ID Gene Name Species BBID BIOCARTA COG_ONTOLOGY GOTERM_BP_DIRECT GOTERM_CC_DIRECT GOTERM_MF_DIRECT INTERPRO KEGG_PATHWAY OMIM_DISEASE PIR_SUPERFAMILY SMART UP_KEYWORDS UP_SEQ_FEATURE Q04446 1,4-alpha-glucan branching enzyme 1(GBE1) Homo sapiens Carbohydrate transport and metabolism, GO:0005977~glycogen metabolic process,GO:0005978~glycogen biosynthetic process,GO:0006091~generation of precursor metabolites and energy, GO:0005829~cytosol,GO:0070062~extracellular exosome, GO:0003844~1,4-alpha-glucan branching enzyme activity,GO:0004553~hydrolase activity, hydrolyzing O-glycosyl compounds,GO:0030246~carbohydrate binding,GO:0043169~cation binding, IPR004193:Glycoside hydrolase, family 13, N-terminal,IPR006047:Glycosyl hydrolase, family 13, catalytic domain,IPR006048:Alpha-amylase, C-terminal all beta,IPR006407:1,4-alpha-glucan-branching enzyme,IPR013780:Glycosyl hydrolase, family 13, all-beta,IPR013781:Glycoside hydrolase, catalytic domain,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR015902:Glycoside hydrolase, family 13,IPR017853:Glycoside hydrolase, superfamily, hsa00500:Starch and sucrose metabolism,hsa01100:Metabolic pathways, 232500~Glycogen storage disease IV,263570~Polyglucosan body disease, adult form, PIRSF000463:1,4-alpha-glucan branching enzyme, SM00642:Aamy, 3D-structure,Acetylation,Complete proteome,Disease mutation,Glycogen biosynthesis,Glycogen storage disease,Glycosyltransferase,Neuropathy,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transferase, chain:1,4-alpha-glucan-branching enzyme,modified residue,sequence conflict,sequence variant, Q8Z3G5 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC(STY3495) Salmonella enterica subsp. enterica serovar Typhi str. CT18 GO:0009103~lipopolysaccharide biosynthetic process, GO:0019143~3-deoxy-manno-octulosonate-8-phosphatase activity,GO:0046872~metal ion binding, IPR010023:3-deoxy-D-manno-octulosonate 8-phosphate phosphatase,IPR023214:HAD-like domain, sty00540:Lipopolysaccharide biosynthesis,sty01100:Metabolic pathways, PIRSF006118:3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, Complete proteome,Hydrolase,Lipopolysaccharide biosynthesis,Magnesium,Metal-binding, chain:3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, Q9H0P0 5'-nucleotidase, cytosolic IIIA(NT5C3A) Homo sapiens GO:0006213~pyrimidine nucleoside metabolic process,GO:0009117~nucleotide metabolic process,GO:0016311~dephosphorylation,GO:0046085~adenosine metabolic process,GO:0046135~pyrimidine nucleoside catabolic process, GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0005783~endoplasmic reticulum,GO:0005829~cytosol, GO:0000166~nucleotide binding,GO:0000287~magnesium ion binding,GO:0008253~5'-nucleotidase activity,GO:0008665~2'-phosphotransferase activity, IPR006434:Pyrimidine 5'-nucleotidase, eukaryotic,IPR023214:HAD-like domain, hsa00230:Purine metabolism,hsa00240:Pyrimidine metabolism,hsa00760:Nicotinate and nicotinamide metabolism,hsa01100:Metabolic pathways, 266120~Anemia, hemolytic, due to UMPH1 deficiency, 3D-structure,Alternative splicing,Complete proteome,Cytoplasm,Direct protein sequencing,Disease mutation,Endoplasmic reticulum,Hydrolase,Magnesium,Metal-binding,Nucleotide metabolism,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome,Transferase, active site:Nucleophile,active site:Proton donor,binding site:Substrate,chain:Cytosolic 5'-nucleotidase 3,helix,metal ion-binding site:Magnesium,metal ion-binding site:Magnesium; via carbonyl oxygen,mutagenesis site,region of interest:Substrate binding,sequence conflict,sequence variant,splice variant,strand,turn, Q969T7 5'-nucleotidase, cytosolic IIIB(NT5C3B) Homo sapiens GO:0009117~nucleotide metabolic process,GO:0016311~dephosphorylation,GO:0043928~exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay, GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0000166~nucleotide binding,GO:0000287~magnesium ion binding,GO:0005515~protein binding,GO:0008253~5'-nucleotidase activity, IPR006434:Pyrimidine 5'-nucleotidase, eukaryotic,IPR023214:HAD-like domain, hsa00230:Purine metabolism,hsa00240:Pyrimidine metabolism,hsa00760:Nicotinate and nicotinamide metabolism,hsa01100:Metabolic pathways, Acetylation,Alternative splicing,Complete proteome,Cytoplasm,Hydrolase,Magnesium,Metal-binding,Nucleotide metabolism,Nucleotide-binding,Polymorphism,Proteomics identification,Reference proteome, active site:Nucleophile,active site:Proton donor,binding site:Substrate,chain:Cytosolic 5'-nucleotidase III-like protein,metal ion-binding site:Magnesium,metal ion-binding site:Magnesium; via carbonyl oxygen,modified residue,region of interest:Substrate binding,sequence variant, P14842 5-hydroxytryptamine receptor 2A(Htr2a) Rattus norvegicus GO:0001659~temperature homeostasis,GO:0006874~cellular calcium ion homeostasis,GO:0007186~G-protein coupled receptor signaling pathway,GO:0007193~adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway,GO:0007202~activation of phospholipase C activity,GO:0007204~positive regulation of cytosolic calcium ion concentration,GO:0007208~phospholipase C-activating serotonin receptor signaling pathway,GO:0007210~serotonin receptor signaling pathway,GO:0007568~aging,GO:0007613~memory,GO:0008219~cell death,GO:0008284~positive regulation of cell proliferation,GO:0010513~positive regulation of phosphatidylinositol biosynthetic process,GO:0014059~regulation of dopamine secretion,GO:0014065~phosphatidylinositol 3-kinase signaling,GO:0014824~artery smooth muscle contraction,GO:0014832~urinary bladder smooth muscle contraction,GO:0019233~sensory perception of pain,GO:0030431~sleep,GO:0033674~positive regulation of kinase activity,GO:0042493~response to drug,GO:0043267~negative regulation of potassium ion transport,GO:0043406~positive regulation of MAP kinase activity,GO:0044380~protein localization to cytoskeleton,GO:0045600~positive regulation of fat cell differentiation,GO:0045821~positive regulation of glycolytic process,GO:0045907~positive regulation of vasoconstriction,GO:0046883~regulation of hormone secretion,GO:0048148~behavioral response to cocaine,GO:0050731~positive regulation of peptidyl-tyrosine phosphorylation,GO:0050795~regulation of behavior,GO:0050965~detection of temperature stimulus involved in sensory perception of pain,GO:0050966~detection of mechanical stimulus involved in sensory perception of pain,GO:0051209~release of sequestered calcium ion into cytosol,GO:0051967~negative regulation of synaptic transmission, glutamatergic,GO:0070374~positive regulation of ERK1 and ERK2 cascade, GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0005901~caveola,GO:0016020~membrane,GO:0016023~cytoplasmic, membrane-bounded vesicle,GO:0030424~axon,GO:0030425~dendrite,GO:0031410~cytoplasmic vesicle,GO:0043025~neuronal cell body,GO:0043198~dendritic shaft,GO:0070852~cell body fiber, GO:0001965~G-protein alpha-subunit binding,GO:0004993~G-protein coupled serotonin receptor activity,GO:0005515~protein binding,GO:0008144~drug binding,GO:0030594~neurotransmitter receptor activity,GO:0032403~protein complex binding,GO:0051378~serotonin binding,GO:0071886~1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, IPR000276:G protein-coupled receptor, rhodopsin-like,IPR000455:5-Hydroxytryptamine 2A receptor,IPR002231:5-Hydroxytryptamine receptor family,IPR017452:GPCR, rhodopsin-like, 7TM, rno04020:Calcium signaling pathway,rno04080:Neuroactive ligand-receptor interaction,rno04540:Gap junction,rno04726:Serotonergic synapse,rno04750:Inflammatory mediator regulation of TRP channels, SM01381:SM01381, 3D-structure,Behavior,Cell membrane,Cell projection,Complete proteome,Cytoplasmic vesicle,Disulfide bond,G-protein coupled receptor,Glycoprotein,Membrane,Phosphoprotein,Receptor,Reference proteome,Transducer,Transmembrane,Transmembrane helix, chain:5-hydroxytryptamine receptor 2A,disulfide bond,glycosylation site:N-linked (GlcNAc...),short sequence motif:PDZ-binding,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q90W95 6-pyruvoyltetrahydropterin synthase(pts) Poecilia reticulata GO:0006729~tetrahydrobiopterin biosynthetic process, GO:0003874~6-pyruvoyltetrahydropterin synthase activity,GO:0046872~metal ion binding, IPR007115:6-pyruvoyl tetrahydropterin synthase/QueD family protein,IPR022469:6-pyruvoyl tetrahydropterin synthase, histidine active site,IPR022470:6-pyruvoyl tetrahydropterin synthase, cysteine active site, Alternative splicing,Lyase,Metal-binding,Tetrahydrobiopterin biosynthesis,Zinc, Q17BU3 AAEL004812-PA(KIF1A_AEDAE) Aedes aegypti GO:0047496~vesicle transport along microtubule,GO:0048489~synaptic vesicle transport, GO:0005737~cytoplasm,GO:0005874~microtubule,GO:0005875~microtubule associated complex, GO:0003777~microtubule motor activity,GO:0005524~ATP binding, IPR000253:Forkhead-associated (FHA) domain,IPR001752:Kinesin, motor domain,IPR001849:Pleckstrin homology domain,IPR008984:SMAD/FHA domain,IPR011993:Pleckstrin homology-like domain,IPR019821:Kinesin, motor region, conserved site,IPR022140:Kinesin protein 1B,IPR022164:Kinesin-like,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00129:KISc,SM00233:PH,SM00240:FHA, ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Microtubule,Motor protein,Nucleotide-binding,Reference proteome, chain:Kinesin-like protein unc-104,domain:FHA,domain:Kinesin-motor,domain:PH,nucleotide phosphate-binding region:ATP, Q9P2N4 ADAM metallopeptidase with thrombospondin type 1 motif 9(ADAMTS9) Homo sapiens GO:0006508~proteolysis,GO:0006516~glycoprotein catabolic process,GO:0007275~multicellular organism development,GO:0015031~protein transport,GO:0016192~vesicle-mediated transport,GO:0045636~positive regulation of melanocyte differentiation, GO:0005578~proteinaceous extracellular matrix,GO:0005615~extracellular space,GO:0005783~endoplasmic reticulum,GO:0009986~cell surface,GO:0031012~extracellular matrix, GO:0004222~metalloendopeptidase activity,GO:0008237~metallopeptidase activity,GO:0008270~zinc ion binding, IPR000884:Thrombospondin, type 1 repeat,IPR001590:Peptidase M12B, ADAM/reprolysin,IPR002870:Peptidase M12B, propeptide,IPR010294:ADAM-TS Spacer 1,IPR012314:Peptidase M12B, GON-ADAMTSs,IPR013273:Peptidase M12B, ADAM-TS,IPR024079:Metallopeptidase, catalytic domain, SM00209:TSP1, Alternative splicing,Cleavage on pair of basic residues,Complete proteome,Disulfide bond,Endoplasmic reticulum,ER-Golgi transport,Extracellular matrix,Glycoprotein,Hydrolase,Metal-binding,Metalloprotease,Polymorphism,Protease,Protein transport,Reference proteome,Repeat,Secreted,Signal,Transport,Zinc,Zymogen, chain:A disintegrin and metalloproteinase with thrombospondin motifs 9,compositionally biased region:Cys-rich,compositionally biased region:Poly-Ser,disulfide bond,domain:Disintegrin,domain:GON,domain:Peptidase M12B,domain:TSP type-1 1,domain:TSP type-1 10,domain:TSP type-1 11,domain:TSP type-1 12,domain:TSP type-1 13,domain:TSP type-1 14,domain:TSP type-1 15,domain:TSP type-1 2,domain:TSP type-1 3,domain:TSP type-1 4,domain:TSP type-1 5,domain:TSP type-1 6,domain:TSP type-1 7,domain:TSP type-1 8,domain:TSP type-1 9,glycosylation site:N-linked (GlcNAc...),metal ion-binding site:Zinc; catalytic,metal ion-binding site:Zinc; in inhibited form,region of interest:Spacer,sequence conflict,sequence variant,short sequence motif:Cysteine switch,signal peptide,splice variant, Q969Q4 ADP ribosylation factor like GTPase 11(ARL11) Homo sapiens GO:0002244~hematopoietic progenitor cell differentiation,GO:0007264~small GTPase mediated signal transduction, GO:0005622~intracellular, GO:0005515~protein binding,GO:0005525~GTP binding, IPR005225:Small GTP-binding protein domain,IPR006689:Small GTPase superfamily, ARF/SAR type,IPR024156:Small GTPase superfamily, ARF type,IPR027417:P-loop containing nucleoside triphosphate hydrolase, Complete proteome,GTP-binding,Lipoprotein,Myristate,Nucleotide-binding,Polymorphism,Reference proteome, chain:ADP-ribosylation factor-like protein 11,lipid moiety-binding region:N-myristoyl glycine,modified residue,nucleotide phosphate-binding region:GTP,sequence variant, Q7PR68 AGAP002823-PA(MED7_ANOGA) Anopheles gambiae str. PEST GO:0006351~transcription, DNA-templated, GO:0016592~mediator complex,GO:0070847~core mediator complex, GO:0001104~RNA polymerase II transcription cofactor activity, IPR009244:Mediator complex, subunit Med7, Activator,Complete proteome,Nucleus,Reference proteome,Transcription,Transcription regulation, chain:Mediator of RNA polymerase II transcription subunit 7, Q7PHR1 AGAP010519-PA(KIF1A_ANOGA) Anopheles gambiae str. PEST GO:0007018~microtubule-based movement,GO:0030705~cytoskeleton-dependent intracellular transport,GO:0047496~vesicle transport along microtubule,GO:0048489~synaptic vesicle transport, GO:0005737~cytoplasm,GO:0005871~kinesin complex,GO:0005874~microtubule,GO:0005875~microtubule associated complex, GO:0003777~microtubule motor activity,GO:0005524~ATP binding,GO:0016887~ATPase activity, IPR000253:Forkhead-associated (FHA) domain,IPR001752:Kinesin, motor domain,IPR001849:Pleckstrin homology domain,IPR008984:SMAD/FHA domain,IPR011993:Pleckstrin homology-like domain,IPR019821:Kinesin, motor region, conserved site,IPR022140:Kinesin protein 1B,IPR022164:Kinesin-like,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00129:KISc,SM00233:PH,SM00240:FHA, ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Microtubule,Motor protein,Nucleotide-binding,Reference proteome, chain:Kinesin-like protein unc-104,domain:FHA,domain:Kinesin-motor,domain:PH,nucleotide phosphate-binding region:ATP, P61158 ARP3 actin related protein 3 homolog(ACTR3) Homo sapiens h_actinYPathway:Y branching of actin filaments,h_cdc42racPathway:Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration,h_mPRPathway:How Progesterone Initiates the Oocyte Maturation,h_rhoPathway:Rho cell motility signaling pathway,h_salmonellaPathway:How does salmonella hijack a cell, GO:0006928~movement of cell or subcellular component,GO:0007163~establishment or maintenance of cell polarity,GO:0008356~asymmetric cell division,GO:0016344~meiotic chromosome movement towards spindle pole,GO:0033206~meiotic cytokinesis,GO:0034314~Arp2/3 complex-mediated actin nucleation,GO:0038096~Fc-gamma receptor signaling pathway involved in phagocytosis,GO:0048013~ephrin receptor signaling pathway,GO:0051653~spindle localization,GO:0060271~cilium morphogenesis, GO:0005829~cytosol,GO:0005885~Arp2/3 protein complex,GO:0005903~brush border,GO:0005911~cell-cell junction,GO:0005925~focal adhesion,GO:0015629~actin cytoskeleton,GO:0016020~membrane,GO:0030027~lamellipodium,GO:0070062~extracellular exosome, GO:0005200~structural constituent of cytoskeleton,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0051015~actin filament binding, IPR004000:Actin-related protein,IPR015623:Actin-related protein 3 (Arp3),IPR020902:Actin/actin-like conserved site, SM00268:ACTIN, Acetylation,Actin-binding,ATP-binding,Cell projection,Cilium biogenesis/degradation,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Nucleotide-binding,Proteomics identification,Reference proteome, chain:Actin-related protein 3,modified residue, D2I1E3 ARP8 actin-related protein 8 homolog(ACTR8) Ailuropoda melanoleuca GO:0006281~DNA repair,GO:0006310~DNA recombination,GO:0006338~chromatin remodeling,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007067~mitotic nuclear division,GO:0051301~cell division, GO:0005813~centrosome,GO:0031011~Ino80 complex, GO:0005524~ATP binding, IPR004000:Actin-related protein, SM00268:ACTIN, Acetylation,ATP-binding,Cell cycle,Cell division,Chromosome,Complete proteome,DNA damage,DNA recombination,DNA repair,Mitosis,Nucleotide-binding,Nucleus,Phosphoprotein,Reference proteome,Transcription,Transcription regulation, Q7Z591 AT-hook transcription factor(AKNA) Homo sapiens GO:0006366~transcription from RNA polymerase II promoter,GO:0045944~positive regulation of transcription from RNA polymerase II promoter, GO:0005634~nucleus,GO:0016020~membrane, GO:0000978~RNA polymerase II core promoter proximal region sequence-specific DNA binding,GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding, IPR022150:Transcription factor, AT-hook-containing, Activator,Alternative splicing,Coiled coil,Complete proteome,DNA-binding,Nucleus,Phosphoprotein,Polymorphism,Reference proteome,Transcription,Transcription regulation, chain:AT-hook-containing transcription factor,DNA-binding region:A.T hook,modified residue,region of interest:PEST,sequence conflict,sequence variant,splice variant, Q86UK0 ATP binding cassette subfamily A member 12(ABCA12) Homo sapiens GO:0006869~lipid transport,GO:0010875~positive regulation of cholesterol efflux,GO:0019725~cellular homeostasis,GO:0031424~keratinization,GO:0032940~secretion by cell,GO:0033700~phospholipid efflux,GO:0035627~ceramide transport,GO:0043129~surfactant homeostasis,GO:0045055~regulated exocytosis,GO:0048286~lung alveolus development,GO:0055085~transmembrane transport,GO:0055088~lipid homeostasis,GO:0061436~establishment of skin barrier,GO:0072659~protein localization to plasma membrane,GO:2000010~positive regulation of protein localization to cell surface, GO:0005737~cytoplasm,GO:0005743~mitochondrial inner membrane,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0016021~integral component of membrane,GO:0097209~epidermal lamellar body, GO:0005102~receptor binding,GO:0005215~transporter activity,GO:0005319~lipid transporter activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016887~ATPase activity,GO:0034040~lipid-transporting ATPase activity,GO:0034191~apolipoprotein A-I receptor binding,GO:0042626~ATPase activity, coupled to transmembrane movement of substances, IPR003439:ABC transporter-like,IPR003593:AAA+ ATPase domain,IPR017871:ABC transporter, conserved site,IPR026082:ABC transporter A, ABCA,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa02010:ABC transporters, 242500~Ichthyosis, autosomal recessive 4B (harlequin),601277~Ichthyosis, congenital, autosomal recessive 4A, SM00382:AAA, Alternative splicing,ATP-binding,Complete proteome,Disease mutation,Glycoprotein,Ichthyosis,Membrane,Nucleotide-binding,Polymorphism,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Transport, chain:ATP-binding cassette sub-family A member 12,domain:ABC transporter 1,domain:ABC transporter 2,glycosylation site:N-linked (GlcNAc...),nucleotide phosphate-binding region:ATP 1,nucleotide phosphate-binding region:ATP 2,sequence conflict,sequence variant,splice variant,transmembrane region, Q08D64 ATP binding cassette subfamily B member 6 (Langereis blood group)(abcb6) Xenopus tropicalis Posttranslational modification, protein turnover, chaperones, GO:0006879~cellular iron ion homeostasis,GO:0055085~transmembrane transport, GO:0005741~mitochondrial outer membrane,GO:0005743~mitochondrial inner membrane,GO:0005783~endoplasmic reticulum,GO:0005794~Golgi apparatus,GO:0005886~plasma membrane,GO:0016021~integral component of membrane, GO:0005524~ATP binding,GO:0042626~ATPase activity, coupled to transmembrane movement of substances, IPR003439:ABC transporter-like,IPR003593:AAA+ ATPase domain,IPR011527:ABC transporter, transmembrane domain, type 1,IPR017871:ABC transporter, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, xtr02010:ABC transporters, SM00382:AAA, ATP-binding,Cell membrane,Complete proteome,Endoplasmic reticulum,Golgi apparatus,Membrane,Mitochondrion,Mitochondrion outer membrane,Nucleotide-binding,Reference proteome,Transmembrane,Transmembrane helix,Transport, chain:ATP-binding cassette sub-family B member 6, mitochondrial,domain:ABC transmembrane type-1,domain:ABC transporter,nucleotide phosphate-binding region:ATP,transmembrane region, O15439 ATP binding cassette subfamily C member 4(ABCC4) Homo sapiens Defense mechanisms, GO:0002576~platelet degranulation,GO:0010243~response to organonitrogen compound,GO:0014070~response to organic cyclic compound,GO:0032310~prostaglandin secretion,GO:0042384~cilium assembly,GO:0042493~response to drug,GO:0048661~positive regulation of smooth muscle cell proliferation,GO:0055085~transmembrane transport,GO:0055114~oxidation-reduction process,GO:0098656~anion transmembrane transport, GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0016323~basolateral plasma membrane,GO:0031088~platelet dense granule membrane, GO:0005524~ATP binding,GO:0015662~ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism,GO:0016404~15-hydroxyprostaglandin dehydrogenase (NAD+) activity,GO:0042626~ATPase activity, coupled to transmembrane movement of substances,GO:0043225~anion transmembrane-transporting ATPase activity, IPR003439:ABC transporter-like,IPR003593:AAA+ ATPase domain,IPR011527:ABC transporter, transmembrane domain, type 1,IPR017871:ABC transporter, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa02010:ABC transporters,hsa04024:cAMP signaling pathway,hsa04976:Bile secretion, SM00382:AAA, Alternative splicing,ATP-binding,Complete proteome,Glycoprotein,Membrane,Nucleotide-binding,Phosphoprotein,Polymorphism,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Transport, chain:Multidrug resistance-associated protein 4,domain:ABC transmembrane type-1 1,domain:ABC transmembrane type-1 2,domain:ABC transporter 1,domain:ABC transporter 2,glycosylation site:N-linked (GlcNAc...),modified residue,nucleotide phosphate-binding region:ATP 1,nucleotide phosphate-binding region:ATP 2,sequence conflict,sequence variant,splice variant,transmembrane region, Q767L0 ATP binding cassette subfamily F member 1(ABCF1) Sus scrofa General function prediction only, GO:0006413~translational initiation,GO:0042254~ribosome biogenesis,GO:0045727~positive regulation of translation, GO:0005635~nuclear envelope,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0042788~polysomal ribosome, GO:0005524~ATP binding,GO:0008494~translation activator activity,GO:0016887~ATPase activity,GO:0043022~ribosome binding, IPR003439:ABC transporter-like,IPR003593:AAA+ ATPase domain,IPR017871:ABC transporter, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00382:AAA, Activator,ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Isopeptide bond,Nucleotide-binding,Nucleus,Phosphoprotein,Reference proteome,Repeat, chain:ATP-binding cassette sub-family F member 1,compositionally biased region:Poly-Glu,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),domain:ABC transporter 1,domain:ABC transporter 2,modified residue,nucleotide phosphate-binding region:ATP 1,nucleotide phosphate-binding region:ATP 2, Q91V92 ATP citrate lyase(Acly) Mus musculus m_malatexPathway:Shuttle for transfer of acetyl groups from mitochondria to the cytosol, Energy production and conversion, GO:0006084~acetyl-CoA metabolic process,GO:0006085~acetyl-CoA biosynthetic process,GO:0006101~citrate metabolic process,GO:0006107~oxaloacetate metabolic process,GO:0006629~lipid metabolic process,GO:0006633~fatty acid biosynthetic process,GO:0008152~metabolic process,GO:0008610~lipid biosynthetic process, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0009346~citrate lyase complex,GO:0016020~membrane,GO:0070062~extracellular exosome, GO:0000166~nucleotide binding,GO:0003824~catalytic activity,GO:0003878~ATP citrate synthase activity,GO:0005524~ATP binding,GO:0016740~transferase activity,GO:0046872~metal ion binding,GO:0046912~transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer,GO:0048037~cofactor binding, IPR002020:Citrate synthase-like,IPR003781:CoA-binding,IPR005810:Succinyl-CoA ligase, alpha subunit,IPR005811:ATP-citrate lyase/succinyl-CoA ligase,IPR013816:ATP-grasp fold, subdomain 2,IPR014608:ATP-citrate synthase,IPR016040:NAD(P)-binding domain,IPR016102:Succinyl-CoA synthetase-like,IPR016142:Citrate synthase-like, large alpha subdomain,IPR016143:Citrate synthase-like, small alpha subdomain,IPR017440:ATP-citrate lyase/succinyl-CoA ligase, active site,IPR017866:Succinyl-CoA synthetase, beta subunit, conserved site, mmu00020:Citrate cycle (TCA cycle),mmu01100:Metabolic pathways,mmu01130:Biosynthesis of antibiotics, PIRSF036511:ATP citrate synthase, fused large and small subunits, SM00881:SM00881, Acetylation,ATP-binding,Complete proteome,Cytoplasm,Lipid biosynthesis,Lipid metabolism,Magnesium,Metal-binding,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome,Transferase,Ubl conjugation, active site:Tele-phosphohistidine intermediate,chain:ATP-citrate synthase,metal ion-binding site:Magnesium,modified residue,nucleotide phosphate-binding region:ATP,region of interest:CoA-binding, P55096 ATP-binding cassette, sub-family D (ALD), member 3(Abcd3) Mus musculus m_nuclearRsPathway:Nuclear Receptors in Lipid Metabolism and Toxicity, GO:0006633~fatty acid biosynthetic process,GO:0006635~fatty acid beta-oxidation,GO:0006810~transport,GO:0007031~peroxisome organization,GO:0014070~response to organic cyclic compound,GO:0015910~peroxisomal long-chain fatty acid import,GO:0042493~response to drug,GO:0042760~very long-chain fatty acid catabolic process,GO:0055085~transmembrane transport, GO:0005739~mitochondrion,GO:0005743~mitochondrial inner membrane,GO:0005777~peroxisome,GO:0005778~peroxisomal membrane,GO:0005782~peroxisomal matrix,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0043231~intracellular membrane-bounded organelle, GO:0000166~nucleotide binding,GO:0005324~long-chain fatty acid transporter activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016887~ATPase activity,GO:0042626~ATPase activity, coupled to transmembrane movement of substances,GO:0042803~protein homodimerization activity,GO:0043621~protein self-association, IPR003439:ABC transporter-like,IPR003593:AAA+ ATPase domain,IPR005283:Peroxysomal long chain fatty acyl transporter,IPR011527:ABC transporter, transmembrane domain, type 1,IPR017871:ABC transporter, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, mmu02010:ABC transporters,mmu04146:Peroxisome, SM00382:AAA, Acetylation,ATP-binding,Complete proteome,Glycoprotein,Membrane,Nucleotide-binding,Peroxisome,Phosphoprotein,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix,Transport, chain:ATP-binding cassette sub-family D member 3,domain:ABC transmembrane type-1,domain:ABC transporter,glycosylation site:N-linked (GlcNAc...),modified residue,nucleotide phosphate-binding region:ATP,region of interest:Interaction with PEX19,region of interest:Targeting to peroxisomes,sequence conflict,transmembrane region, P54813 ATP-dependent zinc metalloprotease YME1 homolog(ymel-1) Caenorhabditis elegans GO:0006508~proteolysis,GO:0006515~misfolded or incompletely synthesized protein catabolic process,GO:0007005~mitochondrion organization, GO:0005743~mitochondrial inner membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0000166~nucleotide binding,GO:0004176~ATP-dependent peptidase activity,GO:0004222~metalloendopeptidase activity,GO:0005524~ATP binding,GO:0008233~peptidase activity,GO:0008237~metallopeptidase activity,GO:0016787~hydrolase activity,GO:0046872~metal ion binding, IPR000642:Peptidase M41,IPR003593:AAA+ ATPase domain,IPR003959:ATPase, AAA-type, core,IPR003960:ATPase, AAA-type, conserved site,IPR005936:Peptidase, FtsH,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00382:AAA, ATP-binding,Complete proteome,Hydrolase,Membrane,Metal-binding,Metalloprotease,Nucleotide-binding,Protease,Reference proteome,Transmembrane,Transmembrane helix,Zinc, chain:Protein YME1 homolog,metal ion-binding site:Zinc; catalytic,nucleotide phosphate-binding region:ATP, A9JRL3 ATP/GTP binding protein 1(agtpbp1) Xenopus tropicalis GO:0001754~eye photoreceptor cell differentiation,GO:0007005~mitochondrion organization,GO:0021702~cerebellar Purkinje cell differentiation,GO:0021772~olfactory bulb development,GO:0035609~C-terminal protein deglutamylation,GO:0035610~protein side chain deglutamylation,GO:0043009~chordate embryonic development,GO:0050905~neuromuscular process, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0005829~cytosol, GO:0004181~metallocarboxypeptidase activity,GO:0008270~zinc ion binding,GO:0015631~tubulin binding, IPR000834:Peptidase M14, carboxypeptidase A,IPR016024:Armadillo-type fold, Carboxypeptidase,Complete proteome,Cytoplasm,Hydrolase,Metal-binding,Metalloprotease,Mitochondrion,Nucleus,Protease,Reference proteome,Zinc, Q9H7F0 ATPase 13A3(ATP13A3) Homo sapiens GO:0006812~cation transport,GO:0006874~cellular calcium ion homeostasis,GO:0098655~cation transmembrane transport, GO:0005887~integral component of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0043231~intracellular membrane-bounded organelle, GO:0005524~ATP binding,GO:0016887~ATPase activity,GO:0019829~cation-transporting ATPase activity,GO:0046872~metal ion binding, IPR001757:Cation-transporting P-type ATPase,IPR004014:Cation-transporting P-type ATPase, N-terminal,IPR006068:Cation-transporting P-type ATPase, C-terminal,IPR006544:Cation-transporting P-type ATPase, subfamily V,IPR008250:P-type ATPase, A domain,IPR018303:P-type ATPase, phosphorylation site,IPR023214:HAD-like domain,IPR023299:P-type ATPase, cytoplasmic domain N, Alternative splicing,ATP-binding,Complete proteome,Hydrolase,Magnesium,Membrane,Metal-binding,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix, active site:4-aspartylphosphate intermediate,chain:Probable cation-transporting ATPase 13A3,compositionally biased region:Poly-Tyr,metal ion-binding site:Magnesium,modified residue,sequence conflict,splice variant,transmembrane region, Q4QY64 ATPase family, AAA domain containing 5(Atad5) Mus musculus GO:0002377~immunoglobulin production,GO:0006974~cellular response to DNA damage stimulus,GO:0030890~positive regulation of B cell proliferation,GO:0033260~nuclear DNA replication,GO:0048304~positive regulation of isotype switching to IgG isotypes,GO:1901990~regulation of mitotic cell cycle phase transition, GO:0005634~nucleus, GO:0000166~nucleotide binding,GO:0005524~ATP binding, IPR003593:AAA+ ATPase domain,IPR003959:ATPase, AAA-type, core,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00382:AAA, Alternative splicing,ATP-binding,Complete proteome,DNA damage,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome, chain:ATPase family AAA domain-containing protein 5,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,short sequence motif:LXCXE motif,splice variant, Q16720 ATPase plasma membrane Ca2+ transporting 3(ATP2B3) Homo sapiens GO:0006810~transport,GO:0006874~cellular calcium ion homeostasis,GO:0034220~ion transmembrane transport,GO:0070588~calcium ion transmembrane transport,GO:1903779~regulation of cardiac conduction, GO:0005794~Golgi apparatus,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane,GO:0043231~intracellular membrane-bounded organelle,GO:1903561~extracellular vesicle, GO:0005388~calcium-transporting ATPase activity,GO:0005516~calmodulin binding,GO:0005524~ATP binding,GO:0030165~PDZ domain binding,GO:0046872~metal ion binding, IPR001757:Cation-transporting P-type ATPase,IPR004014:Cation-transporting P-type ATPase, N-terminal,IPR006068:Cation-transporting P-type ATPase, C-terminal,IPR006408:Calcium-transporting P-type ATPase, subfamily IIB,IPR008250:P-type ATPase, A domain,IPR018303:P-type ATPase, phosphorylation site,IPR022141:Calcium transporting P-type ATPase, C-terminal, plasma membrane,IPR023214:HAD-like domain,IPR023298:P-type ATPase, transmembrane domain,IPR023299:P-type ATPase, cytoplasmic domain N, hsa04020:Calcium signaling pathway,hsa04022:cGMP-PKG signaling pathway,hsa04024:cAMP signaling pathway,hsa04261:Adrenergic signaling in cardiomyocytes,hsa04970:Salivary secretion,hsa04972:Pancreatic secretion, 302500~Spinocerebellar ataxia, X-linked 1, SM00831:SM00831, Alternative splicing,ATP-binding,Calcium,Calcium transport,Calmodulin-binding,Cell membrane,Coiled coil,Complete proteome,Disease mutation,Hydrolase,Ion transport,Magnesium,Membrane,Metal-binding,Neurodegeneration,Nucleotide-binding,Phosphoprotein,Polymorphism,Reference proteome,Signal,Transmembrane,Transmembrane helix,Transport, active site:4-aspartylphosphate intermediate,chain:Plasma membrane calcium-transporting ATPase 3,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Pro,metal ion-binding site:Magnesium,modified residue,region of interest:Calmodulin-binding subdomain A,region of interest:Calmodulin-binding subdomain B,sequence conflict,sequence variant,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q13535 ATR serine/threonine kinase(ATR) Homo sapiens h_atrbrcaPathway:Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility,h_g1Pathway:Cell Cycle: G1/S Check Point ,h_g2Pathway:Cell Cycle: G2/M Checkpoint,h_plk3Pathway:Regulation of cell cycle progression by Plk3, GO:0000077~DNA damage checkpoint,GO:0006260~DNA replication,GO:0006281~DNA repair,GO:0006974~cellular response to DNA damage stimulus,GO:0007049~cell cycle,GO:0007275~multicellular organism development,GO:0008156~negative regulation of DNA replication,GO:0018105~peptidyl-serine phosphorylation,GO:0032212~positive regulation of telomere maintenance via telomerase,GO:0034644~cellular response to UV,GO:0036297~interstrand cross-link repair,GO:0042493~response to drug,GO:0043517~positive regulation of DNA damage response, signal transduction by p53 class mediator,GO:0046777~protein autophosphorylation,GO:0070198~protein localization to chromosome, telomeric region,GO:0071480~cellular response to gamma radiation,GO:0090399~replicative senescence,GO:0097694~establishment of RNA localization to telomere,GO:0097695~establishment of macromolecular complex localization to telomere,GO:1900034~regulation of cellular response to heat,GO:1901796~regulation of signal transduction by p53 class mediator,GO:1904884~positive regulation of telomerase catalytic core complex assembly, GO:0000784~nuclear chromosome, telomeric region,GO:0005654~nucleoplasm,GO:0005694~chromosome,GO:0005794~Golgi apparatus,GO:0016605~PML body, GO:0003677~DNA binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0032405~MutLalpha complex binding,GO:0032407~MutSalpha complex binding, IPR000403:Phosphatidylinositol 3-/4-kinase, catalytic domain,IPR003151:PIK-related kinase, FAT,IPR003152:PIK-related kinase, FATC,IPR011009:Protein kinase-like domain,IPR011989:Armadillo-like helical,IPR011990:Tetratricopeptide-like helical,IPR012993:UME,IPR014009:PIK-related kinase,IPR016024:Armadillo-type fold,IPR018936:Phosphatidylinositol 3/4-kinase, conserved site,IPR021133:HEAT, type 2,IPR026683:Serine/threonine-protein kinase TOR/Smg1, hsa03460:Fanconi anemia pathway,hsa04110:Cell cycle,hsa04115:p53 signaling pathway,hsa05166:HTLV-I infection, 210600~Seckel syndrome 1,614564~Cutaneous telangiectasia and cancer syndrome, familial, SM00146:PI3Kc,SM00802:UME,SM01343:SM01343, Alternative splicing,ATP-binding,Chromosome,Complete proteome,Disease mutation,DNA damage,DNA repair,DNA-binding,Dwarfism,Kinase,Manganese,Mental retardation,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Serine/threonine-protein kinase,Transferase, chain:Serine/threonine-protein kinase ATR,domain:FAT,domain:FATC,domain:PI3K/PI4K,modified residue,mutagenesis site,repeat:HEAT 1,repeat:HEAT 2,sequence conflict,sequence variant,splice variant, Q54KA7 Arf guanyl-nucleotide exchange factor(secG) Dictyostelium discoideum AX4 GO:0006935~chemotaxis,GO:0030036~actin cytoskeleton organization,GO:0031154~culmination involved in sorocarp development,GO:0031589~cell-substrate adhesion,GO:0032012~regulation of ARF protein signal transduction,GO:0043327~chemotaxis to cAMP,GO:0072661~protein targeting to plasma membrane, GO:0005764~lysosome,GO:0005829~cytosol, GO:0005086~ARF guanyl-nucleotide exchange factor activity,GO:0008093~cytoskeletal adaptor activity,GO:0030507~spectrin binding, IPR000904:SEC7-like,IPR001849:Pleckstrin homology domain,IPR002110:Ankyrin repeat,IPR011993:Pleckstrin homology-like domain,IPR020683:Ankyrin repeat-containing domain,IPR023394:SEC7-like, alpha orthogonal bundle, ddi04144:Endocytosis, SM00222:Sec7,SM00233:PH,SM00248:ANK, ANK repeat,Complete proteome,Reference proteome,Repeat, Q8K2K6 ArfGAP with FG repeats 1(Agfg1) Mus musculus GO:0001675~acrosome assembly,GO:0006810~transport,GO:0007275~multicellular organism development,GO:0007283~spermatogenesis,GO:0007289~spermatid nucleus differentiation,GO:0030154~cell differentiation,GO:0045109~intermediate filament organization, GO:0005634~nucleus,GO:0016023~cytoplasmic, membrane-bounded vesicle,GO:0031410~cytoplasmic vesicle,GO:0042995~cell projection,GO:0043025~neuronal cell body,GO:0043231~intracellular membrane-bounded organelle, GO:0003677~DNA binding,GO:0005096~GTPase activator activity,GO:0046872~metal ion binding, IPR001164:Arf GTPase activating protein, mmu05164:Influenza A, SM00105:ArfGap, Alternative splicing,Complete proteome,Cytoplasmic vesicle,Developmental protein,Differentiation,DNA-binding,Glycoprotein,Metal-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Spermatogenesis,Transport,Zinc,Zinc-finger, chain:Arf-GAP domain and FG repeats-containing protein 1,domain:Arf-GAP,glycosylation site:O-linked (GlcNAc),modified residue,sequence conflict,splice variant,zinc finger region:C4-type, Q9H6U6 BCAS3, microtubule associated cell migration factor(BCAS3) Homo sapiens GO:0001525~angiogenesis,GO:0006351~transcription, DNA-templated,GO:0007030~Golgi organization,GO:0010595~positive regulation of endothelial cell migration,GO:0016192~vesicle-mediated transport,GO:0031023~microtubule organizing center organization,GO:0034260~negative regulation of GTPase activity,GO:0035148~tube formation,GO:0042594~response to starvation,GO:0043085~positive regulation of catalytic activity,GO:0043547~positive regulation of GTPase activity,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0051491~positive regulation of filopodium assembly,GO:0051895~negative regulation of focal adhesion assembly,GO:0071391~cellular response to estrogen stimulus,GO:0090316~positive regulation of intracellular protein transport,GO:0090630~activation of GTPase activity,GO:2000114~regulation of establishment of cell polarity,GO:2000251~positive regulation of actin cytoskeleton reorganization, GO:0005634~nucleus,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005881~cytoplasmic microtubule,GO:0031252~cell leading edge,GO:0035327~transcriptionally active chromatin,GO:0045111~intermediate filament cytoskeleton,GO:0071944~cell periphery, GO:0003682~chromatin binding,GO:0005515~protein binding,GO:0008134~transcription factor binding,GO:0010698~acetyltransferase activator activity,GO:0035035~histone acetyltransferase binding,GO:0035257~nuclear hormone receptor binding,GO:0042393~histone binding,GO:0048487~beta-tubulin binding, IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR022175:Breast carcinoma amplified sequence 3, Acetylation,Alternative splicing,Angiogenesis,Chromosomal rearrangement,Complete proteome,Cytoplasm,Cytoskeleton,Isopeptide bond,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Proto-oncogene,Reference proteome,Repeat,Transcription,Transcription regulation,Ubl conjugation,WD repeat, chain:Breast carcinoma-amplified sequence 3,modified residue,repeat:WD 1,repeat:WD 2,repeat:WD 3,sequence conflict,sequence variant,site:Breakpoint for translocation to form BCAS4-BCAS3,splice variant, Q66JB6 BRCA1 associated protein 1(bap1) Xenopus tropicalis GO:0001558~regulation of cell growth,GO:0006511~ubiquitin-dependent protein catabolic process,GO:0007219~Notch signaling pathway,GO:0016579~protein deubiquitination,GO:0035522~monoubiquitinated histone H2A deubiquitination,GO:0051726~regulation of cell cycle,GO:0071108~protein K48-linked deubiquitination, GO:0005622~intracellular,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0035517~PR-DUB complex, GO:0003682~chromatin binding,GO:0004843~thiol-dependent ubiquitin-specific protease activity, IPR001578:Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1, Chromatin regulator,Complete proteome,Cytoplasm,Hydrolase,Nucleus,Protease,Reference proteome,Thiol protease,Ubl conjugation pathway, Q864U1 BRCA1, DNA repair associated(BRCA1) Bos taurus GO:0000724~double-strand break repair via homologous recombination,GO:0006260~DNA replication,GO:0006281~DNA repair,GO:0006301~postreplication repair,GO:0006349~regulation of gene expression by genetic imprinting,GO:0006351~transcription, DNA-templated,GO:0006633~fatty acid biosynthetic process,GO:0007049~cell cycle,GO:0007059~chromosome segregation,GO:0007098~centrosome cycle,GO:0008630~intrinsic apoptotic signaling pathway in response to DNA damage,GO:0009048~dosage compensation by inactivation of X chromosome,GO:0010212~response to ionizing radiation,GO:0010575~positive regulation of vascular endothelial growth factor production,GO:0031052~chromosome breakage,GO:0031398~positive regulation of protein ubiquitination,GO:0031572~G2 DNA damage checkpoint,GO:0033147~negative regulation of intracellular estrogen receptor signaling pathway,GO:0035066~positive regulation of histone acetylation,GO:0035067~negative regulation of histone acetylation,GO:0043009~chordate embryonic development,GO:0043627~response to estrogen,GO:0044030~regulation of DNA methylation,GO:0045717~negative regulation of fatty acid biosynthetic process,GO:0045739~positive regulation of DNA repair,GO:0045766~positive regulation of angiogenesis,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0051571~positive regulation of histone H3-K4 methylation,GO:0051572~negative regulation of histone H3-K4 methylation,GO:0051573~negative regulation of histone H3-K9 methylation,GO:0051574~positive regulation of histone H3-K9 methylation,GO:0051865~protein autoubiquitination,GO:0070512~positive regulation of histone H4-K20 methylation,GO:0071158~positive regulation of cell cycle arrest,GO:0071356~cellular response to tumor necrosis factor,GO:0071681~cellular response to indole-3-methanol,GO:0085020~protein K6-linked ubiquitination,GO:1902042~negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,GO:2000378~negative regulation of reactive oxygen species metabolic process,GO:2000617~positive regulation of histone H3-K9 acetylation,GO:2000620~positive regulation of histone H4-K16 acetylation, GO:0000794~condensed nuclear chromosome,GO:0005634~nucleus,GO:0005694~chromosome,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0030529~intracellular ribonucleoprotein complex,GO:0031436~BRCA1-BARD1 complex,GO:0070531~BRCA1-A complex, GO:0003677~DNA binding,GO:0003684~damaged DNA binding,GO:0003723~RNA binding,GO:0004842~ubiquitin-protein transferase activity,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0044212~transcription regulatory region DNA binding, IPR001357:BRCT domain,IPR001841:Zinc finger, RING-type,IPR011364:Breast cancer type 1 susceptibility protein (BRCA1),IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR017907:Zinc finger, RING-type, conserved site,IPR018957:Zinc finger, C3HC4 RING-type,IPR025994:BRCA1, serine-rich domain, bta03460:Fanconi anemia pathway,bta04120:Ubiquitin mediated proteolysis,bta04151:PI3K-Akt signaling pathway,bta05206:MicroRNAs in cancer, PIRSF001734:transcriptional regulator, BRCA1 type, SM00184:RING,SM00292:BRCT, Acetylation,Activator,Cell cycle,Chromosome,Coiled coil,Complete proteome,Cytoplasm,DNA damage,DNA recombination,DNA repair,DNA-binding,Fatty acid biosynthesis,Fatty acid metabolism,Isopeptide bond,Ligase,Lipid biosynthesis,Lipid metabolism,Metal-binding,Nucleus,Phosphoprotein,Reference proteome,Repeat,Transcription,Transcription regulation,Transferase,Tumor suppressor,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, chain:Breast cancer type 1 susceptibility protein homolog,domain:BRCT 1,domain:BRCT 2,modified residue,zinc finger region:RING-type, Q9LYL9 BTB/POZ domain-containing protein(AT3G56230) Arabidopsis thaliana GO:0030162~regulation of proteolysis,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process,GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0019005~SCF ubiquitin ligase complex, GO:0031625~ubiquitin protein ligase binding, IPR000210:BTB/POZ-like,IPR011333:BTB/POZ fold, SM00225:BTB, Complete proteome,Reference proteome,Ubl conjugation pathway, Q9Z1S0 BUB1B, mitotic checkpoint serine/threonine kinase(Bub1b) Mus musculus Signal transduction mechanisms, GO:0006468~protein phosphorylation,GO:0006915~apoptotic process,GO:0007049~cell cycle,GO:0007067~mitotic nuclear division,GO:0007091~metaphase/anaphase transition of mitotic cell cycle,GO:0007094~mitotic spindle assembly checkpoint,GO:0016310~phosphorylation,GO:0034501~protein localization to kinetochore,GO:0051301~cell division,GO:0071459~protein localization to chromosome, centromeric region, GO:0000775~chromosome, centromeric region,GO:0000776~kinetochore,GO:0000777~condensed chromosome kinetochore,GO:0000778~condensed nuclear chromosome kinetochore,GO:0000940~condensed chromosome outer kinetochore,GO:0005634~nucleus,GO:0005694~chromosome,GO:0005737~cytoplasm,GO:0048471~perinuclear region of cytoplasm, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0016740~transferase activity, IPR000719:Protein kinase, catalytic domain,IPR011009:Protein kinase-like domain,IPR013212:Mad3/BUB1 homology region 1,IPR015661:Mitotic checkpoint serine/threonine protein kinase Bub1/Mitotic spindle checkpoint component Mad3, mmu04110:Cell cycle,mmu05166:HTLV-I infection, SM00777:Mad3_BUB1_I, Acetylation,Apoptosis,ATP-binding,Cell cycle,Cell division,Centromere,Chromosome,Coiled coil,Complete proteome,Cytoplasm,Kinase,Kinetochore,Mitosis,Nucleotide-binding,Nucleus,Phosphoprotein,Reference proteome,Serine/threonine-protein kinase,Transferase,Tumor suppressor,Ubl conjugation, active site:Proton acceptor,binding site:ATP,chain:Mitotic checkpoint serine/threonine- protein kinase BUB1 beta,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Ser,domain:CD1,domain:Protein kinase,modified residue,nucleotide phosphate-binding region:ATP,region of interest:Necessary for interaction with CASC5,short sequence motif:D-box,short sequence motif:Nuclear localization signal,site:Cleavage; by caspase-3, Q99PU7 Brca1 associated protein 1(Bap1) Mus musculus GO:0001558~regulation of cell growth,GO:0006508~proteolysis,GO:0006511~ubiquitin-dependent protein catabolic process,GO:0008285~negative regulation of cell proliferation,GO:0010035~response to inorganic substance,GO:0016569~covalent chromatin modification,GO:0016579~protein deubiquitination,GO:0035520~monoubiquitinated protein deubiquitination,GO:0035522~monoubiquitinated histone H2A deubiquitination,GO:0050727~regulation of inflammatory response,GO:0051726~regulation of cell cycle,GO:0061519~macrophage homeostasis,GO:0071108~protein K48-linked deubiquitination,GO:1900015~regulation of cytokine production involved in inflammatory response,GO:1903955~positive regulation of protein targeting to mitochondrion, GO:0005622~intracellular,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0016021~integral component of membrane,GO:0035517~PR-DUB complex, GO:0003682~chromatin binding,GO:0004843~thiol-dependent ubiquitin-specific protease activity,GO:0005515~protein binding,GO:0008233~peptidase activity,GO:0008234~cysteine-type peptidase activity,GO:0016787~hydrolase activity,GO:0036459~thiol-dependent ubiquitinyl hydrolase activity, IPR001578:Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1, Chromatin regulator,Coiled coil,Complete proteome,Cytoplasm,Hydrolase,Membrane,Nucleus,Phosphoprotein,Protease,Proteomics identification,Reference proteome,Thiol protease,Transmembrane,Transmembrane helix,Ubl conjugation,Ubl conjugation pathway, chain:Ubiquitin carboxyl-terminal hydrolase BAP1,modified residue,region of interest:Interaction with BRCA1,sequence conflict, Q9ESN4 C1q-like 3(C1ql3) Mus musculus GO:0050807~regulation of synapse organization, GO:0005576~extracellular region,GO:0005581~collagen trimer, GO:0005515~protein binding, IPR001073:Complement C1q protein,IPR008160:Collagen triple helix repeat,IPR008983:Tumour necrosis factor-like domain, SM00110:C1Q, 3D-structure,Collagen,Complete proteome,Reference proteome,Secreted,Signal, chain:Complement C1q-like protein 3,domain:C1q,domain:Collagen-like,signal peptide, P30622 CAP-Gly domain containing linker protein 1(CLIP1) Homo sapiens h_Lis1Pathway:Lissencephaly gene (LIS1) in neuronal migration and development, GO:0001578~microtubule bundle formation,GO:0007062~sister chromatid cohesion,GO:0007067~mitotic nuclear division,GO:0031116~positive regulation of microtubule polymerization,GO:0044861~protein transport into plasma membrane raft,GO:1900006~positive regulation of dendrite development, GO:0000776~kinetochore,GO:0001726~ruffle,GO:0005635~nuclear envelope,GO:0005737~cytoplasm,GO:0005768~endosome,GO:0005813~centrosome,GO:0005829~cytosol,GO:0005874~microtubule,GO:0005881~cytoplasmic microtubule,GO:0005882~intermediate filament,GO:0015630~microtubule cytoskeleton,GO:0030659~cytoplasmic vesicle membrane,GO:0035371~microtubule plus-end,GO:0044354~macropinosome,GO:1990752~microtubule end, GO:0003676~nucleic acid binding,GO:0005515~protein binding,GO:0008017~microtubule binding,GO:0008270~zinc ion binding,GO:0015631~tubulin binding,GO:0042803~protein homodimerization activity,GO:0046872~metal ion binding,GO:0051010~microtubule plus-end binding, IPR000938:CAP Gly-rich domain, SM01052:SM01052, 3D-structure,Alternative splicing,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Cytoskeleton,Membrane,Metal-binding,Microtubule,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Transport,Zinc,Zinc-finger, chain:CAP-Gly