS1 (Bardet-Biedl syndrome 1 protein homolog)	Mus musculus (Mouse)	adult behavior [GO:0030534]; brain morphogenesis [GO:0048854]; cartilage development [GO:0051216]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; dendrite development [GO:0016358]; fat cell differentiation [GO:0045444]; fertilization [GO:0009566]; Golgi to plasma membrane protein transport [GO:0043001]; hippocampus development [GO:0021766]; hormone metabolic process [GO:0042445]; intracellular protein localization [GO:0008104]; intraciliary retrograde transport [GO:0035721]; lipid metabolic process [GO:0006629]; microtubule cytoskeleton organization [GO:0000226]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; non-motile cilium assembly [GO:1905515]; olfactory behavior [GO:0042048]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell morphogenesis [GO:0008594]; protein localization to cilium [GO:0061512]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; response to endoplasmic reticulum stress [GO:0034976]; retina development in camera-type eye [GO:0060041]; retina homeostasis [GO:0001895]; sensory perception of smell [GO:0007608]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual perception [GO:0007601]	patched binding [GO:0005113]; phosphoprotein binding [GO:0051219]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; signaling receptor binding [GO:0005102]; smoothened binding [GO:0005119]	axoneme [GO:0005930]; BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; motile cilium [GO:0031514]	GO:0000226; GO:0001764; GO:0001895; GO:0005102; GO:0005113; GO:0005119; GO:0005813; GO:0005929; GO:0005930; GO:0006629; GO:0007601; GO:0007608; GO:0008104; GO:0008594; GO:0009566; GO:0016358; GO:0021591; GO:0021756; GO:0021766; GO:0021987; GO:0030534; GO:0031514; GO:0034451; GO:0034464; GO:0034976; GO:0035721; GO:0036064; GO:0042048; GO:0042445; GO:0043001; GO:0045444; GO:0045494; GO:0048854; GO:0051216; GO:0051219; GO:0060041; GO:0060170; GO:0060271; GO:0060296; GO:0061351; GO:0061512; GO:0061629; GO:1905515
GN018156	GN018156.1	Q6VV64	31.8	280	405	394	2.34e-25	109	KCNKI_MOUSE	Potassium channel subfamily K member 18 (Two-pore-domain potassium channel TRESK)	Mus musculus (Mouse)	cellular response to pH [GO:0071467]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transport [GO:0006813]; regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0032829]	calcium-activated potassium channel activity [GO:0015269]; outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]	plasma membrane [GO:0005886]	GO:0005886; GO:0006813; GO:0015269; GO:0015271; GO:0022841; GO:0032829; GO:0071467; GO:0097623
GN018158	GN018158.1	P08478	40.6	652	795	935	2.91e-157	484	AMDA_XENLA	Peptidyl-glycine alpha-amidating monooxygenase A (PAM-A) (Peptide C-terminal alpha-amidating enzyme I) (AE-I) (Peptidyl-glycine alpha-amidating monooxygenase I) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase A (PHM-A) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase A (EC 4.3.2.5) (Peptidylamidoglycolate lyase-A) (PAL-A)]	Xenopus laevis (African clawed frog)	peptide amidation [GO:0001519]	copper ion binding [GO:0005507]; peptidylamidoglycolate lyase activity [GO:0004598]; peptidylglycine monooxygenase activity [GO:0004504]	extracellular region [GO:0005576]; transport vesicle membrane [GO:0030658]	GO:0001519; GO:0004504; GO:0004598; GO:0005507; GO:0005576; GO:0030658
GN018159	GN018159.1	O02467	35.7	283	270	320	6.12e-40	144	ASPG_SPOFR	N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (AGA) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain]	Spodoptera frugiperda (Fall armyworm)		N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity [GO:0003948]	lysosome [GO:0005764]	GO:0003948; GO:0005764
GN018160	GN018160.1	Q96M60	32.5	351	643	508	7.58e-45	170	F227B_HUMAN	Protein FAM227B	Homo sapiens (Human)				
GN018161	GN018161.1	Q86W34	41.2	177	378	360	6.68e-33	129	AMZ2_HUMAN	Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2)	Homo sapiens (Human)	proteolysis [GO:0006508]	metallopeptidase activity [GO:0008237]	nucleoplasm [GO:0005654]	GO:0005654; GO:0006508; GO:0008237
GN018162	GN018162.1	P15330	56.4	282	605	999	3.45e-97	322	DORS_DROME	Embryonic polarity protein dorsal	Drosophila melanogaster (Fruit fly)	canonical NF-kappaB signal transduction [GO:0007249]; dorsal/ventral axis specification [GO:0009950]; dorsal/ventral pattern formation [GO:0009953]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; melanization defense response [GO:0035006]; non-canonical NF-kappaB signal transduction [GO:0038061]; peripheral nervous system neuron development [GO:0048935]; positive regulation of antimicrobial peptide production [GO:0002225]; positive regulation of hemocyte differentiation [GO:0045612]; positive regulation of hemocyte proliferation [GO:0035208]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of hemocyte proliferation [GO:0035206]; response to cytokine [GO:0034097]; Toll signaling pathway [GO:0008063]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; high mobility group box 1 binding [GO:0070379]; identical protein binding [GO:0042802]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; subsynaptic reticulum [GO:0071212]	GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0002225; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006954; GO:0006955; GO:0007249; GO:0008063; GO:0009950; GO:0009953; GO:0031594; GO:0034097; GO:0035006; GO:0035206; GO:0035208; GO:0038061; GO:0042802; GO:0043565; GO:0045087; GO:0045612; GO:0045944; GO:0048935; GO:0070379; GO:0071212; GO:0140297
GN018166	GN018166.1	Q86X10	44.0	1555	1514	1494	0.0	1120	RLGPB_HUMAN	Ral GTPase-activating protein subunit beta (p170)	Homo sapiens (Human)	activation of GTPase activity [GO:0090630]; Ral protein signal transduction [GO:0032484]; regulation of small GTPase mediated signal transduction [GO:0051056]	GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982]		GO:0005096; GO:0032484; GO:0046982; GO:0051056; GO:0090630
GN018170	GN018170.1	Q5RFR8	65.6	294	301	308	1.81e-139	399	COPE_PONAB	Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005198; GO:0006888; GO:0006890; GO:0006891; GO:0030126
GN018171	GN018171.1	Q6NVC9	29.8	342	292	846	9.36e-34	133	JMY_DANRE	Junction-mediating and -regulatory protein	Danio rerio (Zebrafish) (Brachydanio rerio)	'de novo' actin filament nucleation [GO:0070060]; actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cellular response to starvation [GO:0009267]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of apoptotic process [GO:0043065]	actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; microtubule binding [GO:0008017]; transcription coactivator activity [GO:0003713]	autophagosome membrane [GO:0000421]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; endomembrane system [GO:0012505]; nucleus [GO:0005634]	GO:0000421; GO:0003713; GO:0003779; GO:0005634; GO:0005737; GO:0005856; GO:0008017; GO:0009267; GO:0012505; GO:0031252; GO:0031410; GO:0034314; GO:0043065; GO:0070060; GO:0070358; GO:0071933; GO:0072332
GN018173	GN018173.1	Q9P2K5	42.5	259	517	600	1.16e-51	188	MYEF2_HUMAN	Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156)	Homo sapiens (Human)	myotube differentiation [GO:0014902]; neuron differentiation [GO:0030182]	RNA binding [GO:0003723]	nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0014902; GO:0030182
GN018174	GN018174.1	Q6UUV9	37.8	704	660	634	1.57e-71	246	CRTC1_HUMAN	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)	Homo sapiens (Human)	cellular response to cAMP [GO:0071320]; entrainment of circadian clock by photoperiod [GO:0043153]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homotetramerization [GO:0051289]	cAMP response element binding protein binding [GO:0008140]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0008140; GO:0016604; GO:0043153; GO:0045944; GO:0051289; GO:0071320
GN018177	GN018177.1	O09174	57.3	372	378	381	1.68e-153	440	AMACR_MOUSE	Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase)	Mus musculus (Mouse)	bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; fatty acid metabolic process [GO:0006631]; isoprenoid catabolic process [GO:0008300]	alpha-methylacyl-CoA racemase activity [GO:0008111]; signaling receptor binding [GO:0005102]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]	GO:0005102; GO:0005737; GO:0005739; GO:0005777; GO:0005886; GO:0006631; GO:0006699; GO:0008111; GO:0008206; GO:0008300
GN018180	GN018180.1	P07511	74.4	172	211	484	1.12e-87	269	GLYC_RABIT	Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (L-allo-threonine/L-threonine aldolase SHMT1) (Serine methylase)	Oryctolagus cuniculus (Rabbit)	'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; cellular response to tetrahydrofolate [GO:1904482]; DNA replication [GO:0006260]; dTMP biosynthetic process [GO:0006231]; folic acid metabolic process [GO:0046655]; glycine metabolic process [GO:0006544]; L-serine catabolic process [GO:0006565]; L-serine metabolic process [GO:0006563]; protein homotetramerization [GO:0051289]; purine nucleobase biosynthetic process [GO:0009113]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	glycine hydroxymethyltransferase activity [GO:0004372]; hydroxytrimethyllysine aldolase activity [GO:0120567]; L-allo-threonine aldolase activity [GO:0008732]; lamin binding [GO:0005521]; mRNA 5'-UTR binding [GO:0048027]; mRNA regulatory element binding translation repressor activity [GO:0000900]; phenylserine aldolase activity [GO:0050179]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]; threonine aldolase activity [GO:0004793]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000900; GO:0004372; GO:0004793; GO:0005521; GO:0005634; GO:0005657; GO:0005737; GO:0005739; GO:0005829; GO:0006207; GO:0006231; GO:0006260; GO:0006544; GO:0006563; GO:0006565; GO:0008732; GO:0009113; GO:0030170; GO:0035999; GO:0042803; GO:0046653; GO:0046655; GO:0048027; GO:0050179; GO:0051289; GO:0070905; GO:0120567; GO:1904482
GN018183	GN018183.1	Q96FW1	61.7	128	128	271	1.98e-51	166	OTUB1_HUMAN	Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)	Homo sapiens (Human)	DNA damage response [GO:0006974]; negative regulation of double-strand break repair [GO:2000780]; positive regulation of TORC1 signaling [GO:1904263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]	cysteine-type deubiquitinase activity [GO:0004843]; deNEDDylase activity [GO:0019784]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase inhibitor activity [GO:0055105]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	GO:0004843; GO:0005654; GO:0005737; GO:0005829; GO:0006974; GO:0016579; GO:0019784; GO:0031625; GO:0043130; GO:0055105; GO:0070062; GO:0071108; GO:1904263; GO:2000780
GN018184	GN018184.1	Q54P77	41.6	548	581	551	1.20e-121	373	4CL1_DICDI	Probable 4-coumarate--CoA ligase 1 (4CL 1) (EC 6.2.1.12) (4-coumaroyl-CoA synthase 1)	Dictyostelium discoideum (Social amoeba)		4-coumarate-CoA ligase activity [GO:0016207]		GO:0016207
GN018185	GN018185.1	Q5ZL12	44.2	764	782	779	1.90e-187	557	PPR21_CHICK	Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (Ferry endosomal RAB5 effector complex subunit 2) (Fy-2) (KLRAQ motif-containing protein 1)	Gallus gallus (Chicken)			early endosome [GO:0005769]; membrane [GO:0016020]	GO:0005769; GO:0016020
GN018186	GN018186.1	O14678	46.3	542	542	606	4.53e-168	492	ABCD4_HUMAN	Lysosomal cobalamin transporter ABCD4 (EC 7.6.2.8) (ATP-binding cassette sub-family D member 4) (PMP70-related protein) (P70R) (Peroxisomal membrane protein 1-like) (PXMP1-L) (Peroxisomal membrane protein 69) (PMP69)	Homo sapiens (Human)	cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; long-chain fatty acid import into peroxisome [GO:0015910]; peroxisome organization [GO:0007031]; transmembrane transport [GO:0055085]; very long-chain fatty acid catabolic process [GO:0042760]	ABC-type vitamin B12 transporter activity [GO:0015420]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; identical protein binding [GO:0042802]; long-chain fatty acid transmembrane transporter activity [GO:0005324]	ATP-binding cassette (ABC) transporter complex [GO:0043190]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; peroxisome [GO:0005777]	GO:0005324; GO:0005524; GO:0005765; GO:0005777; GO:0005789; GO:0007031; GO:0009235; GO:0015420; GO:0015889; GO:0015910; GO:0016020; GO:0016887; GO:0042626; GO:0042760; GO:0042802; GO:0043190; GO:0055085
GN018187	GN018187.1	Q8CFJ7	41.3	288	308	288	6.47e-72	226	S2545_MOUSE	Methylated amino-acid transporter SLC25A45 (Solute carrier family 25 member 45)	Mus musculus (Mouse)	carnitine biosynthetic process [GO:0045329]	dimethylarginine transmembrane transporter activity [GO:7770027]; N(6),N(6),N(6)-trimethyl-L-lysine transmembrane transporter activity [GO:7770026]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0045329; GO:7770026; GO:7770027
GN018192	GN018192.1	Q5VUA4	33.2	265	1825	2279	6.26e-28	127	ZN318_HUMAN	Zinc finger protein 318 (Endocrine regulatory protein)	Homo sapiens (Human)	negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]	nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]	GO:0003676; GO:0005654; GO:0008270; GO:0042803; GO:0045892; GO:0045893
GN018193	GN018193.1	A0A345BJN8	32.0	219	351	919	3.66e-23	104	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN018195	GN018195.1	Q9U1M8	44.8	752	2283	2357	4.18e-171	587	MYOI_DICDI	Myosin-I heavy chain (Class VII unconventional myosin) (DdMVII) (DdM7)	Dictyostelium discoideum (Social amoeba)	actin filament-based movement [GO:0030048]; cell morphogenesis [GO:0000902]; cell-substrate adhesion [GO:0031589]; endocytosis [GO:0006897]; filopodium assembly [GO:0046847]; phagocytosis [GO:0006909]; response to calcium ion [GO:0051592]; spore germination [GO:0009847]	actin filament binding [GO:0051015]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; microtubule binding [GO:0008017]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; filopodium [GO:0030175]; filopodium tip [GO:0032433]; membrane [GO:0016020]; myosin complex [GO:0016459]; phagocytic cup [GO:0001891]	GO:0000146; GO:0000902; GO:0001891; GO:0005524; GO:0005829; GO:0005938; GO:0006897; GO:0006909; GO:0008017; GO:0009847; GO:0015629; GO:0016020; GO:0016459; GO:0030048; GO:0030175; GO:0031252; GO:0031589; GO:0032433; GO:0046847; GO:0051015; GO:0051592
GN018197	GN018197.1	P53042	62.8	462	625	499	1.60e-219	622	PPP5_RAT	Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PPT)	Rattus norvegicus (Rat)	cellular response to cadmium ion [GO:0071276]; cellular response to hydrogen peroxide [GO:0070301]; negative regulation of apoptotic process [GO:0043066]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-serine dephosphorylation [GO:0070262]; positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway [GO:2000324]; protein dephosphorylation [GO:0006470]; response to arachidonate [GO:1904550]; response to lead ion [GO:0010288]; response to morphine [GO:0043278]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; G-protein alpha-subunit binding [GO:0001965]; heat shock protein binding [GO:0031072]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein serine/threonine phosphatase activity [GO:0004722]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]; proximal dendrite [GO:1990635]	GO:0001933; GO:0001965; GO:0003723; GO:0004721; GO:0004722; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006470; GO:0008017; GO:0010288; GO:0016791; GO:0030291; GO:0030544; GO:0031072; GO:0031435; GO:0032991; GO:0042802; GO:0043025; GO:0043066; GO:0043204; GO:0043278; GO:0043409; GO:0043531; GO:0044877; GO:0051879; GO:0070262; GO:0070301; GO:0071276; GO:0101031; GO:1904550; GO:1990635; GO:2000324
GN018198	GN018198.1	Q96FN9	58.4	161	164	168	3.54e-62	192	DTD2_HUMAN	D-aminoacyl-tRNA deacylase 2 (EC 3.1.1.96) (Animalia-specific tRNA deacylase) (ATD) (D-tyrosyl-tRNA(Tyr) deacylase 2) (L-alanyl-tRNA deacylase)	Homo sapiens (Human)	aminoacyl-tRNA metabolism involved in translational fidelity [GO:0106074]; tRNA metabolic process [GO:0006399]	Ala-tRNA(Thr) deacylase activity [GO:0106105]; D-aminoacyl-tRNA deacylase activity [GO:0051499]; D-tyrosyl-tRNA(Tyr) deacylase activity [GO:0051500]; Gly-tRNA(Ala) deacylase activity [GO:0106026]	cytoplasm [GO:0005737]	GO:0005737; GO:0006399; GO:0051499; GO:0051500; GO:0106026; GO:0106074; GO:0106105
GN018199	GN018199.1	P36993	58.7	361	775	390	2.29e-145	434	PPM1B_MOUSE	Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)	Mus musculus (Mouse)	N-terminal protein myristoylation [GO:0006499]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein dephosphorylation [GO:0006470]; regulation of canonical NF-kappaB signal transduction [GO:0043122]	magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0000287; GO:0004722; GO:0005634; GO:0005730; GO:0005829; GO:0006470; GO:0006499; GO:0016020; GO:0030145; GO:0032688; GO:0035970; GO:0043122; GO:0043124; GO:0050687; GO:0090263; GO:1901223
GN018201	GN018201.1	Q803R5	55.1	758	803	829	3.35e-293	830	CMTR1_DANRE	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (FtsJ methyltransferase domain-containing protein 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	7-methylguanosine mRNA capping [GO:0006370]; mRNA processing [GO:0006397]	methyltransferase cap1 activity [GO:0004483]; nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003676; GO:0004483; GO:0005634; GO:0005737; GO:0006370; GO:0006397
GN018204	GN018204.1	Q5VWZ2	52.1	188	190	237	2.54e-62	196	LYPL1_HUMAN	Lysophospholipase-like protein 1 (EC 3.1.2.22)	Homo sapiens (Human)	negative regulation of cGAS/STING signaling pathway [GO:0160049]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]	hydrolase activity, acting on ester bonds [GO:0016788]; palmitoyl-(protein) hydrolase activity [GO:0008474]; phosphatidylcholine lysophospholipase A1 activity [GO:0004622]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0004622; GO:0005737; GO:0005739; GO:0005829; GO:0008474; GO:0016788; GO:0042997; GO:0160049
GN018207	GN018207.1	Q7KN94	78.4	213	235	330	1.35e-112	328	ETFA_DROME	Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) (Protein walrus)	Drosophila melanogaster (Fruit fly)	fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]	catalytic activity [GO:0003824]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]	mitochondrial electron transfer flavoprotein complex [GO:0017133]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003824; GO:0005739; GO:0005759; GO:0006635; GO:0009055; GO:0017133; GO:0033539; GO:0050660
GN018208	GN018208.1	Q63415	42.9	832	936	937	4.26e-218	647	PCSK6_RAT	Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4)	Rattus norvegicus (Rat)	determination of left/right symmetry [GO:0007368]; glycoprotein metabolic process [GO:0009100]; nerve growth factor production [GO:0032902]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]; secretion by cell [GO:0032940]; zygotic determination of anterior/posterior axis, embryo [GO:0007354]	endopeptidase activity [GO:0004175]; heparin binding [GO:0008201]; nerve growth factor binding [GO:0048406]; serine-type endopeptidase activity [GO:0004252]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0004175; GO:0004252; GO:0005576; GO:0005794; GO:0007354; GO:0007368; GO:0008201; GO:0009100; GO:0009986; GO:0016020; GO:0016485; GO:0016486; GO:0031012; GO:0032902; GO:0032940; GO:0048406
GN018210	GN018210.1	E9QHE3	27.0	174	623	634	3.40e-09	63.5	RN207_DANRE	RING finger protein 207	Danio rerio (Zebrafish) (Brachydanio rerio)	positive regulation of membrane repolarization during cardiac muscle cell action potential [GO:1905033]; positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905026]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207]	Hsp70 protein binding [GO:0030544]; transmembrane transporter binding [GO:0044325]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]	GO:0005737; GO:0008270; GO:0030544; GO:0044325; GO:0048471; GO:0055117; GO:1901207; GO:1905026; GO:1905033
GN018217	GN018217.1	Q9NZ43	34.1	211	228	259	1.41e-23	98.2	USE1_HUMAN	Vesicle transport protein USE1 (Putative MAPK-activating protein PM26) (USE1-like protein) (p31)	Homo sapiens (Human)	lysosomal transport [GO:0007041]; protein catabolic process [GO:0030163]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; secretion by cell [GO:0032940]	SNAP receptor activity [GO:0005484]	COPI-coated vesicle [GO:0030137]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; SNARE complex [GO:0031201]	GO:0005484; GO:0005783; GO:0005789; GO:0006890; GO:0007041; GO:0030137; GO:0030163; GO:0031201; GO:0032940
GN018219	GN018219.1	Q92048	44.6	186	225	350	8.33e-48	163	WNT2_DANRE	Protein Wnt-2	Danio rerio (Zebrafish) (Brachydanio rerio)	canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cell migration involved in gastrulation [GO:0042074]; hepatocyte proliferation [GO:0072574]; liver development [GO:0001889]; neuron differentiation [GO:0030182]; swim bladder development [GO:0048794]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]	extracellular region [GO:0005576]	GO:0001889; GO:0005109; GO:0005125; GO:0005576; GO:0030182; GO:0042074; GO:0045165; GO:0048794; GO:0060070; GO:0072574
GN018221	GN018221.1	Q9VZF4	30.2	169	192	1326	2.45e-12	68.2	FBXW7_DROME	F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (Protein archipelago)	Drosophila melanogaster (Fruit fly)	branch fusion, open tracheal system [GO:0035147]; cellular response to hypoxia [GO:0071456]; DNA endoreduplication [GO:0042023]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of growth [GO:0045926]; negative regulation of imaginal disc growth [GO:0045571]; protein ubiquitination [GO:0016567]; regulation of exit from mitosis [GO:0007096]; regulation of mitotic nuclear division [GO:0007088]; regulation of proteolysis [GO:0030162]; regulation of transcription by RNA polymerase II [GO:0006357]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; trachea development [GO:0060438]; ventral cord development [GO:0007419]	cyclin binding [GO:0030332]; ubiquitin-specific protease binding [GO:1990381]	nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0005634; GO:0006357; GO:0007088; GO:0007096; GO:0007419; GO:0016567; GO:0019005; GO:0030162; GO:0030332; GO:0031146; GO:0035147; GO:0042023; GO:0045571; GO:0045926; GO:0060253; GO:0060438; GO:0071456; GO:1900038; GO:1990381
GN018222	GN018222.1	Q9BUH8	39.5	119	258	593	2.52e-18	87.4	BEGIN_HUMAN	Brain-enriched guanylate kinase-associated protein	Homo sapiens (Human)	evoked excitatory postsynaptic potential [GO:0098817]		cytoplasm [GO:0005737]; membrane [GO:0016020]; postsynapse [GO:0098794]; synapse [GO:0045202]	GO:0005737; GO:0016020; GO:0045202; GO:0098794; GO:0098817
GN018224	GN018224.1	Q66II5	52.6	137	162	348	2.91e-46	157	T3HPD_XENTR	Trans-L-3-hydroxyproline dehydratase (EC 4.2.1.77) (Trans-3-hydroxy-L-proline dehydratase)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		hydro-lyase activity [GO:0016836]; trans-L-3-hydroxyproline dehydratase activity [GO:0050346]		GO:0016836; GO:0050346
GN018225	GN018225.1	P57103	53.8	567	581	927	1.95e-190	562	NAC3_HUMAN	Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3)	Homo sapiens (Human)	calcium ion export across plasma membrane [GO:1990034]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; intracellular calcium ion homeostasis [GO:0006874]; learning [GO:0007612]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; modulation of excitatory postsynaptic potential [GO:0098815]; myelination [GO:0042552]; negative regulation of intracellular signal transduction [GO:1902532]; oligodendrocyte differentiation [GO:0048709]; regulation of cardiac conduction [GO:1903779]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]; telencephalon development [GO:0021537]	calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration [GO:1905060]; calcium:sodium antiporter activity [GO:0005432]	anchoring junction [GO:0070161]; axon [GO:0030424]; axon terminus [GO:0043679]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; synapse [GO:0045202]	GO:0005432; GO:0005741; GO:0005789; GO:0005829; GO:0005874; GO:0005886; GO:0006851; GO:0006874; GO:0007154; GO:0007611; GO:0007612; GO:0007613; GO:0014069; GO:0014819; GO:0016528; GO:0021537; GO:0030424; GO:0030425; GO:0031594; GO:0035725; GO:0042383; GO:0042552; GO:0043025; GO:0043197; GO:0043204; GO:0043679; GO:0045202; GO:0045211; GO:0048471; GO:0048709; GO:0050808; GO:0051560; GO:0060291; GO:0060402; GO:0070161; GO:0070588; GO:0071320; GO:0071456; GO:0098703; GO:0098794; GO:0098815; GO:1902532; GO:1903779; GO:1905060; GO:1990034
GN018226	GN018226.1	O46606	40.1	713	706	875	8.19e-154	471	DDHD1_BOVIN	Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase)	Bos taurus (Bovine)	phosphatidylinositol metabolic process [GO:0046488]	glycerophospholipase activity [GO:0004620]; glycerophospholipid phospholipase A1 activity [GO:0008970]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]	GO:0004620; GO:0005737; GO:0008970; GO:0046488; GO:0046872
GN018227	GN018227.1	P58545	72.9	424	495	530	1.44e-228	641	BTBD3_MOUSE	BTB/POZ domain-containing protein 3	Mus musculus (Mouse)	cerebral cortex development [GO:0021987]; dendrite morphogenesis [GO:0048813]; neurogenesis [GO:0022008]	identical protein binding [GO:0042802]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0021987; GO:0022008; GO:0042802; GO:0048813
GN018228	GN018228.1	Q8CFK2	65.1	149	154	676	2.34e-58	195	TF3B_MOUSE	Transcription factor IIIB 90 kDa subunit (TFIIIB90) (mTFIIIB90) (B-related factor 1) (BRF-1)	Mus musculus (Mouse)	DNA-templated transcription initiation [GO:0006352]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of mRNA stability [GO:0043488]; transcription by RNA polymerase III [GO:0006383]; transcription preinitiation complex assembly [GO:0070897]	RNA polymerase III general transcription initiation factor activity [GO:0000995]; RNA polymerase III type 3 promoter sequence-specific DNA binding [GO:0001006]; TBP-class protein binding [GO:0017025]	nucleus [GO:0005634]; transcription factor TFIIIB complex [GO:0000126]; transcription preinitiation complex [GO:0097550]	GO:0000126; GO:0000995; GO:0001006; GO:0005634; GO:0006352; GO:0006383; GO:0017025; GO:0043488; GO:0045945; GO:0070897; GO:0097550
GN018229	GN018229.1	Q7ZVK3	55.1	187	203	379	1.03e-61	199	SIR2_DANRE	NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-2) (EC 2.3.1.-) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to caloric restriction [GO:0061433]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cilium assembly [GO:0060271]; hemopoiesis [GO:0030097]; negative regulation of angiogenesis [GO:0016525]; negative regulation of autophagy [GO:0010507]; negative regulation of oligodendrocyte progenitor proliferation [GO:0070446]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA binding [GO:0043388]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; rDNA heterochromatin formation [GO:0000183]; regulation of cell cycle [GO:0051726]; regulation of tubulin deacetylation [GO:0090043]; swimming behavior [GO:0036269]; tubulin deacetylation [GO:0090042]	histone benzoyllysine debenzoylase activity [GO:0140228]; histone deacetylase activity [GO:0004407]; histone deacetylase activity, NAD-dependent [GO:0017136]; histone H4K16 deacetylase activity, NAD-dependent [GO:0046970]; histone methacryllysine demethacrylase activity [GO:0140219]; NAD+ binding [GO:0070403]; NAD-dependent protein demyristoylase activity [GO:0140773]; NAD-dependent protein depalmitoylase activity [GO:0140774]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; tubulin deacetylase activity [GO:0042903]	centriole [GO:0005814]; centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cell projection [GO:0097386]; heterochromatin [GO:0000792]; juxtaparanode region of axon [GO:0044224]; meiotic spindle [GO:0072687]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; myelin sheath [GO:0043209]; nucleus [GO:0005634]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; Schmidt-Lanterman incisure [GO:0043220]; spindle [GO:0005819]	GO:0000122; GO:0000183; GO:0000792; GO:0004407; GO:0005634; GO:0005694; GO:0005737; GO:0005813; GO:0005814; GO:0005819; GO:0005829; GO:0006476; GO:0010507; GO:0016525; GO:0017136; GO:0030097; GO:0030496; GO:0032436; GO:0033010; GO:0033270; GO:0034599; GO:0034979; GO:0036269; GO:0042177; GO:0042903; GO:0043204; GO:0043209; GO:0043220; GO:0043388; GO:0044224; GO:0045944; GO:0046970; GO:0048471; GO:0051726; GO:0060271; GO:0061433; GO:0070403; GO:0070446; GO:0071456; GO:0072686; GO:0072687; GO:0090042; GO:0090043; GO:0097386; GO:0140219; GO:0140228; GO:0140773; GO:0140774; GO:1900119; GO:2000378
GN018230	GN018230.1	Q7ZVK3	51.7	87	91	379	1.28e-21	89.7	SIR2_DANRE	NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-2) (EC 2.3.1.-) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to caloric restriction [GO:0061433]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cilium assembly [GO:0060271]; hemopoiesis [GO:0030097]; negative regulation of angiogenesis [GO:0016525]; negative regulation of autophagy [GO:0010507]; negative regulation of oligodendrocyte progenitor proliferation [GO:0070446]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA binding [GO:0043388]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deacetylation [GO:0006476]; rDNA heterochromatin formation [GO:0000183]; regulation of cell cycle [GO:0051726]; regulation of tubulin deacetylation [GO:0090043]; swimming behavior [GO:0036269]; tubulin deacetylation [GO:0090042]	histone benzoyllysine debenzoylase activity [GO:0140228]; histone deacetylase activity [GO:0004407]; histone deacetylase activity, NAD-dependent [GO:0017136]; histone H4K16 deacetylase activity, NAD-dependent [GO:0046970]; histone methacryllysine demethacrylase activity [GO:0140219]; NAD+ binding [GO:0070403]; NAD-dependent protein demyristoylase activity [GO:0140773]; NAD-dependent protein depalmitoylase activity [GO:0140774]; NAD-dependent protein lysine deacetylase activity [GO:0034979]; tubulin deacetylase activity [GO:0042903]	centriole [GO:0005814]; centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cell projection [GO:0097386]; heterochromatin [GO:0000792]; juxtaparanode region of axon [GO:0044224]; meiotic spindle [GO:0072687]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; myelin sheath [GO:0043209]; nucleus [GO:0005634]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; Schmidt-Lanterman incisure [GO:0043220]; spindle [GO:0005819]	GO:0000122; GO:0000183; GO:0000792; GO:0004407; GO:0005634; GO:0005694; GO:0005737; GO:0005813; GO:0005814; GO:0005819; GO:0005829; GO:0006476; GO:0010507; GO:0016525; GO:0017136; GO:0030097; GO:0030496; GO:0032436; GO:0033010; GO:0033270; GO:0034599; GO:0034979; GO:0036269; GO:0042177; GO:0042903; GO:0043204; GO:0043209; GO:0043220; GO:0043388; GO:0044224; GO:0045944; GO:0046970; GO:0048471; GO:0051726; GO:0060271; GO:0061433; GO:0070403; GO:0070446; GO:0071456; GO:0072686; GO:0072687; GO:0090042; GO:0090043; GO:0097386; GO:0140219; GO:0140228; GO:0140773; GO:0140774; GO:1900119; GO:2000378
GN018232	GN018232.1	Q9HBF4	42.2	855	854	777	1.38e-237	688	ZFYV1_HUMAN	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1)	Homo sapiens (Human)	cellular response to starvation [GO:0009267]; host-mediated activation of viral genome replication [GO:0044829]; lipid droplet formation [GO:0140042]; macroautophagy [GO:0016236]	1-phosphatidylinositol binding [GO:0005545]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; zinc ion binding [GO:0008270]	autophagosome [GO:0005776]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of omegasome membrane [GO:0097629]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; lipid droplet [GO:0005811]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; mitochondrion [GO:0005739]; omegasome [GO:1990462]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site [GO:0000407]	GO:0000407; GO:0005545; GO:0005547; GO:0005739; GO:0005776; GO:0005783; GO:0005789; GO:0005794; GO:0005795; GO:0005811; GO:0008270; GO:0009267; GO:0016236; GO:0032266; GO:0043325; GO:0044233; GO:0044829; GO:0048471; GO:0097629; GO:0140042; GO:1990462
GN018233	GN018233.1	Q92541	47.8	584	694	710	1.25e-121	382	RTF1_HUMAN	RNA polymerase-associated protein RTF1 homolog	Homo sapiens (Human)	chromatin organization [GO:0006325]; endodermal cell fate commitment [GO:0001711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; stem cell population maintenance [GO:0019827]; transcription elongation by RNA polymerase II [GO:0006368]	RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]	Cdc73/Paf1 complex [GO:0016593]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0001711; GO:0003697; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0006325; GO:0006368; GO:0016593; GO:0019827
GN018236	GN018236.1	Q8N1W2	75.5	49	798	664	3.66e-14	80.1	ZN710_HUMAN	Zinc finger protein 710	Homo sapiens (Human)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0003700; GO:0005634; GO:0006357
GN018237	GN018237.1	P20918	26.8	373	798	812	1.23e-21	104	PLMN_MOUSE	Plasminogen [Cleaved into: Plasmin (EC 3.4.21.7); Plasmin heavy chain A; Plasmin light chain B; Angiostatin]	Mus musculus (Mouse)	biological process involved in interaction with symbiont [GO:0051702]; blood coagulation [GO:0007596]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; fibrinolysis [GO:0042730]; labyrinthine layer blood vessel development [GO:0060716]; mononuclear cell migration [GO:0071674]; muscle cell cellular homeostasis [GO:0046716]; myoblast differentiation [GO:0045445]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of fibrinolysis [GO:0051919]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; tissue regeneration [GO:0042246]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]; trophoblast giant cell differentiation [GO:0060707]	apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein antigen binding [GO:1990405]; protein domain specific binding [GO:0019904]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0002020; GO:0004175; GO:0004252; GO:0005102; GO:0005576; GO:0006508; GO:0007596; GO:0009897; GO:0009986; GO:0010812; GO:0016485; GO:0016525; GO:0019899; GO:0019900; GO:0019904; GO:0022617; GO:0030163; GO:0030574; GO:0031012; GO:0034185; GO:0042246; GO:0042730; GO:0043536; GO:0045445; GO:0046716; GO:0051087; GO:0051702; GO:0051918; GO:0051919; GO:0060707; GO:0060716; GO:0071674; GO:0098685; GO:0098978; GO:0099183; GO:1990405
GN018241	GN018241.1	Q3UXZ6	30.7	339	393	364	6.25e-43	156	FA81A_MOUSE	Protein FAM81A	Mus musculus (Mouse)		molecular condensate scaffold activity [GO:0140693]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]	GO:0005737; GO:0014069; GO:0098978; GO:0099092; GO:0140693
GN018242	GN018242.1	Q13972	46.1	115	122	1273	5.10e-22	93.2	RGRF1_HUMAN	Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25)	Homo sapiens (Human)	long-term memory [GO:0007616]; negative regulation of MAPK cascade [GO:0043409]; neuron projection development [GO:0031175]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of Ras protein signal transduction [GO:0046579]; Ras protein signal transduction [GO:0007265]; regulation of Ras protein signal transduction [GO:0046578]; regulation of synaptic plasticity [GO:0048167]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]	glutamate receptor binding [GO:0035254]; guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]; growth cone [GO:0030426]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]	GO:0005085; GO:0005829; GO:0005886; GO:0007165; GO:0007265; GO:0007616; GO:0030426; GO:0031175; GO:0034976; GO:0035022; GO:0035254; GO:0043005; GO:0043409; GO:0043410; GO:0046578; GO:0046579; GO:0048167
GN018245	GN018245.1	A0A345BJN8	31.0	248	606	919	1.74e-24	112	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN018248	GN018248.1	Q9W596	42.2	476	1479	5495	4.71e-105	375	FUTSC_DROME	Microtubule-associated protein futsch (MAP1B homolog) [Cleaved into: Futsch heavy chain; Futsch light chain LC(f)]	Drosophila melanogaster (Fruit fly)	axo-dendritic transport [GO:0008088]; axonogenesis [GO:0007409]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of neuron apoptotic process [GO:0043524]; neurofilament cytoskeleton organization [GO:0060052]; olfactory learning [GO:0008355]; positive regulation of axon regeneration [GO:0048680]; regulation of microtubule depolymerization [GO:0031114]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]	actin binding [GO:0003779]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; synapse [GO:0045202]	GO:0000226; GO:0003779; GO:0005737; GO:0005829; GO:0005874; GO:0005875; GO:0007409; GO:0008017; GO:0008088; GO:0008355; GO:0008582; GO:0015630; GO:0016358; GO:0019900; GO:0030424; GO:0030425; GO:0031114; GO:0031594; GO:0043025; GO:0043524; GO:0045202; GO:0048680; GO:0048813; GO:0060052
GN018249	GN018249.1	Q9ULD9	49.0	255	1350	1512	1.91e-48	193	ZN608_HUMAN	Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36)	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]		nucleus [GO:0005634]	GO:0000122; GO:0005634; GO:0006357
GN018250	GN018250.1	Q504Y2	38.3	355	511	493	6.40e-74	245	PKDCC_HUMAN	Extracellular tyrosine-protein kinase PKDCC (EC 2.7.10.2) (Protein kinase domain-containing protein, cytoplasmic) (Protein kinase-like protein SgK493) (Sugen kinase 493) (Vertebrate lonesome kinase)	Homo sapiens (Human)	embryonic digestive tract development [GO:0048566]; lung alveolus development [GO:0048286]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of chondrocyte differentiation [GO:0032332]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]	extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]	GO:0001501; GO:0004672; GO:0004713; GO:0004715; GO:0005524; GO:0005576; GO:0005794; GO:0018108; GO:0030501; GO:0032332; GO:0042997; GO:0048286; GO:0048566; GO:0060021
GN018251	GN018251.1	Q7TN31	43.8	338	986	711	6.65e-64	233	AGGF1_MOUSE	Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (mVG5Q)	Mus musculus (Mouse)	cell adhesion [GO:0007155]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]	identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]	GO:0001938; GO:0003676; GO:0005576; GO:0005737; GO:0007155; GO:0042802; GO:0045766; GO:0048471
GN018253	GN018253.1	H2A0M3	38.0	587	645	781	9.40e-118	372	AMO_PINMG	Putative amine oxidase [copper-containing] (EC 1.4.3.-)	Margaritifera margaritifera (Freshwater pearl mussel)	amine metabolic process [GO:0009308]	copper ion binding [GO:0005507]; primary methylamine oxidase activity [GO:0008131]; quinone binding [GO:0048038]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005507; GO:0005576; GO:0005886; GO:0008131; GO:0009308; GO:0048038
GN018254	GN018254.1	Q8BQB6	31.3	240	415	394	2.55e-33	132	SAXO2_MOUSE	Stabilizer of axonemal microtubules 2	Mus musculus (Mouse)		microtubule binding [GO:0008017]	axonemal microtubule [GO:0005879]; centriole [GO:0005814]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005634; GO:0005814; GO:0005856; GO:0005879; GO:0008017; GO:0036064; GO:0036126
GN018261	GN018261.1	Q96QS3	39.2	212	318	562	4.76e-20	94.0	ARX_HUMAN	Homeobox protein ARX (Aristaless-related homeobox)	Homo sapiens (Human)	intestinal type D enteroendocrine cell differentiation [GO:7770025]; intestinal type G enteroendocrine cell differentiation [GO:7770021]; intestinal type I enteroendocrine cell differentiation [GO:7770022]; intestinal type L enteroendocrine cell differentiation [GO:7770023]; intestinal type N enteroendocrine cell differentiation [GO:7770024]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron development [GO:0048666]; pancreatic A cell differentiation [GO:0003310]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0001228; GO:0003310; GO:0003682; GO:0005634; GO:0006357; GO:0045944; GO:0048666; GO:1990837; GO:7770021; GO:7770022; GO:7770023; GO:7770024; GO:7770025
GN018266	GN018266.1	Q7Z442	28.4	824	737	2459	2.78e-69	251	PK1L2_HUMAN	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Homo sapiens (Human)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]	membrane [GO:0016020]	GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN018267	GN018267.1	Q7Z442	41.0	183	804	2459	3.14e-37	155	PK1L2_HUMAN	Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)	Homo sapiens (Human)	detection of mechanical stimulus [GO:0050982]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]	membrane [GO:0016020]	GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
GN018269	GN018269.1	Q9Z0T6	25.5	196	288	2126	2.65e-09	61.6	PKDRE_MOUSE	Polycystin family receptor for egg jelly (PKD and REJ homolog) (Polycystic kidney disease and receptor for egg jelly-related protein)	Mus musculus (Mouse)	detection of mechanical stimulus [GO:0050982]; regulation of acrosome reaction [GO:0060046]	calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]	acrosomal membrane [GO:0002080]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0002080; GO:0005262; GO:0005509; GO:0005634; GO:0005886; GO:0016020; GO:0050982; GO:0060046
GN018271	GN018271.1	O93529	63.7	179	300	319	4.95e-74	233	FOXB1_XENLA	Forkhead box protein B1 (FoxB1) (Transcription factor FKH-5)	Xenopus laevis (African clawed frog)	anatomical structure morphogenesis [GO:0009653]; axon target recognition [GO:0007412]; cell differentiation [GO:0030154]; cell migration in diencephalon [GO:0061381]; ectoderm development [GO:0007398]; floor plate development [GO:0033504]; hypothalamus cell migration [GO:0021855]; inferior colliculus development [GO:0061379]; mammillary body development [GO:0021767]; mammillothalamic axonal tract development [GO:0061374]; midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; neurogenesis [GO:0022008]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; somitogenesis [GO:0001756]; telencephalon cell migration [GO:0022029]; visual learning [GO:0008542]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001756; GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0006357; GO:0007398; GO:0007412; GO:0008542; GO:0009653; GO:0021767; GO:0021855; GO:0022008; GO:0022029; GO:0030154; GO:0030901; GO:0033504; GO:0043524; GO:0043565; GO:0061374; GO:0061379; GO:0061381
GN018272	GN018272.1	H9JW43	30.7	306	781	381	4.00e-42	161	CDA8_BOMMO	Chitin deacetylase 8 (BmCDA8) (EC 3.5.1.41) (Chitin deacetylase 17)	Bombyx mori (Silk moth)	polysaccharide catabolic process [GO:0000272]	chitin deacetylase activity [GO:0004099]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0000272; GO:0004099; GO:0005576; GO:0008270
GN018274	GN018274.1	Q497B8	30.8	130	295	414	5.21e-11	66.2	KDM8_RAT	Bifunctional peptidase and arginyl-hydroxylase JMJD5 (EC 1.14.11.73) (EC 3.4.-.-) (JmjC domain-containing protein 5) (Jumonji C domain-containing protein 5) (L-arginine (3R)-hydroxylase KDM8)	Rattus norvegicus (Rat)	circadian regulation of gene expression [GO:0032922]; fibroblast proliferation [GO:0048144]; G2/M transition of mitotic cell cycle [GO:0000086]; in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; protein destabilization [GO:0031648]; regulation of signal transduction by p53 class mediator [GO:1901796]	aminopeptidase activity [GO:0004177]; chromatin binding [GO:0003682]; endopeptidase activity [GO:0004175]; histone H3K36 demethylase activity [GO:0051864]; p53 binding [GO:0002039]; peptidyl-arginine 3-dioxygenase activity [GO:0106157]	chromosome [GO:0005694]; nucleus [GO:0005634]	GO:0000086; GO:0001701; GO:0002039; GO:0003682; GO:0004175; GO:0004177; GO:0005634; GO:0005694; GO:0031648; GO:0032922; GO:0045892; GO:0045893; GO:0048144; GO:0051864; GO:0106157; GO:1901796
GN018277	GN018277.1	Q26619	57.8	372	369	369	2.24e-136	396	KAPR_STRPU	cAMP-dependent protein kinase type II regulatory subunit	Strongylocentrotus purpuratus (Purple sea urchin)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]	cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; protein kinase A catalytic subunit binding [GO:0034236]	cAMP-dependent protein kinase complex [GO:0005952]; cytosol [GO:0005829]	GO:0004862; GO:0005829; GO:0005952; GO:0007189; GO:0030552; GO:0034236
GN018280	GN018280.1	Q497B8	30.4	224	477	414	5.04e-23	104	KDM8_RAT	Bifunctional peptidase and arginyl-hydroxylase JMJD5 (EC 1.14.11.73) (EC 3.4.-.-) (JmjC domain-containing protein 5) (Jumonji C domain-containing protein 5) (L-arginine (3R)-hydroxylase KDM8)	Rattus norvegicus (Rat)	circadian regulation of gene expression [GO:0032922]; fibroblast proliferation [GO:0048144]; G2/M transition of mitotic cell cycle [GO:0000086]; in utero embryonic development [GO:0001701]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; protein destabilization [GO:0031648]; regulation of signal transduction by p53 class mediator [GO:1901796]	aminopeptidase activity [GO:0004177]; chromatin binding [GO:0003682]; endopeptidase activity [GO:0004175]; histone H3K36 demethylase activity [GO:0051864]; p53 binding [GO:0002039]; peptidyl-arginine 3-dioxygenase activity [GO:0106157]	chromosome [GO:0005694]; nucleus [GO:0005634]	GO:0000086; GO:0001701; GO:0002039; GO:0003682; GO:0004175; GO:0004177; GO:0005634; GO:0005694; GO:0031648; GO:0032922; GO:0045892; GO:0045893; GO:0048144; GO:0051864; GO:0106157; GO:1901796
GN018281	GN018281.1	Q9HCE3	24.0	858	1734	1301	4.61e-53	209	ZN532_HUMAN	Zinc finger protein 532	Homo sapiens (Human)		DNA-binding transcription factor activity [GO:0003700]	nucleus [GO:0005634]	GO:0003700; GO:0005634
GN018282	GN018282.1	O88700	48.4	639	1343	1416	1.05e-187	595	BLM_MOUSE	RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein homolog) (mBLM) (DNA 3'-5' helicase BLM) (RecQ helicase homolog)	Mus musculus (Mouse)	alpha-beta T cell differentiation [GO:0046632]; cellular response to camptothecin [GO:0072757]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; cellular response to xenobiotic stimulus [GO:0071466]; chromosome organization [GO:0051276]; DNA damage response [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA geometric change [GO:0032392]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; negative regulation of cell division [GO:0051782]; negative regulation of DNA recombination [GO:0045910]; negative regulation of mitotic recombination [GO:0045950]; negative regulation of thymocyte apoptotic process [GO:0070244]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; replication fork processing [GO:0031297]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; resolution of DNA recombination intermediates [GO:0071139]; response to X-ray [GO:0010165]; telomere maintenance [GO:0000723]; telomeric D-loop disassembly [GO:0061820]	3'-5' DNA helicase activity [GO:0043138]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; bubble DNA binding [GO:0000405]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; p53 binding [GO:0002039]; protein homodimerization activity [GO:0042803]; single-stranded DNA binding [GO:0003697]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; nuclear chromosome [GO:0000228]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; pronucleus [GO:0045120]; protein-containing complex [GO:0032991]; RecQ family helicase-topoisomerase III complex [GO:0031422]; replication fork [GO:0005657]	GO:0000079; GO:0000228; GO:0000400; GO:0000403; GO:0000405; GO:0000723; GO:0000724; GO:0000729; GO:0000781; GO:0000800; GO:0001673; GO:0002039; GO:0003677; GO:0003678; GO:0003697; GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005730; GO:0005737; GO:0005829; GO:0006260; GO:0006281; GO:0006974; GO:0007095; GO:0008094; GO:0008270; GO:0009378; GO:0010165; GO:0016363; GO:0016605; GO:0016887; GO:0031297; GO:0031422; GO:0032392; GO:0032991; GO:0042802; GO:0042803; GO:0043138; GO:0045120; GO:0045893; GO:0045910; GO:0045950; GO:0046632; GO:0046641; GO:0051259; GO:0051260; GO:0051276; GO:0051782; GO:0051880; GO:0061749; GO:0061820; GO:0061821; GO:0061849; GO:0070244; GO:0071139; GO:0071466; GO:0071479; GO:0072711; GO:0072757; GO:1905168; GO:1905773; GO:1990414
GN018283	GN018283.1	Q9Y3U8	63.7	102	130	105	1.04e-34	119	RL36_HUMAN	Large ribosomal subunit protein eL36 (60S ribosomal protein L36)	Homo sapiens (Human)	cytoplasmic translation [GO:0002181]; negative regulation of myoblast fusion [GO:1901740]; spermatogenesis [GO:0007283]; striated muscle contraction [GO:0006941]; translation [GO:0006412]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; nucleolus [GO:0005730]	GO:0002181; GO:0003723; GO:0003735; GO:0005730; GO:0005737; GO:0005829; GO:0006412; GO:0006941; GO:0007283; GO:0016020; GO:0022625; GO:0022626; GO:1901740
GN018284	GN018284.1	E1B8U2	39.4	160	321	501	1.96e-19	92.0	THUM2_BOVIN	U6 snRNA (guanine-N(2))-methyltransferase THUMPD2 (EC 2.1.1.-) (THUMP domain-containing protein 2)	Bos taurus (Bovine)	regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; tRNA methylation [GO:0030488]	RNA binding [GO:0003723]; snRNA methyltransferase activity [GO:0106346]; tRNA (guanine) methyltransferase activity [GO:0016423]; U6 snRNA (guanine-N(2))-methyltransferase activity [GO:0160230]	nucleus [GO:0005634]; tRNA methyltransferase complex [GO:0043527]	GO:0000381; GO:0003723; GO:0005634; GO:0016423; GO:0030488; GO:0043527; GO:0106346; GO:0160230
GN018289	GN018289.1	Q93075	31.3	163	426	761	1.15e-12	73.6	TATD2_HUMAN	3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2)	Homo sapiens (Human)		hydrolase activity, acting on ester bonds [GO:0016788]	nucleoplasm [GO:0005654]	GO:0005654; GO:0016788
GN018296	GN018296.1	Q86X52	45.8	718	789	802	2.57e-224	652	CHSS1_HUMAN	Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1)	Homo sapiens (Human)	chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; negative regulation of ossification [GO:0030279]; response to nutrient levels [GO:0031667]	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [GO:0047238]; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity [GO:0050510]	extracellular region [GO:0005576]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; membrane [GO:0016020]	GO:0000139; GO:0005576; GO:0016020; GO:0030279; GO:0031667; GO:0032580; GO:0047238; GO:0050510; GO:0050650
GN018297	GN018297.1	Q5VT52	42.4	172	815	1461	1.20e-30	134	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain-containing protein 2	Homo sapiens (Human)	mRNA 3'-end processing [GO:0031124]	RNA polymerase II C-terminal domain binding [GO:0099122]; RNA polymerase II complex binding [GO:0000993]	nucleoplasm [GO:0005654]; transcription preinitiation complex [GO:0097550]	GO:0000993; GO:0005654; GO:0031124; GO:0097550; GO:0099122
GN018298	GN018298.1	Q9VCA2	29.7	438	469	548	1.24e-34	139	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN018299	GN018299.1	Q9VCA2	29.6	510	527	548	2.23e-52	189	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN018300	GN018300.1	Q9D0C1	39.5	294	289	305	9.38e-56	185	RN115_MOUSE	E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364)	Mus musculus (Mouse)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; Golgi to plasma membrane transport [GO:0006893]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; toll-like receptor 4 signaling pathway [GO:0034142]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]	GO:0004842; GO:0005634; GO:0005737; GO:0005783; GO:0005794; GO:0005829; GO:0006888; GO:0006893; GO:0034122; GO:0034123; GO:0034142; GO:0042059; GO:0043162; GO:0045335; GO:0051865; GO:0061630; GO:0070534; GO:0070936; GO:0070979
GN018301	GN018301.1	Q6NXR4	34.0	344	507	508	1.60e-44	167	TTI2_HUMAN	TELO2-interacting protein 2	Homo sapiens (Human)	positive regulation of DNA damage checkpoint [GO:2000003]; protein stabilization [GO:0050821]		nucleus [GO:0005634]; TTT Hsp90 cochaperone complex [GO:0110078]	GO:0005634; GO:0050821; GO:0110078; GO:2000003
GN018302	GN018302.1	Q5F4A1	24.1	294	277	742	2.88e-12	70.1	G2E3_CHICK	G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase)	Gallus gallus (Chicken)	heterochromatin formation [GO:0031507]; pericentric heterochromatin formation [GO:0031508]; protein localization to chromosome [GO:0034502]; protein localization to condensed nuclear chromosome [GO:1903084]; protein ubiquitination [GO:0016567]	histone H3K14 ubiquitin ligase activity [GO:0140851]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	GO:0005634; GO:0005721; GO:0005730; GO:0005737; GO:0016567; GO:0031507; GO:0031508; GO:0034502; GO:0140851; GO:1903084
GN018304	GN018304.1	Q6TFL3	31.0	931	1486	1326	3.17e-100	355	CC171_HUMAN	Coiled-coil domain-containing protein 171	Homo sapiens (Human)				
GN018305	GN018305.1	P42297	28.5	144	154	148	9.37e-10	57.0	YXIE_BACSU	Universal stress protein YxiE (USP YxiE)	Bacillus subtilis (strain 168)				
GN018306	GN018306.1	Q9ULL1	51.6	322	1827	1385	4.05e-89	324	PKHG1_HUMAN	Pleckstrin homology domain-containing family G member 1	Homo sapiens (Human)	regulation of small GTPase mediated signal transduction [GO:0051056]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005085; GO:0005654; GO:0005829; GO:0031267; GO:0051056
GN018307	GN018307.1	O95069	37.7	260	287	426	1.11e-40	149	KCNK2_HUMAN	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK1) (Two pore potassium channel TPKC1) (K2P2.1)	Homo sapiens (Human)	cardiac ventricle development [GO:0003231]; cellular response to arachidonate [GO:1904551]; cellular response to hypoxia [GO:0071456]; chloride transmembrane transport [GO:1902476]; cochlea development [GO:0090102]; detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; glutamate secretion [GO:0014047]; memory [GO:0007613]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of DNA biosynthetic process [GO:2000279]; neuronal action potential [GO:0019228]; positive regulation of cellular response to hypoxia [GO:1900039]; potassium ion transmembrane transport [GO:0071805]; regulation of synaptic transmission, GABAergic [GO:0032228]; response to axon injury [GO:0048678]	identical protein binding [GO:0042802]; ligand-gated channel activity [GO:0022834]; mechanosensitive potassium channel activity [GO:0098782]; outward rectifier potassium channel activity [GO:0015271]; potassium channel inhibitor activity [GO:0019870]; potassium ion leak channel activity [GO:0022841]; protein heterodimerization activity [GO:0046982]	apical plasma membrane [GO:0016324]; astrocyte projection [GO:0097449]; calyx of Held [GO:0044305]; cell surface [GO:0009986]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; sarcolemma [GO:0042383]	GO:0003231; GO:0005783; GO:0005789; GO:0005886; GO:0007613; GO:0009986; GO:0014047; GO:0015271; GO:0016324; GO:0019228; GO:0019870; GO:0022834; GO:0022841; GO:0030425; GO:0032228; GO:0033268; GO:0042383; GO:0042802; GO:0043025; GO:0044305; GO:0046982; GO:0048678; GO:0050976; GO:0060044; GO:0071456; GO:0071805; GO:0090102; GO:0097449; GO:0098782; GO:0098839; GO:1900039; GO:1902476; GO:1904551; GO:2000279
GN018308	GN018308.1	O75445	28.7	157	218	5202	2.56e-15	77.8	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018309	GN018309.1	O75445	41.7	127	120	5202	1.18e-23	97.8	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018311	GN018311.1	O75445	35.2	165	180	5202	2.46e-24	102	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018312	GN018312.1	O75445	41.7	127	120	5202	1.18e-23	97.8	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018314	GN018314.1	O75445	35.2	165	180	5202	2.46e-24	102	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018315	GN018315.1	O75445	30.7	440	436	5202	4.59e-62	221	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018316	GN018316.1	Q8K3K1	42.4	295	295	5125	3.12e-69	236	USH2A_RAT	Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog)	Rattus norvegicus (Rat)	animal organ morphogenesis [GO:0009887]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; tissue development [GO:0009888]	collagen binding [GO:0005518]; myosin binding [GO:0017022]	basement membrane [GO:0005604]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; terminal bouton [GO:0043195]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0009887; GO:0009888; GO:0017022; GO:0032391; GO:0032420; GO:0035315; GO:0043025; GO:0043195; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060041; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018321	GN018321.1	O75445	38.7	137	136	5202	1.51e-25	103	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018322	GN018322.1	O75445	34.8	138	254	5202	3.29e-15	78.6	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018332	GN018332.1	Q8K3K1	40.1	406	455	5125	2.11e-88	298	USH2A_RAT	Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog)	Rattus norvegicus (Rat)	animal organ morphogenesis [GO:0009887]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; tissue development [GO:0009888]	collagen binding [GO:0005518]; myosin binding [GO:0017022]	basement membrane [GO:0005604]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; terminal bouton [GO:0043195]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0009887; GO:0009888; GO:0017022; GO:0032391; GO:0032420; GO:0035315; GO:0043025; GO:0043195; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060041; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018334	GN018334.1	O75445	37.0	227	229	5202	2.43e-49	176	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018335	GN018335.1	O75445	32.2	767	734	5202	1.29e-121	405	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018337	GN018337.1	Q8K3K1	34.3	589	584	5125	2.28e-96	326	USH2A_RAT	Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog)	Rattus norvegicus (Rat)	animal organ morphogenesis [GO:0009887]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; tissue development [GO:0009888]	collagen binding [GO:0005518]; myosin binding [GO:0017022]	basement membrane [GO:0005604]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; terminal bouton [GO:0043195]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0009887; GO:0009888; GO:0017022; GO:0032391; GO:0032420; GO:0035315; GO:0043025; GO:0043195; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060041; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018339	GN018339.1	Q8K3K1	40.1	406	455	5125	2.11e-88	298	USH2A_RAT	Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog)	Rattus norvegicus (Rat)	animal organ morphogenesis [GO:0009887]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; tissue development [GO:0009888]	collagen binding [GO:0005518]; myosin binding [GO:0017022]	basement membrane [GO:0005604]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; terminal bouton [GO:0043195]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0009887; GO:0009888; GO:0017022; GO:0032391; GO:0032420; GO:0035315; GO:0043025; GO:0043195; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060041; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018342	GN018342.1	O75445	32.9	782	781	5202	1.65e-127	424	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018348	GN018348.1	Q8K3K1	41.1	304	304	5125	1.73e-67	231	USH2A_RAT	Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog)	Rattus norvegicus (Rat)	animal organ morphogenesis [GO:0009887]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; tissue development [GO:0009888]	collagen binding [GO:0005518]; myosin binding [GO:0017022]	basement membrane [GO:0005604]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; terminal bouton [GO:0043195]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0009887; GO:0009888; GO:0017022; GO:0032391; GO:0032420; GO:0035315; GO:0043025; GO:0043195; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060041; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018350	GN018350.1	Q8K3K1	41.1	304	304	5125	5.93e-67	230	USH2A_RAT	Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog)	Rattus norvegicus (Rat)	animal organ morphogenesis [GO:0009887]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; tissue development [GO:0009888]	collagen binding [GO:0005518]; myosin binding [GO:0017022]	basement membrane [GO:0005604]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; terminal bouton [GO:0043195]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0009887; GO:0009888; GO:0017022; GO:0032391; GO:0032420; GO:0035315; GO:0043025; GO:0043195; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060041; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018352	GN018352.1	Q8K3K1	41.1	304	304	5125	1.73e-67	231	USH2A_RAT	Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog)	Rattus norvegicus (Rat)	animal organ morphogenesis [GO:0009887]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; tissue development [GO:0009888]	collagen binding [GO:0005518]; myosin binding [GO:0017022]	basement membrane [GO:0005604]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; terminal bouton [GO:0043195]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0009887; GO:0009888; GO:0017022; GO:0032391; GO:0032420; GO:0035315; GO:0043025; GO:0043195; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060041; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018354	GN018354.1	Q8K3K1	42.4	295	295	5125	3.60e-70	239	USH2A_RAT	Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog)	Rattus norvegicus (Rat)	animal organ morphogenesis [GO:0009887]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; tissue development [GO:0009888]	collagen binding [GO:0005518]; myosin binding [GO:0017022]	basement membrane [GO:0005604]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; terminal bouton [GO:0043195]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0009887; GO:0009888; GO:0017022; GO:0032391; GO:0032420; GO:0035315; GO:0043025; GO:0043195; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060041; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018356	GN018356.1	Q8K3K1	41.1	304	304	5125	1.73e-67	231	USH2A_RAT	Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog)	Rattus norvegicus (Rat)	animal organ morphogenesis [GO:0009887]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; tissue development [GO:0009888]	collagen binding [GO:0005518]; myosin binding [GO:0017022]	basement membrane [GO:0005604]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; terminal bouton [GO:0043195]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0009887; GO:0009888; GO:0017022; GO:0032391; GO:0032420; GO:0035315; GO:0043025; GO:0043195; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060041; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018359	GN018359.1	Q8K3K1	40.1	406	455	5125	2.11e-88	298	USH2A_RAT	Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog)	Rattus norvegicus (Rat)	animal organ morphogenesis [GO:0009887]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; tissue development [GO:0009888]	collagen binding [GO:0005518]; myosin binding [GO:0017022]	basement membrane [GO:0005604]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; terminal bouton [GO:0043195]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0009887; GO:0009888; GO:0017022; GO:0032391; GO:0032420; GO:0035315; GO:0043025; GO:0043195; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060041; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018362	GN018362.1	Q2QI47	29.3	242	228	5193	3.58e-19	89.4	USH2A_MOUSE	Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; tissue development [GO:0009888]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; terminal bouton [GO:0043195]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0009887; GO:0009888; GO:0016324; GO:0017022; GO:0032391; GO:0032420; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0043025; GO:0043195; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018363	GN018363.1	O75445	38.4	617	616	5202	1.03e-127	418	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018364	GN018364.1	O75445	34.0	291	361	5202	4.33e-40	154	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018365	GN018365.1	O75445	30.9	349	377	5202	1.45e-47	177	USH2A_HUMAN	Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of animal organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]	collagen binding [GO:0005518]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]	apical plasma membrane [GO:0016324]; basement membrane [GO:0005604]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium bundle [GO:0032421]; stereocilium membrane [GO:0060171]; USH2 complex [GO:1990696]	GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007605; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042802; GO:0045184; GO:0045494; GO:0048496; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696
GN018369	GN018369.1	Q99NE9	46.9	49	62	378	2.18e-09	54.3	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN018370	GN018370.1	Q99NE9	43.3	60	113	378	4.51e-10	58.5	PBX4_MOUSE	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	Mus musculus (Mouse)	animal organ morphogenesis [GO:0009887]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; eye development [GO:0001654]; neuron development [GO:0048666]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	nucleus [GO:0005634]; XY body [GO:0001741]	GO:0000978; GO:0001228; GO:0001654; GO:0001741; GO:0005634; GO:0006357; GO:0007420; GO:0009887; GO:0043565; GO:0045893; GO:0045944; GO:0048568; GO:0048666
GN018371	GN018371.1	A5D8S0	28.7	202	455	706	5.72e-13	74.7	KIZ_DANRE	Centrosomal protein kizuna (Polo-like kinase 1 substrate 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	spindle organization [GO:0007051]		centrosome [GO:0005813]	GO:0005813; GO:0007051
GN018373	GN018373.1	Q9Y3B9	46.7	195	260	282	6.21e-33	124	RRP15_HUMAN	RRP15-like protein (Ribosomal RNA-processing protein 15)	Homo sapiens (Human)	maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]		preribosome, large subunit precursor [GO:0030687]	GO:0000460; GO:0000470; GO:0030687
GN018374	GN018374.1	Q9Y2R4	59.2	380	496	599	3.81e-155	457	DDX52_HUMAN	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.4.13) (ATP-dependent RNA helicase ROK1-like) (DEAD box protein 52)	Homo sapiens (Human)	maturation of SSU-rRNA [GO:0030490]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0003723; GO:0003724; GO:0005524; GO:0005654; GO:0005730; GO:0016020; GO:0016887; GO:0030490
GN018375	GN018375.1	Q0VC91	66.7	174	422	440	1.23e-79	255	SOCS4_BOVIN	Suppressor of cytokine signaling 4 (SOCS-4)	Bos taurus (Bovine)	cytokine-mediated signaling pathway [GO:0019221]; intracellular signal transduction [GO:0035556]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]			GO:0007175; GO:0016567; GO:0019221; GO:0032436; GO:0035556
GN018377	GN018377.1	Q1JQ99	50.8	126	131	145	5.31e-36	123	RM14_BOVIN	Large ribosomal subunit protein uL14m (39S ribosomal protein L14, mitochondrial) (L14mt) (MRP-L14)	Bos taurus (Bovine)	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005762; GO:0006412
GN018379	GN018379.1	P42674	32.4	401	414	597	2.52e-49	179	BP10_PARLI	Blastula protease 10 (EC 3.4.24.-)	Paracentrotus lividus (Common sea urchin)	molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]	GO:0004222; GO:0005576; GO:0005938; GO:0006508; GO:0008270; GO:0018996; GO:0048471
GN018380	GN018380.1	P42674	37.5	395	487	597	8.75e-70	236	BP10_PARLI	Blastula protease 10 (EC 3.4.24.-)	Paracentrotus lividus (Common sea urchin)	molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	cell cortex [GO:0005938]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]	GO:0004222; GO:0005576; GO:0005938; GO:0006508; GO:0008270; GO:0018996; GO:0048471
GN018381	GN018381.1	O93610	55.5	443	462	463	1.23e-170	490	DPOD2_XENLA	DNA polymerase delta subunit 2 (XlCdc1)	Xenopus laevis (African clawed frog)	DNA strand elongation involved in DNA replication [GO:0006271]	DNA binding [GO:0003677]	delta DNA polymerase complex [GO:0043625]; nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0006271; GO:0043625
GN018382	GN018382.1	Q567G6	28.0	182	721	525	1.88e-11	70.9	RMP64_DANRE	Nucleolus and neural progenitor protein	Danio rerio (Zebrafish) (Brachydanio rerio)	negative regulation of neuron differentiation [GO:0045665]; positive regulation of Notch signaling pathway [GO:0045747]; RNA processing [GO:0006396]		nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]	GO:0000172; GO:0005634; GO:0005730; GO:0006396; GO:0045665; GO:0045747
GN018383	GN018383.1	P14408	65.3	464	746	507	1.50e-204	589	FUMH_RAT	Fumarate hydratase, mitochondrial (Fumarase) (EC 4.2.1.2)	Rattus norvegicus (Rat)	arginine metabolic process [GO:0006525]; DNA damage response [GO:0006974]; fumarate metabolic process [GO:0006106]; malate metabolic process [GO:0006108]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; tricarboxylic acid cycle [GO:0006099]; urea cycle [GO:0000050]	fumarate hydratase activity [GO:0004333]; histone binding [GO:0042393]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000050; GO:0004333; GO:0005634; GO:0005694; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006099; GO:0006106; GO:0006108; GO:0006525; GO:0006974; GO:0035861; GO:0042393; GO:0120162; GO:2001034
GN018384	GN018384.1	Q0VAA2	40.7	91	603	488	2.94e-11	69.7	LR74A_HUMAN	Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74)	Homo sapiens (Human)				
GN018386	GN018386.1	Q32PA9	73.1	130	145	140	3.24e-61	187	FKBP2_BOVIN	Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (FK506-binding protein 2) (FKBP-2) (Rotamase)	Bos taurus (Bovine)		peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	endoplasmic reticulum membrane [GO:0005789]	GO:0003755; GO:0005789
GN018388	GN018388.1	Q568K5	51.7	120	141	237	2.97e-33	119	NAA40_DANRE	N-alpha-acetyltransferase 40 (EC 2.3.1.257) (N-acetyltransferase 11) (N-alpha-acetyltransferase D) (NatD)	Danio rerio (Zebrafish) (Brachydanio rerio)		histone H2A acetyltransferase activity [GO:0043998]; histone H4 acetyltransferase activity [GO:0010485]; protein N-terminal-serine acetyltransferase activity [GO:1990189]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0010485; GO:0043998; GO:1990189
GN018389	GN018389.1	Q6DFF9	53.7	708	1782	1580	1.45e-205	659	MABP1_XENLA	Mitogen-activated protein kinase-binding protein 1	Xenopus laevis (African clawed frog)	negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; positive regulation of JNK cascade [GO:0046330]; regulation of mitotic cell cycle [GO:0007346]		cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]	GO:0005737; GO:0007346; GO:0043124; GO:0046330; GO:0072686
GN018390	GN018390.1	Q9GZT9	31.3	316	304	426	2.09e-26	110	EGLN1_HUMAN	Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)	Homo sapiens (Human)	cellular response to hypoxia [GO:0071456]; intracellular iron ion homeostasis [GO:0006879]; intracellular oxygen homeostasis [GO:0032364]; negative regulation of hypoxia-inducible factor-1alpha signaling pathway [GO:1902072]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of angiogenesis [GO:0045765]; regulation of modification of postsynaptic structure [GO:0099159]; regulation of neuron apoptotic process [GO:0043523]; regulation protein catabolic process at postsynapse [GO:0140252]; response to hypoxia [GO:0001666]; response to nitric oxide [GO:0071731]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; ferrous iron binding [GO:0008198]; hypoxia-inducible factor-proline dioxygenase activity [GO:0160082]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545]; peptidyl-proline dioxygenase activity [GO:0031543]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	GO:0001666; GO:0004857; GO:0005634; GO:0005737; GO:0005829; GO:0006879; GO:0008198; GO:0014069; GO:0016706; GO:0019899; GO:0031418; GO:0031543; GO:0031545; GO:0032364; GO:0043523; GO:0045765; GO:0045944; GO:0071456; GO:0071731; GO:0098978; GO:0099159; GO:0140252; GO:0160082; GO:1902072
GN018391	GN018391.1	Q9H6Z9	71.4	105	391	239	5.59e-51	174	EGLN3_HUMAN	Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3)	Homo sapiens (Human)	cellular response to hypoxia [GO:0071456]; negative regulation of ferroptosis [GO:0110076]; protein hydroxylation [GO:0018126]; protein stabilization [GO:0050821]; regulation of neuron apoptotic process [GO:0043523]	2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; ferrous iron binding [GO:0008198]; hypoxia-inducible factor-proline dioxygenase activity [GO:0160082]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 4-dioxygenase activity [GO:0031545]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0008198; GO:0016706; GO:0018126; GO:0031418; GO:0031545; GO:0043523; GO:0050821; GO:0071456; GO:0110076; GO:0160082
GN018392	GN018392.1	Q07130	64.3	512	498	508	1.13e-213	603	UGPA_BOVIN	UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase)	Bos taurus (Bovine)	glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; UDP-alpha-D-glucose metabolic process [GO:0006011]	UTP:glucose-1-phosphate uridylyltransferase activity [GO:0003983]	cytoplasm [GO:0005737]	GO:0003983; GO:0005737; GO:0005977; GO:0005978; GO:0006011
GN018393	GN018393.1	Q86TJ2	45.7	440	438	420	1.76e-125	373	TAD2B_HUMAN	Transcriptional adapter 2-beta (ADA2-like protein beta) (ADA2-beta)	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA repair [GO:0006282]; regulation of RNA splicing [GO:0043484]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]; SAGA-type complex [GO:0070461]	GO:0000124; GO:0003682; GO:0003713; GO:0005654; GO:0006282; GO:0006338; GO:0006357; GO:0008270; GO:0043484; GO:0045893; GO:0070461
GN018394	GN018394.1	Q5ZME2	69.9	329	333	334	6.19e-157	445	MDHC_CHICK	Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Cytosolic malate dehydrogenase)	Gallus gallus (Chicken)	gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]	(S)-2-hydroxyglutarate dehydrogenase activity [GO:0047545]; L-malate dehydrogenase (NAD+) activity [GO:0030060]	cytosol [GO:0005829]; extracellular region [GO:0005576]	GO:0005576; GO:0005829; GO:0006094; GO:0006108; GO:0030060; GO:0047545
GN018395	GN018395.1	Q6P9U1	46.9	288	322	308	5.94e-73	230	NUD22_RAT	Uridine diphosphate glucose pyrophosphatase NUDT22 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 22) (Nudix motif 22)	Rattus norvegicus (Rat)		UDP-sugar diphosphatase activity [GO:0008768]	nucleoplasm [GO:0005654]	GO:0005654; GO:0008768
GN018396	GN018396.1	Q2KIU7	58.7	276	275	276	1.17e-111	326	RSPH9_BOVIN	Radial spoke head protein 9 homolog	Bos taurus (Bovine)	axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294]; motile cilium assembly [GO:0044458]		9+2 motile cilium [GO:0097729]; axoneme [GO:0005930]; kinocilium [GO:0060091]; radial spoke head [GO:0001535]; sperm flagellum [GO:0036126]	GO:0001535; GO:0005930; GO:0035082; GO:0036126; GO:0044458; GO:0060091; GO:0060294; GO:0097729
GN018406	GN018406.1	Q14191	30.5	439	461	1432	1.56e-39	155	WRN_HUMAN	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Homo sapiens (Human)	base-excision repair [GO:0006284]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; mismatch repair [GO:0006298]; positive regulation of strand invasion [GO:0098530]; protein localization to nucleolus [GO:1902570]; replication fork processing [GO:0031297]; response to UV-C [GO:0010225]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; 3'-flap-structured DNA binding [GO:0070337]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bubble DNA binding [GO:0000405]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; exonuclease activity [GO:0004527]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MutLalpha complex binding [GO:0032405]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]	centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000287; GO:0000400; GO:0000403; GO:0000405; GO:0000723; GO:0000731; GO:0000781; GO:0003677; GO:0003678; GO:0004527; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005730; GO:0005737; GO:0005813; GO:0006259; GO:0006260; GO:0006284; GO:0006298; GO:0006302; GO:0006310; GO:0006974; GO:0008408; GO:0009267; GO:0009378; GO:0010225; GO:0016607; GO:0016887; GO:0030145; GO:0031297; GO:0032201; GO:0032392; GO:0032405; GO:0042803; GO:0043138; GO:0044877; GO:0051880; GO:0061749; GO:0061820; GO:0061821; GO:0061849; GO:0070337; GO:0071480; GO:0090398; GO:0090656; GO:0098530; GO:1902570; GO:1905773
GN018412	GN018412.1	Q9P6I3	26.8	209	461	442	1.48e-10	66.6	YHG7_SCHPO	Putative mannan endo-1,6-alpha-mannosidase C1198.07c (EC 3.2.1.101) (Endo-alpha-1->6-D-mannanase C1198.07c)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	carbohydrate catabolic process [GO:0016052]; fungal-type cell wall biogenesis [GO:0009272]; septum digestion after cytokinesis [GO:0000920]	mannan endo-1,6-alpha-mannosidase activity [GO:0008496]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]	GO:0000920; GO:0005783; GO:0005789; GO:0008496; GO:0009272; GO:0009897; GO:0016052
GN018413	GN018413.1	Q9P6I3	26.8	209	458	442	1.46e-10	66.6	YHG7_SCHPO	Putative mannan endo-1,6-alpha-mannosidase C1198.07c (EC 3.2.1.101) (Endo-alpha-1->6-D-mannanase C1198.07c)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	carbohydrate catabolic process [GO:0016052]; fungal-type cell wall biogenesis [GO:0009272]; septum digestion after cytokinesis [GO:0000920]	mannan endo-1,6-alpha-mannosidase activity [GO:0008496]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]	GO:0000920; GO:0005783; GO:0005789; GO:0008496; GO:0009272; GO:0009897; GO:0016052
GN018414	GN018414.1	O35379	36.5	772	740	1528	3.47e-145	465	MRP1_MOUSE	ATP-binding cassette sub-family C member 1 (EC 7.6.2.-) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) (Multidrug resistance-associated protein 1) (EC 7.6.2.2)	Mus musculus (Mouse)	amygdala development [GO:0021764]; amyloid-beta clearance [GO:0097242]; amyloid-beta metabolic process [GO:0050435]; antigen processing and presentation of lipid antigen via MHC class Ib [GO:0048003]; apoptotic process [GO:0006915]; astrocyte differentiation [GO:0048708]; bilirubin transport [GO:0015723]; blood vessel diameter maintenance [GO:0097746]; carboxylic acid transmembrane transport [GO:1905039]; cell chemotaxis [GO:0060326]; cell redox homeostasis [GO:0045454]; cellular response to amyloid-beta [GO:1904646]; cellular response to type II interferon [GO:0071346]; cobalamin transport [GO:0015889]; cyclic nucleotide transport [GO:0070729]; defense response to Gram-positive bacterium [GO:0050830]; DNA damage response [GO:0006974]; endothelial cell apoptotic process [GO:0072577]; endothelium development [GO:0003158]; exploration behavior [GO:0035640]; export across plasma membrane [GO:0140115]; export from cell [GO:0140352]; fibroblast apoptotic process [GO:0044346]; gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; glucocorticoid metabolic process [GO:0008211]; glutathione metabolic process [GO:0006749]; glutathione transmembrane transport [GO:0034775]; glutathione transport [GO:0034635]; granuloma formation [GO:0002432]; hippocampus development [GO:0021766]; hydrogen peroxide biosynthetic process [GO:0050665]; immune response [GO:0006955]; inflammatory response [GO:0006954]; inflammatory response to antigenic stimulus [GO:0002437]; intracellular chemical homeostasis [GO:0055082]; intracellular nitrogen homeostasis [GO:0141067]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; long-chain fatty acid import across plasma membrane [GO:0015911]; lymphocyte migration [GO:0072676]; macrophage activation [GO:0042116]; memory [GO:0007613]; multicellular organism growth [GO:0035264]; neural tissue regeneration [GO:0097719]; neurogenesis [GO:0022008]; NK T cell activation [GO:0051132]; phospholipid efflux [GO:0033700]; phospholipid translocation [GO:0045332]; pigment accumulation [GO:0043476]; positive regulation of cell migration [GO:0030335]; positive regulation of inflammatory response [GO:0050729]; protein localization to cell surface [GO:0034394]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of catalytic activity [GO:0050790]; regulation of cellular response to drug [GO:2001038]; regulation of membrane potential [GO:0042391]; response to fluid shear stress [GO:0034405]; response to glucocorticoid [GO:0051384]; response to oxidative stress [GO:0006979]; response to toxic substance [GO:0009636]; response to type II interferon [GO:0034341]; response to xenobiotic stimulus [GO:0009410]; sphingolipid translocation [GO:0099039]; superoxide anion generation [GO:0042554]; tetrahydrobiopterin metabolic process [GO:0046146]; tissue homeostasis [GO:0001894]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; vasodilation [GO:0042311]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type vitamin B12 transporter activity [GO:0015420]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; carboxylic acid transmembrane transporter activity [GO:0046943]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	GO:0001894; GO:0002432; GO:0002437; GO:0003158; GO:0005324; GO:0005524; GO:0005886; GO:0006691; GO:0006749; GO:0006855; GO:0006915; GO:0006954; GO:0006955; GO:0006974; GO:0006979; GO:0007613; GO:0008211; GO:0008559; GO:0009410; GO:0009636; GO:0009925; GO:0010001; GO:0010467; GO:0015420; GO:0015431; GO:0015562; GO:0015723; GO:0015889; GO:0015911; GO:0016323; GO:0016324; GO:0016328; GO:0016887; GO:0019370; GO:0021764; GO:0021766; GO:0022008; GO:0022857; GO:0030054; GO:0030335; GO:0033700; GO:0034040; GO:0034341; GO:0034394; GO:0034405; GO:0034634; GO:0034635; GO:0034775; GO:0035264; GO:0035640; GO:0042116; GO:0042311; GO:0042391; GO:0042554; GO:0042908; GO:0042910; GO:0043476; GO:0044346; GO:0045332; GO:0045454; GO:0046146; GO:0046943; GO:0048003; GO:0048708; GO:0050435; GO:0050665; GO:0050729; GO:0050790; GO:0050830; GO:0051132; GO:0051384; GO:0055082; GO:0055085; GO:0060326; GO:0070633; GO:0070729; GO:0071346; GO:0071716; GO:0072577; GO:0072676; GO:0097242; GO:0097719; GO:0097746; GO:0099039; GO:0140115; GO:0140352; GO:0140359; GO:0141067; GO:1903409; GO:1904646; GO:1905039; GO:1990961; GO:1990962; GO:2001038
GN018415	GN018415.1	O35379	63.3	335	339	1528	4.07e-136	424	MRP1_MOUSE	ATP-binding cassette sub-family C member 1 (EC 7.6.2.-) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) (Multidrug resistance-associated protein 1) (EC 7.6.2.2)	Mus musculus (Mouse)	amygdala development [GO:0021764]; amyloid-beta clearance [GO:0097242]; amyloid-beta metabolic process [GO:0050435]; antigen processing and presentation of lipid antigen via MHC class Ib [GO:0048003]; apoptotic process [GO:0006915]; astrocyte differentiation [GO:0048708]; bilirubin transport [GO:0015723]; blood vessel diameter maintenance [GO:0097746]; carboxylic acid transmembrane transport [GO:1905039]; cell chemotaxis [GO:0060326]; cell redox homeostasis [GO:0045454]; cellular response to amyloid-beta [GO:1904646]; cellular response to type II interferon [GO:0071346]; cobalamin transport [GO:0015889]; cyclic nucleotide transport [GO:0070729]; defense response to Gram-positive bacterium [GO:0050830]; DNA damage response [GO:0006974]; endothelial cell apoptotic process [GO:0072577]; endothelium development [GO:0003158]; exploration behavior [GO:0035640]; export across plasma membrane [GO:0140115]; export from cell [GO:0140352]; fibroblast apoptotic process [GO:0044346]; gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; glucocorticoid metabolic process [GO:0008211]; glutathione metabolic process [GO:0006749]; glutathione transmembrane transport [GO:0034775]; glutathione transport [GO:0034635]; granuloma formation [GO:0002432]; hippocampus development [GO:0021766]; hydrogen peroxide biosynthetic process [GO:0050665]; immune response [GO:0006955]; inflammatory response [GO:0006954]; inflammatory response to antigenic stimulus [GO:0002437]; intracellular chemical homeostasis [GO:0055082]; intracellular nitrogen homeostasis [GO:0141067]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; long-chain fatty acid import across plasma membrane [GO:0015911]; lymphocyte migration [GO:0072676]; macrophage activation [GO:0042116]; memory [GO:0007613]; multicellular organism growth [GO:0035264]; neural tissue regeneration [GO:0097719]; neurogenesis [GO:0022008]; NK T cell activation [GO:0051132]; phospholipid efflux [GO:0033700]; phospholipid translocation [GO:0045332]; pigment accumulation [GO:0043476]; positive regulation of cell migration [GO:0030335]; positive regulation of inflammatory response [GO:0050729]; protein localization to cell surface [GO:0034394]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of catalytic activity [GO:0050790]; regulation of cellular response to drug [GO:2001038]; regulation of membrane potential [GO:0042391]; response to fluid shear stress [GO:0034405]; response to glucocorticoid [GO:0051384]; response to oxidative stress [GO:0006979]; response to toxic substance [GO:0009636]; response to type II interferon [GO:0034341]; response to xenobiotic stimulus [GO:0009410]; sphingolipid translocation [GO:0099039]; superoxide anion generation [GO:0042554]; tetrahydrobiopterin metabolic process [GO:0046146]; tissue homeostasis [GO:0001894]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; vasodilation [GO:0042311]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type vitamin B12 transporter activity [GO:0015420]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; carboxylic acid transmembrane transporter activity [GO:0046943]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	GO:0001894; GO:0002432; GO:0002437; GO:0003158; GO:0005324; GO:0005524; GO:0005886; GO:0006691; GO:0006749; GO:0006855; GO:0006915; GO:0006954; GO:0006955; GO:0006974; GO:0006979; GO:0007613; GO:0008211; GO:0008559; GO:0009410; GO:0009636; GO:0009925; GO:0010001; GO:0010467; GO:0015420; GO:0015431; GO:0015562; GO:0015723; GO:0015889; GO:0015911; GO:0016323; GO:0016324; GO:0016328; GO:0016887; GO:0019370; GO:0021764; GO:0021766; GO:0022008; GO:0022857; GO:0030054; GO:0030335; GO:0033700; GO:0034040; GO:0034341; GO:0034394; GO:0034405; GO:0034634; GO:0034635; GO:0034775; GO:0035264; GO:0035640; GO:0042116; GO:0042311; GO:0042391; GO:0042554; GO:0042908; GO:0042910; GO:0043476; GO:0044346; GO:0045332; GO:0045454; GO:0046146; GO:0046943; GO:0048003; GO:0048708; GO:0050435; GO:0050665; GO:0050729; GO:0050790; GO:0050830; GO:0051132; GO:0051384; GO:0055082; GO:0055085; GO:0060326; GO:0070633; GO:0070729; GO:0071346; GO:0071716; GO:0072577; GO:0072676; GO:0097242; GO:0097719; GO:0097746; GO:0099039; GO:0140115; GO:0140352; GO:0140359; GO:0141067; GO:1903409; GO:1904646; GO:1905039; GO:1990961; GO:1990962; GO:2001038
GN018416	GN018416.1	O88563	42.2	372	372	1522	1.52e-86	289	MRP3_RAT	ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (MRP-like protein 2) (MLP-2) (Multidrug resistance-associated protein 3)	Rattus norvegicus (Rat)	bile acid and bile salt transport [GO:0015721]; canalicular bile acid transport [GO:0015722]; leukotriene transport [GO:0071716]; monoatomic anion transmembrane transport [GO:0098656]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; response to tetrachloromethane [GO:1904772]; transmembrane transport [GO:0055085]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	ABC-type bile acid transporter activity [GO:0015432]; ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; glucuronoside transmembrane transporter activity [GO:0015164]; icosanoid transmembrane transporter activity [GO:0071714]; xenobiotic transmembrane transporter activity [GO:0042910]	basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005524; GO:0005886; GO:0006855; GO:0008559; GO:0009925; GO:0015164; GO:0015431; GO:0015432; GO:0015721; GO:0015722; GO:0016323; GO:0016887; GO:0032355; GO:0032496; GO:0042626; GO:0042908; GO:0042910; GO:0055085; GO:0071714; GO:0071716; GO:0098656; GO:1904772
GN018417	GN018417.1	A0A0R3K2G2	26.1	357	412	480	3.40e-41	155	GLPDH_CALMK	Glycerol 3-phosphate dehydrogenase (EC 1.1.99.-)	Caloramator mitchellensis	glycerol catabolic process [GO:0019563]			GO:0019563
GN018419	GN018419.1	Q8K4Q6	52.7	150	148	389	7.11e-44	151	NEIL1_MOUSE	Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (Nei homolog 1) (NEH1) (Nei-like protein 1)	Mus musculus (Mouse)	base-excision repair [GO:0006284]; DNA repair [GO:0006281]; response to oxidative stress [GO:0006979]	class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; lyase activity [GO:0016829]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003684; GO:0003906; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005813; GO:0006281; GO:0006284; GO:0006979; GO:0008270; GO:0016798; GO:0016829; GO:0019104; GO:0140078
GN018420	GN018420.1	A0A345BJN8	31.0	248	606	919	1.74e-24	112	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN018422	GN018422.1	A2XJR0	29.5	241	860	540	6.28e-22	104	RG454_ORYSI	Ring-type E3 ubiquitin ligase 454 (OsRING454) (RBR-type E3 ubiquitin transferase) (OsRBRL) (EC 2.3.2.31)	Oryza sativa subsp. indica (Rice)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN018425	GN018425.1	A2XJR0	29.9	241	860	540	2.67e-22	105	RG454_ORYSI	Ring-type E3 ubiquitin ligase 454 (OsRING454) (RBR-type E3 ubiquitin transferase) (OsRBRL) (EC 2.3.2.31)	Oryza sativa subsp. indica (Rice)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN018428	GN018428.1	A2XJR0	29.9	241	896	540	2.87e-22	105	RG454_ORYSI	Ring-type E3 ubiquitin ligase 454 (OsRING454) (RBR-type E3 ubiquitin transferase) (OsRBRL) (EC 2.3.2.31)	Oryza sativa subsp. indica (Rice)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN018429	GN018429.1	Q949V6	27.1	240	441	597	4.87e-19	93.2	ARI1_ARATH	Probable E3 ubiquitin-protein ligase ARI1 (EC 2.3.2.31) (ARIADNE-like protein ARI1) (Protein ariadne homolog 1) (RING-type E3 ubiquitin transferase ARI1)	Arabidopsis thaliana (Mouse-ear cress)	protein ubiquitination [GO:0016567]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005737; GO:0008270; GO:0016567; GO:0031624; GO:0061630
GN018434	GN018434.1	P55013	61.3	62	100	1191	1.10e-19	85.5	S12A2_SQUAC	Solute carrier family 12 member 2 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (NKCC1) (Na-K-CL symporter)	Squalus acanthias (Spiny dogfish)	cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; inorganic cation import across plasma membrane [GO:0098659]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; sodium ion homeostasis [GO:0055078]	ammonium channel activity [GO:0008519]; metal ion transmembrane transporter activity [GO:0046873]; sodium:potassium:chloride symporter activity [GO:0008511]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]	GO:0006884; GO:0008511; GO:0008519; GO:0016323; GO:0016324; GO:0046873; GO:0055064; GO:0055075; GO:0055078; GO:0071944; GO:0098659; GO:1990573
GN018444	GN018444.1	Q58DU5	72.9	255	255	255	7.69e-133	378	PSA3_BOVIN	Proteasome subunit alpha type-3	Bos taurus (Bovine)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]	GO:0005634; GO:0005737; GO:0005829; GO:0005839; GO:0019773; GO:0043161
GN018445	GN018445.1	Q5REV9	51.3	597	585	689	1.75e-189	551	NPT2B_PONAB	Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transport [GO:0006817]; sodium-dependent phosphate transport [GO:0044341]	phosphate ion binding [GO:0042301]; sodium ion binding [GO:0031402]; sodium:phosphate symporter activity [GO:0005436]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; membrane [GO:0016020]; vesicle [GO:0031982]	GO:0005436; GO:0005903; GO:0006817; GO:0016020; GO:0016324; GO:0030643; GO:0031402; GO:0031982; GO:0042301; GO:0044341
GN018446	GN018446.1	Q5REV9	53.3	555	667	689	4.88e-187	548	NPT2B_PONAB	Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transport [GO:0006817]; sodium-dependent phosphate transport [GO:0044341]	phosphate ion binding [GO:0042301]; sodium ion binding [GO:0031402]; sodium:phosphate symporter activity [GO:0005436]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; membrane [GO:0016020]; vesicle [GO:0031982]	GO:0005436; GO:0005903; GO:0006817; GO:0016020; GO:0016324; GO:0030643; GO:0031402; GO:0031982; GO:0042301; GO:0044341
GN018447	GN018447.1	Q5REV9	55.1	559	585	689	3.36e-192	558	NPT2B_PONAB	Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	intracellular phosphate ion homeostasis [GO:0030643]; phosphate ion transport [GO:0006817]; sodium-dependent phosphate transport [GO:0044341]	phosphate ion binding [GO:0042301]; sodium ion binding [GO:0031402]; sodium:phosphate symporter activity [GO:0005436]	apical plasma membrane [GO:0016324]; brush border [GO:0005903]; membrane [GO:0016020]; vesicle [GO:0031982]	GO:0005436; GO:0005903; GO:0006817; GO:0016020; GO:0016324; GO:0030643; GO:0031402; GO:0031982; GO:0042301; GO:0044341
GN018448	GN018448.1	F1QMV3	67.3	150	155	157	3.04e-70	211	TPC6B_DANRE	Trafficking protein particle complex subunit 6b (TRAPP complex subunit 6B)	Danio rerio (Zebrafish) (Brachydanio rerio)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]		cis-Golgi network [GO:0005801]; endoplasmic reticulum [GO:0005783]; trans-Golgi network [GO:0005802]	GO:0005783; GO:0005801; GO:0005802; GO:0006888
GN018449	GN018449.1	Q9H307	33.7	282	485	717	6.34e-31	130	PININ_HUMAN	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein)	Homo sapiens (Human)	cell adhesion [GO:0007155]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; positive regulation of apoptotic process [GO:0043065]; regulation of mRNA processing [GO:0050684]	RNA binding [GO:0003723]; structural molecule activity [GO:0005198]	catalytic step 2 spliceosome [GO:0071013]; cell-cell junction [GO:0005911]; desmosome [GO:0030057]; intermediate filament [GO:0005882]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000398; GO:0003723; GO:0005198; GO:0005634; GO:0005654; GO:0005882; GO:0005886; GO:0005911; GO:0007155; GO:0016020; GO:0016607; GO:0030057; GO:0043065; GO:0048255; GO:0050684; GO:0071013
GN018450	GN018450.1	O15315	52.7	224	243	384	2.25e-71	226	RA51B_HUMAN	DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1)	Homo sapiens (Human)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; supramolecular fiber organization [GO:0097435]	ATP binding [GO:0005524]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent DNA damage sensor activity [GO:0140664]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]	GO:0000724; GO:0003677; GO:0003690; GO:0003697; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0006281; GO:0006310; GO:0007131; GO:0008094; GO:0010971; GO:0033063; GO:0097435; GO:0140664
GN018451	GN018451.1	D3YXS5	41.8	1044	1018	1028	1.18e-238	706	KIF28_MOUSE	Kinesin-like protein KIF28 (Kinesin family member 28) (Kinesin-like protein 6)	Mus musculus (Mouse)	mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384]; vesicle transport along microtubule [GO:0047496]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	kinesin complex [GO:0005871]; mitochondrial membrane [GO:0031966]	GO:0003777; GO:0005524; GO:0005871; GO:0007005; GO:0008017; GO:0031966; GO:0047496; GO:0072384
GN018455	GN018455.1	Q80UC8	26.3	285	402	345	4.12e-11	67.4	GP139_MOUSE	Probable G protein-coupled receptor 139 (G protein-coupled receptor PGR3) (G(q)-coupled orphan receptor GPRg1)	Mus musculus (Mouse)	G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]	G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; neuropeptide receptor activity [GO:0008188]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007186; GO:0007200; GO:0008188; GO:0042802
GN018466	GN018466.1	Q5ZI27	45.6	68	194	330	4.69e-09	58.2	NAIF1_CHICK	Nuclear apoptosis-inducing factor 1	Gallus gallus (Chicken)	homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705]; oogenesis [GO:0048477]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]; spermatogenesis [GO:0007283]		central element [GO:0000801]; nucleus [GO:0005634]	GO:0000801; GO:0005634; GO:0007129; GO:0007283; GO:0010705; GO:0048477; GO:1902108
GN018471	GN018471.1	Q8IY51	35.5	217	235	512	4.59e-40	147	TIGD4_HUMAN	Tigger transposable element-derived protein 4	Homo sapiens (Human)		DNA binding [GO:0003677]	nucleus [GO:0005634]	GO:0003677; GO:0005634
GN018472	GN018472.1	P54131	40.6	320	775	499	1.11e-79	267	ACHA7_BOVIN	Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7)	Bos taurus (Bovine)	calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; regulation of membrane potential [GO:0042391]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; neurotransmitter receptor activity [GO:0030594]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]	acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001540; GO:0001666; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0030425; GO:0030594; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042391; GO:0042803; GO:0043005; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890; GO:1900016
GN018473	GN018473.1	Q6DEL2	60.4	560	631	631	1.42e-252	712	CLPT1_DANRE	Putative lipid scramblase CLPTM1 (Cleft lip and palate transmembrane protein 1 homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)			endomembrane system [GO:0012505]; membrane [GO:0016020]	GO:0012505; GO:0016020
GN018474	GN018474.1	Q9WVR8	54.0	457	719	610	2.79e-159	476	MEN1_RAT	Menin	Rattus norvegicus (Rat)	cellular response to glucose stimulus [GO:0071333]; cellular response to peptide hormone stimulus [GO:0071375]; chromatin remodeling [GO:0006338]; decidualization [GO:0046697]; DNA damage response [GO:0006974]; embryonic skeletal system morphogenesis [GO:0048704]; hemopoiesis [GO:0030097]; leukocyte homeostasis [GO:0001776]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of JNK cascade [GO:0046329]; negative regulation of organ growth [GO:0046621]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ossification [GO:0001503]; osteoblast development [GO:0002076]; osteoblast fate commitment [GO:0002051]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell division [GO:0051781]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of activin receptor signaling pathway [GO:0032925]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to gamma radiation [GO:0010332]; response to transforming growth factor beta [GO:0071559]; response to UV [GO:0009411]; roof of mouth development [GO:0060021]; T-helper 2 cell differentiation [GO:0045064]; transcription initiation-coupled chromatin remodeling [GO:0045815]; type B pancreatic cell differentiation [GO:0003309]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; double-stranded DNA binding [GO:0003690]; four-way junction DNA binding [GO:0000400]; phosphoprotein binding [GO:0051219]; protein-macromolecule adaptor activity [GO:0030674]; R-SMAD binding [GO:0070412]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; Y-form DNA binding [GO:0000403]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone methyltransferase complex [GO:0035097]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000122; GO:0000400; GO:0000403; GO:0000781; GO:0000785; GO:0000976; GO:0001216; GO:0001503; GO:0001776; GO:0002051; GO:0002076; GO:0003309; GO:0003677; GO:0003682; GO:0003690; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006338; GO:0006357; GO:0006974; GO:0008285; GO:0009411; GO:0010332; GO:0010468; GO:0010628; GO:0010812; GO:0016363; GO:0030097; GO:0030511; GO:0030674; GO:0032154; GO:0032925; GO:0032991; GO:0035097; GO:0043065; GO:0043565; GO:0045064; GO:0045597; GO:0045668; GO:0045669; GO:0045786; GO:0045815; GO:0045892; GO:0045893; GO:0045944; GO:0046329; GO:0046621; GO:0046697; GO:0048704; GO:0050680; GO:0051219; GO:0051781; GO:0060021; GO:0060135; GO:0061469; GO:0070412; GO:0071333; GO:0071375; GO:0071559; GO:1902807; GO:2000045
GN018475	GN018475.1	Q5FVJ6	50.8	132	236	377	1.54e-38	140	BSCL2_RAT	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog)	Rattus norvegicus (Rat)	adipose tissue development [GO:0060612]; cytosolic lipolysis [GO:0061725]; fat cell differentiation [GO:0045444]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; negative regulation of catalytic activity [GO:0043086]; negative regulation of lipid catabolic process [GO:0050995]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of phosphatidic acid biosynthetic process [GO:1905693]; spermatid differentiation [GO:0048515]	phospholipid binding [GO:0005543]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]	GO:0005543; GO:0005783; GO:0005789; GO:0005811; GO:0005829; GO:0019915; GO:0034389; GO:0043086; GO:0045444; GO:0048515; GO:0050995; GO:0060612; GO:0061725; GO:0120162; GO:0140042; GO:1905693
GN018476	GN018476.1	Q9BWT3	60.8	518	730	736	2.07e-220	638	PAPOG_HUMAN	Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme)	Homo sapiens (Human)	co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway [GO:0180010]	metal ion binding [GO:0046872]; poly(A) RNA polymerase activity [GO:1990817]; RNA binding [GO:0003723]	cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005654; GO:0005829; GO:0016020; GO:0016604; GO:0046872; GO:0180010; GO:1990817
GN018477	GN018477.1	B7QK46	49.4	158	218	353	6.02e-42	148	QPCT_IXOSC	Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (Glutaminyl-tRNA cyclotransferase)	Ixodes scapularis (Black-legged tick) (Deer tick)	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase [GO:0017186]	glutaminyl-peptide cyclotransferase activity [GO:0016603]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0005576; GO:0008270; GO:0016603; GO:0017186
GN018478	GN018478.1	P11831	44.2	378	410	508	1.42e-65	220	SRF_HUMAN	Serum response factor (SRF)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; angiogenesis involved in wound healing [GO:0060055]; cardiac muscle cell myoblast differentiation [GO:0060379]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to glucose stimulus [GO:0071333]; cellular senescence [GO:0090398]; heart development [GO:0007507]; heart looping [GO:0001947]; long-term memory [GO:0007616]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of amyloid-beta clearance [GO:1900222]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of miRNA transcription [GO:1902894]; neuron development [GO:0048666]; positive regulation of cell differentiation [GO:0045597]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by glucose [GO:0046016]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of smooth muscle cell differentiation [GO:0051150]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; trophectodermal cell differentiation [GO:0001829]	chromatin DNA binding [GO:0031490]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; sequence-specific double-stranded DNA binding [GO:1990837]; serum response element binding [GO:0010736]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0001666; GO:0001829; GO:0001947; GO:0002042; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0007507; GO:0007616; GO:0008285; GO:0009636; GO:0009725; GO:0010736; GO:0030036; GO:0030336; GO:0031490; GO:0034097; GO:0042803; GO:0042826; GO:0045597; GO:0045944; GO:0045987; GO:0046016; GO:0046716; GO:0048666; GO:0051150; GO:0060055; GO:0060261; GO:0060379; GO:0061629; GO:0070878; GO:0071333; GO:0090398; GO:0140297; GO:1900222; GO:1902894; GO:1902895; GO:1990837
GN018483	GN018483.1	Q2KI79	40.3	119	253	313	1.91e-13	72.0	ANRA2_BOVIN	Ankyrin repeat family A protein 2	Bos taurus (Bovine)	regulation of gene expression [GO:0010468]; regulation of protein-containing complex assembly [GO:0043254]	histone deacetylase binding [GO:0042826]; low-density lipoprotein particle receptor binding [GO:0050750]; protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625]	3M complex [GO:1990393]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005829; GO:0005856; GO:0005886; GO:0010468; GO:0016020; GO:0019901; GO:0031625; GO:0042826; GO:0043254; GO:0050750; GO:1990393
GN018484	GN018484.1	D3YZI9	33.1	121	235	523	3.87e-09	59.7	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN018485	GN018485.1	Q6P4F7	38.5	252	1237	1023	1.26e-34	147	RHGBA_HUMAN	Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A)	Homo sapiens (Human)	positive regulation of GTPase activity [GO:0043547]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]	GTPase activator activity [GO:0005096]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005096; GO:0005634; GO:0005829; GO:0007165; GO:0043547; GO:0051056
GN018488	GN018488.1	Q9CQ46	61.3	163	163	164	7.44e-70	211	DRC8_MOUSE	Dynein regulatory complex protein 8 (EF-hand calcium-binding domain-containing protein 2)	Mus musculus (Mouse)		calcium ion binding [GO:0005509]	sperm principal piece [GO:0097228]	GO:0005509; GO:0097228
GN018490	GN018490.1	O97562	53.2	280	315	309	2.23e-95	287	UCP2_PIG	Dicarboxylate carrier UCP2 (Mitochondrial uncoupling protein 2) (UCP 2) (Solute carrier family 25 member 8)	Sus scrofa (Pig)	adaptive thermogenesis [GO:1990845]; C4-dicarboxylate transport [GO:0015740]; cellular response to glucose stimulus [GO:0071333]; glycolytic process [GO:0006096]; L-glutamine metabolic process [GO:0006541]; macrophage differentiation [GO:0030225]; mitochondrial fission [GO:0000266]; mitochondrial transmembrane transport [GO:1990542]; positive regulation of cold-induced thermogenesis [GO:0120162]; reactive oxygen species metabolic process [GO:0072593]; response to cold [GO:0009409]	antiporter activity [GO:0015297]; L-aspartate transmembrane transporter activity [GO:0015183]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; phosphate ion uniporter activity [GO:0140787]; protein homodimerization activity [GO:0042803]; proton transmembrane transporter activity [GO:0015078]; secondary active sulfate transmembrane transporter activity [GO:0008271]	mitochondrial inner membrane [GO:0005743]	GO:0000266; GO:0005324; GO:0005743; GO:0006096; GO:0006541; GO:0008271; GO:0009409; GO:0015078; GO:0015131; GO:0015140; GO:0015183; GO:0015297; GO:0015740; GO:0030225; GO:0042803; GO:0071333; GO:0072593; GO:0120162; GO:0140787; GO:1990542; GO:1990845
GN018491	GN018491.1	P04464	43.4	136	144	149	7.86e-27	100	CALM_WHEAT	Calmodulin (CaM)	Triticum aestivum (Wheat)		calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]	GO:0005509; GO:0005737; GO:0019904; GO:0030234
GN018492	GN018492.1	P78504	61.2	1187	1236	1218	4.79e-112	383	JAG1_HUMAN	Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)	Homo sapiens (Human)	angiogenesis [GO:0001525]; aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cell fate determination [GO:0001709]; distal tubule development [GO:0072017]; endocardial cushion cell development [GO:0061444]; endothelial cell differentiation [GO:0045446]; hemopoiesis [GO:0030097]; inner ear development [GO:0048839]; keratinocyte differentiation [GO:0030216]; loop of Henle development [GO:0072070]; myoblast differentiation [GO:0045445]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of stem cell differentiation [GO:2000737]; nephron development [GO:0072006]; nervous system development [GO:0007399]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; podocyte development [GO:0072015]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of cell population proliferation [GO:0042127]; response to muramyl dipeptide [GO:0032495]; T cell mediated immunity [GO:0002456]	calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; molecular adaptor activity [GO:0060090]; Notch binding [GO:0005112]; phospholipid binding [GO:0005543]; structural molecule activity [GO:0005198]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001525; GO:0001709; GO:0001953; GO:0002456; GO:0003180; GO:0003184; GO:0003215; GO:0005112; GO:0005198; GO:0005509; GO:0005543; GO:0005576; GO:0005886; GO:0005912; GO:0007219; GO:0007399; GO:0008083; GO:0016020; GO:0016324; GO:0022408; GO:0030097; GO:0030216; GO:0030336; GO:0032495; GO:0035909; GO:0042127; GO:0045445; GO:0045446; GO:0045602; GO:0045747; GO:0045944; GO:0048839; GO:0060090; GO:0060411; GO:0061156; GO:0061309; GO:0061444; GO:0062043; GO:0072006; GO:0072015; GO:0072017; GO:0072070; GO:0097150; GO:2000737
GN018493	GN018493.1	Q0II25	55.2	125	158	140	1.22e-40	136	POP7_BOVIN	Ribonuclease P protein subunit p20 (RNaseP protein p20)	Bos taurus (Bovine)	tRNA 5'-leader removal [GO:0001682]; tRNA processing [GO:0008033]	ribonuclease P RNA binding [GO:0033204]	cytoplasm [GO:0005737]; multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]	GO:0000172; GO:0001682; GO:0005634; GO:0005655; GO:0005730; GO:0005737; GO:0008033; GO:0030681; GO:0033204
GN018494	GN018494.1	A2RRH5	33.7	878	888	827	6.18e-145	452	WDR27_HUMAN	WD repeat-containing protein 27	Homo sapiens (Human)			nucleoplasm [GO:0005654]	GO:0005654
GN018495	GN018495.1	A1L2P2	53.8	80	90	91	1.75e-15	68.2	SI12A_XENLA	Small integral membrane protein 12-A	Xenopus laevis (African clawed frog)			membrane [GO:0016020]	GO:0016020
GN018496	GN018496.1	Q59E04	41.4	145	196	276	1.07e-24	100	7B2_DROME	Neuroendocrine protein 7B2	Drosophila melanogaster (Fruit fly)	neuropeptide signaling pathway [GO:0007218]; positive regulation of proteolysis [GO:0045862]; regulation of hormone secretion [GO:0046883]	enzyme regulator activity [GO:0030234]; peptidase activator activity [GO:0016504]	extracellular region [GO:0005576]; secretory granule [GO:0030141]	GO:0005576; GO:0007218; GO:0016504; GO:0030141; GO:0030234; GO:0045862; GO:0046883
GN018501	GN018501.1	Q29081	52.7	182	198	192	4.77e-62	194	PMVK_PIG	Phosphomevalonate kinase (PMKase) (EC 2.7.4.2)	Sus scrofa (Pig)	cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; farnesyl diphosphate biosynthetic process, mevalonate pathway [GO:0010142]; geranylgeranyl diphosphate biosynthetic process [GO:0033386]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; response to cholesterol [GO:0070723]; zymosterol biosynthetic process [GO:0036197]	ATP binding [GO:0005524]; phosphomevalonate kinase activity [GO:0004631]	cytosol [GO:0005829]	GO:0004631; GO:0005524; GO:0005829; GO:0006695; GO:0010142; GO:0019287; GO:0033386; GO:0033489; GO:0033490; GO:0036197; GO:0070723
GN018502	GN018502.1	Q3TX08	48.5	567	558	663	1.37e-177	519	TRM1_MOUSE	tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase)	Mus musculus (Mouse)	tRNA N2-guanine methylation [GO:0002940]	metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA (guanine(26)-N2)-dimethyltransferase activity [GO:0160104]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0002940; GO:0003723; GO:0005634; GO:0005737; GO:0005739; GO:0046872; GO:0160104
GN018504	GN018504.1	Q6PD74	33.3	348	383	315	4.40e-48	168	AAGAB_HUMAN	Alpha- and gamma-adaptin-binding protein p34	Homo sapiens (Human)			cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829
GN018505	GN018505.1	Q5F416	43.7	213	429	283	1.52e-41	151	TIPIN_CHICK	TIMELESS-interacting protein	Gallus gallus (Chicken)	cell cycle phase transition [GO:0044770]; DNA replication checkpoint signaling [GO:0000076]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; positive regulation of cell population proliferation [GO:0008284]; replication fork arrest [GO:0043111]; replication fork processing [GO:0031297]	DNA binding [GO:0003677]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; replication fork protection complex [GO:0031298]	GO:0000076; GO:0000785; GO:0003677; GO:0005634; GO:0005737; GO:0008284; GO:0031297; GO:0031298; GO:0031573; GO:0043111; GO:0044770
GN018506	GN018506.1	A0JM64	38.6	536	980	612	6.23e-75	261	KHDC4_XENTR	KH homology domain-containing protein 4 (Brings lots of money 7) (Pre-mRNA splicing factor protein khdc4)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	mRNA splice site recognition [GO:0006376]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0005737; GO:0006376
GN018507	GN018507.1	Q6NZ07	53.5	490	482	572	1.45e-173	503	NCLN_DANRE	BOS complex subunit ncln (Nicalin-1) (Nicastrin-like protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	determination of left/right asymmetry in lateral mesoderm [GO:0003140]; enteric nervous system development [GO:0048484]; multi-pass transmembrane protein insertion into ER membrane [GO:0160063]; negative regulation of nodal signaling pathway [GO:1900108]; regulation of signal transduction [GO:0009966]	ribosome binding [GO:0043022]	endoplasmic reticulum membrane [GO:0005789]; multi-pass translocon complex [GO:0160064]	GO:0003140; GO:0005789; GO:0009966; GO:0043022; GO:0048484; GO:0160063; GO:0160064; GO:1900108
GN018510	GN018510.1	A6NNX1	58.3	72	112	92	2.43e-21	84.0	RIAD1_HUMAN	RIIa domain-containing protein 1	Homo sapiens (Human)				
GN018512	GN018512.1	Q21565	46.2	390	464	687	4.78e-104	327	AMT3_CAEEL	Putative ammonium transporter 3	Caenorhabditis elegans	ammonium homeostasis [GO:0097272]	ammonium channel activity [GO:0008519]	membrane [GO:0016020]	GO:0008519; GO:0016020; GO:0097272
GN018513	GN018513.1	Q9VCA2	33.8	517	514	548	1.71e-80	264	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN018514	GN018514.1	Q5U2U0	44.2	527	573	633	2.15e-116	362	CLPX_RAT	ATP-dependent clpX-like chaperone, mitochondrial (EC 3.6.4.10) (ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial) (Caseinolytic mitochondrial matrix peptidase chaperone subunit X)	Rattus norvegicus (Rat)	ATP metabolic process [GO:0046034]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]; peptidase activator activity [GO:0016504]	endopeptidase Clp complex [GO:0009368]; mitochondrial endopeptidase Clp complex [GO:0009841]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	GO:0005524; GO:0005739; GO:0005759; GO:0006508; GO:0009368; GO:0009841; GO:0016504; GO:0016887; GO:0030163; GO:0042645; GO:0046034; GO:0140662
GN018515	GN018515.1	Q1RMR0	56.4	218	220	218	2.13e-37	132	RPC7L_BOVIN	DNA-directed RNA polymerase III subunit RPC7-like (RNA polymerase III subunit C7-like) (DNA-directed RNA polymerase III subunit G-like)	Bos taurus (Bovine)	transcription by RNA polymerase III [GO:0006383]		nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]	GO:0005634; GO:0005666; GO:0006383
GN018516	GN018516.1	Q2KIS3	47.3	112	117	380	5.27e-13	67.0	UBL7_BOVIN	Ubiquitin-like protein 7	Bos taurus (Bovine)	ubiquitin-dependent protein catabolic process [GO:0006511]			GO:0006511
GN018517	GN018517.1	Q05973	45.1	1772	2000	1522	0.0	1309	SCN1_HETBL	Sodium channel protein 1 brain (Sodium channel protein I brain)	Heterololigo bleekeri (Spear squid) (Loligo bleekeri)	membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]	voltage-gated sodium channel activity [GO:0005248]	voltage-gated sodium channel complex [GO:0001518]	GO:0001518; GO:0005248; GO:0019228; GO:0086010
GN018518	GN018518.1	Q9Z223	60.6	142	145	189	1.27e-59	185	MOC2B_MOUSE	Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B)	Mus musculus (Mouse)	Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor biosynthetic process [GO:0032324]	identical protein binding [GO:0042802]; molybdopterin synthase activity [GO:0030366]	cytosol [GO:0005829]; molybdopterin synthase complex [GO:1990140]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005829; GO:0006777; GO:0016607; GO:0030366; GO:0032324; GO:0042802; GO:1990140
GN018519	GN018519.1	Q2TBL4	29.3	509	348	533	4.41e-58	199	RPC3_BOVIN	DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C)	Bos taurus (Bovine)	positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; termination of RNA polymerase III transcription [GO:0006386]; transcription initiation at RNA polymerase III promoter [GO:0006384]	single-stranded DNA binding [GO:0003697]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]	GO:0003697; GO:0005634; GO:0005654; GO:0005666; GO:0006384; GO:0006386; GO:0032728; GO:0045089
GN018528	GN018528.1	Q8NFF2	47.9	480	723	622	7.77e-128	396	NCKX4_HUMAN	Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4)	Homo sapiens (Human)	amelogenesis [GO:0097186]; calcium ion export across plasma membrane [GO:1990034]; calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to high light intensity [GO:0071486]; cone photoresponse recovery [GO:0036368]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; drinking behavior [GO:0042756]; enamel mineralization [GO:0070166]; intracellular calcium ion homeostasis [GO:0006874]; membrane repolarization [GO:0086009]; negative regulation of calcium-mediated signaling [GO:0050849]; olfactory nerve maturation [GO:0021630]; phototransduction [GO:0007602]; potassium ion transmembrane transport [GO:0071805]; regulation of eating behavior [GO:1903998]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to high light intensity [GO:0009644]; response to melanocyte-stimulating hormone [GO:1990680]; response to odorant [GO:1990834]; sensory perception of smell [GO:0007608]; sodium ion transmembrane transport [GO:0035725]	calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]	apical plasma membrane [GO:0016324]; cone photoreceptor outer segment [GO:0120199]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GO:0005262; GO:0005516; GO:0005737; GO:0005886; GO:0006874; GO:0007602; GO:0007608; GO:0008273; GO:0008277; GO:0009644; GO:0016020; GO:0016324; GO:0021630; GO:0031982; GO:0035725; GO:0036368; GO:0042756; GO:0048306; GO:0050849; GO:0050911; GO:0055074; GO:0070166; GO:0070588; GO:0071486; GO:0071805; GO:0086009; GO:0097186; GO:0098703; GO:0120199; GO:1903998; GO:1990034; GO:1990680; GO:1990834
GN018530	GN018530.1	Q5BL29	54.3	289	296	309	4.74e-87	265	S39A9_DANRE	Zinc transporter ZIP9 (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) (ZIP-9)	Danio rerio (Zebrafish) (Brachydanio rerio)	bicellular tight junction assembly [GO:0070830]; egg activation [GO:0007343]; intracellular zinc ion homeostasis [GO:0006882]; regulation of cellular response to testosterone stimulus [GO:2000654]; regulation of vascular endothelial cell proliferation [GO:1905562]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	androgen binding [GO:0005497]; G protein-coupled receptor activity [GO:0004930]; zinc efflux transmembrane transporter activity [GO:0022883]; zinc ion transmembrane transporter activity [GO:0005385]	mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GO:0004930; GO:0005385; GO:0005497; GO:0005634; GO:0005739; GO:0005802; GO:0005886; GO:0006829; GO:0006882; GO:0007343; GO:0022883; GO:0031966; GO:0048471; GO:0070830; GO:0071577; GO:1905562; GO:2000654
GN018535	GN018535.1	Q0P4V4	35.3	590	972	785	2.05e-95	322	KTU_XENTR	Protein kintoun (Dynein assembly factor 2, axonemal)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285]		cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293]	GO:0005737; GO:0060285; GO:0070286; GO:0120293
GN018536	GN018536.1	Q17M80	65.3	101	121	521	6.75e-37	134	MMSA_AEDAE	Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (EC 1.2.1.27) (Malonate-semialdehyde dehydrogenase [acylating])	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	L-valine catabolic process [GO:0006574]; thymine catabolic process [GO:0006210]	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity [GO:0004491]	mitochondrion [GO:0005739]	GO:0004491; GO:0005739; GO:0006210; GO:0006574
GN018537	GN018537.1	Q7QC84	77.0	396	396	521	5.18e-222	620	MMSA_ANOGA	Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (EC 1.2.1.27) (Malonate-semialdehyde dehydrogenase [acylating])	Anopheles gambiae (African malaria mosquito)	L-valine catabolic process [GO:0006574]; thymine catabolic process [GO:0006210]	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity [GO:0004491]	mitochondrion [GO:0005739]	GO:0004491; GO:0005739; GO:0006210; GO:0006574
GN018539	GN018539.1	Q8IW19	40.6	96	582	511	1.00e-12	74.3	APLF_HUMAN	Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1)	Homo sapiens (Human)	DNA damage response [GO:0006974]; DNA repair [GO:0006281]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; embryo implantation [GO:0007566]; protein localization to chromatin [GO:0071168]; regulation of DNA repair [GO:0006282]; regulation of epithelial to mesenchymal transition [GO:0010717]; single strand break repair [GO:0000012]	3'-5' exonuclease activity [GO:0008408]; ADP-D-ribose modification-dependent protein binding [GO:0160002]; DNA endonuclease activity [GO:0004520]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; histone binding [GO:0042393]; histone chaperone activity [GO:0140713]; nucleotide binding [GO:0000166]; poly-ADP-D-ribose binding [GO:0072572]; protein folding chaperone [GO:0044183]	chromosome [GO:0005694]; cytosol [GO:0005829]; DNA ligase III-XRCC1 complex [GO:0070421]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; site of double-strand break [GO:0035861]	GO:0000012; GO:0000166; GO:0003906; GO:0004520; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0006281; GO:0006282; GO:0006302; GO:0006303; GO:0006974; GO:0007566; GO:0008408; GO:0010717; GO:0035861; GO:0042393; GO:0044183; GO:0070421; GO:0071168; GO:0072572; GO:0090734; GO:0140713; GO:0140861; GO:0160002
GN018540	GN018540.1	Q6P1K2	29.2	154	188	205	6.67e-16	75.5	PMF1_HUMAN	Polyamine-modulated factor 1 (PMF-1)	Homo sapiens (Human)	attachment of spindle microtubules to kinetochore [GO:0008608]; chromosome segregation [GO:0007059]; transcription by RNA polymerase II [GO:0006366]	leucine zipper domain binding [GO:0043522]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; kinetochore [GO:0000776]; MIS12/MIND type complex [GO:0000444]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; outer kinetochore [GO:0000940]; spindle pole [GO:0000922]; transcription regulator complex [GO:0005667]	GO:0000444; GO:0000776; GO:0000922; GO:0000940; GO:0003713; GO:0005634; GO:0005654; GO:0005667; GO:0005829; GO:0006366; GO:0007059; GO:0008608; GO:0043522
GN018541	GN018541.1	P04758	28.8	340	419	505	6.75e-37	144	ACHB_BOVIN	Acetylcholine receptor subunit beta	Bos taurus (Bovine)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic cation transport [GO:0006812]; monoatomic ion transmembrane transport [GO:0034220]; muscle cell development [GO:0055001]; muscle contraction [GO:0006936]; nervous system process [GO:0050877]; neuromuscular synaptic transmission [GO:0007274]; postsynaptic membrane organization [GO:0001941]; signal transduction [GO:0007165]; skeletal muscle contraction [GO:0003009]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; channel activity [GO:0015267]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0001941; GO:0003009; GO:0005886; GO:0005892; GO:0006812; GO:0006816; GO:0006936; GO:0007165; GO:0007271; GO:0007274; GO:0015267; GO:0015464; GO:0022848; GO:0034220; GO:0035095; GO:0043005; GO:0045202; GO:0045211; GO:0050877; GO:0051899; GO:0055001; GO:0095500
GN018542	GN018542.1	Q5IS76	27.6	301	372	494	1.38e-30	125	ACHA6_PANTR	Neuronal acetylcholine receptor subunit alpha-6	Pan troglodytes (Chimpanzee)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0014059; GO:0015464; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0060084; GO:0095500; GO:0097060; GO:0098691; GO:0099171
GN018543	GN018543.1	P04755	27.9	337	421	521	3.08e-36	142	ACH3_DROME	Acetylcholine receptor subunit beta-like 1 (Nicotinic acetylcholine receptor beta 1)	Drosophila melanogaster (Fruit fly)	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211
