ID Gene Name Species BIOCARTA COG_ONTOLOGY GOTERM_BP_DIRECT GOTERM_CC_DIRECT GOTERM_MF_DIRECT INTERPRO KEGG_PATHWAY OMIM_DISEASE PIR_SUPERFAMILY SMART UP_KEYWORDS UP_SEQ_FEATURE P09087 Abdominal B(Abd-B) Drosophila melanogaster GO:0006355~regulation of transcription, DNA-templated,GO:0007280~pole cell migration,GO:0007379~segment specification,GO:0007385~specification of segmental identity, abdomen,GO:0007424~open tracheal system development,GO:0007431~salivary gland development,GO:0007484~imaginal disc-derived genitalia development,GO:0007486~imaginal disc-derived female genitalia development,GO:0007494~midgut development,GO:0007506~gonadal mesoderm development,GO:0007507~heart development,GO:0007548~sex differentiation,GO:0007621~negative regulation of female receptivity,GO:0008354~germ cell migration,GO:0008584~male gonad development,GO:0009997~negative regulation of cardioblast cell fate specification,GO:0030539~male genitalia development,GO:0030540~female genitalia development,GO:0035215~genital disc development,GO:0035224~genital disc anterior/posterior pattern formation,GO:0035225~determination of genital disc primordium,GO:0035261~external genitalia morphogenesis,GO:0035263~genital disc sexually dimorphic development,GO:0035277~spiracle morphogenesis, open tracheal system,GO:0045705~negative regulation of salivary gland boundary specification,GO:0045843~negative regulation of striated muscle tissue development,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0046693~sperm storage,GO:0048066~developmental pigmentation,GO:0048071~sex-specific pigmentation,GO:0048087~positive regulation of developmental pigmentation,GO:0048094~male pigmentation,GO:0060439~trachea morphogenesis,GO:0061101~neuroendocrine cell differentiation,GO:1902339~positive regulation of apoptotic process involved in morphogenesis, GO:0005634~nucleus, GO:0000976~transcription regulatory region sequence-specific DNA binding,GO:0000980~RNA polymerase II distal enhancer sequence-specific DNA binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0043565~sequence-specific DNA binding, IPR001356:Homeodomain,IPR009057:Homeodomain-like,IPR017970:Homeobox, conserved site,IPR020479:Homeodomain, metazoa, SM00389:HOX, Alternative splicing,Coiled coil,Complete proteome,Developmental protein,DNA-binding,Homeobox,Nucleus,Reference proteome, chain:Homeobox protein abdominal-B,compositionally biased region:Gln-rich,compositionally biased region:Poly-Ala,compositionally biased region:Poly-Asn,DNA-binding region:Homeobox,sequence conflict,splice variant, A3KPW9 BCL2-associated athanogene 6, like(bag6l) Danio rerio GO:0001822~kidney development,GO:0006511~ubiquitin-dependent protein catabolic process,GO:0006810~transport,GO:0007130~synaptonemal complex assembly,GO:0007283~spermatogenesis,GO:0007420~brain development,GO:0009790~embryo development,GO:0016569~covalent chromatin modification,GO:0018393~internal peptidyl-lysine acetylation,GO:0030324~lung development,GO:0032435~negative regulation of proteasomal ubiquitin-dependent protein catabolic process,GO:0042771~intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator,GO:0042981~regulation of apoptotic process,GO:0045861~negative regulation of proteolysis,GO:0050821~protein stabilization,GO:0070059~intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress,GO:0071816~tail-anchored membrane protein insertion into ER membrane, GO:0005634~nucleus,GO:0005829~cytosol,GO:0071818~BAT3 complex, GO:0031593~polyubiquitin binding,GO:0043022~ribosome binding,GO:0070628~proteasome binding, IPR000626:Ubiquitin,IPR021925:Protein of unknown function DUF3538, SM00213:UBQ, Apoptosis,Chaperone,Chromatin regulator,Complete proteome,Cytoplasm,Nucleus,Proteomics identification,Reference proteome,Transport, O14867 BTB domain and CNC homolog 1(BACH1) Homo sapiens GO:0000083~regulation of transcription involved in G1/S transition of mitotic cell cycle,GO:0000117~regulation of transcription involved in G2/M transition of mitotic cell cycle,GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0006281~DNA repair,GO:0006302~double-strand break repair,GO:0006310~DNA recombination,GO:0006355~regulation of transcription, DNA-templated,GO:0006366~transcription from RNA polymerase II promoter,GO:0016567~protein ubiquitination,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0061418~regulation of transcription from RNA polymerase II promoter in response to hypoxia, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0031463~Cul3-RING ubiquitin ligase complex, GO:0000980~RNA polymerase II distal enhancer sequence-specific DNA binding,GO:0001078~transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding,GO:0001205~transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding,GO:0001206~transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0020037~heme binding,GO:0043565~sequence-specific DNA binding, IPR000210:BTB/POZ-like,IPR004826:Basic leucine zipper domain, Maf-type,IPR004827:Basic-leucine zipper domain,IPR008917:Eukaryotic transcription factor, Skn-1-like, DNA-binding,IPR011333:BTB/POZ fold, SM00225:BTB,SM00338:BRLZ, 3D-structure,Activator,Complete proteome,DNA-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repressor,Transcription,Transcription regulation, chain:Transcription regulator protein BACH1,DNA-binding region:Basic motif,domain:BTB,domain:Leucine-zipper,helix,modified residue,sequence conflict,sequence variant,strand,turn, Q5R7D0 COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)(COX18) Pongo abelii GO:0008535~respiratory chain complex IV assembly,GO:0051204~protein insertion into mitochondrial membrane,GO:0051205~protein insertion into membrane, GO:0016021~integral component of membrane,GO:0031305~integral component of mitochondrial inner membrane, GO:0008565~protein transporter activity, IPR001708:Membrane insertase OXA1/ALB3/YidC, Complete proteome,Membrane,Mitochondrion,Mitochondrion inner membrane,Reference proteome,Transit peptide,Transmembrane,Transmembrane helix, chain:Mitochondrial inner membrane protein cox18,transit peptide:Mitochondrion,transmembrane region, Q5BJ29 F-box and leucine-rich repeat protein 7(Fbxl7) Mus musculus GO:0000086~G2/M transition of mitotic cell cycle,GO:0007049~cell cycle,GO:0007067~mitotic nuclear division,GO:0008283~cell proliferation,GO:0016567~protein ubiquitination,GO:0031146~SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,GO:0051301~cell division, GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005856~cytoskeleton,GO:0016021~integral component of membrane,GO:0019005~SCF ubiquitin ligase complex, GO:0005515~protein binding, IPR001611:Leucine-rich repeat,IPR001810:F-box domain, cyclin-like,IPR006553:Leucine-rich repeat, cysteine-containing subtype, SM00256:FBOX,SM00367:LRR_CC, Cell cycle,Cell division,Complete proteome,Cytoplasm,Cytoskeleton,Leucine-rich repeat,Membrane,Mitosis,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Ubl conjugation pathway, chain:F-box/LRR-repeat protein 7,domain:F-box,repeat:LRR 1,repeat:LRR 10,repeat:LRR 2,repeat:LRR 3,repeat:LRR 4,repeat:LRR 5,repeat:LRR 6,repeat:LRR 7,repeat:LRR 8,repeat:LRR 9, Q5MNV8 F-box protein 47(FBXO47) Homo sapiens IPR001810:F-box domain, cyclin-like, Complete proteome,Polymorphism,Reference proteome,Ubl conjugation pathway, chain:F-box only protein 47,domain:F-box,sequence variant, Q68DX3 FERM and PDZ domain containing 2(FRMPD2) Homo sapiens GO:0070830~bicellular tight junction assembly, GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005923~bicellular tight junction,GO:0016323~basolateral plasma membrane, GO:0005515~protein binding,GO:0005545~1-phosphatidylinositol binding, IPR000299:FERM domain,IPR001478:PDZ domain,IPR011019:KIND,IPR011993:Pleckstrin homology-like domain,IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle,IPR018979:FERM, N-terminal,IPR018980:FERM, C-terminal PH-like domain,IPR019748:FERM central domain,IPR019749:Band 4.1 domain, SM00228:PDZ,SM00295:B41,SM00750:KIND,SM01196:SM01196, Alternative splicing,Cell junction,Cell membrane,Complete proteome,Cytoplasm,Membrane,Polymorphism,Proteomics identification,Reference proteome,Repeat,Tight junction, chain:FERM and PDZ domain-containing protein 2,chain:Putative protein FRMPD2-like,domain:FERM,domain:KIND,domain:PDZ 1,domain:PDZ 2,domain:PDZ 3,sequence conflict,sequence variant,splice variant, Q2YDL5 FK506 binding protein 11(FKBP11) Bos taurus GO:0000413~protein peptidyl-prolyl isomerization,GO:0006457~protein folding,GO:0061077~chaperone-mediated protein folding, GO:0005789~endoplasmic reticulum membrane,GO:0016021~integral component of membrane, GO:0003755~peptidyl-prolyl cis-trans isomerase activity,GO:0005528~FK506 binding, IPR001179:Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain,IPR023566:Peptidyl-prolyl cis-trans isomerase, FKBP-type, Complete proteome,Isomerase,Membrane,Proteomics identification,Reference proteome,Rotamase,Signal,Transmembrane,Transmembrane helix, chain:FK506-binding protein 11,domain:PPIase FKBP-type,signal peptide,transmembrane region, Q9VZW5 FMRFamide Receptor(FMRFaR) Drosophila melanogaster GO:0002209~behavioral defense response,GO:0007186~G-protein coupled receptor signaling pathway,GO:0007204~positive regulation of cytosolic calcium ion concentration,GO:0007218~neuropeptide signaling pathway,GO:0008344~adult locomotory behavior,GO:0008345~larval locomotory behavior, GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane, GO:0001653~peptide receptor activity,GO:0004930~G-protein coupled receptor activity,GO:0008188~neuropeptide receptor activity,GO:0008528~G-protein coupled peptide receptor activity, IPR000276:G protein-coupled receptor, rhodopsin-like,IPR017452:GPCR, rhodopsin-like, 