Annotation Cluster 1 Enrichment Score: 1.740645261718844 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011042:Six-bladed beta-propeller, TolB-like 8 0.8743169398907104 4.103605693951225E-4 O75382, D2GXS7, Q9U489, O75581, Q9R1R2, O70277, P55884, A4IF63 166 15 1556 4.999196787148595 0.14721906249308547 0.07653861071135493 0.5683315759520302 INTERPRO IPR013017:NHL repeat, subgroup 6 0.6557377049180327 5.431780343369844E-4 O75382, D2GXS7, Q9U489, Q9R1R2, O70277, A4IF63 166 8 1556 7.030120481927711 0.1900723337906819 0.06785799692944539 0.7516349619637874 INTERPRO IPR017868:Filamin/ABP280 repeat-like 6 0.6557377049180327 5.431780343369844E-4 O75382, D2GXS7, Q9U489, Q9R1R2, O70277, A4IF63 166 8 1556 7.030120481927711 0.1900723337906819 0.06785799692944539 0.7516349619637874 INTERPRO IPR001298:Filamin/ABP280 repeat 6 0.6557377049180327 5.431780343369844E-4 O75382, D2GXS7, Q9U489, Q9R1R2, O70277, A4IF63 166 8 1556 7.030120481927711 0.1900723337906819 0.06785799692944539 0.7516349619637874 INTERPRO IPR001258:NHL repeat 6 0.6557377049180327 5.431780343369844E-4 O75382, D2GXS7, Q9U489, Q9R1R2, O70277, A4IF63 166 8 1556 7.030120481927711 0.1900723337906819 0.06785799692944539 0.7516349619637874 INTERPRO IPR003649:B-box, C-terminal 6 0.6557377049180327 0.001117781083322545 O75382, D2GXS7, Q9U489, Q9R1R2, O70277, A4IF63 166 9 1556 6.2489959839357425 0.3520499256859101 0.1028080133206607 1.5410461741299897 SMART SM00557:IG_FLMN 6 0.6557377049180327 0.001658998189978782 O75382, D2GXS7, Q9U489, Q9R1R2, O70277, A4IF63 114 8 836 5.5 0.1860746343476073 0.1860746343476073 1.8990453669287644 INTERPRO IPR014756:Immunoglobulin E-set 7 0.7650273224043715 0.0028781937705945476 O75382, D2GXS7, Q9U489, Q04446, Q9R1R2, O70277, A4IF63 166 15 1556 4.37429718875502 0.6731811931761212 0.17005144458370813 3.92344490402996 SMART SM00502:BBC 6 0.6557377049180327 0.003331585545678828 O75382, D2GXS7, Q9U489, Q9R1R2, O70277, A4IF63 114 9 836 4.888888888888888 0.33887100481901433 0.18690160793358734 3.7802461085780226 UP_SEQ_FEATURE repeat:Filamin 4 0.4371584699453552 0.009319147728729379 O75382, Q9U489, Q9R1R2, O70277 151 5 1448 7.671523178807948 0.999369222376493 0.9142385544093402 13.36017514326352 UP_SEQ_FEATURE repeat:NHL 6 4 0.4371584699453552 0.009319147728729379 O75382, Q9U489, Q9R1R2, O70277 151 5 1448 7.671523178807948 0.999369222376493 0.9142385544093402 13.36017514326352 INTERPRO IPR000315:Zinc finger, B-box 6 0.6557377049180327 0.015667739335819175 O75382, D2GXS7, Q9U489, Q9R1R2, O70277, A4IF63 166 15 1556 3.7493975903614456 0.997817335611056 0.458125522216553 19.690968045953237 UP_SEQ_FEATURE repeat:NHL 1 4 0.4371584699453552 0.017230526098463157 O75382, Q9U489, Q9R1R2, O70277 151 6 1448 6.3929359823399565 0.999998853286157 0.8976920986881805 23.37295199508035 UP_SEQ_FEATURE repeat:NHL 2 4 0.4371584699453552 0.017230526098463157 O75382, Q9U489, Q9R1R2, O70277 151 6 1448 6.3929359823399565 0.999998853286157 0.8976920986881805 23.37295199508035 UP_SEQ_FEATURE repeat:NHL 4 4 0.4371584699453552 0.017230526098463157 O75382, Q9U489, Q9R1R2, O70277 151 6 1448 6.3929359823399565 0.999998853286157 0.8976920986881805 23.37295199508035 UP_SEQ_FEATURE repeat:NHL 3 4 0.4371584699453552 0.017230526098463157 O75382, Q9U489, Q9R1R2, O70277 151 6 1448 6.3929359823399565 0.999998853286157 0.8976920986881805 23.37295199508035 UP_SEQ_FEATURE repeat:NHL 5 4 0.4371584699453552 0.017230526098463157 O75382, Q9U489, Q9R1R2, O70277 151 6 1448 6.3929359823399565 0.999998853286157 0.8976920986881805 23.37295199508035 GOTERM_MF_DIRECT GO:0061630~ubiquitin protein ligase activity 7 0.7650273224043715 0.017692849885900273 O75382, Q80Z37, Q86Y13, Q9R1R2, O70277, P58283, Q9D787 152 20 1357 3.124671052631579 0.9955235525677568 0.8351921743679032 21.251300774071325 INTERPRO IPR027370:RING-type zinc-finger, LisH dimerisation motif 5 0.546448087431694 0.022161090603500525 O75382, D2GXS7, Q9R1R2, O70277, A4IF63 166 11 1556 4.260679079956189 0.9998326144445214 0.487708951245705 26.742891614903495 UP_SEQ_FEATURE zinc finger region:B box-type 3 0.32786885245901637 0.029817309324220123 O75382, Q9R1R2, O70277 151 3 1448 9.589403973509935 0.9999999999549471 0.8853354279975504 37.10219710971153 UP_SEQ_FEATURE chain:Tripartite motif-containing protein 3 3 0.32786885245901637 0.029817309324220123 O75382, Q9R1R2, O70277 151 3 1448 9.589403973509935 0.9999999999549471 0.8853354279975504 37.10219710971153 SMART SM00336:BBOX 6 0.6557377049180327 0.030140978424968465 O75382, D2GXS7, Q9U489, Q9R1R2, O70277, A4IF63 114 14 836 3.1428571428571423 0.9775163077646426 0.531862397769157 29.770675858425456 UP_SEQ_FEATURE zinc finger region:RING-type 6 0.6557377049180327 0.09400347432893319 O75382, Q80Z37, Q9U489, A9JTP3, Q9R1R2, O70277 151 24 1448 2.3973509933774837 1.0 0.992216744188307 77.95513964652308 INTERPRO IPR017907:Zinc finger, RING-type, conserved site 6 0.6557377049180327 0.10178076475309154 O75382, Q80Z37, D2GXS7, Q9R1R2, O70277, A4IF63 166 24 1556 2.3433734939759034 1.0 0.8236611473062527 77.47540426414545 INTERPRO IPR013083:Zinc finger, RING/FYVE/PHD-type 11 1.2021857923497268 0.10339317492109655 O75382, P0C8Z3, Q80Z37, Q86Y13, Q8WYB5, D2GXS7, Q6VNB8, Q9R1R2, O70277, A4IF63, Q9D787 166 61 1556 1.6903021923760617 1.0 0.8038101190951077 78.0304360386885 INTERPRO IPR001841:Zinc finger, RING-type 8 0.8743169398907104 0.1355332181905657 O75382, Q80Z37, Q86Y13, D2GXS7, A9JTP3, Q9R1R2, O70277, A4IF63 166 41 1556 1.8289744343226566 1.0 0.8575258729243258 86.76655183521405 SMART SM00184:RING 8 0.8743169398907104 0.16298747921868717 O75382, Q80Z37, Q86Y13, D2GXS7, A9JTP3, Q9R1R2, O70277, A4IF63 114 34 836 1.7254901960784315 0.9999999997377217 0.8898774556405381 87.18401507015534 GOTERM_CC_DIRECT GO:0005769~early endosome 5 0.546448087431694 0.1960311675769131 O75382, Q5VV43, O75581, Q9R1R2, O70277 157 22 1477 2.1381007527504345 1.0 0.9960244850695075 93.87901588552742 UP_KEYWORDS Endosome 8 0.8743169398907104 0.27295116865112834 O75382, Q8CI95, Q5VV43, F1Q506, Q9R1R2, O70277, Q8K4K5, A1A4L0 172 50 1616 1.5032558139534884 1.0 0.8468197446147845 98.19512631395149 UP_KEYWORDS Protein transport 11 1.2021857923497268 0.29242564523234016 O95487, O75382, Q9UGM3, F1Q506, O75694, Q5F3X8, P53992, Q9D8L5, Q9R1R2, O70277, A1A4L0 172 77 1616 1.3421926910299005 1.0 0.846677263937329 98.71785403304656 GOTERM_BP_DIRECT GO:0016567~protein ubiquitination 8 0.8743169398907104 0.2971948335777783 Q12829, Q96EB6, O75382, Q9R1R2, O70277, Q6TFL4, A4IF63, Q9D787 158 49 1414 1.4611211573236889 1.0 0.9999995698091106 99.60742979685995 GOTERM_BP_DIRECT GO:0015031~protein transport 8 0.8743169398907104 0.4691812576369362 O75382, Q9UGM3, F1Q506, Q5F3X8, Q9D8L5, Q9R1R2, O70277, A1A4L0 158 58 1414 1.2343954604975993 1.0 0.9999999503642227 99.99522297415797 UP_KEYWORDS Transport 21 2.2950819672131146 0.5504967452852454 O75382, O88427, Q9UGM3, Q8CI95, U3JAG9, F1Q506, Q1HPL8, Q96FV9, Q3T106, O70277, Q99N01, Q9NRA2, A1A4L0, O95487, O75694, O15431, Q5F3X8, P53992, Q9D8L5, P50365, Q9R1R2 172 190 1616 1.0384332925336597 1.0 0.9553064732519931 99.99577035060948 Annotation Cluster 2 Enrichment Score: 1.5192211077716273 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_KEYWORDS Protein phosphatase 7 0.7650273224043715 0.0041691469144775496 Q15262, P10586, P62714, P28828, Q9VXF1, P28827, P63329 172 16 1616 4.11046511627907 0.5771084771697184 0.349698898332256 5.125816595446753 GOTERM_BP_DIRECT GO:0006470~protein dephosphorylation 7 0.7650273224043715 0.010145372448121352 Q15262, P62714, P28828, Q9VXF1, P28827, Q15750, P63329 