GN018548	GN018548.1	O62675	42.9	119	2016	630	1.51e-15	86.3	IL16_MACMU	Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]	Macaca mulatta (Rhesus macaque)	cytokine-mediated signaling pathway [GO:0019221]; induction of positive chemotaxis [GO:0050930]; positive regulation of inflammatory response [GO:0050729]	CD4 receptor binding [GO:0042609]; cytokine activity [GO:0005125]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0005125; GO:0005576; GO:0005634; GO:0005737; GO:0019221; GO:0042609; GO:0050729; GO:0050930
GN018549	GN018549.1	Q96L92	59.6	426	448	541	6.40e-181	519	SNX27_HUMAN	Sorting nexin-27	Homo sapiens (Human)	endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; establishment of natural killer cell polarity [GO:0001770]; intracellular protein transport [GO:0006886]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; regulation of synapse maturation [GO:0090128]; signal transduction [GO:0007165]	phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3-phosphate binding [GO:0032266]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; immunological synapse [GO:0001772]; postsynaptic early endosome [GO:0098842]; postsynaptic recycling endosome [GO:0098837]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0001770; GO:0001772; GO:0005768; GO:0005769; GO:0005829; GO:0006886; GO:0007165; GO:0008333; GO:0016197; GO:0031901; GO:0032266; GO:0032456; GO:0035091; GO:0090128; GO:0098685; GO:0098837; GO:0098842; GO:0098978; GO:0099072
GN018552	GN018552.1	Q7ZYC4	55.5	643	719	739	7.49e-250	712	ACBG2_XENLA	Long-chain-fatty-acid--CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 2) (Arachidonate--CoA ligase ACSBG2) (EC 6.2.1.15)	Xenopus laevis (African clawed frog)		arachidonate-CoA ligase activity [GO:0047676]; long-chain fatty acid-CoA ligase activity [GO:0004467]; very long-chain fatty acid-CoA ligase activity [GO:0031957]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	GO:0004467; GO:0005783; GO:0016020; GO:0031957; GO:0047676
GN018553	GN018553.1	Q9Y5K8	75.1	229	233	247	6.07e-113	326	VATD_HUMAN	V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D)	Homo sapiens (Human)	cellular response to amino acid stimulus [GO:0071230]; cilium assembly [GO:0060271]; endosomal lumen acidification [GO:0048388]; Golgi lumen acidification [GO:0061795]; intracellular pH reduction [GO:0051452]; lysosomal lumen acidification [GO:0007042]; positive regulation of TORC1 signaling [GO:1904263]; protein localization to cilium [GO:0061512]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; synaptic vesicle lumen acidification [GO:0097401]; vacuolar acidification [GO:0007035]	proton-transporting ATPase activity, rotational mechanism [GO:0046961]	centrosome [GO:0005813]; cilium [GO:0005929]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of synaptic vesicle membrane [GO:0098850]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosomal proton-transporting V-type ATPase complex [GO:0046611]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; specific granule membrane [GO:0035579]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]	GO:0000139; GO:0000221; GO:0005765; GO:0005813; GO:0005829; GO:0005886; GO:0005929; GO:0007035; GO:0007042; GO:0010008; GO:0016020; GO:0016241; GO:0030665; GO:0033176; GO:0035579; GO:0046611; GO:0046961; GO:0048388; GO:0051452; GO:0060271; GO:0061512; GO:0061795; GO:0070062; GO:0071230; GO:0097401; GO:0098850; GO:1902600; GO:1904263
GN018558	GN018558.1	P05419	72.9	59	74	131	2.01e-22	86.3	CALN_CHICK	Neo-calmodulin (NeoCaM)	Gallus gallus (Chicken)	calcineurin-mediated signaling [GO:0097720]; detection of calcium ion [GO:0005513]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	calcium ion binding [GO:0005509]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; myelin sheath [GO:0043209]; nucleus [GO:0005634]	GO:0005509; GO:0005513; GO:0005634; GO:0005737; GO:0005813; GO:0010880; GO:0043209; GO:0097720
GN018573	GN018573.1	Q5F3X0	44.1	356	363	378	5.66e-99	301	LCLT1_CHICK	Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (EC 2.3.1.51) (Acyl-CoA:lysocardiolipin acyltransferase 1)	Gallus gallus (Chicken)	CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidylinositol acyl-chain remodeling [GO:0036149]	1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0003841; GO:0005783; GO:0005789; GO:0016024; GO:0036149
GN018574	GN018574.1	Q08CA1	48.8	166	171	343	6.18e-44	151	GDPP1_DANRE	GDP-D-glucose phosphorylase 1 (EC 2.7.7.78)	Danio rerio (Zebrafish) (Brachydanio rerio)	glucose metabolic process [GO:0006006]	GDP-D-glucose phosphorylase activity [GO:0080048]	cytoplasm [GO:0005737]	GO:0005737; GO:0006006; GO:0080048
GN018575	GN018575.1	B6NXD5	46.3	309	305	383	6.28e-97	293	BABA2_BRAFL	BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein)	Branchiostoma floridae (Florida lancelet) (Amphioxus)	double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212]	polyubiquitin modification-dependent protein binding [GO:0031593]	BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0006302; GO:0007095; GO:0010212; GO:0031593; GO:0045739; GO:0070531; GO:0070552
GN018577	GN018577.1	Q60969	57.1	191	218	223	6.10e-70	216	STYX_MOUSE	Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase Styx) (Phosphoserine/threonine/tyrosine interaction protein)	Mus musculus (Mouse)	negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process [GO:0062026]; regulation of ERK1 and ERK2 cascade [GO:0070372]; spermatogenesis [GO:0007283]	F-box domain binding [GO:1990444]; pseudophosphatase activity [GO:0001691]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001691; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007283; GO:0062026; GO:0070372; GO:1990444
GN018578	GN018578.1	P91809	94.1	152	251	265	8.21e-96	284	TBP_STRPU	TATA-box-binding protein (TATA sequence-binding protein) (TBP) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)	Strongylocentrotus purpuratus (Purple sea urchin)	DNA-templated transcription initiation [GO:0006352]	DNA binding [GO:0003677]; RNA polymerase II general transcription initiation factor activity [GO:0016251]	nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0006352; GO:0016251
GN018579	GN018579.1	D3YXG0	40.4	255	705	5634	2.36e-51	197	HMCN1_MOUSE	Hemicentin-1 (Fibulin-6) (FIBL-6)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]; response to bacterium [GO:0009617]	calcium ion binding [GO:0005509]; cell adhesion mediator activity [GO:0098631]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; muscle tendon junction [GO:0005927]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005509; GO:0005576; GO:0005604; GO:0005737; GO:0005886; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0009617; GO:0030036; GO:0030054; GO:0031012; GO:0032154; GO:0070161; GO:0071711; GO:0098631; GO:0140144
GN018581	GN018581.1	Q86UA1	51.4	572	700	669	4.52e-183	539	PRP39_HUMAN	Pre-mRNA-processing factor 39 (PRP39 homolog)	Homo sapiens (Human)	mRNA 5'-splice site recognition [GO:0000395]		commitment complex [GO:0000243]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]	GO:0000243; GO:0000395; GO:0005685; GO:0071004
GN018582	GN018582.1	Q5I0I4	35.3	156	295	254	1.58e-21	94.4	DMAC2_RAT	Distal membrane-arm assembly complex protein 2 (ATP synthase subunit s-like protein)	Rattus norvegicus (Rat)	mitochondrial respiratory chain complex I assembly [GO:0032981]		mitochondrion [GO:0005739]	GO:0005739; GO:0032981
GN018583	GN018583.1	Q13395	29.7	1361	1518	1621	6.70e-182	589	TARB1_HUMAN	tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1 (EC 2.1.1.34) (TAR RNA-binding protein 1) (TAR RNA-binding protein of 185 kDa) (TRP-185)	Homo sapiens (Human)	regulation of transcription by RNA polymerase II [GO:0006357]; tRNA methylation [GO:0030488]	RNA binding [GO:0003723]; tRNA (guanine(18)-2'-O-ribose)-methyltransferase activity [GO:0141100]; tRNA (guanine) methyltransferase activity [GO:0016423]	nucleus [GO:0005634]	GO:0003723; GO:0005634; GO:0006357; GO:0016423; GO:0030488; GO:0141100
GN018585	GN018585.1	Q9UQ84	45.9	122	488	846	1.83e-22	104	EXO1_HUMAN	Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI)	Homo sapiens (Human)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand resection involved in replication fork processing [GO:0110025]; mismatch repair [GO:0006298]; t-circle formation [GO:0090656]	5'-3' DNA exonuclease activity [GO:0035312]; 5'-3' exonuclease activity [GO:0008409]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; double-stranded DNA 5'-3' DNA exonuclease activity [GO:0051908]; exonuclease activity [GO:0004527]; flap endonuclease activity [GO:0048256]; metal ion binding [GO:0046872]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]	nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003677; GO:0003682; GO:0004523; GO:0004527; GO:0005634; GO:0005654; GO:0006281; GO:0006298; GO:0006310; GO:0008409; GO:0016604; GO:0035312; GO:0045145; GO:0046872; GO:0048256; GO:0051908; GO:0090656; GO:0110025
GN018586	GN018586.1	Q803U7	63.8	188	192	806	6.82e-78	251	EXO1_DANRE	Exonuclease 1 (EC 3.1.-.-) (Exonuclease I)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA recombination [GO:0006310]; mismatch repair [GO:0006298]	5'-3' DNA exonuclease activity [GO:0035312]; DNA binding [GO:0003677]; flap endonuclease activity [GO:0048256]; metal ion binding [GO:0046872]; single-stranded DNA 5'-3' DNA exonuclease activity [GO:0045145]	nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0006298; GO:0006310; GO:0035312; GO:0045145; GO:0046872; GO:0048256
GN018588	GN018588.1	B1H285	29.0	621	646	575	1.65e-72	247	KBTB8_RAT	Kelch repeat and BTB domain-containing protein 8	Rattus norvegicus (Rat)	neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; spindle [GO:0005819]	GO:0005737; GO:0005794; GO:0005819; GO:0006513; GO:0014029; GO:0014032; GO:0031463; GO:0043161; GO:1990756
GN018589	GN018589.1	Q9NY33	58.5	414	411	737	5.85e-155	458	DPP3_HUMAN	Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B)	Homo sapiens (Human)	proteolysis [GO:0006508]	dipeptidyl-peptidase activity [GO:0008239]; metalloexopeptidase activity [GO:0008235]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0005737; GO:0005829; GO:0006508; GO:0008235; GO:0008239; GO:0008270; GO:0070062
GN018590	GN018590.1	A7RZW4	63.0	135	139	729	3.97e-48	167	DPP3_NEMVE	Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III)	Nematostella vectensis (Starlet sea anemone)	proteolysis [GO:0006508]	dipeptidyl-peptidase activity [GO:0008239]; metalloexopeptidase activity [GO:0008235]	cytoplasm [GO:0005737]	GO:0005737; GO:0006508; GO:0008235; GO:0008239
GN018591	GN018591.1	Q8BMQ3	42.1	508	1015	1127	5.79e-88	309	BNC2_MOUSE	Zinc finger protein basonuclin-2	Mus musculus (Mouse)	endochondral bone growth [GO:0003416]; mesenchyme development [GO:0060485]; regulation of DNA-templated transcription [GO:0006355]; roof of mouth development [GO:0060021]; tongue development [GO:0043586]	DNA binding [GO:0003677]; rDNA binding [GO:0000182]	chromatin [GO:0000785]; fibrillar center [GO:0001650]; nuclear body [GO:0016604]; nucleus [GO:0005634]	GO:0000182; GO:0000785; GO:0001650; GO:0003416; GO:0003677; GO:0005634; GO:0006355; GO:0016604; GO:0043586; GO:0060021; GO:0060485
GN018594	GN018594.1	Q0IIF9	41.5	207	223	543	1.52e-48	169	CP2U1_BOVIN	Cytochrome P450 2U1 (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)	Bos taurus (Bovine)	steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805]	arachidonate omega-hydroxylase activity [GO:0052869]; fatty acid omega-1 hydroxylase activity [GO:0120502]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; long-chain fatty acid omega-hydroxylase activity [GO:0102033]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; steroid hydroxylase activity [GO:0008395]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial inner membrane [GO:0005743]	GO:0005506; GO:0005737; GO:0005743; GO:0005789; GO:0006805; GO:0008202; GO:0008395; GO:0016712; GO:0020037; GO:0052869; GO:0102033; GO:0120502
GN018597	GN018597.1	Q3ZBD2	56.6	106	122	417	1.36e-36	131	ARP10_BOVIN	Actin-related protein 10	Bos taurus (Bovine)	retrograde axonal transport of mitochondrion [GO:0098958]	structural constituent of cytoskeleton [GO:0005200]	axon cytoplasm [GO:1904115]; dynactin complex [GO:0005869]; nucleus [GO:0005634]	GO:0005200; GO:0005634; GO:0005869; GO:0098958; GO:1904115
GN018600	GN018600.1	Q5E9H5	64.3	417	420	419	7.65e-201	563	BCS1_BOVIN	Mitochondrial chaperone BCS1 (EC 3.6.1.-) (BCS1-like protein)	Bos taurus (Bovine)	mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrial respiratory chain complex III assembly [GO:0034551]; mitochondrial respiratory chain complex IV assembly [GO:0033617]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	mitochondrial inner membrane [GO:0005743]	GO:0005524; GO:0005743; GO:0016887; GO:0032979; GO:0032981; GO:0033617; GO:0034551
GN018603	GN018603.1	O08564	36.1	216	302	282	6.55e-39	141	PLPP1_RAT	Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a)	Rattus norvegicus (Rat)	ceramide metabolic process [GO:0006672]; phospholipid catabolic process [GO:0009395]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165]; sphingosine metabolic process [GO:0006670]	ceramide-1-phosphate phosphatase activity [GO:0106235]; diacylglycerol diphosphate phosphatase activity [GO:0000810]; lipid phosphatase activity [GO:0042577]; lysophosphatidic acid phosphatase activity [GO:0052642]; phosphatidate phosphatase activity [GO:0008195]; sphingosine-1-phosphate phosphatase activity [GO:0042392]	apical plasma membrane [GO:0016324]; caveola [GO:0005901]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0000810; GO:0005886; GO:0005901; GO:0006644; GO:0006670; GO:0006672; GO:0007165; GO:0008195; GO:0009395; GO:0016020; GO:0016324; GO:0042392; GO:0042577; GO:0045121; GO:0046839; GO:0052642; GO:0106235
GN018605	GN018605.1	Q5VWW1	35.2	108	355	255	9.59e-10	62.0	C1QL3_HUMAN	Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0097107; GO:0098686; GO:0098978; GO:0099550; GO:0099558; GO:0099645
GN018607	GN018607.1	Q5VWW1	35.2	108	588	255	3.93e-09	61.2	C1QL3_HUMAN	Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0097107; GO:0098686; GO:0098978; GO:0099550; GO:0099558; GO:0099645
GN018611	GN018611.1	P05419	57.3	110	114	131	3.21e-37	125	CALN_CHICK	Neo-calmodulin (NeoCaM)	Gallus gallus (Chicken)	calcineurin-mediated signaling [GO:0097720]; detection of calcium ion [GO:0005513]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]	calcium ion binding [GO:0005509]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; myelin sheath [GO:0043209]; nucleus [GO:0005634]	GO:0005509; GO:0005513; GO:0005634; GO:0005737; GO:0005813; GO:0010880; GO:0043209; GO:0097720
GN018612	GN018612.1	A5PJS2	50.2	227	386	257	1.17e-73	233	S5A1_BOVIN	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.22) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1)	Bos taurus (Bovine)	androgen biosynthetic process [GO:0006702]; male gonad development [GO:0008584]	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity [GO:0047751]; 3-oxo-5-alpha-steroid 4-dehydrogenase activity [GO:0003865]	endoplasmic reticulum membrane [GO:0005789]; neuronal cell body [GO:0043025]	GO:0003865; GO:0005789; GO:0006702; GO:0008584; GO:0043025; GO:0047751
GN018613	GN018613.1	P0DMQ5	81.0	42	107	153	2.74e-14	67.4	INAM2_HUMAN	Putative transmembrane protein INAFM2 (InaF-motif-containing protein 2) (Osteogenesis up-regulated transcript 1)	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN018617	GN018617.1	P22122	33.5	182	225	192	6.84e-22	92.0	RHO_DIPOM	Ras-like GTP-binding protein O-RHO (EC 3.6.5.2)	Diplobatis ommata (Ocellated electric ray) (Discopyge ommata)	small GTPase-mediated signal transduction [GO:0007264]	G protein activity [GO:0003925]; GTP binding [GO:0005525]	plasma membrane [GO:0005886]	GO:0003925; GO:0005525; GO:0005886; GO:0007264
GN018620	GN018620.1	P0CT33	34.0	94	138	1887	1.18e-09	58.5	TLH1_SCHPO	ATP-dependent DNA helicase tlh1 (EC 5.6.2.4) (DNA 3'-5' helicase tlh1) (Sub-telomeric helicase RecQ homolog 1) (Telomere-linked helicase 1)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	telomere maintenance via recombination [GO:0000722]	3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; chromosome, telomeric repeat region [GO:0140445]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000722; GO:0003676; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0008270; GO:0016887; GO:0043138; GO:0140445
GN018626	GN018626.1	Q9VR91	41.6	89	270	4912	2.15e-09	61.6	HERC2_DROME	Probable E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)	Drosophila melanogaster (Fruit fly)	protein ubiquitination [GO:0016567]; regulation of signal transduction [GO:0009966]	metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004842; GO:0005634; GO:0005737; GO:0005814; GO:0009966; GO:0016567; GO:0046872; GO:0061630
GN018629	GN018629.1	Q3U3Q1	37.1	377	315	472	7.02e-66	217	ULK3_MOUSE	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3)	Mus musculus (Mouse)	autophagosome assembly [GO:0000045]; fibroblast activation [GO:0072537]; mitophagy [GO:0000423]; negative regulation of smoothened signaling pathway [GO:0045879]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of smoothened signaling pathway [GO:0045880]; protein autophosphorylation [GO:0046777]; regulation of autophagy [GO:0010506]; response to starvation [GO:0042594]; reticulophagy [GO:0061709]; smoothened signaling pathway [GO:0007224]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]	GO:0000045; GO:0000407; GO:0000423; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0007224; GO:0010506; GO:0034045; GO:0034727; GO:0042594; GO:0045879; GO:0045880; GO:0046777; GO:0061709; GO:0072537; GO:0106310
GN018630	GN018630.1	A6QQM4	56.4	376	673	454	4.87e-131	397	ZN474_BOVIN	Zinc finger protein 474	Bos taurus (Bovine)				
GN018631	GN018631.1	P86964	36.8	125	338	157	1.92e-20	89.7	KCP3_PINMA	BPTI/Kunitz domain-containing protein 3 (Nacre serine protease inhibitor 2) (NSPI2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]	GO:0004867; GO:0005576
GN018632	GN018632.1	P86964	37.8	119	275	157	2.64e-19	85.5	KCP3_PINMA	BPTI/Kunitz domain-containing protein 3 (Nacre serine protease inhibitor 2) (NSPI2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]	GO:0004867; GO:0005576
GN018633	GN018633.1	P86964	35.3	119	520	157	2.64e-14	73.9	KCP3_PINMA	BPTI/Kunitz domain-containing protein 3 (Nacre serine protease inhibitor 2) (NSPI2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]	GO:0004867; GO:0005576
GN018634	GN018634.1	P86964	35.3	119	643	157	3.41e-14	73.9	KCP3_PINMA	BPTI/Kunitz domain-containing protein 3 (Nacre serine protease inhibitor 2) (NSPI2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]	GO:0004867; GO:0005576
GN018635	GN018635.1	Q9DE25	52.6	116	273	476	2.24e-32	127	FXC1A_DANRE	Forkhead box C1-A	Danio rerio (Zebrafish) (Brachydanio rerio)	adrenal gland development [GO:0030325]; anatomical structure morphogenesis [GO:0009653]; blood vessel development [GO:0001568]; camera-type eye development [GO:0043010]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cerebellum vasculature development [GO:0061300]; closure of optic fissure [GO:0061386]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; heart development [GO:0007507]; motor neuron axon guidance [GO:0008045]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; neural crest cell migration [GO:0001755]; pectoral fin development [GO:0033339]; podocyte cell fate commitment [GO:0072149]; podocyte development [GO:0072015]; pronephric glomerulus development [GO:0039021]; regulation of bone mineralization [GO:0030500]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; regulation of Notch signaling pathway [GO:0008593]; regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vascular permeability [GO:0043114]; somitogenesis [GO:0001756]; vascular associated smooth muscle cell differentiation [GO:0035886]; vasculature development [GO:0001944]	chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001568; GO:0001755; GO:0001756; GO:0001944; GO:0003682; GO:0005634; GO:0006357; GO:0007368; GO:0007507; GO:0008045; GO:0008593; GO:0009653; GO:0030154; GO:0030325; GO:0030500; GO:0033339; GO:0035469; GO:0035886; GO:0039021; GO:0040036; GO:0043010; GO:0043114; GO:0048387; GO:0051216; GO:0060059; GO:0061300; GO:0061371; GO:0061386; GO:0071910; GO:0072015; GO:0072149; GO:2000583
GN018637	GN018637.1	Q5ZJQ3	75.0	104	112	112	6.44e-49	154	LIN52_CHICK	Protein lin-52 homolog	Gallus gallus (Chicken)	regulation of DNA-templated transcription [GO:0006355]		DRM complex [GO:0070176]	GO:0006355; GO:0070176
GN018638	GN018638.1	O15182	84.4	160	185	167	5.45e-90	263	CETN3_HUMAN	Centrin-3	Homo sapiens (Human)	centrosome cycle [GO:0007098]; microtubule cytoskeleton organization [GO:0000226]; mRNA export from nucleus [GO:0006406]; positive regulation of transcription by RNA polymerase II [GO:0045944]	calcium ion binding [GO:0005509]; G-protein beta/gamma-subunit complex binding [GO:0031683]; microtubule binding [GO:0008017]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; microtubule organizing center [GO:0005815]; nuclear envelope [GO:0005635]; nuclear pore nuclear basket [GO:0044615]; nucleolus [GO:0005730]; photoreceptor connecting cilium [GO:0032391]; transcription export complex 2 [GO:0070390]	GO:0000226; GO:0005509; GO:0005635; GO:0005730; GO:0005813; GO:0005814; GO:0005815; GO:0006406; GO:0007098; GO:0008017; GO:0031683; GO:0032391; GO:0036064; GO:0044615; GO:0045944; GO:0070390
GN018640	GN018640.1	Q8WNV7	53.5	269	278	279	2.04e-94	282	DHRS4_PIG	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (EC 1.1.1.300) (NADPH-dependent carbonyl reductase) (CR) (PHCR) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (Peroxisomal carbonyl reductase) (PerCR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (Short chain dehydrogenase/reductase family 25C member 2) (Protein SDR25C2)	Sus scrofa (Pig)	ketone metabolic process [GO:0042180]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202]	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity [GO:0000253]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; carbonyl reductase (NADPH) activity [GO:0004090]; identical protein binding [GO:0042802]	mitochondrion [GO:0005739]; peroxisome [GO:0005777]	GO:0000253; GO:0001523; GO:0004090; GO:0005739; GO:0005777; GO:0008202; GO:0042180; GO:0042574; GO:0042802; GO:0052650
GN018644	GN018644.1	Q21279	41.3	470	553	513	6.19e-122	371	TTL15_CAEEL	Probable tubulin polyglutamylase ttll-15 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 15)	Caenorhabditis elegans	egg-laying behavior [GO:0018991]			GO:0018991
GN018645	GN018645.1	Q9D0T2	37.5	299	318	339	8.93e-61	200	DUS12_MOUSE	Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase T-DSP4) (Dual specificity phosphatase VH1)	Mus musculus (Mouse)	dephosphorylation [GO:0016311]; positive regulation of hexokinase activity [GO:1903301]; protein dephosphorylation [GO:0006470]	kinase binding [GO:0019900]; phosphatase activity [GO:0016791]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004721; GO:0004722; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006470; GO:0008138; GO:0008270; GO:0016311; GO:0016791; GO:0019900; GO:1903301
GN018646	GN018646.1	P49109	48.0	502	530	533	5.83e-171	496	FMO5_CAVPO	Flavin-containing monooxygenase 5 (FMO 5) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (NADPH oxidase) (EC 1.6.3.1)	Cavia porcellus (Guinea pig)	regulation of cholesterol metabolic process [GO:0090181]; xenobiotic metabolic process [GO:0006805]	flavin adenine dinucleotide binding [GO:0050660]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADP binding [GO:0050661]	endoplasmic reticulum membrane [GO:0005789]	GO:0004497; GO:0004499; GO:0005789; GO:0006805; GO:0016174; GO:0050660; GO:0050661; GO:0090181
GN018653	GN018653.1	A0ZT93	28.6	126	152	168	4.49e-11	60.8	ISP2_BRASG	Type-2 ice-structuring protein (Type II antifreeze protein) (lpAFP)	Brachyopsis segaliensis (Sea poacher) (Brachyopsis rostratus)			extracellular region [GO:0005576]	GO:0005576
GN018663	GN018663.1	O50655	23.8	315	339	341	4.36e-12	69.7	XERD_SELRU	Integrase/recombinase xerD homolog	Selenomonas ruminantium	DNA integration [GO:0015074]; DNA recombination [GO:0006310]	DNA binding [GO:0003677]		GO:0003677; GO:0006310; GO:0015074
GN018667	GN018667.1	Q865K9	37.0	327	324	354	2.52e-59	197	MPRB_PIG	Membrane progestin receptor beta (mPR beta) (Progestin and adipoQ receptor family member VIII)	Sus scrofa (Pig)	response to steroid hormone [GO:0048545]	nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]	plasma membrane [GO:0005886]	GO:0003707; GO:0005496; GO:0005886; GO:0048545
GN018668	GN018668.1	Q96M34	52.5	40	126	536	4.70e-09	56.2	TEX55_HUMAN	Testis-specific expressed protein 55 (Testis-specific conserved, cAMP-dependent type II PK-anchoring protein)	Homo sapiens (Human)			nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005634; GO:0036126
GN018669	GN018669.1	Q9DBT3	37.3	276	309	340	1.41e-31	123	CCD97_MOUSE	Coiled-coil domain-containing protein 97	Mus musculus (Mouse)			nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654
GN018676	GN018676.1	Q8NA03	31.5	337	732	581	6.57e-19	94.7	FSIP1_HUMAN	Fibrous sheath-interacting protein 1	Homo sapiens (Human)				
GN018679	GN018679.1	Q6GM78	47.9	317	327	309	1.53e-88	270	ASGL1_XENLA	Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain]	Xenopus laevis (African clawed frog)	L-asparagine catabolic process [GO:0006530]	asparaginase activity [GO:0004067]; beta-aspartyl-peptidase activity [GO:0008798]	cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917]	GO:0001917; GO:0004067; GO:0005737; GO:0006530; GO:0008798
GN018701	GN018701.1	Q99758	38.5	577	560	1704	1.16e-102	343	ABCA3_HUMAN	Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ABC-C transporter) (ATP-binding cassette sub-family A member 3) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form]	Homo sapiens (Human)	lipid transport [GO:0006869]; lung development [GO:0030324]; organelle assembly [GO:0070925]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid homeostasis [GO:0055091]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of protein homooligomerization [GO:0032464]; positive regulation of vesicle fusion [GO:0031340]; regulation of lipid biosynthetic process [GO:0046890]; regulation of phosphatidylcholine metabolic process [GO:0150172]; response to glucocorticoid [GO:0051384]; response to xenobiotic stimulus [GO:0009410]; surfactant homeostasis [GO:0043129]; xenobiotic export from cell [GO:0046618]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid carrier activity [GO:0005319]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine transfer activity [GO:0120019]	alveolar lamellar body [GO:0097208]; alveolar lamellar body membrane [GO:0097233]; cytoplasmic vesicle membrane [GO:0030659]; extracellular region [GO:0005576]; lamellar body [GO:0042599]; lamellar body membrane [GO:0097232]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]	GO:0005319; GO:0005524; GO:0005576; GO:0005765; GO:0005770; GO:0005886; GO:0006855; GO:0006869; GO:0008559; GO:0009410; GO:0010875; GO:0015914; GO:0016887; GO:0030324; GO:0030659; GO:0031340; GO:0031902; GO:0032464; GO:0032585; GO:0042599; GO:0042626; GO:0042908; GO:0043129; GO:0046470; GO:0046471; GO:0046618; GO:0046890; GO:0051384; GO:0055091; GO:0070925; GO:0097208; GO:0097232; GO:0097233; GO:0120019; GO:0140326; GO:0140345; GO:0150172; GO:1902995; GO:2001140
GN018707	GN018707.1	Q55E58	24.1	444	868	3184	4.93e-17	90.5	PATS1_DICDI	Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1)	Dictyostelium discoideum (Social amoeba)	cheating during chimeric sorocarp development [GO:0099139]; mitotic cytokinesis [GO:0000281]; phosphatidylinositol dephosphorylation [GO:0046856]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actomyosin [GO:0042641]; cytosol [GO:0005829]; membrane [GO:0016020]	GO:0000281; GO:0004438; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0005829; GO:0016020; GO:0042641; GO:0046856; GO:0099139; GO:0106310
GN018708	GN018708.1	Q8K9J1	26.3	274	834	264	1.55e-13	75.1	Y343_BUCAP	Uncharacterized metal-dependent hydrolase BUsg_343 (EC 3.1.-.-)	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)		DNA nuclease activity [GO:0004536]; hydrolase activity, acting on ester bonds [GO:0016788]	cytosol [GO:0005829]	GO:0004536; GO:0005829; GO:0016788
GN018717	GN018717.1	Q17QH6	43.8	64	64	267	5.64e-11	58.5	COL11_BOVIN	Collectin-11 (Collectin kidney protein 1) (CL-K1)	Bos taurus (Bovine)	antimicrobial humoral response [GO:0019730]; complement activation, lectin pathway [GO:0001867]; developmental process [GO:0032502]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]	calcium ion binding [GO:0005509]; calcium-dependent carbohydrate binding [GO:0120153]; D-mannose binding [GO:0005537]; DNA binding [GO:0003677]; fucose binding [GO:0042806]; identical protein binding [GO:0042802]; oligosaccharide binding [GO:0070492]	extracellular region [GO:0005576]	GO:0001867; GO:0003677; GO:0005509; GO:0005537; GO:0005576; GO:0006508; GO:0019730; GO:0032502; GO:0042802; GO:0042806; GO:0070492; GO:0120153; GO:1903028
GN018719	GN018719.1	Q5FWU8	52.0	433	451	439	2.39e-159	460	ZMY10_XENLA	Zinc finger MYND domain-containing protein 10	Xenopus laevis (African clawed frog)	inner dynein arm assembly [GO:0036159]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; positive regulation of motile cilium assembly [GO:1905505]		apical plasma membrane [GO:0016324]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293]	GO:0005737; GO:0016324; GO:0034451; GO:0036158; GO:0036159; GO:0044458; GO:0120293; GO:1905505
GN018723	GN018723.1	Q86UP9	43.4	198	265	236	2.63e-55	181	LHPL3_HUMAN	LHFPL tetraspan subfamily member 3 protein (Lipoma HMGIC fusion partner-like 3 protein)	Homo sapiens (Human)	sensory perception of sound [GO:0007605]		plasma membrane [GO:0005886]	GO:0005886; GO:0007605
GN018724	GN018724.1	Q9WTS8	50.0	184	286	335	3.43e-49	169	FCN1_RAT	Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)	Rattus norvegicus (Rat)	cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of interleukin-8 production [GO:0032757]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; pattern recognition receptor activity [GO:0038187]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]	GO:0001867; GO:0002752; GO:0003823; GO:0005102; GO:0005576; GO:0005886; GO:0007186; GO:0009986; GO:0031012; GO:0032757; GO:0033691; GO:0038187; GO:0097367; GO:0106139
GN018727	GN018727.1	Q8R431	40.9	269	281	303	1.52e-66	212	MGLL_RAT	Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL)	Rattus norvegicus (Rat)	acylglycerol catabolic process [GO:0046464]; arachidonate metabolic process [GO:0019369]; long-term synaptic depression [GO:0060292]; monoacylglycerol catabolic process [GO:0052651]; positive regulation of vasoconstriction [GO:0045907]; regulation of axon extension [GO:0030516]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of inflammatory response [GO:0050727]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]; regulation of sensory perception of pain [GO:0051930]; regulation of signal transduction [GO:0009966]; response to ethanol [GO:0045471]; triglyceride catabolic process [GO:0019433]	hydrolase activity [GO:0016787]; monoacylglycerol lipase activity [GO:0047372]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; parallel fiber to Purkinje cell synapse [GO:0098688]; presynapse [GO:0098793]; synapse [GO:0045202]; varicosity [GO:0043196]	GO:0005811; GO:0005829; GO:0009966; GO:0016020; GO:0016787; GO:0019369; GO:0019433; GO:0030424; GO:0030516; GO:0042803; GO:0043196; GO:0045202; GO:0045471; GO:0045907; GO:0046464; GO:0047372; GO:0050727; GO:0051930; GO:0052651; GO:0060292; GO:0098688; GO:0098793; GO:0099178; GO:0150053; GO:2000124
GN018728	GN018728.1	Q9WYJ1	32.7	321	327	401	2.59e-43	156	TSAL_THEMA	L-threonine ammonia-lyase (EC 4.3.1.19) (L-serine ammonia-lyase) (EC 4.3.1.17) (Threonine dehydratase)	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	L-serine catabolic process [GO:0006565]; L-threonine catabolic process [GO:0006567]	L-serine ammonia-lyase activity [GO:0003941]; pyridoxal phosphate binding [GO:0030170]; threonine deaminase activity [GO:0004794]		GO:0003941; GO:0004794; GO:0006565; GO:0006567; GO:0030170
GN018731	GN018731.1	Q0P4F7	27.2	239	230	606	4.05e-14	74.3	ACSF2_DANRE	Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2)	Danio rerio (Zebrafish) (Brachydanio rerio)		medium-chain fatty acid-CoA ligase activity [GO:0031956]	mitochondrion [GO:0005739]	GO:0005739; GO:0031956
GN018734	GN018734.1	Q28DE6	69.2	107	692	782	1.48e-41	165	RSBNL_XENTR	Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			nucleus [GO:0005634]	GO:0005634
GN018738	GN018738.1	O14929	51.5	377	383	419	3.95e-125	370	HAT1_HUMAN	Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1) (Histone methacryltransferase HAT1) (EC 2.3.1.-)	Homo sapiens (Human)	chromosome organization [GO:0051276]; DNA replication-dependent chromatin assembly [GO:0006335]; internal protein amino acid acetylation [GO:0006475]; subtelomeric heterochromatin formation [GO:0031509]	histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; histone H4K12 acetyltransferase activity [GO:0043997]; histone methacryltransferase activity [GO:0140218]; protein-lysine-acetyltransferase activity [GO:0061733]	chromatin [GO:0000785]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; histone acetyltransferase complex [GO:0000123]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000123; GO:0000781; GO:0000785; GO:0004402; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0006335; GO:0006475; GO:0016363; GO:0031509; GO:0032991; GO:0042393; GO:0043997; GO:0051276; GO:0061733; GO:0140218
GN018742	GN018742.1	Q5RB35	60.5	727	725	735	0.0	896	MKLN1_PONAB	Muskelin	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	actin cytoskeleton organization [GO:0030036]; cell-matrix adhesion [GO:0007160]; neurotransmitter receptor transport postsynaptic membrane to endosome [GO:0098968]; regulation of cell shape [GO:0008360]; regulation of receptor internalization [GO:0002090]	protein homodimerization activity [GO:0042803]	cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GABA-ergic synapse [GO:0098982]; nucleoplasm [GO:0005654]; postsynapse [GO:0098794]; postsynaptic endosome membrane [GO:0098895]; postsynaptic specialization membrane of symmetric synapse [GO:0099164]; ruffle [GO:0001726]; synapse [GO:0045202]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0001726; GO:0002090; GO:0005654; GO:0005737; GO:0005829; GO:0005938; GO:0007160; GO:0008360; GO:0030036; GO:0042803; GO:0045202; GO:0098794; GO:0098895; GO:0098968; GO:0098982; GO:0099164
GN018745	GN018745.1	P18426	36.9	203	200	205	1.74e-33	121	SCR11_NOTSL	S-crystallin SL11 (Major lens polypeptide)	Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei)	glutathione metabolic process [GO:0006749]	glutathione transferase activity [GO:0004364]		GO:0004364; GO:0006749
GN018746	GN018746.1	P18426	40.0	95	103	205	3.69e-10	57.4	SCR11_NOTSL	S-crystallin SL11 (Major lens polypeptide)	Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei)	glutathione metabolic process [GO:0006749]	glutathione transferase activity [GO:0004364]		GO:0004364; GO:0006749
GN018747	GN018747.1	P46434	39.0	200	200	235	2.94e-32	119	GST1_ONCVO	Glutathione S-transferase 1 (EC 2.5.1.18)	Onchocerca volvulus	glutathione metabolic process [GO:0006749]	glutathione peroxidase activity [GO:0004602]; glutathione transferase activity [GO:0004364]		GO:0004364; GO:0004602; GO:0006749
GN018748	GN018748.1	Q04073	50.7	452	479	459	1.17e-119	361	P3A2_STRPU	DNA-binding protein P3A2	Strongylocentrotus purpuratus (Purple sea urchin)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357
GN018749	GN018749.1	P02553	90.1	162	167	161	1.25e-105	301	TBA_LYTPI	Tubulin alpha chain (EC 3.6.5.-)	Lytechinus pictus (Painted sea urchin)	microtubule-based process [GO:0007017]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]	microtubule [GO:0005874]	GO:0003924; GO:0005200; GO:0005525; GO:0005874; GO:0007017
GN018750	GN018750.1	P49116	53.1	497	709	596	5.18e-159	475	NR2C2_HUMAN	Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)	Homo sapiens (Human)	cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of embryonic development [GO:0040019]; positive regulation of JNK cascade [GO:0046330]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0004879; GO:0005634; GO:0005654; GO:0006355; GO:0007399; GO:0008270; GO:0030154; GO:0033209; GO:0040019; GO:0043123; GO:0043565; GO:0045944; GO:0046330; GO:1990837
GN018751	GN018751.1	Q07E01	28.4	846	824	1382	3.93e-75	270	MET_ORNAN	Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)	Ornithorhynchus anatinus (Duckbill platypus)	cell development [GO:0048468]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; liver development [GO:0001889]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; regulation of gene expression [GO:0010468]; semaphorin-plexin signaling pathway [GO:0071526]	ATP binding [GO:0005524]; hepatocyte growth factor receptor activity [GO:0005008]; semaphorin receptor activity [GO:0017154]	basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001889; GO:0005008; GO:0005524; GO:0005886; GO:0007169; GO:0009925; GO:0010468; GO:0017154; GO:0030182; GO:0031016; GO:0043235; GO:0048468; GO:0050918; GO:0071526; GO:2001028
GN018753	GN018753.1	P35465	51.1	474	480	544	1.82e-140	417	PAK1_RAT	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (Protein kinase MUK2) (p21-activated kinase 1) (PAK-1) (p68-PAK)	Rattus norvegicus (Rat)	actin cytoskeleton organization [GO:0030036]; amygdala development [GO:0021764]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration [GO:0016477]; cellular response to insulin stimulus [GO:0032869]; cellular response to starvation [GO:0009267]; cerebellum development [GO:0021549]; chromatin remodeling [GO:0006338]; dendrite development [GO:0016358]; dendritic spine development [GO:0060996]; DNA damage response [GO:0006974]; establishment of cell polarity [GO:0030010]; gamma-aminobutyric acid secretion, neurotransmission [GO:0061534]; glutamate secretion, neurotransmission [GO:0061535]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; intracellular signal transduction [GO:0035556]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; neuromuscular junction development [GO:0007528]; neuron projection morphogenesis [GO:0048812]; observational learning [GO:0098597]; positive regulation of axon extension [GO:0045773]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular associated smooth muscle cell proliferation [GO:1904707]; protein autophosphorylation [GO:0046777]; protein localization to cytoplasmic stress granule [GO:1903608]; protein phosphorylation [GO:0006468]; receptor clustering [GO:0043113]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axonogenesis [GO:0050770]; regulation of gene expression [GO:0010468]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of MAPK cascade [GO:0043408]; regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0150036]; response to hypoxia [GO:0001666]; small GTPase-mediated signal transduction [GO:0007264]; transmission of nerve impulse [GO:0019226]; wound healing [GO:0042060]	ATP binding [GO:0005524]; collagen binding [GO:0005518]; gamma-tubulin binding [GO:0043015]; identical protein binding [GO:0042802]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; small GTPase binding [GO:0031267]	actin filament [GO:0005884]; axon [GO:0030424]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; intercalated disc [GO:0014704]; lamellipodium [GO:0030027]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; Z disc [GO:0030018]	GO:0001666; GO:0001726; GO:0004672; GO:0004674; GO:0004709; GO:0005518; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005813; GO:0005829; GO:0005884; GO:0005886; GO:0005911; GO:0005925; GO:0006338; GO:0006468; GO:0006974; GO:0007264; GO:0007528; GO:0008284; GO:0009267; GO:0010468; GO:0010763; GO:0014069; GO:0014704; GO:0016358; GO:0016477; GO:0019226; GO:0019901; GO:0021549; GO:0021764; GO:0030010; GO:0030018; GO:0030027; GO:0030036; GO:0030335; GO:0030424; GO:0030425; GO:0030426; GO:0031267; GO:0031965; GO:0032587; GO:0032869; GO:0032956; GO:0032991; GO:0033138; GO:0033148; GO:0035556; GO:0042060; GO:0042802; GO:0043015; GO:0043113; GO:0043408; GO:0045773; GO:0046628; GO:0046777; GO:0048012; GO:0048754; GO:0048812; GO:0050770; GO:0051496; GO:0060244; GO:0060996; GO:0061052; GO:0061534; GO:0061535; GO:0090063; GO:0090314; GO:0098597; GO:0098793; GO:0098978; GO:0098982; GO:0106310; GO:0150036; GO:1900271; GO:1903608; GO:1904707; GO:1904754
GN018754	GN018754.1	Q08E52	50.6	474	469	544	3.63e-137	408	PAK1_BOVIN	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)	Bos taurus (Bovine)	actin cytoskeleton organization [GO:0030036]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration [GO:0016477]; cellular response to starvation [GO:0009267]; chromatin remodeling [GO:0006338]; DNA damage response [GO:0006974]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of microtubule nucleation [GO:0090063]; positive regulation of stress fiber assembly [GO:0051496]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of axonogenesis [GO:0050770]; regulation of MAPK cascade [GO:0043408]; wound healing [GO:0042060]	ATP binding [GO:0005524]; collagen binding [GO:0005518]; gamma-tubulin binding [GO:0043015]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell-cell junction [GO:0005911]; centrosome [GO:0005813]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	GO:0001726; GO:0004674; GO:0005518; GO:0005524; GO:0005654; GO:0005694; GO:0005737; GO:0005813; GO:0005886; GO:0005911; GO:0005925; GO:0006338; GO:0006974; GO:0009267; GO:0016477; GO:0030027; GO:0030036; GO:0030335; GO:0032587; GO:0032956; GO:0033148; GO:0042060; GO:0043015; GO:0043408; GO:0048754; GO:0050770; GO:0051496; GO:0060244; GO:0090063; GO:0106310; GO:1903608
GN018755	GN018755.1	Q921C5	43.9	817	809	820	7.09e-103	339	BICD2_MOUSE	Protein bicaudal D homolog 2 (Bic-D 2)	Mus musculus (Mouse)	centrosome localization [GO:0051642]; microtubule anchoring at microtubule organizing center [GO:0072393]; microtubule-based movement [GO:0007018]; minus-end-directed organelle transport along microtubule [GO:0072385]; protein localization to Golgi apparatus [GO:0034067]; regulation of microtubule cytoskeleton organization [GO:0070507]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	cytoskeletal adaptor activity [GO:0008093]; dynactin binding [GO:0034452]; dynein complex binding [GO:0070840]; dynein light intermediate chain binding [GO:0051959]; small GTPase binding [GO:0031267]	annulate lamellae [GO:0005642]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; plasma membrane [GO:0005886]	GO:0005635; GO:0005642; GO:0005643; GO:0005737; GO:0005794; GO:0005813; GO:0005829; GO:0005886; GO:0006890; GO:0007018; GO:0008093; GO:0031267; GO:0031410; GO:0034067; GO:0034452; GO:0051642; GO:0051959; GO:0070507; GO:0070840; GO:0072385; GO:0072393
GN018756	GN018756.1	Q3UX61	82.4	119	145	218	1.77e-63	196	NAA11_MOUSE	N-alpha-acetyltransferase 11 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog B) (NatA catalytic subunit Naa11)	Mus musculus (Mouse)	N-terminal protein amino acid acetylation [GO:0006474]	protein N-terminal-serine acetyltransferase activity [GO:1990189]; protein-N-terminal amino-acid acetyltransferase activity [GO:0004596]; protein-N-terminal-alanine acetyltransferase activity [GO:0008999]; protein-N-terminal-glutamate acetyltransferase activity [GO:1990190]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; NatA complex [GO:0031415]; nucleoplasm [GO:0005654]	GO:0004596; GO:0005654; GO:0005794; GO:0005813; GO:0005829; GO:0005929; GO:0006474; GO:0008999; GO:0031415; GO:0036064; GO:1990189; GO:1990190
GN018757	GN018757.1	Q5R5X3	47.2	1169	1004	1186	1.02e-97	337	PUM1_PONAB	Pumilio homolog 1	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	3'-UTR-mediated mRNA destabilization [GO:0061158]; adult locomotory behavior [GO:0008344]; miRNA processing [GO:0035196]; mRNA destabilization [GO:0061157]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; post-transcriptional gene silencing [GO:0016441]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell cycle [GO:0051726]; regulation of chromosome segregation [GO:0051983]; regulation of mRNA stability [GO:0043488]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]	miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; P-body [GO:0000932]	GO:0000932; GO:0003730; GO:0005737; GO:0005829; GO:0007283; GO:0008344; GO:0010608; GO:0016441; GO:0035196; GO:0035198; GO:0043488; GO:0048863; GO:0051726; GO:0051983; GO:0061157; GO:0061158; GO:1900246; GO:2000637
GN018758	GN018758.1	Q6NRK9	55.8	226	231	244	6.29e-95	280	CCNQ_XENLA	Cyclin-Q (Cyclin-related protein FAM58A)	Xenopus laevis (African clawed frog)	regulation of transcription by RNA polymerase II [GO:0006357]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]		GO:0006357; GO:0016538
GN018760	GN018760.1	P22680	32.2	488	490	504	6.41e-63	216	CP7A1_HUMAN	Cytochrome P450 7A1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cholesterol 7-alpha-monooxygenase) (EC 1.14.14.23)	Homo sapiens (Human)	bile acid biosynthetic process [GO:0006699]; cellular response to cholesterol [GO:0071397]; cellular response to glucose stimulus [GO:0071333]; cholesterol catabolic process [GO:0006707]; cholesterol homeostasis [GO:0042632]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of fatty acid biosynthetic process [GO:0045717]; positive regulation of cholesterol biosynthetic process [GO:0045542]; regulation of bile acid biosynthetic process [GO:0070857]; response to ethanol [GO:0045471]; sterol metabolic process [GO:0016125]	24S-hydroxycholesterol 7-alpha-hydroxylase activity [GO:0033782]; cholesterol 7-alpha-monooxygenase activity [GO:0008123]; heme binding [GO:0020037]; iron ion binding [GO:0005506]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	GO:0005506; GO:0005789; GO:0006699; GO:0006707; GO:0008123; GO:0016125; GO:0020037; GO:0032966; GO:0033782; GO:0042632; GO:0043231; GO:0045471; GO:0045542; GO:0045717; GO:0070857; GO:0071333; GO:0071397
GN018761	GN018761.1	L7N6F8	48.9	47	101	90	2.72e-09	52.8	DEP23_DERPT	Major mite allergen Der p 23 (Major house dust mite allergen Der p 23) (Major HDM allergen Der p 23) (Peritrophin-like protein Der p 23) (allergen Der p 23)	Dermatophagoides pteronyssinus (European house dust mite)		IgE binding [GO:0019863]	cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]	GO:0005576; GO:0005783; GO:0019863; GO:0031410
GN018762	GN018762.1	Q8IW92	47.1	601	627	636	4.74e-182	532	GLBL2_HUMAN	Beta-galactosidase-1-like protein 2 (EC 3.2.1.23)	Homo sapiens (Human)	galactose catabolic process [GO:0019388]	beta-galactosidase activity [GO:0004565]	vacuole [GO:0005773]	GO:0004565; GO:0005773; GO:0019388
GN018764	GN018764.1	O60381	42.3	310	317	514	8.29e-64	213	HBP1_HUMAN	HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1)	Homo sapiens (Human)	regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0003723; GO:0005634; GO:0006357; GO:0016607; GO:0051726
GN018765	GN018765.1	Q6NT16	41.0	385	511	456	7.01e-93	293	S18B1_HUMAN	MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) (Vesicular polyamine transporter) (VPAT)	Homo sapiens (Human)	serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; spermine transport [GO:0000296]	monoamine:proton antiporter activity [GO:0015311]; polyamine:proton antiporter activity [GO:0015312]; transmembrane transporter activity [GO:0022857]	secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]	GO:0000296; GO:0015311; GO:0015312; GO:0015848; GO:0022857; GO:0030667; GO:0030672; GO:0051610
GN018767	GN018767.1	Q9SZJ2	38.5	283	811	787	5.48e-53	201	GRDP2_ARATH	Glycine-rich domain-containing protein 2 (AtGRDP2)	Arabidopsis thaliana (Mouse-ear cress)	cellular response to osmotic stress [GO:0071470]; regulation of auxin mediated signaling pathway [GO:0010928]; regulation of photoperiodism, flowering [GO:2000028]		cytoplasm [GO:0005737]	GO:0005737; GO:0010928; GO:0071470; GO:2000028
GN018769	GN018769.1	Q6DCQ0	46.3	190	475	398	4.92e-38	146	P4R2B_XENLA	Serine/threonine-protein phosphatase 4 regulatory subunit 2-B	Xenopus laevis (African clawed frog)		protein phosphatase regulator activity [GO:0019888]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein phosphatase 4 complex [GO:0030289]	GO:0005634; GO:0005737; GO:0019888; GO:0030289
GN018772	GN018772.1	P26183	29.1	381	2418	376	5.25e-46	174	ACT_CRYPV	Actin (EC 3.6.4.-)	Cryptosporidium parvum		ATP hydrolysis activity [GO:0016887]	cytoskeleton [GO:0005856]	GO:0005856; GO:0016887
GN018773	GN018773.1	O70212	32.8	302	394	490	2.65e-41	155	5HT3A_CAVPO	5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor)	Cavia porcellus (Guinea pig)	monoatomic cation transport [GO:0006812]	extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]	plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synaptic vesicle membrane [GO:0030672]	GO:0004890; GO:0005230; GO:0005886; GO:0006812; GO:0030672; GO:0045211
GN018779	GN018779.1	Q5R8H3	50.4	246	236	246	1.22e-53	176	BAP31_PONAB	B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; protein localization to endoplasmic reticulum exit site [GO:0070973]		endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]	GO:0005789; GO:0006886; GO:0006888; GO:0033116; GO:0070973
GN018780	GN018780.1	Q86XH1	56.9	819	848	822	4.89e-272	777	DRC11_HUMAN	Dynein regulatory complex subunit 11 (IQ and AAA domain-containing protein 1)	Homo sapiens (Human)	cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]; microtubule severing [GO:0051013]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568]	axonemal nexin link [GO:0005931]; axoneme [GO:0005930]	GO:0003341; GO:0005524; GO:0005930; GO:0005931; GO:0008568; GO:0016887; GO:0030317; GO:0051013
GN018781	GN018781.1	Q2KJC3	43.0	107	224	717	4.91e-21	94.4	MPEG1_BOVIN	Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) (Perforin-2) (P-2) [Cleaved into: Macrophage-expressed gene 1 protein, processed form]	Bos taurus (Bovine)	antibacterial innate immune response [GO:0140367]; antigen processing and presentation of exogenous peptide antigen [GO:0002478]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; dendritic cell antigen processing and presentation [GO:0002468]	wide pore channel activity [GO:0022829]	cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagolysosome membrane [GO:0061474]	GO:0002468; GO:0002478; GO:0022829; GO:0030659; GO:0030670; GO:0031410; GO:0042590; GO:0042742; GO:0045335; GO:0050829; GO:0050830; GO:0061474; GO:0140367
GN018784	GN018784.1	Q2PZL6	29.9	874	979	4981	2.02e-92	327	FAT4_MOUSE	Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J)	Mus musculus (Mouse)	axonogenesis [GO:0007409]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell adhesion mediated by cadherin [GO:0044331]; cerebral cortex development [GO:0021987]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; epithelial cell differentiation [GO:0030855]; establishment of planar polarity [GO:0001736]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell-cell adhesion [GO:0007156]; inner ear receptor cell stereocilium organization [GO:0060122]; kidney development [GO:0001822]; nephron development [GO:0072006]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; plasma membrane [GO:0005886]	GO:0001658; GO:0001736; GO:0001822; GO:0003007; GO:0005509; GO:0005886; GO:0005912; GO:0007009; GO:0007156; GO:0007157; GO:0007219; GO:0007409; GO:0008543; GO:0021987; GO:0022008; GO:0030855; GO:0035329; GO:0043931; GO:0044331; GO:0045177; GO:0048565; GO:0060122; GO:0072006; GO:0072137; GO:0072307
GN018787	GN018787.1	Q7JQD3	53.9	371	386	367	3.91e-131	383	GELS1_LUMTE	Gelsolin-like protein 1 (Actin-modulator) (EWAM) (EWAM-P1)	Lumbricus terrestris (Common earthworm)	actin filament capping [GO:0051693]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin nucleation [GO:0045010]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; actin filament severing activity [GO:0003789]; calcium ion binding [GO:0005509]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]	GO:0003779; GO:0003789; GO:0005509; GO:0005737; GO:0015629; GO:0030041; GO:0045010; GO:0051014; GO:0051015; GO:0051693
GN018788	GN018788.1	Q1LZ75	67.5	197	320	294	5.33e-94	283	ERCC1_BOVIN	DNA excision repair protein ERCC-1	Bos taurus (Bovine)	double-strand break repair [GO:0006302]; mitotic recombination [GO:0006312]; negative regulation of telomere maintenance [GO:0032205]; nucleotide-excision repair [GO:0006289]; response to oxidative stress [GO:0006979]; telomere maintenance [GO:0000723]; UV-damage excision repair [GO:0070914]	damaged DNA binding [GO:0003684]; single-stranded DNA binding [GO:0003697]	chromosome, telomeric region [GO:0000781]; ERCC4-ERCC1 complex [GO:0070522]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 1 complex [GO:0000110]; nucleus [GO:0005634]	GO:0000109; GO:0000110; GO:0000723; GO:0000781; GO:0003684; GO:0003697; GO:0005634; GO:0006289; GO:0006302; GO:0006312; GO:0006979; GO:0032205; GO:0070522; GO:0070914
GN018789	GN018789.1	Q5T653	45.5	220	247	305	1.67e-56	185	RM02_HUMAN	Large ribosomal subunit protein uL2m (39S ribosomal protein L2, mitochondrial) (L2mt) (MRP-L2)	Homo sapiens (Human)	mitochondrial translation [GO:0032543]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003723; GO:0003735; GO:0005739; GO:0005743; GO:0005762; GO:0032543
GN018793	GN018793.1	Q3UVX5	26.0	496	1340	1203	4.15e-41	169	GRM5_MOUSE	Metabotropic glutamate receptor 5 (mGluR5)	Mus musculus (Mouse)	associative learning [GO:0008306]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; conditioned place preference [GO:1990708]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of excitatory postsynaptic potential [GO:0090394]; operant conditioning [GO:0035106]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cellular response to hypoxia [GO:1900039]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of sensory perception of pain [GO:1904058]; protein localization to nuclear inner membrane [GO:0036228]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of long-term synaptic depression [GO:1900452]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of hot stimulus [GO:0062036]; synapse organization [GO:0050808]; temperature homeostasis [GO:0001659]	A2A adenosine receptor binding [GO:0031687]; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; PLC activating G protein-coupled glutamate receptor activity [GO:0001639]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase binding [GO:1990782]	astrocyte projection [GO:0097449]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0001639; GO:0001640; GO:0001659; GO:0002029; GO:0004930; GO:0005637; GO:0005737; GO:0005886; GO:0006355; GO:0006468; GO:0007204; GO:0007206; GO:0007216; GO:0007268; GO:0007611; GO:0007612; GO:0007626; GO:0008066; GO:0008306; GO:0030296; GO:0030425; GO:0031687; GO:0033603; GO:0035106; GO:0036228; GO:0042802; GO:0043005; GO:0043025; GO:0043197; GO:0043198; GO:0043410; GO:0044309; GO:0045211; GO:0048169; GO:0048170; GO:0050804; GO:0050808; GO:0050850; GO:0050890; GO:0051966; GO:0061002; GO:0062036; GO:0090394; GO:0097449; GO:0098685; GO:0098839; GO:0098978; GO:0099530; GO:1900039; GO:1900452; GO:1904058; GO:1904646; GO:1990708; GO:1990782; GO:2000179
GN018794	GN018794.1	E7F654	29.0	575	1160	713	1.46e-61	228	NOL9_DANRE	Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9)	Danio rerio (Zebrafish) (Brachydanio rerio)	cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000448]; definitive hemopoiesis [GO:0060216]; digestive tract development [GO:0048565]; exocrine pancreas development [GO:0031017]; liver development [GO:0001889]; pancreas morphogenesis [GO:0061113]; rRNA processing [GO:0006364]	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [GO:0051736]; polynucleotide 5'-hydroxyl-kinase activity [GO:0051731]	nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0000448; GO:0001889; GO:0005634; GO:0005730; GO:0006364; GO:0031017; GO:0046404; GO:0048565; GO:0051731; GO:0051736; GO:0060216; GO:0061113
GN018795	GN018795.1	Q6R6I7	49.0	51	164	758	1.25e-09	59.3	RXFP1_MOUSE	Relaxin receptor 1 (Leucine-rich repeat-containing G protein-coupled receptor 7) (Relaxin family peptide receptor 1)	Mus musculus (Mouse)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; hormone-mediated signaling pathway [GO:0009755]; lung connective tissue development [GO:0060427]; nipple morphogenesis [GO:0060658]; parturition [GO:0007567]	G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]	plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007188; GO:0007189; GO:0007567; GO:0008528; GO:0009755; GO:0030154; GO:0030198; GO:0042562; GO:0060427; GO:0060658
GN018796	GN018796.1	Q9Y264	42.1	126	128	503	1.07e-22	95.1	ANGP4_HUMAN	Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3)	Homo sapiens (Human)	angiogenesis [GO:0001525]; blood coagulation [GO:0007596]; cellular response to hypoxia [GO:0071456]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; signal transduction [GO:0007165]; Tie signaling pathway [GO:0048014]	receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0001525; GO:0005576; GO:0007165; GO:0007596; GO:0010595; GO:0016525; GO:0030297; GO:0030971; GO:0031012; GO:0043066; GO:0043536; GO:0043537; GO:0045766; GO:0048014; GO:0048018; GO:0050731; GO:0071456
GN018799	GN018799.1	Q9U8W7	44.8	125	128	316	5.37e-28	107	TL5B_TACTR	Techylectin-5B	Tachypleus tridentatus (Japanese horseshoe crab)	cell-cell adhesion [GO:0098609]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]	carbohydrate binding [GO:0030246]; extracellular matrix structural constituent [GO:0005201]; protein-macromolecule adaptor activity [GO:0030674]	fibrinogen complex [GO:0005577]	GO:0005201; GO:0005577; GO:0030246; GO:0030674; GO:0034116; GO:0098609
GN018802	GN018802.1	Q6DFC2	57.1	471	471	496	1.17e-153	449	CCD77_XENLA	Coiled-coil domain-containing protein 77	Xenopus laevis (African clawed frog)			centrosome [GO:0005813]	GO:0005813
GN018804	GN018804.1	D3YXG0	45.4	335	649	5634	8.86e-100	338	HMCN1_MOUSE	Hemicentin-1 (Fibulin-6) (FIBL-6)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]; response to bacterium [GO:0009617]	calcium ion binding [GO:0005509]; cell adhesion mediator activity [GO:0098631]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; muscle tendon junction [GO:0005927]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005509; GO:0005576; GO:0005604; GO:0005737; GO:0005886; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0009617; GO:0030036; GO:0030054; GO:0031012; GO:0032154; GO:0070161; GO:0071711; GO:0098631; GO:0140144
GN018810	GN018810.1	Q9VLN1	76.0	304	307	317	8.98e-181	504	WDR82_DROME	WD repeat-containing protein 82	Drosophila melanogaster (Fruit fly)	chromatin remodeling [GO:0006338]; heart development [GO:0007507]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; nuclear RNA surveillance [GO:0071027]	chromatin binding [GO:0003682]	histone methyltransferase complex [GO:0035097]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]	GO:0003682; GO:0005634; GO:0006338; GO:0007507; GO:0032785; GO:0035097; GO:0048188; GO:0071027
GN018825	GN018825.1	P79132	39.2	125	132	178	8.78e-23	90.9	CAV1_BOVIN	Caveolin-1	Bos taurus (Bovine)	caveola assembly [GO:0070836]; cell differentiation [GO:0030154]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of transcription by RNA polymerase II [GO:0000122]; receptor internalization [GO:0031623]; regulation of cytosolic calcium ion concentration [GO:0051480]; T cell costimulation [GO:0031295]	ATPase binding [GO:0051117]; molecular adaptor activity [GO:0060090]; oxysterol binding [GO:0008142]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]	caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	GO:0000122; GO:0000139; GO:0001937; GO:0005737; GO:0005768; GO:0005783; GO:0005794; GO:0005886; GO:0005901; GO:0008142; GO:0019901; GO:0030154; GO:0031295; GO:0031410; GO:0031623; GO:0042383; GO:0044325; GO:0045121; GO:0048471; GO:0051117; GO:0051480; GO:0060090; GO:0070836; GO:0090090
GN018827	GN018827.1	O02373	68.0	469	479	476	2.08e-239	666	UGDH_DROME	UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (Protein sugarless) (Protein suppenkasper)	Drosophila melanogaster (Fruit fly)	chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; epithelial cell migration, open tracheal system [GO:0007427]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; mesoderm migration involved in gastrulation [GO:0007509]; segment polarity determination [GO:0007367]; UDP-glucuronate biosynthetic process [GO:0006065]	NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003979; GO:0005634; GO:0005737; GO:0005829; GO:0006024; GO:0006065; GO:0007367; GO:0007427; GO:0007509; GO:0008543; GO:0015012; GO:0050650; GO:0051287
GN018829	GN018829.1	Q00PJ9	41.1	129	132	178	1.54e-29	108	CAV1_ATEAB	Caveolin-1	Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog)	caveola assembly [GO:0070836]; cell differentiation [GO:0030154]; negative regulation of endothelial cell proliferation [GO:0001937]; receptor internalization [GO:0031623]; regulation of cytosolic calcium ion concentration [GO:0051480]; T cell costimulation [GO:0031295]	molecular adaptor activity [GO:0060090]; oxysterol binding [GO:0008142]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]	caveola [GO:0005901]; cytoplasm [GO:0005737]; endosome [GO:0005768]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; membrane raft [GO:0045121]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]	GO:0000139; GO:0001937; GO:0005737; GO:0005768; GO:0005886; GO:0005901; GO:0005925; GO:0008142; GO:0019901; GO:0030154; GO:0031295; GO:0031623; GO:0042383; GO:0044325; GO:0045121; GO:0048471; GO:0051480; GO:0060090; GO:0070836
GN018830	GN018830.1	Q6XUX0	31.3	230	1011	930	1.91e-22	107	DUSTY_CHICK	Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5)	Gallus gallus (Chicken)	cellular response to fibroblast growth factor stimulus [GO:0044344]; negative regulation of apoptotic process [GO:0043066]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004712; GO:0004713; GO:0005524; GO:0005737; GO:0005886; GO:0016323; GO:0016324; GO:0043066; GO:0044344; GO:0045743; GO:0070161; GO:0070374; GO:0106310
GN018831	GN018831.1	P21837	32.1	471	552	550	2.92e-55	198	CRYS_DICDI	Crystal protein	Dictyostelium discoideum (Social amoeba)	endocytosis [GO:0006897]; mitotic cytokinesis [GO:0000281]; sorocarp development [GO:0030587]	hydrolase activity, acting on ester bonds [GO:0016788]	early phagosome [GO:0032009]; esterosome membrane [GO:0033118]; extracellular matrix [GO:0031012]; lysosome [GO:0005764]	GO:0000281; GO:0005764; GO:0006897; GO:0016788; GO:0030587; GO:0031012; GO:0032009; GO:0033118
GN018839	GN018839.1	Q9Y6I9	42.0	200	343	313	2.56e-45	160	TX264_HUMAN	Testis-expressed protein 264 (Putative secreted protein Zsig11)	Homo sapiens (Human)	protein-DNA covalent cross-linking repair [GO:0106300]; reticulophagy [GO:0061709]	signaling receptor activity [GO:0038023]	autophagosome membrane [GO:0000421]; chromosome [GO:0005694]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]; replication fork [GO:0005657]	GO:0000421; GO:0005576; GO:0005634; GO:0005657; GO:0005694; GO:0005783; GO:0005789; GO:0005829; GO:0031093; GO:0038023; GO:0061709; GO:0106300
GN018840	GN018840.1	Q0E908	34.3	172	461	818	5.59e-17	87.4	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN018842	GN018842.1	Q0P4F7	26.0	574	545	606	1.14e-39	155	ACSF2_DANRE	Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2)	Danio rerio (Zebrafish) (Brachydanio rerio)		medium-chain fatty acid-CoA ligase activity [GO:0031956]	mitochondrion [GO:0005739]	GO:0005739; GO:0031956
GN018844	GN018844.1	Q0P4F7	28.3	566	544	606	9.34e-48	178	ACSF2_DANRE	Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2)	Danio rerio (Zebrafish) (Brachydanio rerio)		medium-chain fatty acid-CoA ligase activity [GO:0031956]	mitochondrion [GO:0005739]	GO:0005739; GO:0031956
GN018846	GN018846.1	Q17QJ1	27.5	578	547	615	1.81e-45	172	ACSF2_BOVIN	Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2)	Bos taurus (Bovine)		medium-chain fatty acid-CoA ligase activity [GO:0031956]	mitochondrion [GO:0005739]	GO:0005739; GO:0031956
GN018847	GN018847.1	P94547	26.0	219	326	560	2.17e-11	68.2	LCFA_BACSU	Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Long-chain acyl-CoA synthetase)	Bacillus subtilis (strain 168)		CoA-ligase activity [GO:0016405]; long-chain fatty acid-CoA ligase activity [GO:0004467]		GO:0004467; GO:0016405
GN018861	GN018861.1	Q25386	24.1	270	1201	916	2.26e-21	104	SCRB_LIMPO	Beta-scruin	Limulus polyphemus (Atlantic horseshoe crab)				
GN018862	GN018862.1	Q58CN9	52.3	323	340	392	1.03e-122	361	NAPEP_BOVIN	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54)	Bos taurus (Bovine)	host-mediated modulation of intestinal microbiota composition [GO:0048874]; N-acylethanolamine metabolic process [GO:0070291]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of inflammatory response [GO:0050729]; temperature homeostasis [GO:0001659]	N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]	GO:0000139; GO:0001659; GO:0005635; GO:0005654; GO:0005737; GO:0005769; GO:0005794; GO:0008270; GO:0031901; GO:0043005; GO:0043025; GO:0048874; GO:0050729; GO:0070290; GO:0070291; GO:0070292; GO:0090336
GN018863	GN018863.1	Q8N0W4	34.5	501	492	816	3.33e-71	244	NLGNX_HUMAN	Neuroligin-4, X-linked (Neuroligin X) (HNLX)	Homo sapiens (Human)	adult behavior [GO:0030534]; brainstem development [GO:0003360]; cell-cell junction organization [GO:0045216]; cerebellum development [GO:0021549]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of excitatory postsynaptic potential [GO:0090394]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; organ growth [GO:0035265]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; regulation of synapse assembly [GO:0051963]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; vocalization behavior [GO:0071625]	cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; chloride ion binding [GO:0031404]; neurexin family protein binding [GO:0042043]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]	asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic specialization membrane [GO:0099634]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]	GO:0003360; GO:0005886; GO:0007158; GO:0007416; GO:0007612; GO:0009986; GO:0016020; GO:0021549; GO:0030182; GO:0030425; GO:0030534; GO:0031404; GO:0035176; GO:0035265; GO:0042043; GO:0042803; GO:0043197; GO:0045202; GO:0045216; GO:0050804; GO:0050808; GO:0050839; GO:0051963; GO:0060076; GO:0071625; GO:0090394; GO:0097105; GO:0097110; GO:0098631; GO:0098839; GO:0098978; GO:0098982; GO:0098983; GO:0098985; GO:0099054; GO:0099634
GN018864	GN018864.1	Q2KIA6	54.3	687	644	683	2.60e-211	609	PRPF3_BOVIN	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3)	Bos taurus (Bovine)	mRNA splicing, via spliceosome [GO:0000398]; spliceosomal tri-snRNP complex assembly [GO:0000244]		nuclear speck [GO:0016607]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	GO:0000244; GO:0000398; GO:0005634; GO:0016607; GO:0046540
GN018869	GN018869.1	Q9LVX0	28.5	221	706	537	5.48e-21	100	ARI3_ARATH	Probable E3 ubiquitin-protein ligase ARI3 (EC 2.3.2.31) (ARIADNE-like protein ARI3) (Protein ariadne homolog 3) (RING-type E3 ubiquitin transferase ARI3)	Arabidopsis thaliana (Mouse-ear cress)	protein ubiquitination [GO:0016567]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005634; GO:0008270; GO:0016567; GO:0031624; GO:0061630
GN018873	GN018873.1	Q63505	27.6	1090	942	2148	4.24e-88	313	TF3C1_RAT	General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha)	Rattus norvegicus (Rat)	5S class rRNA transcription by RNA polymerase III [GO:0042791]; transcription initiation at RNA polymerase III promoter [GO:0006384]	DNA binding [GO:0003677]; RNA polymerase III general transcription initiation factor activity [GO:0000995]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; transcription factor TFIIIC complex [GO:0000127]	GO:0000127; GO:0000995; GO:0003677; GO:0005634; GO:0005654; GO:0006384; GO:0042791; GO:1990904
GN018878	GN018878.1	E9PVD3	35.9	117	164	3291	1.89e-09	58.9	PCD16_MOUSE	Protocadherin-16 (Protein Dchs1) (Protein dachsous homolog 1)	Mus musculus (Mouse)	anatomical structure morphogenesis [GO:0009653]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell migration [GO:0016477]; cell migration involved in endocardial cushion formation [GO:0003273]; cell-cell adhesion [GO:0098609]; cochlea development [GO:0090102]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; establishment of planar polarity [GO:0001736]; gene expression [GO:0010467]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell-cell adhesion [GO:0007156]; kidney development [GO:0001822]; mitral valve development [GO:0003174]; mitral valve formation [GO:0003192]; mitral valve morphogenesis [GO:0003183]; nephron development [GO:0072006]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; pattern specification process [GO:0007389]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]; septin cytoskeleton organization [GO:0032185]	beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	apical part of cell [GO:0045177]; catenin complex [GO:0016342]	GO:0001658; GO:0001736; GO:0001822; GO:0003007; GO:0003174; GO:0003183; GO:0003192; GO:0003273; GO:0005509; GO:0007156; GO:0007157; GO:0007389; GO:0008013; GO:0009653; GO:0010467; GO:0016342; GO:0016477; GO:0021915; GO:0022008; GO:0032185; GO:0035329; GO:0036342; GO:0043931; GO:0045177; GO:0045296; GO:0048565; GO:0072006; GO:0072137; GO:0072659; GO:0090102; GO:0098609
GN018883	GN018883.1	Q8IXR9	26.9	808	819	622	1.13e-62	225	CL056_HUMAN	Uncharacterized protein C12orf56	Homo sapiens (Human)				
GN018886	GN018886.1	Q5AXT5	34.0	197	221	745	2.92e-26	109	PIF1_EMENI	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]	GO:0000723; GO:0003697; GO:0005524; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0043139; GO:0043596; GO:0071932
GN018887	GN018887.1	Q8BZ20	32.7	196	394	711	1.61e-22	103	PAR12_MOUSE	Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1)	Mus musculus (Mouse)	cell-cell adhesion mediated by cadherin [GO:0044331]; protein auto-ADP-ribosylation [GO:0070213]; transepithelial transport [GO:0070633]	metal ion binding [GO:0046872]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-cysteine ADP-ribosyltransferase activity [GO:0140803]	cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]	GO:0003950; GO:0005634; GO:0005802; GO:0010494; GO:0044331; GO:0046872; GO:0070213; GO:0070633; GO:0140803; GO:0140806; GO:1990404
GN018895	GN018895.1	O43704	33.2	271	317	296	4.00e-37	137	ST1B1_HUMAN	Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase)	Homo sapiens (Human)	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004062; GO:0005737; GO:0005829; GO:0006068; GO:0006576; GO:0006805; GO:0008146; GO:0009812; GO:0018958; GO:0030855; GO:0042403; GO:0050427; GO:0051923
GN018899	GN018899.1	Q9ZQ47	39.1	340	691	819	7.39e-53	199	GRDP1_ARATH	Glycine-rich domain-containing protein 1 (AtGRDP1)	Arabidopsis thaliana (Mouse-ear cress)	cellular response to osmotic stress [GO:0071470]; regulation of abscisic acid-activated signaling pathway [GO:0009787]; response to osmotic stress [GO:0006970]		cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005737; GO:0005886; GO:0006970; GO:0009787; GO:0071470
GN018901	GN018901.1	Q3B7H1	54.1	170	189	213	1.52e-65	203	GALD1_DANRE	Glutamine amidotransferase-like class 1 domain-containing protein 1 (Ferry endosomal RAB5 effector complex subunit 5) (Fy-5) (Parkinson disease 7 domain-containing protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)		glyoxalase III activity [GO:0019172]	early endosome [GO:0005769]; extracellular region [GO:0005576]	GO:0005576; GO:0005769; GO:0019172
GN018902	GN018902.1	P86952	34.9	298	740	456	6.81e-39	153	TYRO_PINMA	Tyrosinase-like protein (Tyrosinase-2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN018903	GN018903.1	Q9H334	42.5	532	995	677	2.15e-86	295	FOXP1_HUMAN	Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH)	Homo sapiens (Human)	cellular response to tumor necrosis factor [GO:0071356]; DNA damage response [GO:0006974]; endothelial cell activation [GO:0042118]; macrophage activation [GO:0042116]; monocyte activation [GO:0042117]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]; osteoclast development [GO:0036035]; osteoclast differentiation [GO:0030316]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of interleukin-21 production [GO:0032745]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of defense response to bacterium [GO:1900424]; regulation of endothelial tube morphogenesis [GO:1901509]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-1 beta production [GO:0032651]; regulation of interleukin-12 production [GO:0032655]; regulation of macrophage colony-stimulating factor production [GO:1901256]; regulation of monocyte differentiation [GO:0045655]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tumor necrosis factor production [GO:0032680]; response to lipopolysaccharide [GO:0032496]; response to testosterone [GO:0033574]; striatum development [GO:0021756]; T follicular helper cell differentiation [GO:0061470]	core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; nuclear androgen receptor binding [GO:0050681]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000785; GO:0000978; GO:0000981; GO:0001046; GO:0001227; GO:0002903; GO:0005634; GO:0005654; GO:0005667; GO:0006357; GO:0006974; GO:0010468; GO:0010595; GO:0010629; GO:0021756; GO:0030316; GO:0032496; GO:0032651; GO:0032655; GO:0032680; GO:0032745; GO:0033574; GO:0036035; GO:0042116; GO:0042117; GO:0042118; GO:0042802; GO:0045655; GO:0045892; GO:0048661; GO:0050681; GO:0050727; GO:0050861; GO:0060766; GO:0061052; GO:0061470; GO:0071356; GO:1900424; GO:1901256; GO:1901300; GO:1901509; GO:1990837; GO:2000341
GN018904	GN018904.1	Q9HDC9	36.8	321	412	416	7.64e-53	184	APMAP_HUMAN	Adipocyte plasma membrane-associated protein (Protein BSCv)	Homo sapiens (Human)		arylesterase activity [GO:0004064]	cell surface [GO:0009986]; membrane [GO:0016020]	GO:0004064; GO:0009986; GO:0016020
GN018905	GN018905.1	A5YVV0	31.4	668	674	661	8.94e-90	296	LAC3_ANOGA	Multicopper oxidase 3 (AgMCO3) (EC 1.10.3.2) (Laccase-3)	Anopheles gambiae (African malaria mosquito)		copper ion binding [GO:0005507]; hydroquinone:oxygen oxidoreductase activity [GO:0052716]	extracellular region [GO:0005576]	GO:0005507; GO:0005576; GO:0052716
GN018907	GN018907.1	Q28986	33.3	99	123	103	1.03e-11	60.1	CYTA5_PIG	Cystatin-A5 (Stefin-A5)	Sus scrofa (Pig)		cysteine-type endopeptidase inhibitor activity [GO:0004869]	cytosol [GO:0005829]	GO:0004869; GO:0005829
GN018909	GN018909.1	A5YVV0	31.5	612	695	661	4.87e-84	281	LAC3_ANOGA	Multicopper oxidase 3 (AgMCO3) (EC 1.10.3.2) (Laccase-3)	Anopheles gambiae (African malaria mosquito)		copper ion binding [GO:0005507]; hydroquinone:oxygen oxidoreductase activity [GO:0052716]	extracellular region [GO:0005576]	GO:0005507; GO:0005576; GO:0052716
GN018910	GN018910.1	Q9ESJ4	40.7	388	753	714	7.73e-85	286	SPN90_MOUSE	NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (VIP54) (90 kDa N-WASP-interacting protein) (90 kDa SH3 protein interacting with Nck) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-binding protein) (N-WASP-binding protein)	Mus musculus (Mouse)	endocytosis [GO:0006897]; positive regulation of neuron projection development [GO:0010976]; regulation of postsynapse assembly [GO:0150052]	Arp2/3 complex binding [GO:0071933]	COP9 signalosome [GO:0008180]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	GO:0005654; GO:0005886; GO:0006897; GO:0008180; GO:0010976; GO:0071933; GO:0098794; GO:0098978; GO:0150052
GN018912	GN018912.1	Q3SZJ4	54.8	241	237	329	5.04e-83	253	PTGR1_BOVIN	Prostaglandin reductase 1 (PRG-1) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (Dithiolethione-inducible gene 1 protein) (D3T-inducible gene 1 protein) (DIG-1) (Leukotriene B4 12-hydroxydehydrogenase) (NAD(P)H-dependent alkenal/one oxidoreductase) (EC 1.3.1.74)	Bos taurus (Bovine)	leukotriene B4 metabolic process [GO:0036102]; lipoxin A4 metabolic process [GO:2001302]; prostaglandin metabolic process [GO:0006693]	13-lipoxin reductase activity [GO:0036185]; 15-oxoprostaglandin 13-reductase [NAD(P)+] activity [GO:0047522]; 2-alkenal reductase (NADPH) activity [GO:0035798]; leukotriene B4 12-hydroxy dehydrogenase activity [GO:0097257]	cytoplasm [GO:0005737]	GO:0005737; GO:0006693; GO:0035798; GO:0036102; GO:0036185; GO:0047522; GO:0097257; GO:2001302
GN018915	GN018915.1	Q8VHZ7	65.7	289	300	291	4.75e-140	399	IMP4_MOUSE	U3 small nucleolar ribonucleoprotein protein IMP4 (U3 snoRNP protein IMP4)	Mus musculus (Mouse)	ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	rRNA primary transcript binding [GO:0042134]; snoRNA binding [GO:0030515]	fibrillar center [GO:0001650]; Mpp10 complex [GO:0034457]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome [GO:0030684]; small-subunit processome [GO:0032040]	GO:0001650; GO:0005654; GO:0005730; GO:0006364; GO:0030515; GO:0030684; GO:0032040; GO:0034457; GO:0042134; GO:0042274
GN018916	GN018916.1	Q66H43	29.6	169	208	360	2.01e-11	65.5	BORC6_RAT	BLOC-1-related complex subunit 6	Rattus norvegicus (Rat)	lysosome localization [GO:0032418]	identical protein binding [GO:0042802]	BORC complex [GO:0099078]; lysosomal membrane [GO:0005765]	GO:0005765; GO:0032418; GO:0042802; GO:0099078
GN018917	GN018917.1	Q9Z2F6	34.8	178	336	448	1.68e-18	89.4	BCL3_MOUSE	B-cell lymphoma 3 protein homolog (BCL-3)	Mus musculus (Mouse)	antimicrobial humoral response [GO:0019730]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of type II interferon production [GO:0032729]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to UV-C [GO:0010225]; response to virus [GO:0009615]; spleen development [GO:0048536]; T-helper 1 type immune response [GO:0042088]; T-helper 2 cell differentiation [GO:0045064]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	Bcl3-Bcl10 complex [GO:0032996]; Bcl3/NF-kappaB2 complex [GO:0033257]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	GO:0002268; GO:0002315; GO:0002455; GO:0002467; GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006606; GO:0006974; GO:0007249; GO:0009615; GO:0010225; GO:0019730; GO:0030198; GO:0030330; GO:0030496; GO:0030674; GO:0032717; GO:0032720; GO:0032729; GO:0032733; GO:0032991; GO:0032996; GO:0033257; GO:0036064; GO:0042088; GO:0042742; GO:0042771; GO:0042826; GO:0042832; GO:0042981; GO:0043066; GO:0045064; GO:0045727; GO:0045892; GO:0045893; GO:0045944; GO:0046426; GO:0048471; GO:0048536; GO:0140297; GO:1901222; GO:1901223
GN018918	GN018918.1	P41252	60.7	1269	1277	1262	0.0	1555	SYIC_HUMAN	Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)	Homo sapiens (Human)	isoleucyl-tRNA aminoacylation [GO:0006428]; osteoblast differentiation [GO:0001649]; tRNA aminoacylation for protein translation [GO:0006418]	aminoacyl-tRNA deacylase activity [GO:0002161]; ATP binding [GO:0005524]; GTPase binding [GO:0051020]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0000049; GO:0001649; GO:0002161; GO:0004822; GO:0005524; GO:0005737; GO:0005829; GO:0006418; GO:0006428; GO:0016020; GO:0017101; GO:0051020; GO:0070062
GN018919	GN018919.1	A5D6U8	34.5	420	517	443	6.05e-68	228	ACP7_DANRE	Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form)	Danio rerio (Zebrafish) (Brachydanio rerio)		acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872]	extracellular region [GO:0005576]	GO:0003993; GO:0005576; GO:0046872
GN018932	GN018932.1	Q9D0L7	25.1	259	620	306	4.87e-11	67.8	ARM10_MOUSE	Armadillo repeat-containing protein 10	Mus musculus (Mouse)	axonal transport of mitochondrion [GO:0019896]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of growth rate [GO:0040010]	DNA binding domain binding [GO:0050692]; p53 binding [GO:0002039]	axon cytoplasm [GO:1904115]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0002039; GO:0005739; GO:0005741; GO:0005783; GO:0005789; GO:0019896; GO:0040010; GO:0043066; GO:0050692; GO:1902254; GO:1904115
GN018933	GN018933.1	Q7ZX21	61.5	65	66	513	1.48e-15	72.0	OTU5A_XENLA	OTU domain-containing protein 5-A (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)	Xenopus laevis (African clawed frog)	cell differentiation [GO:0030154]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organismal process [GO:0051241]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of cytokine production [GO:0001817]; regulation of immune response [GO:0050776]; response to lipopolysaccharide [GO:0032496]	cysteine-type deubiquitinase activity [GO:0004843]; K63-linked deubiquitinase activity [GO:0061578]		GO:0001817; GO:0004843; GO:0010629; GO:0030154; GO:0032496; GO:0050776; GO:0051241; GO:0061578; GO:0070536; GO:0071108; GO:0090090; GO:1904263; GO:1904515
GN018934	GN018934.1	Q3U2S4	65.5	84	86	566	2.43e-36	131	OTUD5_MOUSE	OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)	Mus musculus (Mouse)	CD8-positive, alpha-beta T cell differentiation [GO:0043374]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of interleukin-17 production [GO:0032700]; neural crest cell differentiation [GO:0014033]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of immune response [GO:0050776]; regulation of protein stability [GO:0031647]; regulation of T-helper 17 type immune response [GO:2000316]; response to lipopolysaccharide [GO:0032496]; T-helper 17 cell lineage commitment [GO:0072540]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]	nucleus [GO:0005634]	GO:0004843; GO:0005634; GO:0014033; GO:0016579; GO:0031647; GO:0032496; GO:0032700; GO:0043161; GO:0043374; GO:0050776; GO:0061578; GO:0070536; GO:0071108; GO:0072540; GO:0090090; GO:0101005; GO:1904263; GO:1904515; GO:1990380; GO:2000316
GN018938	GN018938.1	Q66H61	70.0	373	373	775	1.00e-183	531	SYQ_RAT	Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS)	Rattus norvegicus (Rat)	brain development [GO:0007420]; glutaminyl-tRNA aminoacylation [GO:0006425]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stress-activated MAPK cascade [GO:0032873]	ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]	GO:0004819; GO:0004860; GO:0005524; GO:0005737; GO:0005829; GO:0006425; GO:0007420; GO:0017101; GO:0019901; GO:0032873; GO:0032991; GO:0045892; GO:2001234
GN018939	GN018939.1	Q3MHH4	56.3	206	207	775	2.71e-78	252	SYQ_BOVIN	Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS)	Bos taurus (Bovine)	brain development [GO:0007420]; glutaminyl-tRNA aminoacylation [GO:0006425]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stress-activated MAPK cascade [GO:0032873]	ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004819; GO:0004860; GO:0005524; GO:0005737; GO:0005829; GO:0006425; GO:0007420; GO:0017101; GO:0019901; GO:0032873; GO:0045892; GO:2001234
GN018940	GN018940.1	Q9V5N8	34.5	719	785	3579	2.09e-99	342	STAN_DROME	Protocadherin-like wing polarity protein stan (Protein flamingo) (Protein starry night)	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion [GO:0016339]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion mediated by cadherin [GO:0044331]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; homophilic cell-cell adhesion [GO:0007156]; morphogenesis of a polarized epithelium [GO:0001738]; mushroom body development [GO:0016319]; ommatidial rotation [GO:0016318]; positive regulation of axon extension [GO:0045773]; positive regulation of axon guidance [GO:1902669]; R3/R4 development [GO:0048057]; regulation of axonogenesis [GO:0050770]; regulation of synapse assembly [GO:0051963]; regulation of tube length, open tracheal system [GO:0035159]; segment polarity determination [GO:0007367]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001736; GO:0001737; GO:0001738; GO:0004888; GO:0004930; GO:0005509; GO:0005886; GO:0005911; GO:0005912; GO:0007156; GO:0007166; GO:0007367; GO:0007409; GO:0007411; GO:0016020; GO:0016318; GO:0016319; GO:0016324; GO:0016339; GO:0016358; GO:0035159; GO:0042067; GO:0044331; GO:0045773; GO:0048057; GO:0048813; GO:0050770; GO:0050839; GO:0051963; GO:0070593; GO:1902669
GN018941	GN018941.1	Q9I928	41.9	129	287	179	2.04e-16	78.6	FUCL4_ANGJA	Fucolectin-4	Anguilla japonica (Japanese eel)	regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; fucose binding [GO:0042806]	extracellular region [GO:0005576]	GO:0001868; GO:0005509; GO:0005576; GO:0010185; GO:0030246; GO:0042806; GO:0045088
GN018944	GN018944.1	Q9XWB9	35.8	120	253	320	2.54e-15	77.4	BAT36_CAEEL	BTB and MATH domain-containing protein 36	Caenorhabditis elegans				
GN018949	GN018949.1	Q9UP83	60.2	805	807	860	0.0	932	COG5_HUMAN	Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1)	Homo sapiens (Human)	Golgi organization [GO:0007030]; inter-Golgi cisterna vesicle-mediated transport [GO:0048219]; intra-Golgi vesicle-mediated transport [GO:0006891]; retrograde transport, vesicle recycling within Golgi [GO:0000301]		COG complex [GO:0017119]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588]	GO:0000139; GO:0000301; GO:0005794; GO:0005829; GO:0006891; GO:0007030; GO:0016020; GO:0017119; GO:0032588; GO:0048219
GN018950	GN018950.1	O95620	57.5	268	286	317	1.43e-110	325	DUS4L_HUMAN	tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (EC 1.3.1.90) (pp35) (tRNA-dihydrouridine synthase 4-like)	Homo sapiens (Human)	tRNA dihydrouridine synthesis [GO:0002943]	flavin adenine dinucleotide binding [GO:0050660]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine20a synthase activity [GO:0102266]; tRNA-dihydrouridine20b synthase activity [GO:0102267]		GO:0002943; GO:0017150; GO:0050660; GO:0102266; GO:0102267
GN018951	GN018951.1	Q9BYP7	69.0	368	2098	1800	5.16e-143	494	WNK3_HUMAN	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3)	Homo sapiens (Human)	cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; maintenance of blood-brain barrier [GO:0035633]; membraneless organelle assembly [GO:0140694]; monoatomic ion homeostasis [GO:0050801]; negative regulation of apoptotic process [GO:0043066]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; osmosensory signaling pathway [GO:0007231]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of calcium ion import [GO:0090279]; regulation of monoatomic cation transmembrane transport [GO:1904062]; renal sodium ion absorption [GO:0070294]	ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transmembrane transporter binding [GO:0044325]; transporter activator activity [GO:0141109]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0005912; GO:0005923; GO:0006468; GO:0006884; GO:0006974; GO:0007231; GO:0010765; GO:0010800; GO:0035556; GO:0035633; GO:0043066; GO:0044325; GO:0050801; GO:0051928; GO:0070294; GO:0071474; GO:0072659; GO:0090188; GO:0090263; GO:0090279; GO:0106310; GO:0140693; GO:0140694; GO:0141109; GO:1903077; GO:1903078; GO:1904062; GO:2000651
GN018953	GN018953.1	Q6DIH3	74.9	882	886	884	0.0	1272	MCM2_XENTR	DNA replication licensing factor mcm2 (EC 3.6.4.12) (Minichromosome maintenance protein 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cell cycle DNA replication [GO:0044786]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; chromosome [GO:0005694]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; nucleus [GO:0005634]	GO:0000727; GO:0000785; GO:0003678; GO:0003697; GO:0005524; GO:0005634; GO:0005694; GO:0016887; GO:0030174; GO:0042555; GO:0044786; GO:0071162; GO:1902975
GN018954	GN018954.1	O34507	26.8	157	1111	648	8.35e-12	73.2	PRKC_BACSU	Serine/threonine-protein kinase PrkC (Ser/Thr-protein kinase PrkC) (EC 2.7.11.1)	Bacillus subtilis (strain 168)	cellular response to peptidoglycan [GO:0071224]; signal transduction [GO:0007165]; spore germination [GO:0009847]	ATP binding [GO:0005524]; peptidoglycan binding [GO:0042834]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cell septum [GO:0030428]; plasma membrane [GO:0005886]; spore inner membrane [GO:0140549]	GO:0004674; GO:0005524; GO:0005886; GO:0007165; GO:0009847; GO:0030428; GO:0042834; GO:0071224; GO:0106310; GO:0140549
GN018955	GN018955.1	B2IZD3	27.9	179	1084	693	5.20e-10	67.4	BDLP_NOSP7	Bacterial dynamin-like protein (BDLP) (EC 3.6.5.5)	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	mitochondrial fusion [GO:0008053]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]	plasma membrane [GO:0005886]	GO:0003924; GO:0005525; GO:0005886; GO:0008053; GO:0008289; GO:0042802
GN018956	GN018956.1	B2IZD3	20.5	380	1082	693	1.06e-13	79.3	BDLP_NOSP7	Bacterial dynamin-like protein (BDLP) (EC 3.6.5.5)	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	mitochondrial fusion [GO:0008053]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]	plasma membrane [GO:0005886]	GO:0003924; GO:0005525; GO:0005886; GO:0008053; GO:0008289; GO:0042802
GN018957	GN018957.1	Q9HC24	53.8	225	239	238	9.84e-73	224	LFG4_HUMAN	Protein lifeguard 4 (Golgi anti-apoptotic protein) (Protein S1R) (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein)	Homo sapiens (Human)	endoplasmic reticulum unfolded protein response [GO:0030968]; locomotory behavior [GO:0007626]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of calcium-mediated signaling [GO:0050848]	calcium channel activity [GO:0005262]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]	GO:0000139; GO:0005262; GO:0005789; GO:0005794; GO:0005795; GO:0007626; GO:0030968; GO:0043066; GO:0043524; GO:0050848
GN018958	GN018958.1	Q9Y2M2	33.2	310	402	375	2.00e-40	150	SSUH2_HUMAN	Protein SSUH2 homolog (Protein ssu-2 homolog)	Homo sapiens (Human)	odontogenesis [GO:0042476]	heat shock protein binding [GO:0031072]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0031072; GO:0042476
GN018959	GN018959.1	Q460N3	26.1	591	612	678	4.02e-36	147	PAR15_HUMAN	Protein mono-ADP-ribosyltransferase PARP15 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) (Poly [ADP-ribose] polymerase 15) (PARP-15)	Homo sapiens (Human)	negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein poly-ADP-ribosylation [GO:0070212]	NAD+ binding [GO:0070403]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000122; GO:0003714; GO:0003950; GO:0005634; GO:0005737; GO:0010629; GO:0070212; GO:0070403; GO:0140806; GO:0140807; GO:1990404
GN018960	GN018960.1	Q9Y2M2	33.2	310	402	375	2.00e-40	150	SSUH2_HUMAN	Protein SSUH2 homolog (Protein ssu-2 homolog)	Homo sapiens (Human)	odontogenesis [GO:0042476]	heat shock protein binding [GO:0031072]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0031072; GO:0042476
GN018961	GN018961.1	Q9HC24	53.8	225	239	238	9.84e-73	224	LFG4_HUMAN	Protein lifeguard 4 (Golgi anti-apoptotic protein) (Protein S1R) (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein)	Homo sapiens (Human)	endoplasmic reticulum unfolded protein response [GO:0030968]; locomotory behavior [GO:0007626]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of calcium-mediated signaling [GO:0050848]	calcium channel activity [GO:0005262]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]	GO:0000139; GO:0005262; GO:0005789; GO:0005794; GO:0005795; GO:0007626; GO:0030968; GO:0043066; GO:0043524; GO:0050848
GN018962	GN018962.1	P55918	46.2	182	178	255	1.54e-48	160	MFAP4_BOVIN	Microfibril-associated glycoprotein 4 (36 kDa microfibril-associated glycoprotein) (36 kDa MAP)	Bos taurus (Bovine)	elastic fiber assembly [GO:0048251]		elastic fiber [GO:0071953]; extracellular matrix [GO:0031012]	GO:0031012; GO:0048251; GO:0071953
GN018966	GN018966.1	O01666	48.8	166	162	297	4.66e-43	147	ATPG_DROME	ATP synthase subunit gamma, mitochondrial (F-ATPase gamma subunit)	Drosophila melanogaster (Fruit fly)	proton motive force-driven ATP synthesis [GO:0015986]	proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; proton-transporting ATP synthase complex [GO:0045259]	GO:0005739; GO:0005743; GO:0015986; GO:0045259; GO:0046933
GN018967	GN018967.1	Q5RBS9	62.3	106	191	297	4.61e-36	130	ATPG_PONAB	ATP synthase F(1) complex subunit gamma, mitochondrial (ATP synthase F1 subunit gamma) (F-ATPase gamma subunit)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)		proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]	mitochondrial inner membrane [GO:0005743]; proton-transporting ATP synthase complex [GO:0045259]	GO:0005743; GO:0045259; GO:0046933
GN018968	GN018968.1	Q08C76	40.3	355	370	361	3.82e-47	167	SSUH2_DANRE	Protein SSUH2 homolog (Protein ssu-2 homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	odontogenesis [GO:0042476]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0042476
GN018969	GN018969.1	Q28IV3	41.1	248	453	657	1.62e-45	171	RPAP3_XENTR	RNA polymerase II-associated protein 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)				
GN018970	GN018970.1	B3EWZ6	47.6	82	81	7311	2.88e-15	72.0	MLRP2_ACRMI	MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN018971	GN018971.1	Q63416	39.3	257	325	887	1.79e-48	177	ITIH3_RAT	Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3)	Rattus norvegicus (Rat)	hyaluronan metabolic process [GO:0030212]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]	GO:0004867; GO:0005576; GO:0030212
GN018978	GN018978.1	P42700	28.5	526	533	538	6.97e-48	177	RO60_XENLA	RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2)	Xenopus laevis (African clawed frog)		misfolded RNA binding [GO:0034336]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005737; GO:0034336; GO:1990904
GN018979	GN018979.1	Q69Z37	23.0	418	1658	1561	9.28e-10	67.8	SAM9L_MOUSE	Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like)	Mus musculus (Mouse)	common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145]		cytoplasm [GO:0005737]; early endosome [GO:0005769]; mitochondrion [GO:0005739]	GO:0002244; GO:0005737; GO:0005739; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536
GN018981	GN018981.1	Q8BJD1	27.1	694	848	952	2.12e-56	213	ITIH5_MOUSE	Inter-alpha-trypsin inhibitor heavy chain H5 (ITI heavy chain H5) (ITI-HC5) (Inter-alpha-inhibitor heavy chain 5)	Mus musculus (Mouse)	hyaluronan metabolic process [GO:0030212]; uterus development [GO:0060065]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular matrix [GO:0031012]	GO:0004867; GO:0030212; GO:0031012; GO:0060065
GN018982	GN018982.1	Q5I0K7	52.8	161	176	165	6.55e-53	169	ALG13_RAT	UDP-N-acetylglucosamine transferase subunit ALG13 (EC 2.4.1.141) (Asparagine-linked glycosylation 13 homolog)	Rattus norvegicus (Rat)	dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487]	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [GO:0004577]	cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum membrane [GO:0005789]; UDP-N-acetylglucosamine transferase complex [GO:0043541]	GO:0004577; GO:0005789; GO:0006487; GO:0006488; GO:0043541; GO:0098554
GN018985	GN018985.1	Q8MPM1	50.9	342	346	366	2.50e-116	344	GELS2_LUMTE	Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2)	Lumbricus terrestris (Common earthworm)	actin polymerization or depolymerization [GO:0008154]	actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]	GO:0005737; GO:0008154; GO:0015629; GO:0051015
GN018987	GN018987.1	O62768	52.7	93	94	499	1.15e-23	96.3	TRXR1_BOVIN	Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1)	Bos taurus (Bovine)	cell redox homeostasis [GO:0045454]; response to oxidative stress [GO:0006979]; selenium compound metabolic process [GO:0001887]	FAD binding [GO:0071949]; identical protein binding [GO:0042802]; methylseleninic acid reductase activity [GO:0098626]; methylselenol reductase activity [GO:0098625]; NADPH peroxidase activity [GO:0050137]; thioredoxin-disulfide reductase (NADPH) activity [GO:0004791]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; thioredoxin-disulfide reductase complex [GO:1902515]	GO:0001887; GO:0004791; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0006979; GO:0042802; GO:0045454; GO:0050137; GO:0071949; GO:0098625; GO:0098626; GO:1902515
GN018988	GN018988.1	Q6DBU5	72.9	144	144	360	4.65e-63	199	GMPPB_DANRE	Mannose-1-phosphate guanylyltransferase catalytic subunit beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta)	Danio rerio (Zebrafish) (Brachydanio rerio)	GDP-mannose biosynthetic process [GO:0009298]; glycoprotein biosynthetic process [GO:0009101]; muscle cell development [GO:0055001]; neuron development [GO:0048666]; skeletal muscle tissue development [GO:0007519]	GTP binding [GO:0005525]; mannose-1-phosphate guanylyltransferase (GTP) activity [GO:0004475]		GO:0004475; GO:0005525; GO:0007519; GO:0009101; GO:0009298; GO:0048666; GO:0055001
GN018989	GN018989.1	P80147	52.5	179	185	500	3.87e-63	205	GABT_PIG	4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)	Sus scrofa (Pig)	GABA catabolic process [GO:0009450]; GABA shunt [GO:0006540]; nervous system process [GO:0050877]	(S)-3-amino-2-methylpropionate:2-oxoglutarate transaminase activity [GO:0047298]; 4-aminobutyrate:2-oxoglutarate transaminase activity [GO:0034386]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; succinate-semialdehyde dehydrogenase binding [GO:0032145]	4-aminobutyrate transaminase complex [GO:0032144]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759; GO:0005829; GO:0006540; GO:0009450; GO:0030170; GO:0032144; GO:0032145; GO:0034386; GO:0042803; GO:0047298; GO:0050877
GN018991	GN018991.1	A4IGK4	43.3	127	285	838	2.28e-17	85.5	RBM5_XENTR	RNA-binding protein 5 (RNA-binding motif protein 5)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; spliceosomal complex assembly [GO:0000245]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nucleus [GO:0005634]	GO:0000245; GO:0000381; GO:0003723; GO:0003729; GO:0005634; GO:0043065
GN018995	GN018995.1	Q5M8Z0	32.1	340	400	403	2.95e-46	166	BHMT1_XENTR	Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	amino-acid betaine catabolic process [GO:0006579]	betaine-homocysteine S-methyltransferase activity [GO:0047150]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0006579; GO:0008270; GO:0047150
GN018996	GN018996.1	Q5RF32	33.9	330	344	363	5.52e-47	166	BHMT2_PONAB	S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	L-methionine salvage [GO:0071267]	S-methylmethionine-homocysteine S-methyltransferase activity [GO:0061627]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]	GO:0005829; GO:0008270; GO:0061627; GO:0071267
GN018997	GN018997.1	Q8VYN9	33.7	163	150	242	2.18e-10	60.1	PHO32_ARATH	Universal stress protein PHOS32 (Phosphorylated protein of 32 kDa) (AtPHOS32)	Arabidopsis thaliana (Mouse-ear cress)	response to molecule of fungal origin [GO:0002238]		chloroplast [GO:0009507]; nucleus [GO:0005634]; plastid [GO:0009536]	GO:0002238; GO:0005634; GO:0009507; GO:0009536
GN019000	GN019000.1	P20678	37.1	463	487	491	2.22e-97	305	CP2H2_CHICK	Cytochrome P450 2H2 (EC 1.14.14.1) (CYPIIH2) (Cytochrome P450 PCHP7)	Gallus gallus (Chicken)	epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805]	arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005737; GO:0005789; GO:0006805; GO:0008392; GO:0016712; GO:0019373; GO:0020037
GN019001	GN019001.1	Q58588	20.8	385	667	301	1.19e-11	69.7	Y1187_METJA	Uncharacterized protein MJ1187 (EC 3.2.2.-)	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)				
GN019002	GN019002.1	Q9BV10	51.2	404	407	488	1.58e-142	417	ALG12_HUMAN	Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12 homolog) (hALG12) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Mannosyltransferase ALG12 homolog) (Membrane protein SB87)	Homo sapiens (Human)	dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein folding [GO:0006457]; protein N-linked glycosylation [GO:0006487]	alpha-1,6-mannosyltransferase activity [GO:0000009]; dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity [GO:0052917]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]	GO:0000009; GO:0000030; GO:0005783; GO:0005789; GO:0006457; GO:0006487; GO:0006488; GO:0016020; GO:0052917; GO:0098553
GN019003	GN019003.1	Q58PK6	26.3	361	649	1236	1.13e-23	110	ILE2_BOMVA	Peptidylaminoacyl-L/D-isomerase polyprotein (EC 5.1.1.21) (Frog skin isomerase)	Bombina variegata (Yellow-bellied toad)				
GN019004	GN019004.1	P30926	28.0	311	457	498	7.85e-35	139	ACHB4_HUMAN	Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (Human)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; positive regulation of transmission of nerve impulse [GO:0051971]; regulation of appetite [GO:0032098]; regulation of neurotransmitter secretion [GO:0046928]; response to acetylcholine [GO:1905144]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]	acetylcholine-gated channel complex [GO:0005892]; cell junction [GO:0030054]; cholinergic synapse [GO:0098981]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; specific granule membrane [GO:0035579]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; tertiary granule membrane [GO:0070821]	GO:0005886; GO:0005892; GO:0006811; GO:0006816; GO:0007165; GO:0007271; GO:0015276; GO:0015464; GO:0016020; GO:0022848; GO:0030054; GO:0032098; GO:0034220; GO:0035579; GO:0042734; GO:0043005; GO:0045202; GO:0046928; GO:0051899; GO:0051971; GO:0060084; GO:0070821; GO:0095500; GO:0097060; GO:0098981; GO:0099634; GO:1905144
GN019005	GN019005.1	Q9VHS7	59.5	294	380	392	1.94e-128	377	COQ2_DROME	4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (Coenzyme Q biosynthesis protein 2) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase)	Drosophila melanogaster (Fruit fly)	defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744]	4-hydroxybenzoate polyprenyltransferase activity [GO:0008412]	mitochondrial inner membrane [GO:0005743]	GO:0005743; GO:0006744; GO:0008299; GO:0008412; GO:0050829; GO:0050830; GO:0050832
GN019008	GN019008.1	P15056	48.8	727	723	766	2.12e-201	590	BRAF_HUMAN	Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)	Homo sapiens (Human)	animal organ morphogenesis [GO:0009887]; cellular response to calcium ion [GO:0071277]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of protein localization to membrane [GO:0090150]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; positive regulation of D-glucose transmembrane transport [GO:0010828]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; MAP kinase kinase activity [GO:0004708]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; scaffold protein binding [GO:0097110]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	GO:0000165; GO:0004672; GO:0004674; GO:0004708; GO:0004709; GO:0005509; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006468; GO:0007173; GO:0009887; GO:0010628; GO:0010828; GO:0033138; GO:0042802; GO:0043005; GO:0043066; GO:0044297; GO:0070374; GO:0071277; GO:0090150; GO:0097110; GO:0098794; GO:0098978; GO:0099170; GO:0106310
GN019009	GN019009.1	P97879	39.8	1047	1040	1112	1.15e-216	652	GRIP1_RAT	Glutamate receptor-interacting protein 1 (GRIP-1) (AMPA receptor-interacting protein GRIP1)	Rattus norvegicus (Rat)	cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to glycine [GO:1905430]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cerebral cortex development [GO:0021987]; dendrite arborization [GO:0140059]; intracellular protein localization [GO:0008104]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; nervous system development [GO:0007399]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of mini excitatory postsynaptic potential [GO:0061885]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of protein localization to plasma membrane [GO:1903078]; receptor internalization [GO:0031623]; regulation of AMPA receptor activity [GO:2000311]; regulation of kainate selective glutamate receptor signaling pathway [GO:0106426]; regulation of synaptic scaling [GO:0150092]; response to phorbol 13-acetate 12-myristate [GO:1904627]	GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; PDZ domain binding [GO:0030165]; signaling receptor binding [GO:0005102]; signaling receptor complex adaptor activity [GO:0030159]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; dendritic spine head [GO:0044327]; dendritic spine neck [GO:0044326]; endoplasmic reticulum membrane [GO:0005789]; excitatory synapse [GO:0060076]; exocyst [GO:0000145]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; membrane raft [GO:0045121]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; proximal dendrite [GO:1990635]; recycling endosome [GO:0055037]; spine synapse [GO:0106033]; synaptic cleft [GO:0043083]; synaptic membrane [GO:0097060]; terminal bouton [GO:0043195]	GO:0000145; GO:0005102; GO:0005737; GO:0005789; GO:0005874; GO:0005886; GO:0007399; GO:0008104; GO:0014069; GO:0021987; GO:0030159; GO:0030165; GO:0030425; GO:0031410; GO:0031623; GO:0035255; GO:0042734; GO:0042802; GO:0043005; GO:0043025; GO:0043083; GO:0043195; GO:0043197; GO:0043198; GO:0043204; GO:0044326; GO:0044327; GO:0045121; GO:0045211; GO:0048471; GO:0048786; GO:0050775; GO:0051020; GO:0055037; GO:0060076; GO:0060291; GO:0060292; GO:0061885; GO:0097060; GO:0098793; GO:0098794; GO:0098887; GO:0098978; GO:0098982; GO:0106033; GO:0106426; GO:0140059; GO:0150012; GO:0150092; GO:1903078; GO:1904627; GO:1904628; GO:1905430; GO:1990416; GO:1990635; GO:2000311
GN019010	GN019010.1	Q9N294	33.3	150	214	301	7.50e-24	99.4	B3GT5_PANPA	Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)	Pan paniscus (Pygmy chimpanzee) (Bonobo)	protein O-linked glycosylation [GO:0006493]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005783; GO:0006493; GO:0008499
GN019011	GN019011.1	Q9D5U8	27.0	226	880	673	2.76e-15	84.0	CNBD2_MOUSE	Cyclic nucleotide-binding domain-containing protein 2 (Cyclic nucleotide receptor involved in sperm function)	Mus musculus (Mouse)	spermatogenesis [GO:0007283]	cAMP binding [GO:0030552]	cytosol [GO:0005829]; sperm midpiece [GO:0097225]	GO:0005829; GO:0007283; GO:0030552; GO:0097225
GN019012	GN019012.1	P30531	56.9	576	640	599	2.81e-244	690	SC6A1_HUMAN	Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)	Homo sapiens (Human)	amino acid transport [GO:0006865]; associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid reuptake [GO:0051936]; inorganic anion import across plasma membrane [GO:0098658]; memory [GO:0007613]; neurotransmitter transport [GO:0006836]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]; transport across blood-brain barrier [GO:0150104]	gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; sodium:chloride symporter activity [GO:0015378]	axon [GO:0030424]; cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0005332; GO:0005886; GO:0006836; GO:0006865; GO:0007268; GO:0007613; GO:0008306; GO:0009986; GO:0015185; GO:0015378; GO:0016020; GO:0030424; GO:0035725; GO:0043025; GO:0050808; GO:0051936; GO:0051939; GO:0098658; GO:0098719; GO:0098793; GO:0098982; GO:0150104; GO:1902476
GN019013	GN019013.1	F8WLE0	39.8	852	986	1034	1.47e-170	528	KIF28_RAT	Kinesin-like protein KIF28 (Kinesin family member 28) (Kinesin-like protein 6)	Rattus norvegicus (Rat)	mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384]; vesicle transport along microtubule [GO:0047496]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	kinesin complex [GO:0005871]; mitochondrial membrane [GO:0031966]	GO:0003777; GO:0005524; GO:0005871; GO:0007005; GO:0008017; GO:0031966; GO:0047496; GO:0072384
GN019014	GN019014.1	Q99MV5	52.6	57	64	1187	1.90e-15	71.6	M10L1_MOUSE	RNA helicase Mov10l1 (EC 5.6.2.5) (Cardiac helicase activated by MEF2 protein) (Cardiac-specific RNA helicase) (Moloney leukemia virus 10-like protein 1 homolog) (MOV10-like protein 1 homolog) (RNA 5'-3' helicase Mov10l1)	Mus musculus (Mouse)	male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; negative regulation of cell cycle [GO:0045786]; piRNA processing [GO:0034587]; spermatogenesis [GO:0007283]; transposable element silencing by piRNA-mediated DNA methylation [GO:0141196]	5'-3' RNA helicase activity [GO:0032574]; piRNA binding [GO:0034584]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; P granule [GO:0043186]; pi-body [GO:0071546]	GO:0003724; GO:0005737; GO:0005829; GO:0007140; GO:0007141; GO:0007283; GO:0032574; GO:0034584; GO:0034587; GO:0043186; GO:0045786; GO:0071546; GO:0141196
GN019015	GN019015.1	Q704V6	31.2	138	151	793	1.75e-16	78.6	TLR6_BOVIN	Toll-like receptor 6 (CD antigen CD286)	Bos taurus (Bovine)	cellular response to diacyl bacterial lipopeptide [GO:0071726]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; toll-like receptor signaling pathway [GO:0002224]	identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	GO:0002224; GO:0004888; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0030670; GO:0032731; GO:0035355; GO:0035663; GO:0038023; GO:0042802; GO:0045121; GO:0071723; GO:0071726; GO:1900227
GN019016	GN019016.1	Q5ZKW0	48.9	403	396	424	6.23e-134	393	MTU1_CHICK	Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14)	Gallus gallus (Chicken)	mitochondrial tRNA wobble position uridine thiolation [GO:1990799]	tRNA-5-taurinomethyluridine 2-sulfurtransferase activity [GO:0061708]	mitochondrion [GO:0005739]	GO:0005739; GO:0061708; GO:1990799
GN019019	GN019019.1	Q9NRM2	50.9	403	436	450	3.21e-143	419	ZN277_HUMAN	Zinc finger protein 277 (Nuclear receptor-interacting factor 4)	Homo sapiens (Human)		RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0005634
GN019020	GN019020.1	O16796	22.8	668	759	848	1.94e-28	125	NPL11_CAEEL	Neprilysin-11 (EC 3.4.24.-)	Caenorhabditis elegans	protein processing [GO:0016485]	metalloendopeptidase activity [GO:0004222]	plasma membrane [GO:0005886]	GO:0004222; GO:0005886; GO:0016485
GN019021	GN019021.1	Q07E01	27.7	1421	1366	1382	2.45e-129	437	MET_ORNAN	Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)	Ornithorhynchus anatinus (Duckbill platypus)	cell development [GO:0048468]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; liver development [GO:0001889]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; regulation of gene expression [GO:0010468]; semaphorin-plexin signaling pathway [GO:0071526]	ATP binding [GO:0005524]; hepatocyte growth factor receptor activity [GO:0005008]; semaphorin receptor activity [GO:0017154]	basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001889; GO:0005008; GO:0005524; GO:0005886; GO:0007169; GO:0009925; GO:0010468; GO:0017154; GO:0030182; GO:0031016; GO:0043235; GO:0048468; GO:0050918; GO:0071526; GO:2001028
GN019022	GN019022.1	O95243	32.2	661	822	580	1.00e-71	249	MBD4_HUMAN	Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase)	Homo sapiens (Human)	depyrimidination [GO:0045008]; DNA repair [GO:0006281]; response to estradiol [GO:0032355]	DNA binding [GO:0003677]; DNA endonuclease activity [GO:0004520]; DNA N-glycosylase activity [GO:0019104]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; satellite DNA binding [GO:0003696]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003677; GO:0003696; GO:0004520; GO:0005634; GO:0005654; GO:0006281; GO:0008263; GO:0016607; GO:0019104; GO:0032355; GO:0045008
GN019023	GN019023.1	Q6DDT4	51.1	532	522	517	6.58e-164	478	APEX2_XENLA	DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2)	Xenopus laevis (African clawed frog)	base-excision repair [GO:0006284]	DNA binding [GO:0003677]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; double-stranded DNA 3'-5' DNA exonuclease activity [GO:0008311]; phosphoric diester hydrolase activity [GO:0008081]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0003677; GO:0003906; GO:0005634; GO:0005694; GO:0005739; GO:0006284; GO:0008081; GO:0008270; GO:0008311
GN019024	GN019024.1	A1A5B6	33.2	756	746	742	2.20e-112	360	TBC25_MOUSE	TBC1 domain family member 25	Mus musculus (Mouse)	regulation of autophagosome maturation [GO:1901096]	GTPase activator activity [GO:0005096]	autophagosome [GO:0005776]	GO:0005096; GO:0005776; GO:1901096
GN019025	GN019025.1	Q96QE2	53.1	565	608	648	3.91e-200	578	MYCT_HUMAN	Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13)	Homo sapiens (Human)	myo-inositol transport [GO:0015798]; positive regulation of amyloid-beta formation [GO:1902004]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	ATPase binding [GO:0051117]; myo-inositol transmembrane transporter activity [GO:0005365]; myo-inositol:proton symporter activity [GO:0005366]; protease binding [GO:0002020]	apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; cell body [GO:0044297]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]	GO:0002020; GO:0005365; GO:0005366; GO:0005737; GO:0005794; GO:0005886; GO:0015798; GO:0016020; GO:0016324; GO:0030426; GO:0031090; GO:0042995; GO:0044297; GO:0051117; GO:0055085; GO:0071944; GO:0097450; GO:0150104; GO:1902004
GN019026	GN019026.1	Q5XIA9	34.3	172	345	354	5.19e-19	90.1	KLD8B_RAT	Kelch domain-containing protein 8B	Rattus norvegicus (Rat)	mitotic cytokinetic process [GO:1902410]; mitotic nuclear division [GO:0140014]; nuclear chromosome segregation [GO:0098813]		cellularization cleavage furrow [GO:0110070]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; midbody [GO:0030496]	GO:0005737; GO:0005829; GO:0030496; GO:0045171; GO:0098813; GO:0110070; GO:0140014; GO:1902410
GN019027	GN019027.1	C3YWU0	55.5	447	455	449	9.27e-197	556	FUCO_BRAFL	Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase)	Branchiostoma floridae (Florida lancelet) (Amphioxus)	fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]	alpha-L-fucosidase activity [GO:0004560]	extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0004560; GO:0005576; GO:0005764; GO:0006004; GO:0016139
GN019028	GN019028.1	Q9UBJ2	66.1	442	447	740	1.46e-196	566	ABCD2_HUMAN	ATP-binding cassette sub-family D member 2 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy-like 1) (Adrenoleukodystrophy-related protein) (hALDR)	Homo sapiens (Human)	fatty acid beta-oxidation [GO:0006635]; fatty acid biosynthetic process [GO:0006633]; long-chain fatty acid import into peroxisome [GO:0015910]; myelin maintenance [GO:0043217]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neuron projection maintenance [GO:1990535]; peroxisome organization [GO:0007031]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of unsaturated fatty acid biosynthetic process [GO:2001280]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038]	ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; fatty acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; very long-chain fatty acyl-CoA hydrolase activity [GO:0052817]	cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0000038; GO:0005324; GO:0005524; GO:0005777; GO:0005778; GO:0005829; GO:0006633; GO:0006635; GO:0007031; GO:0015910; GO:0016887; GO:0032000; GO:0042626; GO:0042760; GO:0042803; GO:0043217; GO:0046982; GO:0047617; GO:0052817; GO:0140359; GO:1900016; GO:1903427; GO:1990535; GO:2001280
GN019029	GN019029.1	A2RV80	31.6	503	580	578	1.25e-56	203	GRAM4_XENLA	GRAM domain-containing protein 4	Xenopus laevis (African clawed frog)	apoptotic process [GO:0006915]; negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]		endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]	GO:0005789; GO:0006915; GO:0031966; GO:0034164
GN019037	GN019037.1	Q9H2M3	34.3	332	349	363	2.49e-55	187	BHMT2_HUMAN	S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2)	Homo sapiens (Human)	L-methionine salvage [GO:0071267]; S-adenosylmethionine metabolic process [GO:0046500]; S-methylmethionine metabolic process [GO:0033477]	S-methylmethionine-homocysteine S-methyltransferase activity [GO:0061627]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0005829; GO:0008270; GO:0033477; GO:0046500; GO:0061627; GO:0070062; GO:0071267
GN019041	GN019041.1	Q5D013	44.0	182	197	233	6.52e-48	159	EFMT2_DANRE	EEF1A lysine methyltransferase 2 (EC 2.1.1.-) (Methyltransferase-like protein 10) (Protein-lysine N-methyltransferase mettl10)	Danio rerio (Zebrafish) (Brachydanio rerio)		methyltransferase activity [GO:0008168]; protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0008168; GO:0016279
GN019042	GN019042.1	Q3T0F5	87.4	207	205	207	2.78e-127	360	RAB7A_BOVIN	Ras-related protein Rab-7a (EC 3.6.5.2)	Bos taurus (Bovine)	early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; endosome to plasma membrane protein transport [GO:0099638]; lipophagy [GO:0061724]; phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]	GO:0000421; GO:0003924; GO:0003925; GO:0005525; GO:0005739; GO:0005764; GO:0005765; GO:0005770; GO:0005811; GO:0005829; GO:0008333; GO:0010008; GO:0030670; GO:0031410; GO:0031902; GO:0031966; GO:0033162; GO:0045022; GO:0045335; GO:0061724; GO:0090383; GO:0090385; GO:0099638
GN019043	GN019043.1	C4A0D9	74.3	269	278	694	3.15e-134	398	BAP1_BRAFL	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1)	Branchiostoma floridae (Florida lancelet) (Amphioxus)	heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromatin binding [GO:0003682]; cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; PR-DUB complex [GO:0035517]	GO:0001558; GO:0003682; GO:0004843; GO:0005634; GO:0005737; GO:0006511; GO:0016579; GO:0031507; GO:0035517; GO:0045892; GO:0051726; GO:0071108
GN019044	GN019044.1	P53545	41.1	90	229	245	2.62e-11	64.7	GSC_CHICK	Homeobox protein goosecoid	Gallus gallus (Chicken)	animal organ development [GO:0048513]; regulation of transcription by RNA polymerase II [GO:0006357]; tissue development [GO:0009888]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0009888; GO:0048513
GN019045	GN019045.1	A0QZA1	29.5	139	142	294	1.22e-09	58.2	Y3950_MYCS2	Universal stress protein MSMEG_3950/MSMEI_3859 (USP MSMEG_3950)	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)				
GN019046	GN019046.1	Q9D826	49.5	384	382	390	2.94e-125	369	SOX_MOUSE	Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase)	Mus musculus (Mouse)	amino acid catabolic process [GO:0009063]; L-lysine catabolic process [GO:0019477]	flavin adenine dinucleotide binding [GO:0050660]; L-pipecolate oxidase activity [GO:0050031]; sarcosine oxidase activity [GO:0008115]	peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0005777; GO:0005782; GO:0008115; GO:0009063; GO:0019477; GO:0050031; GO:0050660
GN019047	GN019047.1	Q9ES30	28.4	134	184	246	9.58e-10	59.3	C1QT3_MOUSE	Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)	Mus musculus (Mouse)	fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; intracellular triglyceride homeostasis [GO:0035356]; maintenance of synapse structure [GO:0099558]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine production [GO:0001819]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	extracellular region [GO:0005576]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0001819; GO:0005576; GO:0010629; GO:0032715; GO:0032991; GO:0035356; GO:0042593; GO:0042802; GO:0043083; GO:0045202; GO:0045444; GO:0045721; GO:0050728; GO:0051897; GO:0070165; GO:0070374; GO:0071638; GO:0099550; GO:0099558; GO:1901223
GN019050	GN019050.1	Q5ZKD7	45.8	863	1102	967	2.73e-237	703	MOV10_CHICK	RNA helicase MOV-10 (EC 5.6.2.5) (RNA 5'-3' helicase MOV-10)	Gallus gallus (Chicken)	3'-UTR-mediated mRNA destabilization [GO:0061158]; miRNA-mediated gene silencing by mRNA destabilization [GO:0035279]; miRNA-mediated post-transcriptional gene silencing [GO:0035195]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of neuron projection arborization [GO:0150011]; transposable element silencing [GO:0010526]	5'-3' RNA helicase activity [GO:0032574]; ATP hydrolysis activity [GO:0016887]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P granule [GO:0043186]; P-body [GO:0000932]	GO:0000932; GO:0003723; GO:0005634; GO:0005737; GO:0005829; GO:0010494; GO:0010526; GO:0016887; GO:0032574; GO:0035195; GO:0035279; GO:0036464; GO:0043186; GO:0061014; GO:0061158; GO:0150011
GN019052	GN019052.1	P46023	44.3	334	2306	1115	4.54e-74	275	GR101_LYMST	G protein-coupled receptor GRL101	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; hormone-mediated signaling pathway [GO:0009755]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007189; GO:0008528; GO:0009755
GN019054	GN019054.1	G5EF51	29.1	223	1126	723	1.60e-16	88.6	KY_CAEEL	Lim and transglutaminase domain protein ltd-1 (Kyphoscoliosis inactive peptidase homolog ltd-1)	Caenorhabditis elegans	muscle structure development [GO:0061061]		cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; striated muscle dense body [GO:0055120]	GO:0005737; GO:0005856; GO:0005911; GO:0055120; GO:0061061
GN019055	GN019055.1	P39944	23.2	534	702	805	5.43e-16	85.9	UBP5_YEAST	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]	cellular bud neck [GO:0005935]; incipient cellular bud site [GO:0000131]	GO:0000131; GO:0004843; GO:0005935; GO:0016579
GN019056	GN019056.1	Q17902	39.2	166	588	574	7.29e-21	100	EGAL1_CAEEL	Egalitarian protein homolog	Caenorhabditis elegans	nuclear migration along microtubule [GO:0030473]; piRNA processing [GO:0034587]	3'-5' exonuclease activity [GO:0008408]; nucleic acid binding [GO:0003676]	microtubule associated complex [GO:0005875]; nuclear envelope [GO:0005635]; PET complex [GO:1990923]	GO:0003676; GO:0005635; GO:0005875; GO:0008408; GO:0030473; GO:0034587; GO:1990923
GN019057	GN019057.1	A0A2B4RNI3	31.1	196	1255	688	4.76e-10	67.8	CGLR2_STYPI	Cyclic GMP-AMP synthase-like receptor 2 (Sp-cGLR2) (EC 2.7.7.86)	Stylophora pistillata (Smooth cauliflower coral)		2',3'-cyclic GMP-AMP synthase activity [GO:0061501]		GO:0061501
GN019058	GN019058.1	Q95JR6	26.4	288	746	585	1.14e-17	90.9	CNBD2_MACFA	Cyclic nucleotide-binding domain-containing protein 2	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	spermatogenesis [GO:0007283]	cAMP binding [GO:0030552]	cytosol [GO:0005829]	GO:0005829; GO:0007283; GO:0030552
GN019059	GN019059.1	O75896	56.3	71	107	110	9.39e-21	82.8	TUSC2_HUMAN	Tumor suppressor candidate 2 (Fusion 1 protein) (Fus-1 protein) (PDGFA-associated protein 2)	Homo sapiens (Human)	inflammatory response [GO:0006954]; regulation of mitochondrial membrane potential [GO:0051881]		mitochondrion [GO:0005739]	GO:0005739; GO:0006954; GO:0051881
GN019060	GN019060.1	Q54KD0	21.9	343	419	1663	1.33e-11	70.5	Y7407_DICDI	TPR repeat-containing protein DDB_G0287407	Dictyostelium discoideum (Social amoeba)			Cul4-RING E3 ubiquitin ligase complex [GO:0080008]	GO:0080008