7TM,IPR019427:7TM GPCR, serpentine receptor class w (Srw), Cell membrane,Complete proteome,G-protein coupled receptor,Glycoprotein,Membrane,Receptor,Reference proteome,Transducer,Transmembrane,Transmembrane helix, chain:FMRFamide receptor,compositionally biased region:Poly-Gly,glycosylation site:N-linked (GlcNAc...),topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, P30731 G protein-coupled receptor 83(Gpr83) Mus musculus GO:0007165~signal transduction,GO:0007166~cell surface receptor signaling pathway,GO:0007186~G-protein coupled receptor signaling pathway,GO:0051384~response to glucocorticoid, GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0031513~nonmotile primary cilium, GO:0004871~signal transducer activity,GO:0004930~G-protein coupled receptor activity,GO:0004983~neuropeptide Y receptor activity, IPR000276:G protein-coupled receptor, rhodopsin-like,IPR000611:Neuropeptide Y receptor family,IPR017452:GPCR, rhodopsin-like, 7TM, mmu04080:Neuroactive ligand-receptor interaction, SM01381:SM01381, Alternative splicing,Cell membrane,Complete proteome,Disulfide bond,G-protein coupled receptor,Glycoprotein,Membrane,Receptor,Reference proteome,Signal,Transducer,Transmembrane,Transmembrane helix, chain:Probable G-protein coupled receptor 83,disulfide bond,glycosylation site:N-linked (GlcNAc...),signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q9LU92 Homeodomain-like superfamily protein(AT3G25990) Arabidopsis thaliana GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005634~nucleus, GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding, IPR001005:SANT/Myb domain,IPR009057:Homeodomain-like,IPR017877:Myb-like domain, SM00717:SANT, Complete proteome,DNA-binding,Nucleus,Phosphoprotein,Reference proteome,Transcription,Transcription regulation, P34416 LIM and SH3 domain protein F42H10.3(F42H10.3) Caenorhabditis elegans GO:0030054~cell junction,GO:0055120~striated muscle dense body, GO:0008270~zinc ion binding,GO:0046872~metal ion binding, IPR000900:Nebulin 35 residue motif,IPR001452:Src homology-3 domain,IPR001781:Zinc finger, LIM-type, SM00132:LIM,SM00227:NEBU,SM00326:SH3, Complete proteome,LIM domain,Metal-binding,Proteomics identification,Reference proteome,Repeat,SH3 domain,Zinc, chain:LIM and SH3 domain protein F42H10.3,domain:LIM zinc-binding,domain:SH3,repeat:Nebulin 1,repeat:Nebulin 2, Q08B72 Myb-related transcription factor, partner of profilin L homeolog(mypop.L) Xenopus laevis GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005634~nucleus, GO:0003677~DNA binding, IPR009057:Homeodomain-like,IPR017877:Myb-like domain, DNA-binding,Nucleus,Repressor,Transcription,Transcription regulation, chain:Myb-related transcription factor, partner of profilin,compositionally biased region:Pro-rich,domain:Myb-like, P56941 NPC intracellular cholesterol transporter 1(NPC1) Sus scrofa GO:0006486~protein glycosylation,GO:0006897~endocytosis,GO:0006914~autophagy,GO:0007041~lysosomal transport,GO:0007628~adult walking behavior,GO:0008203~cholesterol metabolic process,GO:0008206~bile acid metabolic process,GO:0016242~negative regulation of macroautophagy,GO:0030301~cholesterol transport,GO:0031579~membrane raft organization,GO:0033344~cholesterol efflux,GO:0042493~response to drug,GO:0042632~cholesterol homeostasis,GO:0046718~viral entry into host cell,GO:0071383~cellular response to steroid hormone stimulus,GO:0071404~cellular response to low-density lipoprotein particle stimulus,GO:0090150~establishment of protein localization to membrane,GO:2000189~positive regulation of cholesterol homeostasis, GO:0005576~extracellular region,GO:0005635~nuclear envelope,GO:0005764~lysosome,GO:0005765~lysosomal membrane,GO:0005768~endosome,GO:0005783~endoplasmic reticulum,GO:0005794~Golgi apparatus,GO:0005887~integral component of plasma membrane,GO:0031902~late endosome membrane,GO:0045121~membrane raft,GO:0048471~perinuclear region of cytoplasm,GO:0070062~extracellular exosome, GO:0005319~lipid transporter activity,GO:0015485~cholesterol binding, IPR000731:Sterol-sensing domain,IPR003392:Patched,IPR004765:Niemann-Pick C type protein, ssc04142:Lysosome, Cholesterol metabolism,Complete proteome,Disulfide bond,Endosome,Glycoprotein,Lipid metabolism,Lysosome,Membrane,Proteomics identification,Reference proteome,Signal,Steroid metabolism,Sterol metabolism,Transmembrane,Transmembrane helix, chain:Niemann-Pick C1 protein,compositionally biased region:Poly-Pro,domain:SSD,glycosylation site:N-linked (GlcNAc...),short sequence motif:Di-leucine motif,signal peptide,transmembrane region, O15118 NPC intracellular cholesterol transporter 1(NPC1) Homo sapiens GO:0006486~protein glycosylation,GO:0006897~endocytosis,GO:0006914~autophagy,GO:0007041~lysosomal transport,GO:0007165~signal transduction,GO:0007628~adult walking behavior,GO:0008203~cholesterol metabolic process,GO:0008206~bile acid metabolic process,GO:0016242~negative regulation of macroautophagy,GO:0030301~cholesterol transport,GO:0031579~membrane raft organization,GO:0033344~cholesterol efflux,GO:0042493~response to drug,GO:0042632~cholesterol homeostasis,GO:0046686~response to cadmium ion,GO:0046718~viral entry into host cell,GO:0060548~negative regulation of cell death,GO:0071383~cellular response to steroid hormone stimulus,GO:0071404~cellular response to low-density lipoprotein particle stimulus,GO:0090150~establishment of protein localization to membrane,GO:2000189~positive regulation of cholesterol homeostasis, GO:0005576~extracellular region,GO:0005635~nuclear envelope,GO:0005764~lysosome,GO:0005765~lysosomal membrane,GO:0005783~endoplasmic reticulum,GO:0005794~Golgi apparatus,GO:0005887~integral component of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0031902~late endosome membrane,GO:0045121~membrane raft,GO:0048471~perinuclear region of cytoplasm,GO:0070062~extracellular exosome, GO:0001618~virus receptor activity,GO:0004872~receptor activity,GO:0004888~transmembrane signaling receptor activity,GO:0005319~lipid transporter activity,GO:0005515~protein binding,GO:0015248~sterol transporter activity,GO:0015485~cholesterol binding, IPR000731:Sterol-sensing domain,IPR003392:Patched,IPR004765:Niemann-Pick C type protein, hsa04142:Lysosome, 257220~Niemann-Pick disease, type C1,257220~Niemann-Pick disease, type D, 3D-structure,Alternative splicing,Cholesterol metabolism,Complete proteome,Disease mutation,Disulfide bond,Endosome,Glycoprotein,Host cell receptor for virus entry,Host-virus interaction,Lipid metabolism,Lysosome,Membrane,Niemann-Pick disease,Polymorphism,Proteomics identification,Receptor,Reference proteome,Signal,Steroid metabolism,Sterol metabolism,Transmembrane,Transmembrane helix, chain:Niemann-Pick C1 protein,compositionally biased region:Poly-Pro,domain:SSD,glycosylation site:N-linked (GlcNAc...),helix,mutagenesis site,sequence variant,short sequence motif:Di-leucine motif,signal peptide,strand,transmembrane region,turn, Q9VPW8 Pinocchio(Pino) Drosophila melanogaster GO:0007608~sensory perception of smell,GO:0042048~olfactory behavior,GO:2001020~regulation of response to DNA damage stimulus, Alternative splicing,Coiled coil,Complete proteome,Olfaction,Reference proteome,Sensory transduction, Q8TAQ2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2(SMARCC2) Homo sapiens h_hSWI-SNFpathway:Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes,h_vdrPathway:Control of Gene Expression by Vitamin D Receptor, Chromatin structure and dynamics / Transcription,General function prediction only, GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0006337~nucleosome disassembly,GO:0006338~chromatin remodeling,GO:0006351~transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0016569~covalent chromatin modification,GO:0021882~regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment,GO:0043044~ATP-dependent chromatin remodeling,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated, GO:0000790~nuclear chromatin,GO:0005654~nucleoplasm,GO:0016514~SWI/SNF complex,GO:0017053~transcriptional repressor complex,GO:0043234~protein complex,GO:0071564~npBAF complex,GO:0071565~nBAF complex,GO:0090544~BAF-type complex, GO:0000978~RNA polymerase II core promoter proximal region sequence-specific DNA binding,GO:0000980~RNA polymerase II distal enhancer sequence-specific DNA binding,GO:0003677~DNA binding,GO:0003682~chromatin binding,GO:0003713~transcription coactivator activity,GO:0005515~protein binding,GO:0031492~nucleosomal DNA binding, IPR000953:Chromo domain/shadow,IPR001005:SANT/Myb domain,IPR001357:BRCT domain,IPR007526:SWIRM domain,IPR009057:Homeodomain-like,IPR011991:Winged helix-turn-helix DNA-binding domain,IPR017884:SANT domain, SM00298:CHROMO,SM00717:SANT, Acetylation,Alternative splicing,Chromatin regulator,Coiled coil,Complete proteome,Isopeptide bond,Neurogenesis,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Transcription,Transcription regulation,Ubl conjugation, chain:SWI/SNF complex subunit SMARCC2,compositionally biased region:Glu-rich,compositionally biased region:Poly-Ala,compositionally biased region:Poly-Gln,compositionally biased region:Poly-Glu,compositionally biased region:Pro-rich,domain:SANT,domain:SWIRM,modified residue,sequence conflict,splice variant, Q00725 Salivary gland secretion 4(Sgs4) Drosophila melanogaster GO:0005576~extracellular region, Complete proteome,Polymorphism,Reference proteome,Repeat,Secreted,Signal, chain:Salivary glue protein Sgs-4,region of interest:22 X 7 AA approximate tandem repeats of T-[ETK]-[PT]-P-[RKT]-C-[ERK],repeat:1,repeat:10,repeat:11,repeat:12,repeat:13,repeat:14,repeat:15,repeat:16,repeat:17,repeat:18,repeat:19,repeat:2,repeat:20,repeat:21,repeat:22; approximate,repeat:3,repeat:4,repeat:5,repeat:6,repeat:7,repeat:8,repeat:9,sequence