158 18 1414 3.4803094233473977 0.9999416184850287 0.9999416184850287 14.801680125454464 INTERPRO IPR004843:Metallophosphoesterase domain 4 0.4371584699453552 0.018398756759464938 P62714, Q9UUH0, Q9VXF1, P63329 166 6 1556 6.248995983935743 0.9992572909573687 0.4805676739333029 22.730338541801487 GOTERM_MF_DIRECT GO:0004722~protein serine/threonine phosphatase activity 4 0.4371584699453552 0.049666207692835626 P62714, Q9VXF1, Q15750, P63329 152 8 1357 4.463815789473684 0.999999802084313 0.92366095844753 49.427984923647415 INTERPRO IPR006186:Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 3 0.32786885245901637 0.05808508895740513 P62714, Q9VXF1, P63329 166 4 1556 7.030120481927711 0.9999999999174858 0.7448152992475772 56.43674489252475 SMART SM00156:PP2Ac 3 0.32786885245901637 0.09043327023272955 P62714, Q9VXF1, P63329 114 4 836 5.5 0.9999921388475056 0.7698898488845806 66.53085016308312 GOTERM_MF_DIRECT GO:0004721~phosphoprotein phosphatase activity 4 0.4371584699453552 0.11426012062302836 P62714, P28828, Q9VXF1, P63329 152 11 1357 3.2464114832535884 0.9999999999999999 0.9746850064648002 80.28561456084994 Annotation Cluster 3 Enrichment Score: 1.1187548845127742 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013783:Immunoglobulin-like fold 17 1.8579234972677594 1.846957510516317E-5 O75382, Q15262, P20241, D2GXS7, A8DYP0, Q04446, O70277, D3YXG0, A4IF63, P22105, P10586, Q23551, P28828, Q9U489, P28827, O18023, Q9R1R2 166 49 1556 3.2520285222522745 0.00714064489712396 0.00714064489712396 0.02564420915780463 INTERPRO IPR003599:Immunoglobulin subtype 9 0.9836065573770493 0.0016415667543096641 Q15262, P10586, Q23551, P20241, P28828, A8DYP0, O18023, P28827, D3YXG0 166 23 1556 3.6678889470927185 0.4713619270160947 0.11969800184931756 2.255562084532814 INTERPRO IPR003961:Fibronectin, type III 10 1.092896174863388 0.0034988415467413405 P22105, Q15262, P10586, Q5VV43, Q23551, P20241, P28828, A8DYP0, O18023, P28827 166 31 1556 3.0237077341624565 0.7433215132156703 0.17656927648277554 4.750544080304175 UP_SEQ_FEATURE domain:Fibronectin type-III 4 7 0.7650273224043715 0.0037157667031272896 P22105, Q15262, P10586, P20241, P28828, O18023, P28827 151 16 1448 4.195364238410597 0.9465898734607717 0.7688936899623287 5.542518050549738 UP_KEYWORDS Protein phosphatase 7 0.7650273224043715 0.0041691469144775496 Q15262, P10586, P62714, P28828, Q9VXF1, P28827, P63329 172 16 1616 4.11046511627907 0.5771084771697184 0.349698898332256 5.125816595446753 SMART SM00409:IG 9 0.9836065573770493 0.0073609189381126155 Q15262, P10586, Q23551, P20241, P28828, A8DYP0, O18023, P28827, D3YXG0 114 23 836 2.869565217391304 0.5999356537054492 0.2631541934276218 8.177621315445183 INTERPRO IPR007110:Immunoglobulin-like domain 9 0.9836065573770493 0.00822658320250798 Q15262, P10586, Q23551, P20241, P28828, A8DYP0, O18023, P28827, D3YXG0 166 29 1556 2.9090153718321563 0.959445803329209 0.33010848743700694 10.83741060565968 GOTERM_BP_DIRECT GO:0006470~protein dephosphorylation 7 0.7650273224043715 0.010145372448121352 Q15262, P62714, P28828, Q9VXF1, P28827, Q15750, P63329 158 18 1414 3.4803094233473977 0.9999416184850287 0.9999416184850287 14.801680125454464 SMART SM00060:FN3 10 1.092896174863388 0.01038236217124289 P22105, Q15262, P10586, Q5VV43, Q23551, P20241, P28828, A8DYP0, O18023, P28827 114 29 836 2.528735632183908 0.7258672289882864 0.2764138608554164 11.353745134188276 INTERPRO IPR013098:Immunoglobulin I-set 6 0.6557377049180327 0.011404557480740906 Q15262, P10586, Q23551, P20241, A8DYP0, D3YXG0 166 14 1556 4.017211703958692 0.988326035861974 0.3901170618521057 14.723919258204464 GOTERM_MF_DIRECT GO:0005001~transmembrane receptor protein tyrosine phosphatase activity 4 0.4371584699453552 0.011412719876432656 Q15262, P10586, P28828, P28827 152 5 1357 7.1421052631578945 0.9691290126979555 0.8242985848035239 14.240051482260851 UP_SEQ_FEATURE domain:Fibronectin type-III 3 7 0.7650273224043715 0.012659002856440005 P22105, Q15262, P10586, P20241, P28828, O18023, P28827 151 20 1448 3.356291390728477 0.9999557754741053 0.9184515339128814 17.727691425226745 INTERPRO IPR013151:Immunoglobulin 4 0.4371584699453552 0.018398756759464938 P20241, P28828, O18023, P28827 166 6 1556 6.248995983935743 0.9992572909573687 0.4805676739333029 22.730338541801487 UP_SEQ_FEATURE domain:Fibronectin type-III 2 7 0.7650273224043715 0.025382728362028057 P22105, Q15262, P10586, P20241, P28828, O18023, P28827 151 23 1448 2.918514252807371 0.9999999983690546 0.920282269471332 32.5515413388474 UP_SEQ_FEATURE domain:Fibronectin type-III 1 7 0.7650273224043715 0.025382728362028057 P22105, Q15262, P10586, P20241, P28828, O18023, P28827 151 23 1448 2.918514252807371 0.9999999983690546 0.920282269471332 32.5515413388474 INTERPRO IPR003598:Immunoglobulin subtype 2 6 0.6557377049180327 0.027102299186119966 P10586, Q23551, P20241, A8DYP0, O18023, D3YXG0 166 17 1556 3.308291991495393 0.999976554219387 0.5330285432381968 31.7192664651327 UP_SEQ_FEATURE domain:Tyrosine-protein phosphatase 2 4 0.4371584699453552 0.027887844047976354 Q15262, P10586, P28828, P28827 151 7 1448 5.4796594134342484 0.9999999997848278 0.9156927083354209 35.15869117327317 UP_SEQ_FEATURE domain:Tyrosine-protein phosphatase 1 4 0.4371584699453552 0.027887844047976354 Q15262, P10586, P28828, P28827 151 7 1448 5.4796594134342484 0.9999999997848278 0.9156927083354209 35.15869117327317 INTERPRO IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type 4 0.4371584699453552 0.04390909272687994 Q15262, P10586, P28828, P28827 166 8 1556 4.686746987951808 0.999999972855308 0.686975021355663 46.39474019265618 UP_KEYWORDS Cell adhesion 8 0.8743169398907104 0.044922846385835796 Q6V0I7, P22105, P10586, P20241, P28828, P28827, Q2PZL6, Q00174 172 32 1616 2.3488372093023253 0.9999227458130626 0.6507773147914875 43.94787585496444 UP_KEYWORDS Immunoglobulin domain 7 0.7650273224043715 0.05767229653135814 Q15262, P10586, Q23551, P20241, P28828, O18023, P28827 172 27 1616 2.4358311800172268 0.9999951515426638 0.6712444807858635 52.675760056419094 SMART SM00408:IGc2 6 0.6557377049180327 0.06676378942299711 P10586, Q23551, P20241, A8DYP0, O18023, D3YXG0 114 17 836 2.588235294117647 0.9998099113827024 0.7602127877684132 54.97231392243553 UP_SEQ_FEATURE domain:Fibronectin type-III 5 4 0.4371584699453552 0.07584350753007954 P22105, P10586, P20241, O18023 151 10 1448 3.835761589403974 1.0 0.9881311453113852 70.12387148042032 UP_SEQ_FEATURE domain:Ig-like C2-type 4 0.4371584699453552 0.07584350753007954 Q15262, P28828, O18023, P28827 151 10 1448 3.835761589403974 1.0 0.9881311453113852 70.12387148042032 UP_SEQ_FEATURE active site:Phosphocysteine intermediate 4 0.4371584699453552 0.07584350753007954 Q15262, P10586, P28828, P28827 151 10 1448 3.835761589403974 1.0 0.9881311453113852 70.12387148042032 INTERPRO IPR003595:Protein-tyrosine phosphatase, catalytic 4 0.4371584699453552 0.0803494340048754 Q15262, P10586, P28828, P28827 166 10 1556 3.749397590361446 0.9999999999999923 0.8030830303191138 68.74937303200392 SMART SM00194:PTPc 4 0.4371584699453552 0.08080287449294582 Q15262, P10586, P28828, P28827 114 8 836 3.6666666666666665 0.9999709815949664 0.7751926504041051 62.202444013165604 INTERPRO IPR000387:Protein-tyrosine/Dual specificity phosphatase 4 0.4371584699453552 0.10217006278059168 Q15262, P10586, P28828, P28827 166 11 1556 3.408543263964951 1.0 0.8122533662182807 77.61058928108837 UP_SEQ_FEATURE domain:MAM 3 0.32786885245901637 0.12106736720128489 Q15262, P28828, P28827 151 6 1448 4.794701986754967 1.0 0.9964550197937214 