GN019061	GN019061.1	Q9UKG1	39.6	739	747	709	7.64e-151	459	DP13A_HUMAN	DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)	Homo sapiens (Human)	adiponectin-activated signaling pathway [GO:0033211]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; insulin receptor signaling pathway [GO:0008286]; maintenance of synapse structure [GO:0099558]; negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905450]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of D-glucose import across plasma membrane [GO:0046326]; positive regulation of macropinocytosis [GO:1905303]; positive regulation of melanin biosynthetic process [GO:0048023]; protein import into nucleus [GO:0006606]; regulation of D-glucose import across plasma membrane [GO:0046324]; regulation of fibroblast migration [GO:0010762]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of innate immune response [GO:0045088]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of toll-like receptor 4 signaling pathway [GO:0034143]; signal transduction [GO:0007165]; signaling [GO:0023052]; transforming growth factor beta receptor signaling pathway [GO:0007179]	beta-tubulin binding [GO:0048487]; identical protein binding [GO:0042802]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; protein kinase B binding [GO:0043422]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; intracellular vesicle [GO:0097708]; macropinosome [GO:0044354]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; vesicle membrane [GO:0012506]	GO:0001726; GO:0001786; GO:0005634; GO:0005737; GO:0005768; GO:0005769; GO:0005829; GO:0005886; GO:0006606; GO:0007165; GO:0007179; GO:0008286; GO:0010008; GO:0010762; GO:0012506; GO:0016020; GO:0023052; GO:0031410; GO:0031901; GO:0032009; GO:0033211; GO:0034143; GO:0035091; GO:0035729; GO:0042802; GO:0042803; GO:0043422; GO:0044354; GO:0044877; GO:0045088; GO:0046324; GO:0046326; GO:0048023; GO:0048487; GO:0070062; GO:0097708; GO:0098978; GO:0099558; GO:1900017; GO:1903076; GO:1905303; GO:1905450; GO:2000045
GN019066	GN019066.1	O43818	56.3	398	469	475	1.01e-98	307	U3IP2_HUMAN	U3 small nucleolar RNA-interacting protein 2 (RRP9 homolog) (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K)	Homo sapiens (Human)	maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; U3 snoRNA binding [GO:0034511]	box C/D methylation guide snoRNP complex [GO:0031428]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	GO:0003723; GO:0005654; GO:0005730; GO:0006364; GO:0030490; GO:0030515; GO:0031428; GO:0032040; GO:0034511; GO:0042274
GN019070	GN019070.1	Q9H4K1	42.2	374	379	382	2.66e-76	243	RIBC2_HUMAN	RIB43A-like with coiled-coils protein 2	Homo sapiens (Human)	flagellated sperm motility [GO:0030317]		axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0005634; GO:0005879; GO:0030317; GO:0036126; GO:0160111
GN019071	GN019071.1	O93308	58.7	1241	1251	1232	0.0	1248	SMC1A_XENLA	Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1A) (xSMC1)	Xenopus laevis (African clawed frog)	meiotic cell cycle [GO:0051321]; response to DNA damage checkpoint signaling [GO:0072423]; response to radiation [GO:0009314]; sister chromatid cohesion [GO:0007062]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]	kinetochore [GO:0000776]; meiotic cohesin complex [GO:0030893]; nucleus [GO:0005634]	GO:0000776; GO:0003677; GO:0003682; GO:0005524; GO:0005634; GO:0007062; GO:0009314; GO:0016887; GO:0030893; GO:0051321; GO:0072423
GN019072	GN019072.1	Q4R6T7	53.0	638	975	790	1.09e-218	644	IQUB_MACFA	IQ motif and ubiquitin-like domain-containing protein	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; mating [GO:0007618]		9+2 motile cilium [GO:0097729]; acrosomal vesicle [GO:0001669]; radial spoke [GO:0001534]; sperm flagellum [GO:0036126]	GO:0001534; GO:0001669; GO:0007618; GO:0030317; GO:0036126; GO:0060271; GO:0097729
GN019073	GN019073.1	O59028	42.6	108	114	360	2.30e-17	79.0	MDH_PYRHO	Malate dehydrogenase (EC 1.1.1.37)	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)		L-malate dehydrogenase (NAD+) activity [GO:0030060]	cytoplasm [GO:0005737]	GO:0005737; GO:0030060
GN019074	GN019074.1	Q9V4A7	28.1	1390	1632	2051	1.25e-127	445	PLXB_DROME	Plexin-B	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; motor neuron axon guidance [GO:0008045]; negative regulation of cell adhesion [GO:0007162]; olfactory bulb axon guidance [GO:0071678]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; sensory neuron axon guidance [GO:0097374]; synapse assembly [GO:0007416]	semaphorin receptor activity [GO:0017154]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	GO:0002116; GO:0005886; GO:0007162; GO:0007411; GO:0007416; GO:0008045; GO:0008360; GO:0017154; GO:0030334; GO:0030425; GO:0050772; GO:0070593; GO:0071526; GO:0071678; GO:0097374
GN019076	GN019076.1	Q5SWD9	50.9	790	787	803	3.58e-256	734	TSR1_MOUSE	Pre-rRNA-processing protein TSR1 homolog	Mus musculus (Mouse)	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	GTPase activity [GO:0003924]; RNA binding [GO:0003723]	90S preribosome [GO:0030686]; nucleolus [GO:0005730]	GO:0000462; GO:0000479; GO:0003723; GO:0003924; GO:0005730; GO:0030686
GN019077	GN019077.1	Q99714	40.9	264	288	261	1.02e-52	176	HCD2_HUMAN	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)	Homo sapiens (Human)	androgen metabolic process [GO:0008209]; bile acid biosynthetic process [GO:0006699]; brexanolone metabolic process [GO:0062173]; C21-steroid hormone metabolic process [GO:0008207]; estrogen metabolic process [GO:0008210]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; L-isoleucine catabolic process [GO:0006550]; lipid metabolic process [GO:0006629]; mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA 5'-end processing [GO:0097745]; mitochondrial tRNA methylation [GO:0070901]; mitochondrion organization [GO:0007005]; protein homotetramerization [GO:0051289]; tRNA 3'-end processing [GO:0042780]; tRNA 3'-terminal CCA addition [GO:0001680]	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0003857]; 17-beta-hydroxysteroid dehydrogenase (NAD+) activity [GO:0044594]; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity [GO:0047015]; androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity [GO:0047044]; cardiolipin dehydrogenase (NAD+) activity [GO:0160241]; chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity [GO:0106281]; cholate 7-alpha-dehydrogenase (NAD+) activity [GO:0008709]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity [GO:0106282]; long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0016509]; RNA binding [GO:0003723]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; tRNA binding [GO:0000049]; ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity [GO:0106283]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; endoribonuclease complex [GO:1902555]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; tRNA methyltransferase complex [GO:0043527]	GO:0000049; GO:0001680; GO:0003723; GO:0003857; GO:0004303; GO:0005737; GO:0005739; GO:0005759; GO:0005886; GO:0006550; GO:0006629; GO:0006631; GO:0006635; GO:0006699; GO:0007005; GO:0008207; GO:0008209; GO:0008210; GO:0008709; GO:0016509; GO:0030678; GO:0042645; GO:0042780; GO:0043527; GO:0044594; GO:0047015; GO:0047035; GO:0047044; GO:0051289; GO:0062173; GO:0070901; GO:0097745; GO:0106281; GO:0106282; GO:0106283; GO:0160241; GO:1902494; GO:1902555; GO:1990180
GN019082	GN019082.1	Q2KHX4	89.1	476	476	476	1.65e-314	856	S61A2_BOVIN	Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2)	Bos taurus (Bovine)	post-translational protein targeting to membrane, translocation [GO:0031204]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	ribosome binding [GO:0043022]; signal sequence binding [GO:0005048]; transmembrane protein transporter activity [GO:0008320]	endoplasmic reticulum membrane [GO:0005789]; Sec61 translocon complex [GO:0005784]	GO:0005048; GO:0005784; GO:0005789; GO:0006616; GO:0008320; GO:0031204; GO:0043022
GN019083	GN019083.1	Q9Y265	87.7	456	456	456	6.88e-283	774	RUVB1_HUMAN	RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)	Homo sapiens (Human)	box C/D snoRNP assembly [GO:0000492]; chromatin remodeling [GO:0006338]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; telomerase RNA localization to Cajal body [GO:0090671]; telomere maintenance [GO:0000723]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; DNA helicase activity [GO:0003678]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription coactivator activity [GO:0003713]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular exosome [GO:0070062]; Ino80 complex [GO:0031011]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812]	GO:0000492; GO:0000723; GO:0000786; GO:0000812; GO:0001094; GO:0003678; GO:0003713; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0006275; GO:0006338; GO:0006355; GO:0006357; GO:0007283; GO:0016020; GO:0016363; GO:0016607; GO:0016887; GO:0017025; GO:0031011; GO:0033044; GO:0035267; GO:0036064; GO:0042981; GO:0043531; GO:0045296; GO:0045893; GO:0045995; GO:0050821; GO:0051117; GO:0051726; GO:0060382; GO:0070062; GO:0071339; GO:0090263; GO:0090671; GO:0097255; GO:0101031; GO:0120293; GO:1904507; GO:1905168; GO:1990062; GO:1990904; GO:2000779
GN019084	GN019084.1	E9Q9F7	39.4	932	958	977	3.36e-181	553	CC146_MOUSE	Coiled-coil domain-containing protein 146	Mus musculus (Mouse)	cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; gene expression [GO:0010467]; manchette assembly [GO:1905198]; nucleus organization [GO:0006997]; single fertilization [GO:0007338]; sperm axoneme assembly [GO:0007288]; sperm flagellum assembly [GO:0120316]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	protein-containing complex binding [GO:0044877]	axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; midbody [GO:0030496]; sperm flagellum [GO:0036126]; sperm head-tail coupling apparatus [GO:0120212]	GO:0000902; GO:0005813; GO:0005814; GO:0005856; GO:0005930; GO:0006997; GO:0007283; GO:0007286; GO:0007288; GO:0007338; GO:0008283; GO:0010467; GO:0030317; GO:0030496; GO:0036064; GO:0036126; GO:0044782; GO:0044877; GO:0120212; GO:0120316; GO:1905198
GN019085	GN019085.1	Q0VC03	32.4	389	397	450	1.33e-65	218	MFSD5_BOVIN	Solute carrier family 61 member 1 (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) (Molybdate-anion transporter)	Bos taurus (Bovine)		molybdate ion transmembrane transporter activity [GO:0015098]	plasma membrane [GO:0005886]	GO:0005886; GO:0015098
GN019088	GN019088.1	Q7ZT75	50.5	212	402	315	2.84e-70	226	FCN1A_XENLA	Ficolin-1-A	Xenopus laevis (African clawed frog)	complement activation, lectin pathway [GO:0001867]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; pattern recognition receptor activity [GO:0038187]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; symbiont cell surface [GO:0106139]	GO:0001867; GO:0003823; GO:0005102; GO:0009986; GO:0031012; GO:0033691; GO:0038187; GO:0097367; GO:0106139
GN019089	GN019089.1	H3BNL1	42.5	113	291	204	1.37e-22	95.9	CMIP7_HUMAN	Ciliary microtubule inner protein 7	Homo sapiens (Human)			cilium [GO:0005929]	GO:0005929
GN019090	GN019090.1	Q90X38	41.4	449	451	506	7.23e-77	251	GPKOW_DANRE	G-patch domain and KOW motifs-containing protein (Protein T54-like)	Danio rerio (Zebrafish) (Brachydanio rerio)	mRNA splicing, via spliceosome [GO:0000398]	RNA binding [GO:0003723]	nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	GO:0000398; GO:0003723; GO:0005634; GO:0005681
GN019091	GN019091.1	P00639	46.4	261	282	282	7.17e-71	223	DNAS1_BOVIN	Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I)	Bos taurus (Bovine)	DNA catabolic process [GO:0006308]; neutrophil activation involved in immune response [GO:0002283]; regulation of acute inflammatory response [GO:0002673]; regulation of neutrophil mediated cytotoxicity [GO:0070948]	deoxyribonuclease I activity [GO:0004530]; DNA binding [GO:0003677]	extracellular region [GO:0005576]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; zymogen granule [GO:0042588]	GO:0002283; GO:0002673; GO:0003677; GO:0004530; GO:0005576; GO:0005634; GO:0005635; GO:0006308; GO:0042588; GO:0070948
GN019092	GN019092.1	Q8K0U4	30.3	501	474	675	3.04e-66	228	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN019094	GN019094.1	A2VD82	34.2	418	423	469	2.84e-71	234	TTC38_XENLA	Tetratricopeptide repeat protein 38 (TPR repeat protein 38)	Xenopus laevis (African clawed frog)				
GN019096	GN019096.1	Q9D906	56.2	692	694	698	5.11e-281	789	ATG7_MOUSE	Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (mAGP7) (Ubiquitin-activating enzyme E1-like protein)	Mus musculus (Mouse)	adult walking behavior [GO:0007628]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cardiac muscle cell development [GO:0055013]; cell population proliferation [GO:0008283]; cellular response to hyperoxia [GO:0071455]; cellular response to nitrogen starvation [GO:0006995]; cellular response to reactive oxygen species [GO:0034614]; cellular response to sodium arsenite [GO:1903936]; cellular response to starvation [GO:0009267]; cellular response to stress [GO:0033554]; central nervous system neuron axonogenesis [GO:0021955]; cerebellar Purkinje cell layer development [GO:0021680]; cerebral cortex development [GO:0021987]; chaperone-mediated autophagy [GO:0061684]; defense response to virus [GO:0051607]; dendrite arborization [GO:0140059]; innate immune response [GO:0045087]; intracellular amino acid homeostasis [GO:0080144]; intracellular sphingolipid homeostasis [GO:0090156]; liver development [GO:0001889]; macroautophagy [GO:0016236]; membrane organization [GO:0061024]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of dendrite extension [GO:1903860]; negative regulation of mitochondrial DNA replication [GO:0090298]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of phagocytosis [GO:0050765]; negative regulation of programmed necrotic cell death [GO:0062099]; negative regulation of sphingolipid biosynthetic process [GO:0090155]; negative stranded viral RNA replication [GO:0039689]; nervous system process [GO:0050877]; neuron projection development [GO:0031175]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of autophagy [GO:0010508]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of mitophagy [GO:1901526]; positive regulation of mucus secretion [GO:0070257]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein modification process [GO:0031401]; post-embryonic development [GO:0009791]; protein catabolic process [GO:0030163]; protein lipidation [GO:0006497]; protein lipidation involved in autophagosome assembly [GO:0061739]; protein modification by small protein conjugation [GO:0032446]; pyramidal neuron development [GO:0021860]; regulation of cell development [GO:0060284]; regulation of circadian rhythm [GO:0042752]; regulation of hemopoiesis [GO:1903706]; regulation of protein ubiquitination [GO:0031396]; response to starvation [GO:0042594]; synaptic vesicle cycle [GO:0099504]	Atg12 activating enzyme activity [GO:0019778]; Atg8 activating enzyme activity [GO:0019779]; protein homodimerization activity [GO:0042803]	autophagosome [GO:0005776]; axon [GO:0030424]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site [GO:0000407]; presynapse [GO:0098793]	GO:0000045; GO:0000407; GO:0000422; GO:0000423; GO:0001889; GO:0005737; GO:0005776; GO:0005829; GO:0005930; GO:0006497; GO:0006914; GO:0006995; GO:0007005; GO:0007628; GO:0008283; GO:0009267; GO:0009791; GO:0010508; GO:0010667; GO:0016236; GO:0019778; GO:0019779; GO:0021680; GO:0021860; GO:0021955; GO:0021987; GO:0030163; GO:0030424; GO:0031175; GO:0031396; GO:0031401; GO:0032436; GO:0032446; GO:0033554; GO:0034614; GO:0034727; GO:0035774; GO:0039689; GO:0042594; GO:0042752; GO:0042803; GO:0043065; GO:0043066; GO:0043068; GO:0043524; GO:0045087; GO:0045732; GO:0048471; GO:0050765; GO:0050877; GO:0051607; GO:0055013; GO:0060284; GO:0061024; GO:0061684; GO:0061739; GO:0062099; GO:0070257; GO:0071455; GO:0080144; GO:0090155; GO:0090156; GO:0090298; GO:0098691; GO:0098793; GO:0099504; GO:0140059; GO:1901526; GO:1903706; GO:1903860; GO:1903936; GO:2000786
GN019099	GN019099.1	Q8CDU4	28.8	711	824	790	3.05e-97	323	FXL13_MOUSE	F-box and leucine-rich repeat protein 13 (Dynein regulatory complex subunit 6) (F-box/LRR-repeat protein 13)	Mus musculus (Mouse)			centrosome [GO:0005813]	GO:0005813
GN019100	GN019100.1	Q04073	50.8	423	451	459	8.51e-115	347	P3A2_STRPU	DNA-binding protein P3A2	Strongylocentrotus purpuratus (Purple sea urchin)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357
GN019102	GN019102.1	Q2KHU0	58.0	224	225	225	4.33e-94	277	SERB_BOVIN	Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserine phosphohydrolase)	Bos taurus (Bovine)	L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]	L-phosphoserine phosphatase activity [GO:0036424]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]	GO:0000287; GO:0005829; GO:0006563; GO:0006564; GO:0036424
GN019103	GN019103.1	Q9D0W5	74.1	162	169	166	1.45e-92	269	PPIL1_MOUSE	Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase PPIL1)	Mus musculus (Mouse)	embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]	disordered domain specific binding [GO:0097718]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000398; GO:0000413; GO:0003755; GO:0005634; GO:0005681; GO:0005730; GO:0006457; GO:0071006; GO:0071007; GO:0071013; GO:0071014; GO:0071020; GO:0097718; GO:1990403
GN019108	GN019108.1	P12938	37.5	152	153	500	4.79e-26	105	CP2D3_RAT	Cytochrome P450 2D3 (EC 1.14.14.1) (CYPIID3) (Cytochrome P450-DB3) (Debrisoquine 4-hydroxylase)	Rattus norvegicus (Rat)	arachidonate metabolic process [GO:0019369]; liver development [GO:0001889]; xenobiotic metabolic process [GO:0006805]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	GO:0001889; GO:0004497; GO:0005506; GO:0005737; GO:0005789; GO:0006805; GO:0016712; GO:0019369; GO:0020037
GN019113	GN019113.1	Q8CJ11	35.4	384	738	1013	1.57e-57	215	AGRG2_RAT	Adhesion G protein-coupled receptor G2 (G protein-coupled receptor 64) (Rat epididymis-specific protein 6) (Re6) [Cleaved into: Adhesion G protein-coupled receptor G2, N-terminal fragment (ADGRG2 N-terminal fragment); Adhesion G protein-coupled receptor G2, C-terminal fragment (ADGRG2 C-terminal fragment)]	Rattus norvegicus (Rat)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; spermatid development [GO:0007286]	G protein-coupled receptor activity [GO:0004930]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0007189; GO:0007200; GO:0007286; GO:0016324
GN019114	GN019114.1	E1C7T6	64.8	247	249	318	1.01e-115	337	TYW5_CHICK	tRNA wybutosine-synthesizing protein 5 (EC 1.14.11.42) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase)	Gallus gallus (Chicken)	wybutosine biosynthetic process [GO:0031591]	iron ion binding [GO:0005506]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity [GO:0102524]		GO:0000049; GO:0005506; GO:0031591; GO:0042803; GO:0102524
GN019115	GN019115.1	O15050	31.5	1547	2505	2925	1.50e-189	650	TRNK1_HUMAN	TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog)	Homo sapiens (Human)				
GN019116	GN019116.1	P55083	48.1	235	308	255	2.98e-70	221	MFAP4_HUMAN	Microfibril-associated glycoprotein 4	Homo sapiens (Human)	cellular response to UV-B [GO:0071493]; elastic fiber assembly [GO:0048251]; regulation of collagen metabolic process [GO:0010712]; supramolecular fiber organization [GO:0097435]; UV protection [GO:0009650]		extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; microfibril [GO:0001527]; non-collagenous component of basement membrane [GO:0140144]	GO:0001527; GO:0005576; GO:0009650; GO:0010712; GO:0031012; GO:0048251; GO:0071493; GO:0097435; GO:0140144
GN019119	GN019119.1	A8WIP6	80.1	341	343	344	2.61e-205	568	CDK20_DANRE	Cyclin-dependent kinase 20 (EC 2.7.11.22) (Cell cycle-related kinase) (Cell division protein kinase 20)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]	cilium [GO:0005929]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0005929; GO:0060271; GO:0106310
GN019121	GN019121.1	Q86UV5	43.1	1113	1080	1035	1.27e-286	831	UBP48_HUMAN	Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48)	Homo sapiens (Human)	protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]	cilium [GO:0005929]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004197; GO:0004843; GO:0005634; GO:0005654; GO:0005739; GO:0005829; GO:0005929; GO:0016579; GO:0101005
GN019122	GN019122.1	Q62186	46.8	111	148	172	2.24e-32	115	SSRD_MOUSE	Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta)	Mus musculus (Mouse)			endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; Sec61 translocon complex [GO:0005784]	GO:0005783; GO:0005784; GO:0012505
GN019127	GN019127.1	Q16539	73.6	349	353	360	4.06e-190	531	MK14_HUMAN	Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)	Homo sapiens (Human)	3'-UTR-mediated mRNA stabilization [GO:0070935]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ionizing radiation [GO:0071479]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to UV-B [GO:0071493]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; chemotaxis [GO:0006935]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of hippo signaling [GO:0035331]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; osteoclast differentiation [GO:0030316]; p38MAPK cascade [GO:0038066]; platelet activation [GO:0030168]; positive regulation of cyclase activity [GO:0031281]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]; stress-induced premature senescence [GO:0090400]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase p38 binding [GO:0048273]; NFAT protein binding [GO:0051525]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]	GO:0000165; GO:0002862; GO:0004674; GO:0004707; GO:0004708; GO:0005524; GO:0005576; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006357; GO:0006935; GO:0007165; GO:0007166; GO:0010628; GO:0010831; GO:0016607; GO:0019899; GO:0019903; GO:0030168; GO:0030316; GO:0031098; GO:0031281; GO:0032735; GO:0034774; GO:0035331; GO:0035556; GO:0035924; GO:0038066; GO:0042770; GO:0045648; GO:0045663; GO:0048010; GO:0048273; GO:0051149; GO:0051403; GO:0051525; GO:0070935; GO:0071222; GO:0071223; GO:0071479; GO:0071493; GO:0090398; GO:0090400; GO:0098586; GO:0106310; GO:1900015; GO:1901741; GO:1904813; GO:2000379
GN019128	GN019128.1	Q61603	38.8	397	424	456	4.65e-91	285	GLRA4_MOUSE	Glycine receptor subunit alpha-4	Mus musculus (Mouse)	chloride transmembrane transport [GO:1902476]; response to amino acid [GO:0043200]	excitatory extracellular ligand-gated monoatomic ion channel activity [GO:0005231]; extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity [GO:0022824]	dendrite [GO:0030425]; glycinergic synapse [GO:0098690]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]	GO:0004888; GO:0005231; GO:0005886; GO:0016594; GO:0016934; GO:0022824; GO:0030425; GO:0043200; GO:0043204; GO:0045202; GO:0098690; GO:0099634; GO:1902476
GN019129	GN019129.1	Q5R5P3	49.0	665	738	743	4.36e-210	612	THNS1_PONAB	Threonine synthase-like 1 (TSH1)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)			cytoplasm [GO:0005737]	GO:0005737
GN019133	GN019133.1	Q13371	43.3	305	293	301	1.13e-74	233	PHLP_HUMAN	Phosducin-like protein (PHLP)	Homo sapiens (Human)	heterotrimeric G-protein complex assembly [GO:1902605]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; signal transduction [GO:0007165]		cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0005929; GO:0007165; GO:0008277; GO:0045880; GO:1902605
GN019134	GN019134.1	Q5RC32	29.9	291	1094	724	2.66e-16	87.8	SAXO6_PONAB	Stabilizer of axonemal microtubules 6 (Nuclear protein MDM1)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	negative regulation of centriole replication [GO:0046600]; retina development in camera-type eye [GO:0060041]	microtubule binding [GO:0008017]	centriole [GO:0005814]; centrosome [GO:0005813]; nucleus [GO:0005634]	GO:0005634; GO:0005813; GO:0005814; GO:0008017; GO:0046600; GO:0060041
GN019135	GN019135.1	Q4VSN1	75.4	228	235	885	2.14e-122	371	DUSTY_DANRE	Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5)	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to fibroblast growth factor stimulus [GO:0044344]; embryonic organ development [GO:0048568]; negative regulation of apoptotic process [GO:0043066]; notochord cell vacuolation [GO:0060036]; notochord morphogenesis [GO:0048570]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]	anchoring junction [GO:0070161]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004712; GO:0004713; GO:0005524; GO:0005737; GO:0005886; GO:0016323; GO:0016324; GO:0043066; GO:0044344; GO:0045743; GO:0048568; GO:0048570; GO:0060036; GO:0070161; GO:0070374; GO:0106310
GN019136	GN019136.1	Q9WTS8	40.8	174	196	335	2.08e-32	122	FCN1_RAT	Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)	Rattus norvegicus (Rat)	cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of interleukin-8 production [GO:0032757]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; pattern recognition receptor activity [GO:0038187]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]	GO:0001867; GO:0002752; GO:0003823; GO:0005102; GO:0005576; GO:0005886; GO:0007186; GO:0009986; GO:0031012; GO:0032757; GO:0033691; GO:0038187; GO:0097367; GO:0106139
GN019137	GN019137.1	Q8BUH1	65.1	149	149	149	5.29e-70	210	TXN4B_MOUSE	Thioredoxin-like protein 4B	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]; positive regulation of cell population proliferation [GO:0008284]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U12-type precatalytic spliceosome [GO:0071016]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]	GO:0000398; GO:0005634; GO:0005654; GO:0005681; GO:0005682; GO:0005829; GO:0008284; GO:0046540; GO:0071016
GN019138	GN019138.1	Q5U2R4	28.2	209	291	414	5.74e-13	72.0	TM10C_RAT	tRNA methyltransferase 10 homolog C (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221)	Rattus norvegicus (Rat)	mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial tRNA 3'-end processing [GO:1990180]; mitochondrial tRNA 5'-end processing [GO:0097745]; mitochondrial tRNA methylation [GO:0070901]; mitochondrial tRNA processing [GO:0090646]; mRNA processing [GO:0006397]; tRNA 3'-end processing [GO:0042780]; tRNA 3'-terminal CCA addition [GO:0001680]	identical protein binding [GO:0042802]; tRNA (adenine(9)-N1)-methyltransferase activity [GO:0160106]; tRNA (guanosine(9)-N1)-methyltransferase activity [GO:0052905]; tRNA binding [GO:0000049]	mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA methyltransferase complex [GO:0043527]	GO:0000049; GO:0000964; GO:0001680; GO:0005634; GO:0005654; GO:0005739; GO:0005759; GO:0006397; GO:0030678; GO:0042645; GO:0042780; GO:0042802; GO:0043527; GO:0052905; GO:0070901; GO:0090646; GO:0097745; GO:0160106; GO:1990180
GN019139	GN019139.1	Q9Y2B1	46.8	331	338	443	6.76e-101	307	RXLT1_HUMAN	Ribitol-5-phosphate xylosyltransferase 1 (EC 2.4.2.61) (Transmembrane protein 5) (UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase)	Homo sapiens (Human)	protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via mannose [GO:0035269]	ribitol beta-1,4-xylosyltransferase activity [GO:0120053]	catalytic complex [GO:1902494]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	GO:0000139; GO:0005794; GO:0005886; GO:0006493; GO:0035269; GO:0120053; GO:1902494
GN019142	GN019142.1	Q7T0P7	39.1	202	249	235	4.26e-40	141	ATP23_XENLA	Mitochondrial inner membrane protease ATP23 homolog (EC 3.4.24.-)	Xenopus laevis (African clawed frog)	mitochondrial protein processing [GO:0034982]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]	metalloendopeptidase activity [GO:0004222]	mitochondrion [GO:0005739]	GO:0004222; GO:0005739; GO:0033615; GO:0034982
GN019143	GN019143.1	C5FP68	32.1	212	684	674	8.17e-27	119	SCONB_ARTOC	Probable E3 ubiquitin ligase complex SCF subunit sconB (Sulfur controller B) (Sulfur metabolite repression control protein B)	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)	protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	SCF ubiquitin ligase complex [GO:0019005]	GO:0016567; GO:0019005; GO:0031146; GO:1990756
GN019144	GN019144.1	C5FP68	29.7	182	420	674	1.07e-16	85.9	SCONB_ARTOC	Probable E3 ubiquitin ligase complex SCF subunit sconB (Sulfur controller B) (Sulfur metabolite repression control protein B)	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)	protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	SCF ubiquitin ligase complex [GO:0019005]	GO:0016567; GO:0019005; GO:0031146; GO:1990756
GN019145	GN019145.1	Q6P542	64.3	597	650	837	5.22e-256	729	ABCF1_MOUSE	ATP-binding cassette sub-family F member 1	Mus musculus (Mouse)	positive regulation of translation [GO:0045727]; translational initiation [GO:0006413]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ribosome binding [GO:0043022]; translation activator activity [GO:0008494]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]	GO:0005524; GO:0005635; GO:0005654; GO:0005737; GO:0005829; GO:0005840; GO:0006413; GO:0008494; GO:0016887; GO:0043022; GO:0045727
GN019146	GN019146.1	Q5BN45	45.1	82	121	167	5.63e-18	77.8	PIRC1_MOUSE	Piercer of microtubule wall 1 protein (Pierce1) (p53-induced expression in RB-null cells protein 1)	Mus musculus (Mouse)	axoneme assembly [GO:0035082]; cellular response to UV-C [GO:0071494]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; DNA damage response [GO:0006974]; establishment of left/right asymmetry [GO:0061966]; flagellated sperm motility [GO:0030317]; regulation of gene expression [GO:0010468]		axonemal A tubule inner sheath [GO:0160111]; axonemal microtubule [GO:0005879]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]	GO:0003341; GO:0005634; GO:0005737; GO:0005879; GO:0006974; GO:0007368; GO:0010468; GO:0030317; GO:0035082; GO:0036126; GO:0061966; GO:0071494; GO:0160111
GN019147	GN019147.1	Q6P542	65.5	597	723	837	5.12e-263	750	ABCF1_MOUSE	ATP-binding cassette sub-family F member 1	Mus musculus (Mouse)	positive regulation of translation [GO:0045727]; translational initiation [GO:0006413]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ribosome binding [GO:0043022]; translation activator activity [GO:0008494]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]	GO:0005524; GO:0005635; GO:0005654; GO:0005737; GO:0005829; GO:0005840; GO:0006413; GO:0008494; GO:0016887; GO:0043022; GO:0045727
GN019148	GN019148.1	Q16656	41.5	118	772	503	4.19e-14	79.3	NRF1_HUMAN	Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal)	Homo sapiens (Human)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0005654; GO:0006357; GO:0042803; GO:0045944; GO:0070062
GN019149	GN019149.1	Q16656	36.6	112	855	503	2.12e-14	80.5	NRF1_HUMAN	Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal)	Homo sapiens (Human)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0005654; GO:0006357; GO:0042803; GO:0045944; GO:0070062
GN019152	GN019152.1	Q13569	57.5	240	656	410	7.90e-75	249	TDG_HUMAN	G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (Thymine-DNA glycosylase) (hTDG)	Homo sapiens (Human)	base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; chromosomal 5-methylcytosine DNA demethylation, oxidation pathway [GO:0141167]; depyrimidination [GO:0045008]; epigenetic regulation of gene expression [GO:0040029]; regulation of embryonic development [GO:0045995]	ATP binding [GO:0005524]; chloride ion binding [GO:0031404]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]; double-stranded DNA binding [GO:0003690]; G/T mismatch-specific thymine-DNA glycosylase activity [GO:0141016]; G/U mismatch-specific uracil-DNA glycosylase activity [GO:0043739]; magnesium ion binding [GO:0000287]; mismatched DNA binding [GO:0030983]; nucleic acid binding [GO:0003676]; protein kinase C binding [GO:0005080]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; sodium ion binding [GO:0031402]; SUMO binding [GO:0032183]; transcription coregulator activity [GO:0003712]; uracil DNA N-glycosylase activity [GO:0004844]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0000287; GO:0003676; GO:0003677; GO:0003684; GO:0003690; GO:0003712; GO:0004844; GO:0005080; GO:0005524; GO:0005634; GO:0005654; GO:0006284; GO:0006285; GO:0008263; GO:0016605; GO:0019104; GO:0030983; GO:0031402; GO:0031404; GO:0032183; GO:0040029; GO:0043739; GO:0045008; GO:0045995; GO:0141016; GO:0141167
GN019153	GN019153.1	P42325	66.1	186	187	190	2.23e-90	265	NCAH_DROME	Neurocalcin homolog (DrosNCa)	Drosophila melanogaster (Fruit fly)	negative regulation of neuronal signal transduction [GO:1902848]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; regulation of signal transduction [GO:0009966]	calcium ion binding [GO:0005509]		GO:0005509; GO:0009966; GO:0045938; GO:1902848
GN019154	GN019154.1	Q3SZP5	43.3	656	711	660	1.48e-167	499	ACOX1_BOVIN	Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]	Bos taurus (Bovine)	fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid catabolic process [GO:0009062]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; hydrogen peroxide biosynthetic process [GO:0050665]; lipid metabolic process [GO:0006629]; prostaglandin metabolic process [GO:0006693]; very long-chain fatty acid beta-oxidation [GO:0140493]; very long-chain fatty acid metabolic process [GO:0000038]	acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; long-chain fatty acyl-CoA oxidase activity [GO:0120524]; medium-chain fatty acyl-CoA oxidase activity [GO:0120523]; protein homodimerization activity [GO:0042803]; very-long-chain fatty acyl-CoA oxidase activity [GO:0044535]	peroxisome [GO:0005777]	GO:0000038; GO:0003997; GO:0005504; GO:0005777; GO:0006091; GO:0006629; GO:0006693; GO:0009062; GO:0019395; GO:0033540; GO:0042803; GO:0044535; GO:0050660; GO:0050665; GO:0071949; GO:0120523; GO:0120524; GO:0140493
GN019156	GN019156.1	Q1JQ66	62.5	224	240	313	7.49e-90	270	S35E3_DANRE	Solute carrier family 35 member E3	Danio rerio (Zebrafish) (Brachydanio rerio)			membrane [GO:0016020]	GO:0016020
GN019157	GN019157.1	Q6DJI9	73.1	130	213	218	4.65e-67	208	ZCRB1_XENLA	Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) (U11/U12 snRNP 31 kDa protein)	Xenopus laevis (African clawed frog)	mRNA splicing, via spliceosome [GO:0000398]	RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	U12-type spliceosomal complex [GO:0005689]	GO:0000398; GO:0003723; GO:0005689; GO:0008270
GN019158	GN019158.1	Q7Z6B7	47.4	777	1110	1085	1.99e-217	656	SRGP1_HUMAN	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13)	Homo sapiens (Human)	negative regulation of cell migration [GO:0030336]; nervous system development [GO:0007399]; regulation of synapse assembly [GO:0051963]; signal transduction [GO:0007165]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]	GO:0005096; GO:0005829; GO:0007165; GO:0007399; GO:0030336; GO:0031267; GO:0051963
GN019159	GN019159.1	Q16656	36.6	112	853	503	2.11e-14	80.5	NRF1_HUMAN	Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal)	Homo sapiens (Human)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0005654; GO:0006357; GO:0042803; GO:0045944; GO:0070062
GN019160	GN019160.1	Q16656	45.6	68	103	503	2.48e-10	58.9	NRF1_HUMAN	Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal)	Homo sapiens (Human)	positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001228; GO:0005634; GO:0005654; GO:0006357; GO:0042803; GO:0045944; GO:0070062
GN019164	GN019164.1	Q6JEL2	40.8	346	589	608	7.18e-86	282	KLH10_HUMAN	Kelch-like protein 10	Homo sapiens (Human)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]	GO:0005737; GO:0016567; GO:0031463; GO:0043161; GO:1990756
GN019165	GN019165.1	Q96M69	45.2	62	299	825	8.13e-10	63.2	LRGUK_HUMAN	Leucine-rich repeat and guanylate kinase domain-containing protein	Homo sapiens (Human)	axoneme assembly [GO:0035082]; spermatogenesis [GO:0007283]		acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; manchette [GO:0002177]	GO:0001669; GO:0002177; GO:0005829; GO:0007283; GO:0035082
GN019168	GN019168.1	Q00537	67.6	445	544	523	8.13e-210	595	CDK17_HUMAN	Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2)	Homo sapiens (Human)	protein phosphorylation [GO:0006468]; regulation of cell cycle phase transition [GO:1901987]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]	GO:0000307; GO:0004672; GO:0004693; GO:0005524; GO:0005737; GO:0006468; GO:0106310; GO:1901987
GN019169	GN019169.1	Q6NRH0	64.4	351	563	564	4.35e-158	466	KLH12_XENLA	Kelch-like protein 12	Xenopus laevis (African clawed frog)	COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; Wnt signaling pathway [GO:0016055]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]	GO:0005737; GO:0006513; GO:0006888; GO:0014029; GO:0014032; GO:0016055; GO:0030127; GO:0030134; GO:0031463; GO:0043161; GO:0048208; GO:1990756
GN019170	GN019170.1	Q9D581	35.7	129	141	132	2.10e-22	89.0	EFC10_MOUSE	EF-hand calcium-binding domain-containing protein 10	Mus musculus (Mouse)		calcium ion binding [GO:0005509]		GO:0005509
GN019171	GN019171.1	P27473	28.2	436	468	444	1.11e-40	154	IFI44_PANTR	Interferon-induced protein 44 (Antigen p44) (Non-A non-B hepatitis-associated microtubular aggregates protein)	Pan troglodytes (Chimpanzee)	immune response [GO:0006955]; response to virus [GO:0009615]		cytoplasm [GO:0005737]	GO:0005737; GO:0006955; GO:0009615
GN019173	GN019173.1	Q53G44	25.9	490	496	452	1.23e-43	163	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN019174	GN019174.1	Q53G44	32.3	158	185	452	4.74e-24	100	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN019175	GN019175.1	Q53G44	29.7	138	163	452	3.72e-18	83.6	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN019176	GN019176.1	P33945	62.9	340	371	360	1.93e-162	462	WNT5B_XENLA	Protein Wnt-5b (Protein Wnt-5c) (XWnt-5C)	Xenopus laevis (African clawed frog)	canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; muscle cell differentiation [GO:0042692]; neuron differentiation [GO:0030182]; positive regulation of convergent extension involved in gastrulation [GO:1904105]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]	cytokine activity [GO:0005125]; frizzled binding [GO:0005109]	extracellular region [GO:0005576]	GO:0005109; GO:0005125; GO:0005576; GO:0030182; GO:0042692; GO:0045165; GO:0060070; GO:1904105; GO:2000052
GN019177	GN019177.1	Q53G44	30.7	446	477	452	1.18e-49	179	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN019182	GN019182.1	Q7ZVX6	73.3	431	451	462	2.32e-244	677	UBA3_DANRE	NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein neddylation [GO:0045116]	NEDD8 activating enzyme activity [GO:0019781]	nucleus [GO:0005634]	GO:0005634; GO:0019781; GO:0045116
GN019183	GN019183.1	Q56P28	45.1	173	178	188	1.43e-47	156	PRAF3_PIG	PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5)	Sus scrofa (Pig)	L-glutamate transmembrane transport [GO:0015813]; negative regulation of L-glutamate import across plasma membrane [GO:0002037]; negative regulation of transport [GO:0051051]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0002037; GO:0005737; GO:0005789; GO:0005856; GO:0005886; GO:0015813; GO:0016020; GO:0051051
GN019188	GN019188.1	P51957	37.9	261	417	841	4.05e-46	173	NEK4_HUMAN	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)	Homo sapiens (Human)	DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; mitotic cell cycle [GO:0000278]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of monoatomic cation transmembrane transport [GO:1904062]	ATP binding [GO:0005524]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0000278; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0005929; GO:0006468; GO:0006974; GO:0030145; GO:0035556; GO:0045893; GO:0090263; GO:0106310; GO:1904062; GO:2000772
GN019189	GN019189.1	P49432	73.8	344	360	359	1.55e-184	517	ODPB_RAT	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)	Rattus norvegicus (Rat)	pyruvate decarboxylation to acetyl-CoA [GO:0006086]	pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; pyruvate dehydrogenase complex [GO:0045254]	GO:0004739; GO:0005739; GO:0005759; GO:0006086; GO:0045254
GN019190	GN019190.1	P16036	71.6	352	379	356	1.94e-182	513	S25A3_RAT	Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP)	Rattus norvegicus (Rat)	mitochondrial phosphate ion transmembrane transport [GO:1990547]; phosphate ion transmembrane transport [GO:0035435]	phosphate transmembrane transporter activity [GO:0005315]; phosphate:proton symporter activity [GO:0015317]; protein-containing complex binding [GO:0044877]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005315; GO:0005739; GO:0005743; GO:0015317; GO:0035435; GO:0044877; GO:1990547
GN019192	GN019192.1	Q58DA6	58.0	307	358	393	2.59e-102	310	S35A2_BOVIN	UDP-galactose translocator (Solute carrier family 35 member A2) (UDP-galactose transporter) (UDP-Gal-Tr) (UGT)	Bos taurus (Bovine)	UDP-galactose transmembrane transport [GO:0072334]	UDP-galactose transmembrane transporter activity [GO:0005459]	Golgi membrane [GO:0000139]	GO:0000139; GO:0005459; GO:0072334
GN019193	GN019193.1	Q9R0M8	57.5	322	345	390	5.18e-111	331	S35A2_MOUSE	UDP-galactose translocator (Solute carrier family 35 member A2) (UDP-galactose transporter) (UDP-Gal-Tr) (UGT) (mUGT1)	Mus musculus (Mouse)	UDP-galactose transmembrane transport [GO:0072334]	UDP-galactose transmembrane transporter activity [GO:0005459]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]	GO:0000139; GO:0005459; GO:0005654; GO:0005783; GO:0005789; GO:0005794; GO:0072334
GN019194	GN019194.1	P52907	64.5	276	1356	286	1.73e-116	369	CAZA1_HUMAN	F-actin-capping protein subunit alpha-1 (CapZ alpha-1)	Homo sapiens (Human)	barbed-end actin filament capping [GO:0051016]; cell junction assembly [GO:0034329]; protein-containing complex assembly [GO:0065003]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; cadherin binding [GO:0045296]	actin cytoskeleton [GO:0015629]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; F-actin capping protein complex [GO:0008290]; WASH complex [GO:0071203]	GO:0003779; GO:0005576; GO:0005829; GO:0005856; GO:0008290; GO:0015629; GO:0030863; GO:0034329; GO:0045296; GO:0051015; GO:0051016; GO:0065003; GO:0070062; GO:0071203
GN019195	GN019195.1	Q9CQM0	35.5	242	268	213	1.85e-41	144	NICN1_MOUSE	Nicolin-1 (Tubulin polyglutamylase complex subunit 5) (PGs5) (p24)	Mus musculus (Mouse)			cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005829
GN019196	GN019196.1	A5WUT8	28.8	1091	1130	2532	1.12e-143	483	EPG5_DANRE	Ectopic P granules protein 5 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	autophagosome maturation [GO:0097352]; autophagosome-lysosome fusion [GO:0061909]; intestinal epithelial cell development [GO:0060576]; intestinal stem cell homeostasis [GO:0036335]		cytoplasm [GO:0005737]	GO:0005737; GO:0036335; GO:0060576; GO:0061909; GO:0097352
GN019199	GN019199.1	Q5RB02	44.4	232	250	463	9.03e-63	206	CATC_PONAB	Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)]	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	proteolysis [GO:0006508]	cysteine-type peptidase activity [GO:0008234]; dipeptidyl-peptidase activity [GO:0008239]	lysosome [GO:0005764]	GO:0005764; GO:0006508; GO:0008234; GO:0008239
GN019200	GN019200.1	Q4KM33	26.0	246	329	350	6.49e-18	86.7	PLEK_RAT	Pleckstrin	Rattus norvegicus (Rat)	actin cytoskeleton organization [GO:0030036]; cortical actin cytoskeleton organization [GO:0030866]; hematopoietic progenitor cell differentiation [GO:0002244]; inositol phosphate metabolic process [GO:0043647]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of inositol phosphate biosynthetic process [GO:0010920]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; phospholipase C-inhibiting G protein-coupled receptor signaling pathway [GO:0030845]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of integrin activation [GO:0033625]; positive regulation of platelet activation [GO:0010572]; protein secretion by platelet [GO:0070560]; regulation of cell diameter [GO:0060305]; ruffle organization [GO:0031529]; thrombin-activated receptor signaling pathway [GO:0070493]; vesicle docking involved in exocytosis [GO:0006904]	phosphatase activator activity [GO:0019211]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]	GO:0002244; GO:0002576; GO:0005080; GO:0005737; GO:0005886; GO:0006904; GO:0007200; GO:0007229; GO:0010572; GO:0010920; GO:0019211; GO:0030036; GO:0030836; GO:0030845; GO:0030866; GO:0031529; GO:0032233; GO:0032587; GO:0033625; GO:0035556; GO:0042803; GO:0043325; GO:0043647; GO:0045744; GO:0060305; GO:0070493; GO:0070495; GO:0070527; GO:0070560
GN019202	GN019202.1	P14650	31.8	619	596	914	7.18e-88	295	PERT_RAT	Thyroid peroxidase (TPO) (EC 1.11.1.8)	Rattus norvegicus (Rat)	cellular response to nitric oxide [GO:0071732]; embryonic hemopoiesis [GO:0035162]; response to lipid [GO:0033993]; response to oxidative stress [GO:0006979]; thyroid hormone generation [GO:0006590]	calcium ion binding [GO:0005509]; heme binding [GO:0020037]; iodide peroxidase activity [GO:0004447]; peroxidase activity [GO:0004601]	cell surface [GO:0009986]; membrane [GO:0016020]	GO:0004447; GO:0004601; GO:0005509; GO:0006590; GO:0006979; GO:0009986; GO:0016020; GO:0020037; GO:0033993; GO:0035162; GO:0071732
GN019203	GN019203.1	G5ECP4	42.8	320	1112	485	8.88e-58	211	PIK1_CAEEL	Pelle-like serine/threonine-protein kinase pik-1 (EC 2.7.11.1)	Caenorhabditis elegans	cytokine-mediated signaling pathway [GO:0019221]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; Toll signaling pathway [GO:0008063]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	plasma membrane [GO:0005886]	GO:0004674; GO:0005524; GO:0005886; GO:0008063; GO:0019221; GO:0031663; GO:0035556; GO:0045087; GO:0106310
GN019204	GN019204.1	F1N206	75.6	468	497	509	3.88e-257	713	DLDH_BOVIN	Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase)	Bos taurus (Bovine)	2-oxoglutarate decarboxylation to succinyl-CoA [GO:0120551]; 2-oxoglutarate metabolic process [GO:0006103]; branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA [GO:0120552]; L-lysine catabolic process [GO:0019477]; pyruvate decarboxylation to acetyl-CoA [GO:0006086]	dihydrolipoyl dehydrogenase (NADH) activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660]	acrosomal matrix [GO:0043159]; branched-chain alpha-ketoacid dehydrogenase complex [GO:0160157]; mitochondrial matrix [GO:0005759]; motile cilium [GO:0031514]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; oxoadipate dehydrogenase complex [GO:0160167]; oxoglutarate dehydrogenase complex [GO:0045252]; pyruvate dehydrogenase complex [GO:0045254]	GO:0004148; GO:0005634; GO:0005654; GO:0005759; GO:0006086; GO:0006103; GO:0019477; GO:0031514; GO:0043159; GO:0045252; GO:0045254; GO:0050660; GO:0120551; GO:0120552; GO:0160157; GO:0160167
GN019205	GN019205.1	P53356	32.0	150	422	757	1.03e-10	67.4	HTK16_HYDVU	Tyrosine-protein kinase HTK16 (EC 2.7.10.2)	Hydra vulgaris (Hydra) (Hydra attenuata)		ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]		GO:0004715; GO:0005524
GN019206	GN019206.1	Q9V4A7	34.8	2020	1901	2051	0.0	1002	PLXB_DROME	Plexin-B	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; motor neuron axon guidance [GO:0008045]; negative regulation of cell adhesion [GO:0007162]; olfactory bulb axon guidance [GO:0071678]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; sensory neuron axon guidance [GO:0097374]; synapse assembly [GO:0007416]	semaphorin receptor activity [GO:0017154]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	GO:0002116; GO:0005886; GO:0007162; GO:0007411; GO:0007416; GO:0008045; GO:0008360; GO:0017154; GO:0030334; GO:0030425; GO:0050772; GO:0070593; GO:0071526; GO:0071678; GO:0097374
GN019207	GN019207.1	P82198	32.1	271	302	683	4.97e-34	134	BGH3_MOUSE	Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3)	Mus musculus (Mouse)	angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; chondrocyte differentiation [GO:0002062]; extracellular matrix organization [GO:0030198]; homophilic cell-cell adhesion [GO:0007156]	cell adhesion molecule binding [GO:0050839]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; identical protein binding [GO:0042802]	basement membrane [GO:0005604]; cell periphery [GO:0071944]; elastic fiber [GO:0071953]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]; trans-Golgi network [GO:0005802]	GO:0001525; GO:0002062; GO:0005518; GO:0005576; GO:0005604; GO:0005802; GO:0007155; GO:0007156; GO:0030198; GO:0031012; GO:0042802; GO:0050839; GO:0050840; GO:0071944; GO:0071953; GO:0140144
GN019208	GN019208.1	Q86UP9	43.7	215	255	236	5.01e-61	195	LHPL3_HUMAN	LHFPL tetraspan subfamily member 3 protein (Lipoma HMGIC fusion partner-like 3 protein)	Homo sapiens (Human)	sensory perception of sound [GO:0007605]		plasma membrane [GO:0005886]	GO:0005886; GO:0007605
GN019209	GN019209.1	A1YFA7	35.8	321	285	265	3.85e-28	112	PQBP1_GORGO	Polyglutamine-binding protein 1 (PQBP-1) (Polyglutamine tract-binding protein 1)	Gorilla gorilla gorilla (Western lowland gorilla)	activation of innate immune response [GO:0002218]; alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; neuron projection development [GO:0031175]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type I interferon production [GO:0032481]	double-stranded DNA binding [GO:0003690]; ribonucleoprotein complex binding [GO:0043021]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; neuronal ribonucleoprotein granule [GO:0071598]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]	GO:0000380; GO:0002218; GO:0002230; GO:0003690; GO:0005737; GO:0010494; GO:0016604; GO:0016607; GO:0031175; GO:0032481; GO:0043021; GO:0051607; GO:0071360; GO:0071598
GN019210	GN019210.1	Q32LN1	85.8	183	182	183	1.17e-112	321	UBE2H_BOVIN	Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (Ubiquitin carrier protein H) (Ubiquitin-protein ligase H)	Bos taurus (Bovine)	protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]	ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]		GO:0000209; GO:0004842; GO:0061631; GO:0070936; GO:0070979
GN019211	GN019211.1	Q8BH65	60.7	549	1819	605	1.36e-225	680	DEN6A_MOUSE	Protein DENND6A (DENN domain-containing protein 6A)	Mus musculus (Mouse)	positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytoplasm [GO:0005737]; recycling endosome [GO:0055037]	GO:0005085; GO:0005737; GO:0055037; GO:2000049
GN019212	GN019212.1	Q641C8	58.6	263	294	266	5.73e-105	309	SAMC_XENLA	Mitochondrial S-adenosylmethionine carrier protein (SAM carrier) (Solute carrier family 25 member 26)	Xenopus laevis (African clawed frog)	mitochondrial S-adenosyl-L-methionine transmembrane transport [GO:1990543]; S-adenosyl-L-methionine transport [GO:0015805]	S-adenosyl-L-methionine transmembrane transporter activity [GO:0000095]; S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity [GO:0180003]	mitochondrial inner membrane [GO:0005743]	GO:0000095; GO:0005743; GO:0015805; GO:0180003; GO:1990543
GN019215	GN019215.1	Q8UUR3	33.8	151	166	174	6.31e-14	68.9	CYGB1_DANRE	Cytoglobin-1 (Nitric oxygen dioxygenase CYGB) (EC 1.14.12.-) (Nitrite reductase CYGB) (EC 1.7.-.-) (Pseudoperoxidase CYGB) (EC 1.11.1.-) (Superoxide dismutase CYGB) (EC 1.15.1.1)	Danio rerio (Zebrafish) (Brachydanio rerio)	neural crest cell development [GO:0014032]; nitric oxide catabolic process [GO:0046210]; oxygen transport [GO:0015671]; regulation of neural crest cell differentiation [GO:1905292]; regulation of response to oxidative stress [GO:1902882]; removal of superoxide radicals [GO:0019430]; response to cadmium ion [GO:0046686]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; nitric oxide dioxygenase activity, heme protein as donor [GO:0141118]; nitrite reductase activity [GO:0098809]; oxidoreductase activity [GO:0016491]; oxygen binding [GO:0019825]; superoxide dismutase activity [GO:0004784]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004784; GO:0005506; GO:0005634; GO:0005737; GO:0014032; GO:0015671; GO:0016491; GO:0019430; GO:0019825; GO:0020037; GO:0046210; GO:0046686; GO:0098809; GO:0141118; GO:1902882; GO:1905292
GN019219	GN019219.1	P40682	28.2	433	404	468	1.56e-28	119	VAS1_BOVIN	V-type proton ATPase subunit S1 (V-ATPase subunit S1) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1)	Bos taurus (Bovine)	cellular response to increased oxygen levels [GO:0036295]; intracellular iron ion homeostasis [GO:0006879]; positive regulation of TORC1 signaling [GO:1904263]		clathrin-coated vesicle membrane [GO:0030665]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; proton-transporting V-type ATPase complex [GO:0033176]; synaptic vesicle membrane [GO:0030672]	GO:0005789; GO:0006879; GO:0030665; GO:0030672; GO:0033116; GO:0033176; GO:0036295; GO:1904263
GN019224	GN019224.1	P74897	28.2	149	157	137	1.14e-09	56.6	YQA3_THEAQ	Universal stress protein in QAH/OAS sulfhydrylase 3'region (USP)	Thermus aquaticus				
GN019226	GN019226.1	B9FAF3	46.1	358	678	1080	3.10e-93	315	KN14E_ORYSJ	Kinesin-like protein KIN-14E	Oryza sativa subsp. japonica (Rice)	microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	microtubule cytoskeleton [GO:0015630]	GO:0003777; GO:0005524; GO:0007017; GO:0007018; GO:0008017; GO:0015630
GN019231	GN019231.1	Q9HBM0	27.4	634	872	779	8.56e-30	130	VEZA_HUMAN	Vezatin	Homo sapiens (Human)	cell-cell adhesion [GO:0098609]	myosin binding [GO:0017022]	acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilia ankle link complex [GO:0002142]; stereocilium membrane [GO:0060171]	GO:0001669; GO:0002142; GO:0005634; GO:0005654; GO:0005886; GO:0005912; GO:0017022; GO:0060171; GO:0098609
GN019234	GN019234.1	Q8MJC3	29.9	204	316	277	3.82e-12	68.9	CASP3_RABIT	Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]	Oryctolagus cuniculus (Rabbit)	erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of neuron apoptotic process [GO:0043525]; protein maturation [GO:0051604]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; response to UV [GO:0009411]; synapse pruning [GO:0098883]	cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]	cytoplasm [GO:0005737]; death-inducing signaling complex [GO:0031264]	GO:0004175; GO:0004197; GO:0005737; GO:0006508; GO:0009411; GO:0030182; GO:0030216; GO:0030218; GO:0031264; GO:0031647; GO:0043525; GO:0051604; GO:0097194; GO:0098883; GO:1902004
GN019235	GN019235.1	Q9HBM0	26.4	821	767	779	3.37e-30	131	VEZA_HUMAN	Vezatin	Homo sapiens (Human)	cell-cell adhesion [GO:0098609]	myosin binding [GO:0017022]	acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilia ankle link complex [GO:0002142]; stereocilium membrane [GO:0060171]	GO:0001669; GO:0002142; GO:0005634; GO:0005654; GO:0005886; GO:0005912; GO:0017022; GO:0060171; GO:0098609
GN019236	GN019236.1	F1R4Y7	31.7	679	774	716	1.64e-75	262	CEP83_DANRE	Centrosomal protein of 83 kDa (Cep83) (Coiled-coil domain-containing protein 41)	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; establishment of centrosome localization [GO:0051660]		centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; Golgi apparatus [GO:0005794]	GO:0005794; GO:0005813; GO:0005814; GO:0051660; GO:0060271; GO:0097539
GN019237	GN019237.1	M9PBE2	61.9	134	493	473	2.56e-49	179	HAKAI_DROME	E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27)	Drosophila melanogaster (Fruit fly)	actin filament organization [GO:0007015]; chitin-based cuticle development [GO:0040003]; dorsal closure [GO:0007391]; epithelial cell migration, open tracheal system [GO:0007427]; epithelium development [GO:0060429]; female sex determination [GO:0030237]; head involution [GO:0008258]; midgut development [GO:0007494]; protein ubiquitination [GO:0016567]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of cell adhesion [GO:0030155]; segmentation [GO:0035282]; sex differentiation [GO:0007548]	cadherin binding [GO:0045296]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	GO:0000381; GO:0004842; GO:0005634; GO:0005829; GO:0005886; GO:0007015; GO:0007391; GO:0007427; GO:0007494; GO:0007548; GO:0008258; GO:0008270; GO:0016567; GO:0030155; GO:0030237; GO:0031410; GO:0035282; GO:0036396; GO:0040003; GO:0045296; GO:0048471; GO:0060429; GO:0061630
GN019239	GN019239.1	Q5S007	29.5	2687	2663	2527	3.01e-290	932	LRRK2_HUMAN	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	Homo sapiens (Human)	calcium-mediated signaling [GO:0019722]; canonical Wnt signaling pathway [GO:0060070]; cellular response to curcumin [GO:1904644]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; endoplasmic reticulum organization [GO:0007029]; excitatory postsynaptic potential [GO:0060079]; exploration behavior [GO:0035640]; Golgi organization [GO:0007030]; GTP metabolic process [GO:0046039]; intracellular distribution of mitochondria [GO:0048312]; intracellular protein localization [GO:0008104]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; locomotory exploration behavior [GO:0035641]; lysosome organization [GO:0007040]; MAPK cascade [GO:0000165]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of GTPase activity [GO:0034260]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of macroautophagy [GO:0016242]; negative regulation of motile cilium assembly [GO:1905504]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein localization to mitochondrion [GO:1903748]; negative regulation of protein processing [GO:0010955]; neuromuscular junction development [GO:0007528]; neuron projection arborization [GO:0140058]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of tumor necrosis factor production [GO:0032760]; protein autophosphorylation [GO:0046777]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to mitochondrion [GO:0070585]; protein phosphorylation [GO:0006468]; regulation of autophagy [GO:0010506]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of CAMKK-AMPK signaling cascade [GO:1905289]; regulation of cAMP/PKA signal transduction [GO:0141161]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell projection organization [GO:0031344]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of kidney size [GO:0035564]; regulation of locomotion [GO:0040012]; regulation of membrane potential [GO:0042391]; regulation of mitochondrial depolarization [GO:0051900]; regulation of mitochondrial fission [GO:0090140]; regulation of neuroblast proliferation [GO:1902692]; regulation of neuron maturation [GO:0014041]; regulation of protein stability [GO:0031647]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle transport [GO:1902803]; response to oxidative stress [GO:0006979]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; striatum development [GO:0021756]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; Wnt signalosome assembly [GO:1904887]	actin binding [GO:0003779]; ATP binding [GO:0005524]; beta-catenin destruction complex binding [GO:1904713]; clathrin binding [GO:0030276]; co-receptor binding [GO:0039706]; GTP binding [GO:0005525]; GTP-dependent protein kinase activity [GO:0034211]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; microtubule binding [GO:0008017]; peroxidase inhibitor activity [GO:0036479]; protein homodimerization activity [GO:0042803]; protein kinase A binding [GO:0051018]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor complex adaptor activity [GO:0030159]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]; transmembrane transporter binding [GO:0044325]; tubulin binding [GO:0015631]	amphisome [GO:0044753]; autolysosome [GO:0044754]; axon [GO:0030424]; caveola neck [GO:0099400]; cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; growth cone [GO:0030426]; Lewy body [GO:0097413]; lysosome [GO:0005764]; microvillus [GO:0005902]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body, internal vesicle [GO:0097487]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic cytosol [GO:0099523]; ribonucleoprotein complex [GO:1990904]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; trans-Golgi network [GO:0005802]; Wnt signalosome [GO:1990909]	GO:0000139; GO:0000149; GO:0000165; GO:0000287; GO:0003779; GO:0003924; GO:0004672; GO:0004674; GO:0004706; GO:0004709; GO:0005096; GO:0005524; GO:0005525; GO:0005576; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005764; GO:0005768; GO:0005783; GO:0005789; GO:0005794; GO:0005798; GO:0005802; GO:0005829; GO:0005886; GO:0005902; GO:0006468; GO:0006897; GO:0006979; GO:0007005; GO:0007029; GO:0007030; GO:0007040; GO:0007254; GO:0007266; GO:0007283; GO:0007528; GO:0008017; GO:0008104; GO:0008340; GO:0009267; GO:0010506; GO:0010508; GO:0010955; GO:0010977; GO:0014041; GO:0015631; GO:0016242; GO:0016301; GO:0017075; GO:0019722; GO:0021756; GO:0021772; GO:0022028; GO:0030159; GO:0030276; GO:0030424; GO:0030425; GO:0030426; GO:0030672; GO:0031267; GO:0031344; GO:0031398; GO:0031410; GO:0031647; GO:0031966; GO:0032436; GO:0032473; GO:0032760; GO:0032839; GO:0034211; GO:0034260; GO:0034599; GO:0034614; GO:0035542; GO:0035556; GO:0035564; GO:0035640; GO:0035641; GO:0036479; GO:0039706; GO:0040012; GO:0042391; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0043068; GO:0043195; GO:0043204; GO:0043410; GO:0044325; GO:0044753; GO:0044754; GO:0045335; GO:0046039; GO:0046777; GO:0048312; GO:0048812; GO:0051018; GO:0051646; GO:0051900; GO:0051966; GO:0060070; GO:0060079; GO:0060159; GO:0060161; GO:0060628; GO:0060828; GO:0061001; GO:0070062; GO:0070585; GO:0070971; GO:0070973; GO:0071287; GO:0090140; GO:0090263; GO:0090394; GO:0097413; GO:0097487; GO:0098794; GO:0098978; GO:0099400; GO:0099523; GO:0106310; GO:0140058; GO:0141161; GO:1900242; GO:1900244; GO:1901030; GO:1902236; GO:1902499; GO:1902692; GO:1902803; GO:1902823; GO:1902902; GO:1903351; GO:1903748; GO:1903980; GO:1904644; GO:1904713; GO:1904887; GO:1905279; GO:1905289; GO:1905504; GO:1990904; GO:1990909; GO:2000172; GO:2000300; GO:2000377
GN019240	GN019240.1	Q08BB2	47.6	456	505	522	5.44e-149	439	P2012_DANRE	N-fatty-acyl-amino acid synthase/hydrolase PM20D1.2 (EC 3.5.1.114) (EC 3.5.1.14) (Peptidase M20 domain-containing protein 1.2)	Danio rerio (Zebrafish) (Brachydanio rerio)	adaptive thermogenesis [GO:1990845]; amino acid metabolic process [GO:0006520]; energy homeostasis [GO:0097009]; fatty acid metabolic process [GO:0006631]; lipid metabolic process [GO:0006629]; respiratory electron transport chain [GO:0022904]	aminoacylase activity [GO:0004046]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; metallocarboxypeptidase activity [GO:0004181]	extracellular region [GO:0005576]	GO:0004046; GO:0004181; GO:0005576; GO:0006520; GO:0006629; GO:0006631; GO:0016811; GO:0022904; GO:0097009; GO:1990845
GN019241	GN019241.1	Q12893	48.0	304	359	351	8.28e-91	279	TM115_HUMAN	Transmembrane protein 115 (Placental protein 6) (Protein PL6)	Homo sapiens (Human)	negative regulation of cell population proliferation [GO:0008285]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	identical protein binding [GO:0042802]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]	GO:0000139; GO:0005634; GO:0005794; GO:0006890; GO:0008285; GO:0032580; GO:0042802
GN019243	GN019243.1	Q13825	59.7	268	305	339	9.82e-109	322	AUHM_HUMAN	Methylglutaconyl-CoA hydratase, mitochondrial (3-MG-CoA hydratase) (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding protein/enoyl-CoA hydratase) (Itaconyl-CoA hydratase) (EC 4.2.1.56)	Homo sapiens (Human)	fatty acid beta-oxidation [GO:0006635]; L-leucine catabolic process [GO:0006552]; toxic metabolite repair [GO:0110052]	enoyl-CoA hydratase activity [GO:0004300]; itaconyl-CoA hydratase activity [GO:0050011]; methylglutaconyl-CoA hydratase activity [GO:0004490]; mRNA 3'-UTR binding [GO:0003730]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003730; GO:0004300; GO:0004490; GO:0005739; GO:0005759; GO:0006552; GO:0006635; GO:0050011; GO:0110052
GN019245	GN019245.1	Q7A551	31.9	160	159	166	6.96e-12	63.2	Y1532_STAAN	Putative universal stress protein SA1532	Staphylococcus aureus (strain N315)			cytoplasm [GO:0005737]	GO:0005737
GN019247	GN019247.1	Q3TA59	35.5	234	582	269	1.31e-27	115	JMJD8_MOUSE	JmjC domain-containing protein 8 (Jumonji domain-containing protein 8)	Mus musculus (Mouse)	cellular respiration [GO:0045333]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of glycolytic process [GO:0006110]; regulation of pyruvate kinase activity [GO:1903302]; sprouting angiogenesis [GO:0002040]		cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; nucleus [GO:0005634]	GO:0002040; GO:0005634; GO:0005737; GO:0005783; GO:0005788; GO:0006110; GO:0043123; GO:0045333; GO:1903302; GO:1903672
GN019249	GN019249.1	P35408	25.2	330	309	488	2.29e-15	79.7	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of stress fiber assembly [GO:0051492]; response to mechanical stimulus [GO:0009612]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0009612; GO:0016020; GO:0033624; GO:0034695; GO:0042093; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070371; GO:0071260; GO:0071380; GO:2000420
GN019255	GN019255.1	Q14135	29.2	243	424	290	6.04e-09	60.5	VGLL4_HUMAN	Transcription cofactor vestigial-like protein 4 (Vgl-4)	Homo sapiens (Human)	negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of hippo signaling [GO:0035331]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein catabolic process [GO:0045732]	transcription coactivator binding [GO:0001223]	nucleus [GO:0005634]	GO:0001223; GO:0005634; GO:0030178; GO:0030308; GO:0035331; GO:0045732; GO:0045892; GO:0060044
GN019256	GN019256.1	Q53HV7	48.1	241	632	270	3.38e-77	249	SMUG1_HUMAN	Single-strand selective monofunctional uracil DNA glycosylase (EC 3.2.2.-)	Homo sapiens (Human)	base-excision repair [GO:0006284]; depyrimidination [GO:0045008]	DNA N-glycosylase activity [GO:0019104]; identical protein binding [GO:0042802]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]; single-strand selective uracil DNA N-glycosylase activity [GO:0017065]; uracil DNA N-glycosylase activity [GO:0004844]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0000703; GO:0001650; GO:0004844; GO:0005654; GO:0005730; GO:0006284; GO:0017065; GO:0019104; GO:0042802; GO:0045008
GN019257	GN019257.1	F1QCP6	45.5	242	264	262	2.62e-77	238	TAZ_DANRE	Tafazzin (Taz) (EC 2.3.1.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	cardiolipin acyl-chain remodeling [GO:0035965]; heart development [GO:0007507]; heart looping [GO:0001947]; inner mitochondrial membrane organization [GO:0007007]; positive regulation of heart contraction [GO:0045823]	1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]	mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0001947; GO:0005739; GO:0005741; GO:0005743; GO:0007007; GO:0007507; GO:0031966; GO:0035965; GO:0045823; GO:0047184
GN019259	GN019259.1	Q96MG7	43.1	211	270	304	2.49e-46	160	NSE3_HUMAN	Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2)	Homo sapiens (Human)	cellular response to hydroxyurea [GO:0072711]; cellular response to radiation [GO:0071478]; cellular response to UV [GO:0034644]; chromatin looping [GO:0140588]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein ubiquitination [GO:0031398]; protein sumoylation [GO:0016925]; regulation of telomere maintenance [GO:0032204]	protein dimerization activity [GO:0046983]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]	GO:0000122; GO:0000724; GO:0000781; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0016925; GO:0030915; GO:0031398; GO:0032204; GO:0034644; GO:0046983; GO:0071478; GO:0072711; GO:0140588
GN019261	GN019261.1	Q5XPI4	38.4	1277	1200	1314	6.86e-301	882	RN123_HUMAN	E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123)	Homo sapiens (Human)	modification-dependent protein catabolic process [GO:0019941]; protein maturation [GO:0051604]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000209; GO:0005737; GO:0005829; GO:0006511; GO:0019941; GO:0051604; GO:0051726; GO:0061630
GN019262	GN019262.1	Q9D4D4	65.1	613	626	627	5.16e-294	816	TKTL2_MOUSE	Transketolase-like protein 2 (EC 2.2.1.1)	Mus musculus (Mouse)	pentose-phosphate shunt, non-oxidative branch [GO:0009052]	thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004802; GO:0005737; GO:0005829; GO:0009052; GO:0030976
GN019263	GN019263.1	A7T0W1	50.5	103	113	159	1.49e-28	104	UXT_NEMVE	Protein UXT homolog	Nematostella vectensis (Starlet sea anemone)	negative regulation of transcription by RNA polymerase II [GO:0000122]	transcription corepressor activity [GO:0003714]	chromatin [GO:0000785]	GO:0000122; GO:0000785; GO:0003714
GN019264	GN019264.1	P42574	27.5	222	415	277	3.60e-16	81.6	CASP3_HUMAN	Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]	Homo sapiens (Human)	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; axonal fasciculation [GO:0007413]; cellular response to staurosporine [GO:0072734]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; glial cell apoptotic process [GO:0034349]; hippocampus development [GO:0021766]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to osmotic stress [GO:0008627]; keratinocyte differentiation [GO:0030216]; learning or memory [GO:0007611]; leukocyte apoptotic process [GO:0071887]; luteolysis [GO:0001554]; negative regulation of cytokine production [GO:0001818]; neuron differentiation [GO:0030182]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet formation [GO:0030220]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein catabolic process [GO:0030163]; protein maturation [GO:0051604]; protein processing [GO:0016485]; proteolysis [GO:0006508]; pyroptotic inflammatory response [GO:0070269]; regulation of macroautophagy [GO:0016241]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647]; regulation of synaptic vesicle cycle [GO:0098693]; response to amino acid [GO:0043200]; response to anesthetic [GO:0072347]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to insulin-like growth factor stimulus [GO:1990418]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to tumor necrosis factor [GO:0034612]; response to X-ray [GO:0010165]; response to xenobiotic stimulus [GO:0009410]; striated muscle cell differentiation [GO:0051146]; swimming behavior [GO:0036269]; synapse pruning [GO:0098883]	aspartic-type endopeptidase activity [GO:0004190]; cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; cysteine-type endopeptidase activity [GO:0004197]; death receptor binding [GO:0005123]; enzyme activator activity [GO:0008047]; peptidase activity [GO:0008233]; phospholipase A2 activator activity [GO:0016005]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	GO:0001554; GO:0001666; GO:0001818; GO:0002020; GO:0004190; GO:0004197; GO:0004861; GO:0005123; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007413; GO:0007611; GO:0008047; GO:0008233; GO:0008627; GO:0009410; GO:0009749; GO:0010165; GO:0014069; GO:0016005; GO:0016241; GO:0016485; GO:0021766; GO:0030163; GO:0030182; GO:0030216; GO:0030218; GO:0030220; GO:0031264; GO:0031647; GO:0032025; GO:0032355; GO:0032496; GO:0032880; GO:0034349; GO:0034612; GO:0035094; GO:0036269; GO:0042542; GO:0043025; GO:0043200; GO:0043525; GO:0044877; GO:0045471; GO:0048011; GO:0051146; GO:0051384; GO:0051604; GO:0070269; GO:0071887; GO:0072347; GO:0072734; GO:0097190; GO:0097193; GO:0097194; GO:0098693; GO:0098883; GO:0098978; GO:0140639; GO:1902004; GO:1990418
GN019265	GN019265.1	Q7SXN5	70.1	693	688	691	0.0	924	DNM1L_DANRE	Dynamin-1-like protein (EC 3.6.5.5)	Danio rerio (Zebrafish) (Brachydanio rerio)	intracellular distribution of mitochondria [GO:0048312]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; peroxisome fission [GO:0016559]; protein complex oligomerization [GO:0051259]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; protein homodimerization activity [GO:0042803]	clathrin-coated pit [GO:0005905]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; peroxisome [GO:0005777]; synaptic vesicle membrane [GO:0030672]	GO:0000266; GO:0003924; GO:0005525; GO:0005739; GO:0005741; GO:0005777; GO:0005794; GO:0005829; GO:0005905; GO:0008017; GO:0012505; GO:0016559; GO:0030672; GO:0042803; GO:0043653; GO:0048312; GO:0051259
GN019266	GN019266.1	Q9Z2I8	62.5	272	308	433	7.43e-111	331	SUCB2_MOUSE	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Itaconyl--CoA ligase [GDP-forming] subunit beta) (EC 6.2.1.-) (Malyl--CoA ligase [GDP-forming] subunit beta) (EC 6.2.1.-) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG)	Mus musculus (Mouse)	succinate metabolic process [GO:0006105]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099]	ATP binding [GO:0005524]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; protein-containing complex binding [GO:0044877]; succinate-CoA ligase (GDP-forming) activity [GO:0004776]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; succinate-CoA ligase complex [GO:0042709]; succinate-CoA ligase complex (GDP-forming) [GO:0045244]	GO:0000287; GO:0004776; GO:0004777; GO:0005524; GO:0005525; GO:0005739; GO:0005759; GO:0005886; GO:0006099; GO:0006104; GO:0006105; GO:0019003; GO:0032991; GO:0042709; GO:0044877; GO:0045244
GN019267	GN019267.1	E7EXX2	58.6	464	532	544	8.09e-177	512	S41A1_DANRE	Solute carrier family 41 member 1	Danio rerio (Zebrafish) (Brachydanio rerio)	chordate embryonic development [GO:0043009]; magnesium ion homeostasis [GO:0010960]; pronephros development [GO:0048793]	magnesium:sodium antiporter activity [GO:0061768]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005886; GO:0010960; GO:0016323; GO:0043009; GO:0048793; GO:0061768
GN019269	GN019269.1	Q96M94	27.0	564	856	604	1.07e-54	203	KLH15_HUMAN	Kelch-like protein 15	Homo sapiens (Human)	negative regulation of double-strand break repair via homologous recombination [GO:2000042]; nuclear protein quality control by the ubiquitin-proteasome system [GO:0071630]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; nucleus [GO:0005634]	GO:0005634; GO:0006511; GO:0016567; GO:0031463; GO:0043161; GO:0071630; GO:1990756; GO:2000042
GN019270	GN019270.1	Q63HM9	40.5	299	310	321	5.60e-79	246	PLCX3_HUMAN	PI-PLC X domain-containing protein 3	Homo sapiens (Human)	lipid metabolic process [GO:0006629]	phosphoric diester hydrolase activity [GO:0008081]	cytoplasm [GO:0005737]; synapse [GO:0045202]	GO:0005737; GO:0006629; GO:0008081; GO:0045202
GN019273	GN019273.1	Q53G44	38.4	250	312	452	7.32e-48	169	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN019274	GN019274.1	Q8BLA8	29.1	237	759	1125	3.89e-10	67.4	TRPA1_MOUSE	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Wasabi receptor)	Mus musculus (Mouse)	calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to caffeine [GO:0071313]; cellular response to carbon dioxide [GO:0071244]; cellular response to cold [GO:0070417]; cellular response to food [GO:0071240]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to toxic substance [GO:0097237]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of monoatomic anion transport [GO:1903793]; protein homotetramerization [GO:0051289]; regulation of blood circulation [GO:1903522]; regulation of neuronal action potential [GO:0098908]; response to cold [GO:0009409]; response to hydrogen peroxide [GO:0042542]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]; ureteric peristalsis [GO:0072105]; urinary bladder smooth muscle contraction [GO:0014832]; vasodilation [GO:0042311]	calcium channel activity [GO:0005262]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; monoatomic ion channel activity [GO:0005216]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]; temperature-gated cation channel activity [GO:0097604]; voltage-gated calcium channel activity [GO:0005245]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; membrane [GO:0016020]; plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]	GO:0005216; GO:0005245; GO:0005262; GO:0005886; GO:0006816; GO:0006874; GO:0007166; GO:0009409; GO:0009410; GO:0014832; GO:0015267; GO:0015278; GO:0016020; GO:0016324; GO:0019233; GO:0030424; GO:0032421; GO:0034605; GO:0035774; GO:0042311; GO:0042542; GO:0042802; GO:0048265; GO:0050955; GO:0050966; GO:0050968; GO:0050974; GO:0051289; GO:0070301; GO:0070417; GO:0070588; GO:0071240; GO:0071244; GO:0071313; GO:0072105; GO:0097237; GO:0097553; GO:0097604; GO:0098908; GO:1903522; GO:1903793; GO:1990760
GN019278	GN019278.1	Q96QE2	47.6	395	399	648	2.47e-113	348	MYCT_HUMAN	Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13)	Homo sapiens (Human)	myo-inositol transport [GO:0015798]; positive regulation of amyloid-beta formation [GO:1902004]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]	ATPase binding [GO:0051117]; myo-inositol transmembrane transporter activity [GO:0005365]; myo-inositol:proton symporter activity [GO:0005366]; protease binding [GO:0002020]	apical plasma membrane [GO:0016324]; astrocyte end-foot [GO:0097450]; cell body [GO:0044297]; cell periphery [GO:0071944]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]	GO:0002020; GO:0005365; GO:0005366; GO:0005737; GO:0005794; GO:0005886; GO:0015798; GO:0016020; GO:0016324; GO:0030426; GO:0031090; GO:0042995; GO:0044297; GO:0051117; GO:0055085; GO:0071944; GO:0097450; GO:0150104; GO:1902004
GN019279	GN019279.1	Q96KE9	33.7	445	462	538	1.05e-72	241	BTBD6_HUMAN	BTB/POZ domain-containing protein 6 (Lens BTB domain protein)	Homo sapiens (Human)	neurogenesis [GO:0022008]		cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0022008
GN019280	GN019280.1	G3H0N9	36.6	287	266	222	4.39e-34	125	DNJB9_CRIGR	DnaJ homolog subfamily B member 9 (Endoplasmic reticulum DNA J domain-containing protein 4) (ER-resident protein ERdj4) (ERdj4)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	B cell differentiation [GO:0030183]; ERAD pathway [GO:0036503]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; positive regulation of immunoglobulin production [GO:0002639]; response to endoplasmic reticulum stress [GO:0034976]	Hsp70 protein binding [GO:0030544]; misfolded protein binding [GO:0051787]; protein-folding chaperone binding [GO:0051087]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	GO:0002639; GO:0005783; GO:0005788; GO:0030183; GO:0030544; GO:0034976; GO:0036503; GO:0051087; GO:0051787; GO:1903895
GN019284	GN019284.1	Q0P4P2	50.0	228	249	457	3.53e-74	235	FBCD1_XENTR	Fibrinogen C domain-containing protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			extracellular matrix [GO:0031012]; membrane [GO:0016020]	GO:0016020; GO:0031012
GN019286	GN019286.1	Q5XTS1	46.5	187	203	786	7.09e-57	194	PLPL8_RABIT	Calcium-independent phospholipase A2-gamma (EC 3.1.1.-) (EC 3.1.1.5) (Group VIB calcium-independent phospholipase A2) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (Patatin-like phospholipase domain-containing protein 8)	Oryctolagus cuniculus (Rabbit)	arachidonate metabolic process [GO:0019369]; cardiolipin metabolic process [GO:0032048]; lipid homeostasis [GO:0055088]; triglyceride homeostasis [GO:0070328]	A2-type glycerophospholipase activity [GO:0004623]; glycerophospholipid phospholipase A1 activity [GO:0008970]; phosphatidylcholine lysophospholipase A1 activity [GO:0004622]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0004622; GO:0004623; GO:0005739; GO:0005777; GO:0005778; GO:0005789; GO:0008970; GO:0016020; GO:0019369; GO:0031966; GO:0032048; GO:0055088; GO:0070328
GN019287	GN019287.1	Q5ZK36	47.2	422	409	417	7.23e-94	291	ING3_CHICK	Inhibitor of growth protein 3	Gallus gallus (Chicken)	chromatin remodeling [GO:0006338]		NuA4 histone acetyltransferase complex [GO:0035267]; Swr1 complex [GO:0000812]	GO:0000812; GO:0006338; GO:0035267
GN019288	GN019288.1	Q6GMG6	42.0	441	452	452	1.18e-98	306	S5A3B_DANRE	Solute carrier family 52, riboflavin transporter, member 3-B (Riboflavin transporter 2-B) (RFT2-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	riboflavin transport [GO:0032218]	riboflavin transmembrane transporter activity [GO:0032217]	plasma membrane [GO:0005886]	GO:0005886; GO:0032217; GO:0032218
GN019289	GN019289.1	Q9LZF7	36.6	123	911	356	2.94e-13	75.9	OTU10_ARATH	OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 10 (OTU domain-containing protein 10) (EC 3.4.19.12) (Deubiquitinating enzyme OTU10)	Arabidopsis thaliana (Mouse-ear cress)		cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004843; GO:0005737; GO:0005886
GN019290	GN019290.1	Q9LZF7	35.7	126	1067	356	1.15e-12	74.3	OTU10_ARATH	OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 10 (OTU domain-containing protein 10) (EC 3.4.19.12) (Deubiquitinating enzyme OTU10)	Arabidopsis thaliana (Mouse-ear cress)		cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004843; GO:0005737; GO:0005886
GN019291	GN019291.1	Q91VU7	41.0	586	692	660	6.22e-149	451	PUS7_MOUSE	Pseudouridylate synthase 7 homolog (EC 5.4.99.-)	Mus musculus (Mouse)	mRNA pseudouridine synthesis [GO:1990481]; negative regulation of translation [GO:0017148]; pseudouridine synthesis [GO:0001522]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of mesoderm development [GO:2000380]; tRNA pseudouridine synthesis [GO:0031119]	enzyme binding [GO:0019899]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029]; tRNA pseudouridine(13) synthase activity [GO:0160150]	nucleus [GO:0005634]	GO:0001522; GO:0003723; GO:0005634; GO:0009982; GO:0017148; GO:0019899; GO:0031119; GO:0106029; GO:0160150; GO:1902036; GO:1990481; GO:2000380
GN019292	GN019292.1	Q7Z6Z7	39.8	1180	1142	4374	4.18e-140	473	HUWE1_HUMAN	E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)	Homo sapiens (Human)	base-excision repair [GO:0006284]; circadian regulation of gene expression [GO:0032922]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein localization to mitochondrion [GO:1903749]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of type 2 mitophagy [GO:1905091]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein branched polyubiquitination [GO:0141198]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	DNA binding [GO:0003677]; histone ubiquitin ligase activity [GO:0140852]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]	GO:0000139; GO:0000209; GO:0003677; GO:0003723; GO:0004842; GO:0005576; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0006284; GO:0006511; GO:0006513; GO:0007030; GO:0010637; GO:0016020; GO:0031398; GO:0031965; GO:0032922; GO:0034450; GO:0034774; GO:0035359; GO:0043123; GO:0043161; GO:0061025; GO:0061630; GO:0070062; GO:0070936; GO:0140852; GO:0141198; GO:1903749; GO:1904813; GO:1905091
GN019293	GN019293.1	A7RX26	57.8	294	319	429	6.75e-119	352	HUTI_NEMVE	Probable imidazolonepropionase (EC 3.5.2.7) (Amidohydrolase domain-containing protein 1 homolog)	Nematostella vectensis (Starlet sea anemone)	L-histidine catabolic process [GO:0006548]	imidazolonepropionase activity [GO:0050480]	cytoplasm [GO:0005737]	GO:0005737; GO:0006548; GO:0050480
GN019296	GN019296.1	A0A6I8TCE0	36.7	1199	1401	1309	4.66e-230	705	PTP1_AEDAE	Putative receptor-type tyrosine-protein phosphatase mosPTP-1 (mosPTP-1) (EC 3.1.3.48)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	anatomical structure morphogenesis [GO:0009653]; neuron development [GO:0048666]	protein tyrosine phosphatase activity [GO:0004725]	plasma membrane [GO:0005886]	GO:0004725; GO:0005886; GO:0009653; GO:0048666
GN019297	GN019297.1	Q6NRT3	66.5	507	523	513	3.86e-180	519	SMU1_XENLA	WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog)	Xenopus laevis (African clawed frog)	mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]		cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]	GO:0000381; GO:0000398; GO:0005634; GO:0005737; GO:0016607; GO:0071005; GO:0071011
GN019298	GN019298.1	Q7PCJ9	30.0	140	139	170	4.50e-20	84.0	SAT2_PIG	Thialysine N-epsilon-acetyltransferase (EC 2.3.1.-) (Diamine acetyltransferase 2) (EC 2.3.1.57) (Spermidine/spermine N(1)-acetyltransferase 2) (SSAT-2)	Sus scrofa (Pig)	polyamine metabolic process [GO:0006595]	diamine N-acetyltransferase activity [GO:0004145]; N-acetyltransferase activity [GO:0008080]	cytoplasm [GO:0005737]	GO:0004145; GO:0005737; GO:0006595; GO:0008080
GN019299	GN019299.1	Q8R066	28.7	303	448	326	2.70e-15	80.1	C1QT4_MOUSE	Complement C1q tumor necrosis factor-related protein 4 (C1q/TNF-related protein 4)	Mus musculus (Mouse)	cell surface receptor signaling pathway via STAT [GO:0097696]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; macrophage activation [GO:0042116]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of tumor necrosis factor production [GO:0032760]; protein import [GO:0017038]; protein phosphorylation [GO:0006468]; reduction of food intake in response to dietary excess [GO:0002023]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; toll-like receptor 4 signaling pathway [GO:0034142]		extracellular region [GO:0005576]	GO:0002023; GO:0005576; GO:0006468; GO:0006954; GO:0009611; GO:0010467; GO:0017038; GO:0032496; GO:0032755; GO:0032760; GO:0034142; GO:0042116; GO:0070105; GO:0097696; GO:1901224
GN019302	GN019302.1	Q80Y56	42.1	504	494	783	4.27e-108	342	RBNS5_MOUSE	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20)	Mus musculus (Mouse)	early endosome to Golgi transport [GO:0034498]; Golgi to lysosome transport [GO:0090160]; regulation of Golgi organization [GO:1903358]	metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]	GO:0005769; GO:0005829; GO:0005886; GO:0031267; GO:0031901; GO:0032266; GO:0034498; GO:0046872; GO:0090160; GO:1903358
GN019305	GN019305.1	Q9I931	33.6	122	258	178	1.45e-10	62.0	FUCL1_ANGJA	Fucolectin-1	Anguilla japonica (Japanese eel)	regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]	calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; fucose binding [GO:0042806]	extracellular region [GO:0005576]	GO:0001868; GO:0005509; GO:0005576; GO:0010185; GO:0030246; GO:0042806; GO:0045088
GN019307	GN019307.1	Q3UF25	45.9	246	290	288	6.42e-70	221	STIMA_MOUSE	Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110)	Mus musculus (Mouse)	activation of store-operated calcium channel activity [GO:0032237]; store-operated calcium entry [GO:0002115]	calcium channel regulator activity [GO:0005246]	cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-plasma membrane contact site [GO:0140268]; membrane [GO:0016020]	GO:0002115; GO:0005246; GO:0005789; GO:0016020; GO:0032237; GO:0032541; GO:0140268
GN019308	GN019308.1	Q5VUG0	43.9	889	1224	894	1.27e-224	672	SMBT2_HUMAN	Scm-like with four MBT domains protein 2 (Scm-like with 4 MBT domains protein 2)	Homo sapiens (Human)	negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of gene expression [GO:0010629]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; transcription corepressor activity [GO:0003714]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003682; GO:0003714; GO:0005634; GO:0005654; GO:0010629; GO:0016607; GO:0042393; GO:0045892
GN019309	GN019309.1	Q6P2Y3	47.9	361	360	620	1.44e-68	229	DNJC2_XENTR	DnaJ homolog subfamily C member 2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	'de novo' cotranslational protein folding [GO:0051083]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of translational fidelity [GO:0006450]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; Hsp70 protein binding [GO:0030544]; ribosome binding [GO:0043022]; ubiquitin-modified histone reader activity [GO:0061649]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003682; GO:0005634; GO:0005829; GO:0006450; GO:0030544; GO:0042393; GO:0043022; GO:0045893; GO:0051083; GO:0061649
GN019310	GN019310.1	Q28C33	50.2	613	1008	907	5.47e-177	542	TBC30_XENTR	TBC1 domain family member 30	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			endoplasmic reticulum [GO:0005783]	GO:0005783
GN019311	GN019311.1	Q8BX57	57.3	443	574	582	3.77e-172	503	PXK_MOUSE	PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)	Mus musculus (Mouse)	inflammatory response [GO:0006954]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of ATP-dependent activity [GO:0032780]; negative regulation of monoatomic ion transport [GO:0043271]	actin binding [GO:0003779]; ATP binding [GO:0005524]; phosphatidylinositol binding [GO:0035091]; protein kinase activity [GO:0004672]	centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GO:0003779; GO:0004672; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006954; GO:0032780; GO:0032991; GO:0034451; GO:0035091; GO:0043271; GO:0050804
GN019312	GN019312.1	Q5ZIH2	55.0	407	520	549	2.03e-154	454	MON1A_CHICK	Vacuolar fusion protein MON1 homolog A	Gallus gallus (Chicken)	protein secretion [GO:0009306]; protein targeting to vacuole [GO:0006623]; vesicle-mediated transport [GO:0016192]	guanyl-nucleotide exchange factor activity [GO:0005085]	Mon1-Ccz1 complex [GO:0035658]	GO:0005085; GO:0006623; GO:0009306; GO:0016192; GO:0035658
GN019314	GN019314.1	Q6ZVT6	37.3	126	462	689	9.84e-12	70.9	CF20D_HUMAN	Protein CFAP20DC (Uncharacterized protein C3orf67)	Homo sapiens (Human)				
GN019316	GN019316.1	Q86Z23	37.0	146	291	238	6.40e-12	67.4	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN019317	GN019317.1	Q9Y5R4	38.0	142	145	338	8.01e-25	100	HEMK1_HUMAN	MTRF1L release factor glutamine methyltransferase (EC 2.1.1.297) (HemK methyltransferase family member 1) (M.HsaHemKP)	Homo sapiens (Human)	translational termination [GO:0006415]	DNA binding [GO:0003677]; peptide chain release factor N(5)-glutamine methyltransferase activity [GO:0102559]; protein-glutamine N-methyltransferase activity [GO:0036009]	mitochondrion [GO:0005739]	GO:0003677; GO:0005739; GO:0006415; GO:0036009; GO:0102559
GN019318	GN019318.1	Q8R0F3	63.6	283	378	372	1.59e-139	404	SUMF1_MOUSE	Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1)	Mus musculus (Mouse)	post-translational protein modification [GO:0043687]; protein oxidation [GO:0018158]	cupric ion binding [GO:1903135]; formylglycine-generating oxidase activity [GO:0120147]; identical protein binding [GO:0042802]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	GO:0005783; GO:0005788; GO:0018158; GO:0042802; GO:0043687; GO:0120147; GO:1903135
GN019320	GN019320.1	Q96I25	53.1	435	406	401	3.23e-90	281	SPF45_HUMAN	Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17)	Homo sapiens (Human)	alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA cis splicing, via spliceosome [GO:0045292]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	GO:0000380; GO:0003723; GO:0005654; GO:0032991; GO:0045292
GN019321	GN019321.1	Q6GLL2	34.3	181	189	337	9.79e-31	117	ABH6A_XENLA	Monoacylglycerol lipase abhd6-A (EC 3.1.1.23) (Abhydrolase domain-containing protein 6-A)	Xenopus laevis (African clawed frog)	acylglycerol catabolic process [GO:0046464]; lysobisphosphatidic acid metabolic process [GO:2001311]; monoacylglycerol catabolic process [GO:0052651]	monoacylglycerol lipase activity [GO:0047372]	AMPA glutamate receptor complex [GO:0032281]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]	GO:0005765; GO:0016020; GO:0031902; GO:0031966; GO:0032281; GO:0046464; GO:0047372; GO:0052651; GO:2001311
GN019322	GN019322.1	Q9MYW6	41.3	1234	1222	1331	2.43e-312	913	XDH_FELCA	Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)]	Felis catus (Cat) (Felis silvestris catus)	AMP catabolic process [GO:0006196]; deoxyinosine catabolic process [GO:0006149]; hypoxanthine catabolic process [GO:0009114]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; xanthine catabolic process [GO:0009115]	2 iron, 2 sulfur cluster binding [GO:0051537]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; hypoxanthine dehydrogenase activity [GO:0070674]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; xanthine dehydrogenase activity [GO:0004854]; xanthine oxidase activity [GO:0004855]	cytosol [GO:0005829]; extracellular region [GO:0005576]; peroxisome [GO:0005777]	GO:0004854; GO:0004855; GO:0005506; GO:0005576; GO:0005777; GO:0005829; GO:0006148; GO:0006149; GO:0006196; GO:0006204; GO:0009114; GO:0009115; GO:0043546; GO:0050660; GO:0051537; GO:0070674; GO:0071949
GN019323	GN019323.1	Q95LL8	20.2	699	749	569	2.24e-15	83.6	EFC12_MACFA	EF-hand calcium-binding domain-containing protein 12	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)		calcium ion binding [GO:0005509]		GO:0005509
GN019325	GN019325.1	Q08BL7	41.4	517	585	502	3.03e-122	373	GLCTK_DANRE	Glycerate kinase (EC 2.7.1.31)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein phosphorylation [GO:0006468]	glycerate kinase activity [GO:0008887]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]	GO:0005737; GO:0005759; GO:0006468; GO:0008887
GN019326	GN019326.1	P09960	56.1	608	613	611	9.60e-251	706	LKHA4_HUMAN	Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4)	Homo sapiens (Human)	leukotriene biosynthetic process [GO:0019370]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; response to peptide hormone [GO:0043434]; response to zinc ion [GO:0010043]; type I pneumocyte differentiation [GO:0060509]	aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; leukotriene-A4 hydrolase activity [GO:0004463]; metalloaminopeptidase activity [GO:0070006]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]; tripeptide aminopeptidase activity [GO:0045148]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724]	GO:0003723; GO:0004177; GO:0004301; GO:0004463; GO:0005576; GO:0005737; GO:0005829; GO:0006508; GO:0008233; GO:0008270; GO:0010043; GO:0019370; GO:0043171; GO:0043434; GO:0045148; GO:0060509; GO:0070006; GO:0070062; GO:1904724; GO:1904813
GN019327	GN019327.1	Q9CPW0	32.1	196	545	1332	4.24e-25	114	CNTP2_MOUSE	Contactin-associated protein-like 2 (Cell recognition molecule Caspr2)	Mus musculus (Mouse)	action potential initiation [GO:0099610]; adult behavior [GO:0030534]; associative learning [GO:0008306]; axonogenesis [GO:0007409]; behavioral response to pain [GO:0048266]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; central nervous system myelination [GO:0022010]; cerebellar Purkinje cell layer morphogenesis [GO:0021692]; cerebellum development [GO:0021549]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle [GO:0042745]; clustering of voltage-gated potassium channels [GO:0045163]; dendrite arborization [GO:0140059]; dendritic spine development [GO:0060996]; dendritic spine maintenance [GO:0097062]; dendritic spine organization [GO:0097061]; embryonic brain development [GO:1990403]; ERK1 and ERK2 cascade [GO:0070371]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; excitatory synapse assembly [GO:1904861]; fat cell differentiation [GO:0045444]; gene expression [GO:0010467]; glial cell proliferation [GO:0014009]; glutamatergic neuron differentiation [GO:1905962]; grooming behavior [GO:0007625]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; inhibitory chemical synaptic transmission [GO:0098977]; inhibitory synapse assembly [GO:1904862]; intracellular protein localization [GO:0008104]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; limbic system development [GO:0021761]; locomotor rhythm [GO:0045475]; locomotory behavior [GO:0007626]; maintenance of synapse structure [GO:0099558]; mitochondrion organization [GO:0007005]; motor behavior [GO:0061744]; multicellular organism growth [GO:0035264]; myelination [GO:0042552]; negative regulation of neuronal action potential [GO:1904456]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; nervous system development [GO:0007399]; neural precursor cell proliferation [GO:0061351]; neuromuscular junction development, skeletal muscle fiber [GO:0098529]; neuromuscular process [GO:0050905]; neuromuscular process controlling posture [GO:0050884]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; neuron recognition [GO:0008038]; neuronal action potential [GO:0019228]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of neuronal action potential [GO:1904457]; postsynaptic density organization [GO:0097106]; prepulse inhibition [GO:0060134]; protein localization to juxtaparanode region of axon [GO:0071205]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to dietary excess [GO:0002021]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to interleukin-17 [GO:0097396]; response to light intensity [GO:0009642]; response to mechanical stimulus [GO:0009612]; response to metformin [GO:1901558]; response to odorant [GO:1990834]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; rhythmic behavior [GO:0007622]; signal transduction [GO:0007165]; social behavior [GO:0035176]; startle response [GO:0001964]; TOR signaling [GO:0031929]; transmission of nerve impulse [GO:0019226]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]; walking behavior [GO:0090659]	enzyme binding [GO:0019899]; PDZ domain binding [GO:0030165]; protease binding [GO:0002020]; transmembrane transporter binding [GO:0044325]	axolemma [GO:0030673]; axon [GO:0030424]; axon initial segment [GO:0043194]; cell surface [GO:0009986]; cerebellar granule cell to Purkinje cell synapse [GO:0150048]; dendrite [GO:0030425]; early endosome [GO:0005769]; excitatory synapse [GO:0060076]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynapse [GO:0098794]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; voltage-gated potassium channel complex [GO:0008076]	GO:0000902; GO:0001701; GO:0001964; GO:0002020; GO:0002021; GO:0005769; GO:0005794; GO:0005886; GO:0006954; GO:0007005; GO:0007155; GO:0007165; GO:0007268; GO:0007399; GO:0007409; GO:0007612; GO:0007622; GO:0007625; GO:0007626; GO:0008038; GO:0008076; GO:0008104; GO:0008283; GO:0008306; GO:0009408; GO:0009410; GO:0009612; GO:0009642; GO:0009725; GO:0009986; GO:0010467; GO:0014009; GO:0016020; GO:0019226; GO:0019228; GO:0019899; GO:0021549; GO:0021692; GO:0021761; GO:0022010; GO:0030165; GO:0030424; GO:0030425; GO:0030534; GO:0030673; GO:0031175; GO:0031929; GO:0032229; GO:0033010; GO:0033270; GO:0035176; GO:0035264; GO:0035556; GO:0042297; GO:0042552; GO:0042734; GO:0042745; GO:0043005; GO:0043025; GO:0043194; GO:0044224; GO:0044309; GO:0044325; GO:0044853; GO:0045163; GO:0045202; GO:0045444; GO:0045475; GO:0048265; GO:0048266; GO:0048787; GO:0048812; GO:0050884; GO:0050905; GO:0051898; GO:0060076; GO:0060079; GO:0060134; GO:0060996; GO:0061351; GO:0061744; GO:0070371; GO:0071205; GO:0071625; GO:0090659; GO:0097060; GO:0097061; GO:0097062; GO:0097106; GO:0097396; GO:0098529; GO:0098793; GO:0098794; GO:0098976; GO:0098977; GO:0098978; GO:0098982; GO:0099072; GO:0099558; GO:0099610; GO:0140059; GO:0150048; GO:1901558; GO:1903598; GO:1904456; GO:1904457; GO:1904861; GO:1904862; GO:1905962; GO:1990403; GO:1990834
GN019329	GN019329.1	Q96RW7	35.0	120	313	5635	1.86e-14	77.8	HMCN1_HUMAN	Hemicentin-1 (Fibulin-6) (FIBL-6)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion mediator activity [GO:0098631]; extracellular matrix structural constituent [GO:0005201]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; muscle tendon junction [GO:0005927]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005886; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0030036; GO:0031012; GO:0032154; GO:0070062; GO:0070161; GO:0071711; GO:0098631; GO:0140144
GN019330	GN019330.1	Q9VIW7	45.4	502	542	506	2.48e-119	364	RTCB_DROME	RNA-splicing ligase RtcB (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)	Drosophila melanogaster (Fruit fly)	positive regulation of tRNA processing [GO:2000237]; tRNA processing [GO:0008033]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]	RNA ligase (GTP) activity [GO:0170057]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; tRNA-splicing ligase complex [GO:0072669]	GO:0005634; GO:0005737; GO:0006388; GO:0008033; GO:0072669; GO:0170057; GO:2000237
GN019331	GN019331.1	P91685	58.3	427	502	976	2.52e-165	496	GRM_DROME	Metabotropic glutamate receptor (DmGluRA)	Drosophila melanogaster (Fruit fly)	G protein-coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; long-term memory [GO:0007616]; male courtship behavior [GO:0008049]; neuromuscular junction development [GO:0007528]; regulation of synaptic transmission, glutamatergic [GO:0051966]; short-term memory [GO:0007614]; terminal button organization [GO:0072553]	cholesterol binding [GO:0015485]; G protein-coupled receptor activity [GO:0004930]; glutamate binding [GO:0016595]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]	G protein-coupled receptor homodimeric complex [GO:0038038]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]	GO:0001641; GO:0004930; GO:0005886; GO:0007216; GO:0007528; GO:0007612; GO:0007614; GO:0007616; GO:0008049; GO:0008066; GO:0015485; GO:0016020; GO:0016595; GO:0038038; GO:0045121; GO:0051966; GO:0072553
GN019332	GN019332.1	O76924	61.6	487	481	509	1.36e-222	625	ARI2_DROME	Potential E3 ubiquitin-protein ligase ariadne-2 (EC 2.3.2.31) (Protein ariadne-2) (RING-type E3 ubiquitin transferase ariadne-2)	Drosophila melanogaster (Fruit fly)	protein polyubiquitination [GO:0000209]	ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000209; GO:0004842; GO:0005634; GO:0008270; GO:0031624; GO:0061630
GN019333	GN019333.1	Q61704	35.0	900	901	889	4.32e-145	455	ITIH3_MOUSE	Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3)	Mus musculus (Mouse)	hyaluronan metabolic process [GO:0030212]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular matrix [GO:0031012]	GO:0004867; GO:0030212; GO:0031012
GN019335	GN019335.1	Q28HX4	57.0	405	417	411	2.85e-152	440	IFT57_XENTR	Intraflagellar transport protein 57 homolog	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	apoptotic process [GO:0006915]; intraciliary transport [GO:0042073]; non-motile cilium assembly [GO:1905515]; regulation of apoptotic process [GO:0042981]		ciliary basal body [GO:0036064]; cilium [GO:0005929]; Golgi apparatus [GO:0005794]; intraciliary transport particle B [GO:0030992]; microtubule organizing center [GO:0005815]	GO:0005794; GO:0005815; GO:0005929; GO:0006915; GO:0030992; GO:0036064; GO:0042073; GO:0042981; GO:1905515
GN019336	GN019336.1	Q9HCM2	27.2	1300	1243	1894	9.94e-118	407	PLXA4_HUMAN	Plexin-A4	Homo sapiens (Human)	axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; embryonic heart tube development [GO:0035050]; facial nerve structural organization [GO:0021612]; maintenance of synapse structure [GO:0099558]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; regulation of chemotaxis [GO:0050920]; semaphorin-plexin signaling pathway [GO:0071526]; sympathetic neuron axon guidance [GO:0097492]; synapse assembly [GO:0007416]; telencephalon development [GO:0021537]; trigeminal nerve structural organization [GO:0021637]	semaphorin receptor activity [GO:0017154]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	GO:0002116; GO:0005886; GO:0007411; GO:0007416; GO:0008045; GO:0017154; GO:0021537; GO:0021612; GO:0021637; GO:0021785; GO:0030334; GO:0035050; GO:0048841; GO:0050919; GO:0050920; GO:0071526; GO:0097492; GO:0099558; GO:0150053
GN019337	GN019337.1	Q58A42	33.6	672	667	616	3.23e-97	314	DD3_DICDI	Protein DD3-3	Dictyostelium discoideum (Social amoeba)			membrane [GO:0016020]	GO:0016020
GN019338	GN019338.1	Q8NI99	34.3	213	239	470	1.53e-32	126	ANGL6_HUMAN	Angiopoietin-related protein 6 (Angiopoietin-like protein 6) (Angiopoietin-related growth factor) (Angiopoietin-related protein 5)	Homo sapiens (Human)	blood coagulation [GO:0007596]	signaling receptor binding [GO:0005102]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; secretory granule [GO:0030141]	GO:0005102; GO:0007596; GO:0030141; GO:0031012; GO:0070062
GN019341	GN019341.1	Q4JL91	30.9	501	505	483	2.78e-46	171	IPPK_DANRE	Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase)	Danio rerio (Zebrafish) (Brachydanio rerio)	determination of left/right symmetry [GO:0007368]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; melanosome transport [GO:0032402]	ATP binding [GO:0005524]; inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity [GO:0035299]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0005524; GO:0005576; GO:0005634; GO:0005737; GO:0005813; GO:0007368; GO:0032402; GO:0035299; GO:0036064; GO:0060287
GN019342	GN019342.1	O93530	28.5	253	240	1436	4.07e-22	98.2	WRN_XENLA	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Focus-forming activity 1) (FFA-1) (Werner syndrome protein homolog) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Xenopus laevis (African clawed frog)	DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; four-way junction helicase activity [GO:0009378]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000723; GO:0000724; GO:0000781; GO:0003676; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006259; GO:0006260; GO:0008408; GO:0009378; GO:0016887; GO:0030145; GO:0032392; GO:0043138
GN019343	GN019343.1	Q9GLY5	34.0	644	641	903	1.02e-86	293	ITIH3_RABIT	Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3)	Oryctolagus cuniculus (Rabbit)	hyaluronan metabolic process [GO:0030212]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]	GO:0004867; GO:0005576; GO:0030212
GN019344	GN019344.1	O75051	27.8	684	1220	1894	7.72e-61	233	PLXA2_HUMAN	Plexin-A2 (Semaphorin receptor OCT)	Homo sapiens (Human)	animal organ development [GO:0048513]; limb bud formation [GO:0060174]; neural tube development [GO:0021915]; pharyngeal system development [GO:0060037]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; somitogenesis [GO:0001756]; synapse assembly [GO:0007416]	identical protein binding [GO:0042802]; semaphorin receptor activity [GO:0017154]	plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	GO:0001756; GO:0002116; GO:0005886; GO:0007416; GO:0017154; GO:0021915; GO:0030334; GO:0042802; GO:0048513; GO:0060037; GO:0060174; GO:0071526
GN019345	GN019345.1	O44252	23.3	232	261	275	1.45e-10	63.5	ROST_DROME	Protein rolling stone	Drosophila melanogaster (Fruit fly)	myoblast fusion [GO:0007520]		membrane [GO:0016020]	GO:0007520; GO:0016020
GN019347	GN019347.1	P09960	56.1	608	613	611	9.60e-251	706	LKHA4_HUMAN	Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4)	Homo sapiens (Human)	leukotriene biosynthetic process [GO:0019370]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; response to peptide hormone [GO:0043434]; response to zinc ion [GO:0010043]; type I pneumocyte differentiation [GO:0060509]	aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; leukotriene-A4 hydrolase activity [GO:0004463]; metalloaminopeptidase activity [GO:0070006]; peptidase activity [GO:0008233]; RNA binding [GO:0003723]; tripeptide aminopeptidase activity [GO:0045148]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724]	GO:0003723; GO:0004177; GO:0004301; GO:0004463; GO:0005576; GO:0005737; GO:0005829; GO:0006508; GO:0008233; GO:0008270; GO:0010043; GO:0019370; GO:0043171; GO:0043434; GO:0045148; GO:0060509; GO:0070006; GO:0070062; GO:1904724; GO:1904813
GN019348	GN019348.1	Q9CPW0	32.1	196	545	1332	4.24e-25	114	CNTP2_MOUSE	Contactin-associated protein-like 2 (Cell recognition molecule Caspr2)	Mus musculus (Mouse)	action potential initiation [GO:0099610]; adult behavior [GO:0030534]; associative learning [GO:0008306]; axonogenesis [GO:0007409]; behavioral response to pain [GO:0048266]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; central nervous system myelination [GO:0022010]; cerebellar Purkinje cell layer morphogenesis [GO:0021692]; cerebellum development [GO:0021549]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle [GO:0042745]; clustering of voltage-gated potassium channels [GO:0045163]; dendrite arborization [GO:0140059]; dendritic spine development [GO:0060996]; dendritic spine maintenance [GO:0097062]; dendritic spine organization [GO:0097061]; embryonic brain development [GO:1990403]; ERK1 and ERK2 cascade [GO:0070371]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; excitatory synapse assembly [GO:1904861]; fat cell differentiation [GO:0045444]; gene expression [GO:0010467]; glial cell proliferation [GO:0014009]; glutamatergic neuron differentiation [GO:1905962]; grooming behavior [GO:0007625]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; inhibitory chemical synaptic transmission [GO:0098977]; inhibitory synapse assembly [GO:1904862]; intracellular protein localization [GO:0008104]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; limbic system development [GO:0021761]; locomotor rhythm [GO:0045475]; locomotory behavior [GO:0007626]; maintenance of synapse structure [GO:0099558]; mitochondrion organization [GO:0007005]; motor behavior [GO:0061744]; multicellular organism growth [GO:0035264]; myelination [GO:0042552]; negative regulation of neuronal action potential [GO:1904456]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; nervous system development [GO:0007399]; neural precursor cell proliferation [GO:0061351]; neuromuscular junction development, skeletal muscle fiber [GO:0098529]; neuromuscular process [GO:0050905]; neuromuscular process controlling posture [GO:0050884]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; neuron recognition [GO:0008038]; neuronal action potential [GO:0019228]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of neuronal action potential [GO:1904457]; postsynaptic density organization [GO:0097106]; prepulse inhibition [GO:0060134]; protein localization to juxtaparanode region of axon [GO:0071205]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; response to dietary excess [GO:0002021]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to interleukin-17 [GO:0097396]; response to light intensity [GO:0009642]; response to mechanical stimulus [GO:0009612]; response to metformin [GO:1901558]; response to odorant [GO:1990834]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; rhythmic behavior [GO:0007622]; signal transduction [GO:0007165]; social behavior [GO:0035176]; startle response [GO:0001964]; TOR signaling [GO:0031929]; transmission of nerve impulse [GO:0019226]; vocal learning [GO:0042297]; vocalization behavior [GO:0071625]; walking behavior [GO:0090659]	enzyme binding [GO:0019899]; PDZ domain binding [GO:0030165]; protease binding [GO:0002020]; transmembrane transporter binding [GO:0044325]	axolemma [GO:0030673]; axon [GO:0030424]; axon initial segment [GO:0043194]; cell surface [GO:0009986]; cerebellar granule cell to Purkinje cell synapse [GO:0150048]; dendrite [GO:0030425]; early endosome [GO:0005769]; excitatory synapse [GO:0060076]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; paranodal junction [GO:0033010]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynapse [GO:0098794]; presynapse [GO:0098793]; presynaptic active zone membrane [GO:0048787]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; voltage-gated potassium channel complex [GO:0008076]	GO:0000902; GO:0001701; GO:0001964; GO:0002020; GO:0002021; GO:0005769; GO:0005794; GO:0005886; GO:0006954; GO:0007005; GO:0007155; GO:0007165; GO:0007268; GO:0007399; GO:0007409; GO:0007612; GO:0007622; GO:0007625; GO:0007626; GO:0008038; GO:0008076; GO:0008104; GO:0008283; GO:0008306; GO:0009408; GO:0009410; GO:0009612; GO:0009642; GO:0009725; GO:0009986; GO:0010467; GO:0014009; GO:0016020; GO:0019226; GO:0019228; GO:0019899; GO:0021549; GO:0021692; GO:0021761; GO:0022010; GO:0030165; GO:0030424; GO:0030425; GO:0030534; GO:0030673; GO:0031175; GO:0031929; GO:0032229; GO:0033010; GO:0033270; GO:0035176; GO:0035264; GO:0035556; GO:0042297; GO:0042552; GO:0042734; GO:0042745; GO:0043005; GO:0043025; GO:0043194; GO:0044224; GO:0044309; GO:0044325; GO:0044853; GO:0045163; GO:0045202; GO:0045444; GO:0045475; GO:0048265; GO:0048266; GO:0048787; GO:0048812; GO:0050884; GO:0050905; GO:0051898; GO:0060076; GO:0060079; GO:0060134; GO:0060996; GO:0061351; GO:0061744; GO:0070371; GO:0071205; GO:0071625; GO:0090659; GO:0097060; GO:0097061; GO:0097062; GO:0097106; GO:0097396; GO:0098529; GO:0098793; GO:0098794; GO:0098976; GO:0098977; GO:0098978; GO:0098982; GO:0099072; GO:0099558; GO:0099610; GO:0140059; GO:0150048; GO:1901558; GO:1903598; GO:1904456; GO:1904457; GO:1904861; GO:1904862; GO:1905962; GO:1990403; GO:1990834
GN019350	GN019350.1	Q7Z3G6	75.0	264	657	844	1.32e-148	454	PRIC2_HUMAN	Prickle-like protein 2	Homo sapiens (Human)	blastocyst formation [GO:0001825]; protein localization to axon [GO:0099612]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	zinc ion binding [GO:0008270]	axon [GO:0030424]; axon initial segment [GO:0043194]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]	GO:0001825; GO:0005634; GO:0005737; GO:0008270; GO:0014069; GO:0030424; GO:0030425; GO:0043194; GO:0060071; GO:0099612
GN019352	GN019352.1	Q08BL7	41.4	517	585	502	3.03e-122	373	GLCTK_DANRE	Glycerate kinase (EC 2.7.1.31)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein phosphorylation [GO:0006468]	glycerate kinase activity [GO:0008887]	cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]	GO:0005737; GO:0005759; GO:0006468; GO:0008887
GN019353	GN019353.1	Q7SY73	36.7	286	299	337	1.83e-60	198	ABH6B_XENLA	Monoacylglycerol lipase abhd6-B (EC 3.1.1.23) (Abhydrolase domain-containing protein 6-B)	Xenopus laevis (African clawed frog)	acylglycerol catabolic process [GO:0046464]; lysobisphosphatidic acid metabolic process [GO:2001311]; monoacylglycerol catabolic process [GO:0052651]	monoacylglycerol lipase activity [GO:0047372]	AMPA glutamate receptor complex [GO:0032281]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]	GO:0005765; GO:0016020; GO:0031902; GO:0031966; GO:0032281; GO:0046464; GO:0047372; GO:0052651; GO:2001311
GN019354	GN019354.1	Q96I25	54.5	380	395	401	2.18e-78	250	SPF45_HUMAN	Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17)	Homo sapiens (Human)	alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA cis splicing, via spliceosome [GO:0045292]	RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]	GO:0000380; GO:0003723; GO:0005654; GO:0032991; GO:0045292
GN019358	GN019358.1	Q80Y56	42.1	504	494	783	4.27e-108	342	RBNS5_MOUSE	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20)	Mus musculus (Mouse)	early endosome to Golgi transport [GO:0034498]; Golgi to lysosome transport [GO:0090160]; regulation of Golgi organization [GO:1903358]	metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]; small GTPase binding [GO:0031267]	cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; plasma membrane [GO:0005886]	GO:0005769; GO:0005829; GO:0005886; GO:0031267; GO:0031901; GO:0032266; GO:0034498; GO:0046872; GO:0090160; GO:1903358
GN019361	GN019361.1	Q6NRT3	84.6	513	513	513	6.80e-256	711	SMU1_XENLA	WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog)	Xenopus laevis (African clawed frog)	mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]		cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]	GO:0000381; GO:0000398; GO:0005634; GO:0005737; GO:0016607; GO:0071005; GO:0071011
GN019362	GN019362.1	Q7Z6Z7	45.5	2220	2099	4374	0.0	1246	HUWE1_HUMAN	E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)	Homo sapiens (Human)	base-excision repair [GO:0006284]; circadian regulation of gene expression [GO:0032922]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein localization to mitochondrion [GO:1903749]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of type 2 mitophagy [GO:1905091]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein branched polyubiquitination [GO:0141198]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	DNA binding [GO:0003677]; histone ubiquitin ligase activity [GO:0140852]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]	GO:0000139; GO:0000209; GO:0003677; GO:0003723; GO:0004842; GO:0005576; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0006284; GO:0006511; GO:0006513; GO:0007030; GO:0010637; GO:0016020; GO:0031398; GO:0031965; GO:0032922; GO:0034450; GO:0034774; GO:0035359; GO:0043123; GO:0043161; GO:0061025; GO:0061630; GO:0070062; GO:0070936; GO:0140852; GO:0141198; GO:1903749; GO:1904813; GO:1905091
GN019364	GN019364.1	Q9LZF7	37.4	123	1067	356	1.15e-12	74.3	OTU10_ARATH	OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 10 (OTU domain-containing protein 10) (EC 3.4.19.12) (Deubiquitinating enzyme OTU10)	Arabidopsis thaliana (Mouse-ear cress)		cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0004843; GO:0005737; GO:0005886
GN019365	GN019365.1	Q7TMY8	61.6	1299	1298	4377	0.0	1464	HUWE1_MOUSE	E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (E3Histone) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)	Mus musculus (Mouse)	base-excision repair [GO:0006284]; canonical NF-kappaB signal transduction [GO:0007249]; circadian regulation of gene expression [GO:0032922]; defense response to bacterium [GO:0042742]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of type 2 mitophagy [GO:1905091]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein branched polyubiquitination [GO:0141198]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]	DNA binding [GO:0003677]; histone ubiquitin ligase activity [GO:0140852]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm end piece [GO:0097229]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0000139; GO:0000209; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0006284; GO:0006511; GO:0006513; GO:0007030; GO:0007249; GO:0010637; GO:0031398; GO:0031965; GO:0032922; GO:0034450; GO:0035357; GO:0035359; GO:0042742; GO:0043123; GO:0043124; GO:0043161; GO:0061025; GO:0061630; GO:0070936; GO:0097225; GO:0097228; GO:0097229; GO:0140852; GO:0141198; GO:1905091
GN019367	GN019367.1	Q28I85	82.1	56	465	441	2.14e-21	99.8	POC1A_XENTR	POC1 centriolar protein homolog A (Pat-interacting protein 2) (Pix2) (xPix2) (WD repeat-containing protein 51A)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cilium assembly [GO:0060271]; microtubule-based process [GO:0007017]; multicellular organismal-level homeostasis [GO:0048871]		centriole [GO:0005814]; ciliary basal body [GO:0036064]	GO:0005814; GO:0007017; GO:0036064; GO:0048871; GO:0060271
GN019368	GN019368.1	Q6DQX6	33.1	118	169	151	2.71e-09	56.2	NDUBB_CRIGR	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (CI-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)			mitochondrial inner membrane [GO:0005743]; respiratory chain complex I [GO:0045271]	GO:0005743; GO:0045271
GN019369	GN019369.1	Q6ZSM3	25.9	316	302	516	1.96e-19	91.7	MOT12_HUMAN	Monocarboxylate transporter 12 (MCT 12) (Creatine transporter 2) (CRT2) (Solute carrier family 16 member 12)	Homo sapiens (Human)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]; transport across blood-brain barrier [GO:0150104]	creatine transmembrane transporter activity [GO:0005308]; transmembrane transporter activity [GO:0022857]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0022857; GO:0046449; GO:0150104
GN019371	GN019371.1	A7RX26	55.8	274	286	429	6.97e-107	320	HUTI_NEMVE	Probable imidazolonepropionase (EC 3.5.2.7) (Amidohydrolase domain-containing protein 1 homolog)	Nematostella vectensis (Starlet sea anemone)	L-histidine catabolic process [GO:0006548]	imidazolonepropionase activity [GO:0050480]	cytoplasm [GO:0005737]	GO:0005737; GO:0006548; GO:0050480
GN019372	GN019372.1	P48728	58.4	334	461	403	5.00e-132	390	GCST_HUMAN	Aminomethyltransferase, mitochondrial (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT)	Homo sapiens (Human)	glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]	aminomethyltransferase activity [GO:0004047]	glycine cleavage complex [GO:0005960]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004047; GO:0005739; GO:0005759; GO:0005960; GO:0006546; GO:0019464
GN019373	GN019373.1	Q5XTS1	42.2	427	651	786	8.02e-115	365	PLPL8_RABIT	Calcium-independent phospholipase A2-gamma (EC 3.1.1.-) (EC 3.1.1.5) (Group VIB calcium-independent phospholipase A2) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (Patatin-like phospholipase domain-containing protein 8)	Oryctolagus cuniculus (Rabbit)	arachidonate metabolic process [GO:0019369]; cardiolipin metabolic process [GO:0032048]; lipid homeostasis [GO:0055088]; triglyceride homeostasis [GO:0070328]	A2-type glycerophospholipase activity [GO:0004623]; glycerophospholipid phospholipase A1 activity [GO:0008970]; phosphatidylcholine lysophospholipase A1 activity [GO:0004622]	endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0004622; GO:0004623; GO:0005739; GO:0005777; GO:0005778; GO:0005789; GO:0008970; GO:0016020; GO:0019369; GO:0031966; GO:0032048; GO:0055088; GO:0070328
GN019374	GN019374.1	Q05B18	45.3	338	405	604	1.50e-95	301	SHQ1_XENTR	Protein SHQ1 homolog	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	box H/ACA snoRNP assembly [GO:0000493]; protein-RNA complex assembly [GO:0022618]		cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0000493; GO:0005654; GO:0005829; GO:0022618
GN019379	GN019379.1	Q8K3K9	38.2	220	380	310	6.16e-38	141	GIMA4_RAT	GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4)	Rattus norvegicus (Rat)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]	GO:0003924; GO:0005525; GO:0005829
GN019384	GN019384.1	Q66HY7	51.6	182	222	224	2.74e-72	222	IF4E3_DANRE	Eukaryotic translation initiation factor 4E type 3 (eIF-4E type 3) (eIF-4E3) (eIF4E type 3) (eIF4E-3)	Danio rerio (Zebrafish) (Brachydanio rerio)	translational initiation [GO:0006413]	RNA 7-methylguanosine cap binding [GO:0000340]; translation initiation factor activity [GO:0003743]	eukaryotic translation initiation factor 4F complex [GO:0016281]	GO:0000340; GO:0003743; GO:0006413; GO:0016281
GN019387	GN019387.1	Q9D4D4	65.1	573	579	627	1.13e-273	763	TKTL2_MOUSE	Transketolase-like protein 2 (EC 2.2.1.1)	Mus musculus (Mouse)	pentose-phosphate shunt, non-oxidative branch [GO:0009052]	thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004802; GO:0005737; GO:0005829; GO:0009052; GO:0030976
GN019388	GN019388.1	Q53HV7	48.1	241	632	270	3.38e-77	249	SMUG1_HUMAN	Single-strand selective monofunctional uracil DNA glycosylase (EC 3.2.2.-)	Homo sapiens (Human)	base-excision repair [GO:0006284]; depyrimidination [GO:0045008]	DNA N-glycosylase activity [GO:0019104]; identical protein binding [GO:0042802]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]; single-strand selective uracil DNA N-glycosylase activity [GO:0017065]; uracil DNA N-glycosylase activity [GO:0004844]	fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0000703; GO:0001650; GO:0004844; GO:0005654; GO:0005730; GO:0006284; GO:0017065; GO:0019104; GO:0042802; GO:0045008
GN019390	GN019390.1	Q5RCE1	66.4	110	122	445	3.58e-45	154	GDIB_PONAB	Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	negative regulation of cilium assembly [GO:1902018]; negative regulation of protein localization to cilium [GO:1903565]; protein transport [GO:0015031]; small GTPase-mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]	Rab GDP-dissociation inhibitor activity [GO:0005093]	Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0005093; GO:0005794; GO:0007264; GO:0015031; GO:0016020; GO:0016192; GO:1902018; GO:1903565
GN019391	GN019391.1	Q5XPI4	37.3	1296	1225	1314	2.66e-279	827	RN123_HUMAN	E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123)	Homo sapiens (Human)	modification-dependent protein catabolic process [GO:0019941]; protein maturation [GO:0051604]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000209; GO:0005737; GO:0005829; GO:0006511; GO:0019941; GO:0051604; GO:0051726; GO:0061630