conflict,sequence variant,signal peptide, Q8SWR3 Sex peptide receptor(SPR) Drosophila melanogaster GO:0007186~G-protein coupled receptor signaling pathway,GO:0045434~negative regulation of female receptivity, post-mating,GO:0048042~regulation of post-mating oviposition, GO:0005886~plasma membrane,GO:0016021~integral component of membrane, GO:0008528~G-protein coupled peptide receptor activity, IPR000276:G protein-coupled receptor, rhodopsin-like,IPR017452:GPCR, rhodopsin-like, 7TM,IPR019427:7TM GPCR, serpentine receptor class w (Srw), Cell membrane,Complete proteome,G-protein coupled receptor,Membrane,Receptor,Reference proteome,Transducer,Transmembrane,Transmembrane helix, P17972 Shaker cognate w(Shaw) Drosophila melanogaster GO:0006813~potassium ion transport,GO:0030431~sleep,GO:0051260~protein homooligomerization,GO:0055085~transmembrane transport, GO:0005886~plasma membrane,GO:0008076~voltage-gated potassium channel complex, GO:0005249~voltage-gated potassium channel activity,GO:0005251~delayed rectifier potassium channel activity,GO:0022843~voltage-gated cation channel activity, IPR000210:BTB/POZ-like,IPR003131:Potassium channel tetramerisation-type BTB domain,IPR003968:Potassium channel, voltage dependent, Kv,IPR003974:Potassium channel, voltage dependent, Kv3,IPR005821:Ion transport domain,IPR011333:BTB/POZ fold,IPR015572:Voltage-dependent potassium channel Kv3, invertebrate,IPR027359:Voltage-dependent potassium channel, four helix bundle domain, SM00225:BTB, Complete proteome,Glycoprotein,Ion channel,Ion transport,Membrane,Potassium,Potassium channel,Potassium transport,Reference proteome,Transmembrane,Transmembrane helix,Transport,Voltage-gated channel, chain:Potassium voltage-gated channel protein Shaw,glycosylation site:N-linked (GlcNAc...),short sequence motif:Selectivity filter,transmembrane region, Q86DA5 Sterile alpha and TIR motif-containing protein tir-1(tir-1) Caenorhabditis elegans GO:0000003~reproduction,GO:0000187~activation of MAPK activity,GO:0002119~nematode larval development,GO:0002376~immune system process,GO:0006898~receptor-mediated endocytosis,GO:0006952~defense response,GO:0007165~signal transduction,GO:0007275~multicellular organism development,GO:0007399~nervous system development,GO:0007411~axon guidance,GO:0008104~protein localization,GO:0008340~determination of adult lifespan,GO:0009792~embryo development ending in birth or egg hatching,GO:0030154~cell differentiation,GO:0033554~cellular response to stress,GO:0040007~growth,GO:0042742~defense response to bacterium,GO:0045087~innate immune response,GO:0045168~cell-cell signaling involved in cell fate commitment,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0050832~defense response to fungus,GO:1902097~positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium, GO:0005737~cytoplasm,GO:1904115~axon cytoplasm, GO:0005515~protein binding,GO:0017137~Rab GTPase binding,GO:0019901~protein kinase binding,GO:0035591~signaling adaptor activity,GO:0042802~identical protein binding, IPR000157:Toll/interleukin-1 receptor homology (TIR) domain,IPR001660:Sterile alpha motif domain,IPR011989:Armadillo-like helical,IPR013761:Sterile alpha motif/pointed domain,IPR016024:Armadillo-type fold, SM00255:TIR,SM00454:SAM, Alternative splicing,Complete proteome,Cytoplasm,Developmental protein,Differentiation,Immunity,Innate immunity,Neurogenesis,Proteomics identification,Receptor,Reference proteome,Repeat, chain:Sterile alpha and TIR motif-containing protein tir-1,compositionally biased region:Pro-rich,domain:SAM 1,domain:SAM 2,domain:TIR,splice variant, O43734 TRAF3 interacting protein 2(TRAF3IP2) Homo sapiens GO:0001783~B cell apoptotic process,GO:0002230~positive regulation of defense response to virus by host,GO:0006959~humoral immune response,GO:0035556~intracellular signal transduction,GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling,GO:0048305~immunoglobulin secretion, GO:0005622~intracellular, GO:0005102~receptor binding,GO:0005515~protein binding, IPR013568:SEFIR, 614070~Psoriasis susceptibility 13,615527~Candidiasis, familial, 8, Alternative splicing,Complete proteome,Disease mutation,Polymorphism,Reference proteome, chain:Adapter protein CIKS,sequence conflict,sequence variant,splice variant, P70419 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3(Galnt3) Mus musculus Cell envelope biogenesis, outer membrane, GO:0018242~protein O-linked glycosylation via serine,GO:0018243~protein O-linked glycosylation via threonine, GO:0005794~Golgi apparatus,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0032580~Golgi cisterna membrane,GO:0048471~perinuclear region of cytoplasm,GO:0070062~extracellular exosome, GO:0004653~polypeptide N-acetylgalactosaminyltransferase activity,GO:0005509~calcium ion binding,GO:0016740~transferase activity,GO:0016757~transferase activity, transferring glycosyl groups,GO:0030145~manganese ion binding,GO:0030246~carbohydrate binding,GO:0046872~metal ion binding, IPR000772:Ricin B lectin domain,IPR001173:Glycosyl transferase, family 2, mmu00512:Mucin type O-Glycan biosynthesis,mmu01100:Metabolic pathways, SM00458:RICIN, Complete proteome,Disulfide bond,Glycoprotein,Glycosyltransferase,Golgi apparatus,Lectin,Manganese,Membrane,Metal-binding,Reference proteome,Signal-anchor,Transferase,Transmembrane,Transmembrane helix, chain:Polypeptide N- acetylgalactosaminyltransferase 3,disulfide bond,domain:Ricin B-type lectin,glycosylation site:N-linked (GlcNAc...),region of interest:Catalytic subdomain A,region of interest:Catalytic subdomain B,sequence conflict,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, Q6NH31 UvrABC system protein C(DIP_RS17745) Corynebacterium diphtheriae NCTC 13129 GO:0006289~nucleotide-excision repair,GO:0009432~SOS response, GO:0005737~cytoplasm,GO:0009380~excinuclease repair complex, GO:0003677~DNA binding,GO:0009381~excinuclease ABC activity, IPR000305:GIY-YIG nuclease superfamily,IPR001162:UvrC family homology region,IPR001943:UVR domain,IPR004791:UvrABC system, subunit C,IPR010994:RuvA domain 2-like,IPR027299:GIY-YIG domain, cdi03420:Nucleotide excision repair, SM00465:GIYc, Complete proteome,Cytoplasm,DNA damage,DNA excision,DNA repair,Excision nuclease,Reference proteome,SOS response, chain:UvrABC system protein C,domain:UVR, P27641 X-ray repair complementing defective repair in Chinese hamster cells 5(Xrcc5) Mus musculus m_telPathway:Telomeres, Telomerase, Cellular Aging, and Immortality, GO:0000237~leptotene,GO:0000723~telomere maintenance,GO:0006281~DNA repair,GO:0006302~double-strand break repair,GO:0006303~double-strand break repair via nonhomologous end joining,GO:0006310~DNA recombination,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006974~cellular response to DNA damage stimulus,GO:0007420~brain development,GO:0008283~cell proliferation,GO:0032508~DNA duplex unwinding,GO:0042493~response to drug,GO:0045892~negative regulation of transcription, DNA-templated,GO:0048660~regulation of smooth muscle cell proliferation,GO:0050769~positive regulation of neurogenesis,GO:0060218~hematopoietic stem cell differentiation,GO:0071398~cellular response to fatty acid,GO:0071475~cellular hyperosmotic salinity response,GO:0071480~cellular response to gamma radiation,GO:0071481~cellular response to X-ray,GO:1904430~negative regulation of t-circle formation, GO:0000784~nuclear chromosome, telomeric region,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005694~chromosome,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0043234~protein complex,GO:0043564~Ku70:Ku80 complex,GO:0070419~nonhomologous end joining complex, GO:0000166~nucleotide binding,GO:0003677~DNA binding,GO:0003684~damaged DNA binding,GO:0003690~double-stranded DNA binding,GO:0003691~double-stranded telomeric DNA binding,GO:0004003~ATP-dependent DNA helicase activity,GO:0004386~helicase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008022~protein C-terminus binding,GO:0016787~hydrolase activity,GO:0016817~hydrolase activity, acting on acid anhydrides,GO:0031625~ubiquitin protein ligase binding,GO:0042162~telomeric DNA binding,GO:0044212~transcription regulatory region DNA binding,GO:0044822~poly(A) RNA binding,GO:0044877~macromolecular complex binding,GO:0051575~5'-deoxyribose-5-phosphate lyase activity, IPR002035:von Willebrand factor, type A,IPR005160:Ku70/Ku80 C-terminal arm,IPR005161:Ku70/Ku80, N-terminal alpha/beta,IPR006164:Ku70/Ku80 beta-barrel domain,IPR014893:Ku, C-terminal,IPR016194:SPOC like C-terminal domain,IPR024193:Ku80, mmu03450:Non-homologous end-joining, PIRSF016570:Ku DNA-binding complex, Ku80 subunit [Parent=PIRSF800001], SM00559:Ku78, Acetylation,Activator,ATP-binding,Chromosome,Complete proteome,DNA damage,DNA recombination,DNA repair,DNA-binding,Helicase,Hydrolase,Isopeptide bond,Nucleotide-binding,Nucleus,Phosphoprotein,Reference proteome,Signal,Transcription,Transcription regulation,Ubl conjugation, chain:ATP-dependent DNA helicase 2 subunit 2,compositionally biased region:Pro-rich,domain:Ku,domain:Leucine-zipper,modified residue,sequence conflict,short sequence motif:EEXXXDL motif, Q91ZS8 adenosine deaminase, RNA-specific, B1(Adarb1) Mus musculus GO:0006382~adenosine to inosine editing,GO:0006396~RNA processing,GO:0006397~mRNA processing,GO:0008285~negative regulation of cell proliferation,GO:0016553~base conversion or substitution editing,GO:0016556~mRNA modification,GO:0030336~negative regulation of cell migration,GO:0044387~negative regulation of protein kinase activity by regulation of protein phosphorylation,GO:0045070~positive regulation of viral genome replication,GO:0050685~positive regulation of mRNA processing,GO:0051726~regulation of cell