domain-containing linker protein 1,compositionally biased region:Ser-rich,domain:CAP-Gly 1,domain:CAP-Gly 2,helix,modified residue,sequence conflict,sequence variant,short sequence motif:CCHC-box,splice variant,strand,turn, Q5U243 CAP-Gly domain containing linker protein 3 S homeolog(clip3.S) Xenopus laevis GO:0005795~Golgi stack,GO:0005802~trans-Golgi network,GO:0005886~plasma membrane,GO:0010008~endosome membrane,GO:0045121~membrane raft, IPR000938:CAP Gly-rich domain,IPR002110:Ankyrin repeat,IPR020683:Ankyrin repeat-containing domain, SM00248:ANK,SM01052:SM01052, ANK repeat,Cytoplasm,Golgi apparatus,Repeat, chain:CAP-Gly domain-containing linker protein 3,domain:CAP-Gly 1,domain:CAP-Gly 2,region of interest:GoLD,repeat:ANK 1,repeat:ANK 2,repeat:ANK 3, P40240 CD9 antigen(Cd9) Mus musculus GO:0006928~movement of cell or subcellular component,GO:0007155~cell adhesion,GO:0007166~cell surface receptor signaling pathway,GO:0007338~single fertilization,GO:0007342~fusion of sperm to egg plasma membrane,GO:0007420~brain development,GO:0008285~negative regulation of cell proliferation,GO:0009414~response to water deprivation,GO:0014003~oligodendrocyte development,GO:0030913~paranodal junction assembly,GO:0031623~receptor internalization,GO:0071404~cellular response to low-density lipoprotein particle stimulus, GO:0005576~extracellular region,GO:0005615~extracellular space,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0005925~focal adhesion,GO:0009897~external side of plasma membrane,GO:0009986~cell surface,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0016324~apical plasma membrane,GO:0070062~extracellular exosome,GO:1903561~extracellular vesicle, GO:0005178~integrin binding,GO:0005515~protein binding, IPR000301:Tetraspanin,IPR008952:Tetraspanin, EC2 domain,IPR018499:Tetraspanin/Peripherin,IPR018503:Tetraspanin, conserved site, mmu04640:Hematopoietic cell lineage, PIRSF002419:tetraspanin, Cell adhesion,Cell membrane,Complete proteome,Disulfide bond,Fertilization,Glycoprotein,Lipoprotein,Membrane,Palmitate,Reference proteome,Secreted,Transmembrane,Transmembrane helix, chain:CD9 antigen,glycosylation site:N-linked (GlcNAc...),lipid moiety-binding region:S-palmitoyl cysteine,mutagenesis site,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q5VT25 CDC42 binding protein kinase alpha(CDC42BPA) Homo sapiens DNA replication, recombination, and repair,Function unknown, GO:0006468~protein phosphorylation,GO:0016477~cell migration,GO:0031032~actomyosin structure organization,GO:0031532~actin cytoskeleton reorganization,GO:0035556~intracellular signal transduction, GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0005911~cell-cell junction,GO:0031252~cell leading edge,GO:0042641~actomyosin,GO:0070062~extracellular exosome, GO:0000287~magnesium ion binding,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0042802~identical protein binding,GO:0046872~metal ion binding, IPR000095:PAK-box/P21-Rho-binding,IPR000719:Protein kinase, catalytic domain,IPR000961:AGC-kinase, C-terminal,IPR001180:Citron-like,IPR001849:Pleckstrin homology domain,IPR002219:Protein kinase C-like, phorbol ester/diacylglycerol binding,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR011993:Pleckstrin homology-like domain,IPR014930:Myotonic dystrophy protein kinase, coiled coil,IPR017441:Protein kinase, ATP binding site,IPR017892:Protein kinase, C-terminal,IPR020454:Diacylglycerol/phorbol-ester binding,IPR026611:Serine/threonine-protein kinase MRCK, SM00036:CNH,SM00109:C1,SM00133:S_TK_X,SM00220:S_TKc,SM00233:PH,SM00285:PBD, Alternative splicing,ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Kinase,Magnesium,Metal-binding,Nucleotide-binding,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Serine/threonine-protein kinase,Transferase,Zinc,Zinc-finger, active site:Proton acceptor,binding site:ATP,chain:Serine/threonine-protein kinase MRCK alpha,domain:AGC-kinase C-terminal,domain:CNH,domain:CRIB,domain:PH,domain:Protein kinase,modified residue,mutagenesis site,nucleotide phosphate-binding region:ATP,sequence conflict,sequence variant,splice variant,zinc finger region:Phorbol-ester/DAG-type, Q8K389 CDK5 regulatory subunit associated protein 2(Cdk5rap2) Mus musculus GO:0000132~establishment of mitotic spindle orientation,GO:0000226~microtubule cytoskeleton organization,GO:0001578~microtubule bundle formation,GO:0007059~chromosome segregation,GO:0007099~centriole replication,GO:0007420~brain development,GO:0022008~neurogenesis,GO:0031023~microtubule organizing center organization,GO:0045665~negative regulation of neuron differentiation,GO:0045893~positive regulation of transcription, DNA-templated,GO:0046600~negative regulation of centriole replication,GO:0051297~centrosome organization,GO:0090231~regulation of spindle checkpoint, GO:0000242~pericentriolar material,GO:0000922~spindle pole,GO:0005737~cytoplasm,GO:0005794~Golgi apparatus,GO:0005813~centrosome,GO:0005815~microtubule organizing center,GO:0005856~cytoskeleton,GO:0005874~microtubule,GO:0030054~cell junction,GO:0035371~microtubule plus-end,GO:0048471~perinuclear region of cytoplasm,GO:0070062~extracellular exosome,GO:0097431~mitotic spindle pole, GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0008017~microtubule binding,GO:0015631~tubulin binding,GO:0019901~protein kinase binding,GO:0032403~protein complex binding,GO:0044212~transcription regulatory region DNA binding, IPR012943:Spindle associated, Calmodulin-binding,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Golgi apparatus,Phosphoprotein,Proteomics identification,Reference proteome, chain:CDK5 regulatory subunit-associated protein 2,modified residue,region of interest:Interaction with CDK5R1, Q8IRG6 CG1828 gene product from transcript CG1828-RB(dre4) Drosophila melanogaster Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics, GO:0001672~regulation of chromatin assembly or disassembly,GO:0006260~DNA replication,GO:0006281~DNA repair,GO:0006351~transcription, DNA-templated,GO:0022008~neurogenesis,GO:0032968~positive regulation of transcription elongation from RNA polymerase II promoter, GO:0005634~nucleus,GO:0005694~chromosome,GO:0035101~FACT complex, GO:0003682~chromatin binding,GO:0031491~nucleosome binding, IPR000994:Peptidase M24, structural domain,IPR013719:Domain of unknown function DUF1747,IPR013953:FACT complex subunit Spt16p/Cdc68p, SM01285:SM01285,SM01286:SM01286,SM01287:SM01287, Alternative splicing,Chromosome,Coiled coil,Complete proteome,Direct protein sequencing,DNA damage,DNA repair,DNA replication,Nucleus,Phosphoprotein,Reference proteome,Transcription,Transcription regulation, chain:FACT complex subunit SPT16,compositionally biased region:Glu-rich (acidic),compositionally biased region:Ser-rich,modified residue,sequence conflict,splice variant, A8DYP0 CG33519 gene product from transcript CG33519-RH(Unc-89) Drosophila melanogaster GO:0006468~protein phosphorylation,GO:0007527~adult somatic muscle development,GO:0035023~regulation of Rho protein signal transduction,GO:0045214~sarcomere organization, GO:0031430~M band, GO:0004672~protein kinase activity,GO:0005089~Rho guanyl-nucleotide exchange factor activity,GO:0005524~ATP binding, IPR000219:Dbl homology (DH) domain,IPR000719:Protein kinase, catalytic domain,IPR001452:Src homology-3 domain,IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR003961:Fibronectin, type III,IPR007110:Immunoglobulin-like domain,IPR011009:Protein kinase-like domain,IPR011993:Pleckstrin homology-like domain,IPR013098:Immunoglobulin I-set,IPR013783:Immunoglobulin-like fold, SM00060:FN3,SM00325:RhoGEF,SM00408:IGc2,SM00409:IG, Coiled coil,Complete proteome,Proteomics identification,Reference proteome,Repeat, Q8I8U7 CG33554 gene product from transcript CG33554-RE(Nipped-A) Drosophila melanogaster GO:0000281~mitotic cytokinesis,GO:0006281~DNA repair,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006909~phagocytosis,GO:0016573~histone acetylation,GO:0035222~wing disc pattern formation,GO:0043486~histone exchange,GO:0043966~histone H3 acetylation,GO:0045747~positive regulation of Notch signaling pathway, GO:0000123~histone acetyltransferase complex,GO:0000124~SAGA complex,GO:0005634~nucleus,GO:0005700~polytene chromosome,GO:0005703~polytene chromosome puff,GO:0005737~cytoplasm,GO:0005875~microtubule associated complex,GO:0035267~NuA4 histone acetyltransferase complex, GO:0004402~histone acetyltransferase activity,GO:0016301~kinase activity, IPR000403:Phosphatidylinositol 3-/4-kinase, catalytic domain,IPR003151:PIK-related kinase, FAT,IPR003152:PIK-related kinase, FATC,IPR011009:Protein kinase-like domain,IPR011989:Armadillo-like helical,IPR011990:Tetratricopeptide-like helical,IPR014009:PIK-related kinase,IPR016024:Armadillo-type fold, SM00146:PI3Kc,SM01343:SM01343, Activator,Acyltransferase,Chromatin regulator,Complete proteome,Nucleus,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,Transferase, chain:Transcription-associated protein 1,domain:FAT,domain:FATC,domain:PI3K/PI4K,repeat:HEAT 1,repeat:HEAT 2,repeat:HEAT 3,repeat:HEAT 4,repeat:HEAT 5,repeat:HEAT 6,sequence conflict, Q9W596 CG34387 gene product from transcript CG34387-RF(futsch) Drosophila melanogaster GO:0000226~microtubule cytoskeleton organization,GO:0007017~microtubule-based process,GO:0007399~nervous system development,GO:0007409~axonogenesis,GO:0007528~neuromuscular junction development,GO:0008088~axo-dendritic transport,GO:0008355~olfactory learning,GO:0008582~regulation of synaptic growth at neuromuscular junction,GO:0043524~negative regulation of neuron apoptotic process,GO:0048749~compound eye development,GO:0048813~dendrite morphogenesis,GO:0060052~neurofilament cytoskeleton organization,GO:1901215~negative regulation of neuron death, GO:0005737~cytoplasm,GO:0005874~microtubule,GO:0005875~microtubule associated complex,GO:0015630~microtubule cytoskeleton,GO:0030424~axon,GO:0030425~dendrite,GO:0043025~neuronal cell body, GO:0005515~protein binding,GO:0008017~microtubule binding,GO:0019900~kinase binding, IPR001279:Beta-lactamase-like,IPR009603:Microtubule associated protein Futsch,IPR010918:AIR synthase-related protein, C-terminal domain,IPR026074:Microtubule associated protein 1, Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Developmental protein,Microtubule,Phosphoprotein,Proteomics identification,Reference proteome,Repeat, chain:Microtubule-associated protein futsch,modified residue,region of interest:53 X approximate repeat,repeat:1,repeat:10,repeat:11,repeat:12,repeat:13,repeat:14,repeat:15,repeat:16,repeat:17,repeat:18,repeat:19,repeat:2,repeat:20,repeat:21,repeat:22,repeat:23,repeat:24,repeat:25,repeat:26,repeat:27,repeat:28,repeat:29,repeat:3,repeat:30,repeat:31,repeat:32,repeat:33,repeat:34,repeat:35,repeat:36,repeat:37,repeat:38,repeat:39,repeat:4,repeat:40,repeat:41,repeat:42,repeat:43,repeat:44,repeat:45,repeat:46,repeat:47,repeat:48,repeat:49,repeat:5,repeat:50,repeat:51,repeat:52,repeat:53,repeat:6,repeat:7,repeat:8,repeat:9,sequence conflict, Q9VB74 CG6066 gene product from transcript CG6066-RA(CG6066) Drosophila melanogaster GO:0000398~mRNA splicing, via spliceosome,GO:0019233~sensory perception of pain,GO:0022008~neurogenesis, GO:0071013~catalytic step 2 spliceosome, IPR009269:Protein of unknown function DUF926, Complete proteome,Phosphoprotein,Reference proteome, chain:UPF0396 protein CG6066,compositionally biased region:Arg-rich,compositionally biased region:Lys-rich,compositionally biased region:Ser-rich,modified residue,sequence conflict, G5EBQ8 CHitin Synthase(chs-2) Caenorhabditis elegans GO:0000003~reproduction,GO:0002119~nematode larval development,GO:0006038~cell wall chitin biosynthetic process,GO:0008152~metabolic process,GO:0009792~embryo development ending in birth or egg hatching,GO:0010171~body morphogenesis,GO:0040007~growth,GO:0040011~locomotion, GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030428~cell septum,GO:0071944~cell periphery, GO:0004100~chitin synthase activity,GO:0016758~transferase activity, transferring hexosyl groups, IPR004835:Fungal chitin synthase, cel00520:Amino sugar and nucleotide sugar metabolism, Complete proteome,Membrane,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix, Q6IR75 COP9 signalosome subunit 2 L homeolog(cops2.L) Xenopus laevis Posttranslational modification, protein turnover, chaperones, GO:0005737~cytoplasm,GO:0008180~COP9 signalosome, IPR000717:Proteasome component (PCI) domain,IPR011990:Tetratricopeptide-like helical,IPR011991:Winged helix-turn-helix DNA-binding domain, SM00088:PINT, Cytoplasm,Nucleus,Signalosome, chain:COP9 signalosome complex subunit 2,domain:PCI, Q6PD62 CTR9 homolog, Paf1/RNA polymerase II complex component(CTR9) Homo sapiens General function prediction only, GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0001711~endodermal cell fate commitment,GO:0001826~inner cell mass cell differentiation,GO:0001829~trophectodermal cell differentiation,GO:0001832~blastocyst growth,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007259~JAK-STAT cascade,GO:0010390~histone monoubiquitination,GO:0016055~Wnt signaling pathway,GO:0016570~histone modification,GO:0019827~stem cell population maintenance,GO:0032968~positive regulation of transcription elongation from RNA polymerase II promoter,GO:0033523~histone H2B ubiquitination,GO:0045638~negative regulation of myeloid cell differentiation,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0051571~positive regulation of histone H3-K4 methylation,GO:0070102~interleukin-6-mediated signaling pathway,GO:0071222~cellular response to lipopolysaccharide,GO:0080182~histone H3-K4 trimethylation,GO:1900364~negative regulation of mRNA polyadenylation,GO:2000653~regulation of genetic imprinting,GO:2001162~positive regulation of histone H3-K79 methylation,GO:2001168~positive regulation of histone H2B ubiquitination, GO:0016593~Cdc73/Paf1 complex,GO:0016607~nuclear speck,GO:0035327~transcriptionally active chromatin, GO:0000993~RNA polymerase II core binding,GO:0005515~protein binding,GO:0042169~SH2 domain binding, IPR011990:Tetratricopeptide-like helical,IPR013026:Tetratricopeptide repeat-containing domain,IPR019734:Tetratricopeptide repeat, SM00028:TPR, Complete proteome,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,TPR repeat,Transcription,Transcription regulation,Wnt signaling pathway, chain:RNA polymerase-associated protein CTR9 homolog,compositionally biased region:Lys-rich,compositionally biased region:Poly-Gly,compositionally biased region:Poly-Lys,compositionally biased region:Ser-rich,modified residue,repeat:TPR 1,repeat:TPR 10,repeat:TPR 11,repeat:TPR 12,repeat:TPR 13,repeat:TPR 14,repeat:TPR 15,repeat:TPR 16,repeat:TPR 2,repeat:TPR 3,repeat:TPR 4,repeat:TPR 5,repeat:TPR 6,repeat:TPR 7,repeat:TPR 8,repeat:TPR 9, Q52KN9 CWC22 homolog, spliceosome-associated protein S homeolog(cwc22.S) Xenopus laevis GO:0006397~mRNA processing,GO:0008380~RNA splicing, GO:0005681~spliceosomal complex,GO:0016607~nuclear speck, GO:0003723~RNA binding, IPR003890:MIF4G-like, type 3,IPR003891:Initiation factor eIF-4 gamma, MA3,IPR016021:MIF4-like, type 1/2/3,IPR016024:Armadillo-type fold, SM00543:MIF4G,SM00544:MA3, mRNA processing,mRNA splicing,Nucleus, chain:Pre-mRNA-splicing factor CWC22 homolog,compositionally biased region:Arg-rich,compositionally biased region:Lys-rich,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Lys,compositionally biased region:Ser-rich,domain:MI,domain:MIF4G, Q3LSS0 CWF19-like 2, cell cycle control (S. pombe)(cwf19l2) Danio rerio GO:0003824~catalytic activity, IPR006767:Cwf19-like protein, C-terminal domain-2,IPR006768:Cwf19-like, C-terminal domain-1,IPR011146:HIT-like domain, Coiled coil,Complete proteome,Proteomics identification,Reference proteome, chain:CWF19-like protein 2,compositionally biased region:Lys-rich,compositionally biased region:Poly-Ser, Q66H62 CYLD lysine 63 deubiquitinase(Cyld) Rattus norvegicus GO:0006412~translation,GO:0006511~ubiquitin-dependent protein catabolic process,GO:0007346~regulation of mitotic cell cycle,GO:0010803~regulation of tumor necrosis factor-mediated signaling pathway,GO:0016055~Wnt signaling pathway,GO:0016579~protein deubiquitination,GO:0032088~negative regulation of NF-kappaB transcription factor activity,GO:0042347~negative regulation of NF-kappaB import into nucleus,GO:0043369~CD4-positive or CD8-positive, alpha-beta T cell lineage commitment,GO:0043393~regulation of protein binding,GO:0045087~innate immune response,GO:0045577~regulation of B cell differentiation,GO:0045581~negative regulation of T cell differentiation,GO:0045582~positive regulation of T cell differentiation,GO:0048872~homeostasis of number of cells,GO:0050862~positive regulation of T cell receptor signaling pathway,GO:0070266~necroptotic process,GO:0070507~regulation of microtubule cytoskeleton organization,GO:0070536~protein K63-linked deubiquitination,GO:0090090~negative regulation of canonical Wnt signaling pathway,GO:1901026~ripoptosome assembly involved in necroptotic process,GO:1902017~regulation of cilium assembly,GO:1903829~positive regulation of cellular protein localization,GO:1990108~protein linear deubiquitination,GO:2001238~positive regulation of extrinsic apoptotic signaling pathway,GO:2001242~regulation of intrinsic apoptotic signaling pathway, GO:0005813~centrosome,GO:0005819~spindle,GO:0005829~cytosol,GO:0005840~ribosome,GO:0005874~microtubule,GO:0005881~cytoplasmic microtubule,GO:0005886~plasma membrane,GO:0030496~midbody,GO:0031234~extrinsic component of cytoplasmic side of plasma membrane,GO:0036064~ciliary basal body,GO:0048471~perinuclear region of cytoplasm,GO:0097542~ciliary tip, GO:0003735~structural constituent of ribosome,GO:0004843~thiol-dependent ubiquitin-specific protease activity,GO:0008270~zinc ion binding,GO:0019901~protein kinase binding,GO:0061578~Lys63-specific deubiquitinase activity,GO:0070064~proline-rich region binding,GO:1990380~Lys48-specific deubiquitinase activity, IPR000938:CAP Gly-rich domain,IPR001394:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,IPR001593:Ribosomal protein S3Ae,IPR018200:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site,IPR027500:40S ribosomal protein S1/3, eukaryotes, rno04380:Osteoclast differentiation,rno04622:RIG-I-like receptor signaling pathway, SM01052:SM01052,SM01397:SM01397, Cell membrane,Cell projection,Complete proteome,Cytoplasm,Cytoskeleton,Hydrolase,Immunity,Innate immunity,Membrane,Metal-binding,Microtubule,Phosphoprotein,Protease,Reference proteome,Repeat,Ribonucleoprotein,Ribosomal protein,Thiol protease,Ubl conjugation pathway,Wnt signaling pathway,Zinc, chain:Probable ubiquitin carboxyl-terminal hydrolase CYLD,domain:CAP-Gly 1,domain:CAP-Gly 2,modified residue,region of interest:Interaction with NEMO,region of interest:Interaction with TRAF2,region of interest:Interaction with TRIP, Q9VXF1 Calcineurin A at 14F(CanA-14F) Drosophila melanogaster GO:0006470~protein dephosphorylation,GO:0030431~sleep,GO:0051533~positive regulation of NFAT protein import into nucleus, GO:0004721~phosphoprotein phosphatase activity,GO:0004722~protein serine/threonine phosphatase activity,GO:0016787~hydrolase activity,GO:0033192~calmodulin-dependent protein phosphatase activity,GO:0046872~metal ion binding, IPR004843:Metallophosphoesterase domain,IPR006186:Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase, dme04310:Wnt signaling pathway, SM00156:PP2Ac, Calcium,Calmodulin-binding,Complete proteome,Hydrolase,Iron,Metal-binding,Phosphoprotein,Protein phosphatase,Reference proteome,Zinc, Q5ZHZ4 Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1(CBLL1) Gallus gallus GO:0007162~negative regulation of cell adhesion,GO:0016567~protein ubiquitination,GO:0030155~regulation of cell adhesion,GO:0030335~positive regulation of cell migration,GO:0045807~positive regulation of endocytosis, GO:0003676~nucleic acid binding,GO:0004842~ubiquitin-protein transferase activity,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0042802~identical protein binding,GO:0061630~ubiquitin protein ligase activity, IPR001841:Zinc finger, RING-type,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR017907:Zinc finger, RING-type, conserved site, Complete proteome,Ligase,Metal-binding,Reference proteome,Ubl conjugation pathway,Zinc,Zinc-finger, chain:E3 ubiquitin-protein ligase Hakai,compositionally biased region:Pro-rich,zinc finger region:C2H2-type,zinc finger region:RING-type, Q9XWD6 Cell death abnormality protein 1(ced-1) Caenorhabditis elegans GO:0001845~phagolysosome assembly,GO:0006898~receptor-mediated endocytosis,GO:0006915~apoptotic process,GO:0006952~defense response,GO:0012501~programmed cell death,GO:0031532~actin cytoskeleton reorganization,GO:0034620~cellular response to unfolded protein,GO:0042742~defense response to bacterium,GO:0043652~engulfment of apoptotic cell,GO:0043654~recognition of apoptotic cell,GO:0045184~establishment of protein localization, GO:0001891~phagocytic cup,GO:0005886~plasma membrane,GO:0009986~cell surface,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030670~phagocytic vesicle membrane,GO:0031260~pseudopodium membrane,GO:0031410~cytoplasmic vesicle, GO:0005044~scavenger receptor activity,GO:0005515~protein binding, IPR000742:Epidermal growth factor-like domain,IPR002049:EGF-like, laminin,IPR006212:Furin-like repeat,IPR011489:EMI domain,IPR013032:EGF-like, conserved site, SM00180:EGF_Lam,SM00181:EGF,SM00261:FU, Alternative splicing,Apoptosis,Cell membrane,Complete proteome,Cytoplasmic vesicle,Disulfide bond,EGF-like domain,Glycoprotein,Membrane,Phosphoprotein,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Cell death abnormality protein 1,compositionally biased region:Poly-Ser,disulfide bond,domain:EGF-like 1,domain:EGF-like 2,domain:EGF-like 3,domain:EGF-like 4,domain:EGF-like 5,domain:EGF-like 6,domain:EMI,glycosylation site:N-linked (GlcNAc...),modified residue,mutagenesis site,repeat:FU,short sequence motif:NPXY,short sequence motif:YXXL,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q9UUE2 Centaurin 5(cnt5) Schizosaccharomyces pombe 972h- GO:0007264~small GTPase mediated signal transduction,GO:0043087~regulation of GTPase activity, GO:0005829~cytosol,GO:0005886~plasma membrane, GO:0005096~GTPase activator activity,GO:0005543~phospholipid binding,GO:0046872~metal ion binding, IPR001164:Arf GTPase activating protein,IPR001849:Pleckstrin homology domain,IPR011993:Pleckstrin homology-like domain,IPR027267:Arfaptin homology (AH) domain/BAR domain, spo04144:Endocytosis, SM00105:ArfGap,SM00233:PH, Complete proteome,GTPase activation,Metal-binding,Phosphoprotein,Reference proteome,Zinc,Zinc-finger, chain:Protein csx2,domain:Arf-GAP,domain:PH,modified residue,sequence conflict,zinc finger region:C4-type, Q9V3D2 Coproporphyrinogen oxidase(Coprox) Drosophila melanogaster GO:0006779~porphyrin-containing compound biosynthetic process,GO:0006782~protoporphyrinogen IX biosynthetic process,GO:0006783~heme biosynthetic process,GO:0055114~oxidation-reduction process, GO:0005739~mitochondrion, GO:0004109~coproporphyrinogen oxidase activity,GO:0042803~protein homodimerization activity, IPR001260:Coproporphyrinogen III oxidase, aerobic,IPR018375:Coproporphyrinogen III oxidase, conserved site, dme00860:Porphyrin and chlorophyll metabolism,dme01100:Metabolic pathways, PIRSF000166:coproporphyrinogen oxidase, Complete proteome,Heme biosynthesis,Oxidoreductase,Porphyrin biosynthesis,Reference proteome, active site:Proton donor,binding site:Substrate,chain:Coproporphyrinogen-III oxidase,region of interest:Important for dimerization,region of interest:Substrate binding,site:Important for dimerization, Q9VJE5 Cytoplasmic linker protein 190(CLIP-190) Drosophila melanogaster GO:0007017~microtubule-based process,GO:0007349~cellularization, GO:0000776~kinetochore,GO:0005794~Golgi apparatus,GO:0005875~microtubule associated complex,GO:0005876~spindle microtubule,GO:0005938~cell cortex,GO:0030424~axon,GO:0035371~microtubule plus-end,GO:0044295~axonal growth cone,GO:0045169~fusome, GO:0003779~actin binding,GO:0005515~protein binding,GO:0008017~microtubule binding,GO:0051010~microtubule plus-end binding,GO:0070854~myosin VI heavy chain binding, IPR000938:CAP Gly-rich domain, SM01052:SM01052, Actin-binding,Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Golgi apparatus,Microtubule,Phosphoprotein,Proteomics identification,Reference proteome,Repeat, chain:Restin homolog,compositionally biased region:Gln-rich,compositionally biased region:Glu-rich,domain:CAP-Gly 1,domain:CAP-Gly 2,modified residue,sequence conflict,splice variant, Q4R632 Cytosolic carboxypeptidase 2(AGBL2) Macaca fascicularis GO:0035610~protein side chain deglutamylation, GO:0005814~centriole,GO:0005829~cytosol,GO:0036064~ciliary basal body, GO:0004181~metallocarboxypeptidase activity,GO:0008270~zinc ion binding, IPR000834:Peptidase M14, carboxypeptidase A, Carboxypeptidase,Cell projection,Cytoplasm,Cytoskeleton,Hydrolase,Metal-binding,Metalloprotease,Protease,Zinc, Q8BMD2 DAZ interacting protein 1(Dzip1) Mus musculus GO:0007224~smoothened signaling pathway,GO:0007275~multicellular organism development,GO:0007283~spermatogenesis,GO:0030154~cell differentiation,GO:0042384~cilium assembly,GO:0045184~establishment of protein localization,GO:0051220~cytoplasmic sequestering of protein,GO:0060271~cilium morphogenesis, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005814~centriole,GO:0005815~microtubule organizing center,GO:0005856~cytoskeleton,GO:0005929~cilium,GO:0036064~ciliary basal body,GO:0042995~cell projection,GO:0097539~ciliary transition fiber, GO:0005515~protein binding,GO:0046872~metal ion binding, IPR007087:Zinc finger, C2H2,IPR015880:Zinc finger, C2H2-like, SM00355:ZnF_C2H2, Alternative splicing,Cell projection,Cilium,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Developmental protein,Differentiation,Metal-binding,Nucleus,Reference proteome,Spermatogenesis,Zinc,Zinc-finger, chain:Zinc finger protein DZIP1,sequence conflict,splice variant,zinc finger region:C2H2-type, Q86Y13 DAZ interacting zinc finger protein 3(DZIP3) Homo sapiens GO:0000209~protein polyubiquitination,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process,GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process, GO:0005737~cytoplasm, GO:0003723~RNA binding,GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0019902~phosphatase binding,GO:0031593~polyubiquitin binding,GO:0044822~poly(A) RNA binding,GO:0061630~ubiquitin protein ligase activity, IPR001841:Zinc finger, RING-type,IPR013083:Zinc finger, RING/FYVE/PHD-type, SM00184:RING, Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Ligase,Metal-binding,Proteomics identification,Reference proteome,RNA-binding,Ubl conjugation pathway,Zinc,Zinc-finger, chain:E3 ubiquitin-protein ligase DZIP3,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Lys,compositionally biased region:Poly-Pro,mutagenesis site,sequence conflict,splice variant,zinc finger region:RING-type; atypical, Q99MU0 DBF4 zinc finger(Dbf4) Cricetulus griseus GO:0006260~DNA replication,GO:0007049~cell cycle, GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0008270~zinc ion binding, IPR001357:BRCT domain,IPR006572:Zinc finger, DBF-type, cge04110:Cell cycle, SM00586:ZnF_DBF, Cell cycle,DNA replication,Metal-binding,Nucleus,Phosphoprotein,Repeat,Zinc,Zinc-finger, Q9Y4B6 DDB1 and CUL4 associated factor 1(DCAF1) Homo sapiens GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0006351~transcription, DNA-templated,GO:0016032~viral process,GO:0016567~protein ubiquitination,GO:0030183~B cell differentiation,GO:0033151~V(D)J recombination,GO:0035212~cell competition in a multicellular organism,GO:1990245~histone H2A-T120 phosphorylation, GO:0005634~nucleus,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0008180~COP9 signalosome, GO:0005515~protein binding,GO:0005524~ATP binding,GO:1990244~histone kinase activity (H2A-T120 specific), IPR006594:LisH dimerisation motif,IPR011989:Armadillo-like helical,IPR015943:WD40/YVTN repeat-like-containing domain,IPR016024:Armadillo-type fold,IPR017986:WD40-repeat-containing domain, SM00667:LisH, 3D-structure,Acetylation,Alternative splicing,ATP-binding,Chromatin regulator,Complete proteome,Cytoplasm,Direct protein sequencing,Host-virus interaction,Isopeptide bond,Kinase,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Reference proteome,Repeat,Serine/threonine-protein kinase,Transcription,Transcription regulation,Transferase,Ubl conjugation pathway,WD repeat, chain:Protein VPRBP,compositionally biased region:Asp/Glu-rich (acidic),cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),domain:LisH,modified residue,region of interest:WD repeat-like region,sequence variant,splice variant, Q5F485 DEAD (Asp-Glu-Ala-Asp) box helicase 42(DDX42) Gallus gallus GO:0008104~protein localization,GO:0010501~RNA secondary structure unwinding, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0016020~membrane, GO:0003723~RNA binding,GO:0004004~ATP-dependent RNA helicase activity,GO:0005524~ATP binding,GO:0044822~poly(A) RNA binding, IPR000629:RNA helicase, ATP-dependent, DEAD-box, conserved site,IPR001650:Helicase, C-terminal,IPR011545:DNA/RNA helicase, DEAD/DEAH box type, N-terminal,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR014014:RNA helicase, DEAD-box type, Q motif,IPR027417:P-loop containing nucleoside triphosphate hydrolase, gga03040:Spliceosome, SM00487:DEXDc,SM00490:HELICc, ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Helicase,Hydrolase,Nucleotide-binding,Nucleus,Reference proteome,RNA-binding, chain:ATP-dependent RNA helicase DDX42,compositionally biased region:Gly-rich,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Gly,domain:Helicase ATP-binding,domain:Helicase C-terminal,nucleotide phosphate-binding region:ATP,short sequence motif:DEAD box,short sequence motif:Q motif, Q7L014 DEAD-box helicase 46(DDX46) Homo sapiens GO:0000398~mRNA splicing, via spliceosome,GO:0010468~regulation of gene expression,GO:0010501~RNA secondary structure unwinding, GO:0005634~nucleus,GO:0015030~Cajal body,GO:0016020~membrane,GO:0016607~nuclear speck, GO:0003676~nucleic acid binding,GO:0004004~ATP-dependent RNA helicase activity,GO:0005524~ATP binding,GO:0044822~poly(A) RNA binding, IPR000629:RNA helicase, ATP-dependent, DEAD-box, conserved site,IPR001650:Helicase, C-terminal,IPR011545:DNA/RNA helicase, DEAD/DEAH box type, N-terminal,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR014014:RNA helicase, DEAD-box type, Q motif,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa03040:Spliceosome, SM00487:DEXDc,SM00490:HELICc, Acetylation,ATP-binding,Coiled coil,Complete proteome,Helicase,Hydrolase,Isopeptide bond,Lipoprotein,Membrane,mRNA processing,mRNA splicing,Myristate,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,RNA-binding,Ubl conjugation, chain:Probable ATP-dependent RNA helicase DDX46,compositionally biased region:Arg-rich,compositionally biased region:Poly-Asp,domain:Helicase ATP-binding,domain:Helicase C-terminal,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,sequence variant,short sequence motif:DEAD box,short sequence motif:Q motif, O88450 DEAF1 transcription factor(Deaf1) Rattus norvegicus GO:0001662~behavioral fear response,GO:0001843~neural tube closure,GO:0006351~transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0006366~transcription from RNA polymerase II promoter,GO:0008542~visual learning,GO:0033599~regulation of mammary gland epithelial cell proliferation,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0048706~embryonic skeletal system development,GO:2000026~regulation of multicellular organismal development, GO:0005576~extracellular region,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005667~transcription factor complex,GO:0005730~nucleolus,GO:0005737~cytoplasm, GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0046872~metal ion binding, IPR000770:SAND domain,IPR002893:Zinc finger, MYND-type,IPR010919:SAND domain-like,IPR024119:Transcription factor DEAF-1, SM00258:SAND, Alternative splicing,Complete proteome,Developmental protein,DNA-binding,Metal-binding,Neurogenesis,Nucleus,Phosphoprotein,Reference proteome,Secreted,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Deformed epidermal autoregulatory factor 1 homolog,compositionally biased region:Ala-rich,compositionally biased region:Pro-rich,domain:SAND,modified residue,sequence conflict,short sequence motif:Nuclear localization signal,splice variant,zinc finger region:MYND-type, O35286 DEAH (Asp-Glu-Ala-His) box polypeptide 15(Dhx15) Mus musculus GO:0000398~mRNA splicing, via spliceosome,GO:0006397~mRNA processing,GO:0008380~RNA splicing,GO:0009636~response to toxic substance,GO:0043279~response to alkaloid, GO:0005634~nucleus,GO:0005681~spliceosomal complex,GO:0005689~U12-type spliceosomal complex,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0071008~U2-type post-mRNA release spliceosomal complex, GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0003725~double-stranded RNA binding,GO:0004004~ATP-dependent RNA helicase activity,GO:0004386~helicase activity,GO:0005524~ATP binding,GO:0008026~ATP-dependent helicase activity,GO:0016787~hydrolase activity,GO:0044822~poly(A) RNA binding, IPR001650:Helicase, C-terminal,IPR002464:DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site,IPR007502:Helicase-associated domain,IPR011545:DNA/RNA helicase, DEAD/DEAH box type, N-terminal,IPR011709:Domain of unknown function DUF1605,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, mmu03040:Spliceosome, SM00487:DEXDc,SM00490:HELICc,SM00847:SM00847, Acetylation,ATP-binding,Complete proteome,Helicase,Hydrolase,mRNA processing,mRNA splicing,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome, chain:Putative pre-mRNA-splicing factor ATP- dependent RNA helicase DHX15,compositionally biased region:Poly-Gln,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Pro,domain:Helicase ATP-binding,domain:Helicase C-terminal,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,short sequence motif:DEAH box, Q8VHK9 DEAH (Asp-Glu-Ala-His) box polypeptide 36(Dhx36) Mus musculus Defense mechanisms, GO:0001503~ossification,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006396~RNA processing,GO:0009615~response to virus,GO:0010501~RNA secondary structure unwinding,GO:0032206~positive regulation of telomere maintenance,GO:0043330~response to exogenous dsRNA,GO:0045944~positive regulation of transcription from RNA polymerase II promoter, GO:0000781~chromosome, telomeric region,GO:0005634~nucleus,GO:0005694~chromosome,GO:0005737~cytoplasm,GO:0070062~extracellular exosome, GO:0000166~nucleotide binding,GO:0001047~core promoter binding,GO:0002151~G-quadruplex RNA binding,GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003723~RNA binding,GO:0003725~double-stranded RNA binding,GO:0004004~ATP-dependent RNA helicase activity,GO:0004386~helicase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008026~ATP-dependent helicase activity,GO:0008094~DNA-dependent ATPase activity,GO:0016787~hydrolase activity,GO:0042826~histone deacetylase binding,GO:0044212~transcription regulatory region DNA binding,GO:0044822~poly(A) RNA binding,GO:0051880~G-quadruplex DNA binding, IPR001650:Helicase, C-terminal,IPR002464:DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site,IPR007502:Helicase-associated domain,IPR011545:DNA/RNA helicase, DEAD/DEAH box type, N-terminal,IPR011709:Domain of unknown function DUF1605,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, mmu03018:RNA degradation, SM00487:DEXDc,SM00490:HELICc,SM00847:SM00847, Acetylation,ATP-binding,Chromosome,Coiled coil,Complete proteome,Cytoplasm,DNA-binding,Helicase,Hydrolase,Nucleotide-binding,Nucleus,Phosphoprotein,Reference proteome,RNA-binding,Telomere,Transcription,Transcription regulation, chain:Probable ATP-dependent RNA helicase DHX36,compositionally biased region:Gly-rich,domain:Helicase ATP-binding,domain:Helicase C-terminal,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,short sequence motif:DEAH box, Q8IY37 DEAH-box helicase 37(DHX37) Homo sapiens GO:0006364~rRNA processing,GO:0006396~RNA processing, GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0005737~cytoplasm, GO:0003676~nucleic acid binding,GO:0004004~ATP-dependent RNA helicase activity,GO:0004386~helicase activity,GO:0005524~ATP binding,GO:0044822~poly(A) RNA binding, IPR001650:Helicase, C-terminal,IPR007502:Helicase-associated domain,IPR011545:DNA/RNA helicase, DEAD/DEAH box type, N-terminal,IPR011709:Domain of unknown function DUF1605,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00487:DEXDc,SM00490:HELICc,SM00847:SM00847, ATP-binding,Complete proteome,Helicase,Hydrolase,Nucleotide-binding,Polymorphism,Proteomics identification,Reference proteome, chain:Probable ATP-dependent RNA helicase DHX37,domain:Helicase ATP-binding,domain:Helicase C-terminal,nucleotide phosphate-binding region:ATP,sequence conflict,sequence variant,short sequence motif:DEAH box, Q6BNG2 DEHA2E22000p(DEHA2E22000g) Debaryomyces hansenii CBS767 GO:0000738~DNA catabolic process, exonucleolytic,GO:0006272~leading strand elongation,GO:0006284~base-excision repair,GO:0006297~nucleotide-excision repair, DNA gap filling,GO:0006303~double-strand break repair via nonhomologous end joining,GO:0007064~mitotic sister chromatid cohesion,GO:0031573~intra-S DNA damage checkpoint,GO:0033314~mitotic DNA replication checkpoint,GO:0035822~gene conversion,GO:0042276~error-prone translesion synthesis,GO:0045004~DNA replication proofreading,GO:0070868~heterochromatin organization involved in chromatin silencing, GO:0008622~epsilon DNA polymerase complex, GO:0000166~nucleotide binding,GO:0003690~double-stranded DNA binding,GO:0003697~single-stranded DNA binding,GO:0003887~DNA-directed DNA polymerase activity,GO:0008270~zinc ion binding,GO:0008310~single-stranded DNA 3'-5' exodeoxyribonuclease activity,GO:0051539~4 iron, 4 sulfur cluster binding, IPR006133:DNA-directed DNA polymerase, family B, exonuclease domain,IPR006134:DNA-directed DNA polymerase, family B, multifunctional domain,IPR006172:DNA-directed DNA polymerase, family B,IPR012337:Ribonuclease H-like domain,IPR013697:DNA polymerase epsilon, catalytic subunit A, C-terminal, dha00230:Purine metabolism,dha00240:Pyrimidine metabolism,dha01100:Metabolic pathways,dha03030:DNA replication,dha03410:Base excision repair,dha03420:Nucleotide excision repair, SM00486:POLBc,SM01159:SM01159, 4Fe-4S,Complete proteome,DNA replication,DNA-binding,DNA-directed DNA polymerase,Iron,Iron-sulfur,Metal-binding,Nucleotidyltransferase,Nucleus,Reference proteome,Transferase,Zinc,Zinc-finger, Q6P3S1 DENN domain containing 1B(DENND1B) Homo sapiens GO:0015031~protein transport,GO:0032456~endocytic recycling,GO:0035745~T-helper 2 cell cytokine production,GO:0043547~positive regulation of GTPase activity,GO:0050776~regulation of immune response,GO:0050852~T cell receptor signaling pathway, GO:0005829~cytosol,GO:0030136~clathrin-coated vesicle, GO:0017112~Rab guanyl-nucleotide exchange factor activity,GO:0017137~Rab GTPase binding, IPR001194:DENN domain,IPR005112:dDENN domain,IPR005113:uDENN domain, SM00799:DENN,SM00800:uDENN,SM00801:dDENN, 3D-structure,Alternative splicing,Asthma,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Guanine-nucleotide releasing factor,Phosphoprotein,Polymorphism,Protein transport,Proteomics identification,Reference proteome,Transport, chain:DENN domain-containing protein 1B,domain:dDENN,domain:DENN,domain:uDENN,sequence conflict,sequence variant,splice variant, A6QR44 DGCR8, microprocessor complex subunit(DGCR8) Bos taurus GO:0031053~primary miRNA processing,GO:0072091~regulation of stem cell proliferation,GO:0090502~RNA phosphodiester bond hydrolysis, endonucleolytic, GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0015630~microtubule cytoskeleton,GO:0070877~microprocessor complex, GO:0003725~double-stranded RNA binding,GO:0004525~ribonuclease III activity,GO:0020037~heme binding,GO:0042803~protein homodimerization activity,GO:0046872~metal ion binding,GO:0070878~primary miRNA binding, IPR001202:WW domain,IPR014720:Double-stranded RNA-binding-like domain, SM00358:DSRM,SM00456:WW, Complete proteome,Heme,Iron,Isopeptide bond,Metal-binding,Nucleus,Phosphoprotein,Reference proteome,Repeat,RNA-binding,Ubl conjugation, chain:Microprocessor complex subunit DGCR8,domain:DRBM 1,domain:DRBM 2,domain:WW,metal ion-binding site:Iron (heme axial ligand),modified residue,region of interest:Necessary for heme-binding and pri-miRNA processing,region of interest:Necessary for interaction with NCL,region of interest:Necessary for interaction with RNASEN,region of interest:Necessary for nuclear localization and retention, A7E300 DLC1 Rho GTPase activating protein(DLC1) Bos taurus GO:0006915~apoptotic process,GO:0006919~activation of cysteine-type endopeptidase activity involved in apoptotic process,GO:0007165~signal transduction,GO:0008285~negative regulation of cell proliferation,GO:0008360~regulation of cell shape,GO:0030336~negative regulation of cell migration,GO:0035023~regulation of Rho protein signal transduction,GO:0035024~negative regulation of Rho protein signal transduction,GO:0035307~positive regulation of protein dephosphorylation,GO:0043547~positive regulation of GTPase activity,GO:0051497~negative regulation of stress fiber assembly,GO:0051895~negative regulation of focal adhesion assembly,GO:1900119~positive regulation of execution phase of apoptosis, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005901~caveola,GO:0005925~focal adhesion,GO:0016020~membrane,GO:0030864~cortical actin cytoskeleton,GO:0032587~ruffle membrane, GO:0005096~GTPase activator activity,GO:0008289~lipid binding, IPR000198:Rho GTPase-activating protein domain,IPR001660:Sterile alpha motif domain,IPR002913:START domain,IPR008936:Rho GTPase activation protein,IPR013761:Sterile alpha motif/pointed domain,IPR023393:START-like domain, SM00234:START,SM00324:RhoGAP, Cell junction,Complete proteome,Cytoplasm,GTPase activation,Membrane,Phosphoprotein,Reference proteome,Tumor suppressor, chain:Rho GTPase-activating protein 7,compositionally biased region:Poly-Ser,compositionally biased region:Ser-rich,domain:Rho-GAP,domain:SAM,domain:START,modified residue, O75417 DNA polymerase theta(POLQ) Homo sapiens DNA replication, recombination, and repair, GO:0000724~double-strand break repair via homologous recombination,GO:0006261~DNA-dependent DNA replication,GO:0006281~DNA repair,GO:0006284~base-excision repair,GO:0006302~double-strand break repair,GO:0006974~cellular response to DNA damage stimulus,GO:0016446~somatic hypermutation of immunoglobulin genes,GO:0051260~protein homooligomerization,GO:0071897~DNA biosynthetic process,GO:0097681~double-strand break repair via alternative nonhomologous end joining,GO:2000042~negative regulation of double-strand break repair via homologous recombination, GO:0005654~nucleoplasm,GO:0005694~chromosome, GO:0003677~DNA binding,GO:0003682~chromatin binding,GO:0003684~damaged DNA binding,GO:0003887~DNA-directed DNA polymerase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0043142~single-stranded DNA-dependent ATPase activity,GO:0051575~5'-deoxyribose-5-phosphate lyase activity, IPR001098:DNA-directed DNA polymerase, family A, palm domain,IPR001650:Helicase, C-terminal,IPR002298:DNA polymerase A,IPR011545:DNA/RNA helicase, DEAD/DEAH box type, N-terminal,IPR012337:Ribonuclease H-like domain,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR019760:DNA-directed DNA polymerase, family A, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00482:POLAc,SM00487:DEXDc,SM00490:HELICc, 3D-structure,Acetylation,Alternative splicing,ATP-binding,Chromosome,Coiled coil,Complete proteome,DNA damage,DNA repair,DNA-directed DNA polymerase,Nucleotide-binding,Nucleotidyltransferase,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Transferase, Q9FFU6 DOMON domain-containing protein / dopamine beta-monooxygenase N-terminal domain-containing protein(AT5G54830) Arabidopsis thaliana GO:0055114~oxidation-reduction process, GO:0005768~endosome,GO:0005794~Golgi apparatus,GO:0005802~trans-Golgi network,GO:0016021~integral component of membrane, GO:0004497~monooxygenase activity,GO:0046872~metal ion binding, IPR005018:DOMON domain,IPR006593:Cytochrome b561/ferric reductase transmembrane,IPR019545:DM13 domain, SM00664:DoH,SM00665:B561,SM00686:DM13, Complete proteome,Electron transport,Heme,Iron,Membrane,Metal-binding,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix,Transport, Q8TDJ6 Dmx like 2(DMXL2) Homo sapiens GO:0007035~vacuolar acidification,GO:0070072~vacuolar proton-transporting V-type ATPase complex assembly, GO:0005615~extracellular space,GO:0008021~synaptic vesicle,GO:0030054~cell junction,GO:0030672~synaptic vesicle membrane,GO:0043291~RAVE complex, GO:0017137~Rab GTPase binding, IPR001680:WD40 repeat,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR022033:RAVE complex protein Rav1 C-terminal, 616113~Polyendocrine-polyneuropathy syndrome, SM00320:WD40, Alternative splicing,Cell junction,Coiled coil,Complete proteome,Cytoplasmic vesicle,Diabetes mellitus,Direct protein sequencing,Disease mutation,Hypogonadotropic hypogonadism,Membrane,Neuropathy,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Synapse,WD repeat, chain:DmX-like protein 2,modified residue,repeat:WD 1,repeat:WD 10,repeat:WD 11,repeat:WD 12,repeat:WD 13,repeat:WD 14,repeat:WD 15,repeat:WD 16,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,repeat:WD 8,repeat:WD 9,sequence conflict,sequence variant, Q61712 DnaJ heat shock protein family (Hsp40) member C1(Dnajc1) Mus musculus GO:0006417~regulation of translation,GO:0006457~protein folding,GO:0050708~regulation of protein secretion, GO:0005634~nucleus,GO:0005783~endoplasmic reticulum,GO:0005788~endoplasmic reticulum lumen,GO:0005789~endoplasmic reticulum membrane,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0031965~nuclear membrane,GO:0043231~intracellular membrane-bounded organelle, GO:0003677~DNA binding,GO:0005515~protein binding,GO:0043022~ribosome binding,GO:0051087~chaperone binding, IPR001005:SANT/Myb domain,IPR001623:DnaJ domain,IPR009057:Homeodomain-like,IPR017877:Myb-like domain,IPR017884:SANT domain,IPR018253:DnaJ domain, conserved site, mmu04141:Protein processing in endoplasmic reticulum, SM00271:DnaJ,SM00717:SANT, Chaperone,Coiled coil,Complete proteome,DNA-binding,Endoplasmic reticulum,Membrane,Microsome,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:DnaJ homolog subfamily C member 1,domain:J,domain:SANT 1,domain:SANT 2,modified residue,signal peptide,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, Q24133 DnaJ-like-1(DnaJ-1) Drosophila melanogaster GO:0006457~protein folding,GO:0009408~response to heat, GO:0005737~cytoplasm,GO:0005875~microtubule associated complex, GO:0051082~unfolded protein binding, IPR001623:DnaJ domain,IPR002939:Chaperone DnaJ, C-terminal,IPR008971:HSP40/DnaJ peptide-binding,IPR018253:DnaJ domain, conserved site, SM00271:DnaJ, Chaperone,Complete proteome,Cytoplasm,Phosphoprotein,Proteomics identification,Reference proteome,Stress response, chain:DnaJ protein homolog 1,domain:J,modified residue,sequence conflict, O35261 E2F transcription factor 3(E2f3) Mus musculus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007049~cell cycle,GO:0008284~positive regulation of cell proliferation,GO:0045893~positive regulation of transcription, DNA-templated,GO:0070345~negative regulation of fat cell proliferation, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005667~transcription factor complex,GO:0005737~cytoplasm, GO:0001047~core promoter binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0005515~protein binding,GO:0046983~protein dimerization activity, IPR003316:Transcription factor E2F/dimerisation partner (TDP),IPR011991:Winged helix-turn-helix DNA-binding domain,IPR015633:E2F Family, mmu04110:Cell cycle,mmu05161:Hepatitis B,mmu05166:HTLV-I infection,mmu05200:Pathways in cancer,mmu05206:MicroRNAs in cancer,mmu05212:Pancreatic cancer,mmu05214:Glioma,mmu05215:Prostate cancer,mmu05218:Melanoma,mmu05219:Bladder cancer,mmu05220:Chronic myeloid leukemia,mmu05222:Small cell lung cancer,mmu05223:Non-small cell lung cancer, SM01372:SM01372, Activator,Cell cycle,Coiled coil,Complete proteome,DNA-binding,Nucleus,Reference proteome,Transcription,Transcription regulation, chain:Transcription factor E2F3,compositionally biased region:Ala-rich,compositionally biased region:Poly-Gly,domain:Leucine-zipper,region of interest:Cyclin A/CDK2 binding,region of interest:Dimerization,region of interest:Retinoblastoma protein binding,region of interest:Transactivation,sequence conflict,short sequence motif:DEF box, Q6DE14 E2F transcription factor 4, p107/p130-binding S homeolog(e2f4.S) Xenopus laevis GO:0000278~mitotic cell cycle,GO:0006351~transcription, DNA-templated,GO:0044458~motile cilium assembly,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0098534~centriole assembly,GO:1903251~multi-ciliated epithelial cell differentiation, GO:0005634~nucleus,GO:0005667~transcription factor complex, GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding, IPR003316:Transcription factor E2F/dimerisation partner (TDP),IPR011991:Winged helix-turn-helix DNA-binding domain,IPR015633:E2F Family, xla04110:Cell