GN019396	GN019396.1	P33316	69.9	133	145	252	2.34e-61	192	DUT_HUMAN	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)	Homo sapiens (Human)	DNA replication [GO:0006260]; dTMP biosynthetic process [GO:0006231]; dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]; liver development [GO:0001889]; nucleobase-containing compound metabolic process [GO:0006139]; regulation of protein-containing complex assembly [GO:0043254]	dUTP diphosphatase activity [GO:0004170]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; peroxisome proliferator activated receptor binding [GO:0042975]; pyrimidine deoxyribonucleotide binding [GO:0032556]; RNA binding [GO:0003723]; signaling receptor inhibitor activity [GO:0030547]	extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0001889; GO:0003723; GO:0004170; GO:0005634; GO:0005654; GO:0005739; GO:0006139; GO:0006226; GO:0006231; GO:0006260; GO:0030547; GO:0032556; GO:0042802; GO:0042975; GO:0043254; GO:0046081; GO:0070062
GN019397	GN019397.1	Q62165	28.5	864	839	893	1.01e-73	262	DAG1_MOUSE	Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]	Mus musculus (Mouse)	angiogenesis involved in wound healing [GO:0060055]; axon guidance [GO:0007411]; axon regeneration [GO:0031103]; basement membrane organization [GO:0071711]; branching involved in salivary gland morphogenesis [GO:0060445]; calcium-dependent cell-matrix adhesion [GO:0016340]; cell surface receptor signaling pathway [GO:0007166]; cellular response to cholesterol [GO:0071397]; cellular response to mechanical stimulus [GO:0071260]; commissural neuron axon guidance [GO:0071679]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; extracellular matrix assembly [GO:0085029]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; inhibitory synapse assembly [GO:1904862]; membrane protein ectodomain proteolysis [GO:0006509]; microtubule anchoring [GO:0034453]; morphogenesis of an epithelial sheet [GO:0002011]; morphogenesis of an epithelium [GO:0002009]; muscle attachment [GO:0016203]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cell migration [GO:0030336]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051898]; negative regulation of synaptic transmission, cholinergic [GO:0032223]; nerve development [GO:0021675]; nerve maturation [GO:0021682]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; protein localization to synapse [GO:0035418]; protein transport [GO:0015031]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of synapse organization [GO:0050807]; regulation of synaptic plasticity [GO:0048167]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to muscle activity [GO:0014850]; response to peptide hormone [GO:0043434]; retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942]; Schwann cell development [GO:0014044]; skeletal muscle tissue regeneration [GO:0043403]; synapse assembly [GO:0007416]; synaptic assembly at neuromuscular junction [GO:0051124]	actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; calcium ion binding [GO:0005509]; dystroglycan binding [GO:0002162]; heparan sulfate proteoglycan binding [GO:0043395]; identical protein binding [GO:0042802]; laminin binding [GO:0043236]; laminin receptor activity [GO:0005055]; laminin-1 binding [GO:0043237]; protein-containing complex binding [GO:0044877]; serine-type endopeptidase activity [GO:0004252]; SH2 domain binding [GO:0042169]; signaling receptor activity [GO:0038023]; structural constituent of muscle [GO:0008307]; tubulin binding [GO:0015631]; vinculin binding [GO:0017166]; virus receptor activity [GO:0001618]	adherens junction [GO:0005912]; basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; contractile ring [GO:0070938]; costamere [GO:0043034]; cytoplasm [GO:0005737]; dystroglycan complex [GO:0016011]; dystrophin-associated glycoprotein complex [GO:0016010]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; inhibitory synapse [GO:0060077]; lamellipodium [GO:0030027]; membrane [GO:0016020]; membrane raft [GO:0045121]; node of Ranvier [GO:0033268]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynapse [GO:0098794]; postsynaptic cytosol [GO:0099524]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; synapse [GO:0045202]	GO:0001618; GO:0001954; GO:0002009; GO:0002011; GO:0002162; GO:0003007; GO:0003779; GO:0004252; GO:0005055; GO:0005509; GO:0005576; GO:0005604; GO:0005654; GO:0005737; GO:0005886; GO:0005911; GO:0005912; GO:0005925; GO:0006509; GO:0007166; GO:0007411; GO:0007416; GO:0007507; GO:0008307; GO:0009897; GO:0009986; GO:0014044; GO:0014850; GO:0014894; GO:0015031; GO:0015631; GO:0016010; GO:0016011; GO:0016020; GO:0016203; GO:0016323; GO:0016340; GO:0017166; GO:0021675; GO:0021682; GO:0022011; GO:0030027; GO:0030175; GO:0030336; GO:0031103; GO:0031643; GO:0032223; GO:0033268; GO:0034399; GO:0034453; GO:0035022; GO:0035418; GO:0038023; GO:0042169; GO:0042383; GO:0042802; GO:0043034; GO:0043236; GO:0043237; GO:0043395; GO:0043403; GO:0043409; GO:0043434; GO:0044853; GO:0044877; GO:0045121; GO:0045202; GO:0045211; GO:0045860; GO:0048167; GO:0048714; GO:0050807; GO:0051124; GO:0051393; GO:0051897; GO:0051898; GO:0060055; GO:0060077; GO:0060441; GO:0060445; GO:0070938; GO:0071260; GO:0071397; GO:0071679; GO:0071711; GO:0085029; GO:0098684; GO:0098696; GO:0098794; GO:0098942; GO:0098978; GO:0098982; GO:0099524; GO:1904395; GO:1904862
GN019398	GN019398.1	Q3TA59	35.0	234	582	269	8.50e-27	113	JMJD8_MOUSE	JmjC domain-containing protein 8 (Jumonji domain-containing protein 8)	Mus musculus (Mouse)	cellular respiration [GO:0045333]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of sprouting angiogenesis [GO:1903672]; regulation of glycolytic process [GO:0006110]; regulation of pyruvate kinase activity [GO:1903302]; sprouting angiogenesis [GO:0002040]		cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; nucleus [GO:0005634]	GO:0002040; GO:0005634; GO:0005737; GO:0005783; GO:0005788; GO:0006110; GO:0043123; GO:0045333; GO:1903302; GO:1903672
GN019399	GN019399.1	P35408	25.2	330	309	488	2.29e-15	79.7	PE2R4_HUMAN	Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine production [GO:0001818]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of stress fiber assembly [GO:0051492]; response to mechanical stimulus [GO:0009612]; response to prostaglandin E [GO:0034695]; T-helper cell differentiation [GO:0042093]	prostaglandin E receptor activity [GO:0004957]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001818; GO:0001819; GO:0004957; GO:0005886; GO:0006954; GO:0006955; GO:0007188; GO:0007189; GO:0007193; GO:0007204; GO:0007254; GO:0009612; GO:0016020; GO:0033624; GO:0034695; GO:0042093; GO:0050728; GO:0050729; GO:0051492; GO:0060348; GO:0070371; GO:0071260; GO:0071380; GO:2000420
GN019402	GN019402.1	Q7A551	31.9	160	159	166	6.96e-12	63.2	Y1532_STAAN	Putative universal stress protein SA1532	Staphylococcus aureus (strain N315)			cytoplasm [GO:0005737]	GO:0005737
GN019403	GN019403.1	Q5S007	29.4	2689	2669	2527	3.20e-288	927	LRRK2_HUMAN	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	Homo sapiens (Human)	calcium-mediated signaling [GO:0019722]; canonical Wnt signaling pathway [GO:0060070]; cellular response to curcumin [GO:1904644]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; endoplasmic reticulum organization [GO:0007029]; excitatory postsynaptic potential [GO:0060079]; exploration behavior [GO:0035640]; Golgi organization [GO:0007030]; GTP metabolic process [GO:0046039]; intracellular distribution of mitochondria [GO:0048312]; intracellular protein localization [GO:0008104]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; locomotory exploration behavior [GO:0035641]; lysosome organization [GO:0007040]; MAPK cascade [GO:0000165]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of GTPase activity [GO:0034260]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of macroautophagy [GO:0016242]; negative regulation of motile cilium assembly [GO:1905504]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein localization to mitochondrion [GO:1903748]; negative regulation of protein processing [GO:0010955]; neuromuscular junction development [GO:0007528]; neuron projection arborization [GO:0140058]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; positive regulation of tumor necrosis factor production [GO:0032760]; protein autophosphorylation [GO:0046777]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to mitochondrion [GO:0070585]; protein phosphorylation [GO:0006468]; regulation of autophagy [GO:0010506]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of CAMKK-AMPK signaling cascade [GO:1905289]; regulation of cAMP/PKA signal transduction [GO:0141161]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell projection organization [GO:0031344]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of kidney size [GO:0035564]; regulation of locomotion [GO:0040012]; regulation of membrane potential [GO:0042391]; regulation of mitochondrial depolarization [GO:0051900]; regulation of mitochondrial fission [GO:0090140]; regulation of neuroblast proliferation [GO:1902692]; regulation of neuron maturation [GO:0014041]; regulation of protein stability [GO:0031647]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle transport [GO:1902803]; response to oxidative stress [GO:0006979]; Rho protein signal transduction [GO:0007266]; spermatogenesis [GO:0007283]; striatum development [GO:0021756]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; Wnt signalosome assembly [GO:1904887]	actin binding [GO:0003779]; ATP binding [GO:0005524]; beta-catenin destruction complex binding [GO:1904713]; clathrin binding [GO:0030276]; co-receptor binding [GO:0039706]; GTP binding [GO:0005525]; GTP-dependent protein kinase activity [GO:0034211]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; JUN kinase kinase kinase activity [GO:0004706]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; microtubule binding [GO:0008017]; peroxidase inhibitor activity [GO:0036479]; protein homodimerization activity [GO:0042803]; protein kinase A binding [GO:0051018]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; signaling receptor complex adaptor activity [GO:0030159]; small GTPase binding [GO:0031267]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]; transmembrane transporter binding [GO:0044325]; tubulin binding [GO:0015631]	amphisome [GO:0044753]; autolysosome [GO:0044754]; axon [GO:0030424]; caveola neck [GO:0099400]; cytoplasm [GO:0005737]; cytoplasmic side of mitochondrial outer membrane [GO:0032473]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; growth cone [GO:0030426]; Lewy body [GO:0097413]; lysosome [GO:0005764]; microvillus [GO:0005902]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body, internal vesicle [GO:0097487]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic cytosol [GO:0099523]; ribonucleoprotein complex [GO:1990904]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; trans-Golgi network [GO:0005802]; Wnt signalosome [GO:1990909]	GO:0000139; GO:0000149; GO:0000165; GO:0000287; GO:0003779; GO:0003924; GO:0004672; GO:0004674; GO:0004706; GO:0004709; GO:0005096; GO:0005524; GO:0005525; GO:0005576; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005764; GO:0005768; GO:0005783; GO:0005789; GO:0005794; GO:0005798; GO:0005802; GO:0005829; GO:0005886; GO:0005902; GO:0006468; GO:0006897; GO:0006979; GO:0007005; GO:0007029; GO:0007030; GO:0007040; GO:0007254; GO:0007266; GO:0007283; GO:0007528; GO:0008017; GO:0008104; GO:0008340; GO:0009267; GO:0010506; GO:0010508; GO:0010955; GO:0010977; GO:0014041; GO:0015631; GO:0016242; GO:0016301; GO:0017075; GO:0019722; GO:0021756; GO:0021772; GO:0022028; GO:0030159; GO:0030276; GO:0030424; GO:0030425; GO:0030426; GO:0030672; GO:0031267; GO:0031344; GO:0031398; GO:0031410; GO:0031647; GO:0031966; GO:0032436; GO:0032473; GO:0032760; GO:0032839; GO:0034211; GO:0034260; GO:0034599; GO:0034614; GO:0035542; GO:0035556; GO:0035564; GO:0035640; GO:0035641; GO:0036479; GO:0039706; GO:0040012; GO:0042391; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0043068; GO:0043195; GO:0043204; GO:0043410; GO:0044325; GO:0044753; GO:0044754; GO:0045335; GO:0046039; GO:0046777; GO:0048312; GO:0048812; GO:0051018; GO:0051646; GO:0051900; GO:0051966; GO:0060070; GO:0060079; GO:0060159; GO:0060161; GO:0060628; GO:0060828; GO:0061001; GO:0070062; GO:0070585; GO:0070971; GO:0070973; GO:0071287; GO:0090140; GO:0090263; GO:0090394; GO:0097413; GO:0097487; GO:0098794; GO:0098978; GO:0099400; GO:0099523; GO:0106310; GO:0140058; GO:0141161; GO:1900242; GO:1900244; GO:1901030; GO:1902236; GO:1902499; GO:1902692; GO:1902803; GO:1902823; GO:1902902; GO:1903351; GO:1903748; GO:1903980; GO:1904644; GO:1904713; GO:1904887; GO:1905279; GO:1905289; GO:1905504; GO:1990904; GO:1990909; GO:2000172; GO:2000300; GO:2000377
GN019404	GN019404.1	Q9HBM0	25.8	834	784	779	8.85e-31	133	VEZA_HUMAN	Vezatin	Homo sapiens (Human)	cell-cell adhesion [GO:0098609]	myosin binding [GO:0017022]	acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilia ankle link complex [GO:0002142]; stereocilium membrane [GO:0060171]	GO:0001669; GO:0002142; GO:0005634; GO:0005654; GO:0005886; GO:0005912; GO:0017022; GO:0060171; GO:0098609
GN019405	GN019405.1	M9PBE2	61.9	134	493	473	2.56e-49	179	HAKAI_DROME	E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27)	Drosophila melanogaster (Fruit fly)	actin filament organization [GO:0007015]; chitin-based cuticle development [GO:0040003]; dorsal closure [GO:0007391]; epithelial cell migration, open tracheal system [GO:0007427]; epithelium development [GO:0060429]; female sex determination [GO:0030237]; head involution [GO:0008258]; midgut development [GO:0007494]; protein ubiquitination [GO:0016567]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of cell adhesion [GO:0030155]; segmentation [GO:0035282]; sex differentiation [GO:0007548]	cadherin binding [GO:0045296]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]	GO:0000381; GO:0004842; GO:0005634; GO:0005829; GO:0005886; GO:0007015; GO:0007391; GO:0007427; GO:0007494; GO:0007548; GO:0008258; GO:0008270; GO:0016567; GO:0030155; GO:0030237; GO:0031410; GO:0035282; GO:0036396; GO:0040003; GO:0045296; GO:0048471; GO:0060429; GO:0061630
GN019407	GN019407.1	O14522	42.7	218	720	1441	9.71e-45	177	PTPRT_HUMAN	Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho)	Homo sapiens (Human)	cell adhesion [GO:0007155]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to interleukin-6 [GO:0071354]; homophilic cell-cell adhesion [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]	alpha-actinin binding [GO:0051393]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine phosphatase activity [GO:0004725]; STAT family protein binding [GO:0097677]; thiolester hydrolase activity [GO:0016790]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	cell surface [GO:0009986]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0004725; GO:0005001; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016020; GO:0016790; GO:0019903; GO:0030336; GO:0031175; GO:0042803; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097; GO:0071354; GO:0097677; GO:1904893
GN019409	GN019409.1	B9FAF3	46.1	358	678	1080	8.23e-93	313	KN14E_ORYSJ	Kinesin-like protein KIN-14E	Oryza sativa subsp. japonica (Rice)	microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	microtubule cytoskeleton [GO:0015630]	GO:0003777; GO:0005524; GO:0007017; GO:0007018; GO:0008017; GO:0015630
GN019413	GN019413.1	Q07E28	31.0	1471	1761	1658	1.19e-93	340	CTTB2_NEONE	Cortactin-binding protein 2 (CortBP2)	Neofelis nebulosa (Clouded leopard)		protein phosphatase 2A binding [GO:0051721]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]	GO:0005938; GO:0015629; GO:0043197; GO:0051721; GO:0090443
GN019415	GN019415.1	O77469	50.0	58	73	728	1.72e-11	60.8	FBLN1_CAEEL	Fibulin-1	Caenorhabditis elegans	extracellular matrix organization [GO:0030198]; intracellular protein localization [GO:0008104]; positive regulation of locomotion [GO:0040017]	calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; peptidase activator activity [GO:0016504]	basement membrane [GO:0005604]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005201; GO:0005509; GO:0005576; GO:0005604; GO:0008104; GO:0016504; GO:0030198; GO:0031012; GO:0040017
GN019416	GN019416.1	Q9WVJ9	38.8	147	398	443	2.25e-16	84.0	FBLN4_MOUSE	EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Mutant p53-binding protein 1)	Mus musculus (Mouse)	aorta development [GO:0035904]; aorta smooth muscle tissue morphogenesis [GO:0060414]; artery development [GO:0060840]; elastic fiber assembly [GO:0048251]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of aortic smooth muscle cell differentiation [GO:1904831]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of smooth muscle cell-matrix adhesion [GO:1905609]; regulation of collagen fibril organization [GO:1904026]; vascular associated smooth muscle cell development [GO:0097084]	calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; protein homodimerization activity [GO:0042803]	basement membrane [GO:0005604]; elastic fiber [GO:0071953]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; non-collagenous component of basement membrane [GO:0140144]	GO:0005509; GO:0005576; GO:0005604; GO:0008201; GO:0031012; GO:0035904; GO:0042803; GO:0048251; GO:0060414; GO:0060840; GO:0071953; GO:0097084; GO:0140144; GO:1904026; GO:1904028; GO:1904706; GO:1904831; GO:1905609
GN019417	GN019417.1	Q86UP9	43.7	215	255	236	5.01e-61	195	LHPL3_HUMAN	LHFPL tetraspan subfamily member 3 protein (Lipoma HMGIC fusion partner-like 3 protein)	Homo sapiens (Human)	sensory perception of sound [GO:0007605]		plasma membrane [GO:0005886]	GO:0005886; GO:0007605
GN019419	GN019419.1	D8VNS7	48.8	123	151	345	2.24e-36	130	FCNV1_CERRY	Ryncolin-1	Cerberus rynchops (Dog-faced water snake)	complement activation, lectin pathway [GO:0001867]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0001867; GO:0003823; GO:0005102; GO:0005576; GO:0097367
GN019420	GN019420.1	Q9V4A7	34.8	2020	1901	2051	0.0	1002	PLXB_DROME	Plexin-B	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; motor neuron axon guidance [GO:0008045]; negative regulation of cell adhesion [GO:0007162]; olfactory bulb axon guidance [GO:0071678]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; semaphorin-plexin signaling pathway [GO:0071526]; sensory neuron axon guidance [GO:0097374]; synapse assembly [GO:0007416]	semaphorin receptor activity [GO:0017154]	dendrite [GO:0030425]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]	GO:0002116; GO:0005886; GO:0007162; GO:0007411; GO:0007416; GO:0008045; GO:0008360; GO:0017154; GO:0030334; GO:0030425; GO:0050772; GO:0070593; GO:0071526; GO:0071678; GO:0097374
GN019421	GN019421.1	P53356	32.0	150	422	757	1.03e-10	67.4	HTK16_HYDVU	Tyrosine-protein kinase HTK16 (EC 2.7.10.2)	Hydra vulgaris (Hydra) (Hydra attenuata)		ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]		GO:0004715; GO:0005524
GN019423	GN019423.1	Q91783	38.9	95	627	1067	9.27e-11	68.9	KI11A_XENLA	Kinesin-like protein KIF11-A (Kinesin-5) (Kinesin-related motor protein Eg5-2) (XLEg5K2)	Xenopus laevis (African clawed frog)	microtubule-based movement [GO:0007018]; mitotic spindle assembly [GO:0090307]; spindle elongation [GO:0051231]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]	cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]	GO:0000922; GO:0003777; GO:0005524; GO:0005634; GO:0005737; GO:0005876; GO:0007018; GO:0008017; GO:0008574; GO:0051231; GO:0072686; GO:0090307
GN019424	GN019424.1	B2GU58	67.9	308	305	1067	5.75e-128	393	KIF11_XENTR	Kinesin-like protein KIF11 (Costal2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	microtubule-based movement [GO:0007018]; mitotic spindle assembly [GO:0090307]; spindle elongation [GO:0051231]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; plus-end-directed microtubule motor activity [GO:0008574]; protein kinase binding [GO:0019901]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]	GO:0000922; GO:0003777; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005876; GO:0007018; GO:0008017; GO:0008574; GO:0019901; GO:0051231; GO:0072686; GO:0090307
GN019425	GN019425.1	P78504	27.7	206	514	1218	2.70e-14	79.7	JAG1_HUMAN	Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)	Homo sapiens (Human)	angiogenesis [GO:0001525]; aorta morphogenesis [GO:0035909]; aortic valve morphogenesis [GO:0003180]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cell fate determination [GO:0001709]; distal tubule development [GO:0072017]; endocardial cushion cell development [GO:0061444]; endothelial cell differentiation [GO:0045446]; hemopoiesis [GO:0030097]; inner ear development [GO:0048839]; keratinocyte differentiation [GO:0030216]; loop of Henle development [GO:0072070]; myoblast differentiation [GO:0045445]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of stem cell differentiation [GO:2000737]; nephron development [GO:0072006]; nervous system development [GO:0007399]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; podocyte development [GO:0072015]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of cell population proliferation [GO:0042127]; response to muramyl dipeptide [GO:0032495]; T cell mediated immunity [GO:0002456]	calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; molecular adaptor activity [GO:0060090]; Notch binding [GO:0005112]; phospholipid binding [GO:0005543]; structural molecule activity [GO:0005198]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001525; GO:0001709; GO:0001953; GO:0002456; GO:0003180; GO:0003184; GO:0003215; GO:0005112; GO:0005198; GO:0005509; GO:0005543; GO:0005576; GO:0005886; GO:0005912; GO:0007219; GO:0007399; GO:0008083; GO:0016020; GO:0016324; GO:0022408; GO:0030097; GO:0030216; GO:0030336; GO:0032495; GO:0035909; GO:0042127; GO:0045445; GO:0045446; GO:0045602; GO:0045747; GO:0045944; GO:0048839; GO:0060090; GO:0060411; GO:0061156; GO:0061309; GO:0061444; GO:0062043; GO:0072006; GO:0072015; GO:0072017; GO:0072070; GO:0097150; GO:2000737
GN019426	GN019426.1	Q9HCE0	30.1	2365	2641	2579	0.0	1055	EPG5_HUMAN	Ectopic P granules protein 5 homolog	Homo sapiens (Human)	autophagosome maturation [GO:0097352]; cellular response to dsDNA [GO:1990786]; endosome to lysosome transport [GO:0008333]; nucleotide transport [GO:0006862]; toll-like receptor 9 signaling pathway [GO:0034162]		cytoplasm [GO:0005737]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]	GO:0005737; GO:0005764; GO:0006862; GO:0008333; GO:0034162; GO:0048471; GO:0097352; GO:1990786
GN019428	GN019428.1	Q53G44	38.2	249	473	452	4.14e-47	172	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN019429	GN019429.1	Q53G44	30.8	458	466	452	1.29e-49	178	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN019430	GN019430.1	Q53G44	27.0	459	472	452	4.64e-38	147	IF44L_HUMAN	Interferon-induced protein 44-like	Homo sapiens (Human)	defense response to virus [GO:0051607]; immune response [GO:0006955]		cytosol [GO:0005829]	GO:0005829; GO:0006955; GO:0051607
GN019431	GN019431.1	Q9D581	35.7	129	141	132	2.10e-22	89.0	EFC10_MOUSE	EF-hand calcium-binding domain-containing protein 10	Mus musculus (Mouse)		calcium ion binding [GO:0005509]		GO:0005509
GN019432	GN019432.1	Q6NRH0	64.4	351	563	564	4.35e-158	466	KLH12_XENLA	Kelch-like protein 12	Xenopus laevis (African clawed frog)	COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; Wnt signaling pathway [GO:0016055]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]	GO:0005737; GO:0006513; GO:0006888; GO:0014029; GO:0014032; GO:0016055; GO:0030127; GO:0030134; GO:0031463; GO:0043161; GO:0048208; GO:1990756
GN019433	GN019433.1	Q00536	61.6	516	495	496	2.05e-210	594	CDK16_HUMAN	Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)	Homo sapiens (Human)	exocytosis [GO:0006887]; growth hormone secretion [GO:0030252]; neuron projection development [GO:0031175]; positive regulation of autophagy [GO:0010508]; protein phosphorylation [GO:0006468]; regulation of cell cycle phase transition [GO:1901987]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; spermatogenesis [GO:0007283]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GO:0000307; GO:0004674; GO:0004693; GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0006468; GO:0006887; GO:0007283; GO:0008021; GO:0009898; GO:0010508; GO:0030252; GO:0031175; GO:0061178; GO:0106310; GO:1901987
GN019435	GN019435.1	Q96M69	49.0	500	791	825	6.27e-89	301	LRGUK_HUMAN	Leucine-rich repeat and guanylate kinase domain-containing protein	Homo sapiens (Human)	axoneme assembly [GO:0035082]; spermatogenesis [GO:0007283]		acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; manchette [GO:0002177]	GO:0001669; GO:0002177; GO:0005829; GO:0007283; GO:0035082
GN019436	GN019436.1	Q13569	57.5	240	656	410	7.90e-75	249	TDG_HUMAN	G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (Thymine-DNA glycosylase) (hTDG)	Homo sapiens (Human)	base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; chromosomal 5-methylcytosine DNA demethylation, oxidation pathway [GO:0141167]; depyrimidination [GO:0045008]; epigenetic regulation of gene expression [GO:0040029]; regulation of embryonic development [GO:0045995]	ATP binding [GO:0005524]; chloride ion binding [GO:0031404]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]; double-stranded DNA binding [GO:0003690]; G/T mismatch-specific thymine-DNA glycosylase activity [GO:0141016]; G/U mismatch-specific uracil-DNA glycosylase activity [GO:0043739]; magnesium ion binding [GO:0000287]; mismatched DNA binding [GO:0030983]; nucleic acid binding [GO:0003676]; protein kinase C binding [GO:0005080]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; sodium ion binding [GO:0031402]; SUMO binding [GO:0032183]; transcription coregulator activity [GO:0003712]; uracil DNA N-glycosylase activity [GO:0004844]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0000287; GO:0003676; GO:0003677; GO:0003684; GO:0003690; GO:0003712; GO:0004844; GO:0005080; GO:0005524; GO:0005634; GO:0005654; GO:0006284; GO:0006285; GO:0008263; GO:0016605; GO:0019104; GO:0030983; GO:0031402; GO:0031404; GO:0032183; GO:0040029; GO:0043739; GO:0045008; GO:0045995; GO:0141016; GO:0141167
GN019438	GN019438.1	P42325	66.1	186	257	190	1.30e-88	263	NCAH_DROME	Neurocalcin homolog (DrosNCa)	Drosophila melanogaster (Fruit fly)	negative regulation of neuronal signal transduction [GO:1902848]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; regulation of signal transduction [GO:0009966]	calcium ion binding [GO:0005509]		GO:0005509; GO:0009966; GO:0045938; GO:1902848
GN019439	GN019439.1	Q6P542	65.5	597	723	837	5.12e-263	750	ABCF1_MOUSE	ATP-binding cassette sub-family F member 1	Mus musculus (Mouse)	positive regulation of translation [GO:0045727]; translational initiation [GO:0006413]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ribosome binding [GO:0043022]; translation activator activity [GO:0008494]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]	GO:0005524; GO:0005635; GO:0005654; GO:0005737; GO:0005829; GO:0005840; GO:0006413; GO:0008494; GO:0016887; GO:0043022; GO:0045727
GN019441	GN019441.1	Q5RC32	29.9	291	1094	724	2.66e-16	87.8	SAXO6_PONAB	Stabilizer of axonemal microtubules 6 (Nuclear protein MDM1)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	negative regulation of centriole replication [GO:0046600]; retina development in camera-type eye [GO:0060041]	microtubule binding [GO:0008017]	centriole [GO:0005814]; centrosome [GO:0005813]; nucleus [GO:0005634]	GO:0005634; GO:0005813; GO:0005814; GO:0008017; GO:0046600; GO:0060041
GN019443	GN019443.1	B3EWZ6	41.3	143	217	7311	4.26e-20	91.7	MLRP2_ACRMI	MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN019444	GN019444.1	O60870	71.1	201	208	393	7.81e-99	295	KIN17_HUMAN	DNA/RNA-binding protein KIN17 (Binding to curved DNA) (KIN, antigenic determinant of recA protein homolog)	Homo sapiens (Human)	DNA damage response [GO:0006974]; DNA replication [GO:0006260]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]	DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0000398; GO:0003677; GO:0003690; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0005829; GO:0006260; GO:0006397; GO:0006974; GO:0016363; GO:0032991; GO:0071006
GN019445	GN019445.1	Q5R5P3	49.0	665	738	743	4.36e-210	612	THNS1_PONAB	Threonine synthase-like 1 (TSH1)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)			cytoplasm [GO:0005737]	GO:0005737
GN019447	GN019447.1	Q5BKN5	49.7	308	324	335	6.55e-93	282	CD123_XENTR	Translation initiation factor eIF2 assembly protein (Cell division cycle protein 123 homolog)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	eukaryotic translation initiation factor 2 complex assembly [GO:1905143]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein folding chaperone [GO:0044183]	cytoplasm [GO:0005737]	GO:0000287; GO:0005524; GO:0005737; GO:0044183; GO:1905143
GN019448	GN019448.1	Q16539	73.6	349	353	360	4.06e-190	531	MK14_HUMAN	Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)	Homo sapiens (Human)	3'-UTR-mediated mRNA stabilization [GO:0070935]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ionizing radiation [GO:0071479]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to UV-B [GO:0071493]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular response to virus [GO:0098586]; cellular senescence [GO:0090398]; chemotaxis [GO:0006935]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; negative regulation of hippo signaling [GO:0035331]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; osteoclast differentiation [GO:0030316]; p38MAPK cascade [GO:0038066]; platelet activation [GO:0030168]; positive regulation of cyclase activity [GO:0031281]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]; stress-induced premature senescence [GO:0090400]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; mitogen-activated protein kinase p38 binding [GO:0048273]; NFAT protein binding [GO:0051525]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]	GO:0000165; GO:0002862; GO:0004674; GO:0004707; GO:0004708; GO:0005524; GO:0005576; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006357; GO:0006935; GO:0007165; GO:0007166; GO:0010628; GO:0010831; GO:0016607; GO:0019899; GO:0019903; GO:0030168; GO:0030316; GO:0031098; GO:0031281; GO:0032735; GO:0034774; GO:0035331; GO:0035556; GO:0035924; GO:0038066; GO:0042770; GO:0045648; GO:0045663; GO:0048010; GO:0048273; GO:0051149; GO:0051403; GO:0051525; GO:0070935; GO:0071222; GO:0071223; GO:0071479; GO:0071493; GO:0090398; GO:0090400; GO:0098586; GO:0106310; GO:1900015; GO:1901741; GO:1904813; GO:2000379
GN019450	GN019450.1	P07948	24.3	230	241	512	1.74e-09	60.8	LYN_HUMAN	Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)	Homo sapiens (Human)	B cell homeostasis [GO:0001782]; B cell proliferation [GO:0042100]; C-X-C chemokine receptor CXCR4 signaling pathway [GO:0038159]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to heat [GO:0034605]; cellular response to retinoic acid [GO:0071300]; dendritic cell differentiation [GO:0097028]; DNA damage checkpoint signaling [GO:0000077]; DNA damage response [GO:0006974]; eosinophil differentiation [GO:0030222]; ephrin receptor signaling pathway [GO:0048013]; erythrocyte differentiation [GO:0030218]; fatty acid transport [GO:0015908]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; Fc receptor mediated stimulatory signaling pathway [GO:0002431]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; growth hormone receptor signaling pathway via JAK-STAT [GO:0060397]; hematopoietic progenitor cell differentiation [GO:0002244]; histamine secretion by mast cell [GO:0002553]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; inflammatory response [GO:0006954]; interleukin-5-mediated signaling pathway [GO:0038043]; leukocyte migration [GO:0050900]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of immune response [GO:0050777]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of intracellular signal transduction [GO:1902532]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of mast cell proliferation [GO:0070667]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; neuron projection development [GO:0031175]; oligodendrocyte development [GO:0014003]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet degranulation [GO:0002576]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060369]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mast cell proliferation [GO:0070668]; positive regulation of neuron projection development [GO:0010976]; positive regulation of oligodendrocyte progenitor proliferation [GO:0070447]; positive regulation of phosphorylation [GO:0042327]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of B cell receptor signaling pathway [GO:0050855]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cytokine production [GO:0001817]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of erythrocyte differentiation [GO:0045646]; regulation of mast cell activation [GO:0033003]; regulation of mast cell degranulation [GO:0043304]; regulation of monocyte chemotaxis [GO:0090025]; regulation of platelet aggregation [GO:0090330]; regulation of protein phosphorylation [GO:0001932]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; response to amino acid [GO:0043200]; response to axon injury [GO:0048678]; response to carbohydrate [GO:0009743]; response to hormone [GO:0009725]; response to insulin [GO:0032868]; response to sterol depletion [GO:0006991]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell costimulation [GO:0031295]; tolerance induction to self antigen [GO:0002513]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; gamma-tubulin binding [GO:0043015]; glycosphingolipid binding [GO:0043208]; immunoglobulin receptor binding [GO:0034987]; integrin binding [GO:0005178]; kinase activity [GO:0016301]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphoprotein binding [GO:0051219]; phosphorylation-dependent protein binding [GO:0140031]; platelet-derived growth factor receptor binding [GO:0005161]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; signaling receptor activator activity [GO:0030546]; signaling receptor binding [GO:0005102]; transmembrane transporter binding [GO:0044325]; ubiquitin protein ligase binding [GO:0031625]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; integrin alpha2-beta1 complex [GO:0034666]; lysosomal membrane [GO:0005765]; membrane raft [GO:0045121]; mitochondrial crista [GO:0030061]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic specialization, intracellular component [GO:0099091]	GO:0000077; GO:0001782; GO:0001817; GO:0001932; GO:0001933; GO:0002223; GO:0002244; GO:0002431; GO:0002513; GO:0002553; GO:0002576; GO:0002768; GO:0002774; GO:0002862; GO:0004713; GO:0004715; GO:0005102; GO:0005161; GO:0005178; GO:0005524; GO:0005634; GO:0005737; GO:0005765; GO:0005794; GO:0005829; GO:0005886; GO:0005912; GO:0006468; GO:0006954; GO:0006974; GO:0006991; GO:0007165; GO:0007169; GO:0008284; GO:0008285; GO:0009410; GO:0009636; GO:0009725; GO:0009743; GO:0009898; GO:0010976; GO:0014003; GO:0015908; GO:0016301; GO:0018108; GO:0019899; GO:0030061; GO:0030218; GO:0030222; GO:0030546; GO:0030666; GO:0031175; GO:0031295; GO:0031625; GO:0031663; GO:0032868; GO:0033003; GO:0033628; GO:0034136; GO:0034144; GO:0034145; GO:0034165; GO:0034605; GO:0034666; GO:0034987; GO:0038043; GO:0038095; GO:0038096; GO:0038159; GO:0042100; GO:0042327; GO:0043015; GO:0043200; GO:0043208; GO:0043304; GO:0043407; GO:0043410; GO:0044325; GO:0045121; GO:0045646; GO:0046777; GO:0046875; GO:0048013; GO:0048471; GO:0048678; GO:0050777; GO:0050855; GO:0050859; GO:0050900; GO:0051219; GO:0051279; GO:0060252; GO:0060369; GO:0060397; GO:0070062; GO:0070372; GO:0070373; GO:0070447; GO:0070667; GO:0070668; GO:0071300; GO:0090025; GO:0090330; GO:0097028; GO:0097110; GO:0098978; GO:0099091; GO:0140031; GO:1902532; GO:1902993; GO:2000670
GN019452	GN019452.1	Q62186	49.0	151	174	172	2.02e-50	162	SSRD_MOUSE	Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta)	Mus musculus (Mouse)			endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; Sec61 translocon complex [GO:0005784]	GO:0005783; GO:0005784; GO:0012505
GN019453	GN019453.1	Q14416	26.3	419	1466	872	7.67e-20	100	GRM2_HUMAN	Metabotropic glutamate receptor 2 (mGluR2)	Homo sapiens (Human)	behavioral response to nicotine [GO:0035095]; chemical synaptic transmission [GO:0007268]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; glutamate secretion [GO:0014047]; negative regulation of adenylate cyclase activity [GO:0007194]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; regulation of glutamate secretion [GO:0014048]; regulation of response to drug [GO:2001023]; regulation of synaptic transmission, glutamatergic [GO:0051966]; response to cocaine [GO:0042220]	calcium channel regulator activity [GO:0005246]; G protein-coupled receptor activity [GO:0004930]; glutamate receptor activity [GO:0008066]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110]	astrocyte projection [GO:0097449]; axon [GO:0030424]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	GO:0001641; GO:0004930; GO:0005246; GO:0005886; GO:0007194; GO:0007216; GO:0007268; GO:0008066; GO:0014047; GO:0014048; GO:0014059; GO:0030424; GO:0030425; GO:0035095; GO:0042220; GO:0042734; GO:0045211; GO:0051897; GO:0051966; GO:0097110; GO:0097449; GO:0098978; GO:0099171; GO:2001023
GN019454	GN019454.1	Q86UV5	40.3	201	205	1035	4.63e-32	125	UBP48_HUMAN	Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48)	Homo sapiens (Human)	protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]; cysteine-type endopeptidase activity [GO:0004197]; deubiquitinase activity [GO:0101005]	cilium [GO:0005929]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004197; GO:0004843; GO:0005634; GO:0005654; GO:0005739; GO:0005829; GO:0005929; GO:0016579; GO:0101005
GN019455	GN019455.1	Q6PJN8	39.9	268	416	538	5.36e-51	182	DALD3_MOUSE	DALR anticodon-binding domain-containing protein 3	Mus musculus (Mouse)	arginyl-tRNA aminoacylation [GO:0006420]; tRNA C3-cytosine methylation [GO:0106217]	arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; tRNA binding [GO:0000049]		GO:0000049; GO:0004814; GO:0005524; GO:0006420; GO:0106217
GN019457	GN019457.1	Q6P1C6	48.7	487	1225	1117	2.97e-109	373	LRIG3_MOUSE	Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3)	Mus musculus (Mouse)	otolith morphogenesis [GO:0032474]		cytoplasmic vesicle membrane [GO:0030659]; plasma membrane [GO:0005886]	GO:0005886; GO:0030659; GO:0032474
GN019458	GN019458.1	P81928	28.0	218	270	261	8.83e-12	67.0	TIDC1_DROME	Complex I assembly factor TIMMDC1, mitochondrial (RPII140-upstream gene protein) (Translocase of inner mitochondrial membrane domain-containing protein 1) (dTIMMDC1)	Drosophila melanogaster (Fruit fly)	mitochondrial respiratory chain complex I assembly [GO:0032981]		membrane [GO:0016020]; mitochondrion [GO:0005739]	GO:0005739; GO:0016020; GO:0032981
GN019461	GN019461.1	Q8CJ11	35.4	384	738	1013	1.57e-57	215	AGRG2_RAT	Adhesion G protein-coupled receptor G2 (G protein-coupled receptor 64) (Rat epididymis-specific protein 6) (Re6) [Cleaved into: Adhesion G protein-coupled receptor G2, N-terminal fragment (ADGRG2 N-terminal fragment); Adhesion G protein-coupled receptor G2, C-terminal fragment (ADGRG2 C-terminal fragment)]	Rattus norvegicus (Rat)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; spermatid development [GO:0007286]	G protein-coupled receptor activity [GO:0004930]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0007189; GO:0007200; GO:0007286; GO:0016324
GN019467	GN019467.1	Q8CDU4	28.9	700	819	790	7.49e-96	320	FXL13_MOUSE	F-box and leucine-rich repeat protein 13 (Dynein regulatory complex subunit 6) (F-box/LRR-repeat protein 13)	Mus musculus (Mouse)			centrosome [GO:0005813]	GO:0005813
GN019468	GN019468.1	Q04073	50.8	423	451	459	8.51e-115	347	P3A2_STRPU	DNA-binding protein P3A2	Strongylocentrotus purpuratus (Purple sea urchin)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357
GN019469	GN019469.1	C0HK24	37.4	99	213	103	1.03e-13	67.8	ELEL_ECHLU	L-rhamnose-binding lectin ELEL-1	Echinometra lucunter (Rock-boring urchin)		carbohydrate binding [GO:0030246]		GO:0030246
GN019470	GN019470.1	Q2KHU0	58.0	224	225	225	4.33e-94	277	SERB_BOVIN	Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserine phosphohydrolase)	Bos taurus (Bovine)	L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]	L-phosphoserine phosphatase activity [GO:0036424]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]	GO:0000287; GO:0005829; GO:0006563; GO:0006564; GO:0036424
GN019471	GN019471.1	Q9D0W5	78.5	93	99	166	6.45e-52	163	PPIL1_MOUSE	Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase PPIL1)	Mus musculus (Mouse)	embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]	disordered domain specific binding [GO:0097718]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; spliceosomal complex [GO:0005681]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000398; GO:0000413; GO:0003755; GO:0005634; GO:0005681; GO:0005730; GO:0006457; GO:0071006; GO:0071007; GO:0071013; GO:0071014; GO:0071020; GO:0097718; GO:1990403
GN019472	GN019472.1	Q5U374	30.4	247	1062	564	4.94e-27	120	KLH12_DANRE	Kelch-like protein 12	Danio rerio (Zebrafish) (Brachydanio rerio)	anterior/posterior pattern specification [GO:0009952]; convergent extension involved in axis elongation [GO:0060028]; COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; Wnt signaling pathway [GO:0016055]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]	GO:0005737; GO:0006513; GO:0006888; GO:0009952; GO:0014029; GO:0014032; GO:0016055; GO:0030127; GO:0030134; GO:0031463; GO:0043161; GO:0048208; GO:0060028; GO:1990756
GN019473	GN019473.1	Q5JXM2	29.1	179	521	366	1.38e-11	69.7	MET24_HUMAN	Probable methyltransferase-like protein 24 (EC 2.1.1.-)	Homo sapiens (Human)			extracellular region [GO:0005576]	GO:0005576
GN019475	GN019475.1	A2VD82	34.4	454	434	469	1.71e-84	269	TTC38_XENLA	Tetratricopeptide repeat protein 38 (TPR repeat protein 38)	Xenopus laevis (African clawed frog)				
GN019477	GN019477.1	O43301	33.9	546	511	675	1.10e-90	294	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN019479	GN019479.1	O75030	41.8	297	407	526	1.31e-45	167	MITF_HUMAN	Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32)	Homo sapiens (Human)	melanocyte differentiation [GO:0030318]; negative regulation of cell migration [GO:0030336]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of DNA-templated transcription initiation [GO:2000144]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of DNA-templated transcription [GO:0006355]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription by RNA polymerase II [GO:0006357]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; protein dimerization activity [GO:0046983]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000122; GO:0000785; GO:0000978; GO:0000981; GO:0001227; GO:0001228; GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0005765; GO:0005829; GO:0006355; GO:0006357; GO:0010628; GO:0030318; GO:0030336; GO:0032991; GO:0045893; GO:0045944; GO:0046983; GO:0065003; GO:0070888; GO:2000144; GO:2001141
GN019480	GN019480.1	H3BNL1	42.5	113	291	204	1.37e-22	95.9	CMIP7_HUMAN	Ciliary microtubule inner protein 7	Homo sapiens (Human)			cilium [GO:0005929]	GO:0005929
GN019484	GN019484.1	H2A0L0	32.7	336	680	492	1.92e-34	140	TYRO1_PINMG	Tyrosinase-like protein 1 (EC 1.14.18.-) (Tyrosinase 1)	Margaritifera margaritifera (Freshwater pearl mussel)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN019486	GN019486.1	P07825	41.6	202	246	307	4.28e-44	153	SYPH_RAT	Synaptophysin (Major synaptic vesicle protein p38)	Rattus norvegicus (Rat)	endocytosis [GO:0006897]; modulation of chemical synaptic transmission [GO:0050804]; protein homooligomerization [GO:0051260]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of opioid receptor signaling pathway [GO:2000474]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic vesicle priming [GO:0010807]; response to amyloid-beta [GO:1904645]	cholesterol binding [GO:0015485]; identical protein binding [GO:0042802]; protein carrier activity [GO:0140597]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; SH2 domain binding [GO:0042169]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]	basal part of cell [GO:0045178]; excitatory synapse [GO:0060076]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; neuron spine [GO:0044309]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; vestibular calyx terminal [GO:0099096]	GO:0000149; GO:0006897; GO:0008021; GO:0010807; GO:0014069; GO:0015485; GO:0016020; GO:0017075; GO:0019904; GO:0030672; GO:0031594; GO:0032991; GO:0042169; GO:0042734; GO:0042802; GO:0043005; GO:0043195; GO:0044306; GO:0044309; GO:0044877; GO:0045178; GO:0045202; GO:0048168; GO:0048169; GO:0048172; GO:0048471; GO:0048786; GO:0050804; GO:0051260; GO:0060076; GO:0098685; GO:0098793; GO:0099096; GO:0140597; GO:1904645; GO:2000474
GN019487	GN019487.1	Q9JJJ7	39.3	471	481	461	1.57e-106	327	PORCN_MOUSE	Protein-serine O-palmitoleoyltransferase porcupine (mPORC) (EC 2.3.1.250)	Mus musculus (Mouse)	glycoprotein metabolic process [GO:0009100]; lipid modification [GO:0030258]; protein lipidation [GO:0006497]; protein palmitoleylation [GO:0045234]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; Wnt protein secretion [GO:0061355]; Wnt signaling pathway [GO:0016055]	palmitoleoyltransferase activity [GO:1990698]; Wnt-protein binding [GO:0017147]	AMPA glutamate receptor complex [GO:0032281]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]	GO:0005783; GO:0005789; GO:0006497; GO:0009100; GO:0016020; GO:0016055; GO:0017147; GO:0030258; GO:0032281; GO:0045234; GO:0061355; GO:0098978; GO:0099072; GO:1990698
GN019488	GN019488.1	Q0VC03	32.4	389	397	450	1.33e-65	218	MFSD5_BOVIN	Solute carrier family 61 member 1 (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) (Molybdate-anion transporter)	Bos taurus (Bovine)		molybdate ion transmembrane transporter activity [GO:0015098]	plasma membrane [GO:0005886]	GO:0005886; GO:0015098
GN019489	GN019489.1	E9Q9F7	39.4	932	959	977	3.46e-181	553	CC146_MOUSE	Coiled-coil domain-containing protein 146	Mus musculus (Mouse)	cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; gene expression [GO:0010467]; manchette assembly [GO:1905198]; nucleus organization [GO:0006997]; single fertilization [GO:0007338]; sperm axoneme assembly [GO:0007288]; sperm flagellum assembly [GO:0120316]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]	protein-containing complex binding [GO:0044877]	axoneme [GO:0005930]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoskeleton [GO:0005856]; midbody [GO:0030496]; sperm flagellum [GO:0036126]; sperm head-tail coupling apparatus [GO:0120212]	GO:0000902; GO:0005813; GO:0005814; GO:0005856; GO:0005930; GO:0006997; GO:0007283; GO:0007286; GO:0007288; GO:0007338; GO:0008283; GO:0010467; GO:0030317; GO:0030496; GO:0036064; GO:0036126; GO:0044782; GO:0044877; GO:0120212; GO:0120316; GO:1905198
GN019490	GN019490.1	Q9Y265	87.7	456	456	456	6.88e-283	774	RUVB1_HUMAN	RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)	Homo sapiens (Human)	box C/D snoRNP assembly [GO:0000492]; chromatin remodeling [GO:0006338]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of telomere maintenance in response to DNA damage [GO:1904507]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of chromosome organization [GO:0033044]; regulation of DNA replication [GO:0006275]; regulation of DNA strand elongation [GO:0060382]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair [GO:2000779]; regulation of embryonic development [GO:0045995]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatogenesis [GO:0007283]; telomerase RNA localization to Cajal body [GO:0090671]; telomere maintenance [GO:0000723]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; DNA helicase activity [GO:0003678]; TBP-class protein binding [GO:0017025]; TFIID-class transcription factor complex binding [GO:0001094]; transcription coactivator activity [GO:0003713]	centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dynein axonemal particle [GO:0120293]; extracellular exosome [GO:0070062]; Ino80 complex [GO:0031011]; membrane [GO:0016020]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; R2TP complex [GO:0097255]; ribonucleoprotein complex [GO:1990904]; RPAP3/R2TP/prefoldin-like complex [GO:1990062]; Swr1 complex [GO:0000812]	GO:0000492; GO:0000723; GO:0000786; GO:0000812; GO:0001094; GO:0003678; GO:0003713; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0006275; GO:0006338; GO:0006355; GO:0006357; GO:0007283; GO:0016020; GO:0016363; GO:0016607; GO:0016887; GO:0017025; GO:0031011; GO:0033044; GO:0035267; GO:0036064; GO:0042981; GO:0043531; GO:0045296; GO:0045893; GO:0045995; GO:0050821; GO:0051117; GO:0051726; GO:0060382; GO:0070062; GO:0071339; GO:0090263; GO:0090671; GO:0097255; GO:0101031; GO:0120293; GO:1904507; GO:1905168; GO:1990062; GO:1990904; GO:2000779
GN019491	GN019491.1	Q2KHX4	89.1	476	476	476	1.65e-314	856	S61A2_BOVIN	Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2)	Bos taurus (Bovine)	post-translational protein targeting to membrane, translocation [GO:0031204]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]	ribosome binding [GO:0043022]; signal sequence binding [GO:0005048]; transmembrane protein transporter activity [GO:0008320]	endoplasmic reticulum membrane [GO:0005789]; Sec61 translocon complex [GO:0005784]	GO:0005048; GO:0005784; GO:0005789; GO:0006616; GO:0008320; GO:0031204; GO:0043022
GN019496	GN019496.1	Q8VC12	71.4	105	106	676	1.78e-46	160	HUTU_MOUSE	Urocanate hydratase (Urocanase) (EC 4.2.1.49) (Imidazolonepropionate hydrolase)	Mus musculus (Mouse)	L-histidine catabolic process [GO:0006548]	urocanate hydratase activity [GO:0016153]	cytosol [GO:0005829]	GO:0005829; GO:0006548; GO:0016153
GN019499	GN019499.1	Q4R6T7	53.1	638	975	790	4.87e-220	648	IQUB_MACFA	IQ motif and ubiquitin-like domain-containing protein	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; mating [GO:0007618]		9+2 motile cilium [GO:0097729]; acrosomal vesicle [GO:0001669]; radial spoke [GO:0001534]; sperm flagellum [GO:0036126]	GO:0001534; GO:0001669; GO:0007618; GO:0030317; GO:0036126; GO:0060271; GO:0097729
GN019500	GN019500.1	Q8WXX0	54.5	3928	4016	4024	0.0	4183	DYH7_HUMAN	Dynein axonemal heavy chain 7 (Axonemal beta dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (hDHC2)	Homo sapiens (Human)	cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; cilium-dependent cell motility [GO:0060285]; inner dynein arm assembly [GO:0036159]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; dynein intermediate chain binding [GO:0045505]; dynein light intermediate chain binding [GO:0051959]; microtubule motor activity [GO:0003777]; minus-end-directed microtubule motor activity [GO:0008569]	9+2 motile cilium [GO:0097729]; axonemal dynein complex [GO:0005858]; cilium [GO:0005929]; inner dynein arm [GO:0036156]; sperm annulus [GO:0097227]; sperm midpiece [GO:0097225]	GO:0003341; GO:0003777; GO:0005509; GO:0005524; GO:0005858; GO:0005929; GO:0008569; GO:0036156; GO:0036159; GO:0045505; GO:0051959; GO:0060285; GO:0060294; GO:0097225; GO:0097227; GO:0097729
GN019502	GN019502.1	P0C218	54.2	96	100	761	4.55e-28	109	DDX20_DANRE	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (DEAD box protein 20)	Danio rerio (Zebrafish) (Brachydanio rerio)	spliceosomal snRNP assembly [GO:0000387]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; RNA helicase activity [GO:0003724]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]	GO:0000387; GO:0003676; GO:0003724; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0016887; GO:0017111; GO:0032797; GO:0034719
GN019506	GN019506.1	P39944	23.2	534	702	805	5.43e-16	85.9	UBP5_YEAST	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	protein deubiquitination [GO:0016579]	cysteine-type deubiquitinase activity [GO:0004843]	cellular bud neck [GO:0005935]; incipient cellular bud site [GO:0000131]	GO:0000131; GO:0004843; GO:0005935; GO:0016579
GN019507	GN019507.1	Q14191	26.9	442	416	1432	5.23e-23	105	WRN_HUMAN	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Homo sapiens (Human)	base-excision repair [GO:0006284]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; cellular senescence [GO:0090398]; DNA damage response [GO:0006974]; DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; mismatch repair [GO:0006298]; positive regulation of strand invasion [GO:0098530]; protein localization to nucleolus [GO:1902570]; replication fork processing [GO:0031297]; response to UV-C [GO:0010225]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]; telomeric D-loop disassembly [GO:0061820]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; 3'-flap-structured DNA binding [GO:0070337]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; bubble DNA binding [GO:0000405]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; exonuclease activity [GO:0004527]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MutLalpha complex binding [GO:0032405]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]	centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]	GO:0000287; GO:0000400; GO:0000403; GO:0000405; GO:0000723; GO:0000731; GO:0000781; GO:0003677; GO:0003678; GO:0004527; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005694; GO:0005730; GO:0005737; GO:0005813; GO:0006259; GO:0006260; GO:0006284; GO:0006298; GO:0006302; GO:0006310; GO:0006974; GO:0008408; GO:0009267; GO:0009378; GO:0010225; GO:0016607; GO:0016887; GO:0030145; GO:0031297; GO:0032201; GO:0032392; GO:0032405; GO:0042803; GO:0043138; GO:0044877; GO:0051880; GO:0061749; GO:0061820; GO:0061821; GO:0061849; GO:0070337; GO:0071480; GO:0090398; GO:0090656; GO:0098530; GO:1902570; GO:1905773
GN019508	GN019508.1	Q5RE03	52.9	340	347	342	2.88e-112	333	PRP18_PONAB	Pre-mRNA-splicing factor 18 (PRP18 homolog)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	generation of catalytic spliceosome for second transesterification step [GO:0000350]		nuclear speck [GO:0016607]; U2-type post-spliceosomal complex [GO:0071021]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]	GO:0000350; GO:0005682; GO:0016607; GO:0046540; GO:0071021
GN019512	GN019512.1	Q9ULI1	26.0	1297	1731	1742	3.10e-81	301	NWD2_HUMAN	NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239)	Homo sapiens (Human)			synapse [GO:0045202]	GO:0045202
GN019513	GN019513.1	G5EF51	29.1	223	805	723	9.27e-17	88.6	KY_CAEEL	Lim and transglutaminase domain protein ltd-1 (Kyphoscoliosis inactive peptidase homolog ltd-1)	Caenorhabditis elegans	muscle structure development [GO:0061061]		cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; striated muscle dense body [GO:0055120]	GO:0005737; GO:0005856; GO:0005911; GO:0055120; GO:0061061
GN019514	GN019514.1	O54781	54.3	644	675	681	9.89e-187	548	SRPK2_MOUSE	SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]	Mus musculus (Mouse)	angiogenesis [GO:0001525]; intracellular signal transduction [GO:0035556]; negative regulation of viral genome replication [GO:0045071]; nuclear speck organization [GO:0035063]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0043491]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; R-loop processing [GO:0062176]; regulation of mRNA processing [GO:0050684]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]	14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	acrosomal vesicle [GO:0001669]; chromatin [GO:0000785]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; presynapse [GO:0098793]; sperm end piece [GO:0097229]	GO:0000245; GO:0000287; GO:0000785; GO:0001525; GO:0001669; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0005829; GO:0006468; GO:0008284; GO:0008380; GO:0010628; GO:0016607; GO:0018105; GO:0035063; GO:0035556; GO:0043491; GO:0043525; GO:0045070; GO:0045071; GO:0045787; GO:0050684; GO:0062176; GO:0071889; GO:0097229; GO:0098793; GO:0106310
GN019515	GN019515.1	Q0VG85	33.5	770	807	912	2.31e-116	377	CC162_MOUSE	Coiled-coil domain-containing protein 162	Mus musculus (Mouse)				
GN019520	GN019520.1	A0QZA1	29.4	143	145	294	4.60e-13	67.8	Y3950_MYCS2	Universal stress protein MSMEG_3950/MSMEI_3859 (USP MSMEG_3950)	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)				
GN019521	GN019521.1	Q9D826	49.5	384	382	390	2.94e-125	369	SOX_MOUSE	Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase)	Mus musculus (Mouse)	amino acid catabolic process [GO:0009063]; L-lysine catabolic process [GO:0019477]	flavin adenine dinucleotide binding [GO:0050660]; L-pipecolate oxidase activity [GO:0050031]; sarcosine oxidase activity [GO:0008115]	peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0005777; GO:0005782; GO:0008115; GO:0009063; GO:0019477; GO:0050031; GO:0050660
GN019522	GN019522.1	O35814	23.3	485	524	543	4.95e-13	75.1	STIP1_RAT	Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop)	Rattus norvegicus (Rat)	cellular response to interleukin-7 [GO:0098761]	Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein-folding chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; dynein axonemal particle [GO:0120293]; nucleus [GO:0005634]; protein folding chaperone complex [GO:0101031]; protein-containing complex [GO:0032991]	GO:0005634; GO:0005737; GO:0030544; GO:0032991; GO:0051087; GO:0051879; GO:0098761; GO:0101031; GO:0120293
GN019523	GN019523.1	P16580	76.8	203	234	373	3.43e-120	349	GLNA_CHICK	Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate decarboxylase) (EC 4.1.1.15) (Glutamate--ammonia ligase) (p42)	Gallus gallus (Chicken)		glutamate decarboxylase activity [GO:0004351]; glutamine synthetase activity [GO:0004356]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0004351; GO:0004356; GO:0005737; GO:0005739
GN019526	GN019526.1	Q3T0F5	87.4	207	205	207	2.78e-127	360	RAB7A_BOVIN	Ras-related protein Rab-7a (EC 3.6.5.2)	Bos taurus (Bovine)	early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; endosome to plasma membrane protein transport [GO:0099638]; lipophagy [GO:0061724]; phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]	GO:0000421; GO:0003924; GO:0003925; GO:0005525; GO:0005739; GO:0005764; GO:0005765; GO:0005770; GO:0005811; GO:0005829; GO:0008333; GO:0010008; GO:0030670; GO:0031410; GO:0031902; GO:0031966; GO:0033162; GO:0045022; GO:0045335; GO:0061724; GO:0090383; GO:0090385; GO:0099638
GN019527	GN019527.1	C4A0D9	74.3	269	278	694	3.15e-134	398	BAP1_BRAFL	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1)	Branchiostoma floridae (Florida lancelet) (Amphioxus)	heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromatin binding [GO:0003682]; cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; PR-DUB complex [GO:0035517]	GO:0001558; GO:0003682; GO:0004843; GO:0005634; GO:0005737; GO:0006511; GO:0016579; GO:0031507; GO:0035517; GO:0045892; GO:0051726; GO:0071108
GN019528	GN019528.1	C4A0D9	31.7	186	280	694	6.24e-09	60.1	BAP1_BRAFL	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1)	Branchiostoma floridae (Florida lancelet) (Amphioxus)	heterochromatin formation [GO:0031507]; negative regulation of DNA-templated transcription [GO:0045892]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromatin binding [GO:0003682]; cysteine-type deubiquitinase activity [GO:0004843]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; PR-DUB complex [GO:0035517]	GO:0001558; GO:0003682; GO:0004843; GO:0005634; GO:0005737; GO:0006511; GO:0016579; GO:0031507; GO:0035517; GO:0045892; GO:0051726; GO:0071108
GN019529	GN019529.1	Q3T0B2	74.8	274	304	389	1.98e-144	414	PSMD6_BOVIN	26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7)	Bos taurus (Bovine)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]		cytosol [GO:0005829]; proteasome accessory complex [GO:0022624]; proteasome regulatory particle [GO:0005838]	GO:0005829; GO:0005838; GO:0022624; GO:0043161
GN019530	GN019530.1	P02746	32.7	107	204	253	7.21e-09	57.4	C1QB_HUMAN	Complement C1q subcomponent subunit B	Homo sapiens (Human)	complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; synapse pruning [GO:0098883]	IgG binding [GO:0019864]; IgM binding [GO:0001791]; phosphatidylserine binding [GO:0001786]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; complement component C1 complex [GO:0005602]; complement component C1q complex [GO:0062167]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; postsynapse [GO:0098794]; symbiont cell surface [GO:0106139]; synapse [GO:0045202]	GO:0001786; GO:0001791; GO:0005576; GO:0005602; GO:0006956; GO:0006958; GO:0009986; GO:0019864; GO:0031012; GO:0045202; GO:0062167; GO:0072562; GO:0098794; GO:0098883; GO:0106139
GN019539	GN019539.1	Q9H2M3	34.3	332	349	363	2.49e-55	187	BHMT2_HUMAN	S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2)	Homo sapiens (Human)	L-methionine salvage [GO:0071267]; S-adenosylmethionine metabolic process [GO:0046500]; S-methylmethionine metabolic process [GO:0033477]	S-methylmethionine-homocysteine S-methyltransferase activity [GO:0061627]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0005829; GO:0008270; GO:0033477; GO:0046500; GO:0061627; GO:0070062; GO:0071267
GN019540	GN019540.1	Q57951	45.1	91	102	170	5.35e-12	61.6	Y531_METJA	Universal stress protein MJ0531 (USP MJ0531)	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)				
GN019541	GN019541.1	Q5XIA9	34.3	172	345	354	5.19e-19	90.1	KLD8B_RAT	Kelch domain-containing protein 8B	Rattus norvegicus (Rat)	mitotic cytokinetic process [GO:1902410]; mitotic nuclear division [GO:0140014]; nuclear chromosome segregation [GO:0098813]		cellularization cleavage furrow [GO:0110070]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; midbody [GO:0030496]	GO:0005737; GO:0005829; GO:0030496; GO:0045171; GO:0098813; GO:0110070; GO:0140014; GO:1902410
GN019547	GN019547.1	Q07E01	27.7	1421	1366	1382	2.45e-129	437	MET_ORNAN	Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)	Ornithorhynchus anatinus (Duckbill platypus)	cell development [GO:0048468]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; liver development [GO:0001889]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; regulation of gene expression [GO:0010468]; semaphorin-plexin signaling pathway [GO:0071526]	ATP binding [GO:0005524]; hepatocyte growth factor receptor activity [GO:0005008]; semaphorin receptor activity [GO:0017154]	basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001889; GO:0005008; GO:0005524; GO:0005886; GO:0007169; GO:0009925; GO:0010468; GO:0017154; GO:0030182; GO:0031016; GO:0043235; GO:0048468; GO:0050918; GO:0071526; GO:2001028
GN019549	GN019549.1	Q8VCK5	34.1	123	503	604	6.97e-14	77.8	KLH20_MOUSE	Kelch-like protein 20 (Kelch-like ECT2-interacting protein)	Mus musculus (Mouse)	Golgi to endosome transport [GO:0006895]; negative regulation of apoptotic process [GO:0043066]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K33-linked ubiquitination [GO:1990390]; protein ubiquitination [GO:0016567]	type II interferon binding [GO:0019964]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]	axon [GO:0030424]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; PML body [GO:0016605]; trans-Golgi network [GO:0005802]	GO:0004842; GO:0005737; GO:0005794; GO:0005802; GO:0005829; GO:0006895; GO:0016567; GO:0016605; GO:0019964; GO:0030424; GO:0030425; GO:0031463; GO:0043066; GO:0043161; GO:0048471; GO:1990390; GO:1990756
GN019551	GN019551.1	Q5ZKW0	48.9	403	396	424	6.23e-134	393	MTU1_CHICK	Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14)	Gallus gallus (Chicken)	mitochondrial tRNA wobble position uridine thiolation [GO:1990799]	tRNA-5-taurinomethyluridine 2-sulfurtransferase activity [GO:0061708]	mitochondrion [GO:0005739]	GO:0005739; GO:0061708; GO:1990799
GN019552	GN019552.1	Q704V6	31.2	138	151	793	1.75e-16	78.6	TLR6_BOVIN	Toll-like receptor 6 (CD antigen CD286)	Bos taurus (Bovine)	cellular response to diacyl bacterial lipopeptide [GO:0071726]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; toll-like receptor signaling pathway [GO:0002224]	identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]	Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]	GO:0002224; GO:0004888; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0030670; GO:0032731; GO:0035355; GO:0035663; GO:0038023; GO:0042802; GO:0045121; GO:0071723; GO:0071726; GO:1900227
GN019554	GN019554.1	P32297	33.3	117	142	505	6.79e-15	73.6	ACHA3_HUMAN	Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (Human)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; excitatory postsynaptic potential [GO:0060079]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; monoatomic ion transport [GO:0006811]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of acetylcholine secretion, neurotransmission [GO:0014056]; regulation of appetite [GO:0032098]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane potential [GO:0042391]; regulation of smooth muscle contraction [GO:0006940]; response to acetylcholine [GO:1905144]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission involved in micturition [GO:0060084]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; ligand-gated monoatomic ion channel activity [GO:0015276]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005783; GO:0005794; GO:0005886; GO:0005892; GO:0006811; GO:0006816; GO:0006940; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0007626; GO:0014056; GO:0015276; GO:0015464; GO:0016020; GO:0022848; GO:0030425; GO:0030594; GO:0032098; GO:0034220; GO:0035094; GO:0035095; GO:0042166; GO:0042391; GO:0042734; GO:0043005; GO:0043025; GO:0044853; GO:0045202; GO:0045211; GO:0048814; GO:0051899; GO:0060079; GO:0060084; GO:0095500; GO:0097060; GO:0099171; GO:1905144
GN019555	GN019555.1	F8WLE0	39.8	852	986	1034	1.47e-170	528	KIF28_RAT	Kinesin-like protein KIF28 (Kinesin family member 28) (Kinesin-like protein 6)	Rattus norvegicus (Rat)	mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384]; vesicle transport along microtubule [GO:0047496]	ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	kinesin complex [GO:0005871]; mitochondrial membrane [GO:0031966]	GO:0003777; GO:0005524; GO:0005871; GO:0007005; GO:0008017; GO:0031966; GO:0047496; GO:0072384
GN019556	GN019556.1	P30531	64.1	142	291	599	2.91e-62	209	SC6A1_HUMAN	Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)	Homo sapiens (Human)	amino acid transport [GO:0006865]; associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid reuptake [GO:0051936]; inorganic anion import across plasma membrane [GO:0098658]; memory [GO:0007613]; neurotransmitter transport [GO:0006836]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]; transport across blood-brain barrier [GO:0150104]	gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; sodium:chloride symporter activity [GO:0015378]	axon [GO:0030424]; cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynapse [GO:0098793]	GO:0005332; GO:0005886; GO:0006836; GO:0006865; GO:0007268; GO:0007613; GO:0008306; GO:0009986; GO:0015185; GO:0015378; GO:0016020; GO:0030424; GO:0035725; GO:0043025; GO:0050808; GO:0051936; GO:0051939; GO:0098658; GO:0098719; GO:0098793; GO:0098982; GO:0150104; GO:1902476
GN019557	GN019557.1	Q9N294	33.3	150	214	301	7.50e-24	99.4	B3GT5_PANPA	Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)	Pan paniscus (Pygmy chimpanzee) (Bonobo)	protein O-linked glycosylation [GO:0006493]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005783; GO:0006493; GO:0008499
GN019561	GN019561.1	Q96MM6	29.1	636	600	686	1.59e-71	246	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN019566	GN019566.1	Q9BV10	51.2	404	407	488	1.58e-142	417	ALG12_HUMAN	Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12 homolog) (hALG12) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Mannosyltransferase ALG12 homolog) (Membrane protein SB87)	Homo sapiens (Human)	dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein folding [GO:0006457]; protein N-linked glycosylation [GO:0006487]	alpha-1,6-mannosyltransferase activity [GO:0000009]; dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity [GO:0052917]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lumenal side of endoplasmic reticulum membrane [GO:0098553]; membrane [GO:0016020]	GO:0000009; GO:0000030; GO:0005783; GO:0005789; GO:0006457; GO:0006487; GO:0006488; GO:0016020; GO:0052917; GO:0098553
GN019567	GN019567.1	P33450	30.1	103	391	5147	7.77e-09	61.6	FAT_DROME	Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito]	Drosophila melanogaster (Fruit fly)	axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; equator specification [GO:0045317]; establishment of body hair planar orientation [GO:0048105]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of polarity of larval imaginal disc epithelium [GO:0016336]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; imaginal disc-derived wing morphogenesis [GO:0007476]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of growth [GO:0045926]; negative regulation of imaginal disc growth [GO:0045571]; negative regulation of organ growth [GO:0046621]; positive regulation of apoptotic process [GO:0043065]; positive regulation of hippo signaling [GO:0035332]; protein localization involved in establishment of planar polarity [GO:0090251]; pupal development [GO:0035209]; regulation of establishment of planar polarity [GO:0090175]; regulation of growth [GO:0040008]; regulation of imaginal disc growth [GO:0045570]; regulation of protein localization [GO:0032880]; regulation of tube length, open tracheal system [GO:0035159]; tissue development [GO:0009888]; wing disc development [GO:0035220]	cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0001736; GO:0001737; GO:0005509; GO:0005739; GO:0005886; GO:0005912; GO:0007156; GO:0007157; GO:0007164; GO:0007409; GO:0007446; GO:0007447; GO:0007476; GO:0008285; GO:0009888; GO:0010629; GO:0016324; GO:0016327; GO:0016336; GO:0016339; GO:0030855; GO:0032880; GO:0035159; GO:0035209; GO:0035220; GO:0035332; GO:0040008; GO:0042067; GO:0043065; GO:0044331; GO:0045296; GO:0045317; GO:0045570; GO:0045571; GO:0045926; GO:0046621; GO:0048105; GO:0090175; GO:0090176; GO:0090251; GO:0098609
GN019571	GN019571.1	Q6DDU9	50.0	62	63	749	2.04e-16	74.3	RBM5B_XENLA	RNA-binding protein 5-B (RNA-binding motif protein 5-B)	Xenopus laevis (African clawed frog)	positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; spliceosomal complex assembly [GO:0000245]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nucleus [GO:0005634]	GO:0000245; GO:0000381; GO:0003723; GO:0003729; GO:0005634; GO:0043065
GN019572	GN019572.1	B2GV05	24.8	472	506	815	1.24e-14	80.5	RBM5_RAT	RNA-binding protein 5 (RNA-binding motif protein 5)	Rattus norvegicus (Rat)	positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; spliceosomal complex assembly [GO:0000245]	mRNA binding [GO:0003729]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000245; GO:0000381; GO:0003723; GO:0003729; GO:0005634; GO:0005654; GO:0043065
GN019576	GN019576.1	D3YZI9	32.2	121	251	523	6.73e-09	59.3	PGBD5_MOUSE	PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac transposase 5)	Mus musculus (Mouse)	non-replicative DNA transposition [GO:0098038]	transposase activity [GO:0004803]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004803; GO:0005634; GO:0005654; GO:0098038
GN019577	GN019577.1	Q9R0M0	32.3	758	750	2919	2.90e-85	299	CELR2_MOUSE	Cadherin EGF LAG seven-pass G-type receptor 2 (Flamingo homolog)	Mus musculus (Mouse)	axonogenesis [GO:0007409]; cell-cell adhesion mediated by cadherin [GO:0044331]; cerebrospinal fluid secretion [GO:0033326]; cilium assembly [GO:0060271]; cilium movement [GO:0003341]; dendrite morphogenesis [GO:0048813]; homophilic cell-cell adhesion [GO:0007156]; neural plate anterior/posterior regionalization [GO:0021999]; neuron migration [GO:0001764]; regulation of cell-cell adhesion [GO:0022407]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein localization [GO:0032880]; ventricular system development [GO:0021591]; Wnt signaling pathway [GO:0016055]	calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]	adherens junction [GO:0005912]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0001764; GO:0003341; GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0005912; GO:0006355; GO:0007156; GO:0007409; GO:0016055; GO:0021591; GO:0021999; GO:0022407; GO:0032880; GO:0033326; GO:0044331; GO:0048813; GO:0060271
GN019579	GN019579.1	O89049	65.0	300	310	499	8.27e-134	392	TRXR1_RAT	Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (NADPH-dependent thioredoxin reductase) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1)	Rattus norvegicus (Rat)	benzene-containing compound metabolic process [GO:0042537]; cell population proliferation [GO:0008283]; cell redox homeostasis [GO:0045454]; cellular response to copper ion [GO:0071280]; cellular response to hyperoxia [GO:0071455]; gastrulation [GO:0007369]; halogen metabolic process [GO:0070276]; hydrogen peroxide catabolic process [GO:0042744]; mesoderm formation [GO:0001707]; positive regulation of apoptotic process [GO:0043065]; response to axon injury [GO:0048678]; response to hyperoxia [GO:0055093]; response to oxidative stress [GO:0006979]; response to selenium ion [GO:0010269]; response to xenobiotic stimulus [GO:0009410]	FAD binding [GO:0071949]; identical protein binding [GO:0042802]; mercury ion binding [GO:0045340]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADPH peroxidase activity [GO:0050137]; selenate reductase activity [GO:0033797]; thioredoxin-disulfide reductase (NADPH) activity [GO:0004791]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001707; GO:0004791; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0006979; GO:0007369; GO:0008283; GO:0009410; GO:0010269; GO:0016174; GO:0033797; GO:0042537; GO:0042744; GO:0042802; GO:0043025; GO:0043065; GO:0045340; GO:0045454; GO:0048678; GO:0050137; GO:0055093; GO:0070276; GO:0071280; GO:0071455; GO:0071949
GN019580	GN019580.1	Q16881	69.6	112	130	649	1.87e-45	159	TRXR1_HUMAN	Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1)	Homo sapiens (Human)	cell redox homeostasis [GO:0045454]; selenium compound metabolic process [GO:0001887]; signal transduction [GO:0007165]	FAD binding [GO:0071949]; identical protein binding [GO:0042802]; methylseleninic acid reductase activity [GO:0098626]; methylselenol reductase activity [GO:0098625]; NADPH peroxidase activity [GO:0050137]; thioredoxin-disulfide reductase (NADPH) activity [GO:0004791]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; thioredoxin-disulfide reductase complex [GO:1902515]	GO:0001887; GO:0004791; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0007165; GO:0042802; GO:0045454; GO:0050137; GO:0070062; GO:0071949; GO:0098625; GO:0098626; GO:1902515
GN019581	GN019581.1	Q8MPM1	50.9	342	346	366	2.50e-116	344	GELS2_LUMTE	Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2)	Lumbricus terrestris (Common earthworm)	actin polymerization or depolymerization [GO:0008154]	actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]	GO:0005737; GO:0008154; GO:0015629; GO:0051015
GN019584	GN019584.1	P42700	28.8	468	483	538	6.86e-41	157	RO60_XENLA	RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2)	Xenopus laevis (African clawed frog)		misfolded RNA binding [GO:0034336]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; ribonucleoprotein complex [GO:1990904]	GO:0003723; GO:0005737; GO:0034336; GO:1990904
GN019587	GN019587.1	Q6ZUG5	43.6	172	760	572	6.79e-42	164	YC006_HUMAN	Uncharacterized protein FLJ43738	Homo sapiens (Human)				
GN019588	GN019588.1	Q58CN9	48.6	210	222	392	5.12e-62	201	NAPEP_BOVIN	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54)	Bos taurus (Bovine)	host-mediated modulation of intestinal microbiota composition [GO:0048874]; N-acylethanolamine metabolic process [GO:0070291]; N-acylphosphatidylethanolamine metabolic process [GO:0070292]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of inflammatory response [GO:0050729]; temperature homeostasis [GO:0001659]	N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]	GO:0000139; GO:0001659; GO:0005635; GO:0005654; GO:0005737; GO:0005769; GO:0005794; GO:0008270; GO:0031901; GO:0043005; GO:0043025; GO:0048874; GO:0050729; GO:0070290; GO:0070291; GO:0070292; GO:0090336
GN019590	GN019590.1	Q16829	49.0	339	345	419	7.37e-102	309	DUS7_HUMAN	Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2)	Homo sapiens (Human)	ERK1 and ERK2 cascade [GO:0070371]; MAPK cascade [GO:0000165]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAP kinase activity [GO:0043407]; peptidyl-tyrosine dephosphorylation [GO:0035335]	MAP kinase tyrosine phosphatase activity [GO:0033550]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine/threonine phosphatase activity [GO:0008330]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0000165; GO:0004722; GO:0004725; GO:0005654; GO:0005737; GO:0005829; GO:0008138; GO:0008330; GO:0017017; GO:0033550; GO:0035335; GO:0043407; GO:0070371; GO:0070373
GN019591	GN019591.1	Q69Z37	23.0	418	1612	1561	8.97e-10	67.8	SAM9L_MOUSE	Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like)	Mus musculus (Mouse)	common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145]		cytoplasm [GO:0005737]; early endosome [GO:0005769]; mitochondrion [GO:0005739]	GO:0002244; GO:0005737; GO:0005739; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536
GN019595	GN019595.1	Q7ZY86	39.6	154	154	700	1.04e-36	136	TM168_XENLA	Transmembrane protein 168	Xenopus laevis (African clawed frog)		sodium channel regulator activity [GO:0017080]	nuclear membrane [GO:0031965]	GO:0017080; GO:0031965
GN019596	GN019596.1	Q91VX9	31.6	152	179	697	1.16e-18	85.9	TM168_MOUSE	Transmembrane protein 168	Mus musculus (Mouse)	regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; regulation of voltage-gated sodium channel activity [GO:1905150]	sodium channel regulator activity [GO:0017080]	nuclear membrane [GO:0031965]; transport vesicle [GO:0030133]	GO:0017080; GO:0030133; GO:0031965; GO:1905150; GO:2000058
GN019604	GN019604.1	Q9H8W5	23.4	333	311	580	2.38e-12	70.9	TRI45_HUMAN	E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99)	Homo sapiens (Human)	negative regulation of inflammatory response [GO:0050728]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005737; GO:0005829; GO:0008270; GO:0043161; GO:0050728; GO:0061630; GO:0070936
GN019606	GN019606.1	Q9ESN6	30.5	151	366	744	3.78e-12	71.2	TRIM2_MOUSE	Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) (RING-type E3 ubiquitin transferase TRIM2)	Mus musculus (Mouse)	cellular response to leukemia inhibitory factor [GO:1990830]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]	myosin binding [GO:0017022]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0017022; GO:0043161; GO:0043523; GO:0061630; GO:1990830
GN019607	GN019607.1	B3EWZ5	42.2	83	81	5145	1.87e-14	69.7	MLRP1_ACRMI	MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN019608	GN019608.1	B3EWZ6	47.6	82	81	7311	2.88e-15	72.0	MLRP2_ACRMI	MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2)	Acropora millepora (Staghorn coral) (Heteropora millepora)			extracellular region [GO:0005576]; membrane [GO:0016020]	GO:0005576; GO:0016020
GN019618	GN019618.1	Q08C76	40.3	355	370	361	3.82e-47	167	SSUH2_DANRE	Protein SSUH2 homolog (Protein ssu-2 homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	odontogenesis [GO:0042476]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0042476
GN019619	GN019619.1	A2BIR6	37.5	320	299	313	1.32e-66	213	YDJC_DANRE	Carbohydrate deacetylase (EC 3.5.1.-)	Danio rerio (Zebrafish) (Brachydanio rerio)	carbohydrate metabolic process [GO:0005975]	deacetylase activity [GO:0019213]; magnesium ion binding [GO:0000287]		GO:0000287; GO:0005975; GO:0019213
GN019624	GN019624.1	Q2M389	61.0	392	396	1173	1.89e-167	502	WASC4_HUMAN	WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP)	Homo sapiens (Human)	endosomal transport [GO:0016197]; endosome organization [GO:0007032]; nuclear envelope budding [GO:0140591]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]		early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203]	GO:0005654; GO:0005768; GO:0005769; GO:0007032; GO:0016197; GO:0031901; GO:0034315; GO:0071203; GO:0140591
GN019626	GN019626.1	Q9UP83	60.2	805	807	860	0.0	932	COG5_HUMAN	Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1)	Homo sapiens (Human)	Golgi organization [GO:0007030]; inter-Golgi cisterna vesicle-mediated transport [GO:0048219]; intra-Golgi vesicle-mediated transport [GO:0006891]; retrograde transport, vesicle recycling within Golgi [GO:0000301]		COG complex [GO:0017119]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network membrane [GO:0032588]	GO:0000139; GO:0000301; GO:0005794; GO:0005829; GO:0006891; GO:0007030; GO:0016020; GO:0017119; GO:0032588; GO:0048219
GN019627	GN019627.1	O95620	57.4	216	235	317	7.53e-87	263	DUS4L_HUMAN	tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (EC 1.3.1.90) (pp35) (tRNA-dihydrouridine synthase 4-like)	Homo sapiens (Human)	tRNA dihydrouridine synthesis [GO:0002943]	flavin adenine dinucleotide binding [GO:0050660]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine20a synthase activity [GO:0102266]; tRNA-dihydrouridine20b synthase activity [GO:0102267]		GO:0002943; GO:0017150; GO:0050660; GO:0102266; GO:0102267
GN019628	GN019628.1	Q9BYP7	68.8	368	2083	1800	1.26e-141	490	WNK3_HUMAN	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3)	Homo sapiens (Human)	cell volume homeostasis [GO:0006884]; cellular hyperosmotic response [GO:0071474]; DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; maintenance of blood-brain barrier [GO:0035633]; membraneless organelle assembly [GO:0140694]; monoatomic ion homeostasis [GO:0050801]; negative regulation of apoptotic process [GO:0043066]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of protein localization to plasma membrane [GO:1903077]; osmosensory signaling pathway [GO:0007231]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of calcium ion import [GO:0090279]; regulation of monoatomic cation transmembrane transport [GO:1904062]; renal sodium ion absorption [GO:0070294]	ATP binding [GO:0005524]; molecular condensate scaffold activity [GO:0140693]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transmembrane transporter binding [GO:0044325]; transporter activator activity [GO:0141109]	adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0005912; GO:0005923; GO:0006468; GO:0006884; GO:0006974; GO:0007231; GO:0010765; GO:0010800; GO:0035556; GO:0035633; GO:0043066; GO:0044325; GO:0050801; GO:0051928; GO:0070294; GO:0071474; GO:0072659; GO:0090188; GO:0090263; GO:0090279; GO:0106310; GO:0140693; GO:0140694; GO:0141109; GO:1903077; GO:1903078; GO:1904062; GO:2000651
GN019630	GN019630.1	Q6DIH3	63.3	120	124	884	6.44e-33	124	MCM2_XENTR	DNA replication licensing factor mcm2 (EC 3.6.4.12) (Minichromosome maintenance protein 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cell cycle DNA replication [GO:0044786]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; chromosome [GO:0005694]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; nucleus [GO:0005634]	GO:0000727; GO:0000785; GO:0003678; GO:0003697; GO:0005524; GO:0005634; GO:0005694; GO:0016887; GO:0030174; GO:0042555; GO:0044786; GO:0071162; GO:1902975
GN019631	GN019631.1	B2IZD3	29.8	141	1027	693	7.47e-09	63.5	BDLP_NOSP7	Bacterial dynamin-like protein (BDLP) (EC 3.6.5.5)	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	mitochondrial fusion [GO:0008053]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]	plasma membrane [GO:0005886]	GO:0003924; GO:0005525; GO:0005886; GO:0008053; GO:0008289; GO:0042802
GN019632	GN019632.1	Q9HCJ2	27.1	166	407	640	3.52e-10	65.5	LRC4C_HUMAN	Leucine-rich repeat-containing protein 4C (Netrin-G1 ligand) (NGL-1)	Homo sapiens (Human)	modulation of chemical synaptic transmission [GO:0050804]; regulation of axonogenesis [GO:0050770]; synaptic membrane adhesion [GO:0099560]	cell adhesion molecule binding [GO:0050839]; cell-cell adhesion mediator activity [GO:0098632]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0005576; GO:0005886; GO:0016020; GO:0050770; GO:0050804; GO:0050839; GO:0098632; GO:0098685; GO:0098839; GO:0098978; GO:0099560
GN019634	GN019634.1	P20695	49.6	375	433	449	3.65e-103	317	IFRD1_RAT	Interferon-related developmental regulator 1 (IRPR) (Nerve growth factor-inducible protein PC4)	Rattus norvegicus (Rat)	adipose tissue development [GO:0060612]; fat cell differentiation [GO:0045444]; glial cell proliferation [GO:0014009]; muscle cell differentiation [GO:0042692]; negative regulation of axon extension [GO:0030517]; negative regulation of collateral sprouting [GO:0048671]; neuroblast proliferation [GO:0007405]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; skeletal muscle tissue regeneration [GO:0043403]; striated muscle tissue development [GO:0014706]; Wnt signaling pathway [GO:0016055]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0001228; GO:0005634; GO:0005737; GO:0005886; GO:0006357; GO:0007405; GO:0014009; GO:0014706; GO:0016055; GO:0030517; GO:0042692; GO:0043403; GO:0045444; GO:0045944; GO:0048671; GO:0060612; GO:0061629
GN019635	GN019635.1	M9PH32	27.2	206	522	1206	1.49e-13	77.4	MEI26_DROME	Protein meiotic P26	Drosophila melanogaster (Fruit fly)	protein ubiquitination [GO:0016567]	ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]	GO:0004842; GO:0005737; GO:0008270; GO:0016567; GO:0036464
GN019637	GN019637.1	Q2QLA9	29.3	1358	1363	1381	1.59e-140	468	MET_HORSE	Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)	Equus caballus (Horse)	cell development [GO:0048468]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; liver development [GO:0001889]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; regulation of gene expression [GO:0010468]; semaphorin-plexin signaling pathway [GO:0071526]	ATP binding [GO:0005524]; hepatocyte growth factor receptor activity [GO:0005008]; semaphorin receptor activity [GO:0017154]	basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001889; GO:0005008; GO:0005524; GO:0005886; GO:0007169; GO:0009925; GO:0010468; GO:0017154; GO:0030182; GO:0031016; GO:0043235; GO:0048468; GO:0050918; GO:0071526; GO:2001028
GN019639	GN019639.1	Q80UN1	35.4	99	342	339	9.32e-09	59.7	KCTD9_MOUSE	BTB/POZ domain-containing protein KCTD9	Mus musculus (Mouse)	cell maturation [GO:0048469]; gene expression [GO:0010467]; intracellular signal transduction [GO:0035556]; natural killer cell degranulation [GO:0043320]; natural killer cell differentiation [GO:0001779]; natural killer cell proliferation [GO:0001787]; NK T cell lineage commitment [GO:0002364]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; response to tumor cell [GO:0002347]; response to virus [GO:0009615]	cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]		GO:0001779; GO:0001787; GO:0002347; GO:0002364; GO:0009615; GO:0010467; GO:0016567; GO:0035556; GO:0042802; GO:0043320; GO:0048469; GO:0051260; GO:0097602
GN019641	GN019641.1	Q2QLE0	29.9	793	838	1381	1.85e-73	266	MET_PIG	Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)	Sus scrofa (Pig)	branching morphogenesis of an epithelial tube [GO:0048754]; cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; endothelial cell morphogenesis [GO:0001886]; liver development [GO:0001889]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; neuron differentiation [GO:0030182]; pancreas development [GO:0031016]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of transcription by RNA polymerase II [GO:0045944]; semaphorin-plexin signaling pathway [GO:0071526]	ATP binding [GO:0005524]; hepatocyte growth factor receptor activity [GO:0005008]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]; semaphorin receptor activity [GO:0017154]	basal plasma membrane [GO:0009925]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001886; GO:0001889; GO:0005008; GO:0005524; GO:0005886; GO:0007169; GO:0009925; GO:0017154; GO:0019903; GO:0030182; GO:0031016; GO:0042802; GO:0043235; GO:0045944; GO:0048754; GO:0050918; GO:0071526; GO:1901299; GO:2001028
GN019646	GN019646.1	A7Y2X0	50.7	586	814	790	5.85e-204	601	SC6A5_XENLA	Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (xGlyT2) (Solute carrier family 6 member 5)	Xenopus laevis (African clawed frog)	glycine import across plasma membrane [GO:1903804]; sodium ion transmembrane transport [GO:0035725]; synaptic transmission, glycinergic [GO:0060012]	glycine:sodium symporter activity [GO:0015375]	plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0005886; GO:0015375; GO:0035725; GO:0045202; GO:0060012; GO:1903804
GN019647	GN019647.1	Q761V0	49.4	585	707	799	1.27e-198	583	SC6A5_MOUSE	Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5)	Mus musculus (Mouse)	glycine import across plasma membrane [GO:1903804]; glycine transport [GO:0015816]; neurotransmitter reuptake [GO:0098810]; neurotransmitter uptake [GO:0001504]; sodium ion transmembrane transport [GO:0035725]; synaptic transmission, glycinergic [GO:0060012]	glycine transmembrane transporter activity [GO:0015187]; glycine:sodium symporter activity [GO:0015375]	dense core granule [GO:0031045]; endosome [GO:0005768]; glycinergic synapse [GO:0098690]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]	GO:0001504; GO:0005768; GO:0005886; GO:0015187; GO:0015375; GO:0015816; GO:0031045; GO:0035725; GO:0042734; GO:0060012; GO:0098690; GO:0098810; GO:1903804
GN019650	GN019650.1	Q9XWB9	35.8	120	253	320	2.54e-15	77.4	BAT36_CAEEL	BTB and MATH domain-containing protein 36	Caenorhabditis elegans				
GN019651	GN019651.1	P09484	30.5	302	409	491	1.05e-42	159	ACHB2_CHICK	Neuronal acetylcholine receptor subunit beta-2 (Neuronal acetylcholine receptor non-alpha-1 chain) (N-alpha 1)	Gallus gallus (Chicken)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; memory [GO:0007613]; monoatomic ion transmembrane transport [GO:0034220]; response to hypoxia [GO:0001666]; synaptic transmission, cholinergic [GO:0007271]; visual learning [GO:0008542]	acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0001666; GO:0005737; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007613; GO:0008542; GO:0015464; GO:0022848; GO:0030424; GO:0030425; GO:0034220; GO:0035095; GO:0042166; GO:0043005; GO:0043204; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060
GN019652	GN019652.1	O70212	31.4	172	158	490	3.89e-19	86.3	5HT3A_CAVPO	5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor)	Cavia porcellus (Guinea pig)	monoatomic cation transport [GO:0006812]	extracellular ligand-gated monoatomic ion channel activity [GO:0005230]; GABA-A receptor activity [GO:0004890]	plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synaptic vesicle membrane [GO:0030672]	GO:0004890; GO:0005230; GO:0005886; GO:0006812; GO:0030672; GO:0045211
GN019655	GN019655.1	Q14517	41.7	120	133	4588	5.38e-19	85.1	FAT1_HUMAN	Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]	Homo sapiens (Human)	anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; homophilic cell-cell adhesion [GO:0007156]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0005509; GO:0005634; GO:0005829; GO:0005886; GO:0005911; GO:0005912; GO:0005925; GO:0007155; GO:0007156; GO:0007267; GO:0009653; GO:0016477; GO:0044331; GO:0048471; GO:0070062; GO:1904385; GO:1904754
GN019657	GN019657.1	Q2PZL6	32.6	476	619	4981	5.84e-61	224	FAT4_MOUSE	Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J)	Mus musculus (Mouse)	axonogenesis [GO:0007409]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell adhesion mediated by cadherin [GO:0044331]; cerebral cortex development [GO:0021987]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; epithelial cell differentiation [GO:0030855]; establishment of planar polarity [GO:0001736]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell-cell adhesion [GO:0007156]; inner ear receptor cell stereocilium organization [GO:0060122]; kidney development [GO:0001822]; nephron development [GO:0072006]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; apical part of cell [GO:0045177]; plasma membrane [GO:0005886]	GO:0001658; GO:0001736; GO:0001822; GO:0003007; GO:0005509; GO:0005886; GO:0005912; GO:0007009; GO:0007156; GO:0007157; GO:0007219; GO:0007409; GO:0008543; GO:0021987; GO:0022008; GO:0030855; GO:0035329; GO:0043931; GO:0044331; GO:0045177; GO:0048565; GO:0060122; GO:0072006; GO:0072137; GO:0072307
GN019658	GN019658.1	Q9V5N8	36.7	286	307	3579	3.46e-35	138	STAN_DROME	Protocadherin-like wing polarity protein stan (Protein flamingo) (Protein starry night)	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion [GO:0016339]; cell surface receptor signaling pathway [GO:0007166]; cell-cell adhesion mediated by cadherin [GO:0044331]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; homophilic cell-cell adhesion [GO:0007156]; morphogenesis of a polarized epithelium [GO:0001738]; mushroom body development [GO:0016319]; ommatidial rotation [GO:0016318]; positive regulation of axon extension [GO:0045773]; positive regulation of axon guidance [GO:1902669]; R3/R4 development [GO:0048057]; regulation of axonogenesis [GO:0050770]; regulation of synapse assembly [GO:0051963]; regulation of tube length, open tracheal system [GO:0035159]; segment polarity determination [GO:0007367]	calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]; G protein-coupled receptor activity [GO:0004930]; transmembrane signaling receptor activity [GO:0004888]	adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001736; GO:0001737; GO:0001738; GO:0004888; GO:0004930; GO:0005509; GO:0005886; GO:0005911; GO:0005912; GO:0007156; GO:0007166; GO:0007367; GO:0007409; GO:0007411; GO:0016020; GO:0016318; GO:0016319; GO:0016324; GO:0016339; GO:0016358; GO:0035159; GO:0042067; GO:0044331; GO:0045773; GO:0048057; GO:0048813; GO:0050770; GO:0050839; GO:0051963; GO:0070593; GO:1902669
GN019659	GN019659.1	Q14517	38.4	164	236	4588	8.41e-21	94.4	FAT1_HUMAN	Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]	Homo sapiens (Human)	anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; homophilic cell-cell adhesion [GO:0007156]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0005509; GO:0005634; GO:0005829; GO:0005886; GO:0005911; GO:0005912; GO:0005925; GO:0007155; GO:0007156; GO:0007267; GO:0009653; GO:0016477; GO:0044331; GO:0048471; GO:0070062; GO:1904385; GO:1904754
GN019663	GN019663.1	Q3MHH4	60.5	86	85	775	1.83e-28	109	SYQ_BOVIN	Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS)	Bos taurus (Bovine)	brain development [GO:0007420]; glutaminyl-tRNA aminoacylation [GO:0006425]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stress-activated MAPK cascade [GO:0032873]	ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004819; GO:0004860; GO:0005524; GO:0005737; GO:0005829; GO:0006425; GO:0007420; GO:0017101; GO:0019901; GO:0032873; GO:0045892; GO:2001234
GN019664	GN019664.1	Q3MHH4	83.2	137	162	775	1.70e-79	253	SYQ_BOVIN	Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS)	Bos taurus (Bovine)	brain development [GO:0007420]; glutaminyl-tRNA aminoacylation [GO:0006425]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stress-activated MAPK cascade [GO:0032873]	ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004819; GO:0004860; GO:0005524; GO:0005737; GO:0005829; GO:0006425; GO:0007420; GO:0017101; GO:0019901; GO:0032873; GO:0045892; GO:2001234
GN019665	GN019665.1	P47897	54.1	196	211	775	2.28e-56	193	SYQ_HUMAN	Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS)	Homo sapiens (Human)	brain development [GO:0007420]; glutaminyl-tRNA aminoacylation [GO:0006425]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of stress-activated MAPK cascade [GO:0032873]; tRNA aminoacylation for protein translation [GO:0006418]	ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; protein-containing complex [GO:0032991]	GO:0004819; GO:0004860; GO:0005524; GO:0005737; GO:0005759; GO:0005829; GO:0006418; GO:0006425; GO:0007420; GO:0017101; GO:0019901; GO:0032873; GO:0032991; GO:0045892; GO:2001234
GN019667	GN019667.1	Q3U2S4	53.3	413	514	566	7.82e-126	382	OTUD5_MOUSE	OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)	Mus musculus (Mouse)	CD8-positive, alpha-beta T cell differentiation [GO:0043374]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of interleukin-17 production [GO:0032700]; neural crest cell differentiation [GO:0014033]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TORC2 signaling [GO:1904515]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of immune response [GO:0050776]; regulation of protein stability [GO:0031647]; regulation of T-helper 17 type immune response [GO:2000316]; response to lipopolysaccharide [GO:0032496]; T-helper 17 cell lineage commitment [GO:0072540]	cysteine-type deubiquitinase activity [GO:0004843]; deubiquitinase activity [GO:0101005]; K48-linked deubiquitinase activity [GO:1990380]; K63-linked deubiquitinase activity [GO:0061578]	nucleus [GO:0005634]	GO:0004843; GO:0005634; GO:0014033; GO:0016579; GO:0031647; GO:0032496; GO:0032700; GO:0043161; GO:0043374; GO:0050776; GO:0061578; GO:0070536; GO:0071108; GO:0072540; GO:0090090; GO:0101005; GO:1904263; GO:1904515; GO:1990380; GO:2000316
GN019676	GN019676.1	Q61124	46.1	384	386	438	1.57e-97	300	CLN3_MOUSE	Battenin (Protein CLN3)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; action potential [GO:0001508]; amino acid transport [GO:0006865]; amyloid precursor protein catabolic process [GO:0042987]; associative learning [GO:0008306]; autophagosome maturation [GO:0097352]; autophagosome-lysosome fusion [GO:0061909]; cell migration [GO:0016477]; endocytosis [GO:0006897]; glycerophospholipid biosynthetic process [GO:0046474]; glycolipid transport [GO:0046836]; Golgi to lysosome transport [GO:0090160]; intracellular water homeostasis [GO:0009992]; ionotropic glutamate receptor signaling pathway [GO:0035235]; L-arginine transmembrane transport [GO:1903826]; learning or memory [GO:0007611]; lysosomal lumen acidification [GO:0007042]; lysosomal lumen pH elevation [GO:0035752]; lysosomal protein catabolic process [GO:1905146]; lysosome organization [GO:0007040]; macroautophagy [GO:0016236]; membrane organization [GO:0061024]; negative regulation of apoptotic process [GO:0043066]; negative regulation of catalytic activity [GO:0043086]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of proteolysis [GO:0045861]; neuromuscular process controlling balance [GO:0050885]; phagosome-lysosome docking [GO:0090384]; phagosome-lysosome fusion [GO:0090385]; plasma membrane raft organization [GO:0044857]; positive regulation of caveolin-mediated endocytosis [GO:2001288]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of pinocytosis [GO:0048549]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to membrane [GO:0072657]; protein localization to plasma membrane [GO:0072659]; protein processing [GO:0016485]; receptor-mediated endocytosis [GO:0006898]; regulation of arginine biosynthetic process [GO:1900079]; regulation of autophagosome maturation [GO:1901096]; regulation of autophagosome size [GO:0016243]; regulation of autophagy [GO:0010506]; regulation of cellular response to osmotic stress [GO:0106049]; regulation of cytoskeleton organization [GO:0051493]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of fibroblast migration [GO:0010762]; regulation of filopodium assembly [GO:0051489]; regulation of gene expression [GO:0010468]; regulation of modification of synaptic structure [GO:1905244]; regulation of phagosome maturation [GO:1905162]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of protein processing [GO:0070613]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic transmission, GABAergic [GO:0032228]; regulation of synaptic transmission, glutamatergic [GO:0051966]; renal potassium excretion [GO:0036359]; vesicle transport along microtubule [GO:0047496]	calcium-dependent protein binding [GO:0048306]; glycolipid binding [GO:0051861]; sulfatide binding [GO:0120146]	autolysosome [GO:0044754]; autophagosome [GO:0005776]; caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0001508; GO:0001934; GO:0005634; GO:0005737; GO:0005764; GO:0005765; GO:0005768; GO:0005769; GO:0005770; GO:0005776; GO:0005783; GO:0005789; GO:0005794; GO:0005795; GO:0005802; GO:0005829; GO:0005886; GO:0005901; GO:0006865; GO:0006897; GO:0006898; GO:0007040; GO:0007042; GO:0007611; GO:0008021; GO:0008306; GO:0009992; GO:0010468; GO:0010506; GO:0010762; GO:0016020; GO:0016236; GO:0016243; GO:0016477; GO:0016485; GO:0030036; GO:0031410; GO:0031901; GO:0031902; GO:0032228; GO:0035235; GO:0035752; GO:0036359; GO:0042987; GO:0042998; GO:0043005; GO:0043066; GO:0043086; GO:0043524; GO:0044754; GO:0044857; GO:0045121; GO:0045861; GO:0046474; GO:0046836; GO:0047496; GO:0048172; GO:0048306; GO:0048549; GO:0050885; GO:0051480; GO:0051489; GO:0051493; GO:0051861; GO:0051966; GO:0055037; GO:0061024; GO:0061909; GO:0070613; GO:0072657; GO:0072659; GO:0090160; GO:0090384; GO:0090385; GO:0097352; GO:0106049; GO:0120146; GO:1900079; GO:1901096; GO:1903076; GO:1903826; GO:1905146; GO:1905162; GO:1905244; GO:2001288
GN019677	GN019677.1	Q9NUV9	42.2	218	433	329	1.07e-47	169	GIMA4_HUMAN	GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4)	Homo sapiens (Human)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]	GO:0003924; GO:0005525; GO:0005829
GN019678	GN019678.1	Q9NUV9	40.2	184	375	329	1.70e-36	138	GIMA4_HUMAN	GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4)	Homo sapiens (Human)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]	GO:0003924; GO:0005525; GO:0005829
GN019680	GN019680.1	Q9NUV9	42.7	218	433	329	3.92e-48	170	GIMA4_HUMAN	GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4)	Homo sapiens (Human)		GTP binding [GO:0005525]; GTPase activity [GO:0003924]	cytosol [GO:0005829]	GO:0003924; GO:0005525; GO:0005829
GN019682	GN019682.1	Q28DF4	37.8	148	214	510	8.85e-25	104	PPM1H_XENTR	Protein phosphatase 1H (EC 3.1.3.16)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004721; GO:0004722; GO:0005634; GO:0005737
GN019683	GN019683.1	A5D6U8	34.5	420	517	443	6.05e-68	228	ACP7_DANRE	Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form)	Danio rerio (Zebrafish) (Brachydanio rerio)		acid phosphatase activity [GO:0003993]; metal ion binding [GO:0046872]	extracellular region [GO:0005576]	GO:0003993; GO:0005576; GO:0046872
GN019684	GN019684.1	P41252	60.7	1269	1277	1262	0.0	1555	SYIC_HUMAN	Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)	Homo sapiens (Human)	isoleucyl-tRNA aminoacylation [GO:0006428]; osteoblast differentiation [GO:0001649]; tRNA aminoacylation for protein translation [GO:0006418]	aminoacyl-tRNA deacylase activity [GO:0002161]; ATP binding [GO:0005524]; GTPase binding [GO:0051020]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0000049; GO:0001649; GO:0002161; GO:0004822; GO:0005524; GO:0005737; GO:0005829; GO:0006418; GO:0006428; GO:0016020; GO:0017101; GO:0051020; GO:0070062
GN019685	GN019685.1	P49139	66.2	361	390	366	1.69e-174	493	MAPK2_RABIT	MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)	Oryctolagus cuniculus (Rabbit)	3'-UTR-mediated mRNA stabilization [GO:0070935]; DNA damage response [GO:0006974]; inflammatory response [GO:0006954]; macropinocytosis [GO:0044351]; regulation of interleukin-6 production [GO:0032675]; regulation of tumor necrosis factor production [GO:0032680]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; toll-like receptor signaling pathway [GO:0002224]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0002224; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006954; GO:0006974; GO:0032496; GO:0032675; GO:0032680; GO:0034097; GO:0044351; GO:0070935; GO:0106310
GN019686	GN019686.1	Q9Z2F6	34.8	178	336	448	1.68e-18	89.4	BCL3_MOUSE	B-cell lymphoma 3 protein homolog (BCL-3)	Mus musculus (Mouse)	antimicrobial humoral response [GO:0019730]; canonical NF-kappaB signal transduction [GO:0007249]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; DNA damage response [GO:0006974]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of non-canonical NF-kappaB signal transduction [GO:1901223]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of type II interferon production [GO:0032729]; protein import into nucleus [GO:0006606]; regulation of apoptotic process [GO:0042981]; regulation of non-canonical NF-kappaB signal transduction [GO:1901222]; response to UV-C [GO:0010225]; response to virus [GO:0009615]; spleen development [GO:0048536]; T-helper 1 type immune response [GO:0042088]; T-helper 2 cell differentiation [GO:0045064]	DNA-binding transcription factor binding [GO:0140297]; histone deacetylase binding [GO:0042826]; protein-macromolecule adaptor activity [GO:0030674]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	Bcl3-Bcl10 complex [GO:0032996]; Bcl3/NF-kappaB2 complex [GO:0033257]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]	GO:0002268; GO:0002315; GO:0002455; GO:0002467; GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006606; GO:0006974; GO:0007249; GO:0009615; GO:0010225; GO:0019730; GO:0030198; GO:0030330; GO:0030496; GO:0030674; GO:0032717; GO:0032720; GO:0032729; GO:0032733; GO:0032991; GO:0032996; GO:0033257; GO:0036064; GO:0042088; GO:0042742; GO:0042771; GO:0042826; GO:0042832; GO:0042981; GO:0043066; GO:0045064; GO:0045727; GO:0045892; GO:0045893; GO:0045944; GO:0046426; GO:0048471; GO:0048536; GO:0140297; GO:1901222; GO:1901223
GN019687	GN019687.1	Q2TA20	38.6	114	581	364	1.14e-15	82.4	SPT22_BOVIN	Spermatogenesis-associated protein 22	Bos taurus (Bovine)	gamete generation [GO:0007276]; homologous chromosome pairing at meiosis [GO:0007129]; meiotic DNA repair synthesis [GO:0000711]; regulation of meiotic cell cycle [GO:0051445]		chromosome [GO:0005694]	GO:0000711; GO:0005694; GO:0007129; GO:0007276; GO:0051445
GN019688	GN019688.1	P19477	50.0	180	352	282	7.94e-53	179	FIBA_APOPA	Fibrinogen-like protein A (FREP-A)	Apostichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis)				
GN019689	GN019689.1	Q6AYB3	54.3	175	191	284	3.19e-58	187	ISY1_RAT	Pre-mRNA-splicing factor ISY1 homolog	Rattus norvegicus (Rat)	generation of catalytic spliceosome for second transesterification step [GO:0000350]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]		catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; post-spliceosomal complex [GO:0071020]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006]	GO:0000350; GO:0000389; GO:0000398; GO:0000974; GO:0005634; GO:0016607; GO:0071006; GO:0071013; GO:0071014; GO:0071020
GN019691	GN019691.1	O73746	31.7	205	269	214	1.60e-16	79.3	TIMP3_XENLA	Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3)	Xenopus laevis (African clawed frog)	negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]	metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]	GO:0002020; GO:0008191; GO:0008270; GO:0009725; GO:0031012; GO:0034097; GO:0051045
GN019695	GN019695.1	A5YVV0	31.5	612	695	661	4.87e-84	281	LAC3_ANOGA	Multicopper oxidase 3 (AgMCO3) (EC 1.10.3.2) (Laccase-3)	Anopheles gambiae (African malaria mosquito)		copper ion binding [GO:0005507]; hydroquinone:oxygen oxidoreductase activity [GO:0052716]	extracellular region [GO:0005576]	GO:0005507; GO:0005576; GO:0052716
GN019698	GN019698.1	Q5EBH1	32.2	295	679	413	1.55e-37	148	RASF5_MOUSE	Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL)	Mus musculus (Mouse)	negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein ubiquitination [GO:0031398]; regulation of protein localization to nucleus [GO:1900180]; signal transduction [GO:0007165]	identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005856; GO:0007165; GO:0008285; GO:0031398; GO:0042802; GO:1900180
GN019699	GN019699.1	Q7TP48	43.0	214	224	376	4.03e-51	172	APMAP_RAT	Adipocyte plasma membrane-associated protein	Rattus norvegicus (Rat)		arylesterase activity [GO:0004064]	cell surface [GO:0009986]; membrane [GO:0016020]	GO:0004064; GO:0009986; GO:0016020
GN019704	GN019704.1	A5YVV0	32.4	612	666	661	1.57e-87	290	LAC3_ANOGA	Multicopper oxidase 3 (AgMCO3) (EC 1.10.3.2) (Laccase-3)	Anopheles gambiae (African malaria mosquito)		copper ion binding [GO:0005507]; hydroquinone:oxygen oxidoreductase activity [GO:0052716]	extracellular region [GO:0005576]	GO:0005507; GO:0005576; GO:0052716
GN019707	GN019707.1	P86952	33.9	298	732	456	6.10e-35	142	TYRO_PINMA	Tyrosinase-like protein (Tyrosinase-2)	Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster)		oxidoreductase activity [GO:0016491]	extracellular region [GO:0005576]	GO:0005576; GO:0016491
GN019710	GN019710.1	F1QYJ6	33.7	252	294	296	3.27e-36	134	ST6B1_DANRE	Sulfotransferase 6B1 (EC 2.8.2.-) (Thyroxine sulfotransferase) (EC 2.8.2.n2)	Danio rerio (Zebrafish) (Brachydanio rerio)	cellular response to xenobiotic stimulus [GO:0071466]; sulfation [GO:0051923]	sulfotransferase activity [GO:0008146]	cytosol [GO:0005829]	GO:0005829; GO:0008146; GO:0051923; GO:0071466
GN019713	GN019713.1	O43704	33.3	270	294	296	7.41e-39	141	ST1B1_HUMAN	Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase)	Homo sapiens (Human)	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]	aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004062; GO:0005737; GO:0005829; GO:0006068; GO:0006576; GO:0006805; GO:0008146; GO:0009812; GO:0018958; GO:0030855; GO:0042403; GO:0050427; GO:0051923
GN019716	GN019716.1	P52842	35.7	269	294	285	5.67e-39	141	ST2A1_MACFA	Sulfotransferase 2A1 (ST2A1) (EC 2.8.2.2) (Bile salt sulfotransferase) (EC 2.8.2.14) (Hydroxysteroid sulfotransferase) (HST)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	cholesterol metabolic process [GO:0008203]; steroid metabolic process [GO:0008202]	3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; alcohol sulfotransferase activity [GO:0004027]; bile-salt sulfotransferase activity [GO:0047704]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146]	cytosol [GO:0005829]	GO:0004027; GO:0005829; GO:0008146; GO:0008202; GO:0008203; GO:0047704; GO:0050294; GO:0050656
GN019721	GN019721.1	Q6V0I7	28.7	1941	2016	4981	1.28e-163	565	FAT4_HUMAN	Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J)	Homo sapiens (Human)	axonogenesis [GO:0007409]; cell-cell adhesion mediated by cadherin [GO:0044331]; cerebral cortex development [GO:0021987]; epithelial cell differentiation [GO:0030855]; heterophilic cell-cell adhesion [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell-cell adhesion [GO:0007156]; neurogenesis [GO:0022008]	calcium ion binding [GO:0005509]	adherens junction [GO:0005912]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005912; GO:0007156; GO:0007157; GO:0007409; GO:0021987; GO:0022008; GO:0030855; GO:0035329; GO:0044331; GO:0070062
GN019722	GN019722.1	E9PVD3	35.9	117	166	3291	1.47e-09	59.3	PCD16_MOUSE	Protocadherin-16 (Protein Dchs1) (Protein dachsous homolog 1)	Mus musculus (Mouse)	anatomical structure morphogenesis [GO:0009653]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell migration [GO:0016477]; cell migration involved in endocardial cushion formation [GO:0003273]; cell-cell adhesion [GO:0098609]; cochlea development [GO:0090102]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; establishment of planar polarity [GO:0001736]; gene expression [GO:0010467]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell-cell adhesion [GO:0007156]; kidney development [GO:0001822]; mitral valve development [GO:0003174]; mitral valve formation [GO:0003192]; mitral valve morphogenesis [GO:0003183]; nephron development [GO:0072006]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; pattern specification process [GO:0007389]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]; septin cytoskeleton organization [GO:0032185]	beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]	apical part of cell [GO:0045177]; catenin complex [GO:0016342]	GO:0001658; GO:0001736; GO:0001822; GO:0003007; GO:0003174; GO:0003183; GO:0003192; GO:0003273; GO:0005509; GO:0007156; GO:0007157; GO:0007389; GO:0008013; GO:0009653; GO:0010467; GO:0016342; GO:0016477; GO:0021915; GO:0022008; GO:0032185; GO:0035329; GO:0036342; GO:0043931; GO:0045177; GO:0045296; GO:0048565; GO:0072006; GO:0072137; GO:0072659; GO:0090102; GO:0098609
GN019726	GN019726.1	Q99758	45.9	133	160	1704	1.66e-31	122	ABCA3_HUMAN	Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ABC-C transporter) (ATP-binding cassette sub-family A member 3) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form]	Homo sapiens (Human)	lipid transport [GO:0006869]; lung development [GO:0030324]; organelle assembly [GO:0070925]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid homeostasis [GO:0055091]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of protein homooligomerization [GO:0032464]; positive regulation of vesicle fusion [GO:0031340]; regulation of lipid biosynthetic process [GO:0046890]; regulation of phosphatidylcholine metabolic process [GO:0150172]; response to glucocorticoid [GO:0051384]; response to xenobiotic stimulus [GO:0009410]; surfactant homeostasis [GO:0043129]; xenobiotic export from cell [GO:0046618]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid carrier activity [GO:0005319]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine transfer activity [GO:0120019]	alveolar lamellar body [GO:0097208]; alveolar lamellar body membrane [GO:0097233]; cytoplasmic vesicle membrane [GO:0030659]; extracellular region [GO:0005576]; lamellar body [GO:0042599]; lamellar body membrane [GO:0097232]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]	GO:0005319; GO:0005524; GO:0005576; GO:0005765; GO:0005770; GO:0005886; GO:0006855; GO:0006869; GO:0008559; GO:0009410; GO:0010875; GO:0015914; GO:0016887; GO:0030324; GO:0030659; GO:0031340; GO:0031902; GO:0032464; GO:0032585; GO:0042599; GO:0042626; GO:0042908; GO:0043129; GO:0046470; GO:0046471; GO:0046618; GO:0046890; GO:0051384; GO:0055091; GO:0070925; GO:0097208; GO:0097232; GO:0097233; GO:0120019; GO:0140326; GO:0140345; GO:0150172; GO:1902995; GO:2001140
GN019727	GN019727.1	A0A0G2K1Q8	45.7	280	290	1704	1.71e-71	242	ABCA3_RAT	Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form]	Rattus norvegicus (Rat)	lung development [GO:0030324]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid homeostasis [GO:0055091]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of protein homooligomerization [GO:0032464]; positive regulation of vesicle fusion [GO:0031340]; regulation of lipid biosynthetic process [GO:0046890]; regulation of lipid transport [GO:0032368]; regulation of phosphatidylcholine metabolic process [GO:0150172]; response to glucocorticoid [GO:0051384]; surfactant homeostasis [GO:0043129]; xenobiotic export from cell [GO:0046618]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine transfer activity [GO:0120019]	alveolar lamellar body [GO:0097208]; alveolar lamellar body membrane [GO:0097233]; cytoplasmic vesicle membrane [GO:0030659]; lamellar body [GO:0042599]; lamellar body membrane [GO:0097232]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]	GO:0005524; GO:0005765; GO:0005770; GO:0005886; GO:0006855; GO:0008559; GO:0010875; GO:0015914; GO:0016887; GO:0030324; GO:0030659; GO:0031340; GO:0031902; GO:0032368; GO:0032464; GO:0032585; GO:0042599; GO:0042626; GO:0042908; GO:0043129; GO:0046470; GO:0046471; GO:0046618; GO:0046890; GO:0051384; GO:0055091; GO:0097208; GO:0097232; GO:0097233; GO:0120019; GO:0140326; GO:0140345; GO:0150172; GO:1902995; GO:2001140
GN019729	GN019729.1	Q5ZJ85	44.7	94	89	684	3.37e-14	69.3	PRPF3_CHICK	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3)	Gallus gallus (Chicken)	mRNA splicing, via spliceosome [GO:0000398]; spliceosomal tri-snRNP complex assembly [GO:0000244]		nuclear speck [GO:0016607]; nucleus [GO:0005634]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	GO:0000244; GO:0000398; GO:0005634; GO:0016607; GO:0046540
GN019730	GN019730.1	P21837	33.4	401	456	550	1.25e-49	180	CRYS_DICDI	Crystal protein	Dictyostelium discoideum (Social amoeba)	endocytosis [GO:0006897]; mitotic cytokinesis [GO:0000281]; sorocarp development [GO:0030587]	hydrolase activity, acting on ester bonds [GO:0016788]	early phagosome [GO:0032009]; esterosome membrane [GO:0033118]; extracellular matrix [GO:0031012]; lysosome [GO:0005764]	GO:0000281; GO:0005764; GO:0006897; GO:0016788; GO:0030587; GO:0031012; GO:0032009; GO:0033118
GN019731	GN019731.1	Q6GNL7	60.0	70	81	902	5.79e-21	88.2	AL1L1_XENLA	Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1)	Xenopus laevis (African clawed frog)	10-formyltetrahydrofolate catabolic process [GO:0009258]; aldehyde metabolic process [GO:0006081]; NADPH regeneration [GO:0006740]; one-carbon metabolic process [GO:0006730]	aldehyde dehydrogenase (NAD+) activity [GO:0004029]; formyltetrahydrofolate dehydrogenase activity [GO:0016155]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0004029; GO:0005739; GO:0005829; GO:0006081; GO:0006730; GO:0006740; GO:0009258; GO:0016155
GN019742	GN019742.1	Q6DFC2	57.1	471	471	496	1.17e-153	449	CCD77_XENLA	Coiled-coil domain-containing protein 77	Xenopus laevis (African clawed frog)			centrosome [GO:0005813]	GO:0005813
GN019743	GN019743.1	Q69Z37	24.0	1502	1843	1561	5.75e-78	290	SAM9L_MOUSE	Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like)	Mus musculus (Mouse)	common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145]		cytoplasm [GO:0005737]; early endosome [GO:0005769]; mitochondrion [GO:0005739]	GO:0002244; GO:0005737; GO:0005739; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536
GN019744	GN019744.1	Q9HCF6	41.2	1148	1085	1732	1.06e-264	797	TRPM3_HUMAN	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2)	Homo sapiens (Human)	calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; protein homotetramerization [GO:0051289]; zinc ion transmembrane transport [GO:0071577]	calcium channel activity [GO:0005262]; G-protein beta/gamma-subunit complex binding [GO:0031683]; monoatomic cation channel activity [GO:0005261]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	plasma membrane [GO:0005886]	GO:0005261; GO:0005262; GO:0005546; GO:0005886; GO:0006812; GO:0006816; GO:0031683; GO:0051289; GO:0070588; GO:0071577; GO:0098655
GN019748	GN019748.1	Q9P2Z0	36.6	82	128	257	1.38e-11	62.8	THA10_HUMAN	THAP domain-containing protein 10	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]		GO:0043565
GN019749	GN019749.1	Q9P2Z0	36.6	82	126	257	1.80e-11	62.4	THA10_HUMAN	THAP domain-containing protein 10	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]		GO:0043565
GN019750	GN019750.1	Q9U8W7	39.5	124	128	316	1.84e-22	92.8	TL5B_TACTR	Techylectin-5B	Tachypleus tridentatus (Japanese horseshoe crab)	cell-cell adhesion [GO:0098609]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]	carbohydrate binding [GO:0030246]; extracellular matrix structural constituent [GO:0005201]; protein-macromolecule adaptor activity [GO:0030674]	fibrinogen complex [GO:0005577]	GO:0005201; GO:0005577; GO:0030246; GO:0030674; GO:0034116; GO:0098609
GN019751	GN019751.1	E7F654	29.0	575	1033	713	7.41e-62	228	NOL9_DANRE	Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9)	Danio rerio (Zebrafish) (Brachydanio rerio)	cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000448]; definitive hemopoiesis [GO:0060216]; digestive tract development [GO:0048565]; exocrine pancreas development [GO:0031017]; liver development [GO:0001889]; pancreas morphogenesis [GO:0061113]; rRNA processing [GO:0006364]	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity [GO:0046404]; ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [GO:0051736]; polynucleotide 5'-hydroxyl-kinase activity [GO:0051731]	nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0000448; GO:0001889; GO:0005634; GO:0005730; GO:0006364; GO:0031017; GO:0046404; GO:0048565; GO:0051731; GO:0051736; GO:0060216; GO:0061113
GN019753	GN019753.1	Q03346	60.3	136	164	489	1.90e-44	155	MPPB_RAT	Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52)	Rattus norvegicus (Rat)	protein localization to mitochondrion [GO:0070585]; protein processing [GO:0016485]	endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; signal peptidase activity [GO:0009003]	mitochondrial matrix [GO:0005759]; mitochondrial processing peptidase complex [GO:0017087]; mitochondrion [GO:0005739]	GO:0004175; GO:0004222; GO:0005739; GO:0005759; GO:0009003; GO:0016485; GO:0017087; GO:0046872; GO:0070585
GN019754	GN019754.1	Q42290	68.5	92	117	531	1.19e-34	127	MPPB_ARATH	Probable mitochondrial-processing peptidase subunit beta, mitochondrial (EC 3.4.24.64) (Beta-MPP) (Complex III subunit I) (Core protein I) (Cytochrome b-c1 complex subunit 1, mitochondrial) (Ubiquinol-cytochrome c oxidoreductase core protein 1)	Arabidopsis thaliana (Mouse-ear cress)	proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]; signal peptidase activity [GO:0009003]; zinc ion binding [GO:0008270]	chloroplast [GO:0009507]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrial processing peptidase complex [GO:0017087]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; plant-type cell wall [GO:0009505]; plant-type vacuole [GO:0000325]; respiratory chain complex III [GO:0045275]	GO:0000325; GO:0004222; GO:0005730; GO:0005739; GO:0005741; GO:0005743; GO:0005758; GO:0005759; GO:0005829; GO:0006508; GO:0008270; GO:0009003; GO:0009505; GO:0009507; GO:0017087; GO:0045275
GN019755	GN019755.1	Q3SZ71	50.4	115	116	490	5.45e-32	120	MPPB_BOVIN	Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP)	Bos taurus (Bovine)	protein processing [GO:0016485]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; signal peptidase activity [GO:0009003]	mitochondrial matrix [GO:0005759]; mitochondrial processing peptidase complex [GO:0017087]	GO:0004222; GO:0005759; GO:0009003; GO:0016485; GO:0017087; GO:0046872