cycle, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0016021~integral component of membrane, GO:0003723~RNA binding,GO:0003725~double-stranded RNA binding,GO:0003726~double-stranded RNA adenosine deaminase activity,GO:0004000~adenosine deaminase activity,GO:0016787~hydrolase activity,GO:0042803~protein homodimerization activity,GO:0044822~poly(A) RNA binding,GO:0046872~metal ion binding, IPR002466:Adenosine deaminase/editase,IPR014720:Double-stranded RNA-binding-like domain, SM00358:DSRM,SM00552:ADEAMc, 3D-structure,Alternative splicing,Complete proteome,Hydrolase,Membrane,Metal-binding,mRNA processing,Nucleus,Phosphoprotein,Reference proteome,Repeat,RNA-binding,Transmembrane,Transmembrane helix,Zinc, active site:Proton donor,binding site:Inositol hexakisphosphate,chain:Double-stranded RNA-specific editase 1,domain:A to I editase,domain:DRBM 1,domain:DRBM 2,metal ion-binding site:Zinc,sequence conflict,splice variant, Q5CZR5 aerolysin-like protein(aep1) Danio rerio GO:0051260~protein homooligomerization, GO:0046930~pore complex, GO:0005537~mannose binding,GO:0030246~carbohydrate binding,GO:0042803~protein homodimerization activity,GO:0048030~disaccharide binding, IPR001229:Mannose-binding lectin,IPR004991:Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2,IPR023307:Aerolysin-like toxin, beta complex domain, 3D-structure,Complete proteome,Lectin,Reference proteome, chain:Natterin-like protein, P34109 class I myosin(myoD) Dictyostelium discoideum AX4 GO:0006909~phagocytosis,GO:0006935~chemotaxis, GO:0005737~cytoplasm,GO:0005938~cell cortex,GO:0016459~myosin complex,GO:0031143~pseudopodium,GO:0031252~cell leading edge,GO:0042995~cell projection, GO:0000166~nucleotide binding,GO:0003774~motor activity,GO:0003779~actin binding,GO:0005524~ATP binding, IPR001452:Src homology-3 domain,IPR001609:Myosin head, motor domain,IPR010926:Myosin tail 2,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00242:MYSc,SM00326:SH3, Actin-binding,ATP-binding,Cell projection,Chemotaxis,Complete proteome,Cytoplasm,Direct protein sequencing,Motor protein,Myosin,Nucleotide-binding,Phagocytosis,Reference proteome,SH3 domain, P53621 coatomer protein complex subunit alpha(COPA) Homo sapiens h_arapPathway:ADP-Ribosylation Factor, GO:0006886~intracellular protein transport,GO:0006888~ER to Golgi vesicle-mediated transport,GO:0006890~retrograde vesicle-mediated transport, Golgi to ER,GO:0006891~intra-Golgi vesicle-mediated transport,GO:0030157~pancreatic juice secretion, GO:0000139~Golgi membrane,GO:0005615~extracellular space,GO:0005737~cytoplasm,GO:0005789~endoplasmic reticulum membrane,GO:0005829~cytosol,GO:0016020~membrane,GO:0030126~COPI vesicle coat,GO:0030133~transport vesicle,GO:0070062~extracellular exosome, GO:0005179~hormone activity,GO:0005198~structural molecule activity, IPR001680:WD40 repeat,IPR006692:Coatomer, WD associated region,IPR010714:Coatomer, alpha subunit, C-terminal,IPR011048:Cytochrome cd1-nitrite reductase-like, C-terminal haem d1,IPR015943:WD40/YVTN repeat-like-containing domain,IPR016391:Coatomer alpha subunit,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site,IPR020472:G-protein beta WD-40 repeat,IPR024977:Anaphase-promoting complex subunit 4, WD40 domain, 616414~Autoimmune interstitial lung, joint, and kidney disease, PIRSF003354:coatomer, alpha subunit, SM00320:WD40, Alternative splicing,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Direct protein sequencing,Disease mutation,ER-Golgi transport,Golgi apparatus,Hormone,Membrane,Methylation,Phosphoprotein,Polymorphism,Protein transport,Reference proteome,Repeat,RNA editing,Secreted,Transport,WD repeat, chain:Coatomer subunit alpha,modified residue,peptide:Proxenin,peptide:Xenin,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,sequence conflict,sequence variant,splice variant, P35604 coatomer protein complex subunit zeta 1(COPZ1) Bos taurus GO:0006886~intracellular protein transport,GO:0006890~retrograde vesicle-mediated transport, Golgi to ER,GO:0006891~intra-Golgi vesicle-mediated transport,GO:1901998~toxin transport, GO:0000139~Golgi membrane,GO:0030126~COPI vesicle coat, IPR000804:Clathrin adaptor complex, small chain,IPR011012:Longin-like domain,IPR022775:AP complex, mu/sigma subunit, 3D-structure,Acetylation,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Direct protein sequencing,ER-Golgi transport,Golgi apparatus,Membrane,Protein transport,Reference proteome,Transport, chain:Coatomer subunit zeta-1,modified residue,sequence conflict, O42163 cochlin(COCH) Gallus gallus GO:0007605~sensory perception of sound,GO:0008360~regulation of cell shape,GO:0042742~defense response to bacterium,GO:0045089~positive regulation of innate immune response, GO:0005578~proteinaceous extracellular matrix,GO:0031012~extracellular matrix,GO:0070062~extracellular exosome, GO:0005518~collagen binding, IPR002035:von Willebrand factor, type A,IPR004043:LCCL, SM00327:VWA,SM00603:LCCL, Complete proteome,Disulfide bond,Glycoprotein,Reference proteome,Repeat,Secreted,Signal, chain:Cochlin,disulfide bond,domain:LCCL,domain:VWFA 1,domain:VWFA 2,glycosylation site:N-linked (GlcNAc...),signal peptide, Q9DCB4 cyclic AMP-regulated phosphoprotein, 21(Arpp21) Mus musculus GO:0034605~cellular response to heat, GO:0005737~cytoplasm, GO:0003676~nucleic acid binding,GO:0005516~calmodulin binding, IPR001374:Single-stranded nucleic acid binding R3H,IPR024771:SUZ domain, SM00393:R3H, Acetylation,Alternative splicing,Calmodulin-binding,Coiled coil,Complete proteome,Cytoplasm,Direct protein sequencing,Methylation,Phosphoprotein,Proteomics identification,Reference proteome, chain:cAMP-regulated phosphoprotein 21,compositionally biased region:Gln-rich,compositionally biased region:Ser-rich,domain:R3H,modified residue,mutagenesis site,sequence conflict,splice variant, Q2QLH0 cystic fibrosis transmembrane conductance regulator(CFTR) Otolemur garnettii GO:0006695~cholesterol biosynthetic process,GO:0006904~vesicle docking involved in exocytosis,GO:0030301~cholesterol transport,GO:0035774~positive regulation of insulin secretion involved in cellular response to glucose stimulus,GO:0045921~positive regulation of exocytosis,GO:0048240~sperm capacitation,GO:0051454~intracellular pH elevation,GO:0060081~membrane hyperpolarization,GO:0071320~cellular response to cAMP,GO:1902161~positive regulation of cyclic nucleotide-gated ion channel activity,GO:1902943~positive regulation of voltage-gated chloride channel activity, GO:0005769~early endosome,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0009986~cell surface,GO:0016324~apical plasma membrane,GO:0031205~endoplasmic reticulum Sec complex,GO:0031901~early endosome membrane,GO:0034707~chloride channel complex,GO:0055037~recycling endosome,GO:0070062~extracellular exosome, GO:0005254~chloride channel activity,GO:0005260~channel-conductance-controlling ATPase activity,GO:0005524~ATP binding,GO:0015106~bicarbonate transmembrane transporter activity,GO:0015108~chloride transmembrane transporter activity,GO:0019869~chloride channel inhibitor activity, IPR003439:ABC transporter-like,IPR003593:AAA+ ATPase domain,IPR009147:Cystic fibrosis transmembrane conductance regulator,IPR011527:ABC transporter, transmembrane domain, type 1,IPR017871:ABC transporter, conserved site,IPR025837:CFTR regulator domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00382:AAA, ATP-binding,Cell membrane,Chloride,Chloride channel,Complete proteome,Endosome,Glycoprotein,Hydrolase,Ion channel,Ion transport,Isopeptide bond,Lipoprotein,Membrane,Nucleotide-binding,Palmitate,Phosphoprotein,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Transport,Ubl conjugation, Q5BJ68 cytochrome b5 reductase 2(cyb5r2) Xenopus tropicalis GO:0001878~response to yeast,GO:0016126~sterol biosynthetic process, GO:0005739~mitochondrion,GO:0016021~integral component of membrane, GO:0004128~cytochrome-b5 reductase activity, acting on NAD(P)H,GO:0071949~FAD binding, IPR001433:Oxidoreductase FAD/NAD(P)-binding,IPR001709:Flavoprotein pyridine nucleotide cytochrome reductase,IPR001834:NADH:cytochrome b5 reductase (CBR),IPR008333:Oxidoreductase, FAD-binding domain,IPR017927:Ferredoxin reductase-type FAD-binding domain,IPR017938:Riboflavin synthase-like beta-barrel, xtr00520:Amino sugar and nucleotide sugar metabolism, Complete proteome,FAD,Flavoprotein,Lipid biosynthesis,Lipid metabolism,Membrane,NAD,Oxidoreductase,Reference proteome,Steroid biosynthesis,Steroid metabolism,Sterol biosynthesis,Sterol metabolism,Transmembrane,Transmembrane helix, chain:NADH-cytochrome b5 reductase 2,domain:FAD-binding FR-type,nucleotide phosphate-binding region:FAD,transmembrane region, Q8BI55 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4(Dyrk4) Mus musculus GO:0006468~protein phosphorylation,GO:0016310~phosphorylation, GO:0005737~cytoplasm,GO:0043231~intracellular membrane-bounded organelle, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0004712~protein serine/threonine/tyrosine kinase activity,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0016740~transferase activity,GO:0046872~metal ion binding, IPR000719:Protein kinase, catalytic domain,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, SM00220:S_TKc, Alternative splicing,ATP-binding,Complete proteome,Cytoplasm,Kinase,Magnesium,Metal-binding,Nucleotide-binding,Phosphoprotein,Reference proteome,Serine/threonine-protein kinase,Transferase, active site:Proton acceptor,binding site:ATP,chain:Dual specificity tyrosine- phosphorylation-regulated kinase 4,domain:Protein kinase,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,splice variant, Q566Y1 elongator acetyltransferase complex subunit 4(elp4) Danio rerio GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0006368~transcription