cycle,xla04350:TGF-beta signaling pathway, SM01372:SM01372, Activator,Cilium biogenesis/degradation,DNA-binding,Nucleus,Transcription,Transcription regulation, F6YVB9 E2F transcription factor 7(e2f7) Xenopus tropicalis GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0001946~lymphangiogenesis,GO:0002040~sprouting angiogenesis,GO:0006351~transcription, DNA-templated,GO:0008285~negative regulation of cell proliferation,GO:0030330~DNA damage response, signal transduction by p53 class mediator,GO:0032466~negative regulation of cytokinesis,GO:0032877~positive regulation of DNA endoreduplication,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0060718~chorionic trophoblast cell differentiation,GO:0070365~hepatocyte differentiation,GO:0071930~negative regulation of transcription involved in G1/S transition of mitotic cell cycle,GO:2000134~negative regulation of G1/S transition of mitotic cell cycle, GO:0005634~nucleus,GO:0005667~transcription factor complex, GO:0001047~core promoter binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0003714~transcription corepressor activity, IPR003316:Transcription factor E2F/dimerisation partner (TDP),IPR011991:Winged helix-turn-helix DNA-binding domain,IPR015633:E2F Family, SM01372:SM01372, Activator,Cell cycle,Complete proteome,DNA-binding,Nucleus,Reference proteome,Repressor,Transcription,Transcription regulation, Q95LL8 EF-hand calcium binding domain 12(EFCAB12) Macaca fascicularis GO:0005509~calcium ion binding, IPR002048:EF-hand domain,IPR011992:EF-hand-like domain, Calcium,Metal-binding, Q8BGQ6 EF-hand calcium binding domain 14(Efcab14) Mus musculus Cell division and chromosome partitioning, GO:0016021~integral component of membrane, GO:0005509~calcium ion binding,GO:0046872~metal ion binding, IPR002048:EF-hand domain,IPR011992:EF-hand-like domain, Alternative splicing,Calcium,Complete proteome,Membrane,Metal-binding,Proteomics identification,Reference proteome,Repeat,Transmembrane,Transmembrane helix, chain:EF-hand domain-containing protein KIAA0494,domain:EF-hand 1,domain:EF-hand 2,modified residue,sequence conflict,splice variant, Q5THR3 EF-hand calcium binding domain 6(EFCAB6) Homo sapiens Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005634~nucleus, GO:0005509~calcium ion binding, IPR002048:EF-hand domain,IPR011992:EF-hand-like domain,IPR015070:EF-hand calcium-binding domain-containing protein 6,IPR018247:EF-Hand 1, calcium-binding site, SM00054:EFh, 3D-structure,Alternative splicing,Calcium,Complete proteome,Metal-binding,Nucleus,Phosphoprotein,Polymorphism,Reference proteome,Repeat,Repressor,Transcription,Transcription regulation, chain:EF-hand calcium-binding domain-containing protein 6,domain:EF-hand 1,domain:EF-hand 10,domain:EF-hand 11,domain:EF-hand 12,domain:EF-hand 13,domain:EF-hand 14,domain:EF-hand 15,domain:EF-hand 16,domain:EF-hand 17,domain:EF-hand 2,domain:EF-hand 3,domain:EF-hand 4,domain:EF-hand 5,domain:EF-hand 6,domain:EF-hand 7,domain:EF-hand 8,domain:EF-hand 9,helix,modified residue,region of interest:Interaction with AR,region of interest:Interaction with PARK7,sequence conflict,sequence variant,splice variant, Q9UUH0 ER lipid phosphatase (predicted)(SPAC630.12) Schizosaccharomyces pombe 972h- GO:0006506~GPI anchor biosynthetic process,GO:0006888~ER to Golgi vesicle-mediated transport, GO:0005783~endoplasmic reticulum,GO:0005789~endoplasmic reticulum membrane,GO:0016021~integral component of membrane, GO:0016787~hydrolase activity, IPR004843:Metallophosphoesterase domain, Complete proteome,Endoplasmic reticulum,Membrane,Reference proteome,Signal,Transmembrane,Transmembrane helix, chain:Uncharacterized protein C630.12,signal peptide,transmembrane region, Q5ZL00 ER membrane protein complex subunit 1(EMC1) Gallus gallus Function unknown, GO:0034975~protein folding in endoplasmic reticulum, GO:0016021~integral component of membrane,GO:0072546~ER membrane protein complex, IPR002372:Pyrrolo-quinoline quinone repeat,IPR011047:Quinonprotein alcohol dehydrogenase-like superfamily,IPR011678:Domain of unknown function DUF1620,IPR026895:ER membrane protein complex subunit 1,IPR027295:Quinonprotein alcohol dehydrogenase-like domain, Complete proteome,Glycoprotein,Membrane,Reference proteome,Signal,Transmembrane,Transmembrane helix, chain:Uncharacterized protein KIAA0090 homolog,domain:DUF1620,glycosylation site:N-linked (GlcNAc...),signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q6TGY8 ER membrane protein complex subunit 2(emc2) Danio rerio GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005783~endoplasmic reticulum,GO:0072546~ER membrane protein complex, IPR011990:Tetratricopeptide-like helical,IPR013026:Tetratricopeptide repeat-containing domain,IPR019734:Tetratricopeptide repeat, Complete proteome,Cytoplasm,Nucleus,Reference proteome,Repeat,TPR repeat, chain:Tetratricopeptide repeat protein 35,repeat:TPR 1,repeat:TPR 2,repeat:TPR 3, Q60HG1 ERCC excision repair 3, TFIIH core complex helicase subunit(ERCC3) Macaca fascicularis GO:0000717~nucleotide-excision repair, DNA duplex unwinding,GO:0006265~DNA topological change,GO:0006281~DNA repair,GO:0006283~transcription-coupled nucleotide-excision repair,GO:0006289~nucleotide-excision repair,GO:0006366~transcription from RNA polymerase II promoter,GO:0006367~transcription initiation from RNA polymerase II promoter,GO:0006468~protein phosphorylation,GO:0006915~apoptotic process,GO:0006979~response to oxidative stress,GO:0008104~protein localization,GO:0009411~response to UV,GO:0033683~nucleotide-excision repair, DNA incision,GO:0035315~hair cell differentiation,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:1901990~regulation of mitotic cell cycle phase transition, GO:0005675~holo TFIIH complex, GO:0003677~DNA binding,GO:0004003~ATP-dependent DNA helicase activity,GO:0005524~ATP binding,GO:0008022~protein C-terminus binding,GO:0016887~ATPase activity,GO:0043138~3'-5' DNA helicase activity,GO:0047485~protein N-terminus binding, IPR001161:Helicase Ercc3,IPR001650:Helicase, C-terminal,IPR006935:Helicase/UvrB domain,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, mcf03022:Basal transcription factors,mcf03420:Nucleotide excision repair, SM00487:DEXDc,SM00490:HELICc, ATP-binding,DNA damage,DNA repair,DNA-binding,Helicase,Hydrolase,Nucleotide-binding,Nucleus,Phosphoprotein,Transcription,Transcription regulation, Q03468 ERCC excision repair 6, chromatin remodeling factor(ERCC6) Homo sapiens GO:0000303~response to superoxide,GO:0006283~transcription-coupled nucleotide-excision repair,GO:0006284~base-excision repair,GO:0006290~pyrimidine dimer repair,GO:0006362~transcription elongation from RNA polymerase I promoter,GO:0006366~transcription from RNA polymerase II promoter,GO:0006979~response to oxidative stress,GO:0007256~activation of JNKK activity,GO:0007257~activation of JUN kinase activity,GO:0008630~intrinsic apoptotic signaling pathway in response to DNA damage,GO:0009411~response to UV,GO:0009636~response to toxic substance,GO:0010165~response to X-ray,GO:0010224~response to UV-B,GO:0010332~response to gamma radiation,GO:0032784~regulation of DNA-templated transcription, elongation,GO:0032786~positive regulation of DNA-templated transcription, elongation,GO:0035264~multicellular organism growth,GO:0045494~photoreceptor cell maintenance,GO:0045815~positive regulation of gene expression, epigenetic,GO:0061098~positive regulation of protein tyrosine kinase activity, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0008023~transcription elongation factor complex, GO:0003677~DNA binding,GO:0003678~DNA helicase activity,GO:0003682~chromatin binding,GO:0004386~helicase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008022~protein C-terminus binding,GO:0008094~DNA-dependent ATPase activity,GO:0030296~protein tyrosine kinase activator activity,GO:0032403~protein complex binding,GO:0047485~protein N-terminus binding, IPR000330:SNF2-related,IPR001650:Helicase, C-terminal,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa03420:Nucleotide excision repair, 133540~Cockayne syndrome, type B,211980~Lung cancer, susceptibility to,214150~Cerebrooculofacioskeletal syndrome 1,278800~De Sanctis-Cacchione syndrome,600630~UV-sensitive syndrome 1,613761~Macular degeneration, age-related, susceptibility to 5, SM00487:DEXDc,SM00490:HELICc, 3D-structure,Age-related macular degeneration,ATP-binding,Cataract,Cockayne syndrome,Complete proteome,Deafness,Disease mutation,DNA damage,DNA repair,DNA-binding,Dwarfism,Helicase,Hydrolase,Mental retardation,Methylation,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transcription,Transcription regulation,Ubl conjugation,Xeroderma pigmentosum, chain:DNA excision repair protein ERCC-6,compositionally biased region:Asp/Glu-rich (acidic),compositionally biased region:Gly-rich,domain:Helicase ATP-binding,domain:Helicase C-terminal,modified residue,nucleotide phosphate-binding region:ATP,sequence variant,short sequence motif:DEGH box,short sequence motif:Nuclear localization signal, Q9UF56 F-box and leucine rich repeat protein 17(FBXL17) Homo sapiens IPR001611:Leucine-rich repeat,IPR001810:F-box domain, cyclin-like,IPR006553:Leucine-rich repeat, cysteine-containing subtype, SM00256:FBOX,SM00367:LRR_CC, Alternative splicing,Complete proteome,Proteomics identification,Reference proteome,Ubl conjugation pathway, chain:F-box/LRR-repeat protein 17,compositionally biased region:Ala-rich,compositionally biased region:Gly-rich,compositionally biased region:Poly-Arg,compositionally biased region:Pro-rich,domain:F-box,splice variant, Q8N531 F-box and leucine rich repeat protein 6(FBXL6) Homo sapiens GO:0006508~proteolysis,GO:0016567~protein ubiquitination, GO:0004842~ubiquitin-protein transferase activity, IPR001611:Leucine-rich repeat,IPR001810:F-box domain, cyclin-like,IPR006553:Leucine-rich repeat, cysteine-containing subtype, SM00367:LRR_CC, Alternative splicing,Complete proteome,Leucine-rich repeat,Reference proteome,Repeat,Ubl conjugation pathway, chain:F-box/LRR-repeat protein 6,domain:F-box,repeat:LRR 1,repeat:LRR 2,repeat:LRR 3,splice variant, Q9QZN1 F-box and leucine-rich repeat protein 17(Fbxl17) Mus musculus IPR001611:Leucine-rich repeat,IPR001810:F-box domain, cyclin-like,IPR006553:Leucine-rich repeat, cysteine-containing subtype, SM00256:FBOX,SM00367:LRR_CC, Alternative splicing,Complete proteome,Proteomics identification,Reference proteome,Ubl conjugation pathway, chain:F-box/LRR-repeat protein 17,compositionally biased region:Ala-rich,compositionally biased region:Gly-rich,compositionally biased region:Poly-Arg,compositionally biased region:Poly-Pro,compositionally biased region:Pro-rich,domain:F-box,splice variant, Q8BH70 F-box and leucine-rich repeat protein 4(Fbxl4) Mus musculus GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0005758~mitochondrial intermembrane space, GO:0004842~ubiquitin-protein transferase activity, IPR001810:F-box domain, cyclin-like,IPR006553:Leucine-rich repeat, cysteine-containing subtype, SM00256:FBOX,SM00367:LRR_CC, Complete proteome,Cytoplasm,Leucine-rich repeat,Methylation,Mitochondrion,Nucleus,Proteomics identification,Reference proteome,Repeat,Ubl conjugation pathway, chain:F-box/LRR-repeat protein 4,domain:F-box,repeat:LRR 1,repeat:LRR 2,repeat:LRR 3,repeat:LRR 4,repeat:LRR 5,repeat:LRR 6,repeat:LRR 7,repeat:LRR 8, Q8C2S5 F-box and leucine-rich repeat protein 5(Fbxl5) Mus musculus GO:0016567~protein ubiquitination,GO:0031146~SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,GO:0055072~iron ion homeostasis,GO:1903364~positive regulation of cellular protein catabolic process, GO:0005737~cytoplasm,GO:0019005~SCF ubiquitin ligase complex,GO:0048471~perinuclear region of cytoplasm, GO:0005506~iron ion binding,GO:0046872~metal ion binding, IPR001611:Leucine-rich repeat,IPR001810:F-box domain, cyclin-like,IPR006553:Leucine-rich repeat, cysteine-containing subtype,IPR012312:Haemerythrin/HHE cation-binding motif, SM00256:FBOX,SM00367:LRR_CC, Alternative splicing,Complete proteome,Cytoplasm,Iron,Leucine-rich repeat,Metal-binding,Reference proteome,Repeat,Ubl conjugation,Ubl conjugation pathway, chain:F-box/LRR-repeat protein 5,domain:F-box,metal ion-binding site:Iron 1,metal ion-binding site:Iron 2,region of interest:Hemerythrin-like,repeat:LRR 1,repeat:LRR 2,repeat:LRR 3,repeat:LRR 4,sequence conflict,splice variant, Q5BJ29 F-box and leucine-rich repeat protein 7(Fbxl7) Mus musculus GO:0000086~G2/M transition of mitotic cell cycle,GO:0007049~cell cycle,GO:0007067~mitotic nuclear division,GO:0008283~cell proliferation,GO:0016567~protein ubiquitination,GO:0031146~SCF-dependent proteasomal ubiquitin-dependent protein catabolic process,GO:0051301~cell division, GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005856~cytoskeleton,GO:0016021~integral component of membrane,GO:0019005~SCF ubiquitin ligase complex, GO:0005515~protein binding, IPR001611:Leucine-rich repeat,IPR001810:F-box domain, cyclin-like,IPR006553:Leucine-rich repeat, cysteine-containing subtype, SM00256:FBOX,SM00367:LRR_CC, Cell cycle,Cell division,Complete proteome,Cytoplasm,Cytoskeleton,Leucine-rich repeat,Membrane,Mitosis,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Ubl conjugation pathway, chain:F-box/LRR-repeat protein 7,domain:F-box,repeat:LRR 1,repeat:LRR 10,repeat:LRR 2,repeat:LRR 3,repeat:LRR 4,repeat:LRR 5,repeat:LRR 6,repeat:LRR 7,repeat:LRR 8,repeat:LRR 9, Q5MNV8 F-box protein 47(FBXO47) Homo sapiens IPR001810:F-box domain, cyclin-like, Complete proteome,Polymorphism,Reference proteome,Ubl conjugation pathway, chain:F-box only protein 47,domain:F-box,sequence variant, Q14517 FAT atypical cadherin 1(FAT1) Homo sapiens GO:0007015~actin filament organization,GO:0007155~cell adhesion,GO:0007156~homophilic cell adhesion via plasma membrane adhesion molecules,GO:0007163~establishment or maintenance of cell polarity,GO:0007267~cell-cell signaling,GO:0009653~anatomical structure morphogenesis,GO:0016337~single organismal cell-cell adhesion,GO:0016477~cell migration, GO:0005634~nucleus,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0005911~cell-cell junction,GO:0005925~focal adhesion,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030027~lamellipodium,GO:0030175~filopodium,GO:0048471~perinuclear region of cytoplasm,GO:0070062~extracellular exosome, GO:0005509~calcium ion binding,GO:0005515~protein binding, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR001791:Laminin G domain,IPR001881:EGF-like calcium-binding,IPR002126:Cadherin,IPR013032:EGF-like, conserved site,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR015919:Cadherin-like,IPR018097:EGF-like calcium-binding, conserved site,IPR020894:Cadherin conserved site, SM00112:CA,SM00179:EGF_CA,SM00181:EGF,SM00282:LamG, Calcium,Cell adhesion,Cell membrane,Complete proteome,Cytoplasm,Disulfide bond,EGF-like domain,Glycoprotein,Membrane,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Protocadherin Fat 1,disulfide bond,domain:Cadherin 1,domain:Cadherin 10,domain:Cadherin 11,domain:Cadherin 12,domain:Cadherin 13,domain:Cadherin 14,domain:Cadherin 15,domain:Cadherin 16,domain:Cadherin 17,domain:Cadherin 18,domain:Cadherin 19,domain:Cadherin 2,domain:Cadherin 20,domain:Cadherin 21,domain:Cadherin 22,domain:Cadherin 23,domain:Cadherin 24,domain:Cadherin 25,domain:Cadherin 26,domain:Cadherin 27,domain:Cadherin 28,domain:Cadherin 29,domain:Cadherin 3,domain:Cadherin 30,domain:Cadherin 31,domain:Cadherin 32,domain:Cadherin 33,domain:Cadherin 34,domain:Cadherin 4,domain:Cadherin 5,domain:Cadherin 6,domain:Cadherin 7,domain:Cadherin 8,domain:Cadherin 9,domain:EGF-like 1,domain:EGF-like 2,domain:EGF-like 3,domain:EGF-like 4,domain:EGF-like 5,domain:Laminin G-like,glycosylation site:N-linked (GlcNAc...),modified residue,sequence variant,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q8TDW7 FAT atypical cadherin 3(FAT3) Homo sapiens GO:0007156~homophilic cell adhesion via plasma membrane adhesion molecules,GO:0007275~multicellular organism development, GO:0005886~plasma membrane,GO:0016021~integral component of membrane, GO:0005509~calcium ion binding, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR001791:Laminin G domain,IPR001881:EGF-like calcium-binding,IPR002126:Cadherin,IPR013032:EGF-like, conserved site,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR015919:Cadherin-like,IPR018097:EGF-like calcium-binding, conserved site,IPR020894:Cadherin conserved site, SM00112:CA,SM00179:EGF_CA,SM00181:EGF,SM00282:LamG, Alternative splicing,Calcium,Cell adhesion,Complete proteome,Developmental protein,Disulfide bond,EGF-like domain,Glycoprotein,Membrane,Methylation,Polymorphism,Proteomics identification,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Protocadherin Fat 3,compositionally biased region:Pro-rich,disulfide bond,domain:Cadherin 1,domain:Cadherin 10,domain:Cadherin 11,domain:Cadherin 12,domain:Cadherin 13,domain:Cadherin 14,domain:Cadherin 15,domain:Cadherin 16,domain:Cadherin 17,domain:Cadherin 18,domain:Cadherin 19,domain:Cadherin 2,domain:Cadherin 20,domain:Cadherin 21,domain:Cadherin 22,domain:Cadherin 23,domain:Cadherin 24,domain:Cadherin 25,domain:Cadherin 26,domain:Cadherin 27,domain:Cadherin 28,domain:Cadherin 29,domain:Cadherin 3,domain:Cadherin 30,domain:Cadherin 31,domain:Cadherin 32,domain:Cadherin 33,domain:Cadherin 4,domain:Cadherin 5,domain:Cadherin 6,domain:Cadherin 7,domain:Cadherin 8,domain:Cadherin 9,domain:EGF-like 1,domain:EGF-like 2,domain:EGF-like 3,domain:EGF-like 4; calcium-binding,domain:Laminin G-like,glycosylation site:N-linked (GlcNAc...),sequence variant,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q6V0I7 FAT atypical cadherin 4(FAT4) Homo sapiens GO:0001658~branching involved in ureteric bud morphogenesis,GO:0003007~heart morphogenesis,GO:0007009~plasma membrane organization,GO:0007156~homophilic cell adhesion via plasma membrane adhesion molecules,GO:0007157~heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,GO:0007219~Notch signaling pathway,GO:0008543~fibroblast growth factor receptor signaling pathway,GO:0021987~cerebral cortex development,GO:0022008~neurogenesis,GO:0035329~hippo signaling,GO:0043931~ossification involved in bone maturation,GO:0048565~digestive tract development,GO:0060122~inner ear receptor stereocilium organization,GO:0072137~condensed mesenchymal cell proliferation,GO:0072307~regulation of metanephric nephron tubule epithelial cell differentiation, GO:0005622~intracellular,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0045177~apical part of cell,GO:0070062~extracellular exosome, GO:0005509~calcium ion binding,GO:0005515~protein binding, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR001791:Laminin G domain,IPR001881:EGF-like calcium-binding,IPR002126:Cadherin,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR013032:EGF-like, conserved site,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR015919:Cadherin-like,IPR018097:EGF-like calcium-binding, conserved site,IPR020894:Cadherin conserved site, 615546~Van Maldergem syndrome 2,616006~Hennekam lymphangiectasia-lymphedema syndrome 2, SM00112:CA,SM00179:EGF_CA,SM00181:EGF,SM00282:LamG, Alternative splicing,Calcium,Cell adhesion,Complete proteome,Deafness,Disease mutation,Disulfide bond,EGF-like domain,Glycoprotein,Membrane,Mental retardation,Phosphoprotein,Polymorphism,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Protocadherin Fat 4,disulfide bond,domain:Cadherin 1,domain:Cadherin 10,domain:Cadherin 11,domain:Cadherin 12,domain:Cadherin 13,domain:Cadherin 14,domain:Cadherin 15,domain:Cadherin 16,domain:Cadherin 17,domain:Cadherin 18,domain:Cadherin 19,domain:Cadherin 2,domain:Cadherin 20,domain:Cadherin 21,domain:Cadherin 22,domain:Cadherin 23,domain:Cadherin 24,domain:Cadherin 25,domain:Cadherin 26,domain:Cadherin 27,domain:Cadherin 28,domain:Cadherin 29,domain:Cadherin 3,domain:Cadherin 30,domain:Cadherin 31,domain:Cadherin 32,domain:Cadherin 33,domain:Cadherin 34,domain:Cadherin 4,domain:Cadherin 5,domain:Cadherin 6,domain:Cadherin 7,domain:Cadherin 8,domain:Cadherin 9,domain:EGF-like 1,domain:EGF-like 2; calcium-binding,domain:EGF-like 3; calcium-binding,domain:EGF-like 4,domain:EGF-like 5,domain:EGF-like 6,domain:Laminin G-like 1,domain:Laminin G-like 2,glycosylation site:N-linked (GlcNAc...),modified residue,sequence conflict,sequence variant,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q2PZL6 FAT atypical cadherin 4(Fat4) Mus musculus GO:0001658~branching involved in ureteric bud morphogenesis,GO:0001736~establishment of planar polarity,GO:0001822~kidney development,GO:0003007~heart morphogenesis,GO:0007009~plasma membrane organization,GO:0007155~cell adhesion,GO:0007156~homophilic cell adhesion via plasma membrane adhesion molecules,GO:0007157~heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,GO:0007219~Notch signaling pathway,GO:0008543~fibroblast growth factor receptor signaling pathway,GO:0021987~cerebral cortex development,GO:0022008~neurogenesis,GO:0035329~hippo signaling,GO:0043931~ossification involved in bone maturation,GO:0048565~digestive tract development,GO:0060122~inner ear receptor stereocilium organization,GO:0072006~nephron development,GO:0072137~condensed mesenchymal cell proliferation,GO:0072307~regulation of metanephric nephron tubule epithelial cell differentiation, GO:0005622~intracellular,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0045177~apical part of cell,GO:0070062~extracellular exosome, GO:0005509~calcium ion binding,GO:0005515~protein binding, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR001791:Laminin G domain,IPR001881:EGF-like calcium-binding,IPR002126:Cadherin,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR013032:EGF-like, conserved site,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR015919:Cadherin-like,IPR018097:EGF-like calcium-binding, conserved site,IPR020894:Cadherin conserved site, SM00112:CA,SM00179:EGF_CA,SM00181:EGF,SM00282:LamG, Alternative splicing,Calcium,Cell adhesion,Complete proteome,Disulfide bond,EGF-like domain,Glycoprotein,Membrane,Phosphoprotein,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Protocadherin Fat 4,disulfide bond,domain:Cadherin 1,domain:Cadherin 10,domain:Cadherin 11,domain:Cadherin 12,domain:Cadherin 13,domain:Cadherin 14,domain:Cadherin 15,domain:Cadherin 16,domain:Cadherin 17,domain:Cadherin 18,domain:Cadherin 19,domain:Cadherin 2,domain:Cadherin 20,domain:Cadherin 21,domain:Cadherin 22,domain:Cadherin 23,domain:Cadherin 24,domain:Cadherin 25,domain:Cadherin 26,domain:Cadherin 27,domain:Cadherin 28,domain:Cadherin 29,domain:Cadherin 3,domain:Cadherin 30,domain:Cadherin 31,domain:Cadherin 32,domain:Cadherin 33,domain:Cadherin 34,domain:Cadherin 4,domain:Cadherin 5,domain:Cadherin 6,domain:Cadherin 7,domain:Cadherin 8,domain:Cadherin 9,domain:EGF-like 1,domain:EGF-like 2; calcium-binding,domain:EGF-like 3; calcium-binding,domain:EGF-like 4,domain:EGF-like 5,domain:EGF-like 6,domain:Laminin G-like 1,domain:Laminin G-like 2,glycosylation site:N-linked (GlcNAc...),modified residue,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q14CM0 FERM and PDZ domain containing 4(FRMPD4) Homo sapiens GO:0051835~positive regulation of synapse structural plasticity, GO:0005856~cytoskeleton,GO:0043197~dendritic spine, GO:0005515~protein binding,GO:0005546~phosphatidylinositol-4,5-bisphosphate binding, IPR000299:FERM domain,IPR001202:WW domain,IPR001478:PDZ domain,IPR011993:Pleckstrin homology-like domain,IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle,IPR019748:FERM central domain,IPR019749:Band 4.1 domain, SM00228:PDZ,SM00295:B41, 3D-structure,Cell projection,Complete proteome,Lipid-binding,Reference proteome, chain:FERM and PDZ domain-containing protein 4,domain:FERM,domain:PDZ,domain:WW,modified residue,mutagenesis site,sequence conflict, Q9P2Q2 FERM domain containing 4A(FRMD4A) Homo sapiens GO:0090162~establishment of epithelial cell polarity, GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005923~bicellular tight junction, GO:0030674~protein binding, bridging, IPR000299:FERM domain,IPR011993:Pleckstrin homology-like domain,IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle,IPR018979:FERM, N-terminal,IPR018980:FERM, C-terminal PH-like domain,IPR019747:FERM conserved site,IPR019748:FERM central domain,IPR019749:Band 4.1 domain,IPR021774:Protein of unknown function DUF3338, SM00295:B41,SM01196:SM01196, Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Mental retardation,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:FERM domain-containing protein 4A,compositionally biased region:Ser-rich,domain:FERM,modified residue,sequence conflict,sequence variant, Q8BIE6 FERM domain containing 4A(Frmd4a) Mus musculus GO:0090162~establishment of epithelial cell polarity, GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005923~bicellular tight junction, GO:0030674~protein binding, bridging, IPR000299:FERM domain,IPR011993:Pleckstrin homology-like domain,IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle,IPR018979:FERM, N-terminal,IPR018980:FERM, C-terminal PH-like domain,IPR019747:FERM conserved site,IPR019748:FERM central domain,IPR019749:Band 4.1 domain,IPR021774:Protein of unknown function DUF3338, SM00295:B41,SM01196:SM01196, Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Phosphoprotein,Proteomics identification,Reference proteome, chain:FERM domain-containing protein 4A,compositionally biased region:Ser-rich,domain:FERM,modified residue,sequence conflict,splice variant, O42123 FK506 binding protein 1A L homeolog(fkbp1a.L) Xenopus laevis GO:0000413~protein peptidyl-prolyl isomerization,GO:0001933~negative regulation of protein phosphorylation,GO:0003007~heart morphogenesis,GO:0006457~protein folding,GO:0006936~muscle contraction,GO:0007183~SMAD protein complex assembly,GO:0019221~cytokine-mediated signaling pathway,GO:0031000~response to caffeine,GO:0031398~positive regulation of protein ubiquitination,GO:0032092~positive regulation of protein binding,GO:0032513~negative regulation of protein phosphatase type 2B activity,GO:0032880~regulation of protein localization,GO:0032925~regulation of activin receptor signaling pathway,GO:0042098~T cell proliferation,GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling,GO:0043206~extracellular fibril organization,GO:0050776~regulation of immune response,GO:0051209~release of sequestered calcium ion into cytosol,GO:0051280~negative regulation of release of sequestered calcium ion into cytosol,GO:0055010~ventricular cardiac muscle tissue morphogenesis,GO:0060314~regulation of ryanodine-sensitive calcium-release channel activity,GO:0060315~negative regulation of ryanodine-sensitive calcium-release channel activity,GO:0060347~heart trabecula formation,GO:1902991~regulation of amyloid precursor protein catabolic process,GO:1990000~amyloid fibril formation, GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0014802~terminal cisterna,GO:0016020~membrane,GO:0030018~Z disc,GO:0031012~extracellular matrix,GO:0033017~sarcoplasmic reticulum membrane,GO:0070062~extracellular exosome, GO:0003755~peptidyl-prolyl cis-trans isomerase activity,GO:0004871~signal transducer activity,GO:0005528~FK506 binding,GO:0008144~drug binding,GO:0019855~calcium channel inhibitor activity,GO:0042803~protein homodimerization activity,GO:0044325~ion channel binding,GO:0046332~SMAD binding,GO:0048185~activin binding, IPR001179:Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain,IPR023566:Peptidyl-prolyl cis-trans isomerase, FKBP-type, Cytoplasm,Isomerase,Rotamase, chain:Peptidyl-prolyl cis-trans isomerase FKBP1A,domain:PPIase FKBP-type, Q14318 FK506 binding protein 8(FKBP8) Homo sapiens GO:0000413~protein peptidyl-prolyl isomerization,GO:0001708~cell fate specification,GO:0006457~protein folding,GO:0006915~apoptotic process,GO:0007224~smoothened signaling pathway,GO:0016032~viral process,GO:0021904~dorsal/ventral neural tube patterning,GO:0030513~positive regulation of BMP signaling pathway,GO:0035264~multicellular organism growth,GO:0035556~intracellular signal transduction,GO:0043010~camera-type eye development,GO:0043066~negative regulation of apoptotic process,GO:0061077~chaperone-mediated protein folding, GO:0005789~endoplasmic reticulum membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030176~integral component of endoplasmic reticulum membrane,GO:0031966~mitochondrial membrane, GO:0003755~peptidyl-prolyl cis-trans isomerase activity,GO:0005515~protein binding,GO:0005528~FK506 binding,GO:0042802~identical protein binding,GO:0046872~metal ion binding, IPR001179:Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain,IPR001440:Tetratricopeptide TPR-1,IPR011990:Tetratricopeptide-like helical,IPR013026:Tetratricopeptide repeat-containing domain,IPR013105:Tetratricopeptide TPR2,IPR019734:Tetratricopeptide repeat,IPR023114:Elongated TPR repeat-containing domain,IPR023566:Peptidyl-prolyl cis-trans isomerase, FKBP-type, SM00028:TPR, 3D-structure,Alternative splicing,Apoptosis,Calcium,Complete proteome,Host-virus interaction,Isomerase,Isopeptide bond,Membrane,Metal-binding,Mitochondrion,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Rotamase,TPR repeat,Transmembrane,Transmembrane helix,Ubl conjugation, chain:FK506-binding protein 8,compositionally biased region:Glu-rich,domain:PPIase FKBP-type,helix,modified residue,repeat:TPR 1,repeat:TPR 2,repeat:TPR 3,sequence conflict,sequence variant,splice variant,strand,transmembrane region,turn, Q5XI81 FMR1 autosomal homolog 1(Fxr1) Rattus norvegicus GO:0007517~muscle organ development,GO:0017148~negative regulation of translation,GO:0030154~cell differentiation,GO:2000637~positive regulation of gene silencing by miRNA, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005844~polysome,GO:0016020~membrane,GO:0030424~axon,GO:0030425~dendrite,GO:0035770~ribonucleoprotein granule,GO:0043034~costamere,GO:0043197~dendritic spine,GO:0048471~perinuclear region of cytoplasm, GO:0002151~G-quadruplex RNA binding,GO:0003729~mRNA binding,GO:0003730~mRNA 3'-UTR binding,GO:0033592~RNA strand annealing activity,GO:0042803~protein homodimerization activity,GO:0044822~poly(A) RNA binding,GO:0046982~protein heterodimerization activity, IPR004087:K Homology domain,IPR004088:K Homology domain, type 1,IPR008395:Agenet-like domain,IPR022034:Fragile X mental retardation protein family, rno03013:RNA transport, SM00322:KH, Acetylation,Complete proteome,Cytoplasm,Developmental protein,Differentiation,Methylation,Myogenesis,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,RNA-binding, chain:Fragile X mental retardation syndrome- related protein 1,compositionally biased region:Poly-Arg,compositionally biased region:Poly-Pro,domain:KH 1,domain:KH 2,modified residue,region of interest:RNA-binding RGG-box, Q9BXW9 Fanconi anemia complementation group D2(FANCD2) Homo sapiens h_atrbrcaPathway:Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility,h_bard1Pathway:BRCA1-dependent Ub-ligase activity, GO:0006281~DNA repair,GO:0007129~synapsis,GO:0007276~gamete generation,GO:0010332~response to gamma radiation,GO:0034599~cellular response to oxidative stress,GO:0036297~interstrand cross-link repair,GO:0045589~regulation of regulatory T cell differentiation,GO:0048854~brain morphogenesis,GO:0050727~regulation of inflammatory response,GO:0051090~regulation of sequence-specific DNA binding transcription factor activity,GO:0097150~neuronal stem cell population maintenance,GO:2000348~regulation of CD40 signaling pathway, GO:0000793~condensed chromosome,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0005737~cytoplasm, GO:0005515~protein binding,GO:0070182~DNA polymerase binding, hsa03460:Fanconi anemia pathway, 227646~Fanconi anemia, complementation group D2, Alternative splicing,Cell cycle,Complete proteome,Disease mutation,DNA damage,DNA repair,Fanconi anemia,Isopeptide bond,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Ubl conjugation, chain:Fanconi anemia group D2 protein,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),modified residue,mutagenesis site,region of interest:Interaction with BRCA2,region of interest:Interaction with FANCE,sequence conflict,sequence variant,splice variant, P20693 Fc receptor, IgE, low affinity II, alpha polypeptide(Fcer2a) Mus musculus GO:0002925~positive regulation of humoral immune response mediated by circulating immunoglobulin,GO:0051000~positive regulation of nitric-oxide synthase activity,GO:0051712~positive regulation of killing of cells of other organism,GO:0051770~positive regulation of nitric-oxide synthase biosynthetic process, GO:0005886~plasma membrane,GO:0009897~external side of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0070062~extracellular exosome, GO:0019863~IgE binding,GO:0030246~carbohydrate binding,GO:0046872~metal ion binding, IPR001304:C-type lectin,IPR016186:C-type lectin-like,IPR016187:C-type lectin fold,IPR018378:C-type lectin, conserved site, mmu04640:Hematopoietic cell lineage,mmu05169:Epstein-Barr virus infection, SM00034:CLECT, 3D-structure,Alternative splicing,Calcium,Cell membrane,Coiled coil,Complete proteome,Disulfide bond,Glycoprotein,IgE-binding protein,Lectin,Lipoprotein,Membrane,Metal-binding,Palmitate,Receptor,Reference proteome,Repeat,Signal,Signal-anchor,Transmembrane,Transmembrane helix, chain:Low affinity immunoglobulin epsilon Fc receptor,disulfide bond,domain:C-type lectin,glycosylation site:N-linked (GlcNAc...),helix,splice variant,strand,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q7TQC7 G patch domain containing 2(Gpatch2) Mus musculus GO:0010923~negative regulation of phosphatase activity, GO:0005634~nucleus,GO:0005730~nucleolus,GO:0016607~nuclear speck, GO:0003676~nucleic acid binding, IPR000467:G-patch domain,IPR026291:G patch domain-containing protein 2, SM00443:G_patch, Alternative splicing,Complete proteome,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome, chain:G patch domain-containing protein 2,domain:G-patch,modified residue,sequence conflict,splice variant, E9PVA8 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)(Gcn1l1) Mus musculus Energy production and conversion, GO:0006417~regulation of translation,GO:0033554~cellular response to stress,GO:0033674~positive regulation of kinase activity,GO:0034198~cellular response to amino acid starvation,GO:0036003~positive regulation of transcription from RNA polymerase II promoter in response to stress,GO:1990253~cellular response to leucine starvation, GO:0005737~cytoplasm,GO:0005844~polysome,GO:0005913~cell-cell adherens junction,GO:0016020~membrane, GO:0005515~protein binding,GO:0019887~protein kinase regulator activity,GO:0019901~protein kinase binding,GO:0043022~ribosome binding,GO:0044822~poly(A) RNA binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000225:Armadillo,IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold,IPR021133:HEAT, type 2,IPR026827:Proteasome component ECM29/Translational activator GCN1, SM00185:ARM, Acetylation,Activator,Coiled coil,Complete proteome,Cytoplasm,Phosphoprotein,Reference proteome,Repeat,Stress response,Translation regulation, B4NKI9 GK14504 gene product from transcript GK14504-RA(Dwil\GK14504) Drosophila willistoni GO:0006338~chromatin remodeling,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0019919~peptidyl-arginine methylation, to asymmetrical-dimethyl arginine,GO:0034969~histone arginine methylation, GO:0005634~nucleus,GO:0005737~cytoplasm, GO:0035241~protein-arginine omega-N monomethyltransferase activity,GO:0035242~protein-arginine omega-N asymmetric methyltransferase activity,GO:0042054~histone methyltransferase activity, IPR020989:Histone-arginine methyltransferase CARM1, N-terminal,IPR025799:Protein arginine N-methyltransferase, Chromatin regulator,Complete proteome,Cytoplasm,Methylation,Methyltransferase,Nucleus,Reference proteome,S-adenosyl-L-methionine,Transcription,Transcription regulation,Transferase, binding site:S-adenosyl-L-methionine,binding site:S-adenosyl-L-methionine; via carbonyl oxygen,chain:Histone-arginine methyltransferase CARMER,modified residue, Q9WTK3 GPI anchor attachment protein 1(Gpaa1) Mus musculus GO:0006506~GPI anchor biosynthetic process,GO:0016255~attachment of GPI anchor to protein, GO:0005783~endoplasmic reticulum,GO:0005887~integral component of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0042765~GPI-anchor transamidase complex, GO:0003923~GPI-anchor transamidase activity,GO:0034235~GPI anchor binding, IPR007246:Gaa1-like, GPI transamidase component, mmu00563:Glycosylphosphatidylinositol(GPI)-anchor biosynthesis,mmu01100:Metabolic pathways, PIRSF036762:glycosylphosphatidylinositol:protein transamidase, GAA1 component, Complete proteome,Endoplasmic reticulum,Glycoprotein,GPI-anchor biosynthesis,Membrane,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix, chain:Glycosylphosphatidylinositol anchor attachment 1 protein,glycosylation site:N-linked (GlcNAc...),topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, A7XDQ9 Galactosyltransferase family protein(AT4G21060) Arabidopsis thaliana GO:0006486~protein glycosylation,GO:0010405~arabinogalactan protein metabolic process,GO:0018258~protein O-linked glycosylation via hydroxyproline,GO:0080147~root hair cell development, GO:0000139~Golgi membrane,GO:0005794~Golgi apparatus,GO:0012505~endomembrane system,GO:0016021~integral component of membrane, GO:0008378~galactosyltransferase activity,GO:0016757~transferase activity, transferring glycosyl groups,GO:0016758~transferase activity, transferring hexosyl groups,GO:0030246~carbohydrate binding,GO:0035250~UDP-galactosyltransferase activity,GO:1990714~hydroxyproline O-galactosyltransferase activity, IPR001079:Galectin, carbohydrate recognition domain,IPR002659:Glycosyl transferase, family 31,IPR013320:Concanavalin A-like lectin/glucanase, subgroup, SM00908:SM00908, Alternative splicing,Complete proteome,Glycoprotein,Glycosyltransferase,Golgi apparatus,Manganese,Membrane,Reference proteome,Signal-anchor,Transferase,Transmembrane,Transmembrane helix, chain:Probable beta-1,3-galactosyltransferase 20,domain:Galectin,glycosylation site:N-linked (GlcNAc...),transmembrane region, Q9VFC8 Glycogen synthase(GlyS) Drosophila melanogaster GO:0005977~glycogen metabolic process,GO:0005978~glycogen biosynthetic process,GO:0009267~cellular response to starvation,GO:0009744~response to sucrose,GO:0045819~positive regulation of glycogen catabolic process,GO:0061723~glycophagy,GO:0071329~cellular response to sucrose stimulus, GO:0005776~autophagosome,GO:0031410~cytoplasmic vesicle, GO:0004373~glycogen (starch) synthase activity, IPR008631:Glycogen synthase, dme00500:Starch and sucrose metabolism,dme04931:Insulin resistance, Alternative splicing,Complete proteome,Cytoplasmic vesicle,Glycogen biosynthesis,Glycosyltransferase,Phosphoprotein,Proteomics identification,Reference proteome,Transferase, binding site:UDP-glucose,chain:Putative glycogen [starch] synthase,modified residue,splice variant, Q9H6D7 HAUS augmin like complex subunit 4(HAUS4) Homo sapiens GO:0000086~G2/M transition of mitotic cell cycle,GO:0007067~mitotic nuclear division,GO:0051225~spindle assembly,GO:0051297~centrosome organization,GO:0051301~cell division, GO:0005813~centrosome,GO:0005819~spindle,GO:0005829~cytosol,GO:0005874~microtubule,GO:0070652~HAUS complex, IPR026214:HAUS augmin-like complex subunit 4, Alternative splicing,Cell cycle,Cell division,Complete proteome,Cytoplasm,Cytoskeleton,Microtubule,Mitosis,Proteomics identification,Reference proteome, chain:HAUS augmin-like complex subunit 4,sequence conflict,splice variant, O95714 HECT and RLD domain containing E3 ubiquitin protein ligase 2(HERC2) Homo sapiens Cell division and chromosome partitioning / Cytoskeleton, GO:0006303~double-strand break repair via nonhomologous end joining,GO:0006886~intracellular protein transport,GO:0006974~cellular response to DNA damage stimulus,GO:0007283~spermatogenesis,GO:0016567~protein ubiquitination,GO:0016925~protein sumoylation,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process,GO:0043547~positive regulation of GTPase activity, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005743~mitochondrial inner membrane,GO:0005814~centriole,GO:0016020~membrane, GO:0004842~ubiquitin-protein transferase activity,GO:0005085~guanyl-nucleotide exchange factor activity,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0031625~ubiquitin protein ligase binding,GO:0032183~SUMO binding, IPR000408:Regulator of chromosome condensation, RCC1,IPR000433:Zinc finger, ZZ-type,IPR000569:HECT,IPR001199:Cytochrome b5-like heme/steroid binding domain,IPR004939:Anaphase-promoting complex, subunit 10/DOC domain,IPR006624:Beta-propeller repeat TECPR,IPR008979:Galactose-binding domain-like,IPR009091:Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II,IPR010606:Mib-herc2,IPR014722:Ribosomal protein L2 domain 2,IPR021097:CPH domain, hsa04120:Ubiquitin mediated proteolysis, 227220~Skin/hair/eye pigmentation 1, blond/brown hair,227220~Skin/hair/eye pigmentation 1, blue/nonblue eyes,615516~Mental retardation, autosomal recessive 38, SM00119:HECTc,SM00291:ZnF_ZZ,SM00706:TECPR,SM01117:SM01117,SM01337:SM01337, 3D-structure,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Disease mutation,DNA damage,DNA repair,Mental retardation,Metal-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Transferase,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, active site:Glycyl thioester intermediate,chain:Probable E3 ubiquitin-protein ligase HERC2,domain:Cytochrome b5 heme-binding,domain:DOC,domain:HECT,domain:MIB/HERC2,helix,modified residue,repeat:RCC1 1,repeat:RCC1 10,repeat:RCC1 11,repeat:RCC1 12,repeat:RCC1 13,repeat:RCC1 14,repeat:RCC1 15,repeat:RCC1 16,repeat:RCC1 17,repeat:RCC1 18,repeat:RCC1 19,repeat:RCC1 2,repeat:RCC1 3,repeat:RCC1 4,repeat:RCC1 5,repeat:RCC1 6,repeat:RCC1 7,repeat:RCC1 8,repeat:RCC1 9,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,sequence conflict,strand,turn,zinc finger region:ZZ-type, Q5PQN1 HECT and RLD domain containing E3 ubiquitin protein ligase 4(Herc4) Rattus norvegicus Cell division and chromosome partitioning / Cytoskeleton, GO:0007283~spermatogenesis,GO:0030154~cell differentiation,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0004842~ubiquitin-protein transferase activity, IPR000408:Regulator of chromosome condensation, RCC1,IPR000569:HECT,IPR009091:Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II, rno04120:Ubiquitin mediated proteolysis, SM00119:HECTc, Complete proteome,Cytoplasm,Differentiation,Reference proteome,Repeat,Spermatogenesis,Transferase,Ubl conjugation pathway, active site:Glycyl thioester intermediate,chain:Probable E3 ubiquitin-protein ligase HERC4,domain:HECT,modified residue,repeat:RCC1 1,repeat:RCC1 2,repeat:RCC1 3,repeat:RCC1 4,repeat:RCC1 5,repeat:RCC1 6,repeat:RCC1 7, Q7Z6Z7 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase(HUWE1) Homo sapiens GO:0000209~protein polyubiquitination,GO:0006284~base-excision repair,GO:0006513~protein monoubiquitination,GO:0016574~histone ubiquitination,GO:0030154~cell differentiation,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process,GO:1903955~positive regulation of protein targeting to mitochondrion, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0070062~extracellular exosome, GO:0003677~DNA binding,GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0016874~ligase activity,GO:0044822~poly(A) RNA binding, IPR000569:HECT,IPR004170:WWE domain,IPR009060:UBA-like,IPR010309:E3 ubiquitin ligase, domain of unknown function DUF908,IPR010314:E3 ubiquitin ligase, domain of unknown function DUF913,IPR015940:Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote,IPR016024:Armadillo-type fold,IPR025527:Domain of unknown function DUF4414, hsa04120:Ubiquitin mediated proteolysis, 300706~Mental retardation, X-linked syndromic, Turner type, SM00119:HECTc,SM00165:UBA, 3D-structure,Acetylation,Alternative splicing,Chromosomal rearrangement,Coiled coil,Complete proteome,Cytoplasm,Differentiation,Disease mutation,DNA damage,DNA repair,DNA-binding,Membrane,Mental retardation,Methylation,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transferase,Transmembrane,Transmembrane helix,Ubl conjugation pathway, active site:Glycyl thioester intermediate,chain:E3 ubiquitin-protein ligase HUWE1,compositionally biased region:Asp-rich,compositionally biased region:Glu-rich,compositionally biased region:Thr-rich,domain:HECT,domain:UBA,domain:WWE,helix,modified residue,mutagenesis site,repeat:UIM,sequence conflict,sequence variant,splice variant,strand,turn, Q8IV36 HID1 domain containing(HID1) Homo sapiens GO:0006886~intracellular protein transport,GO:0031001~response to brefeldin A, GO:0000138~Golgi trans cisterna,GO:0005737~cytoplasm,GO:0005794~Golgi apparatus,GO:0005797~Golgi medial cisterna,GO:0005881~cytoplasmic microtubule,GO:0070062~extracellular exosome,GO:0090498~extrinsic component of Golgi membrane, GO:0005515~protein binding, IPR026705:Hid-1, Alternative splicing,Complete proteome,Cytoplasm,Golgi apparatus,Lipoprotein,Membrane,Myristate,Phosphoprotein,Proteomics identification,Reference proteome, chain:UPF0663 transmembrane protein C17orf28,modified residue,sequence conflict,splice variant,transmembrane region, Q9UPZ3 HPS5, biogenesis of lysosomal organelles complex 2 subunit 2(HPS5) Homo sapiens GO:0006996~organelle organization,GO:0007596~blood coagulation,GO:0043473~pigmentation, GO:0031084~BLOC-2 complex, GO:0005515~protein binding, IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain, 614074~Hermansky-Pudlak syndrome 5, Albinism,Alternative splicing,Complete proteome,Cytoplasm,Disease mutation,Hermansky-Pudlak syndrome,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:Hermansky-Pudlak syndrome 5 protein,compositionally biased region:Poly-Ala,modified residue,sequence conflict,sequence variant,splice variant, Q20296 Histone DeAcetylase(hda-6) Caenorhabditis elegans Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006476~protein deacetylation,GO:0008152~metabolic process,GO:0016575~histone deacetylation,GO:0070932~histone H3 deacetylation, GO:0005634~nucleus, GO:0004407~histone deacetylase activity,GO:0008270~zinc ion binding,GO:0016787~hydrolase activity,GO:0032041~NAD-dependent histone deacetylase activity (H3-K14 specific),GO:0033558~protein deacetylase activity,GO:0046872~metal ion binding, IPR000286:Histone deacetylase superfamily,IPR001607:Zinc finger, UBP-type,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR023801:Histone deacetylase domain, SM00290:ZnF_UBP, Alternative splicing,Chromatin regulator,Complete proteome,Hydrolase,Metal-binding,Nucleus,Proteomics identification,Reference proteome,Repeat,Repressor,Transcription,Transcription regulation,Zinc,Zinc-finger, active site:1,active site:2,chain:Histone deacetylase 6,region of interest:Histone deacetylase 1,region of interest:Histone deacetylase 2,splice variant,zinc finger region:UBP-type, Q5NVI3 IK cytokine, down-regulator of HLA II(IK) Pongo abelii GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus, IPR012492:Protein RED, C-terminal,IPR012916:RED-like, N-terminal, Acetylation,Coiled coil,Complete proteome,Isopeptide bond,Nucleus,Phosphoprotein,Reference proteome,Repeat,Ubl conjugation, chain:Protein Red,compositionally biased region:Poly-Glu,modified residue,region of interest:17 X 2 AA tandem repeats of R-[ED],repeat:1,repeat:10,repeat:11,repeat:12,repeat:13,repeat:14,repeat:15,repeat:16,repeat:17,repeat:2,repeat:3,repeat:4,repeat:5,repeat:6,repeat:7,repeat:8,repeat:9, Q66HG8 IK cytokine, down-regulator of HLA II(Ik) Rattus norvegicus GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus, GO:0042802~identical protein binding, IPR012492:Protein RED, C-terminal,IPR012916:RED-like, N-terminal, Acetylation,Coiled coil,Complete proteome,Direct protein sequencing,Isopeptide bond,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Ubl conjugation, chain:Protein Red,chain:WD repeat-containing protein 55,compositionally biased region:Poly-Glu,modified residue,region of interest:17 X 2 AA tandem repeats of R-[ED],repeat:1,repeat:10,repeat:11,repeat:12,repeat:13,repeat:14,repeat:15,repeat:16,repeat:17,repeat:2,repeat:3,repeat:4,repeat:5,repeat:6,repeat:7,repeat:8,repeat:9,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7, Q6DN90 IQ motif and Sec7 domain 1(IQSEC1) Homo sapiens GO:0030036~actin cytoskeleton organization,GO:0032012~regulation of ARF protein signal transduction,GO:0043547~positive regulation of GTPase activity, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0016020~membrane, GO:0005086~ARF guanyl-nucleotide exchange factor activity,GO:0005515~protein binding,GO:0008289~lipid binding, IPR000048:IQ motif, EF-hand binding site,IPR000904:SEC7-like,IPR001849:Pleckstrin homology domain,IPR011993:Pleckstrin homology-like domain,IPR023394:SEC7-like, alpha orthogonal bundle, hsa04144:Endocytosis, SM00222:Sec7,SM00233:PH, 3D-structure,Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Guanine-nucleotide releasing factor,Lipid-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:IQ motif and SEC7 domain-containing protein 1,domain:IQ,domain:PH,domain:SEC7,modified residue,sequence conflict,sequence variant,splice variant, P46940 IQ motif containing GTPase activating protein 1(IQGAP1) Homo sapiens Cell division and chromosome partitioning / Signal