86.14622608469561 INTERPRO IPR016130:Protein-tyrosine phosphatase, active site 4 0.4371584699453552 0.12604329007730591 Q15262, P10586, P28828, P28827 166 12 1556 3.1244979919678717 1.0 0.845397156372224 84.6001643142231 SMART SM00404:PTPc_motif 4 0.4371584699453552 0.14171893056542875 Q15262, P10586, P28828, P28827 114 10 836 2.933333333333333 0.9999999941107204 0.8782237870904201 82.87655617088978 UP_SEQ_FEATURE disulfide bond 16 1.7486338797814207 0.15578208520742093 Q6V0I7, Q9UGM3, Q15262, Q8K2W3, P20241, Q91W90, Q00174, P22105, P10586, P28828, O75581, P28827, O18023, Q2PZL6, P10079, O88281 151 110 1448 1.3948223961468995 1.0 0.9976607363512282 92.52682766675875 GOTERM_BP_DIRECT GO:0035335~peptidyl-tyrosine dephosphorylation 3 0.32786885245901637 0.1773721674985501 Q15262, P10586, P28827 158 7 1414 3.8354430379746836 1.0 0.9999686412810738 95.34496342277275 INTERPRO IPR000998:MAM domain 3 0.32786885245901637 0.20479206093732702 Q15262, P28828, P28827 166 8 1556 3.5150602409638556 1.0 0.9036491295686981 95.8499525488708 GOTERM_MF_DIRECT GO:0004725~protein tyrosine phosphatase activity 4 0.4371584699453552 0.22832811784136534 Q15262, P10586, P28828, P28827 152 15 1357 2.380701754385965 1.0 0.9901450826075038 96.88485586325328 UP_SEQ_FEATURE signal peptide 18 1.9672131147540985 0.2731913351634892 Q6V0I7, Q9UGM3, Q15262, P20241, Q9UUH0, Q91W90, Q00174, P22105, P10586, Q5VV43, P28828, O75581, O18023, P28827, Q2PZL6, P10079, O88281, Q6NUS6 151 140 1448 1.2329233680227056 1.0 0.9996967096643129 99.245998088503 SMART SM00137:MAM 3 0.32786885245901637 0.2956800616123393 Q15262, P28828, P28827 114 8 836 2.75 1.0 0.9448475014567207 98.25364223221989 UP_KEYWORDS Signal 24 2.622950819672131 0.3147549698164234 Q6V0I7, O75382, O88427, Q9UGM3, Q15262, P20241, Q9UUH0, Q91W90, Q8K4Q0, Q4R9E0, Q00174, D3YXG0, P22105, P10586, Q5VV43, P28828, P27641, O75581, O18023, P28827, P10079, Q2PZL6, O88281, Q6NUS6 172 195 1616 1.156350626118068 1.0 0.8572400601052285 99.14386451801283 UP_KEYWORDS Disulfide bond 20 2.185792349726776 0.31656645317578863 Q6V0I7, Q9UGM3, Q15262, Q8K2W3, P20241, Q91W90, Q99N01, Q00174, D3YXG0, P22105, P10586, Q23551, P28828, O75694, O75581, P28827, O18023, Q2PZL6, P10079, O88281 172 159 1616 1.18180488518356 1.0 0.8453945947646467 99.17193637771038 GOTERM_BP_DIRECT GO:0031175~neuron projection development 3 0.32786885245901637 0.34972359310339074 Q15262, P28828, P28827 158 11 1414 2.4407364787111625 1.0 0.999999758851454 99.88413806125376 GOTERM_CC_DIRECT GO:0005911~cell-cell junction 3 0.32786885245901637 0.3670166178076398 Q15262, P28828, P28827 157 12 1477 2.3519108280254777 1.0 0.9978306962163177 99.71337297745993 GOTERM_BP_DIRECT GO:0007155~cell adhesion 5 0.546448087431694 0.4312267512095723 P22105, Q15262, P10586, P28828, Q2PZL6 158 30 1414 1.4915611814345993 1.0 0.9999999204460437 99.98586425259116 UP_SEQ_FEATURE topological domain:Extracellular 13 1.4207650273224044 0.5251652162714968 O88427, Q6V0I7, Q15262, P10586, Q5VV43, P20241, P28828, O15431, O75581, O18023, P28827, Q2PZL6, Q6NUS6 151 114 1448 1.0935285232949925 1.0 0.999997796626272 99.99888928200937 UP_KEYWORDS Glycoprotein 25 2.73224043715847 0.5589210244126934 Q15262, Q9UGM3, D3YXG0, P22105, P10586, Q5VV43, P28828, O75694, O15431, P28827, O18023, P10079, O88427, A7XDQ9, Q6V0I7, P20241, Q99N01, Q4R9E0, Q00174, Q9NRA2, Q3UR85, O75581, Q6N021, Q2PZL6, Q6NUS6 172 229 1616 1.0256931044988322 1.0 0.9533821570531652 99.99666711033808 UP_KEYWORDS Receptor 8 0.8743169398907104 0.5758477084095406 Q8NI08, Q86DA5, Q15262, P10586, P35570, P28828, O75581, P28827 172 67 1616 1.121832696980215 1.0 0.9573604707892643 99.99796398355991 GOTERM_BP_DIRECT GO:0007165~signal transduction 6 0.6557377049180327 0.631766099702644 Q86DA5, Q15262, Q3B7D5, P28828, P28827, Q96FV9 158 48 1414 1.1186708860759493 1.0 0.9999999993939053 99.99998471723475 UP_KEYWORDS Membrane 49 5.355191256830602 0.7482557906535333 Q7KRY7, Q15262, Q9UPN3, Q8K2W3, F1Q506, Q7L014, Q0VCR6, Q1HPL8, Q8K4K5, P09324, P63329, Q5ZM73, A8DZE7, P10586, Q5VV43, P28828, O75694, O15431, P53992, P28827, O18023, P50365, Q6VNB8, Q6DC04, Q8IV36, A7XDQ9, O88427, Q6V0I7, Q12829, Q8CI95, Q9D850, Q9BTW9, P20241, Q9UUH0, Q8BGQ6, Q4R9E0, Q99N01, Q9NRA2, A1A4L0, O95487, Q3UR85, G5EBQ8, Q5F3X8, Q80TE7, O75581, Q9D8L5, Q2PZL6, Q6NUS6, Q06486 172 485 1616 0.9492208103572285 1.0 0.9846799694834646 99.9999971469043 UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 19 2.0765027322404372 0.764174445723854 Q6V0I7, A7XDQ9, O88427, Q9UGM3, Q15262, P20241, Q99N01, Q00174, P22105, P10586, Q5VV43, P28828, O15431, O75581, P28827, O18023, Q2PZL6, P10079, Q6NUS6 151 197 1448 0.9248663730796384 1.0 0.9999999997919269 99.99999997545416 UP_SEQ_FEATURE transmembrane region 26 2.841530054644809 0.8373467137524857 Q15262, Q8K2W3, Q0VCR6, Q5ZM73, A8DZE7, P10586, Q5VV43, P28828, O15431, O18023, P28827, P50365, Q6V0I7, A7XDQ9, O88427, Q8IV36, Q9D850, P20241, Q9UUH0, Q99N01, Q9NRA2, Q3UR85, O75581, Q96AY4, Q2PZL6, Q6NUS6 151 280 1448 0.8904446546830652 1.0 0.9999999999980591 99.99999999991704 GOTERM_CC_DIRECT GO:0005887~integral component of plasma membrane 6 0.6557377049180327 0.86371005297142 Q15262, P10586, O15431, P28827, Q99N01, Q9NRA2 157 68 1477 0.8300861745972274 1.0 0.9999953609856227 99.99999999917026 UP_SEQ_FEATURE topological domain:Cytoplasmic 14 1.530054644808743 0.8819186107012542 Q6V0I7, O88427, Q15262, P20241, Q5ZM73, P10586, Q5VV43, P28828, O75581, O15431, O18023, P28827, Q2PZL6, Q6NUS6 151 162 1448 0.828713923636661 1.0 0.999999999999947 99.99999999999939 GOTERM_CC_DIRECT GO:0016021~integral component of membrane 28 3.060109289617486 0.9185275718080618 Q9UPN3, Q15262, Q8K2W3, Q0VCR6, A8DZE7, P10586, Q5VV43, P28828, O15431, O18023, P28827, P50365, Q6DC04, Q6V0I7, A7XDQ9, O88427, Q9D850, P20241, Q9UUH0, Q8BGQ6, Q4R9E0, Q99N01, Q9NRA2, Q3UR85, G5EBQ8, O75581, Q2PZL6, Q6NUS6 157 314 1477 0.8388981297415716 1.0 0.9999993794728859 99.99999999999886 UP_KEYWORDS Transmembrane helix 29 3.169398907103825 0.9548510950028085 Q9UPN3, Q15262, Q8K2W3, Q0VCR6, Q5ZM73, A8DZE7, P10586, Q5VV43, P28828, O15431, O18023, P28827, P50365, Q6DC04, Q6V0I7, A7XDQ9, O88427, Q9D850, P20241, Q9UUH0, Q8BGQ6, Q4R9E0, Q99N01, Q9NRA2, Q3UR85, G5EBQ8, O75581, Q2PZL6, Q6NUS6 172 339 1616 0.8037319064279345 1.0 0.9995419302014176 100.0 UP_KEYWORDS Transmembrane 29 3.169398907103825 0.9585679368810474 Q9UPN3, Q15262, Q8K2W3, Q0VCR6, Q5ZM73, A8DZE7, P10586, Q5VV43, P28828, O15431, O18023, P28827, P50365, Q6DC04, Q6V0I7, A7XDQ9, O88427, Q9D850, P20241, Q9UUH0, Q8BGQ6, Q4R9E0, Q99N01, Q9NRA2, Q3UR85, G5EBQ8, O75581, Q2PZL6, Q6NUS6 172 341 1616 0.7990179363022574 1.0 0.9995542673107067 100.0 Annotation Cluster 4 Enrichment Score: 1.001153308735501 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_DIRECT GO:0004842~ubiquitin-protein transferase activity 14 1.530054644808743 0.004538391211019968 Q80Z37, Q86Y13, Q5PQN1, D2GXS7, Q8BH70, O70277, P58283, A4IF63, Q80TP3, Q9U489, A9JTP3, Q9R1R2, Q6TFL4, Q9D787 152 54 1357 2.314571150097466 0.7479839379229943 0.7479839379229943 5.9060919551077955 GOTERM_MF_DIRECT GO:0061630~ubiquitin protein ligase activity 7 0.7650273224043715 0.017692849885900273 O75382, Q80Z37, Q86Y13, Q9R1R2, O70277, P58283, Q9D787 152 20 1357 3.124671052631579 0.9955235525677568 0.8351921743679032 21.251300774071325 UP_KEYWORDS Ubl conjugation pathway 16 1.7486338797814207 0.04973852741561172 Q12829, P0C8Z3, Q80Z37, Q86Y13, Q5PQN1, D2GXS7, Q38997, Q5MNV8, Q8BH70, P58283, A4IF63, Q80TP3, Q9FHQ6, A9JTP3, Q4V8C4, Q9D787 172 91 1616 