GN019756	GN019756.1	Q9CZ13	50.0	64	64	480	1.37e-18	80.5	QCR1_MOUSE	Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)	Mus musculus (Mouse)	cellular respiration [GO:0045333]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; mitochondrial respiratory chain complex III assembly [GO:0034551]; response to activity [GO:0014823]; response to alkaloid [GO:0043279]	metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]	mitochondrial inner membrane [GO:0005743]; mitochondrial processing peptidase complex [GO:0017087]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; respiratory chain complex III [GO:0045275]	GO:0005739; GO:0005743; GO:0006122; GO:0014823; GO:0017087; GO:0031625; GO:0034551; GO:0043209; GO:0043279; GO:0044877; GO:0045275; GO:0045333; GO:0046872
GN019757	GN019757.1	Q6NYH1	67.1	340	351	1187	1.68e-160	483	IF122_DANRE	Intraflagellar transport protein 122 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	camera-type eye morphogenesis [GO:0048593]; cilium assembly [GO:0060271]; heart development [GO:0007507]; intraciliary retrograde transport [GO:0035721]; intraciliary transport [GO:0042073]; melanosome transport [GO:0032402]; mesonephros development [GO:0001823]; negative regulation of smoothened signaling pathway [GO:0045879]; non-motile cilium assembly [GO:1905515]; opsin transport [GO:0036372]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell morphogenesis [GO:0008594]; protein localization to cilium [GO:0061512]; regulation of smoothened signaling pathway [GO:0008589]		ciliary basal body [GO:0036064]; cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]; non-motile cilium [GO:0097730]	GO:0001823; GO:0005929; GO:0007507; GO:0008589; GO:0008594; GO:0030991; GO:0032402; GO:0035721; GO:0036064; GO:0036372; GO:0042073; GO:0045494; GO:0045879; GO:0048593; GO:0060271; GO:0061512; GO:0097730; GO:1905515
GN019758	GN019758.1	Q5T653	46.7	195	221	305	1.07e-49	167	RM02_HUMAN	Large ribosomal subunit protein uL2m (39S ribosomal protein L2, mitochondrial) (L2mt) (MRP-L2)	Homo sapiens (Human)	mitochondrial translation [GO:0032543]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003723; GO:0003735; GO:0005739; GO:0005743; GO:0005762; GO:0032543
GN019759	GN019759.1	Q1LZ75	67.5	197	320	294	5.33e-94	283	ERCC1_BOVIN	DNA excision repair protein ERCC-1	Bos taurus (Bovine)	double-strand break repair [GO:0006302]; mitotic recombination [GO:0006312]; negative regulation of telomere maintenance [GO:0032205]; nucleotide-excision repair [GO:0006289]; response to oxidative stress [GO:0006979]; telomere maintenance [GO:0000723]; UV-damage excision repair [GO:0070914]	damaged DNA binding [GO:0003684]; single-stranded DNA binding [GO:0003697]	chromosome, telomeric region [GO:0000781]; ERCC4-ERCC1 complex [GO:0070522]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 1 complex [GO:0000110]; nucleus [GO:0005634]	GO:0000109; GO:0000110; GO:0000723; GO:0000781; GO:0003684; GO:0003697; GO:0005634; GO:0006289; GO:0006302; GO:0006312; GO:0006979; GO:0032205; GO:0070522; GO:0070914
GN019763	GN019763.1	Q5R8H3	50.4	246	236	246	1.22e-53	176	BAP31_PONAB	B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; protein localization to endoplasmic reticulum exit site [GO:0070973]		endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]	GO:0005789; GO:0006886; GO:0006888; GO:0033116; GO:0070973
GN019765	GN019765.1	Q86XH1	56.9	819	848	822	4.89e-272	777	DRC11_HUMAN	Dynein regulatory complex subunit 11 (IQ and AAA domain-containing protein 1)	Homo sapiens (Human)	cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]; microtubule severing [GO:0051013]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule severing ATPase activity [GO:0008568]	axonemal nexin link [GO:0005931]; axoneme [GO:0005930]	GO:0003341; GO:0005524; GO:0005930; GO:0005931; GO:0008568; GO:0016887; GO:0030317; GO:0051013
GN019766	GN019766.1	P51650	60.8	482	495	523	3.06e-209	592	SSDH_RAT	Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH) (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)	Rattus norvegicus (Rat)	central nervous system development [GO:0007417]; GABA catabolic process [GO:0009450]; GABA shunt [GO:0006540]; glutamate metabolic process [GO:0006536]; post-embryonic development [GO:0009791]; succinate metabolic process [GO:0006105]	carboxylic acid binding [GO:0031406]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004777; GO:0005739; GO:0005759; GO:0006105; GO:0006536; GO:0006540; GO:0007417; GO:0009450; GO:0009791; GO:0031406; GO:0042802; GO:0051287
GN019774	GN019774.1	Q9Z1J2	72.9	266	778	792	4.53e-128	404	NEK4_MOUSE	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; intracellular signal transduction [GO:0035556]; mitotic cell cycle [GO:0000278]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of DNA-templated transcription [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of monoatomic cation transmembrane transport [GO:1904062]	ATP binding [GO:0005524]; manganese ion binding [GO:0030145]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	ciliary basal body [GO:0036064]; ciliary plasm [GO:0097014]; ciliary rootlet [GO:0035253]; ciliary transition zone [GO:0035869]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0000278; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006974; GO:0030145; GO:0035253; GO:0035556; GO:0035869; GO:0036064; GO:0045893; GO:0090263; GO:0097014; GO:0106310; GO:1904062; GO:2000772
GN019775	GN019775.1	A0FKN5	36.9	762	900	742	2.81e-146	453	S26A5_CHICK	Prestin (Solute carrier family 26 member 5)	Gallus gallus (Chicken)		oxalate:chloride antiporter activity [GO:0160046]; sulfate:chloride antiporter activity [GO:0160044]	plasma membrane [GO:0005886]	GO:0005886; GO:0160044; GO:0160046
GN019776	GN019776.1	Q9SZJ2	38.5	283	811	787	5.48e-53	201	GRDP2_ARATH	Glycine-rich domain-containing protein 2 (AtGRDP2)	Arabidopsis thaliana (Mouse-ear cress)	cellular response to osmotic stress [GO:0071470]; regulation of auxin mediated signaling pathway [GO:0010928]; regulation of photoperiodism, flowering [GO:2000028]		cytoplasm [GO:0005737]	GO:0005737; GO:0010928; GO:0071470; GO:2000028
GN019778	GN019778.1	Q6DCQ0	46.3	190	475	398	4.92e-38	146	P4R2B_XENLA	Serine/threonine-protein phosphatase 4 regulatory subunit 2-B	Xenopus laevis (African clawed frog)		protein phosphatase regulator activity [GO:0019888]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein phosphatase 4 complex [GO:0030289]	GO:0005634; GO:0005737; GO:0019888; GO:0030289
GN019781	GN019781.1	Q8IW92	47.1	601	627	636	4.74e-182	532	GLBL2_HUMAN	Beta-galactosidase-1-like protein 2 (EC 3.2.1.23)	Homo sapiens (Human)	galactose catabolic process [GO:0019388]	beta-galactosidase activity [GO:0004565]	vacuole [GO:0005773]	GO:0004565; GO:0005773; GO:0019388
GN019782	GN019782.1	P42893	30.0	660	689	762	3.63e-77	265	ECE1_RAT	Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)	Rattus norvegicus (Rat)	axon guidance [GO:0007411]; axonogenesis involved in innervation [GO:0060385]; blood vessel diameter maintenance [GO:0097746]; bradykinin catabolic process [GO:0010815]; calcitonin catabolic process [GO:0010816]; ear development [GO:0043583]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube development [GO:0035050]; endothelin maturation [GO:0034959]; gene expression [GO:0010467]; heart development [GO:0007507]; hormone catabolic process [GO:0042447]; neuron projection development [GO:0031175]; peptide hormone processing [GO:0016486]; pharyngeal system development [GO:0060037]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of receptor recycling [GO:0001921]; protein processing [GO:0016485]; regulation of blood pressure [GO:0008217]; regulation of ERK1 and ERK2 cascade [GO:0070372]; response to cadmium ion [GO:0046686]; response to hypoxia [GO:0001666]; response to muscle stretch [GO:0035994]; response to xenobiotic stimulus [GO:0009410]; semaphorin-plexin signaling pathway [GO:0071526]; substance P catabolic process [GO:0010814]; sympathetic neuron axon guidance [GO:0097492]	endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093]	GO:0001666; GO:0001921; GO:0004175; GO:0004222; GO:0005768; GO:0005769; GO:0005886; GO:0007411; GO:0007507; GO:0008217; GO:0008270; GO:0009410; GO:0009897; GO:0010467; GO:0010613; GO:0010814; GO:0010815; GO:0010816; GO:0016020; GO:0016485; GO:0016486; GO:0030141; GO:0031175; GO:0031982; GO:0033093; GO:0034959; GO:0035050; GO:0035994; GO:0042447; GO:0042733; GO:0042802; GO:0042803; GO:0043583; GO:0045745; GO:0046686; GO:0048471; GO:0060037; GO:0060385; GO:0070372; GO:0071526; GO:0097492; GO:0097746; GO:0141163
GN019783	GN019783.1	Q6NT16	41.0	385	511	456	7.01e-93	293	S18B1_HUMAN	MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) (Vesicular polyamine transporter) (VPAT)	Homo sapiens (Human)	serotonin uptake [GO:0051610]; spermidine transport [GO:0015848]; spermine transport [GO:0000296]	monoamine:proton antiporter activity [GO:0015311]; polyamine:proton antiporter activity [GO:0015312]; transmembrane transporter activity [GO:0022857]	secretory granule membrane [GO:0030667]; synaptic vesicle membrane [GO:0030672]	GO:0000296; GO:0015311; GO:0015312; GO:0015848; GO:0022857; GO:0030667; GO:0030672; GO:0051610
GN019785	GN019785.1	Q641K5	60.3	63	347	658	1.92e-16	84.0	NUAK1_MOUSE	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (Omphalocele kinase 1)	Mus musculus (Mouse)	protein phosphorylation [GO:0006468]; regulation of cell adhesion [GO:0030155]; regulation of cellular senescence [GO:2000772]	ATP binding [GO:0005524]; p53 binding [GO:0002039]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001650; GO:0002039; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006468; GO:0015630; GO:0030155; GO:0106310; GO:2000772
GN019787	GN019787.1	Q6GLR7	51.1	141	184	1299	4.24e-43	156	CAPS1_XENLA	Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1)	Xenopus laevis (African clawed frog)	dense core granule exocytosis [GO:1990504]; exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; synaptic vesicle exocytosis [GO:0016079]		glutamatergic synapse [GO:0098978]; neuronal dense core vesicle membrane [GO:0099012]; presynapse [GO:0098793]; synapse [GO:0045202]	GO:0006887; GO:0016079; GO:0045202; GO:0045921; GO:0098793; GO:0098978; GO:0099012; GO:1990504
GN019788	GN019788.1	P22680	32.2	488	490	504	6.41e-63	216	CP7A1_HUMAN	Cytochrome P450 7A1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cholesterol 7-alpha-monooxygenase) (EC 1.14.14.23)	Homo sapiens (Human)	bile acid biosynthetic process [GO:0006699]; cellular response to cholesterol [GO:0071397]; cellular response to glucose stimulus [GO:0071333]; cholesterol catabolic process [GO:0006707]; cholesterol homeostasis [GO:0042632]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of fatty acid biosynthetic process [GO:0045717]; positive regulation of cholesterol biosynthetic process [GO:0045542]; regulation of bile acid biosynthetic process [GO:0070857]; response to ethanol [GO:0045471]; sterol metabolic process [GO:0016125]	24S-hydroxycholesterol 7-alpha-hydroxylase activity [GO:0033782]; cholesterol 7-alpha-monooxygenase activity [GO:0008123]; heme binding [GO:0020037]; iron ion binding [GO:0005506]	endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]	GO:0005506; GO:0005789; GO:0006699; GO:0006707; GO:0008123; GO:0016125; GO:0020037; GO:0032966; GO:0033782; GO:0042632; GO:0043231; GO:0045471; GO:0045542; GO:0045717; GO:0070857; GO:0071333; GO:0071397
GN019790	GN019790.1	Q0VCH3	54.1	98	193	121	5.88e-33	117	CDPF1_BOVIN	Cysteine-rich DPF motif domain-containing protein 1	Bos taurus (Bovine)				
GN019792	GN019792.1	Q99758	43.8	1343	1345	1704	0.0	1054	ABCA3_HUMAN	Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ABC-C transporter) (ATP-binding cassette sub-family A member 3) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form]	Homo sapiens (Human)	lipid transport [GO:0006869]; lung development [GO:0030324]; organelle assembly [GO:0070925]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid homeostasis [GO:0055091]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of protein homooligomerization [GO:0032464]; positive regulation of vesicle fusion [GO:0031340]; regulation of lipid biosynthetic process [GO:0046890]; regulation of phosphatidylcholine metabolic process [GO:0150172]; response to glucocorticoid [GO:0051384]; response to xenobiotic stimulus [GO:0009410]; surfactant homeostasis [GO:0043129]; xenobiotic export from cell [GO:0046618]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid carrier activity [GO:0005319]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine transfer activity [GO:0120019]	alveolar lamellar body [GO:0097208]; alveolar lamellar body membrane [GO:0097233]; cytoplasmic vesicle membrane [GO:0030659]; extracellular region [GO:0005576]; lamellar body [GO:0042599]; lamellar body membrane [GO:0097232]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]	GO:0005319; GO:0005524; GO:0005576; GO:0005765; GO:0005770; GO:0005886; GO:0006855; GO:0006869; GO:0008559; GO:0009410; GO:0010875; GO:0015914; GO:0016887; GO:0030324; GO:0030659; GO:0031340; GO:0031902; GO:0032464; GO:0032585; GO:0042599; GO:0042626; GO:0042908; GO:0043129; GO:0046470; GO:0046471; GO:0046618; GO:0046890; GO:0051384; GO:0055091; GO:0070925; GO:0097208; GO:0097232; GO:0097233; GO:0120019; GO:0140326; GO:0140345; GO:0150172; GO:1902995; GO:2001140
GN019794	GN019794.1	Q6NRK9	55.8	226	231	244	6.29e-95	280	CCNQ_XENLA	Cyclin-Q (Cyclin-related protein FAM58A)	Xenopus laevis (African clawed frog)	regulation of transcription by RNA polymerase II [GO:0006357]	cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]		GO:0006357; GO:0016538
GN019795	GN019795.1	Q9CR40	27.5	247	472	571	1.38e-21	101	KLH28_MOUSE	Kelch-like protein 28 (BTB/POZ domain-containing protein 5)	Mus musculus (Mouse)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]	ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]	GO:0005737; GO:0016567; GO:0031463; GO:0043161; GO:1990756
GN019796	GN019796.1	Q5R5X3	47.2	1169	1004	1186	1.02e-97	337	PUM1_PONAB	Pumilio homolog 1	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	3'-UTR-mediated mRNA destabilization [GO:0061158]; adult locomotory behavior [GO:0008344]; miRNA processing [GO:0035196]; mRNA destabilization [GO:0061157]; positive regulation of miRNA-mediated gene silencing [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; post-transcriptional gene silencing [GO:0016441]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of cell cycle [GO:0051726]; regulation of chromosome segregation [GO:0051983]; regulation of mRNA stability [GO:0043488]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]	miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; P-body [GO:0000932]	GO:0000932; GO:0003730; GO:0005737; GO:0005829; GO:0007283; GO:0008344; GO:0010608; GO:0016441; GO:0035196; GO:0035198; GO:0043488; GO:0048863; GO:0051726; GO:0051983; GO:0061157; GO:0061158; GO:1900246; GO:2000637
GN019797	GN019797.1	Q460N5	25.4	614	1695	1801	6.08e-45	183	PAR14_HUMAN	Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14)	Homo sapiens (Human)	NAD+ catabolic process [GO:0019677]; negative regulation of gene expression [GO:0010629]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein poly-ADP-ribosylation [GO:0070212]	enzyme binding [GO:0019899]; NAD+ binding [GO:0070403]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0003714; GO:0003950; GO:0005634; GO:0005737; GO:0005829; GO:0010629; GO:0016020; GO:0019677; GO:0019899; GO:0042531; GO:0042532; GO:0060336; GO:0070212; GO:0070403; GO:0140807; GO:1902216; GO:1990404
GN019799	GN019799.1	Q04073	50.7	452	479	459	1.17e-119	361	P3A2_STRPU	DNA-binding protein P3A2	Strongylocentrotus purpuratus (Purple sea urchin)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357
GN019801	GN019801.1	P41383	87.3	440	440	452	1.13e-292	798	TBA2_PATVU	Tubulin alpha-2/alpha-4 chain (EC 3.6.5.-)	Patella vulgata (Common limpet)	microtubule-based process [GO:0007017]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]	microtubule [GO:0005874]	GO:0003924; GO:0005200; GO:0005525; GO:0005874; GO:0007017
GN019802	GN019802.1	P49116	53.1	497	709	596	7.32e-159	474	NR2C2_HUMAN	Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)	Homo sapiens (Human)	cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of embryonic development [GO:0040019]; positive regulation of JNK cascade [GO:0046330]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0004879; GO:0005634; GO:0005654; GO:0006355; GO:0007399; GO:0008270; GO:0030154; GO:0033209; GO:0040019; GO:0043123; GO:0043565; GO:0045944; GO:0046330; GO:1990837
GN019803	GN019803.1	Q5NDL3	52.1	499	533	535	1.18e-184	531	EOGT_CHICK	EGF domain-specific O-linked N-acetylglucosamine transferase (EC 2.4.1.255) (Extracellular O-linked N-acetylglucosamine transferase)	Gallus gallus (Chicken)	protein O-linked glycosylation [GO:0006493]	protein O-acetylglucosaminyltransferase activity [GO:0097363]	endoplasmic reticulum lumen [GO:0005788]	GO:0005788; GO:0006493; GO:0097363
GN019804	GN019804.1	Q8CJH3	32.8	122	132	2119	2.63e-14	71.6	PLXB1_MOUSE	Plexin-B1	Mus musculus (Mouse)	inhibitory synapse assembly [GO:1904862]; negative regulation of cell adhesion [GO:0007162]; negative regulation of osteoblast proliferation [GO:0033689]; neuron projection morphogenesis [GO:0048812]; ossification involved in bone maturation [GO:0043931]; positive regulation of axonogenesis [GO:0050772]; positive regulation of GTPase activity [GO:0043547]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; semaphorin-plexin signaling pathway [GO:0071526]; synapse assembly [GO:0007416]	GTPase activating protein binding [GO:0032794]; semaphorin receptor activity [GO:0017154]	extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; semaphorin receptor complex [GO:0002116]	GO:0002116; GO:0005576; GO:0005886; GO:0007162; GO:0007416; GO:0008360; GO:0017154; GO:0030334; GO:0032794; GO:0033689; GO:0035025; GO:0043547; GO:0043931; GO:0045211; GO:0048812; GO:0050772; GO:0051493; GO:0051897; GO:0071526; GO:0098978; GO:1904862
GN019818	GN019818.1	Q9WYJ1	32.7	321	327	401	2.59e-43	156	TSAL_THEMA	L-threonine ammonia-lyase (EC 4.3.1.19) (L-serine ammonia-lyase) (EC 4.3.1.17) (Threonine dehydratase)	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	L-serine catabolic process [GO:0006565]; L-threonine catabolic process [GO:0006567]	L-serine ammonia-lyase activity [GO:0003941]; pyridoxal phosphate binding [GO:0030170]; threonine deaminase activity [GO:0004794]		GO:0003941; GO:0004794; GO:0006565; GO:0006567; GO:0030170
GN019819	GN019819.1	Q8R431	40.5	269	307	303	7.22e-66	211	MGLL_RAT	Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL)	Rattus norvegicus (Rat)	acylglycerol catabolic process [GO:0046464]; arachidonate metabolic process [GO:0019369]; long-term synaptic depression [GO:0060292]; monoacylglycerol catabolic process [GO:0052651]; positive regulation of vasoconstriction [GO:0045907]; regulation of axon extension [GO:0030516]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of inflammatory response [GO:0050727]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]; regulation of sensory perception of pain [GO:0051930]; regulation of signal transduction [GO:0009966]; response to ethanol [GO:0045471]; triglyceride catabolic process [GO:0019433]	hydrolase activity [GO:0016787]; monoacylglycerol lipase activity [GO:0047372]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; parallel fiber to Purkinje cell synapse [GO:0098688]; presynapse [GO:0098793]; synapse [GO:0045202]; varicosity [GO:0043196]	GO:0005811; GO:0005829; GO:0009966; GO:0016020; GO:0016787; GO:0019369; GO:0019433; GO:0030424; GO:0030516; GO:0042803; GO:0043196; GO:0045202; GO:0045471; GO:0045907; GO:0046464; GO:0047372; GO:0050727; GO:0051930; GO:0052651; GO:0060292; GO:0098688; GO:0098793; GO:0099178; GO:0150053; GO:2000124
GN019820	GN019820.1	Q8R431	33.3	174	174	303	1.22e-24	100	MGLL_RAT	Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL)	Rattus norvegicus (Rat)	acylglycerol catabolic process [GO:0046464]; arachidonate metabolic process [GO:0019369]; long-term synaptic depression [GO:0060292]; monoacylglycerol catabolic process [GO:0052651]; positive regulation of vasoconstriction [GO:0045907]; regulation of axon extension [GO:0030516]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of inflammatory response [GO:0050727]; regulation of retrograde trans-synaptic signaling by endocanabinoid [GO:0099178]; regulation of sensory perception of pain [GO:0051930]; regulation of signal transduction [GO:0009966]; response to ethanol [GO:0045471]; triglyceride catabolic process [GO:0019433]	hydrolase activity [GO:0016787]; monoacylglycerol lipase activity [GO:0047372]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; cytosol [GO:0005829]; lipid droplet [GO:0005811]; membrane [GO:0016020]; parallel fiber to Purkinje cell synapse [GO:0098688]; presynapse [GO:0098793]; synapse [GO:0045202]; varicosity [GO:0043196]	GO:0005811; GO:0005829; GO:0009966; GO:0016020; GO:0016787; GO:0019369; GO:0019433; GO:0030424; GO:0030516; GO:0042803; GO:0043196; GO:0045202; GO:0045471; GO:0045907; GO:0046464; GO:0047372; GO:0050727; GO:0051930; GO:0052651; GO:0060292; GO:0098688; GO:0098793; GO:0099178; GO:0150053; GO:2000124
GN019821	GN019821.1	Q8VCW8	27.1	207	251	615	1.12e-10	64.7	ACSF2_MOUSE	Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2)	Mus musculus (Mouse)		medium-chain fatty acid-CoA ligase activity [GO:0031956]	mitochondrion [GO:0005739]	GO:0005739; GO:0031956
GN019822	GN019822.1	Q9JJ66	66.7	243	256	499	3.39e-120	355	CDC20_MOUSE	Cell division cycle protein 20 homolog (mmCdc20) (p55CDC)	Mus musculus (Mouse)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; G2/M transition of mitotic cell cycle [GO:0000086]; metaphase/anaphase transition of cell cycle [GO:0044784]; metaphase/anaphase transition of meiosis I [GO:1990949]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly [GO:0090307]; mitotic spindle assembly checkpoint signaling [GO:0007094]; positive regulation of anaphase-promoting complex-dependent catabolic process [GO:1905786]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein deubiquitination [GO:0016579]; protein ubiquitination [GO:0016567]; regulation of dendrite development [GO:0050773]; regulation of meiotic nuclear division [GO:0040020]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	anaphase-promoting complex binding [GO:0010997]; histone deacetylase binding [GO:0042826]; ubiquitin ligase activator activity [GO:1990757]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	anaphase-promoting complex [GO:0005680]; centrosome [GO:0005813]; cytosol [GO:0005829]; kinetochore [GO:0000776]; mitotic checkpoint complex [GO:0033597]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; spindle pole [GO:0000922]	GO:0000086; GO:0000776; GO:0000922; GO:0005654; GO:0005680; GO:0005813; GO:0005829; GO:0007064; GO:0007094; GO:0008284; GO:0010997; GO:0016567; GO:0016579; GO:0031145; GO:0031146; GO:0031915; GO:0032991; GO:0033597; GO:0040020; GO:0042826; GO:0044784; GO:0045842; GO:0048471; GO:0050773; GO:0090129; GO:0090307; GO:1904668; GO:1905786; GO:1990756; GO:1990757; GO:1990949
GN019823	GN019823.1	Q5F359	59.3	91	125	188	6.59e-34	119	TPPC5_CHICK	Trafficking protein particle complex subunit 5	Gallus gallus (Chicken)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]		endoplasmic reticulum [GO:0005783]; TRAPPI protein complex [GO:1990070]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]	GO:0005783; GO:0006888; GO:1990070; GO:1990071; GO:1990072
GN019826	GN019826.1	C3YWU0	61.5	449	461	449	9.79e-222	619	FUCO_BRAFL	Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase)	Branchiostoma floridae (Florida lancelet) (Amphioxus)	fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]	alpha-L-fucosidase activity [GO:0004560]	extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0004560; GO:0005576; GO:0005764; GO:0006004; GO:0016139
GN019830	GN019830.1	Q8K9J1	26.3	274	834	264	1.55e-13	75.1	Y343_BUCAP	Uncharacterized metal-dependent hydrolase BUsg_343 (EC 3.1.-.-)	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)		DNA nuclease activity [GO:0004536]; hydrolase activity, acting on ester bonds [GO:0016788]	cytosol [GO:0005829]	GO:0004536; GO:0005829; GO:0016788
GN019831	GN019831.1	O18404	60.9	197	207	255	1.18e-81	246	HCD2_DROME	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51, EC 1.1.1.62) (3-hydroxyacyl-CoA dehydrogenase type II) (Hydroxysteroid dehydrogenase) (EC 1.1.1.-, EC 1.1.1.53) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Scully protein) (Type II HADH)	Drosophila melanogaster (Fruit fly)	acyl-CoA metabolic process [GO:0006637]; androgen metabolic process [GO:0008209]; ecdysone metabolic process [GO:0008205]; estrogen metabolic process [GO:0008210]; fatty acid metabolic process [GO:0006631]; L-isoleucine catabolic process [GO:0006550]; mitochondrial polycistronic RNA processing [GO:0140040]; mitochondrial tRNA 5'-end processing [GO:0097745]; mitochondrial tRNA processing [GO:0090646]; steroid metabolic process [GO:0008202]	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [GO:0003857]; 17-beta-hydroxysteroid dehydrogenase (NAD+) activity [GO:0044594]; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity [GO:0047015]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity [GO:0106282]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity [GO:0106283]	mitochondrial matrix [GO:0005759]; mitochondrial ribonuclease P complex [GO:0030678]; mitochondrion [GO:0005739]	GO:0003857; GO:0004303; GO:0005739; GO:0005759; GO:0006550; GO:0006631; GO:0006637; GO:0008202; GO:0008205; GO:0008209; GO:0008210; GO:0030678; GO:0044594; GO:0047015; GO:0047035; GO:0090646; GO:0097745; GO:0106282; GO:0106283; GO:0140040
GN019836	GN019836.1	Q17QZ3	25.1	414	367	495	4.76e-20	94.7	SPX3_BOVIN	Sugar phosphate exchanger 3 (Solute carrier family 37 member 3)	Bos taurus (Bovine)	xenobiotic transmembrane transport [GO:0006855]	xenobiotic transmembrane transporter activity [GO:0042910]	endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]	GO:0005765; GO:0005789; GO:0006855; GO:0042910
GN019838	GN019838.1	P02637	32.1	112	450	176	2.45e-10	62.8	SCP_MIZYE	Sarcoplasmic calcium-binding protein (SCP)	Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis)		calcium ion binding [GO:0005509]		GO:0005509
GN019841	GN019841.1	A0A0G2K1Q8	40.5	1379	1360	1704	0.0	970	ABCA3_RAT	Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form]	Rattus norvegicus (Rat)	lung development [GO:0030324]; phosphatidylcholine metabolic process [GO:0046470]; phosphatidylglycerol metabolic process [GO:0046471]; phospholipid homeostasis [GO:0055091]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of phospholipid efflux [GO:1902995]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of protein homooligomerization [GO:0032464]; positive regulation of vesicle fusion [GO:0031340]; regulation of lipid biosynthetic process [GO:0046890]; regulation of lipid transport [GO:0032368]; regulation of phosphatidylcholine metabolic process [GO:0150172]; response to glucocorticoid [GO:0051384]; surfactant homeostasis [GO:0043129]; xenobiotic export from cell [GO:0046618]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid carrier activity [GO:0140326]; ATPase-coupled transmembrane transporter activity [GO:0042626]; phosphatidylcholine flippase activity [GO:0140345]; phosphatidylcholine transfer activity [GO:0120019]	alveolar lamellar body [GO:0097208]; alveolar lamellar body membrane [GO:0097233]; cytoplasmic vesicle membrane [GO:0030659]; lamellar body [GO:0042599]; lamellar body membrane [GO:0097232]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]	GO:0005524; GO:0005765; GO:0005770; GO:0005886; GO:0006855; GO:0008559; GO:0010875; GO:0015914; GO:0016887; GO:0030324; GO:0030659; GO:0031340; GO:0031902; GO:0032368; GO:0032464; GO:0032585; GO:0042599; GO:0042626; GO:0042908; GO:0043129; GO:0046470; GO:0046471; GO:0046618; GO:0046890; GO:0051384; GO:0055091; GO:0097208; GO:0097232; GO:0097233; GO:0120019; GO:0140326; GO:0140345; GO:0150172; GO:1902995; GO:2001140
GN019842	GN019842.1	Q8K9J1	27.1	188	485	264	1.82e-09	62.0	Y343_BUCAP	Uncharacterized metal-dependent hydrolase BUsg_343 (EC 3.1.-.-)	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)		DNA nuclease activity [GO:0004536]; hydrolase activity, acting on ester bonds [GO:0016788]	cytosol [GO:0005829]	GO:0004536; GO:0005829; GO:0016788
GN019852	GN019852.1	P48148	90.6	181	336	192	1.95e-115	335	RHO1_DROME	Ras-like GTP-binding protein Rho1 (EC 3.6.5.2)	Drosophila melanogaster (Fruit fly)	actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; adherens junction maintenance [GO:0034334]; apical constriction [GO:0003383]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell elongation involved in imaginal disc-derived wing morphogenesis [GO:0090254]; cell migration [GO:0016477]; cell projection organization [GO:0030030]; cellularization [GO:0007349]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; determination of left/right symmetry [GO:0007368]; dorsal closure [GO:0007391]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; establishment of planar polarity of embryonic epithelium [GO:0042249]; establishment of protein localization [GO:0045184]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; gastrulation involving germ band extension [GO:0010004]; germ-band extension [GO:0007377]; glial cell migration [GO:0008347]; hemocyte migration [GO:0035099]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing hair organization [GO:0035317]; lumen formation, open tracheal system [GO:0035149]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; melanization defense response [GO:0035006]; mitotic actomyosin contractile ring assembly [GO:1903475]; mitotic cytokinesis [GO:0000281]; mitotic cytokinesis, division site positioning [GO:1902408]; motor neuron axon guidance [GO:0008045]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuroblast proliferation [GO:0007405]; neuron projection morphogenesis [GO:0048812]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of wound healing [GO:0090303]; posterior midgut invagination [GO:0007374]; protein localization involved in establishment of planar polarity [GO:0090251]; protein localization to adherens junction [GO:0071896]; pseudocleavage involved in syncytial blastoderm formation [GO:0030589]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actomyosin structure organization [GO:0110020]; regulation of axonogenesis [GO:0050770]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]; regulation of embryonic cell shape [GO:0016476]; regulation of filopodium assembly [GO:0051489]; regulation of locomotor rhythm [GO:1904059]; regulation of Malpighian tubule size [GO:0035298]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; response to wounding [GO:0009611]; salivary gland morphogenesis [GO:0007435]; small GTPase-mediated signal transduction [GO:0007264]; spiracle morphogenesis, open tracheal system [GO:0035277]; tracheal pit formation in open tracheal system [GO:0035202]; ventral furrow formation [GO:0007370]; wound healing [GO:0042060]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901]	apical cortex [GO:0045179]; apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; cell hair [GO:0070451]; cell-cell contact zone [GO:0044291]; cleavage furrow rim [GO:0090688]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	GO:0000281; GO:0001745; GO:0003383; GO:0003924; GO:0003925; GO:0005525; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005938; GO:0006897; GO:0007015; GO:0007264; GO:0007298; GO:0007349; GO:0007368; GO:0007370; GO:0007374; GO:0007377; GO:0007391; GO:0007395; GO:0007405; GO:0007411; GO:0007422; GO:0007424; GO:0007435; GO:0007480; GO:0008045; GO:0008347; GO:0009611; GO:0010004; GO:0016324; GO:0016328; GO:0016476; GO:0016477; GO:0019900; GO:0019901; GO:0030030; GO:0030036; GO:0030334; GO:0030589; GO:0030866; GO:0030950; GO:0032456; GO:0032956; GO:0034334; GO:0035006; GO:0035099; GO:0035149; GO:0035159; GO:0035202; GO:0035277; GO:0035298; GO:0035317; GO:0042060; GO:0042249; GO:0044291; GO:0045179; GO:0045184; GO:0045199; GO:0046663; GO:0048812; GO:0048813; GO:0050770; GO:0051017; GO:0051489; GO:0051493; GO:0070252; GO:0070451; GO:0070593; GO:0071896; GO:0071902; GO:0090090; GO:0090251; GO:0090254; GO:0090303; GO:0090688; GO:0110020; GO:1901739; GO:1902408; GO:1903475; GO:1904059
GN019859	GN019859.1	Q5F4A1	24.5	294	277	742	2.88e-12	70.1	G2E3_CHICK	G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase)	Gallus gallus (Chicken)	heterochromatin formation [GO:0031507]; pericentric heterochromatin formation [GO:0031508]; protein localization to chromosome [GO:0034502]; protein localization to condensed nuclear chromosome [GO:1903084]; protein ubiquitination [GO:0016567]	histone H3K14 ubiquitin ligase activity [GO:0140851]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]	GO:0005634; GO:0005721; GO:0005730; GO:0005737; GO:0016567; GO:0031507; GO:0031508; GO:0034502; GO:0140851; GO:1903084
GN019872	GN019872.1	Q2TBI2	39.8	83	106	584	1.33e-09	57.0	THAP4_BOVIN	Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric nitrobindin) (Nb(III)) (THAP domain-containing protein 4)	Bos taurus (Bovine)	cellular response to reactive nitrogen species [GO:1902170]	nitric oxide binding [GO:0070026]; peroxynitrite isomerase activity [GO:0062213]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0062213; GO:0070026; GO:1902170
GN019883	GN019883.1	Q9Y6R7	23.4	414	653	5405	1.27e-10	68.9	FCGBP_HUMAN	IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP)	Homo sapiens (Human)		extracellular matrix structural constituent [GO:0005201]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; Golgi lumen [GO:0005796]	GO:0005201; GO:0005796; GO:0031012; GO:0070062
GN019885	GN019885.1	Q3V3A7	28.6	182	1034	635	4.74e-13	77.0	RN207_MOUSE	RING finger protein 207	Mus musculus (Mouse)	positive regulation of gene expression [GO:0010628]; positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential [GO:1905026]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207]	Hsp70 protein binding [GO:0030544]; protein-folding chaperone binding [GO:0051087]; transmembrane transporter binding [GO:0044325]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]	GO:0005737; GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:1901207; GO:1905026
GN019887	GN019887.1	Q9CQQ8	83.8	99	114	103	8.88e-57	174	LSM7_MOUSE	U6 snRNA-associated Sm-like protein LSm7	Mus musculus (Mouse)	mRNA catabolic process [GO:0006402]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process [GO:0000956]	protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; Lsm1-7-Pat1 complex [GO:1990726]; Lsm2-8 complex [GO:0120115]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; spliceosomal tri-snRNP complex [GO:0097526]; U12-type spliceosomal complex [GO:0005689]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U6 snRNP [GO:0005688]	GO:0000398; GO:0000956; GO:0003723; GO:0005634; GO:0005681; GO:0005688; GO:0005689; GO:0005737; GO:0006402; GO:0046540; GO:0046982; GO:0071004; GO:0071005; GO:0071011; GO:0071013; GO:0097526; GO:0120115; GO:1990726
GN019889	GN019889.1	Q92753	41.5	106	441	470	1.34e-19	94.4	RORB_HUMAN	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)	Homo sapiens (Human)	amacrine cell differentiation [GO:0035881]; cellular response to retinoic acid [GO:0071300]; eye photoreceptor cell development [GO:0042462]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of circadian rhythm [GO:0042752]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; melatonin receptor activity [GO:0008502]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0004879; GO:0005634; GO:0005654; GO:0006355; GO:0006357; GO:0008270; GO:0008502; GO:0035881; GO:0042462; GO:0042752; GO:0045668; GO:0045892; GO:0045893; GO:0045944; GO:0046548; GO:0046549; GO:0060041; GO:0071300; GO:1990837
GN019891	GN019891.1	Q5E9Y6	36.8	356	555	453	1.57e-51	186	PRUN1_BOVIN	Exopolyphosphatase PRUNE1 (EC 3.6.1.14) (EC 3.6.1.25)	Bos taurus (Bovine)		3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; adenosine-tetraphosphatase activity [GO:0047624]; exopolyphosphatase activity [GO:0004309]; inorganic triphosphate phosphatase activity [GO:0050355]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; nucleus [GO:0005634]	GO:0004115; GO:0004309; GO:0005634; GO:0005737; GO:0005925; GO:0047555; GO:0047624; GO:0050355
GN019892	GN019892.1	Q8VCV9	27.7	405	555	425	6.73e-31	128	MF4B1_MOUSE	Sodium-dependent glucose transporter 1A (Major facilitator superfamily domain-containing protein 4B1)	Mus musculus (Mouse)		transmembrane transporter activity [GO:0022857]	apical plasma membrane [GO:0016324]	GO:0016324; GO:0022857
GN019893	GN019893.1	Q6NWZ9	54.5	200	219	201	2.57e-81	244	CDO1_DANRE	Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I)	Danio rerio (Zebrafish) (Brachydanio rerio)	L-cysteine catabolic process [GO:0019448]; taurine biosynthetic process [GO:0042412]	cysteine dioxygenase activity [GO:0017172]; ferrous iron binding [GO:0008198]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270]		GO:0008198; GO:0008270; GO:0016151; GO:0017172; GO:0019448; GO:0042412
GN019894	GN019894.1	P38411	86.7	353	353	353	8.14e-223	613	GNAQ_LYMST	Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]	G protein-coupled receptor binding [GO:0001664]; G-protein beta/gamma-subunit complex binding [GO:0031683]; GTPase activity [GO:0003924]; guanyl nucleotide binding [GO:0019001]	cytoplasm [GO:0005737]; heterotrimeric G-protein complex [GO:0005834]	GO:0001664; GO:0003924; GO:0005737; GO:0005834; GO:0007188; GO:0019001; GO:0031683
GN019895	GN019895.1	Q6P5M2	66.7	123	311	305	3.01e-57	189	SKI8_DANRE	Superkiller complex protein 8 (Ski8) (WD repeat-containing protein 61)	Danio rerio (Zebrafish) (Brachydanio rerio)	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [GO:0070478]; rescue of stalled cytosolic ribosome [GO:0072344]; transcription elongation by RNA polymerase II [GO:0006368]		Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; nucleus [GO:0005634]; Ski complex [GO:0055087]	GO:0000791; GO:0005634; GO:0005737; GO:0006368; GO:0016593; GO:0055087; GO:0070478; GO:0072344
GN019897	GN019897.1	Q64267	54.3	256	273	272	5.44e-84	255	XPA_MOUSE	DNA repair protein complementing XP-A cells homolog (Xeroderma pigmentosum group A-complementing protein homolog)	Mus musculus (Mouse)	base-excision repair [GO:0006284]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; multicellular organism growth [GO:0035264]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair involved in interstrand cross-link repair [GO:1901255]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein localization to nucleus [GO:0034504]; regulation of autophagy [GO:0010506]; response to oxidative stress [GO:0006979]; response to toxic substance [GO:0009636]; response to UV [GO:0009411]; UV protection [GO:0009650]; UV-damage excision repair [GO:0070914]	damaged DNA binding [GO:0003684]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; sequence-specific double-stranded DNA binding [GO:1990837]	cytosol [GO:0005829]; DNA replication factor A complex [GO:0005662]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleotide-excision repair factor 1 complex [GO:0000110]; nucleus [GO:0005634]	GO:0000110; GO:0000715; GO:0003684; GO:0005634; GO:0005654; GO:0005662; GO:0005829; GO:0006281; GO:0006284; GO:0006289; GO:0006979; GO:0008630; GO:0009411; GO:0009636; GO:0009650; GO:0010506; GO:0016604; GO:0019904; GO:0034504; GO:0035264; GO:0042803; GO:0060261; GO:0070914; GO:1901255; GO:1990837
GN019898	GN019898.1	Q60520	54.8	1228	1319	1274	0.0	1157	SIN3A_MOUSE	Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)	Mus musculus (Mouse)	activation of innate immune response [GO:0002218]; cellular response to dopamine [GO:1903351]; cellular response to glucose stimulus [GO:0071333]; cellular response to tert-butyl hydroperoxide [GO:0072736]; cerebral cortex neuron differentiation [GO:0021895]; DNA replication [GO:0006260]; hematopoietic progenitor cell differentiation [GO:0002244]; heterochromatin formation [GO:0031507]; in utero embryonic development [GO:0001701]; intracellular protein localization [GO:0008104]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of stem cell population maintenance [GO:1902459]; regulation of axon extension [GO:0030516]; regulation of DNA-templated transcription [GO:0006355]; regulation of hormone levels [GO:0010817]; response to methylglyoxal [GO:0051595]; type I interferon-mediated signaling pathway [GO:0060337]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription corepressor activity [GO:0003714]; transcription regulator inhibitor activity [GO:0140416]	chromatin [GO:0000785]; histone deacetylase complex [GO:0000118]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; Sin3-type complex [GO:0070822]; transcription regulator complex [GO:0005667]; transcription repressor complex [GO:0017053]	GO:0000118; GO:0000122; GO:0000776; GO:0000785; GO:0001701; GO:0002218; GO:0002230; GO:0002244; GO:0003677; GO:0003682; GO:0003714; GO:0003723; GO:0005634; GO:0005654; GO:0005667; GO:0005730; GO:0006260; GO:0006355; GO:0008104; GO:0010817; GO:0010971; GO:0017053; GO:0021895; GO:0030336; GO:0030512; GO:0030516; GO:0031507; GO:0032991; GO:0042754; GO:0043066; GO:0044877; GO:0045666; GO:0045892; GO:0051595; GO:0060337; GO:0061629; GO:0070822; GO:0071333; GO:0072736; GO:0140416; GO:1900181; GO:1902455; GO:1902459; GO:1903351
GN019900	GN019900.1	O93530	30.6	343	373	1436	4.44e-36	143	WRN_XENLA	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Focus-forming activity 1) (FFA-1) (Werner syndrome protein homolog) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Xenopus laevis (African clawed frog)	DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; four-way junction helicase activity [GO:0009378]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000723; GO:0000724; GO:0000781; GO:0003676; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006259; GO:0006260; GO:0008408; GO:0009378; GO:0016887; GO:0030145; GO:0032392; GO:0043138
GN019901	GN019901.1	Q7SYH5	44.3	555	656	622	6.18e-147	443	SC5A8_XENLA	Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (xSMCTe) (Sodium solute transporter Vito) (Solute carrier family 5 member 8)	Xenopus laevis (African clawed frog)	acetate transport [GO:0006846]; chloride transport [GO:0006821]; iodide transport [GO:0015705]; lactate transport [GO:0015727]; nicotinate transport [GO:2001142]; nitrate transmembrane transport [GO:0015706]; propanoate transmembrane transport [GO:0015730]; pyruvate transport [GO:0006848]; sodium ion transport [GO:0006814]	monocarboxylate:sodium symporter activity [GO:0140161]; organic acid:sodium symporter activity [GO:0005343]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	GO:0005343; GO:0005886; GO:0006814; GO:0006821; GO:0006846; GO:0006848; GO:0015705; GO:0015706; GO:0015727; GO:0015730; GO:0016324; GO:0070062; GO:0140161; GO:2001142
GN019911	GN019911.1	Q8IRI6	54.2	421	483	1440	5.24e-145	453	GTR1_DROME	Glucose transporter type 1	Drosophila melanogaster (Fruit fly)	glucose homeostasis [GO:0042593]; monosaccharide transmembrane transport [GO:0015749]; positive regulation of peptide hormone secretion [GO:0090277]	hexose transmembrane transporter activity [GO:0015149]	apical plasma membrane [GO:0016324]; membrane [GO:0016020]	GO:0015149; GO:0015749; GO:0016020; GO:0016324; GO:0042593; GO:0090277
GN019917	GN019917.1	A2AJ76	25.4	378	696	5100	2.44e-10	68.2	HMCN2_MOUSE	Hemicentin-2	Mus musculus (Mouse)	homophilic cell-cell adhesion [GO:0007156]; synapse organization [GO:0050808]	axon guidance receptor activity [GO:0008046]; calcium ion binding [GO:0005509]	axon [GO:0030424]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; neuronal cell body [GO:0043025]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005509; GO:0005576; GO:0005604; GO:0005886; GO:0005938; GO:0007156; GO:0008046; GO:0030054; GO:0030424; GO:0031012; GO:0032154; GO:0043025; GO:0050808; GO:0140144
GN019928	GN019928.1	Q9PSZ3	38.7	75	783	452	1.63e-10	67.8	ADA11_XENLA	Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (MDC11.1) (Metalloprotease-disintegrin MDC11a) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC)	Xenopus laevis (African clawed frog)	epithelial to mesenchymal transition [GO:0001837]; neural crest cell migration [GO:0001755]; neural tube closure [GO:0001843]; proteolysis [GO:0006508]	metalloendopeptidase activity [GO:0004222]	axon [GO:0030424]; perikaryon [GO:0043204]; presynaptic membrane [GO:0042734]	GO:0001755; GO:0001837; GO:0001843; GO:0004222; GO:0006508; GO:0030424; GO:0042734; GO:0043204
GN019938	GN019938.1	Q99M80	32.6	561	749	1454	4.27e-81	286	PTPRT_MOUSE	Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho)	Mus musculus (Mouse)	cell surface receptor protein tyrosine kinase signaling pathway [GO:0007169]; cellular response to interleukin-6 [GO:0071354]; homophilic cell-cell adhesion [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of receptor signaling pathway via STAT [GO:1904893]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; regulation of synapse organization [GO:0050807]; signal transduction [GO:0007165]	alpha-actinin binding [GO:0051393]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine phosphatase activity [GO:0004725]; STAT family protein binding [GO:0097677]; thiolester hydrolase activity [GO:0016790]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]	GO:0004725; GO:0005001; GO:0005886; GO:0006470; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016790; GO:0019903; GO:0030336; GO:0031175; GO:0042803; GO:0045294; GO:0045295; GO:0045296; GO:0050807; GO:0051393; GO:0070097; GO:0071354; GO:0097677; GO:0098839; GO:0098978; GO:1904893
GN019939	GN019939.1	Q08D64	53.6	838	855	849	8.98e-284	808	ABCB6_XENTR	ATP-binding cassette sub-family B member 6 (ABC-type heme transporter ABCB6) (EC 7.6.2.5)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cellular detoxification of cadmium ion [GO:0098849]; heme metabolic process [GO:0042168]; heme transmembrane transport [GO:0035351]; intracellular copper ion homeostasis [GO:0006878]; melanosome assembly [GO:1903232]; porphyrin-containing compound metabolic process [GO:0006778]; tetrapyrrole metabolic process [GO:0033013]	ABC-type heme transporter activity [GO:0015439]; ABC-type transporter activity [GO:0140359]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; tetrapyrrole binding [GO:0046906]	early endosome membrane [GO:0031901]; endolysosome membrane [GO:0036020]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; melanosome membrane [GO:0033162]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]	GO:0000139; GO:0005524; GO:0005739; GO:0005741; GO:0005765; GO:0005789; GO:0005794; GO:0005886; GO:0006778; GO:0006878; GO:0010008; GO:0015439; GO:0016887; GO:0031901; GO:0031902; GO:0032585; GO:0033013; GO:0033162; GO:0035351; GO:0036020; GO:0042168; GO:0046906; GO:0070062; GO:0098849; GO:0140359; GO:1903232
GN019941	GN019941.1	Q9BX70	29.3	437	426	525	3.96e-50	180	BTBD2_HUMAN	BTB/POZ domain-containing protein 2	Homo sapiens (Human)	neurogenesis [GO:0022008]		cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; P-body [GO:0000932]	GO:0000932; GO:0005737; GO:0005829; GO:0022008; GO:0036464
GN019942	GN019942.1	O70165	48.0	127	228	334	2.22e-36	133	FCN1_MOUSE	Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)	Mus musculus (Mouse)	cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of interleukin-8 production [GO:0032757]	antigen binding [GO:0003823]; calcium-dependent protein binding [GO:0048306]; carbohydrate derivative binding [GO:0097367]; G protein-coupled receptor binding [GO:0001664]; identical protein binding [GO:0042802]; lipoteichoic acid immune receptor activity [GO:0070892]; mannan binding [GO:2001065]; pattern recognition receptor activity [GO:0038187]; proteoglycan binding [GO:0043394]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]	GO:0001664; GO:0001867; GO:0002752; GO:0003823; GO:0005102; GO:0005576; GO:0005886; GO:0007186; GO:0009986; GO:0031012; GO:0032757; GO:0033691; GO:0038187; GO:0042802; GO:0043394; GO:0048306; GO:0070892; GO:0097367; GO:0106139; GO:2001065
GN019944	GN019944.1	P57756	43.5	124	124	319	9.58e-28	106	FCN2_RAT	Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin)	Rattus norvegicus (Rat)	cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; host-mediated suppression of symbiont invasion [GO:0046597]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of opsonization [GO:1903028]; protein localization to cell surface [GO:0034394]; proteolysis [GO:0006508]; recognition of apoptotic cell [GO:0043654]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; G protein-coupled receptor binding [GO:0001664]; lipoteichoic acid immune receptor activity [GO:0070892]; pattern recognition receptor activity [GO:0038187]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; serine-type endopeptidase complex [GO:1905370]; symbiont cell surface [GO:0106139]	GO:0001664; GO:0001867; GO:0002752; GO:0003823; GO:0005102; GO:0005576; GO:0005886; GO:0006508; GO:0007186; GO:0009986; GO:0031012; GO:0032757; GO:0033691; GO:0034394; GO:0038187; GO:0043654; GO:0046597; GO:0070892; GO:0097367; GO:0106139; GO:1903028; GO:1905370
GN019949	GN019949.1	O35379	39.2	848	901	1528	7.00e-171	539	MRP1_MOUSE	ATP-binding cassette sub-family C member 1 (EC 7.6.2.-) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) (Multidrug resistance-associated protein 1) (EC 7.6.2.2)	Mus musculus (Mouse)	amygdala development [GO:0021764]; amyloid-beta clearance [GO:0097242]; amyloid-beta metabolic process [GO:0050435]; antigen processing and presentation of lipid antigen via MHC class Ib [GO:0048003]; apoptotic process [GO:0006915]; astrocyte differentiation [GO:0048708]; bilirubin transport [GO:0015723]; blood vessel diameter maintenance [GO:0097746]; carboxylic acid transmembrane transport [GO:1905039]; cell chemotaxis [GO:0060326]; cell redox homeostasis [GO:0045454]; cellular response to amyloid-beta [GO:1904646]; cellular response to type II interferon [GO:0071346]; cobalamin transport [GO:0015889]; cyclic nucleotide transport [GO:0070729]; defense response to Gram-positive bacterium [GO:0050830]; DNA damage response [GO:0006974]; endothelial cell apoptotic process [GO:0072577]; endothelium development [GO:0003158]; exploration behavior [GO:0035640]; export across plasma membrane [GO:0140115]; export from cell [GO:0140352]; fibroblast apoptotic process [GO:0044346]; gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; glucocorticoid metabolic process [GO:0008211]; glutathione metabolic process [GO:0006749]; glutathione transmembrane transport [GO:0034775]; glutathione transport [GO:0034635]; granuloma formation [GO:0002432]; hippocampus development [GO:0021766]; hydrogen peroxide biosynthetic process [GO:0050665]; immune response [GO:0006955]; inflammatory response [GO:0006954]; inflammatory response to antigenic stimulus [GO:0002437]; intracellular chemical homeostasis [GO:0055082]; intracellular nitrogen homeostasis [GO:0141067]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; long-chain fatty acid import across plasma membrane [GO:0015911]; lymphocyte migration [GO:0072676]; macrophage activation [GO:0042116]; memory [GO:0007613]; multicellular organism growth [GO:0035264]; neural tissue regeneration [GO:0097719]; neurogenesis [GO:0022008]; NK T cell activation [GO:0051132]; phospholipid efflux [GO:0033700]; phospholipid translocation [GO:0045332]; pigment accumulation [GO:0043476]; positive regulation of cell migration [GO:0030335]; positive regulation of inflammatory response [GO:0050729]; protein localization to cell surface [GO:0034394]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of catalytic activity [GO:0050790]; regulation of cellular response to drug [GO:2001038]; regulation of membrane potential [GO:0042391]; response to fluid shear stress [GO:0034405]; response to glucocorticoid [GO:0051384]; response to oxidative stress [GO:0006979]; response to toxic substance [GO:0009636]; response to type II interferon [GO:0034341]; response to xenobiotic stimulus [GO:0009410]; sphingolipid translocation [GO:0099039]; superoxide anion generation [GO:0042554]; tetrahydrobiopterin metabolic process [GO:0046146]; tissue homeostasis [GO:0001894]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; vasodilation [GO:0042311]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type vitamin B12 transporter activity [GO:0015420]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; carboxylic acid transmembrane transporter activity [GO:0046943]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	GO:0001894; GO:0002432; GO:0002437; GO:0003158; GO:0005324; GO:0005524; GO:0005886; GO:0006691; GO:0006749; GO:0006855; GO:0006915; GO:0006954; GO:0006955; GO:0006974; GO:0006979; GO:0007613; GO:0008211; GO:0008559; GO:0009410; GO:0009636; GO:0009925; GO:0010001; GO:0010467; GO:0015420; GO:0015431; GO:0015562; GO:0015723; GO:0015889; GO:0015911; GO:0016323; GO:0016324; GO:0016328; GO:0016887; GO:0019370; GO:0021764; GO:0021766; GO:0022008; GO:0022857; GO:0030054; GO:0030335; GO:0033700; GO:0034040; GO:0034341; GO:0034394; GO:0034405; GO:0034634; GO:0034635; GO:0034775; GO:0035264; GO:0035640; GO:0042116; GO:0042311; GO:0042391; GO:0042554; GO:0042908; GO:0042910; GO:0043476; GO:0044346; GO:0045332; GO:0045454; GO:0046146; GO:0046943; GO:0048003; GO:0048708; GO:0050435; GO:0050665; GO:0050729; GO:0050790; GO:0050830; GO:0051132; GO:0051384; GO:0055082; GO:0055085; GO:0060326; GO:0070633; GO:0070729; GO:0071346; GO:0071716; GO:0072577; GO:0072676; GO:0097242; GO:0097719; GO:0097746; GO:0099039; GO:0140115; GO:0140352; GO:0140359; GO:0141067; GO:1903409; GO:1904646; GO:1905039; GO:1990961; GO:1990962; GO:2001038
GN019950	GN019950.1	P33527	55.0	491	513	1531	6.34e-172	527	MRP1_HUMAN	ATP-binding cassette sub-family C member 1 (EC 7.6.2.-) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) (Multidrug resistance-associated protein 1) (EC 7.6.2.2)	Homo sapiens (Human)	carboxylic acid transmembrane transport [GO:1905039]; cell chemotaxis [GO:0060326]; cellular response to amyloid-beta [GO:1904646]; cellular response to oxidative stress [GO:0034599]; cobalamin transport [GO:0015889]; cyclic nucleotide transport [GO:0070729]; export across plasma membrane [GO:0140115]; glutathione transmembrane transport [GO:0034775]; heme catabolic process [GO:0042167]; leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; phospholipid translocation [GO:0045332]; positive regulation of inflammatory response [GO:0050729]; response to xenobiotic stimulus [GO:0009410]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid translocation [GO:0099039]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type vitamin B12 transporter activity [GO:0015420]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carboxylic acid transmembrane transporter activity [GO:0046943]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005524; GO:0005886; GO:0006691; GO:0006805; GO:0008559; GO:0009410; GO:0009925; GO:0015420; GO:0015431; GO:0015562; GO:0015889; GO:0016020; GO:0016323; GO:0016324; GO:0016328; GO:0016887; GO:0030054; GO:0030148; GO:0034040; GO:0034599; GO:0034634; GO:0034775; GO:0042167; GO:0042626; GO:0042908; GO:0042910; GO:0045332; GO:0046943; GO:0050729; GO:0055085; GO:0060326; GO:0070062; GO:0070633; GO:0070729; GO:0071716; GO:0099039; GO:0140115; GO:0140359; GO:0150104; GO:1904646; GO:1905039; GO:1990962
GN019951	GN019951.1	Q8NBX0	40.2	122	352	429	8.65e-18	87.4	SCPDL_HUMAN	Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-)	Homo sapiens (Human)	glycolipid biosynthetic process [GO:0009247]		extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]	GO:0005576; GO:0005634; GO:0005739; GO:0005811; GO:0009247; GO:0016020; GO:0030496; GO:0031093
GN019953	GN019953.1	Q8NBX0	34.6	185	197	429	2.31e-20	90.9	SCPDL_HUMAN	Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-)	Homo sapiens (Human)	glycolipid biosynthetic process [GO:0009247]		extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; platelet alpha granule lumen [GO:0031093]	GO:0005576; GO:0005634; GO:0005739; GO:0005811; GO:0009247; GO:0016020; GO:0030496; GO:0031093
GN019954	GN019954.1	Q8N4P6	30.5	587	598	559	2.22e-47	177	LRC71_HUMAN	Leucine-rich repeat-containing protein 71	Homo sapiens (Human)				
GN019961	GN019961.1	A0A2R8QP51	46.1	783	765	885	6.63e-220	643	DPP9_DANRE	Dipeptidyl peptidase 9 (EC 3.4.14.5)	Danio rerio (Zebrafish) (Brachydanio rerio)	proteolysis [GO:0006508]; regulation of inflammatory response [GO:0050727]	dipeptidyl-peptidase activity [GO:0008239]; serine-type peptidase activity [GO:0008236]	nucleus [GO:0005634]	GO:0005634; GO:0006508; GO:0008236; GO:0008239; GO:0050727
GN019963	GN019963.1	Q62902	57.5	146	165	517	1.07e-57	191	LMAN1_RAT	Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Lectin mannose-binding 1) (p58)	Rattus norvegicus (Rat)	endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; gene expression [GO:0010467]; Golgi organization [GO:0007030]; in utero embryonic development [GO:0001701]	calcium ion binding [GO:0005509]; D-mannose binding [GO:0005537]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; postsynaptic Golgi apparatus [GO:0150051]; sarcomere [GO:0030017]	GO:0000139; GO:0001701; GO:0005509; GO:0005537; GO:0005783; GO:0005789; GO:0005793; GO:0005794; GO:0006888; GO:0007029; GO:0007030; GO:0010467; GO:0030017; GO:0030134; GO:0033116; GO:0042802; GO:0046872; GO:0098978; GO:0150051
GN019964	GN019964.1	Q9D0F3	32.3	96	248	517	8.61e-09	58.9	LMAN1_MOUSE	Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Lectin mannose-binding 1) (p58)	Mus musculus (Mouse)	endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; gene expression [GO:0010467]; Golgi organization [GO:0007030]; in utero embryonic development [GO:0001701]	D-mannose binding [GO:0005537]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	cargo receptor complex [GO:0062137]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular matrix [GO:0031012]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; postsynaptic Golgi apparatus [GO:0150051]; sarcomere [GO:0030017]	GO:0000139; GO:0001701; GO:0005537; GO:0005783; GO:0005789; GO:0005793; GO:0005794; GO:0006888; GO:0007029; GO:0007030; GO:0010467; GO:0030017; GO:0030134; GO:0031012; GO:0033116; GO:0042802; GO:0046872; GO:0062137; GO:0098978; GO:0150051
GN019965	GN019965.1	Q7SYH5	38.8	578	651	622	2.12e-130	400	SC5A8_XENLA	Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (xSMCTe) (Sodium solute transporter Vito) (Solute carrier family 5 member 8)	Xenopus laevis (African clawed frog)	acetate transport [GO:0006846]; chloride transport [GO:0006821]; iodide transport [GO:0015705]; lactate transport [GO:0015727]; nicotinate transport [GO:2001142]; nitrate transmembrane transport [GO:0015706]; propanoate transmembrane transport [GO:0015730]; pyruvate transport [GO:0006848]; sodium ion transport [GO:0006814]	monocarboxylate:sodium symporter activity [GO:0140161]; organic acid:sodium symporter activity [GO:0005343]	apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	GO:0005343; GO:0005886; GO:0006814; GO:0006821; GO:0006846; GO:0006848; GO:0015705; GO:0015706; GO:0015727; GO:0015730; GO:0016324; GO:0070062; GO:0140161; GO:2001142
GN019985	GN019985.1	Q86Z23	34.5	113	216	238	1.01e-11	65.5	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN019986	GN019986.1	P13670	42.7	75	66	883	6.19e-11	58.9	CHB_VIBHA	N,N'-diacetylchitobiase (Chitobiase) (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (N-acetyl-beta-glucosaminidase)	Vibrio harveyi (Beneckea harveyi)	carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; glycosaminoglycan metabolic process [GO:0030203]	beta-N-acetylhexosaminidase activity [GO:0004563]; polysaccharide binding [GO:0030247]	cell outer membrane [GO:0009279]	GO:0004563; GO:0005975; GO:0006032; GO:0009279; GO:0030203; GO:0030247
GN020001	GN020001.1	Q86Z23	33.8	139	267	238	2.28e-11	65.5	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN020010	GN020010.1	V5NAL9	44.3	280	315	899	2.16e-70	237	TLR4_PINIB	Toll-like receptor 4 (PmTLR4)	Pinctada imbricata (Atlantic pearl-oyster) (Pinctada martensii)	signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0038023
GN020017	GN020017.1	Q95JJ0	37.5	323	382	350	2.50e-58	196	SG196_MACFA	Protein O-mannose kinase (POMK) (EC 2.7.1.183) (Protein kinase-like protein SgK196) (Sugen kinase 196)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	carbohydrate phosphorylation [GO:0046835]; protein O-linked glycosylation [GO:0006493]	ATP binding [GO:0005524]; carbohydrate kinase activity [GO:0019200]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; protein kinase activity [GO:0004672]	endoplasmic reticulum membrane [GO:0005789]	GO:0004672; GO:0005524; GO:0005789; GO:0006493; GO:0016773; GO:0019200; GO:0046835
GN020025	GN020025.1	Q6AZB8	36.2	276	291	349	2.21e-48	167	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN020027	GN020027.1	Q6AZB8	28.8	278	375	349	1.26e-28	117	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN020031	GN020031.1	Q17R06	50.6	162	217	222	2.84e-52	171	RAB21_BOVIN	Ras-related protein Rab-21 (EC 3.6.5.2)	Bos taurus (Bovine)	anterograde axonal transport [GO:0008089]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein stabilization [GO:0050821]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]	axon cytoplasm [GO:1904115]; cleavage furrow [GO:0032154]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0003924; GO:0003925; GO:0005525; GO:0005769; GO:0005789; GO:0005802; GO:0008089; GO:0009898; GO:0017157; GO:0019003; GO:0030659; GO:0031901; GO:0032154; GO:0032482; GO:0032580; GO:0048260; GO:0050775; GO:0050821; GO:0098559; GO:1904115; GO:2000643
GN020041	GN020041.1	Q8NHV1	32.6	215	334	300	2.19e-31	122	GIMA7_HUMAN	GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7)	Homo sapiens (Human)	GTP metabolic process [GO:0046039]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]	GO:0003924; GO:0005525; GO:0005783; GO:0005794; GO:0005811; GO:0042802; GO:0042803; GO:0046039
GN020042	GN020042.1	Q8R066	37.2	121	172	326	7.77e-12	65.5	C1QT4_MOUSE	Complement C1q tumor necrosis factor-related protein 4 (C1q/TNF-related protein 4)	Mus musculus (Mouse)	cell surface receptor signaling pathway via STAT [GO:0097696]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; macrophage activation [GO:0042116]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of tumor necrosis factor production [GO:0032760]; protein import [GO:0017038]; protein phosphorylation [GO:0006468]; reduction of food intake in response to dietary excess [GO:0002023]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; toll-like receptor 4 signaling pathway [GO:0034142]		extracellular region [GO:0005576]	GO:0002023; GO:0005576; GO:0006468; GO:0006954; GO:0009611; GO:0010467; GO:0017038; GO:0032496; GO:0032755; GO:0032760; GO:0034142; GO:0042116; GO:0070105; GO:0097696; GO:1901224
GN020045	GN020045.1	P0DN13	63.0	54	140	82	2.73e-20	82.0	VKT9_ANEVI	U-actitoxin-Avd3l (U-AITX-Avd3l) (AsKC9)	Anemonia viridis (Snakelocks anemone)		ion channel inhibitor activity [GO:0008200]; serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]; nematocyst [GO:0042151]	GO:0004867; GO:0005576; GO:0008200; GO:0042151
GN020046	GN020046.1	P23508	44.9	846	977	829	9.66e-144	452	CRCM_HUMAN	Colorectal mutant cancer protein (Protein MCC)	Homo sapiens (Human)	establishment of protein localization [GO:0045184]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; signal transduction [GO:0007165]	signaling receptor activity [GO:0038023]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0007165; GO:0010633; GO:0030027; GO:0038023; GO:0045184; GO:0050680; GO:0090090
GN020047	GN020047.1	Q8NHV1	27.8	205	312	300	3.20e-16	80.9	GIMA7_HUMAN	GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7)	Homo sapiens (Human)	GTP metabolic process [GO:0046039]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]	GO:0003924; GO:0005525; GO:0005783; GO:0005794; GO:0005811; GO:0042802; GO:0042803; GO:0046039
GN020048	GN020048.1	Q8NHV1	28.9	225	278	300	3.00e-18	85.9	GIMA7_HUMAN	GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7)	Homo sapiens (Human)	GTP metabolic process [GO:0046039]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]	GO:0003924; GO:0005525; GO:0005783; GO:0005794; GO:0005811; GO:0042802; GO:0042803; GO:0046039
GN020050	GN020050.1	Q6DFB7	30.5	616	591	572	1.02e-65	228	POC5_XENLA	Centrosomal protein POC5 (Protein of centriole 5)	Xenopus laevis (African clawed frog)	centriole elongation [GO:0061511]; eye photoreceptor cell development [GO:0042462]; negative regulation of centriole elongation [GO:1903723]		centriole [GO:0005814]; centrosome [GO:0005813]; photoreceptor connecting cilium [GO:0032391]	GO:0005813; GO:0005814; GO:0032391; GO:0042462; GO:0061511; GO:1903723
GN020053	GN020053.1	Q8CIZ5	46.8	126	353	1418	2.23e-27	117	DMBT1_RAT	Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Deleted in malignant brain tumors 1 protein) (Ebnerin) (Hensin) (Pancrin)	Rattus norvegicus (Rat)	antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; blastocyst development [GO:0001824]; cell differentiation [GO:0030154]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; inner cell mass cell proliferation [GO:0001833]; positive regulation of epithelial cell differentiation [GO:0030858]; receptor-mediated endocytosis [GO:0006898]; response to bacterium [GO:0009617]; response to biphenyl [GO:1904614]; response to estrogen [GO:0043627]; tissue regeneration [GO:0042246]	DNA binding [GO:0003677]; heparan sulfate binding [GO:1904399]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; pattern recognition receptor activity [GO:0038187]; scavenger receptor activity [GO:0005044]; zymogen binding [GO:0035375]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; phagocytic vesicle membrane [GO:0030670]; transport vesicle membrane [GO:0030658]; zymogen granule membrane [GO:0042589]	GO:0001530; GO:0001824; GO:0001833; GO:0003677; GO:0005044; GO:0005576; GO:0005737; GO:0006898; GO:0009617; GO:0030154; GO:0030658; GO:0030670; GO:0030858; GO:0031012; GO:0035375; GO:0038187; GO:0042246; GO:0042589; GO:0043627; GO:0050829; GO:0050830; GO:0061844; GO:0070891; GO:1904399; GO:1904614
GN020055	GN020055.1	A0A6I8TCE0	30.3	433	435	1309	7.78e-41	159	PTP1_AEDAE	Putative receptor-type tyrosine-protein phosphatase mosPTP-1 (mosPTP-1) (EC 3.1.3.48)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	anatomical structure morphogenesis [GO:0009653]; neuron development [GO:0048666]	protein tyrosine phosphatase activity [GO:0004725]	plasma membrane [GO:0005886]	GO:0004725; GO:0005886; GO:0009653; GO:0048666
GN020056	GN020056.1	Q6ZMT9	23.8	533	991	781	8.61e-23	108	DTHD1_HUMAN	Death domain-containing protein 1	Homo sapiens (Human)	signal transduction [GO:0007165]			GO:0007165
GN020057	GN020057.1	Q80UY1	54.3	357	377	400	2.13e-136	397	CARME_MOUSE	Protein-L-histidine N-pros-methyltransferase CARNMT1 (EC 2.1.1.-) (Carnosine N-methyltransferase) (EC 2.1.1.22)	Mus musculus (Mouse)	carnosine metabolic process [GO:0035498]	carnosine N-methyltransferase activity [GO:0030735]; protein homodimerization activity [GO:0042803]; protein-L-histidine N-pros-methyltransferase activity [GO:0106370]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0008757; GO:0030735; GO:0035498; GO:0042803; GO:0106370
GN020058	GN020058.1	Q5ZLW3	52.7	674	665	669	1.41e-233	666	DYM_CHICK	Dymeclin	Gallus gallus (Chicken)	Golgi organization [GO:0007030]		Golgi apparatus [GO:0005794]	GO:0005794; GO:0007030
GN020059	GN020059.1	P33015	23.6	352	421	352	1.53e-09	62.8	TSUA_ECOLI	Thiosulfate transporter TsuA (Thiosulfate uptake protein A)	Escherichia coli (strain K12)	thiosulfate transport [GO:0015709]	thiosulfate transmembrane transporter activity [GO:0015117]	plasma membrane [GO:0005886]	GO:0005886; GO:0015117; GO:0015709
GN020061	GN020061.1	Q9W2Q5	39.6	192	186	189	2.77e-39	135	CIB2_DROME	Calcium and integrin-binding family member 2	Drosophila melanogaster (Fruit fly)	calcium ion homeostasis [GO:0055074]; phototransduction [GO:0007602]	calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]	cytoplasm [GO:0005737]	GO:0000287; GO:0005509; GO:0005737; GO:0007602; GO:0055074
GN020063	GN020063.1	Q9QZN1	40.2	376	837	701	2.80e-36	150	FXL17_MOUSE	F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13)	Mus musculus (Mouse)	nervous system development [GO:0007399]; neural crest cell differentiation [GO:0014033]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; protein ubiquitination [GO:0016567]; regulation of smoothened signaling pathway [GO:0008589]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]		cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]	GO:0000209; GO:0005634; GO:0005654; GO:0005737; GO:0006515; GO:0007399; GO:0008589; GO:0014033; GO:0016567; GO:0019005; GO:0031146; GO:0043161
GN020064	GN020064.1	Q05733	63.4	552	693	847	2.62e-252	722	DCHS_DROME	Histidine decarboxylase (HDC) (EC 4.1.1.22)	Drosophila melanogaster (Fruit fly)	histamine biosynthetic process [GO:0001694]; L-histidine catabolic process [GO:0006548]; thermotaxis [GO:0043052]	histidine decarboxylase activity [GO:0004398]; pyridoxal phosphate binding [GO:0030170]	extrinsic component of synaptic vesicle membrane [GO:0098850]	GO:0001694; GO:0004398; GO:0006548; GO:0030170; GO:0043052; GO:0098850
GN020067	GN020067.1	Q9Y617	62.9	364	373	370	7.07e-168	476	SERC_HUMAN	Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT)	Homo sapiens (Human)	L-serine biosynthetic process [GO:0006564]; negative regulation of ferroptosis [GO:0110076]; pyridoxine biosynthetic process [GO:0008615]	identical protein binding [GO:0042802]; O-phospho-L-serine:2-oxoglutarate transaminase activity [GO:0004648]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0004648; GO:0005829; GO:0006564; GO:0008615; GO:0042802; GO:0070062; GO:0110076
GN020068	GN020068.1	O43396	53.1	286	288	289	4.31e-106	313	TXNL1_HUMAN	Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein)	Homo sapiens (Human)		disulfide oxidoreductase activity [GO:0015036]; protein-disulfide reductase activity [GO:0015035]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005829; GO:0015035; GO:0015036
GN020069	GN020069.1	Q9Y6R7	27.3	319	547	5405	6.81e-17	88.6	FCGBP_HUMAN	IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP)	Homo sapiens (Human)		extracellular matrix structural constituent [GO:0005201]	extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; Golgi lumen [GO:0005796]	GO:0005201; GO:0005796; GO:0031012; GO:0070062
GN020071	GN020071.1	Q9D799	42.0	326	476	386	3.22e-73	239	FMT_MOUSE	Methionyl-tRNA formyltransferase, mitochondrial (MtFMT) (EC 2.1.2.9)	Mus musculus (Mouse)	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [GO:0071951]	methionyl-tRNA formyltransferase activity [GO:0004479]	mitochondrion [GO:0005739]	GO:0004479; GO:0005739; GO:0071951
GN020072	GN020072.1	Q3MHP2	67.9	156	269	218	1.50e-72	224	RB11B_BOVIN	Ras-related protein Rab-11B (EC 3.6.5.2)	Bos taurus (Bovine)	amyloid-beta clearance by transcytosis [GO:0150093]; cellular response to acidic pH [GO:0071468]; constitutive secretory pathway [GO:0045054]; endocytic recycling [GO:0032456]; establishment of protein localization to membrane [GO:0090150]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; melanosome transport [GO:0032402]; receptor recycling [GO:0001881]; regulated exocytosis [GO:0045055]; regulation of cilium assembly [GO:1902017]; regulation of endocytic recycling [GO:2001135]; regulation of monoatomic anion transport [GO:0044070]; regulation of protein localization to cell surface [GO:2000008]; transferrin transport [GO:0033572]	G protein activity [GO:0003925]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]	cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]	GO:0001881; GO:0003924; GO:0003925; GO:0005525; GO:0005794; GO:0008021; GO:0019003; GO:0030670; GO:0030672; GO:0031410; GO:0031489; GO:0032402; GO:0032456; GO:0033572; GO:0035773; GO:0044070; GO:0045054; GO:0045055; GO:0045335; GO:0055037; GO:0055038; GO:0071468; GO:0090150; GO:0150093; GO:1902017; GO:2000008; GO:2001135
GN020073	GN020073.1	Q5R7S6	37.6	165	183	208	1.27e-12	66.6	ZFAN6_PONAB	AN1-type zinc finger protein 6 (Zinc finger A20 domain-containing protein 3)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; protein targeting to peroxisome [GO:0006625]; regulation of canonical NF-kappaB signal transduction [GO:0043122]	DNA binding [GO:0003677]; polyubiquitin modification-dependent protein binding [GO:0031593]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0003677; GO:0005737; GO:0006625; GO:0008270; GO:0031593; GO:0043066; GO:0043122; GO:0071356
GN020074	GN020074.1	Q28C98	69.3	140	149	179	1.62e-61	190	MESH1_XENTR	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)		guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity [GO:0008893]		GO:0008893
GN020075	GN020075.1	Q9JMG7	67.0	91	968	202	3.41e-37	142	HDGR3_MOUSE	Hepatoma-derived growth factor-related protein 3 (HRP-3)	Mus musculus (Mouse)	microtubule polymerization [GO:0046785]; negative regulation of microtubule depolymerization [GO:0007026]; neuron projection development [GO:0031175]	chromatin binding [GO:0003682]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007026; GO:0008017; GO:0015631; GO:0031175; GO:0046785
GN020076	GN020076.1	P0C546	60.8	288	347	318	7.91e-114	336	S2542_RAT	Mitochondrial coenzyme A transporter SLC25A42 (Solute carrier family 25 member 42)	Rattus norvegicus (Rat)	ADP transport [GO:0015866]; AMP transport [GO:0080121]; ATP transport [GO:0015867]; coenzyme A transmembrane transport [GO:0035349]; mitochondrial coenzyme A transmembrane transport [GO:1990559]	ADP phosphatase activity [GO:0043262]; ADP transmembrane transporter activity [GO:0015217]; AMP transmembrane transporter activity [GO:0080122]; ATP transmembrane transporter activity [GO:0005347]; ATP:ADP antiporter activity [GO:0005471]; coenzyme A transmembrane transporter activity [GO:0015228]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005347; GO:0005471; GO:0005739; GO:0005743; GO:0015217; GO:0015228; GO:0015866; GO:0015867; GO:0035349; GO:0043262; GO:0080121; GO:0080122; GO:1990559
GN020077	GN020077.1	Q15262	30.9	530	554	1439	2.43e-75	263	PTPRK_HUMAN	Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)	Homo sapiens (Human)	cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]	beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; organelle [GO:0043226]; plasma membrane [GO:0005886]	GO:0004725; GO:0005001; GO:0005886; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016020; GO:0016477; GO:0019901; GO:0030054; GO:0030336; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043226; GO:0045295; GO:0045786; GO:0045892; GO:0048041
GN020078	GN020078.1	Q15262	30.9	530	554	1439	7.03e-74	259	PTPRK_HUMAN	Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)	Homo sapiens (Human)	cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of keratinocyte proliferation [GO:0010839]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]	beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	adherens junction [GO:0005912]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; organelle [GO:0043226]; plasma membrane [GO:0005886]	GO:0004725; GO:0005001; GO:0005886; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016020; GO:0016477; GO:0019901; GO:0030054; GO:0030336; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043226; GO:0045295; GO:0045786; GO:0045892; GO:0048041
GN020080	GN020080.1	Q9NS40	58.2	445	715	1196	2.13e-168	518	KCNH7_HUMAN	Voltage-gated inwardly rectifying potassium channel KCNH7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (hERG-3) (Potassium voltage-gated channel subfamily H member 7) (Voltage-gated potassium channel subunit Kv11.3)	Homo sapiens (Human)	potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]	heme binding [GO:0020037]; inward rectifier potassium channel activity [GO:0005242]	plasma membrane [GO:0005886]	GO:0005242; GO:0005886; GO:0006813; GO:0020037; GO:0042391; GO:0071805
GN020083	GN020083.1	Q7ZUP0	65.8	155	227	254	9.30e-61	194	AN32A_DANRE	Acidic leucine-rich nuclear phosphoprotein 32 family member A	Danio rerio (Zebrafish) (Brachydanio rerio)	nucleocytoplasmic transport [GO:0006913]; regulation of apoptotic process [GO:0042981]	histone binding [GO:0042393]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0005634; GO:0005737; GO:0005783; GO:0006913; GO:0042393; GO:0042981; GO:0048471
GN020088	GN020088.1	Q13490	50.9	55	715	618	1.15e-10	68.6	BIRC2_HUMAN	Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)	Homo sapiens (Human)	canonical NF-kappaB signal transduction [GO:0007249]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; non-canonical NF-kappaB signal transduction [GO:0038061]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; positive regulation of protein ubiquitination [GO:0031398]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; response to bleomycin [GO:1904975]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; FBXO family protein binding [GO:0098770]; identical protein binding [GO:0042802]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transcription coactivator activity [GO:0003713]; transferase activity [GO:0016740]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	CD40 receptor complex [GO:0035631]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; survivin complex [GO:1990713]; tumor necrosis factor receptor superfamily complex [GO:0002947]; XY body [GO:0001741]	GO:0000209; GO:0001666; GO:0001741; GO:0002947; GO:0003713; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006954; GO:0007166; GO:0007249; GO:0008270; GO:0008625; GO:0008630; GO:0009898; GO:0016740; GO:0031398; GO:0033209; GO:0034121; GO:0035631; GO:0038061; GO:0039535; GO:0042127; GO:0042802; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043130; GO:0043161; GO:0044877; GO:0045088; GO:0045471; GO:0045595; GO:0050727; GO:0051087; GO:0051591; GO:0051726; GO:0060544; GO:0060546; GO:0061630; GO:0070266; GO:0070424; GO:0098770; GO:1902523; GO:1902524; GO:1902527; GO:1904975; GO:1990713
GN020089	GN020089.1	P40305	46.1	89	308	122	7.04e-10	59.3	IFI27_HUMAN	Interferon alpha-inducible protein 27, mitochondrial (p27) (Interferon alpha-induced 11.5 kDa protein) (Interferon-stimulated gene 12a protein) (ISG12(a)) (ISG12A)	Homo sapiens (Human)	apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; host-mediated perturbation of viral genome replication [GO:0044827]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of transcription by RNA polymerase II [GO:0000122]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; pyroptotic inflammatory response [GO:0070269]; regulation of protein export from nucleus [GO:0046825]; type I interferon-mediated signaling pathway [GO:0060337]	identical protein binding [GO:0042802]; lamin binding [GO:0005521]; molecular adaptor activity [GO:0060090]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	endoplasmic reticulum membrane [GO:0005789]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]	GO:0000122; GO:0005521; GO:0005635; GO:0005637; GO:0005739; GO:0005741; GO:0005789; GO:0006915; GO:0031966; GO:0042802; GO:0043161; GO:0044827; GO:0045087; GO:0046825; GO:0051607; GO:0060090; GO:0060337; GO:0061629; GO:0070269; GO:0070936; GO:0097191; GO:0097193
GN020090	GN020090.1	P55814	48.6	105	124	216	2.65e-33	118	OAZ1_XENLA	Ornithine decarboxylase antizyme 1 (ODC-Az)	Xenopus laevis (African clawed frog)	positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein catabolic process [GO:0045732]	ornithine decarboxylase inhibitor activity [GO:0008073]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0008073; GO:0045732; GO:0090316
GN020093	GN020093.1	Q6TDP3	28.0	232	608	640	4.00e-20	98.2	KLH17_MOUSE	Kelch-like protein 17 (Actinfilin)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]	actin filament binding [GO:0051015]; molecular adaptor activity [GO:0060090]; POZ domain binding [GO:0031208]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	actin cytoskeleton [GO:0015629]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; dendrite cytoplasm [GO:0032839]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; synapse [GO:0045202]	GO:0005737; GO:0014069; GO:0015629; GO:0016567; GO:0030036; GO:0031208; GO:0031463; GO:0032839; GO:0043025; GO:0043161; GO:0045202; GO:0051015; GO:0060090; GO:0098794; GO:0098978; GO:0140252; GO:1990756
GN020094	GN020094.1	P18433	23.3	632	997	802	4.72e-32	138	PTPRA_HUMAN	Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)	Homo sapiens (Human)	integrin-mediated signaling pathway [GO:0007229]; regulation of focal adhesion assembly [GO:0051893]; signal transduction [GO:0007165]	protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]	extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0004725; GO:0005001; GO:0005886; GO:0005925; GO:0007165; GO:0007229; GO:0016020; GO:0043235; GO:0051893; GO:0070062
GN020095	GN020095.1	A8TX70	28.8	612	626	2615	2.62e-57	213	CO6A5_HUMAN	Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4)	Homo sapiens (Human)	extracellular matrix organization [GO:0030198]	extracellular matrix structural constituent conferring tensile strength [GO:0030020]	collagen type VI trimer [GO:0005589]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005576; GO:0005589; GO:0030020; GO:0030198; GO:0031012
GN020098	GN020098.1	P14316	49.6	123	822	349	8.07e-34	136	IRF2_HUMAN	Interferon regulatory factor 2 (IRF-2)	Homo sapiens (Human)	cell population proliferation [GO:0008283]; defense response to virus [GO:0051607]; immune system process [GO:0002376]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type I interferon production [GO:0032480]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; toll-like receptor 3 signaling pathway [GO:0034138]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]	cell junction [GO:0030054]; chromatin [GO:0000785]; chromosome [GO:0005694]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000977; GO:0000978; GO:0000981; GO:0001227; GO:0001228; GO:0002376; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0006355; GO:0006357; GO:0008283; GO:0030054; GO:0032480; GO:0034138; GO:0043565; GO:0045944; GO:0051607; GO:1990837
GN020099	GN020099.1	P80912	70.6	126	126	126	1.84e-66	199	HINT1_RABIT	Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (P13.7)	Oryctolagus cuniculus (Rabbit)	intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; protein desumoylation [GO:0016926]; purine ribonucleotide catabolic process [GO:0009154]; regulation of DNA-templated transcription [GO:0006355]	adenosine 5'-monophosphoramidase activity [GO:0043530]; deSUMOylase activity [GO:0016929]; hydrolase activity [GO:0016787]	cytoplasm [GO:0005737]; histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]	GO:0000118; GO:0005634; GO:0005737; GO:0006355; GO:0009154; GO:0016787; GO:0016926; GO:0016929; GO:0043530; GO:0072332
GN020100	GN020100.1	P22600	69.7	347	366	416	5.16e-177	501	HEMH_BOVIN	Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase)	Bos taurus (Bovine)	heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]	iron ion binding [GO:0005506]; protoporphyrin ferrochelatase activity [GO:0004325]	mitochondrial inner membrane [GO:0005743]	GO:0004325; GO:0005506; GO:0005743; GO:0006783; GO:0006785
GN020102	GN020102.1	P22600	69.7	347	366	416	5.16e-177	501	HEMH_BOVIN	Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase)	Bos taurus (Bovine)	heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]	iron ion binding [GO:0005506]; protoporphyrin ferrochelatase activity [GO:0004325]	mitochondrial inner membrane [GO:0005743]	GO:0004325; GO:0005506; GO:0005743; GO:0006783; GO:0006785
GN020105	GN020105.1	Q059Y8	28.5	694	750	732	1.45e-77	267	DCST1_MOUSE	E3 ubiquitin-protein ligase DCST1 (EC 2.3.2.27) (DC-STAMP domain-containing protein 1) (RING-type E3 ubiquitin transferase)	Mus musculus (Mouse)	fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein ubiquitination [GO:0016567]; sperm-egg recognition [GO:0035036]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]	acrosomal membrane [GO:0002080]; plasma membrane [GO:0005886]	GO:0002080; GO:0005886; GO:0006511; GO:0007342; GO:0016567; GO:0035036; GO:0060339; GO:0061630
GN020106	GN020106.1	Q8NDA2	31.8	157	344	5079	4.09e-12	71.2	HMCN2_HUMAN	Hemicentin-2	Homo sapiens (Human)	homophilic cell-cell adhesion [GO:0007156]; synapse organization [GO:0050808]	axon guidance receptor activity [GO:0008046]; calcium ion binding [GO:0005509]	axon [GO:0030424]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; extracellular matrix [GO:0031012]; neuronal cell body [GO:0043025]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005938; GO:0007156; GO:0008046; GO:0030054; GO:0030424; GO:0031012; GO:0032154; GO:0043025; GO:0050808; GO:0140144
GN020109	GN020109.1	Q8NDA2	29.0	366	633	5079	6.32e-30	130	HMCN2_HUMAN	Hemicentin-2	Homo sapiens (Human)	homophilic cell-cell adhesion [GO:0007156]; synapse organization [GO:0050808]	axon guidance receptor activity [GO:0008046]; calcium ion binding [GO:0005509]	axon [GO:0030424]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; extracellular matrix [GO:0031012]; neuronal cell body [GO:0043025]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005509; GO:0005886; GO:0005938; GO:0007156; GO:0008046; GO:0030054; GO:0030424; GO:0031012; GO:0032154; GO:0043025; GO:0050808; GO:0140144
GN020110	GN020110.1	Q76NT9	28.8	313	355	368	8.80e-24	103	ACCO1_DICDI	1-aminocyclopropane-1-carboxylate oxidase (ACC oxidase) (Ddaco) (EC 1.14.17.4) (Ethylene-forming enzyme) (EFE)	Dictyostelium discoideum (Social amoeba)	ethylene biosynthetic process [GO:0009693]	1-aminocyclopropane-1-carboxylate oxidase activity [GO:0009815]		GO:0009693; GO:0009815
GN020111	GN020111.1	Q76NT9	28.8	313	347	368	7.68e-24	103	ACCO1_DICDI	1-aminocyclopropane-1-carboxylate oxidase (ACC oxidase) (Ddaco) (EC 1.14.17.4) (Ethylene-forming enzyme) (EFE)	Dictyostelium discoideum (Social amoeba)	ethylene biosynthetic process [GO:0009693]	1-aminocyclopropane-1-carboxylate oxidase activity [GO:0009815]		GO:0009693; GO:0009815
GN020113	GN020113.1	Q09325	44.1	68	72	447	3.42e-18	79.7	MGAT1_RAT	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (GNT-I) (GlcNAc-T I)	Rattus norvegicus (Rat)	galactose catabolic process via UDP-galactose, Leloir pathway [GO:0033499]; in utero embryonic development [GO:0001701]; protein N-linked glycosylation [GO:0006487]	acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0003827]; manganese ion binding [GO:0030145]	Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]	GO:0000139; GO:0001701; GO:0003827; GO:0006487; GO:0008375; GO:0030145; GO:0033499; GO:0048471
GN020118	GN020118.1	P15144	41.1	923	1003	967	4.85e-244	717	AMPN_HUMAN	Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13)	Homo sapiens (Human)	angiotensin maturation [GO:0002003]; peptide catabolic process [GO:0043171]	alanyl aminopeptidase activity [GO:0016285]; aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237]; signaling receptor activity [GO:0038023]; zinc ion binding [GO:0008270]	endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]	GO:0002003; GO:0004177; GO:0005576; GO:0005765; GO:0005793; GO:0005886; GO:0008237; GO:0008270; GO:0009897; GO:0016285; GO:0030667; GO:0038023; GO:0043171; GO:0070006; GO:0070062
GN020121	GN020121.1	Q9UBM8	39.6	318	328	478	1.03e-63	212	MGT4C_HUMAN	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-acetylglucosaminyltransferase IV homolog) (hGnT-IV-H) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GlcNAc-T IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)	Homo sapiens (Human)	protein N-linked glycosylation [GO:0006487]; viral protein processing [GO:0019082]	acetylglucosaminyltransferase activity [GO:0008375]; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity [GO:0008454]	Golgi membrane [GO:0000139]	GO:0000139; GO:0006487; GO:0008375; GO:0008454; GO:0019082
GN020135	GN020135.1	Q708S3	28.4	426	480	558	2.03e-39	153	ASI4B_DANRE	Acid-sensing ion channel 4-B (ASIC4-B) (Acid-sensing ion channel 4.2) (Amiloride-sensitive cation channel 4-B) (ZASIC4.2)	Danio rerio (Zebrafish) (Brachydanio rerio)	response to steroid hormone [GO:0048545]; sodium ion transmembrane transport [GO:0035725]	monoatomic cation channel activity [GO:0005261]; sodium channel activity [GO:0005272]	plasma membrane [GO:0005886]	GO:0005261; GO:0005272; GO:0005886; GO:0035725; GO:0048545
GN020144	GN020144.1	Q01177	48.2	166	162	812	2.08e-47	167	PLMN_RAT	Plasminogen [Cleaved into: Plasmin (EC 3.4.21.7); Plasmin heavy chain A; Plasmin light chain B; Angiostatin]	Rattus norvegicus (Rat)	blood coagulation [GO:0007596]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; fibrinolysis [GO:0042730]; labyrinthine layer blood vessel development [GO:0060716]; mononuclear cell migration [GO:0071674]; muscle cell cellular homeostasis [GO:0046716]; myoblast differentiation [GO:0045445]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of fibrinolysis [GO:0051919]; protein catabolic process [GO:0030163]; protein processing [GO:0016485]; proteolysis [GO:0006508]; tissue regeneration [GO:0042246]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]; trophoblast giant cell differentiation [GO:0060707]	apolipoprotein binding [GO:0034185]; endopeptidase activity [GO:0004175]; enzyme binding [GO:0019899]; kinase binding [GO:0019900]; protease binding [GO:0002020]; protein antigen binding [GO:1990405]; protein domain specific binding [GO:0019904]; protein-folding chaperone binding [GO:0051087]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0002020; GO:0004175; GO:0004252; GO:0005102; GO:0005576; GO:0006508; GO:0007596; GO:0009897; GO:0009986; GO:0010812; GO:0016485; GO:0019899; GO:0019900; GO:0019904; GO:0022617; GO:0030163; GO:0030574; GO:0034185; GO:0042246; GO:0042730; GO:0043536; GO:0045445; GO:0046716; GO:0051087; GO:0051918; GO:0051919; GO:0060707; GO:0060716; GO:0071674; GO:0098685; GO:0098978; GO:0099183; GO:1990405
GN020145	GN020145.1	Q16878	45.5	165	194	200	1.51e-43	147	CDO1_HUMAN	Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I)	Homo sapiens (Human)	L-cysteine catabolic process [GO:0019448]; lactation [GO:0007595]; response to amino acid [GO:0043200]; response to azide [GO:0097184]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to glucocorticoid [GO:0051384]; taurine biosynthetic process [GO:0042412]	cysteine dioxygenase activity [GO:0017172]; ferrous iron binding [GO:0008198]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]	GO:0005829; GO:0007595; GO:0008198; GO:0008270; GO:0016151; GO:0017172; GO:0019448; GO:0033762; GO:0042412; GO:0043200; GO:0045471; GO:0051384; GO:0051591; GO:0097184
GN020148	GN020148.1	P34456	28.6	161	172	419	2.59e-16	78.6	YMD2_CAEEL	Uncharacterized protein F54H12.2	Caenorhabditis elegans	deoxyribonucleotide biosynthetic process [GO:0009263]	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]	cytosol [GO:0005829]	GO:0004748; GO:0005829; GO:0009263
GN020150	GN020150.1	D8VNS7	41.2	216	337	345	3.32e-50	173	FCNV1_CERRY	Ryncolin-1	Cerberus rynchops (Dog-faced water snake)	complement activation, lectin pathway [GO:0001867]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; signaling receptor binding [GO:0005102]	extracellular region [GO:0005576]	GO:0001867; GO:0003823; GO:0005102; GO:0005576; GO:0097367
GN020154	GN020154.1	Q8TC07	26.9	450	644	691	6.19e-42	165	TBC15_HUMAN	TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP)	Homo sapiens (Human)	regulation of GTPase activity [GO:0043087]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]	GO:0005096; GO:0005576; GO:0005737; GO:0005739; GO:0005829; GO:0043087
GN020156	GN020156.1	Q92122	67.1	520	610	527	1.47e-252	707	KPYM_XENLA	Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP)	Xenopus laevis (African clawed frog)	cellular response to insulin stimulus [GO:0032869]; glycolytic process [GO:0006096]	magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743]		GO:0000287; GO:0004743; GO:0006096; GO:0030955; GO:0032869
GN020158	GN020158.1	Q5SUV2	33.2	735	1439	932	1.82e-94	330	MYBPP_MOUSE	MYCBP-associated protein (AMAM-1) (AMY-1-binding protein 1) (AMAP-1)	Mus musculus (Mouse)	acrosome assembly [GO:0001675]; chemical synaptic transmission [GO:0007268]; flagellated sperm motility [GO:0030317]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283]		acrosomal vesicle [GO:0001669]; axonemal central apparatus [GO:1990716]; cytoplasm [GO:0005737]; membrane [GO:0016020]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; synapse [GO:0045202]	GO:0001669; GO:0001675; GO:0005737; GO:0007268; GO:0007283; GO:0016020; GO:0030317; GO:0036126; GO:0045202; GO:0097225; GO:0120316; GO:1990716
GN020159	GN020159.1	Q90683	78.9	76	365	85	3.44e-28	108	ITF2_CHICK	Transcription factor 4 (TCF-4) (Class A helix-loop-helix transcription factor GE2)	Gallus gallus (Chicken)	positive regulation of neuron differentiation [GO:0045666]	E-box binding [GO:0070888]; protein heterodimerization activity [GO:0046982]	nucleus [GO:0005634]	GO:0005634; GO:0045666; GO:0046982; GO:0070888
GN020160	GN020160.1	Q5M8C6	37.4	219	323	314	5.61e-41	148	FGL1_RAT	Fibrinogen-like protein 1	Rattus norvegicus (Rat)	adipose tissue development [GO:0060612]; blood coagulation [GO:0007596]; cholesterol metabolic process [GO:0008203]; hepatocyte proliferation [GO:0072574]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; regulation of glucose metabolic process [GO:0010906]; regulation of immune response [GO:0050776]; response to stilbenoid [GO:0035634]	identical protein binding [GO:0042802]; receptor ligand activity [GO:0048018]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005576; GO:0005886; GO:0007596; GO:0008203; GO:0010906; GO:0031012; GO:0035634; GO:0042802; GO:0048018; GO:0050776; GO:0050860; GO:0050868; GO:0060612; GO:0072574
GN020161	GN020161.1	Q0IHV1	30.3	152	148	1380	6.23e-10	59.7	INF2_XENTR	Inverted formin-2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	actin cytoskeleton organization [GO:0030036]	actin binding [GO:0003779]; small GTPase binding [GO:0031267]		GO:0003779; GO:0030036; GO:0031267
GN020162	GN020162.1	Q6NTV6	33.4	431	477	1099	1.66e-68	240	INF2_XENLA	Inverted formin-2	Xenopus laevis (African clawed frog)	actin cytoskeleton organization [GO:0030036]	actin binding [GO:0003779]; small GTPase binding [GO:0031267]		GO:0003779; GO:0030036; GO:0031267
GN020164	GN020164.1	Q90610	24.4	626	1331	1443	5.03e-34	146	NEO1_CHICK	Neogenin	Gallus gallus (Chicken)	axon guidance [GO:0007411]; cell-cell adhesion [GO:0098609]; neuron migration [GO:0001764]		cell surface [GO:0009986]; plasma membrane [GO:0005886]	GO:0001764; GO:0005886; GO:0007411; GO:0009986; GO:0098609
GN020165	GN020165.1	Q5C9L6	38.8	299	328	361	1.72e-69	223	CNMT_THLFG	(S)-coclaurine N-methyltransferase (TfCNMT) (EC 2.1.1.140)	Thalictrum flavum subsp. glaucum (Yellow meadow rue)		(S)-coclaurine-N-methyltransferase activity [GO:0030794]	cytoplasm [GO:0005737]	GO:0005737; GO:0030794
GN020166	GN020166.1	Q9XTQ6	30.4	296	563	657	4.30e-37	149	TBH1_CAEEL	Tyramine beta-hydroxylase (EC 1.14.17.-) (Tyramine beta-monooxygenase) (TbetaM)	Caenorhabditis elegans	octopamine biosynthetic process [GO:0006589]	copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; tyramine-beta hydroxylase activity [GO:0004836]	secretory granule membrane [GO:0030667]; synapse [GO:0045202]	GO:0004500; GO:0004836; GO:0005507; GO:0006589; GO:0030667; GO:0045202
GN020168	GN020168.1	Q5TZ24	29.8	245	282	614	2.67e-22	99.8	MOXD1_DANRE	DBH-like monooxygenase protein 1 homolog (EC 1.14.17.-)	Danio rerio (Zebrafish) (Brachydanio rerio)		copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [GO:0016715]	endoplasmic reticulum membrane [GO:0005789]; secretory granule membrane [GO:0030667]	GO:0004500; GO:0005507; GO:0005789; GO:0016715; GO:0030667
GN020170	GN020170.1	Q4PZA2	38.1	741	807	769	8.18e-172	517	ECE1_MOUSE	Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)	Mus musculus (Mouse)	axon guidance [GO:0007411]; axonogenesis involved in innervation [GO:0060385]; blood vessel diameter maintenance [GO:0097746]; bradykinin catabolic process [GO:0010815]; calcitonin catabolic process [GO:0010816]; ear development [GO:0043583]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube development [GO:0035050]; endothelin maturation [GO:0034959]; gene expression [GO:0010467]; heart development [GO:0007507]; hormone catabolic process [GO:0042447]; neuron projection development [GO:0031175]; peptide hormone processing [GO:0016486]; pharyngeal system development [GO:0060037]; positive regulation of cAMP/PKA signal transduction [GO:0141163]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of receptor recycling [GO:0001921]; protein processing [GO:0016485]; regulation of blood pressure [GO:0008217]; regulation of ERK1 and ERK2 cascade [GO:0070372]; response to hypoxia [GO:0001666]; semaphorin-plexin signaling pathway [GO:0071526]; substance P catabolic process [GO:0010814]; sympathetic neuron axon guidance [GO:0097492]	endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	cell surface [GO:0009986]; early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093]	GO:0001666; GO:0001921; GO:0004175; GO:0004222; GO:0005768; GO:0005769; GO:0005794; GO:0005886; GO:0007411; GO:0007507; GO:0008217; GO:0008233; GO:0008270; GO:0009897; GO:0009986; GO:0010467; GO:0010613; GO:0010814; GO:0010815; GO:0010816; GO:0016020; GO:0016485; GO:0016486; GO:0030141; GO:0031175; GO:0031982; GO:0033093; GO:0034959; GO:0035050; GO:0042447; GO:0042733; GO:0042802; GO:0042803; GO:0043583; GO:0045745; GO:0048471; GO:0060037; GO:0060385; GO:0070372; GO:0071526; GO:0097492; GO:0097746; GO:0141163
GN020172	GN020172.1	Q9VCA2	28.2	522	528	548	6.17e-53	191	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN020175	GN020175.1	Q5VWW1	35.7	140	148	255	2.56e-14	70.9	C1QL3_HUMAN	Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0097107; GO:0098686; GO:0098978; GO:0099550; GO:0099558; GO:0099645
GN020176	GN020176.1	Q9WTS8	49.7	153	197	335	2.11e-45	155	FCN1_RAT	Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)	Rattus norvegicus (Rat)	cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of interleukin-8 production [GO:0032757]	antigen binding [GO:0003823]; carbohydrate derivative binding [GO:0097367]; pattern recognition receptor activity [GO:0038187]; sialic acid binding [GO:0033691]; signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; symbiont cell surface [GO:0106139]	GO:0001867; GO:0002752; GO:0003823; GO:0005102; GO:0005576; GO:0005886; GO:0007186; GO:0009986; GO:0031012; GO:0032757; GO:0033691; GO:0038187; GO:0097367; GO:0106139
GN020180	GN020180.1	Q8N6V9	37.3	373	423	391	6.04e-38	144	TEX9_HUMAN	Testis-expressed protein 9	Homo sapiens (Human)			centriolar satellite [GO:0034451]	GO:0034451
GN020183	GN020183.1	Q9ERE8	33.3	315	434	362	9.08e-48	170	TLRN1_MOUSE	Talin rod domain-containing protein 1 (Mesoderm development candidate 1)	Mus musculus (Mouse)		actin binding [GO:0003779]; identical protein binding [GO:0042802]		GO:0003779; GO:0042802
GN020184	GN020184.1	P81069	84.9	73	521	414	3.28e-32	131	GABP2_MOUSE	GA-binding protein subunit beta-2 (GABP subunit beta-2) (GABPB-2) (GA-binding protein beta-2-1) (GABP subunit beta-2-1) (GABPB2-1)	Mus musculus (Mouse)	positive regulation of transcription by RNA polymerase II [GO:0045944]	identical protein binding [GO:0042802]; transcription cis-regulatory region binding [GO:0000976]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000976; GO:0005634; GO:0005654; GO:0042802; GO:0045944
GN020185	GN020185.1	Q8BZH4	37.8	378	1492	1409	3.49e-36	154	POGZ_MOUSE	Pogo transposable element with ZNF domain	Mus musculus (Mouse)	double-strand break repair via homologous recombination [GO:0000724]; kinetochore assembly [GO:0051382]; mitotic sister chromatid cohesion [GO:0007064]; regulation of DNA-templated transcription [GO:0006355]	DNA-binding transcription factor activity [GO:0003700]; transcription cis-regulatory region binding [GO:0000976]	chromatin [GO:0000785]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0000724; GO:0000785; GO:0000976; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006355; GO:0007064; GO:0036064; GO:0051382
GN020188	GN020188.1	Q8BNX1	28.9	142	239	294	1.01e-14	75.1	CLC4G_MOUSE	C-type lectin domain family 4 member G	Mus musculus (Mouse)	immune response [GO:0006955]; negative regulation of T cell mediated immunity [GO:0002710]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of viral life cycle [GO:1903902]; symbiont entry into host cell [GO:0046718]	carbohydrate binding [GO:0030246]; carbohydrate derivative binding [GO:0097367]; D-mannose binding [GO:0005537]; fructose binding [GO:0070061]; pattern recognition receptor activity [GO:0038187]; polysaccharide binding [GO:0030247]; virus coreceptor activity [GO:0120274]; virus receptor activity [GO:0001618]	external side of plasma membrane [GO:0009897]; plasma membrane [GO:0005886]	GO:0001618; GO:0002710; GO:0005537; GO:0005886; GO:0006955; GO:0009897; GO:0030246; GO:0030247; GO:0038187; GO:0042130; GO:0046718; GO:0070061; GO:0097367; GO:0120274; GO:1903902
GN020193	GN020193.1	O88967	48.0	496	639	715	9.18e-145	440	YMEL1_MOUSE	ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (EC 3.6.-.-) (ATP-dependent metalloprotease FtsH1) (YME1-like protein 1)	Mus musculus (Mouse)	cell population proliferation [GO:0008283]; cellular response to starvation [GO:0009267]; mitochondrial protein catabolic process [GO:0035694]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of mitochondrial fusion [GO:0010636]; protein hexamerization [GO:0034214]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of stem cell division [GO:2000035]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent peptidase activity [GO:0004176]; metalloendopeptidase activity [GO:0004222]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]	GO:0004176; GO:0004222; GO:0005524; GO:0005739; GO:0005743; GO:0006515; GO:0007005; GO:0008283; GO:0009267; GO:0010636; GO:0016604; GO:0016887; GO:0034214; GO:0034982; GO:0035694; GO:0043066; GO:0097150; GO:2000035
GN020197	GN020197.1	Q16878	46.3	162	197	200	1.04e-44	150	CDO1_HUMAN	Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I)	Homo sapiens (Human)	L-cysteine catabolic process [GO:0019448]; lactation [GO:0007595]; response to amino acid [GO:0043200]; response to azide [GO:0097184]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to glucocorticoid [GO:0051384]; taurine biosynthetic process [GO:0042412]	cysteine dioxygenase activity [GO:0017172]; ferrous iron binding [GO:0008198]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]	GO:0005829; GO:0007595; GO:0008198; GO:0008270; GO:0016151; GO:0017172; GO:0019448; GO:0033762; GO:0042412; GO:0043200; GO:0045471; GO:0051384; GO:0051591; GO:0097184
GN020198	GN020198.1	Q96FB5	32.1	577	584	475	2.29e-75	250	MT25B_HUMAN	Methyltransferase-like protein 25B (Protein RRNAD1) (Ribosomal RNA adenine dimethylase domain-containing protein 1)	Homo sapiens (Human)	rRNA modification [GO:0000154]	rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]	membrane [GO:0016020]	GO:0000154; GO:0000179; GO:0016020
GN020200	GN020200.1	Q7Z6M2	29.3	426	588	555	1.94e-36	146	FBX33_HUMAN	F-box only protein 33	Homo sapiens (Human)	positive regulation of protein ubiquitination [GO:0031398]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]		SCF ubiquitin ligase complex [GO:0019005]	GO:0016567; GO:0019005; GO:0031146; GO:0031398
GN020202	GN020202.1	Q96L03	38.6	363	352	361	3.60e-66	216	SPT17_HUMAN	Spermatogenesis-associated protein 17	Homo sapiens (Human)			cytoplasm [GO:0005737]	GO:0005737
GN020203	GN020203.1	B5G1P1	62.5	72	124	204	1.33e-21	88.2	IFT43_TAEGU	Intraflagellar transport protein 43 homolog	Taeniopygia guttata (Zebra finch) (Poephila guttata)	cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]		cilium [GO:0005929]; cytoskeleton [GO:0005856]; intraciliary transport particle A [GO:0030991]	GO:0005856; GO:0005929; GO:0030991; GO:0035721; GO:0060271
GN020207	GN020207.1	Q58DA5	29.6	277	399	345	5.45e-33	129	NTRI_BOVIN	Neurotrimin	Bos taurus (Bovine)	heterophilic cell-cell adhesion [GO:0007157]; regulation of synapse assembly [GO:0051963]		plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic active zone membrane [GO:0048787]	GO:0005886; GO:0007157; GO:0048787; GO:0051963; GO:0098839
GN020208	GN020208.1	P31938	72.5	306	359	393	2.22e-149	429	MP2K1_MOUSE	Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)	Mus musculus (Mouse)	Bergmann glial cell differentiation [GO:0060020]; cell motility [GO:0048870]; cellular senescence [GO:0090398]; cerebellar cortex formation [GO:0021697]; epithelial cell proliferation involved in lung morphogenesis [GO:0060502]; ERBB signaling pathway [GO:0038127]; ERBB2-ERBB3 signaling pathway [GO:0038133]; ERK1 and ERK2 cascade [GO:0070371]; face development [GO:0060324]; Golgi inheritance [GO:0048313]; heart development [GO:0007507]; insulin receptor signaling pathway [GO:0008286]; insulin-like growth factor receptor signaling pathway [GO:0048009]; keratinocyte differentiation [GO:0030216]; labyrinthine layer development [GO:0060711]; lung morphogenesis [GO:0060425]; MAPK cascade [GO:0000165]; melanosome transport [GO:0032402]; myelination [GO:0042552]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of homotypic cell-cell adhesion [GO:0034111]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; neuromuscular junction development [GO:0007528]; neuron differentiation [GO:0030182]; neuron projection morphogenesis [GO:0048812]; placenta blood vessel development [GO:0060674]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of autophagy [GO:0010508]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of muscle contraction [GO:0045933]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; protein phosphorylation [GO:0006468]; regulation of axon regeneration [GO:0048679]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of Golgi inheritance [GO:0090170]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of stress-activated MAPK cascade [GO:0032872]; regulation of vascular associated smooth muscle contraction [GO:0003056]; response to axon injury [GO:0048678]; response to glucocorticoid [GO:0051384]; response to oxidative stress [GO:0006979]; Schwann cell development [GO:0014044]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea formation [GO:0060440]; triglyceride homeostasis [GO:0070328]; vesicle transport along microtubule [GO:0047496]	ATP binding [GO:0005524]; MAP kinase kinase activity [GO:0004708]; MAP kinase scaffold activity [GO:0005078]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein kinase binding [GO:0019901]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; protein-containing complex binding [GO:0044877]; scaffold protein binding [GO:0097110]; small GTPase binding [GO:0031267]	axon [GO:0030424]; cell cortex [GO:0005938]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]	GO:0000165; GO:0003056; GO:0004674; GO:0004708; GO:0004712; GO:0004713; GO:0005078; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005769; GO:0005770; GO:0005783; GO:0005794; GO:0005813; GO:0005829; GO:0005874; GO:0005886; GO:0005925; GO:0005938; GO:0006468; GO:0006979; GO:0007507; GO:0007528; GO:0008285; GO:0008286; GO:0010508; GO:0010628; GO:0010629; GO:0014044; GO:0014069; GO:0016020; GO:0019901; GO:0021697; GO:0030182; GO:0030216; GO:0030335; GO:0030424; GO:0030425; GO:0030878; GO:0031267; GO:0031435; GO:0032402; GO:0032839; GO:0032872; GO:0032968; GO:0034111; GO:0036064; GO:0038127; GO:0038133; GO:0042552; GO:0043204; GO:0043410; GO:0043539; GO:0043547; GO:0044877; GO:0045597; GO:0045893; GO:0045933; GO:0046579; GO:0047496; GO:0048009; GO:0048313; GO:0048471; GO:0048538; GO:0048678; GO:0048679; GO:0048812; GO:0048870; GO:0050772; GO:0051384; GO:0060020; GO:0060324; GO:0060425; GO:0060440; GO:0060502; GO:0060674; GO:0060711; GO:0070328; GO:0070371; GO:0070372; GO:0070374; GO:0071902; GO:0090170; GO:0090398; GO:0097110; GO:0098696; GO:0098978; GO:0106310; GO:1903298; GO:2000641; GO:2001171
GN020209	GN020209.1	Q3T025	74.2	186	186	184	2.73e-94	275	RL17_BOVIN	Large ribosomal subunit protein uL22 (60S ribosomal protein L17)	Bos taurus (Bovine)	cytoplasmic translation [GO:0002181]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosolic large ribosomal subunit [GO:0022625]	GO:0002181; GO:0003735; GO:0005737; GO:0022625
GN020210	GN020210.1	A0JN69	40.0	155	431	253	8.83e-35	132	MARH3_BOVIN	E3 ubiquitin-protein ligase MARCHF3 (EC 2.3.2.27) (Membrane-associated RING finger protein 3) (Membrane-associated RING-CH protein III) (MARCH-III) (RING-type E3 ubiquitin transferase MARCHF3)	Bos taurus (Bovine)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	early endosome membrane [GO:0031901]; endosome [GO:0005768]; lysosome [GO:0005764]	GO:0004842; GO:0005764; GO:0005768; GO:0008270; GO:0016567; GO:0031901; GO:0061630
GN020231	GN020231.1	Q15485	42.2	90	124	313	1.04e-13	68.9	FCN2_HUMAN	Ficolin-2 (37 kDa elastin-binding protein) (EBP-37) (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35)	Homo sapiens (Human)	cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; opsonization [GO:0008228]; positive regulation of opsonization [GO:1903028]; proteolysis [GO:0006508]; recognition of apoptotic cell [GO:0043654]	antigen binding [GO:0003823]; calcium-dependent protein binding [GO:0048306]; carbohydrate derivative binding [GO:0097367]; lipoteichoic acid immune receptor activity [GO:0070892]; mannan binding [GO:2001065]; pattern recognition receptor activity [GO:0038187]; proteoglycan binding [GO:0043394]; signaling receptor binding [GO:0005102]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; serine-type endopeptidase complex [GO:1905370]; symbiont cell surface [GO:0106139]	GO:0001867; GO:0002752; GO:0003823; GO:0005102; GO:0005576; GO:0006508; GO:0008228; GO:0009897; GO:0009986; GO:0031012; GO:0038187; GO:0043394; GO:0043654; GO:0048306; GO:0050829; GO:0050830; GO:0070062; GO:0070892; GO:0072562; GO:0097367; GO:0106139; GO:1903028; GO:1905370; GO:2001065
GN020234	GN020234.1	Q14314	40.9	232	222	439	1.02e-46	162	FGL2_HUMAN	Fibroleukin (Fibrinogen-like protein 2) (pT49)	Homo sapiens (Human)			extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; fibrinogen complex [GO:0005577]; ficolin-1-rich granule lumen [GO:1904813]; non-collagenous component of basement membrane [GO:0140144]	GO:0005576; GO:0005577; GO:0031012; GO:0070062; GO:0140144; GO:1904813
GN020235	GN020235.1	Q14314	41.4	232	222	439	3.69e-47	164	FGL2_HUMAN	Fibroleukin (Fibrinogen-like protein 2) (pT49)	Homo sapiens (Human)			extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; fibrinogen complex [GO:0005577]; ficolin-1-rich granule lumen [GO:1904813]; non-collagenous component of basement membrane [GO:0140144]	GO:0005576; GO:0005577; GO:0031012; GO:0070062; GO:0140144; GO:1904813
GN020238	GN020238.1	Q9VCA2	29.5	559	555	548	2.15e-60	212	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN020244	GN020244.1	Q86Z23	29.4	143	298	238	8.25e-11	64.3	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN020259	GN020259.1	Q9QXM0	50.3	338	352	425	9.18e-117	347	ABHD2_MOUSE	Monoacylglycerol lipase ABHD2 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 2) (Acetylesterase) (EC 3.1.1.6) (Lung alpha/beta hydrolase 2) (MmLABH2) (Triacylglycerol lipase) (EC 3.1.1.79)	Mus musculus (Mouse)	acrosome reaction [GO:0007340]; acylglycerol catabolic process [GO:0046464]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793]; negative regulation of cell migration [GO:0030336]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; sperm capacitation [GO:0048240]; steroid hormone receptor signaling pathway [GO:0043401]	acetylesterase activity [GO:0008126]; diacylglycerol lipase activity [GO:0120516]; hormone binding [GO:0042562]; monoacylglycerol lipase activity [GO:0047372]; nuclear steroid receptor activity [GO:0003707]; triacylglycerol lipase activity [GO:0004806]	acrosomal membrane [GO:0002080]; acrosomal vesicle [GO:0001669]; plasma membrane [GO:0005886]; sperm flagellum [GO:0036126]; sperm plasma membrane [GO:0097524]	GO:0001669; GO:0002080; GO:0003707; GO:0004806; GO:0005886; GO:0007340; GO:0008126; GO:0009611; GO:0030336; GO:0032570; GO:0036126; GO:0042562; GO:0043401; GO:0046464; GO:0047372; GO:0048240; GO:0051792; GO:0051793; GO:0097524; GO:0120516
GN020260	GN020260.1	Q9P2Z0	37.2	86	184	257	2.60e-14	72.0	THA10_HUMAN	THAP domain-containing protein 10	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]		GO:0043565
GN020263	GN020263.1	P62490	88.9	216	216	216	3.36e-133	375	RB11A_CANLF	Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2)	Canis lupus familiaris (Dog) (Canis familiaris)	amyloid-beta clearance by transcytosis [GO:0150093]; astral microtubule organization [GO:0030953]; establishment of protein localization to organelle [GO:0072594]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanosome transport [GO:0032402]; mitotic metaphase chromosome alignment [GO:0007080]; mitotic spindle assembly [GO:0090307]; multivesicular body assembly [GO:0036258]; neuron projection development [GO:0031175]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mitotic cytokinetic process [GO:1903438]; protein localization to cilium [GO:0061512]; protein localization to plasma membrane [GO:0072659]; regulation of cilium assembly [GO:1902017]; regulation of endocytic recycling [GO:2001135]; regulation of protein localization to centrosome [GO:1904779]	dynein light intermediate chain binding [GO:0051959]; G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; cilium [GO:0005929]; cleavage furrow [GO:0032154]; cytoplasmic vesicle membrane [GO:0030659]; endocytic vesicle membrane [GO:0030666]; endosome membrane [GO:0010008]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; kinetochore microtubule [GO:0005828]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic recycling endosome [GO:0098837]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; spindle pole [GO:0000922]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]	GO:0000139; GO:0000922; GO:0003924; GO:0003925; GO:0005525; GO:0005771; GO:0005794; GO:0005813; GO:0005814; GO:0005828; GO:0005886; GO:0005929; GO:0006887; GO:0007080; GO:0008017; GO:0010008; GO:0010634; GO:0010971; GO:0019904; GO:0030133; GO:0030659; GO:0030666; GO:0030670; GO:0030953; GO:0031175; GO:0031489; GO:0032154; GO:0032402; GO:0032588; GO:0032991; GO:0034451; GO:0036258; GO:0045335; GO:0048471; GO:0051959; GO:0055037; GO:0055038; GO:0061512; GO:0070062; GO:0070382; GO:0072594; GO:0072659; GO:0090307; GO:0098837; GO:0098887; GO:0098978; GO:0150093; GO:1902017; GO:1903438; GO:1904779; GO:1990182; GO:2001135
GN020265	GN020265.1	Q5VSE6	45.4	304	260	412	3.51e-70	224	KCNKD_DANRE	Potassium channel, subfamily K, member 13 (K2P13.1b) (Tandem pore domain halothane-inhibited potassium channel)	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of excitatory synapse pruning [GO:1905810]; regulation of NLRP3 inflammasome complex assembly [GO:1900225]; regulation of resting membrane potential [GO:0060075]	identical protein binding [GO:0042802]; outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]; protein heterodimerization activity [GO:0046982]	plasma membrane [GO:0005886]	GO:0005886; GO:0015271; GO:0022841; GO:0042802; GO:0046982; GO:0060075; GO:1900225; GO:1905810
GN020282	GN020282.1	Q9V4X2	47.6	105	221	184	3.14e-28	108	PGSC2_DROME	Peptidoglycan-recognition protein SC2 (EC 3.5.1.28)	Drosophila melanogaster (Fruit fly)	defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0002814]; negative regulation of peptidoglycan recognition protein signaling pathway [GO:0061060]; peptidoglycan catabolic process [GO:0009253]; Toll receptor ligand protein activation cascade [GO:0160032]	N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan immune receptor activity [GO:0016019]; zinc ion binding [GO:0008270]	extracellular region [GO:0005576]	GO:0002814; GO:0005576; GO:0006955; GO:0008270; GO:0008745; GO:0009253; GO:0016019; GO:0042834; GO:0045087; GO:0050830; GO:0061060; GO:0160032
GN020283	GN020283.1	Q9EQU3	29.6	142	584	1032	1.83e-10	67.8	TLR9_MOUSE	Toll-like receptor 9 (CD antigen CD289)	Mus musculus (Mouse)	activation of innate immune response [GO:0002218]; canonical NF-kappaB signal transduction [GO:0007249]; cellular response to chloroquine [GO:1902350]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to metal ion [GO:0071248]; defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; detection of molecule of bacterial origin [GO:0032490]; immune response [GO:0006955]; innate immune response [GO:0045087]; maintenance of gastrointestinal epithelium [GO:0030277]; male gonad development [GO:0008584]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901895]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell activation [GO:0050871]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of intestinal epithelial cell development [GO:1905300]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of toll-like receptor 9 signaling pathway [GO:0034165]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; positive regulation of type II interferon production [GO:0032729]; regulation of B cell activation [GO:0050864]; regulation of B cell differentiation [GO:0045577]; regulation of dendritic cell cytokine production [GO:0002730]; regulation of inflammatory response [GO:0050727]; regulation of protein phosphorylation [GO:0001932]; response to molecule of bacterial origin [GO:0002237]; response to virus [GO:0009615]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]	interleukin-1 receptor binding [GO:0005149]; pattern recognition receptor activity [GO:0038187]; protein homodimerization activity [GO:0042803]; siRNA binding [GO:0035197]; unmethylated CpG binding [GO:0045322]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endolysosome [GO:0036019]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]	GO:0000139; GO:0001774; GO:0001819; GO:0001932; GO:0002218; GO:0002224; GO:0002237; GO:0002639; GO:0002730; GO:0002755; GO:0005149; GO:0005737; GO:0005764; GO:0005768; GO:0005783; GO:0005789; GO:0005886; GO:0006955; GO:0007249; GO:0008584; GO:0009615; GO:0010508; GO:0010628; GO:0016323; GO:0016324; GO:0030277; GO:0030890; GO:0031901; GO:0032009; GO:0032481; GO:0032490; GO:0032722; GO:0032725; GO:0032727; GO:0032728; GO:0032729; GO:0032733; GO:0032735; GO:0032741; GO:0032755; GO:0032757; GO:0032760; GO:0034162; GO:0034165; GO:0035197; GO:0036019; GO:0038187; GO:0042803; GO:0043123; GO:0043410; GO:0045087; GO:0045322; GO:0045335; GO:0045577; GO:0045944; GO:0046330; GO:0050727; GO:0050729; GO:0050829; GO:0050864; GO:0050871; GO:0051607; GO:0070373; GO:0071222; GO:0071248; GO:1900227; GO:1901895; GO:1902350; GO:1905300
GN020285	GN020285.1	A8WQH2	30.4	191	518	1288	4.24e-16	85.5	PXDN1_CAEBR	Peroxidasin homolog (EC 1.11.2.-)	Caenorhabditis briggsae	muscle organ development [GO:0007517]; regulation of axon guidance [GO:1902667]; response to oxidative stress [GO:0006979]	heme binding [GO:0020037]; peroxidase activity [GO:0004601]	basement membrane [GO:0005604]	GO:0004601; GO:0005604; GO:0006979; GO:0007517; GO:0020037; GO:1902667
GN020287	GN020287.1	Q9R0P6	86.1	144	146	179	5.50e-87	254	SC11A_MOUSE	Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) (Sid 2895)	Mus musculus (Mouse)	protein maturation [GO:0051604]; protein processing [GO:0016485]	peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; signal peptidase activity [GO:0009003]	endoplasmic reticulum membrane [GO:0005789]; signal peptidase complex [GO:0005787]	GO:0004252; GO:0005787; GO:0005789; GO:0008233; GO:0009003; GO:0016485; GO:0051604
GN020288	GN020288.1	Q8K2P6	29.3	116	120	157	9.60e-17	74.3	RFESD_MOUSE	Rieske domain-containing protein	Mus musculus (Mouse)		2 iron, 2 sulfur cluster binding [GO:0051537]		GO:0051537
GN020291	GN020291.1	Q96PH1	51.3	439	475	765	5.97e-143	431	NOX5_HUMAN	NADPH oxidase 5 (EC 1.-.-.-) (EC 1.6.3.-)	Homo sapiens (Human)	angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cytoskeleton-dependent cytokinesis [GO:0061640]; defense response [GO:0006952]; endothelial cell proliferation [GO:0001935]; positive regulation of cytokine production [GO:0001819]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; proton transmembrane transport [GO:1902600]; regulation of fusion of sperm to egg plasma membrane [GO:0043012]; superoxide anion generation [GO:0042554]	calcium ion binding [GO:0005509]; flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; NADP binding [GO:0050661]; proton channel activity [GO:0015252]; superoxide-generating NAD(P)H oxidase activity [GO:0016175]; superoxide-generating NADPH oxidase activity [GO:0106292]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]	GO:0001525; GO:0001819; GO:0001935; GO:0005509; GO:0005783; GO:0005789; GO:0005886; GO:0006915; GO:0006952; GO:0015252; GO:0016175; GO:0020037; GO:0042554; GO:0043012; GO:0043020; GO:0050660; GO:0050661; GO:0061640; GO:0106292; GO:1902600; GO:2000379
GN020292	GN020292.1	O15484	43.5	635	632	640	4.85e-176	517	CAN5_HUMAN	Calpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3)	Homo sapiens (Human)	proteolysis [GO:0006508]; signal transduction [GO:0007165]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; synapse [GO:0045202]	GO:0004198; GO:0005737; GO:0005925; GO:0006508; GO:0007165; GO:0009986; GO:0045202; GO:0070062
GN020309	GN020309.1	Q1HE26	60.3	587	573	553	1.14e-224	635	SMAD4_BOVIN	SMAD family member 4 (SMAD 4) (Mothers against decapentaplegic homolog 4) (MAD homolog 4) (Mothers against DPP homolog 4)	Bos taurus (Bovine)	anatomical structure morphogenesis [GO:0009653]; BMP signaling pathway [GO:0030509]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]; SMAD protein signal transduction [GO:0060395]; transforming growth factor beta receptor signaling pathway [GO:0007179]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; I-SMAD binding [GO:0070411]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; heteromeric SMAD protein complex [GO:0071144]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0005737; GO:0006357; GO:0007179; GO:0009653; GO:0030154; GO:0030509; GO:0060395; GO:0070411; GO:0071144