transduction mechanisms, GO:0001817~regulation of cytokine production,GO:0007165~signal transduction,GO:0007173~epidermal growth factor receptor signaling pathway,GO:0008543~fibroblast growth factor receptor signaling pathway,GO:0034260~negative regulation of GTPase activity,GO:0035305~negative regulation of dephosphorylation,GO:0036120~cellular response to platelet-derived growth factor stimulus,GO:0043087~regulation of GTPase activity,GO:0043406~positive regulation of MAP kinase activity,GO:0043547~positive regulation of GTPase activity,GO:0045860~positive regulation of protein kinase activity,GO:0048008~platelet-derived growth factor receptor signaling pathway,GO:0051894~positive regulation of focal adhesion assembly,GO:0071277~cellular response to calcium ion,GO:0071364~cellular response to epidermal growth factor stimulus,GO:0072015~glomerular visceral epithelial cell development,GO:0098609~cell-cell adhesion,GO:1900006~positive regulation of dendrite development,GO:1900086~positive regulation of peptidyl-tyrosine autophosphorylation,GO:1903829~positive regulation of cellular protein localization,GO:1904754~positive regulation of vascular associated smooth muscle cell migration,GO:1990138~neuron projection extension,GO:1990776~response to angiotensin, GO:0001726~ruffle,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005874~microtubule,GO:0005884~actin filament,GO:0005886~plasma membrane,GO:0005911~cell-cell junction,GO:0005913~cell-cell adherens junction,GO:0005925~focal adhesion,GO:0015629~actin cytoskeleton,GO:0015630~microtubule cytoskeleton,GO:0016328~lateral plasma membrane,GO:0030424~axon,GO:0030426~growth cone,GO:0030496~midbody,GO:0030529~intracellular ribonucleoprotein complex,GO:0031234~extrinsic component of cytoplasmic side of plasma membrane,GO:0031252~cell leading edge,GO:0036057~slit diaphragm,GO:0036464~cytoplasmic ribonucleoprotein granule,GO:0043005~neuron projection,GO:0043234~protein complex,GO:0045121~membrane raft,GO:0070062~extracellular exosome, GO:0005095~GTPase inhibitor activity,GO:0005096~GTPase activator activity,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0005547~phosphatidylinositol-3,4,5-trisphosphate binding,GO:0019901~protein kinase binding,GO:0019903~protein phosphatase binding,GO:0019904~protein domain specific binding,GO:0032403~protein complex binding,GO:0043539~protein serine/threonine kinase activator activity,GO:0044548~S100 protein binding,GO:0048365~Rac GTPase binding,GO:0051019~mitogen-activated protein kinase binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000048:IQ motif, EF-hand binding site,IPR000593:RasGAP protein, C-terminal,IPR001202:WW domain,IPR001715:Calponin homology domain,IPR001936:Ras GTPase-activating protein,IPR008936:Rho GTPase activation protein,IPR023152:Ras GTPase-activating protein, conserved site,IPR027401:Myosin-like IQ motif-containing domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa04520:Adherens junction,hsa04810:Regulation of actin cytoskeleton,hsa05205:Proteoglycans in cancer, SM00015:IQ,SM00033:CH,SM00323:RasGAP,SM00456:WW, 3D-structure,Acetylation,Calmodulin-binding,Cell membrane,Coiled coil,Complete proteome,Direct protein sequencing,Membrane,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Signal, chain:Ras GTPase-activating-like protein IQGAP1,domain:CH,domain:IQ 1,domain:IQ 2,domain:IQ 3,domain:IQ 4,domain:Ras-GAP,domain:WW,helix,modified residue,mutagenesis site,region of interest:C1,region of interest:C2,sequence variant,strand,turn, O18023 Ig-like and fibronectin type-III domain-containing protein 2(igdb-2) Caenorhabditis elegans GO:0030334~regulation of cell migration,GO:0048739~cardiac muscle fiber development,GO:0051493~regulation of cytoskeleton organization, GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030018~Z disc, GO:0051015~actin filament binding, IPR002602:Domain of unknown function DB,IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR003961:Fibronectin, type III,IPR006150:Cysteine-rich repeat,IPR007110:Immunoglobulin-like domain,IPR013151:Immunoglobulin,IPR013783:Immunoglobulin-like fold, SM00060:FN3,SM00289:WR1,SM00408:IGc2,SM00409:IG, Alternative splicing,Cell membrane,Complete proteome,Disulfide bond,Glycoprotein,Immunoglobulin domain,Membrane,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Ig-like and fibronectin type-III domain- containing protein C25G4.10,chain:Ig-like and fibronectin type-III domain- containing protein T04A11.3,disulfide bond,domain:Fibronectin type-III 1,domain:Fibronectin type-III 2,domain:Fibronectin type-III 3,domain:Fibronectin type-III 4,domain:Fibronectin type-III 5,domain:Ig-like C2-type,domain:WR1,glycosylation site:N-linked (GlcNAc...),signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q21926 Isoleucine--tRNA ligase, cytoplasmic(iars-1) Caenorhabditis elegans GO:0000003~reproduction,GO:0002119~nematode larval development,GO:0006412~translation,GO:0006418~tRNA aminoacylation for protein translation,GO:0006428~isoleucyl-tRNA aminoacylation,GO:0006450~regulation of translational fidelity,GO:0006898~receptor-mediated endocytosis,GO:0009792~embryo development ending in birth or egg hatching, GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0000049~tRNA binding,GO:0000166~nucleotide binding,GO:0002161~aminoacyl-tRNA editing activity,GO:0004812~aminoacyl-tRNA ligase activity,GO:0004822~isoleucine-tRNA ligase activity,GO:0005524~ATP binding,GO:0016874~ligase activity, IPR001412:Aminoacyl-tRNA synthetase, class I, conserved site,IPR002300:Aminoacyl-tRNA synthetase, class Ia,IPR002301:Isoleucine-tRNA ligase,IPR009008:Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing domain,IPR009080:Aminoacyl-tRNA synthetase, class 1a, anticodon-binding,IPR013155:Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding,IPR014729:Rossmann-like alpha/beta/alpha sandwich fold,IPR023586:Isoleucine-tRNA ligase, type 2, cel00970:Aminoacyl-tRNA biosynthesis, Aminoacyl-tRNA synthetase,ATP-binding,Complete proteome,Cytoplasm,Ligase,Nucleotide-binding,Protein biosynthesis,Reference proteome, binding site:ATP,chain:Isoleucyl-tRNA synthetase, cytoplasmic,short sequence motif:"HIGH" region,short sequence motif:"KMSKS" region, Q5VZ66 Janus kinase and microtubule interacting protein 3(JAKMIP3) Homo sapiens GO:0005794~Golgi apparatus, GO:0008017~microtubule binding,GO:0019900~kinase binding, IPR024836:Janus kinase and microtubule-interacting protein, Alternative splicing,Coiled coil,Complete proteome,Golgi apparatus,Phosphoprotein,Polymorphism,Reference proteome, chain:Janus kinase and microtubule-interacting protein 3,sequence variant,splice variant, Q8UVD9 KH-type splicing regulatory protein(KHSRP) Gallus gallus GO:0008298~intracellular mRNA localization,GO:0043488~regulation of mRNA stability,GO:0045019~negative regulation of nitric oxide biosynthetic process,GO:0051028~mRNA transport,GO:0061014~positive regulation of mRNA catabolic process,GO:0061158~3'-UTR-mediated mRNA destabilization,GO:0071345~cellular response to cytokine stimulus, GO:0005634~nucleus,GO:0005737~cytoplasm, GO:0003730~mRNA 3'-UTR binding,GO:0035925~mRNA 3'-UTR AU-rich region binding, IPR004087:K Homology domain,IPR004088:K Homology domain, type 1,IPR015096:Domain of unknown function DUF1897, SM00322:KH, Complete proteome,Cytoplasm,Direct protein sequencing,mRNA transport,Nucleus,Reference proteome,Repeat,RNA-binding,Transport, chain:Far upstream element-binding protein 2,domain:KH 1,domain:KH 2,domain:KH 3,domain:KH 4, Q5VV43 KIAA0319(KIAA0319) Homo sapiens GO:0001764~neuron migration,GO:2000171~negative regulation of dendrite development, GO:0005769~early endosome,GO:0005886~plasma membrane,GO:0016021~integral component of membrane,GO:0031901~early endosome membrane, GO:0005515~protein binding, IPR000601:PKD domain,IPR002859:PKD/REJ-like protein,IPR003961:Fibronectin, type III,IPR011106:Seven cysteines, N-terminal,IPR013980:Seven cysteines,IPR022409:PKD/Chitinase domain, 600202~Dyslexia, susceptibility to, 2, SM00060:FN3,SM00089:PKD,SM00765:MANEC, 3D-structure,Alternative splicing,Cell membrane,Complete proteome,Developmental protein,Endosome,Glycoprotein,Membrane,Neurogenesis,Polymorphism,Proteomics identification,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Uncharacterized protein KIAA0319,domain:MANSC,domain:PKD 1,domain:PKD 2,glycosylation site:N-linked (GlcNAc...),sequence conflict,sequence variant,signal peptide,splice variant,strand,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, E1BZ85 KIAA0430(KIAA0430) Gallus gallus GO:0006302~double-strand break repair,GO:0007143~female meiotic division,GO:0010468~regulation of gene expression,GO:0010923~negative regulation of phosphatase activity,GO:0048477~oogenesis,GO:0051321~meiotic cell cycle, GO:0005777~peroxisome,GO:0016020~membrane, GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0003723~RNA binding, IPR000504:RNA recognition motif domain,IPR012677:Nucleotide-binding, alpha-beta plait,IPR021139:NYN domain, limkain-b1-type,IPR024582:Limkain b1, conserved domain,IPR024768:Limkain-b1,IPR025605:OST-HTH/LOTUS domain, SM00360:RRM, Complete proteome,Differentiation,Meiosis,Oogenesis,Peroxisome,Reference proteome,Repeat,RNA-binding, Q1G7G9 KIAA0586(KIAA0586) Gallus gallus GO:0007224~smoothened signaling pathway,GO:0042384~cilium assembly,GO:0044458~motile cilium assembly,GO:0051642~centrosome localization,GO:0060271~cilium morphogenesis,GO:0070201~regulation of establishment of protein localization, GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005814~centriole,GO:0036064~ciliary basal body, Cilium biogenesis/degradation,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Reference proteome, Q8IV33 KIAA0825(KIAA0825) Homo sapiens Alternative splicing,Complete proteome,Polymorphism,Proteomics identification,Reference proteome, chain:Uncharacterized protein C5orf36,sequence variant, Q6NV74 KIAA1211 like(KIAA1211L) Homo sapiens IPR026713:Probable exonuclease mut-7 homolog, isoform 5, Complete proteome,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:Uncharacterized protein C2orf55,compositionally biased region:Pro-rich,modified residue,sequence conflict,sequence variant, Q6ZUG5 KIAA1257(KIAA1257) Homo sapiens Alternative splicing,Complete proteome,Reference proteome, chain:Uncharacterized protein KIAA1257,splice variant, Q83F39 L-threonine 3-dehydrogenase(tdh) Coxiella burnetii RSA 493 GO:0006567~threonine catabolic process,GO:0019518~L-threonine catabolic process to glycine, GO:0005737~cytoplasm, GO:0008270~zinc ion binding,GO:0008743~L-threonine 3-dehydrogenase activity, IPR002085:Alcohol dehydrogenase superfamily, zinc-type,IPR002328:Alcohol dehydrogenase, zinc-type, conserved site,IPR004627:L-threonine 3-dehydrogenase,IPR011032:GroES-like,IPR013149:Alcohol dehydrogenase, C-terminal,IPR013154:Alcohol dehydrogenase GroES-like,IPR016040:NAD(P)-binding domain,IPR020843:Polyketide synthase, enoylreductase, cbu00260:Glycine, serine and threonine metabolism, SM00829:SM00829, Complete proteome,Cytoplasm,Metal-binding,NAD,Oxidoreductase,Reference proteome,Zinc, chain:L-threonine 3-dehydrogenase,metal ion-binding site:Zinc 1; catalytic,metal ion-binding site:Zinc 2, Q9NZR2 LDL receptor related protein 1B(LRP1B) Homo sapiens GO:0006898~receptor-mediated endocytosis,GO:0015031~protein transport, GO:0016021~integral component of membrane,GO:0043235~receptor complex, GO:0005509~calcium ion binding, IPR000033:LDLR class B repeat,IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR001881:EGF-like calcium-binding,IPR002172:Low-density lipoprotein (LDL) receptor class A repeat,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR011042:Six-bladed beta-propeller, TolB-like,IPR013032:EGF-like, conserved site,IPR018097:EGF-like calcium-binding, conserved site,IPR023415:Low-density lipoprotein (LDL) receptor class A, conserved site,IPR026823:Complement Clr-like EGF domain, SM00135:LY,SM00179:EGF_CA,SM00181:EGF,SM00192:LDLa, Calcium,Complete proteome,Disulfide bond,EGF-like domain,Endocytosis,Glycoprotein,Membrane,Phosphoprotein,Polymorphism,Proteomics identification,Receptor,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Low-density lipoprotein receptor-related protein 1B,disulfide bond,domain:EGF-like 1,domain:EGF-like 10,domain:EGF-like 11,domain:EGF-like 12,domain:EGF-like 13,domain:EGF-like 14,domain:EGF-like 2; calcium-binding,domain:EGF-like 3,domain:EGF-like 4,domain:EGF-like 5,domain:EGF-like 6,domain:EGF-like 7,domain:EGF-like 8,domain:EGF-like 9,domain:LDL-receptor class A 1,domain:LDL-receptor class A 10,domain:LDL-receptor class A 11,domain:LDL-receptor class A 12,domain:LDL-receptor class A 13,domain:LDL-receptor class A 14,domain:LDL-receptor class A 15,domain:LDL-receptor class A 16,domain:LDL-receptor class A 17,domain:LDL-receptor class A 18,domain:LDL-receptor class A 19,domain:LDL-receptor class A 2,domain:LDL-receptor class A 20,domain:LDL-receptor class A 21,domain:LDL-receptor class A 22,domain:LDL-receptor class A 23,domain:LDL-receptor class A 24,domain:LDL-receptor class A 25,domain:LDL-receptor class A 26,domain:LDL-receptor class A 27,domain:LDL-receptor class A 28,domain:LDL-receptor class A 29,domain:LDL-receptor class A 3,domain:LDL-receptor class A 30,domain:LDL-receptor class A 31,domain:LDL-receptor class A 32,domain:LDL-receptor class A 4,domain:LDL-receptor class A 5,domain:LDL-receptor class A 6,domain:LDL-receptor class A 7,domain:LDL-receptor class A 8,domain:LDL-receptor class A 9,glycosylation site:N-linked (GlcNAc...),repeat:LDL-receptor class B 1,repeat:LDL-receptor class B 10,repeat:LDL-receptor class B 11,repeat:LDL-receptor class B 12,repeat:LDL-receptor class B 13,repeat:LDL-receptor class B 14,repeat:LDL-receptor class B 15,repeat:LDL-receptor class B 16,repeat:LDL-receptor class B 17,repeat:LDL-receptor class B 18,repeat:LDL-receptor class B 19,repeat:LDL-receptor class B 2,repeat:LDL-receptor class B 20,repeat:LDL-receptor class B 21,repeat:LDL-receptor class B 22,repeat:LDL-receptor class B 23,repeat:LDL-receptor class B 24,repeat:LDL-receptor class B 25,repeat:LDL-receptor class B 26,repeat:LDL-receptor class B 27,repeat:LDL-receptor class B 28,repeat:LDL-receptor class B 29,repeat:LDL-receptor class B 3,repeat:LDL-receptor class B 30,repeat:LDL-receptor class B 31,repeat:LDL-receptor class B 32,repeat:LDL-receptor class B 33,repeat:LDL-receptor class B 34,repeat:LDL-receptor class B 35,repeat:LDL-receptor class B 36,repeat:LDL-receptor class B 4,repeat:LDL-receptor class B 5,repeat:LDL-receptor class B 6,repeat:LDL-receptor class B 7,repeat:LDL-receptor class B 8,repeat:LDL-receptor class B 9,sequence conflict,sequence variant,short sequence motif:Endocytosis signal,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, O75581 LDL receptor related protein 6(LRP6) Homo sapiens h_wnt-Lrp6Pathway:Wnt/LRP6 Signalling, GO:0001843~neural tube closure,GO:0001933~negative regulation of protein phosphorylation,GO:0003344~pericardium morphogenesis,GO:0006469~negative regulation of protein kinase activity,GO:0007204~positive regulation of cytosolic calcium ion concentration,GO:0007268~chemical synaptic transmission,GO:0009880~embryonic pattern specification,GO:0014029~neural crest formation,GO:0014033~neural crest cell differentiation,GO:0016055~Wnt signaling pathway,GO:0016337~single organismal cell-cell adhesion,GO:0021587~cerebellum morphogenesis,GO:0021794~thalamus development,GO:0021987~cerebral cortex development,GO:0030917~midbrain-hindbrain boundary development,GO:0034392~negative regulation of smooth muscle cell apoptotic process,GO:0035261~external genitalia morphogenesis,GO:0042475~odontogenesis of dentin-containing tooth,GO:0043434~response to peptide hormone,GO:0044332~Wnt signaling pathway involved in dorsal/ventral axis specification,GO:0044335~canonical Wnt signaling pathway involved in neural crest cell differentiation,GO:0044340~canonical Wnt signaling pathway involved in regulation of cell proliferation,GO:0045787~positive regulation of cell cycle,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0051091~positive regulation of sequence-specific DNA binding transcription factor activity,GO:0060021~palate development,GO:0060026~convergent extension,GO:0060059~embryonic retina morphogenesis in camera-type eye,GO:0060070~canonical Wnt signaling pathway,GO:0060325~face morphogenesis,GO:0060535~trachea cartilage morphogenesis,GO:0071397~cellular response to cholesterol,GO:0071542~dopaminergic neuron differentiation,GO:0071901~negative regulation of protein serine/threonine kinase activity,GO:0072659~protein localization to plasma membrane,GO:0090009~primitive streak formation,GO:0090090~negative regulation of canonical Wnt signaling pathway,GO:0090118~receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport,GO:0090244~Wnt signaling pathway involved in somitogenesis,GO:0090245~axis elongation involved in somitogenesis,GO:0090263~positive regulation of canonical Wnt signaling pathway,GO:1901998~toxin transport,GO:1904886~beta-catenin destruction complex disassembly,GO:1904948~midbrain dopaminergic neuron differentiation,GO:1904953~Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation,GO:2000055~positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification, GO:0005576~extracellular region,GO:0005769~early endosome,GO:0005783~endoplasmic reticulum,GO:0005794~Golgi apparatus,GO:0005886~plasma membrane,GO:0005901~caveola,GO:0009986~cell surface,GO:0016021~integral component of membrane,GO:0031410~cytoplasmic vesicle,GO:0031901~early endosome membrane,GO:0043025~neuronal cell body,GO:0043235~receptor complex,GO:0045202~synapse,GO:1990851~Wnt-Frizzled-LRP5/6 complex,GO:1990909~Wnt signalosome, GO:0005041~low-density lipoprotein receptor activity,GO:0005102~receptor binding,GO:0005109~frizzled binding,GO:0005515~protein binding,GO:0017147~Wnt-protein binding,GO:0019210~kinase inhibitor activity,GO:0019534~toxin transporter activity,GO:0034185~apolipoprotein binding,GO:0042802~identical protein binding,GO:0042803~protein homodimerization activity,GO:0042813~Wnt-activated receptor activity,GO:0071936~coreceptor activity involved in Wnt signaling pathway,GO:1904928~coreceptor activity involved in canonical Wnt signaling pathway, IPR000033:LDLR class B repeat,IPR000742:Epidermal growth factor-like domain,IPR002172:Low-density lipoprotein (LDL) receptor class A repeat,IPR011042:Six-bladed beta-propeller, TolB-like,IPR017049:Low density lipoprotein receptor-related protein, 5/6,IPR023415:Low-density lipoprotein (LDL) receptor class A, conserved site, hsa04310:Wnt signaling pathway, 610947~Coronary artery disease, autosomal dominant, 2,616724~Tooth agenesis, selective, 7, PIRSF036314:low density lipoprotein receptor-related protein, 5/6 types, SM00135:LY,SM00181:EGF,SM00192:LDLa, 3D-structure,Cell membrane,Complete proteome,Developmental protein,Disease mutation,Disulfide bond,EGF-like domain,Endocytosis,Endoplasmic reticulum,Glycoprotein,Isopeptide bond,Lipoprotein,Membrane,Palmitate,Phosphoprotein,Polymorphism,Proteomics identification,Receptor,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix,Ubl conjugation,Wnt signaling pathway, chain:Low-density lipoprotein receptor-related protein 6,disulfide bond,domain:EGF-like 1,domain:EGF-like 2,domain:EGF-like 3,domain:EGF-like 4,domain:LDL-receptor class A 1,domain:LDL-receptor class A 2,domain:LDL-receptor class A 3,glycosylation site:N-linked (GlcNAc...),repeat:LDL-receptor class B 1,repeat:LDL-receptor class B 10,repeat:LDL-receptor class B 11,repeat:LDL-receptor class B 12,repeat:LDL-receptor class B 13,repeat:LDL-receptor class B 14,repeat:LDL-receptor class B 15,repeat:LDL-receptor class B 16,repeat:LDL-receptor class B 17,repeat:LDL-receptor class B 18,repeat:LDL-receptor class B 19,repeat:LDL-receptor class B 2,repeat:LDL-receptor class B 20,repeat:LDL-receptor class B 3,repeat:LDL-receptor class B 4,repeat:LDL-receptor class B 5,repeat:LDL-receptor class B 6,repeat:LDL-receptor class B 7,repeat:LDL-receptor class B 8,repeat:LDL-receptor class B 9,sequence variant,short sequence motif:PPPSP motif,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q8K4K5 LLGL1, scribble cell polarity complex component(Llgl1) Rattus norvegicus GO:0006461~protein complex assembly,GO:0006887~exocytosis,GO:0006893~Golgi to plasma membrane transport,GO:0007409~axonogenesis,GO:0008593~regulation of Notch signaling pathway,GO:0017157~regulation of exocytosis,GO:0030866~cortical actin cytoskeleton organization,GO:0032878~regulation of establishment or maintenance of cell polarity,GO:0035090~maintenance of apical/basal cell polarity,GO:0043547~positive regulation of GTPase activity,GO:0050708~regulation of protein secretion,GO:0051294~establishment of spindle orientation, GO:0000137~Golgi cis cisterna,GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005886~plasma membrane,GO:0016323~basolateral plasma membrane,GO:0030424~axon,GO:0030864~cortical actin cytoskeleton,GO:0031901~early endosome membrane,GO:0032588~trans-Golgi network membrane,GO:0035748~myelin sheath abaxonal region, GO:0005096~GTPase activator activity,GO:0017137~Rab GTPase binding,GO:0019901~protein kinase binding,GO:0019905~syntaxin binding, IPR000664:Lethal(2) giant larvae protein,IPR001680:WD40 repeat,IPR013577:Lethal giant larvae homologue 2,IPR013905:Lethal giant larvae (Lgl)-like, C-terminal,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site, rno04390:Hippo signaling pathway,rno04530:Tight junction, SM00320:WD40, Cell projection,Complete proteome,Cytoplasm,Cytoskeleton,Endosome,Exocytosis,Golgi apparatus,Membrane,Phosphoprotein,Reference proteome,Repeat,WD repeat, chain:Lethal(2) giant larvae protein homolog 1,modified residue,repeat:WD 1,repeat:WD 10,repeat:WD 11,repeat:WD 12,repeat:WD 13,repeat:WD 14,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,repeat:WD 8,repeat:WD 9, Q00174 Laminin A(LanA) Drosophila melanogaster GO:0001964~startle response,GO:0002121~inter-male aggressive behavior,GO:0007411~axon guidance,GO:0007476~imaginal disc-derived wing morphogenesis,GO:0007498~mesoderm development,GO:0007507~heart development,GO:0010906~regulation of glucose metabolic process,GO:0016321~female meiosis chromosome segregation,GO:0030155~regulation of cell adhesion,GO:0030334~regulation of cell migration,GO:0031987~locomotion involved in locomotory behavior,GO:0033627~cell adhesion mediated by integrin,GO:0034446~substrate adhesion-dependent cell spreading,GO:0035001~dorsal trunk growth, open tracheal system,GO:0035011~melanotic encapsulation of foreign target,GO:0045886~negative regulation of synaptic growth at neuromuscular junction,GO:0045995~regulation of embryonic development,GO:0048854~brain morphogenesis, GO:0005604~basement membrane,GO:0005605~basal lamina,GO:0008021~synaptic vesicle,GO:0030054~cell junction,GO:0030424~axon,GO:0036062~presynaptic periactive zone, GO:0005102~receptor binding, IPR000034:Laminin B type IV,IPR000742:Epidermal growth factor-like domain,IPR001791:Laminin G domain,IPR002049:EGF-like, laminin,IPR008211:Laminin, N-terminal,IPR009254:Laminin I,IPR010307:Laminin II,IPR011641:Tyrosine-protein kinase ephrin type A/B receptor-like,IPR013032:EGF-like, conserved site,IPR013320:Concanavalin A-like lectin/glucanase, subgroup, dme04512:ECM-receptor interaction, SM00136:LamNT,SM00180:EGF_Lam,SM00181:EGF,SM00281:LamB,SM00282:LamG,SM01411:SM01411, Basement membrane,Cell adhesion,Cell junction,Cell projection,Coiled coil,Complete proteome,Cytoplasmic vesicle,Disulfide bond,Extracellular matrix,Glycoprotein,Laminin EGF-like domain,Reference proteome,Repeat,Secreted,Signal,Synapse, chain:Laminin subunit alpha,compositionally biased region:Poly-Thr,disulfide bond,domain:Laminin EGF-like 1,domain:Laminin EGF-like 10,domain:Laminin EGF-like 11; truncated,domain:Laminin EGF-like 12,domain:Laminin EGF-like 13,domain:Laminin EGF-like 14,domain:Laminin EGF-like 15,domain:Laminin EGF-like 16; first part,domain:Laminin EGF-like 16; second part,domain:Laminin EGF-like 17,domain:Laminin EGF-like 18,domain:Laminin EGF-like 19,domain:Laminin EGF-like 2,domain:Laminin EGF-like 20,domain:Laminin EGF-like 21,domain:Laminin EGF-like 22,domain:Laminin EGF-like 3,domain:Laminin EGF-like 4,domain:Laminin EGF-like 5,domain:Laminin EGF-like 6,domain:Laminin EGF-like 7,domain:Laminin EGF-like 8,domain:Laminin EGF-like 9,domain:Laminin G-like 1,domain:Laminin G-like 2,domain:Laminin G-like 3,domain:Laminin G-like 4,domain:Laminin G-like 5,domain:Laminin IV type A,domain:Laminin N-terminal,glycosylation site:N-linked (GlcNAc...),region of interest:Domain II and I,region of interest:Domain IV'',sequence conflict,signal peptide, A5D9C6 MAF1 homolog, negative regulator of RNA polymerase III(MAF1) Bos taurus GO:0006351~transcription, DNA-templated,GO:0016480~negative regulation of transcription from RNA polymerase III promoter,GO:0070217~transcription factor TFIIIB complex assembly, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005813~centrosome, GO:0000994~RNA polymerase III core binding,GO:0001030~RNA polymerase III type 1 promoter DNA binding,GO:0001031~RNA polymerase III type 2 promoter DNA binding,GO:0001032~RNA polymerase III type 3 promoter DNA binding, IPR015257:Maf1 regulator, PIRSF037240:repressor of RNA polymerase III transcription MAF1, Complete proteome,Cytoplasm,Isopeptide bond,Nucleus,Phosphoprotein,Reference proteome,Repressor,Transcription,Transcription regulation,Ubl conjugation, Q6PGU2 MAF1 homolog, negative regulator of RNA polymerase III(maf1) Danio rerio GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0016480~negative regulation of transcription from RNA polymerase III promoter,GO:0070217~transcription factor TFIIIB complex assembly, GO:0005634~nucleus,GO:0005737~cytoplasm, GO:0000994~RNA polymerase III core binding, IPR015257:Maf1 regulator, PIRSF037240:repressor of RNA polymerase III transcription MAF1, Complete proteome,Cytoplasm,Nucleus,Reference proteome,Repressor,Transcription,Transcription regulation, chain:Repressor of RNA polymerase III transcription MAF1 homolog, Q9UDY8 MALT1 paracaspase(MALT1) Homo sapiens GO:0001923~B-1 B cell differentiation,GO:0002223~stimulatory C-type lectin receptor signaling pathway,GO:0002237~response to molecule of bacterial origin,GO:0002726~positive regulation of T cell cytokine production,GO:0006508~proteolysis,GO:0006952~defense response,GO:0007250~activation of NF-kappaB-inducing kinase activity,GO:0009620~response to fungus,GO:0016567~protein ubiquitination,GO:0031398~positive regulation of protein ubiquitination,GO:0032743~positive regulation of interleukin-2 production,GO:0038095~Fc-epsilon receptor signaling pathway,GO:0042098~T cell proliferation,GO:0042981~regulation of apoptotic process,GO:0043066~negative regulation of apoptotic process,GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling,GO:0045087~innate immune response,GO:0050852~T cell receptor signaling pathway,GO:0050856~regulation of T cell receptor signaling pathway,GO:0050870~positive regulation of T cell activation,GO:0051092~positive regulation of NF-kappaB transcription factor activity,GO:0051168~nuclear export,GO:0051259~protein oligomerization, GO:0005634~nucleus,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0032449~CBM complex,GO:0043234~protein complex,GO:0048471~perinuclear region of cytoplasm, GO:0002020~protease binding,GO:0004197~cysteine-type endopeptidase activity,GO:0004842~ubiquitin-protein transferase activity,GO:0004871~signal transducer activity,GO:0005515~protein binding,GO:0008233~peptidase activity,GO:0019209~kinase activator activity,GO:0043621~protein self-association, IPR001309:Peptidase C14, ICE, catalytic subunit p20,IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR007110:Immunoglobulin-like domain,IPR011029:Death-like domain,IPR013783:Immunoglobulin-like fold, hsa04064:NF-kappa B signaling pathway,hsa04660:T cell receptor signaling pathway,hsa04662:B cell receptor signaling pathway,hsa05152:Tuberculosis, 615468~Immunodeficiency 12, SM00408:IGc2,SM00409:IG, 3D-structure,Acetylation,Alternative splicing,Chromosomal rearrangement,Complete proteome,Cytoplasm,Disease mutation,Disulfide bond,Hydrolase,Immunoglobulin domain,Nucleus,Phosphoprotein,Polymorphism,Protease,Proteomics identification,Reference proteome,Repeat,Ubl conjugation pathway, chain:Mucosa-associated lymphoid tissue lymphoma translocation protein 1,disulfide bond,domain:Death,domain:Ig-like C2-type 1,domain:Ig-like C2-type 2,helix,modified residue,mutagenesis site,region of interest:Caspase-like,sequence variant,short sequence motif:Nuclear export signal,site:Breakpoint for translocation to form BIRC2-MALT1,splice variant, Q63406 MCF.2 cell line derived transforming sequence-like(Mcf2l) Rattus norvegicus GO:0007266~Rho protein signal transduction,GO:0035023~regulation of Rho protein signal transduction,GO:0035025~positive regulation of Rho protein signal transduction,GO:0035556~intracellular signal transduction,GO:0043547~positive regulation of GTPase activity,GO:0045944~positive regulation of transcription from RNA polymerase II promoter, GO:0005615~extracellular space,GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0012505~endomembrane system,GO:0016020~membrane,GO:0019898~extrinsic component of membrane,GO:0030027~lamellipodium,GO:0031234~extrinsic component of cytoplasmic side of plasma membrane, GO:0005089~Rho guanyl-nucleotide exchange factor activity,GO:0005545~1-phosphatidylinositol binding,GO:0008289~lipid binding,GO:0035091~phosphatidylinositol binding, IPR000219:Dbl homology (DH) domain,IPR001251:CRAL-TRIO domain,IPR001331:Guanine-nucleotide dissociation stimulator, CDC24, conserved site,IPR001452:Src homology-3 domain,IPR001849:Pleckstrin homology domain,IPR002017:Spectrin repeat,IPR011993:Pleckstrin homology-like domain,IPR018159:Spectrin/alpha-actinin, SM00150:SPEC,SM00233:PH,SM00325:RhoGEF,SM00326:SH3,SM00516:SEC14, Cell membrane,Coiled coil,Complete proteome,Cytoplasm,Guanine-nucleotide releasing factor,Lipid-binding,Membrane,Phosphoprotein,Proto-oncogene,Reference proteome,SH3 domain,Signal, chain:Guanine nucleotide exchange factor DBS,compositionally biased region:Poly-Glu,domain:CRAL-TRIO,domain:DH,domain:PH,helix,modified residue,strand,turn, Q7ZXZ0 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)(mcm3) Xenopus laevis GO:0006270~DNA replication initiation,GO:0007049~cell cycle,GO:0030174~regulation of DNA-dependent DNA replication initiation, GO:0005634~nucleus,GO:0042555~MCM complex, GO:0003677~DNA binding,GO:0003678~DNA helicase activity,GO:0005524~ATP binding, IPR001208:Mini-chromosome maintenance, DNA-dependent ATPase,IPR003593:AAA+ ATPase domain,IPR008046:DNA replication licensing factor Mcm3,IPR012340:Nucleic acid-binding, OB-fold,IPR018525:Mini-chromosome maintenance, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, xla03030:DNA replication,xla04110:Cell cycle, SM00350:MCM,SM00382:AAA, ATP-binding,Cell cycle,DNA replication,DNA-binding,Helicase,Hydrolase,Nucleotide-binding,Nucleus, chain:Zygotic DNA replication licensing factor mcm3,domain:MCM,nucleotide phosphate-binding region:ATP, Q0VC16 MIA family member 3, ER export factor(MIA3) Bos taurus GO:0002687~positive regulation of leukocyte migration,GO:0006887~exocytosis,GO:0006888~ER to Golgi vesicle-mediated transport,GO:0007162~negative regulation of cell adhesion,GO:0015031~protein transport,GO:0030336~negative regulation of cell migration,GO:0042060~wound healing,GO:0042953~lipoprotein transport,GO:0090110~cargo loading into COPII-coated vesicle, GO:0000139~Golgi membrane,GO:0005789~endoplasmic reticulum membrane,GO:0016021~integral component of membrane,GO:0070971~endoplasmic reticulum exit site, GO:0042954~lipoprotein transporter activity, IPR001452:Src homology-3 domain,IPR011511:Variant SH3, SM00326:SH3, Coiled coil,Complete proteome,Endoplasmic reticulum,ER-Golgi transport,Exocytosis,Glycoprotein,Membrane,Methylation,Phosphoprotein,Protein transport,Proteomics identification,Reference proteome,SH3 domain,Signal,Transmembrane,Transmembrane helix,Transport, chain:Melanoma inhibitory activity protein 3,compositionally biased region:Pro-rich,domain:SH3,glycosylation site:N-linked (GlcNAc...),modified residue,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,topological domain:In membrane,transmembrane region, Q7Z3U7 MON2 homolog, regulator of endosome-to-Golgi trafficking(MON2) Homo sapiens GO:0006895~Golgi to endosome transport,GO:0015031~protein transport,GO:0015986~ATP synthesis coupled proton transport, GO:0000276~mitochondrial proton-transporting ATP synthase complex, coupling factor F(o),GO:0005829~cytosol,GO:0016021~integral component of membrane,GO:0070062~extracellular exosome, GO:0005515~protein binding,GO:0015078~hydrogen ion transmembrane transporter activity, IPR001421:ATPase, F0 complex, subunit 8, mitochondrial, Metazoan,IPR011989:Armadillo-like helical,IPR015403:Domain of unknown function DUF1981, SEC7 associated,IPR016024:Armadillo-type fold, Acetylation,Alternative splicing,ATP synthesis,CF(0),Complete proteome,Hydrogen ion transport,Ion transport,Membrane,Mitochondrion,Phosphoprotein,Polymorphism,Protein transport,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix,Transport, chain:Protein MON2 homolog,modified residue,sequence conflict,sequence variant,splice variant, Q14149 MORC family CW-type zinc finger 3(MORC3) Homo sapiens GO:0006468~protein phosphorylation,GO:0007569~cell aging,GO:0009791~post-embryonic development,GO:0016032~viral process,GO:0018105~peptidyl-serine phosphorylation,GO:0048147~negative regulation of fibroblast proliferation,GO:0050821~protein stabilization,GO:0051457~maintenance of protein location in nucleus, GO:0005654~nucleoplasm,GO:0016363~nuclear matrix,GO:0016605~PML body, GO:0003723~RNA binding,GO:0008270~zinc ion binding, IPR003594:Histidine kinase-like ATPase, ATP-binding domain,IPR011124:Zinc finger, CW-type, 3D-structure,Coiled coil,Complete proteome,Host-virus interaction,Isopeptide bond,Metal-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,RNA-binding,Ubl conjugation,Zinc,Zinc-finger, chain:MORC family CW-type zinc finger protein 3,zinc finger region:CW-type, Q5T089 MORN repeat containing 1(MORN1) Homo sapiens Function unknown, IPR003409:MORN motif, SM00698:MORN, Alternative splicing,Complete proteome,Polymorphism,Reference proteome,Repeat, chain:MORN repeat-containing protein 1,repeat:MORN 1,repeat:MORN 2,repeat:MORN 3,repeat:MORN 4,repeat:MORN 5,repeat:MORN 6,repeat:MORN 7,sequence variant,splice variant, Q9JI70 McKusick-Kaufman syndrome(Mkks) Mus musculus GO:0006457~protein folding,GO:0007286~spermatid development,GO:0007608~sensory perception of smell,GO:0010629~negative regulation of gene expression,GO:0014824~artery smooth muscle contraction,GO:0021756~striatum development,GO:0021766~hippocampus development,GO:0021987~cerebral cortex development,GO:0030837~negative regulation of actin filament polymerization,GO:0033210~leptin-mediated signaling pathway,GO:0034260~negative regulation of GTPase activity,GO:0035058~nonmotile primary cilium assembly,GO:0035176~social behavior,GO:0038108~negative regulation of appetite by leptin-mediated signaling pathway,GO:0040018~positive regulation of multicellular organism growth,GO:0042311~vasodilation,GO:0042384~cilium assembly,GO:0044321~response to leptin,GO:0045444~fat cell differentiation,GO:0045494~photoreceptor cell maintenance,GO:0045776~negative regulation of blood pressure,GO:0048854~brain morphogenesis,GO:0050910~detection of mechanical stimulus involved in sensory perception of sound,GO:0051131~chaperone-mediated protein complex assembly,GO:0051216~cartilage development,GO:0051492~regulation of stress fiber assembly,GO:0060271~cilium morphogenesis,GO:0060296~regulation of cilium beat frequency involved in ciliary motility,GO:0060324~face development, GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005829~cytosol,GO:0005856~cytoskeleton,GO:0031514~motile cilium,GO:0036064~ciliary basal body,GO:1902636~kinociliary basal body, GO:0000166~nucleotide binding,GO:0001103~RNA polymerase II repressing transcription factor binding,GO:0005524~ATP binding,GO:0051082~unfolded protein binding, IPR002423:Chaperonin Cpn60/TCP-1,IPR027409:GroEL-like apical domain,IPR027413:GroEL-like equatorial domain, ATP-binding,Chaperone,Complete proteome,Cytoplasm,Cytoskeleton,Nucleotide-binding,Reference proteome, chain:McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin,nucleotide phosphate-binding region:ATP, Q5ZKD7 Mov10, Moloney leukemia virus 10, homolog (mouse)(MOV10) Gallus gallus DNA replication, recombination, and repair, GO:0035195~gene silencing by miRNA,GO:0035279~mRNA cleavage involved in gene silencing by miRNA, GO:0000932~cytoplasmic mRNA processing body,GO:0005615~extracellular space, GO:0003723~RNA binding,GO:0004386~helicase activity,GO:0005524~ATP binding,GO:0044822~poly(A) RNA binding, IPR026122:Putative helicase MOV-10/Armitage,IPR027417:P-loop containing nucleoside triphosphate hydrolase, ATP-binding,Complete proteome,Cytoplasm,Helicase,Hydrolase,Nucleotide-binding,Reference proteome,RNA-binding,RNA-mediated gene silencing, chain:Putative helicase MOV-10,nucleotide phosphate-binding region:ATP,short sequence motif:DEAG box, Q9D7V9 N-acylethanolamine acid amidase(Naaa) Mus musculus GO:0006629~lipid metabolic process, GO:0005737~cytoplasm,GO:0005764~lysosome,GO:0070062~extracellular exosome, GO:0008134~transcription factor binding,GO:0016787~hydrolase activity,GO:0016810~hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, IPR016699:Acid ceramidase-like, PIRSF017632:acid ceramidase, Autocatalytic cleavage,Complete proteome,Glycoprotein,Hydrolase,Lysosome,Proteomics identification,Reference proteome,Signal,Zymogen, chain:N-acylethanolamine-hydrolyzing acid amidase,glycosylation site:N-linked (GlcNAc...),sequence conflict,signal peptide, Q1HPL8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 10(LOC733018) Bombyx mori GO:0055114~oxidation-reduction process, GO:0005743~mitochondrial inner membrane,GO:0070469~respiratory chain, IPR019377:NADH-ubiquinone oxidoreductase, subunit 10, Complete proteome,Direct protein sequencing,Electron transport,Membrane,Mitochondrion,Mitochondrion inner membrane,Reference proteome,Respiratory chain,Transport, chain:NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, P50365 NADH dehydrogenase, subunit 5(nad5) Allomyces macrogynus GO:0042773~ATP synthesis coupled electron transport, GO:0005743~mitochondrial inner membrane,GO:0016021~integral component of membrane,GO:0070469~respiratory chain, GO:0008137~NADH dehydrogenase (ubiquinone) activity, IPR001516:NADH:ubiquinone oxidoreductase, chain 5/L, N-terminal,IPR001750:NADH:ubiquinone/plastoquinone oxidoreductase,IPR003945:NADH-plastoquinone oxidoreductase, chain 5,IPR010934:NADH dehydrogenase subunit 5, C-terminal,IPR018393:NADH-plastoquinone oxidoreductase, chain 5 subgroup, Electron transport,Membrane,Mitochondrion,Mitochondrion inner membrane,NAD,Oxidoreductase,Respiratory chain,Transmembrane,Transmembrane helix,Transport,Ubiquinone, chain:NADH-ubiquinone oxidoreductase chain 5,transmembrane region, Q5RDE7 NFS1, cysteine desulfurase(NFS1) Pongo abelii Posttranslational modification, protein turnover, chaperones, GO:0006777~Mo-molybdopterin cofactor biosynthetic process,GO:0018283~iron incorporation into metallo-sulfur cluster,GO:0044571~[2Fe-2S] cluster assembly, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0005739~mitochondrion,GO:0005759~mitochondrial matrix,GO:0005829~cytosol, GO:0030170~pyridoxal phosphate binding,GO:0031071~cysteine desulfurase activity,GO:0046872~metal ion binding,GO:0051536~iron-sulfur cluster binding, IPR000192:Aminotransferase, class V/Cysteine desulfurase,IPR010240:Cysteine desulfurase,IPR015421:Pyridoxal phosphate-dependent transferase, major region, subdomain 1,IPR015422:Pyridoxal phosphate-dependent transferase, major region, subdomain 2,IPR015424:Pyridoxal phosphate-dependent transferase,IPR016454:Cysteine desulfurase, NifS,IPR020578:Aminotransferase class-V pyridoxal-phosphate binding site, pon00730:Thiamine metabolism,pon01100:Metabolic pathways,pon04122:Sulfur relay system, PIRSF005572:cysteine desulfurase, NifS type, Alternative initiation,Complete proteome,Cytoplasm,Iron,Iron-sulfur,Metal-binding,Mitochondrion,Molybdenum cofactor biosynthesis,Nucleus,Pyridoxal phosphate,Reference proteome,Transferase,Transit peptide, chain:Cysteine desulfurase, mitochondrial,modified residue,splice variant,transit peptide:Mitochondrion, Q86SG6 NIMA related kinase 8(NEK8) Homo sapiens Cell division and chromosome partitioning / Cytoskeleton, GO:0006468~protein phosphorylation,GO:0007368~determination of left/right symmetry,GO:0007507~heart development,GO:0009887~organ morphogenesis,GO:0035330~regulation of hippo signaling, GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005929~cilium,GO:0072372~primary cilium,GO:0097543~ciliary inversin compartment,GO:0097546~ciliary base, GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0046872~metal ion binding, IPR000408:Regulator of chromosome condensation, RCC1,IPR000719:Protein kinase, catalytic domain,IPR008271:Serine/threonine-protein kinase, active site,IPR009091:Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, 613824~Nephronophthisis 9,615415~Renal-hepatic-pancreatic dysplasia 2, SM00220:S_TKc, ATP-binding,Cell projection,Ciliopathy,Cilium,Complete proteome,Cytoplasm,Cytoskeleton,Disease mutation,Kinase,Magnesium,Metal-binding,Nephronophthisis,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Serine/threonine-protein kinase,Transferase, active site:Proton acceptor,binding site:ATP,chain:Serine/threonine-protein kinase Nek8,domain:Protein kinase,modified residue,nucleotide phosphate-binding region:ATP,repeat:RCC1 1,repeat:RCC1 2,repeat:RCC1 3,repeat:RCC1 4,repeat:RCC1 5, Q15155 NODAL modulator 1(NOMO1) Homo sapiens Cell envelope biogenesis, outer membrane, GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0030246~carbohydrate binding, IPR008969:Carboxypeptidase-like, regulatory domain,IPR013783:Immunoglobulin-like fold,IPR013784:Carbohydrate-binding-like fold,IPR014766:Carboxypeptidase, regulatory domain, Complete proteome,Glycoprotein,Membrane,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Signal,Transmembrane,Transmembrane helix, chain:Nodal modulator 1,chain:Nodal modulator 2,chain:Nodal modulator 3,glycosylation site:N-linked (GlcNAc...),modified residue,sequence conflict,sequence variant,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,topological domain:Lumenal,transmembrane region, Q8K4F6 NOL1/NOP2/Sun domain family, member 5(Nsun5) Mus musculus GO:0006364~rRNA processing,GO:0032259~methylation,GO:0070475~rRNA base methylation, GO:0005634~nucleus,GO:0005730~nucleolus, GO:0003723~RNA binding,GO:0008168~methyltransferase activity,GO:0008173~RNA methyltransferase activity,GO:0008757~S-adenosylmethionine-dependent methyltransferase activity,GO:0016740~transferase activity,GO:0044822~poly(A) RNA binding, IPR001678:Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p,IPR023267:RNA (C5-cytosine) methyltransferase, Acetylation,Complete proteome,Methyltransferase,Phosphoprotein,Proteomics identification,Reference proteome,RNA-binding,rRNA processing,S-adenosyl-L-methionine,Transferase, active site:Nucleophile,binding site:S-adenosyl-L-methionine,chain:Putative methyltransferase NSUN5,modified residue,region of interest:S-adenosyl-L-methionine binding,sequence conflict, P20241 Neuroglian(Nrg) Drosophila melanogaster GO:0007158~neuron cell-cell adhesion,GO:0007173~epidermal growth factor receptor signaling pathway,GO:0007409~axonogenesis,GO:0007560~imaginal disc morphogenesis,GO:0008045~motor neuron axon guidance,GO:0008049~male courtship behavior,GO:0008050~female courtship behavior,GO:0008366~axon ensheathment,GO:0016319~mushroom body development,GO:0019991~septate junction assembly,GO:0021682~nerve maturation,GO:0035011~melanotic encapsulation of foreign target,GO:0035151~regulation of tube size, open tracheal system,GO:0045924~regulation of female receptivity,GO:0048036~central complex development,GO:0048675~axon extension,GO:0048812~neuron projection morphogenesis,GO:0048813~dendrite morphogenesis,GO:0050808~synapse organization,GO:0060857~establishment of glial blood-brain barrier,GO:0061343~cell adhesion involved in heart morphogenesis,GO:0072499~photoreceptor cell axon guidance, GO:0005886~plasma membrane,GO:0005918~septate junction,GO:0005919~pleated septate junction,GO:0005923~bicellular tight junction,GO:0016021~integral component of membrane,GO:0016328~lateral plasma membrane,GO:0030175~filopodium,GO:0035230~cytoneme, GO:0005509~calcium ion binding, IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR003961:Fibronectin, type III,IPR007110:Immunoglobulin-like domain,IPR013098:Immunoglobulin I-set,IPR013151:Immunoglobulin,IPR013783:Immunoglobulin-like fold,IPR026966:Fibronectin type III C-terminal domain, SM00060:FN3,SM00408:IGc2,SM00409:IG, 3D-structure,Alternative splicing,Cell adhesion,Cell junction,Cell membrane,Complete proteome,Developmental protein,Direct protein sequencing,Disulfide bond,Glycoprotein,Immunoglobulin domain,Membrane,Proteomics identification,Reference proteome,Repeat,Signal,Tight junction,Transmembrane,Transmembrane helix, chain:Neuroglian,disulfide bond,domain:Fibronectin type-III 1,domain:Fibronectin type-III 2,domain:Fibronectin type-III 3,domain:Fibronectin type-III 4,domain:Fibronectin type-III 5,domain:Ig-like C2-type 1,domain:Ig-like C2-type 2,domain:Ig-like C2-type 3,domain:Ig-like C2-type 4,domain:Ig-like C2-type 5,domain:Ig-like C2-type 6,glycosylation site:N-linked (GlcNAc...),helix,sequence conflict,signal peptide,splice variant,strand,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, O75665 OFD1, centriole and centriolar satellite protein(OFD1) Homo sapiens GO:0000086~G2/M transition of mitotic cell cycle,GO:0007067~mitotic nuclear division,GO:0007099~centriole replication,GO:0060271~cilium morphogenesis,GO:0060287~epithelial cilium movement involved in determination of left/right asymmetry,GO:0090307~mitotic spindle assembly, GO:0005634~nucleus,GO:0005813~centrosome,GO:0005814~centriole,GO:0005829~cytosol,GO:0005929~cilium,GO:0015630~microtubule cytoskeleton,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0034451~centriolar satellite,GO:0036064~ciliary basal body, GO:0005515~protein binding,GO:0042802~identical protein binding,GO:0043014~alpha-tubulin binding,GO:0043015~gamma-tubulin binding, IPR006594:LisH dimerisation motif, 300209~Simpson-Golabi-Behmel syndrome, type 2,300424~Retinitis pigmentosa 23,300804~Joubert syndrome 10,311200~Orofaciodigital syndrome I, SM00667:LisH, Alternative splicing,Cell projection,Ciliopathy,Cilium,Cilium biogenesis/degradation,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Disease mutation,Joubert syndrome,Membrane,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Retinitis pigmentosa,Transmembrane,Transmembrane helix, chain:Oral-facial-digital syndrome 1 protein,domain:LisH,modified residue,sequence variant,splice variant, Q7ZV00 OTU domain containing 6B(otud6b) Danio rerio Posttranslational modification, protein turnover, chaperones, GO:0006508~proteolysis, GO:0008233~peptidase activity,GO:0008234~cysteine-type peptidase activity,GO:0016787~hydrolase activity,GO:0036459~thiol-dependent ubiquitinyl hydrolase activity, IPR003323:Ovarian tumour, otubain, Coiled coil,Complete proteome,Hydrolase,Protease,Reference proteome,Thiol protease,Ubl conjugation pathway, chain:OTU domain-containing protein 6B,domain:OTU, Q9VCA2 Organic cation transporter(Orct) Drosophila melanogaster GO:0006811~ion transport,GO:0006915~apoptotic process,GO:0015695~organic cation transport,GO:0055085~transmembrane transport, GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane, GO:0015101~organic cation transmembrane transporter activity,GO:0022857~transmembrane transporter activity,GO:0022891~substrate-specific transmembrane transporter activity, IPR005828:General substrate transporter,IPR020846:Major facilitator superfamily domain, Complete proteome,Glycoprotein,Ion transport,Membrane,Reference proteome,Transmembrane,Transmembrane helix,Transport, chain:Organic cation transporter protein,glycosylation site:N-linked (GlcNAc...),sequence conflict,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q8BGF7 PAN2 poly(A) specific ribonuclease subunit(Pan2) Mus musculus GO:0000289~nuclear-transcribed mRNA poly(A) tail shortening,GO:0000291~nuclear-transcribed mRNA catabolic process, exonucleolytic,GO:0006397~mRNA processing,GO:0010606~positive regulation of cytoplasmic mRNA processing body assembly, GO:0000932~cytoplasmic mRNA processing body,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0031251~PAN complex, GO:0000175~3'-5'-exoribonuclease activity,GO:0003676~nucleic acid binding,GO:0004518~nuclease activity,GO:0004527~exonuclease activity,GO:0004535~poly(A)-specific ribonuclease activity,GO:0005515~protein binding,GO:0016787~hydrolase activity, IPR012337:Ribonuclease H-like domain,IPR013520:Exonuclease, RNase T/DNA polymerase III,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain, mmu03018:RNA degradation, SM00479:EXOIII, Alternative splicing,Complete proteome,Cytoplasm,Exonuclease,Hydrolase,mRNA processing,Nuclease,Nucleus,Phosphoprotein,Reference