1.6519294658829542 0.9999727301313943 0.650402511076284 47.40521533916407 GOTERM_MF_DIRECT GO:0016874~ligase activity 8 0.8743169398907104 0.09591768441925697 Q80Z37, Q80TP3, Q86Y13, D2GXS7, A9JTP3, P58283, A4IF63, Q9D787 152 36 1357 1.9839181286549707 0.9999999999999462 0.9872816466839477 74.06308354484861 INTERPRO IPR013083:Zinc finger, RING/FYVE/PHD-type 11 1.2021857923497268 0.10339317492109655 O75382, P0C8Z3, Q80Z37, Q86Y13, Q8WYB5, D2GXS7, Q6VNB8, Q9R1R2, O70277, A4IF63, Q9D787 166 61 1556 1.6903021923760617 1.0 0.8038101190951077 78.0304360386885 INTERPRO IPR001841:Zinc finger, RING-type 8 0.8743169398907104 0.1355332181905657 O75382, Q80Z37, Q86Y13, D2GXS7, A9JTP3, Q9R1R2, O70277, A4IF63 166 41 1556 1.8289744343226566 1.0 0.8575258729243258 86.76655183521405 SMART SM00184:RING 8 0.8743169398907104 0.16298747921868717 O75382, Q80Z37, Q86Y13, D2GXS7, A9JTP3, Q9R1R2, O70277, A4IF63 114 34 836 1.7254901960784315 0.9999999997377217 0.8898774556405381 87.18401507015534 UP_KEYWORDS Ligase 8 0.8743169398907104 0.19119756898790405 Q80Z37, Q86Y13, Q4R550, D2GXS7, Q5F408, P58283, A4IF63, Q9D787 172 45 1616 1.6702842377260982 1.0 0.8381990707562137 93.09265327754738 GOTERM_MF_DIRECT GO:0008270~zinc ion binding 18 1.9672131147540985 0.33804998890199367 O75382, P0C8Z3, Q80Z37, Q83F39, Q86Y13, D2GXS7, E1C2V1, Q3T106, O70277, A4IF63, O95487, Q80TP3, Q8WYB5, Q9U489, P53992, Q6N021, A9JTP3, Q9R1R2 152 136 1357 1.181598297213622 1.0 0.9974012559361222 99.60000876383882 UP_KEYWORDS Zinc-finger 21 2.2950819672131146 0.4110121903335951 O75382, P0C8Z3, Q80Z37, Q14590, Q86Y13, D2GXS7, E1C2V1, Q3T106, O70277, P58283, A4IF63, Q80TP3, Q8WYB5, Q6NYU2, Q9U489, P10076, A9CPT4, A9JTP3, Q9R1R2, Q6VNB8, O70230 172 177 1616 1.114702404414663 1.0 0.9065722118890928 99.87277343684148 GOTERM_BP_DIRECT GO:0000209~protein polyubiquitination 4 0.4371584699453552 0.41784230880088424 Q80Z37, Q80TP3, Q86Y13, Q9D787 158 21 1414 1.7046413502109705 1.0 0.999999904371112 99.97962940411654 Annotation Cluster 5 Enrichment Score: 0.9029807314068523 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013320:Concanavalin A-like lectin/glucanase, subgroup 8 0.8743169398907104 0.01879998766495246 Q6V0I7, A7XDQ9, Q15262, P28828, P28827, Q6VNB8, Q2PZL6, Q00174 166 27 1556 2.777331548415886 0.9993662361582352 0.45863028780396875 23.16776892943986 UP_KEYWORDS Cell adhesion 8 0.8743169398907104 0.044922846385835796 Q6V0I7, P22105, P10586, P20241, P28828, P28827, Q2PZL6, Q00174 172 32 1616 2.3488372093023253 0.9999227458130626 0.6507773147914875 43.94787585496444 INTERPRO IPR000742:Epidermal growth factor-like domain 8 0.8743169398907104 0.07846672855665351 Q6V0I7, P22105, O75581, P10079, Q2PZL6, O88281, Q00174, D3YXG0 166 36 1556 2.0829986613119145 0.999999999999983 0.8115146208895151 67.84917201013876 UP_KEYWORDS Extracellular matrix 4 0.4371584699453552 0.07995924933838075 P22105, P10079, Q00174, D3YXG0 172 10 1616 3.7581395348837208 0.9999999649849209 0.7330185039229804 64.99226946421753 INTERPRO IPR013032:EGF-like, conserved site 7 0.7650273224043715 0.10173316004799934 Q6V0I7, P22105, P10079, Q2PZL6, O88281, Q00174, D3YXG0 166 31 1556 2.1165954139137195 1.0 0.8363301017861416 77.45882149984857 GOTERM_BP_DIRECT GO:0007156~homophilic cell adhesion via plasma membrane adhesion molecules 4 0.4371584699453552 0.1397878907457664 Q6V0I7, P28828, P28827, Q2PZL6 158 12 1414 2.9831223628691985 1.0 0.9998762110945267 90.60897193339802 UP_KEYWORDS EGF-like domain 7 0.7650273224043715 0.1422035008774936 Q6V0I7, P22105, O75581, P10079, Q2PZL6, O88281, D3YXG0 172 34 1616 1.9343365253077975 0.999999999999981 0.8104406385188803 85.51226062155149 UP_SEQ_FEATURE domain:Laminin G-like 2 3 0.32786885245901637 0.1583391764628574 Q6V0I7, Q2PZL6, Q00174 151 7 1448 4.109744560075686 1.0 0.9964915026388598 92.8661231925424 UP_SEQ_FEATURE domain:Laminin G-like 1 3 0.32786885245901637 0.1583391764628574 Q6V0I7, Q2PZL6, Q00174 151 7 1448 4.109744560075686 1.0 0.9964915026388598 92.8661231925424 SMART SM00181:EGF 8 0.8743169398907104 0.1820436553695256 Q6V0I7, P22105, O75581, P10079, Q2PZL6, O88281, Q00174, D3YXG0 114 35 836 1.676190476190476 0.9999999999849153 0.896192076221417 90.17672098636395 INTERPRO IPR001791:Laminin G domain 3 0.32786885245901637 0.20479206093732702 Q6V0I7, Q2PZL6, Q00174 166 8 1556 3.5150602409638556 1.0 0.9036491295686981 95.8499525488708 SMART SM00282:LamG 3 0.32786885245901637 0.2419607648321944 Q6V0I7, Q2PZL6, Q00174 114 7 836 3.1428571428571423 0.9999999999999988 0.942876596455174 95.91918305847122 UP_KEYWORDS Secreted 6 0.6557377049180327 0.7530410573379386 Q9UGM3, P22105, P10079, O88281, Q00174, D3YXG0 172 58 1616 0.9719326383319968 1.0 0.9846298958277374 99.99999775950693 Annotation Cluster 6 Enrichment Score: 0.8902579466991069 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:EGF-like 4 5 0.546448087431694 0.014120659425564704 Q6V0I7, P22105, O75581, Q2PZL6, O88281 151 10 1448 4.794701986754967 0.9999862182685328 0.8933745795486432 19.573594386296943 UP_SEQ_FEATURE domain:EGF-like 6 4 0.4371584699453552 0.04128603780056709 Q6V0I7, P22105, Q2PZL6, O88281 151 8 1448 4.794701986754967 0.9999999999999961 0.9370338687771612 47.57585895507701 INTERPRO IPR000152:EGF-type aspartate/asparagine hydroxylation site 5 0.546448087431694 0.06553324590163546 Q6V0I7, P10079, Q2PZL6, O88281, D3YXG0 166 15 1556 3.1244979919678717 0.9999999999962088 0.7680002379964709 60.983961528869145 INTERPRO IPR000742:Epidermal growth factor-like domain 8 0.8743169398907104 0.07846672855665351 Q6V0I7, P22105, O75581, P10079, Q2PZL6, O88281, Q00174, D3YXG0 166 36 1556 2.0829986613119145 0.999999999999983 0.8115146208895151 67.84917201013876 INTERPRO IPR018097:EGF-like calcium-binding, conserved site 5 0.546448087431694 0.08041847174226152 Q6V0I7, P10079, Q2PZL6, O88281, D3YXG0 166 16 1556 2.9292168674698797 0.9999999999999926 0.7875355272776485 68.78193393798698 INTERPRO IPR009030:Insulin-like growth factor binding protein, N-terminal 5 0.546448087431694 0.08041847174226152 Q6V0I7, P10079, Q2PZL6, O88281, D3YXG0 166 16 1556 2.9292168674698797 0.9999999999999926 0.7875355272776485 68.78193393798698 UP_SEQ_FEATURE domain:EGF-like 2; calcium-binding 4 0.4371584699453552 0.09662346152074484 Q6V0I7, P10079, Q2PZL6, O88281 151 11 1448 3.487055990367249 1.0 0.99094297898818 78.91164094444262 INTERPRO IPR013032:EGF-like, conserved site 7 0.7650273224043715 0.10173316004799934 Q6V0I7, P22105, P10079, Q2PZL6, O88281, Q00174, D3YXG0 166 31 1556 2.1165954139137195 1.0 0.8363301017861416 77.45882149984857 GOTERM_MF_DIRECT GO:0005509~calcium ion binding 11 1.2021857923497268 0.12049692841021763 Q6V0I7, Q8IV35, Q9UPN3, P20241, Q8BGQ6, P70531, P10079, Q2PZL6, O88281, D3YXG0, Q5ZM73 152 60 1357 1.636732456140351 1.0 0.970893314775189 82.06455846413128 UP_SEQ_FEATURE domain:EGF-like 3; calcium-binding 3 0.32786885245901637 0.12106736720128489 Q6V0I7, P10079, Q2PZL6 151 6 1448 4.794701986754967 1.0 0.9964550197937214 86.14622608469561 UP_KEYWORDS EGF-like domain 7 0.7650273224043715 0.1422035008774936 Q6V0I7, P22105, O75581, P10079, Q2PZL6, O88281, D3YXG0 172 34 1616 1.9343365253077975 0.999999999999981 0.8104406385188803 85.51226062155149 INTERPRO IPR001881:EGF-like calcium-binding 5 0.546448087431694 0.1541954412005772 Q6V0I7, P10079, Q2PZL6, O88281, D3YXG0 166 20 1556 2.3433734939759034 1.0 0.8770574530213363 90.22638079499899 UP_SEQ_FEATURE domain:EGF-like 5 3 0.32786885245901637 0.1583391764628574 Q6V0I7, P22105, Q2PZL6 151 7 1448 4.109744560075686 1.0 0.9964915026388598 92.8661231925424 