GN020310	GN020310.1	O57579	31.4	421	405	972	7.24e-63	221	AMPN_CHICK	Aminopeptidase Ey (EC 3.4.11.20) (Aminopeptidase N)	Gallus gallus (Chicken)	angiotensin maturation [GO:0002003]; peptide catabolic process [GO:0043171]	metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]	GO:0002003; GO:0005886; GO:0008270; GO:0043171; GO:0070006
GN020314	GN020314.1	Q6L6Q5	91.2	68	70	137	2.16e-43	139	LYS_OSTED	Lysozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase) (Invertebrate-type lysozyme)	Ostrea edulis (Native oyster) (European flat oyster)		lysozyme activity [GO:0003796]	extracellular region [GO:0005576]	GO:0003796; GO:0005576
GN020317	GN020317.1	Q6L6Q5	91.2	68	70	137	1.07e-43	140	LYS_OSTED	Lysozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase) (Invertebrate-type lysozyme)	Ostrea edulis (Native oyster) (European flat oyster)		lysozyme activity [GO:0003796]	extracellular region [GO:0005576]	GO:0003796; GO:0005576
GN020318	GN020318.1	Q28343	32.8	134	255	2333	5.29e-16	80.9	PGCA_CANLF	Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP)	Canis lupus familiaris (Dog) (Canis familiaris)	cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; skeletal system development [GO:0001501]	calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540]	perineuronal net [GO:0072534]; synapse [GO:0045202]	GO:0001501; GO:0005509; GO:0005540; GO:0007155; GO:0007417; GO:0045202; GO:0072534
GN020323	GN020323.1	P57436	34.5	145	338	264	1.86e-11	67.0	Y355_BUCAI	Uncharacterized metal-dependent hydrolase BU355 (EC 3.1.-.-)	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium)		DNA nuclease activity [GO:0004536]; hydrolase activity, acting on ester bonds [GO:0016788]	cytosol [GO:0005829]	GO:0004536; GO:0005829; GO:0016788
GN020366	GN020366.1	Q9CY57	65.9	82	278	249	5.09e-18	84.3	CHTOP_MOUSE	Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG)	Mus musculus (Mouse)	chromatin remodeling [GO:0006338]; in utero embryonic development [GO:0001701]; mRNA export from nucleus [GO:0006406]; positive regulation of ATP-dependent activity [GO:0032781]; positive regulation of helicase activity [GO:0051096]	methyl-CpG binding [GO:0008327]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; transcription export complex [GO:0000346]	GO:0000346; GO:0001701; GO:0005634; GO:0005730; GO:0006338; GO:0006406; GO:0008327; GO:0016607; GO:0032781; GO:0051096
GN020368	GN020368.1	A0JNC0	45.2	294	329	359	2.77e-61	202	TMOD1_BOVIN	Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)	Bos taurus (Bovine)	actin filament organization [GO:0007015]; lens fiber cell development [GO:0070307]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]	actin binding [GO:0003779]; tropomyosin binding [GO:0005523]	actin filament [GO:0005884]; COP9 signalosome [GO:0008180]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; membrane [GO:0016020]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]	GO:0003779; GO:0005523; GO:0005856; GO:0005865; GO:0005884; GO:0006936; GO:0007015; GO:0008180; GO:0016020; GO:0030016; GO:0030017; GO:0030239; GO:0030863; GO:0051694; GO:0070307
GN020369	GN020369.1	Q5ZIJ9	41.0	244	1046	954	7.90e-39	160	MIB2_CHICK	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (RING-type E3 ubiquitin transferase MIB2)	Gallus gallus (Chicken)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]	GO:0005737; GO:0008270; GO:0016567; GO:0061630
GN020372	GN020372.1	P26039	62.4	117	144	2541	3.25e-31	120	TLN1_MOUSE	Talin-1	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; cell-cell adhesion [GO:0098609]; cell-substrate junction assembly [GO:0007044]; cortical actin cytoskeleton organization [GO:0030866]; cortical microtubule organization [GO:0043622]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]	actin filament binding [GO:0051015]; integrin binding [GO:0005178]; LIM domain binding [GO:0030274]; phosphatidylinositol binding [GO:0035091]; phosphatidylserine binding [GO:0001786]; structural constituent of cytoskeleton [GO:0005200]; vinculin binding [GO:0017166]	adherens junction [GO:0005912]; cell surface [GO:0009986]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]	GO:0001726; GO:0001786; GO:0005178; GO:0005200; GO:0005737; GO:0005829; GO:0005886; GO:0005912; GO:0005925; GO:0007044; GO:0007229; GO:0009986; GO:0017166; GO:0030036; GO:0030274; GO:0030866; GO:0032587; GO:0033622; GO:0034451; GO:0035091; GO:0043622; GO:0051015; GO:0098609
GN020373	GN020373.1	Q8IV35	42.6	1036	1141	1049	1.54e-267	785	CF337_HUMAN	Cilia- and flagella-associated protein 337 (WD repeat-containing protein 49)	Homo sapiens (Human)		calcium ion binding [GO:0005509]	cilium [GO:0005929]	GO:0005509; GO:0005929
GN020374	GN020374.1	Q9N294	37.2	242	372	301	2.03e-45	160	B3GT5_PANPA	Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)	Pan paniscus (Pygmy chimpanzee) (Bonobo)	protein O-linked glycosylation [GO:0006493]	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity [GO:0008499]	endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005783; GO:0006493; GO:0008499
GN020375	GN020375.1	Q6P3Z3	51.6	62	376	569	2.67e-11	68.6	THAP4_MOUSE	Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric nitrobindin) (Nb(III)) (THAP domain-containing protein 4)	Mus musculus (Mouse)	cellular response to reactive nitrogen species [GO:1902170]; nitrate metabolic process [GO:0042126]	heme binding [GO:0020037]; identical protein binding [GO:0042802]; nitric oxide binding [GO:0070026]; peroxynitrite isomerase activity [GO:0062213]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0020037; GO:0042126; GO:0042802; GO:0062213; GO:0070026; GO:1902170
GN020385	GN020385.1	Q9P2Z0	37.2	86	129	257	5.44e-15	72.0	THA10_HUMAN	THAP domain-containing protein 10	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]		GO:0043565
GN020397	GN020397.1	Q9H8Y1	31.6	152	666	702	1.12e-10	68.6	VRTN_HUMAN	Vertnin	Homo sapiens (Human)	regulation of transcription by RNA polymerase II [GO:0006357]	sequence-specific DNA binding [GO:0043565]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0006357; GO:0043565
GN020407	GN020407.1	Q5AXT5	31.8	176	174	745	8.41e-22	94.7	PIF1_EMENI	ATP-dependent DNA helicase PIF1 (EC 5.6.2.3) (DNA 5'-3' helicase PIF1) (DNA repair and recombination helicase PIF1)	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)	DNA recombination [GO:0006310]; DNA repair [GO:0006281]; replication fork reversal [GO:0071932]; telomere maintenance [GO:0000723]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; single-stranded DNA binding [GO:0003697]	mitochondrion [GO:0005739]; nuclear replication fork [GO:0043596]	GO:0000723; GO:0003697; GO:0005524; GO:0005739; GO:0006281; GO:0006310; GO:0016887; GO:0043139; GO:0043596; GO:0071932
GN020409	GN020409.1	P0C6Y7	44.4	63	174	796	8.97e-12	65.9	PRDM9_RAT	Histone-lysine N-methyltransferase PRDM9 (PR domain zinc finger protein 9) (PR domain-containing protein 9) (Protein-lysine N-methyltransferase PRDM9) (EC 2.1.1.-) ([histone H3]-lysine36 N-trimethyltransferase PRDM9) (EC 2.1.1.359) ([histone H3]-lysine4 N-trimethyltransferase PRDM9) (EC 2.1.1.354) ([histone H3]-lysine9 N-trimethyltransferase PRDM9) (EC 2.1.1.355) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.361)	Rattus norvegicus (Rat)	double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; homologous chromosome pairing at meiosis [GO:0007129]; male gamete generation [GO:0048232]; meiotic gene conversion [GO:0006311]; negative regulation of apoptotic process [GO:0043066]; positive regulation of fertilization [GO:1905516]; positive regulation of meiosis I [GO:0060903]; positive regulation of reciprocal meiotic recombination [GO:0010845]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283]	histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 trimethyltransferase activity [GO:0140999]; histone H3K9 trimethyltransferase activity [GO:0140949]; histone H4K20 monomethyltransferase activity [GO:0140944]; histone H4K20me methyltransferase activity [GO:0140941]; protein homodimerization activity [GO:0042803]; protein-lysine N-methyltransferase activity [GO:0016279]; recombination hotspot binding [GO:0010844]; sequence-specific DNA binding [GO:0043565]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000976; GO:0005634; GO:0005654; GO:0005694; GO:0006311; GO:0007129; GO:0007283; GO:0007292; GO:0008270; GO:0010468; GO:0010844; GO:0010845; GO:0016279; GO:0042800; GO:0042803; GO:0043066; GO:0043565; GO:0045944; GO:0046975; GO:0048232; GO:0060903; GO:0140941; GO:0140944; GO:0140949; GO:0140955; GO:0140999; GO:1905516; GO:1990918
GN020411	GN020411.1	Q9NQW5	36.9	149	360	492	1.41e-19	93.2	PRDM7_HUMAN	Histone-lysine N-methyltransferase PRDM7 (EC 2.1.1.-) (PR domain zinc finger protein 7) (PR domain-containing protein 7) ([histone H3]-lysine4 N-methyltransferase PRDM7)	Homo sapiens (Human)	regulation of DNA-templated transcription [GO:0006355]	histone H3K4 methyltransferase activity [GO:0042800]	chromosome [GO:0005694]; nucleus [GO:0005634]	GO:0005634; GO:0005694; GO:0006355; GO:0042800
GN020412	GN020412.1	A0A163UT06	37.4	123	375	277	5.62e-20	92.0	SET17_CAEEL	Histone-lysine N-methyltransferase set-17 (EC 2.1.1.-) (EC 2.1.1.364) (SET domain-containing protein 17)	Caenorhabditis elegans		histone H3K4 methyltransferase activity [GO:0042800]; histone H3K4 monomethyltransferase activity [GO:0140945]	nucleus [GO:0005634]	GO:0005634; GO:0042800; GO:0140945
GN020416	GN020416.1	Q13467	40.6	106	282	585	3.95e-21	96.3	FZD5_HUMAN	Frizzled-5 (Fz-5) (hFz5) (FzE5)	Homo sapiens (Human)	anterior/posterior axis specification, embryo [GO:0008595]; canonical Wnt signaling pathway [GO:0060070]; cellular response to molecule of bacterial origin [GO:0071219]; embryonic axis specification [GO:0000578]; embryonic camera-type eye morphogenesis [GO:0048596]; eye development [GO:0001654]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of protein localization to mitochondrion [GO:1903749]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; regulation of mitophagy [GO:1901524]; Spemann organizer formation [GO:0060061]; synapse assembly [GO:0007416]	amyloid-beta binding [GO:0001540]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]	axon [GO:0030424]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0000139; GO:0000578; GO:0001540; GO:0001654; GO:0002726; GO:0005886; GO:0005923; GO:0007416; GO:0008595; GO:0009986; GO:0017147; GO:0019901; GO:0030182; GO:0030424; GO:0030425; GO:0030669; GO:0031625; GO:0031901; GO:0032729; GO:0032731; GO:0032760; GO:0035567; GO:0042813; GO:0043204; GO:0044877; GO:0045202; GO:0045944; GO:0048471; GO:0048596; GO:0060061; GO:0060070; GO:0071219; GO:1901524; GO:1903749
GN020417	GN020417.1	Q62172	52.3	285	910	648	2.64e-85	290	RBP1_MOUSE	RalA-binding protein 1 (RalBP1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1)	Mus musculus (Mouse)	doxorubicin transport [GO:1900753]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein phosphorylation [GO:0001934]; receptor-mediated endocytosis [GO:0006898]; regulation of Cdc42 protein signal transduction [GO:0032489]; small GTPase-mediated signal transduction [GO:0007264]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type xenobiotic transporter activity [GO:0008559]; ATPase-coupled transmembrane transporter activity [GO:0042626]; GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; spindle pole [GO:0000922]	GO:0000922; GO:0001934; GO:0005096; GO:0005634; GO:0005654; GO:0005739; GO:0005829; GO:0005886; GO:0006898; GO:0007264; GO:0008559; GO:0015431; GO:0016020; GO:0016604; GO:0022857; GO:0031267; GO:0032489; GO:0042626; GO:0042910; GO:0043547; GO:0055085; GO:0090141; GO:0098685; GO:1900753; GO:1990961
GN020420	GN020420.1	C4N147	39.6	134	135	132	4.93e-19	80.1	FABP1_DORPE	Sodium/calcium exchanger regulatory protein 1 (ReP1-NCXSQ) (Fatty acid-binding protein 1) (Na(+)/Ca(2+) exchanger regulatory protein 1)	Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)		lipid binding [GO:0008289]	cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0005737; GO:0008289; GO:0016020
GN020433	GN020433.1	A0A345BJN8	30.6	248	491	919	1.12e-23	108	CLZ9_COCLU	MFS-type transporter clz9 (Squalestatin S1 biosynthesis cluster protein clz9) (Zaragozic acid A biosynthesis cluster protein 9)	Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata)	export across plasma membrane [GO:0140115]	citrate transmembrane transporter activity [GO:0015137]; nucleic acid binding [GO:0003676]	plasma membrane [GO:0005886]	GO:0003676; GO:0005886; GO:0015137; GO:0140115
GN020445	GN020445.1	Q5ZJU0	22.9	471	528	507	4.66e-24	108	MOT9_CHICK	Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9)	Gallus gallus (Chicken)	carboxylic acid transmembrane transport [GO:1905039]; carnitine transmembrane transport [GO:1902603]; creatine transmembrane transport [GO:0015881]	carnitine transmembrane transporter activity [GO:0015226]; creatine transmembrane transporter activity [GO:0005308]; monocarboxylic acid transmembrane transporter activity [GO:0008028]	plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0008028; GO:0015226; GO:0015881; GO:1902603; GO:1905039
GN020447	GN020447.1	Q6PCJ1	50.7	73	233	1232	5.68e-13	71.2	DCTN1_XENLA	Dynactin subunit 1	Xenopus laevis (African clawed frog)	cytoplasmic microtubule organization [GO:0031122]; establishment of mitotic spindle orientation [GO:0000132]; nuclear migration [GO:0007097]; positive regulation of intracellular protein transport [GO:0090316]; regulation of mitotic spindle organization [GO:0060236]	microtubule binding [GO:0008017]	axon [GO:0030424]; cell cortex [GO:0005938]; cell cortex region [GO:0099738]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule plus-end [GO:0035371]; spindle pole [GO:0000922]	GO:0000132; GO:0000776; GO:0000922; GO:0005737; GO:0005813; GO:0005814; GO:0005874; GO:0005875; GO:0005938; GO:0007097; GO:0008017; GO:0030424; GO:0031122; GO:0035371; GO:0060236; GO:0090316; GO:0099738
GN020448	GN020448.1	Q86UK5	23.4	834	1323	1308	2.29e-14	82.4	LBN_HUMAN	Limbin (Ellis-van Creveld syndrome protein 2) (EVC2)	Homo sapiens (Human)	smoothened signaling pathway [GO:0007224]		ciliary membrane [GO:0060170]; cilium [GO:0005929]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]	GO:0005634; GO:0005886; GO:0005929; GO:0007224; GO:0060170; GO:0098797
GN020450	GN020450.1	Q68FT3	56.8	213	220	581	2.94e-70	227	PYRD2_RAT	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC 1.-.-.-)	Rattus norvegicus (Rat)	mitochondrion organization [GO:0007005]	oxidoreductase activity [GO:0016491]	mitochondrial matrix [GO:0005759]	GO:0005759; GO:0007005; GO:0016491
GN020451	GN020451.1	Q3MHH6	57.3	347	369	581	1.53e-130	389	PYRD2_BOVIN	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC 1.-.-.-)	Bos taurus (Bovine)	mitochondrion organization [GO:0007005]	oxidoreductase activity [GO:0016491]	mitochondrial matrix [GO:0005759]	GO:0005759; GO:0007005; GO:0016491
GN020453	GN020453.1	Q6AXC6	48.1	909	920	906	6.59e-276	793	DDX11_MOUSE	ATP-dependent DNA helicase DDX11 (EC 5.6.2.3) (DEAD/H-box protein 11) (DNA 5'-3' helicase DDX11)	Mus musculus (Mouse)	cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to hydroxyurea [GO:0072711]; DNA damage response [GO:0006974]; establishment of sister chromatid cohesion [GO:0034085]; negative regulation of protein binding [GO:0032091]; nucleolar chromatin organization [GO:1990700]; positive regulation of chromatin binding [GO:0035563]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of sister chromatid cohesion [GO:0045876]; positive regulation of transcription of nucleolar large rRNA by RNA polymerase I [GO:1901838]; replication fork processing [GO:0031297]; sister chromatid cohesion [GO:0007062]	5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on DNA [GO:0008094]; ATP-dependent activity, acting on RNA [GO:0008186]; catalytic activity, acting on a nucleic acid [GO:0140640]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA replication origin binding [GO:0003688]; double-stranded DNA binding [GO:0003690]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex unwinding activity [GO:0160225]; helicase activity [GO:0004386]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; triplex DNA binding [GO:0045142]	centrosome [GO:0005813]; chromatin [GO:0000785]; chromosome [GO:0005694]; extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	GO:0000785; GO:0000922; GO:0003677; GO:0003678; GO:0003682; GO:0003688; GO:0003690; GO:0003697; GO:0003727; GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005813; GO:0006974; GO:0007062; GO:0008094; GO:0008186; GO:0016887; GO:0030496; GO:0031297; GO:0032091; GO:0034085; GO:0035563; GO:0043139; GO:0045142; GO:0045876; GO:0051880; GO:0070062; GO:0072711; GO:0072719; GO:0140640; GO:0160225; GO:1901838; GO:1904976; GO:1990700; GO:2000781
GN020460	GN020460.1	Q6P3Z3	48.4	62	319	569	2.77e-10	64.7	THAP4_MOUSE	Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric nitrobindin) (Nb(III)) (THAP domain-containing protein 4)	Mus musculus (Mouse)	cellular response to reactive nitrogen species [GO:1902170]; nitrate metabolic process [GO:0042126]	heme binding [GO:0020037]; identical protein binding [GO:0042802]; nitric oxide binding [GO:0070026]; peroxynitrite isomerase activity [GO:0062213]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0020037; GO:0042126; GO:0042802; GO:0062213; GO:0070026; GO:1902170
GN020466	GN020466.1	Q55E58	22.7	484	1306	3184	9.83e-21	103	PATS1_DICDI	Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1)	Dictyostelium discoideum (Social amoeba)	cheating during chimeric sorocarp development [GO:0099139]; mitotic cytokinesis [GO:0000281]; phosphatidylinositol dephosphorylation [GO:0046856]	ATP binding [GO:0005524]; GTP binding [GO:0005525]; phosphatidylinositol-3-phosphate phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	actomyosin [GO:0042641]; cytosol [GO:0005829]; membrane [GO:0016020]	GO:0000281; GO:0004438; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0005829; GO:0016020; GO:0042641; GO:0046856; GO:0099139; GO:0106310
GN020468	GN020468.1	Q95JJ0	36.6	322	338	350	6.91e-59	196	SG196_MACFA	Protein O-mannose kinase (POMK) (EC 2.7.1.183) (Protein kinase-like protein SgK196) (Sugen kinase 196)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	carbohydrate phosphorylation [GO:0046835]; protein O-linked glycosylation [GO:0006493]	ATP binding [GO:0005524]; carbohydrate kinase activity [GO:0019200]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; protein kinase activity [GO:0004672]	endoplasmic reticulum membrane [GO:0005789]	GO:0004672; GO:0005524; GO:0005789; GO:0006493; GO:0016773; GO:0019200; GO:0046835
GN020470	GN020470.1	P31401	91.0	488	563	494	0.0	904	VATB_MANSE	V-type proton ATPase subunit B (V-ATPase subunit B) (Vacuolar proton pump subunit B)	Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)	ATP metabolic process [GO:0046034]; vacuolar acidification [GO:0007035]	ATP binding [GO:0005524]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	proton-transporting V-type ATPase, V1 domain [GO:0033180]	GO:0005524; GO:0007035; GO:0033180; GO:0046034; GO:0046961
GN020473	GN020473.1	P35559	60.2	628	637	1019	2.18e-280	797	IDE_RAT	Insulin-degrading enzyme (EC 3.4.24.56) (Insulin protease) (Insulinase) (Insulysin)	Rattus norvegicus (Rat)	amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta metabolic process [GO:0050435]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; bradykinin catabolic process [GO:0010815]; hormone catabolic process [GO:0042447]; insulin catabolic process [GO:1901143]; insulin metabolic process [GO:1901142]; insulin receptor recycling [GO:0038020]; negative regulation of proteolysis [GO:0045861]; peptide catabolic process [GO:0043171]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of aerobic respiration [GO:1903715]; response to oxidative stress [GO:0006979]; ubiquitin recycling [GO:0010992]	amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; beta-endorphin binding [GO:0031626]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; zinc ion binding [GO:0008270]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]	GO:0001540; GO:0004175; GO:0004222; GO:0005524; GO:0005576; GO:0005634; GO:0005737; GO:0005739; GO:0005777; GO:0005782; GO:0005829; GO:0005886; GO:0006508; GO:0006979; GO:0008233; GO:0008270; GO:0009897; GO:0009986; GO:0010815; GO:0010992; GO:0016323; GO:0016887; GO:0017046; GO:0019885; GO:0030163; GO:0031597; GO:0031626; GO:0031904; GO:0038020; GO:0042277; GO:0042447; GO:0042802; GO:0042803; GO:0043171; GO:0043559; GO:0044877; GO:0045861; GO:0050435; GO:0070062; GO:0097242; GO:0150094; GO:1901142; GO:1901143; GO:1903715
GN020474	GN020474.1	Q9JHR7	54.5	354	355	1019	1.90e-123	382	IDE_MOUSE	Insulin-degrading enzyme (EC 3.4.24.56) (Insulin protease) (Insulinase) (Insulysin)	Mus musculus (Mouse)	amyloid-beta clearance [GO:0097242]; amyloid-beta clearance by cellular catabolic process [GO:0150094]; amyloid-beta metabolic process [GO:0050435]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; bradykinin catabolic process [GO:0010815]; hormone catabolic process [GO:0042447]; insulin catabolic process [GO:1901143]; insulin metabolic process [GO:1901142]; insulin receptor recycling [GO:0038020]; negative regulation of proteolysis [GO:0045861]; peptide catabolic process [GO:0043171]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; regulation of aerobic respiration [GO:1903715]; response to oxidative stress [GO:0006979]; ubiquitin recycling [GO:0010992]	amyloid-beta binding [GO:0001540]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; beta-endorphin binding [GO:0031626]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; insulin binding [GO:0043559]; metalloendopeptidase activity [GO:0004222]; peptide binding [GO:0042277]; peptide hormone binding [GO:0017046]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; zinc ion binding [GO:0008270]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; endosome lumen [GO:0031904]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]	GO:0001540; GO:0004175; GO:0004222; GO:0005524; GO:0005576; GO:0005634; GO:0005737; GO:0005739; GO:0005777; GO:0005782; GO:0005829; GO:0005886; GO:0006508; GO:0006979; GO:0008270; GO:0009897; GO:0009986; GO:0010815; GO:0010992; GO:0016323; GO:0016887; GO:0017046; GO:0019885; GO:0030163; GO:0031597; GO:0031626; GO:0031904; GO:0038020; GO:0042277; GO:0042447; GO:0042802; GO:0042803; GO:0043171; GO:0043559; GO:0044877; GO:0045861; GO:0050435; GO:0070062; GO:0097242; GO:0150094; GO:1901142; GO:1901143; GO:1903715
GN020475	GN020475.1	Q6V7V2	39.1	445	603	548	4.22e-87	284	RTKN_RAT	Rhotekin	Rattus norvegicus (Rat)	actomyosin contractile ring assembly [GO:0000915]; mitotic cytokinesis [GO:0000281]; regulation of apoptotic process [GO:0042981]; Rho protein signal transduction [GO:0007266]; septin ring organization [GO:0031106]; signal transduction [GO:0007165]	GTPase inhibitor activity [GO:0005095]; small GTPase binding [GO:0031267]	actomyosin contractile ring [GO:0005826]	GO:0000281; GO:0000915; GO:0005095; GO:0005826; GO:0007165; GO:0007266; GO:0031106; GO:0031267; GO:0042981
GN020476	GN020476.1	Q7Z5L3	29.2	130	172	287	3.41e-09	57.8	C1QL2_HUMAN	Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; postsynaptic density assembly [GO:0097107]; regulation of synapse maturation [GO:0090128]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	cerebellar climbing fiber to Purkinje cell synapse [GO:0150053]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0032991; GO:0042802; GO:0043083; GO:0045202; GO:0090128; GO:0097107; GO:0098686; GO:0099550; GO:0099558; GO:0099645; GO:0150053
GN020478	GN020478.1	Q5EA55	50.8	128	147	137	4.95e-39	131	GOGA7_BOVIN	Golgin subfamily A member 7	Bos taurus (Bovine)	Golgi to plasma membrane protein transport [GO:0043001]; post-translational protein modification [GO:0043687]; protein targeting to membrane [GO:0006612]		Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; palmitoyltransferase complex [GO:0002178]	GO:0000139; GO:0002178; GO:0005795; GO:0006612; GO:0043001; GO:0043687
GN020481	GN020481.1	Q9D826	49.2	376	378	390	1.54e-121	359	SOX_MOUSE	Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase)	Mus musculus (Mouse)	amino acid catabolic process [GO:0009063]; L-lysine catabolic process [GO:0019477]	flavin adenine dinucleotide binding [GO:0050660]; L-pipecolate oxidase activity [GO:0050031]; sarcosine oxidase activity [GO:0008115]	peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]	GO:0005777; GO:0005782; GO:0008115; GO:0009063; GO:0019477; GO:0050031; GO:0050660
GN020482	GN020482.1	Q9GR88	87.2	436	443	435	2.69e-276	756	ERF1_POLMI	Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1)	Polyandrocarpa misakiensis (Tunicate)		translation release factor activity [GO:0003747]	cytosol [GO:0005829]	GO:0003747; GO:0005829
GN020483	GN020483.1	Q8BP74	29.6	345	371	359	2.81e-38	143	PSTK_MOUSE	L-seryl-tRNA(Sec) kinase (EC 2.7.1.164) (O-phosphoseryl-tRNA(Sec) kinase)	Mus musculus (Mouse)	selenium compound metabolic process [GO:0001887]; selenocysteine incorporation [GO:0001514]	kinase activity [GO:0016301]; L-seryl-tRNA(Sec) kinase activity [GO:0043915]; seryl-selenocysteinyl-tRNA kinase activity [GO:0098620]; tRNA binding [GO:0000049]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0000049; GO:0001514; GO:0001887; GO:0005739; GO:0005829; GO:0016301; GO:0043915; GO:0098620
GN020489	GN020489.1	Q9BTE3	54.9	142	144	642	1.16e-47	165	MCMBP_HUMAN	Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein)	Homo sapiens (Human)	DNA-templated DNA replication [GO:0006261]; sister chromatid cohesion [GO:0007062]	chromatin binding [GO:0003682]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003682; GO:0005634; GO:0005654; GO:0006261; GO:0007062
GN020490	GN020490.1	Q7ZYP6	47.6	462	473	626	2.56e-136	409	MCMBP_XENLA	Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein)	Xenopus laevis (African clawed frog)	DNA-templated DNA replication [GO:0006261]; sister chromatid cohesion [GO:0007062]	chromatin binding [GO:0003682]	nucleus [GO:0005634]	GO:0003682; GO:0005634; GO:0006261; GO:0007062
GN020498	GN020498.1	Q4R910	34.9	341	524	345	1.40e-48	174	UBAC2_MACFA	Ubiquitin-associated domain-containing protein 2 (UBA domain-containing protein 2) (Phosphoglycerate dehydrogenase-like protein 1)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	negative regulation of canonical Wnt signaling pathway [GO:0090090]	serine-type endopeptidase activity [GO:0004252]	endoplasmic reticulum membrane [GO:0005789]	GO:0004252; GO:0005789; GO:0090090
GN020499	GN020499.1	Q28811	65.4	480	519	532	5.13e-238	666	PHR_POTTR	Deoxyribodipyrimidine photo-lyase (EC 4.1.99.3) (DNA photolyase) (Photoreactivating enzyme)	Potorous tridactylus (Potoroo)	photoreactive repair [GO:0000719]; UV protection [GO:0009650]	deoxyribodipyrimidine photo-lyase activity [GO:0003904]		GO:0000719; GO:0003904; GO:0009650
GN020501	GN020501.1	A9XE49	33.7	101	165	200	5.16e-09	56.2	IL17L_MAGGI	Interleukin 17-like protein (CgIL-17)	Magallana gigas (Pacific oyster) (Crassostrea gigas)		cytokine activity [GO:0005125]	extracellular region [GO:0005576]	GO:0005125; GO:0005576
GN020502	GN020502.1	P56407	78.0	59	317	147	2.08e-21	91.7	HM09_CAEEL	Homeobox protein ceh-9	Caenorhabditis elegans	cell differentiation [GO:0030154]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0030154; GO:0030182
GN020504	GN020504.1	P45954	65.7	379	484	432	3.21e-181	517	ACDSB_HUMAN	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.1) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase) (EC 1.3.8.5)	Homo sapiens (Human)	fatty acid metabolic process [GO:0006631]; L-isoleucine catabolic process [GO:0006550]	flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; medium-chain fatty acyl-CoA dehydrogenase activity [GO:0070991]; short-chain 2-methyl fatty acyl-CoA dehydrogenase activity [GO:0003853]; short-chain fatty acyl-CoA dehydrogenase activity [GO:0016937]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003853; GO:0005739; GO:0005759; GO:0006550; GO:0006631; GO:0016937; GO:0042802; GO:0050660; GO:0070991
GN020505	GN020505.1	Q9D172	63.3	199	201	266	3.53e-84	253	GAL3A_MOUSE	Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial	Mus musculus (Mouse)			mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005739; GO:0005759
GN020506	GN020506.1	A6QPC8	34.3	324	348	379	7.10e-45	160	EID3_BOVIN	EP300-interacting inhibitor of differentiation 3 (EID-3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B)	Bos taurus (Bovine)	DNA repair [GO:0006281]		chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; Smc5-Smc6 complex [GO:0030915]	GO:0000781; GO:0005634; GO:0005737; GO:0006281; GO:0030915
GN020507	GN020507.1	Q8R0X2	47.9	240	276	377	3.29e-76	239	CACL1_MOUSE	CDK2-associated and cullin domain-containing protein 1	Mus musculus (Mouse)	G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein kinase activity [GO:0045860]; ubiquitin-dependent protein catabolic process [GO:0006511]	protein kinase binding [GO:0019901]; ubiquitin protein ligase binding [GO:0031625]		GO:0000082; GO:0006511; GO:0008284; GO:0019901; GO:0031625; GO:0045860
GN020510	GN020510.1	A1A4R8	57.1	245	525	597	3.89e-94	301	CDC23_BOVIN	Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8)	Bos taurus (Bovine)	anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein branched polyubiquitination [GO:0141198]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]	enzyme-substrate adaptor activity [GO:0140767]	anaphase-promoting complex [GO:0005680]	GO:0005680; GO:0016567; GO:0031145; GO:0045842; GO:0051301; GO:0070936; GO:0070979; GO:0140767; GO:0141198
GN020512	GN020512.1	Q86Z23	28.5	130	182	238	1.62e-09	58.5	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN020517	GN020517.1	Q9BYX4	29.4	735	1077	1025	2.07e-64	240	IFIH1_HUMAN	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to virus [GO:0098586]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; negative regulation of viral genome replication [GO:0045071]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of tumor necrosis factor production [GO:0032760]; protein complex oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; regulation of type III interferon production [GO:0034344]; response to virus [GO:0009615]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; protein domain specific binding [GO:0019904]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0002753; GO:0003677; GO:0003723; GO:0003724; GO:0003725; GO:0003727; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0008270; GO:0009597; GO:0009615; GO:0016887; GO:0016925; GO:0019904; GO:0032727; GO:0032728; GO:0032755; GO:0032760; GO:0034344; GO:0038187; GO:0039530; GO:0042802; GO:0043021; GO:0045071; GO:0045087; GO:0051259; GO:0051607; GO:0060760; GO:0071360; GO:0098586; GO:0140374
GN020518	GN020518.1	Q6Q899	29.2	942	926	926	1.13e-78	278	RIGI_MOUSE	Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mRNA transcription [GO:0009299]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; ruffle membrane [GO:0032587]	GO:0002230; GO:0002735; GO:0002753; GO:0003690; GO:0003724; GO:0003725; GO:0003727; GO:0005524; GO:0005525; GO:0005737; GO:0005829; GO:0005886; GO:0005923; GO:0008270; GO:0009299; GO:0009597; GO:0009615; GO:0010467; GO:0010628; GO:0015629; GO:0016887; GO:0030334; GO:0031625; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0032760; GO:0038187; GO:0039529; GO:0042802; GO:0043330; GO:0045087; GO:0045944; GO:0051607; GO:0060760; GO:0071360; GO:0140374; GO:1990904
GN020519	GN020519.1	Q9CZJ2	33.4	287	321	685	1.14e-29	122	HS12B_MOUSE	Heat shock 70 kDa protein 12B	Mus musculus (Mouse)	angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]			GO:0001525; GO:0043542
GN020520	GN020520.1	Q8K0U4	30.7	261	262	675	7.39e-29	118	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN020521	GN020521.1	Q8K0U4	31.6	294	329	675	5.21e-28	117	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN020522	GN020522.1	Q8K0U4	30.4	385	382	675	1.19e-40	155	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN020523	GN020523.1	Q8K0U4	28.7	746	694	675	7.25e-71	246	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN020524	GN020524.1	Q28G26	67.2	381	415	492	7.27e-189	536	P4K2B_XENTR	Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	endosome organization [GO:0007032]; Golgi organization [GO:0007030]; phosphatidylinositol phosphate biosynthetic process [GO:0046854]	1-phosphatidylinositol 4-kinase activity [GO:0004430]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0004430; GO:0005768; GO:0005789; GO:0005802; GO:0005829; GO:0005886; GO:0007030; GO:0007032; GO:0031901; GO:0046854
GN020525	GN020525.1	Q8CGF7	52.4	694	1742	1100	7.89e-187	593	TCRG1_MOUSE	Transcription elongation regulator 1 (Formin-binding protein 28) (FBP 28) (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) (p144)	Mus musculus (Mouse)	DNA-templated transcription [GO:0006351]; mRNA processing [GO:0006397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA splicing [GO:0008380]	DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; proline-rich region binding [GO:0070064]; RNA polymerase binding [GO:0070063]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0003700; GO:0003712; GO:0003714; GO:0005634; GO:0005654; GO:0006351; GO:0006397; GO:0008380; GO:0042802; GO:0044390; GO:0045944; GO:0061629; GO:0070063; GO:0070064
GN020530	GN020530.1	Q503M4	24.9	437	445	477	6.34e-31	127	MT12B_DANRE	Monocarboxylate transporter 12-B (MCT 12-B) (Solute carrier family 16 member 12-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; transmembrane transporter activity [GO:0022857]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0022857; GO:0046449
GN020532	GN020532.1	O62653	51.2	285	295	1813	6.86e-86	284	SUIS_SUNMU	Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]	Suncus murinus (Asian house shrew) (Musk shrew)	carbohydrate metabolic process [GO:0005975]	alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]; oligo-1,6-glucosidase activity [GO:0004574]; sucrose alpha-glucosidase activity [GO:0004575]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]	GO:0004558; GO:0004574; GO:0004575; GO:0005737; GO:0005975; GO:0012505; GO:0030246; GO:0031526
GN020534	GN020534.1	P07768	37.2	223	293	1827	4.18e-41	155	SUIS_RABIT	Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]	Oryctolagus cuniculus (Rabbit)	carbohydrate metabolic process [GO:0005975]	alpha-1,4-glucosidase activity [GO:0004558]; carbohydrate binding [GO:0030246]; oligo-1,6-glucosidase activity [GO:0004574]; sucrose alpha-glucosidase activity [GO:0004575]	brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]	GO:0004558; GO:0004574; GO:0004575; GO:0005737; GO:0005975; GO:0012505; GO:0030246; GO:0031526
GN020535	GN020535.1	O35548	39.1	389	573	607	6.13e-73	247	MMP16_RAT	Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)	Rattus norvegicus (Rat)	bone development [GO:0060348]; chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; ossification [GO:0001503]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to odorant [GO:1990834]; skeletal system development [GO:0001501]	metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	extracellular matrix [GO:0031012]; plasma membrane [GO:0005886]	GO:0001501; GO:0001503; GO:0001958; GO:0004222; GO:0005886; GO:0006508; GO:0008270; GO:0016485; GO:0030198; GO:0030574; GO:0031012; GO:0035988; GO:0048701; GO:0060348; GO:0070006; GO:0097094; GO:1990834
GN020537	GN020537.1	Q0VD51	38.9	311	492	380	3.52e-62	210	RNF13_BOVIN	E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13)	Bos taurus (Bovine)	positive regulation of JNK cascade [GO:0046330]; protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511]	JUN kinase binding [GO:0008432]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nuclear inner membrane [GO:0005637]	GO:0004842; GO:0005637; GO:0005765; GO:0005783; GO:0005789; GO:0006511; GO:0008432; GO:0031902; GO:0046330; GO:0051865; GO:0061630
GN020538	GN020538.1	Q3SZ65	63.7	325	357	407	1.08e-152	438	IF4A2_BOVIN	Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)	Bos taurus (Bovine)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]		GO:0003676; GO:0003724; GO:0005524; GO:0016887
GN020539	GN020539.1	Q5UBV8	27.2	162	260	252	6.38e-09	58.5	TNF15_MOUSE	Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor)	Mus musculus (Mouse)	cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]	cytokine activity [GO:0005125]; tumor necrosis factor receptor binding [GO:0005164]	plasma membrane [GO:0005886]	GO:0005125; GO:0005164; GO:0005886; GO:0006955; GO:0007166; GO:0043123; GO:2001238
GN020540	GN020540.1	Q8BH74	54.5	167	168	926	2.36e-49	173	NU107_MOUSE	Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107)	Mus musculus (Mouse)	female gonad development [GO:0008585]; mRNA export from nucleus [GO:0006406]; nephron development [GO:0072006]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606]	structural constituent of nuclear pore [GO:0017056]	kinetochore [GO:0000776]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]	GO:0000776; GO:0000973; GO:0005635; GO:0005643; GO:0006406; GO:0006606; GO:0006913; GO:0008585; GO:0017056; GO:0031080; GO:0031965; GO:0034399; GO:0051292; GO:0072006
GN020547	GN020547.1	Q90XD2	68.2	239	267	340	1.33e-123	358	SPEB_CHICK	Agmatinase, mitochondrial (EC 3.5.3.11) (Agmatine ureohydrolase) (AUH)	Gallus gallus (Chicken)		agmatinase activity [GO:0008783]; guanidinobutyrase activity [GO:0047971]; metal ion binding [GO:0046872]	mitochondrion [GO:0005739]	GO:0005739; GO:0008783; GO:0046872; GO:0047971
GN020548	GN020548.1	A6H694	46.2	266	633	638	7.28e-28	122	LRC63_MOUSE	Leucine-rich repeat-containing protein 63	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]			GO:0035556
GN020552	GN020552.1	Q6NUB2	71.7	230	217	228	2.82e-86	257	CW15A_XENLA	Protein CWC15 homolog A	Xenopus laevis (African clawed frog)	mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000398; GO:0003723; GO:0005634; GO:0045292; GO:0071007; GO:0071013
GN020553	GN020553.1	Q9CQ66	61.5	78	132	144	2.57e-26	99.0	DYT2B_MOUSE	Dynein light chain Tctex-type protein 2B (Tctex1 domain-containing protein 2)	Mus musculus (Mouse)	cilium assembly [GO:0060271]; intraciliary retrograde transport [GO:0035721]; microtubule-based movement [GO:0007018]; regulation of cilium assembly [GO:1902017]; regulation of intraciliary retrograde transport [GO:1905799]	dynein intermediate chain binding [GO:0045505]	axoneme [GO:0005930]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; dynein axonemal particle [GO:0120293]; interphase microtubule organizing center [GO:0031021]; spindle pole [GO:0000922]	GO:0000922; GO:0005737; GO:0005813; GO:0005868; GO:0005930; GO:0007018; GO:0031021; GO:0035721; GO:0045505; GO:0060271; GO:0097546; GO:0120293; GO:1902017; GO:1905799
GN020554	GN020554.1	P07290	53.3	120	356	156	2.93e-35	129	MLE_MIZYE	Myosin, essential light chain, adductor muscle (Sulfhydryl light chain) (SHLC)	Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis)		calcium ion binding [GO:0005509]	muscle myosin complex [GO:0005859]	GO:0005509; GO:0005859
GN020555	GN020555.1	Q8WVM7	53.7	1109	1230	1258	0.0	1118	STAG1_HUMAN	Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1)	Homo sapiens (Human)	establishment of mitotic sister chromatid cohesion [GO:0034087]; mitotic spindle assembly [GO:0090307]	chromatin binding [GO:0003682]	chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000775; GO:0000785; GO:0003682; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0008278; GO:0016363; GO:0016604; GO:0034087; GO:0090307; GO:0097431
GN020556	GN020556.1	Q6NUB2	71.7	230	217	228	2.82e-86	257	CW15A_XENLA	Protein CWC15 homolog A	Xenopus laevis (African clawed frog)	mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]	GO:0000398; GO:0003723; GO:0005634; GO:0045292; GO:0071007; GO:0071013
GN020557	GN020557.1	Q6NY77	57.5	87	153	324	1.33e-29	112	HOGA1_DANRE	4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC 4.1.3.16) (Dihydrodipicolinate synthase-like) (DHDPS-like protein) (Probable 2-keto-4-hydroxyglutarate aldolase) (Probable KHG-aldolase)	Danio rerio (Zebrafish) (Brachydanio rerio)	glyoxylate catabolic process [GO:0009436]	(4S)-4-hydroxy-2-oxoglutarate aldolase activity [GO:0106009]; (R,S)-4-hydroxy-2-oxoglutarate aldolase activity [GO:0008700]	mitochondrion [GO:0005739]	GO:0005739; GO:0008700; GO:0009436; GO:0106009
GN020567	GN020567.1	Q5BKM3	66.4	220	216	220	1.26e-87	260	CHMP3_XENTR	Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Vacuolar protein-sorting-associated protein 24)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	late endosome to vacuole transport [GO:0045324]		cytosol [GO:0005829]; ESCRT III complex [GO:0000815]; late endosome membrane [GO:0031902]	GO:0000815; GO:0005829; GO:0031902; GO:0045324
GN020568	GN020568.1	Q15825	30.4	451	451	494	1.35e-55	195	ACHA6_HUMAN	Neuronal acetylcholine receptor subunit alpha-6	Homo sapiens (Human)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; chemical synaptic transmission [GO:0007268]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to acetylcholine [GO:1905144]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]	acetylcholine-gated channel complex [GO:0005892]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007268; GO:0007271; GO:0007274; GO:0014059; GO:0015464; GO:0022848; GO:0030594; GO:0034220; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0099171; GO:1905144
GN020569	GN020569.1	Q3T0I5	48.5	101	100	152	2.25e-25	95.5	FIS1_BOVIN	Mitochondrial fission 1 protein (Fis1 homolog)	Bos taurus (Bovine)	mitochondrial fission [GO:0000266]	lipid binding [GO:0008289]; molecular adaptor activity [GO:0060090]	mitochondrial outer membrane [GO:0005741]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]	GO:0000266; GO:0005741; GO:0005777; GO:0005778; GO:0008289; GO:0060090
GN020570	GN020570.1	Q9WU60	37.9	161	278	1428	6.04e-19	90.1	ATRN_MOUSE	Attractin (Protein mahogany)	Mus musculus (Mouse)	cerebellum development [GO:0021549]; myelination [GO:0042552]; pigmentation [GO:0043473]; regulation of multicellular organism growth [GO:0040014]; response to oxidative stress [GO:0006979]	chromatin binding [GO:0003682]; signaling receptor activity [GO:0038023]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0003682; GO:0005576; GO:0005737; GO:0005886; GO:0006979; GO:0021549; GO:0038023; GO:0040014; GO:0042552; GO:0043473
GN020572	GN020572.1	D6REC4	37.1	663	684	646	1.62e-114	361	CFA99_HUMAN	Cilia- and flagella-associated protein 99	Homo sapiens (Human)			motile cilium [GO:0031514]	GO:0031514
GN020575	GN020575.1	Q5ZJI0	63.4	273	287	371	1.20e-129	375	TPST2_CHICK	Protein-tyrosine sulfotransferase 2 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 2) (TPST-2)	Gallus gallus (Chicken)	peptidyl-tyrosine sulfation [GO:0006478]	protein-tyrosine sulfotransferase activity [GO:0008476]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005794; GO:0006478; GO:0008476
GN020578	GN020578.1	Q80W32	40.4	366	385	419	2.18e-83	263	DRC9_MOUSE	Dynein regulatory complex protein 9 (IQ domain-containing protein G)	Mus musculus (Mouse)	cilium organization [GO:0044782]; sperm axoneme assembly [GO:0007288]; spermatid development [GO:0007286]	calmodulin binding [GO:0005516]; Hsp70 protein binding [GO:0030544]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; manchette [GO:0002177]; motile cilium [GO:0031514]; sperm flagellum [GO:0036126]	GO:0002177; GO:0005516; GO:0005737; GO:0005829; GO:0007286; GO:0007288; GO:0015629; GO:0030544; GO:0031514; GO:0036126; GO:0044782
GN020579	GN020579.1	Q9H5P4	39.6	285	1127	1033	5.05e-51	199	PDZD7_HUMAN	PDZ domain-containing protein 7	Homo sapiens (Human)	auditory receptor cell development [GO:0060117]; auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of protein localization [GO:0045184]; inner ear receptor cell differentiation [GO:0060113]; sensory perception of sound [GO:0007605]	identical protein binding [GO:0042802]	cilium [GO:0005929]; extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; USH2 complex [GO:1990696]	GO:0002141; GO:0002142; GO:0005576; GO:0005634; GO:0005886; GO:0005929; GO:0007605; GO:0032420; GO:0032426; GO:0042802; GO:0045184; GO:0050910; GO:0060088; GO:0060113; GO:0060117; GO:1990696
GN020580	GN020580.1	P28361	75.2	129	305	249	1.07e-50	171	MSX1_CHICK	Homeobox protein MSX-1 (Homeobox protein Hox-7) (CHOX-7) (Msh homeobox 1-like protein)	Gallus gallus (Chicken)	BMP signaling pathway [GO:0030509]; embryonic morphogenesis [GO:0048598]; ossification [GO:0001503]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0001503; GO:0005634; GO:0005654; GO:0006357; GO:0030509; GO:0048598
GN020584	GN020584.1	P0CL94	41.8	98	157	238	2.38e-18	81.6	APTH1_CRYD1	Acyl-protein thioesterase 1 (EC 3.1.2.-) (Palmitoyl-protein hydrolase) (EC 3.1.2.22)	Cryptococcus deneoformans (strain JEC21 / ATCC MYA-565) (Cryptococcus neoformans var. neoformans serotype D)		palmitoyl-(protein) hydrolase activity [GO:0008474]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0008474
GN020585	GN020585.1	Q8K0U4	31.8	657	612	675	2.65e-89	293	HS12A_MOUSE	Heat shock 70 kDa protein 12A	Mus musculus (Mouse)	import into nucleus [GO:0051170]; inflammatory response [GO:0006954]; liver development [GO:0001889]; macrophage activation [GO:0042116]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0001889; GO:0005634; GO:0005737; GO:0006954; GO:0042116; GO:0051170
GN020586	GN020586.1	Q812E0	58.8	503	647	521	3.49e-184	534	CPEB2_MOUSE	Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (mCPEB-2)	Mus musculus (Mouse)	cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of cytoplasmic translational elongation [GO:1900248]; negative regulation of translational elongation [GO:0045900]; regulation of translation at synapse, modulating synaptic transmission [GO:0099547]	GTPase inhibitor activity [GO:0005095]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; poly-pyrimidine tract binding [GO:0008187]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; nucleus [GO:0005634]; ribosome [GO:0005840]; synapse [GO:0045202]	GO:0000900; GO:0003730; GO:0005095; GO:0005634; GO:0005737; GO:0005840; GO:0008135; GO:0008187; GO:0032869; GO:0035925; GO:0043005; GO:0043022; GO:0043023; GO:0043024; GO:0045202; GO:0045900; GO:0071456; GO:0098978; GO:0099547; GO:1900248; GO:2000766
GN020587	GN020587.1	Q8VIJ5	41.9	893	858	916	1.36e-230	675	OGA_RAT	Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Bifunctional protein NCOAT) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase)	Rattus norvegicus (Rat)	dATP metabolic process [GO:0046060]; glycoprotein metabolic process [GO:0009100]; N-acetylglucosamine metabolic process [GO:0006044]; negative regulation of cardiac muscle adaptation [GO:0010616]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cell killing [GO:0031343]; positive regulation of D-glucose import across plasma membrane [GO:0046326]; positive regulation of DNA metabolic process [GO:0051054]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of insulin secretion [GO:0032024]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of protein-containing complex disassembly [GO:0043243]; positive regulation of proteolysis [GO:0045862]; protein deglycosylation [GO:0006517]; protein targeting to membrane [GO:0006612]; response to steroid hormone [GO:0048545]	[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity [GO:0102571]; beta-N-acetylglucosaminidase activity [GO:0016231]; hexosaminidase activity [GO:0015929]; histone acetyltransferase activity [GO:0004402]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004402; GO:0005634; GO:0005737; GO:0005829; GO:0006044; GO:0006517; GO:0006612; GO:0009100; GO:0010524; GO:0010616; GO:0015929; GO:0016231; GO:0031343; GO:0032024; GO:0042802; GO:0043065; GO:0043243; GO:0045862; GO:0046060; GO:0046326; GO:0048545; GO:0051054; GO:0051901; GO:0051928; GO:0060124; GO:0102571
GN020588	GN020588.1	Q6P2X9	25.3	506	526	473	4.35e-38	149	MOT12_XENTR	Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0046449
GN020590	GN020590.1	Q6AZB8	28.8	278	375	349	1.74e-28	117	HARB1_DANRE	Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease)	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005634; GO:0005737
GN020595	GN020595.1	Q8BM75	42.6	423	954	1188	8.58e-92	320	ARI5B_MOUSE	AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (Developmentally and sexually retarded with transient immune abnormalities protein) (Desrt) (MRF1-like) (Modulator recognition factor protein 2) (MRF-2)	Mus musculus (Mouse)	adipose tissue development [GO:0060612]; adrenal gland development [GO:0030325]; cell development [GO:0048468]; cellular response to leukemia inhibitory factor [GO:1990830]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; female gonad development [GO:0008585]; fibroblast migration [GO:0010761]; kidney development [GO:0001822]; male gonad development [GO:0008584]; multicellular organism growth [GO:0035264]; muscle organ morphogenesis [GO:0048644]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; transcription initiation-coupled chromatin remodeling [GO:0045815]	DNA binding [GO:0003677]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]	catalytic complex [GO:1902494]; nucleus [GO:0005634]	GO:0000122; GO:0000976; GO:0001822; GO:0003677; GO:0003713; GO:0005634; GO:0006357; GO:0008584; GO:0008585; GO:0009791; GO:0010761; GO:0030325; GO:0035264; GO:0045444; GO:0045815; GO:0048008; GO:0048468; GO:0048644; GO:0048705; GO:0060021; GO:0060325; GO:0060612; GO:0060613; GO:1902494; GO:1990830
GN020596	GN020596.1	P56721	69.6	494	539	575	6.37e-233	656	COLL_DROME	Transcription factor collier (Transcription factor knot)	Drosophila melanogaster (Fruit fly)	anterior head segmentation [GO:0035288]; blastoderm segmentation [GO:0007350]; dendrite morphogenesis [GO:0048813]; embryonic development via the syncytial blastoderm [GO:0001700]; head segmentation [GO:0035287]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; muscle cell fate specification [GO:0042694]; positive regulation of transcription by RNA polymerase II [GO:0045944]; posterior head segmentation [GO:0035289]; regulation of dendrite morphogenesis [GO:0048814]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of lamellocyte differentiation [GO:0035203]; regulation of transcription by RNA polymerase II [GO:0006357]; response to symbiont [GO:0009608]; segment polarity determination [GO:0007367]; specification of segmental identity, intercalary segment [GO:0035291]; ventral cord development [GO:0007419]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001700; GO:0005634; GO:0006355; GO:0006357; GO:0007350; GO:0007367; GO:0007419; GO:0007474; GO:0007476; GO:0007526; GO:0009608; GO:0010468; GO:0035203; GO:0035287; GO:0035288; GO:0035289; GO:0035291; GO:0042694; GO:0045087; GO:0045944; GO:0048813; GO:0048814
GN020599	GN020599.1	A3KPQ7	28.8	1169	1090	1378	1.91e-103	358	CEIP2_DANRE	Cell surface hyaluronidase (EC 3.2.1.35) (Cell migration-inducing hyaluronidase 2) (Protein frozen ventricle) (Protein wickham) (Transmembrane protein 2)	Danio rerio (Zebrafish) (Brachydanio rerio)	atrioventricular valve formation [GO:0003190]; cardiac muscle tissue morphogenesis [GO:0055008]; cell migration involved in heart formation [GO:0060974]; cell migration to the midline involved in heart development [GO:0003318]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion development [GO:0003197]; heart looping [GO:0001947]; hyaluronan catabolic process [GO:0030214]; muscle attachment [GO:0016203]; muscle tissue morphogenesis [GO:0060415]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; regulation of sprouting angiogenesis [GO:1903670]; regulation of Wnt signaling pathway [GO:0030111]	calcium ion binding [GO:0005509]; hyalurononglucosaminidase activity [GO:0004415]	plasma membrane [GO:0005886]	GO:0001947; GO:0003143; GO:0003190; GO:0003197; GO:0003318; GO:0004415; GO:0005509; GO:0005886; GO:0016203; GO:0030111; GO:0030214; GO:0055008; GO:0060415; GO:0060974; GO:1900748; GO:1901203; GO:1903670
GN020601	GN020601.1	O35817	38.8	85	148	502	1.46e-16	78.6	AKA14_RAT	A-kinase anchor protein 14 (AKAP-14) (TAKAP-1.2) (Testis-specific A-kinase-anchoring protein TAKAP-80)	Rattus norvegicus (Rat)	spermatogenesis [GO:0007283]	protein kinase A binding [GO:0051018]; protein kinase A regulatory subunit binding [GO:0034237]	axoneme [GO:0005930]; cAMP-dependent protein kinase complex [GO:0005952]; sperm fibrous sheath [GO:0035686]	GO:0005930; GO:0005952; GO:0007283; GO:0034237; GO:0035686; GO:0051018
GN020602	GN020602.1	A0A1B0GU71	64.7	68	262	98	1.69e-24	97.1	C97D2_HUMAN	Uncharacterized protein CFAP97D2 (CFAP97 domain-containing protein 2)	Homo sapiens (Human)				
GN020605	GN020605.1	Q9ES28	41.7	729	852	862	4.69e-156	481	ARHG7_MOUSE	Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) (p85SPR)	Mus musculus (Mouse)	astrocyte cell migration [GO:0043615]; Golgi organization [GO:0007030]; hematopoietic progenitor cell differentiation [GO:0002244]; lamellipodium assembly [GO:0030032]; negative regulation of microtubule nucleation [GO:1905833]; positive regulation of apoptotic process [GO:0043065]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of GTPase activity [GO:0043547]; postsynaptic actin cytoskeleton organization [GO:0098974]; presynaptic actin cytoskeleton organization [GO:0099140]; Rho protein signal transduction [GO:0007266]; small GTPase-mediated signal transduction [GO:0007264]	ATP-dependent protein binding [GO:0043008]; gamma-tubulin binding [GO:0043015]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]	cell cortex [GO:0005938]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; mitotic spindle pole [GO:0097431]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; storage vacuole [GO:0000322]	GO:0000322; GO:0001726; GO:0002244; GO:0005085; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0005925; GO:0005938; GO:0007030; GO:0007264; GO:0007266; GO:0019901; GO:0030027; GO:0030032; GO:0030426; GO:0032991; GO:0043005; GO:0043008; GO:0043015; GO:0043025; GO:0043065; GO:0043547; GO:0043615; GO:0060124; GO:0097431; GO:0098794; GO:0098974; GO:0098982; GO:0099140; GO:1905833
GN020606	GN020606.1	Q86Z23	36.6	142	289	238	2.59e-10	62.8	C1QL4_HUMAN	Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11)	Homo sapiens (Human)	maintenance of synapse structure [GO:0099558]; trans-synaptic signaling, modulating synaptic transmission [GO:0099550]	identical protein binding [GO:0042802]	synapse [GO:0045202]; synaptic cleft [GO:0043083]	GO:0042802; GO:0043083; GO:0045202; GO:0099550; GO:0099558
GN020607	GN020607.1	P91454	59.1	110	133	112	4.85e-40	132	TIM14_CAEEL	Mitochondrial import inner membrane translocase subunit TIM14 (DnaJ homolog subfamily C member 21)	Caenorhabditis elegans	protein import into mitochondrial matrix [GO:0030150]	ATPase activator activity [GO:0001671]	mitochondrion [GO:0005739]; PAM complex, Tim23 associated import motor [GO:0001405]	GO:0001405; GO:0001671; GO:0005739; GO:0030150
GN020610	GN020610.1	Q5ZK28	34.1	167	196	461	1.17e-16	80.5	DPOD3_CHICK	DNA polymerase delta subunit 3 (DNA polymerase delta subunit p66)	Gallus gallus (Chicken)	DNA biosynthetic process [GO:0071897]; DNA replication [GO:0006260]		cytoplasm [GO:0005737]; delta DNA polymerase complex [GO:0043625]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0006260; GO:0043625; GO:0071897
GN020611	GN020611.1	Q3T0H0	47.7	310	296	332	2.97e-101	302	LCMT1_BOVIN	Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1)	Bos taurus (Bovine)	regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]	protein C-terminal leucine carboxyl O-methyltransferase activity [GO:0018423]	cytosol [GO:0005829]	GO:0005829; GO:0018423; GO:0090266
GN020613	GN020613.1	B0BNE5	70.7	256	266	282	1.01e-144	409	ESTD_RAT	S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D)	Rattus norvegicus (Rat)	formaldehyde catabolic process [GO:0046294]	hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; S-formylglutathione hydrolase activity [GO:0018738]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]	GO:0005829; GO:0016788; GO:0018738; GO:0031410; GO:0042802; GO:0046294
GN020614	GN020614.1	Q96LI9	42.7	267	437	332	4.81e-66	217	CX058_HUMAN	Uncharacterized protein CXorf58	Homo sapiens (Human)				
GN020616	GN020616.1	Q8C9S4	41.2	660	1177	917	1.38e-111	374	CC186_MOUSE	Coiled-coil domain-containing protein 186 (Oocyte-testis gene 1 protein)	Mus musculus (Mouse)	glucose homeostasis [GO:0042593]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; response to bacterium [GO:0009617]; vesicle cytoskeletal trafficking [GO:0099518]	small GTPase binding [GO:0031267]	Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802]	GO:0005794; GO:0005802; GO:0009617; GO:0031267; GO:0035773; GO:0042593; GO:0099518
GN020622	GN020622.1	C3Y431	61.6	125	302	298	1.69e-44	156	DDRGK_BRAFL	DDRGK domain-containing protein 1	Branchiostoma floridae (Florida lancelet) (Amphioxus)	cartilage development [GO:0051216]; protein K69-linked ufmylation [GO:1990592]	ubiquitin-like protein ligase binding [GO:0044389]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0044389; GO:0051216; GO:1990592
GN020623	GN020623.1	Q8R3C1	54.1	573	588	574	1.58e-206	591	CB042_MOUSE	Uncharacterized protein C2orf42 homolog	Mus musculus (Mouse)			nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654
GN020624	GN020624.1	Q08D86	51.9	528	571	528	3.71e-199	570	GLPK5_BOVIN	Glycerol kinase 5 (GK 5) (Glycerokinase 5) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 5)	Bos taurus (Bovine)	glycerol catabolic process [GO:0019563]; glycerol-3-phosphate biosynthetic process [GO:0046167]; triglyceride metabolic process [GO:0006641]	glycerol kinase activity [GO:0004370]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0004370; GO:0005737; GO:0005739; GO:0006641; GO:0019563; GO:0046167
GN020625	GN020625.1	Q8BMB3	67.7	220	296	245	1.59e-107	315	IF4E2_MOUSE	Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (eIF4E-2) (mRNA cap-binding protein type 2) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP)	Mus musculus (Mouse)	in utero embryonic development [GO:0001701]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; rescue of stalled cytosolic ribosome [GO:0072344]; translational initiation [GO:0006413]; type I interferon-mediated signaling pathway [GO:0060337]	mRNA cap binding [GO:0098808]; RNA 7-methylguanosine cap binding [GO:0000340]; translation initiation factor activity [GO:0003743]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; mitochondrion [GO:0005739]; P-body [GO:0000932]	GO:0000340; GO:0000932; GO:0001701; GO:0003743; GO:0005737; GO:0005739; GO:0005829; GO:0006413; GO:0016281; GO:0017148; GO:0031625; GO:0035278; GO:0045947; GO:0060337; GO:0060339; GO:0072344; GO:0098808
GN020626	GN020626.1	Q7QH62	51.0	210	213	263	1.17e-45	155	MED4_ANOGA	Mediator of RNA polymerase II transcription subunit 4 (Mediator complex subunit 4)	Anopheles gambiae (African malaria mosquito)	regulation of transcription by RNA polymerase II [GO:0006357]	transcription coregulator activity [GO:0003712]	core mediator complex [GO:0070847]; mediator complex [GO:0016592]	GO:0003712; GO:0006357; GO:0016592; GO:0070847
GN020627	GN020627.1	Q2FTH0	65.2	247	250	248	1.00e-118	342	GPMA_METHJ	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11)	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]	phosphoglycerate mutase activity [GO:0004619]		GO:0004619; GO:0006094; GO:0006096
GN020631	GN020631.1	Q5R596	39.8	113	114	124	1.44e-13	65.1	PAIP2_PONAB	Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2)	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	negative regulation of translational initiation [GO:0045947]	mRNA regulatory element binding translation repressor activity [GO:0000900]	cytoplasm [GO:0005737]	GO:0000900; GO:0005737; GO:0045947
GN020632	GN020632.1	O00237	27.2	640	465	685	5.42e-58	206	RN103_HUMAN	E3 ubiquitin-protein ligase RNF103 (EC 2.3.2.27) (KF-1) (hKF-1) (RING finger protein 103) (RING-type E3 ubiquitin transferase RNF103) (Zinc finger protein 103 homolog) (Zfp-103)	Homo sapiens (Human)	central nervous system development [GO:0007417]; endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]	GO:0004842; GO:0005783; GO:0005789; GO:0007417; GO:0016567; GO:0036503; GO:0044322; GO:0061630; GO:1904380
GN020633	GN020633.1	Q6NWH1	60.8	102	374	508	4.31e-34	135	DCA10_DANRE	DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein ubiquitination [GO:0016567]		Cul4-RING E3 ubiquitin ligase complex [GO:0080008]	GO:0016567; GO:0080008
GN020634	GN020634.1	O18334	87.7	187	188	208	3.41e-110	316	RAB6_DROME	Ras-related protein Rab6 (Protein warthog)	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; compound eye morphogenesis [GO:0001745]; exocytosis [GO:0006887]; germarium-derived egg chamber formation [GO:0007293]; intra-Golgi vesicle-mediated transport [GO:0006891]; oocyte microtubule cytoskeleton polarization [GO:0008103]; phototransduction [GO:0007602]; pole plasm oskar mRNA localization [GO:0045451]; protein targeting to Golgi apparatus [GO:0140450]; R7 cell development [GO:0045467]; Rab protein signal transduction [GO:0032482]; receptor recycling [GO:0001881]; regulation of postsynaptic membrane potential [GO:0060078]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]; vesicle-mediated transport [GO:0016192]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; synapse [GO:0045202]	GO:0000139; GO:0001745; GO:0001881; GO:0003924; GO:0005525; GO:0005764; GO:0005776; GO:0005794; GO:0005829; GO:0006887; GO:0006890; GO:0006891; GO:0007293; GO:0007411; GO:0007602; GO:0008103; GO:0016192; GO:0031410; GO:0032482; GO:0042147; GO:0043025; GO:0043204; GO:0045202; GO:0045451; GO:0045467; GO:0060078; GO:0140450
GN020635	GN020635.1	P82596	41.1	95	127	155	2.11e-20	84.0	PLC_HALLA	Perlucin	Haliotis laevigata (Smooth Australian abalone)				
GN020641	GN020641.1	Q6PHN7	48.8	260	329	296	2.58e-84	259	TM164_MOUSE	Transmembrane protein 164 (Arachidonoyl ether phospholipid synthase)	Mus musculus (Mouse)	positive regulation of ferroptosis [GO:0160020]		membrane [GO:0016020]	GO:0016020; GO:0160020
GN020642	GN020642.1	P54106	44.4	196	224	241	5.19e-42	145	ICLN_XENLA	Methylosome subunit pICln (Chloride conductance regulatory protein ICln) (I(Cln))	Xenopus laevis (African clawed frog)	cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; mRNA cis splicing, via spliceosome [GO:0045292]; spliceosomal snRNP assembly [GO:0000387]		cytoskeleton [GO:0005856]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; plasma membrane [GO:0005886]; spliceosomal complex [GO:0005681]	GO:0000387; GO:0005634; GO:0005681; GO:0005829; GO:0005856; GO:0005886; GO:0006821; GO:0006884; GO:0034709; GO:0034715; GO:0045292
GN020648	GN020648.1	Q96T83	48.9	309	325	725	2.65e-79	258	SL9A7_HUMAN	Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Solute carrier family 9 member 7)	Homo sapiens (Human)	Golgi lumen acidification [GO:0061795]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]	potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]	GO:0000139; GO:0005802; GO:0005886; GO:0015385; GO:0015386; GO:0016020; GO:0035725; GO:0051453; GO:0055037; GO:0055038; GO:0061795; GO:0098719
GN020649	GN020649.1	Q8IVB4	50.0	310	369	645	1.02e-76	251	SL9A9_HUMAN	Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9)	Homo sapiens (Human)	defense response to bacterium [GO:0042742]; phagosome maturation [GO:0090382]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]	potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]	early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; late endosome membrane [GO:0031902]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]	GO:0005769; GO:0005886; GO:0015385; GO:0015386; GO:0030670; GO:0031901; GO:0031902; GO:0032009; GO:0035725; GO:0042742; GO:0051453; GO:0055037; GO:0055038; GO:0071805; GO:0090382; GO:0098719
GN020650	GN020650.1	Q9R0W9	31.0	336	400	494	2.66e-55	192	ACHA6_MOUSE	Neuronal acetylcholine receptor subunit alpha-6	Mus musculus (Mouse)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; cation channel complex [GO:0034703]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; neurotransmitter receptor complex [GO:0098878]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0014059; GO:0022848; GO:0030594; GO:0032991; GO:0034220; GO:0034703; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0098878; GO:0099171
GN020651	GN020651.1	Q9R0W9	31.3	313	414	494	1.52e-53	188	ACHA6_MOUSE	Neuronal acetylcholine receptor subunit alpha-6	Mus musculus (Mouse)	acetylcholine receptor signaling pathway [GO:0095500]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; neuromuscular synaptic transmission [GO:0007274]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; cation channel complex [GO:0034703]; dopaminergic synapse [GO:0098691]; neuron projection [GO:0043005]; neurotransmitter receptor complex [GO:0098878]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; synaptic membrane [GO:0097060]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0007274; GO:0014059; GO:0022848; GO:0030594; GO:0032991; GO:0034220; GO:0034703; GO:0035094; GO:0035095; GO:0042734; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500; GO:0097060; GO:0098691; GO:0098878; GO:0099171
GN020652	GN020652.1	Q99JL1	33.9	298	324	234	4.75e-43	151	SPEF1_MOUSE	Sperm flagella and cilia-associated protein 1 (Calponin-homology and microtubule-associated protein)	Mus musculus (Mouse)	axonemal central apparatus assembly [GO:1904158]; cell migration [GO:0016477]; cilium movement [GO:0003341]; filopodium assembly [GO:0046847]; lamellipodium assembly [GO:0030032]; microtubule bundle formation [GO:0001578]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of cytoskeleton organization [GO:0051493]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]	actin binding [GO:0003779]; microtubule binding [GO:0008017]	9+2 motile cilium [GO:0097729]; apical plasma membrane [GO:0016324]; axonemal central apparatus [GO:1990716]; axoneme [GO:0005930]; basolateral plasma membrane [GO:0016323]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microvillus [GO:0005902]; motile cilium [GO:0031514]; stress fiber [GO:0001725]	GO:0001578; GO:0001725; GO:0003341; GO:0003779; GO:0005737; GO:0005874; GO:0005902; GO:0005930; GO:0007026; GO:0008017; GO:0016323; GO:0016324; GO:0016477; GO:0030027; GO:0030032; GO:0030175; GO:0031514; GO:0046847; GO:0051493; GO:0097542; GO:0097729; GO:1904158; GO:1990716; GO:2000095
GN020653	GN020653.1	Q0IH24	40.9	242	950	229	6.62e-43	159	SPEF1_XENLA	Sperm flagella and cilia-associated protein 1	Xenopus laevis (African clawed frog)	axonemal central apparatus assembly [GO:1904158]; cell migration [GO:0016477]; cilium movement [GO:0003341]; filopodium assembly [GO:0046847]; lamellipodium assembly [GO:0030032]; microtubule bundle formation [GO:0001578]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of cytoskeleton organization [GO:0051493]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]	microtubule binding [GO:0008017]	9+2 motile cilium [GO:0097729]; apical plasma membrane [GO:0016324]; axonemal central apparatus [GO:1990716]; axoneme [GO:0005930]; basolateral plasma membrane [GO:0016323]; ciliary tip [GO:0097542]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microvillus [GO:0005902]	GO:0001578; GO:0003341; GO:0005874; GO:0005902; GO:0005930; GO:0007026; GO:0008017; GO:0016323; GO:0016324; GO:0016477; GO:0030027; GO:0030032; GO:0030175; GO:0046847; GO:0051493; GO:0097542; GO:0097729; GO:1904158; GO:1990716; GO:2000095
GN020654	GN020654.1	B0JZG0	40.5	528	659	649	1.32e-113	358	S23A2_XENTR	Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	L-ascorbic acid transmembrane transport [GO:0015882]	L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0005886; GO:0008520; GO:0015229; GO:0015882; GO:0016324
GN020655	GN020655.1	B0JZG0	40.9	487	516	649	2.86e-106	334	S23A2_XENTR	Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	L-ascorbic acid transmembrane transport [GO:0015882]	L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0005886; GO:0008520; GO:0015229; GO:0015882; GO:0016324
GN020656	GN020656.1	Q5TF39	28.6	409	542	518	3.80e-29	124	S60A2_HUMAN	Solute carrier family 60 member 2 (Major facilitator superfamily domain-containing protein 4B) (Sodium-dependent glucose transporter 1)	Homo sapiens (Human)	D-glucose import across plasma membrane [GO:0098708]	D-glucose:sodium symporter activity [GO:0005412]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]	GO:0005412; GO:0016324; GO:0031526; GO:0098708
GN020657	GN020657.1	Q8NB25	33.5	167	367	1140	3.32e-13	74.7	F184A_HUMAN	Protein FAM184A	Homo sapiens (Human)			centriolar satellite [GO:0034451]; ciliary basal body [GO:0036064]; extracellular region [GO:0005576]; P-body [GO:0000932]	GO:0000932; GO:0005576; GO:0034451; GO:0036064
GN020658	GN020658.1	Q9NWM0	37.5	533	487	555	1.59e-111	343	SMOX_HUMAN	Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1)	Homo sapiens (Human)	polyamine biosynthetic process [GO:0006596]; polyamine catabolic process [GO:0006598]; spermine catabolic process [GO:0046208]; xenobiotic metabolic process [GO:0006805]	spermine oxidase activity [GO:0052901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006596; GO:0006598; GO:0006805; GO:0031965; GO:0046208; GO:0052901
GN020659	GN020659.1	A5PLI4	53.8	251	281	343	1.28e-93	283	LR2BP_DANRE	LRP2-binding protein	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]	GO:0005737
GN020663	GN020663.1	A5PLI4	49.2	325	345	343	7.77e-107	319	LR2BP_DANRE	LRP2-binding protein	Danio rerio (Zebrafish) (Brachydanio rerio)			cytoplasm [GO:0005737]	GO:0005737
GN020664	GN020664.1	Q80ZE4	32.7	278	342	345	1.09e-37	140	PAQR7_MOUSE	Membrane progestin receptor alpha (mPR alpha) (Membrane progesterone P4 receptor alpha) (Membrane progesterone receptor alpha) (PPAR-gamma-induced liver protein) (Progesterone and adipoQ receptor family member 7) (Progestin and adipoQ receptor family member 7) (Progestin and adipoQ receptor family member VII)	Mus musculus (Mouse)	response to steroid hormone [GO:0048545]	nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]	plasma membrane [GO:0005886]	GO:0003707; GO:0005496; GO:0005886; GO:0048545
GN020665	GN020665.1	Q80ZE4	33.6	274	342	345	2.74e-39	145	PAQR7_MOUSE	Membrane progestin receptor alpha (mPR alpha) (Membrane progesterone P4 receptor alpha) (Membrane progesterone receptor alpha) (PPAR-gamma-induced liver protein) (Progesterone and adipoQ receptor family member 7) (Progestin and adipoQ receptor family member 7) (Progestin and adipoQ receptor family member VII)	Mus musculus (Mouse)	response to steroid hormone [GO:0048545]	nuclear steroid receptor activity [GO:0003707]; steroid binding [GO:0005496]	plasma membrane [GO:0005886]	GO:0003707; GO:0005496; GO:0005886; GO:0048545
GN020668	GN020668.1	Q3KP44	29.5	264	776	614	2.77e-26	118	ANR55_HUMAN	Ankyrin repeat domain-containing protein 55	Homo sapiens (Human)				
GN020669	GN020669.1	Q9NQW7	68.8	157	208	623	1.78e-73	236	XPP1_HUMAN	Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)	Homo sapiens (Human)	bradykinin catabolic process [GO:0010815]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]	aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0004177; GO:0005737; GO:0005829; GO:0006508; GO:0010815; GO:0030145; GO:0042803; GO:0043069; GO:0070006; GO:0070062
GN020671	GN020671.1	Q6P1B1	52.6	371	480	623	1.91e-128	389	XPP1_MOUSE	Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)	Mus musculus (Mouse)	bradykinin catabolic process [GO:0010815]; CARD8 inflammasome complex assembly [GO:0140633]; negative regulation of programmed cell death [GO:0043069]; proteolysis [GO:0006508]	aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0004177; GO:0005737; GO:0005829; GO:0006508; GO:0010815; GO:0030145; GO:0042803; GO:0043069; GO:0070006; GO:0140633
GN020672	GN020672.1	Q9JL27	33.2	274	318	347	5.36e-31	122	FUT2_MOUSE	Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase) (MFUT-II) (Secretory blood group protein 2) (Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.69) (Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2) (EC 2.4.1.344)	Mus musculus (Mouse)	glycoprotein biosynthetic process [GO:0009101]; oligosaccharide biosynthetic process [GO:0009312]; protein O-linked glycosylation via fucose [GO:0036066]	alpha-(1,2)-fucosyltransferase activity [GO:0031127]; fucosyltransferase activity [GO:0008417]; galactoside 2-alpha-L-fucosyltransferase activity [GO:0008107]	Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; plasma membrane [GO:0005886]	GO:0005794; GO:0005886; GO:0008107; GO:0008417; GO:0009101; GO:0009312; GO:0031127; GO:0032580; GO:0036066
GN020673	GN020673.1	P50532	68.3	167	198	1290	1.25e-67	227	SMC4_XENLA	Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome assembly protein XCAP-C) (Chromosome-associated protein C)	Xenopus laevis (African clawed frog)	mitotic chromosome condensation [GO:0007076]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	condensin complex [GO:0000796]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000796; GO:0005524; GO:0005634; GO:0005829; GO:0007076; GO:0016887
GN020674	GN020674.1	Q9NY64	42.9	462	464	477	8.84e-120	361	SL2A8_HUMAN	Solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8) (Glucose transporter type X1)	Homo sapiens (Human)	carbohydrate metabolic process [GO:0005975]; D-glucose transmembrane transport [GO:1904659]; dehydroascorbic acid transport [GO:0070837]; fructose transmembrane transport [GO:0015755]; hexose transmembrane transport [GO:0008645]; male meiosis I [GO:0007141]	D-glucose binding [GO:0005536]; D-glucose transmembrane transporter activity [GO:0055056]; dehydroascorbic acid transmembrane transporter activity [GO:0033300]; fructose transmembrane transporter activity [GO:0005353]	clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic vesicle membrane [GO:0030659]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]	GO:0005353; GO:0005536; GO:0005765; GO:0005886; GO:0005975; GO:0007141; GO:0008021; GO:0008645; GO:0015755; GO:0030659; GO:0030669; GO:0033300; GO:0055056; GO:0070837; GO:1904659
GN020675	GN020675.1	Q3ZC24	51.0	151	156	278	1.04e-44	150	MARH5_BOVIN	E3 ubiquitin-protein ligase MARCHF5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (RING-type E3 ubiquitin transferase MARCHF5)	Bos taurus (Bovine)	negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; positive regulation of cGAS/STING signaling pathway [GO:0141111]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein autoubiquitination [GO:0051865]; protein K27-linked ubiquitination [GO:0044314]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]; protein polyubiquitination [GO:0000209]; regulation of mitochondrial fission [GO:0090140]	GTPase binding [GO:0051020]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; mitochondrial outer membrane [GO:0005741]	GO:0000209; GO:0005741; GO:0005783; GO:0005789; GO:0008270; GO:0039532; GO:0044314; GO:0051020; GO:0051865; GO:0061630; GO:0070534; GO:0070585; GO:0070936; GO:0090140; GO:0090141; GO:0141111; GO:1900227
GN020677	GN020677.1	Q6DFJ9	42.1	247	314	384	3.50e-64	210	CCNJ_XENLA	Cyclin-J	Xenopus laevis (African clawed frog)		cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]	cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; microtubule organizing center [GO:0005815]	GO:0000307; GO:0005815; GO:0016538
GN020678	GN020678.1	Q96N64	53.6	112	733	755	1.58e-31	135	PWP2A_HUMAN	PWWP domain-containing protein 2A	Homo sapiens (Human)	chromatin remodeling [GO:0006338]; positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; regulation of transcriptional start site selection at RNA polymerase II promoter [GO:0001178]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone H3K36me3 reader activity [GO:0140003]; NuRD complex binding [GO:0120325]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001178; GO:0003682; GO:0005634; GO:0005654; GO:0006338; GO:0032968; GO:0042393; GO:0120325; GO:0140003
GN020685	GN020685.1	Q7TSC3	42.4	85	101	627	4.93e-16	75.1	NEK5_MOUSE	Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5)	Mus musculus (Mouse)	positive regulation of striated muscle cell differentiation [GO:0051155]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cilium [GO:0005929]; sperm flagellum [GO:0036126]	GO:0004672; GO:0004674; GO:0005524; GO:0005929; GO:0036126; GO:0051155; GO:0106310
GN020687	GN020687.1	Q29RL1	62.8	626	667	622	2.98e-271	760	CF206_BOVIN	Cilia- and flagella-associated protein 206	Bos taurus (Bovine)	axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; regulation of cilium beat frequency [GO:0003356]; regulation of flagellated sperm motility [GO:1901317]; sperm axoneme assembly [GO:0007288]		axoneme [GO:0005930]; ciliary basal body [GO:0036064]; motile cilium [GO:0031514]; radial spoke [GO:0001534]	GO:0001534; GO:0003341; GO:0003356; GO:0005930; GO:0007288; GO:0031514; GO:0035082; GO:0036064; GO:1901317
GN020688	GN020688.1	Q9H9B4	70.3	316	380	322	1.70e-156	446	SFXN1_HUMAN	Sideroflexin-1	Homo sapiens (Human)	L-alanine transport [GO:0015808]; L-serine transport [GO:0015825]; one-carbon metabolic process [GO:0006730]; serine import into mitochondrion [GO:0140300]	L-alanine transmembrane transporter activity [GO:0015180]; L-serine transmembrane transporter activity [GO:0015194]; monoatomic ion transmembrane transporter activity [GO:0015075]; transmembrane transporter activity [GO:0022857]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005739; GO:0005743; GO:0006730; GO:0015075; GO:0015180; GO:0015194; GO:0015808; GO:0015825; GO:0022857; GO:0140300
GN020689	GN020689.1	Q504G0	35.9	206	235	237	1.23e-35	129	TM127_DANRE	Transmembrane protein 127	Danio rerio (Zebrafish) (Brachydanio rerio)	negative regulation of cell population proliferation [GO:0008285]; negative regulation of TOR signaling [GO:0032007]; regulation of TOR signaling [GO:0032006]		membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0008285; GO:0016020; GO:0032006; GO:0032007
GN020690	GN020690.1	Q9H204	53.8	104	227	178	5.19e-30	112	MED28_HUMAN	Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)	Homo sapiens (Human)	positive regulation of transcription elongation by RNA polymerase II [GO:0032968]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; RNA polymerase II preinitiation complex assembly [GO:0051123]		core mediator complex [GO:0070847]; cortical actin cytoskeleton [GO:0030864]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0016020; GO:0016592; GO:0030864; GO:0032968; GO:0051123; GO:0060261; GO:0070847
GN020691	GN020691.1	Q28CF8	45.5	532	626	610	2.87e-151	452	ENTP7_XENTR	Ectonucleoside triphosphate diphosphohydrolase 7 (NTPDase 7) (EC 3.6.1.15)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	CTP catabolic process [GO:0006254]; CTP metabolic process [GO:0046036]; GTP metabolic process [GO:0046039]; nucleobase-containing small molecule catabolic process [GO:0034656]; UDP catabolic process [GO:0006256]; UTP catabolic process [GO:0046052]	CTPase activity [GO:0043273]; GDP phosphatase activity [GO:0004382]; GTPase activity [GO:0003924]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]	cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]	GO:0003924; GO:0004382; GO:0005794; GO:0006254; GO:0006256; GO:0016020; GO:0017111; GO:0030659; GO:0034656; GO:0043273; GO:0045134; GO:0046036; GO:0046039; GO:0046052
GN020692	GN020692.1	Q8VC51	48.9	272	394	532	1.19e-85	273	TCAB1_MOUSE	Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene homolog)	Mus musculus (Mouse)	Cajal body organization [GO:0030576]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein localization to Cajal body [GO:1904867]; RNA folding [GO:0034337]; scaRNA localization to Cajal body [GO:0090666]; telomerase RNA localization to Cajal body [GO:0090671]; telomere formation via telomerase [GO:0032203]; telomere maintenance via telomerase [GO:0007004]	histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein carrier activity [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; RNA folding chaperone [GO:0140691]; telomerase RNA binding [GO:0070034]; ubiquitin protein ligase binding [GO:0031625]	Cajal body [GO:0015030]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; postsynaptic density membrane [GO:0098839]; site of double-strand break [GO:0035861]; telomerase holoenzyme complex [GO:0005697]	GO:0000781; GO:0003723; GO:0005654; GO:0005694; GO:0005697; GO:0005829; GO:0007004; GO:0015030; GO:0016604; GO:0030576; GO:0031625; GO:0032203; GO:0032212; GO:0034337; GO:0035861; GO:0042393; GO:0042802; GO:0044877; GO:0045739; GO:0051087; GO:0070034; GO:0090666; GO:0090671; GO:0098839; GO:0098978; GO:0140597; GO:0140691; GO:1904851; GO:1904867; GO:1905168; GO:2000781; GO:2001034
GN020693	GN020693.1	Q9BUR4	42.4	66	108	548	1.03e-09	57.4	TCAB1_HUMAN	Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta)	Homo sapiens (Human)	Cajal body organization [GO:0030576]; positive regulation of DNA repair [GO:0045739]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein localization to Cajal body [GO:1904867]; RNA folding [GO:0034337]; scaRNA localization to Cajal body [GO:0090666]; telomerase RNA localization to Cajal body [GO:0090671]; telomere formation via telomerase [GO:0032203]; telomere maintenance via telomerase [GO:0007004]	histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein carrier activity [GO:0140597]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; RNA binding [GO:0003723]; RNA folding chaperone [GO:0140691]; telomerase RNA binding [GO:0070034]; ubiquitin protein ligase binding [GO:0031625]	Cajal body [GO:0015030]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; telomerase holoenzyme complex [GO:0005697]	GO:0000781; GO:0003723; GO:0005654; GO:0005694; GO:0005697; GO:0005829; GO:0007004; GO:0015030; GO:0016604; GO:0030576; GO:0031625; GO:0032203; GO:0032212; GO:0034337; GO:0035861; GO:0042393; GO:0042802; GO:0044877; GO:0045739; GO:0051087; GO:0070034; GO:0090666; GO:0090671; GO:0140597; GO:0140691; GO:1904851; GO:1904867; GO:1905168; GO:2000781; GO:2001034
GN020694	GN020694.1	Q3T0S0	38.5	96	203	165	1.30e-12	66.2	TM128_BOVIN	Transmembrane protein 128	Bos taurus (Bovine)			membrane [GO:0016020]	GO:0016020
GN020695	GN020695.1	Q58HI1	27.4	547	834	1012	1.02e-41	168	PELP1_XENLA	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor)	Xenopus laevis (African clawed frog)	cellular response to estrogen stimulus [GO:0071391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; rRNA processing [GO:0006364]	chromatin binding [GO:0003682]	cytoplasm [GO:0005737]; euchromatin [GO:0000791]; MLL1 complex [GO:0071339]; nucleus [GO:0005634]	GO:0000791; GO:0003682; GO:0005634; GO:0005737; GO:0006364; GO:0045944; GO:0071339; GO:0071391
GN020696	GN020696.1	Q0E908	29.3	492	1187	818	5.39e-56	213	HIL_DROME	Hillarin (D-Hillarin) (D-hil)	Drosophila melanogaster (Fruit fly)			cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]	GO:0005737; GO:0005938; GO:0032154
GN020697	GN020697.1	Q5ZLH4	63.9	119	115	120	1.79e-46	148	TM230_CHICK	Transmembrane protein 230	Gallus gallus (Chicken)	axonal transport [GO:0098930]; synaptic vesicle transport [GO:0048489]		autophagosome [GO:0005776]; axon [GO:0030424]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; late endosome [GO:0005770]; membrane [GO:0016020]; recycling endosome [GO:0055037]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]	GO:0005769; GO:0005770; GO:0005776; GO:0005802; GO:0008021; GO:0012505; GO:0016020; GO:0030424; GO:0048489; GO:0055037; GO:0098930
GN020701	GN020701.1	Q8IS64	31.4	746	823	727	2.57e-119	380	ECE_LOCMI	Endothelin-converting enzyme homolog (ECE) (EC 3.4.24.-)	Locusta migratoria (Migratory locust)	protein processing [GO:0016485]	endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]	plasma membrane [GO:0005886]	GO:0004175; GO:0004222; GO:0005886; GO:0008270; GO:0016485
GN020703	GN020703.1	Q28F51	46.5	159	211	409	8.19e-29	114	TADBP_XENTR	TAR DNA-binding protein 43 (TDP-43)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of protein stability [GO:0031647]; RNA splicing [GO:0008380]	double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0003690; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0008380; GO:0010468; GO:0010494; GO:0031647; GO:0042752
GN020704	GN020704.1	Q8BZW8	46.1	627	622	725	1.85e-186	546	NHLC2_MOUSE	NHL repeat-containing protein 2	Mus musculus (Mouse)			cytosol [GO:0005829]	GO:0005829
GN020706	GN020706.1	Q18120	25.4	346	548	461	2.59e-19	94.4	TWK18_CAEEL	TWiK family of potassium channels protein 18	Caenorhabditis elegans	locomotion [GO:0040011]; muscle contraction [GO:0006936]; potassium ion transport [GO:0006813]	outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005886; GO:0006813; GO:0006936; GO:0015271; GO:0016020; GO:0022841; GO:0040011
GN020710	GN020710.1	Q95JJ0	37.8	323	338	350	1.75e-59	197	SG196_MACFA	Protein O-mannose kinase (POMK) (EC 2.7.1.183) (Protein kinase-like protein SgK196) (Sugen kinase 196)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	carbohydrate phosphorylation [GO:0046835]; protein O-linked glycosylation [GO:0006493]	ATP binding [GO:0005524]; carbohydrate kinase activity [GO:0019200]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; protein kinase activity [GO:0004672]	endoplasmic reticulum membrane [GO:0005789]	GO:0004672; GO:0005524; GO:0005789; GO:0006493; GO:0016773; GO:0019200; GO:0046835
GN020712	GN020712.1	Q95JJ0	37.8	323	338	350	1.75e-59	197	SG196_MACFA	Protein O-mannose kinase (POMK) (EC 2.7.1.183) (Protein kinase-like protein SgK196) (Sugen kinase 196)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	carbohydrate phosphorylation [GO:0046835]; protein O-linked glycosylation [GO:0006493]	ATP binding [GO:0005524]; carbohydrate kinase activity [GO:0019200]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; protein kinase activity [GO:0004672]	endoplasmic reticulum membrane [GO:0005789]	GO:0004672; GO:0005524; GO:0005789; GO:0006493; GO:0016773; GO:0019200; GO:0046835
GN020717	GN020717.1	Q20929	34.4	157	211	510	2.52e-18	85.9	DMSR1_CAEEL	G protein-coupled receptor dmsr-1 (Dromyosuppressin receptor related 1)	Caenorhabditis elegans	G protein-coupled receptor signaling pathway [GO:0007186]; regulation of cellular response to heat [GO:1900034]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]	G protein-coupled peptide receptor activity [GO:0008528]; neuropeptide receptor activity [GO:0008188]	neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008188; GO:0008528; GO:0032809; GO:0045187; GO:1900034
GN020722	GN020722.1	Q8C9M2	44.9	176	452	810	1.58e-29	125	CCD15_MOUSE	Coiled-coil domain-containing protein 15	Mus musculus (Mouse)	cilium assembly [GO:0060271]; positive regulation of centriole elongation [GO:1903724]		centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]	GO:0005813; GO:0005814; GO:0034451; GO:0060271; GO:1903724
GN020731	GN020731.1	Q96FG2	49.2	266	625	381	5.85e-86	276	ELMD3_HUMAN	ELMO domain-containing protein 3 (RNA-binding motif and ELMO domain-containing protein 1) (RNA-binding motif protein 29) (RNA-binding protein 29)	Homo sapiens (Human)	cilium assembly [GO:0060271]		cilium [GO:0005929]; Golgi apparatus [GO:0005794]; kinocilium [GO:0060091]; stereocilium [GO:0032420]	GO:0005794; GO:0005929; GO:0032420; GO:0060091; GO:0060271
GN020735	GN020735.1	Q99JW4	70.1	318	388	325	1.55e-183	514	LIMS1_MOUSE	LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1)	Mus musculus (Mouse)	actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; cell-cell adhesion [GO:0098609]; cell-cell junction organization [GO:0045216]; cell-matrix adhesion [GO:0007160]; chordate embryonic development [GO:0043009]; establishment of protein localization [GO:0045184]; establishment or maintenance of cell polarity [GO:0007163]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of neural precursor cell proliferation [GO:2000178]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; tumor necrosis factor-mediated signaling pathway [GO:0033209]	protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; zinc ion binding [GO:0008270]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]	GO:0005737; GO:0005886; GO:0005911; GO:0005925; GO:0007160; GO:0007163; GO:0008270; GO:0010628; GO:0010811; GO:0019901; GO:0032991; GO:0033209; GO:0043009; GO:0043066; GO:0043123; GO:0044877; GO:0045184; GO:0045216; GO:0045892; GO:0048471; GO:0050680; GO:0051017; GO:0051639; GO:0051894; GO:0098609; GO:1900026; GO:2000178; GO:2000346; GO:2001046
GN020736	GN020736.1	P47805	33.6	140	165	152	2.98e-13	66.6	M1I1A_DANRE	Mid1-interacting protein 1A (Gastrulation-specific protein G12)	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of lipid biosynthetic process [GO:0046890]		cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0005856; GO:0046890
GN020737	GN020737.1	O15484	45.9	486	488	640	2.90e-137	412	CAN5_HUMAN	Calpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3)	Homo sapiens (Human)	proteolysis [GO:0006508]; signal transduction [GO:0007165]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; synapse [GO:0045202]	GO:0004198; GO:0005737; GO:0005925; GO:0006508; GO:0007165; GO:0009986; GO:0045202; GO:0070062
GN020740	GN020740.1	Q9J4Z4	30.6	180	434	592	5.67e-12	71.2	V246_FOWPN	Putative ankyrin repeat protein FPV246	Fowlpox virus (strain NVSL) (FPV)				
GN020741	GN020741.1	Q6AZV0	43.9	98	228	152	1.40e-22	92.8	DHSDB_XENLA	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial (CybS-B) (Malate dehydrogenase [quinone] cytochrome b small subunit) (Succinate dehydrogenase complex subunit D-B) (Succinate-ubiquinone oxidoreductase cytochrome b small subunit B) (Succinate-ubiquinone reductase membrane anchor subunit B)	Xenopus laevis (African clawed frog)	mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; tricarboxylic acid cycle [GO:0006099]	heme binding [GO:0020037]; ubiquinone binding [GO:0048039]	mitochondrial inner membrane [GO:0005743]; respiratory chain complex II (succinate dehydrogenase) [GO:0045273]	GO:0005743; GO:0006099; GO:0006121; GO:0020037; GO:0045273; GO:0048039
GN020743	GN020743.1	Q708S5	30.8	419	471	533	2.19e-38	149	ASIC2_DANRE	Acid-sensing ion channel 2 (ASIC2) (ZASIC2)	Danio rerio (Zebrafish) (Brachydanio rerio)	response to steroid hormone [GO:0048545]; sodium ion transmembrane transport [GO:0035725]	pH-gated sodium channel activity [GO:0160125]	plasma membrane [GO:0005886]	GO:0005886; GO:0035725; GO:0048545; GO:0160125
GN020746	GN020746.1	O43301	49.9	483	462	675	5.11e-159	468	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN020747	GN020747.1	Q96MM6	73.0	89	923	686	5.91e-36	149	HS12B_HUMAN	Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B)	Homo sapiens (Human)				
GN020752	GN020752.1	P83829	53.9	653	681	675	1.47e-223	642	IFT81_RAT	Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1)	Rattus norvegicus (Rat)	cilium assembly [GO:0060271]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium assembly [GO:0035735]; regulation of smoothened signaling pathway [GO:0008589]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283]	tubulin binding [GO:0015631]	centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; intraciliary transport particle A [GO:0030991]; intraciliary transport particle B [GO:0030992]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0005737; GO:0005813; GO:0005814; GO:0005929; GO:0007283; GO:0008589; GO:0015631; GO:0030991; GO:0030992; GO:0035735; GO:0036064; GO:0042073; GO:0060271; GO:0097225; GO:0097228; GO:0120316
GN020753	GN020753.1	Q498J9	46.4	194	234	233	3.60e-49	164	MBLC1_XENLA	Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1)	Xenopus laevis (African clawed frog)	histone mRNA metabolic process [GO:0008334]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]	metal ion binding [GO:0046872]; RNA endonuclease activity [GO:0004521]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0008334; GO:0046872; GO:1900087
GN020754	GN020754.1	Q92113	32.4	500	484	509	2.03e-71	238	CP17A_SQUAC	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)	Squalus acanthias (Spiny dogfish)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid biosynthetic process [GO:0006694]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	membrane [GO:0016020]	GO:0004508; GO:0005506; GO:0006694; GO:0016020; GO:0020037; GO:0042446; GO:0042448
GN020755	GN020755.1	Q8BVE8	43.2	1123	1321	1365	1.25e-300	887	NSD2_MOUSE	Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Wolf-Hirschhorn syndrome candidate 1 protein homolog)	Mus musculus (Mouse)	atrial septum primum morphogenesis [GO:0003289]; atrial septum secundum morphogenesis [GO:0003290]; bone development [GO:0060348]; membranous septum morphogenesis [GO:0003149]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of establishment of protein localization [GO:0070201]	chromatin binding [GO:0003682]; histone H3K36 dimethyltransferase activity [GO:0140954]; histone H3K36 methyltransferase activity [GO:0046975]; histone H3K36 trimethyltransferase activity [GO:0140955]; histone methyltransferase activity [GO:0042054]; sequence-specific DNA binding [GO:0043565]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0003149; GO:0003289; GO:0003290; GO:0003682; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006355; GO:0042054; GO:0043565; GO:0046975; GO:0048298; GO:0060348; GO:0070201; GO:0140954; GO:0140955; GO:2001032
GN020756	GN020756.1	A0JPG1	44.6	635	636	744	3.79e-166	496	FHI2A_XENLA	FHF complex subunit HOOK interacting protein 2A (FHIP2A)	Xenopus laevis (African clawed frog)				
GN020757	GN020757.1	Q6P7N1	70.6	214	285	300	1.37e-86	263	MAK16_XENTR	Protein MAK16 homolog (MAK16-like protein)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]		nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]	GO:0000460; GO:0000470; GO:0005730; GO:0030687
GN020758	GN020758.1	Q6GPF3	77.5	693	714	768	0.0	1065	CUL3B_XENLA	Cullin-3-B (CUL-3-B)	Xenopus laevis (African clawed frog)	apoptotic process [GO:0006915]; cell migration [GO:0016477]; COPII vesicle coating [GO:0048208]; embryonic cleavage [GO:0040016]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; integrin-mediated signaling pathway [GO:0007229]; mitotic metaphase chromosome alignment [GO:0007080]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of mitotic cell cycle phase transition [GO:1901992]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of gene expression [GO:0010468]; response to stress [GO:0006950]; stem cell division [GO:0017145]; stress fiber assembly [GO:0043149]	ubiquitin ligase complex scaffold activity [GO:0160072]; ubiquitin protein ligase binding [GO:0031625]	centrosome [GO:0005813]; Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; mitotic spindle [GO:0072686]; nucleus [GO:0005634]; polar microtubule [GO:0005827]; spindle pole [GO:0000922]	GO:0000209; GO:0000922; GO:0005634; GO:0005737; GO:0005813; GO:0005827; GO:0006513; GO:0006888; GO:0006915; GO:0006950; GO:0007080; GO:0007229; GO:0010468; GO:0016477; GO:0016567; GO:0017145; GO:0031463; GO:0031625; GO:0035024; GO:0040016; GO:0043149; GO:0043161; GO:0045842; GO:0048208; GO:0072686; GO:0160072; GO:1901992
GN020760	GN020760.1	P49701	31.3	368	419	448	8.13e-32	129	VDR_COTJA	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)	Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)	cell differentiation [GO:0030154]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; vitamin D receptor signaling pathway [GO:0070561]	nuclear receptor activity [GO:0004879]; vitamin D response element binding [GO:0070644]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000122; GO:0004879; GO:0005634; GO:0005737; GO:0008270; GO:0030154; GO:0045944; GO:0070561; GO:0070644
GN020761	GN020761.1	A2RU49	35.6	362	377	373	6.27e-68	221	HYKK_HUMAN	Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1)	Homo sapiens (Human)	L-lysine catabolic process [GO:0019477]	amino acid kinase activity [GO:0019202]; hydroxylysine kinase activity [GO:0047992]	mitochondrial matrix [GO:0005759]	GO:0005759; GO:0019202; GO:0019477; GO:0047992
GN020765	GN020765.1	A0A1L8GXY4	36.2	1745	2066	1621	0.0	1011	CFA43_XENLA	Cilia- and flagella-associated protein 43	Xenopus laevis (African clawed frog)	epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; regulation of cilium beat frequency [GO:0003356]; sperm axoneme assembly [GO:0007288]		axoneme [GO:0005930]; extracellular region [GO:0005576]	GO:0003351; GO:0003356; GO:0005576; GO:0005930; GO:0007288
GN020766	GN020766.1	Q9D8Z1	47.4	194	197	356	1.77e-55	182	ASCC1_MOUSE	Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50)	Mus musculus (Mouse)	regulation of DNA-templated transcription [GO:0006355]	RNA binding [GO:0003723]	DNA repair complex [GO:1990391]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0003723; GO:0005634; GO:0005667; GO:0006355; GO:0016607; GO:1990391
GN020767	GN020767.1	F1QEB7	39.7	58	67	1239	5.20e-09	53.5	WDR11_DANRE	WD repeat-containing protein 11	Danio rerio (Zebrafish) (Brachydanio rerio)	cilium assembly [GO:0060271]; head development [GO:0060322]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; multicellular organism growth [GO:0035264]; neural crest cell migration [GO:0001755]; regulation of smoothened signaling pathway [GO:0008589]; vesicle tethering to Golgi [GO:0099041]		axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]	GO:0001755; GO:0005634; GO:0005737; GO:0005802; GO:0005930; GO:0006886; GO:0007507; GO:0008589; GO:0031410; GO:0035264; GO:0036064; GO:0060271; GO:0060322; GO:0099041
GN020768	GN020768.1	Q9X6U2	40.5	259	436	258	3.61e-56	189	BDHA_CUPNH	D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (3-HBDH)	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha)	lipid metabolic process [GO:0006629]; monocarboxylic acid metabolic process [GO:0032787]	3-hydroxybutyrate dehydrogenase activity [GO:0003858]		GO:0003858; GO:0006629; GO:0032787
GN020769	GN020769.1	Q3UZY0	40.1	955	1415	1216	1.61e-49	196	SFI1_MOUSE	Protein SFI1 homolog	Mus musculus (Mouse)		phosphatase binding [GO:0019902]	centriole [GO:0005814]	GO:0005814; GO:0019902
GN020770	GN020770.1	B0JZG0	45.4	549	755	649	6.97e-150	455	S23A2_XENTR	Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	L-ascorbic acid transmembrane transport [GO:0015882]	L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]	apical plasma membrane [GO:0016324]; plasma membrane [GO:0005886]	GO:0005886; GO:0008520; GO:0015229; GO:0015882; GO:0016324
GN020771	GN020771.1	B0DZL3	33.9	186	291	642	1.20e-23	103	AMPP1_LACBS	Probable Xaa-Pro aminopeptidase P (AMPP) (Aminopeptidase P) (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Prolidase)	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)		metalloaminopeptidase activity [GO:0070006]	cytoplasm [GO:0005737]	GO:0005737; GO:0070006
GN020772	GN020772.1	A0A1S4GHV7	43.9	376	432	493	4.08e-98	305	FUTA_ANOGA	Core alpha-(1,3)-fucosyltransferase (EC 2.4.1.214) (Fucosyltransferase A) (AgFucTA)	Anopheles gambiae (African malaria mosquito)	N-glycan processing [GO:0006491]	glycoprotein 3-alpha-L-fucosyltransferase activity [GO:0018392]	Golgi cisterna membrane [GO:0032580]	GO:0006491; GO:0018392; GO:0032580
GN020773	GN020773.1	P16066	53.2	252	615	1061	9.03e-71	250	ANPRA_HUMAN	Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)	Homo sapiens (Human)	blood vessel diameter maintenance [GO:0097746]; body fluid secretion [GO:0007589]; cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of urine volume [GO:0035810]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of vascular permeability [GO:0043114]	ATP binding [GO:0005524]; G protein-coupled peptide receptor activity [GO:0008528]; guanylate cyclase activity [GO:0004383]; hormone binding [GO:0042562]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; peptide receptor activity [GO:0001653]; protein kinase activity [GO:0004672]	ANPR-A receptor complex [GO:1990620]; endoplasmic reticulum membrane [GO:0005789]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; signaling receptor complex [GO:0043235]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005789; GO:0005886; GO:0006182; GO:0007166; GO:0007168; GO:0007589; GO:0008217; GO:0008528; GO:0016525; GO:0016941; GO:0017046; GO:0030308; GO:0031965; GO:0035556; GO:0035810; GO:0035815; GO:0042417; GO:0042562; GO:0043114; GO:0043235; GO:0048662; GO:0097746; GO:1990620
GN020774	GN020774.1	P46197	58.5	212	847	1047	4.48e-66	242	ANPRB_BOVIN	Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B)	Bos taurus (Bovine)	cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; identical protein binding [GO:0042802]; natriuretic peptide receptor activity [GO:0016941]; peptide hormone binding [GO:0017046]; protein kinase activity [GO:0004672]	plasma membrane [GO:0005886]	GO:0004383; GO:0004672; GO:0005524; GO:0005886; GO:0006182; GO:0007168; GO:0016941; GO:0017046; GO:0035556; GO:0042802
GN020778	GN020778.1	Q9W0Y2	44.4	135	160	157	2.55e-31	113	YS11_DROME	Putative gamma-glutamylcyclotransferase CG2811 (EC 2.3.2.-)	Drosophila melanogaster (Fruit fly)		gamma-glutamylaminecyclotransferase activity [GO:0061929]	cytosol [GO:0005829]	GO:0005829; GO:0061929
GN020779	GN020779.1	Q5I0S6	66.0	297	303	312	1.03e-130	377	ATG3_XENTR	Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; glycophagy [GO:0061723]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; nucleophagy [GO:0044804]	Atg12 transferase activity [GO:0019777]; Atg8-family conjugating enzyme activity [GO:0141046]; Atg8-family ligase activity [GO:0019776]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]	GO:0000045; GO:0000407; GO:0000422; GO:0005737; GO:0005829; GO:0006914; GO:0019776; GO:0019777; GO:0043653; GO:0044804; GO:0061723; GO:0141046
GN020781	GN020781.1	P91891	75.7	342	339	339	2.01e-172	485	MO25_DROME	Protein Mo25 (dMo25)	Drosophila melanogaster (Fruit fly)	intracellular signal transduction [GO:0035556]; positive regulation of TORC1 signaling [GO:1904263]	protein serine/threonine kinase activator activity [GO:0043539]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; serine/threonine protein kinase complex [GO:1902554]	GO:0005634; GO:0005737; GO:0035556; GO:0043539; GO:1902554; GO:1904263
GN020782	GN020782.1	P49326	35.8	511	527	533	6.41e-89	286	FMO5_HUMAN	Flavin-containing monooxygenase 5 (FMO 5) (Baeyer-Villiger monooxygenase 1) (hBVMO1) (EC 1.14.13.-) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (NADPH oxidase) (EC 1.6.3.1)	Homo sapiens (Human)	regulation of cholesterol metabolic process [GO:0090181]; xenobiotic metabolic process [GO:0006805]	flavin adenine dinucleotide binding [GO:0050660]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NAD(P)H oxidase H2O2-forming activity [GO:0016174]; NADP binding [GO:0050661]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0004497; GO:0004499; GO:0005783; GO:0005789; GO:0006805; GO:0016174; GO:0050660; GO:0050661; GO:0090181
GN020783	GN020783.1	Q27968	51.4	488	496	504	1.90e-158	462	DNJC3_BOVIN	DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)	Bos taurus (Bovine)	cellular response to cold [GO:0070417]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; positive regulation of translation initiation in response to endoplasmic reticulum stress [GO:0036494]; protein folding in endoplasmic reticulum [GO:0034975]	misfolded protein binding [GO:0051787]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; protein-folding chaperone binding [GO:0051087]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]	GO:0004860; GO:0005783; GO:0005829; GO:0019901; GO:0034975; GO:0036494; GO:0051087; GO:0051787; GO:0070417; GO:1903912
GN020784	GN020784.1	Q8BMD2	44.9	167	915	852	7.74e-32	137	DZIP1_MOUSE	Cilium assembly protein DZIP1 (DAZ-interacting protein 1 homolog) (DAZ-interacting zinc finger protein 1)	Mus musculus (Mouse)	ciliary basal body organization [GO:0032053]; cilium assembly [GO:0060271]; cilium organization [GO:0044782]; establishment of protein localization [GO:0045184]; heart development [GO:0007507]; positive regulation of cilium assembly [GO:0045724]; positive regulation of protein localization to cilium [GO:1903566]; protein localization to cilium [GO:0061512]; protein-containing complex localization to centriolar satellite [GO:0140706]; smoothened signaling pathway [GO:0007224]; sperm flagellum assembly [GO:0120316]; spermatogenesis [GO:0007283]	BBSome binding [GO:0062063]; molecular adaptor activity [GO:0060090]; protein sequestering activity [GO:0140311]	centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; ciliary transition fiber [GO:0097539]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0007224; GO:0007283; GO:0007507; GO:0016607; GO:0032053; GO:0034451; GO:0036064; GO:0044782; GO:0045184; GO:0045724; GO:0060090; GO:0060271; GO:0061512; GO:0062063; GO:0097539; GO:0097546; GO:0120316; GO:0140311; GO:0140706; GO:1903566
GN020786	GN020786.1	Q9QZC7	37.6	170	173	221	2.35e-29	110	PKHB2_MOUSE	Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2)	Mus musculus (Mouse)	regulation of cell differentiation [GO:0045595]	phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]	membrane [GO:0016020]; recycling endosome membrane [GO:0055038]	GO:0005547; GO:0016020; GO:0045595; GO:0055038
GN020787	GN020787.1	Q9Y5K3	55.8	301	424	369	9.37e-98	300	PCY1B_HUMAN	Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B)	Homo sapiens (Human)	CDP-choline pathway [GO:0006657]; phosphatidylcholine biosynthetic process [GO:0006656]	choline-phosphate cytidylyltransferase activity [GO:0004105]; identical protein binding [GO:0042802]; phosphatidylcholine binding [GO:0031210]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0004105; GO:0005737; GO:0005783; GO:0005789; GO:0006656; GO:0006657; GO:0031210; GO:0042802
GN020788	GN020788.1	Q8BGC3	27.8	558	597	486	1.40e-70	238	MOT12_MOUSE	Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12)	Mus musculus (Mouse)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; transmembrane transporter activity [GO:0022857]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0022857; GO:0046449
GN020791	GN020791.1	Q8K2Q9	26.0	327	367	631	7.56e-17	85.5	SHOT1_MOUSE	Shootin-1 (Shootin1)	Mus musculus (Mouse)	actin filament bundle retrograde transport [GO:0061573]; axonogenesis [GO:0007409]; Cdc42 protein signal transduction [GO:0032488]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; endoplasmic reticulum polarization [GO:0061163]; membrane depolarization [GO:0051899]; netrin-activated signaling pathway [GO:0038007]; neuron projection morphogenesis [GO:0048812]; positive regulation of axon extension [GO:0045773]; positive regulation of neuron migration [GO:2001224]; Ras protein signal transduction [GO:0007265]; regulation of establishment of cell polarity [GO:2000114]; regulation of neuron migration [GO:2001222]; substrate-dependent cell migration, cell extension [GO:0006930]	actin filament binding [GO:0051015]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]	axon [GO:0030424]; axonal growth cone [GO:0044295]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]	GO:0005737; GO:0005874; GO:0005875; GO:0006930; GO:0007265; GO:0007409; GO:0015630; GO:0019894; GO:0030027; GO:0030175; GO:0030424; GO:0030426; GO:0031252; GO:0032488; GO:0038007; GO:0042802; GO:0043204; GO:0044295; GO:0045773; GO:0048471; GO:0048812; GO:0050839; GO:0051015; GO:0051899; GO:0060327; GO:0061163; GO:0061573; GO:2000114; GO:2001222; GO:2001224
GN020792	GN020792.1	Q91854	72.5	160	183	518	2.02e-80	250	TRCB_XENLA	Beta-TrCP (Beta-transducin repeat-containing protein)	Xenopus laevis (African clawed frog)	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	beta-catenin binding [GO:0008013]; phosphoprotein binding [GO:0051219]; protein dimerization activity [GO:0046983]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	SCF ubiquitin ligase complex [GO:0019005]	GO:0008013; GO:0019005; GO:0031146; GO:0046983; GO:0051219; GO:1990756
GN020793	GN020793.1	Q9H1Q7	47.9	190	433	454	1.94e-61	209	PED1A_HUMAN	PC-esterase domain-containing protein 1A (Protein FAM113A) (Sarcoma antigen NY-SAR-23)	Homo sapiens (Human)				
GN020794	GN020794.1	Q6GM59	27.3	381	366	460	1.37e-48	173	MOT12_XENLA	Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12)	Xenopus laevis (African clawed frog)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; transmembrane transporter activity [GO:0022857]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0022857; GO:0046449
GN020797	GN020797.1	Q86WZ0	31.6	670	1285	1026	1.77e-77	281	HEAT4_HUMAN	HEAT repeat-containing protein 4	Homo sapiens (Human)		oxidoreductase activity [GO:0016491]		GO:0016491
GN020798	GN020798.1	Q06453	47.4	190	329	408	9.95e-38	142	AL_DROME	Homeobox protein aristaless	Drosophila melanogaster (Fruit fly)	antennal morphogenesis [GO:0048800]; chaeta development [GO:0022416]; elongation of arista core [GO:0035015]; imaginal disc-derived leg morphogenesis [GO:0007480]; leg disc development [GO:0035218]; negative regulation of DNA-templated transcription [GO:0045892]; neuron development [GO:0048666]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0007480; GO:0022416; GO:0032991; GO:0035015; GO:0035218; GO:0045892; GO:0048666; GO:0048800
GN020799	GN020799.1	Q503M4	27.1	457	541	477	3.34e-33	135	MT12B_DANRE	Monocarboxylate transporter 12-B (MCT 12-B) (Solute carrier family 16 member 12-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; transmembrane transporter activity [GO:0022857]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0022857; GO:0046449
GN020801	GN020801.1	B0R0T1	54.6	1876	2243	1896	0.0	1939	VWA8_DANRE	von Willebrand factor A domain-containing protein 8	Danio rerio (Zebrafish) (Brachydanio rerio)	notochord development [GO:0030903]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]	cytoplasm [GO:0005737]; mitochondrion [GO:0005739]	GO:0005524; GO:0005737; GO:0005739; GO:0016887; GO:0030903
GN020802	GN020802.1	Q9P2Z0	37.2	86	364	257	2.93e-13	72.4	THA10_HUMAN	THAP domain-containing protein 10	Homo sapiens (Human)		sequence-specific DNA binding [GO:0043565]		GO:0043565
GN020803	GN020803.1	Q9Z306	31.4	414	539	553	4.43e-61	213	S22A4_MOUSE	Solute carrier family 22 member 4 (Organic cation/carnitine transporter 1) (Octn1)	Mus musculus (Mouse)	acetylcholine uptake [GO:0051630]; amino acid import across plasma membrane [GO:0089718]; carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879]; lactation [GO:0007595]; liver regeneration [GO:0097421]; quaternary ammonium group transport [GO:0015697]; response to exogenous dsRNA [GO:0043330]; response to lipopolysaccharide [GO:0032496]; response to vitamin D [GO:0033280]; sodium-independent organic anion transport [GO:0043252]; sulfur amino acid transport [GO:0000101]; triglyceride metabolic process [GO:0006641]; xenobiotic transport [GO:0042908]	acetylcholine transmembrane transporter activity [GO:0005277]; amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]	GO:0000101; GO:0005277; GO:0005739; GO:0006641; GO:0007595; GO:0009437; GO:0009925; GO:0015171; GO:0015199; GO:0015226; GO:0015651; GO:0015697; GO:0015879; GO:0016324; GO:0030165; GO:0031966; GO:0032496; GO:0033280; GO:0042908; GO:0043025; GO:0043252; GO:0043330; GO:0051630; GO:0089718; GO:0097421
GN020804	GN020804.1	Q9VCA2	27.0	529	528	548	8.75e-56	199	ORCT_DROME	Organic cation transporter protein	Drosophila melanogaster (Fruit fly)	apoptotic process [GO:0006915]	transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]	GO:0006915; GO:0016020; GO:0022857
GN020805	GN020805.1	P17139	62.4	221	685	1759	3.11e-94	323	CO4A1_CAEEL	Collagen alpha-1(IV) chain	Caenorhabditis elegans	embryo development ending in birth or egg hatching [GO:0009792]; extracellular matrix organization [GO:0030198]; muscle organ development [GO:0007517]; nematode larval development [GO:0002119]; positive regulation of axon regeneration [GO:0048680]; positive regulation of protein secretion [GO:0050714]; response to serotonin [GO:1904014]	extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring tensile strength [GO:0030020]	basement membrane [GO:0005604]; collagen type IV trimer [GO:0005587]; extracellular matrix [GO:0031012]	GO:0002119; GO:0005201; GO:0005587; GO:0005604; GO:0007517; GO:0009792; GO:0030020; GO:0030198; GO:0031012; GO:0048680; GO:0050714; GO:1904014
GN020806	GN020806.1	Q8TBB0	38.1	84	106	222	9.06e-13	64.7	THAP6_HUMAN	THAP domain-containing protein 6	Homo sapiens (Human)			microtubule cytoskeleton [GO:0015630]	GO:0015630
GN020809	GN020809.1	Q05940	40.0	470	470	514	5.37e-106	327	VMAT2_HUMAN	Synaptic vesicular amine transporter (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2) (Vesicular monoamine transporter 2)	Homo sapiens (Human)	aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; chemical synaptic transmission [GO:0007268]; histamine secretion by mast cell [GO:0002553]; histamine uptake [GO:0051615]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter transport [GO:0006836]; serotonin secretion by mast cell [GO:0002552]; serotonin uptake [GO:0051610]; somato-dendritic dopamine secretion [GO:0099123]	monoamine transmembrane transporter activity [GO:0008504]; monoamine:proton antiporter activity [GO:0015311]; serotonin:sodium:chloride symporter activity [GO:0005335]	axon [GO:0030424]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; dendrite [GO:0030425]; dopaminergic synapse [GO:0098691]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	GO:0002552; GO:0002553; GO:0005335; GO:0005886; GO:0006836; GO:0007268; GO:0008021; GO:0008504; GO:0015311; GO:0015842; GO:0016020; GO:0030424; GO:0030425; GO:0030667; GO:0030672; GO:0043195; GO:0051610; GO:0051615; GO:0070083; GO:0098691; GO:0098700; GO:0099123; GO:1903427
GN020810	GN020810.1	Q6DE96	49.4	393	743	836	4.39e-99	327	IWS1A_XENLA	Protein IWS1 homolog A (IWS1-like protein A)	Xenopus laevis (African clawed frog)	poly(A)+ mRNA export from nucleus [GO:0016973]		nucleus [GO:0005634]	GO:0005634; GO:0016973
GN020814	GN020814.1	Q6P587	51.0	210	217	221	8.36e-72	220	FAHD1_HUMAN	Oxaloacetate tautomerase FAHD1, mitochondrial (EC 5.3.2.2) (Acylpyruvase FAHD1) (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1) (FAH domain-containing protein 1) (Oxaloacetate decarboxylase) (OAA decarboxylase) (ODx) (EC 4.1.1.112) (YisK-like protein)	Homo sapiens (Human)	oxaloacetate metabolic process [GO:0006107]	acetylpyruvate hydrolase activity [GO:0018773]; acylpyruvate hydrolase activity [GO:0047621]; fumarylpyruvate hydrolase activity [GO:0034545]; oxaloacetate decarboxylase activity [GO:0008948]; oxaloacetate tautomerase activity [GO:0050163]	cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005739; GO:0005759; GO:0005829; GO:0006107; GO:0008948; GO:0018773; GO:0034545; GO:0047621; GO:0050163
GN020818	GN020818.1	Q5PQM9	60.4	293	296	291	8.72e-123	355	KMCP1_RAT	Kidney mitochondrial carrier protein 1 (Solute carrier family 25 member 30)	Rattus norvegicus (Rat)	inorganic anion transport [GO:0015698]	solute:inorganic anion antiporter activity [GO:0005452]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005452; GO:0005739; GO:0005743; GO:0015698
GN020819	GN020819.1	P49870	73.6	91	263	360	2.21e-40	145	HR38_BOMMO	Probable nuclear hormone receptor HR38 (bHR38) (Nuclear receptor subfamily 4 group A member 4)	Bombyx mori (Silk moth)	cellular response to corticotropin-releasing hormone stimulus [GO:0071376]	nuclear glucocorticoid receptor binding [GO:0035259]; nuclear receptor activity [GO:0004879]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	nucleus [GO:0005634]; transcription regulator complex [GO:0005667]	GO:0000978; GO:0004879; GO:0005634; GO:0005667; GO:0008270; GO:0035259; GO:0071376
GN020820	GN020820.1	O46036	80.8	360	490	476	7.86e-209	589	CTBP_DROME	C-terminal-binding protein (CtBP protein) (dCtBP)	Drosophila melanogaster (Fruit fly)	chaeta development [GO:0022416]; chromatin remodeling [GO:0006338]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase I [GO:2001208]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory organ precursor cell fate determination [GO:0016360]; wing disc development [GO:0035220]	DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; transcription coregulator binding [GO:0001221]; transcription corepressor activity [GO:0003714]	ATPase complex [GO:1904949]; ISWI-type complex [GO:0031010]; nucleus [GO:0005634]	GO:0000122; GO:0001221; GO:0003712; GO:0003713; GO:0003714; GO:0005634; GO:0006338; GO:0006357; GO:0016360; GO:0016616; GO:0022416; GO:0031010; GO:0035220; GO:0042802; GO:0042803; GO:0045892; GO:0045944; GO:0051287; GO:0090090; GO:0090263; GO:0140297; GO:1904949; GO:2001208
GN020821	GN020821.1	Q9CZJ2	32.1	639	585	685	4.65e-88	290	HS12B_MOUSE	Heat shock 70 kDa protein 12B	Mus musculus (Mouse)	angiogenesis [GO:0001525]; endothelial cell migration [GO:0043542]			GO:0001525; GO:0043542
GN020822	GN020822.1	Q9VN03	51.1	479	504	763	3.35e-171	504	SUV3_DROME	ATP-dependent RNA helicase SUV3 homolog, mitochondrial (EC 3.6.4.13)	Drosophila melanogaster (Fruit fly)	mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrial RNA processing [GO:0000963]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; RNA helicase activity [GO:0003724]	mitochondrial degradosome [GO:0045025]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0000957; GO:0000963; GO:0000965; GO:0003678; GO:0003724; GO:0005524; GO:0005739; GO:0005759; GO:0016887; GO:0045025
GN020823	GN020823.1	Q5BKC6	51.7	234	405	479	1.96e-76	248	HBAP1_RAT	HSPB1-associated protein 1 (27 kDa heat shock protein-associated protein 1) (Protein associated with small stress protein 1)	Rattus norvegicus (Rat)			cytoplasm [GO:0005737]	GO:0005737
GN020824	GN020824.1	Q3ZBE5	60.1	577	574	586	1.77e-207	593	SLU7_BOVIN	Pre-mRNA-splicing factor SLU7	Bos taurus (Bovine)	cellular response to heat [GO:0034605]; intracellular protein transport [GO:0006886]; mRNA cis splicing, via spliceosome [GO:0045292]	pre-mRNA 3'-splice site binding [GO:0030628]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	GO:0005634; GO:0005681; GO:0005737; GO:0006886; GO:0016607; GO:0030628; GO:0034605; GO:0045292
GN020826	GN020826.1	P04755	40.2	164	219	521	3.82e-33	127	ACH3_DROME	Acetylcholine receptor subunit beta-like 1 (Nicotinic acetylcholine receptor beta 1)	Drosophila melanogaster (Fruit fly)	calcium ion transport [GO:0006816]; monoatomic ion transmembrane transport [GO:0034220]; regulation of membrane potential [GO:0042391]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; neurotransmitter receptor activity [GO:0030594]; transmembrane signaling receptor activity [GO:0004888]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0004888; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0022848; GO:0030594; GO:0034220; GO:0042391; GO:0043005; GO:0045202; GO:0045211
GN020827	GN020827.1	P02717	33.1	357	362	513	1.26e-46	169	ACHD_CHICK	Acetylcholine receptor subunit delta	Gallus gallus (Chicken)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; skeletal muscle contraction [GO:0003009]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0003009; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0015464; GO:0022848; GO:0034220; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500
GN020829	GN020829.1	P02717	33.3	279	285	513	1.09e-38	145	ACHD_CHICK	Acetylcholine receptor subunit delta	Gallus gallus (Chicken)	acetylcholine receptor signaling pathway [GO:0095500]; calcium ion transport [GO:0006816]; membrane depolarization [GO:0051899]; monoatomic ion transmembrane transport [GO:0034220]; skeletal muscle contraction [GO:0003009]; synaptic transmission, cholinergic [GO:0007271]	acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]	acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]	GO:0003009; GO:0005886; GO:0005892; GO:0006816; GO:0007271; GO:0015464; GO:0022848; GO:0034220; GO:0043005; GO:0045202; GO:0045211; GO:0051899; GO:0095500
GN020830	GN020830.1	Q9VIH7	39.4	541	708	587	3.90e-112	353	SKY_DROME	GTPase-activating protein skywalker	Drosophila melanogaster (Fruit fly)	chemical synaptic transmission [GO:0007268]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of synaptic vesicle recycling [GO:1903422]; neuromuscular synaptic transmission [GO:0007274]; neuron projection development [GO:0031175]; synaptic vesicle endosomal processing [GO:0099532]; synaptic vesicle recycling via endosome [GO:0036466]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; endosome membrane [GO:0010008]; neuromuscular junction [GO:0031594]; postsynapse [GO:0098794]; synapse [GO:0045202]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]	GO:0005096; GO:0005737; GO:0007268; GO:0007274; GO:0010008; GO:0030672; GO:0031175; GO:0031594; GO:0036466; GO:0043195; GO:0045202; GO:0046929; GO:0098794; GO:0099532; GO:1903422
GN020831	GN020831.1	Q5PRC1	47.7	193	228	200	7.16e-56	179	LHPL6_DANRE	LHFPL tetraspan subfamily member 6 protein	Danio rerio (Zebrafish) (Brachydanio rerio)			membrane [GO:0016020]	GO:0016020
GN020832	GN020832.1	O73689	47.1	238	457	443	2.32e-64	217	ZIC1_XENLA	Zinc finger protein ZIC 1 (XZic1) (XlZic1) (ODD-paired-like) (Xopl) (ZIC-related protein 1) (ZIC-r1) (Zinc finger protein of the cerebellum 1)	Xenopus laevis (African clawed frog)	central nervous system development [GO:0007417]; dorsal/ventral neural tube patterning [GO:0021904]; neural crest cell differentiation [GO:0014033]; neural crest cell fate commitment [GO:0014034]; neural crest formation [GO:0014029]; neural plate development [GO:0001840]; neurogenesis [GO:0022008]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001840; GO:0003700; GO:0005634; GO:0005737; GO:0006357; GO:0007417; GO:0014029; GO:0014033; GO:0014034; GO:0021904; GO:0022008; GO:0030177; GO:0042307; GO:0045893; GO:0045944
GN020833	GN020833.1	O73689	47.1	238	457	443	2.32e-64	217	ZIC1_XENLA	Zinc finger protein ZIC 1 (XZic1) (XlZic1) (ODD-paired-like) (Xopl) (ZIC-related protein 1) (ZIC-r1) (Zinc finger protein of the cerebellum 1)	Xenopus laevis (African clawed frog)	central nervous system development [GO:0007417]; dorsal/ventral neural tube patterning [GO:0021904]; neural crest cell differentiation [GO:0014033]; neural crest cell fate commitment [GO:0014034]; neural crest formation [GO:0014029]; neural plate development [GO:0001840]; neurogenesis [GO:0022008]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0001840; GO:0003700; GO:0005634; GO:0005737; GO:0006357; GO:0007417; GO:0014029; GO:0014033; GO:0014034; GO:0021904; GO:0022008; GO:0030177; GO:0042307; GO:0045893; GO:0045944