elongation from RNA polymerase II promoter,GO:0043966~histone H3 acetylation,GO:0043967~histone H4 acetylation, GO:0000123~histone acetyltransferase complex,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0008023~transcription elongation factor complex,GO:0033588~Elongator holoenzyme complex, GO:0000993~RNA polymerase II core binding,GO:0004402~histone acetyltransferase activity,GO:0008607~phosphorylase kinase regulator activity, IPR008728:Elongator complex protein 4,IPR027417:P-loop containing nucleoside triphosphate hydrolase, Complete proteome,Nucleus,Proteomics identification,Reference proteome,Transcription,Transcription regulation, chain:Elongator complex protein 4,sequence conflict, P78344 eukaryotic translation initiation factor 4 gamma 2(EIF4G2) Homo sapiens h_eif4Pathway:Regulation of eIF4e and p70 S6 Kinase,h_eifPathway:Eukaryotic protein translation,h_iresPathway:Internal Ribosome entry pathway,h_mtorPathway:mTOR Signaling Pathway, GO:0006413~translational initiation,GO:0006446~regulation of translational initiation,GO:0007050~cell cycle arrest,GO:0007507~heart development,GO:0008219~cell death,GO:0010507~negative regulation of autophagy,GO:0030307~positive regulation of cell growth,GO:0034645~cellular macromolecule biosynthetic process,GO:0045727~positive regulation of translation,GO:0045773~positive regulation of axon extension,GO:0060999~positive regulation of dendritic spine development,GO:0098609~cell-cell adhesion, GO:0005829~cytosol,GO:0005913~cell-cell adherens junction,GO:0016020~membrane,GO:0016281~eukaryotic translation initiation factor 4F complex,GO:0030424~axon, GO:0003723~RNA binding,GO:0003743~translation initiation factor activity,GO:0005515~protein binding,GO:0008135~translation factor activity, RNA binding,GO:0044822~poly(A) RNA binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR003307:W2 domain,IPR003890:MIF4G-like, type 3,IPR003891:Initiation factor eIF-4 gamma, MA3,IPR016021:MIF4-like, type 1/2/3,IPR016024:Armadillo-type fold, hsa03013:RNA transport,hsa05416:Viral myocarditis, SM00515:eIF5C,SM00543:MIF4G,SM00544:MA3, 3D-structure,Acetylation,Alternative splicing,Complete proteome,Direct protein sequencing,Initiation factor,Methylation,Phosphoprotein,Polymorphism,Protein biosynthesis,Proteomics identification,Reference proteome,Repressor,Translation regulation, chain:Eukaryotic translation initiation factor 4 gamma 2,domain:MI,domain:MIF4G,domain:W2,helix,modified residue,sequence conflict,sequence variant,splice variant, P35916 fms related tyrosine kinase 4(FLT4) Homo sapiens h_no1Pathway:Actions of Nitric Oxide in the Heart,h_vegfPathway:VEGF, Hypoxia, and Angiogenesis, GO:0001934~positive regulation of protein phosphorylation,GO:0001938~positive regulation of endothelial cell proliferation,GO:0001944~vasculature development,GO:0001945~lymph vessel development,GO:0001946~lymphangiogenesis,GO:0002040~sprouting angiogenesis,GO:0003016~respiratory system process,GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway,GO:0008284~positive regulation of cell proliferation,GO:0010575~positive regulation of vascular endothelial growth factor production,GO:0010595~positive regulation of endothelial cell migration,GO:0018108~peptidyl-tyrosine phosphorylation,GO:0035924~cellular response to vascular endothelial growth factor stimulus,GO:0038084~vascular endothelial growth factor signaling pathway,GO:0043066~negative regulation of apoptotic process,GO:0043410~positive regulation of MAPK cascade,GO:0046330~positive regulation of JNK cascade,GO:0046777~protein autophosphorylation,GO:0048010~vascular endothelial growth factor receptor signaling pathway,GO:0048286~lung alveolus development,GO:0048514~blood vessel morphogenesis,GO:0060312~regulation of blood vessel remodeling,GO:0070374~positive regulation of ERK1 and ERK2 cascade,GO:0090037~positive regulation of protein kinase C signaling, GO:0005576~extracellular region,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0043235~receptor complex, GO:0004714~transmembrane receptor protein tyrosine kinase activity,GO:0005021~vascular endothelial growth factor-activated receptor activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0019838~growth factor binding,GO:0019903~protein phosphatase binding, IPR000719:Protein kinase, catalytic domain,IPR001245:Serine-threonine/tyrosine-protein kinase catalytic domain,IPR001824:Tyrosine-protein kinase, receptor class III, conserved site,IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR007110:Immunoglobulin-like domain,IPR008266:Tyrosine-protein kinase, active site,IPR009137:Tyrosine-protein kinase, vascular endothelial growth factor receptor 3 (VEGFR3), N-terminal,IPR011009:Protein kinase-like domain,IPR013098:Immunoglobulin I-set,IPR013783:Immunoglobulin-like fold,IPR017441:Protein kinase, ATP binding site,IPR020635:Tyrosine-protein kinase, catalytic domain, hsa04014:Ras signaling pathway,hsa04015:Rap1 signaling pathway,hsa04151:PI3K-Akt signaling pathway,hsa04510:Focal adhesion, 153100~Lymphedema, hereditary, IA,602089~Hemangioma, capillary infantile, somatic, SM00219:TyrKc,SM00408:IGc2,SM00409:IG, 3D-structure,Alternative splicing,Angiogenesis,ATP-binding,Cell membrane,Complete proteome,Cytoplasm,Direct protein sequencing,Disease mutation,Disulfide bond,Glycoprotein,Immunoglobulin domain,Kinase,Membrane,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Receptor,Reference proteome,Repeat,Secreted,Signal,Transferase,Transmembrane,Transmembrane helix,Tyrosine-protein kinase, active site:Proton acceptor,binding site:ATP,chain:Vascular endothelial growth factor receptor 3,disulfide bond,domain:Ig-like C2-type 1,domain:Ig-like C2-type 2,domain:Ig-like C2-type 3,domain:Ig-like C2-type 4,domain:Ig-like C2-type 5,domain:Ig-like C2-type 6,domain:Ig-like C2-type 7,domain:Protein kinase,glycosylation site:N-linked (GlcNAc...),modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,sequence variant,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, P20735 gamma-glutamyltransferase 1(GGT1) Sus scrofa GO:0002682~regulation of immune system process,GO:0006536~glutamate metabolic process,GO:0006749~glutathione metabolic process,GO:0006750~glutathione biosynthetic process,GO:0006751~glutathione catabolic process,GO:0007283~spermatogenesis,GO:0019344~cysteine biosynthetic process,GO:0031638~zymogen activation,GO:0050727~regulation of inflammatory response, GO:0005886~plasma membrane,GO:0016021~integral component of membrane,GO:0031988~membrane-bounded vesicle, GO:0003840~gamma-glutamyltransferase activity,GO:0036374~glutathione hydrolase activity, IPR000101:Gamma-glutamyltranspeptidase, ssc00430:Taurine and hypotaurine metabolism,ssc00460:Cyanoamino acid metabolism,ssc00480:Glutathione metabolism,ssc00590:Arachidonic acid metabolism,ssc01100:Metabolic pathways, Acyltransferase,Cell membrane,Complete proteome,Disulfide bond,Glutathione biosynthesis,Glycoprotein,Hydrolase,Membrane,Protease,Proteomics identification,Reference proteome,Signal-anchor,Transferase,Transmembrane,Transmembrane helix,Zymogen, chain:Gamma-glutamyltranspeptidase 1 heavy chain,chain:Gamma-glutamyltranspeptidase 1 light chain,glycosylation site:N-linked (GlcNAc...),topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q13002 glutamate ionotropic receptor kainate type subunit 2(GRIK2) Homo sapiens GO:0001662~behavioral fear response,GO:0006810~transport,GO:0006874~cellular calcium ion homeostasis,GO:0006886~intracellular protein transport,GO:0007215~glutamate receptor signaling pathway,GO:0007268~chemical synaptic transmission,GO:0019228~neuronal action potential,GO:0034220~ion transmembrane transport,GO:0035235~ionotropic glutamate receptor signaling pathway,GO:0035249~synaptic transmission, glutamatergic,GO:0043113~receptor clustering,GO:0043524~negative regulation of neuron apoptotic process,GO:0043525~positive regulation of neuron apoptotic process,GO:0046328~regulation of JNK cascade,GO:0048169~regulation of long-term neuronal synaptic plasticity,GO:0048172~regulation of short-term neuronal synaptic plasticity,GO:0050804~modulation of synaptic transmission,GO:0050806~positive regulation of synaptic transmission,GO:0051402~neuron apoptotic process,GO:0051967~negative regulation of synaptic transmission, glutamatergic,GO:0060079~excitatory postsynaptic potential,GO:0060080~inhibitory postsynaptic potential, GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0014069~postsynaptic density,GO:0016021~integral component of membrane,GO:0030054~cell junction,GO:0032839~dendrite cytoplasm,GO:0032983~kainate selective glutamate receptor complex,GO:0042734~presynaptic membrane,GO:0043195~terminal bouton,GO:0043204~perikaryon,GO:0045211~postsynaptic membrane, GO:0004970~ionotropic glutamate receptor activity,GO:0005234~extracellular-glutamate-gated ion channel activity,GO:0015276~ligand-gated ion channel activity,GO:0015277~kainate selective glutamate receptor activity,GO:0030165~PDZ domain binding,GO:0031624~ubiquitin conjugating enzyme binding,GO:0031625~ubiquitin protein ligase binding,GO:0042803~protein homodimerization activity, IPR001320:Ionotropic glutamate receptor,IPR001508:NMDA receptor,IPR001828:Extracellular ligand-binding receptor,IPR019594:Glutamate receptor, L-glutamate/glycine-binding, hsa04080:Neuroactive ligand-receptor interaction,hsa04724:Glutamatergic synapse, 611092~Mental retardation, autosomal recessive, 6, SM00079:PBPe,SM00918:SM00918, 3D-structure,Alternative splicing,Cell junction,Cell membrane,Complete proteome,Disulfide bond,Glycoprotein,Ion channel,Ion transport,Isopeptide bond,Ligand-gated ion channel,Membrane,Mental retardation,Phosphoprotein,Polymorphism,Postsynaptic cell