SMART SM00181:EGF 8 0.8743169398907104 0.1820436553695256 Q6V0I7, P22105, O75581, P10079, Q2PZL6, O88281, Q00174, D3YXG0 114 35 836 1.676190476190476 0.9999999999849153 0.896192076221417 90.17672098636395 GOTERM_BP_DIRECT GO:0021987~cerebral cortex development 3 0.32786885245901637 0.22002655698450152 Q6V0I7, O75581, Q2PZL6 158 8 1414 3.356012658227848 1.0 0.9999962854112976 97.98315375554718 SMART SM00179:EGF_CA 5 0.546448087431694 0.28004411578524024 Q6V0I7, P10079, Q2PZL6, O88281, D3YXG0 114 20 836 1.8333333333333333 1.0 0.9564570671626769 97.74965828340626 UP_SEQ_FEATURE domain:EGF-like 1 4 0.4371584699453552 0.34352014562911853 Q6V0I7, O75581, P10079, Q2PZL6 151 20 1448 1.917880794701987 1.0 0.9999223587182007 99.84137145789099 UP_SEQ_FEATURE domain:EGF-like 3 3 0.32786885245901637 0.43432576905723674 P22105, O75581, O88281 151 14 1448 2.054872280037843 1.0 0.9999821974678472 99.9837796223686 UP_KEYWORDS Secreted 6 0.6557377049180327 0.7530410573379386 Q9UGM3, P22105, P10079, O88281, Q00174, D3YXG0 172 58 1616 0.9719326383319968 1.0 0.9846298958277374 99.99999775950693 Annotation Cluster 7 Enrichment Score: 0.7578306752147822 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_KEYWORDS Tight junction 3 0.32786885245901637 0.1255976299135066 Q7KRY7, Q9BTW9, P20241 172 6 1616 4.6976744186046515 0.999999999999017 0.7847622170799421 81.55508388096827 GOTERM_CC_DIRECT GO:0005923~bicellular tight junction 3 0.32786885245901637 0.16348232265991156 Q7KRY7, Q9BTW9, P20241 157 7 1477 4.031847133757961 1.0 0.9988674570749488 89.82616527144692 GOTERM_CC_DIRECT GO:0016328~lateral plasma membrane 3 0.32786885245901637 0.20349854011666524 Q7KRY7, Q9BTW9, P20241 157 8 1477 3.5278662420382165 1.0 0.994414604432185 94.56828203730426 UP_KEYWORDS Cell junction 8 0.8743169398907104 0.22267105036619325 Q7KRY7, Q15262, Q9BTW9, P20241, Q80TE7, Q00174, Q9NRA2, D3YXG0 172 47 1616 1.599208312716477 1.0 0.8329228128951974 95.81003615432827 Annotation Cluster 8 Enrichment Score: 0.7561802431082444 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_DIRECT GO:0042162~telomeric DNA binding 3 0.32786885245901637 0.03422039310359347 P27641, Q8BKX6, Q96Q15 152 3 1357 8.927631578947368 0.9999738155586766 0.8787704027276376 37.2493535228265 GOTERM_BP_DIRECT GO:0006974~cellular response to DNA damage stimulus 8 0.8743169398907104 0.08416932052769206 Q96EB6, Q80Z37, Q80TP3, Q4QY64, Q86WJ1, P27641, Q8BKX6, O75943 158 35 1414 2.0455696202531644 1.0 0.9995198325754163 74.87236647679086 GOTERM_BP_DIRECT GO:0006281~DNA repair 7 0.7650273224043715 0.1673463511151581 Q96EB6, Q80TP3, Q86WJ1, P27641, Q8BKX6, Q96Q15, O75943 158 34 1414 1.8425167535368576 1.0 0.9999663262444561 94.3692215960412 GOTERM_BP_DIRECT GO:0000723~telomere maintenance 3 0.32786885245901637 0.26340037632717395 P27641, Q8BKX6, Q96Q15 158 9 1414 2.983122362869198 1.0 0.9999982993894775 99.17902789456677 UP_KEYWORDS DNA damage 8 0.8743169398907104 0.32590239437437934 Q80Z37, Q80TP3, Q4QY64, Q86WJ1, P27641, Q8BKX6, Q96Q15, O75943 172 53 1616 1.418165862220272 1.0 0.848831034097882 99.30364663167818 UP_KEYWORDS DNA repair 5 0.546448087431694 0.7017130225631162 Q80TP3, Q86WJ1, P27641, Q8BKX6, Q96Q15 172 44 1616 1.0676532769556026 1.0 0.9783730718402613 99.99997583304061 Annotation Cluster 9 Enrichment Score: 0.6746096608902884 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_KEYWORDS Helicase 6 0.6557377049180327 0.10112702144198019 Q6NYU2, Q86WJ1, P27641, Q7L014, Q8IY37, Q3TKT4 172 24 1616 2.3488372093023258 0.9999999997103624 0.7687276759533234 73.88750901510585 UP_SEQ_FEATURE domain:Helicase C-terminal 4 0.4371584699453552 0.1439819021606889 Q86WJ1, Q7L014, Q8IY37, Q3TKT4 151 13 1448 2.9505858380030565 1.0 0.9970507061471412 90.7563881930947 UP_SEQ_FEATURE domain:Helicase ATP-binding 4 0.4371584699453552 0.17003276139102225 Q86WJ1, Q7L014, Q8IY37, Q3TKT4 151 14 1448 2.7398297067171242 1.0 0.9971683556978361 94.2421936542177 INTERPRO IPR001650:Helicase, C-terminal 4 0.4371584699453552 0.23636701065270624 Q86WJ1, Q7L014, Q8IY37, Q3TKT4 166 16 1556 2.343373493975904 1.0 0.9122517376876633 97.63565549330895 INTERPRO IPR014001:Helicase, superfamily 1/2, ATP-binding domain 4 0.4371584699453552 0.23636701065270624 Q86WJ1, Q7L014, Q8IY37, Q3TKT4 166 16 1556 2.343373493975904 1.0 0.9122517376876633 97.63565549330895 SMART SM00487:DEXDc 4 0.4371584699453552 0.370190661435571 Q86WJ1, Q7L014, Q8IY37, Q3TKT4 114 16 836 1.8333333333333333 1.0 0.9722111552040765 99.51984731898733 SMART SM00490:HELICc 4 0.4371584699453552 0.370190661435571 Q86WJ1, Q7L014, Q8IY37, Q3TKT4 114 16 836 1.8333333333333333 1.0 0.9722111552040765 99.51984731898733 Annotation Cluster 10 Enrichment Score: 0.63870363518379 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_KEYWORDS Serine/threonine-protein kinase 10 1.092896174863388 0.059421297257478654 Q23551, Q5ZJB4, Q05609, Q5R754, Q8BKX6, Q38997, P70531, Q96Q15, Q06486, Q86SG6 172 48 1616 1.9573643410852715 0.9999966932677702 0.6506318965102409 53.77019258400142 INTERPRO IPR011009:Protein kinase-like domain 12 1.3114754098360655 0.08191690801889881 Q23551, Q5ZJB4, Q05609, Q5R754, A8DYP0, Q8BKX6, Q38997, P70531, Q96Q15, P09324, Q06486, Q86SG6 166 66 1556 1.704271631982475 0.999999999999996 0.7785002377914952 69.48094495723784 GOTERM_BP_DIRECT GO:0018105~peptidyl-serine phosphorylation 5 0.546448087431694 0.09199811036827553 Q23551, Q6QI06, Q8BKX6, Q96Q15, Q06486 158 16 1414 2.7966772151898733 1.0 0.9995419517073006 78.04258132512088 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 18 1.9672131147540985 0.0925232264352967 Q6DDU8, Q86WJ1, Q5R754, Q7L014, Q8IY37, Q38997, P70531, Q3TKT4, P09324, Q9QXL2, Q5ZJB4, Q4QY64, Q6NYU2, Q05609, Q9NU22, O75943, Q86SG6, Q06486 151 118 1448 1.4627904366371085 1.0 0.9938656268125067 77.39695825503172 GOTERM_MF_DIRECT GO:0004672~protein kinase activity 9 0.9836065573770493 0.10653112102282124 Q3B7D5, Q23551, Q05609, Q5R754, A8DYP0, Q38997, Q96Q15, Q06486, Q86SG6 152 44 1357 1.8261064593301435 0.9999999999999984 0.9859675531028242 77.85470273475303 UP_KEYWORDS ATP-binding 24 2.622950819672131 0.12486089301382244 Q6DDU8, Q4R550, Q86WJ1, Q7L014, Q5R754, Q8IY37, Q38997, P70531, Q5F408, Q3TKT4, P09324, Q9QXL2, Q5ZJB4, Q23551, Q4QY64, Q6NYU2, P27641, Q05609, Q9NU22, Q8BKX6, Q96Q15, O75943, Q86SG6, Q06486 172 171 1616 1.3186454508363934 0.9999999999988308 0.8013399057568332 81.35839260402578 GOTERM_MF_DIRECT GO:0005524~ATP binding 26 2.841530054644809 0.13505077447162844 Q86WJ1, Q5R754, Q7L014, Q8IY37, Q38997, P70531, P09324, Q6P5D8, Q9QXL2, Q4QY64, Q6NYU2, Q05609, P27641, Q96Q15, Q86SG6, Q6DDU8, Q4R550, A8DYP0, Q5F408, Q3TKT4, Q5ZJB4, Q23551, Q9NU22, Q8BKX6, O75943, Q06486 152 181 1357 1.2824222157603955 1.0 0.9743543915551799 85.65413570100037 INTERPRO IPR017441:Protein kinase, ATP binding site 8 0.8743169398907104 0.16289302986912063 Q23551, Q5ZJB4, Q05609, Q5R754, Q38997, P09324, Q06486, Q86SG6 166 43 1556 1.743905855982068 1.0 0.8841971849796252 91.5332003381334 INTERPRO IPR008271:Serine/threonine-protein kinase, active site 7 0.7650273224043715 0.19113562180924598 Q23551, Q5ZJB4, Q05609, Q5R754, Q38997, Q06486, Q86SG6 166 37 1556 1.773363725170954 1.0 0.898350587596365 94.74295486481009 UP_KEYWORDS Kinase 12 1.3114754098360655 0.2306555089282969 Q23551, Q5ZJB4, Q05609, Q5R754, Q8BKX6, Q38997, P70531, Q15750, Q96Q15, P09324, Q06486, Q86SG6 172 81 1616 1.3919035314384152 1.0 0.8249126902903047 96.32094647419865 INTERPRO IPR000719:Protein kinase, catalytic domain 9 0.9836065573770493 0.2514725265203528 