proteome,Repeat,WD repeat, chain:PAB-dependent poly(A)-specific ribonuclease subunit 2,domain:Exonuclease,modified residue,sequence conflict,splice variant, B5DF93 PAT1 homolog 1, processing body mRNA decay factor(Patl1) Rattus norvegicus GO:0000290~deadenylation-dependent decapping of nuclear-transcribed mRNA,GO:0033962~cytoplasmic mRNA processing body assembly, GO:0000932~cytoplasmic mRNA processing body,GO:0016605~PML body,GO:0016607~nuclear speck,GO:0030014~CCR4-NOT complex,GO:0043231~intracellular membrane-bounded organelle, GO:0003723~RNA binding,GO:0008266~poly(U) RNA binding,GO:0034046~poly(G) binding,GO:0044822~poly(A) RNA binding, IPR019167:Topoisomerase II-associated protein PAT1, rno03018:RNA degradation, Complete proteome,Cytoplasm,Methylation,Nucleus,Phosphoprotein,Reference proteome,RNA-binding, Q69ZS0 PDZ domain containing RING finger 3(Pdzrn3) Mus musculus GO:0007528~neuromuscular junction development,GO:0016567~protein ubiquitination, GO:0031594~neuromuscular junction, GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0046872~metal ion binding,GO:0061630~ubiquitin protein ligase activity, IPR001293:Zinc finger, TRAF-type,IPR001478:PDZ domain,IPR001841:Zinc finger, RING-type,IPR008974:TRAF-like,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR013323:SIAH-type domain,IPR017907:Zinc finger, RING-type, conserved site, SM00184:RING,SM00228:PDZ, Alternative splicing,Coiled coil,Complete proteome,Ligase,Metal-binding,Phosphoprotein,Reference proteome,Repeat,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, chain:PDZ domain-containing RING finger protein 3,compositionally biased region:Poly-Arg,domain:PDZ 1,domain:PDZ 2,sequence conflict,splice variant,zinc finger region:RING-type; degenerate,zinc finger region:TRAF-type, Q9D4J7 PHD finger protein 6(Phf6) Mus musculus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0000775~chromosome, centromeric region,GO:0000776~kinetochore,GO:0000777~condensed chromosome kinetochore,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005694~chromosome,GO:0005730~nucleolus, GO:0003677~DNA binding,GO:0008270~zinc ion binding,GO:0015631~tubulin binding,GO:0019899~enzyme binding,GO:0042393~histone binding,GO:0042826~histone deacetylase binding,GO:0043021~ribonucleoprotein complex binding,GO:0044822~poly(A) RNA binding,GO:0046872~metal ion binding,GO:0051219~phosphoprotein binding,GO:0097110~scaffold protein binding, IPR001965:Zinc finger, PHD-type, SM00249:PHD, Acetylation,Alternative splicing,Centromere,Chromosome,Complete proteome,DNA-binding,Isopeptide bond,Kinetochore,Metal-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,Ubl conjugation,Zinc,Zinc-finger, chain:PHD finger protein 6,modified residue,short sequence motif:Nuclear localization signal,short sequence motif:Nucleolar localization signal,splice variant,zinc finger region:PHD-type 1; degenerate,zinc finger region:PHD-type 2; degenerate, Q8TF01 PNN interacting serine and arginine rich protein(PNISR) Homo sapiens GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0016607~nuclear speck, GO:0044822~poly(A) RNA binding, Alternative splicing,Coiled coil,Complete proteome,Isopeptide bond,Nucleus,Phosphoprotein,Reference proteome,Ubl conjugation, chain:Splicing factor, arginine/serine-rich 18,compositionally biased region:Gln-rich,compositionally biased region:Pro-rich,compositionally biased region:Ser-rich,modified residue,sequence conflict,splice variant, Q7SXM7 PRP31 pre-mRNA processing factor 31 homolog (yeast)(prpf31) Danio rerio GO:0000244~spliceosomal tri-snRNP complex assembly,GO:0000398~mRNA splicing, via spliceosome,GO:0006397~mRNA processing,GO:0008380~RNA splicing,GO:0060041~retina development in camera-type eye, GO:0005634~nucleus,GO:0005681~spliceosomal complex,GO:0005687~U4 snRNP,GO:0005690~U4atac snRNP,GO:0030529~intracellular ribonucleoprotein complex,GO:0046540~U4/U6 x U5 tri-snRNP complex,GO:0071011~precatalytic spliceosome,GO:0071339~MLL1 complex,GO:0097526~spliceosomal tri-snRNP complex, GO:0003723~RNA binding, IPR002687:Nop domain,IPR012976:NOSIC,IPR019175:Prp31 C-terminal,IPR027105:U4/U6 small nuclear ribonucleoprotein Prp31, dre03040:Spliceosome, SM00931:SM00931, Coiled coil,Complete proteome,mRNA processing,mRNA splicing,Nucleus,Proteomics identification,Reference proteome,Ribonucleoprotein,RNA-binding,Spliceosome, chain:U4/U6 small nuclear ribonucleoprotein Prp31,domain:Nop,site:Interaction with U4 snRNA, P52034 Phosphofructokinase(Pfk) Drosophila melanogaster GO:0006002~fructose 6-phosphate metabolic process,GO:0006096~glycolytic process,GO:0007520~myoblast fusion,GO:0007525~somatic muscle development,GO:0009744~response to sucrose, GO:0005737~cytoplasm,GO:0005945~6-phosphofructokinase complex, GO:0003872~6-phosphofructokinase activity,GO:0005524~ATP binding,GO:0046872~metal ion binding, IPR000023:Phosphofructokinase domain,IPR009161:6-phosphofructokinase, eukaryotic type,IPR015912:Phosphofructokinase, conserved site,IPR022953:Phosphofructokinase, dme00010:Glycolysis / Gluconeogenesis,dme00030:Pentose phosphate pathway,dme00051:Fructose and mannose metabolism,dme00052:Galactose metabolism,dme01100:Metabolic pathways,dme01130:Biosynthesis of antibiotics,dme01200:Carbon metabolism,dme01230:Biosynthesis of amino acids,dme03018:RNA degradation, PIRSF000533:ATP-dependent phosphofructokinase, eukaryotic type, Allosteric enzyme,Alternative splicing,ATP-binding,Complete proteome,Cytoplasm,Glycolysis,Kinase,Magnesium,Metal-binding,Nucleotide-binding,Proteomics identification,Reference proteome,Transferase, active site:Proton acceptor,binding site:Substrate,chain:6-phosphofructokinase,nucleotide phosphate-binding region:ATP,sequence conflict,splice variant, O46043 Poly(ADP-ribose) glycohydrolase(Parg) Drosophila melanogaster GO:0005975~carbohydrate metabolic process,GO:0006342~chromatin silencing,GO:0006909~phagocytosis,GO:0009408~response to heat,GO:0030576~Cajal body organization,GO:0035065~regulation of histone acetylation,GO:0036099~female germ-line stem cell population maintenance,GO:0043484~regulation of RNA splicing,GO:0051457~maintenance of protein location in nucleus, GO:0005634~nucleus,GO:0005654~nucleoplasm, GO:0004649~poly(ADP-ribose) glycohydrolase activity, IPR007724:Poly(ADP-ribose) glycohydrolase, Complete proteome,Hydrolase,Phosphoprotein,Reference proteome, chain:Poly(ADP-ribose) glycohydrolase,modified residue, Q05609 Protein kinase superfamily protein(CTR1) Arabidopsis thaliana GO:0001666~response to hypoxia,GO:0009686~gibberellin biosynthetic process,GO:0009723~response to ethylene,GO:0009744~response to sucrose,GO:0009750~response to fructose,GO:0009873~ethylene-activated signaling pathway,GO:0010105~negative regulation of ethylene-activated signaling pathway,GO:0010182~sugar mediated signaling pathway,GO:0046777~protein autophosphorylation,GO:0048510~regulation of timing of transition from vegetative to reproductive phase,GO:0071281~cellular response to iron ion,GO:2000035~regulation of stem cell division,GO:2000069~regulation of post-embryonic root development, GO:0005634~nucleus,GO:0005789~endoplasmic reticulum membrane, GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0004712~protein serine/threonine/tyrosine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016301~kinase activity, IPR000719:Protein kinase, catalytic domain,IPR001245:Serine-threonine/tyrosine-protein kinase catalytic domain,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, ath04075:Plant hormone signal transduction, SM00220:S_TKc, 3D-structure,ATP-binding,Complete proteome,Ethylene signaling pathway,Kinase,Nucleotide-binding,Reference proteome,Serine/threonine-protein kinase,Transferase, active site:Proton acceptor,binding site:ATP,chain:Serine/threonine-protein kinase CTR1,compositionally biased region:Poly-Gly,domain:Protein kinase,mutagenesis site,nucleotide phosphate-binding region:ATP, Q9U489 Protein lin-41(lin-41) Caenorhabditis elegans GO:0000003~reproduction,GO:0002119~nematode larval development,GO:0006898~receptor-mediated endocytosis,GO:0006915~apoptotic process,GO:0007275~multicellular organism development,GO:0007276~gamete generation,GO:0008406~gonad development,GO:0009957~epidermal cell fate specification,GO:0010171~body morphogenesis,GO:0018991~oviposition,GO:0018996~molting cycle, collagen and cuticulin-based cuticle,GO:0040011~locomotion,GO:0040018~positive regulation of multicellular organism growth,GO:0040027~negative regulation of vulval development,GO:0040034~regulation of development, heterochronic,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process,GO:0044268~multicellular organismal protein metabolic process,GO:0045138~nematode male tail tip morphogenesis,GO:0045604~regulation of epidermal cell differentiation, GO:0005622~intracellular,GO:0005737~cytoplasm, GO:0004842~ubiquitin-protein transferase activity,GO:0008270~zinc ion binding,GO:0046872~metal ion binding, IPR000315:Zinc finger, B-box,IPR001258:NHL repeat,IPR001298:Filamin/ABP280 repeat,IPR003649:B-box, C-terminal,IPR011042:Six-bladed beta-propeller, TolB-like,IPR013017:NHL repeat, subgroup,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR017868:Filamin/ABP280 repeat-like, SM00336:BBOX,SM00502:BBC,SM00557:IG_FLMN, 3D-structure,Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Developmental protein,Metal-binding,Reference proteome,Repeat,Zinc,Zinc-finger, chain:Protein lin-41,compositionally biased region:Gln-rich,compositionally biased region:Poly-Pro,repeat:Filamin,repeat:NHL 1,repeat:NHL 2,repeat:NHL 3,repeat:NHL 4,repeat:NHL 5,repeat:NHL 6,splice variant,zinc finger region:B box-type; atypical,zinc finger region:RING-type, P35992 Protein tyrosine phosphatase 10D(Ptp10D) Drosophila melanogaster GO:0006470~protein dephosphorylation,GO:0007411~axon guidance,GO:0007417~central nervous system development,GO:0007424~open tracheal system development,GO:0007616~long-term memory,GO:0008045~motor neuron axon guidance, GO:0005886~plasma membrane,GO:0016021~integral component of membrane,GO:0030424~axon,GO:0045177~apical part of cell, GO:0004721~phosphoprotein phosphatase activity,GO:0004725~protein tyrosine phosphatase activity,GO:0005001~transmembrane receptor protein tyrosine phosphatase activity, IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR003595:Protein-tyrosine phosphatase, catalytic,IPR003961:Fibronectin, type III,IPR013783:Immunoglobulin-like fold,IPR016130:Protein-tyrosine phosphatase, active site, SM00060:FN3,SM00194:PTPc,SM00404:PTPc_motif, 3D-structure,Alternative splicing,Complete proteome,Developmental protein,Differentiation,Glycoprotein,Hydrolase,Membrane,Neurogenesis,Protein phosphatase,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, active site:Phosphocysteine intermediate,chain:Tyrosine-protein phosphatase 10D,domain:Fibronectin type-III 1,domain:Fibronectin type-III 10,domain:Fibronectin type-III 11,domain:Fibronectin type-III 12,domain:Fibronectin type-III 2,domain:Fibronectin type-III 3,domain:Fibronectin type-III 4,domain:Fibronectin type-III 5,domain:Fibronectin type-III 6,domain:Fibronectin type-III 7,domain:Fibronectin type-III 8,domain:Fibronectin type-III 9,domain:Tyrosine-protein phosphatase,glycosylation site:N-linked (GlcNAc...),sequence conflict,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, P35832 Protein tyrosine phosphatase 99A(Ptp99A) Drosophila melanogaster GO:0006470~protein dephosphorylation,GO:0007414~axonal defasciculation,GO:0007415~defasciculation of motor neuron axon,GO:0008045~motor neuron axon guidance,GO:0010906~regulation of glucose metabolic process, GO:0005886~plasma membrane,GO:0016021~integral component of membrane,GO:0030424~axon, GO:0004725~protein tyrosine phosphatase activity,GO:0005001~transmembrane receptor protein tyrosine phosphatase activity, IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR003595:Protein-tyrosine phosphatase, catalytic,IPR003961:Fibronectin, type III,IPR007110:Immunoglobulin-like domain,IPR013783:Immunoglobulin-like fold,IPR016130:Protein-tyrosine phosphatase, active site, SM00060:FN3,SM00194:PTPc,SM00404:PTPc_motif, Alternative splicing,Coiled coil,Complete proteome,Glycoprotein,Hydrolase,Membrane,Protein phosphatase,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, active site:Phosphocysteine intermediate,chain:Tyrosine-protein phosphatase 99A,compositionally biased region:Gln-rich,compositionally biased region:Poly-Ser,compositionally biased region:Ser-rich,domain:Fibronectin type-III 1,domain:Fibronectin type-III 2,domain:Fibronectin type-III 3,domain:Tyrosine-protein phosphatase 1,domain:Tyrosine-protein phosphatase 2,glycosylation site:N-linked (GlcNAc...),sequence conflict,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q12829 RAB40B, member RAS oncogene family(RAB40B) Homo sapiens GO:0007264~small GTPase mediated signal transduction,GO:0016567~protein ubiquitination,GO:0035556~intracellular signal transduction,GO:1990967~multi-organism toxin transport, GO:0005622~intracellular,GO:0005635~nuclear envelope,GO:0005886~plasma membrane,GO:0048471~perinuclear region of cytoplasm, GO:0005525~GTP binding, IPR001496:SOCS protein, C-terminal,IPR001806:Small GTPase superfamily,IPR005225:Small GTP-binding protein domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00253:SOCS,SM00969:SM00969, Cell membrane,Complete proteome,GTP-binding,Lipoprotein,Membrane,Nucleotide-binding,Palmitate,Prenylation,Reference proteome,Ubl conjugation pathway, chain:Ras-related protein Rab-40B,domain:SOCS box,lipid moiety-binding region:S-geranylgeranyl cysteine,lipid moiety-binding region:S-palmitoyl cysteine,nucleotide phosphate-binding region:GTP,sequence conflict, O75943 RAD17 checkpoint clamp loader component(RAD17) Homo sapiens h_atrbrcaPathway:Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, GO:0000076~DNA replication checkpoint,GO:0000077~DNA damage checkpoint,GO:0006260~DNA replication,GO:0006281~DNA repair,GO:0006974~cellular response to DNA damage stimulus,GO:0007049~cell cycle,GO:0007093~mitotic cell cycle checkpoint,GO:0008156~negative regulation of DNA replication,GO:0033314~mitotic DNA replication checkpoint,GO:0042325~regulation of phosphorylation,GO:1901796~regulation of signal transduction by p53 class mediator, GO:0000781~chromosome, telomeric region,GO:0000790~nuclear chromatin,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0031389~Rad17 RFC-like complex, GO:0003682~chromatin binding,GO:0003689~DNA clamp loader activity,GO:0005515~protein binding,GO:0005524~ATP binding, IPR004582:Checkpoint protein Rad17/Rad24,IPR018324:Checkpoint protein Rad24, fungi/metazoa,IPR027417:P-loop containing nucleoside triphosphate hydrolase, Alternative splicing,ATP-binding,Cell cycle,Complete proteome,DNA damage,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:Cell cycle checkpoint protein RAD17,modified residue,mutagenesis site,nucleotide phosphate-binding region:ATP,region of interest:Interaction with MCM7,sequence conflict,sequence variant,splice variant, Q9Y620 RAD54 homolog B (S. cerevisiae)(RAD54B) Homo sapiens GO:0000724~double-strand break repair via homologous recombination,GO:0006312~mitotic recombination,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007131~reciprocal meiotic recombination,GO:0032508~DNA duplex unwinding, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm, GO:0003677~DNA binding,GO:0003678~DNA helicase activity,GO:0003724~RNA helicase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0015616~DNA translocase activity, IPR000330:SNF2-related,IPR001650:Helicase, C-terminal,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa03440:Homologous recombination, 114500~Colon cancer, somatic,605027~Lymphoma, non-Hodgkin, somatic, SM00487:DEXDc,SM00490:HELICc, Alternative splicing,ATP-binding,Complete proteome,DNA damage,DNA repair,DNA-binding,Helicase,Hydrolase,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repressor,Transcription,Transcription regulation, chain:DNA repair and recombination protein RAD54B,domain:Helicase ATP-binding,domain:Helicase C-terminal,modified residue,nucleotide phosphate-binding region:ATP,sequence variant,short sequence motif:DEGH box, A4IHD2 RAD54-like 2(rad54l2) Xenopus tropicalis GO:0005634~nucleus, GO:0003677~DNA binding,GO:0004386~helicase activity,GO:0005524~ATP binding, IPR000330:SNF2-related,IPR001650:Helicase, C-terminal,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00487:DEXDc,SM00490:HELICc, ATP-binding,Coiled coil,Complete proteome,DNA-binding,Helicase,Hydrolase,Nucleotide-binding,Nucleus,Reference proteome,Repeat, chain:Helicase ARIP4,compositionally biased region:Glu-rich,domain:Helicase ATP-binding,domain:Helicase C-terminal,nucleotide phosphate-binding region:ATP,short sequence motif:DEAH box,short sequence motif:LXXLL motif 1,short sequence motif:LXXLL motif 2, Q96D71 RALBP1 associated Eps domain containing 1(REPS1) Homo sapiens GO:0005886~plasma membrane,GO:0005905~clathrin-coated pit, GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0017124~SH3 domain binding, IPR000261:EPS15 homology (EH),IPR002048:EF-hand domain,IPR011992:EF-hand-like domain,IPR018247:EF-Hand 1, calcium-binding site, SM00027:EH, Alternative splicing,Calcium,Coated pit,Coiled coil,Complete proteome,Membrane,Metal-binding,Phosphoprotein,Proteomics identification,Reference proteome,Repeat, chain:RalBP1-associated Eps domain-containing protein 1,compositionally biased region:Pro-rich,domain:EF-hand,domain:EH 1,domain:EH 2,modified residue,region of interest:Interaction with RALBP1,sequence conflict,splice variant, Q9ERU9 RAN binding protein 2(Ranbp2) Mus musculus m_ranbp2Pathway:Sumoylation by RanBP2 Regulates Transcriptional Repression,m_ranPathway:Cycling of Ran in nucleocytoplasmic transport, GO:0000413~protein peptidyl-prolyl isomerization,GO:0001975~response to amphetamine,GO:0006457~protein folding,GO:0006607~NLS-bearing protein import into nucleus,GO:0006810~transport,GO:0015031~protein transport,GO:0016925~protein sumoylation,GO:0033132~negative regulation of glucokinase activity,GO:0046907~intracellular transport,GO:0051028~mRNA transport,GO:0090526~regulation of gluconeogenesis involved in cellular glucose homeostasis, GO:0005622~intracellular,GO:0005634~nucleus,GO:0005635~nuclear envelope,GO:0005643~nuclear pore,GO:0005739~mitochondrion,GO:0005875~microtubule associated complex,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0031965~nuclear membrane,GO:0042405~nuclear inclusion body,GO:0044614~nuclear pore cytoplasmic filaments,GO:0044615~nuclear pore nuclear basket,GO:1990723~cytoplasmic periphery of the nuclear pore complex, GO:0003723~RNA binding,GO:0003755~peptidyl-prolyl cis-trans isomerase activity,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0008536~Ran GTPase binding,GO:0016874~ligase activity,GO:0019789~SUMO transferase activity,GO:0046872~metal ion binding, IPR000156:Ran binding domain,IPR001876:Zinc finger, RanBP2-type,IPR002130:Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain,IPR011990:Tetratricopeptide-like helical,IPR011993:Pleckstrin homology-like domain,IPR013026:Tetratricopeptide repeat-containing domain,IPR019734:Tetratricopeptide repeat,IPR020892:Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site,IPR022011:Nup358/RanBP2 E3 ligase domain, mmu03013:RNA transport, SM00028:TPR,SM00160:RanBD,SM00547:ZnF_RBZ, Acetylation,Complete proteome,Disulfide bond,Isopeptide bond,Ligase,Membrane,Metal-binding,Methylation,mRNA transport,Nuclear pore complex,Nucleus,Phosphoprotein,Protein transport,Reference proteome,Repeat,RNA-binding,TPR repeat,Translocation,Transmembrane,Transmembrane helix,Transport,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, chain:E3 SUMO-protein ligase RANBP2,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Ser,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO),domain:PPIase cyclophilin-type,domain:RanBD1 1,domain:RanBD1 2,domain:RanBD1 3,domain:RanBD1 4,modified residue,region of interest:2 X 50 AA approximate repeats,region of interest:Interaction with SUMO1,region of interest:Interaction with sumoylated RANGAP1,region of interest:Interaction with UBE2I,region of interest:Required for E3 SUMO-ligase activity,repeat:1,repeat:2,repeat:TPR 1,repeat:TPR 2,repeat:TPR 3,sequence conflict,zinc finger region:RanBP2-type 1,zinc finger region:RanBP2-type 2,zinc finger region:RanBP2-type 3,zinc finger region:RanBP2-type 4,zinc finger region:RanBP2-type 5,zinc finger region:RanBP2-type 6, O54963 RE1-silencing transcription factor(Rest) Rattus norvegicus General function prediction only, GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0002244~hematopoietic progenitor cell differentiation,GO:0006351~transcription, DNA-templated,GO:0006366~transcription from RNA polymerase II promoter,GO:0008285~negative regulation of cell proliferation,GO:0010629~negative regulation of gene expression,GO:0032348~negative regulation of aldosterone biosynthetic process,GO:0035690~cellular response to drug,GO:0043065~positive regulation of apoptotic process,GO:0043280~positive regulation of cysteine-type endopeptidase activity involved in apoptotic process,GO:0043922~negative regulation by host of viral transcription,GO:0045665~negative regulation of neuron differentiation,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0045955~negative regulation of calcium ion-dependent exocytosis,GO:0046676~negative regulation of insulin secretion,GO:0050768~negative regulation of neurogenesis,GO:0060379~cardiac muscle cell myoblast differentiation,GO:0070933~histone H4 deacetylation,GO:0071257~cellular response to electrical stimulus,GO:0071385~cellular response to glucocorticoid stimulus,GO:0071805~potassium ion transmembrane transport,GO:2000065~negative regulation of cortisol biosynthetic process,GO:2000706~negative regulation of dense core granule biogenesis,GO:2000740~negative regulation of mesenchymal stem cell differentiation,GO:2000798~negative regulation of amniotic stem cell differentiation, GO:0000785~chromatin,GO:0005634~nucleus,GO:0005829~cytosol,GO:0017053~transcriptional repressor complex,GO:0043234~protein complex, GO:0001046~core promoter sequence-specific DNA binding,GO:0001047~core promoter binding,GO:0001078~transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding,GO:0001228~transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding,GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003682~chromatin binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0005515~protein binding,GO:0008134~transcription factor binding,GO:0015271~outward rectifier potassium channel activity,GO:0032403~protein complex binding,GO:0044212~transcription regulatory region DNA binding,GO:0046872~metal ion binding, IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, rno04550:Signaling pathways regulating pluripotency of stem cells,rno05016:Huntington's disease, SM00355:ZnF_C2H2, Alternative splicing,Complete proteome,Metal-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Repressor,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:RE1-silencing transcription factor,compositionally biased region:Lys-rich,compositionally biased region:Poly-Ala,compositionally biased region:Pro-rich,region of interest:Interaction with RCOR1,region of interest:Interaction with SIN3A,region of interest:Interaction with SIN3B,splice variant,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, Q61493 REV3 like, DNA directed polymerase zeta catalytic subunit(Rev3l) Mus musculus GO:0006260~DNA replication,GO:0006281~DNA repair,GO:0006974~cellular response to DNA damage stimulus,GO:0019985~translesion synthesis,GO:0042276~error-prone translesion synthesis, GO:0005634~nucleus,GO:0005730~nucleolus,GO:0016035~zeta DNA polymerase complex, GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003887~DNA-directed DNA polymerase activity,GO:0008408~3'-5' exonuclease activity,GO:0016740~transferase activity,GO:0016779~nucleotidyltransferase activity,GO:0046872~metal ion binding,GO:0051536~iron-sulfur cluster binding,GO:0051539~4 iron, 4 sulfur cluster binding, IPR006133:DNA-directed DNA polymerase, family B, exonuclease domain,IPR006134:DNA-directed DNA polymerase, family B, multifunctional domain,IPR006172:DNA-directed DNA polymerase, family B,IPR012337:Ribonuclease H-like domain,IPR017964:DNA-directed DNA polymerase, family B, conserved site,IPR023211:DNA polymerase, palm domain,IPR025687:C4-type zinc-finger of DNA polymerase delta, mmu01100:Metabolic pathways,mmu03460:Fanconi anemia pathway, SM00486:POLBc, 3D-structure,4Fe-4S,Coiled coil,Complete proteome,DNA damage,DNA repair,DNA replication,DNA-binding,DNA-directed DNA polymerase,Iron,Iron-sulfur,Metal-binding,Nucleotidyltransferase,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Transferase,Zinc,Zinc-finger, chain:DNA polymerase zeta catalytic subunit,modified residue,sequence conflict,zinc finger region:C4-type, A2AAE1 RIKEN cDNA 4932438A13 gene(4932438A13Rik) Mus musculus GO:0001558~regulation of cell growth,GO:0006629~lipid metabolic process,GO:0007283~spermatogenesis,GO:0019915~lipid storage,GO:0045444~fat cell differentiation,GO:0051647~nucleus localization,GO:0060612~adipose tissue development, GO:0005634~nucleus,GO:0016020~membrane,GO:0016021~integral component of membrane, IPR018863:Fragile site-associated protein, C-terminal, SM01220:SM01220, Alternative splicing,Complete proteome,Membrane,Phosphoprotein,Proteomics identification,Reference proteome,Signal,Transmembrane,Transmembrane helix, chain:Uncharacterized protein KIAA1109,compositionally biased region:Poly-Lys,compositionally biased region:Poly-Pro,compositionally biased region:Poly-Ser,compositionally biased region:Ser-rich,modified residue,sequence conflict,splice variant,transmembrane region, F4JKK0 RING/U-box superfamily protein(CER9) Arabidopsis thaliana RNA processing and modification, GO:0008299~isoprenoid biosynthetic process,GO:0009414~response to water deprivation,GO:0010025~wax biosynthetic process,GO:0010143~cutin biosynthetic process,GO:0010345~suberin biosynthetic process,GO:0016567~protein ubiquitination,GO:0030433~ER-associated ubiquitin-dependent protein catabolic process,GO:0042335~cuticle development,GO:1900490~positive regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity, GO:0016021~integral component of membrane,GO:0030176~integral component of endoplasmic reticulum membrane, GO:0004842~ubiquitin-protein transferase activity,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:1904264~ubiquitin protein ligase activity involved in ERAD pathway, IPR011016:Zinc finger, RING-CH-type,IPR013083:Zinc finger, RING/FYVE/PHD-type, ath04141:Protein processing in endoplasmic reticulum, SM00744:RINGv, Alternative splicing,Coiled coil,Complete proteome,Ligase,Membrane,Metal-binding,Reference proteome,Transit peptide,Transmembrane,Transmembrane helix,Ubl conjugation pathway,Zinc,Zinc-finger, Q8CGC6 RNA binding motif protein 28(Rbm28) Mus musculus GO:0006397~mRNA processing,GO:0008380~RNA splicing, GO:0005634~nucleus,GO:0005681~spliceosomal complex,GO:0005730~nucleolus, GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0003723~RNA binding,GO:0044822~poly(A) RNA binding, IPR000504:RNA recognition motif domain,IPR012677:Nucleotide-binding, alpha-beta plait, mmu03008:Ribosome biogenesis in eukaryotes, SM00360:RRM, 3D-structure,Acetylation,Complete proteome,mRNA processing,mRNA splicing,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,RNA-binding,Spliceosome, chain:RNA-binding protein 28,compositionally biased region:Asp/Glu-rich (acidic),domain:RRM 1,domain:RRM 2,domain:RRM 3,domain:RRM 4,helix,modified residue,sequence conflict,strand,turn, Q96EV2 RNA binding motif protein 33(RBM33) Homo sapiens GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0044822~poly(A) RNA binding, IPR000504:RNA recognition motif domain,IPR012677:Nucleotide-binding, alpha-beta plait, SM00360:RRM, Acetylation,Alternative splicing,Coiled coil,Complete proteome,Methylation,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,RNA-binding, chain:RNA-binding protein 33,compositionally biased region:Glu-rich,compositionally biased region:His-rich,compositionally biased region:Pro-rich,domain:RRM,modified residue,sequence variant,splice variant, Q8VC34 RNA polymerase II associated protein 2(Rpap2) Mus musculus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0009301~snRNA transcription,GO:0070940~dephosphorylation of RNA polymerase II C-terminal domain, GO:0005634~nucleus,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0016591~DNA-directed RNA polymerase II, holoenzyme, GO:0004721~phosphoprotein phosphatase activity,GO:0004722~protein serine/threonine phosphatase activity,GO:0008420~CTD phosphatase activity,GO:0016787~hydrolase activity,GO:0046872~metal ion binding, IPR007308:Protein of unknown function DUF408, Acetylation,Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Hydrolase,Metal-binding,Nucleus,Phosphoprotein,Protein phosphatase,Proteomics identification,Reference proteome,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:RNA polymerase II-associated protein 2,sequence conflict,splice variant,transmembrane region, O22703 RNA-binding (RRM/RBD/RNP motifs) family protein with retrovirus zinc finger-like domain-containing protein(AtRZ-1b) Arabidopsis thaliana GO:0009409~response to cold,GO:0009414~response to water deprivation,GO:0009651~response to salt stress,GO:0045892~negative regulation of transcription, DNA-templated,GO:0048026~positive regulation of mRNA splicing, via spliceosome, GO:0005634~nucleus,GO:0016607~nuclear speck, GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003723~RNA binding,GO:0008270~zinc ion binding, IPR000504:RNA recognition motif domain,IPR001878:Zinc finger, CCHC-type,IPR012677:Nucleotide-binding, alpha-beta plait, ath03040:Spliceosome, SM00343:ZnF_C2HC,SM00360:RRM, Complete proteome,DNA-binding,Metal-binding,Nucleus,Phosphoprotein,Reference proteome,RNA-binding,Stress response,Zinc,Zinc-finger, Q1ZXD6 ROCO family protein kinase(roco5) Dictyostelium discoideum AX4 GO:0006468~protein phosphorylation,GO:0007264~small GTPase mediated signal transduction,GO:0016310~phosphorylation,GO:0030587~sorocarp development,GO:0035023~regulation of Rho protein signal transduction, GO:0005622~intracellular, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005085~guanyl-nucleotide exchange factor activity,GO:0005089~Rho guanyl-nucleotide exchange factor activity,GO:0005524~ATP binding,GO:0005525~GTP binding,GO:0016301~kinase activity,GO:0016740~transferase activity, IPR000219:Dbl homology (DH) domain,IPR000719:Protein kinase, catalytic domain,IPR001245:Serine-threonine/tyrosine-protein kinase catalytic domain,IPR001611:Leucine-rich repeat,IPR001849:Pleckstrin homology domain,IPR003591:Leucine-rich repeat, typical subtype,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR011993:Pleckstrin homology-like domain,IPR013684:Mitochondrial Rho-like,IPR017441:Protein kinase, ATP binding site,IPR020859:ROC GTPase,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00220:S_TKc,SM00233:PH,SM00369:LRR_TYP, ATP-binding,Complete proteome,GTP-binding,Guanine-nucleotide releasing factor,Kinase,Leucine-rich repeat,Nucleotide-binding,Reference proteome,Repeat,Serine/threonine-protein kinase,Transferase, Q6QI06 RPTOR independent companion of MTOR, complex 2(Rictor) Mus musculus GO:0001932~regulation of protein phosphorylation,GO:0001938~positive regulation of endothelial cell proliferation,GO:0007275~multicellular organism development,GO:0009790~embryo development,GO:0010468~regulation of gene expression,GO:0018105~peptidyl-serine phosphorylation,GO:0030838~positive regulation of actin filament polymerization,GO:0030950~establishment or maintenance of actin cytoskeleton polarity,GO:0031532~actin cytoskeleton reorganization,GO:0031929~TOR signaling,GO:0032008~positive regulation of TOR signaling,GO:0032956~regulation of actin cytoskeleton organization,GO:0033135~regulation of peptidyl-serine phosphorylation,GO:0042325~regulation of phosphorylation,GO:0043087~regulation of GTPase activity,GO:0050727~regulation of inflammatory response,GO:0050731~positive regulation of peptidyl-tyrosine phosphorylation,GO:0051896~regulation of protein kinase B signaling,GO:0051897~positive regulation of protein kinase B signaling,GO:2000114~regulation of establishment of cell polarity, GO:0031932~TORC2 complex, GO:0005515~protein binding,GO:0008047~enzyme activator activity,GO:0019901~protein kinase binding,GO:0043022~ribosome binding, IPR016024:Armadillo-type fold, mmu04150:mTOR signaling pathway, SM01307:SM01307,SM01308:SM01308,SM01309:SM01309,SM01310:SM01310, Alternative splicing,Complete proteome,Developmental protein,Phosphoprotein,Reference proteome, chain:Rapamycin-insensitive companion of mTOR,modified residue,sequence conflict,splice variant, Q06455 RUNX1 translocation partner 1(RUNX1T1) Homo sapiens GO:0006091~generation of precursor metabolites and energy,GO:0006351~transcription, DNA-templated,GO:0045599~negative regulation of fat cell differentiation,GO:0045892~negative regulation of transcription, DNA-templated, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0016363~nuclear matrix, GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0003714~transcription corepressor activity,GO:0005515~protein binding,GO:0046872~metal ion binding, IPR002893:Zinc finger, MYND-type,IPR003894:TAFH/NHR1,IPR013289:Eight-Twenty-One,IPR013290:Myeloid transforming gene on chromosome 8 (MTG8),IPR014896:NHR2-like, hsa05200:Pathways in cancer,hsa05202:Transcriptional misregulation in cancer,hsa05221:Acute myeloid leukemia, SM00549:TAFH, 3D-structure,Alternative splicing,Chromosomal rearrangement,Coiled coil,Complete proteome,DNA-binding,Metal-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Proto-oncogene,Reference proteome,Repressor,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Protein CBFA2T1,compositionally biased region:Poly-Pro,compositionally biased region:Poly-Ser,domain:TAFH,helix,modified residue,mutagenesis site,region of interest:Important for oligomerization,sequence conflict,sequence variant,site:Breakpoint for translocation to form AML1-MTG8 in AML-M2,splice variant,strand,zinc finger region:MYND-type, Q86X10 Ral GTPase activating protein non-catalytic beta subunit(RALGAPB) Homo sapiens GO:0051056~regulation of small GTPase mediated signal transduction,GO:0090630~activation of GTPase activity, GO:0005096~GTPase activator activity,GO:0046982~protein heterodimerization activity, IPR000331:Rap GTPase activating proteins domain, Alternative splicing,Complete proteome,GTPase activation,Phosphoprotein,Proteomics identification,Reference proteome, chain:Ral GTPase-activating protein beta subunit,domain:Rap-GAP,modified residue,sequence conflict,splice variant, O54916 RalBP1 associated Eps domain containing protein(Reps1) Mus musculus GO:0005886~plasma membrane,GO:0005905~clathrin-coated pit,GO:0016020~membrane, GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0017124~SH3 domain binding,GO:0046872~metal ion binding, IPR000261:EPS15 homology (EH),IPR002048:EF-hand domain,IPR011992:EF-hand-like domain,IPR018247:EF-Hand 1, calcium-binding site, SM00027:EH, 3D-structure,Alternative splicing,Calcium,Coated pit,Coiled coil,Complete proteome,Membrane,Metal-binding,Phosphoprotein,Proteomics identification,Reference proteome,Repeat, chain:RalBP1-associated Eps domain-containing protein 1,compositionally biased region:Pro-rich,domain:EF-hand,domain:EH 1,domain:EH 2,helix,modified residue,region of interest:Interaction with RALBP1,sequence conflict,splice variant,strand,turn, Q13905 Rap guanine nucleotide exchange factor 1(RAPGEF1) Homo sapiens h_integrinPathway:Integrin Signaling Pathway,h_metPathway:Signaling of Hepatocyte Growth Factor Receptor, GO:0000186~activation of MAPKK activity,GO:0001568~blood vessel development,GO:0007165~signal transduction,GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway,GO:0007264~small GTPase mediated signal transduction,GO:0010976~positive regulation of neuron projection development,GO:0016337~single organismal cell-cell adhesion,GO:0032486~Rap protein signal transduction,GO:0038180~nerve growth factor signaling pathway,GO:0043547~positive regulation of GTPase activity,GO:0046580~negative regulation of Ras protein signal transduction,GO:0048008~platelet-derived growth factor receptor signaling pathway,GO:0051898~negative regulation of protein kinase B signaling,GO:0061028~establishment of endothelial barrier,GO:0070373~negative regulation of ERK1 and ERK2 cascade,GO:0071320~cellular response to cAMP,GO:0090090~negative regulation of canonical Wnt signaling pathway,GO:1901888~regulation of cell junction assembly,GO:1990090~cellular response to nerve growth factor stimulus,GO:2000178~negative regulation of neural precursor cell proliferation, GO:0005622~intracellular,GO:0005768~endosome,GO:0005769~early endosome,GO:0005829~cytosol, GO:0005085~guanyl-nucleotide exchange factor activity,GO:0005515~protein binding,GO:0017034~Rap guanyl-nucleotide exchange factor activity,GO:0017124~SH3 domain binding, IPR000651:Ras-like guanine nucleotide exchange factor, N-terminal,IPR001895:Guanine-nucleotide dissociation stimulator CDC25,IPR019804:Ras guanine-nucleotide exchange factor, conserved site,IPR023578:Ras guanine nucleotide exchange factor, domain, hsa04015:Rap1 signaling pathway,hsa04510:Focal adhesion,hsa04722:Neurotrophin signaling pathway,hsa04910:Insulin signaling pathway,hsa05211:Renal cell carcinoma, SM00147:RasGEF,SM00229:RasGEFN, Alternative splicing,Complete proteome,Endosome,Guanine-nucleotide releasing factor,Isopeptide bond,Neurogenesis,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,SH3-binding,Ubl conjugation, chain:Rap guanine nucleotide exchange factor 1,compositionally biased region:Poly-Ser,domain:N-terminal Ras-GEF,domain:Ras-GEF,modified residue,sequence conflict,short sequence motif:SH3-binding,splice variant, Q75J93 Ras GTPase domain-containing protein(cpras1) Dictyostelium discoideum AX4 GO:0006886~intracellular protein transport,GO:0006888~ER to Golgi vesicle-mediated transport,GO:0007165~signal transduction,GO:0007264~small GTPase mediated signal transduction, GO:0016020~membrane,GO:0030127~COPII vesicle coat, GO:0000166~nucleotide binding,GO:0005525~GTP binding,GO:0008270~zinc ion binding, IPR001806:Small GTPase superfamily,IPR002035:von Willebrand factor, type A,IPR005225:Small GTP-binding protein domain,IPR006895:Zinc finger, Sec23/Sec24-type,IPR020849:Small GTPase superfamily, Ras type,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00327:VWA, Complete proteome,GTP-binding,Nucleotide-binding,Reference proteome, Q3B7D5 Ras association domain family member 2(Rassf2) Rattus norvegicus GO:0001501~skeletal system development,GO:0001503~ossification,GO:0006468~protein phosphorylation,GO:0007049~cell cycle,GO:0007165~signal transduction,GO:0031954~positive regulation of protein autophosphorylation,GO:0033137~negative regulation of peptidyl-serine phosphorylation,GO:0038168~epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade,GO:0042981~regulation of apoptotic process,GO:0043065~positive regulation of apoptotic process,GO:0045667~regulation of osteoblast differentiation,GO:0045670~regulation of osteoclast differentiation,GO:0045860~positive regulation of protein kinase activity,GO:0046330~positive regulation of JNK cascade,GO:0046849~bone remodeling,GO:0048872~homeostasis of number of cells,GO:0050821~protein stabilization,GO:1901222~regulation of NIK/NF-kappaB signaling,GO:1901223~negative regulation of NIK/NF-kappaB signaling, GO:0000776~kinetochore,GO:0000777~condensed chromosome kinetochore,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0043234~protein complex, GO:0004672~protein kinase activity, IPR000159:Ras-association,IPR011524:SARAH domain, SM00314:RA, Cell cycle,Centromere,Chromosome,Complete proteome,Cytoplasm,Kinetochore,Nucleus,Phosphoprotein,Reference proteome,Tumor suppressor, chain:Ras association domain-containing protein 2,domain:Ras-associating,domain:SARAH,modified residue, Q9FN03 Regulator of chromosome condensation (RCC1) family protein(UVR8) Arabidopsis thaliana Cell division and chromosome partitioning / Cytoskeleton, GO:0009408~response to heat,GO:0009411~response to UV,GO:0009649~entrainment of circadian clock,GO:0010224~response to UV-B,GO:0018298~protein-chromophore linkage, GO:0000785~chromatin,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0003682~chromatin binding,GO:0005085~guanyl-nucleotide exchange factor activity,GO:0005515~protein binding,GO:0009881~photoreceptor activity,GO:0042803~protein homodimerization activity,GO:0046872~metal ion binding, IPR000408:Regulator of chromosome condensation, RCC1,IPR009091:Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II, 3D-structure,Acetylation,Chromophore,Complete proteome,Cytoplasm,Nucleus,Photoreceptor protein,Receptor,Reference proteome,Repeat,Sensory transduction, Q80Y19 Rho GTPase activating protein 11A(Arhgap11a) Mus musculus GO:0007165~signal transduction, GO:0005096~GTPase activator activity, IPR000198:Rho GTPase-activating protein domain,IPR008936:Rho GTPase activation protein, SM00324:RhoGAP, Complete proteome,GTPase activation,Phosphoprotein,Proteomics identification,Reference proteome, chain:Rho GTPase-activating protein 11A,domain:Rho-GAP,modified residue, Q8N392 Rho GTPase activating protein 18(ARHGAP18) Homo sapiens GO:0007264~small GTPase mediated signal transduction,GO:0008360~regulation of cell shape,GO:0030833~regulation of actin filament polymerization,GO:0032956~regulation of actin cytoskeleton organization,GO:0043547~positive regulation of GTPase activity,GO:0051056~regulation of small GTPase mediated signal transduction,GO:0098609~cell-cell adhesion,GO:2000145~regulation of cell motility, GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005913~cell-cell adherens junction, GO:0005096~GTPase activator activity,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000198:Rho GTPase-activating protein domain,IPR008936:Rho GTPase activation protein, SM00324:RhoGAP, Alternative splicing,Complete proteome,Cytoplasm,GTPase activation,Phosphoprotein,Polymorphism,Reference proteome, chain:Rho GTPase-activating protein 18,domain:Rho-GAP,sequence conflict,sequence variant,splice variant, Q9C0H5 Rho GTPase activating protein 39(ARHGAP39) Homo sapiens RNA processing and modification, GO:0007165~signal transduction,GO:0043547~positive regulation of GTPase activity,GO:0051056~regulation of small GTPase mediated signal transduction, GO:0005634~nucleus,GO:0005829~cytosol,GO:0005856~cytoskeleton, GO:0005096~GTPase activator activity, IPR000198:Rho GTPase-activating protein domain,IPR000857:MyTH4 domain,IPR001202:WW domain,IPR008936:Rho GTPase activation protein, SM00139:MyTH4,SM00324:RhoGAP,SM00456:WW, Acetylation,Alternative splicing,Complete proteome,Nucleus,Phosphoprotein,Reference proteome,Repeat, chain:Uncharacterized protein KIAA1688,compositionally biased region:Pro-rich,domain:MyTH4,domain:Rho-GAP,domain:WW 1,domain:WW 2,modified residue, Q9ES28 Rho guanine nucleotide exchange factor (GEF7)(Arhgef7) Mus musculus GO:0002244~hematopoietic progenitor cell differentiation,GO:0007030~Golgi organization,GO:0007264~small GTPase mediated signal transduction,GO:0007399~nervous system development,GO:0010763~positive regulation of fibroblast migration,GO:0030032~lamellipodium assembly,GO:0032092~positive regulation of protein binding,GO:0035023~regulation of Rho protein signal transduction,GO:0035556~intracellular signal transduction,GO:0043065~positive regulation of apoptotic process,GO:0043547~positive regulation of GTPase activity,GO:0043615~astrocyte cell migration,GO:0048041~focal adhesion assembly,GO:0060124~positive regulation of growth hormone secretion,GO:1900026~positive regulation of substrate adhesion-dependent cell spreading,GO:1904424~regulation of GTP binding,GO:2000394~positive regulation of lamellipodium morphogenesis, GO:0000322~storage vacuole,GO:0001726~ruffle,GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005925~focal adhesion,GO:0005938~cell cortex,GO:0030027~lamellipodium,GO:0030054~cell junction,GO:0030426~growth cone,GO:0042995~cell projection,GO:0043005~neuron projection,GO:0043025~neuronal cell body,GO:0043234~protein complex, GO:0005085~guanyl-nucleotide exchange factor activity,GO:0005089~Rho guanyl-nucleotide exchange factor activity,GO:0005515~protein binding,GO:0019901~protein kinase binding, IPR000219:Dbl homology (DH) domain,IPR001331:Guanine-nucleotide dissociation stimulator, CDC24, conserved site,IPR001452:Src homology-3 domain,IPR001715:Calponin homology domain,IPR001849:Pleckstrin homology domain,IPR011511:Variant SH3,IPR011993:Pleckstrin homology-like domain, mmu04810:Regulation of actin cytoskeleton, SM00033:CH,SM00233:PH,SM00325:RhoGEF,SM00326:SH3, 3D-structure,Alternative initiation,Alternative splicing,Cell junction,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Guanine-nucleotide releasing factor,Neurogenesis,Phosphoprotein,Proteomics identification,Reference proteome,SH3 domain, chain:Rho guanine nucleotide exchange factor 7,domain:CH,domain:DH,domain:PH,domain:SH3,helix,modified residue,sequence conflict,splice variant,strand, Q96DR7 Rho guanine nucleotide exchange factor 26(ARHGEF26) Homo sapiens GO:0001886~endothelial cell morphogenesis,GO:0035023~regulation of Rho protein signal transduction,GO:0043547~positive regulation of GTPase activity,GO:0097178~ruffle assembly, GO:0001726~ruffle, GO:0005089~Rho guanyl-nucleotide exchange factor activity, IPR000219:Dbl homology (DH) domain,IPR001452:Src homology-3 domain,IPR001849:Pleckstrin homology domain,IPR011993:Pleckstrin homology-like domain, hsa05100:Bacterial invasion of epithelial cells, SM00233:PH,SM00325:RhoGEF,SM00326:SH3, Alternative promoter usage,Alternative splicing,Cell projection,Complete proteome,Guanine-nucleotide releasing factor,Phosphoprotein,Polymorphism,Reference proteome,SH3 domain, chain:SH3 domain-containing guanine exchange factor,compositionally biased region:Pro-rich,domain:DH,domain:PH,domain:SH3,modified residue,mutagenesis site,sequence conflict,sequence variant,splice variant, Q14155 Rho guanine nucleotide exchange factor 7(ARHGEF7) Homo sapiens Function unknown, GO:0002244~hematopoietic progenitor cell differentiation,GO:0007030~Golgi organization,GO:0007165~signal transduction,GO:0007399~nervous system development,GO:0010763~positive regulation of fibroblast migration,GO:0030032~lamellipodium assembly,GO:0032092~positive regulation of protein binding,GO:0035023~regulation of Rho protein signal transduction,GO:0035556~intracellular signal transduction,GO:0042059~negative regulation of epidermal growth factor receptor signaling pathway,GO:0043065~positive regulation of apoptotic process,GO:0043547~positive regulation of GTPase activity,GO:0048013~ephrin receptor signaling pathway,GO:0048041~focal adhesion assembly,GO:0051056~regulation of small GTPase mediated signal transduction,GO:0060124~positive regulation of growth hormone secretion,GO:1900026~positive regulation of substrate adhesion-dependent cell spreading,GO:1904424~regulation of GTP binding,GO:2000394~positive regulation of lamellipodium morphogenesis, GO:0000322~storage vacuole,GO:0001726~ruffle,GO:0005622~intracellular,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005925~focal adhesion,GO:0005938~cell cortex,GO:0030027~lamellipodium,GO:0043005~neuron projection,GO:0043025~neuronal cell body,GO:0043234~protein complex, GO:0005085~guanyl-nucleotide exchange factor activity,GO:0005089~Rho guanyl-nucleotide exchange factor activity,GO:0005515~protein binding,GO:0019901~protein kinase binding, IPR000219:Dbl homology (DH) domain,IPR001331:Guanine-nucleotide dissociation stimulator, CDC24, conserved site,IPR001452:Src homology-3 domain,IPR001715:Calponin homology domain,IPR001849:Pleckstrin homology domain,IPR011511:Variant SH3,IPR011993:Pleckstrin homology-like domain, hsa04810:Regulation of actin cytoskeleton, SM00033:CH,SM00233:PH,SM00325:RhoGEF,SM00326:SH3, 3D-structure,Acetylation,Alternative splicing,Cell junction,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Guanine-nucleotide releasing factor,Neurogenesis,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,SH3 domain, chain:Rho guanine nucleotide exchange factor 7,domain:CH,domain:DH,domain:PH,domain:SH3,helix,modified residue,sequence conflict,splice variant,strand,turn, O55043 Rho guanine nucleotide exchange factor 7(Arhgef7) Rattus norvegicus GO:0002244~hematopoietic progenitor cell differentiation,GO:0007030~Golgi organization,GO:0007264~small GTPase mediated signal transduction,GO:0010763~positive regulation of fibroblast migration,GO:0030032~lamellipodium assembly,GO:0032092~positive regulation of protein binding,GO:0035023~regulation of Rho protein signal transduction,GO:0035556~intracellular signal transduction,GO:0043065~positive regulation of apoptotic process,GO:0043547~positive regulation of GTPase activity,GO:0043615~astrocyte cell migration,GO:0048041~focal adhesion assembly,GO:0060124~positive regulation of growth hormone secretion,GO:1900026~positive regulation of substrate adhesion-dependent cell spreading,GO:1904424~regulation of GTP binding,GO:2000394~positive regulation of lamellipodium morphogenesis, GO:0000322~storage