membrane,Proteomics identification,Receptor,Reference proteome,RNA editing,Signal,Synapse,Transmembrane,Transmembrane helix,Transport,Ubl conjugation, binding site:Glutamate,chain:Glutamate receptor, ionotropic kainate 2,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO-1),glycosylation site:N-linked (GlcNAc...),region of interest:Glutamate binding,sequence conflict,sequence variant,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q38PU2 glutamate ionotropic receptor kainate type subunit 3(GRIK3) Macaca fascicularis GO:0007216~G-protein coupled glutamate receptor signaling pathway, GO:0016021~integral component of membrane,GO:0030054~cell junction,GO:0043197~dendritic spine,GO:0045211~postsynaptic membrane, GO:0001640~adenylate cyclase inhibiting G-protein coupled glutamate receptor activity,GO:0004970~ionotropic glutamate receptor activity,GO:0005234~extracellular-glutamate-gated ion channel activity, IPR001320:Ionotropic glutamate receptor,IPR001508:NMDA receptor,IPR001828:Extracellular ligand-binding receptor,IPR019594:Glutamate receptor, L-glutamate/glycine-binding, mcf04080:Neuroactive ligand-receptor interaction,mcf04724:Glutamatergic synapse, SM00079:PBPe,SM00918:SM00918, Cell junction,Cell membrane,Disulfide bond,Glycoprotein,Ion channel,Ion transport,Isopeptide bond,Ligand-gated ion channel,Membrane,Phosphoprotein,Postsynaptic cell membrane,Receptor,Signal,Synapse,Transmembrane,Transmembrane helix,Transport,Ubl conjugation, Q17QR8 harbinger transposase derived 1(HARBI1) Bos taurus GO:0090305~nucleic acid phosphodiester bond hydrolysis, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005813~centrosome, GO:0004518~nuclease activity,GO:0046872~metal ion binding, IPR026103:Harbinger transposase-derived nuclease, Complete proteome,Cytoplasm,Hydrolase,Metal-binding,Nuclease,Nucleus,Reference proteome, chain:Putative nuclease HARBI1,metal ion-binding site:Divalent metal cation, Q8BR93 harbinger transposase derived 1(Harbi1) Mus musculus GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005813~centrosome, GO:0004518~nuclease activity,GO:0016787~hydrolase activity,GO:0046872~metal ion binding, IPR026103:Harbinger transposase-derived nuclease, Alternative splicing,Complete proteome,Cytoplasm,Hydrolase,Metal-binding,Nuclease,Nucleus,Reference proteome, chain:Putative nuclease HARBI1,metal ion-binding site:Divalent metal cation,sequence conflict,splice variant, Q08821 homeobox A1 S homeolog(hoxa1.S) Xenopus laevis GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007275~multicellular organism development, GO:0005634~nucleus, GO:0043565~sequence-specific DNA binding, IPR001356:Homeodomain,IPR009057:Homeodomain-like,IPR017970:Homeobox, conserved site,IPR020479:Homeodomain, metazoa, SM00389:HOX, Developmental protein,DNA-binding,Homeobox,Nucleus,Transcription,Transcription regulation, chain:Homeobox protein Hox-A1,DNA-binding region:Homeobox,short sequence motif:Antp-type hexapeptide, Q1KL12 homeobox A3(hoxa3) Takifugu rubripes GO:0006351~transcription, DNA-templated,GO:0007275~multicellular organism development, GO:0005634~nucleus, GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0043565~sequence-specific DNA binding, IPR001356:Homeodomain,IPR001827:Homeobox protein, antennapedia type, conserved site,IPR009057:Homeodomain-like,IPR017970:Homeobox, conserved site,IPR020479:Homeodomain, metazoa,IPR025281:Domain of unknown function DUF4074, SM00389:HOX, Complete proteome,Developmental protein,DNA-binding,Homeobox,Nucleus,Reference proteome,Transcription,Transcription regulation, Q9TT89 homeobox B7(HOXB7) Bos taurus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007275~multicellular organism development,GO:0009952~anterior/posterior pattern specification,GO:0030099~myeloid cell differentiation,GO:0048704~embryonic skeletal system morphogenesis,GO:0090190~positive regulation of branching involved in ureteric bud morphogenesis, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm, GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0043565~sequence-specific DNA binding, IPR001356:Homeodomain,IPR001827:Homeobox protein, antennapedia type, conserved site,IPR009057:Homeodomain-like,IPR017970:Homeobox, conserved site,IPR017995:Homeobox protein, antennapedia type,IPR020479:Homeodomain, metazoa, SM00389:HOX, Complete proteome,Developmental protein,DNA-binding,Homeobox,Isopeptide bond,Nucleus,Reference proteome,Transcription,Transcription regulation, chain:Homeobox protein Hox-B7,compositionally biased region:Glu-rich (acidic),cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),DNA-binding region:Homeobox,short sequence motif:Antp-type hexapeptide, O43248 homeobox C11(HOXC11) Homo sapiens GO:0001656~metanephros development,GO:0001759~organ induction,GO:0006366~transcription from RNA polymerase II promoter,GO:0007492~endoderm development,GO:0009952~anterior/posterior pattern specification,GO:0009954~proximal/distal pattern formation,GO:0042733~embryonic digit morphogenesis,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0060272~embryonic skeletal joint morphogenesis, GO:0005654~nucleoplasm,GO:0005737~cytoplasm, GO:0000978~RNA polymerase II core promoter proximal region sequence-specific DNA binding,GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding, IPR001356:Homeodomain,IPR009057:Homeodomain-like,IPR017970:Homeobox, conserved site,IPR020479:Homeodomain, metazoa,IPR021918:Domain of unknown function DUF3528, homeobox protein, eukaryotic, SM00389:HOX, Complete proteome,Developmental protein,DNA-binding,Homeobox,Isopeptide bond,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Transcription,Transcription regulation,Ubl conjugation, chain:Homeobox protein Hox-C11,DNA-binding region:Homeobox,sequence conflict,sequence variant, Q1KKS8 homeobox D4(hoxd4) Takifugu rubripes GO:0006351~transcription, DNA-templated,GO:0007275~multicellular organism development, GO:0005634~nucleus, GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding, IPR001356:Homeodomain,IPR001827:Homeobox protein, antennapedia type, conserved site,IPR009057:Homeodomain-like,IPR017995:Homeobox protein, antennapedia type,IPR020479:Homeodomain, metazoa, SM00389:HOX, Complete proteome,Developmental protein,DNA-binding,Homeobox,Nucleus,Reference proteome,Transcription,Transcription regulation, P34456 hypothetical protein(F54H12.2) Caenorhabditis elegans GO:0009263~deoxyribonucleotide biosynthetic process,GO:0055114~oxidation-reduction process, GO:0005829~cytosol,GO:0005971~ribonucleoside-diphosphate reductase complex, GO:0004748~ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor, Complete proteome,Reference proteome, chain:Uncharacterized protein F54H12.2, P02599 hypothetical protein(calA) Dictyostelium discoideum AX4 GO:0000281~mitotic cytokinesis,GO:0007049~cell cycle,GO:0032781~positive regulation of ATPase activity,GO:0043549~regulation of kinase activity,GO:0045861~negative regulation of proteolysis,GO:0051301~cell division,GO:0051343~positive regulation of cyclic-nucleotide phosphodiesterase activity,GO:0061122~positive regulation of positive chemotaxis to cAMP,GO:0072666~establishment of protein localization to vacuole,GO:1903665~negative regulation of asexual reproduction, GO:0000331~contractile vacuole,GO:0005615~extracellular space,GO:0005622~intracellular,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005773~vacuole,GO:0031012~extracellular matrix, GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0019900~kinase binding,GO:0019901~protein kinase binding,GO:0031013~troponin I binding,GO:0046872~metal ion binding,GO:0050839~cell adhesion molecule binding, IPR002048:EF-hand domain,IPR011992:EF-hand-like domain,IPR018247:EF-Hand 1, calcium-binding site, ddi04070:Phosphatidylinositol signaling system, SM00054:EFh, Acetylation,Calcium,Cell cycle,Cell division,Complete proteome,Direct protein sequencing,Metal-binding,Reference proteome,Repeat,Vacuole, O35015 hypothetical protein(yngK) Bacillus subtilis subsp. subtilis str. 168 Function unknown, GO:0030288~outer membrane-bounded periplasmic space, IPR003790:Protein of unknown function DUF187,IPR013783:Immunoglobulin-like fold,IPR017853:Glycoside hydrolase, superfamily, Complete proteome,Reference proteome,Signal, chain:UPF0748 protein yngK,signal peptide, Q53G44 interferon induced protein 44 like(IFI44L) Homo sapiens Cell division and chromosome partitioning / Cytoskeleton, GO:0051607~defense response to virus, GO:0005654~nucleoplasm,GO:0005737~cytoplasm, GO:0005525~GTP binding, IPR006073:GTP binding domain,IPR024644:Interferon-induced protein 44 family,IPR027417:P-loop containing nucleoside triphosphate hydrolase, Alternative splicing,Antiviral defense,Complete proteome,Cytoplasm,Polymorphism,Proteomics identification,Reference proteome, chain:Interferon-induced protein 44-like,sequence conflict,sequence variant,splice variant, Q8CI17 mab-21-like 3 (C. elegans)(Mab21l3) Mus musculus IPR024810:Mab-21 domain, SM01265:SM01265, Complete proteome,Reference proteome, chain:Uncharacterized protein C1orf161 homolog,sequence conflict, P39021 mesenchyme homeobox 2 L homeolog(meox2.L) Xenopus laevis GO:0006351~transcription, DNA-templated,GO:0007275~multicellular organism development, GO:0005634~nucleus,GO:0016607~nuclear speck, GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0043565~sequence-specific DNA binding, IPR001356:Homeodomain,IPR009057:Homeodomain-like,IPR017970:Homeobox, conserved site,IPR020479:Homeodomain, metazoa, SM00389:HOX, Activator,Developmental protein,DNA-binding,Homeobox,Nucleus,Transcription,Transcription regulation, A5PF48 myosin Ic, paralog a(myo1ca) Danio rerio GO:0032835~glomerulus development, GO:0001726~ruffle,GO:0016023~cytoplasmic, membrane-bounded