Q23551, Q5ZJB4, Q05609, Q5R754, A8DYP0, Q38997, P09324, Q06486, Q86SG6 166 57 1556 1.4800253646163601 1.0 0.9177016318478749 98.2084831752886 UP_KEYWORDS Nucleotide-binding 26 2.841530054644809 0.28631905070222174 Q86WJ1, Q5R754, Q7L014, Q8IY37, Q38997, P70531, P09324, Q5ZM73, Q9QXL2, Q4QY64, Q05609, P27641, Q6NYU2, Q96Q15, Q86SG6, Q12829, Q6DDU8, Q4R550, Q5F408, Q3TKT4, Q23551, Q5ZJB4, Q9NU22, Q8BKX6, O75943, Q06486 172 210 1616 1.1632336655592468 1.0 0.8471117178903567 98.57130073876289 GOTERM_MF_DIRECT GO:0004674~protein serine/threonine kinase activity 7 0.7650273224043715 0.34285542692245796 Q23551, Q05609, Q8BKX6, Q38997, Q96Q15, Q06486, Q86SG6 152 43 1357 1.4533353733170133 1.0 0.9969189860940998 99.6371708773958 INTERPRO IPR027417:P-loop containing nucleoside triphosphate hydrolase 15 1.639344262295082 0.3549886552097803 Q6DDU8, Q12829, Q2IA00, Q86WJ1, Q7L014, Q8IY37, Q3TKT4, Q99KF0, Q5ZM73, Q9QXL2, Q4QY64, Q6NYU2, Q9NU22, Q9R095, O75943 166 117 1556 1.2017299969107198 1.0 0.9732133918212762 99.77321720848451 UP_SEQ_FEATURE active site:Proton acceptor 10 1.092896174863388 0.3564338364713503 Q96EB6, A8DZE7, Q5ZJB4, Q5R9W5, Q05609, Q5R754, Q38997, P09324, Q06486, Q86SG6 151 74 1448 1.2958654018256668 1.0 0.9999345914188026 99.88298993226168 UP_SEQ_FEATURE binding site:ATP 8 0.8743169398907104 0.4125236485207239 Q5ZJB4, Q05609, Q5R754, Q38997, Q5F408, P09324, Q06486, Q86SG6 151 59 1448 1.300258165899652 1.0 0.9999782056200959 99.97105142586635 UP_KEYWORDS Transferase 25 2.73224043715847 0.48025889627488383 A7XDQ9, Q8IZ69, O95749, P12276, Q5PQN1, Q5R754, P70531, Q38997, Q04446, Q15750, P09324, P56966, Q80TP3, Q23551, Q5ZJB4, Q8WYB5, Q05609, Q8BKX6, B4NKI9, A9JTP3, Q6VNB8, Q96Q15, Q6DC04, Q86SG6, Q06486 172 221 1616 1.062822266652636 1.0 0.9325405641166595 99.97367017687272 SMART SM00220:S_TKc 7 0.7650273224043715 0.48679863364034237 Q23551, Q5ZJB4, Q05609, Q5R754, Q38997, Q06486, Q86SG6 114 41 836 1.2520325203252032 1.0 0.9922944231092466 99.95485951746485 UP_SEQ_FEATURE domain:Protein kinase 7 0.7650273224043715 0.494284132269196 Q5ZJB4, Q05609, Q5R754, Q38997, P09324, Q06486, Q86SG6 151 54 1448 1.2430708854549914 1.0 0.999994942155998 99.9970843265979 GOTERM_MF_DIRECT GO:0016301~kinase activity 5 0.546448087431694 0.6473956398936076 Q23551, Q05609, Q8BKX6, Q15750, Q06486 152 39 1357 1.1445681511470984 1.0 0.9999302927784017 99.99991265926309 GOTERM_BP_DIRECT GO:0006468~protein phosphorylation 6 0.6557377049180327 0.7502483503856718 Q3B7D5, Q23551, A8DYP0, Q38997, Q06486, Q86SG6 158 55 1414 0.976294591484465 1.0 0.9999999999969775 99.99999996569096 Annotation Cluster 11 Enrichment Score: 0.6151907394439349 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011993:Pleckstrin homology-like domain 6 0.6557377049180327 0.1677853452141698 Q54KA7, Q8CI95, P35570, Q9Y2H5, A8DYP0, Q6VNB8 166 28 1556 2.008605851979346 1.0 0.8846118546839488 92.19504265705264 INTERPRO IPR001849:Pleckstrin homology domain 4 0.4371584699453552 0.17880797686597943 Q54KA7, Q8CI95, P35570, Q9Y2H5 166 14 1556 2.6781411359724614 1.0 0.8873947514841131 93.51424611064203 SMART SM00233:PH 4 0.4371584699453552 0.29092207755185656 Q54KA7, Q8CI95, P35570, Q9Y2H5 114 14 836 2.095238095238095 1.0 0.9524034903754329 98.11245328912183 UP_SEQ_FEATURE domain:PH 3 0.32786885245901637 0.3965696251048856 Q8CI95, P35570, Q9Y2H5 151 13 1448 2.2129393785022926 1.0 0.9999713797660668 99.9563617181365 Annotation Cluster 12 Enrichment Score: 0.587402288117774 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:WD 7 6 0.6557377049180327 0.12326202083507098 Q8IV35, Q9QXL2, Q5F3X8, Q8K4Q0, Q4V8C4, Q8K4K5 151 26 1448 2.2129393785022926 1.0 0.9956986200232395 86.66670840769271 UP_SEQ_FEATURE repeat:WD 5 8 0.8743169398907104 0.13592345960027508 Q8IV35, Q9QXL2, Q5F3X8, Q6VNB8, Q8K4Q0, P55884, Q4V8C4, Q8K4K5 151 42 1448 1.826553137811416 1.0 0.9968133847490568 89.32984699833094 UP_SEQ_FEATURE repeat:WD 4 8 0.8743169398907104 0.17683512530156703 Q8IV35, Q9QXL2, Q5F3X8, Q6VNB8, Q8K4Q0, P55884, Q4V8C4, Q8K4K5 151 45 1448 1.7047829286239882 1.0 0.9972340051644223 94.92410898720216 INTERPRO IPR017986:WD40-repeat-containing domain 10 1.092896174863388 0.2034511981114056 Q8IV35, Q9QXL2, Q5F3X8, Q6VNB8, Q8K4Q0, O42249, P55884, Q4V8C4, Q8K4K5, Q9UPZ3 166 62 1556 1.5118538670812283 1.0 0.90794125514505 95.75171784278848 UP_SEQ_FEATURE repeat:WD 6 6 0.6557377049180327 0.21150489151792246 Q8IV35, Q9QXL2, Q5F3X8, Q8K4Q0, Q4V8C4, Q8K4K5 151 31 1448 1.8560136722922453 1.0 0.9987430591299067 97.37414369376685 INTERPRO IPR015943:WD40/YVTN repeat-like-containing domain 10 1.092896174863388 0.21703352795765526 Q8IV35, Q9QXL2, Q5F3X8, Q6VNB8, Q8K4Q0, O42249, P55884, Q4V8C4, Q8K4K5, Q9UPZ3 166 63 1556 1.4878561866513675 1.0 0.9012703687773649 96.65424556820743 INTERPRO IPR019775:WD40 repeat, conserved site 6 0.6557377049180327 0.22585027484882392 Q8IV35, Q9QXL2, Q6VNB8, O42249, Q4V8C4, Q8K4K5 166 31 1556 1.8142246404974738 1.0 0.906037529101139 97.14110088870014 UP_KEYWORDS WD repeat 9 0.9836065573770493 0.2343721363264754 Q8IV35, Q9QXL2, Q5F3X8, Q6VNB8, Q8K4Q0, O42249, P55884, Q4V8C4, Q8K4K5 172 56 1616 1.5099667774086378 1.0 0.8207892160305894 96.53862901194292 UP_SEQ_FEATURE repeat:WD 3 8 0.8743169398907104 0.27155487485054974 Q8IV35, Q9QXL2, Q5F3X8, Q6VNB8, Q8K4Q0, P55884, Q4V8C4, Q8K4K5 151 51 1448 1.504220231138813 1.0 0.9997544101183179 99.21957127627591 UP_SEQ_FEATURE repeat:WD 2 8 0.8743169398907104 0.3058667473781962 Q8IV35, Q9QXL2, Q5F3X8, Q6VNB8, Q8K4Q0, P55884, Q4V8C4, Q8K4K5 151 53 1448 1.4474572035486695 1.0 0.9998345555481242 99.62728138398572 UP_SEQ_FEATURE repeat:WD 1 8 0.8743169398907104 0.3058667473781962 Q8IV35, Q9QXL2, Q5F3X8, Q6VNB8, Q8K4Q0, P55884, Q4V8C4, Q8K4K5 151 53 1448 1.4474572035486695 1.0 0.9998345555481242 99.62728138398572 INTERPRO IPR001680:WD40 repeat 8 0.8743169398907104 0.3641981960373605 Q8IV35, Q9QXL2, Q5F3X8, Q6VNB8, Q8K4Q0, O42249, Q4V8C4, Q8K4K5 166 55 1556 1.3634173055859802 1.0 0.9742851383102004 99.81426987673039 SMART SM00320:WD40 8 0.8743169398907104 0.6339449629448715 Q8IV35, Q9QXL2, Q5F3X8, Q6VNB8, Q8K4Q0, O42249, Q4V8C4, Q8K4K5 114 55 836 1.0666666666666667 1.0 0.9980321698913689 99.9990878238896 INTERPRO IPR020472:G-protein beta WD-40 repeat 3 0.32786885245901637 0.6955528746427198 Q8IV35, O42249, Q4V8C4 166 22 1556 1.2782037239868564 1.0 0.9998344545904493 99.99999327129392 Annotation Cluster 13 Enrichment Score: 0.5768359204255031 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_DIRECT GO:0012507~ER to Golgi transport vesicle membrane 3 0.32786885245901637 0.05764527318333358 O95487, Q5F3X8, P53992 157 4 1477 7.055732484076433 0.9999986790504448 0.9890277571585693 53.23951566169445 GOTERM_CC_DIRECT GO:0005789~endoplasmic reticulum membrane 8 0.8743169398907104 0.25408080664494165 O95487, Q3UR85, Q8K2W3, Q9UUH0, Q05609, Q5F3X8, Q80TE7, P53992 157 49 1477 1.5359417652411282 1.0 0.9941492745575492 97.65506138313341 GOTERM_CC_DIRECT GO:0048471~perinuclear region of cytoplasm 8 0.8743169398907104 0.25408080664494165 Q12829, O95487, Q80TP3, P28828, Q5F3X8, P53992, P28827, Q06486 157 49 1477 1.5359417652411282 1.0 0.9941492745575492 97.65506138313341 UP_KEYWORDS ER-Golgi transport 3 0.32786885245901637 0.3274930551143232 O95487, Q5F3X8, P53992 172 11 1616 2.5623678646934462 1.0 0.8439342435108534 99.32406105517353 GOTERM_BP_DIRECT GO:0006888~ER to Golgi vesicle-mediated transport 3 0.32786885245901637 0.39171073357512015 O95487, Q9UUH0, P53992 158 12 1414 2.2373417721518987 1.0 0.99999986808013 99.95939604667704 UP_KEYWORDS Endoplasmic