vacuole,GO:0001726~ruffle,GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005925~focal adhesion,GO:0005938~cell cortex,GO:0030027~lamellipodium,GO:0030426~growth cone,GO:0043005~neuron projection,GO:0043025~neuronal cell body,GO:0043234~protein complex, GO:0005085~guanyl-nucleotide exchange factor activity,GO:0005089~Rho guanyl-nucleotide exchange factor activity,GO:0005515~protein binding,GO:0019901~protein kinase binding, IPR000219:Dbl homology (DH) domain,IPR001331:Guanine-nucleotide dissociation stimulator, CDC24, conserved site,IPR001452:Src homology-3 domain,IPR001715:Calponin homology domain,IPR001849:Pleckstrin homology domain,IPR011511:Variant SH3,IPR011993:Pleckstrin homology-like domain, rno04810:Regulation of actin cytoskeleton, SM00033:CH,SM00233:PH,SM00325:RhoGEF,SM00326:SH3, 3D-structure,Cell junction,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Guanine-nucleotide releasing factor,Neurogenesis,Phosphoprotein,Proteomics identification,Reference proteome,SH3 domain, chain:Rho guanine nucleotide exchange factor 7,domain:DH,domain:PH,domain:SH3,helix,modified residue,strand, Q24498 Ryanodine receptor(RyR) Drosophila melanogaster GO:0006816~calcium ion transport,GO:0006874~cellular calcium ion homeostasis,GO:0006936~muscle contraction,GO:0007275~multicellular organism development,GO:0035206~regulation of hemocyte proliferation,GO:0060047~heart contraction,GO:0070588~calcium ion transmembrane transport,GO:0072347~response to anesthetic, GO:0005623~cell,GO:0005790~smooth endoplasmic reticulum,GO:0005875~microtubule associated complex,GO:0016021~integral component of membrane,GO:0030018~Z disc,GO:0033017~sarcoplasmic reticulum membrane,GO:0034704~calcium channel complex,GO:0042383~sarcolemma, GO:0005219~ryanodine-sensitive calcium-release channel activity,GO:0005509~calcium ion binding,GO:0048763~calcium-induced calcium release activity, IPR000699:Intracellular calcium-release channel,IPR001870:B30.2/SPRY domain,IPR003032:Ryanodine receptor Ryr,IPR003877:SPla/RYanodine receptor SPRY,IPR005821:Ion transport domain,IPR009460:Ryanodine Receptor TM 4-6,IPR011992:EF-hand-like domain,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR013333:Ryanodine receptor,IPR013662:RyR/IP3R Homology associated domain,IPR014821:Inositol 1,4,5-trisphosphate/ryanodine receptor,IPR015925:Ryanodine receptor-related,IPR016093:MIR motif, SM00449:SPRY,SM00472:MIR, Alternative splicing,Calcium,Calcium channel,Calcium transport,Complete proteome,Developmental protein,Ion channel,Ion transport,Ligand-gated ion channel,Membrane,Phosphoprotein,Proteomics identification,Receptor,Reference proteome,Repeat,Sarcoplasmic reticulum,Transmembrane,Transmembrane helix,Transport, chain:Ryanodine receptor 44F,compositionally biased region:Gly-rich,domain:B30.2/SPRY 1,domain:B30.2/SPRY 2,domain:B30.2/SPRY 3,domain:MIR 1,domain:MIR 2,domain:MIR 3,domain:MIR 4,domain:MIR 5,glycosylation site:N-linked (GlcNAc...),modified residue,region of interest:4 X approximate repeats,repeat:1,repeat:2,repeat:3,repeat:4,sequence conflict,splice variant,topological domain:Cytoplasmic,transmembrane region, Q9BY12 S-phase cyclin A associated protein in the ER(SCAPER) Homo sapiens GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005783~endoplasmic reticulum, GO:0003676~nucleic acid binding,GO:0008270~zinc ion binding, IPR003604:Zinc finger, U1-type, SM00451:ZnF_U1, Alternative splicing,Coiled coil,Complete proteome,Endoplasmic reticulum,Metal-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Zinc,Zinc-finger, chain:S phase cyclin A-associated protein in the endoplasmic reticulum,compositionally biased region:Glu-rich,modified residue,mutagenesis site,sequence conflict,sequence variant,splice variant,zinc finger region:C2H2-type, O76054 SEC14 like lipid binding 2(SEC14L2) Homo sapiens GO:0006351~transcription, DNA-templated,GO:0006810~transport,GO:0045540~regulation of cholesterol biosynthetic process,GO:0045893~positive regulation of transcription, DNA-templated, GO:0005622~intracellular,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0016021~integral component of membrane,GO:0070062~extracellular exosome, GO:0005215~transporter activity,GO:0005543~phospholipid binding,GO:0008431~vitamin E binding, IPR001071:Cellular retinaldehyde binding/alpha-tocopherol transport,IPR001251:CRAL-TRIO domain,IPR009038:GOLD,IPR011074:CRAL/TRIO, N-terminal domain, SM00516:SEC14,SM01100:SM01100, 3D-structure,Activator,Alternative splicing,Complete proteome,Cytoplasm,Lipid-binding,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Transcription,Transcription regulation,Transport, chain:SEC14-like protein 2,domain:CRAL-TRIO,domain:GOLD,helix,sequence conflict,sequence variant,strand,turn, O95487 SEC24 homolog B, COPII coat complex component(SEC24B) Homo sapiens Intracellular trafficking and secretion, GO:0001843~neural tube closure,GO:0002474~antigen processing and presentation of peptide antigen via MHC class I,GO:0003151~outflow tract morphogenesis,GO:0006886~intracellular protein transport,GO:0006888~ER to Golgi vesicle-mediated transport,GO:0016192~vesicle-mediated transport,GO:0019886~antigen processing and presentation of exogenous peptide antigen via MHC class II,GO:0021747~cochlear nucleus development,GO:0035909~aorta morphogenesis,GO:0048208~COPII vesicle coating,GO:0060088~auditory receptor cell stereocilium organization,GO:0060463~lung lobe morphogenesis,GO:0060982~coronary artery morphogenesis,GO:0061156~pulmonary artery morphogenesis,GO:0090178~regulation of establishment of planar polarity involved in neural tube closure,GO:1901301~regulation of cargo loading into COPII-coated vesicle, GO:0000139~Golgi membrane,GO:0005789~endoplasmic reticulum membrane,GO:0005829~cytosol,GO:0012507~ER to Golgi transport vesicle membrane,GO:0016020~membrane,GO:0030127~COPII vesicle coat,GO:0048471~perinuclear region of cytoplasm, GO:0005215~transporter activity,GO:0005515~protein binding,GO:0008270~zinc ion binding, IPR002035:von Willebrand factor, type A,IPR006895:Zinc finger, Sec23/Sec24-type,IPR006896:Sec23/Sec24, trunk domain,IPR006900:Sec23/Sec24, helical domain,IPR007123:Gelsolin domain,IPR012990:Sec23/Sec24 beta-sandwich, hsa04141:Protein processing in endoplasmic reticulum, 3D-structure,Acetylation,Alternative splicing,Complete proteome,Cytoplasm,Endoplasmic reticulum,ER-Golgi transport,Golgi apparatus,Membrane,Phosphoprotein,Polymorphism,Protein transport,Reference proteome,Transport, chain:Protein transport protein Sec24B,compositionally biased region:Poly-Glu,helix,modified residue,region of interest:Zinc finger-like,sequence conflict,sequence variant,splice variant,strand,turn, P53992 SEC24 homolog C, COPII coat complex component(SEC24C) Homo sapiens Intracellular trafficking and secretion, GO:0002474~antigen processing and presentation of peptide antigen via MHC class I,GO:0006886~intracellular protein transport,GO:0006888~ER to Golgi vesicle-mediated transport,GO:0019886~antigen processing and presentation of exogenous peptide antigen via MHC class II,GO:0048208~COPII vesicle coating, GO:0000139~Golgi membrane,GO:0005789~endoplasmic reticulum membrane,GO:0005829~cytosol,GO:0012507~ER to Golgi transport vesicle membrane,GO:0030127~COPII vesicle coat,GO:0048471~perinuclear region of cytoplasm, GO:0005515~protein binding,GO:0008270~zinc ion binding, IPR002035:von Willebrand factor, type A,IPR006895:Zinc finger, Sec23/Sec24-type,IPR006896:Sec23/Sec24, trunk domain,IPR006900:Sec23/Sec24, helical domain,IPR007123:Gelsolin domain,IPR012990:Sec23/Sec24 beta-sandwich, hsa04141:Protein processing in endoplasmic reticulum, 3D-structure,Alternative splicing,Complete proteome,Cytoplasm,Endoplasmic reticulum,ER-Golgi transport,Golgi apparatus,Membrane,Phosphoprotein,Polymorphism,Protein transport,Proteomics identification,Reference proteome,Transport, chain:Protein transport protein Sec24C,helix,modified residue,region of interest:Zinc finger-like,sequence variant,strand,turn, Q5F3X8 SEC31 homolog A (S. cerevisiae)(SEC31A) Gallus gallus GO:0015031~protein transport,GO:0016192~vesicle-mediated transport,GO:0051592~response to calcium ion, GO:0005789~endoplasmic reticulum membrane,GO:0012507~ER to Golgi transport vesicle membrane,GO:0030120~vesicle coat,GO:0030134~ER to Golgi transport vesicle,GO:0048471~perinuclear region of cytoplasm,GO:0070971~endoplasmic reticulum exit site, IPR001680:WD40 repeat,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain, gga04141:Protein processing in endoplasmic reticulum, SM00320:WD40, Coiled coil,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Endoplasmic reticulum,ER-Golgi transport,Membrane,Protein transport,Reference proteome,Repeat,Transport,WD repeat, chain:Protein transport protein Sec31A,compositionally biased region:Pro-rich,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7, Q8BTK5 SET and MYND domain containing 4(Smyd4) Mus musculus GO:0032259~methylation, GO:0008168~methyltransferase activity,GO:0016740~transferase activity,GO:0046872~metal ion binding, IPR001214:SET domain,IPR002893:Zinc finger, MYND-type,IPR011990:Tetratricopeptide-like helical, Alternative splicing,Complete proteome,Metal-binding,Methyltransferase,Polymorphism,Reference proteome,S-adenosyl-L-methionine,Transferase,Zinc,Zinc-finger, chain:SET and MYND domain-containing protein 4,domain:SET,sequence conflict,sequence variant,splice variant,zinc finger region:MYND-type, P58467 SET domain containing 4(Setd4) Mus musculus GO:0018023~peptidyl-lysine trimethylation,GO:0018026~peptidyl-lysine monomethylation,GO:0032259~methylation,GO:0042254~ribosome biogenesis, GO:0005730~nucleolus, GO:0008168~methyltransferase activity,GO:0016279~protein-lysine N-methyltransferase activity,GO:0016740~transferase activity, IPR001214:SET domain,IPR015353:Rubisco LS methyltransferase, substrate-binding domain,IPR016852:Lysine methylase, YDR198C, predicted, PIRSF027158:lysine methylase, YDR198C type, Complete proteome,Methyltransferase,Reference proteome,S-adenosyl-L-methionine,Transferase, chain:SET domain-containing protein 4,compositionally biased region:Poly-Arg,domain:SET, Q01105 SET nuclear proto-oncogene(SET) Homo sapiens h_setPathway:Granzyme A mediated Apoptosis Pathway, GO:0006260~DNA replication,GO:0006334~nucleosome assembly,GO:0006337~nucleosome disassembly,GO:0006913~nucleocytoplasmic transport,GO:0016032~viral process,GO:0035067~negative regulation of histone acetylation,GO:0043086~negative regulation of catalytic activity,GO:0043488~regulation of mRNA stability,GO:0043524~negative regulation of neuron apoptotic process,GO:0045892~negative regulation of transcription, DNA-templated, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005783~endoplasmic reticulum,GO:0005829~cytosol,GO:0043234~protein complex,GO:0048471~perinuclear region of cytoplasm, GO:0003677~DNA binding,GO:0004864~protein phosphatase inhibitor activity,GO:0005515~protein binding,GO:0008601~protein phosphatase type 2A regulator activity,GO:0019888~protein phosphatase regulator activity,GO:0042393~histone binding, IPR002164:Nucleosome assembly protein (NAP), 3D-structure,Acetylation,Alternative splicing,Chaperone,Chromosomal rearrangement,Coiled coil,Complete proteome,Cytoplasm,Direct protein sequencing,DNA-binding,Endoplasmic reticulum,Host-virus interaction,Isopeptide bond,Methylation,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Proto-oncogene,Reference proteome,Ubl conjugation, chain:Protein SET,compositionally biased region:Asp/Glu-rich (highly acidic),cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),helix,modified residue,site:Breakpoint for translocation to form SET- CAN oncogene,splice variant,strand,turn, Q6ZV89 SH2 domain containing 5(SH2D5) Homo sapiens GO:0014069~postsynaptic density,GO:0030054~cell junction,GO:0045211~postsynaptic membrane, IPR000980:SH2 domain,IPR006020:Phosphotyrosine interaction domain,IPR011993:Pleckstrin homology-like domain, SM00462:PTB, Alternative splicing,Cell junction,Cell membrane,Complete proteome,Membrane,Postsynaptic cell membrane,Proteomics identification,Reference proteome,SH2 domain,Synapse, chain:SH2 domain-containing protein 5,domain:SH2,modified residue, Q1HE26 SMAD family member 4(SMAD4) Bos taurus GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0001541~ovarian follicle development,GO:0001658~branching involved in ureteric bud morphogenesis,GO:0001666~response to hypoxia,GO:0001701~in utero embryonic development,GO:0001702~gastrulation with mouth forming second,GO:0003190~atrioventricular valve formation,GO:0003198~epithelial to mesenchymal transition involved in endocardial cushion formation,GO:0003251~positive regulation of cell proliferation involved in heart valve morphogenesis,GO:0003279~cardiac septum development,GO:0003360~brainstem development,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006879~cellular iron ion homeostasis,GO:0007179~transforming growth factor beta receptor signaling pathway,GO:0007183~SMAD protein complex assembly,GO:0007283~spermatogenesis,GO:0007338~single fertilization,GO:0007411~axon guidance,GO:0007492~endoderm development,GO:0007498~mesoderm development,GO:0008283~cell proliferation,GO:0008285~negative regulation of cell proliferation,GO:0010718~positive regulation of epithelial to mesenchymal transition,GO:0010862~positive regulation of pathway-restricted SMAD protein phosphorylation,GO:0014033~neural crest cell differentiation,GO:0030308~negative regulation of cell growth,GO:0030509~BMP signaling pathway,GO:0030511~positive regulation of transforming growth factor beta receptor signaling pathway,GO:0030513~positive regulation of BMP signaling pathway,GO:0032525~somite rostral/caudal axis specification,GO:0032909~regulation of transforming growth factor beta2 production,GO:0033686~positive regulation of luteinizing hormone secretion,GO:0035556~intracellular signal transduction,GO:0036302~atrioventricular canal development,GO:0042118~endothelial cell activation,GO:0042733~embryonic digit morphogenesis,GO:0046881~positive regulation of follicle-stimulating hormone secretion,GO:0048589~developmental growth,GO:0048663~neuron fate commitment,GO:0048733~sebaceous gland development,GO:0048859~formation of anatomical boundary,GO:0051098~regulation of binding,GO:0051571~positive regulation of histone H3-K4 methylation,GO:0051797~regulation of hair follicle development,GO:0060021~palate development,GO:0060065~uterus development,GO:0060391~positive regulation of SMAD protein import into nucleus,GO:0060395~SMAD protein signal transduction,GO:0060548~negative regulation of cell death,GO:0060956~endocardial cell differentiation,GO:0061040~female gonad morphogenesis,GO:0070102~interleukin-6-mediated signaling pathway,GO:0072133~metanephric mesenchyme morphogenesis,GO:0072134~nephrogenic mesenchyme morphogenesis,GO:0072520~seminiferous tubule development,GO:2000617~positive regulation of histone H3-K9 acetylation, GO:0000790~nuclear chromatin,GO:0005634~nucleus,GO:0005667~transcription factor complex,GO:0005737~cytoplasm,GO:0032444~activin responsive factor complex,GO:0071141~SMAD protein complex, GO:0000978~RNA polymerase II core promoter proximal region sequence-specific DNA binding,GO:0001076~transcription factor activity, RNA polymerase II transcription factor binding,GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding,GO:0003677~DNA binding,GO:0003682~chromatin binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0030616~transforming growth factor beta receptor, common-partner cytoplasmic mediator activity,GO:0046872~metal ion binding, IPR001132:SMAD domain, Dwarfin-type,IPR003619:MAD homology 1, Dwarfin-type,IPR008984:SMAD/FHA domain,IPR013019:MAD homology, MH1,IPR013790:Dwarfin,IPR017855:SMAD domain-like, bta04068:FoxO signaling pathway,bta04110:Cell cycle,bta04310:Wnt signaling pathway,bta04350:TGF-beta signaling pathway,bta04390:Hippo signaling pathway,bta04520:Adherens junction,bta04550:Signaling pathways regulating pluripotency of stem cells,bta05161:Hepatitis B,bta05166:HTLV-I infection,bta05200:Pathways in cancer,bta05210:Colorectal cancer,bta05212:Pancreatic cancer,bta05220:Chronic myeloid leukemia, SM00523:DWA,SM00524:DWB, Acetylation,Coiled coil,Complete proteome,Cytoplasm,DNA-binding,Isopeptide bond,Metal-binding,Nucleus,Reference proteome,Transcription,Transcription regulation,Ubl conjugation,Zinc, chain:Mothers against decapentaplegic homolog 4,compositionally biased region:Ala-rich,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),domain:MH1,domain:MH2,modified residue,region of interest:SAD, Q13485 SMAD family member 4(SMAD4) Homo sapiens h_alkPathway:ALK in cardiac myocytes,h_ctcfPathway:CTCF: First Multivalent Nuclear Factor,h_g1Pathway:Cell Cycle: G1/S Check Point ,h_nthiPathway:NFkB activation by Nontypeable Hemophilus influenzae,h_tgfbPathway:TGF beta signaling pathway,h_tob1Pathway:Role of Tob in T-cell activation,h_wntPathway:WNT Signaling Pathway, GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0001541~ovarian follicle development,GO:0001658~branching involved in ureteric bud morphogenesis,GO:0001666~response to hypoxia,GO:0001701~in utero embryonic development,GO:0001702~gastrulation with mouth forming second,GO:0003148~outflow tract septum morphogenesis,GO:0003190~atrioventricular valve formation,GO:0003198~epithelial to mesenchymal transition involved in endocardial cushion formation,GO:0003220~left ventricular cardiac muscle tissue morphogenesis,GO:0003251~positive regulation of cell proliferation involved in heart valve morphogenesis,GO:0003279~cardiac septum development,GO:0003360~brainstem development,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006366~transcription from RNA polymerase II promoter,GO:0006879~cellular iron ion homeostasis,GO:0007179~transforming growth factor beta receptor signaling pathway,GO:0007183~SMAD protein complex assembly,GO:0007283~spermatogenesis,GO:0007338~single fertilization,GO:0007411~axon guidance,GO:0007492~endoderm development,GO:0007498~mesoderm development,GO:0008283~cell proliferation,GO:0008285~negative regulation of cell proliferation,GO:0010614~negative regulation of cardiac muscle hypertrophy,GO:0010718~positive regulation of epithelial to mesenchymal transition,GO:0010862~positive regulation of pathway-restricted SMAD protein phosphorylation,GO:0014033~neural crest cell differentiation,GO:0017015~regulation of transforming growth factor beta receptor signaling pathway,GO:0030308~negative regulation of cell growth,GO:0030509~BMP signaling pathway,GO:0030511~positive regulation of transforming growth factor beta receptor signaling pathway,GO:0030513~positive regulation of BMP signaling pathway,GO:0032525~somite rostral/caudal axis specification,GO:0032909~regulation of transforming growth factor beta2 production,GO:0033686~positive regulation of luteinizing hormone secretion,GO:0035019~somatic stem cell population maintenance,GO:0035556~intracellular signal transduction,GO:0036302~atrioventricular canal development,GO:0042118~endothelial cell activation,GO:0042733~embryonic digit morphogenesis,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0046881~positive regulation of follicle-stimulating hormone secretion,GO:0048589~developmental growth,GO:0048663~neuron fate commitment,GO:0048733~sebaceous gland development,GO:0048859~formation of anatomical boundary,GO:0051098~regulation of binding,GO:0051571~positive regulation of histone H3-K4 methylation,GO:0051797~regulation of hair follicle development,GO:0060021~palate development,GO:0060065~uterus development,GO:0060391~positive regulation of SMAD protein import into nucleus,GO:0060395~SMAD protein signal transduction,GO:0060412~ventricular septum morphogenesis,GO:0060548~negative regulation of cell death,GO:0060956~endocardial cell differentiation,GO:0061040~female gonad morphogenesis,GO:0070102~interleukin-6-mediated signaling pathway,GO:0070373~negative regulation of ERK1 and ERK2 cascade,GO:0071559~response to transforming growth factor beta,GO:0071773~cellular response to BMP stimulus,GO:0072133~metanephric mesenchyme morphogenesis,GO:0072134~nephrogenic mesenchyme morphogenesis,GO:0072520~seminiferous tubule development,GO:1901522~positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus,GO:2000617~positive regulation of histone H3-K9 acetylation, GO:0000790~nuclear chromatin,GO:0005622~intracellular,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005667~transcription factor complex,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0032444~activin responsive factor complex,GO:0071141~SMAD protein complex,GO:0090575~RNA polymerase II transcription factor complex, GO:0000977~RNA polymerase II regulatory region sequence-specific DNA binding,GO:0000978~RNA polymerase II core promoter proximal region sequence-specific DNA binding,GO:0000987~core promoter proximal region sequence-specific DNA binding,GO:0000988~transcription factor activity, protein binding,GO:0001076~transcription factor activity, RNA polymerase II transcription factor binding,GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding,GO:0001085~RNA polymerase II transcription factor binding,GO:0001228~transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding,GO:0003677~DNA binding,GO:0003682~chromatin binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0005515~protein binding,GO:0005518~collagen binding,GO:0030616~transforming growth factor beta receptor, common-partner cytoplasmic mediator activity,GO:0042802~identical protein binding,GO:0042803~protein homodimerization activity,GO:0043565~sequence-specific DNA binding,GO:0044212~transcription regulatory region DNA binding,GO:0046872~metal ion binding,GO:0046982~protein heterodimerization activity,GO:0070411~I-SMAD binding,GO:0070412~R-SMAD binding, IPR001132:SMAD domain, Dwarfin-type,IPR003619:MAD homology 1, Dwarfin-type,IPR008984:SMAD/FHA domain,IPR013019:MAD homology, MH1,IPR013790:Dwarfin,IPR017855:SMAD domain-like, hsa04068:FoxO signaling pathway,hsa04110:Cell cycle,hsa04310:Wnt signaling pathway,hsa04350:TGF-beta signaling pathway,hsa04390:Hippo signaling pathway,hsa04520:Adherens junction,hsa04550:Signaling pathways regulating pluripotency of stem cells,hsa05161:Hepatitis B,hsa05166:HTLV-I infection,hsa05200:Pathways in cancer,hsa05210:Colorectal cancer,hsa05212:Pancreatic cancer,hsa05220:Chronic myeloid leukemia, 139210~Myhre syndrome,174900~Polyposis, juvenile intestinal,175050~Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome,260350~Pancreatic cancer, somatic, SM00523:DWA,SM00524:DWB, 3D-structure,Acetylation,Coiled coil,Complete proteome,Cytoplasm,Disease mutation,DNA-binding,Isopeptide bond,Metal-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transcription,Transcription regulation,Ubl conjugation,Zinc, chain:Mothers against decapentaplegic homolog 4,compositionally biased region:Poly-Ala,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),domain:MH1,domain:MH2,helix,modified residue,mutagenesis site,region of interest:SAD,sequence variant,strand,turn, Q6P5D8 SMC hinge domain containing 1(Smchd1) Mus musculus GO:0009048~dosage compensation by inactivation of X chromosome,GO:0051276~chromosome organization,GO:0060821~inactivation of X chromosome by DNA methylation, GO:0000784~nuclear chromosome, telomeric region,GO:0001740~Barr body,GO:0005694~chromosome, GO:0005524~ATP binding, IPR003594:Histidine kinase-like ATPase, ATP-binding domain,IPR010935:SMCs flexible hinge, SM00968:SM00968, Acetylation,Chromosome,Complete proteome,Isopeptide bond,Phosphoprotein,Reference proteome,Ubl conjugation, chain:Structural maintenance of chromosomes flexible hinge domain-containing protein 1,modified residue,sequence conflict, Q9BQI6 SMC5-SMC6 complex localization factor 1(SLF1) Homo sapiens GO:0006270~DNA replication initiation,GO:0006281~DNA repair,GO:0006974~cellular response to DNA damage stimulus,GO:0007095~mitotic G2 DNA damage checkpoint,GO:0031334~positive regulation of protein complex assembly,GO:0033314~mitotic DNA replication checkpoint,GO:0034184~positive regulation of maintenance of mitotic sister chromatid cohesion,GO:1990166~protein localization to site of double-strand break,GO:2000781~positive regulation of double-strand break repair, GO:0000786~nucleosome,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0035861~site of double-strand break,GO:0042405~nuclear inclusion body, GO:0005515~protein binding,GO:0031625~ubiquitin protein ligase binding,GO:0032403~protein complex binding, IPR001357:BRCT domain,IPR002110:Ankyrin repeat,IPR020683:Ankyrin repeat-containing domain, SM00248:ANK,SM00292:BRCT, Alternative splicing,ANK repeat,Complete proteome,Cytoplasm,Cytoskeleton,DNA damage,DNA repair,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Repeat, chain:Ankyrin repeat domain-containing protein 32,domain:BRCT 1,domain:BRCT 2,modified residue,repeat:ANK 1,repeat:ANK 2,repeat:ANK 3,sequence conflict,sequence variant, Q8BKX6 SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)(Smg1) Mus musculus GO:0000184~nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,GO:0000723~telomere maintenance,GO:0006281~DNA repair,GO:0006950~response to stress,GO:0006974~cellular response to DNA damage stimulus,GO:0016310~phosphorylation,GO:0018105~peptidyl-serine phosphorylation,GO:0046777~protein autophosphorylation,GO:0046854~phosphatidylinositol phosphorylation, GO:0005634~nucleus,GO:0005737~cytoplasm, GO:0000166~nucleotide binding,GO:0004674~protein serine/threonine kinase activity,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0016740~transferase activity,GO:0042162~telomeric DNA binding,GO:0044822~poly(A) RNA binding,GO:0046872~metal ion binding, IPR000403:Phosphatidylinositol 3-/4-kinase, catalytic domain,IPR003152:PIK-related kinase, FATC,IPR011009:Protein kinase-like domain,IPR014009:PIK-related kinase,IPR016024:Armadillo-type fold,IPR018936:Phosphatidylinositol 3/4-kinase, conserved site, mmu03015:mRNA surveillance pathway, SM00146:PI3Kc,SM01343:SM01343, Acetylation,Alternative splicing,ATP-binding,Complete proteome,Cytoplasm,Direct protein sequencing,DNA damage,DNA repair,Kinase,Manganese,Metal-binding,Nonsense-mediated mRNA decay,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Serine/threonine-protein kinase,Transferase, chain:Serine/threonine-protein kinase Smg1,domain:FAT,domain:FATC,domain:PI3K/PI4K,modified residue,repeat:HEAT,sequence conflict,splice variant, Q96Q15 SMG1, nonsense mediated mRNA decay associated PI3K related kinase(SMG1) Homo sapiens GO:0000184~nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,GO:0000723~telomere maintenance,GO:0006281~DNA repair,GO:0006406~mRNA export from nucleus,GO:0006950~response to stress,GO:0018105~peptidyl-serine phosphorylation,GO:0046777~protein autophosphorylation,GO:0046854~phosphatidylinositol phosphorylation, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0042162~telomeric DNA binding,GO:0044822~poly(A) RNA binding,GO:0046872~metal ion binding, IPR000403:Phosphatidylinositol 3-/4-kinase, catalytic domain,IPR003152:PIK-related kinase, FATC,IPR011009:Protein kinase-like domain,IPR011989:Armadillo-like helical,IPR014009:PIK-related kinase,IPR016024:Armadillo-type fold,IPR018936:Phosphatidylinositol 3/4-kinase, conserved site, hsa03015:mRNA surveillance pathway, SM00146:PI3Kc,SM01343:SM01343, Acetylation,Alternative splicing,ATP-binding,Coiled coil,Complete proteome,Cytoplasm,DNA damage,DNA repair,Kinase,Manganese,Metal-binding,Nonsense-mediated mRNA decay,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Serine/threonine-protein kinase,Transferase, chain:Serine/threonine-protein kinase Smg1,domain:FAT,domain:FATC,domain:PI3K/PI4K,modified residue,mutagenesis site,repeat:HEAT,sequence conflict,sequence variant,splice variant, Q38997 SNF1 kinase homolog 10(KIN10) Arabidopsis thaliana GO:0003006~developmental process involved in reproduction,GO:0005975~carbohydrate metabolic process,GO:0006468~protein phosphorylation,GO:0006633~fatty acid biosynthetic process,GO:0009594~detection of nutrient,GO:0009738~abscisic acid-activated signaling pathway,GO:0010050~vegetative phase change,GO:0010150~leaf senescence,GO:0010182~sugar mediated signaling pathway,GO:0035556~intracellular signal transduction,GO:0042128~nitrate assimilation,GO:0080022~primary root development, GO:0000152~nuclear ubiquitin ligase complex,GO:0005634~nucleus,GO:0005737~cytoplasm, GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding, IPR000719:Protein kinase, catalytic domain,IPR001772:Kinase associated domain 1 (KA1),IPR008271:Serine/threonine-protein kinase, active site,IPR009060:UBA-like,IPR011009:Protein kinase-like domain,IPR015940:Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote,IPR017441:Protein kinase, ATP binding site, ath04140:Regulation of autophagy,ath04931:Insulin resistance, SM00165:UBA,SM00220:S_TKc, Alternative splicing,ATP-binding,Carbohydrate metabolism,Complete proteome,Fatty acid biosynthesis,Fatty acid metabolism,Isopeptide bond,Kinase,Lipid biosynthesis,Lipid metabolism,Nitrate assimilation,Nucleotide-binding,Phosphoprotein,Reference proteome,Serine/threonine-protein kinase,Transferase,Ubl conjugation,Ubl conjugation pathway, active site:Proton acceptor,binding site:ATP,chain:SNF1-related protein kinase catalytic subunit alpha KIN10,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),domain:KA1,domain:Protein kinase,domain:UBA,nucleotide phosphate-binding region:ATP,splice variant, Q149N8 SNF2 histone linker PHD RING helicase(SHPRH) Homo sapiens GO:0000209~protein polyubiquitination,GO:0006281~DNA repair,GO:0006334~nucleosome assembly,GO:0006974~cellular response to DNA damage stimulus, GO:0000786~nucleosome,GO:0005634~nucleus, GO:0003677~DNA binding,GO:0004386~helicase activity,GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0031625~ubiquitin protein ligase binding, IPR000330:SNF2-related,IPR001650:Helicase, C-terminal,IPR001841:Zinc finger, RING-type,IPR001965:Zinc finger, PHD-type,IPR005818:Histone H1/H5,IPR011011:Zinc finger, FYVE/PHD-type,IPR011991:Winged helix-turn-helix DNA-binding domain,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR017907:Zinc finger, RING-type, conserved site,IPR018957:Zinc finger, C3HC4 RING-type,IPR019786:Zinc finger, PHD-type, conserved site,IPR019787:Zinc finger, PHD-finger,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00184:RING,SM00249:PHD,SM00487:DEXDc,SM00490:HELICc,SM00526:H15, 3D-structure,Alternative splicing,ATP-binding,Complete proteome,DNA damage,DNA repair,Helicase,Hydrolase,Ligase,Metal-binding,Nucleotide-binding,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Ubl conjugation pathway,Zinc,Zinc-finger, chain:E3 ubiquitin-protein ligase SHPRH,domain:Helicase ATP-binding; first part,domain:Helicase ATP-binding; second part,domain:Helicase C-terminal,domain:Histone H1,mutagenesis site,nucleotide phosphate-binding region:ATP,sequence conflict,sequence variant,short sequence motif:DEAQ box,splice variant,zinc finger region:PHD-type,zinc finger region:RING-type, Q5U3V9 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)(snf8) Danio rerio GO:0006810~transport,GO:0015031~protein transport,GO:0043328~protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, GO:0000814~ESCRT II complex,GO:0005737~cytoplasm, IPR007286:EAP30,IPR011991:Winged helix-turn-helix DNA-binding domain,IPR016689:ESCRT-2 complex, Snf8, dre04144:Endocytosis, PIRSF017215:ESCRT-2 complex, Vps22 subunit, Coiled coil,Complete proteome,Cytoplasm,Protein transport,Reference proteome,Transport, chain:Vacuolar-sorting protein SNF8,sequence conflict, Q7KZ85 SPT6 homolog, histone chaperone(SUPT6H) Homo sapiens Transcription, GO:0006338~chromatin remodeling,GO:0006342~chromatin silencing,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006397~mRNA processing,GO:0008380~RNA splicing,GO:0010793~regulation of mRNA export from nucleus,GO:0016032~viral process,GO:0032968~positive regulation of transcription elongation from RNA polymerase II promoter,GO:0034728~nucleosome organization,GO:0042789~mRNA transcription from RNA polymerase II promoter,GO:0045191~regulation of isotype switching,GO:0050684~regulation of mRNA processing,GO:0051028~mRNA transport,GO:0051147~regulation of muscle cell differentiation,GO:0061086~negative regulation of histone H3-K27 methylation,GO:0070827~chromatin maintenance, GO:0005634~nucleus,GO:0008023~transcription elongation factor complex,GO:0035327~transcriptionally active chromatin, GO:0000991~transcription factor activity, core RNA polymerase II binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0005515~protein binding,GO:0031491~nucleosome binding,GO:0042393~histone binding,GO:0044822~poly(A) RNA binding, IPR000980:SH2 domain,IPR003029:Ribosomal protein S1, RNA-binding domain,IPR006641:YqgF/RNase H-like domain,IPR010994:RuvA domain 2-like,IPR012337:Ribonuclease H-like domain,IPR012340:Nucleic acid-binding, OB-fold,IPR017072:Transcription elongation factor Spt6,IPR022967:RNA-binding domain, S1,IPR023097:Tex RuvX-like domain,IPR023323:Tex-like domain, PIRSF036947:transcription elongation factor Spt6, SM00252:SH2,SM00316:SM00316,SM00732:YqgFc, Acetylation,Alternative splicing,Chaperone,Coiled coil,Complete proteome,Host-virus interaction,mRNA processing,mRNA splicing,mRNA transport,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Transcription,Transcription regulation,Transport, chain:Transcription elongation factor SPT6,compositionally biased region:Asp/Glu-rich,compositionally biased region:Poly-Ser,domain:S1 motif,domain:SH2,modified residue,sequence conflict,splice variant, A0JPH4 SREBF chaperone S homeolog(scap.S) Xenopus laevis GO:0008203~cholesterol metabolic process,GO:0032933~SREBP signaling pathway, GO:0000139~Golgi membrane,GO:0005789~endoplasmic reticulum membrane,GO:0012507~ER to Golgi transport vesicle membrane,GO:0016021~integral component of membrane, GO:0015485~cholesterol binding, IPR000731:Sterol-sensing domain,IPR001680:WD40 repeat,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site, SM00320:WD40, Cholesterol metabolism,Cytoplasmic vesicle,Endoplasmic reticulum,Glycoprotein,Golgi apparatus,Lipid metabolism,Membrane,Repeat,Steroid metabolism,Sterol metabolism,Transmembrane,Transmembrane helix,WD repeat, chain:Sterol regulatory element-binding protein cleavage-activating protein,domain:SSD,glycosylation site:N-linked (GlcNAc...),region of interest:ER export signal,region of interest:Interaction with srebf,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, Q7RTN6 STE20-related kinase adaptor alpha(STRADA) Homo sapiens GO:0006468~protein phosphorylation,GO:0006611~protein export from nucleus,GO:0007050~cell cycle arrest,GO:0032147~activation of protein kinase activity,GO:0071902~positive regulation of protein serine/threonine kinase activity, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0004672~protein kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0019900~kinase binding,GO:0030295~protein kinase activator activity,GO:0043539~protein serine/threonine kinase activator activity, IPR000719:Protein kinase, catalytic domain,IPR011009:Protein kinase-like domain, hsa04150:mTOR signaling pathway,hsa04152:AMPK signaling pathway, 611087~Polyhydramnios, megalencephaly, and symptomatic epilepsy, SM00220:S_TKc, 3D-structure,Alternative splicing,ATP-binding,Cell cycle,Chromosomal rearrangement,Complete proteome,Cytoplasm,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:STE20-related kinase adapter protein alpha,domain:Protein kinase,modified residue,mutagenesis site,sequence conflict,sequence variant,splice variant, Q3UUJ4 STE20-related kinase adaptor alpha(Strada) Mus musculus GO:0006468~protein phosphorylation,GO:0006611~protein export from nucleus,GO:0007049~cell cycle,GO:0032147~activation of protein kinase activity,GO:0051291~protein heterooligomerization, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0016021~integral component of membrane,GO:0043234~protein complex, GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0019900~kinase binding,GO:0030295~protein kinase activator activity,GO:0043539~protein serine/threonine kinase activator activity, IPR000719:Protein kinase, catalytic domain,IPR001245:Serine-threonine/tyrosine-protein kinase catalytic domain,IPR011009:Protein kinase-like domain, mmu04150:mTOR signaling pathway,mmu04152:AMPK signaling pathway, Alternative splicing,Cell cycle,Complete proteome,Cytoplasm,Membrane,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix, chain:STE20-related kinase adapter protein alpha,domain:Protein kinase,modified residue,splice variant, Q5FVJ8 SUMO/sentrin peptidase family member, NEDD8 specific(Senp8) Rattus norvegicus GO:0006508~proteolysis, GO:0008234~cysteine-type peptidase activity, IPR003653:Peptidase C48, SUMO/Sentrin/Ubl1, Acetylation,Complete proteome,Hydrolase,Protease,Reference proteome,Thiol protease,Ubl conjugation pathway, active site:Nucleophile,chain:Sentrin-specific protease 8,modified residue,region of interest:Protease, Q6P7W0 SUMO/sentrin specific peptidase 6(Senp6) Mus musculus GO:0006508~proteolysis,GO:0016925~protein sumoylation,GO:0016926~protein desumoylation,GO:0070646~protein modification by small protein removal,GO:0090169~regulation of spindle assembly,GO:0090234~regulation of kinetochore assembly, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm, GO:0008233~peptidase activity,GO:0008234~cysteine-type peptidase activity,GO:0016787~hydrolase activity,GO:0016929~SUMO-specific protease activity, IPR003653:Peptidase C48, SUMO/Sentrin/Ubl1, Alternative splicing,Complete proteome,Hydrolase,Nucleus,Phosphoprotein,Protease,Proteomics identification,Reference proteome,Thiol protease,Ubl conjugation pathway, chain:Sentrin-specific protease 6,modified residue,region of interest:Protease,sequence conflict,splice variant, Q28DS0 SUMO1 activating enzyme subunit 1(sae1) Xenopus tropicalis GO:0007346~regulation of mitotic cell cycle,GO:0016925~protein sumoylation,GO:0060216~definitive hemopoiesis,GO:0061484~hematopoietic stem cell homeostasis, GO:0005634~nucleus,GO:0005829~cytosol, GO:0008022~protein C-terminus binding,GO:0008641~small protein activating enzyme activity,GO:0019948~SUMO activating enzyme activity, IPR000011:Ubiquitin/SUMO-activating enzyme E1,IPR000594:UBA/THIF-type NAD/FAD binding fold,IPR016040:NAD(P)-binding domain, xtr04120:Ubiquitin mediated proteolysis, Complete proteome,Ligase,Nucleus,Reference proteome,Ubl conjugation pathway, chain:SUMO-activating enzyme subunit 1, Q9P0U3 SUMO1/sentrin specific peptidase 1(SENP1) Homo sapiens GO:0006508~proteolysis,GO:0006919~activation of cysteine-type endopeptidase activity involved in apoptotic process,GO:0010724~regulation of definitive erythrocyte differentiation,GO:0016925~protein sumoylation,GO:0016926~protein desumoylation,GO:0032435~negative regulation of proteasomal ubiquitin-dependent protein catabolic process,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0097190~apoptotic signaling pathway, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005925~focal adhesion,GO:0031965~nuclear membrane, GO:0004175~endopeptidase activity,GO:0005515~protein binding,GO:0016929~SUMO-specific protease activity,GO:0070139~SUMO-specific endopeptidase activity, IPR003653:Peptidase C48, SUMO/Sentrin/Ubl1, 3D-structure,Alternative splicing,Complete proteome,Cytoplasm,Hydrolase,Nucleus,Phosphoprotein,Polymorphism,Protease,Proteomics identification,Reference proteome,Thiol protease,Ubl conjugation pathway, active site:Nucleophile,chain:Sentrin-specific protease 1,compositionally biased region:His-rich,compositionally biased region:Ser-rich,helix,modified residue,mutagenesis site,region of interest:Protease,sequence variant,short sequence motif:Nuclear export signal,short sequence motif:Nuclear localization signal,splice variant,strand,turn, Q8TAQ2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2(SMARCC2) Homo sapiens h_hSWI-SNFpathway:Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes,h_vdrPathway:Control of Gene Expression by Vitamin D Receptor, Chromatin structure and dynamics / Transcription,General function prediction only, GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0006337~nucleosome disassembly,GO:0006338~chromatin remodeling,GO:0006351~transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0016569~covalent chromatin modification,GO:0021882~regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment,GO:0043044~ATP-dependent chromatin remodeling,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated, GO:0000790~nuclear chromatin,GO:0005654~nucleoplasm,GO:0016514~SWI/SNF complex,GO:0017053~transcriptional repressor complex,GO:0043234~protein complex,GO:0071564~npBAF complex,GO:0071565~nBAF complex,GO:0090544~BAF-type complex, GO:0000978~RNA polymerase II core promoter proximal region sequence-specific DNA binding,GO:0000980~RNA polymerase II distal enhancer sequence-specific DNA binding,GO:0003677~DNA binding,GO:0003682~chromatin binding,GO:0003713~transcription coactivator activity,GO:0005515~protein binding,GO:0031492~nucleosomal DNA binding, IPR000953:Chromo domain/shadow,IPR001005:SANT/Myb domain,IPR001357:BRCT domain,IPR007526:SWIRM domain,IPR009057:Homeodomain-like,IPR011991:Winged helix-turn-helix DNA-binding domain,IPR017884:SANT domain, SM00298:CHROMO,SM00717:SANT, Acetylation,Alternative splicing,Chromatin regulator,Coiled coil,Complete proteome,Isopeptide bond,Neurogenesis,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Transcription,Transcription regulation,Ubl conjugation, chain:SWI/SNF complex subunit SMARCC2,compositionally biased region:Glu-rich,compositionally biased region:Poly-Ala,compositionally biased region:Poly-Gln,compositionally biased region:Poly-Glu,compositionally biased region:Pro-rich,domain:SANT,domain:SWIRM,modified residue,sequence conflict,splice variant, Q3TKT4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4(Smarca4) Mus musculus m_hSWI-SNFpathway:Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes,m_vdrPathway:Control of Gene Expression by Vitamin D Receptor, GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0000902~cell morphogenesis,GO:0001568~blood vessel development,GO:0001570~vasculogenesis,GO:0001701~in utero embryonic development,GO:0001832~blastocyst growth,GO:0001835~blastocyst hatching,GO:0001889~liver development,GO:0003151~outflow tract morphogenesis,GO:0003281~ventricular septum development,GO:0003407~neural retina development,GO:0006334~nucleosome assembly,GO:0006337~nucleosome disassembly,GO:0006338~chromatin remodeling,GO:0006346~methylation-dependent chromatin silencing,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007399~nervous system development,GO:0007403~glial cell fate determination,GO:0007507~heart development,GO:0008284~positive regulation of cell proliferation,GO:0010424~DNA methylation on cytosine within a CG sequence,GO:0016569~covalent chromatin modification,GO:0019827~stem cell population maintenance,GO:0022008~neurogenesis,GO:0030177~positive regulation of Wnt signaling pathway,GO:0030198~extracellular matrix organization,GO:0030216~keratinocyte differentiation,GO:0030308~negative regulation of cell growth,GO:0030334~regulation of cell migration,GO:0030900~forebrain development,GO:0030902~hindbrain development,GO:0035116~embryonic hindlimb morphogenesis,GO:0035887~aortic smooth muscle cell differentiation,GO:0035904~aorta development,GO:0043044~ATP-dependent chromatin remodeling,GO:0043066~negative regulation of apoptotic process,GO:0043388~positive regulation of DNA binding,GO:0043923~positive regulation by host of viral transcription,GO:0043966~histone H3 acetylation,GO:0045597~positive regulation of cell differentiation,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0048562~embryonic organ morphogenesis,GO:0048730~epidermis morphogenesis,GO:0051091~positive regulation of sequence-specific DNA binding transcription factor activity,GO:0060318~definitive erythrocyte differentiation,GO:0060347~heart trabecula formation,GO:0060766~negative regulation of androgen receptor signaling pathway,GO:0060976~coronary vasculature development,GO:0061626~pharyngeal arch artery morphogenesis,GO:0070307~lens fiber cell development,GO:1901838~positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter,GO:1902661~positive regulation of glucose mediated signaling pathway,GO:1902895~positive regulation of pri-miRNA transcription from RNA polymerase II promoter, GO:0000790~nuclear chromatin,GO:0000792~heterochromatin,GO:0005615~extracellular space,GO:0005634~nucleus,GO:0005719~nuclear euchromatin,GO:0005726~perichromatin fibrils,GO:0005730~nucleolus,GO:0016020~membrane,GO:0016514~SWI/SNF complex,GO:0043234~protein complex,GO:0071564~npBAF complex,GO:0071565~nBAF complex,GO:0090544~BAF-type complex, GO:0000166~nucleotide binding,GO:0000977~RNA polymerase II regulatory region sequence-specific DNA binding,GO:0000978~RNA polymerase II core promoter proximal region sequence-specific DNA binding,GO:0000980~RNA polymerase II distal enhancer sequence-specific DNA binding,GO:0001105~RNA polymerase II transcription coactivator activity,GO:0001164~RNA polymerase I CORE element sequence-specific DNA binding,GO:0002039~p53 binding,GO:0003682~chromatin binding,GO:0003713~transcription coactivator activity,GO:0003714~transcription corepressor activity,GO:0004386~helicase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008094~DNA-dependent ATPase activity,GO:0008134~transcription factor binding,GO:0016787~hydrolase activity,GO:0016817~hydrolase activity, acting on acid anhydrides,GO:0016887~ATPase activity,GO:0030957~Tat protein binding,GO:0031492~nucleosomal DNA binding,GO:0032403~protein complex binding,GO:0042393~histone binding,GO:0047485~protein N-terminus binding,GO:0050681~androgen receptor binding,GO:0070182~DNA polymerase binding,GO:0070577~lysine-acetylated histone binding, IPR000330:SNF2-related,IPR001487:Bromodomain,IPR001650:Helicase, C-terminal,IPR006576:BRK domain,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR014012:Helicase/SANT-associated, DNA binding,IPR014978:Glutamine-Leucine-Glutamine, QLQ,IPR018359:Bromodomain, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00297:BROMO,SM00487:DEXDc,SM00490:HELICc,SM00573:HSA,SM00592:BRK,SM00951:SM00951,SM01314:SM01314, Acetylation,Activator,Alternative splicing,ATP-binding,Bromodomain,Chromatin regulator,Coiled coil,Complete proteome,Helicase,Hydrolase,Neurogenesis,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repressor,Transcription,Transcription regulation, chain:Transcription activator BRG1,compositionally biased region:Glu-rich,compositionally biased region:Poly-Glu,compositionally biased region:Pro-rich,domain:Bromo,domain:Helicase ATP-binding,domain:Helicase C-terminal,domain:HSA,modified residue,nucleotide phosphate-binding region:ATP,region of interest:Necessary for interaction with SS18L1/CREST,sequence conflict,short sequence motif:DEGH box,site:Required for binding to 'Lys-15'- acetylated histone 3,splice variant, Q5FWR0 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1(smarcad1) Xenopus tropicalis GO:0000729~DNA double-strand break processing,GO:0016569~covalent chromatin modification,GO:0043044~ATP-dependent chromatin remodeling, GO:0005634~nucleus,GO:0035861~site of double-strand break, GO:0003677~DNA binding,GO:0004386~helicase activity,GO:0005524~ATP binding, IPR000330:SNF2-related,IPR001650:Helicase, C-terminal,IPR003892:Ubiquitin system component Cue,IPR009060:UBA-like,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00487:DEXDc,SM00490:HELICc, ATP-binding,Chromatin regulator,Chromosome,Complete proteome,DNA damage,DNA repair,DNA-binding,Helicase,Hydrolase,Nucleotide-binding,Nucleus,Reference proteome, Q5VUG0 Scm-like with four mbt domains 2(SFMBT2) Homo sapiens GO:0006355~regulation of transcription, DNA-templated,GO:0010629~negative regulation of gene expression, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0016235~aggresome,GO:0043231~intracellular membrane-bounded organelle, GO:0005515~protein binding,GO:0042393~histone binding, IPR001660:Sterile alpha motif domain,IPR004092:Mbt repeat,IPR013761:Sterile alpha motif/pointed domain,IPR021987:Protein of unknown function DUF3588, SM00454:SAM,SM00561:MBT, 3D-structure,Complete proteome,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Repeat,Repressor, chain:Scm-like with four MBT domains protein 2,domain:SAM,helix,repeat:MBT 1,repeat:MBT 2,repeat:MBT 3,repeat:MBT 4,sequence variant,strand,turn, Q7SZE5 Sec23 homolog A, COPII coat complex component(sec23a) Danio rerio Intracellular trafficking and secretion, GO:0006810~transport,GO:0006886~intracellular protein transport,GO:0006888~ER to Golgi vesicle-mediated transport,GO:0015031~protein transport,GO:0016192~vesicle-mediated transport,GO:0035138~pectoral fin morphogenesis,GO:0048702~embryonic neurocranium morphogenesis,GO:0051216~cartilage development, GO:0000139~Golgi membrane,GO:0005783~endoplasmic reticulum,GO:0005794~Golgi apparatus,GO:0016020~membrane,GO:0030127~COPII vesicle coat,GO:0030868~smooth endoplasmic reticulum membrane, GO:0008270~zinc ion binding, IPR002035:von Willebrand factor, type A,IPR006895:Zinc finger, Sec23/Sec24-type,IPR006896:Sec23/Sec24, trunk domain,IPR006900:Sec23/Sec24, helical domain,IPR007123:Gelsolin domain,IPR012990:Sec23/Sec24 beta-sandwich, dre04141:Protein processing in endoplasmic