GN020835	GN020835.1	Q6NX31	79.3	721	723	720	0.0	1128	MCM7_XENTR	DNA replication licensing factor mcm7 (EC 3.6.4.12) (CDC47 homolog) (Minichromosome maintenance protein 7)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cell cycle DNA replication [GO:0044786]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair via break-induced replication [GO:0000727]; regulation of DNA-templated DNA replication initiation [GO:0030174]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; chromosome [GO:0005694]; CMG complex [GO:0071162]; MCM complex [GO:0042555]; nucleus [GO:0005634]	GO:0000727; GO:0000785; GO:0003678; GO:0003697; GO:0005524; GO:0005634; GO:0005694; GO:0006270; GO:0006271; GO:0016887; GO:0030174; GO:0042555; GO:0044786; GO:0071162
GN020836	GN020836.1	Q5ZKU1	69.5	259	267	259	8.58e-134	381	DCNL1_CHICK	DCN1-like protein 1 (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1)	Gallus gallus (Chicken)	positive regulation of protein neddylation [GO:2000436]; protein neddylation [GO:0045116]	cullin family protein binding [GO:0097602]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin-like protein binding [GO:0032182]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005634; GO:0005737; GO:0031624; GO:0032182; GO:0045116; GO:0097602; GO:2000436
GN020838	GN020838.1	Q91755	29.7	209	240	913	3.85e-24	103	GRIK2_XENLA	Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)	Xenopus laevis (African clawed frog)	detection of cold stimulus involved in thermoception [GO:0120169]; modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]	extracellularly glutamate-gated ion channel activity [GO:0005234]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	kainate selective glutamate receptor complex [GO:0032983]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]	GO:0004970; GO:0005234; GO:0005886; GO:0015277; GO:0022849; GO:0032983; GO:0035249; GO:0042734; GO:0050804; GO:0098839; GO:0120169; GO:1904315
GN020839	GN020839.1	Q91755	29.8	336	398	913	3.00e-35	141	GRIK2_XENLA	Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)	Xenopus laevis (African clawed frog)	detection of cold stimulus involved in thermoception [GO:0120169]; modulation of chemical synaptic transmission [GO:0050804]; synaptic transmission, glutamatergic [GO:0035249]	extracellularly glutamate-gated ion channel activity [GO:0005234]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]	kainate selective glutamate receptor complex [GO:0032983]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynaptic membrane [GO:0042734]	GO:0004970; GO:0005234; GO:0005886; GO:0015277; GO:0022849; GO:0032983; GO:0035249; GO:0042734; GO:0050804; GO:0098839; GO:0120169; GO:1904315
GN020840	GN020840.1	Q53RE8	53.3	75	218	183	1.28e-21	90.9	ANR39_HUMAN	Ankyrin repeat domain-containing protein 39	Homo sapiens (Human)				
GN020841	GN020841.1	Q08623	52.4	210	246	228	2.12e-71	221	HDHD1_HUMAN	Pseudouridine-5'-phosphatase (EC 3.1.3.96) (Haloacid dehalogenase-like hydrolase domain-containing protein 1) (Haloacid dehalogenase-like hydrolase domain-containing protein 1A) (Protein GS1) (Pseudouridine-5'-monophosphatase) (5'-PsiMPase)	Homo sapiens (Human)		pseudouridine 5'-phosphatase activity [GO:1990738]	cytosol [GO:0005829]	GO:0005829; GO:1990738
GN020843	GN020843.1	O15440	47.2	1406	1415	1437	0.0	1217	MRP5_HUMAN	ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11)	Homo sapiens (Human)	cAMP transport [GO:0070730]; carbohydrate derivative transport [GO:1901264]; cGMP transport [GO:0070731]; export across plasma membrane [GO:0140115]; folate transmembrane transport [GO:0098838]; glutathione transmembrane transport [GO:0034775]; heme transmembrane transport [GO:0035351]; hyaluronan biosynthetic process [GO:0030213]; purine nucleotide transport [GO:0015865]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic metabolic process [GO:0006805]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]	ABC-type 3',5'-cyclic GMP transmembrane transporter activity [GO:1905948]; ABC-type transporter activity [GO:0140359]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; heme transmembrane transporter activity [GO:0015232]; purine nucleotide transmembrane transporter activity [GO:0015216]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; endosome membrane [GO:0010008]; Golgi lumen [GO:0005796]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005524; GO:0005796; GO:0005886; GO:0006805; GO:0006855; GO:0008559; GO:0010008; GO:0015216; GO:0015232; GO:0015562; GO:0015865; GO:0016020; GO:0016323; GO:0016324; GO:0016887; GO:0022857; GO:0030213; GO:0034634; GO:0034775; GO:0035351; GO:0042626; GO:0042908; GO:0042910; GO:0055085; GO:0070730; GO:0070731; GO:0098838; GO:0140115; GO:0140359; GO:0150104; GO:1901264; GO:1905948; GO:1990961
GN020856	GN020856.1	Q49LS8	26.8	370	486	578	3.30e-25	112	XKR6_TETNG	XK-related protein 6	Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)	apoptotic process involved in development [GO:1902742]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]		plasma membrane [GO:0005886]	GO:0005886; GO:0043652; GO:0070782; GO:1902742
GN020858	GN020858.1	Q80V91	59.5	195	928	347	2.25e-69	237	DTX3_MOUSE	E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (mDTX3) (RING-type E3 ubiquitin transferase DTX3)	Mus musculus (Mouse)	Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0007219; GO:0008593; GO:0016567; GO:0061630
GN020859	GN020859.1	Q3UIR3	54.4	182	1081	748	1.95e-53	204	DTX3L_MOUSE	E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L)	Mus musculus (Mouse)	DNA damage checkpoint signaling [GO:0000077]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; endosome to lysosome transport [GO:0008333]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; Notch signaling pathway [GO:0007219]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor catabolic process [GO:2000646]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone H4K91 ubiquitin ligase activity [GO:0141000]; histone ubiquitin ligase activity [GO:0140852]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]; STAT family protein binding [GO:0097677]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000077; GO:0002230; GO:0004842; GO:0004857; GO:0005634; GO:0005654; GO:0005737; GO:0005764; GO:0005765; GO:0005829; GO:0006302; GO:0006511; GO:0007219; GO:0008333; GO:0016567; GO:0019899; GO:0031901; GO:0032991; GO:0042393; GO:0044389; GO:0045893; GO:0051444; GO:0051865; GO:0061630; GO:0070936; GO:0097677; GO:0140768; GO:0140852; GO:0140861; GO:0141000; GO:1900182; GO:1902966; GO:2000646
GN020860	GN020860.1	Q8TDB6	54.9	182	995	740	3.63e-57	214	DTX3L_HUMAN	E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)	Homo sapiens (Human)	DNA damage checkpoint signaling [GO:0000077]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; endosome to lysosome transport [GO:0008333]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; Notch signaling pathway [GO:0007219]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of receptor catabolic process [GO:2000646]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone H4K91 ubiquitin ligase activity [GO:0141000]; histone ubiquitin ligase activity [GO:0140852]; protein ADP-ribosyltransferase-substrate adaptor activity [GO:0140768]; STAT family protein binding [GO:0097677]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000077; GO:0002230; GO:0004842; GO:0004857; GO:0005634; GO:0005654; GO:0005737; GO:0005764; GO:0005765; GO:0005829; GO:0006302; GO:0006511; GO:0007219; GO:0008333; GO:0016567; GO:0019899; GO:0031901; GO:0032092; GO:0032991; GO:0035563; GO:0042393; GO:0044389; GO:0045893; GO:0051444; GO:0051865; GO:0061630; GO:0070936; GO:0097677; GO:0140768; GO:0140852; GO:0140861; GO:0141000; GO:1900182; GO:1902966; GO:2000646
GN020862	GN020862.1	Q2TBT5	53.4	296	299	299	2.75e-107	317	RNH2A_BOVIN	Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A)	Bos taurus (Bovine)	ribonucleotide excision repair [GO:1990516]; RNA catabolic process [GO:0006401]	RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ribonuclease H2 complex [GO:0032299]	GO:0003723; GO:0004523; GO:0005654; GO:0005829; GO:0006401; GO:0032299; GO:1990516
GN020863	GN020863.1	Q460N5	23.8	987	2476	1801	6.78e-71	269	PAR14_HUMAN	Protein mono-ADP-ribosyltransferase PARP14 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) (Poly [ADP-ribose] polymerase 14) (PARP-14)	Homo sapiens (Human)	NAD+ catabolic process [GO:0019677]; negative regulation of gene expression [GO:0010629]; negative regulation of type II interferon-mediated signaling pathway [GO:0060336]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; positive regulation of interleukin-4-mediated signaling pathway [GO:1902216]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein poly-ADP-ribosylation [GO:0070212]	enzyme binding [GO:0019899]; NAD+ binding [GO:0070403]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0003714; GO:0003950; GO:0005634; GO:0005737; GO:0005829; GO:0010629; GO:0016020; GO:0019677; GO:0019899; GO:0042531; GO:0042532; GO:0060336; GO:0070212; GO:0070403; GO:0140807; GO:1902216; GO:1990404
GN020870	GN020870.1	P0DUE1	27.8	291	729	415	1.53e-23	107	STING_MAGGI	Stimulator of interferon genes protein (TIR-STING) (Probable NAD(+) hydrolase) (EC 3.2.2.6)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	activation of innate immune response [GO:0002218]; autophagosome assembly [GO:0000045]; innate immune response [GO:0045087]; positive regulation of macroautophagy [GO:0016239]; positive regulation of type I interferon production [GO:0032481]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; NAD+ nucleosidase activity, cyclic ADP-ribose generating [GO:0061809]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]	GO:0000045; GO:0002218; GO:0005776; GO:0005789; GO:0007165; GO:0016239; GO:0032481; GO:0035438; GO:0045087; GO:0061507; GO:0061709; GO:0061809
GN020871	GN020871.1	O08688	44.9	599	652	640	2.04e-180	529	CAN5_MOUSE	Calpain-5 (EC 3.4.22.-) (New calpain 3) (nCL-3)	Mus musculus (Mouse)	proteolysis [GO:0006508]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; synapse [GO:0045202]	GO:0004198; GO:0005737; GO:0006508; GO:0009986; GO:0045202
GN020872	GN020872.1	O08688	41.4	278	318	640	2.02e-61	209	CAN5_MOUSE	Calpain-5 (EC 3.4.22.-) (New calpain 3) (nCL-3)	Mus musculus (Mouse)	proteolysis [GO:0006508]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; synapse [GO:0045202]	GO:0004198; GO:0005737; GO:0006508; GO:0009986; GO:0045202
GN020873	GN020873.1	Q0IJ33	51.1	360	365	362	4.34e-136	395	TM129_XENTR	E3 ubiquitin-protein ligase TM129 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TM129)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0005783; GO:0005789; GO:0016567; GO:0061630
GN020875	GN020875.1	O95251	40.9	208	328	611	9.36e-34	134	KAT7_HUMAN	Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)	Homo sapiens (Human)	DNA replication-dependent chromatin disassembly [GO:0140889]; internal peptidyl-lysine acetylation [GO:0018393]; natural killer cell differentiation [GO:0001779]; positive regulation of DNA replication [GO:0045740]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; regulation of DNA biosynthetic process [GO:2000278]; regulation of DNA replication [GO:0006275]; regulation of DNA-templated DNA replication initiation [GO:0030174]; regulation of DNA-templated transcription [GO:0006355]; regulation of nucleotide-excision repair [GO:2000819]; regulation of transcription by RNA polymerase II [GO:0006357]; response to actinomycin D [GO:0072716]; response to anisomycin [GO:0072739]; response to dithiothreitol [GO:0072720]; response to hydroxyurea [GO:0072710]; response to sorbitol [GO:0072708]; stress-activated protein kinase signaling cascade [GO:0031098]; T cell differentiation [GO:0030217]; transcription initiation-coupled chromatin remodeling [GO:0045815]	chromatin binding [GO:0003682]; DNA replication origin binding [GO:0003688]; histone acetyltransferase activity [GO:0004402]; histone H3 acetyltransferase activity [GO:0010484]; histone H3K14 acetyltransferase activity [GO:0036408]; histone H3K23 acetyltransferase activity [GO:0043994]; histone H3K4 acetyltransferase activity [GO:0044016]; histone H4 acetyltransferase activity [GO:0010485]; histone H4K12 acetyltransferase activity [GO:0043997]; histone H4K5 acetyltransferase activity [GO:0043995]; histone H4K8 acetyltransferase activity [GO:0043996]; transcription coregulator activity [GO:0003712]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; histone H3-K14 acetyltransferase complex [GO:0036409]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0000123; GO:0000775; GO:0001558; GO:0001779; GO:0003682; GO:0003688; GO:0003712; GO:0004402; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0006275; GO:0006355; GO:0006357; GO:0008270; GO:0010484; GO:0010485; GO:0018393; GO:0030174; GO:0030217; GO:0031098; GO:0032786; GO:0036408; GO:0036409; GO:0043994; GO:0043995; GO:0043996; GO:0043997; GO:0044016; GO:0045648; GO:0045740; GO:0045815; GO:0045944; GO:0051726; GO:0072708; GO:0072710; GO:0072716; GO:0072720; GO:0072739; GO:0090734; GO:0140889; GO:1900182; GO:1902035; GO:2000278; GO:2000819
GN020876	GN020876.1	Q60HF3	30.9	363	701	667	1.65e-38	155	HPS1_MACFA	BLOC-3 complex member HPS1 (Hermansky-Pudlak syndrome 1 protein homolog)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	melanosome assembly [GO:1903232]; vesicle-mediated transport [GO:0016192]	guanyl-nucleotide exchange factor activity [GO:0005085]	BLOC-3 complex [GO:0031085]	GO:0005085; GO:0016192; GO:0031085; GO:1903232
GN020877	GN020877.1	Q4QR06	37.3	150	217	259	8.51e-20	87.8	PCGF1_XENLA	Polycomb group RING finger protein 1	Xenopus laevis (African clawed frog)	chromatin remodeling [GO:0006338]; negative regulation of transcription by RNA polymerase II [GO:0000122]	promoter-specific chromatin binding [GO:1990841]	nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]	GO:0000122; GO:0005634; GO:0006338; GO:0031519; GO:0035102; GO:1990841
GN020878	GN020878.1	Q9BRZ2	26.3	213	656	755	1.81e-12	74.3	TRI56_HUMAN	E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56)	Homo sapiens (Human)	defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340]	RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0003723; GO:0004842; GO:0005654; GO:0005737; GO:0005829; GO:0006513; GO:0008270; GO:0032479; GO:0032728; GO:0034340; GO:0045087; GO:0045089; GO:0051607; GO:0060340; GO:0061630; GO:0070534; GO:1901224
GN020879	GN020879.1	Q90XN9	46.9	260	315	290	1.41e-44	156	HMX3B_ORYLA	Homeobox protein HMX3-B (Homeobox protein H6 family member 3-B) (Homeobox protein Nkx-5.1.2) (OlNkx-5.1.2)	Oryzias latipes (Japanese rice fish) (Japanese killifish)	cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0030154
GN020882	GN020882.1	Q69ZM6	39.5	1334	1299	1316	2.45e-276	822	STK36_MOUSE	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog)	Mus musculus (Mouse)	axoneme assembly [GO:0035082]; brain development [GO:0007420]; cilium assembly [GO:0060271]; epithelial cilium movement involved in extracellular fluid movement [GO:0003351]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; smoothened signaling pathway [GO:0007224]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; transcription corepressor binding [GO:0001222]	axoneme [GO:0005930]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0001222; GO:0003351; GO:0004674; GO:0005524; GO:0005576; GO:0005634; GO:0005737; GO:0005829; GO:0005930; GO:0007224; GO:0007420; GO:0009791; GO:0035082; GO:0045880; GO:0060271; GO:0097542; GO:0106310
GN020883	GN020883.1	Q90XN9	46.9	260	315	290	1.41e-44	156	HMX3B_ORYLA	Homeobox protein HMX3-B (Homeobox protein H6 family member 3-B) (Homeobox protein Nkx-5.1.2) (OlNkx-5.1.2)	Oryzias latipes (Japanese rice fish) (Japanese killifish)	cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0030154
GN020884	GN020884.1	Q5UR46	32.0	203	515	297	6.36e-18	87.8	YR571_MIMIV	Uncharacterized protein R571 (EC 3.1.1.-)	Acanthamoeba polyphaga mimivirus (APMV)	lipid catabolic process [GO:0016042]	hydrolase activity [GO:0016787]	membrane [GO:0016020]	GO:0016020; GO:0016042; GO:0016787
GN020886	GN020886.1	Q54U75	27.9	280	317	369	3.05e-23	101	CRLA_DICDI	Cyclic AMP receptor-like protein A	Dictyostelium discoideum (Social amoeba)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; negative regulation of cell growth [GO:0030308]; signal transduction [GO:0007165]; sporulation resulting in formation of a cellular spore [GO:0030435]	cAMP receptor activity [GO:0001646]; G protein-coupled receptor activity [GO:0004930]	membrane [GO:0016020]	GO:0001646; GO:0004930; GO:0007165; GO:0007189; GO:0016020; GO:0030308; GO:0030435
GN020887	GN020887.1	B9RK42	30.9	262	306	391	6.06e-34	130	GPC1_RICCO	Glycerophosphocholine acyltransferase 1 (GPCAT) (EC 2.3.1.-)	Ricinus communis (Castor bean)	phosphatidylcholine biosynthetic process [GO:0006656]		membrane [GO:0016020]	GO:0006656; GO:0016020
GN020889	GN020889.1	Q86X83	61.3	199	199	199	1.45e-84	251	COMD2_HUMAN	COMM domain-containing protein 2	Homo sapiens (Human)	endocytic recycling [GO:0032456]		cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; protein-containing complex [GO:0032991]	GO:0005737; GO:0005789; GO:0010008; GO:0032456; GO:0032991
GN020890	GN020890.1	Q4R703	23.7	557	743	703	1.35e-16	87.8	CEP63_MACFA	Centrosomal protein of 63 kDa (Cep63)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	centriole replication [GO:0007099]; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535]; DNA damage checkpoint signaling [GO:0000077]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; protein stabilization [GO:0050821]; signal transduction in response to DNA damage [GO:0042770]; spindle assembly [GO:0051225]		centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; spindle pole [GO:0000922]	GO:0000077; GO:0000922; GO:0005813; GO:0005814; GO:0007099; GO:0034451; GO:0042770; GO:0050821; GO:0051225; GO:0098535; GO:1900045
GN020891	GN020891.1	Q7L0X2	35.5	276	775	663	1.27e-33	141	ERIP6_HUMAN	Glutamate-rich protein 6 (Protein FAM194A)	Homo sapiens (Human)			nucleus [GO:0005634]	GO:0005634
GN020893	GN020893.1	Q6Q899	34.5	692	1276	926	1.93e-95	331	RIGI_MOUSE	Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)	Mus musculus (Mouse)	antiviral innate immune response [GO:0140374]; cellular response to exogenous dsRNA [GO:0071360]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mRNA transcription [GO:0009299]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; pattern recognition receptor activity [GO:0038187]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; ruffle membrane [GO:0032587]	GO:0002230; GO:0002735; GO:0002753; GO:0003690; GO:0003724; GO:0003725; GO:0003727; GO:0005524; GO:0005525; GO:0005737; GO:0005829; GO:0005886; GO:0005923; GO:0008270; GO:0009299; GO:0009597; GO:0009615; GO:0010467; GO:0010628; GO:0015629; GO:0016887; GO:0030334; GO:0031625; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0032760; GO:0038187; GO:0039529; GO:0042802; GO:0043330; GO:0045087; GO:0045944; GO:0051607; GO:0060760; GO:0071360; GO:0140374; GO:1990904
GN020894	GN020894.1	Q7L273	52.1	328	417	389	2.65e-76	245	KCTD9_HUMAN	BTB/POZ domain-containing protein KCTD9	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]	cullin family protein binding [GO:0097602]; identical protein binding [GO:0042802]		GO:0016567; GO:0035556; GO:0042802; GO:0051260; GO:0097602
GN020895	GN020895.1	Q2HJ98	63.1	130	130	221	2.53e-57	180	FAHD1_BOVIN	Oxaloacetate tautomerase FAHD1, mitochondrial (EC 5.3.2.2) (Acylpyruvase FAHD1) (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.112)	Bos taurus (Bovine)	oxaloacetate metabolic process [GO:0006107]	acetylpyruvate hydrolase activity [GO:0018773]; acylpyruvate hydrolase activity [GO:0047621]; fumarylpyruvate hydrolase activity [GO:0034545]; oxaloacetate decarboxylase activity [GO:0008948]; oxaloacetate tautomerase activity [GO:0050163]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0005654; GO:0005739; GO:0005829; GO:0006107; GO:0008948; GO:0018773; GO:0034545; GO:0047621; GO:0050163
GN020897	GN020897.1	Q12907	52.6	323	331	356	3.17e-118	348	LMAN2_HUMAN	Vesicular integral-membrane protein VIP36 (Glycoprotein GP36b) (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36)	Homo sapiens (Human)	endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of phagocytosis [GO:0050766]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	carbohydrate binding [GO:0030246]; D-mannose binding [GO:0005537]; heat shock protein binding [GO:0031072]	cell surface [GO:0009986]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	GO:0000139; GO:0005537; GO:0005576; GO:0005789; GO:0005793; GO:0005794; GO:0005886; GO:0006888; GO:0006890; GO:0009986; GO:0030134; GO:0030246; GO:0031072; GO:0033116; GO:0050766; GO:0070062
GN020898	GN020898.1	Q8N7B6	58.5	193	223	248	1.32e-73	226	PACRL_HUMAN	PACRG-like protein	Homo sapiens (Human)				
GN020900	GN020900.1	Q8BJM3	55.3	199	650	775	3.66e-51	192	R3HCL_MOUSE	Coiled-coil domain-containing protein R3HCC1L (Growth inhibition and differentiation-related protein 88 homolog) (R3H and coiled-coil domain-containing protein 1-like)	Mus musculus (Mouse)				
GN020902	GN020902.1	Q6DDK3	32.4	315	406	308	9.95e-39	144	DOXA1_XENLA	Dual oxidase maturation factor 1 (Dual oxidase activator 1)	Xenopus laevis (African clawed frog)	protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]		apical plasma membrane [GO:0016324]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0005789; GO:0015031; GO:0016020; GO:0016324; GO:0072659
GN020906	GN020906.1	Q8IV48	52.7	262	360	349	1.29e-89	276	ERI1_HUMAN	3'-5' exoribonuclease 1 (EC 3.1.13.1) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO)	Homo sapiens (Human)	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; maturation of 5.8S rRNA [GO:0000460]; negative regulation of regulatory ncRNA-mediated heterochromatin formation [GO:0060906]; rRNA 3'-end processing [GO:0031125]	3'-5' exonuclease activity [GO:0008408]; 3'-5'-RNA exonuclease activity [GO:0000175]; exoribonuclease II activity [GO:0008859]; histone pre-mRNA stem-loop binding [GO:0071207]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]	cytoplasm [GO:0005737]; histone pre-mRNA 3'end processing complex [GO:0071204]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0000175; GO:0000460; GO:0000467; GO:0005634; GO:0005730; GO:0005737; GO:0008408; GO:0008859; GO:0019843; GO:0031125; GO:0043022; GO:0060906; GO:0071204; GO:0071207
GN020907	GN020907.1	Q7Z9I2	28.2	277	263	253	1.08e-23	99.4	YCP9_SCHPO	Uncharacterized oxidoreductase C663.09c (EC 1.-.-.-)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	cellular detoxification of aldehyde [GO:0110095]	alcohol dehydrogenase (NAD+) activity [GO:0004022]; oxidoreductase activity [GO:0016491]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004022; GO:0005634; GO:0005829; GO:0016491; GO:0110095
GN020908	GN020908.1	Q8TF76	49.6	335	803	798	4.47e-96	320	HASP_HUMAN	Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase)	Homo sapiens (Human)	intracellular signal transduction [GO:0035556]; mitotic sister chromatid cohesion [GO:0007064]; mitotic spindle assembly checkpoint signaling [GO:0007094]; protein localization to chromosome, centromeric region [GO:0071459]; protein phosphorylation [GO:0006468]	ATP binding [GO:0005524]; histone H3T3 kinase activity [GO:0072354]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]	centrosome [GO:0005813]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0004672; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005813; GO:0005819; GO:0006468; GO:0007064; GO:0007094; GO:0035556; GO:0071459; GO:0072354; GO:0106310
GN020911	GN020911.1	P42325	50.0	182	181	190	5.97e-58	182	NCAH_DROME	Neurocalcin homolog (DrosNCa)	Drosophila melanogaster (Fruit fly)	negative regulation of neuronal signal transduction [GO:1902848]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; regulation of signal transduction [GO:0009966]	calcium ion binding [GO:0005509]		GO:0005509; GO:0009966; GO:0045938; GO:1902848
GN020912	GN020912.1	P77735	39.1	335	360	324	9.65e-62	203	YAJO_ECOLI	1-deoxyxylulose-5-phosphate synthase YajO (EC 1.1.-.-)	Escherichia coli (strain K12)	isoprenoid biosynthetic process via mevalonate [GO:1902767]; thiamine metabolic process [GO:0006772]	oxidoreductase activity [GO:0016491]	cytosol [GO:0005829]	GO:0005829; GO:0006772; GO:0016491; GO:1902767
GN020915	GN020915.1	Q15459	60.2	743	703	793	1.15e-221	642	SF3A1_HUMAN	Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114)	Homo sapiens (Human)	mRNA 3'-splice site recognition [GO:0000389]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal snRNP assembly [GO:0000387]; U2-type prespliceosome assembly [GO:1903241]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U2 snRNP [GO:0005686]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U2-type spliceosomal complex [GO:0005684]	GO:0000387; GO:0000389; GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005684; GO:0005686; GO:0006397; GO:0016607; GO:0045292; GO:0071004; GO:0071005; GO:0071006; GO:0071011; GO:0071013; GO:1903241
GN020917	GN020917.1	Q16281	48.9	466	955	694	3.48e-144	448	CNGA3_HUMAN	Cyclic nucleotide-gated channel alpha-3 (CNG channel alpha-3) (CNG-3) (CNG3) (Cone photoreceptor cGMP-gated channel subunit alpha-3)	Homo sapiens (Human)	inorganic cation import across plasma membrane [GO:0098659]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; response to cAMP [GO:0051591]; response to magnesium ion [GO:0032026]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; visual perception [GO:0007601]	cadherin binding [GO:0045296]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; myosin binding [GO:0017022]	axon initial segment [GO:0043194]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]	GO:0005222; GO:0005223; GO:0005886; GO:0006812; GO:0007165; GO:0007601; GO:0015276; GO:0017022; GO:0017071; GO:0030425; GO:0030553; GO:0032026; GO:0043194; GO:0043204; GO:0045296; GO:0051591; GO:0060041; GO:0097386; GO:0098655; GO:0098659; GO:1902495
GN020918	GN020918.1	Q13115	44.5	292	375	394	9.45e-79	250	DUS4_HUMAN	Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)	Homo sapiens (Human)	dephosphorylation [GO:0016311]; endoderm formation [GO:0001706]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]	MAP kinase serine/threonine phosphatase activity [GO:1990439]; MAP kinase tyrosine/serine/threonine phosphatase activity [GO:0017017]; phosphatase activity [GO:0016791]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/threonine phosphatase activity [GO:0008330]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001706; GO:0004722; GO:0004725; GO:0005634; GO:0005654; GO:0008330; GO:0016311; GO:0016791; GO:0017017; GO:0070373; GO:1990439
GN020920	GN020920.1	Q9VB74	80.5	113	450	463	1.61e-47	172	NKAP_DROME	NF-kappa-B-activating protein (NFKB activating protein) (dNKAP)	Drosophila melanogaster (Fruit fly)	mRNA splicing, via spliceosome [GO:0000398]	chromatin binding [GO:0003682]	catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]	GO:0000398; GO:0003682; GO:0005634; GO:0071013
GN020921	GN020921.1	F1RAX4	25.6	531	667	670	1.02e-28	125	STRA6_DANRE	Receptor for retinol uptake stra6 (Stimulated by retinoic acid gene 6 protein homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	chordate embryonic development [GO:0043009]; retinol transport [GO:0034633]; vitamin A import into cell [GO:0071939]	calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; retinol transmembrane transporter activity [GO:0034632]; signaling receptor activity [GO:0038023]	plasma membrane [GO:0005886]	GO:0005516; GO:0005886; GO:0034632; GO:0034633; GO:0038023; GO:0042802; GO:0043009; GO:0060090; GO:0071939
GN020922	GN020922.1	A8MT70	30.9	350	976	800	9.40e-21	102	ZBBX_HUMAN	Zinc finger B-box domain-containing protein 1	Homo sapiens (Human)				
GN020923	GN020923.1	Q5ZLT0	71.4	1080	1087	1087	0.0	1513	XPO7_CHICK	Exportin-7	Gallus gallus (Chicken)	protein export from nucleus [GO:0006611]	nuclear export signal receptor activity [GO:0005049]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]	GO:0005049; GO:0005643; GO:0005737; GO:0006611; GO:0031267
GN020924	GN020924.1	P42168	80.9	320	411	341	9.50e-190	532	KC1A_CAEEL	Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1)	Caenorhabditis elegans	negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, regulating spindle positioning [GO:0060069]	ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0016055; GO:0032436; GO:0060069; GO:0090090; GO:0106310
GN020930	GN020930.1	Q96J01	64.7	272	275	351	5.60e-125	362	THOC3_HUMAN	THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45)	Homo sapiens (Human)	mRNA export from nucleus [GO:0006406]		nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; THO complex part of transcription export complex [GO:0000445]; transcription export complex [GO:0000346]	GO:0000346; GO:0000445; GO:0005654; GO:0006406; GO:0016607
GN020931	GN020931.1	Q22505	29.1	519	815	679	1.74e-54	203	IMMT1_CAEEL	MICOS complex subunit MIC60-1 (Inner mitochondrial membrane protein 1) (Mitofilin homolog 1)	Caenorhabditis elegans	cristae formation [GO:0042407]; mitochondrion organization [GO:0007005]; response to reactive oxygen species [GO:0000302]		cytoplasm [GO:0005737]; MICOS complex [GO:0061617]; mitochondrial inner membrane [GO:0005743]; proton-transporting ATP synthase complex [GO:0045259]	GO:0000302; GO:0005737; GO:0005743; GO:0007005; GO:0042407; GO:0045259; GO:0061617
GN020932	GN020932.1	Q6P2X9	22.2	481	494	473	2.36e-33	135	MOT12_XENTR	Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0046449
GN020933	GN020933.1	Q6PCJ1	37.9	715	707	1232	3.70e-129	415	DCTN1_XENLA	Dynactin subunit 1	Xenopus laevis (African clawed frog)	cytoplasmic microtubule organization [GO:0031122]; establishment of mitotic spindle orientation [GO:0000132]; nuclear migration [GO:0007097]; positive regulation of intracellular protein transport [GO:0090316]; regulation of mitotic spindle organization [GO:0060236]	microtubule binding [GO:0008017]	axon [GO:0030424]; cell cortex [GO:0005938]; cell cortex region [GO:0099738]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule plus-end [GO:0035371]; spindle pole [GO:0000922]	GO:0000132; GO:0000776; GO:0000922; GO:0005737; GO:0005813; GO:0005814; GO:0005874; GO:0005875; GO:0005938; GO:0007097; GO:0008017; GO:0030424; GO:0031122; GO:0035371; GO:0060236; GO:0090316; GO:0099738
GN020934	GN020934.1	A1A4N1	29.1	429	474	474	6.27e-52	185	S29A3_BOVIN	Equilibrative nucleoside transporter 3 (Solute carrier family 29 member 3)	Bos taurus (Bovine)	adenosine transport [GO:0032238]; cytidine transport [GO:0015861]; guanine transmembrane transport [GO:1903716]; inosine transport [GO:0035340]; nucleobase transport [GO:0015851]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]; purine nucleobase transmembrane transport [GO:1904823]; pyrimidine nucleobase transmembrane transport [GO:1904082]; uracil transmembrane transport [GO:1903791]; uridine transmembrane transport [GO:0015862]	cytidine transmembrane transporter activity [GO:0015212]; guanine transmembrane transporter activity [GO:0015208]; monoamine transmembrane transporter activity [GO:0008504]; neurotransmitter transmembrane transporter activity [GO:0005326]; nucleobase transmembrane transporter activity [GO:0015205]; nucleoside transmembrane transporter activity [GO:0005337]; transmembrane transporter activity [GO:0022857]; uracil transmembrane transporter activity [GO:0015210]; urate transmembrane transporter activity [GO:0015143]; uridine transmembrane transporter activity [GO:0015213]	Golgi apparatus [GO:0005794]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrial membrane [GO:0031966]; plasma membrane [GO:0005886]	GO:0005326; GO:0005337; GO:0005765; GO:0005794; GO:0005886; GO:0008504; GO:0015143; GO:0015205; GO:0015208; GO:0015210; GO:0015212; GO:0015213; GO:0015851; GO:0015858; GO:0015861; GO:0015862; GO:0022857; GO:0031902; GO:0031966; GO:0032238; GO:0035340; GO:1901642; GO:1903716; GO:1903791; GO:1904082; GO:1904823
GN020937	GN020937.1	Q8IXQ6	24.0	417	768	854	6.89e-11	69.7	PARP9_HUMAN	Protein mono-ADP-ribosyltransferase PARP9 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein) (Poly [ADP-ribose] polymerase 9) (PARP-9)	Homo sapiens (Human)	cell migration [GO:0016477]; DNA damage checkpoint signaling [GO:0000077]; double-strand break repair [GO:0006302]; negative regulation of catalytic activity [GO:0043086]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nicotinate metabolic process [GO:1901847]; positive regulation of chromatin binding [GO:0035563]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of type II interferon-mediated signaling pathway [GO:0060335]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; post-transcriptional regulation of gene expression [GO:0010608]; regulation of response to type II interferon [GO:0060330]; viral protein processing [GO:0019082]	ADP-D-ribose binding [GO:0072570]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity [GO:0140802]; STAT family protein binding [GO:0097677]; transcription corepressor activity [GO:0003714]; ubiquitin-like protein ligase binding [GO:0044389]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of DNA damage [GO:0090734]	GO:0000077; GO:0000122; GO:0002230; GO:0003714; GO:0003950; GO:0004857; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0010608; GO:0010629; GO:0016020; GO:0016477; GO:0019082; GO:0019899; GO:0032991; GO:0035563; GO:0042393; GO:0042531; GO:0043086; GO:0044389; GO:0045893; GO:0060330; GO:0060335; GO:0072570; GO:0090734; GO:0097677; GO:0140802; GO:1900182; GO:1901847
GN020938	GN020938.1	Q8VHT6	48.3	362	368	369	3.27e-118	350	AS3MT_RAT	Arsenite methyltransferase (EC 2.1.1.137) (Methylarsonite methyltransferase) (S-adenosyl-L-methionine:arsenic(III) methyltransferase)	Rattus norvegicus (Rat)	arsonoacetate metabolic process [GO:0018872]; methylation [GO:0032259]; response to arsenic-containing substance [GO:0046685]; toxin metabolic process [GO:0009404]	arsenite methyltransferase activity [GO:0030791]; protein methyltransferase activity [GO:0008276]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	cytosol [GO:0005829]	GO:0005829; GO:0008276; GO:0008757; GO:0009404; GO:0018872; GO:0030791; GO:0032259; GO:0046685
GN020939	GN020939.1	Q9UGP5	47.0	549	541	575	1.23e-162	477	DPOLL_HUMAN	DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa)	Homo sapiens (Human)	base-excision repair, gap-filling [GO:0006287]; DNA biosynthetic process [GO:0071897]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; nucleotide-excision repair [GO:0006289]; somatic hypermutation of immunoglobulin genes [GO:0016446]	5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; DNA binding [GO:0003677]; DNA polymerase activity [GO:0034061]; DNA-directed DNA polymerase activity [GO:0003887]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000724; GO:0003677; GO:0003887; GO:0005634; GO:0005654; GO:0005694; GO:0006260; GO:0006287; GO:0006289; GO:0006303; GO:0016446; GO:0034061; GO:0035861; GO:0051575; GO:0071897
GN020940	GN020940.1	A0JNK3	48.3	319	352	458	1.60e-89	279	HTRA2_BOVIN	Serine protease HTRA2, mitochondrial (EC 3.4.21.108)	Bos taurus (Bovine)	cellular response to oxidative stress [GO:0034599]; intrinsic apoptotic signaling pathway [GO:0097193]; mitochondrion organization [GO:0007005]; positive regulation of apoptotic process [GO:0043065]; programmed cell death [GO:0012501]; proteolysis [GO:0006508]; regulation of autophagy of mitochondrion [GO:1903146]	serine-type endopeptidase activity [GO:0004252]	mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]	GO:0004252; GO:0005739; GO:0005758; GO:0006508; GO:0007005; GO:0012501; GO:0031966; GO:0032991; GO:0034599; GO:0043065; GO:0097193; GO:1903146
GN020941	GN020941.1	Q9NQZ5	42.5	259	375	370	1.24e-69	226	STAR7_HUMAN	StAR-related lipid transfer protein 7, mitochondrial (STARD7, mitochondrial) (Gestational trophoblastic tumor protein 1) (START domain-containing protein 7) (StARD7) (StarD7-I) [Cleaved into: StAR-related lipid transfer protein 7, mature (STARD7, mature) (StarD7-II)]	Homo sapiens (Human)	intermembrane phospholipid transfer [GO:0120010]; mitochondrial membrane organization [GO:0007006]; phosphatidylcholine biosynthetic process [GO:0006656]; regulation of cellular respiration [GO:0043457]; ubiquinone biosynthetic process [GO:0006744]	lipid binding [GO:0008289]; lipid transfer activity [GO:0120013]; phosphatidylcholine transfer activity [GO:0120019]	cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0005739; GO:0005741; GO:0005758; GO:0005829; GO:0006656; GO:0006744; GO:0007006; GO:0008289; GO:0043457; GO:0120010; GO:0120013; GO:0120019
GN020943	GN020943.1	P02637	40.3	176	178	176	1.45e-39	135	SCP_MIZYE	Sarcoplasmic calcium-binding protein (SCP)	Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis)		calcium ion binding [GO:0005509]		GO:0005509
GN020944	GN020944.1	E1BP36	49.1	114	117	1030	1.23e-27	108	MMS19_BOVIN	MMS19 nucleotide excision repair protein homolog (MMS19-like protein)	Bos taurus (Bovine)	protein maturation [GO:0051604]	enzyme binding [GO:0019899]; nuclear estrogen receptor binding [GO:0030331]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; cytosolic [4Fe-4S] assembly targeting complex [GO:0097361]; MMXD complex [GO:0071817]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0019899; GO:0030331; GO:0051604; GO:0071817; GO:0097361
GN020945	GN020945.1	Q6PGH0	74.6	122	121	234	4.89e-60	187	UBTD2_MOUSE	Ubiquitin domain-containing protein 2	Mus musculus (Mouse)			cytoplasm [GO:0005737]	GO:0005737
GN020946	GN020946.1	Q8SWR3	29.4	326	403	435	2.06e-33	132	SPR_DROME	Sex peptide receptor	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of egg-laying behavior [GO:0046662]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007186; GO:0008528; GO:0045434; GO:0046662
GN020948	GN020948.1	Q9H871	56.1	392	391	391	3.09e-157	451	RMD5A_HUMAN	E3 ubiquitin-protein transferase RMND5A (EC 2.3.2.27) (P44CTLH) (Protein RMD5 homolog A)	Homo sapiens (Human)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]	ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GID complex [GO:0034657]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0034657; GO:0043161; GO:0061630
GN020949	GN020949.1	Q9R0D8	42.7	337	331	334	1.61e-84	261	WDR54_MOUSE	WD repeat-containing protein 54	Mus musculus (Mouse)	fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; negative regulation of receptor internalization [GO:0002091]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of MAPK cascade [GO:0043408]; single fertilization [GO:0007338]	protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; motile cilium [GO:0031514]; plasma membrane [GO:0005886]; vesicle [GO:0031982]	GO:0002091; GO:0005737; GO:0005886; GO:0007338; GO:0007342; GO:0031514; GO:0031982; GO:0042058; GO:0042803; GO:0043408
GN020951	GN020951.1	Q0MW30	49.1	55	501	546	4.07e-11	68.9	NEU1B_MOUSE	E3 ubiquitin-protein ligase NEURL1B (EC 2.3.2.27) (Neuralized-2) (NEUR2) (Neuralized-like protein 1B) (Neuralized-like protein 2) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL1B)	Mus musculus (Mouse)	protein ubiquitination [GO:0016567]; ubiquitin-dependent endocytosis [GO:0070086]	ubiquitin protein ligase activity [GO:0061630]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; early endosome [GO:0005769]	GO:0005769; GO:0005829; GO:0015629; GO:0016567; GO:0061630; GO:0070086
GN020954	GN020954.1	O43301	28.9	575	519	675	9.32e-70	239	HS12A_HUMAN	Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)	Homo sapiens (Human)			cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0070062
GN020955	GN020955.1	Q66IL0	52.6	382	403	394	9.67e-138	402	CHID1_XENTR	Chitinase domain-containing protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	carbohydrate metabolic process [GO:0005975]	chitin binding [GO:0008061]; oligosaccharide binding [GO:0070492]	endomembrane system [GO:0012505]; extracellular region [GO:0005576]; lysosome [GO:0005764]	GO:0005576; GO:0005764; GO:0005975; GO:0008061; GO:0012505; GO:0070492
GN020956	GN020956.1	Q5R4M8	58.6	730	805	795	5.75e-281	797	P5CS_PONAB	Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	glutamate metabolic process [GO:0006536]; L-citrulline biosynthetic process [GO:0019240]; L-glutamate catabolic process [GO:0006538]; L-glutamine catabolic process [GO:0006543]; L-ornithine biosynthetic process [GO:0006592]; L-proline biosynthetic process [GO:0055129]	ATP binding [GO:0005524]; delta1-pyrroline-5-carboxylate synthetase activity [GO:0017084]; glutamate 5-kinase activity [GO:0004349]; glutamate-5-semialdehyde dehydrogenase activity [GO:0004350]; identical protein binding [GO:0042802]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0004349; GO:0004350; GO:0005524; GO:0005739; GO:0005759; GO:0006536; GO:0006538; GO:0006543; GO:0006592; GO:0017084; GO:0019240; GO:0042802; GO:0055129
GN020957	GN020957.1	Q11011	54.6	489	661	920	7.15e-180	538	PSA_MOUSE	Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S)	Mus musculus (Mouse)	cellular response to hypoxia [GO:0071456]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]	alanyl aminopeptidase activity [GO:0016285]; aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]	GO:0004177; GO:0005576; GO:0005634; GO:0005829; GO:0006508; GO:0008270; GO:0016285; GO:0043171; GO:0070006; GO:0071456
GN020958	GN020958.1	Q86UB2	52.6	333	668	503	1.31e-111	348	BIVM_HUMAN	Basic immunoglobulin-like variable motif-containing protein	Homo sapiens (Human)		DNA endonuclease activity [GO:0004520]; single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003697; GO:0004520; GO:0005576; GO:0005634; GO:0005654; GO:0005737
GN020961	GN020961.1	P78345	34.4	122	401	283	5.53e-15	78.2	RPP38_HUMAN	Ribonuclease P protein subunit p38 (RNaseP protein p38)	Homo sapiens (Human)	RNA processing [GO:0006396]; tRNA 5'-leader removal [GO:0001682]	ribonuclease P RNA binding [GO:0033204]	multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]	GO:0000172; GO:0001682; GO:0005634; GO:0005654; GO:0005655; GO:0005730; GO:0006396; GO:0030681; GO:0033204
GN020962	GN020962.1	Q5HZP1	41.1	309	303	306	3.08e-67	215	RNH2B_XENLA	Ribonuclease H2 subunit B (RNase H2 subunit B) (Ribonuclease HI subunit B)	Xenopus laevis (African clawed frog)	RNA catabolic process [GO:0006401]		nucleoplasm [GO:0005654]; ribonuclease H2 complex [GO:0032299]	GO:0005654; GO:0006401; GO:0032299
GN020963	GN020963.1	Q5ZK33	35.9	694	792	752	1.35e-93	312	LETM1_CHICK	Mitochondrial proton/calcium exchanger protein (Electroneutral mitochondrial K(+)/H(+)exchanger) (KHE) (Leucine zipper-EF-hand-containing transmembrane protein 1)	Gallus gallus (Chicken)	calcium export from the mitochondrion [GO:0099093]; calcium ion transport [GO:0006816]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrion organization [GO:0007005]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260]	calcium ion binding [GO:0005509]; calcium:proton antiporter activity [GO:0015369]; potassium:proton antiporter activity [GO:0015386]; ribosome binding [GO:0043022]	mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005509; GO:0005739; GO:0005743; GO:0006816; GO:0006851; GO:0007005; GO:0007007; GO:0015369; GO:0015386; GO:0034214; GO:0043022; GO:0051260; GO:0051560; GO:0099093
GN020964	GN020964.1	Q8CHI9	42.0	312	341	561	1.19e-85	271	CHSTF_RAT	Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST)	Rattus norvegicus (Rat)	hexose biosynthetic process [GO:0019319]	3'-phosphoadenosine 5'-phosphosulfate binding [GO:0050656]; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity [GO:0050659]	Golgi membrane [GO:0000139]	GO:0000139; GO:0019319; GO:0050656; GO:0050659
GN020965	GN020965.1	Q8BG30	46.2	543	549	530	3.97e-114	352	NELFA_MOUSE	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 homolog) (mWHSC2)	Mus musculus (Mouse)	negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of protein modification process [GO:0031401]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription pausing by RNA polymerase II [GO:0160239]	chromatin binding [GO:0003682]; molecular adaptor activity [GO:0060090]; RNA polymerase inhibitor activity [GO:0140870]	cytosol [GO:0005829]; NELF complex [GO:0032021]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003682; GO:0005634; GO:0005654; GO:0005829; GO:0016604; GO:0031401; GO:0032021; GO:0034244; GO:0045944; GO:0060090; GO:0140870; GO:0160239
GN020966	GN020966.1	Q503Y7	85.7	126	127	128	1.40e-57	177	PIN4_DANRE	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Rotamase Pin4)	Danio rerio (Zebrafish) (Brachydanio rerio)	rRNA processing [GO:0006364]	DNA binding [GO:0003677]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0003677; GO:0003755; GO:0005634; GO:0005730; GO:0005737; GO:0005819; GO:0006364
GN020968	GN020968.1	Q6NSW5	45.1	344	355	357	1.20e-101	306	DE10B_HUMAN	Putative DENN domain-containing protein 10 B (DENND10 pseudogene 1) (Putative protein FAM45B)	Homo sapiens (Human)	protein transport [GO:0015031]; regulation of early endosome to late endosome transport [GO:2000641]	guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]	late endosome [GO:0005770]	GO:0005085; GO:0005770; GO:0015031; GO:0031267; GO:2000641
GN020970	GN020970.1	B8A4F0	41.7	391	391	387	2.06e-89	278	ZD16A_DANRE	Palmitoyltransferase ZDHHC16A (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 16A) (DHHC-16A)	Danio rerio (Zebrafish) (Brachydanio rerio)	commitment of multipotent stem cells to neuronal lineage in forebrain [GO:0021898]; DNA damage response [GO:0006974]; eye development [GO:0001654]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart development [GO:0007507]; protein palmitoylation [GO:0018345]; telencephalon development [GO:0021537]	palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	GO:0001654; GO:0005789; GO:0005794; GO:0006974; GO:0007507; GO:0008543; GO:0016409; GO:0018345; GO:0019706; GO:0021537; GO:0021898
GN020971	GN020971.1	Q9H015	32.7	416	517	551	2.59e-60	211	S22A4_HUMAN	Solute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (ETTh) (Organic cation/carnitine transporter 1) (OCTN1)	Homo sapiens (Human)	acetylcholine uptake [GO:0051630]; amine transport [GO:0015837]; amino acid import across plasma membrane [GO:0089718]; carnitine transport [GO:0015879]; lactation [GO:0007595]; liver regeneration [GO:0097421]; quaternary ammonium group transport [GO:0015697]; response to exogenous dsRNA [GO:0043330]; response to lipopolysaccharide [GO:0032496]; response to vitamin D [GO:0033280]; sodium-independent organic anion transport [GO:0043252]; sulfur amino acid transport [GO:0000101]; xenobiotic transport [GO:0042908]	acetylcholine transmembrane transporter activity [GO:0005277]; amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; secondary active transmembrane transporter activity [GO:0015291]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	GO:0000101; GO:0005277; GO:0005524; GO:0005739; GO:0005886; GO:0007595; GO:0009925; GO:0015171; GO:0015199; GO:0015226; GO:0015291; GO:0015651; GO:0015697; GO:0015837; GO:0015879; GO:0016324; GO:0030165; GO:0031966; GO:0032496; GO:0033280; GO:0042908; GO:0043025; GO:0043252; GO:0043330; GO:0051630; GO:0089718; GO:0097421
GN020973	GN020973.1	O88545	72.1	308	312	324	4.30e-161	454	CSN6_MOUSE	COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6)	Mus musculus (Mouse)	protein deneddylation [GO:0000338]	metallopeptidase activity [GO:0008237]	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000338; GO:0005634; GO:0005654; GO:0005737; GO:0008180; GO:0008237
GN020974	GN020974.1	Q17QQ4	47.6	185	247	264	1.33e-48	164	TAF9_BOVIN	Transcription initiation factor TFIID subunit 9	Bos taurus (Bovine)	box C/D snoRNP assembly [GO:0000492]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; protein stabilization [GO:0050821]; response to interleukin-1 [GO:0070555]; RNA polymerase II preinitiation complex assembly [GO:0051123]	ATPase binding [GO:0051117]; C2H2 zinc finger domain binding [GO:0070742]; DNA-binding transcription factor binding [GO:0140297]; histone acetyltransferase activity [GO:0004402]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]	MLL1 complex [GO:0071339]; pre-snoRNP complex [GO:0070761]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]	GO:0000124; GO:0000492; GO:0000976; GO:0002039; GO:0003713; GO:0004402; GO:0005669; GO:0032435; GO:0033276; GO:0042789; GO:0043066; GO:0046982; GO:0050821; GO:0051117; GO:0051123; GO:0060261; GO:0060760; GO:0070555; GO:0070742; GO:0070761; GO:0071339; GO:0140297
GN020975	GN020975.1	B3EWZ3	45.2	104	259	1675	8.78e-20	92.0	CADN_ACRMI	Coadhesin	Acropora millepora (Staghorn coral) (Heteropora millepora)			membrane [GO:0016020]	GO:0016020
GN020976	GN020976.1	Q9DB52	33.5	245	344	284	2.35e-17	84.3	PBIR1_MOUSE	P2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1)	Mus musculus (Mouse)	mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of cell growth [GO:0030307]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]	protein phosphatase 2A binding [GO:0051721]; protein phosphatase inhibitor activity [GO:0004864]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]	cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004864; GO:0004865; GO:0005634; GO:0005654; GO:0005737; GO:0016604; GO:0030307; GO:0032436; GO:0044818; GO:0051721
GN020977	GN020977.1	Q8K2J9	24.0	304	362	539	2.26e-19	92.8	BTBD6_MOUSE	BTB/POZ domain-containing protein 6	Mus musculus (Mouse)	neurogenesis [GO:0022008]		cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005737; GO:0005829; GO:0022008
GN020979	GN020979.1	Q9R141	28.3	534	534	553	2.07e-53	192	S22A4_RAT	Solute carrier family 22 member 4 (Organic cation/carnitine transporter 1) (Octn1)	Rattus norvegicus (Rat)	acetylcholine uptake [GO:0051630]; amino acid import across plasma membrane [GO:0089718]; carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879]; lactation [GO:0007595]; liver regeneration [GO:0097421]; quaternary ammonium group transport [GO:0015697]; response to exogenous dsRNA [GO:0043330]; response to lipopolysaccharide [GO:0032496]; response to vitamin D [GO:0033280]; sodium-independent organic anion transport [GO:0043252]; sulfur amino acid transport [GO:0000101]; triglyceride metabolic process [GO:0006641]	acetylcholine transmembrane transporter activity [GO:0005277]; amino acid transmembrane transporter activity [GO:0015171]; amino-acid betaine transmembrane transporter activity [GO:0015199]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]	GO:0000101; GO:0005277; GO:0005524; GO:0005739; GO:0006641; GO:0007595; GO:0009437; GO:0009925; GO:0015171; GO:0015199; GO:0015226; GO:0015651; GO:0015697; GO:0015879; GO:0016324; GO:0030165; GO:0031966; GO:0032496; GO:0033280; GO:0043025; GO:0043252; GO:0043330; GO:0051630; GO:0089718; GO:0097421
GN020980	GN020980.1	Q58PK4	25.4	398	454	412	4.13e-20	95.5	ILE2_BOMOR	Peptidylaminoacyl-L/D-isomerase (EC 5.1.1.21) (Frog skin isomerase)	Bombina orientalis (Oriental fire-bellied toad)				
GN020981	GN020981.1	A2VEC9	26.0	1590	1300	5150	2.45e-112	394	SSPO_HUMAN	SCO-spondin (SCO-spondin pseudogene)	Homo sapiens (Human)		extracellular matrix structural constituent [GO:0005201]; peptidase inhibitor activity [GO:0030414]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]	GO:0005201; GO:0005576; GO:0030414; GO:0031012
GN020982	GN020982.1	P49354	67.0	309	335	379	2.93e-80	252	FNTA_HUMAN	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)	Homo sapiens (Human)	CAAX-box protein maturation [GO:0080120]; peptide pheromone maturation [GO:0007323]; positive regulation of Rac protein signal transduction [GO:0035022]; protein farnesylation [GO:0018343]; protein geranylgeranylation [GO:0018344]; regulation of microtubule-based movement [GO:0060632]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; transforming growth factor beta receptor signaling pathway [GO:0007179]	acetyltransferase activator activity [GO:0010698]; alpha-tubulin binding [GO:0043014]; CAAX-protein geranylgeranyltransferase activity [GO:0004662]; enzyme binding [GO:0019899]; microtubule binding [GO:0008017]; molecular adaptor activity [GO:0060090]; protein farnesyltransferase activity [GO:0004660]; protein geranylgeranyltransferase activity [GO:0004661]; Rab geranylgeranyltransferase activity [GO:0004663]; receptor tyrosine kinase binding [GO:0030971]	CAAX-protein geranylgeranyltransferase complex [GO:0005953]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; protein farnesyltransferase complex [GO:0005965]	GO:0004660; GO:0004661; GO:0004662; GO:0004663; GO:0005737; GO:0005829; GO:0005875; GO:0005886; GO:0005953; GO:0005965; GO:0007179; GO:0007323; GO:0008017; GO:0010698; GO:0018343; GO:0018344; GO:0019899; GO:0030971; GO:0035022; GO:0043014; GO:0060090; GO:0060632; GO:0071340; GO:0080120
GN020983	GN020983.1	Q3B752	52.7	207	209	212	2.61e-76	231	KTHY_DANRE	Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)	Danio rerio (Zebrafish) (Brachydanio rerio)	central nervous system neuron development [GO:0021954]; DNA repair [GO:0006281]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227]	ATP binding [GO:0005524]; dTMP kinase activity [GO:0004798]		GO:0004798; GO:0005524; GO:0006227; GO:0006233; GO:0006235; GO:0006281; GO:0021954
GN020984	GN020984.1	Q9Y6E0	75.6	307	736	443	2.44e-153	456	STK24_HUMAN	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)]	Homo sapiens (Human)	cellular response to oxidative stress [GO:0034599]; cellular response to starvation [GO:0009267]; execution phase of apoptosis [GO:0097194]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of cell migration [GO:0030336]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon regeneration [GO:0048679]; signal transduction [GO:0007165]	ATP binding [GO:0005524]; cadherin binding [GO:0045296]; protein kinase activity [GO:0004672]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005794; GO:0005829; GO:0006468; GO:0007165; GO:0008631; GO:0009267; GO:0016020; GO:0030336; GO:0034599; GO:0035556; GO:0045296; GO:0046777; GO:0048679; GO:0070062; GO:0090443; GO:0097194; GO:0106310
GN020985	GN020985.1	Q9VMW8	54.2	203	229	252	9.73e-66	206	MPU1_DROME	Mannose-P-dolichol utilization defect 1 protein homolog	Drosophila melanogaster (Fruit fly)	oligosaccharide biosynthetic process [GO:0009312]		membrane [GO:0016020]	GO:0009312; GO:0016020
GN020986	GN020986.1	P81134	32.8	351	358	351	4.62e-59	197	RENR_BOVIN	Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor extracellular fragment; Renin receptor cytoplasmic fragment]	Bos taurus (Bovine)	lysosomal lumen acidification [GO:0007042]; pH reduction [GO:0045851]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway [GO:0030177]; proton transmembrane transport [GO:1902600]	signaling receptor activity [GO:0038023]	autophagosome membrane [GO:0000421]; axon [GO:0030424]; clathrin-coated vesicle membrane [GO:0030665]; dendritic spine membrane [GO:0032591]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; lysosomal membrane [GO:0005765]; synaptic vesicle membrane [GO:0030672]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]	GO:0000220; GO:0000421; GO:0005765; GO:0005789; GO:0007042; GO:0009897; GO:0010008; GO:0030177; GO:0030424; GO:0030665; GO:0030672; GO:0032591; GO:0038023; GO:0045851; GO:0090263; GO:1902600
GN020992	GN020992.1	Q7M753	65.5	304	346	456	2.86e-144	418	PANK2_MOUSE	Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2)	Mus musculus (Mouse)	aerobic respiration [GO:0009060]; angiogenesis [GO:0001525]; coenzyme A biosynthetic process [GO:0015937]; mitochondrion organization [GO:0007005]; pantothenate metabolic process [GO:0015939]; regulation of fatty acid metabolic process [GO:0019217]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of triglyceride metabolic process [GO:0090207]; spermatid development [GO:0007286]	ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0001525; GO:0004594; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005758; GO:0005829; GO:0007005; GO:0007286; GO:0009060; GO:0015937; GO:0015939; GO:0019217; GO:0051881; GO:0090207
GN020993	GN020993.1	P46023	36.1	330	477	1115	9.31e-59	212	GR101_LYMST	G protein-coupled receptor GRL101	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; hormone-mediated signaling pathway [GO:0009755]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007189; GO:0008528; GO:0009755
GN020994	GN020994.1	P46023	39.0	231	285	1115	1.02e-46	171	GR101_LYMST	G protein-coupled receptor GRL101	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; hormone-mediated signaling pathway [GO:0009755]	G protein-coupled peptide receptor activity [GO:0008528]	plasma membrane [GO:0005886]	GO:0005886; GO:0007189; GO:0008528; GO:0009755
GN020995	GN020995.1	Q8CDT7	34.8	210	291	208	8.33e-29	112	CBCO1_MOUSE	Ciliary-associated calcium-binding coiled-coil protein 1	Mus musculus (Mouse)	sperm flagellum assembly [GO:0120316]	calcium ion binding [GO:0005509]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; sperm flagellum [GO:0036126]	GO:0005509; GO:0005737; GO:0005813; GO:0036126; GO:0120316
GN020996	GN020996.1	Q13639	43.6	312	378	388	4.31e-76	243	5HT4R_HUMAN	5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4)	Homo sapiens (Human)	adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-activating serotonin receptor signaling pathway [GO:0007192]; adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; large intestinal transit [GO:0120056]; maintenance of gastrointestinal epithelium [GO:0030277]; mucus secretion [GO:0070254]; regulation of appetite [GO:0032098]; regulation of postsynapse assembly [GO:0150052]	G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; serotonin binding [GO:0051378]; serotonin receptor activity [GO:0099589]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]	GO:0004993; GO:0005737; GO:0005886; GO:0007186; GO:0007187; GO:0007189; GO:0007192; GO:0007198; GO:0007268; GO:0010008; GO:0016020; GO:0030277; GO:0030425; GO:0030594; GO:0032098; GO:0051378; GO:0070254; GO:0098794; GO:0098978; GO:0099589; GO:0120056; GO:0150052
GN020999	GN020999.1	Q32LB9	31.3	569	651	694	1.58e-71	248	NOA1_BOVIN	Nitric oxide-associated protein 1	Bos taurus (Bovine)	mitochondrial ribosome assembly [GO:0061668]; mitochondrion organization [GO:0007005]	GTP binding [GO:0005525]	mitochondrial inner membrane [GO:0005743]	GO:0005525; GO:0005743; GO:0007005; GO:0061668
GN021000	GN021000.1	A0A6I8TI61	45.0	755	919	954	3.78e-203	608	IR25A_AEDAE	Ionotropic receptor coreceptor Ir25a (Ionotropic receptor 25a)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]	coreceptor activity [GO:0015026]; ligand-gated monoatomic ion channel activity [GO:0015276]	plasma membrane [GO:0005886]	GO:0005886; GO:0007165; GO:0007608; GO:0015026; GO:0015276; GO:0050911
GN021001	GN021001.1	Q8BG19	48.9	515	780	741	1.52e-159	484	TMTC4_MOUSE	Protein O-mannosyl-transferase TMTC4 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 4) (Transmembrane and tetratricopeptide repeat-containing 4)	Mus musculus (Mouse)	endoplasmic reticulum unfolded protein response [GO:0030968]; outer hair cell apoptotic process [GO:1905584]; positive regulation of endoplasmic reticulum calcium ion concentration [GO:0032470]; protein O-linked glycosylation via mannose [GO:0035269]; sensory perception of sound [GO:0007605]	ATPase binding [GO:0051117]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; mannosyltransferase activity [GO:0000030]	endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	GO:0000030; GO:0004169; GO:0005783; GO:0007605; GO:0016020; GO:0030968; GO:0032470; GO:0035269; GO:0051117; GO:1905584
GN021003	GN021003.1	Q8N2E2	23.6	687	4131	1590	8.02e-31	138	VWDE_HUMAN	von Willebrand factor D and EGF domain-containing protein	Homo sapiens (Human)		signaling receptor binding [GO:0005102]	cell surface [GO:0009986]; extracellular region [GO:0005576]	GO:0005102; GO:0005576; GO:0009986
GN021006	GN021006.1	Q3T001	41.4	191	203	317	6.42e-38	136	H17B6_BOVIN	17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.239) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase)	Bos taurus (Bovine)	brexanolone catabolic process [GO:0062175]; retinol metabolic process [GO:0042572]	5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity [GO:0047024]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity [GO:0047044]; androsterone dehydrogenase [NAD(P)+] activity [GO:0047023]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]; testosterone dehydrogenase (NAD+) activity [GO:0047035]; testosterone dehydrogenase (NADP+) activity [GO:0047045]	endoplasmic reticulum membrane [GO:0005789]	GO:0004303; GO:0004745; GO:0005789; GO:0042572; GO:0047023; GO:0047024; GO:0047035; GO:0047044; GO:0047045; GO:0062175
GN021007	GN021007.1	Q27I66	94.3	35	566	144	1.23e-10	63.2	T22D1_BATSU	TSC22 domain family protein 1 (Transforming growth factor beta-1-induced transcript 4 protein)	Bathyergus suillus (Cape dune mole rat)	negative regulation of apoptotic process [GO:0043066]; negative regulation of hematopoietic stem cell proliferation [GO:1902034]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of transcription by RNA polymerase II [GO:0006357]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006357; GO:0008284; GO:0030511; GO:0043065; GO:0043066; GO:0043068; GO:1902034
GN021008	GN021008.1	Q6P2X9	22.7	392	468	473	3.23e-17	87.4	MOT12_XENTR	Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0046449
GN021009	GN021009.1	Q503M4	30.7	391	426	477	1.80e-35	139	MT12B_DANRE	Monocarboxylate transporter 12-B (MCT 12-B) (Solute carrier family 16 member 12-B)	Danio rerio (Zebrafish) (Brachydanio rerio)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; transmembrane transporter activity [GO:0022857]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0022857; GO:0046449
GN021010	GN021010.1	P40338	28.7	143	147	181	6.98e-10	57.8	VHL_MOUSE	von Hippel-Lindau disease tumor suppressor (pVHL)	Mus musculus (Mouse)	amyloid fibril formation [GO:1990000]; angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; camera-type eye morphogenesis [GO:0048593]; ciliary body morphogenesis [GO:0061073]; extracellular matrix organization [GO:0030198]; eye pigmentation [GO:0048069]; homeostasis of number of retina cells [GO:0048877]; iris morphogenesis [GO:0061072]; melanin metabolic process [GO:0006582]; negative regulation of autophagy [GO:0010507]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of gene expression [GO:0010629]; negative regulation of hypoxia-inducible factor-1alpha signaling pathway [GO:1902072]; negative regulation of receptor signaling pathway via JAK-STAT [GO:0046426]; negative regulation of signal transduction [GO:0009968]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; neuron differentiation [GO:0030182]; pancreatic A cell differentiation [GO:0003310]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell proliferation [GO:0050679]; proteasomal protein catabolic process [GO:0010498]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein catabolic process [GO:0030163]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of catecholamine metabolic process [GO:0042069]; regulation of cellular response to hypoxia [GO:1900037]; regulation of DNA-templated transcription [GO:0006355]; regulation of gene expression [GO:0010468]; regulation of postsynapse organization [GO:0099175]; regulation of protein localization [GO:0032880]; regulation of thymocyte apoptotic process [GO:0070243]; regulation protein catabolic process at postsynapse [GO:0140252]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; type B pancreatic cell differentiation [GO:0003309]	DNA-binding transcription factor binding [GO:0140297]; enzyme binding [GO:0019899]; molecular adaptor activity [GO:0060090]; protein serine/threonine kinase binding [GO:0120283]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; transcription elongation factor activity [GO:0003711]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	ciliary tip [GO:0097542]; cilium [GO:0005929]; Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; glutamatergic synapse [GO:0098978]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; VCB complex [GO:0030891]	GO:0000122; GO:0001525; GO:0001666; GO:0003309; GO:0003310; GO:0003711; GO:0003714; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005783; GO:0005829; GO:0005886; GO:0005929; GO:0006355; GO:0006582; GO:0008285; GO:0009968; GO:0010468; GO:0010498; GO:0010507; GO:0010629; GO:0014069; GO:0015031; GO:0015630; GO:0016567; GO:0019899; GO:0030163; GO:0030182; GO:0030198; GO:0030891; GO:0031462; GO:0032880; GO:0034244; GO:0042069; GO:0043161; GO:0043534; GO:0044877; GO:0045471; GO:0045602; GO:0045893; GO:0046426; GO:0048069; GO:0048593; GO:0048877; GO:0050679; GO:0060090; GO:0061072; GO:0061073; GO:0070243; GO:0070244; GO:0097542; GO:0098978; GO:0099175; GO:0120283; GO:0140252; GO:0140297; GO:1900037; GO:1902072; GO:1904262; GO:1990000; GO:1990756; GO:2001233
GN021011	GN021011.1	Q8R0M8	22.4	518	541	500	8.28e-33	134	MOT5_MOUSE	Probable monocarboxylate transporter 5 (MCT 5)	Mus musculus (Mouse)	carboxylic acid transmembrane transport [GO:1905039]	monocarboxylic acid transmembrane transporter activity [GO:0008028]	plasma membrane [GO:0005886]	GO:0005886; GO:0008028; GO:1905039
GN021013	GN021013.1	Q9JIW4	34.2	518	518	496	3.47e-93	295	DPOLM_MOUSE	DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase)	Mus musculus (Mouse)	B cell differentiation [GO:0030183]; DNA repair [GO:0006281]; somatic hypermutation of immunoglobulin genes [GO:0016446]	DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; magnesium ion binding [GO:0000287]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0003677; GO:0003887; GO:0005634; GO:0005654; GO:0006281; GO:0016446; GO:0030183
GN021014	GN021014.1	Q8C156	37.0	730	739	731	4.86e-108	348	CND2_MOUSE	Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (mCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog)	Mus musculus (Mouse)	B cell differentiation [GO:0030183]; cell development [GO:0048468]; female meiosis chromosome separation [GO:0051309]; female meiotic nuclear division [GO:0007143]; immunoglobulin heavy chain V-D-J recombination [GO:0071707]; meiotic chromosome condensation [GO:0010032]; meiotic chromosome segregation [GO:0045132]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of chromosome separation [GO:1905820]		chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000794; GO:0000796; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0007076; GO:0007143; GO:0010032; GO:0030183; GO:0045132; GO:0048468; GO:0051309; GO:0051984; GO:0071707; GO:1905820; GO:1905821
GN021015	GN021015.1	Q5U4W1	24.9	534	505	666	4.58e-15	81.6	LZTS2_XENLA	Leucine zipper putative tumor suppressor 2 homolog (Protein lapser1)	Xenopus laevis (African clawed frog)	microtubule severing [GO:0051013]; mitotic cytokinesis [GO:0000281]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; nuclear export [GO:0051168]; spindle midzone assembly [GO:0051255]		centrosome [GO:0005813]; cytoplasm [GO:0005737]; midbody [GO:0030496]	GO:0000281; GO:0005737; GO:0005813; GO:0030496; GO:0051013; GO:0051168; GO:0051255; GO:0090090
GN021016	GN021016.1	G5E870	56.2	822	1073	2025	8.66e-262	797	TRIPC_MOUSE	E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)	Mus musculus (Mouse)	DNA damage response [GO:0006974]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of embryonic development [GO:0045995]; ubiquitin-dependent protein catabolic process [GO:0006511]	nuclear thyroid hormone receptor binding [GO:0046966]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	GO:0000209; GO:0005654; GO:0006511; GO:0006974; GO:0008270; GO:0016607; GO:0033696; GO:0043161; GO:0045995; GO:0046966; GO:0061630; GO:0140861
GN021017	GN021017.1	Q14669	68.3	454	462	2067	1.10e-206	627	TRIPC_HUMAN	E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)	Homo sapiens (Human)	DNA damage response [GO:0006974]; DNA repair-dependent chromatin remodeling [GO:0140861]; heterochromatin boundary formation [GO:0033696]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of embryonic development [GO:0045995]; ubiquitin-dependent protein catabolic process [GO:0006511]	nuclear thyroid hormone receptor binding [GO:0046966]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000209; GO:0005634; GO:0005654; GO:0005829; GO:0006511; GO:0006974; GO:0008270; GO:0033696; GO:0043161; GO:0045995; GO:0046966; GO:0061630; GO:0140861
GN021018	GN021018.1	P00491	53.7	270	928	289	3.25e-98	312	PNPH_HUMAN	Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase)	Homo sapiens (Human)	allantoin metabolic process [GO:0000255]; dAMP catabolic process [GO:0046059]; deoxyadenosine catabolic process [GO:0006157]; deoxyguanosine catabolic process [GO:0006161]; deoxyinosine catabolic process [GO:0006149]; guanosine catabolic process [GO:0046115]; immune response [GO:0006955]; IMP catabolic process [GO:0006204]; inosine catabolic process [GO:0006148]; NAD+ biosynthetic process via the salvage pathway [GO:0034355]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; nucleotide biosynthetic process [GO:0009165]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of T cell proliferation [GO:0042102]; purine-containing compound salvage [GO:0043101]; response to xenobiotic stimulus [GO:0009410]; urate biosynthetic process [GO:0034418]	guanosine phosphorylase activity [GO:0047975]; identical protein binding [GO:0042802]; nucleoside binding [GO:0001882]; phosphate ion binding [GO:0042301]; purine nucleobase binding [GO:0002060]; purine-nucleoside phosphorylase activity [GO:0004731]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]	GO:0000255; GO:0001882; GO:0002060; GO:0004731; GO:0005576; GO:0005737; GO:0005829; GO:0006139; GO:0006148; GO:0006149; GO:0006157; GO:0006161; GO:0006204; GO:0006738; GO:0006955; GO:0009165; GO:0009410; GO:0032743; GO:0034355; GO:0034418; GO:0034774; GO:0042102; GO:0042301; GO:0042802; GO:0043101; GO:0046059; GO:0046115; GO:0046638; GO:0047975; GO:0070062; GO:1904813
GN021021	GN021021.1	Q6XDT6	57.1	49	621	505	6.01e-12	72.0	IKZF_MYXGL	Ikaros family zinc finger protein (Ikaros-like transcription factor) (HIL)	Myxine glutinosa (Atlantic hagfish)	regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity [GO:0003700]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000978; GO:0003700; GO:0005634; GO:0006357
GN021022	GN021022.1	O94993	55.6	72	195	753	2.56e-18	85.5	SOX30_HUMAN	Transcription factor SOX-30	Homo sapiens (Human)	negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proacrosomal vesicle fusion [GO:0120211]; regulation of transcription by RNA polymerase II [GO:0006357]; response to corticosteroid [GO:0031960]; spermatid development [GO:0007286]	beta-catenin binding [GO:0008013]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; chromocenter [GO:0010369]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000978; GO:0000981; GO:0001227; GO:0001228; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006357; GO:0007286; GO:0008013; GO:0010369; GO:0030178; GO:0031960; GO:0045944; GO:0120211; GO:1990837
GN021023	GN021023.1	P13051	65.1	255	316	313	2.45e-118	346	UNG_HUMAN	Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)	Homo sapiens (Human)	base-excision repair [GO:0006284]; base-excision repair, AP site formation via deaminated base removal [GO:0097510]; depyrimidination [GO:0045008]; negative regulation of apoptotic process [GO:0043066]; single strand break repair [GO:0000012]	damaged DNA binding [GO:0003684]; ribosomal small subunit binding [GO:0043024]; uracil DNA N-glycosylase activity [GO:0004844]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000012; GO:0003684; GO:0004844; GO:0005634; GO:0005654; GO:0005739; GO:0006284; GO:0043024; GO:0043066; GO:0045008; GO:0097510
GN021024	GN021024.1	P0DUE1	53.9	128	163	415	1.76e-33	125	STING_MAGGI	Stimulator of interferon genes protein (TIR-STING) (Probable NAD(+) hydrolase) (EC 3.2.2.6)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	activation of innate immune response [GO:0002218]; autophagosome assembly [GO:0000045]; innate immune response [GO:0045087]; positive regulation of macroautophagy [GO:0016239]; positive regulation of type I interferon production [GO:0032481]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; NAD+ nucleosidase activity, cyclic ADP-ribose generating [GO:0061809]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]	GO:0000045; GO:0002218; GO:0005776; GO:0005789; GO:0007165; GO:0016239; GO:0032481; GO:0035438; GO:0045087; GO:0061507; GO:0061709; GO:0061809
GN021025	GN021025.1	P0DUE1	65.0	397	412	415	1.06e-190	537	STING_MAGGI	Stimulator of interferon genes protein (TIR-STING) (Probable NAD(+) hydrolase) (EC 3.2.2.6)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	activation of innate immune response [GO:0002218]; autophagosome assembly [GO:0000045]; innate immune response [GO:0045087]; positive regulation of macroautophagy [GO:0016239]; positive regulation of type I interferon production [GO:0032481]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; NAD+ nucleosidase activity, cyclic ADP-ribose generating [GO:0061809]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]	GO:0000045; GO:0002218; GO:0005776; GO:0005789; GO:0007165; GO:0016239; GO:0032481; GO:0035438; GO:0045087; GO:0061507; GO:0061709; GO:0061809
GN021027	GN021027.1	P0DUE1	54.7	128	163	415	4.63e-34	126	STING_MAGGI	Stimulator of interferon genes protein (TIR-STING) (Probable NAD(+) hydrolase) (EC 3.2.2.6)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	activation of innate immune response [GO:0002218]; autophagosome assembly [GO:0000045]; innate immune response [GO:0045087]; positive regulation of macroautophagy [GO:0016239]; positive regulation of type I interferon production [GO:0032481]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; NAD+ nucleosidase activity, cyclic ADP-ribose generating [GO:0061809]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]	GO:0000045; GO:0002218; GO:0005776; GO:0005789; GO:0007165; GO:0016239; GO:0032481; GO:0035438; GO:0045087; GO:0061507; GO:0061709; GO:0061809
GN021028	GN021028.1	P0DUE1	54.7	128	141	415	1.45e-35	129	STING_MAGGI	Stimulator of interferon genes protein (TIR-STING) (Probable NAD(+) hydrolase) (EC 3.2.2.6)	Magallana gigas (Pacific oyster) (Crassostrea gigas)	activation of innate immune response [GO:0002218]; autophagosome assembly [GO:0000045]; innate immune response [GO:0045087]; positive regulation of macroautophagy [GO:0016239]; positive regulation of type I interferon production [GO:0032481]; reticulophagy [GO:0061709]; signal transduction [GO:0007165]	2',3'-cyclic GMP-AMP binding [GO:0061507]; cyclic-di-GMP binding [GO:0035438]; NAD+ nucleosidase activity, cyclic ADP-ribose generating [GO:0061809]	autophagosome [GO:0005776]; endoplasmic reticulum membrane [GO:0005789]	GO:0000045; GO:0002218; GO:0005776; GO:0005789; GO:0007165; GO:0016239; GO:0032481; GO:0035438; GO:0045087; GO:0061507; GO:0061709; GO:0061809
GN021029	GN021029.1	Q7T308	50.9	116	848	474	1.51e-31	132	RN168_DANRE	E3 ubiquitin-protein ligase rnf168 (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase rnf168)	Danio rerio (Zebrafish) (Brachydanio rerio)	DNA damage response [GO:0006974]; DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; isotype switching [GO:0045190]; negative regulation of transcription elongation by RNA polymerase II [GO:0034244]; positive regulation of DNA repair [GO:0045739]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212]; ubiquitin-dependent protein catabolic process [GO:0006511]	chromatin binding [GO:0003682]; histone binding [GO:0042393]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; nucleosome binding [GO:0031491]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]	nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0003682; GO:0004842; GO:0005634; GO:0006302; GO:0006511; GO:0006974; GO:0010212; GO:0016567; GO:0031491; GO:0034244; GO:0035861; GO:0042393; GO:0043130; GO:0045190; GO:0045739; GO:0061630; GO:0070530; GO:0070534; GO:0140861
GN021030	GN021030.1	Q14573	22.6	800	1195	2671	6.41e-27	123	ITPR3_HUMAN	Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)	Homo sapiens (Human)	calcium ion homeostasis [GO:0055074]; G protein-coupled receptor signaling pathway [GO:0007186]; platelet activation [GO:0030168]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein homotetramerization [GO:0051289]; release of sequestered calcium ion into cytosol [GO:0051209]; response to calcium ion [GO:0051592]; sensory perception of taste [GO:0050909]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; inositol 1,3,4,5 tetrakisphosphate binding [GO:0043533]; inositol 1,4,5 trisphosphate binding [GO:0070679]; inositol 1,4,5-trisphosphate-gated calcium channel activity [GO:0005220]; inositol hexakisphosphate binding [GO:0000822]; intracellularly gated calcium channel activity [GO:0015278]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270]	apical part of cell [GO:0045177]; brush border [GO:0005903]; cytoplasm [GO:0005737]; cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear outer membrane [GO:0005640]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; platelet dense tubular network membrane [GO:0031095]; sarcoplasmic reticulum [GO:0016529]; secretory granule membrane [GO:0030667]; signaling receptor complex [GO:0043235]; transport vesicle membrane [GO:0030658]	GO:0000822; GO:0005220; GO:0005509; GO:0005524; GO:0005640; GO:0005654; GO:0005730; GO:0005737; GO:0005783; GO:0005789; GO:0005886; GO:0005903; GO:0007186; GO:0007204; GO:0008270; GO:0015278; GO:0016020; GO:0016529; GO:0030168; GO:0030658; GO:0030667; GO:0031095; GO:0035091; GO:0043025; GO:0043235; GO:0043533; GO:0045177; GO:0050909; GO:0051209; GO:0051289; GO:0051592; GO:0055074; GO:0070679; GO:0098554
GN021036	GN021036.1	Q8VHT6	48.9	368	368	369	1.01e-124	366	AS3MT_RAT	Arsenite methyltransferase (EC 2.1.1.137) (Methylarsonite methyltransferase) (S-adenosyl-L-methionine:arsenic(III) methyltransferase)	Rattus norvegicus (Rat)	arsonoacetate metabolic process [GO:0018872]; methylation [GO:0032259]; response to arsenic-containing substance [GO:0046685]; toxin metabolic process [GO:0009404]	arsenite methyltransferase activity [GO:0030791]; protein methyltransferase activity [GO:0008276]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]	cytosol [GO:0005829]	GO:0005829; GO:0008276; GO:0008757; GO:0009404; GO:0018872; GO:0030791; GO:0032259; GO:0046685
GN021037	GN021037.1	Q9D2V8	46.0	443	458	456	9.95e-134	396	S75A1_MOUSE	Solute carrier family 75 member 1 (Major facilitator superfamily domain-containing protein 10) (Tetracycline transporter-like protein)	Mus musculus (Mouse)	sodium-independent organic anion transport [GO:0043252]	transmembrane transporter activity [GO:0022857]	brush border membrane [GO:0031526]; cytoplasmic vesicle membrane [GO:0030659]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]	GO:0005637; GO:0005886; GO:0022857; GO:0030659; GO:0031526; GO:0043252
GN021049	GN021049.1	Q9C056	50.7	73	103	277	1.82e-10	58.9	NKX62_HUMAN	Homeobox protein Nkx-6.2 (Homeobox protein NK-6 homolog B)	Homo sapiens (Human)	cell differentiation [GO:0030154]; negative regulation of DNA-templated transcription [GO:0045892]; regulation of DNA-templated transcription [GO:0006355]; regulation of myelination [GO:0031641]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0001227; GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0006357; GO:0030154; GO:0031641; GO:0045892; GO:1990837
GN021050	GN021050.1	Q6UWZ7	26.8	254	553	409	4.09e-20	96.3	ABRX1_HUMAN	BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A)	Homo sapiens (Human)	attachment of spindle microtubules to kinetochore [GO:0008608]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; mitotic G2/M transition checkpoint [GO:0044818]; mitotic spindle assembly [GO:0090307]; positive regulation of DNA repair [GO:0045739]; regulation of DNA repair [GO:0006282]; response to ionizing radiation [GO:0010212]	microtubule binding [GO:0008017]; polyubiquitin modification-dependent protein binding [GO:0031593]	BRCA1-A complex [GO:0070531]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0006282; GO:0006302; GO:0007095; GO:0008017; GO:0008608; GO:0010212; GO:0016604; GO:0031593; GO:0044818; GO:0045739; GO:0070531; GO:0090307
GN021052	GN021052.1	Q0P5B7	35.3	405	406	399	4.99e-61	205	AAAD_BOVIN	Deacylase AADAC (EC 3.-.-.-) (50 kDa microsomal esterase/N-deacetylase) (Acetylesterase AADAC) (EC 3.1.1.6) (Arylacetamide deacetylase) (Arylalkyl acylamidase AADAC) (EC 3.5.1.76) (Diacylglycerol lipase activity AADAC) (EC 3.1.1.79)	Bos taurus (Bovine)	positive regulation of triglyceride catabolic process [GO:0010898]	serine hydrolase activity [GO:0017171]; triacylglycerol lipase activity [GO:0004806]	endoplasmic reticulum membrane [GO:0005789]	GO:0004806; GO:0005789; GO:0010898; GO:0017171
GN021053	GN021053.1	Q6PBN5	35.0	226	217	423	5.12e-24	101	AUP1_DANRE	Lipid droplet-regulating VLDL assembly factor AUP1 (Ancient ubiquitous protein 1)	Danio rerio (Zebrafish) (Brachydanio rerio)	ERAD pathway [GO:0036503]; lipid droplet formation [GO:0140042]; lipid droplet organization [GO:0034389]; protein localization to lipid droplet [GO:1990044]	ubiquitin binding [GO:0043130]	endoplasmic reticulum membrane [GO:0005789]; lipid droplet [GO:0005811]	GO:0005789; GO:0005811; GO:0034389; GO:0036503; GO:0043130; GO:0140042; GO:1990044
GN021056	GN021056.1	Q9HCL2	34.9	794	851	828	5.20e-134	422	GPAT1_HUMAN	Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15)	Homo sapiens (Human)	CDP-diacylglycerol biosynthetic process [GO:0016024]; diacylglycerol biosynthetic process [GO:0006651]; glycerophospholipid metabolic process [GO:0006650]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylglycerol biosynthetic process [GO:0006655]; triglyceride biosynthetic process [GO:0019432]	glycerol-3-phosphate O-acyltransferase activity [GO:0004366]	mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0004366; GO:0005739; GO:0005741; GO:0005886; GO:0006650; GO:0006651; GO:0006654; GO:0006655; GO:0016024; GO:0019432
GN021057	GN021057.1	Q02645	45.7	598	840	1156	4.89e-165	513	HTS_DROME	Protein hu-li tai shao (Adducin-like protein)	Drosophila melanogaster (Fruit fly)	actin filament bundle organization [GO:0061572]; adult somatic muscle development [GO:0007527]; axon guidance [GO:0007411]; centrosome cycle [GO:0007098]; cystoblast division [GO:0007282]; female germ-line cyst formation [GO:0048135]; female germline ring canal formation, actin assembly [GO:0008302]; fusome organization [GO:0045478]; germ-line cyst formation [GO:0048134]; germarium-derived oocyte fate determination [GO:0007294]; meiotic spindle organization [GO:0000212]; oogenesis [GO:0048477]; ovarian fusome organization [GO:0030723]; photoreceptor cell axon guidance [GO:0072499]; postsynapse organization [GO:0099173]; sarcomere organization [GO:0045214]; testicular fusome organization [GO:0030724]	actin filament binding [GO:0051015]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; female germline ring canal inner rim [GO:0035183]; fusome [GO:0045169]; germline ring canal [GO:0045172]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; spectrosome [GO:0045170]	GO:0000212; GO:0005737; GO:0005856; GO:0005886; GO:0007098; GO:0007282; GO:0007294; GO:0007411; GO:0007527; GO:0008302; GO:0014069; GO:0016328; GO:0030723; GO:0030724; GO:0035183; GO:0045169; GO:0045170; GO:0045172; GO:0045214; GO:0045478; GO:0048134; GO:0048135; GO:0048477; GO:0051015; GO:0061572; GO:0072499; GO:0098793; GO:0098794; GO:0099173
GN021058	GN021058.1	Q9YHB5	41.9	904	1684	1034	1.96e-207	645	CND3_XENLA	Condensin complex subunit 3 (Chromosome assembly protein xCAP-G) (Chromosome-associated protein G) (Condensin subunit CAP-G) (Non-SMC condensin I complex subunit G)	Xenopus laevis (African clawed frog)	mitotic chromosome condensation [GO:0007076]		condensed chromosome [GO:0000793]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0000793; GO:0000796; GO:0005634; GO:0005737; GO:0005829; GO:0007076
GN021059	GN021059.1	Q18785	32.1	78	96	120	2.22e-09	53.5	MIF2_CAEEL	MIF-like protein mif-2	Caenorhabditis elegans		cytokine activity [GO:0005125]; phenylpyruvate tautomerase activity [GO:0050178]		GO:0005125; GO:0050178
GN021060	GN021060.1	Q5PQR6	29.6	318	338	454	8.71e-22	99.0	SMA2L_RAT	Sperm microtubule associated protein 2-like (Testicular haploid expressed gene protein-like) (Theg spermatid-like protein)	Rattus norvegicus (Rat)				
GN021064	GN021064.1	O43711	62.8	196	264	291	1.95e-62	201	TLX3_HUMAN	T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2)	Homo sapiens (Human)	animal organ development [GO:0048513]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000981; GO:0005634; GO:0005654; GO:0006357; GO:0048513; GO:1990837
GN021065	GN021065.1	O43711	70.6	102	235	291	9.66e-42	146	TLX3_HUMAN	T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2)	Homo sapiens (Human)	animal organ development [GO:0048513]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific double-stranded DNA binding [GO:1990837]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0000981; GO:0005634; GO:0005654; GO:0006357; GO:0048513; GO:1990837
GN021066	GN021066.1	Q0P5B7	29.4	415	429	399	3.59e-48	172	AAAD_BOVIN	Deacylase AADAC (EC 3.-.-.-) (50 kDa microsomal esterase/N-deacetylase) (Acetylesterase AADAC) (EC 3.1.1.6) (Arylacetamide deacetylase) (Arylalkyl acylamidase AADAC) (EC 3.5.1.76) (Diacylglycerol lipase activity AADAC) (EC 3.1.1.79)	Bos taurus (Bovine)	positive regulation of triglyceride catabolic process [GO:0010898]	serine hydrolase activity [GO:0017171]; triacylglycerol lipase activity [GO:0004806]	endoplasmic reticulum membrane [GO:0005789]	GO:0004806; GO:0005789; GO:0010898; GO:0017171
GN021067	GN021067.1	Q0P5B7	28.9	415	429	399	7.45e-46	166	AAAD_BOVIN	Deacylase AADAC (EC 3.-.-.-) (50 kDa microsomal esterase/N-deacetylase) (Acetylesterase AADAC) (EC 3.1.1.6) (Arylacetamide deacetylase) (Arylalkyl acylamidase AADAC) (EC 3.5.1.76) (Diacylglycerol lipase activity AADAC) (EC 3.1.1.79)	Bos taurus (Bovine)	positive regulation of triglyceride catabolic process [GO:0010898]	serine hydrolase activity [GO:0017171]; triacylglycerol lipase activity [GO:0004806]	endoplasmic reticulum membrane [GO:0005789]	GO:0004806; GO:0005789; GO:0010898; GO:0017171
GN021068	GN021068.1	Q0P5B7	33.2	401	429	399	1.83e-55	191	AAAD_BOVIN	Deacylase AADAC (EC 3.-.-.-) (50 kDa microsomal esterase/N-deacetylase) (Acetylesterase AADAC) (EC 3.1.1.6) (Arylacetamide deacetylase) (Arylalkyl acylamidase AADAC) (EC 3.5.1.76) (Diacylglycerol lipase activity AADAC) (EC 3.1.1.79)	Bos taurus (Bovine)	positive regulation of triglyceride catabolic process [GO:0010898]	serine hydrolase activity [GO:0017171]; triacylglycerol lipase activity [GO:0004806]	endoplasmic reticulum membrane [GO:0005789]	GO:0004806; GO:0005789; GO:0010898; GO:0017171
GN021069	GN021069.1	Q6GN91	50.0	422	435	499	9.83e-149	435	NT5D3_XENLA	5'-nucleotidase domain-containing protein 3 (EC 3.1.3.-)	Xenopus laevis (African clawed frog)		5'-nucleotidase activity [GO:0008253]; phosphatase activity [GO:0016791]		GO:0008253; GO:0016791
GN021070	GN021070.1	Q9WTW8	48.5	559	609	647	7.83e-176	516	S23A2_RAT	Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2)	Rattus norvegicus (Rat)	blood circulation [GO:0008015]; cellular response to ethanol [GO:0071361]; L-ascorbic acid metabolic process [GO:0019852]; L-ascorbic acid transmembrane transport [GO:0015882]; positive regulation of dendrite extension [GO:1903861]; response to oxidative stress [GO:0006979]	L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0006979; GO:0008015; GO:0008520; GO:0009925; GO:0015229; GO:0015882; GO:0016323; GO:0016324; GO:0019852; GO:0071361; GO:1903861
GN021071	GN021071.1	O42115	74.4	43	161	453	4.73e-13	68.9	ARXA_DANRE	Aristaless-related homeobox protein A (ARX-A)	Danio rerio (Zebrafish) (Brachydanio rerio)	intestinal type D enteroendocrine cell differentiation [GO:7770025]; intestinal type G enteroendocrine cell differentiation [GO:7770021]; intestinal type I enteroendocrine cell differentiation [GO:7770022]; intestinal type L enteroendocrine cell differentiation [GO:7770023]; intestinal type N enteroendocrine cell differentiation [GO:7770024]; neuron development [GO:0048666]; pancreatic A cell development [GO:0003322]; pancreatic A cell differentiation [GO:0003310]; regulation of neuronal action potential [GO:0098908]; regulation of transcription by RNA polymerase II [GO:0006357]; subthalamus development [GO:0021539]; telencephalon development [GO:0021537]; thalamus development [GO:0021794]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000981; GO:0003310; GO:0003322; GO:0005634; GO:0006357; GO:0021537; GO:0021539; GO:0021794; GO:0048666; GO:0098908; GO:7770021; GO:7770022; GO:7770023; GO:7770024; GO:7770025
GN021072	GN021072.1	Q00945	44.9	107	108	155	8.25e-14	66.2	CONO_LYMST	Conopressin/neurophysin [Cleaved into: Lys-conopressin G; Neurophysin]	Lymnaea stagnalis (Great pond snail) (Helix stagnalis)		neurohypophyseal hormone activity [GO:0005185]	extracellular region [GO:0005576]; secretory granule [GO:0030141]	GO:0005185; GO:0005576; GO:0030141
GN021073	GN021073.1	H2A0M7	35.8	620	727	793	7.29e-110	354	PLSP_PINMG	Peroxidase-like protein	Margaritifera margaritifera (Freshwater pearl mussel)	response to oxidative stress [GO:0006979]	heme binding [GO:0020037]; peroxidase activity [GO:0004601]	extracellular region [GO:0005576]	GO:0004601; GO:0005576; GO:0006979; GO:0020037
GN021074	GN021074.1	O43736	34.5	110	315	263	1.29e-12	70.1	ITM2A_HUMAN	Integral membrane protein 2A (Protein E25)	Homo sapiens (Human)	negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]	amyloid-beta binding [GO:0001540]	Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	GO:0001540; GO:0005794; GO:0005886; GO:0042985
GN021075	GN021075.1	Q8R0M8	25.1	514	531	500	2.13e-33	136	MOT5_MOUSE	Probable monocarboxylate transporter 5 (MCT 5)	Mus musculus (Mouse)	carboxylic acid transmembrane transport [GO:1905039]	monocarboxylic acid transmembrane transporter activity [GO:0008028]	plasma membrane [GO:0005886]	GO:0005886; GO:0008028; GO:1905039
GN021076	GN021076.1	Q8WPJ2	50.8	331	342	367	2.76e-117	346	MANA_MYTED	Mannan endo-1,4-beta-mannosidase (EC 3.2.1.78) (Beta-mannanase) (Endo-beta-1,4-mannanase) (Man5A) (ManA)	Mytilus edulis (Blue mussel)	mannan catabolic process [GO:0046355]	mannan endo-1,4-beta-mannosidase activity [GO:0016985]		GO:0016985; GO:0046355
GN021077	GN021077.1	Q9NX58	41.3	378	906	379	2.84e-39	153	LYAR_HUMAN	Cell growth-regulating nucleolar protein	Homo sapiens (Human)	erythrocyte development [GO:0048821]; negative regulation of innate immune response [GO:0045824]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of phagocytosis [GO:0050766]; positive regulation of transcription by RNA polymerase I [GO:0045943]; rRNA processing [GO:0006364]	DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; transcription regulator inhibitor activity [GO:0140416]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor outer segment [GO:0001750]	GO:0000122; GO:0001750; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0042802; GO:0045824; GO:0045943; GO:0048821; GO:0050766; GO:0140297; GO:0140416
GN021079	GN021079.1	Q8N9I9	55.1	136	148	347	1.68e-46	157	DTX3_HUMAN	E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)	Homo sapiens (Human)	Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]	ubiquitin protein ligase activity [GO:0061630]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0007219; GO:0008593; GO:0016567; GO:0061630
GN021080	GN021080.1	Q90788	64.7	136	342	294	6.43e-44	155	NKX25_CHICK	Homeobox protein Nkx-2.5 (cNKx-2.5) (Homeobox protein NK-2 homolog E)	Gallus gallus (Chicken)	adult heart development [GO:0007512]; atrial cardiac muscle tissue development [GO:0003228]; atrial septum morphogenesis [GO:0060413]; atrioventricular node development [GO:0003162]; cardiac muscle cell development [GO:0055013]; cell differentiation [GO:0030154]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of gene expression [GO:0010628]; positive regulation of heart contraction [GO:0045823]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction [GO:0055117]; regulation of transcription by RNA polymerase II [GO:0006357]; response to BMP [GO:0071772]; right ventricular cardiac muscle tissue morphogenesis [GO:0003221]; septum secundum development [GO:0003285]; spleen development [GO:0048536]; thyroid gland development [GO:0030878]; ventricular septum morphogenesis [GO:0060412]	chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein homodimerization activity [GO:0042803]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]	cytoplasm [GO:0005737]; Nkx-2.5 complex [GO:1990664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]	GO:0000122; GO:0000978; GO:0000981; GO:0001228; GO:0003148; GO:0003162; GO:0003221; GO:0003228; GO:0003285; GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0007512; GO:0010628; GO:0010667; GO:0010765; GO:0010832; GO:0030154; GO:0030878; GO:0032991; GO:0032993; GO:0042803; GO:0045666; GO:0045823; GO:0048536; GO:0051891; GO:0055013; GO:0055117; GO:0060261; GO:0060412; GO:0060413; GO:0061629; GO:0071772; GO:0090090; GO:1903779; GO:1990664
GN021081	GN021081.1	Q6NZW8	39.4	132	249	186	2.27e-25	101	AR8BA_DANRE	ADP-ribosylation factor-like protein 8B-A	Danio rerio (Zebrafish) (Brachydanio rerio)	anterograde axonal transport [GO:0008089]; autophagosome-lysosome fusion [GO:0061909]; late endosome to lysosome transport [GO:1902774]; lysosome localization [GO:0032418]; protein transport [GO:0015031]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]	axon cytoplasm [GO:1904115]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; spindle [GO:0005819]	GO:0003924; GO:0005525; GO:0005764; GO:0005765; GO:0005819; GO:0008089; GO:0015031; GO:0031901; GO:0031902; GO:0032418; GO:0061909; GO:1902774; GO:1904115
GN021082	GN021082.1	F4IF36	37.9	1125	1233	1295	2.51e-221	677	FGT1_ARATH	Protein FORGETTER 1 (Protein EMBRYO DEFECTIVE 1135)	Arabidopsis thaliana (Mouse-ear cress)	chromatin remodeling [GO:0006338]; epigenetic regulation of gene expression [GO:0040029]; heat acclimation [GO:0010286]; positive regulation of cellular response to heat [GO:1900036]; regulation of DNA-templated transcription [GO:0006355]; response to heat [GO:0009408]	chromatin DNA binding [GO:0031490]; histone binding [GO:0042393]; promoter-specific chromatin binding [GO:1990841]	nucleus [GO:0005634]	GO:0005634; GO:0006338; GO:0006355; GO:0009408; GO:0010286; GO:0031490; GO:0040029; GO:0042393; GO:1900036; GO:1990841
GN021086	GN021086.1	O43143	84.1	678	726	795	0.0	1166	DHX15_HUMAN	ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43)	Homo sapiens (Human)	antiviral innate immune response [GO:0140374]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; response to alkaloid [GO:0043279]; response to toxic substance [GO:0009636]; RNA splicing [GO:0008380]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent activity, acting on RNA [GO:0008186]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]	nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]	GO:0000398; GO:0003723; GO:0003724; GO:0003725; GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005681; GO:0005689; GO:0005730; GO:0006397; GO:0008186; GO:0008380; GO:0009636; GO:0016607; GO:0016887; GO:0042742; GO:0043123; GO:0043279; GO:0051607; GO:0071014; GO:0140374
GN021087	GN021087.1	Q3SZ40	57.3	525	643	546	1.74e-192	556	DDX56_BOVIN	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.4.13) (DEAD box protein 56)	Bos taurus (Bovine)		ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724]	nucleolus [GO:0005730]	GO:0003676; GO:0003724; GO:0005524; GO:0005730; GO:0016887
GN021088	GN021088.1	O73810	35.2	475	540	436	6.73e-67	226	DRD2_MELGA	Dopamine receptor D2 (Dopamine D2 receptor)	Meleagris gallopavo (Wild turkey)	adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; hyaloid vascular plexus regression [GO:1990384]; negative regulation of calcium ion transport into cytosol [GO:0010523]; negative regulation of peptide hormone secretion [GO:0090278]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; regulation of defecation [GO:2000292]; regulation of dopamine secretion [GO:0014059]; regulation of potassium ion transport [GO:0043266]	dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; G protein-coupled receptor activity [GO:0004930]; signaling receptor activity [GO:0038023]	glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	GO:0000139; GO:0001591; GO:0004930; GO:0005886; GO:0007195; GO:0010523; GO:0014059; GO:0035240; GO:0038023; GO:0042734; GO:0043266; GO:0045211; GO:0051967; GO:0060158; GO:0090278; GO:0098978; GO:1990384; GO:2000292
GN021089	GN021089.1	P14842	44.7	197	863	471	8.94e-41	160	5HT2A_RAT	5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A)	Rattus norvegicus (Rat)	artery smooth muscle contraction [GO:0014824]; behavioral response to cocaine [GO:0048148]; chemical synaptic transmission [GO:0007268]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; G protein-coupled serotonin receptor signaling pathway [GO:0098664]; intracellular calcium ion homeostasis [GO:0006874]; memory [GO:0007613]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glycolytic process [GO:0045821]; positive regulation of heat generation [GO:0031652]; positive regulation of inflammatory response [GO:0050729]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; positive regulation of platelet aggregation [GO:1901731]; positive regulation of vasoconstriction [GO:0045907]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein localization to cytoskeleton [GO:0044380]; regulation of dopamine secretion [GO:0014059]; release of sequestered calcium ion into cytosol [GO:0051209]; response to cocaine [GO:0042220]; response to xenobiotic stimulus [GO:0009410]; sensitization [GO:0046960]; sensory perception of temperature stimulus [GO:0050951]; serotonin receptor signaling pathway [GO:0007210]; temperature homeostasis [GO:0001659]; urinary bladder smooth muscle contraction [GO:0014832]	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding [GO:0071886]; G protein-coupled serotonin receptor activity [GO:0004993]; Gq/11-coupled serotonin receptor activity [GO:0001587]; identical protein binding [GO:0042802]; neurotransmitter receptor activity [GO:0030594]; protein tyrosine kinase activator activity [GO:0030296]; protein-containing complex binding [GO:0044877]; serotonin binding [GO:0051378]	axon [GO:0030424]; caveola [GO:0005901]; cell body fiber [GO:0070852]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; G protein-coupled serotonin receptor complex [GO:0098666]; glutamatergic synapse [GO:0098978]; neurofilament [GO:0005883]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]	GO:0001587; GO:0001659; GO:0002720; GO:0004993; GO:0005883; GO:0005886; GO:0005901; GO:0006874; GO:0007187; GO:0007204; GO:0007208; GO:0007210; GO:0007268; GO:0007613; GO:0008284; GO:0009410; GO:0010513; GO:0014059; GO:0014824; GO:0014832; GO:0030296; GO:0030424; GO:0030425; GO:0030594; GO:0031410; GO:0031652; GO:0042220; GO:0042734; GO:0042802; GO:0043025; GO:0043198; GO:0043267; GO:0043406; GO:0043525; GO:0044380; GO:0044877; GO:0045211; GO:0045600; GO:0045821; GO:0045907; GO:0046960; GO:0048148; GO:0050729; GO:0050731; GO:0050951; GO:0050965; GO:0050966; GO:0051209; GO:0051378; GO:0051967; GO:0070374; GO:0070852; GO:0071886; GO:0098664; GO:0098666; GO:0098793; GO:0098978; GO:0099171; GO:1900119; GO:1901731; GO:2000573
GN021090	GN021090.1	Q3TXS7	71.5	606	616	953	2.18e-294	830	PSMD1_MOUSE	26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1)	Mus musculus (Mouse)	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of AMPA receptor activity [GO:2000311]; regulation of protein catabolic process [GO:0042176]	enzyme regulator activity [GO:0030234]; ubiquitin protein ligase binding [GO:0031625]	proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome storage granule [GO:0034515]; synaptic vesicle [GO:0008021]	GO:0000502; GO:0008021; GO:0022624; GO:0030234; GO:0031625; GO:0034515; GO:0042176; GO:0043161; GO:2000311
GN021093	GN021093.1	P78316	47.8	291	279	857	7.09e-57	198	NOP14_HUMAN	Nucleolar protein 14 (Nucleolar complex protein 14)	Homo sapiens (Human)	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; protein localization to nucleolus [GO:1902570]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]	enzyme binding [GO:0019899]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]	90S preribosome [GO:0030686]; membrane [GO:0016020]; Noc4p-Nop14p complex [GO:0030692]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	GO:0000447; GO:0000462; GO:0000472; GO:0000480; GO:0003723; GO:0005654; GO:0005730; GO:0006364; GO:0016020; GO:0019899; GO:0030490; GO:0030515; GO:0030686; GO:0030692; GO:0032040; GO:0042274; GO:1902570
GN021094	GN021094.1	Q8R3N1	38.2	338	332	860	2.31e-53	191	NOP14_MOUSE	Nucleolar protein 14 (Nucleolar complex protein 14)	Mus musculus (Mouse)	maturation of SSU-rRNA [GO:0030490]; protein localization to nucleolus [GO:1902570]; ribosomal small subunit biogenesis [GO:0042274]	enzyme binding [GO:0019899]; snoRNA binding [GO:0030515]	Noc4p-Nop14p complex [GO:0030692]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]	GO:0005654; GO:0005730; GO:0019899; GO:0030490; GO:0030515; GO:0030692; GO:0032040; GO:0042274; GO:1902570
GN021095	GN021095.1	P48430	52.5	301	331	315	9.95e-70	223	SOX2_CHICK	Transcription factor SOX-2 (cSox2) (delta EF2a)	Gallus gallus (Chicken)	brain development [GO:0007420]; cell fate commitment [GO:0045165]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; sensory organ precursor cell fate determination [GO:0016360]	DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0001228; GO:0005634; GO:0005654; GO:0005737; GO:0007420; GO:0016360; GO:0030182; GO:0043565; GO:0045165; GO:0045665; GO:0045893; GO:0045944
GN021097	GN021097.1	Q6NTV9	54.8	146	156	149	2.05e-50	161	NHP2_XENLA	H/ACA ribonucleoprotein complex subunit 2-like protein (Nucleolar protein family A member 2-like protein) (snoRNP protein NHP2-like protein)	Xenopus laevis (African clawed frog)	rRNA pseudouridine synthesis [GO:0031118]; snRNA pseudouridine synthesis [GO:0031120]; telomere maintenance via telomerase [GO:0007004]	box H/ACA snoRNA binding [GO:0034513]	box H/ACA snoRNP complex [GO:0031429]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]; telomerase holoenzyme complex [GO:0005697]	GO:0005697; GO:0005732; GO:0007004; GO:0031118; GO:0031120; GO:0031429; GO:0034513
GN021099	GN021099.1	A4FUB0	25.0	755	1147	638	2.41e-47	184	CE034_BOVIN	Uncharacterized protein C5orf34 homolog	Bos taurus (Bovine)				
GN021100	GN021100.1	Q9VTZ5	33.6	771	738	819	7.26e-142	439	TRFM_DROME	Transferrin 2 (Melanotransferrin)	Drosophila melanogaster (Fruit fly)	iron ion transport [GO:0006826]; septate junction assembly [GO:0019991]	iron ion binding [GO:0005506]	apicolateral plasma membrane [GO:0016327]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; septate junction [GO:0005918]	GO:0005506; GO:0005576; GO:0005769; GO:0005829; GO:0005886; GO:0005918; GO:0006826; GO:0016327; GO:0019991; GO:0055037
GN021101	GN021101.1	Q5XJ54	72.4	203	228	326	1.74e-105	310	GLRX3_DANRE	Glutaredoxin 3	Danio rerio (Zebrafish) (Brachydanio rerio)	hemoglobin metabolic process [GO:0020027]; intracellular iron ion homeostasis [GO:0006879]; multicellular organismal-level iron ion homeostasis [GO:0060586]		cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005829; GO:0006879; GO:0020027; GO:0060586
GN021102	GN021102.1	Q58DA7	50.0	120	130	334	6.96e-30	112	GLRX3_BOVIN	Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (Thioredoxin-like protein 2)	Bos taurus (Bovine)	intracellular iron ion homeostasis [GO:0006879]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; regulation of the force of heart contraction [GO:0002026]		cell cortex [GO:0005938]; cytosol [GO:0005829]; nucleus [GO:0005634]; Z disc [GO:0030018]	GO:0002026; GO:0005634; GO:0005829; GO:0005938; GO:0006879; GO:0010614; GO:0030018
GN021104	GN021104.1	Q9R062	58.3	278	555	333	2.36e-105	322	GLYG_MOUSE	Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186)	Mus musculus (Mouse)	glycogen biosynthetic process [GO:0005978]; glycogen biosynthetic process via UDP-glucose [GO:0160249]	D-glucose binding [GO:0005536]; glycogenin glucosyltransferase activity [GO:0008466]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]	catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005536; GO:0005634; GO:0005737; GO:0005978; GO:0008466; GO:0030145; GO:0042803; GO:0160249; GO:1902494
GN021105	GN021105.1	O73787	52.4	905	908	906	7.57e-306	869	GCP3_XENLA	Gamma-tubulin complex component 3 homolog (Gamma-ring complex protein 109) (Xgrip109) (x109p)	Xenopus laevis (African clawed frog)	cytoplasmic microtubule organization [GO:0031122]; meiotic cell cycle [GO:0051321]; microtubule nucleation [GO:0007020]; mitotic cell cycle [GO:0000278]; spindle assembly [GO:0051225]	gamma-tubulin binding [GO:0043015]; microtubule minus-end binding [GO:0051011]	centrosome [GO:0005813]; gamma-tubulin complex [GO:0000930]; spindle pole [GO:0000922]	GO:0000278; GO:0000922; GO:0000930; GO:0005813; GO:0007020; GO:0031122; GO:0043015; GO:0051011; GO:0051225; GO:0051321
GN021107	GN021107.1	Q56R14	23.9	301	644	1091	1.95e-14	80.9	TRI33_XENLA	E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)	Xenopus laevis (African clawed frog)	protein ubiquitination [GO:0016567]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0008270; GO:0016567; GO:0061630
GN021108	GN021108.1	Q676U5	33.5	492	501	607	2.71e-72	243	A16L1_HUMAN	Autophagy-related protein 16-1 (APG16-like 1)	Homo sapiens (Human)	autophagosome assembly [GO:0000045]; axonal transport [GO:0098930]; C-terminal protein lipidation [GO:0006501]; defense response to virus [GO:0051607]; macroautophagy [GO:0016236]; microautophagy [GO:0016237]; positive regulation of autophagy [GO:0010508]; protein localization to phagophore assembly site [GO:0034497]	GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; protein-membrane adaptor activity [GO:0043495]; ubiquitin-like protein transferase activity [GO:0019787]	Atg12-Atg5-Atg16 complex [GO:0034274]; autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; axon [GO:0030424]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endolysosome membrane [GO:0036020]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; phagophore assembly site membrane [GO:0034045]; sperm midpiece [GO:0097225]; vacuole-isolation membrane contact site [GO:0120095]	GO:0000045; GO:0000421; GO:0005737; GO:0005765; GO:0005776; GO:0005829; GO:0005930; GO:0006501; GO:0010008; GO:0010508; GO:0016236; GO:0016237; GO:0019787; GO:0030424; GO:0034045; GO:0034274; GO:0034497; GO:0036020; GO:0042802; GO:0043495; GO:0051020; GO:0051607; GO:0097225; GO:0098930; GO:0098978; GO:0120095
GN021109	GN021109.1	Q8TC12	42.7	288	319	318	2.92e-63	206	RDH11_HUMAN	Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1)	Homo sapiens (Human)	cellular detoxification of aldehyde [GO:0110095]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]	11-cis-retinol dehydrogenase (NADP+) activity [GO:0102354]; aldehyde dehydrogenase (NADP+) activity [GO:0033721]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	endoplasmic reticulum membrane [GO:0005789]; photoreceptor inner segment [GO:0001917]	GO:0001523; GO:0001917; GO:0004745; GO:0005789; GO:0007601; GO:0016616; GO:0033721; GO:0042572; GO:0042574; GO:0052650; GO:0102354; GO:0110095
GN021110	GN021110.1	H3ZPL1	29.6	371	513	417	8.58e-46	168	ARAT1_THELN	Aromatic-amino-acid aminotransferase 1 (ARAT-I) (AROAT) (EC 2.6.1.57)	Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)	alpha-amino acid metabolic process [GO:1901605]	aromatic-amino-acid:2-oxoglutarate transaminase activity [GO:0008793]; pyridoxal phosphate binding [GO:0030170]		GO:0008793; GO:0030170; GO:1901605
GN021111	GN021111.1	Q95KE5	43.1	130	193	159	1.99e-31	114	RM43_BOVIN	Large ribosomal subunit protein mL43 (39S ribosomal protein L43, mitochondrial) (L43mt) (MRP-L43) (Retina-specific 15.7 kDa protein)	Bos taurus (Bovine)	mitochondrial translation [GO:0032543]	structural constituent of ribosome [GO:0003735]	mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]	GO:0003735; GO:0005739; GO:0005743; GO:0005762; GO:0032543
GN021112	GN021112.1	A2BGP7	29.2	346	481	465	1.32e-28	121	CC125_DANRE	Coiled-coil domain-containing protein 125	Danio rerio (Zebrafish) (Brachydanio rerio)	negative regulation of cell motility [GO:2000146]; negative regulation of Rho protein signal transduction [GO:0035024]		cytoplasm [GO:0005737]	GO:0005737; GO:0035024; GO:2000146
GN021113	GN021113.1	Q8C0T1	30.5	636	596	654	5.35e-74	252	FM1AB_MOUSE	Protein fem-1 homolog A-like (FEM1-alpha-B) (Protein fem-1 homolog A-B) (FEM1a-B)	Mus musculus (Mouse)	MAPK cascade [GO:0000165]; negative regulation of inflammatory response [GO:0050728]; positive regulation of inflammatory response [GO:0050729]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the C-end degron rule pathway [GO:0140627]	EP4 subtype prostaglandin E2 receptor binding [GO:0031867]; molecular adaptor activity [GO:0060090]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]	Cul2-RING ubiquitin ligase complex [GO:0031462]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0000165; GO:0005654; GO:0005737; GO:0005739; GO:0005794; GO:0016567; GO:0031462; GO:0031867; GO:0043161; GO:0050728; GO:0050729; GO:0060090; GO:0140627; GO:1990756
GN021114	GN021114.1	Q80UM7	45.0	776	779	834	1.94e-229	666	MOGS_MOUSE	Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Endoplasmic reticulum alpha-glucosidase I) (ER glu I) (Glucosidase 1) (Glycoprotein-processing glucosidase I)	Mus musculus (Mouse)	oligosaccharide metabolic process [GO:0009311]	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [GO:0004573]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]	GO:0004573; GO:0005783; GO:0005789; GO:0009311
GN021115	GN021115.1	Q7ZUV7	38.8	585	1191	1173	3.20e-62	236	EMSY_DANRE	BRCA2-interacting transcriptional repressor EMSY	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of DNA-templated transcription [GO:0006355]		nucleoplasm [GO:0005654]	GO:0005654; GO:0006355
GN021116	GN021116.1	Q7KZN9	59.0	371	511	410	1.28e-149	437	COX15_HUMAN	Heme A synthase COX15 (HAS) (EC 1.17.99.9) (Cytochrome c oxidase assembly protein COX15 homolog)	Homo sapiens (Human)	cytochrome complex assembly [GO:0017004]; heme A biosynthetic process [GO:0006784]; heme biosynthetic process [GO:0006783]	heme A synthase activity [GO:0120547]; heme binding [GO:0020037]; oxidoreductase activity, acting on the CH-CH group of donors [GO:0016627]	cytochrome complex [GO:0070069]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; respiratory chain complex [GO:0098803]	GO:0005739; GO:0005743; GO:0006783; GO:0006784; GO:0016627; GO:0017004; GO:0020037; GO:0070069; GO:0098803; GO:0120547
GN021117	GN021117.1	A6QP16	53.4	656	678	708	1.52e-212	615	ZRAN1_BOVIN	Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (Zinc finger Ran-binding domain-containing protein 1)	Bos taurus (Bovine)	positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway [GO:0030177]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]; protein K63-linked deubiquitination [GO:0070536]	cysteine-type deubiquitinase activity [GO:0004843]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004843; GO:0005634; GO:0005737; GO:0030177; GO:0035523; GO:0070530; GO:0070536; GO:0071947; GO:0090263; GO:1990168
GN021118	GN021118.1	O19071	45.3	360	460	446	8.22e-120	360	MGAT2_PIG	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (GNT-II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II)	Sus scrofa (Pig)	oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation [GO:0006487]	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [GO:0008455]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]	Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]	GO:0000139; GO:0005795; GO:0006487; GO:0008455; GO:0009312; GO:0030145; GO:0042803
GN021119	GN021119.1	Q9P2N6	59.5	449	1047	904	1.15e-175	540	KANL3_HUMAN	KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD)	Homo sapiens (Human)	positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitochondrial transcription [GO:1903108]		histone acetyltransferase complex [GO:0000123]; mitochondrion [GO:0005739]; NSL complex [GO:0044545]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	GO:0000123; GO:0000922; GO:0005634; GO:0005654; GO:0005739; GO:0044545; GO:0045893; GO:0045944; GO:1903108
GN021121	GN021121.1	Q8TC12	39.8	299	306	318	2.99e-59	195	RDH11_HUMAN	Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1)	Homo sapiens (Human)	cellular detoxification of aldehyde [GO:0110095]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]	11-cis-retinol dehydrogenase (NADP+) activity [GO:0102354]; aldehyde dehydrogenase (NADP+) activity [GO:0033721]; all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]	endoplasmic reticulum membrane [GO:0005789]; photoreceptor inner segment [GO:0001917]	GO:0001523; GO:0001917; GO:0004745; GO:0005789; GO:0007601; GO:0016616; GO:0033721; GO:0042572; GO:0042574; GO:0052650; GO:0102354; GO:0110095
GN021123	GN021123.1	B2RW38	59.5	786	865	873	2.99e-248	719	CFA58_MOUSE	Cilia- and flagella-associated protein 58	Mus musculus (Mouse)	cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; Notch signaling pathway [GO:0007219]; protein localization to motile cilium [GO:0120229]; sperm axoneme assembly [GO:0007288]; sperm flagellum assembly [GO:0120316]; sperm mitochondrial sheath assembly [GO:0120317]		centrosome [GO:0005813]; cytoskeleton [GO:0005856]; sperm flagellum [GO:0036126]; sperm midpiece [GO:0097225]; sperm principal piece [GO:0097228]	GO:0005813; GO:0005856; GO:0007219; GO:0007288; GO:0030317; GO:0036126; GO:0060271; GO:0097225; GO:0097228; GO:0120229; GO:0120316; GO:0120317
GN021124	GN021124.1	B8JMH0	39.9	318	343	354	7.16e-68	219	CAF17_DANRE	Iron-sulfur cluster assembly factor IBA57, mitochondrial (Iron-sulfur cluster assembly factor homolog)	Danio rerio (Zebrafish) (Brachydanio rerio)	heme biosynthetic process [GO:0006783]		mitochondrion [GO:0005739]	GO:0005739; GO:0006783
GN021128	GN021128.1	Q695T7	23.2	276	607	634	2.46e-09	63.9	S6A19_HUMAN	Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1)	Homo sapiens (Human)	amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; neurotransmitter transport [GO:0006836]; neutral amino acid transport [GO:0015804]; response to nutrient [GO:0007584]; sodium ion transmembrane transport [GO:0035725]; viral life cycle [GO:0019058]	alanine:sodium symporter activity [GO:0015655]; amino acid transmembrane transporter activity [GO:0015171]; glycine:sodium symporter activity [GO:0015375]; neutral L-amino acid transmembrane transporter activity [GO:0015175]	apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]	GO:0005886; GO:0006836; GO:0006865; GO:0007584; GO:0015171; GO:0015175; GO:0015375; GO:0015655; GO:0015804; GO:0016324; GO:0019058; GO:0031526; GO:0035725; GO:0070062; GO:0089718; GO:1902495
GN021129	GN021129.1	Q6NZN1	54.1	122	637	1644	9.73e-33	139	PPRC1_MOUSE	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC)	Mus musculus (Mouse)	energy homeostasis [GO:0097009]; positive regulation of transcription by RNA polymerase II [GO:0045944]	RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003713; GO:0003723; GO:0005634; GO:0005654; GO:0045944; GO:0097009
GN021130	GN021130.1	Q9Y3B2	59.0	195	197	195	3.63e-74	224	EXOS1_HUMAN	Exosome complex component CSL4 (Exosome component 1)	Homo sapiens (Human)	RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolar exosome (RNase complex) [GO:0101019]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000176; GO:0000177; GO:0000178; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006396; GO:0006401; GO:0101019
GN021131	GN021131.1	Q8BP78	52.7	315	300	315	3.93e-96	289	F10C1_MOUSE	Protein FRA10AC1 homolog	Mus musculus (Mouse)	mRNA splicing, via spliceosome [GO:0000398]		nucleus [GO:0005634]	GO:0000398; GO:0005634
GN021132	GN021132.1	Q04743	72.0	82	256	252	7.59e-28	110	EMX2_HUMAN	Homeobox protein EMX2 (Empty spiracles homolog 2) (Empty spiracles-like protein 2)	Homo sapiens (Human)	brain development [GO:0007420]; central nervous system development [GO:0007417]; neuron differentiation [GO:0030182]; regulation of transcription by RNA polymerase II [GO:0006357]; stereocilium bundle organization [GO:0160194]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]	axon [GO:0030424]; chromatin [GO:0000785]; nucleus [GO:0005634]	GO:0000785; GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0007417; GO:0007420; GO:0030182; GO:0030424; GO:0160194; GO:1990837
GN021133	GN021133.1	Q6TXG9	42.2	90	306	251	1.20e-11	67.0	SFR1_RAT	Swi5-dependent recombination DNA repair protein 1 homolog (Liver regeneration-related protein LRRGT00030) (Meiosis protein 5 homolog)	Rattus norvegicus (Rat)	cellular response to estrogen stimulus [GO:0071391]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of DNA-templated transcription [GO:0045893]	transcription coactivator activity [GO:0003713]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Swi5-Sfr1 complex [GO:0032798]	GO:0000724; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0032798; GO:0045893; GO:0071391
GN021134	GN021134.1	Q6PGW3	57.1	693	694	689	4.67e-272	766	ARMD3_DANRE	Armadillo-like helical domain-containing protein 3	Danio rerio (Zebrafish) (Brachydanio rerio)	regulation of Golgi organization [GO:1903358]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005737; GO:0005829; GO:1903358
GN021135	GN021135.1	Q0D2E8	48.4	479	631	539	1.09e-153	456	RFT1_XENTR	Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 (Protein RFT1 homolog)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; glycolipid translocation [GO:0034203]; protein N-linked glycosylation [GO:0006487]		endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0006487; GO:0006488; GO:0034203
GN021136	GN021136.1	Q5ZJK8	79.1	541	548	553	3.43e-310	851	TCPH_CHICK	T-complex protein 1 subunit eta (TCP-1-eta) (EC 3.6.1.-) (CCT-eta)	Gallus gallus (Chicken)	protein folding [GO:0006457]	ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent protein folding chaperone [GO:0140662]	chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]	GO:0005524; GO:0005737; GO:0005832; GO:0006457; GO:0016887; GO:0140662
GN021138	GN021138.1	P18488	53.8	130	316	494	4.81e-29	119	EMS_DROME	Homeotic protein empty spiracles	Drosophila melanogaster (Fruit fly)	anterior head segmentation [GO:0035288]; axonogenesis [GO:0007409]; brain development [GO:0007420]; brain segmentation [GO:0035284]; cell differentiation [GO:0030154]; dendrite morphogenesis [GO:0048813]; embryonic development via the syncytial blastoderm [GO:0001700]; neuroblast development [GO:0014019]; open tracheal system development [GO:0007424]; pattern specification process [GO:0007389]; regulation of gene expression [GO:0010468]; regulation of transcription by RNA polymerase II [GO:0006357]; spiracle morphogenesis, open tracheal system [GO:0035277]; ventral cord development [GO:0007419]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]	nucleus [GO:0005634]	GO:0000977; GO:0000978; GO:0000981; GO:0001700; GO:0005634; GO:0006357; GO:0007389; GO:0007409; GO:0007419; GO:0007420; GO:0007424; GO:0010468; GO:0014019; GO:0030154; GO:0035277; GO:0035284; GO:0035288; GO:0048813
GN021139	GN021139.1	A0A0B7P9G0	46.9	683	814	834	7.23e-187	558	UEX_DROME	Unextended protein (Putative metal transporter uex)	Drosophila melanogaster (Fruit fly)	cellular response to carbon dioxide [GO:0071244]; export across plasma membrane [GO:0140115]; intracellular monoatomic ion homeostasis [GO:0006873]; long-term memory [GO:0007616]; magnesium ion homeostasis [GO:0010960]; magnesium ion transmembrane transport [GO:1903830]	magnesium ion transmembrane transporter activity [GO:0015095]; transmembrane transporter activity [GO:0022857]	plasma membrane [GO:0005886]	GO:0005886; GO:0006873; GO:0007616; GO:0010960; GO:0015095; GO:0022857; GO:0071244; GO:0140115; GO:1903830
GN021143	GN021143.1	Q27245	46.3	518	515	522	1.24e-147	436	YH24_CAEEL	Putative aminopeptidase W07G4.4 (EC 3.4.11.-)	Caenorhabditis elegans	proteolysis [GO:0006508]	manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]	cytoplasm [GO:0005737]	GO:0005737; GO:0006508; GO:0030145; GO:0070006
GN021144	GN021144.1	Q6GLT8	56.6	290	288	319	8.36e-123	356	FAHD2_XENLA	Oxaloacetate tautomerase fahd2, mitochondrial (EC 5.3.2.2) (Fumarylacetoacetate hydrolase domain-containing protein 2)	Xenopus laevis (African clawed frog)	oxaloacetate metabolic process [GO:0006107]	oxaloacetate tautomerase activity [GO:0050163]	mitochondrion [GO:0005739]	GO:0005739; GO:0006107; GO:0050163
GN021146	GN021146.1	P15153	71.7	191	195	192	1.77e-101	293	RAC2_HUMAN	Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2)	Homo sapiens (Human)	actin filament organization [GO:0007015]; bone resorption [GO:0045453]; chemotaxis [GO:0006935]; establishment or maintenance of cell polarity [GO:0007163]; lymphocyte aggregation [GO:0071593]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein localization to mitochondrion [GO:1903749]; regulation of cell shape [GO:0008360]; regulation of cell-substrate adhesion [GO:0010810]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mast cell chemotaxis [GO:0060753]; regulation of mast cell degranulation [GO:0043304]; regulation of neutrophil migration [GO:1902622]; regulation of respiratory burst [GO:0060263]; regulation of T cell proliferation [GO:0042129]; respiratory burst [GO:0045730]; signal transduction [GO:0007165]; small GTPase-mediated signal transduction [GO:0007264]; superoxide anion generation [GO:0042554]	G protein activity [GO:0003925]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase regulator activity [GO:0019887]	cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mitochondrial outer membrane [GO:0005741]; NADPH oxidase complex [GO:0043020]; nuclear envelope [GO:0005635]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]	GO:0003924; GO:0003925; GO:0005525; GO:0005635; GO:0005741; GO:0005789; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0006935; GO:0007015; GO:0007163; GO:0007165; GO:0007264; GO:0008360; GO:0010310; GO:0010592; GO:0010810; GO:0019887; GO:0030027; GO:0030670; GO:0031410; GO:0042129; GO:0042554; GO:0043020; GO:0043304; GO:0045453; GO:0045730; GO:0060263; GO:0060753; GO:0070062; GO:0071593; GO:0090023; GO:1902622; GO:1903749