reticulum 8 0.8743169398907104 0.7246186204815604 O95487, Q3UR85, Q8K2W3, Q9UUH0, Q5F3X8, O75581, P53992, Q91W90 172 77 1616 0.9761401389308366 1.0 0.9821385383713136 99.99999116528743 Annotation Cluster 14 Enrichment Score: 0.47290031384947784 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_DIRECT GO:0045893~positive regulation of transcription, DNA-templated 8 0.8743169398907104 0.023658308740738297 P0C8Z3, Q3UR85, Q80Z37, Q8WYB5, O35261, O75581, P91943, Q3TKT4 158 27 1414 2.6516643225503986 0.9999999998853553 0.9995142069072567 31.347817042022964 UP_KEYWORDS Chromatin regulator 8 0.8743169398907104 0.038405662857775066 P0C8Z3, Q8WYB5, B4NKI9, Q6N021, Q15906, E1C2V1, Q6DC04, Q3TKT4 172 31 1616 2.4246061515378843 0.9996864326749595 0.6841536745127874 38.93539972460155 UP_KEYWORDS Activator 10 1.092896174863388 0.10890828573336434 Q8NI08, P0C8Z3, Q3UR85, Q8WYB5, P27641, O35261, P91943, Q9GPH3, Q3TKT4, O70230 172 54 1616 1.7398794142980187 0.9999999999516924 0.7734046621844723 76.5958940956244 GOTERM_MF_DIRECT GO:0003700~transcription factor activity, sequence-specific DNA binding 7 0.7650273224043715 0.4891536595368419 Q3UR85, Q14590, Q6NYU2, O35261, P10076, Q9GPH3, E1C2V1 152 50 1357 1.2498684210526314 1.0 0.9993029175118681 99.9875272428356 UP_KEYWORDS Transcription regulation 17 1.8579234972677594 0.7388983998518501 Q96EB6, P0C8Z3, Q14590, O35261, E1C2V1, Q9GPH3, Q96FV9, Q3TKT4, Q8NI08, Q3UR85, Q8WYB5, P27641, P91943, B4NKI9, Q15906, Q6DC04, O70230 172 170 1616 0.9395348837209302 1.0 0.9838969951573383 99.99999548204904 UP_KEYWORDS Transcription 17 1.8579234972677594 0.8037021482911489 Q96EB6, P0C8Z3, Q14590, O35261, E1C2V1, Q9GPH3, Q96FV9, Q3TKT4, Q8NI08, Q3UR85, Q8WYB5, P27641, P91943, B4NKI9, Q15906, Q6DC04, O70230 172 178 1616 0.8973085968121244 1.0 0.9892445207904474 99.99999987567895 GOTERM_BP_DIRECT GO:0006355~regulation of transcription, DNA-templated 14 1.530054644808743 0.8201733862377012 P0C8Z3, Q14590, O35261, E1C2V1, Q3TKT4, Q3UR85, Q8WYB5, Q6NYU2, P27641, P10076, P91943, B4NKI9, Q6DC04, O70230 158 142 1414 0.882331966482439 1.0 0.9999999999999357 99.99999999980301 GOTERM_BP_DIRECT GO:0006351~transcription, DNA-templated 15 1.639344262295082 0.8915167321346374 Q96EB6, Q8NI08, P0C8Z3, Q3UR85, Q14590, Q8WYB5, P27641, O35261, B4NKI9, E1C2V1, Q9GPH3, Q15906, Q6DC04, Q3TKT4, O70230 158 163 1414 0.8235613885221714 1.0 0.9999999999999999 99.99999999999993 GOTERM_MF_DIRECT GO:0003677~DNA binding 12 1.3114754098360655 0.9416486277560275 Q3UR85, Q80Z37, Q14590, Q8WYB5, Q6NYU2, P27641, O35261, P10076, Q6N021, Q15906, Q96FV9, O70230 152 143 1357 0.7491718807508281 1.0 0.9999999987470323 100.0 UP_KEYWORDS DNA-binding 11 1.2021857923497268 0.9429914777424191 Q3UR85, Q14590, P27641, O35261, P10076, P91943, Q6N021, Q15906, Q9GPH3, Q96FV9, O70230 172 140 1616 0.7382059800664452 1.0 0.9993143637504014 99.99999999999997 Annotation Cluster 15 Enrichment Score: 0.43833123557501114 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000504:RNA recognition motif domain 7 0.7650273224043715 0.2083634731147549 Q80VC6, Q8IZ69, Q96EV2, E1BZ85, Q06AA4, Q3T106, P55884 166 38 1556 1.7266962587190868 1.0 0.8963186841628441 96.10141388741718 GOTERM_MF_DIRECT GO:0000166~nucleotide binding 15 1.639344262295082 0.27099567949930914 Q80VC6, Q8IZ69, Q86WJ1, Q3T106, Q3TKT4, P55884, Q96EV2, Q23551, Q9QXL2, Q4QY64, P27641, Q6NYU2, E1BZ85, Q8BKX6, Q06AA4 152 105 1357 1.275375939849624 1.0 0.9935299689220318 98.54495547704526 INTERPRO IPR012677:Nucleotide-binding, alpha-beta plait 7 0.7650273224043715 0.3013540520045587 Q80VC6, Q8IZ69, Q96EV2, E1BZ85, Q06AA4, Q3T106, P55884 166 43 1556 1.5259176239843093 1.0 0.95143282175766 99.31242477351731 UP_SEQ_FEATURE domain:RRM 4 0.4371584699453552 0.34352014562911853 Q8IZ69, Q96EV2, Q3T106, P55884 151 20 1448 1.917880794701987 1.0 0.9999223587182007 99.84137145789099 UP_KEYWORDS RNA-binding 12 1.3114754098360655 0.4523727244945308 Q6ZWX6, Q80VC6, Q8IZ69, Q96EV2, Q86Y13, E1BZ85, Q7L014, Q96FV9, Q06AA4, Q3T106, P55884, Q7SXM7 172 97 1616 1.16231119635579 1.0 0.9204628748662548 99.94914653400204 GOTERM_MF_DIRECT GO:0003723~RNA binding 9 0.9836065573770493 0.5607127600996711 Q6ZWX6, Q80VC6, Q80TP3, Q86Y13, E1BZ85, Q96FV9, Q06AA4, P55884, Q7SXM7 152 72 1357 1.115953947368421 1.0 0.9997535318855706 99.9983449980919 SMART SM00360:RRM 6 0.6557377049180327 0.576277015884892 Q80VC6, Q96EV2, E1BZ85, Q06AA4, Q3T106, P55884 114 37 836 1.189189189189189 1.0 0.9963168490931705 99.99505970891452 Annotation Cluster 16 Enrichment Score: 0.4235144599142662 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_KEYWORDS NAD 5 0.546448087431694 0.15337791672114734 Q96EB6, A8DZE7, Q83F39, P12276, P50365 172 20 1616 2.3488372093023253 0.9999999999999988 0.8047147980650831 87.71773767019373 INTERPRO IPR016040:NAD(P)-binding domain 4 0.4371584699453552 0.5045179475553495 A8DZE7, Q83F39, P12276, Q5R9W5 166 25 1556 1.4997590361445785 1.0 0.9952156789588925 99.99417775775197 UP_KEYWORDS Oxidoreductase 6 0.6557377049180327 0.6931339405172862 A8DZE7, Q83F39, P12276, Q5R9W5, Q6N021, P50365 172 54 1616 1.0439276485788114 1.0 0.9789910572549355 99.99996546025123 Annotation Cluster 17 Enrichment Score: 0.42129536741137347 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_KEYWORDS Zinc 29 3.169398907103825 0.26035565423385015 Q83F39, Q14590, Q86Y13, D2GXS7, P63329, A4IF63, Q80TP3, Q8WYB5, Q6NYU2, Q9U489, P10076, Q9R1R2, Q6VNB8, O70230, Q96EB6, O75382, O88427, P0C8Z3, Q80Z37, Q4R550, Q9VXF1, E1C2V1, Q5F408, Q3T106, O70277, P58283, A9CPT4, Q6N021, A9JTP3 172 234 1616 1.1643808387994434 1.0 0.839145536359221 97.75924393514866 UP_KEYWORDS Metal-binding 42 4.590163934426229 0.31614871678095263 Q9UPN3, Q83F39, Q14590, P62714, Q86Y13, D2GXS7, Q8Z3G5, Q93075, P63329, Q5ZM73, A4IF63, Q80TP3, Q8WYB5, Q6NYU2, Q9U489, P10076, Q6VNB8, Q9R1R2, Q96Q15, O70230, Q86SG6, Q96EB6, O75382, O88427, Q6DDU8, P0C8Z3, Q80Z37, O95749, Q4R550, Q9VXF1, Q8BGQ6, Q5F408, E1C2V1, Q3T106, O70277, P58283, P56966, Q23551, Q8BKX6, A9CPT4, Q6N021, A9JTP3 172 360 1616 1.0961240310077518 1.0 0.851822246659727 99.16553911645609 UP_KEYWORDS Zinc-finger 21 2.2950819672131146 0.4110121903335951 O75382, P0C8Z3, Q80Z37, Q14590, Q86Y13, D2GXS7, E1C2V1, Q3T106, O70277, P58283, A4IF63, Q80TP3, Q8WYB5, Q6NYU2, Q9U489, P10076, A9CPT4, A9JTP3, Q9R1R2, Q6VNB8, O70230 172 177 1616 1.114702404414663 1.0 0.9065722118890928 99.87277343684148 GOTERM_MF_DIRECT GO:0046872~metal ion binding 27 2.9508196721311477 0.610246630593499 Q14590, P62714, Q8Z3G5, P63329, Q93075, Q80TP3, Q6NYU2, Q9U489, P10076, Q96Q15, Q9R1R2, Q6VNB8, O70230, Q86SG6, Q96EB6, O88427, Q80Z37, Q4R550, O95749, Q8BGQ6, Q9VXF1, Q5F408, P58283, P56966, Q23551, A9CPT4, Q8BKX6 152 241 1357 1.000191089757589 1.0 0.99986655827098 99.99966625122048 Annotation Cluster 18 Enrichment Score: 0.4157315738680153 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011992:EF-hand-like domain 6 0.6557377049180327 0.20583138536476758 Q8IV35, Q9UPN3, Q2IA00, Q9R095, Q8BGQ6, Q5ZM73 166 30 1556 1.8746987951807228 1.0 0.899014300164653 95.92464107826355 UP_SEQ_FEATURE domain:EF-hand 2 3 0.32786885245901637 0.4707897544510433 Q9UPN3, Q8BGQ6, Q5ZM73 151 15 1448 1.917880794701987 1.0 0.9999933729582461 99.9941545834056 UP_SEQ_FEATURE domain:EF-hand 1 3 0.32786885245901637 0.4707897544510433 Q9UPN3, Q8BGQ6, Q5ZM73 151 15 1448 1.917880794701987 1.0 0.9999933729582461 99.9941545834056 INTERPRO IPR002048:EF-hand domain 4 0.4371584699453552 0.4763301827270796 Q8IV35, Q9UPN3, Q8BGQ6, Q5ZM73 166 24 1556 1.5622489959839359 1.0 0.9933947914352613 