reticulum, Complete proteome,Endoplasmic reticulum,ER-Golgi transport,Golgi apparatus,Membrane,Protein transport,Reference proteome,Transport, chain:Protein transport protein Sec23A,sequence conflict, Q23356 Serine/threonine-protein kinase mig-15(mig-15) Caenorhabditis elegans GO:0000003~reproduction,GO:0002119~nematode larval development,GO:0006468~protein phosphorylation,GO:0006898~receptor-mediated endocytosis,GO:0007165~signal transduction,GO:0010171~body morphogenesis,GO:0016310~phosphorylation,GO:0016477~cell migration,GO:0018991~oviposition,GO:0019915~lipid storage,GO:0023014~signal transduction by protein phosphorylation,GO:0030334~regulation of cell migration,GO:0032228~regulation of synaptic transmission, GABAergic,GO:0033563~dorsal/ventral axon guidance,GO:0040011~locomotion,GO:0040035~hermaphrodite genitalia development,GO:0040039~inductive cell migration,GO:0048675~axon extension,GO:0048812~neuron projection morphogenesis, GO:0005737~cytoplasm, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0004702~receptor signaling protein serine/threonine kinase activity,GO:0004871~signal transducer activity,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0016740~transferase activity, IPR000719:Protein kinase, catalytic domain,IPR001180:Citron-like,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, SM00036:CNH,SM00220:S_TKc, Alternative splicing,ATP-binding,Complete proteome,Kinase,Nucleotide-binding,Reference proteome,Serine/threonine-protein kinase,Transducer,Transferase, active site:Proton acceptor,binding site:ATP,chain:Serine/threonine-protein kinase mig-15,domain:CNH,domain:Protein kinase,nucleotide phosphate-binding region:ATP,splice variant, Q86DA5 Sterile alpha and TIR motif-containing protein tir-1(tir-1) Caenorhabditis elegans GO:0000003~reproduction,GO:0000187~activation of MAPK activity,GO:0002119~nematode larval development,GO:0002376~immune system process,GO:0006898~receptor-mediated endocytosis,GO:0006952~defense response,GO:0007165~signal transduction,GO:0007275~multicellular organism development,GO:0007399~nervous system development,GO:0007411~axon guidance,GO:0008104~protein localization,GO:0008340~determination of adult lifespan,GO:0009792~embryo development ending in birth or egg hatching,GO:0030154~cell differentiation,GO:0033554~cellular response to stress,GO:0040007~growth,GO:0042742~defense response to bacterium,GO:0045087~innate immune response,GO:0045168~cell-cell signaling involved in cell fate commitment,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0050832~defense response to fungus,GO:1902097~positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium, GO:0005737~cytoplasm,GO:1904115~axon cytoplasm, GO:0005515~protein binding,GO:0017137~Rab GTPase binding,GO:0019901~protein kinase binding,GO:0035591~signaling adaptor activity,GO:0042802~identical protein binding, IPR000157:Toll/interleukin-1 receptor homology (TIR) domain,IPR001660:Sterile alpha motif domain,IPR011989:Armadillo-like helical,IPR013761:Sterile alpha motif/pointed domain,IPR016024:Armadillo-type fold, SM00255:TIR,SM00454:SAM, Alternative splicing,Complete proteome,Cytoplasm,Developmental protein,Differentiation,Immunity,Innate immunity,Neurogenesis,Proteomics identification,Receptor,Reference proteome,Repeat, chain:Sterile alpha and TIR motif-containing protein tir-1,compositionally biased region:Pro-rich,domain:SAM 1,domain:SAM 2,domain:TIR,splice variant, Q5BKE0 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor(Taf9) Rattus norvegicus GO:0000492~box C/D snoRNP assembly,GO:0006352~DNA-templated transcription, initiation,GO:0030307~positive regulation of cell growth,GO:0032435~negative regulation of proteasomal ubiquitin-dependent protein catabolic process,GO:0043066~negative regulation of apoptotic process,GO:0043966~histone H3 acetylation,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0050821~protein stabilization,GO:0051123~RNA polymerase II transcriptional preinitiation complex assembly,GO:0060760~positive regulation of response to cytokine stimulus,GO:0070555~response to interleukin-1,GO:1902065~response to L-glutamate, GO:0000124~SAGA complex,GO:0000125~PCAF complex,GO:0005634~nucleus,GO:0005669~transcription factor TFIID complex,GO:0030914~STAGA complex,GO:0033276~transcription factor TFTC complex,GO:0070761~pre-snoRNP complex,GO:0071339~MLL1 complex, GO:0001075~transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly,GO:0002039~p53 binding,GO:0003677~DNA binding,GO:0003713~transcription coactivator activity,GO:0004402~histone acetyltransferase activity,GO:0005515~protein binding,GO:0008134~transcription factor binding,GO:0033613~activating transcription factor binding,GO:0044212~transcription regulatory region DNA binding,GO:0046982~protein heterodimerization activity,GO:0051117~ATPase binding,GO:0070742~C2H2 zinc finger domain binding, IPR003162:Transcription factor TAFII-31,IPR009072:Histone-fold, rno03022:Basal transcription factors, Acetylation,Complete proteome,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Transcription,Transcription regulation, chain:Adenylate kinase isoenzyme 6,chain:Transcription initiation factor TFIID subunit 9,compositionally biased region:Poly-Asp,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict, Q9UHD2 TANK binding kinase 1(TBK1) Homo sapiens GO:0006954~inflammatory response,GO:0007249~I-kappaB kinase/NF-kappaB signaling,GO:0009615~response to virus,GO:0010629~negative regulation of gene expression,GO:0018105~peptidyl-serine phosphorylation,GO:0032480~negative regulation of type I interferon production,GO:0032481~positive regulation of type I interferon production,GO:0032606~type I interferon production,GO:0032727~positive regulation of interferon-alpha production,GO:0032728~positive regulation of interferon-beta production,GO:0033138~positive regulation of peptidyl-serine phosphorylation,GO:0035666~TRIF-dependent toll-like receptor signaling pathway,GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling,GO:0044565~dendritic cell proliferation,GO:0045087~innate immune response,GO:0045359~positive regulation of interferon-beta biosynthetic process,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0050830~defense response to Gram-positive bacterium,GO:0051607~defense response to virus,GO:1901214~regulation of neuron death,GO:1904417~positive regulation of xenophagy, GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0010008~endosome membrane, GO:0003676~nucleic acid binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0051219~phosphoprotein binding, IPR000719:Protein kinase, catalytic domain,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, hsa04014:Ras signaling pathway,hsa04620:Toll-like receptor signaling pathway,hsa04622:RIG-I-like receptor signaling pathway,hsa04623:Cytosolic DNA-sensing pathway,hsa05160:Hepatitis C,hsa05161:Hepatitis B,hsa05162:Measles,hsa05164:Influenza A,hsa05168:Herpes simplex infection,hsa05169:Epstein-Barr virus infection, 616439~Frontotemporal dementia and/or amyotrophic lateral sclerosis 4, SM00220:S_TKc, 3D-structure,Amyotrophic lateral sclerosis,Antiviral defense,ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Disease mutation,Glaucoma,Host-virus interaction,Immunity,Innate immunity,Isopeptide bond,Kinase,Neurodegeneration,Nucleotide-binding,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Serine/threonine-protein kinase,Transferase,Ubl conjugation, active site:Proton acceptor,binding site:ATP,chain:Serine/threonine-protein kinase TBK1,domain:Protein kinase,modified residue,mutagenesis site,nucleotide phosphate-binding region:ATP,sequence variant, Q8C092 TATA-box binding protein associated factor 5(Taf5) Mus musculus GO:0006351~transcription, DNA-templated,GO:0006352~DNA-templated transcription, initiation,GO:0006355~regulation of transcription, DNA-templated,GO:0006367~transcription initiation from RNA polymerase II promoter,GO:0016573~histone acetylation, GO:0000790~nuclear chromatin,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005669~transcription factor TFIID complex,GO:0015629~actin cytoskeleton,GO:0033276~transcription factor TFTC complex,GO:0043231~intracellular membrane-bounded organelle, GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0004402~histone acetyltransferase activity,GO:0044212~transcription regulatory region DNA binding,GO:0046983~protein dimerization activity, IPR001680:WD40 repeat,IPR006594:LisH dimerisation motif,IPR007582:TFIID subunit, WD40-associated region,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site,IPR020472:G-protein beta WD-40 repeat, mmu03022:Basal transcription factors,mmu05168:Herpes simplex infection, SM00320:WD40, Coiled coil,Complete proteome,Nucleus,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,WD repeat, chain:Transcription initiation factor TFIID subunit 5,domain:LisH,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,sequence conflict, Q91857 TATA-box binding protein associated factor 6 L homeolog(taf6.L) Xenopus laevis Transcription, GO:0006352~DNA-templated transcription, initiation,GO:0051090~regulation of sequence-specific DNA binding transcription factor activity, GO:0071339~MLL1 complex, IPR004823:TATA box binding protein associated factor (TAF),IPR009072:Histone-fold,IPR011442:Domain of unknown function DUF1546,IPR016024:Armadillo-type fold, xla03022:Basal transcription factors,xla05168:Herpes simplex infection, SM00803:TAF, Nucleus,Transcription,Transcription regulation, chain:Transcription initiation factor TFIID subunit 6,compositionally biased region:Poly-Pro,sequence conflict, Q17QQ4 TATA-box binding protein associated factor 9(TAF9) Bos taurus GO:0000492~box C/D snoRNP assembly,GO:0006366~transcription from RNA polymerase II promoter,GO:0030307~positive regulation of cell growth,GO:0032435~negative regulation of proteasomal ubiquitin-dependent protein catabolic process,GO:0043066~negative regulation of apoptotic process,GO:0043966~histone H3 acetylation,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0050821~protein stabilization,GO:0051123~RNA polymerase II transcriptional preinitiation complex assembly,GO:0060760~positive regulation of response to cytokine stimulus,GO:0070555~response to interleukin-1, GO:0000124~SAGA complex,GO:0000125~PCAF complex,GO:0005669~transcription factor TFIID complex,GO:0030914~STAGA complex,GO:0033276~transcription factor TFTC complex,GO:0070761~pre-snoRNP complex,GO:0071339~MLL1 complex, GO:0001075~transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly,GO:0002039~p53 binding,GO:0003713~transcription coactivator activity,GO:0004402~histone acetyltransferase activity,GO:0008134~transcription factor binding,GO:0033613~activating transcription factor binding,GO:0044212~transcription regulatory region DNA binding,GO:0046982~protein heterodimerization activity,GO:0051117~ATPase binding,GO:0070742~C2H2 zinc finger domain binding, IPR003162:Transcription factor TAFII-31,IPR009072:Histone-fold, bta03022:Basal transcription factors, Acetylation,Complete proteome,Nucleus,Phosphoprotein,Reference proteome,Transcription,Transcription regulation, chain:Adenylate kinase isoenzyme 6,chain:Transcription initiation factor TFIID subunit 9,compositionally biased region:Poly-Asp,modified residue,nucleotide phosphate-binding region:ATP, Q5RHR6 TBC1 domain family, member 32(tbc1d32) Danio rerio GO:0007275~multicellular organism development,GO:0035082~axoneme assembly,GO:0060271~cilium morphogenesis, GO:0005737~cytoplasm,GO:0005929~cilium,GO:0042995~cell projection, IPR000195:Rab-GTPase-TBC domain, Cell projection,Cilium,Complete proteome,Cytoplasm,Developmental protein,Reference proteome, chain:Uncharacterized protein C6orf170 homolog, A4QP31 TBCC domain containing 1(tbccd1) Danio rerio GO:0000902~cell morphogenesis, GO:0000922~spindle pole,GO:0005737~cytoplasm,GO:0005815~microtubule organizing center,GO:0005856~cytoskeleton, IPR006599:CARP motif,IPR012945:Tubulin binding cofactor C,IPR016098:Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal,IPR017901:C-CAP/cofactor C-like domain, SM00673:CARP, Complete proteome,Cytoplasm,Cytoskeleton,Proteomics identification,Reference proteome, chain:TBCC domain-containing protein 1,domain:C-CAP/cofactor C-like,sequence conflict, Q7Z3E1 TCDD inducible poly(ADP-ribose) polymerase(TIPARP) Homo sapiens GO:0001570~vasculogenesis,GO:0001822~kidney development,GO:0006471~protein ADP-ribosylation,GO:0006807~nitrogen compound metabolic process,GO:0008209~androgen metabolic process,GO:0008210~estrogen metabolic process,GO:0008585~female gonad development,GO:0009791~post-embryonic development,GO:0010629~negative regulation of gene expression,GO:0030097~hemopoiesis,GO:0044236~multicellular organism metabolic process,GO:0045732~positive regulation of protein catabolic process,GO:0048008~platelet-derived growth factor receptor signaling pathway,GO:0048705~skeletal system morphogenesis,GO:0048745~smooth muscle tissue development,GO:0060021~palate development,GO:0060325~face morphogenesis,GO:0071407~cellular response to organic cyclic compound, GO:0005634~nucleus, GO:0003950~NAD+ ADP-ribosyltransferase activity,GO:0035326~enhancer binding,GO:0046872~metal ion binding, IPR000571:Zinc finger, CCCH-type,IPR004170:WWE domain,IPR012317:Poly(ADP-ribose) polymerase, catalytic domain, Complete proteome,Glycosyltransferase,Metal-binding,NAD,Polymorphism,Reference proteome,Transferase,Zinc,Zinc-finger, chain:TCDD-inducible poly [ADP-ribose] polymerase,domain:PARP catalytic,domain:WWE,sequence conflict,sequence variant,zinc finger region:C3H1-type, Q5EAN7 TERF2 interacting protein(Terf2ip) Rattus norvegicus GO:0000723~telomere maintenance,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0010569~regulation of double-strand break repair via homologous recombination,GO:0010833~telomere maintenance via telomere lengthening,GO:0031848~protection from non-homologous end joining at telomere,GO:0032205~negative regulation of telomere maintenance,GO:0033138~positive regulation of peptidyl-serine phosphorylation,GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling,GO:0048239~negative regulation of DNA recombination at telomere,GO:0051092~positive regulation of NF-kappaB transcription factor activity,GO:0070198~protein localization to chromosome, telomeric region,GO:1901985~positive regulation of protein acetylation, GO:0000781~chromosome, telomeric region,GO:0000783~nuclear telomere cap complex,GO:0000784~nuclear chromosome, telomeric region,GO:0005634~nucleus,GO:0005635~nuclear envelope,GO:0005737~cytoplasm,GO:0030870~Mre11 complex,GO:0070187~telosome, GO:0042162~telomeric DNA binding,GO:0098505~G-rich strand telomeric DNA binding, IPR001357:BRCT domain,IPR009057:Homeodomain-like,IPR015010:Rap1 Myb domain,IPR021661:Rap1 - C-terminal, Acetylation,Activator,Chromosome,Complete proteome,Cytoplasm,Isopeptide bond,Nucleus,Phosphoprotein,Reference proteome,Telomere,Transcription,Transcription regulation,Ubl conjugation, Q15750 TGF-beta activated kinase 1 (MAP3K7) binding protein 1(TAB1) Homo sapiens h_il1rPathway:Signal transduction through IL1R,h_nfkbPathway:NF-kB Signaling Pathway,h_tgfbPathway:TGF beta signaling pathway,h_tollPathway:Toll-Like Receptor Pathway,h_wntPathway:WNT Signaling Pathway, GO:0000185~activation of MAPKKK activity,GO:0000187~activation of MAPK activity,GO:0001701~in utero embryonic development,GO:0002223~stimulatory C-type lectin receptor signaling pathway,GO:0002755~MyD88-dependent toll-like receptor signaling pathway,GO:0003007~heart morphogenesis,GO:0003279~cardiac septum development,GO:0006470~protein dephosphorylation,GO:0007179~transforming growth factor beta receptor signaling pathway,GO:0007249~I-kappaB kinase/NF-kappaB signaling,GO:0007254~JNK cascade,GO:0030324~lung development,GO:0035904~aorta development,GO:0038095~Fc-epsilon receptor signaling pathway,GO:0043406~positive regulation of MAP kinase activity,GO:0051092~positive regulation of NF-kappaB transcription factor activity,GO:0060976~coronary vasculature development,GO:0070423~nucleotide-binding oligomerization domain containing signaling pathway, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0010008~endosome membrane,GO:0043234~protein complex, GO:0004722~protein serine/threonine phosphatase activity,GO:0005515~protein binding,GO:0008047~enzyme activator activity,GO:0016301~kinase activity,GO:0019209~kinase activator activity,GO:0032403~protein complex binding,GO:0048273~mitogen-activated protein kinase p38 binding, IPR001932:Protein phosphatase 2C (PP2C)-like,IPR015655:Protein phosphatase 2C, hsa04010:MAPK signaling pathway,hsa04064:NF-kappa B signaling pathway,hsa04380:Osteoclast differentiation,hsa04620:Toll-like receptor signaling pathway,hsa04621:NOD-like receptor signaling pathway,hsa04668:TNF signaling pathway,hsa05140:Leishmaniasis,hsa05145:Toxoplasmosis,hsa05168:Herpes simplex infection,hsa05169:Epstein-Barr virus infection, SM00332:PP2Cc, 3D-structure,Alternative splicing,Complete proteome,Kinase,Phosphoprotein,Polymorphism,Reference proteome,Transferase,Ubl conjugation, chain:Mitogen-activated protein kinase kinase kinase 7-interacting protein 1,compositionally biased region:Poly-Ser,domain:PP2C-like,helix,modified residue,mutagenesis site,sequence variant,strand,turn, A5PKF5 THAP domain containing 11(THAP11) Bos taurus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0045171~intercellular bridge, GO:0003677~DNA binding,GO:0008270~zinc ion binding, IPR006612:Zinc finger, C2CH-type, SM00692:DM3,SM00980:SM00980, Coiled coil,Complete proteome,Cytoplasm,DNA-binding,Metal-binding,Nucleus,Reference proteome,Repressor,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:THAP domain-containing protein 11,compositionally biased region:Ala-rich,compositionally biased region:Poly-Ala,compositionally biased region:Poly-Gln,modified residue,zinc finger region:THAP-type, Q96FV9 THO complex 1(THOC1) Homo sapiens GO:0000018~regulation of DNA recombination,GO:0006369~termination of RNA polymerase II transcription,GO:0006396~RNA processing,GO:0006405~RNA export from nucleus,GO:0006406~mRNA export from nucleus,GO:0006915~apoptotic process,GO:0007165~signal transduction,GO:0008380~RNA splicing,GO:0031124~mRNA 3'-end processing,GO:0031297~replication fork processing,GO:0032784~regulation of DNA-templated transcription, elongation,GO:0032786~positive regulation of DNA-templated transcription, elongation,GO:0046784~viral mRNA export from host cell nucleus,GO:0048297~negative regulation of isotype switching to IgA isotypes,GO:2000002~negative regulation of DNA damage checkpoint, GO:0000346~transcription export complex,GO:0000347~THO complex,GO:0000445~THO complex part of transcription export complex,GO:0000784~nuclear chromosome, telomeric region,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0016363~nuclear matrix,GO:0016607~nuclear speck,GO:0045171~intercellular bridge, GO:0003677~DNA binding,GO:0003723~RNA binding,GO:0005515~protein binding, IPR000488:Death domain,IPR011029:Death-like domain,IPR021861:THO complex, subunit THOC1, hsa03013:RNA transport,hsa03040:Spliceosome, SM00005:DEATH, 3D-structure,Acetylation,Alternative splicing,Apoptosis,Complete proteome,Cytoplasm,DNA-binding,Isopeptide bond,mRNA processing,mRNA splicing,mRNA transport,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,RNA-binding,Transcription,Transcription regulation,Transport,Ubl conjugation, chain:THO complex subunit 1,domain:Death,helix,modified residue,mutagenesis site,sequence conflict,short sequence motif:Nuclear localization signal,splice variant,strand,turn, P21580 TNF alpha induced protein 3(TNFAIP3) Homo sapiens h_cd40Pathway:CD40L Signaling Pathway,h_nfkbPathway:NF-kB Signaling Pathway,h_tnfr2Pathway:TNFR2 Signaling Pathway, GO:0001922~B-1 B cell homeostasis,GO:0002237~response to molecule of bacterial origin,GO:0002634~regulation of germinal center formation,GO:0002677~negative regulation of chronic inflammatory response,GO:0006915~apoptotic process,GO:0006954~inflammatory response,GO:0010803~regulation of tumor necrosis factor-mediated signaling pathway,GO:0016567~protein ubiquitination,GO:0016579~protein deubiquitination,GO:0031397~negative regulation of protein ubiquitination,GO:0032088~negative regulation of NF-kappaB transcription factor activity,GO:0032480~negative regulation of type I interferon production,GO:0032495~response to muramyl dipeptide,GO:0032691~negative regulation of interleukin-1 beta production,GO:0032703~negative regulation of interleukin-2 production,GO:0032715~negative regulation of interleukin-6 production,GO:0032720~negative regulation of tumor necrosis factor production,GO:0034136~negative regulation of toll-like receptor 2 signaling pathway,GO:0034140~negative regulation of toll-like receptor 3 signaling pathway,GO:0034144~negative regulation of toll-like receptor 4 signaling pathway,GO:0034148~negative regulation of toll-like receptor 5 signaling pathway,GO:0035871~protein K11-linked deubiquitination,GO:0043124~negative regulation of I-kappaB kinase/NF-kappaB signaling,GO:0045732~positive regulation of protein catabolic process,GO:0045736~negative regulation of cyclin-dependent protein serine/threonine kinase activity,GO:0045779~negative regulation of bone resorption,GO:0045824~negative regulation of innate immune response,GO:0048662~negative regulation of smooth muscle cell proliferation,GO:0050691~regulation of defense response to virus by host,GO:0050727~regulation of inflammatory response,GO:0050728~negative regulation of inflammatory response,GO:0050869~negative regulation of B cell activation,GO:0051259~protein oligomerization,GO:0061043~regulation of vascular wound healing,GO:0070301~cellular response to hydrogen peroxide,GO:0070423~nucleotide-binding oligomerization domain containing signaling pathway,GO:0070429~negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway,GO:0070433~negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway,GO:0070536~protein K63-linked deubiquitination,GO:0070936~protein K48-linked ubiquitination,GO:0071108~protein K48-linked deubiquitination,GO:0071222~cellular response to lipopolysaccharide,GO:0071947~protein deubiquitination involved in ubiquitin-dependent protein catabolic process,GO:0072573~tolerance induction to lipopolysaccharide,GO:0072666~establishment of protein localization to vacuole,GO:0090291~negative regulation of osteoclast proliferation,GO:1902042~negative regulation of extrinsic apoptotic signaling pathway via death domain receptors,GO:1903364~positive regulation of cellular protein catabolic process,GO:2000347~positive regulation of hepatocyte proliferation,GO:2000349~negative regulation of CD40 signaling pathway,GO:2000352~negative regulation of endothelial cell apoptotic process, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005764~lysosome,GO:0005829~cytosol,GO:0070062~extracellular exosome, GO:0002020~protease binding,GO:0003677~DNA binding,GO:0004842~ubiquitin-protein transferase activity,GO:0004843~thiol-dependent ubiquitin-specific protease activity,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0019900~kinase binding,GO:0042802~identical protein binding,GO:0043130~ubiquitin binding,GO:0043621~protein self-association,GO:0070530~K63-linked polyubiquitin binding, IPR002653:Zinc finger, A20-type,IPR003323:Ovarian tumour, otubain, hsa04064:NF-kappa B signaling pathway,hsa04621:NOD-like receptor signaling pathway,hsa04668:TNF signaling pathway,hsa05162:Measles,hsa05169:Epstein-Barr virus infection, SM00259:ZnF_A20, 3D-structure,Acetylation,Apoptosis,Complete proteome,Cytoplasm,Disease mutation,DNA-binding,Hydrolase,Inflammatory response,Ligase,Lysosome,Metal-binding,Multifunctional enzyme,Nucleus,Phosphoprotein,Polymorphism,Protease,Proteomics identification,Reference proteome,Repeat,Thiol protease,Ubl conjugation pathway,Zinc,Zinc-finger, chain:Tumor necrosis factor, alpha-induced protein 3,domain:OTU,helix,modified residue,mutagenesis site,region of interest:2 X approximate repeats,region of interest:Interaction with NAF1,region of interest:TRAF-binding,repeat:1,repeat:2,sequence variant,strand,turn,zinc finger region:A20-type 1,zinc finger region:A20-type 2,zinc finger region:A20-type 3,zinc finger region:A20-type 4,zinc finger region:A20-type 5,zinc finger region:A20-type 6,zinc finger region:A20-type 7, Q13114 TNF receptor associated factor 3(TRAF3) Homo sapiens 51.CD40_and_EBV, h_cd40Pathway:CD40L Signaling Pathway,h_tall1Pathway:TACI and BCMA stimulation of B cell immune responses.,h_tnfr2Pathway:TNFR2 Signaling Pathway, Cell division and chromosome partitioning, GO:0001817~regulation of cytokine production,GO:0002224~toll-like receptor signaling pathway,GO:0006915~apoptotic process,GO:0007165~signal transduction,GO:0008063~Toll signaling pathway,GO:0016567~protein ubiquitination,GO:0030162~regulation of proteolysis,GO:0032088~negative regulation of NF-kappaB transcription factor activity,GO:0032480~negative regulation of type I interferon production,GO:0032648~regulation of interferon-beta production,GO:0033209~tumor necrosis factor-mediated signaling pathway,GO:0035666~TRIF-dependent toll-like receptor signaling pathway,GO:0042981~regulation of apoptotic process,GO:0045087~innate immune response,GO:0050688~regulation of defense response to virus, GO:0005739~mitochondrion,GO:0005768~endosome,GO:0005829~cytosol,GO:0009898~cytoplasmic side of plasma membrane,GO:0035631~CD40 receptor complex, GO:0004842~ubiquitin-protein transferase activity,GO:0004871~signal transducer activity,GO:0005164~tumor necrosis factor receptor binding,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0019901~protein kinase binding,GO:0019903~protein phosphatase binding,GO:0031625~ubiquitin protein ligase binding,GO:0031996~thioesterase binding, IPR001293:Zinc finger, TRAF-type,IPR001841:Zinc finger, RING-type,IPR002083:MATH,IPR008974:TRAF-like,IPR012227:TNF receptor-associated factor TRAF,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR013323:SIAH-type domain,IPR017907:Zinc finger, RING-type, conserved site,IPR018957:Zinc finger, C3HC4 RING-type,IPR027128:TNF receptor-associated factor 3, hsa04064:NF-kappa B signaling pathway,hsa04620:Toll-like receptor signaling pathway,hsa04622:RIG-I-like receptor signaling pathway,hsa04668:TNF signaling pathway,hsa05160:Hepatitis C,hsa05168:Herpes simplex infection,hsa05169:Epstein-Barr virus infection,hsa05200:Pathways in cancer,hsa05203:Viral carcinogenesis,hsa05222:Small cell lung cancer, 614849~Herpes simplex encephalitis, susceptibility to, 3, PIRSF015614:TNF receptor-associated factor (TRAF), SM00061:MATH, 3D-structure,Alternative splicing,Apoptosis,Coiled coil,Complete proteome,Cytoplasm,Disease mutation,Endosome,Immunity,Ligase,Metal-binding,Mitochondrion,Phosphoprotein,Polymorphism,Proteomics identification,Receptor,Reference proteome,Repeat,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, chain:TNF receptor-associated factor 3,domain:MATH,helix,sequence conflict,sequence variant,strand,turn,zinc finger region:RING-type,zinc finger region:TRAF-type 1,zinc finger region:TRAF-type 2, Q9CQN1 TNF receptor-associated protein 1(Trap1) Mus musculus GO:0006457~protein folding,GO:0006950~response to stress,GO:0009386~translational attenuation,GO:1901856~negative regulation of cellular respiration,GO:1903751~negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide, GO:0005654~nucleoplasm,GO:0005739~mitochondrion,GO:0005743~mitochondrial inner membrane,GO:0005758~mitochondrial intermembrane space,GO:0005759~mitochondrial matrix,GO:0005811~lipid particle,GO:0016020~membrane,GO:0070062~extracellular exosome, GO:0000166~nucleotide binding,GO:0005524~ATP binding,GO:0019901~protein kinase binding,GO:0044822~poly(A) RNA binding,GO:0051082~unfolded protein binding, IPR001404:Heat shock protein Hsp90,IPR003594:Histidine kinase-like ATPase, ATP-binding domain,IPR020568:Ribosomal protein S5 domain 2-type fold,IPR020575:Heat shock protein Hsp90, N-terminal, PIRSF002583:heat shock protein, HSP90/HTPG types, SM00387:HATPase_c, Acetylation,ATP-binding,Chaperone,Complete proteome,Direct protein sequencing,Membrane,Mitochondrion,Mitochondrion inner membrane,Nucleotide-binding,Phosphoprotein,Reference proteome,Transit peptide, binding site:ATP,binding site:ATP; via amide nitrogen,chain:Heat shock protein 75 kDa, mitochondrial,modified residue,transit peptide:Mitochondrion, Q15025 TNFAIP3 interacting protein 1(TNIP1) Homo sapiens GO:0002755~MyD88-dependent toll-like receptor signaling pathway,GO:0006412~translation,GO:0006508~proteolysis,GO:0006952~defense response,GO:0006954~inflammatory response,GO:0007159~leukocyte cell-cell adhesion,GO:0009101~glycoprotein biosynthetic process,GO:0043124~negative regulation of I-kappaB kinase/NF-kappaB signaling,GO:0045071~negative regulation of viral genome replication,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0050727~regulation of inflammatory response,GO:0050729~positive regulation of inflammatory response,GO:0070373~negative regulation of ERK1 and ERK2 cascade,GO:0085032~modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade, GO:0005622~intracellular,GO:0005654~nucleoplasm,GO:0005737~cytoplasm, GO:0004843~thiol-dependent ubiquitin-specific protease activity,GO:0005515~protein binding,GO:0042802~identical protein binding,GO:0051019~mitogen-activated protein kinase binding, Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Inflammatory response,Methylation,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:TNFAIP3-interacting protein 1,compositionally biased region:Pro-rich,modified residue,region of interest:Interacts with Nef,sequence conflict,sequence variant,short sequence motif:Nuclear localization signal,splice variant, Q59H18 TNNI3 interacting kinase(TNNI3K) Homo sapiens General function prediction only, GO:0002027~regulation of heart rate,GO:0006468~protein phosphorylation,GO:0055117~regulation of cardiac muscle contraction,GO:0086069~bundle of His cell to Purkinje myocyte communication,GO:1903779~regulation of cardiac conduction, GO:0005634~nucleus,GO:0005737~cytoplasm, GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008022~protein C-terminus binding,GO:0031013~troponin I binding,GO:0046872~metal ion binding, IPR000719:Protein kinase, catalytic domain,IPR001245:Serine-threonine/tyrosine-protein kinase catalytic domain,IPR002110:Ankyrin repeat,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site,IPR020683:Ankyrin repeat-containing domain, 616117~Cardiac conduction disease with or without dilated cardiomyopathy, SM00248:ANK, 3D-structure,Alternative splicing,ANK repeat,ATP-binding,Cardiomyopathy,Coiled coil,Complete proteome,Cytoplasm,Disease mutation,Kinase,Magnesium,Metal-binding,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Reference proteome,Repeat,Serine/threonine-protein kinase,Transferase, active site:Proton acceptor,binding site:ATP,chain:Fucose-1-phosphate guanylyltransferase,chain:Serine/threonine-protein kinase TNNI3K,compositionally biased region:Poly-Ser,domain:Protein kinase,modified residue,mutagenesis site,nucleotide phosphate-binding region:ATP,repeat:ANK 1,repeat:ANK 10,repeat:ANK 2,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5,repeat:ANK 6,repeat:ANK 7,repeat:ANK 8,repeat:ANK 9,sequence conflict,sequence variant,splice variant, Q54KD0 TPR repeat-containing protein(DDB_G0287407) Dictyostelium discoideum AX4 IPR011990:Tetratricopeptide-like helical,IPR013026:Tetratricopeptide repeat-containing domain,IPR014756:Immunoglobulin E-set,IPR019734:Tetratricopeptide repeat,IPR025139:Domain of unknown function DUF4062,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00028:TPR, Coiled coil,Complete proteome,Reference proteome,Repeat,TPR repeat, Q3KRG3 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)(tsr2) Danio rerio GO:0000462~maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA),GO:0006364~rRNA processing, GO:0005634~nucleus, IPR019398:Pre-rRNA-processing protein TSR2, Complete proteome,Proteomics identification,Reference proteome,rRNA processing, chain:Pre-rRNA-processing protein TSR2 homolog,compositionally biased region:Poly-Asp,compositionally biased region:Poly-Glu,sequence conflict, Q93075 TatD DNase domain containing 2(TATDN2) Homo sapiens GO:0006308~DNA catabolic process,GO:0036498~IRE1-mediated unfolded protein response,GO:0090305~nucleic acid phosphodiester bond hydrolysis, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm, GO:0004536~deoxyribonuclease activity,GO:0016888~endodeoxyribonuclease activity, producing 5'-phosphomonoesters,GO:0046872~metal ion binding, IPR001130:TatD family,IPR018228:Deoxyribonuclease, TatD-related, conserved site, Complete proteome,Hydrolase,Metal-binding,Nuclease,Nucleus,Polymorphism,Proteomics identification,Reference proteome, chain:Putative deoxyribonuclease TATDN2,modified residue,sequence variant, O17389 Tetra THymosin (four thymosin repeat protein)(tth-1) Caenorhabditis elegans GO:0007015~actin filament organization,GO:0007399~nervous system development, GO:0005829~cytosol, GO:0003785~actin monomer binding, IPR001152:Thymosin beta-4, SM00152:THY, Actin-binding,Cell junction,Complete proteome,Cytoplasm,Cytoskeleton,Reference proteome,Repeat, Q23551 Twitchin(unc-22) Caenorhabditis elegans GO:0000003~reproduction,GO:0006468~protein phosphorylation,GO:0016310~phosphorylation,GO:0018105~peptidyl-serine phosphorylation,GO:0018107~peptidyl-threonine phosphorylation,GO:0030163~protein catabolic process,GO:0040011~locomotion,GO:0040018~positive regulation of multicellular organism growth,GO:0040027~negative regulation of vulval development,GO:0051782~negative regulation of cell division, GO:0031672~A band, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005516~calmodulin binding,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0016740~transferase activity,GO:0046872~metal ion binding, IPR000719:Protein kinase, catalytic domain,IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR003961:Fibronectin, type III,IPR007110:Immunoglobulin-like domain,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR013098:Immunoglobulin I-set,IPR013783:Immunoglobulin-like fold,IPR017441:Protein kinase, ATP binding site, SM00060:FN3,SM00220:S_TKc,SM00408:IGc2,SM00409:IG, 3D-structure,Alternative splicing,ATP-binding,Calcium,Calmodulin-binding,Coiled coil,Complete proteome,Disulfide bond,Immunoglobulin domain,Kelch repeat,Kinase,Magnesium,Metal-binding,Nucleotide-binding,Proteomics identification,Reference proteome,Repeat,Serine/threonine-protein kinase,Transferase, Q6NXA9 UBX domain protein 1(ubxn1) Danio rerio GO:0031397~negative regulation of protein ubiquitination,GO:0032435~negative regulation of proteasomal ubiquitin-dependent protein catabolic process, GO:0005737~cytoplasm, GO:0071796~K6-linked polyubiquitin binding, IPR001012:UBX,IPR009060:UBA-like,IPR015940:Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote, SM00165:UBA,SM00166:UBX, Coiled coil,Complete proteome,Cytoplasm,Proteomics identification,Reference proteome, chain:UBX domain-containing protein 1,domain:UBA,domain:UBX, Q94B65 UDP-N-acetylglucosamine (UAA) transporter family(UTr7) Arabidopsis thaliana Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion, GO:0015785~UDP-galactose transport,GO:0015786~UDP-glucose transport,GO:0048527~lateral root development,GO:0080147~root hair cell development, GO:0005794~Golgi apparatus,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0005459~UDP-galactose transmembrane transporter activity,GO:0005460~UDP-glucose transmembrane transporter activity, IPR004853:Domain of unknown function DUF250, Complete proteome,Membrane,Reference proteome,Transmembrane,Transmembrane helix, Q969X6 UTP4, small subunit processome component(UTP4) Homo sapiens GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006364~rRNA processing,GO:0030490~maturation of SSU-rRNA, GO:0001650~fibrillar center,GO:0005654~nucleoplasm,GO:0005694~chromosome,GO:0005730~nucleolus,GO:0034455~t-UTP complex, GO:0005515~protein binding,GO:0044822~poly(A) RNA binding, IPR001680:WD40 repeat,IPR011047:Quinonprotein alcohol dehydrogenase-like superfamily,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR024977:Anaphase-promoting complex subunit 4, WD40 domain, hsa03008:Ribosome biogenesis in eukaryotes, 604901~Cirrhosis, North American Indian childhood type, SM00320:WD40, Alternative splicing,Chromosome,Complete proteome,Disease mutation,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,rRNA processing,Signal,Transcription,Transcription regulation,WD repeat, chain:Cirhin,repeat:WD 1,repeat:WD 10,repeat:WD 11,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,repeat:WD 8,repeat:WD 9,sequence conflict,sequence variant,splice variant, B0CM26 Uncharacterized protein C7orf63(BB_R332_JSM5F396R) Papio anubis IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold, Complete proteome,Reference proteome, Q8C190 VPS9 domain containing 1(Vps9d1) Mus musculus IPR003123:Vacuolar sorting protein 9,IPR007330:MIT, SM00167:VPS9, Alternative splicing,Complete proteome,Phosphoprotein,Proteomics identification,Reference proteome, chain:Uncharacterized protein C16orf7 homolog,domain:VPS9,splice variant, Q8N5D0 WD and tetratricopeptide repeats 1(WDTC1) Homo sapiens GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0001701~in utero embryonic development,GO:0006006~glucose metabolic process,GO:0008361~regulation of cell size,GO:0016567~protein ubiquitination,GO:0032869~cellular response to insulin stimulus,GO:0035264~multicellular organism growth,GO:0043086~negative regulation of catalytic activity,GO:0045717~negative regulation of fatty acid biosynthetic process,GO:0055082~cellular chemical homeostasis, GO:0005634~nucleus,GO:0005829~cytosol, GO:0004857~enzyme inhibitor activity,GO:0005515~protein binding,GO:0042393~histone binding,GO:0042826~histone deacetylase binding, IPR001680:WD40 repeat,IPR011990:Tetratricopeptide-like helical,IPR013026:Tetratricopeptide repeat-containing domain,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019734:Tetratricopeptide repeat, SM00028:TPR,SM00320:WD40, 3D-structure,Alternative splicing,Complete proteome,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,TPR repeat,Ubl conjugation pathway,WD repeat, chain:WD and tetratricopeptide repeats protein 1,modified residue,repeat:TPR 1,repeat:TPR 2,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,sequence conflict,splice variant, Q6VNB8 WD repeat and FYVE domain containing 3(Wdfy3) Mus musculus GO:0006914~autophagy,GO:0035973~aggrephagy, GO:0005634~nucleus,GO:0005635~nuclear envelope,GO:0005737~cytoplasm,GO:0005776~autophagosome,GO:0012505~endomembrane system,GO:0016020~membrane,GO:0016234~inclusion body,GO:0016605~PML body,GO:0019898~extrinsic component of membrane,GO:0031965~nuclear membrane,GO:0034274~Atg12-Atg5-Atg16 complex,GO:0097635~extrinsic component of autophagosome membrane, GO:0003831~beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity,GO:0005543~phospholipid binding,GO:0005545~1-phosphatidylinositol binding,GO:0016757~transferase activity, transferring glycosyl groups,GO:0046872~metal ion binding, IPR000306:Zinc finger, FYVE-type,IPR000409:BEACH domain,IPR001680:WD40 repeat,IPR011011:Zinc finger, FYVE/PHD-type,IPR011989:Armadillo-like helical,IPR011993:Pleckstrin homology-like domain,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR015943:WD40/YVTN repeat-like-containing domain,IPR016024:Armadillo-type fold,IPR017455:Zinc finger, FYVE-related,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site,IPR023362:PH-BEACH domain, SM00064:FYVE,SM00320:WD40,SM01026:SM01026, Alternative splicing,Autophagy,Complete proteome,Cytoplasm,Glycosyltransferase,Membrane,Metal-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Transferase,WD repeat,Zinc,Zinc-finger, chain:WD repeat and FYVE domain-containing protein 3,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Ser,domain:BEACH,modified residue,repeat:LRR 1,repeat:LRR 2,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,splice variant,zinc finger region:FYVE-type, O13046 WD repeat and HMG-box DNA binding protein 1 L homeolog(wdhd1.L) Xenopus laevis GO:0005654~nucleoplasm,GO:0005737~cytoplasm, GO:0003677~DNA binding, IPR001680:WD40 repeat,IPR009071:High mobility group (HMG) box domain,IPR013979:Translation initiation factor, beta propellor-like domain,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site,IPR022100:Protein of unknown function DUF3639, SM00320:WD40,SM00398:HMG, Coiled coil,Cytoplasm,DNA-binding,Nucleus,Repeat,WD repeat, Q6PAX7 WD repeat domain 1 S homeolog(wdr1.S) Xenopus laevis GO:0030043~actin filament fragmentation, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005884~actin filament,GO:0005886~plasma membrane, GO:0003779~actin binding,GO:0051015~actin filament binding, IPR001680:WD40 repeat,IPR011045:Nitrous oxide reductase, N-terminal,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site,IPR020472:G-protein beta WD-40 repeat,IPR024977:Anaphase-promoting complex subunit 4, WD40 domain, SM00320:WD40, Actin-binding,Cell membrane,Cytoplasm,Cytoskeleton,Membrane,Nucleus,Repeat,WD repeat, chain:WD repeat-containing protein 1-B,repeat:WD 1,repeat:WD 10,repeat:WD 11,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,repeat:WD 8,repeat:WD 9, Q9D994 WD repeat domain 38(Wdr38) Mus musculus GO:0002244~hematopoietic progenitor cell differentiation, IPR001680:WD40 repeat,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site,IPR020472:G-protein beta WD-40 repeat, SM00320:WD40, Complete proteome,Reference proteome,Repeat,WD repeat, chain:WD repeat-containing protein 38,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7, Q8IV35 WD repeat domain 49(WDR49) Homo sapiens GO:0005509~calcium ion binding, IPR001680:WD40 repeat,IPR002048:EF-hand domain,IPR011992:EF-hand-like domain,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site,IPR020472:G-protein beta WD-40 repeat, SM00320:WD40, Alternative splicing,Complete proteome,Polymorphism,Reference proteome,Repeat,WD repeat, chain:WD repeat-containing protein 49,modified residue,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,repeat:WD 8,sequence variant,splice variant, Q4V8C4 WD repeat domain 5B(Wdr5b) Rattus norvegicus GO:0005515~protein binding, IPR001680:WD40 repeat,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site,IPR020472:G-protein beta WD-40 repeat, SM00320:WD40, Complete proteome,Reference proteome,Repeat,Ubl conjugation pathway,WD repeat, chain:WD repeat-containing protein 5B,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,short sequence motif:DDB1-binding motif, Q562E7 WD repeat domain 81(WDR81) Homo sapiens GO:0000132~establishment of mitotic spindle orientation,GO:0007097~nuclear migration,GO:0007281~germ cell development,GO:0008090~retrograde axonal transport,GO:0010923~negative regulation of phosphatase activity,GO:0022008~neurogenesis,GO:0031023~microtubule organizing center organization,GO:0047496~vesicle transport along microtubule,GO:2000574~regulation of microtubule motor activity, GO:0000776~kinetochore,GO:0005739~mitochondrion,GO:0005813~centrosome,GO:0005874~microtubule,GO:0005875~microtubule associated complex,GO:0005938~cell cortex,GO:1904115~axon cytoplasm, GO:0008017~microtubule binding,GO:0045502~dynein binding, IPR000409:BEACH domain,IPR001680:WD40 repeat,IPR011009:Protein kinase-like domain,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain, 610185~Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 2, SM00320:WD40,SM01026:SM01026, Alternative splicing,Complete proteome,Disease mutation,Mental retardation,Mitochondrion,Polymorphism,Proteomics identification,Reference proteome,Repeat,Signal,Transit peptide,WD repeat, chain:WD repeat-containing protein 81,compositionally biased region:Glu-rich,compositionally biased region:Poly-Gly,modified residue,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,sequence conflict,sequence variant,splice variant, Q6ZQQ6 WD repeat domain 87(WDR87) Homo sapiens GO:0005737~cytoplasm, IPR001680:WD40 repeat,IPR011047:Quinonprotein alcohol dehydrogenase-like superfamily,IPR015943:WD40/YVTN repeat-like-containing domain,IPR016024:Armadillo-type fold,IPR017986:WD40-repeat-containing domain, SM00320:WD40, Alternative splicing,Coiled coil,Complete proteome,Polymorphism,Proteomics identification,Reference proteome,Repeat,WD repeat, chain:WD repeat-containing protein 87,compositionally biased region:Glu-rich,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,sequence conflict,sequence variant,splice variant, A0JP70 WD repeat domain 90(wdr90) Xenopus tropicalis General function prediction only, IPR001680:WD40 repeat,IPR007714:Protein of unknown function DUF667,IPR011044:Quinoprotein amine dehydrogenase, beta chain-like,IPR011047:Quinonprotein alcohol dehydrogenase-like superfamily,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site, SM00320:WD40, Complete proteome,Reference proteome,Repeat,WD repeat, chain:WD repeat-containing protein 90,repeat:WD 1,repeat:WD 10,repeat:WD 11,repeat:WD 12,repeat:WD 13,repeat:WD 14,repeat:WD 15,repeat:WD 16,repeat:WD 17,repeat:WD 18,repeat:WD 19,repeat:WD 2,repeat:WD 20,repeat:WD 21,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,repeat:WD 8,repeat:WD 9, Q5F457 WW domain binding protein 4(WBP4) Gallus gallus GO:0006397~mRNA processing,GO:0008380~RNA splicing,GO:0045292~mRNA cis splicing, via spliceosome, GO:0005681~spliceosomal complex,GO:0005886~plasma membrane,GO:0016607~nuclear speck, GO:0003676~nucleic acid binding,GO:0008270~zinc ion binding, IPR000690:Zinc finger, C2H2-type matrin,IPR001202:WW domain,IPR003604:Zinc finger, U1-type,IPR013085:Zinc finger, U1-C type, SM00451:ZnF_U1,SM00456:WW, Coiled coil,Complete proteome,Metal-binding,mRNA processing,mRNA splicing,Nucleus,Reference proteome,Repeat,Spliceosome,Zinc,Zinc-finger, chain:WW domain-binding protein 4,compositionally biased region:Lys-rich,domain:WW 1,domain:WW 2,zinc finger region:Matrin-type, Q5U4Q0 WW domain containing adaptor with coiled-coil(wac) Xenopus tropicalis RNA processing and modification, GO:0006351~transcription, DNA-templated,GO:0006974~cellular response to DNA damage stimulus,GO:0010390~histone monoubiquitination,GO:0044783~G1 DNA damage checkpoint,GO:0045893~positive regulation of transcription, DNA-templated,GO:0071894~histone H2B conserved C-terminal lysine ubiquitination, GO:0005634~nucleus, GO:0000993~RNA polymerase II core binding,GO:0003682~chromatin binding, IPR001202:WW domain, SM00456:WW, Chromatin regulator,Coiled coil,Complete proteome,Nucleus,Reference proteome,Transcription,Transcription regulation, Q5R9W5 WW domain containing oxidoreductase(WWOX) Pongo abelii GO:0001649~osteoblast differentiation,GO:0006915~apoptotic process,GO:0016055~Wnt signaling pathway,GO:0030178~negative regulation of Wnt signaling pathway,GO:0048705~skeletal system morphogenesis,GO:0071560~cellular response to transforming growth factor beta stimulus,GO:0072332~intrinsic apoptotic signaling pathway by p53 class mediator,GO:0097191~extrinsic apoptotic signaling pathway,GO:2001241~positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0005794~Golgi apparatus,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005902~microvillus,GO:0090575~RNA polymerase II transcription factor complex, GO:0001105~RNA polymerase II transcription coactivator activity,GO:0016491~oxidoreductase activity, IPR001202:WW domain,IPR002347:Glucose/ribitol dehydrogenase,IPR016040:NAD(P)-binding domain, SM00456:WW, Apoptosis,Complete proteome,Cytoplasm,Mitochondrion,NADP,Nucleus,Oxidoreductase,Phosphoprotein,Reference proteome,Repeat,Tumor suppressor,Ubl conjugation,Wnt signaling pathway, active site:Proton acceptor,binding site:Substrate,chain:WW domain-containing oxidoreductase,domain:WW 1,domain:WW 2,modified residue,nucleotide phosphate-binding region:NADP,region of interest:Interaction with MAPT,region of interest:Mediates targeting to the mitochondria,short sequence motif:Nuclear localization signal, Q3SZZ2 X-box binding protein 1(XBP1) Bos taurus GO:0001525~angiogenesis,GO:0001889~liver development,GO:0001935~endothelial cell proliferation,GO:0002639~positive regulation of immunoglobulin production,GO:0006351~transcription, DNA-templated,GO:0006366~transcription from RNA polymerase II promoter,GO:0006511~ubiquitin-dependent protein catabolic process,GO:0006990~positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response,GO:0007517~muscle organ development,GO:0010506~regulation of autophagy,GO:0010832~negative regulation of myotube differentiation,GO:0031017~exocrine pancreas development,GO:0031648~protein destabilization,GO:0031670~cellular response to nutrient,GO:0032869~cellular response to insulin stimulus,GO:0034976~response to endoplasmic reticulum stress,GO:0035356~cellular triglyceride homeostasis,GO:0042149~cellular response to glucose starvation,GO:0042593~glucose homeostasis,GO:0042632~cholesterol homeostasis,GO:0043066~negative regulation of apoptotic process,GO:0045348~positive regulation of MHC class II biosynthetic process,GO:0045579~positive regulation of B cell differentiation,GO:0045582~positive regulation of T cell differentiation,GO:0045600~positive regulation of fat cell differentiation,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0048666~neuron development,GO:0051024~positive regulation of immunoglobulin secretion,GO:0055089~fatty