vesicle,GO:0016459~myosin complex,GO:0060171~stereocilium membrane, GO:0000166~nucleotide binding,GO:0003774~motor activity,GO:0003779~actin binding,GO:0005524~ATP binding, IPR000048:IQ motif, EF-hand binding site,IPR001609:Myosin head, motor domain,IPR010926:Myosin tail 2,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00015:IQ,SM00242:MYSc, Acetylation,Actin-binding,ATP-binding,Cell membrane,Cell projection,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Membrane,Methylation,Motor protein,Myosin,Nucleotide-binding,Reference proteome,Repeat, chain:Myosin-Ic,domain:IQ 1,domain:IQ 2,domain:Myosin head-like,modified residue,nucleotide phosphate-binding region:ATP, Q94K49 nuclease(AT3G63270) Arabidopsis thaliana GO:0031936~negative regulation of chromatin silencing, GO:0005634~nucleus, GO:0003682~chromatin binding,GO:0005515~protein binding, Complete proteome,Reference proteome, Q8CI95 oxysterol binding protein-like 11(Osbpl11) Mus musculus GO:0006810~transport,GO:0006869~lipid transport,GO:0010890~positive regulation of sequestering of triglyceride,GO:0045444~fat cell differentiation, GO:0005768~endosome,GO:0005794~Golgi apparatus,GO:0016020~membrane,GO:0031902~late endosome membrane, GO:0008289~lipid binding, IPR000648:Oxysterol-binding protein,IPR001849:Pleckstrin homology domain,IPR011993:Pleckstrin homology-like domain,IPR018494:Oxysterol-binding protein, conserved site, SM00233:PH, Acetylation,Complete proteome,Endosome,Golgi apparatus,Lipid transport,Lipid-binding,Membrane,Phosphoprotein,Proteomics identification,Reference proteome,Transport, chain:Oxysterol-binding protein-related protein 11,domain:PH,modified residue, Q9UBV8 penta-EF-hand domain containing 1(PEF1) Homo sapiens Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only, GO:0006508~proteolysis,GO:0051592~response to calcium ion, GO:0005737~cytoplasm,GO:0016020~membrane,GO:0070062~extracellular exosome, GO:0004198~calcium-dependent cysteine-type endopeptidase activity,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0044822~poly(A) RNA binding,GO:0046982~protein heterodimerization activity,GO:0046983~protein dimerization activity, IPR002048:EF-hand domain,IPR011992:EF-hand-like domain,IPR018247:EF-Hand 1, calcium-binding site, SM00054:EFh, Calcium,Complete proteome,Cytoplasm,Membrane,Metal-binding,Reference proteome,Repeat, calcium-binding region:1,calcium-binding region:2,chain:Peflin,domain:EF-hand 1,domain:EF-hand 2,domain:EF-hand 3,domain:EF-hand 4,domain:EF-hand 5,region of interest:9 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-P,region of interest:Required for interaction with PDCD6/ALG2,repeat:1,repeat:2,repeat:3,repeat:4,repeat:5,repeat:6,repeat:7,repeat:8,repeat:9, Q03181 peroxisome proliferator activated receptor delta(PPARD) Homo sapiens h_nuclearRsPathway:Nuclear Receptors in Lipid Metabolism and Toxicity,h_pparPathway:Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression,h_wntPathway:WNT Signaling Pathway, GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0006006~glucose metabolic process,GO:0006029~proteoglycan metabolic process,GO:0006091~generation of precursor metabolites and energy,GO:0006351~transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0006367~transcription initiation from RNA polymerase II promoter,GO:0006629~lipid metabolic process,GO:0006635~fatty acid beta-oxidation,GO:0006776~vitamin A metabolic process,GO:0006915~apoptotic process,GO:0007507~heart development,GO:0007566~embryo implantation,GO:0008203~cholesterol metabolic process,GO:0008283~cell proliferation,GO:0008366~axon ensheathment,GO:0008654~phospholipid biosynthetic process,GO:0009062~fatty acid catabolic process,GO:0009299~mRNA transcription,GO:0009749~response to glucose,GO:0010628~positive regulation of gene expression,GO:0014068~positive regulation of phosphatidylinositol 3-kinase signaling,GO:0014823~response to activity,GO:0014842~regulation of skeletal muscle satellite cell proliferation,GO:0014912~negative regulation of smooth muscle cell migration,GO:0015758~glucose transport,GO:0015908~fatty acid transport,GO:0030154~cell differentiation,GO:0030308~negative regulation of cell growth,GO:0030522~intracellular receptor signaling pathway,GO:0031589~cell-substrate adhesion,GO:0032024~positive regulation of insulin secretion,GO:0032966~negative regulation of collagen biosynthetic process,GO:0033189~response to vitamin A,GO:0042060~wound healing,GO:0043066~negative regulation of apoptotic process,GO:0043401~steroid hormone mediated signaling pathway,GO:0043415~positive regulation of skeletal muscle tissue regeneration,GO:0043616~keratinocyte proliferation,GO:0045598~regulation of fat cell differentiation,GO:0045600~positive regulation of fat cell differentiation,GO:0045662~negative regulation of myoblast differentiation,GO:0045684~positive regulation of epidermis development,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045909~positive regulation of vasodilation,GO:0046697~decidualization,GO:0048662~negative regulation of smooth muscle cell proliferation,GO:0050680~negative regulation of epithelial cell proliferation,GO:0050728~negative regulation of inflammatory response,GO:0051546~keratinocyte migration,GO:0060612~adipose tissue development,GO:0071222~cellular response to lipopolysaccharide,GO:0071456~cellular response to hypoxia,GO:0097190~apoptotic signaling pathway,GO:1902894~negative regulation of pri-miRNA transcription from RNA polymerase II promoter,GO:2000288~positive regulation of myoblast proliferation, GO:0000790~nuclear chromatin,GO:0005634~nucleus,GO:0005654~nucleoplasm, GO:0001227~transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0003707~steroid hormone receptor activity,GO:0003713~transcription coactivator activity,GO:0004879~RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding,GO:0005504~fatty acid binding,GO:0005515~protein binding,GO:0008134~transcription factor binding,GO:0008144~drug binding,GO:0008270~zinc ion binding,GO:0008289~lipid binding,GO:0043565~sequence-specific DNA binding,GO:0046982~protein heterodimerization activity,GO:0051059~NF-kappaB binding,GO:0070539~linoleic acid binding, IPR000536:Nuclear hormone receptor, ligand-binding, core,IPR001628:Zinc finger, nuclear hormone receptor-type,IPR001723:Steroid hormone receptor,IPR003074:Peroxisome proliferator-activated receptor,IPR003075:Peroxisome proliferator-activated receptor, beta,IPR013088:Zinc finger, NHR/GATA-type, hsa03320:PPAR signaling pathway,hsa04310:Wnt signaling pathway,hsa05200:Pathways in cancer,hsa05221:Acute myeloid leukemia, SM00399:ZnF_C4,SM00430:HOLI, 3D-structure,Activator,Alternative splicing,Complete proteome,DNA-binding,Metal-binding,Nucleus,Receptor,Reference proteome,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Peroxisome proliferator-activated receptor delta,DNA-binding region:Nuclear receptor,helix,region of interest:Ligand-binding,sequence conflict,splice variant,strand,turn,zinc finger region:NR C4-type, Q15256 protein tyrosine phosphatase, receptor type R(PTPRR) Homo sapiens h_erkPathway:Erk1/Erk2 Mapk Signaling pathway, GO:0001701~in utero embryonic development,GO:0006470~protein dephosphorylation,GO:0010633~negative regulation of epithelial cell migration,GO:0035335~peptidyl-tyrosine dephosphorylation,GO:0038128~ERBB2 signaling pathway,GO:0070373~negative regulation of ERK1 and ERK2 cascade,GO:1903385~regulation of homophilic cell adhesion, GO:0005615~extracellular space,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0016021~integral component of membrane,GO:0030054~cell junction,GO:0048471~perinuclear region of cytoplasm, GO:0004725~protein tyrosine phosphatase activity,GO:0005001~transmembrane receptor protein tyrosine phosphatase activity,GO:0005515~protein binding,GO:0019901~protein kinase binding, IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR003595:Protein-tyrosine phosphatase, catalytic,IPR008356:Protein-tyrosine phosphatase, KIM-containing,IPR016130:Protein-tyrosine phosphatase, active site,IPR016334:Protein-tyrosine phosphatase, receptor type R/non-receptor type 5, hsa04010:MAPK signaling pathway, PIRSF001997:receptor tyrosine-protein phosphatase, types R/5, SM00194:PTPc,SM00404:PTPc_motif, 3D-structure,Alternative splicing,Cell membrane,Complete proteome,Cytoplasm,Glycoprotein,Hydrolase,Membrane,Phosphoprotein,Polymorphism,Protein phosphatase,Proteomics identification,Receptor,Reference proteome,Signal,Transmembrane,Transmembrane helix, active site:Phosphocysteine intermediate,chain:Receptor-type tyrosine-protein phosphatase R,domain:Tyrosine-protein phosphatase,glycosylation site:N-linked (GlcNAc...),helix,modified residue,sequence variant,signal peptide,splice variant,strand,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q9LGZ2 putative L-cysteine desulfhydrase 1(LOC4325155) Oryza sativa Japonica Group Posttranslational modification, protein turnover, chaperones, GO:0016829~lyase activity, IPR000192:Aminotransferase, class V/Cysteine desulfurase,IPR015421:Pyridoxal phosphate-dependent transferase, major region, subdomain 1,IPR015424:Pyridoxal phosphate-dependent transferase, Complete proteome,Lyase,Pyridoxal phosphate,Reference proteome, F1R983 retinoblastoma binding protein 8(rbbp8) Danio rerio GO:0000724~double-strand break repair via homologous recombination,GO:0006281~DNA repair,GO:0006974~cellular response to DNA damage stimulus,GO:0007049~cell cycle,GO:0007067~mitotic nuclear division,GO:0010792~DNA double-strand break processing involved in repair via single-strand annealing,GO:0051301~cell division,GO:0051321~meiotic cell cycle, GO:0005634~nucleus, GO:0003677~DNA binding,GO:0004518~nuclease activity,GO:0004519~endonuclease activity,GO:0016787~hydrolase