99.9874463264545 Annotation Cluster 19 Enrichment Score: 0.36691009123313 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:LRR 1 6 0.6557377049180327 0.15622089280866802 Q7KRY7, Q2IA00, Q9R095, Q80TE7, Q6VNB8, Q8BH70 151 28 1448 2.054872280037843 1.0 0.9970095201908808 92.58610421390132 UP_SEQ_FEATURE repeat:LRR 2 6 0.6557377049180327 0.15622089280866802 Q7KRY7, Q2IA00, Q9R095, Q80TE7, Q6VNB8, Q8BH70 151 28 1448 2.054872280037843 1.0 0.9970095201908808 92.58610421390132 UP_SEQ_FEATURE repeat:LRR 8 3 0.32786885245901637 0.35770997542161886 Q7KRY7, Q80TE7, Q8BH70 151 12 1448 2.3973509933774837 1.0 0.9999186438907486 99.88649379741337 UP_SEQ_FEATURE repeat:LRR 7 3 0.32786885245901637 0.4707897544510433 Q7KRY7, Q80TE7, Q8BH70 151 15 1448 1.917880794701987 1.0 0.9999933729582461 99.9941545834056 UP_KEYWORDS Leucine-rich repeat 4 0.4371584699453552 0.6071566259067177 Q7KRY7, Q9UPN3, Q80TE7, Q8BH70 172 29 1616 1.2959101844426624 1.0 0.9616992893533305 99.99922491271607 UP_SEQ_FEATURE repeat:LRR 6 3 0.32786885245901637 0.6302180731078515 Q7KRY7, Q80TE7, Q8BH70 151 20 1448 1.4384105960264901 1.0 0.9999999594384863 99.9999758883686 UP_SEQ_FEATURE repeat:LRR 5 3 0.32786885245901637 0.6572690348618485 Q7KRY7, Q80TE7, Q8BH70 151 21 1448 1.3699148533585621 1.0 0.9999999836716552 99.9999924684708 UP_SEQ_FEATURE repeat:LRR 4 3 0.32786885245901637 0.682726700656883 Q7KRY7, Q80TE7, Q8BH70 151 22 1448 1.3076459963877183 1.0 0.9999999933075187 99.99999769080665 UP_SEQ_FEATURE repeat:LRR 3 3 0.32786885245901637 0.7066286485462248 Q7KRY7, Q80TE7, Q8BH70 151 23 1448 1.2507918226317305 1.0 0.9999999972069665 99.99999930427096 Annotation Cluster 20 Enrichment Score: 0.3372098357807386 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_KEYWORDS Cell junction 8 0.8743169398907104 0.22267105036619325 Q7KRY7, Q15262, Q9BTW9, P20241, Q80TE7, Q00174, Q9NRA2, D3YXG0 172 47 1616 1.599208312716477 1.0 0.8329228128951974 95.81003615432827 GOTERM_CC_DIRECT GO:0030054~cell junction 4 0.4371584699453552 0.6297334201778122 Q80TE7, Q00174, Q9NRA2, D3YXG0 157 30 1477 1.2543524416135883 1.0 0.9997728332372811 99.99970084937628 UP_KEYWORDS Synapse 3 0.32786885245901637 0.6943045204210974 Q80TE7, Q00174, Q9NRA2 172 22 1616 1.2811839323467231 1.0 0.9779568313931764 99.99996708346339 Annotation Cluster 21 Enrichment Score: 0.31508373483486657 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_DIRECT GO:0005913~cell-cell adherens junction 5 0.546448087431694 0.2428402378553044 Q9UPN3, P28828, P28827, Q8N392, Q06486 157 24 1477 1.9599256900212314 1.0 0.9968675301096661 97.16016244063438 GOTERM_BP_DIRECT GO:0098609~cell-cell adhesion 3 0.32786885245901637 0.6696975903615795 Q9UPN3, Q8N392, Q06486 158 20 1414 1.3424050632911393 1.0 0.9999999998361448 99.99999722958856 GOTERM_MF_DIRECT GO:0098641~cadherin binding involved in cell-cell adhesion 3 0.32786885245901637 0.6975083477757452 Q9UPN3, Q8N392, Q06486 152 21 1357 1.2753759398496238 1.0 0.9999574070487444 99.9999887737818 Annotation Cluster 22 Enrichment Score: 0.3113774678496815 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_KEYWORDS Endosome 8 0.8743169398907104 0.27295116865112834 O75382, Q8CI95, Q5VV43, F1Q506, Q9R1R2, O70277, Q8K4K5, A1A4L0 172 50 1616 1.5032558139534884 1.0 0.8468197446147845 98.19512631395149 UP_KEYWORDS Lipid-binding 3 0.32786885245901637 0.6135697336023569 Q8CI95, F1Q506, A1A4L0 172 19 1616 1.4834761321909424 1.0 0.961781154734836 99.99937002899671 GOTERM_CC_DIRECT GO:0005768~endosome 4 0.4371584699453552 0.6948942369820607 Q8CI95, F1Q506, Q9R1R2, A1A4L0 157 33 1477 1.1403204014668982 1.0 0.9998384838605581 99.99997490103091 Annotation Cluster 23 Enrichment Score: 0.11823837989062351 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_KEYWORDS Ribonucleoprotein 5 0.546448087431694 0.6653197124177719 Q9VE04, Q9VCX3, P02362, Q06AA4, Q7SXM7 172 42 1616 1.1184939091915838 1.0 0.973664274779655 99.99989698504159 UP_KEYWORDS Ribosomal protein 3 0.32786885245901637 0.7798646488597394 Q9VE04, Q9VCX3, P02362 172 26 1616 1.0840787119856887 1.0 0.9876156104551417 99.99999947345924 GOTERM_MF_DIRECT GO:0003735~structural constituent of ribosome 3 0.32786885245901637 0.8515991806423164 Q9VE04, Q9VCX3, P02362 152 29 1357 0.9235480943738656 1.0 0.9999992471435779 99.99999999918514 Annotation Cluster 24 Enrichment Score: 0.1101612207637914 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_KEYWORDS mRNA splicing 5 0.546448087431694 0.6653197124177719 Q7L014, Q96FV9, Q06AA4, Q3T106, Q7SXM7 172 42 1616 1.1184939091915838 1.0 0.973664274779655 99.99989698504159 GOTERM_BP_DIRECT GO:0000398~mRNA splicing, via spliceosome 3 0.32786885245901637 0.7209479086982988 Q7L014, Q06AA4, Q7SXM7 158 22 1414 1.2203682393555813 1.0 0.9999999999846818 99.99999980401462 UP_KEYWORDS mRNA processing 5 0.546448087431694 0.8187101765278881 Q7L014, Q96FV9, Q06AA4, Q3T106, Q7SXM7 172 52 1616 0.9033989266547405 1.0 0.9902320898769411 99.99999995434378 GOTERM_BP_DIRECT GO:0008380~RNA splicing 3 0.32786885245901637 0.9231890629795654 Q96FV9, Q3T106, Q7SXM7 158 36 1414 0.7457805907172995 1.0 1.0 100.0 Annotation Cluster 25 Enrichment Score: 0.09377471439749077 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_KEYWORDS Cell cycle 8 0.8743169398907104 0.5923313061048927 Q6DF94, P0C8Z3, Q3B7D5, O35261, Q6N021, Q96AY4, O75943, D3YXG0 172 68 1616 1.1053351573187413 1.0 0.9587029289316774 99.99876413263434 UP_KEYWORDS Cell division 3 0.32786885245901637 0.9368934453487603 Q6DF94, Q96AY4, D3YXG0 172 40 1616 0.7046511627906976 1.0 0.9991868105029713 99.99999999999993 GOTERM_BP_DIRECT GO:0051301~cell division 3 0.32786885245901637 0.9428030297940958 Q6DF94, Q96AY4, D3YXG0 158 39 1414 0.688412852969815 1.0 1.0 100.0 Annotation Cluster 26 Enrichment Score: 0.044121855039247905 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:C2H2-type 7 3 0.32786885245901637 0.7877106559662482 Q14590, P10076, O70230 151 27 1448 1.0654893303899926 1.0 0.9999999999349396 99.99999999509586 UP_SEQ_FEATURE zinc finger region:C2H2-type 6 3 0.32786885245901637 0.7877106559662482 Q14590, P10076, O70230 151 27 1448 1.0654893303899926 1.0 0.9999999999349396 99.99999999509586 UP_SEQ_FEATURE zinc finger region:C2H2-type 5 3 0.32786885245901637 0.8725957100459999 Q14590, P10076, O70230 151 33 1448 0.8717639975918122 1.0 0.9999999999999091 99.99999999999804 UP_SEQ_FEATURE zinc finger region:C2H2-type 4 3 0.32786885245901637 0.8832790752197675 Q14590, P10076, O70230 151 34 1448 0.8461238800155825 1.0 0.9999999999999224 99.99999999999949 UP_SEQ_FEATURE zinc finger region:C2H2-type 2 3 0.32786885245901637 0.910578977184689 Q14590, P10076, O70230 151 37 1448 0.7775192410954 1.0 0.9999999999999967 99.99999999999999 UP_SEQ_FEATURE zinc finger region:C2H2-type 3 3 0.32786885245901637 0.910578977184689 Q14590, P10076, O70230 151 37 1448 0.7775192410954 1.0 0.9999999999999967 99.99999999999999 INTERPRO IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain 3 0.32786885245901637 0.9611343461907851 Q14590, P10076, O70230 166 45 1556 0.6248995983935742 1.0 0.9999999998877906 100.0 INTERPRO IPR015880:Zinc finger, C2H2-like 3 0.32786885245901637 0.9760920961212727 Q14590, P10076, O70230 166 50 1556 0.5624096385542169 1.0 0.9999999999941708 100.0 INTERPRO IPR007087:Zinc finger, C2H2 3 0.32786885245901637 0.9783313593870824 Q14590, P10076, O70230 166 51 1556 0.5513819985825655 1.0 0.9999999999953013 100.0 SMART SM00355:ZnF_C2H2 3 0.32786885245901637 0.9948117043059017 Q14590, P10076, O70230 114 50 836 0.44 1.0 0.9999999999998679 100.0