GN021147	GN021147.1	P04464	29.2	137	199	149	9.05e-10	58.2	CALM_WHEAT	Calmodulin (CaM)	Triticum aestivum (Wheat)		calcium ion binding [GO:0005509]; enzyme regulator activity [GO:0030234]; protein domain specific binding [GO:0019904]	cytoplasm [GO:0005737]	GO:0005509; GO:0005737; GO:0019904; GO:0030234
GN021150	GN021150.1	Q96RW7	36.4	110	434	5635	6.76e-11	68.6	HMCN1_HUMAN	Hemicentin-1 (Fibulin-6) (FIBL-6)	Homo sapiens (Human)	actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]	calcium ion binding [GO:0005509]; cell adhesion mediator activity [GO:0098631]; extracellular matrix structural constituent [GO:0005201]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; muscle tendon junction [GO:0005927]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005886; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0030036; GO:0031012; GO:0032154; GO:0070062; GO:0070161; GO:0071711; GO:0098631; GO:0140144
GN021151	GN021151.1	Q9Z0P7	55.4	435	429	484	2.45e-169	486	SUFU_MOUSE	Suppressor of fused homolog	Mus musculus (Mouse)	aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; determination of left/right symmetry [GO:0007368]; heart looping [GO:0001947]; maintenance of protein localization in organelle [GO:0072595]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural tube closure [GO:0001843]; positive regulation of cellular response to drug [GO:2001040]; positive regulation of protein processing [GO:0010954]; regulation of DNA-templated transcription [GO:0006355]; skin development [GO:0043588]; smoothened signaling pathway [GO:0007224]; spermatid development [GO:0007286]; spinal cord dorsal/ventral patterning [GO:0021513]; ventricular septum development [GO:0003281]	beta-catenin binding [GO:0008013]; protein kinase binding [GO:0019901]; protein sequestering activity [GO:0140311]; protein-macromolecule adaptor activity [GO:0030674]	cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GLI-SUFU complex [GO:1990788]; non-motile cilium [GO:0097730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0001843; GO:0001947; GO:0003281; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005929; GO:0006355; GO:0007224; GO:0007286; GO:0007368; GO:0008013; GO:0010954; GO:0019901; GO:0021513; GO:0030674; GO:0035904; GO:0043588; GO:0045879; GO:0060976; GO:0072595; GO:0097730; GO:0140311; GO:1990788; GO:2000059; GO:2001040
GN021156	GN021156.1	Q9DAM9	34.7	291	348	344	3.46e-53	181	FANK1_MOUSE	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell-specific gene 1 protein) (GSG1)	Mus musculus (Mouse)	negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-templated transcription [GO:0045893]		chromatin [GO:0000785]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000785; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005929; GO:0036064; GO:0043065; GO:0043066; GO:0045893; GO:0097546
GN021157	GN021157.1	Q0IHY4	67.7	124	137	684	2.70e-51	175	TBC12_XENTR	TBC1 domain family member 12	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	vesicle-mediated transport [GO:0016192]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytoplasmic vesicle [GO:0031410]; vacuole [GO:0005773]	GO:0005096; GO:0005773; GO:0016192; GO:0031267; GO:0031410
GN021158	GN021158.1	Q0IHY4	48.7	76	89	684	6.54e-22	91.3	TBC12_XENTR	TBC1 domain family member 12	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	vesicle-mediated transport [GO:0016192]	GTPase activator activity [GO:0005096]; small GTPase binding [GO:0031267]	cytoplasmic vesicle [GO:0031410]; vacuole [GO:0005773]	GO:0005096; GO:0005773; GO:0016192; GO:0031267; GO:0031410
GN021159	GN021159.1	M0R7T9	39.0	123	145	693	5.81e-15	73.9	TBC12_RAT	TBC1 domain family member 12	Rattus norvegicus (Rat)	regulation of autophagosome assembly [GO:2000785]; vesicle-mediated transport [GO:0016192]	enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]	autophagosome [GO:0005776]; endosome [GO:0005768]; recycling endosome [GO:0055037]	GO:0005096; GO:0005768; GO:0005776; GO:0016192; GO:0019899; GO:0055037; GO:2000785
GN021160	GN021160.1	Q7ZUN8	61.5	187	195	198	4.81e-77	232	YKT6_DANRE	Synaptobrevin homolog YKT6 (EC 2.3.1.-)	Danio rerio (Zebrafish) (Brachydanio rerio)		SNAP receptor activity [GO:0005484]	cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005484; GO:0005794; GO:0005829; GO:0030659
GN021163	GN021163.1	Q5ZKN5	31.1	331	401	418	7.42e-13	73.2	FA53A_CHICK	Protein FAM53A (Dorsal neural-tube nuclear protein)	Gallus gallus (Chicken)	protein import into nucleus [GO:0006606]		nucleus [GO:0005634]	GO:0005634; GO:0006606
GN021164	GN021164.1	P25931	28.7	324	348	464	1.71e-27	115	RYAR_DROME	RYamide receptor (Neuropeptide Y-like receptor) (NPY-R)	Drosophila melanogaster (Fruit fly)	G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]	neuropeptide receptor activity [GO:0008188]; neuropeptide Y receptor activity [GO:0004983]; peptide receptor activity [GO:0001653]	membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0001653; GO:0004983; GO:0005886; GO:0007186; GO:0007218; GO:0008188; GO:0016020
GN021165	GN021165.1	Q9SKB3	41.2	250	1344	548	1.16e-41	165	PARG1_ARATH	Poly(ADP-ribose) glycohydrolase 1 (EC 3.2.1.143)	Arabidopsis thaliana (Mouse-ear cress)	ATP generation from poly-ADP-D-ribose [GO:1990966]; carbohydrate metabolic process [GO:0005975]; defense response to fungus [GO:0050832]; DNA damage response [GO:0006974]; nucleotide-sugar metabolic process [GO:0009225]; regulation of DNA repair [GO:0006282]; response to osmotic stress [GO:0006970]; response to oxidative stress [GO:0006979]; response to water deprivation [GO:0009414]; stomatal closure [GO:0090332]	poly(ADP-ribose) glycohydrolase activity [GO:0004649]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004649; GO:0005634; GO:0005737; GO:0005975; GO:0006282; GO:0006970; GO:0006974; GO:0006979; GO:0009225; GO:0009414; GO:0050832; GO:0090332; GO:1990966
GN021166	GN021166.1	O60347	39.3	242	545	775	3.13e-43	167	TBC12_HUMAN	TBC1 domain family member 12	Homo sapiens (Human)	regulation of autophagosome assembly [GO:2000785]; vesicle-mediated transport [GO:0016192]	enzyme binding [GO:0019899]; GTPase activator activity [GO:0005096]	autophagosome [GO:0005776]; endosome [GO:0005768]; recycling endosome [GO:0055037]	GO:0005096; GO:0005768; GO:0005776; GO:0016192; GO:0019899; GO:0055037; GO:2000785
GN021172	GN021172.1	P08154	88.7	62	563	508	4.00e-26	115	EGR1_RAT	Early growth response protein 1 (EGR-1) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor Zif268) (Zinc finger protein Krox-24)	Rattus norvegicus (Rat)	BMP signaling pathway [GO:0030509]; cellular response to antibiotic [GO:0071236]; cellular response to cAMP [GO:0071320]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to gamma radiation [GO:0071480]; cellular response to gonadotropin stimulus [GO:0071371]; cellular response to growth factor stimulus [GO:0071363]; cellular response to heparin [GO:0071504]; cellular response to hyperoxia [GO:0071455]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-8 [GO:0098759]; cellular response to isoquinoline alkaloid [GO:0071317]; cellular response to mechanical stimulus [GO:0071260]; cellular response to mycophenolic acid [GO:0071506]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to xenobiotic stimulus [GO:0071466]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; circadian temperature homeostasis [GO:0060086]; estrous cycle [GO:0044849]; glomerular mesangial cell proliferation [GO:0072110]; interleukin-1-mediated signaling pathway [GO:0070498]; learning or memory [GO:0007611]; locomotor rhythm [GO:0045475]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oligodendrocyte differentiation [GO:0048709]; positive regulation of chemokine production [GO:0032722]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; positive regulation of gene expression via chromosomal CpG island demethylation [GO:0044029]; positive regulation of glomerular metanephric mesangial cell proliferation [GO:0072303]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of post-translational protein modification [GO:1901875]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of DNA-templated transcription [GO:0006355]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of progesterone biosynthetic process [GO:2000182]; regulation of protein sumoylation [GO:0033233]; regulation of transcription by RNA polymerase II [GO:0006357]; response to amphetamine [GO:0001975]; response to carbon monoxide [GO:0034465]; response to cocaine [GO:0042220]; response to electrical stimulus [GO:0051602]; response to ethanol [GO:0045471]; response to follicle-stimulating hormone [GO:0032354]; response to glucose [GO:0009749]; response to gonadotropin [GO:0034698]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to ischemia [GO:0002931]; response to morphine [GO:0043278]; response to norepinephrine [GO:0071873]; response to nutrient levels [GO:0031667]; response to xenobiotic stimulus [GO:0009410]; skeletal muscle cell differentiation [GO:0035914]; T cell differentiation [GO:0030217]	DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; double-stranded methylated DNA binding [GO:0010385]; enzyme binding [GO:0019899]; hemi-methylated DNA-binding [GO:0044729]; histone acetyltransferase binding [GO:0035035]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000785; GO:0000976; GO:0000977; GO:0000978; GO:0000979; GO:0000981; GO:0001228; GO:0001666; GO:0001975; GO:0002931; GO:0003677; GO:0003690; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006355; GO:0006357; GO:0007611; GO:0007616; GO:0007623; GO:0008270; GO:0009410; GO:0009749; GO:0010385; GO:0010628; GO:0014911; GO:0019899; GO:0030217; GO:0030509; GO:0031667; GO:0032354; GO:0032722; GO:0032731; GO:0032868; GO:0032869; GO:0032922; GO:0033233; GO:0034465; GO:0034698; GO:0035035; GO:0035914; GO:0042220; GO:0042981; GO:0043278; GO:0043525; GO:0043565; GO:0044029; GO:0044729; GO:0044849; GO:0045471; GO:0045475; GO:0045893; GO:0045944; GO:0046886; GO:0048169; GO:0048661; GO:0048709; GO:0051602; GO:0060086; GO:0060291; GO:0070498; GO:0071236; GO:0071260; GO:0071317; GO:0071320; GO:0071363; GO:0071371; GO:0071372; GO:0071383; GO:0071455; GO:0071456; GO:0071466; GO:0071480; GO:0071504; GO:0071506; GO:0071873; GO:0072110; GO:0072303; GO:0090090; GO:0098759; GO:1901875; GO:1902895; GO:1990837; GO:1990841; GO:2000182
GN021175	GN021175.1	Q9DE46	55.2	1444	1445	1458	0.0	1439	DPOLA_XENLA	DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180)	Xenopus laevis (African clawed frog)	DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of primer [GO:0006269]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair via nonhomologous end joining [GO:0006303]; lagging strand elongation [GO:0006273]; leading strand elongation [GO:0006272]; mitotic DNA replication initiation [GO:1902975]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA replication origin binding [GO:0003688]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166]; single-stranded DNA binding [GO:0003697]	alpha DNA polymerase:primase complex [GO:0005658]; chromatin [GO:0000785]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000166; GO:0000731; GO:0000785; GO:0003677; GO:0003682; GO:0003688; GO:0003697; GO:0003887; GO:0005634; GO:0005635; GO:0005654; GO:0005658; GO:0005730; GO:0006260; GO:0006269; GO:0006270; GO:0006271; GO:0006272; GO:0006273; GO:0006303; GO:0016363; GO:1902975
GN021176	GN021176.1	Q5TEA3	56.0	141	156	1177	3.30e-49	172	DAAF9_HUMAN	Dynein axonemal assembly factor 9 (DNAAF9) (Shulin)	Homo sapiens (Human)				
GN021177	GN021177.1	Q4VBI7	44.7	244	303	314	3.35e-49	169	STX18_DANRE	Syntaxin-18	Danio rerio (Zebrafish) (Brachydanio rerio)	intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [GO:0006890]	SNAP receptor activity [GO:0005484]	endoplasmic reticulum membrane [GO:0005789]; SNARE complex [GO:0031201]	GO:0005484; GO:0005789; GO:0006886; GO:0006890; GO:0031201
GN021178	GN021178.1	Q96DM1	25.8	384	482	585	3.37e-31	130	PGBD4_HUMAN	PiggyBac transposable element-derived protein 4	Homo sapiens (Human)				
GN021179	GN021179.1	Q92113	34.5	487	499	509	1.62e-88	283	CP17A_SQUAC	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)	Squalus acanthias (Spiny dogfish)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid biosynthetic process [GO:0006694]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	membrane [GO:0016020]	GO:0004508; GO:0005506; GO:0006694; GO:0016020; GO:0020037; GO:0042446; GO:0042448
GN021180	GN021180.1	Q92113	35.0	471	567	509	8.75e-91	291	CP17A_SQUAC	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)	Squalus acanthias (Spiny dogfish)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid biosynthetic process [GO:0006694]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	membrane [GO:0016020]	GO:0004508; GO:0005506; GO:0006694; GO:0016020; GO:0020037; GO:0042446; GO:0042448
GN021182	GN021182.1	Q92113	34.2	473	498	509	1.33e-82	268	CP17A_SQUAC	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)	Squalus acanthias (Spiny dogfish)	hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; steroid biosynthetic process [GO:0006694]	heme binding [GO:0020037]; iron ion binding [GO:0005506]; steroid 17-alpha-monooxygenase activity [GO:0004508]	membrane [GO:0016020]	GO:0004508; GO:0005506; GO:0006694; GO:0016020; GO:0020037; GO:0042446; GO:0042448
GN021184	GN021184.1	Q14315	24.3	1504	1397	2725	2.60e-91	331	FLNC_HUMAN	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Homo sapiens (Human)	sarcomere organization [GO:0045214]	actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]	costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018]	GO:0005737; GO:0005829; GO:0005856; GO:0005925; GO:0008092; GO:0016528; GO:0030018; GO:0030506; GO:0042383; GO:0042802; GO:0043034; GO:0045214; GO:0051015
GN021186	GN021186.1	Q14315	26.1	628	696	2725	4.00e-44	175	FLNC_HUMAN	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Homo sapiens (Human)	sarcomere organization [GO:0045214]	actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]	costamere [GO:0043034]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018]	GO:0005737; GO:0005829; GO:0005856; GO:0005925; GO:0008092; GO:0016528; GO:0030018; GO:0030506; GO:0042383; GO:0042802; GO:0043034; GO:0045214; GO:0051015
GN021191	GN021191.1	F4HYF3	42.3	350	375	401	5.17e-92	284	DCYD1_ARATH	Bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial (EC 3.5.99.7) (EC 4.4.1.15) (1-aminocyclopropane-1-carboxylic acid deaminase 1) (AtACD1) (AtD-CDes1) (D-CDes1) (D-CDES)	Arabidopsis thaliana (Mouse-ear cress)	ethylene biosynthetic process [GO:0009693]; stress response to cadmium ion [GO:1990170]	cobalt ion binding [GO:0050897]; D-cysteine desulfhydrase activity [GO:0019148]	chloroplast [GO:0009507]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0005634; GO:0005739; GO:0005829; GO:0009507; GO:0009693; GO:0019148; GO:0050897; GO:1990170
GN021194	GN021194.1	Q8C436	50.5	210	214	228	1.16e-67	210	MT21D_MOUSE	Protein N-lysine methyltransferase METTL21D (EC 2.1.1.-) (Methyltransferase-like protein 21D) (VCP lysine methyltransferase) (VCP-KMT) (Valosin-containing protein lysine methyltransferase)	Mus musculus (Mouse)	negative regulation of ATP-dependent activity [GO:0032780]; peptidyl-lysine methylation [GO:0018022]; peptidyl-lysine trimethylation [GO:0018023]	ATPase binding [GO:0051117]; protein methyltransferase activity [GO:0008276]; protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular protein-containing complex [GO:0140535]; protein-containing complex [GO:0032991]	GO:0005737; GO:0005829; GO:0008276; GO:0016279; GO:0018022; GO:0018023; GO:0032780; GO:0032991; GO:0051117; GO:0140535
GN021196	GN021196.1	P21333	28.3	1153	1128	2647	3.60e-99	350	FLNA_HUMAN	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Homo sapiens (Human)	actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; blood coagulation, intrinsic pathway [GO:0007597]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0060271]; establishment of protein localization [GO:0045184]; establishment of Sertoli cell barrier [GO:0097368]; formation of radial glial scaffolds [GO:0021943]; megakaryocyte development [GO:0035855]; mitotic spindle assembly [GO:0090307]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by RNA polymerase I [GO:0016479]; platelet aggregation [GO:0070527]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neuron migration [GO:2001224]; positive regulation of platelet activation [GO:0010572]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to bicellular tight junction [GO:1902396]; protein localization to cell surface [GO:0034394]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of cell migration [GO:0030334]; regulation of membrane repolarization during atrial cardiac muscle cell action potential [GO:1905000]; regulation of membrane repolarization during cardiac muscle cell action potential [GO:1905031]; release of sequestered calcium ion into cytosol [GO:0051209]; semaphorin-plexin signaling pathway [GO:0071526]; tubulin deacetylation [GO:0090042]; wound healing, spreading of cells [GO:0044319]	actin filament binding [GO:0051015]; cadherin binding [GO:0045296]; DNA-binding transcription factor binding [GO:0140297]; Fc-gamma receptor I complex binding [GO:0034988]; G protein-coupled receptor binding [GO:0001664]; GTPase binding [GO:0051020]; kinase binding [GO:0019900]; potassium channel regulator activity [GO:0015459]; protein homodimerization activity [GO:0042803]; protein sequestering activity [GO:0140311]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]; small GTPase binding [GO:0031267]; transmembrane transporter binding [GO:0044325]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; apical dendrite [GO:0097440]; cell-cell junction [GO:0005911]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic shaft [GO:0043198]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; glycoprotein Ib-IX-V complex [GO:1990779]; growth cone [GO:0030426]; membrane [GO:0016020]; Myb complex [GO:0031523]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynapse [GO:0098794]; Z disc [GO:0030018]	GO:0001664; GO:0002102; GO:0003723; GO:0005576; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005884; GO:0005886; GO:0005911; GO:0005925; GO:0007195; GO:0007597; GO:0010572; GO:0015459; GO:0015629; GO:0016020; GO:0016479; GO:0019900; GO:0021943; GO:0021987; GO:0030018; GO:0030036; GO:0030334; GO:0030426; GO:0030863; GO:0031267; GO:0031523; GO:0032233; GO:0034394; GO:0034988; GO:0035855; GO:0042177; GO:0042307; GO:0042789; GO:0042803; GO:0043066; GO:0043113; GO:0043123; GO:0043198; GO:0043204; GO:0044319; GO:0044325; GO:0045184; GO:0045296; GO:0046332; GO:0048471; GO:0050821; GO:0051015; GO:0051020; GO:0051209; GO:0051764; GO:0060271; GO:0070062; GO:0070527; GO:0071526; GO:0072659; GO:0090042; GO:0090307; GO:0097368; GO:0097440; GO:0098794; GO:0098978; GO:0140297; GO:0140311; GO:1900026; GO:1901381; GO:1902396; GO:1905000; GO:1905031; GO:1990779; GO:2000179; GO:2001046; GO:2001224
GN021197	GN021197.1	Q29R99	51.6	223	255	224	1.03e-80	244	LIPT2_DANRE	Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial (Lipoate-protein ligase B) (Lipoyl/octanoyl transferase) (Lipoyltransferase 2) (EC 2.3.1.181) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase)	Danio rerio (Zebrafish) (Brachydanio rerio)	protein lipoylation [GO:0009249]	lipoyl(octanoyl) transferase activity [GO:0033819]	mitochondrion [GO:0005739]	GO:0005739; GO:0009249; GO:0033819
GN021200	GN021200.1	Q2KHS5	53.9	230	231	335	2.61e-85	259	MOG2A_XENLA	2-acylglycerol O-acyltransferase 2-A (EC 2.3.1.20) (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 2-A) (MGAT2-A) (Monoacylglycerol O-acyltransferase 2-A)	Xenopus laevis (African clawed frog)	diacylglycerol biosynthetic process [GO:0006651]; monoacylglycerol biosynthetic process [GO:0006640]; triglyceride biosynthetic process [GO:0019432]	2-acylglycerol O-acyltransferase activity [GO:0003846]; diacylglycerol O-acyltransferase activity [GO:0004144]	perinuclear endoplasmic reticulum membrane [GO:1990578]	GO:0003846; GO:0004144; GO:0006640; GO:0006651; GO:0019432; GO:1990578
GN021202	GN021202.1	Q9UGH3	32.9	562	691	650	2.22e-105	337	S23A2_HUMAN	Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2)	Homo sapiens (Human)	cellular response to ethanol [GO:0071361]; L-ascorbic acid metabolic process [GO:0019852]; L-ascorbic acid transmembrane transport [GO:0015882]; positive regulation of dendrite extension [GO:1903861]; response to oxidative stress [GO:0006979]	L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886; GO:0006979; GO:0008520; GO:0015229; GO:0015882; GO:0016020; GO:0016323; GO:0016324; GO:0019852; GO:0071361; GO:1903861
GN021203	GN021203.1	Q6P2D8	29.4	887	892	792	4.61e-78	273	XRRA1_HUMAN	X-ray radiation resistance-associated protein 1	Homo sapiens (Human)	response to X-ray [GO:0010165]		cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0010165; GO:0016604
GN021204	GN021204.1	Q8IPW2	41.2	422	412	548	4.17e-93	293	NCK_DROME	SH2/SH3 adapter protein dreadlocks	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; myoblast fusion [GO:0007520]; negative regulation of insulin receptor signaling pathway [GO:0046627]; photoreceptor cell axon guidance [GO:0072499]	cell adhesion molecule binding [GO:0050839]; insulin receptor binding [GO:0005158]; kinase binding [GO:0019900]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]	cell periphery [GO:0071944]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; growth cone [GO:0030426]; male germline ring canal [GO:0035323]; nuclear body [GO:0016604]; perikaryon [GO:0043204]	GO:0005158; GO:0005829; GO:0007411; GO:0007520; GO:0016604; GO:0019900; GO:0019901; GO:0030136; GO:0030426; GO:0030674; GO:0035323; GO:0043204; GO:0046627; GO:0050839; GO:0071944; GO:0072499
GN021216	GN021216.1	Q9Y251	55.5	110	112	543	3.28e-30	115	HPSE_HUMAN	Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]	Homo sapiens (Human)	angiogenesis involved in wound healing [GO:0060055]; cell-matrix adhesion [GO:0007160]; establishment of endothelial barrier [GO:0061028]; heparan sulfate proteoglycan catabolic process [GO:0030200]; heparin proteoglycan metabolic process [GO:0030202]; positive regulation of blood coagulation [GO:0030194]; positive regulation of hair follicle development [GO:0051798]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein transmembrane transport [GO:0071806]; proteoglycan metabolic process [GO:0006029]; regulation of hair follicle development [GO:0051797]; response to antibiotic [GO:0046677]; vascular wound healing [GO:0061042]	beta-glucuronidase activity [GO:0004566]; heparanase activity [GO:0030305]; syndecan binding [GO:0045545]	extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; specific granule lumen [GO:0035580]	GO:0004566; GO:0005576; GO:0005634; GO:0005654; GO:0005764; GO:0005765; GO:0005886; GO:0006029; GO:0007160; GO:0010575; GO:0030194; GO:0030200; GO:0030202; GO:0030305; GO:0031012; GO:0033690; GO:0035580; GO:0043202; GO:0045121; GO:0045545; GO:0046677; GO:0051797; GO:0051798; GO:0051897; GO:0060055; GO:0061028; GO:0061042; GO:0071806
GN021219	GN021219.1	P22807	71.3	115	284	659	9.08e-40	149	SLOU_DROME	Homeobox protein slou (Homeobox protein NK-1) (Protein slouch) (S59/2)	Drosophila melanogaster (Fruit fly)	cell differentiation [GO:0030154]; muscle cell fate determination [GO:0007521]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0007517; GO:0007521; GO:0030154
GN021222	GN021222.1	P22807	71.3	115	172	659	2.34e-41	149	SLOU_DROME	Homeobox protein slou (Homeobox protein NK-1) (Protein slouch) (S59/2)	Drosophila melanogaster (Fruit fly)	cell differentiation [GO:0030154]; muscle cell fate determination [GO:0007521]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	nucleus [GO:0005634]	GO:0000122; GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0007517; GO:0007521; GO:0030154
GN021223	GN021223.1	P20905	43.9	371	483	564	1.78e-82	268	5HT1R_DROME	5-hydroxytryptamine receptor 1 (5-HT receptor) (5HT-dro) (Serotonin receptor 1)	Drosophila melanogaster (Fruit fly)	adenylate cyclase-activating serotonin receptor signaling pathway [GO:0007192]; chemical synaptic transmission [GO:0007268]; courtship behavior [GO:0007619]; female mating behavior [GO:0060180]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; male courtship behavior, orientation prior to leg tapping and wing vibration [GO:0016543]; male courtship behavior, proboscis-mediated licking [GO:0016546]; male courtship behavior, veined wing vibration [GO:0016545]; male mating behavior [GO:0060179]; serotonin receptor signaling pathway [GO:0007210]	G protein-coupled amine receptor activity [GO:0008227]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]	dendrite [GO:0030425]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0004993; GO:0005886; GO:0007187; GO:0007192; GO:0007210; GO:0007268; GO:0007619; GO:0008227; GO:0016020; GO:0016543; GO:0016545; GO:0016546; GO:0030425; GO:0030594; GO:0045202; GO:0060179; GO:0060180
GN021227	GN021227.1	P11979	37.3	142	151	531	7.64e-27	107	KPYM_FELCA	Pyruvate kinase PKM (EC 2.7.1.40) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2)	Felis catus (Cat) (Felis silvestris catus)	cellular response to insulin stimulus [GO:0032869]; glycolytic process [GO:0006096]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of sprouting angiogenesis [GO:1903672]	magnesium ion binding [GO:0000287]; mRNA binding [GO:0003729]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; potassium ion binding [GO:0030955]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; pyruvate kinase activity [GO:0004743]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; rough endoplasmic reticulum [GO:0005791]	GO:0000287; GO:0003729; GO:0004674; GO:0004713; GO:0004715; GO:0004743; GO:0005634; GO:0005737; GO:0005791; GO:0006096; GO:0030955; GO:0032869; GO:1903672; GO:2000767
GN021228	GN021228.1	O62619	54.0	200	225	533	2.28e-67	219	KPYK_DROME	Pyruvate kinase (PK) (EC 2.7.1.40)	Drosophila melanogaster (Fruit fly)	canonical glycolysis [GO:0061621]; glucose homeostasis [GO:0042593]; glycolytic process [GO:0006096]; pyruvate biosynthetic process [GO:0042866]; response to sucrose [GO:0009744]	magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743]	cytosol [GO:0005829]; mitochondrion [GO:0005739]; P granule [GO:0043186]	GO:0000287; GO:0004743; GO:0005739; GO:0005829; GO:0006096; GO:0009744; GO:0030955; GO:0042593; GO:0042866; GO:0043186; GO:0061621
GN021229	GN021229.1	Q5EAY8	59.8	405	596	546	3.15e-162	477	TAPT1_XENLA	Transmembrane anterior posterior transformation protein 1 homolog	Xenopus laevis (African clawed frog)	neural crest cell development [GO:0014032]; positive regulation of bone development [GO:1903012]; positive regulation of cartilage development [GO:0061036]; positive regulation of cilium assembly [GO:0045724]		centrosome [GO:0005813]; ciliary basal body [GO:0036064]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]	GO:0005789; GO:0005813; GO:0014032; GO:0016020; GO:0036064; GO:0045724; GO:0061036; GO:1903012
GN021230	GN021230.1	Q6NZC7	48.6	743	1052	998	1.78e-226	674	S23IP_MOUSE	SEC23-interacting protein	Mus musculus (Mouse)	acrosome assembly [GO:0001675]; single fertilization [GO:0007338]; spermatid development [GO:0007286]	glycerophospholipase activity [GO:0004620]; metal ion binding [GO:0046872]	cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum exit site [GO:0070971]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; perinuclear endoplasmic reticulum [GO:0097038]; perinuclear region of cytoplasm [GO:0048471]	GO:0001675; GO:0004620; GO:0005794; GO:0005801; GO:0007286; GO:0007338; GO:0012507; GO:0030134; GO:0046872; GO:0048471; GO:0070971; GO:0097038
GN021232	GN021232.1	Q7RTY0	25.5	400	459	426	2.69e-34	136	MOT13_HUMAN	Monocarboxylate transporter 13 (MCT 13) (Solute carrier family 16 member 13)	Homo sapiens (Human)		monocarboxylic acid transmembrane transporter activity [GO:0008028]	Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]	GO:0000139; GO:0005794; GO:0005886; GO:0008028
GN021233	GN021233.1	Q6GM59	25.6	410	488	460	1.15e-35	141	MOT12_XENLA	Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12)	Xenopus laevis (African clawed frog)	creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]	creatine transmembrane transporter activity [GO:0005308]; transmembrane transporter activity [GO:0022857]; uniporter activity [GO:0015292]	basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]	GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0022857; GO:0046449
GN021234	GN021234.1	Q8IZJ3	35.0	120	312	1885	1.03e-12	72.4	CPMD8_HUMAN	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8	Homo sapiens (Human)	eye development [GO:0001654]	endopeptidase inhibitor activity [GO:0004866]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0001654; GO:0004866; GO:0005576; GO:0005886
GN021237	GN021237.1	Q8CGN4	41.5	258	1694	1759	4.86e-22	108	BCOR_MOUSE	BCL-6 corepressor (BCoR)	Mus musculus (Mouse)	blastocyst hatching [GO:0001835]; chromatin remodeling [GO:0006338]; heart development [GO:0007507]; negative regulation of bone mineralization [GO:0030502]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of tooth mineralization [GO:0070171]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; roof of mouth development [GO:0060021]; specification of axis polarity [GO:0065001]	DNA-binding transcription factor binding [GO:0140297]; heat shock protein binding [GO:0031072]; histone deacetylase binding [GO:0042826]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription cis-regulatory region binding [GO:0000976]; transcription corepressor activity [GO:0003714]; ubiquitin-protein transferase activity [GO:0004842]	BCOR complex [GO:0140261]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000122; GO:0000976; GO:0000977; GO:0001835; GO:0003714; GO:0004842; GO:0005634; GO:0005654; GO:0006338; GO:0007507; GO:0030502; GO:0031072; GO:0042476; GO:0042826; GO:0045892; GO:0060021; GO:0065001; GO:0070171; GO:0140261; GO:0140297
GN021238	GN021238.1	B3EWZ3	44.0	134	710	1675	9.01e-26	117	CADN_ACRMI	Coadhesin	Acropora millepora (Staghorn coral) (Heteropora millepora)			membrane [GO:0016020]	GO:0016020
GN021239	GN021239.1	P35441	34.3	230	891	1170	6.90e-36	150	TSP1_MOUSE	Thrombospondin-1 (Glycoprotein G)	Mus musculus (Mouse)	behavioral response to pain [GO:0048266]; blood coagulation, fibrin clot formation [GO:0072378]; blood vessel morphogenesis [GO:0048514]; cell migration [GO:0016477]; cellular response to nitric oxide [GO:0071732]; endocardial cushion development [GO:0003197]; endothelial cell-cell adhesion [GO:0071603]; engulfment of apoptotic cell [GO:0043652]; growth plate cartilage development [GO:0003417]; inflammatory response [GO:0006954]; monocyte aggregation [GO:0070487]; negative regulation of angiogenesis [GO:0016525]; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002581]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of long-chain fatty acid import across plasma membrane [GO:0010748]; negative regulation of nitric oxide-cGMP mediated signal transduction [GO:0141151]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of receptor guanylyl cyclase signaling pathway [GO:0010754]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide-cGMP-mediated signaling [GO:0038060]; outflow tract morphogenesis [GO:0003151]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phosphorylation [GO:0042327]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transforming growth factor beta production [GO:0071636]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor production [GO:0032760]; response to calcium ion [GO:0051592]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to magnesium ion [GO:0032026]; response to mechanical stimulus [GO:0009612]; sprouting angiogenesis [GO:0002040]	calcium ion binding [GO:0005509]; collagen V binding [GO:0070052]; endopeptidase inhibitor activity [GO:0004866]; extracellular matrix binding [GO:0050840]; fibrinogen binding [GO:0070051]; fibroblast growth factor binding [GO:0017134]; fibronectin binding [GO:0001968]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; laminin binding [GO:0043236]; low-density lipoprotein particle binding [GO:0030169]; phosphatidylserine binding [GO:0001786]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; transforming growth factor beta binding [GO:0050431]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; fibrinogen complex [GO:0005577]; platelet alpha granule [GO:0031091]; sarcoplasmic reticulum [GO:0016529]; secretory granule [GO:0030141]; thrombospondin complex [GO:1990341]	GO:0001786; GO:0001937; GO:0001953; GO:0001968; GO:0002020; GO:0002040; GO:0002581; GO:0002605; GO:0003151; GO:0003197; GO:0003417; GO:0004866; GO:0005178; GO:0005509; GO:0005576; GO:0005577; GO:0005783; GO:0006954; GO:0008201; GO:0008284; GO:0008285; GO:0009612; GO:0009749; GO:0009897; GO:0009986; GO:0010595; GO:0010596; GO:0010748; GO:0010754; GO:0010757; GO:0010759; GO:0010763; GO:0010811; GO:0016477; GO:0016525; GO:0016529; GO:0017134; GO:0030141; GO:0030169; GO:0030335; GO:0030511; GO:0031012; GO:0031091; GO:0032026; GO:0032693; GO:0032695; GO:0032720; GO:0032760; GO:0034976; GO:0038060; GO:0040037; GO:0042327; GO:0042803; GO:0043032; GO:0043066; GO:0043236; GO:0043410; GO:0043536; GO:0043537; GO:0043652; GO:0045727; GO:0045766; GO:0048266; GO:0048514; GO:0048661; GO:0050431; GO:0050840; GO:0050921; GO:0051592; GO:0051897; GO:0051918; GO:0070051; GO:0070052; GO:0070487; GO:0071603; GO:0071636; GO:0071732; GO:0072378; GO:0090051; GO:0141151; GO:1902043; GO:1903588; GO:1903671; GO:1990341; GO:2000353; GO:2000379; GO:2001027
GN021240	GN021240.1	D3YXG0	23.8	421	880	5634	1.81e-11	72.4	HMCN1_MOUSE	Hemicentin-1 (Fibulin-6) (FIBL-6)	Mus musculus (Mouse)	actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; heterophilic cell-cell adhesion [GO:0007157]; homophilic cell-cell adhesion [GO:0007156]; response to bacterium [GO:0009617]	calcium ion binding [GO:0005509]; cell adhesion mediator activity [GO:0098631]	adherens junction [GO:0005912]; anchoring junction [GO:0070161]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; muscle tendon junction [GO:0005927]; non-collagenous component of basement membrane [GO:0140144]; plasma membrane [GO:0005886]	GO:0005509; GO:0005576; GO:0005604; GO:0005737; GO:0005886; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0009617; GO:0030036; GO:0030054; GO:0031012; GO:0032154; GO:0070161; GO:0071711; GO:0098631; GO:0140144
GN021242	GN021242.1	B3EWZ3	43.4	122	305	1675	2.23e-20	95.1	CADN_ACRMI	Coadhesin	Acropora millepora (Staghorn coral) (Heteropora millepora)			membrane [GO:0016020]	GO:0016020
GN021243	GN021243.1	Q9SE95	53.7	95	544	298	6.89e-21	96.7	FIP2_ARATH	FH protein interacting protein FIP2 (BTB/POZ domain-containing protein At5g55000)	Arabidopsis thaliana (Mouse-ear cress)	protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]		extracellular region [GO:0005576]	GO:0005576; GO:0016567; GO:0051260
GN021244	GN021244.1	B0BM20	35.9	590	595	574	4.10e-84	276	ENO4_XENTR	Enolase 4 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	glycolytic process [GO:0006096]	magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]	phosphopyruvate hydratase complex [GO:0000015]	GO:0000015; GO:0000287; GO:0004634; GO:0006096
GN021245	GN021245.1	Q6DF30	42.2	327	331	330	3.56e-93	283	DHDH_XENTR	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-arabinose 1-dehydrogenase) (EC 1.1.1.-) (D-galactose 1-dehydrogenase) (EC 1.1.1.120) (D-glucose 1-dehydrogenase) (EC 1.1.1.119) (D-ribose 1-dehydrogenase) (EC 1.1.1.115) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	D-xylose catabolic process [GO:0042843]	D-xylose 1-dehydrogenase (NADP+) activity [GO:0047837]; galactose 1-dehydrogenase (NADP+) activity [GO:0047910]; glucose 1-dehydrogenase (NADP+) activity [GO:0047935]; nucleotide binding [GO:0000166]; ribose 1-dehydrogenase (NADP+) activity [GO:0050259]; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115]		GO:0000166; GO:0042843; GO:0047115; GO:0047837; GO:0047910; GO:0047935; GO:0050259
GN021246	GN021246.1	Q6PFX9	76.6	1151	1157	1320	0.0	1043	TNKS1_MOUSE	Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TRF1-interacting ankyrin-related ADP-ribose polymerase 1) (Tankyrase I) (Tankyrase-1) (TANK1)	Mus musculus (Mouse)	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; regulation of telomere maintenance via telomerase [GO:0032210]	histone binding [GO:0042393]; NAD+ poly-ADP-ribosyltransferase activity [GO:0003950]; NAD+-protein mono-ADP-ribosyltransferase activity [GO:1990404]; NAD+-protein-aspartate ADP-ribosyltransferase activity [GO:0140806]; NAD+-protein-glutamate ADP-ribosyltransferase activity [GO:0140807]; telomerase inhibitor activity [GO:0010521]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000139; GO:0000209; GO:0000781; GO:0003950; GO:0005634; GO:0005643; GO:0005654; GO:0005737; GO:0005794; GO:0005813; GO:0005829; GO:0008270; GO:0010521; GO:0016604; GO:0018105; GO:0018107; GO:0031965; GO:0032210; GO:0032212; GO:0042393; GO:0045944; GO:0070198; GO:0070212; GO:0070213; GO:0090263; GO:0097431; GO:0140806; GO:0140807; GO:1904355; GO:1904357; GO:1904358; GO:1904908; GO:1990404
GN021247	GN021247.1	Q8BN82	43.3	485	548	495	1.34e-126	382	S17A5_MOUSE	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)	Mus musculus (Mouse)	neurotransmitter loading into synaptic vesicle [GO:0098700]; response to bacterium [GO:0009617]; sialic acid transport [GO:0015739]	D-glucuronate transmembrane transporter activity [GO:0042880]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	GO:0005764; GO:0005765; GO:0005829; GO:0005886; GO:0009617; GO:0015136; GO:0015538; GO:0015739; GO:0016323; GO:0016324; GO:0030672; GO:0031410; GO:0042880; GO:0098700; GO:0098978
GN021248	GN021248.1	Q8BN82	45.7	317	335	495	7.12e-92	285	S17A5_MOUSE	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)	Mus musculus (Mouse)	neurotransmitter loading into synaptic vesicle [GO:0098700]; response to bacterium [GO:0009617]; sialic acid transport [GO:0015739]	D-glucuronate transmembrane transporter activity [GO:0042880]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]	GO:0005764; GO:0005765; GO:0005829; GO:0005886; GO:0009617; GO:0015136; GO:0015538; GO:0015739; GO:0016323; GO:0016324; GO:0030672; GO:0031410; GO:0042880; GO:0098700; GO:0098978
GN021250	GN021250.1	Q5XI70	36.7	248	328	351	1.30e-35	135	PCGF6_RAT	Polycomb group RING finger protein 6 (RING finger protein 134)	Rattus norvegicus (Rat)	chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]		nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]	GO:0000122; GO:0005634; GO:0006338; GO:0006357; GO:0031519; GO:0035102; GO:0045892
GN021252	GN021252.1	O00567	69.7	435	528	594	8.65e-213	605	NOP56_HUMAN	Nucleolar protein 56 (Nucleolar protein 5A)	Homo sapiens (Human)	maturation of SSU-rRNA [GO:0030490]; mRNA modification [GO:0016556]; neuron differentiation [GO:0030182]; ribosomal small subunit biogenesis [GO:0042274]; rRNA 2'-O-methylation [GO:0000451]; rRNA processing [GO:0006364]	cadherin binding [GO:0045296]; histone methyltransferase binding [GO:1990226]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]	box C/D methylation guide snoRNP complex [GO:0031428]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pre-snoRNP complex [GO:0070761]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]	GO:0000451; GO:0001650; GO:0003723; GO:0005654; GO:0005730; GO:0005732; GO:0005737; GO:0006364; GO:0016020; GO:0016556; GO:0030182; GO:0030490; GO:0030515; GO:0031428; GO:0032040; GO:0042274; GO:0045296; GO:0070761; GO:1990226
GN021255	GN021255.1	Q7PCJ9	51.8	168	168	170	3.20e-57	179	SAT2_PIG	Thialysine N-epsilon-acetyltransferase (EC 2.3.1.-) (Diamine acetyltransferase 2) (EC 2.3.1.57) (Spermidine/spermine N(1)-acetyltransferase 2) (SSAT-2)	Sus scrofa (Pig)	polyamine metabolic process [GO:0006595]	diamine N-acetyltransferase activity [GO:0004145]; N-acetyltransferase activity [GO:0008080]	cytoplasm [GO:0005737]	GO:0004145; GO:0005737; GO:0006595; GO:0008080
GN021256	GN021256.1	P11438	27.6	416	711	406	1.54e-25	113	LAMP1_MOUSE	Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (120 kDa lysosomal membrane glycoprotein) (CD107 antigen-like family member A) (LGP-120) (Lysosomal membrane glycoprotein A) (LGP-A) (P2B) (CD antigen CD107a)	Mus musculus (Mouse)	autophagic cell death [GO:0048102]; establishment of protein localization to organelle [GO:0072594]; Golgi to lysosome transport [GO:0090160]; granzyme-mediated programmed cell death signaling pathway [GO:0140507]; lysosomal lumen acidification [GO:0007042]; lysosomal lumen pH elevation [GO:0035752]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; protein stabilization [GO:0050821]; proton transmembrane transport [GO:1902600]; regulation of organelle transport along microtubule [GO:1902513]; spermatogenesis [GO:0007283]	enzyme binding [GO:0019899]; ion channel inhibitor activity [GO:0008200]; protein domain specific binding [GO:0019904]	alveolar lamellar body [GO:0097208]; autolysosome [GO:0044754]; autophagosome membrane [GO:0000421]; cell surface [GO:0009986]; cytolytic granule [GO:0044194]; cytolytic granule membrane [GO:0101004]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endosome [GO:0005768]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome [GO:0042470]; multivesicular body [GO:0005771]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; phagolysosome membrane [GO:0061474]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; sarcolemma [GO:0042383]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982]	GO:0000421; GO:0005737; GO:0005764; GO:0005765; GO:0005768; GO:0005770; GO:0005771; GO:0005829; GO:0005886; GO:0007042; GO:0007283; GO:0008021; GO:0008200; GO:0009897; GO:0009986; GO:0010008; GO:0019899; GO:0019904; GO:0030425; GO:0030672; GO:0031902; GO:0031982; GO:0035752; GO:0042383; GO:0042470; GO:0043025; GO:0043323; GO:0044194; GO:0044754; GO:0045335; GO:0045954; GO:0048102; GO:0048471; GO:0050821; GO:0061474; GO:0072594; GO:0090160; GO:0097208; GO:0098794; GO:0098978; GO:0101004; GO:0140507; GO:1902513; GO:1902600
GN021258	GN021258.1	Q8VEL0	53.3	214	211	213	1.96e-69	214	MSPD1_MOUSE	Motile sperm domain-containing protein 1	Mus musculus (Mouse)	negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]		cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0000122; GO:0000139; GO:0005634; GO:0005737; GO:0005789; GO:0045944; GO:0048471
GN021259	GN021259.1	Q5DU57	46.7	557	4640	656	2.72e-148	482	SPT13_MOUSE	Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2)	Mus musculus (Mouse)	cell migration [GO:0016477]; filopodium assembly [GO:0046847]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; regulation of cell migration [GO:0030334]	guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; podosome [GO:0002102]; ruffle membrane [GO:0032587]	GO:0002102; GO:0005085; GO:0005654; GO:0005737; GO:0005829; GO:0016477; GO:0030027; GO:0030032; GO:0030175; GO:0030334; GO:0032587; GO:0035556; GO:0042802; GO:0046847
GN021260	GN021260.1	O68965	38.0	276	325	330	1.22e-60	199	MI2D_RHIME	Inositol 2-dehydrogenase (EC 1.1.1.18) (Myo-inositol 2-dehydrogenase) (MI-dehydrogenase)	Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)	NADPH regeneration [GO:0006740]	inositol 2-dehydrogenase (NAD+) activity [GO:0050112]; nucleotide binding [GO:0000166]	cytoplasm [GO:0005737]	GO:0000166; GO:0005737; GO:0006740; GO:0050112
GN021262	GN021262.1	Q9NQY0	40.7	199	216	253	4.41e-44	150	BIN3_HUMAN	Bridging integrator 3	Homo sapiens (Human)	actin cortical patch localization [GO:0051666]; actin filament organization [GO:0007015]; cytoskeleton-dependent cytokinesis [GO:0061640]; endocytosis [GO:0006897]; intracellular protein localization [GO:0008104]; plasma membrane tubulation [GO:0097320]; unidimensional cell growth [GO:0009826]	cytoskeletal adaptor activity [GO:0008093]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]	GO:0005737; GO:0006897; GO:0007015; GO:0008093; GO:0008104; GO:0009826; GO:0015629; GO:0051666; GO:0061640; GO:0097320
GN021263	GN021263.1	P29183	44.4	214	235	461	1.79e-45	160	LIPP_HORSE	Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3)	Equus caballus (Horse)	cholesterol homeostasis [GO:0042632]; fatty acid biosynthetic process [GO:0006633]; high-density lipoprotein particle remodeling [GO:0034375]; triglyceride catabolic process [GO:0019433]	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity [GO:0047376]; glycerophospholipid phospholipase A1 activity [GO:0008970]; lipoprotein lipase activity [GO:0004465]; triacylglycerol lipase activity [GO:0004806]	extracellular region [GO:0005576]	GO:0004465; GO:0004806; GO:0005576; GO:0006633; GO:0008970; GO:0019433; GO:0034375; GO:0042632; GO:0047376
GN021266	GN021266.1	Q7T0X5	24.0	233	323	422	6.60e-13	72.4	CHMP7_XENLA	Charged multivesicular body protein 7 (Chromatin-modifying protein 7)	Xenopus laevis (African clawed frog)	exit from mitosis [GO:0010458]; late endosome to vacuole transport [GO:0045324]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; nuclear membrane reassembly [GO:0031468]; vesicle budding from membrane [GO:0006900]		cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; ESCRT III complex [GO:0000815]; multivesicular body [GO:0005771]; nuclear envelope [GO:0005635]	GO:0000815; GO:0005635; GO:0005737; GO:0005771; GO:0006900; GO:0009898; GO:0010458; GO:0031468; GO:0032511; GO:0045324
GN021267	GN021267.1	Q0P4S0	34.7	842	708	951	2.17e-104	343	LST2_XENTR	Lateral signaling target protein 2 homolog (Zinc finger FYVE domain-containing protein 28)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]	metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]	GO:0005829; GO:0007175; GO:0031901; GO:0032266; GO:0042059; GO:0046872
GN021268	GN021268.1	Q8AW42	54.6	304	384	348	2.40e-93	286	S39AD_DANRE	Zinc transporter ZIP13 (Solute carrier family 39 member 13) (Zrt- and Irt-like protein 13) (ZIP-13)	Danio rerio (Zebrafish) (Brachydanio rerio)	intracellular zinc ion homeostasis [GO:0006882]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]	zinc ion transmembrane transporter activity [GO:0005385]	cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]	GO:0000139; GO:0005385; GO:0005789; GO:0006829; GO:0006882; GO:0030659; GO:0071577
GN021270	GN021270.1	Q8BKC5	56.8	1092	1095	1097	0.0	1274	IPO5_MOUSE	Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)	Mus musculus (Mouse)	cellular response to amino acid stimulus [GO:0071230]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus [GO:0006606]; ribosomal protein import into nucleus [GO:0006610]	nuclear import signal receptor activity [GO:0061608]; nuclear localization sequence binding [GO:0008139]; small GTPase binding [GO:0031267]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0002753; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006606; GO:0006607; GO:0006610; GO:0008139; GO:0031267; GO:0031965; GO:0042307; GO:0061608; GO:0071230
GN021274	GN021274.1	Q9Z1Z1	36.2	1039	1005	1108	7.00e-168	524	E2AK3_RAT	Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2)	Rattus norvegicus (Rat)	angiogenesis [GO:0001525]; bone mineralization [GO:0030282]; calcium-mediated signaling [GO:0019722]; cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to glucose starvation [GO:0042149]; chondrocyte development [GO:0002063]; eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492]; endocrine pancreas development [GO:0031018]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; ERAD pathway [GO:0036503]; fat cell differentiation [GO:0045444]; insulin-like growth factor receptor signaling pathway [GO:0048009]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; lactation [GO:0007595]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of myelination [GO:0031642]; negative regulation of translation [GO:0017148]; negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010]; negative regulation of translation in response to stress [GO:0032055]; ossification [GO:0001503]; pancreas development [GO:0031016]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of gene expression [GO:0010628]; positive regulation of glutathione biosynthetic process [GO:1903788]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of signal transduction [GO:0009967]; positive regulation of transcription by RNA polymerase I [GO:0045943]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:0060734]; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902235]; regulation of fatty acid metabolic process [GO:0019217]; regulation of translation initiation in response to endoplasmic reticulum stress [GO:0036491]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; regulation of translational initiation in response to stress [GO:0043558]; response to endoplasmic reticulum stress [GO:0034976]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; skeletal system development [GO:0001501]; SREBP signaling pathway [GO:0032933]; translation [GO:0006412]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; misfolded protein binding [GO:0051787]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; translation regulator activity [GO:0045182]	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; mitochondria-associated endoplasmic reticulum membrane contact site [GO:0044233]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0001501; GO:0001503; GO:0001525; GO:0002063; GO:0004672; GO:0004674; GO:0004694; GO:0004713; GO:0004715; GO:0005524; GO:0005634; GO:0005737; GO:0005783; GO:0005789; GO:0006412; GO:0006446; GO:0006468; GO:0006983; GO:0007029; GO:0007595; GO:0009967; GO:0010575; GO:0010628; GO:0010629; GO:0010998; GO:0017148; GO:0019217; GO:0019722; GO:0019899; GO:0019903; GO:0030282; GO:0030968; GO:0031016; GO:0031018; GO:0031642; GO:0032055; GO:0032933; GO:0034198; GO:0034976; GO:0036491; GO:0036492; GO:0036499; GO:0036503; GO:0042149; GO:0042802; GO:0043066; GO:0043558; GO:0044233; GO:0044322; GO:0045182; GO:0045444; GO:0045943; GO:0045944; GO:0046777; GO:0048009; GO:0048471; GO:0051787; GO:0051879; GO:0060734; GO:0070059; GO:0070417; GO:0106310; GO:1900182; GO:1902010; GO:1902235; GO:1902237; GO:1903788; GO:1990737
GN021277	GN021277.1	O95210	35.7	98	111	358	4.61e-11	61.2	STBD1_HUMAN	Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1)	Homo sapiens (Human)	glycogen catabolic process [GO:0005980]; glycophagy [GO:0061723]; lysosomal transport [GO:0007041]; substrate localization to autophagosome [GO:0061753]	cargo receptor activity [GO:0038024]; enzyme binding [GO:0019899]; glycogen binding [GO:2001069]; polysaccharide binding [GO:0030247]; starch binding [GO:2001070]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ficolin-1-rich granule membrane [GO:0101003]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site membrane [GO:0034045]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; tertiary granule membrane [GO:0070821]	GO:0005783; GO:0005789; GO:0005886; GO:0005980; GO:0007041; GO:0016020; GO:0019899; GO:0030247; GO:0030315; GO:0034045; GO:0038024; GO:0048471; GO:0061723; GO:0061753; GO:0070821; GO:0101003; GO:2001069; GO:2001070
GN021279	GN021279.1	Q91VL8	33.5	173	754	393	1.27e-13	77.0	TE2IP_MOUSE	Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Repressor/activator protein 1 homolog) (RAP1 homolog)	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; negative regulation of DNA recombination at telomere [GO:0048239]; negative regulation of telomere maintenance [GO:0032205]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of telomere maintenance [GO:0032206]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of DNA-templated transcription [GO:0006355]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of telomere maintenance [GO:0032204]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]	G-rich strand telomeric DNA binding [GO:0098505]; phosphatase binding [GO:0019902]; telomeric repeat DNA binding [GO:0042162]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; shelterin complex [GO:0070187]	GO:0000723; GO:0000781; GO:0000783; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006355; GO:0010569; GO:0010833; GO:0016233; GO:0016604; GO:0019902; GO:0031848; GO:0032204; GO:0032205; GO:0032206; GO:0035556; GO:0042162; GO:0043123; GO:0048239; GO:0070187; GO:0070198; GO:0098505; GO:1901224
GN021280	GN021280.1	P31320	25.5	235	505	403	1.20e-13	76.3	KAPR_BLAEM	cAMP-dependent protein kinase regulatory subunit (PKA regulatory subunit)	Blastocladiella emersonii (Aquatic fungus)	cellular response to stress [GO:0033554]	cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; protein kinase A catalytic subunit binding [GO:0034236]	cAMP-dependent protein kinase complex [GO:0005952]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004862; GO:0005634; GO:0005829; GO:0005952; GO:0030552; GO:0033554; GO:0034236
GN021282	GN021282.1	P35270	38.4	263	271	261	5.33e-54	178	SPRE_HUMAN	Sepiapterin reductase (SPR) (EC 1.1.1.153)	Homo sapiens (Human)	nitric oxide biosynthetic process [GO:0006809]; tetrahydrobiopterin biosynthetic process [GO:0006729]	alcohol dehydrogenase (NADP+) activity [GO:0008106]; NADP binding [GO:0050661]; sepiapterin reductase (NADP+) activity [GO:0004757]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	GO:0004757; GO:0005739; GO:0005829; GO:0006729; GO:0006809; GO:0008106; GO:0050661; GO:0070062
GN021283	GN021283.1	Q9Y2D4	57.3	815	835	811	1.27e-318	895	EXC6B_HUMAN	Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2)	Homo sapiens (Human)	exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]		exocyst [GO:0000145]; plasma membrane [GO:0005886]	GO:0000145; GO:0000281; GO:0005886; GO:0006886; GO:0006887; GO:0006893; GO:0006904; GO:0090148; GO:0090522
GN021285	GN021285.1	Q8Y3S3	36.7	169	1091	176	3.23e-19	89.7	Y2759_LISMO	Macro domain-containing protein lmo2759	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)				
GN021286	GN021286.1	Q6NS46	56.7	104	111	1862	3.35e-34	127	RRP5_MOUSE	Protein RRP5 homolog (Apoptosis-linked gene 4 protein) (Programmed cell death protein 11)	Mus musculus (Mouse)	rRNA processing [GO:0006364]	NF-kappaB binding [GO:0051059]; RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; small-subunit processome [GO:0032040]	GO:0003723; GO:0005634; GO:0005730; GO:0005829; GO:0006364; GO:0032040; GO:0051059
GN021289	GN021289.1	F1RD85	49.2	315	956	739	1.36e-89	305	LOX3A_DANRE	Lysyl oxidase homolog 3A (EC 1.4.3.-) (EC 1.4.3.13) (Lysyl oxidase-like protein 3A)	Danio rerio (Zebrafish) (Brachydanio rerio)	collagen fibril organization [GO:0030199]; fibronectin fibril organization [GO:1905590]; inflammatory response [GO:0006954]; lung development [GO:0030324]; negative regulation of T-helper 17 cell lineage commitment [GO:2000329]; peptidyl-lysine oxidation [GO:0018057]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; roof of mouth development [GO:0060021]; somite development [GO:0061053]; spinal cord development [GO:0021510]	copper ion binding [GO:0005507]; fibronectin binding [GO:0001968]; protein-lysine 6-oxidase activity [GO:0004720]	cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0001968; GO:0004720; GO:0005507; GO:0005576; GO:0005634; GO:0005737; GO:0006954; GO:0016020; GO:0018057; GO:0021510; GO:0030199; GO:0030324; GO:0031012; GO:0060021; GO:0061053; GO:1905590; GO:2000329; GO:2001046
GN021292	GN021292.1	Q5BIM1	22.2	460	747	580	1.19e-18	94.0	TRI45_BOVIN	E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99) (Tripartite motif-containing protein 45)	Bos taurus (Bovine)		ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0061630
GN021295	GN021295.1	Q6INN8	35.3	312	314	632	6.69e-48	172	SAMH1_XENLA	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-)	Xenopus laevis (African clawed frog)	dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; deoxyribonucleotide catabolic process [GO:0009264]; dGTP catabolic process [GO:0006203]; DNA damage response [GO:0006974]; DNA strand resection involved in replication fork processing [GO:0110025]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; protein homotetramerization [GO:0051289]; regulation of innate immune response [GO:0045088]; somatic hypermutation of immunoglobulin genes [GO:0016446]	deoxynucleoside triphosphate hydrolase activity [GO:0106375]; dGTP binding [GO:0032567]; dGTPase activity [GO:0008832]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; triphosphoric monoester hydrolase activity [GO:0016793]; zinc ion binding [GO:0008270]	chromosome [GO:0005694]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]	GO:0000724; GO:0003676; GO:0003697; GO:0003723; GO:0005634; GO:0005694; GO:0006203; GO:0006974; GO:0008270; GO:0008832; GO:0009264; GO:0016446; GO:0016793; GO:0032567; GO:0035861; GO:0045088; GO:0046061; GO:0051289; GO:0051607; GO:0060339; GO:0106375; GO:0110025
GN021296	GN021296.1	O93530	39.9	148	143	1436	2.67e-23	97.8	WRN_XENLA	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Focus-forming activity 1) (FFA-1) (Werner syndrome protein homolog) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]	Xenopus laevis (African clawed frog)	DNA geometric change [GO:0032392]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; telomere maintenance [GO:0000723]	3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; four-way junction helicase activity [GO:0009378]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleic acid binding [GO:0003676]	chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000287; GO:0000723; GO:0000724; GO:0000781; GO:0003676; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006259; GO:0006260; GO:0008408; GO:0009378; GO:0016887; GO:0030145; GO:0032392; GO:0043138
GN021299	GN021299.1	A2TIL1	63.6	459	452	522	6.86e-204	577	GSHR_CALJA	Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7)	Callithrix jacchus (White-tufted-ear marmoset) (Simia Jacchus)	cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glutathione metabolic process [GO:0006749]	flavin adenine dinucleotide binding [GO:0050660]; glutathione-disulfide reductase (NADPH) activity [GO:0004362]; NADP binding [GO:0050661]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0004362; GO:0005737; GO:0005739; GO:0005829; GO:0006749; GO:0034599; GO:0045454; GO:0050660; GO:0050661
GN021300	GN021300.1	Q8BXH3	33.9	708	734	824	2.84e-124	393	GCYB2_MOUSE	Guanylate cyclase soluble subunit beta-2 (GCS-beta-2) (EC 4.6.1.2) (guanylate cyclase) (EC 4.6.1.2)	Mus musculus (Mouse)	intracellular signal transduction [GO:0035556]; response to oxygen levels [GO:0070482]	guanylate cyclase activity [GO:0004383]; heme binding [GO:0020037]; nitric oxide binding [GO:0070026]	cytosol [GO:0005829]; dendritic knob [GO:0098788]; guanylate cyclase complex, soluble [GO:0008074]	GO:0004383; GO:0005829; GO:0008074; GO:0020037; GO:0035556; GO:0070026; GO:0070482; GO:0098788
GN021302	GN021302.1	P48818	63.1	586	847	655	3.41e-252	720	ACADV_BOVIN	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) (Long-chain specific acyl-CoA dehydrogenase, mitochondrial) (EC 1.3.8.8)	Bos taurus (Bovine)	fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]	acyl-CoA dehydrogenase activity [GO:0003995]; fatty-acyl-CoA binding [GO:0000062]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; long-chain fatty acyl-CoA dehydrogenase activity [GO:0004466]; medium-chain fatty acyl-CoA dehydrogenase activity [GO:0070991]; very-long-chain fatty acyl-CoA dehydrogenase activity [GO:0017099]	mitochondrial inner membrane [GO:0005743]	GO:0000062; GO:0003995; GO:0004466; GO:0005743; GO:0017099; GO:0033539; GO:0042802; GO:0050660; GO:0070991
GN021306	GN021306.1	P51841	53.3	599	967	1108	1.67e-198	603	GUC2F_HUMAN	Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2)	Homo sapiens (Human)	cGMP biosynthetic process [GO:0006182]; detection of light stimulus involved in visual perception [GO:0050908]; intracellular signal transduction [GO:0035556]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of opsin-mediated signaling pathway [GO:0022400]; visual perception [GO:0007601]	ATP binding [GO:0005524]; guanylate cyclase activity [GO:0004383]; identical protein binding [GO:0042802]; peptide receptor activity [GO:0001653]; protein heterodimerization activity [GO:0046982]; protein kinase activity [GO:0004672]; signaling receptor activity [GO:0038023]	nuclear outer membrane [GO:0005640]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; rod photoreceptor disc membrane [GO:0120202]; rod photoreceptor outer segment [GO:0120200]	GO:0001653; GO:0004383; GO:0004672; GO:0005524; GO:0005640; GO:0005886; GO:0006182; GO:0007168; GO:0007601; GO:0022400; GO:0035556; GO:0038023; GO:0042622; GO:0042802; GO:0046982; GO:0050908; GO:0097381; GO:0120200; GO:0120202
GN021307	GN021307.1	Q9BSG0	45.9	159	268	188	2.55e-44	151	PADC1_HUMAN	Protease-associated domain-containing protein 1 (Protease-associated domain-containing protein of 21 kDa) (hPAP21)	Homo sapiens (Human)			extracellular region [GO:0005576]	GO:0005576
GN021308	GN021308.1	Q9P0J7	50.8	354	493	381	1.49e-91	286	KCMF1_HUMAN	E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1)	Homo sapiens (Human)	HRI-mediated signaling [GO:0140468]; negative regulation of HRI-mediated signaling [GO:0141191]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; response to oxidative stress [GO:0006979]; synaptic signaling [GO:0099536]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; synapse [GO:0045202]; ubiquitin ligase complex [GO:0000151]	GO:0000151; GO:0005576; GO:0005737; GO:0005764; GO:0005770; GO:0005829; GO:0005886; GO:0006511; GO:0006979; GO:0008270; GO:0043161; GO:0045202; GO:0061630; GO:0070534; GO:0070936; GO:0099536; GO:0140468; GO:0141191; GO:1904813
GN021309	GN021309.1	Q2HJG2	56.7	541	585	530	6.04e-174	506	PUF60_BOVIN	Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor)	Bos taurus (Bovine)	alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splice site recognition [GO:0006376]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]	RNA binding [GO:0003723]	nucleus [GO:0005634]	GO:0000380; GO:0000381; GO:0003723; GO:0005634; GO:0006376
GN021310	GN021310.1	Q8K385	40.5	158	233	592	2.68e-22	98.2	FRRS1_MOUSE	Ferric reductase 1 (EC 1.-.-.-) (Ferric-chelate reductase 1) (Stromal cell-derived receptor 2) (SDR-2)	Mus musculus (Mouse)	intracellular iron ion homeostasis [GO:0006879]	oxidoreductase activity, acting on metal ions [GO:0016722]	membrane [GO:0016020]	GO:0006879; GO:0016020; GO:0016722
GN021313	GN021313.1	Q3V096	60.2	452	516	527	3.12e-68	231	ANR42_MOUSE	Ankyrin repeat domain-containing protein 42	Mus musculus (Mouse)	positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]	cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861]; NF-kappaB binding [GO:0051059]	nucleus [GO:0005634]	GO:0004861; GO:0005634; GO:0043123; GO:0051059; GO:1900017
GN021314	GN021314.1	Q5R9R1	38.5	1172	1131	1204	1.57e-202	622	EDRF1_PONAB	Erythroid differentiation-related factor 1	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)	positive regulation of DNA-templated transcription [GO:0045893]		nucleus [GO:0005634]	GO:0005634; GO:0045893
GN021315	GN021315.1	Q69ZK9	35.1	724	879	836	4.33e-118	382	NLGN2_MOUSE	Neuroligin-2	Mus musculus (Mouse)	gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; inhibitory synapse assembly [GO:1904862]; insulin metabolic process [GO:1901142]; jump response [GO:0007630]; locomotory exploration behavior [GO:0035641]; modulation of chemical synaptic transmission [GO:0050804]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter-gated ion channel clustering [GO:0072578]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle clustering [GO:2000809]; positive regulation of t-SNARE clustering [GO:1904034]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; postsynaptic specialization assembly [GO:0098698]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein localization to cell surface [GO:0034394]; protein localization to synapse [GO:0035418]; regulation of presynapse assembly [GO:1905606]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; sensory perception of pain [GO:0019233]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic transmission, GABAergic [GO:0051932]; terminal button organization [GO:0072553]; thigmotaxis [GO:0001966]	cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; identical protein binding [GO:0042802]; neurexin family protein binding [GO:0042043]	axon [GO:0030424]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; dopaminergic synapse [GO:0098691]; excitatory synapse [GO:0060076]; GABA-ergic synapse [GO:0098982]; glycinergic synapse [GO:0098690]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; presynaptic membrane [GO:0042734]; ribbon synapse [GO:0097470]; synapse [GO:0045202]	GO:0001966; GO:0002087; GO:0005886; GO:0007158; GO:0007416; GO:0007630; GO:0008284; GO:0009986; GO:0019233; GO:0030424; GO:0030425; GO:0032024; GO:0032230; GO:0034394; GO:0035176; GO:0035418; GO:0035641; GO:0042043; GO:0042734; GO:0042802; GO:0043197; GO:0043198; GO:0045202; GO:0045211; GO:0050804; GO:0050808; GO:0050839; GO:0050885; GO:0051932; GO:0051965; GO:0051968; GO:0060076; GO:0060077; GO:0060999; GO:0072553; GO:0072578; GO:0097104; GO:0097105; GO:0097116; GO:0097119; GO:0097151; GO:0097470; GO:0098631; GO:0098690; GO:0098691; GO:0098698; GO:0098982; GO:0099054; GO:0099634; GO:1901142; GO:1902474; GO:1904034; GO:1904862; GO:1905606; GO:2000463; GO:2000809
GN021316	GN021316.1	Q8N0W4	33.2	710	860	816	1.44e-104	345	NLGNX_HUMAN	Neuroligin-4, X-linked (Neuroligin X) (HNLX)	Homo sapiens (Human)	adult behavior [GO:0030534]; brainstem development [GO:0003360]; cell-cell junction organization [GO:0045216]; cerebellum development [GO:0021549]; learning [GO:0007612]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of excitatory postsynaptic potential [GO:0090394]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; organ growth [GO:0035265]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; regulation of synapse assembly [GO:0051963]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; vocalization behavior [GO:0071625]	cell adhesion mediator activity [GO:0098631]; cell adhesion molecule binding [GO:0050839]; chloride ion binding [GO:0031404]; neurexin family protein binding [GO:0042043]; protein homodimerization activity [GO:0042803]; scaffold protein binding [GO:0097110]	asymmetric, glutamatergic, excitatory synapse [GO:0098985]; cell surface [GO:0009986]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; excitatory synapse [GO:0060076]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic specialization membrane [GO:0099634]; symmetric, GABA-ergic, inhibitory synapse [GO:0098983]; synapse [GO:0045202]	GO:0003360; GO:0005886; GO:0007158; GO:0007416; GO:0007612; GO:0009986; GO:0016020; GO:0021549; GO:0030182; GO:0030425; GO:0030534; GO:0031404; GO:0035176; GO:0035265; GO:0042043; GO:0042803; GO:0043197; GO:0045202; GO:0045216; GO:0050804; GO:0050808; GO:0050839; GO:0051963; GO:0060076; GO:0071625; GO:0090394; GO:0097105; GO:0097110; GO:0098631; GO:0098839; GO:0098978; GO:0098982; GO:0098983; GO:0098985; GO:0099054; GO:0099634
GN021319	GN021319.1	P00178	36.7	471	498	491	2.72e-84	271	CP2B4_RABIT	Cytochrome P450 2B4 (EC 1.14.14.1) (CYPIIB4) (Cytochrome P450 isozyme 2) (Cytochrome P450 LM2) (Cytochrome P450 type B0) (Cytochrome P450 type B1)	Oryctolagus cuniculus (Rabbit)	epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805]	arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005789; GO:0006805; GO:0008392; GO:0016712; GO:0019373; GO:0020037
GN021320	GN021320.1	P00178	36.7	471	498	491	1.15e-86	278	CP2B4_RABIT	Cytochrome P450 2B4 (EC 1.14.14.1) (CYPIIB4) (Cytochrome P450 isozyme 2) (Cytochrome P450 LM2) (Cytochrome P450 type B0) (Cytochrome P450 type B1)	Oryctolagus cuniculus (Rabbit)	epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805]	arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005789; GO:0006805; GO:0008392; GO:0016712; GO:0019373; GO:0020037
GN021321	GN021321.1	Q64583	34.6	379	375	495	1.23e-57	198	CP2BF_RAT	Cytochrome P450 2B15 (EC 1.14.14.1) (CYPIIB15)	Rattus norvegicus (Rat)	epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805]	arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005737; GO:0005789; GO:0006805; GO:0008392; GO:0016712; GO:0019373; GO:0020037
GN021322	GN021322.1	Q64583	37.0	467	469	495	3.18e-89	283	CP2BF_RAT	Cytochrome P450 2B15 (EC 1.14.14.1) (CYPIIB15)	Rattus norvegicus (Rat)	epoxygenase P450 pathway [GO:0019373]; xenobiotic metabolic process [GO:0006805]	arachidonate epoxygenase activity [GO:0008392]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	GO:0005506; GO:0005737; GO:0005789; GO:0006805; GO:0008392; GO:0016712; GO:0019373; GO:0020037
GN021323	GN021323.1	O55071	35.8	472	475	492	2.50e-89	284	CP2BJ_MOUSE	Cytochrome P450 2B19 (EC 1.14.14.1) (CYPIIB19)	Mus musculus (Mouse)	epoxygenase P450 pathway [GO:0019373]; ketone metabolic process [GO:0042180]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	anandamide 11,12 epoxidase activity [GO:0062188]; anandamide 14,15 epoxidase activity [GO:0062189]; anandamide 8,9 epoxidase activity [GO:0062187]; arachidonate epoxygenase activity [GO:0008392]; estrogen 2-hydroxylase activity [GO:0101021]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; testosterone 16-alpha-hydroxylase activity [GO:0008390]; testosterone 16-beta-hydroxylase activity [GO:0062184]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	GO:0004497; GO:0005506; GO:0005737; GO:0005789; GO:0006805; GO:0008202; GO:0008390; GO:0008392; GO:0016712; GO:0019373; GO:0020037; GO:0042178; GO:0042180; GO:0062184; GO:0062187; GO:0062188; GO:0062189; GO:0101021
GN021324	GN021324.1	P10632	37.5	469	484	490	4.01e-100	312	CP2C8_HUMAN	Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase)	Homo sapiens (Human)	epoxygenase P450 pathway [GO:0019373]; estrogen metabolic process [GO:0008210]; icosanoid biosynthetic process [GO:0046456]; lipid hydroxylation [GO:0002933]; long-chain fatty acid biosynthetic process [GO:0042759]; omega-hydroxylase P450 pathway [GO:0097267]; oxidative demethylation [GO:0070989]; retinoic acid metabolic process [GO:0042573]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	arachidonate 11,12-epoxygenase activity [GO:0008405]; arachidonate 14,15-epoxygenase activity [GO:0008404]; arachidonate epoxygenase activity [GO:0008392]; caffeine oxidase activity [GO:0034875]; estrogen 16-alpha-hydroxylase activity [GO:0101020]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [GO:0016712]; retinoic acid 4-hydroxylase activity [GO:0008401]	cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]	GO:0002933; GO:0004497; GO:0005506; GO:0005737; GO:0005789; GO:0006805; GO:0008202; GO:0008210; GO:0008392; GO:0008401; GO:0008404; GO:0008405; GO:0016712; GO:0019373; GO:0020037; GO:0034875; GO:0042178; GO:0042572; GO:0042573; GO:0042759; GO:0046456; GO:0070989; GO:0097267; GO:0101020
GN021326	GN021326.1	Q9GUM7	36.4	118	165	143	4.05e-10	58.2	CPLX1_CAEEL	Putative complexin-1	Caenorhabditis elegans	modulation of chemical synaptic transmission [GO:0050804]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; synaptic vesicle exocytosis [GO:0016079]	SNARE binding [GO:0000149]	axon [GO:0030424]; cytosol [GO:0005829]; SNARE complex [GO:0031201]; synapse [GO:0045202]; terminal bouton [GO:0043195]	GO:0000149; GO:0005829; GO:0016079; GO:0030424; GO:0031201; GO:0031630; GO:0043195; GO:0045202; GO:0050804
GN021327	GN021327.1	Q04861	44.9	69	81	983	2.13e-10	58.2	NFKB1_CHICK	Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]	Gallus gallus (Chicken)	canonical NF-kappaB signal transduction [GO:0007249]; positive regulation of transcription by RNA polymerase II [GO:0045944]	DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; NF-kappaB binding [GO:0051059]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]	cytoplasm [GO:0005737]; NF-kappaB p50/p65 complex [GO:0035525]; nucleus [GO:0005634]	GO:0000978; GO:0000981; GO:0005634; GO:0005737; GO:0007249; GO:0035525; GO:0045944; GO:0051059
GN021329	GN021329.1	Q8N9V6	38.8	206	535	530	2.57e-19	94.7	ANR53_HUMAN	Ankyrin repeat domain-containing protein 53	Homo sapiens (Human)	mitotic metaphase chromosome alignment [GO:0007080]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cytokinesis [GO:1902412]; regulation of mitotic spindle organization [GO:0060236]		spindle [GO:0005819]; spindle pole [GO:0000922]	GO:0000922; GO:0005819; GO:0007080; GO:0031116; GO:0060236; GO:1902412
GN021330	GN021330.1	Q9TUP7	37.9	177	222	444	4.31e-22	96.7	OX2R_CANLF	Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2)	Canis lupus familiaris (Dog) (Canis familiaris)	cellular response to hormone stimulus [GO:0032870]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; glucose homeostasis [GO:0042593]; locomotion [GO:0040011]; neuropeptide signaling pathway [GO:0007218]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]	orexin receptor activity [GO:0016499]	plasma membrane [GO:0005886]	GO:0005886; GO:0007218; GO:0007631; GO:0010840; GO:0016499; GO:0022410; GO:0032870; GO:0040011; GO:0042593; GO:0051480
GN021332	GN021332.1	B5X8M4	64.8	250	263	260	4.29e-112	326	BRCC3_SALSA	Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)	Salmo salar (Atlantic salmon)	DNA repair-dependent chromatin remodeling [GO:0140861]; double-strand break repair [GO:0006302]; mitotic G2 DNA damage checkpoint signaling [GO:0007095]; positive regulation of DNA repair [GO:0045739]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; protein K63-linked deubiquitination [GO:0070536]; response to ionizing radiation [GO:0010212]	cysteine-type deubiquitinase activity [GO:0004843]; metal-dependent deubiquitinase activity [GO:0140492]; metallopeptidase activity [GO:0008237]; polyubiquitin modification-dependent protein binding [GO:0031593]	BRCA1-A complex [GO:0070531]; BRISC complex [GO:0070552]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle pole [GO:0000922]	GO:0000922; GO:0004843; GO:0005634; GO:0005737; GO:0006302; GO:0007095; GO:0008237; GO:0010212; GO:0031593; GO:0045739; GO:0070531; GO:0070536; GO:0070552; GO:0140492; GO:0140861; GO:1900227
GN021334	GN021334.1	Q8K194	61.8	68	146	155	1.13e-22	90.5	SNR27_MOUSE	U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (U4/U6.U5 tri-snRNP-associated protein 3)	Mus musculus (Mouse)	RNA splicing [GO:0008380]		precatalytic spliceosome [GO:0071011]; spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	GO:0005681; GO:0008380; GO:0046540; GO:0071011
GN021335	GN021335.1	H3BCW1	41.6	296	300	356	1.25e-59	197	ADPRS_LATCH	ADP-ribosylhydrolase ARH3 (ADP-ribose glycohydrolase ARH3) (LchARH3) (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-)	Latimeria chalumnae (Coelacanth)	negative regulation of necroptotic process [GO:0060546]; peptidyl-serine ADP-deribosylation [GO:0140290]	ADP-ribosylserine-[protein] hydrolase activity [GO:0140292]; magnesium ion binding [GO:0000287]; poly(ADP-ribose) glycohydrolase activity [GO:0004649]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]	GO:0000287; GO:0004649; GO:0005634; GO:0005694; GO:0005737; GO:0005759; GO:0060546; GO:0140290; GO:0140292
GN021336	GN021336.1	Q1JQD6	25.5	419	641	590	3.65e-18	92.0	TAF1B_BOVIN	TATA box-binding protein-associated factor RNA polymerase I subunit B (RNA polymerase I-specific TBP-associated factor 63 kDa) (TAFI63) (TATA box-binding protein-associated factor 1B) (TBP-associated factor 1B) (Transcription initiation factor SL1/TIF-IB subunit B)	Bos taurus (Bovine)	nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; RNA polymerase I preinitiation complex assembly [GO:0001188]	RNA polymerase I core promoter sequence-specific DNA binding [GO:0001164]	RNA polymerase I core factor complex [GO:0070860]; RNA polymerase transcription factor SL1 complex [GO:0005668]	GO:0001164; GO:0001188; GO:0005668; GO:0042790; GO:0070860
GN021338	GN021338.1	Q2TBN6	58.7	155	156	408	1.63e-63	202	PCID2_BOVIN	PCI domain-containing protein 2 (CSN12-like protein)	Bos taurus (Bovine)	negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of lymphoid progenitor cell differentiation [GO:1905457]; poly(A)+ mRNA export from nucleus [GO:0016973]; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; spleen development [GO:0048536]; transcription elongation by RNA polymerase II [GO:0006368]	double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear pore nuclear basket [GO:0044615]; nucleus [GO:0005634]; transcription export complex 2 [GO:0070390]	GO:0000973; GO:0003690; GO:0003723; GO:0005634; GO:0005737; GO:0005829; GO:0006368; GO:0016973; GO:0044615; GO:0045814; GO:0048536; GO:0070390; GO:1905457
GN021339	GN021339.1	Q17LW0	36.4	1210	1325	2163	7.17e-239	748	MYO7A_AEDAE	Myosin-VIIa (Protein crinkled)	Aedes aegypti (Yellowfever mosquito) (Culex aegypti)	actin filament-based movement [GO:0030048]; antennal morphogenesis [GO:0048800]; chaeta morphogenesis [GO:0008407]; imaginal disc-derived wing hair organization [GO:0035317]; sensory perception of sound [GO:0007605]	ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; myosin light chain binding [GO:0032027]	apical part of cell [GO:0045177]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; microvillus [GO:0005902]; unconventional myosin complex [GO:0016461]	GO:0000146; GO:0005524; GO:0005737; GO:0005902; GO:0007605; GO:0008407; GO:0016461; GO:0030048; GO:0032027; GO:0035317; GO:0045177; GO:0048800; GO:0071944
GN021340	GN021340.1	Q8K2K6	47.3	258	670	561	7.17e-59	211	AGFG1_MOUSE	Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein homolog) (Nucleoporin-like protein RIP)	Mus musculus (Mouse)	acrosome assembly [GO:0001675]; intermediate filament organization [GO:0045109]; spermatid nucleus differentiation [GO:0007289]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]	GO:0001675; GO:0005096; GO:0005634; GO:0005737; GO:0007289; GO:0031410; GO:0043025; GO:0045109
GN021341	GN021341.1	O43657	38.8	224	768	245	1.66e-48	174	TSN6_HUMAN	Tetraspanin-6 (Tspan-6) (A15 homolog) (Putative NF-kappa-B-activating protein 321) (T245 protein) (Tetraspanin TM4-D) (Transmembrane 4 superfamily member 6)	Homo sapiens (Human)	negative regulation of canonical NF-kappaB signal transduction [GO:0043124]; negative regulation of cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]		extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]	GO:0005886; GO:0039532; GO:0043123; GO:0043124; GO:0070062
GN021342	GN021342.1	O35379	38.9	899	945	1528	1.07e-184	577	MRP1_MOUSE	ATP-binding cassette sub-family C member 1 (EC 7.6.2.-) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) (Multidrug resistance-associated protein 1) (EC 7.6.2.2)	Mus musculus (Mouse)	amygdala development [GO:0021764]; amyloid-beta clearance [GO:0097242]; amyloid-beta metabolic process [GO:0050435]; antigen processing and presentation of lipid antigen via MHC class Ib [GO:0048003]; apoptotic process [GO:0006915]; astrocyte differentiation [GO:0048708]; bilirubin transport [GO:0015723]; blood vessel diameter maintenance [GO:0097746]; carboxylic acid transmembrane transport [GO:1905039]; cell chemotaxis [GO:0060326]; cell redox homeostasis [GO:0045454]; cellular response to amyloid-beta [GO:1904646]; cellular response to type II interferon [GO:0071346]; cobalamin transport [GO:0015889]; cyclic nucleotide transport [GO:0070729]; defense response to Gram-positive bacterium [GO:0050830]; DNA damage response [GO:0006974]; endothelial cell apoptotic process [GO:0072577]; endothelium development [GO:0003158]; exploration behavior [GO:0035640]; export across plasma membrane [GO:0140115]; export from cell [GO:0140352]; fibroblast apoptotic process [GO:0044346]; gene expression [GO:0010467]; glial cell differentiation [GO:0010001]; glucocorticoid metabolic process [GO:0008211]; glutathione metabolic process [GO:0006749]; glutathione transmembrane transport [GO:0034775]; glutathione transport [GO:0034635]; granuloma formation [GO:0002432]; hippocampus development [GO:0021766]; hydrogen peroxide biosynthetic process [GO:0050665]; immune response [GO:0006955]; inflammatory response [GO:0006954]; inflammatory response to antigenic stimulus [GO:0002437]; intracellular chemical homeostasis [GO:0055082]; intracellular nitrogen homeostasis [GO:0141067]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; long-chain fatty acid import across plasma membrane [GO:0015911]; lymphocyte migration [GO:0072676]; macrophage activation [GO:0042116]; memory [GO:0007613]; multicellular organism growth [GO:0035264]; neural tissue regeneration [GO:0097719]; neurogenesis [GO:0022008]; NK T cell activation [GO:0051132]; phospholipid efflux [GO:0033700]; phospholipid translocation [GO:0045332]; pigment accumulation [GO:0043476]; positive regulation of cell migration [GO:0030335]; positive regulation of inflammatory response [GO:0050729]; protein localization to cell surface [GO:0034394]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of catalytic activity [GO:0050790]; regulation of cellular response to drug [GO:2001038]; regulation of membrane potential [GO:0042391]; response to fluid shear stress [GO:0034405]; response to glucocorticoid [GO:0051384]; response to oxidative stress [GO:0006979]; response to toxic substance [GO:0009636]; response to type II interferon [GO:0034341]; response to xenobiotic stimulus [GO:0009410]; sphingolipid translocation [GO:0099039]; superoxide anion generation [GO:0042554]; tetrahydrobiopterin metabolic process [GO:0046146]; tissue homeostasis [GO:0001894]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; vasodilation [GO:0042311]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transmembrane transport [GO:0006855]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type vitamin B12 transporter activity [GO:0015420]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; carboxylic acid transmembrane transporter activity [GO:0046943]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; long-chain fatty acid transmembrane transporter activity [GO:0005324]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]	GO:0001894; GO:0002432; GO:0002437; GO:0003158; GO:0005324; GO:0005524; GO:0005886; GO:0006691; GO:0006749; GO:0006855; GO:0006915; GO:0006954; GO:0006955; GO:0006974; GO:0006979; GO:0007613; GO:0008211; GO:0008559; GO:0009410; GO:0009636; GO:0009925; GO:0010001; GO:0010467; GO:0015420; GO:0015431; GO:0015562; GO:0015723; GO:0015889; GO:0015911; GO:0016323; GO:0016324; GO:0016328; GO:0016887; GO:0019370; GO:0021764; GO:0021766; GO:0022008; GO:0022857; GO:0030054; GO:0030335; GO:0033700; GO:0034040; GO:0034341; GO:0034394; GO:0034405; GO:0034634; GO:0034635; GO:0034775; GO:0035264; GO:0035640; GO:0042116; GO:0042311; GO:0042391; GO:0042554; GO:0042908; GO:0042910; GO:0043476; GO:0044346; GO:0045332; GO:0045454; GO:0046146; GO:0046943; GO:0048003; GO:0048708; GO:0050435; GO:0050665; GO:0050729; GO:0050790; GO:0050830; GO:0051132; GO:0051384; GO:0055082; GO:0055085; GO:0060326; GO:0070633; GO:0070729; GO:0071346; GO:0071716; GO:0072577; GO:0072676; GO:0097242; GO:0097719; GO:0097746; GO:0099039; GO:0140115; GO:0140352; GO:0140359; GO:0141067; GO:1903409; GO:1904646; GO:1905039; GO:1990961; GO:1990962; GO:2001038
GN021343	GN021343.1	P33527	59.1	394	397	1531	2.27e-148	460	MRP1_HUMAN	ATP-binding cassette sub-family C member 1 (EC 7.6.2.-) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) (Multidrug resistance-associated protein 1) (EC 7.6.2.2)	Homo sapiens (Human)	carboxylic acid transmembrane transport [GO:1905039]; cell chemotaxis [GO:0060326]; cellular response to amyloid-beta [GO:1904646]; cellular response to oxidative stress [GO:0034599]; cobalamin transport [GO:0015889]; cyclic nucleotide transport [GO:0070729]; export across plasma membrane [GO:0140115]; glutathione transmembrane transport [GO:0034775]; heme catabolic process [GO:0042167]; leukotriene metabolic process [GO:0006691]; leukotriene transport [GO:0071716]; phospholipid translocation [GO:0045332]; positive regulation of inflammatory response [GO:0050729]; response to xenobiotic stimulus [GO:0009410]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid translocation [GO:0099039]; transepithelial transport [GO:0070633]; transmembrane transport [GO:0055085]; transport across blood-brain barrier [GO:0150104]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]; xenobiotic transport across blood-brain barrier [GO:1990962]	ABC-type glutathione S-conjugate transporter activity [GO:0015431]; ABC-type transporter activity [GO:0140359]; ABC-type vitamin B12 transporter activity [GO:0015420]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; carboxylic acid transmembrane transporter activity [GO:0046943]; efflux transmembrane transporter activity [GO:0015562]; glutathione transmembrane transporter activity [GO:0034634]; xenobiotic transmembrane transporter activity [GO:0042910]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell junction [GO:0030054]; extracellular exosome [GO:0070062]; lateral plasma membrane [GO:0016328]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005524; GO:0005886; GO:0006691; GO:0006805; GO:0008559; GO:0009410; GO:0009925; GO:0015420; GO:0015431; GO:0015562; GO:0015889; GO:0016020; GO:0016323; GO:0016324; GO:0016328; GO:0016887; GO:0030054; GO:0030148; GO:0034040; GO:0034599; GO:0034634; GO:0034775; GO:0042167; GO:0042626; GO:0042908; GO:0042910; GO:0045332; GO:0046943; GO:0050729; GO:0055085; GO:0060326; GO:0070062; GO:0070633; GO:0070729; GO:0071716; GO:0099039; GO:0140115; GO:0140359; GO:0150104; GO:1904646; GO:1905039; GO:1990962
GN021345	GN021345.1	P11584	24.5	188	520	846	6.32e-12	72.0	ITBX_DROME	Integrin beta-PS (Position-specific antigen beta subunit) (Protein myospheroid) (Protein olfactory C)	Drosophila melanogaster (Fruit fly)	actin filament organization [GO:0007015]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; calcium-dependent cell-cell adhesion [GO:0016339]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; central nervous system development [GO:0007417]; central nervous system morphogenesis [GO:0021551]; determination of adult lifespan [GO:0008340]; dorsal closure [GO:0007391]; dorsal trunk growth, open tracheal system [GO:0035001]; germ-band extension [GO:0007377]; germ-line stem cell population maintenance [GO:0030718]; heart morphogenesis [GO:0003007]; hemocyte migration [GO:0035099]; heterophilic cell-cell adhesion [GO:0007157]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing morphogenesis [GO:0007476]; integrin-mediated signaling pathway [GO:0007229]; larval heart development [GO:0007508]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; midgut development [GO:0007494]; muscle organ development [GO:0007517]; negative regulation of cell migration [GO:0030336]; positive regulation of synapse maturation [GO:0090129]; regulation of cell shape [GO:0008360]; regulation of stress fiber assembly [GO:0051492]; salivary gland development [GO:0007431]; sarcomere organization [GO:0045214]; sensory perception of smell [GO:0007608]; somatic muscle attachment to chitin-based cuticle [GO:0160175]; substrate adhesion-dependent cell spreading [GO:0034446]; substrate-dependent cell migration, cell extension [GO:0006930]; ventral cord development [GO:0007419]	integrin binding [GO:0005178]; protein heterodimerization activity [GO:0046982]; transmembrane signaling receptor activity [GO:0004888]	apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; costamere [GO:0043034]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; integrin complex [GO:0008305]; lateral plasma membrane [GO:0016328]; muscle tendon junction [GO:0005927]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]	GO:0003007; GO:0004888; GO:0005178; GO:0005886; GO:0005925; GO:0005927; GO:0006930; GO:0007015; GO:0007157; GO:0007160; GO:0007229; GO:0007298; GO:0007377; GO:0007391; GO:0007411; GO:0007417; GO:0007419; GO:0007431; GO:0007476; GO:0007494; GO:0007508; GO:0007517; GO:0007608; GO:0008305; GO:0008340; GO:0008360; GO:0009925; GO:0009986; GO:0016324; GO:0016328; GO:0016339; GO:0016477; GO:0021551; GO:0030336; GO:0030425; GO:0030718; GO:0031252; GO:0031589; GO:0033627; GO:0034446; GO:0035001; GO:0035099; GO:0035160; GO:0042734; GO:0043034; GO:0045211; GO:0045214; GO:0046982; GO:0048803; GO:0051492; GO:0090129; GO:0098609; GO:0160175
GN021349	GN021349.1	Q0V9W6	29.8	392	388	529	8.54e-45	165	BTBD6_XENTR	BTB/POZ domain-containing protein 6	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)			cytoplasm [GO:0005737]	GO:0005737
GN021351	GN021351.1	D6C652	39.0	490	458	459	3.28e-70	233	YAP1A_XENLA	Transcriptional coactivator YAP1-A (Yes-associated protein 1-A) (xYAP) (Protein yorkie homolog-A) (Yes-associated protein YAP65 homolog A)	Xenopus laevis (African clawed frog)	hippo signaling [GO:0035329]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of stem cell proliferation [GO:0072091]	transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0003713; GO:0003714; GO:0005634; GO:0005737; GO:0005886; GO:0005911; GO:0005923; GO:0035329; GO:0045944; GO:0050679; GO:0072091
GN021354	GN021354.1	B0WGM1	70.0	454	521	744	3.50e-224	639	EFGM_CULQU	Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1)	Culex quinquefasciatus (Southern house mosquito) (Culex pungens)	mitochondrial translational elongation [GO:0070125]	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]	mitochondrial matrix [GO:0005759]	GO:0003746; GO:0003924; GO:0005525; GO:0005759; GO:0070125
GN021355	GN021355.1	Q9ESX5	75.7	391	486	509	1.34e-221	622	DKC1_MOUSE	H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)	Mus musculus (Mouse)	box H/ACA sno(s)RNA 3'-end processing [GO:0000495]; box H/ACA sno(s)RNA metabolic process [GO:0033979]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; rRNA pseudouridine synthesis [GO:0031118]; scaRNA localization to Cajal body [GO:0090666]; snoRNA guided rRNA pseudouridine synthesis [GO:0000454]; snRNA pseudouridine synthesis [GO:0031120]; telomerase holoenzyme complex assembly [GO:1905323]; telomerase RNA stabilization [GO:0090669]; telomere maintenance via telomerase [GO:0007004]	box H/ACA snoRNA binding [GO:0034513]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034]	box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]	GO:0000454; GO:0000455; GO:0000495; GO:0001650; GO:0003720; GO:0003723; GO:0005634; GO:0005654; GO:0005697; GO:0005730; GO:0005737; GO:0007004; GO:0008284; GO:0009982; GO:0015030; GO:0031118; GO:0031120; GO:0031429; GO:0032212; GO:0033979; GO:0034513; GO:0070034; GO:0090661; GO:0090666; GO:0090669; GO:0120159; GO:1904872; GO:1904874; GO:1905323; GO:1990481
GN021356	GN021356.1	Q24732	87.5	32	425	598	9.18e-11	67.4	GLAS_DROVI	Protein glass	Drosophila virilis (Fruit fly)	regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]	nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0006355; GO:0006357
GN021357	GN021357.1	P28715	43.9	114	423	1186	1.43e-19	95.1	ERCC5_HUMAN	DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein)	Homo sapiens (Human)	base-excision repair, AP site formation [GO:0006285]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of apoptotic process [GO:0043066]; nucleotide-excision repair [GO:0006289]; response to UV [GO:0009411]; response to UV-C [GO:0010225]; transcription-coupled nucleotide-excision repair [GO:0006283]	bubble DNA binding [GO:0000405]; damaged DNA binding [GO:0003684]; DNA endonuclease activity [GO:0004520]; double-stranded DNA binding [GO:0003690]; endonuclease activity [GO:0004519]; enzyme activator activity [GO:0008047]; hydrolase activity, acting on ester bonds [GO:0016788]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; RNA polymerase II complex binding [GO:0000993]; single-stranded DNA binding [GO:0003697]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]	GO:0000109; GO:0000405; GO:0000724; GO:0000993; GO:0003684; GO:0003690; GO:0003697; GO:0004519; GO:0004520; GO:0005634; GO:0005654; GO:0005694; GO:0006283; GO:0006285; GO:0006289; GO:0008047; GO:0009411; GO:0010225; GO:0016788; GO:0032991; GO:0042803; GO:0043066; GO:0044877
GN021358	GN021358.1	Q9ESX5	76.2	319	323	509	4.11e-182	515	DKC1_MOUSE	H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)	Mus musculus (Mouse)	box H/ACA sno(s)RNA 3'-end processing [GO:0000495]; box H/ACA sno(s)RNA metabolic process [GO:0033979]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; rRNA pseudouridine synthesis [GO:0031118]; scaRNA localization to Cajal body [GO:0090666]; snoRNA guided rRNA pseudouridine synthesis [GO:0000454]; snRNA pseudouridine synthesis [GO:0031120]; telomerase holoenzyme complex assembly [GO:1905323]; telomerase RNA stabilization [GO:0090669]; telomere maintenance via telomerase [GO:0007004]	box H/ACA snoRNA binding [GO:0034513]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159]; telomerase activity [GO:0003720]; telomerase RNA binding [GO:0070034]	box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]	GO:0000454; GO:0000455; GO:0000495; GO:0001650; GO:0003720; GO:0003723; GO:0005634; GO:0005654; GO:0005697; GO:0005730; GO:0005737; GO:0007004; GO:0008284; GO:0009982; GO:0015030; GO:0031118; GO:0031120; GO:0031429; GO:0032212; GO:0033979; GO:0034513; GO:0070034; GO:0090661; GO:0090666; GO:0090669; GO:0120159; GO:1904872; GO:1904874; GO:1905323; GO:1990481
GN021359	GN021359.1	Q9ZRW8	36.2	199	227	219	2.85e-25	101	GSTUJ_ARATH	Glutathione S-transferase U19 (AtGSTU19) (EC 2.5.1.18) (GST class-tau member 19) (Glutathione S-transferase 8)	Arabidopsis thaliana (Mouse-ear cress)	cellular response to water deprivation [GO:0042631]; glutathione metabolic process [GO:0006749]; response to oxidative stress [GO:0006979]; toxin catabolic process [GO:0009407]	glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]	chloroplast [GO:0009507]; chloroplast stroma [GO:0009570]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; plant-type vacuole [GO:0000325]; plasma membrane [GO:0005886]	GO:0000325; GO:0004364; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006749; GO:0006979; GO:0009407; GO:0009507; GO:0009570; GO:0042631; GO:0043295
GN021360	GN021360.1	A2RU49	31.6	374	380	373	4.21e-54	186	HYKK_HUMAN	Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1)	Homo sapiens (Human)	L-lysine catabolic process [GO:0019477]	amino acid kinase activity [GO:0019202]; hydroxylysine kinase activity [GO:0047992]	mitochondrial matrix [GO:0005759]	GO:0005759; GO:0019202; GO:0019477; GO:0047992
GN021361	GN021361.1	Q9Y2H2	50.7	436	657	1132	6.14e-132	419	SAC2_HUMAN	Phosphatidylinositide 4-phosphatase SAC2 (EC 3.1.3.-) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2)	Homo sapiens (Human)	adult locomotory behavior [GO:0008344]; cardiac muscle hypertrophy in response to stress [GO:0014898]; clathrin-dependent endocytosis [GO:0072583]; negative regulation of axon regeneration [GO:0048681]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of receptor recycling [GO:0001921]; regulation of cell motility [GO:2000145]; regulation of endocytic recycling [GO:2001135]	inositol monophosphate 4-phosphatase activity [GO:0052833]; phosphatidylinositol phosphate 4-phosphatase activity [GO:0034596]; phosphatidylinositol phosphate 5-phosphatase activity [GO:0034595]; phosphatidylinositol-4-phosphate phosphatase activity [GO:0043812]; protein homodimerization activity [GO:0042803]	axon [GO:0030424]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; neuronal cell body [GO:0043025]; recycling endosome [GO:0055037]	GO:0001921; GO:0005769; GO:0005905; GO:0006661; GO:0008344; GO:0014898; GO:0030424; GO:0030425; GO:0031161; GO:0031901; GO:0034595; GO:0034596; GO:0042803; GO:0043025; GO:0043812; GO:0045334; GO:0046856; GO:0048681; GO:0052833; GO:0055037; GO:0072583; GO:2000145; GO:2001135
GN021362	GN021362.1	P24014	48.7	1266	1344	1504	1.04e-151	500	SLIT_DROME	Protein slit (dSlit) (Slit-FL) [Cleaved into: Protein slit N-product (Slit-N); Protein slit C-product (Slit-C)]	Drosophila melanogaster (Fruit fly)	axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; mesoderm migration involved in gastrulation [GO:0007509]; mesodermal cell migration [GO:0008078]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]; synaptic target inhibition [GO:0016201]	calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; Roundabout binding [GO:0048495]	axon [GO:0030424]; cell surface [GO:0009986]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; Slit-Robo signaling complex [GO:0071666]	GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0009986; GO:0010632; GO:0016199; GO:0016201; GO:0022409; GO:0030182; GO:0030335; GO:0030424; GO:0035050; GO:0035385; GO:0048495; GO:0048813; GO:0050929; GO:0071666; GO:2000274
GN021364	GN021364.1	P49016	28.9	159	239	252	9.05e-09	57.8	MENG_LACLA	Demethylmenaquinone methyltransferase (EC 2.1.1.163)	Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)	menaquinone biosynthetic process [GO:0009234]	demethylmenaquinone methyltransferase activity [GO:0043770]		GO:0009234; GO:0043770
GN021367	GN021367.1	F7AEX0	35.5	839	1652	743	9.79e-122	404	UVSSA_XENTR	UV-stimulated scaffold protein A	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	protein ubiquitination [GO:0016567]; response to UV [GO:0009411]; transcription-coupled nucleotide-excision repair [GO:0006283]	chromatin-protein adaptor activity [GO:0140463]; RNA polymerase II complex binding [GO:0000993]; RNA polymerase inhibitor activity [GO:0140870]	chromosome [GO:0005694]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]	GO:0000993; GO:0005634; GO:0005694; GO:0006283; GO:0009411; GO:0016567; GO:0090734; GO:0140463; GO:0140870
GN021368	GN021368.1	Q9JID1	51.1	415	448	469	2.13e-125	375	PDCD4_RAT	Programmed cell death protein 4 (Death up-regulated gene protein)	Rattus norvegicus (Rat)	BMP signaling pathway [GO:0030509]; cellular response to lipopolysaccharide [GO:0071222]; epithelial to mesenchymal transition involved in cardiac fibroblast development [GO:0060940]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of vascular associated smooth muscle cell differentiation [GO:1905064]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of inflammatory response [GO:0050729]; positive regulation of non-canonical NF-kappaB signal transduction [GO:1901224]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; regulation of protein metabolic process [GO:0051246]; response to alkaloid [GO:0043279]; response to hormone [GO:0009725]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005634; GO:0005737; GO:0005829; GO:0009725; GO:0030509; GO:0034393; GO:0043066; GO:0043279; GO:0043508; GO:0045892; GO:0050729; GO:0051246; GO:0060940; GO:0071222; GO:1900016; GO:1901224; GO:1904706; GO:1904761; GO:1905064; GO:1905461; GO:2000353
GN021369	GN021369.1	Q9BVG4	59.2	142	169	233	1.65e-56	180	PBDC1_HUMAN	Protein PBDC1 (Polysaccharide biosynthesis domain-containing protein 1)	Homo sapiens (Human)	'de novo' cotranslational protein folding [GO:0051083]	protein folding chaperone [GO:0044183]		GO:0044183; GO:0051083
GN021370	GN021370.1	A5PLK2	58.0	231	251	270	2.44e-91	273	LHPP_DANRE	Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (EC 3.1.3.-) (EC 3.6.1.1)	Danio rerio (Zebrafish) (Brachydanio rerio)	phosphate-containing compound metabolic process [GO:0006796]	inorganic diphosphate phosphatase activity [GO:0004427]; phosphatase activity [GO:0016791]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0004427; GO:0005634; GO:0005829; GO:0006796; GO:0016791
GN021374	GN021374.1	O35382	42.5	990	968	975	2.26e-234	691	EXOC4_MOUSE	Exocyst complex component 4 (Exocyst complex component Sec8)	Mus musculus (Mouse)	chemical synaptic transmission [GO:0007268]; cilium assembly [GO:0060271]; establishment of cell polarity [GO:0030010]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; membrane biogenesis [GO:0044091]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; oligodendrocyte differentiation [GO:0048709]; paraxial mesoderm formation [GO:0048341]; positive regulation of calcium-mediated signaling [GO:0050850]; protein localization to ciliary membrane [GO:1903441]; protein targeting to membrane [GO:0006612]; protein transmembrane transport [GO:0071806]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; regulation of protein transport [GO:0051223]; vesicle docking involved in exocytosis [GO:0006904]; vesicle tethering involved in exocytosis [GO:0090522]	GTP-dependent protein binding [GO:0030742]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]	cell leading edge [GO:0031252]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; endosome [GO:0005768]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone [GO:0030426]; growth cone membrane [GO:0032584]; microvillus [GO:0005902]; myelin sheath abaxonal region [GO:0035748]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic density, intracellular component [GO:0099092]; protein-containing complex [GO:0032991]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]	GO:0000145; GO:0000281; GO:0005737; GO:0005768; GO:0005813; GO:0005886; GO:0005902; GO:0006612; GO:0006887; GO:0006893; GO:0006904; GO:0007268; GO:0008021; GO:0014069; GO:0030010; GO:0030165; GO:0030425; GO:0030426; GO:0030742; GO:0031252; GO:0032584; GO:0032991; GO:0035748; GO:0043005; GO:0043025; GO:0043198; GO:0044091; GO:0044877; GO:0045202; GO:0048341; GO:0048709; GO:0050850; GO:0051223; GO:0060271; GO:0071806; GO:0090148; GO:0090522; GO:0090543; GO:0098685; GO:0098696; GO:0099092; GO:1903441
GN021375	GN021375.1	Q8NCK7	31.1	193	578	447	1.50e-14	79.7	MOT11_HUMAN	Monocarboxylate transporter 11 (MCT 11) (Solute carrier family 16 member 11)	Homo sapiens (Human)	lipid metabolic process [GO:0006629]	monocarboxylic acid transmembrane transporter activity [GO:0008028]; pyruvate transmembrane transporter activity [GO:0050833]	endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]	GO:0005789; GO:0005886; GO:0006629; GO:0008028; GO:0050833
GN021376	GN021376.1	Q0P5B7	33.7	181	225	399	2.00e-25	105	AAAD_BOVIN	Deacylase AADAC (EC 3.-.-.-) (50 kDa microsomal esterase/N-deacetylase) (Acetylesterase AADAC) (EC 3.1.1.6) (Arylacetamide deacetylase) (Arylalkyl acylamidase AADAC) (EC 3.5.1.76) (Diacylglycerol lipase activity AADAC) (EC 3.1.1.79)	Bos taurus (Bovine)	positive regulation of triglyceride catabolic process [GO:0010898]	serine hydrolase activity [GO:0017171]; triacylglycerol lipase activity [GO:0004806]	endoplasmic reticulum membrane [GO:0005789]	GO:0004806; GO:0005789; GO:0010898; GO:0017171
GN021377	GN021377.1	A4IHF8	57.8	166	167	203	4.91e-61	190	DPCD_XENTR	Protein DPCD	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)				
GN021378	GN021378.1	Q24JY4	49.2	130	170	154	1.64e-31	114	ZNHI1_BOVIN	Zinc finger HIT domain-containing protein 1 (p18 Hamlet)	Bos taurus (Bovine)	calcium ion homeostasis [GO:0055074]; chromatin remodeling [GO:0006338]; heart process [GO:0003015]; hematopoietic stem cell homeostasis [GO:0061484]; intestinal stem cell homeostasis [GO:0036335]; muscle cell differentiation [GO:0042692]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of lymphoid progenitor cell differentiation [GO:1905458]; positive regulation of transcription initiation by RNA polymerase II [GO:0060261]; transcription initiation-coupled chromatin remodeling [GO:0045815]	histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; nucleosome binding [GO:0031491]	nucleus [GO:0005634]	GO:0003015; GO:0005634; GO:0006338; GO:0031491; GO:0036335; GO:0042393; GO:0042692; GO:0042826; GO:0043517; GO:0045815; GO:0055074; GO:0060261; GO:0061484; GO:1905458
GN021380	GN021380.1	Q8N6F8	34.5	174	232	245	1.24e-28	111	MET27_HUMAN	Methyltransferase-like protein 27 (Williams-Beuren syndrome chromosomal region 27 protein)	Homo sapiens (Human)				
GN021381	GN021381.1	Q96IR7	32.8	405	417	371	1.34e-49	175	HPDL_HUMAN	4-hydroxyphenylpyruvate dioxygenase-like protein (HPD-like protein) (HPDL) (EC 1.13.11.46) (Glyoxalase domain-containing protein 1)	Homo sapiens (Human)	aromatic amino acid metabolic process [GO:0009072]	4-hydroxymandelate synthase activity [GO:0050585]; 4-hydroxyphenylpyruvate dioxygenase activity [GO:0003868]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003868; GO:0005739; GO:0005759; GO:0009072; GO:0050585
GN021382	GN021382.1	B1H2T2	41.3	429	473	429	3.61e-97	302	DIK2A_XENTR	Divergent protein kinase domain 2A (Deleted in autism protein 1 homolog)	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	cardiac muscle cell proliferation [GO:0060038]; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051896]		COPI vesicle coat [GO:0030126]; extracellular region [GO:0005576]	GO:0005576; GO:0030126; GO:0051896; GO:0060038
GN021384	GN021384.1	Q5SQY2	51.9	104	1526	173	1.09e-29	120	BOD1_MOUSE	Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B)	Mus musculus (Mouse)		protein phosphatase 2A binding [GO:0051721]; protein phosphatase inhibitor activity [GO:0004864]	centrosome [GO:0005813]; outer kinetochore [GO:0000940]; Set1C/COMPASS complex [GO:0048188]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]	GO:0000922; GO:0000940; GO:0004864; GO:0005813; GO:0005876; GO:0048188; GO:0051721
GN021386	GN021386.1	Q32TG3	52.6	747	745	746	4.17e-278	786	EFHC2_CHICK	EF-hand domain-containing family member C2	Gallus gallus (Chicken)	regulation of dendrite morphogenesis [GO:0048814]		axonemal microtubule [GO:0005879]	GO:0005879; GO:0048814
GN021388	GN021388.1	Q9BX73	60.5	157	215	214	2.03e-70	216	TM2D2_HUMAN	TM2 domain-containing protein 2 (Beta-amyloid-binding protein-like protein 1) (BBP-like protein 1)	Homo sapiens (Human)			membrane [GO:0016020]	GO:0016020
GN021391	GN021391.1	Q9Y115	31.8	449	733	538	5.55e-65	228	UN93L_DROME	UNC93-like protein	Drosophila melanogaster (Fruit fly)	inorganic ion homeostasis [GO:0098771]; regulation of muscle contraction [GO:0006937]; regulation of potassium ion transport [GO:0043266]; renal system process [GO:0003014]; transmembrane transport [GO:0055085]	potassium channel regulator activity [GO:0015459]; transmembrane transporter activity [GO:0022857]	membrane [GO:0016020]; plasma membrane [GO:0005886]; striated muscle dense body [GO:0055120]	GO:0003014; GO:0005886; GO:0006937; GO:0015459; GO:0016020; GO:0022857; GO:0043266; GO:0055085; GO:0055120; GO:0098771
GN021393	GN021393.1	E9PVX6	51.4	109	2004	3177	3.17e-22	109	KI67_MOUSE	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67 homolog) (Antigen KI-67 homolog) (Antigen Ki67 homolog)	Mus musculus (Mouse)	cell population proliferation [GO:0008283]; cholangiocyte proliferation [GO:1990705]; chromosome segregation [GO:0007059]; epithelial cell proliferation [GO:0050673]; hepatocyte proliferation [GO:0072574]; meiotic cell cycle [GO:0051321]; regulation of chromatin organization [GO:1902275]; regulation of mitotic nuclear division [GO:0007088]	molecular condensate scaffold activity [GO:0140693]; RNA binding [GO:0003723]	chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000775; GO:0000793; GO:0003723; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0007059; GO:0007088; GO:0008283; GO:0050673; GO:0051321; GO:0072574; GO:0140693; GO:1902275; GO:1990705
GN021394	GN021394.1	Q05B50	60.2	274	275	298	1.16e-121	352	THG1_BOVIN	Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (tRNA-histidine guanylyltransferase)	Bos taurus (Bovine)	response to oxidative stress [GO:0006979]; stress-induced mitochondrial fusion [GO:1990046]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033]	magnesium ion binding [GO:0000287]; tRNA guanylyltransferase activity [GO:0008193]	mitochondrion [GO:0005739]	GO:0000287; GO:0005739; GO:0006400; GO:0006979; GO:0008033; GO:0008193; GO:1990046
GN021397	GN021397.1	A0A7J6K629	30.4	217	586	547	1.03e-16	87.0	TGPC1_TOXGO	Apicoplast pyruvate carrier 1 (APC1) (Apicoplast monocarboxylate transporter 1) (AMT1) (Hypothetical apicoplast protein 3) (HAP3)	Toxoplasma gondii	amino acid transmembrane transport [GO:0003333]; pyruvate transmembrane transport [GO:1901475]	transmembrane transporter activity [GO:0022857]	apicoplast membrane [GO:0160211]	GO:0003333; GO:0022857; GO:0160211; GO:1901475
GN021398	GN021398.1	O75762	31.3	147	256	1119	2.74e-09	60.8	TRPA1_HUMAN	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor)	Homo sapiens (Human)	calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to caffeine [GO:0071313]; cellular response to carbon dioxide [GO:0071244]; cellular response to cold [GO:0070417]; cellular response to food [GO:0071240]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to toxic substance [GO:0097237]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transport [GO:0006811]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of monoatomic anion transport [GO:1903793]; protein homotetramerization [GO:0051289]; regulation of blood circulation [GO:1903522]; regulation of neuronal action potential [GO:0098908]; response to cold [GO:0009409]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]; ureteric peristalsis [GO:0072105]; urinary bladder smooth muscle contraction [GO:0014832]; vasodilation [GO:0042311]	calcium channel activity [GO:0005262]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]; temperature-gated cation channel activity [GO:0097604]; voltage-gated calcium channel activity [GO:0005245]	apical plasma membrane [GO:0016324]; axon [GO:0030424]; plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]	GO:0005245; GO:0005262; GO:0005886; GO:0006811; GO:0006874; GO:0007166; GO:0009409; GO:0014832; GO:0015267; GO:0015278; GO:0016324; GO:0019233; GO:0030424; GO:0032421; GO:0034605; GO:0035774; GO:0042311; GO:0042802; GO:0050955; GO:0050968; GO:0050974; GO:0051289; GO:0070301; GO:0070417; GO:0070588; GO:0071240; GO:0071244; GO:0071313; GO:0072105; GO:0097237; GO:0097553; GO:0097604; GO:0098908; GO:1903522; GO:1903793; GO:1990760
GN021399	GN021399.1	Q0P5C0	51.8	542	543	561	8.47e-204	582	LMF1_BOVIN	Lipase maturation factor 1 (Transmembrane protein 112)	Bos taurus (Bovine)	protein maturation [GO:0051604]; triglyceride metabolic process [GO:0006641]		endoplasmic reticulum membrane [GO:0005789]	GO:0005789; GO:0006641; GO:0051604
GN021405	GN021405.1	P36633	38.7	698	837	746	1.35e-165	501	AOC1_RAT	Diamine oxidase [copper-containing] (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase)	Rattus norvegicus (Rat)	putrescine metabolic process [GO:0009445]	calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; diamine oxidase activity [GO:0052597]; heparin binding [GO:0008201]; histamine oxidase activity [GO:0052598]; primary methylamine oxidase activity [GO:0008131]; protein homodimerization activity [GO:0042803]; putrescine oxidase activity [GO:0050232]; quinone binding [GO:0048038]	bicellular tight junction [GO:0005923]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0005507; GO:0005509; GO:0005576; GO:0005886; GO:0005923; GO:0008131; GO:0008201; GO:0009445; GO:0042803; GO:0048038; GO:0050232; GO:0052597; GO:0052598; GO:0070062
GN021406	GN021406.1	Q3UVX5	55.2	286	954	1203	1.23e-87	308	GRM5_MOUSE	Metabotropic glutamate receptor 5 (mGluR5)	Mus musculus (Mouse)	associative learning [GO:0008306]; cellular response to amyloid-beta [GO:1904646]; chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; conditioned place preference [GO:1990708]; desensitization of G protein-coupled receptor signaling pathway [GO:0002029]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotory behavior [GO:0007626]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of excitatory postsynaptic potential [GO:0090394]; operant conditioning [GO:0035106]; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cellular response to hypoxia [GO:1900039]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of sensory perception of pain [GO:1904058]; protein localization to nuclear inner membrane [GO:0036228]; protein phosphorylation [GO:0006468]; regulation of DNA-templated transcription [GO:0006355]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of long-term synaptic depression [GO:1900452]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of hot stimulus [GO:0062036]; synapse organization [GO:0050808]; temperature homeostasis [GO:0001659]	A2A adenosine receptor binding [GO:0031687]; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [GO:0001640]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [GO:0099530]; glutamate receptor activity [GO:0008066]; identical protein binding [GO:0042802]; PLC activating G protein-coupled glutamate receptor activity [GO:0001639]; protein tyrosine kinase activator activity [GO:0030296]; protein tyrosine kinase binding [GO:1990782]	astrocyte projection [GO:0097449]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; neuron spine [GO:0044309]; neuronal cell body [GO:0043025]; nuclear inner membrane [GO:0005637]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; Schaffer collateral - CA1 synapse [GO:0098685]	GO:0001639; GO:0001640; GO:0001659; GO:0002029; GO:0004930; GO:0005637; GO:0005737; GO:0005886; GO:0006355; GO:0006468; GO:0007204; GO:0007206; GO:0007216; GO:0007268; GO:0007611; GO:0007612; GO:0007626; GO:0008066; GO:0008306; GO:0030296; GO:0030425; GO:0031687; GO:0033603; GO:0035106; GO:0036228; GO:0042802; GO:0043005; GO:0043025; GO:0043197; GO:0043198; GO:0043410; GO:0044309; GO:0045211; GO:0048169; GO:0048170; GO:0050804; GO:0050808; GO:0050850; GO:0050890; GO:0051966; GO:0061002; GO:0062036; GO:0090394; GO:0097449; GO:0098685; GO:0098839; GO:0098978; GO:0099530; GO:1900039; GO:1900452; GO:1904058; GO:1904646; GO:1990708; GO:1990782; GO:2000179
GN021409	GN021409.1	Q9H8W3	38.1	105	224	233	2.65e-10	61.6	F204A_HUMAN	Protein FAM204A	Homo sapiens (Human)				
GN021413	GN021413.1	Q60HD5	32.8	457	448	477	5.99e-57	198	PPOX_MACFA	Protoporphyrinogen oxidase (PPO) (EC 1.3.3.4)	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	heme B biosynthetic process [GO:0006785]; heme biosynthetic process [GO:0006783]; porphyrin-containing compound biosynthetic process [GO:0006779]	protoporphyrinogen oxidase activity, oxygen as acceptor [GO:0004729]	mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]	GO:0004729; GO:0005743; GO:0005758; GO:0006779; GO:0006783; GO:0006785; GO:0031966
GN021418	GN021418.1	Q8VC85	66.7	114	133	133	8.38e-43	140	LSM1_MOUSE	U6 snRNA-associated Sm-like protein LSm1	Mus musculus (Mouse)	histone mRNA catabolic process [GO:0071044]; negative regulation of neuron differentiation [GO:0045665]; stem cell population maintenance [GO:0019827]	mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]	axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; Lsm1-7-Pat1 complex [GO:1990726]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]	GO:0000932; GO:0003729; GO:0005634; GO:0005737; GO:0019827; GO:0030424; GO:0030425; GO:0036002; GO:0043025; GO:0045665; GO:0071044; GO:1990726; GO:1990904
GN021420	GN021420.1	P62811	38.3	60	904	74	3.68e-09	57.4	WFD18_BOVIN	WAP four-disulfide core domain protein 18 (Extracellular peptidase inhibitor) (Protein WDNM1)	Bos taurus (Bovine)	antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]	GO:0004867; GO:0005576; GO:0019731; GO:0045087
GN021421	GN021421.1	P62811	43.1	58	97	74	4.46e-12	59.3	WFD18_BOVIN	WAP four-disulfide core domain protein 18 (Extracellular peptidase inhibitor) (Protein WDNM1)	Bos taurus (Bovine)	antibacterial humoral response [GO:0019731]; innate immune response [GO:0045087]	serine-type endopeptidase inhibitor activity [GO:0004867]	extracellular region [GO:0005576]	GO:0004867; GO:0005576; GO:0019731; GO:0045087
GN021422	GN021422.1	G5EGQ5	31.0	368	654	433	9.23e-22	102	MBR1_CAEEL	Mblk-1-related factor 1	Caenorhabditis elegans	regulation of transcription by RNA polymerase II [GO:0006357]	DNA binding [GO:0003677]	nucleus [GO:0005634]	GO:0003677; GO:0005634; GO:0006357
GN021423	GN021423.1	Q0VD26	74.1	139	145	146	3.48e-11	60.5	MORN4_BOVIN	MORN repeat-containing protein 4 (Retinophilin)	Bos taurus (Bovine)	response to axon injury [GO:0048678]		cytoplasm [GO:0005737]; filopodium tip [GO:0032433]; stereocilium tip [GO:0032426]	GO:0005737; GO:0032426; GO:0032433; GO:0048678
GN021424	GN021424.1	P19367	38.0	455	466	917	1.53e-93	305	HXK1_HUMAN	Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A)	Homo sapiens (Human)	canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; fructose 6-phosphate metabolic process [GO:0006002]; GDP-mannose biosynthetic process [GO:0009298]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; intracellular glucose homeostasis [GO:0001678]; maintenance of protein location in mitochondrion [GO:0072656]; mannose metabolic process [GO:0006013]; positive regulation of cytokine production involved in immune response [GO:0002720]; positive regulation of interleukin-1 beta production [GO:0032731]; protein localization to mitochondrion [GO:0070585]	ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; glucosamine kinase activity [GO:0047931]; hexokinase activity [GO:0004396]; mannokinase activity [GO:0019158]; peptidoglycan binding [GO:0042834]	cytosol [GO:0005829]; membrane raft [GO:0045121]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0001678; GO:0002720; GO:0004340; GO:0004396; GO:0005524; GO:0005536; GO:0005739; GO:0005741; GO:0005829; GO:0006002; GO:0006006; GO:0006013; GO:0006096; GO:0008865; GO:0009298; GO:0019158; GO:0032731; GO:0042834; GO:0045121; GO:0046835; GO:0047931; GO:0051156; GO:0061621; GO:0070585; GO:0072656
GN021425	GN021425.1	Q8IU80	26.8	261	259	811	2.16e-25	108	TMPS6_HUMAN	Transmembrane protease serine 6 (EC 3.4.21.-) (Matriptase-2)	Homo sapiens (Human)	collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; intracellular iron ion homeostasis [GO:0006879]; membrane protein proteolysis [GO:0033619]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein processing [GO:0016485]; self proteolysis [GO:0097264]	metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]	extracellular region [GO:0005576]; plasma membrane [GO:0005886]	GO:0000122; GO:0004222; GO:0004252; GO:0005576; GO:0005886; GO:0006879; GO:0008236; GO:0016485; GO:0022617; GO:0030574; GO:0033619; GO:0045892; GO:0045944; GO:0060586; GO:0097264
GN021426	GN021426.1	Q8C8H8	24.4	528	607	661	8.36e-36	146	KY_MOUSE	Kyphoscoliosis peptidase (EC 3.4.-.-)	Mus musculus (Mouse)	muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; Z disc [GO:0030018]	GO:0005737; GO:0005856; GO:0007517; GO:0007528; GO:0030018
GN021427	GN021427.1	Q6NUA7	34.5	203	274	456	2.17e-28	115	SIL1_XENLA	Nucleotide exchange factor SIL1	Xenopus laevis (African clawed frog)		adenyl-nucleotide exchange factor activity [GO:0000774]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	GO:0000774; GO:0005783; GO:0005788
GN021428	GN021428.1	Q6NUA7	50.7	71	149	456	3.83e-14	71.6	SIL1_XENLA	Nucleotide exchange factor SIL1	Xenopus laevis (African clawed frog)		adenyl-nucleotide exchange factor activity [GO:0000774]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	GO:0000774; GO:0005783; GO:0005788
GN021429	GN021429.1	Q9NFT7	47.8	446	503	486	1.19e-151	444	HXK2_DROME	Hexokinase-2 (EC 2.7.1.1) (Hexokinase testis)	Drosophila melanogaster (Fruit fly)	canonical glycolysis [GO:0061621]; intracellular glucose homeostasis [GO:0001678]	ATP binding [GO:0005524]; D-glucose binding [GO:0005536]; fructokinase activity [GO:0008865]; glucokinase activity [GO:0004340]; hexokinase activity [GO:0004396]; mannokinase activity [GO:0019158]	cytosol [GO:0005829]	GO:0001678; GO:0004340; GO:0004396; GO:0005524; GO:0005536; GO:0005829; GO:0008865; GO:0019158; GO:0061621
GN021431	GN021431.1	Q6NUA7	50.7	71	118	456	1.93e-14	71.2	SIL1_XENLA	Nucleotide exchange factor SIL1	Xenopus laevis (African clawed frog)		adenyl-nucleotide exchange factor activity [GO:0000774]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]	GO:0000774; GO:0005783; GO:0005788
GN021433	GN021433.1	Q64127	26.0	150	553	1051	6.59e-10	65.9	TIF1A_MOUSE	Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase Trim24) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)	Mus musculus (Mouse)	calcium ion homeostasis [GO:0055074]; cellular response to estrogen stimulus [GO:0071391]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of vitamin D receptor signaling pathway [GO:0070562]; response to peptide hormone [GO:0043434]	chromatin binding [GO:0003682]; estrogen response element binding [GO:0034056]; histone H3K23ac reader activity [GO:0140118]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein kinase activity [GO:0004672]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; euchromatin [GO:0000791]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]	GO:0000785; GO:0000791; GO:0002039; GO:0003682; GO:0003713; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005726; GO:0005737; GO:0005739; GO:0006468; GO:0008270; GO:0008285; GO:0010628; GO:0016567; GO:0016922; GO:0030163; GO:0031647; GO:0034056; GO:0042981; GO:0043434; GO:0043565; GO:0045892; GO:0045893; GO:0046777; GO:0055074; GO:0061630; GO:0070562; GO:0071391; GO:0140118; GO:1901796
GN021442	GN021442.1	A5WVX9	41.3	235	231	620	8.56e-60	201	ZDH17_DANRE	Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (Zinc finger DHHC domain-containing protein 17)	Danio rerio (Zebrafish) (Brachydanio rerio)	axonogenesis [GO:0007409]; habituation [GO:0046959]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]	protein-cysteine S-myristoyltransferase activity [GO:0019705]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; protein-cysteine S-stearoyltransferase activity [GO:0140439]	cytoplasmic vesicle membrane [GO:0030659]; Golgi membrane [GO:0000139]; presynaptic membrane [GO:0042734]	GO:0000139; GO:0007409; GO:0019705; GO:0019706; GO:0030659; GO:0042734; GO:0046959; GO:0051386; GO:0070372; GO:0140439