activity,GO:0042578~phosphoric ester hydrolase activity,GO:0043765~T/G mismatch-specific endonuclease activity,GO:0044824~retroviral 3' processing activity, IPR013882:DNA repair protein Sae2/CtIP,IPR019518:Tumour-suppressor protein CtIP N-terminal, Cell cycle,Cell division,Coiled coil,Complete proteome,DNA damage,DNA repair,DNA-binding,Endonuclease,Hydrolase,Meiosis,Mitosis,Nuclease,Nucleus,Reference proteome, Q96AT9 ribulose-5-phosphate-3-epimerase(RPE) Homo sapiens GO:0005975~carbohydrate metabolic process,GO:0006098~pentose-phosphate shunt,GO:0009052~pentose-phosphate shunt, non-oxidative branch,GO:0019323~pentose catabolic process,GO:0044262~cellular carbohydrate metabolic process, GO:0005829~cytosol,GO:0070062~extracellular exosome, GO:0004750~ribulose-phosphate 3-epimerase activity,GO:0016857~racemase and epimerase activity, acting on carbohydrates and derivatives,GO:0042802~identical protein binding,GO:0042803~protein homodimerization activity,GO:0046872~metal ion binding, IPR000056:Ribulose-phosphate 3-epimerase-like,IPR011060:Ribulose-phosphate binding barrel,IPR013785:Aldolase-type TIM barrel,IPR026019:Ribulose-phosphate 3-epimerase, hsa00030:Pentose phosphate pathway,hsa00040:Pentose and glucuronate interconversions,hsa01100:Metabolic pathways,hsa01130:Biosynthesis of antibiotics,hsa01200:Carbon metabolism,hsa01230:Biosynthesis of amino acids, PIRSF001461:ribulose-phosphate 3-epimerase, 3D-structure,Acetylation,Alternative splicing,Carbohydrate metabolism,Cobalt,Complete proteome,Iron,Isomerase,Manganese,Metal-binding,Proteomics identification,Reference proteome,Zinc, chain:Ribulose-phosphate 3-epimerase,sequence conflict,splice variant, Q95JD5 sulfotransferase family 1B member 1(SULT1B1) Canis lupus familiaris GO:0006805~xenobiotic metabolic process,GO:0008202~steroid metabolic process,GO:0009812~flavonoid metabolic process,GO:0030855~epithelial cell differentiation,GO:0042403~thyroid hormone metabolic process,GO:0051923~sulfation, GO:0005737~cytoplasm, GO:0004062~aryl sulfotransferase activity,GO:0008146~sulfotransferase activity, IPR000863:Sulfotransferase domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, Complete proteome,Cytoplasm,Lipid metabolism,Reference proteome,Steroid metabolism,Transferase, active site:Proton acceptor,binding site:PAPS,chain:Sulfotransferase family cytosolic 1B member 1,nucleotide phosphate-binding region:PAPS, Q9QWG7 sulfotransferase family 1B, member 1(Sult1b1) Mus musculus GO:0006629~lipid metabolic process,GO:0006805~xenobiotic metabolic process,GO:0008202~steroid metabolic process,GO:0009812~flavonoid metabolic process,GO:0018958~phenol-containing compound metabolic process,GO:0030855~epithelial cell differentiation,GO:0042403~thyroid hormone metabolic process,GO:0051923~sulfation, GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0004062~aryl sulfotransferase activity,GO:0008146~sulfotransferase activity,GO:0016740~transferase activity, IPR000863:Sulfotransferase domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, Alternative splicing,Complete proteome,Cytoplasm,Lipid metabolism,Reference proteome,Steroid metabolism,Transferase, active site:Proton acceptor,binding site:PAPS,chain:Sulfotransferase family cytosolic 1B member 1,nucleotide phosphate-binding region:PAPS,sequence conflict,splice variant, O00338 sulfotransferase family 1C member 2(SULT1C2) Homo sapiens GO:0009308~amine metabolic process,GO:0050427~3'-phosphoadenosine 5'-phosphosulfate metabolic process,GO:0051923~sulfation, GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0070062~extracellular exosome, GO:0004062~aryl sulfotransferase activity,GO:0005515~protein binding,GO:0008146~sulfotransferase activity, IPR000863:Sulfotransferase domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, 3D-structure,Alternative splicing,Complete proteome,Cytoplasm,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transferase, active site:Proton acceptor,chain:Sulfotransferase 1C2,helix,nucleotide phosphate-binding region:PAPS,sequence variant,splice variant,strand,turn, O75897 sulfotransferase family 1C member 4(SULT1C4) Homo sapiens GO:0050427~3'-phosphoadenosine 5'-phosphosulfate metabolic process,GO:0051923~sulfation, GO:0005829~cytosol, GO:0004062~aryl sulfotransferase activity,GO:0008146~sulfotransferase activity, IPR000863:Sulfotransferase domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, 3D-structure,Alternative splicing,Complete proteome,Cytoplasm,Polymorphism,Reference proteome,Transferase, active site:Proton acceptor,chain:Sulfotransferase 1C4,helix,nucleotide phosphate-binding region:PAPS,sequence variant,strand,turn, Q9CQM5 thioredoxin domain containing 17(Txndc17) Mus musculus GO:0033209~tumor necrosis factor-mediated signaling pathway, GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0070062~extracellular exosome, GO:0004601~peroxidase activity,GO:0047134~protein-disulfide reductase activity, IPR010357:Protein of unknown function DUF953, thioredoxin-like,IPR012336:Thioredoxin-like fold, 3D-structure,Acetylation,Complete proteome,Cytoplasm,Disulfide bond,Redox-active center,Reference proteome, active site:Nucleophile,chain:Thioredoxin domain-containing protein 17,disulfide bond,domain:Thioredoxin,helix,modified residue,sequence conflict,site:Contributes to redox potential value,strand, Q4QQM4 transformation related protein 53 inducible protein 11(Trp53i11) Mus musculus GO:0016020~membrane,GO:0016021~integral component of membrane, Complete proteome,Membrane,Phosphoprotein,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix, Q4V7N7 transmembrane protein 18 L homeolog(tmem18.L) Xenopus laevis GO:0016021~integral component of membrane,GO:0031965~nuclear membrane, GO:0003677~DNA binding, IPR026721:Transmembrane protein 18, Coiled coil,DNA-binding,Membrane,Nucleus,Transmembrane,Transmembrane helix, chain:Transmembrane protein 18,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q96RT7 tubulin gamma complex associated protein 6(TUBGCP6) Homo sapiens GO:0007020~microtubule nucleation,GO:0007126~meiotic nuclear division,GO:0031122~cytoplasmic microtubule organization,GO:0051298~centrosome duplication,GO:0051415~interphase microtubule nucleation by interphase microtubule organizing center,GO:0090307~mitotic spindle assembly, GO:0000922~spindle pole,GO:0000923~equatorial microtubule organizing center,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005815~microtubule organizing center,GO:0005816~spindle pole body,GO:0005829~cytosol,GO:0005874~microtubule,GO:0008274~gamma-tubulin ring complex,GO:0016020~membrane,GO:0070062~extracellular exosome, GO:0005200~structural constituent of cytoskeleton,GO:0008017~microtubule binding,GO:0043015~gamma-tubulin binding,GO:0051011~microtubule minus-end binding, IPR007259:Spc97/Spc98, 251270~Microcephaly and chorioretinopathy, autosomal recessive, 1, Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Microtubule,Polymorphism,Proteomics identification,Reference proteome,Repeat, chain:Gamma-tubulin complex component 6,modified residue,region of interest:9 X 27 AA tandem repeats,repeat:1,repeat:2,repeat:3,repeat:4,repeat:5,repeat:6,repeat:7,repeat:8,repeat:9,sequence variant,splice variant, Q23K29 tubulin glycylase 3C(TTHERM_00196050) Tetrahymena thermophila SB210 GO:0018094~protein polyglycylation, GO:0005737~cytoplasm, GO:0005524~ATP binding,GO:0070735~protein-glycine ligase activity, IPR004344:Tubulin-tyrosine ligase, ATP-binding,Complete proteome,Cytoplasm,Ligase,Nucleotide-binding,Reference proteome, chain:Tubulin glycylase 3D,compositionally biased region:Gln-rich,domain:TTL, Q0VCQ8 tumor protein p53 inducible protein 11(TP53I11) Bos taurus GO:0016021~integral component of membrane, Complete proteome,Membrane,Phosphoprotein,Reference proteome,Transmembrane,Transmembrane helix, Q8IV45 unc-5 family C-terminal like(UNC5CL) Homo sapiens GO:0006508~proteolysis,GO:0007165~signal transduction,GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling,GO:0046330~positive regulation of JNK cascade, GO:0005737~cytoplasm,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0008233~peptidase activity, IPR000488:Death domain,IPR000906:ZU5,IPR011029:Death-like domain, SM00005:DEATH,SM00218:ZU5, Complete proteome,Cytoplasm,Membrane,Polymorphism,Reference proteome,Transmembrane,Transmembrane helix, chain:UNC5C-like protein,domain:Death,domain:ZU5,region of interest:Interaction with RELA and NFKB1,sequence variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q80TY5 vacuolar protein sorting 13B(Vps13b) Mus musculus Intracellular trafficking and secretion, GO:0006810~transport,GO:0015031~protein transport, GO:0016021~integral component of membrane, IPR009543:Vacuolar protein sorting-associated protein 13 domain,IPR026854:Vacuolar protein sorting-associated protein 13A N-terminal domain, Complete proteome,Membrane,Phosphoprotein,Protein transport,Proteomics identification,Reference proteome,Signal,Transmembrane,Transmembrane helix,Transport, chain:Vacuolar protein sorting-associated protein 13B,modified residue,sequence conflict, Q8K2R5 zinc finger protein 668(Zfp668) Mus musculus General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0046872~metal ion binding, IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00355:ZnF_C2H2, Acetylation,Complete proteome,DNA-binding,Metal-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 668,sequence conflict,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 10,zinc finger region:C2H2-type 11,zinc finger region:C2H2-type 12,zinc finger region:C2H2-type 13,zinc finger region:C2H2-type 14,zinc finger region:C2H2-type 15,zinc finger region:C2H2-type 16,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9,