acid homeostasis,GO:0055092~sterol homeostasis,GO:0060612~adipose tissue development,GO:0060691~epithelial cell maturation involved in salivary gland development,GO:0070059~intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress,GO:0071222~cellular response to lipopolysaccharide,GO:0071230~cellular response to amino acid stimulus,GO:0071332~cellular response to fructose stimulus,GO:0071333~cellular response to glucose stimulus,GO:0071353~cellular response to interleukin-4,GO:0071375~cellular response to peptide hormone stimulus,GO:0071498~cellular response to fluid shear stress,GO:0071499~cellular response to laminar fluid shear stress,GO:1900100~positive regulation of plasma cell differentiation,GO:1900103~positive regulation of endoplasmic reticulum unfolded protein response,GO:1901800~positive regulation of proteasomal protein catabolic process,GO:1902236~negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway,GO:1903489~positive regulation of lactation,GO:1990418~response to insulin-like growth factor stimulus,GO:2000347~positive regulation of hepatocyte proliferation,GO:2000778~positive regulation of interleukin-6 secretion, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005783~endoplasmic reticulum,GO:0005789~endoplasmic reticulum membrane,GO:0016021~integral component of membrane, GO:0000977~RNA polymerase II regulatory region sequence-specific DNA binding,GO:0000981~RNA polymerase II transcription factor activity, sequence-specific DNA binding,GO:0001047~core promoter binding,GO:0001085~RNA polymerase II transcription factor binding,GO:0001158~enhancer sequence-specific DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0031490~chromatin DNA binding,GO:0046982~protein heterodimerization activity, IPR004827:Basic-leucine zipper domain, bta04141:Protein processing in endoplasmic reticulum,bta04932:Non-alcoholic fatty liver disease (NAFLD),bta05166:HTLV-I infection, SM00338:BRLZ, Acetylation,Activator,Alternative splicing,Angiogenesis,Apoptosis,Cleavage on pair of basic residues,Complete proteome,Cytoplasm,Developmental protein,Differentiation,DNA-binding,Endoplasmic reticulum,Membrane,Myogenesis,Nucleus,Phosphoprotein,Reference proteome,Signal-anchor,Stress response,Transcription,Transcription regulation,Transmembrane,Transmembrane helix,Ubl conjugation,Unfolded protein response, chain:X-box-binding protein 1,DNA-binding region:Basic motif,domain:Leucine-zipper,modified residue, P27641 X-ray repair complementing defective repair in Chinese hamster cells 5(Xrcc5) Mus musculus m_telPathway:Telomeres, Telomerase, Cellular Aging, and Immortality, GO:0000237~leptotene,GO:0000723~telomere maintenance,GO:0006281~DNA repair,GO:0006302~double-strand break repair,GO:0006303~double-strand break repair via nonhomologous end joining,GO:0006310~DNA recombination,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006974~cellular response to DNA damage stimulus,GO:0007420~brain development,GO:0008283~cell proliferation,GO:0032508~DNA duplex unwinding,GO:0042493~response to drug,GO:0045892~negative regulation of transcription, DNA-templated,GO:0048660~regulation of smooth muscle cell proliferation,GO:0050769~positive regulation of neurogenesis,GO:0060218~hematopoietic stem cell differentiation,GO:0071398~cellular response to fatty acid,GO:0071475~cellular hyperosmotic salinity response,GO:0071480~cellular response to gamma radiation,GO:0071481~cellular response to X-ray,GO:1904430~negative regulation of t-circle formation, GO:0000784~nuclear chromosome, telomeric region,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005694~chromosome,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0043234~protein complex,GO:0043564~Ku70:Ku80 complex,GO:0070419~nonhomologous end joining complex, GO:0000166~nucleotide binding,GO:0003677~DNA binding,GO:0003684~damaged DNA binding,GO:0003690~double-stranded DNA binding,GO:0003691~double-stranded telomeric DNA binding,GO:0004003~ATP-dependent DNA helicase activity,GO:0004386~helicase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008022~protein C-terminus binding,GO:0016787~hydrolase activity,GO:0016817~hydrolase activity, acting on acid anhydrides,GO:0031625~ubiquitin protein ligase binding,GO:0042162~telomeric DNA binding,GO:0044212~transcription regulatory region DNA binding,GO:0044822~poly(A) RNA binding,GO:0044877~macromolecular complex binding,GO:0051575~5'-deoxyribose-5-phosphate lyase activity, IPR002035:von Willebrand factor, type A,IPR005160:Ku70/Ku80 C-terminal arm,IPR005161:Ku70/Ku80, N-terminal alpha/beta,IPR006164:Ku70/Ku80 beta-barrel domain,IPR014893:Ku, C-terminal,IPR016194:SPOC like C-terminal domain,IPR024193:Ku80, mmu03450:Non-homologous end-joining, PIRSF016570:Ku DNA-binding complex, Ku80 subunit [Parent=PIRSF800001], SM00559:Ku78, Acetylation,Activator,ATP-binding,Chromosome,Complete proteome,DNA damage,DNA recombination,DNA repair,DNA-binding,Helicase,Hydrolase,Isopeptide bond,Nucleotide-binding,Nucleus,Phosphoprotein,Reference proteome,Signal,Transcription,Transcription regulation,Ubl conjugation, chain:ATP-dependent DNA helicase 2 subunit 2,compositionally biased region:Pro-rich,domain:Ku,domain:Leucine-zipper,modified residue,sequence conflict,short sequence motif:EEXXXDL motif, Q91YT7 YTH domain family 2(Ythdf2) Mus musculus GO:0043488~regulation of mRNA stability,GO:1903679~positive regulation of cap-independent translational initiation, GO:0000932~cytoplasmic mRNA processing body,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0003723~RNA binding,GO:0044822~poly(A) RNA binding,GO:1990247~N6-methyladenosine-containing RNA binding, IPR007275:YTH domain, Acetylation,Complete proteome,Cytoplasm,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,RNA-binding, Q9Y6Q3 ZFP37 zinc finger protein(ZFP37) Homo sapiens General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005634~nucleus, GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0008270~zinc ion binding, IPR001909:Krueppel-associated box,IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00349:KRAB,SM00355:ZnF_C2H2, Alternative splicing,Complete proteome,DNA-binding,Metal-binding,Nucleus,Phosphoprotein,Polymorphism,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 37 homolog,domain:KRAB,sequence conflict,sequence variant,splice variant,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 10,zinc finger region:C2H2-type 11,zinc finger region:C2H2-type 12,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3; atypical,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, Q49AA0 ZFP69 zinc finger protein(ZFP69) Homo sapiens General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005634~nucleus, GO:0003677~DNA binding,GO:0046872~metal ion binding, IPR001909:Krueppel-associated box,IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00349:KRAB,SM00355:ZnF_C2H2, Complete proteome,DNA-binding,Metal-binding,Nucleus,Polymorphism,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 642,domain:KRAB,domain:SCAN box,sequence conflict,sequence variant,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, Q61824 a disintegrin and metallopeptidase domain 12 (meltrin alpha)(Adam12) Mus musculus m_cardiacEGFPathway:Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, GO:0006508~proteolysis,GO:0007155~cell adhesion,GO:0007173~epidermal growth factor receptor signaling pathway, GO:0005654~nucleoplasm,GO:0005739~mitochondrion,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0004222~metalloendopeptidase activity,GO:0008233~peptidase activity,GO:0008237~metallopeptidase activity,GO:0016787~hydrolase activity,GO:0017124~SH3 domain binding,GO:0046872~metal ion binding, IPR000742:Epidermal growth factor-like domain,IPR001590:Peptidase M12B, ADAM/reprolysin,IPR001762:Blood coagulation inhibitor, Disintegrin,IPR002870:Peptidase M12B, propeptide,IPR006586:ADAM, cysteine-rich,IPR018358:Disintegrin, conserved site,IPR024079:Metallopeptidase, catalytic domain, SM00050:DISIN,SM00608:ACR, Cell adhesion,Cleavage on pair of basic residues,Complete proteome,Disulfide bond,EGF-like domain,Glycoprotein,Hydrolase,Membrane,Metal-binding,Metalloprotease,Phosphoprotein,Protease,Reference proteome,SH3-binding,Signal,Transmembrane,Transmembrane helix,Zinc,Zymogen, chain:Disintegrin and metalloproteinase domain- containing protein 12,compositionally biased region:Cys-rich,disulfide bond,domain:Disintegrin,domain:EGF-like,domain:Peptidase M12B,glycosylation site:N-linked (GlcNAc...),metal ion-binding site:Zinc; catalytic,metal ion-binding site:Zinc; in inhibited form,modified residue,short sequence motif:Cysteine switch,short sequence motif:SH3-binding; class I,short sequence motif:SH3-binding; class II,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q923W9 a disintegrin and metallopeptidase domain 33(Adam33) Mus musculus GO:0006508~proteolysis,GO:0007229~integrin-mediated signaling pathway,GO:0042035~regulation of cytokine biosynthetic process,GO:0042127~regulation of cell proliferation, GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0004222~metalloendopeptidase activity,GO:0008233~peptidase activity,GO:0008237~metallopeptidase activity,GO:0008270~zinc ion binding,GO:0016787~hydrolase activity,GO:0046872~metal ion binding, IPR000742:Epidermal growth factor-like domain,IPR001590:Peptidase M12B, ADAM/reprolysin,IPR001762:Blood coagulation inhibitor, Disintegrin,IPR002870:Peptidase M12B, propeptide,IPR006586:ADAM, cysteine-rich,IPR013032:EGF-like, conserved site,IPR018358:Disintegrin, conserved site,IPR024079:Metallopeptidase, catalytic domain, SM00050:DISIN,SM00608:ACR, Alternative splicing,Cleavage on pair of basic residues,Complete proteome,Direct protein sequencing,Disulfide bond,EGF-like domain,Glycoprotein,Hydrolase,Integrin,Membrane,Metal-binding,Metalloprotease,Protease,Reference proteome,Signal,Transmembrane,Transmembrane helix,Zinc,Zymogen, chain:Disintegrin and metalloproteinase domain- containing protein 33,compositionally biased region:Cys-rich,compositionally biased region:Poly-Pro,disulfide bond,domain:Disintegrin,domain:EGF-like,domain:Peptidase M12B,glycosylation site:N-linked (GlcNAc...),metal ion-binding site:Zinc; catalytic,metal ion-binding site:Zinc; in inhibited form,modified residue,sequence conflict,short sequence motif:Cysteine switch,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q9QZM5 abl-interactor 1(Abi1) Rattus norvegicus GO:0001756~somitogenesis,GO:0018108~peptidyl-tyrosine phosphorylation,GO:0035855~megakaryocyte development,GO:0048813~dendrite morphogenesis,GO:0061098~positive regulation of protein tyrosine kinase activity,GO:0072673~lamellipodium morphogenesis,GO:0098609~cell-cell adhesion, GO:0005622~intracellular,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005913~cell-cell adherens junction,GO:0014069~postsynaptic density,GO:0030027~lamellipodium,GO:0030054~cell junction,GO:0030175~filopodium,GO:0030426~growth cone,GO:0031209~SCAR complex,GO:0031252~cell leading edge,GO:0043005~neuron projection,GO:0045211~postsynaptic membrane,GO:0070062~extracellular exosome, GO:0005515~protein binding,GO:0008134~transcription factor binding,GO:0030296~protein tyrosine kinase activator activity,GO:0032403~protein complex binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000727:Target SNARE coiled-coil domain,IPR001452:Src homology-3 domain,IPR012849:Abl-interactor, homeo-domain homologous domain, SM00326:SH3, Acetylation,Cell junction,Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Membrane,Nucleus,Phosphoprotein,Postsynaptic cell membrane,Proteomics identification,Reference proteome,SH3 domain,Synapse, chain:Abl interactor 1,compositionally biased region:Pro-rich,domain:SH3,domain:t-SNARE coiled-coil homology,modified residue, P62289 abnormal spindle microtubule assembly(ASPM) Gorilla gorilla GO:0007051~spindle organization,GO:0007067~mitotic nuclear division,GO:0051301~cell division, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005819~spindle, IPR000048:IQ motif, EF-hand binding site,IPR001715:Calponin homology domain,IPR016024:Armadillo-type fold,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00015:IQ,SM00033:CH, Calmodulin-binding,Cell cycle,Cell division,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Mitosis,Nucleus,Phosphoprotein,Polymorphism,Reference proteome,Repeat, P21775 acetyl-CoA acyltransferase 1(Acaa1a) Rattus norvegicus GO:0000038~very long-chain fatty acid metabolic process,GO:0006635~fatty acid beta-oxidation,GO:0007584~response to nutrient,GO:0008206~bile acid metabolic process,GO:0042493~response to drug,GO:0048545~response to steroid hormone, GO:0005739~mitochondrion,GO:0005777~peroxisome,GO:0016020~membrane,GO:0043231~intracellular membrane-bounded organelle, GO:0003988~acetyl-CoA C-acyltransferase activity,GO:0008775~acetate CoA-transferase activity,GO:0016401~palmitoyl-CoA oxidase activity,GO:0016747~transferase activity, transferring acyl groups other than amino-acyl groups, IPR002155:Thiolase,IPR016039:Thiolase-like,IPR020610:Thiolase, active site,IPR020613:Thiolase, conserved site,IPR020615:Thiolase, acyl-enzyme intermediate active site,IPR020616:Thiolase, N-terminal,IPR020617:Thiolase, C-terminal, rno00071:Fatty acid degradation,rno00280:Valine, leucine and isoleucine degradation,rno00592:alpha-Linolenic acid metabolism,rno01040:Biosynthesis of unsaturated fatty acids,rno01100:Metabolic pathways,rno01130:Biosynthesis of antibiotics,rno01212:Fatty acid metabolism,rno03320:PPAR signaling pathway,rno04146:Peroxisome, PIRSF000429:acetyl-CoA acetyltransferase, Acetylation,Acyltransferase,Alternative splicing,Complete proteome,Fatty acid metabolism,Lipid metabolism,Peroxisome,Reference proteome,Transferase,Transit peptide, active site:Acyl-thioester intermediate,active site:Proton acceptor,chain:3-ketoacyl-CoA thiolase A, peroxisomal,chain:3-ketoacyl-CoA thiolase B, peroxisomal,sequence conflict,splice variant,transit peptide:Peroxisome, Q10172 actin cortical patch component, with EF hand and WH2 motif Panl (predicted)(pan1) Schizosaccharomyces pombe 972h- General function prediction only, GO:0000147~actin cortical patch assembly,GO:0006886~intracellular protein transport,GO:0006897~endocytosis, GO:0005634~nucleus,GO:0005768~endosome,GO:0005886~plasma membrane,GO:0005938~cell cortex,GO:0010008~endosome membrane,GO:0030479~actin cortical patch, GO:0003779~actin binding,GO:0005509~calcium ion binding, IPR000261:EPS15 homology (EH),IPR002048:EF-hand domain,IPR003124:WH2 domain,IPR011992:EF-hand-like domain,IPR013182:Domain of unknown function DUF1720,IPR026812:Actin cytoskeleton-regulatory complex protein Pan1, SM00027:EH,SM00246:WH2, Actin-binding,Cell membrane,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Endocytosis,Endosome,Membrane,Phosphoprotein,Reference proteome,Repeat, chain:Actin cytoskeleton-regulatory complex protein pan1,compositionally biased region:Gln-rich,compositionally biased region:Pro-rich,domain:EH 1,domain:EH 2,domain:WH2,modified residue, Q3B7N2 actinin alpha 1(ACTN1) Bos taurus GO:0030220~platelet formation,GO:0043462~regulation of ATPase activity,GO:0045214~sarcomere organization,GO:0046928~regulation of neurotransmitter secretion,GO:0048041~focal adhesion assembly,GO:0048741~skeletal muscle fiber development,GO:0051017~actin filament bundle assembly,GO:0051234~establishment of localization,GO:0051271~negative regulation of cellular component movement,GO:0051639~actin filament network formation,GO:0051764~actin crosslink formation,GO:1903506~regulation of nucleic acid-templated transcription, GO:0001725~stress fiber,GO:0001726~ruffle,GO:0005615~extracellular space,GO:0005884~actin filament,GO:0005903~brush border,GO:0005915~zonula adherens,GO:0005916~fascia adherens,GO:0005923~bicellular tight junction,GO:0005925~focal adhesion,GO:0012506~vesicle membrane,GO:0016328~lateral plasma membrane,GO:0030018~Z disc,GO:0030027~lamellipodium,GO:0030486~smooth muscle dense body,GO:0031252~cell leading edge,GO:0042383~sarcolemma,GO:0070062~extracellular exosome,GO:0090636~outer dense plaque of desmosome,GO:0090637~inner dense plaque of desmosome,GO:0097433~dense body,GO:1990357~terminal web, GO:0003725~double-stranded RNA binding,GO:0005178~integrin binding,GO:0005509~calcium ion binding,GO:0005523~tropomyosin binding,GO:0017166~vinculin binding,GO:0030374~ligand-dependent nuclear receptor transcription coactivator activity,GO:0042803~protein homodimerization activity,GO:0043495~protein anchor,GO:0044325~ion channel binding,GO:0051015~actin filament binding,GO:0051393~alpha-actinin binding, IPR001589:Actinin-type, actin-binding, conserved site,IPR001715:Calponin homology domain,IPR002017:Spectrin repeat,IPR002048:EF-hand domain,IPR011992:EF-hand-like domain,IPR014837:EF-hand, Ca insensitive,IPR018159:Spectrin/alpha-actinin,IPR018247:EF-Hand 1, calcium-binding site,IPR026921:Alpha-actinin, bta04510:Focal adhesion,bta04520:Adherens junction,bta04530:Tight junction,bta04670:Leukocyte transendothelial migration,bta04810:Regulation of actin cytoskeleton,bta05146:Amoebiasis,bta05203:Viral carcinogenesis,bta05322:Systemic lupus erythematosus, SM00033:CH,SM00054:EFh,SM00150:SPEC, Acetylation,Actin-binding,Calcium,Cell junction,Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Membrane,Metal-binding,Phosphoprotein,Reference proteome,Repeat, chain:Alpha-actinin-1,domain:Actin-binding,domain:CH 1,domain:CH 2,domain:EF-hand 1,domain:EF-hand 2,modified residue,region of interest:Interaction with DDN,repeat:Spectrin 1,repeat:Spectrin 2,repeat:Spectrin 3,repeat:Spectrin 4, P12814 actinin alpha 1(ACTN1) Homo sapiens h_cell2cellPathway:Cell to Cell Adhesion Signaling,h_integrinPathway:Integrin Signaling Pathway,h_uCalpainPathway:uCalpain and friends in Cell spread, GO:0002576~platelet degranulation,GO:0007015~actin filament organization,GO:0030168~platelet activation,GO:0030220~platelet formation,GO:0036344~platelet morphogenesis,GO:0042981~regulation of apoptotic process,GO:0048041~focal adhesion assembly,GO:0051017~actin filament bundle assembly,GO:0051271~negative regulation of cellular component movement,GO:0051639~actin filament network formation,GO:0051764~actin crosslink formation,GO:0070527~platelet aggregation,GO:1903506~regulation of nucleic acid-templated transcription, GO:0001725~stress fiber,GO:0001726~ruffle,GO:0005576~extracellular region,GO:0005615~extracellular space,GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005884~actin filament,GO:0005886~plasma membrane,GO:0005903~brush border,GO:0005911~cell-cell junction,GO:0005916~fascia adherens,GO:0005925~focal adhesion,GO:0030018~Z disc,GO:0031093~platelet alpha granule lumen,GO:0031143~pseudopodium,GO:0042995~cell projection,GO:0070062~extracellular exosome, GO:0003725~double-stranded RNA binding,GO:0005178~integrin binding,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0017166~vinculin binding,GO:0030374~ligand-dependent nuclear receptor transcription coactivator activity,GO:0042803~protein homodimerization activity,GO:0044325~ion channel binding,GO:0051015~actin filament binding, IPR001589:Actinin-type, actin-binding, conserved site,IPR001715:Calponin homology domain,IPR002017:Spectrin repeat,IPR002048:EF-hand domain,IPR011992:EF-hand-like domain,IPR014837:EF-hand, Ca insensitive,IPR018159:Spectrin/alpha-actinin,IPR018247:EF-Hand 1, calcium-binding site,IPR026921:Alpha-actinin, hsa04510:Focal adhesion,hsa04520:Adherens junction,hsa04530:Tight junction,hsa04670:Leukocyte transendothelial migration,hsa04810:Regulation of actin cytoskeleton,hsa05146:Amoebiasis,hsa05203:Viral carcinogenesis,hsa05322:Systemic lupus erythematosus, 615193~Bleeding disorder, platelet-type, 15, SM00033:CH,SM00054:EFh,SM00150:SPEC, 3D-structure,Acetylation,Actin-binding,Alternative splicing,Calcium,Cell junction,Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Disease mutation,Membrane,Metal-binding,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat, chain:Alpha-actinin-1,domain:Actin-binding,domain:CH 1,domain:CH 2,domain:EF-hand 1,domain:EF-hand 2,helix,modified residue,region of interest:Interaction with DDN,repeat:Spectrin 1,repeat:Spectrin 2,repeat:Spectrin 3,repeat:Spectrin 4,sequence conflict,sequence variant,strand,turn, F1NTD6 activating signal cointegrator 1 complex subunit 3(ASCC3) Gallus gallus General function prediction only, GO:0006307~DNA dealkylation involved in DNA repair,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0008283~cell proliferation,GO:0032508~DNA duplex unwinding, GO:0005634~nucleus,GO:0005667~transcription factor complex,GO:0005794~Golgi apparatus,GO:0016020~membrane, GO:0005524~ATP binding,GO:0043140~ATP-dependent 3'-5' DNA helicase activity,GO:0044822~poly(A) RNA binding, IPR000008:C2 calcium-dependent membrane targeting,IPR001650:Helicase, C-terminal,IPR003593:AAA+ ATPase domain,IPR004179:Sec63 domain,IPR011545:DNA/RNA helicase, DEAD/DEAH box type, N-terminal,IPR011991:Winged helix-turn-helix DNA-binding domain,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR014756:Immunoglobulin E-set,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00382:AAA,SM00487:DEXDc,SM00490:HELICc,SM00973:SM00973, ATP-binding,Complete proteome,DNA damage,DNA repair,Helicase,Hydrolase,Nucleotide-binding,Nucleus,Reference proteome,Repeat,Transcription,Transcription regulation, Q9GPH3 activating transcription factor(Atf) Bombyx mori GO:0006351~transcription, DNA-templated,GO:0006986~response to unfolded protein, GO:0005634~nucleus, GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0043565~sequence-specific DNA binding, IPR004827:Basic-leucine zipper domain, SM00338:BRLZ, Activator,Complete proteome,DNA-binding,Nucleus,Reference proteome,Transcription,Transcription regulation,Unfolded protein response, chain:Activating transcription factor of chaperone,DNA-binding region:Basic motif,domain:Leucine-zipper, Q8JZN5 acyl-Coenzyme A dehydrogenase family, member 9(Acad9) Mus musculus Lipid metabolism, GO:0008152~metabolic process,GO:0032981~mitochondrial respiratory chain complex I assembly,GO:0033539~fatty acid beta-oxidation using acyl-CoA dehydrogenase,GO:0055088~lipid homeostasis,GO:0055114~oxidation-reduction process, GO:0005634~nucleus,GO:0005739~mitochondrion,GO:0030425~dendrite, GO:0000062~fatty-acyl-CoA binding,GO:0003995~acyl-CoA dehydrogenase activity,GO:0009055~electron carrier activity,GO:0016491~oxidoreductase activity,GO:0016627~oxidoreductase activity, acting on the CH-CH group of donors,GO:0050660~flavin adenine dinucleotide binding,GO:0052890~oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor, IPR006089:Acyl-CoA dehydrogenase, conserved site,IPR006091:Acyl-CoA oxidase/dehydrogenase, central domain,IPR009075:Acyl-CoA dehydrogenase/oxidase C-terminal,IPR009100:Acyl-CoA dehydrogenase/oxidase,IPR013786:Acyl-CoA dehydrogenase/oxidase, N-terminal, Acetylation,Complete proteome,FAD,Flavoprotein,Mitochondrion,Oxidoreductase,Phosphoprotein,Proteomics identification,Reference proteome,Transit peptide, active site:Proton acceptor,chain:Acyl-CoA dehydrogenase family member 9, mitochondrial,modified residue,sequence conflict,transit peptide:Mitochondrion, Q5FVR5 acyl-coenzyme A amino acid N-acyltransferase 2(Acnat2) Rattus norvegicus GO:0006631~fatty acid metabolic process,GO:0006637~acyl-CoA metabolic process, GO:0005777~peroxisome, GO:0016410~N-acyltransferase activity,GO:0016790~thiolester hydrolase activity, IPR006862:Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase,IPR014940:BAAT/Acyl-CoA thioester hydrolase C-terminal,IPR016662:Acyl-CoA thioesterase, long chain, PIRSF016521:acyl-CoA thioesterase (hydrolase), Acyltransferase,Complete proteome,Fatty acid metabolism,Lipid metabolism,Peroxisome,Proteomics identification,Reference proteome,Transferase, active site:Charge relay system,chain:Acyl-coenzyme A amino acid N- acyltransferase 2,short sequence motif:Microbody targeting signal, Q8R146 acylpeptide hydrolase(Apeh) Mus musculus Amino acid transport and metabolism, GO:0006508~proteolysis,GO:0050435~beta-amyloid metabolic process, GO:0005737~cytoplasm,GO:0031965~nuclear membrane,GO:0070062~extracellular exosome, GO:0004252~serine-type endopeptidase activity,GO:0008236~serine-type peptidase activity,GO:0008242~omega peptidase activity,GO:0016787~hydrolase activity,GO:0044822~poly(A) RNA binding, IPR001375:Peptidase S9, prolyl oligopeptidase, catalytic domain,IPR002471:Peptidase S9, serine active site,IPR015943:WD40/YVTN repeat-like-containing domain, Acetylation,Alternative splicing,Complete proteome,Cytoplasm,Hydrolase,Phosphoprotein,Proteomics identification,Reference proteome, active site:Charge relay system,chain:Acylamino-acid-releasing enzyme,modified residue,splice variant, Q9UKG1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1(APPL1) Homo sapiens Signal transduction mechanisms, GO:0007049~cell cycle,GO:0007165~signal transduction,GO:0008283~cell proliferation,GO:0008286~insulin receptor signaling pathway,GO:0046324~regulation of glucose import,GO:0090003~regulation of establishment of protein localization to plasma membrane,GO:0097192~extrinsic apoptotic signaling pathway in absence of ligand, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0010008~endosome membrane,GO:0012506~vesicle membrane,GO:0016581~NuRD complex,GO:0031901~early endosome membrane,GO:0070062~extracellular exosome, GO:0005515~protein binding,GO:0042802~identical protein binding,GO:0043422~protein kinase B binding, IPR001849:Pleckstrin homology domain,IPR006020:Phosphotyrosine interaction domain,IPR011993:Pleckstrin homology-like domain,IPR027267:Arfaptin homology (AH) domain/BAR domain, hsa05200:Pathways in cancer,hsa05210:Colorectal cancer, 616511~Maturity-onset diabetes of the young, type 14, SM00233:PH,SM00462:PTB, 3D-structure,Cell cycle,Coiled coil,Complete proteome,Diabetes mellitus,Disease mutation,Endosome,Membrane,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:DCC-interacting protein 13-alpha,domain:PH,domain:PID,helix,modified residue,region of interest:Required for RAB5A binding,sequence variant,strand,turn, Q8NEU8 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2(APPL2) Homo sapiens GO:0007049~cell cycle,GO:0007165~signal transduction,GO:0008283~cell proliferation, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0010008~endosome membrane,GO:0016581~NuRD complex,GO:0031901~early endosome membrane,GO:0070062~extracellular exosome, GO:0005515~protein binding, IPR001849:Pleckstrin homology domain,IPR006020:Phosphotyrosine interaction domain,IPR011993:Pleckstrin homology-like domain, SM00233:PH,SM00462:PTB, 3D-structure,Alternative splicing,Cell cycle,Chromosomal rearrangement,Complete proteome,Endosome,Membrane,Nucleus,Polymorphism,Proteomics identification,Reference proteome, chain:DCC-interacting protein 13-beta,domain:PH,domain:PID,region of interest:Required for RAB5A binding,sequence conflict,sequence variant,site:Breakpoint for chromosomal translocation, Q8K3H0 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1(Appl1) Mus musculus GO:0007049~cell cycle,GO:0008283~cell proliferation,GO:0008286~insulin receptor signaling pathway,GO:0046324~regulation of glucose import,GO:0090003~regulation of establishment of protein localization to plasma membrane, GO:0005634~nucleus,GO:0005768~endosome,GO:0005829~cytosol,GO:0010008~endosome membrane,GO:0012506~vesicle membrane,GO:0016020~membrane,GO:0016581~NuRD complex,GO:0031901~early endosome membrane,GO:0070062~extracellular exosome, GO:0042802~identical protein binding,GO:0043422~protein kinase B binding, IPR001849:Pleckstrin homology domain,IPR006020:Phosphotyrosine interaction domain,IPR011993:Pleckstrin homology-like domain,IPR027267:Arfaptin homology (AH) domain/BAR domain, mmu05200:Pathways in cancer,mmu05210:Colorectal cancer, SM00233:PH,SM00462:PTB, Cell cycle,Coiled coil,Complete proteome,Endosome,Membrane,Nucleus,Phosphoprotein,Reference proteome, chain:DCC-interacting protein 13-alpha,domain:PH,domain:PID,modified residue,region of interest:Required for RAB5A binding,sequence conflict, Q0VCK5 adaptor related protein complex 2 alpha 2 subunit(AP2A2) Bos taurus GO:0006886~intracellular protein transport,GO:0006897~endocytosis,GO:0016192~vesicle-mediated transport,GO:0048268~clathrin coat assembly, GO:0016023~cytoplasmic, membrane-bounded vesicle,GO:0030122~AP-2 adaptor complex,GO:0030131~clathrin adaptor complex, GO:0005515~protein binding,GO:0008289~lipid binding,GO:0008565~protein transporter activity, IPR002553:Clathrin/coatomer adaptor, adaptin-like, N-terminal,IPR003164:Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain,IPR008152:Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain,IPR009028:Coatomer/calthrin adaptor appendage, C-terminal subdomain,IPR011989:Armadillo-like helical,IPR013038:Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain,IPR013041:Coatomer/clathrin adaptor appendage, Ig-like subdomain,IPR015873:Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain,IPR016024:Armadillo-type fold,IPR017104:Adaptor protein complex AP-2, alpha subunit, bta04144:Endocytosis,bta04721:Synaptic vesicle cycle,bta04961:Endocrine and other factor-regulated calcium reabsorption,bta05016:Huntington's disease, PIRSF037091:adaptor protein complex AP-2, alpha subunit, SM00809:Alpha_adaptinC2, Cell membrane,Coated pit,Complete proteome,Direct protein sequencing,Endocytosis,Lipid-binding,Membrane,Protein transport,Reference proteome,Transport, binding site:Phosphatidylinositol lipid headgroup,chain:AP-2 complex subunit alpha-2,modified residue,region of interest:Lipid-binding, Q61315 adenomatosis polyposis coli(Apc) Mus musculus M_gsk3Pathway:Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages,m_pitx2Pathway:Multi-step Regulation of Transcription by Pitx2,m_ps1Pathway:Presenilin action in Notch and Wnt signaling,m_tgfbPathway:TGF beta signaling pathway,m_wntPathway:WNT Signaling Pathway, GO:0000281~mitotic cytokinesis,GO:0001708~cell fate specification,GO:0001822~kidney development,GO:0001942~hair follicle development,GO:0006461~protein complex assembly,GO:0006974~cellular response to DNA damage stimulus,GO:0007026~negative regulation of microtubule depolymerization,GO:0007050~cell cycle arrest,GO:0007091~metaphase/anaphase transition of mitotic cell cycle,GO:0007094~mitotic spindle assembly checkpoint,GO:0007163~establishment or maintenance of cell polarity,GO:0007389~pattern specification process,GO:0007409~axonogenesis,GO:0008285~negative regulation of cell proliferation,GO:0009798~axis specification,GO:0009952~anterior/posterior pattern specification,GO:0009953~dorsal/ventral pattern formation,GO:0009954~proximal/distal pattern formation,GO:0016055~Wnt signaling pathway,GO:0016477~cell migration,GO:0019827~stem cell population maintenance,GO:0030178~negative regulation of Wnt signaling pathway,GO:0030334~regulation of cell migration,GO:0030335~positive regulation of cell migration,GO:0030856~regulation of epithelial cell differentiation,GO:0030858~positive regulation of epithelial cell differentiation,GO:0031116~positive regulation of microtubule polymerization,GO:0031122~cytoplasmic microtubule organization,GO:0031175~neuron projection development,GO:0031274~positive regulation of pseudopodium assembly,GO:0032886~regulation of microtubule-based process,GO:0033077~T cell differentiation in thymus,GO:0035019~somatic stem cell population maintenance,GO:0042483~negative regulation of odontogenesis,GO:0043065~positive regulation of apoptotic process,GO:0043066~negative regulation of apoptotic process,GO:0043409~negative regulation of MAPK cascade,GO:0043588~skin development,GO:0044336~canonical Wnt signaling pathway involved in negative regulation of apoptotic process,GO:0044337~canonical Wnt signaling pathway involved in positive regulation of apoptotic process,GO:0045595~regulation of cell differentiation,GO:0045597~positive regulation of cell differentiation,GO:0045667~regulation of osteoblast differentiation,GO:0045670~regulation of osteoclast differentiation,GO:0045732~positive regulation of protein catabolic process,GO:0045736~negative regulation of cyclin-dependent protein serine/threonine kinase activity,GO:0045785~positive regulation of cell adhesion,GO:0046716~muscle cell cellular homeostasis,GO:0048538~thymus development,GO:0050680~negative regulation of epithelial cell proliferation,GO:0051171~regulation of nitrogen compound metabolic process,GO:0051276~chromosome organization,GO:0051726~regulation of cell cycle,GO:0051781~positive regulation of cell division,GO:0051988~regulation of attachment of spindle microtubules to kinetochore,GO:0060041~retina development in camera-type eye,GO:0060070~canonical Wnt signaling pathway,GO:0060770~negative regulation of epithelial cell proliferation involved in prostate gland development,GO:0090090~negative regulation of canonical Wnt signaling pathway,GO:2000211~regulation of glutamate metabolic process, GO:0000776~kinetochore,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005856~cytoskeleton,GO:0005874~microtubule,GO:0005881~cytoplasmic microtubule,GO:0005886~plasma membrane,GO:0005912~adherens junction,GO:0005913~cell-cell adherens junction,GO:0005923~bicellular tight junction,GO:0005938~cell cortex,GO:0016020~membrane,GO:0016328~lateral plasma membrane,GO:0016342~catenin complex,GO:0030027~lamellipodium,GO:0030054~cell junction,GO:0030424~axon,GO:0030425~dendrite,GO:0030426~growth cone,GO:0030877~beta-catenin destruction complex,GO:0031253~cell projection membrane,GO:0031965~nuclear membrane,GO:0032587~ruffle membrane,GO:0034750~Scrib-APC-beta-catenin complex,GO:0035371~microtubule plus-end,GO:0042995~cell projection,GO:0043005~neuron projection,GO:0043025~neuronal cell body,GO:0043234~protein complex,GO:0044295~axonal growth cone,GO:0044306~neuron projection terminus,GO:0045202~synapse,GO:0048471~perinuclear region of cytoplasm,GO:0070852~cell body fiber, GO:0002020~protease binding,GO:0005515~protein binding,GO:0008013~beta-catenin binding,GO:0008017~microtubule binding,GO:0019887~protein kinase regulator activity,GO:0019901~protein kinase binding,GO:0031625~ubiquitin protein ligase binding,GO:0032403~protein complex binding,GO:0045295~gamma-catenin binding,GO:0051010~microtubule plus-end binding, IPR000225:Armadillo,IPR009223:Adenomatous polyposis coli protein, cysteine-rich repeat,IPR009224:SAMP,IPR009232:EB-1 binding,IPR009234:Adenomatous polyposis coli protein basic domain,IPR009240:Adenomatous polyposis coli protein, 15 residue repeat,IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold,IPR026818:Adenomatous polyposis coli (APC) family,IPR026831:Adenomatous polyposis coli domain,IPR026836:Adenomatous polyposis coli, mmu04310:Wnt signaling pathway,mmu04390:Hippo signaling pathway,mmu04550:Signaling pathways regulating pluripotency of stem cells,mmu04810:Regulation of actin cytoskeleton,mmu05166:HTLV-I infection,mmu05200:Pathways in cancer,mmu05206:MicroRNAs in cancer,mmu05210:Colorectal cancer,mmu05213:Endometrial cancer,mmu05217:Basal cell carcinoma, SM00185:ARM, 3D-structure,Acetylation,Alternative splicing,Cell junction,Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Membrane,Microtubule,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Tumor suppressor,Ubl conjugation,Wnt signaling pathway, chain:Adenomatous polyposis coli protein,compositionally biased region:Asp/Glu-rich (acidic),compositionally biased region:Leu-rich,compositionally biased region:Ser-rich,modified residue,region of interest:Highly charged,repeat:ARM 1,repeat:ARM 2,repeat:ARM 3,repeat:ARM 4,repeat:ARM 5,repeat:ARM 6,repeat:ARM 7,sequence variant,short sequence motif:PDZ-binding,splice variant, Q91ZS8 adenosine deaminase, RNA-specific, B1(Adarb1) Mus musculus GO:0006382~adenosine to inosine editing,GO:0006396~RNA processing,GO:0006397~mRNA processing,GO:0008285~negative regulation of cell proliferation,GO:0016553~base conversion or substitution editing,GO:0016556~mRNA modification,GO:0030336~negative regulation of cell migration,GO:0044387~negative regulation of protein kinase activity by regulation of protein phosphorylation,GO:0045070~positive regulation of viral genome replication,GO:0050685~positive regulation of mRNA processing,GO:0051726~regulation of cell cycle, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0016021~integral component of membrane, GO:0003723~RNA binding,GO:0003725~double-stranded RNA binding,GO:0003726~double-stranded RNA adenosine deaminase activity,GO:0004000~adenosine deaminase activity,GO:0016787~hydrolase activity,GO:0042803~protein homodimerization activity,GO:0044822~poly(A) RNA binding,GO:0046872~metal ion binding, IPR002466:Adenosine deaminase/editase,IPR014720:Double-stranded RNA-binding-like domain, SM00358:DSRM,SM00552:ADEAMc, 3D-structure,Alternative splicing,Complete proteome,Hydrolase,Membrane,Metal-binding,mRNA processing,Nucleus,Phosphoprotein,Reference proteome,Repeat,RNA-binding,Transmembrane,Transmembrane helix,Zinc, active site:Proton donor,binding site:Inositol hexakisphosphate,chain:Double-stranded RNA-specific editase 1,domain:A to I editase,domain:DRBM 1,domain:DRBM 2,metal ion-binding site:Zinc,sequence conflict,splice variant, Q08462 adenylate cyclase 2(ADCY2) Homo sapiens GO:0003091~renal water homeostasis,GO:0006171~cAMP biosynthetic process,GO:0007188~adenylate cyclase-modulating G-protein coupled receptor signaling pathway,GO:0007189~adenylate cyclase-activating G-protein coupled receptor signaling pathway,GO:0007190~activation of adenylate cyclase activity,GO:0007193~adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway,GO:0009190~cyclic nucleotide biosynthetic process,GO:0019933~cAMP-mediated signaling,GO:0034199~activation of protein kinase A activity,GO:0035556~intracellular signal transduction,GO:0071377~cellular response to glucagon stimulus,GO:1904322~cellular response to forskolin, GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030425~dendrite,GO:0045121~membrane raft, GO:0000166~nucleotide binding,GO:0000287~magnesium ion binding,GO:0004016~adenylate cyclase activity,GO:0005524~ATP binding,GO:0008179~adenylate cyclase binding,GO:0016849~phosphorus-oxygen lyase activity,GO:0030145~manganese ion binding,GO:0046982~protein heterodimerization activity, IPR001054:Adenylyl cyclase class-3/4/guanylyl cyclase,IPR009398:Adenylate cyclase-like,IPR018297:Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site, hsa00230:Purine metabolism,hsa04015:Rap1 signaling pathway,hsa04020:Calcium signaling pathway,hsa04022:cGMP-PKG signaling pathway,hsa04024:cAMP signaling pathway,hsa04062:Chemokine signaling pathway,hsa04114:Oocyte meiosis,hsa04261:Adrenergic signaling in cardiomyocytes,hsa04270:Vascular smooth muscle contraction,hsa04540:Gap junction,hsa04611:Platelet activation,hsa04713:Circadian entrainment,hsa04723:Retrograde endocannabinoid signaling,hsa04724:Glutamatergic synapse,hsa04725:Cholinergic synapse,hsa04727:GABAergic synapse,hsa04750:Inflammatory mediator regulation of TRP channels,hsa04911:Insulin secretion,hsa04912:GnRH signaling pathway,hsa04913:Ovarian steroidogenesis,hsa04914:Progesterone-mediated oocyte maturation,hsa04915:Estrogen signaling pathway,hsa04916:Melanogenesis,hsa04918:Thyroid hormone synthesis,hsa04921:Oxytocin signaling pathway,hsa04922:Glucagon signaling pathway,hsa04923:Regulation of lipolysis in adipocytes,hsa04925:Aldosterone synthesis and secretion,hsa04970:Salivary secretion,hsa04971:Gastric acid secretion,hsa04972:Pancreatic secretion,hsa04976:Bile secretion,hsa05032:Morphine addiction,hsa05166:HTLV-I infection,hsa05200:Pathways in cancer,hsa05414:Dilated cardiomyopathy, SM00044:CYCc, Alternative splicing,ATP-binding,cAMP biosynthesis,Cell membrane,Complete proteome,Cytoplasm,Glycoprotein,Lyase,Magnesium,Manganese,Membrane,Metal-binding,Nucleotide-binding,Phosphoprotein,Polymorphism,Reference proteome,Repeat,Transmembrane,Transmembrane helix, chain:Adenylate cyclase type 2,glycosylation site:N-linked (GlcNAc...),metal ion-binding site:Magnesium 1,metal ion-binding site:Magnesium 2,metal ion-binding site:Magnesium 2; via carbonyl oxygen,sequence conflict,sequence variant,topological domain:Cytoplasmic,transmembrane region, Q8VHN7 adhesion G protein-coupled receptor V1(Adgrv1) Mus musculus GO:0007154~cell communication,GO:0007165~signal transduction,GO:0007166~cell surface receptor signaling pathway,GO:0007186~G-protein coupled receptor signaling pathway,GO:0007275~multicellular organism development,GO:0007399~nervous system development,GO:0007601~visual perception,GO:0007605~sensory perception of sound,GO:0010739~positive regulation of protein kinase A signaling,GO:0016337~single organismal cell-cell adhesion,GO:0045184~establishment of protein localization,GO:0045494~photoreceptor cell maintenance,GO:0048496~maintenance of organ identity,GO:0048839~inner ear development,GO:0050877~neurological system process,GO:0050896~response to stimulus,GO:0050910~detection of mechanical stimulus involved in sensory perception of sound,GO:0050953~sensory perception of light stimulus,GO:0060122~inner ear receptor stereocilium organization,GO:0071277~cellular response to calcium ion, GO:0002141~stereocilia ankle link,GO:0002142~stereocilia ankle link complex,GO:0005576~extracellular region,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0009986~cell surface,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0032391~photoreceptor connecting cilium,GO:0032420~stereocilium,GO:0043235~receptor complex,GO:0045202~synapse,GO:0048471~perinuclear region of cytoplasm,GO:0070062~extracellular exosome,GO:1990075~periciliary membrane compartment,GO:1990696~USH2 complex, GO:0004871~signal transducer activity,GO:0004888~transmembrane signaling receptor activity,GO:0004930~G-protein coupled receptor activity,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0017022~myosin binding, IPR000203:GPS domain,IPR000832:GPCR, family 2, secretin-like,IPR003644:Na-Ca exchanger/integrin-beta4,IPR005492:Leucine-rich glioma-inactivated , EPTP repeat,IPR006558:LamG-like jellyroll fold,IPR009039:EAR,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR017981:GPCR, family 2-like,IPR026919:G protein-coupled receptor 98, SM00237:Calx_beta,SM00560:LamGL, Alternative splicing,Calcium,Cell membrane,Complete proteome,Developmental protein,G-protein coupled receptor,Membrane,Receptor,Reference proteome,Repeat,Secreted,Sensory transduction,Signal,Transducer,Transmembrane,Transmembrane helix, chain:G-protein coupled receptor 98,domain:Calx-beta 1,domain:Calx-beta 10,domain:Calx-beta 11,domain:Calx-beta 12,domain:Calx-beta 13,domain:Calx-beta 14,domain:Calx-beta 15,domain:Calx-beta 16,domain:Calx-beta 17,domain:Calx-beta 18,domain:Calx-beta 19,domain:Calx-beta 2,domain:Calx-beta 20,domain:Calx-beta 21,domain:Calx-beta 22,domain:Calx-beta 23,domain:Calx-beta 24,domain:Calx-beta 25,domain:Calx-beta 26,domain:Calx-beta 27,domain:Calx-beta 28,domain:Calx-beta 29,domain:Calx-beta 3,domain:Calx-beta 31,domain:Calx-beta 32,domain:Calx-beta 33,domain:Calx-beta 34,domain:Calx-beta 35,domain:Calx-beta 4,domain:Calx-beta 5,domain:Calx-beta 6,domain:Calx-beta 7,domain:Calx-beta 8,domain:Calx-beta 9,domain:GPS,repeat:EAR 1,repeat:EAR 2,repeat:EAR 3,repeat:EAR 4,repeat:EAR 5,repeat:EAR 6,sequence conflict,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q5ZIF1 adipocyte plasma membrane associated protein(APMAP) Gallus gallus Carbohydrate transport and metabolism, GO:0009058~biosynthetic process, GO:0005783~endoplasmic reticulum,GO:0009986~cell surface,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0070062~extracellular exosome, GO:0004064~arylesterase activity,GO:0016788~hydrolase activity, acting on ester bonds,GO:0016844~strictosidine synthase activity, IPR011042:Six-bladed beta-propeller, TolB-like,IPR018119:Strictosidine synthase, conserved region, Complete proteome,Glycoprotein,Membrane,Reference proteome,Signal-anchor,Transmembrane,Transmembrane helix, chain:Adipocyte plasma membrane-associated protein,glycosylation site:N-linked (GlcNAc...),topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, P55196 afadin, adherens junction formation factor(AFDN) Homo sapiens GO:0007155~cell adhesion,GO:0007165~signal transduction,GO:0007267~cell-cell signaling,GO:0021987~cerebral cortex development,GO:0032880~regulation of protein localization,GO:0034332~adherens junction organization,GO:0034334~adherens junction maintenance,GO:0043547~positive regulation of GTPase activity,GO:0048854~brain morphogenesis,GO:0048872~homeostasis of number of cells,GO:0060019~radial glial cell differentiation,GO:0060563~neuroepithelial cell differentiation,GO:0070445~regulation of oligodendrocyte progenitor proliferation,GO:0090557~establishment of endothelial intestinal barrier,GO:0098609~cell-cell adhesion, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005911~cell-cell junction,GO:0005913~cell-cell adherens junction,GO:0030054~cell junction,GO:0045177~apical part of cell, GO:0005515~protein binding,GO:0008022~protein C-terminus binding,GO:0017016~Ras GTPase binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000159:Ras-association,IPR000253:Forkhead-associated (FHA) domain,IPR001478:PDZ domain,IPR002710:Dilute,IPR008984:SMAD/FHA domain, hsa04014:Ras signaling pathway,hsa04015:Rap1 signaling pathway,hsa04024:cAMP signaling pathway,hsa04520:Adherens junction,hsa04530:Tight junction,hsa04670:Leukocyte transendothelial migration, SM00228:PDZ,SM00240:FHA,SM00314:RA,SM01132:SM01132, 3D-structure,Acetylation,Alternative splicing,Cell adhesion,Cell junction,Chromosomal rearrangement,Coiled coil,Complete proteome,Phosphoprotein,Proteomics identification,Proto-oncogene,Reference proteome,Repeat, chain:Afadin,compositionally biased region:Asp/Glu-rich (acidic),compositionally biased region:Glu/Lys-rich,compositionally biased region:Pro-rich,domain:Dilute,domain:FHA,domain:PDZ,domain:Ras-associating 1,domain:Ras-associating 2,helix,modified residue,sequence conflict,site:Breakpoint for translocation to form MLL- MLLT4,splice variant,strand, P79098 alanyl aminopeptidase, membrane(ANPEP) Bos taurus Amino acid transport and metabolism, GO:0001525~angiogenesis,GO:0006508~proteolysis,GO:0030154~cell differentiation,GO:0043171~peptide catabolic process,GO:0046718~viral entry into host cell, GO:0005615~extracellular space,GO:0005737~cytoplasm,GO:0005765~lysosomal membrane,GO:0005793~endoplasmic reticulum-Golgi intermediate compartment,GO:0005886~plasma membrane,GO:0009897~external side of plasma membrane,GO:0016021~integral component of membrane,GO:0070062~extracellular exosome, GO:0001618~virus receptor activity,GO:0008237~metallopeptidase activity,GO:0008270~zinc ion binding,GO:0042277~peptide binding,GO:0070006~metalloaminopeptidase activity, IPR001930:Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase,IPR014782:Peptidase M1, membrane alanine aminopeptidase, N-terminal,IPR024571:Domain of unknown function DUF3358, bta00480:Glutathione metabolism,bta01100:Metabolic pathways,bta04614:Renin-angiotensin system,bta04640:Hematopoietic cell lineage, Aminopeptidase,Angiogenesis,Complete proteome,Developmental protein,Differentiation,Disulfide bond,Glycoprotein,Host cell receptor for virus entry,Hydrolase,Membrane,Metal-binding,Metalloprotease,Protease,Receptor,Reference proteome,Signal-anchor,Sulfation,Transmembrane,Transmembrane helix,Zinc, active site:Proton donor,chain:Aminopeptidase N,glycosylation site:N-linked (GlcNAc...),metal ion-binding site:Zinc; catalytic,modified residue,region of interest:Cytosolic Ser/Thr-rich junction,region of interest:Metalloprotease,topological domain:Cytoplasmic,transmembrane region, Q5RC02 alanyl-tRNA synthetase(AARS) Pongo abelii GO:0001942~hair follicle development,GO:0006400~tRNA modification,GO:0006419~alanyl-tRNA aminoacylation,GO:0006457~protein folding,GO:0021680~cerebellar Purkinje cell layer development,GO:0030968~endoplasmic reticulum unfolded protein response,GO:0043200~response to amino acid,GO:0043524~negative regulation of neuron apoptotic process,GO:0050885~neuromuscular process controlling balance, GO:0005737~cytoplasm,GO:0016020~membrane,GO:0070062~extracellular exosome, GO:0000049~tRNA binding,GO:0002161~aminoacyl-tRNA editing activity,GO:0004813~alanine-tRNA ligase activity,GO:0005524~ATP binding,GO:0008270~zinc ion binding, IPR002318:Alanine-tRNA ligase, class IIc,IPR003156:Phosphoesterase, DHHA1,IPR009000:Translation elongation/initiation factor/Ribosomal, beta-barrel,IPR012947:Threonyl/alanyl tRNA synthetase, SAD,IPR018162:Alanine-tRNA ligase, class IIc, anti-codon-binding domain,IPR018163:Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain,IPR018164:Alanyl-tRNA synthetase, class IIc, N-terminal,IPR018165:Alanyl-tRNA synthetase, class IIc, core domain,IPR023033:Alanine-tRNA ligase, eukaryota/bacteria, pon00970:Aminoacyl-tRNA biosynthesis, SM00863:SM00863, Acetylation,Aminoacyl-tRNA synthetase,ATP-binding,Complete proteome,Cytoplasm,Ligase,Metal-binding,Nucleotide-binding,Phosphoprotein,Protein biosynthesis,Reference proteome,RNA-binding,tRNA-binding,Ubl conjugation,Zinc, chain:Alanyl-tRNA synthetase, cytoplasmic,modified residue,region of interest:Catalytic, Q6GNL7 aldehyde dehydrogenase 1 family member L1 L homeolog(aldh1l1.L) Xenopus laevis Translation, ribosomal structure and biogenesis, GO:0006730~one-carbon metabolic process,GO:0009058~biosynthetic process,GO:0009258~10-formyltetrahydrofolate catabolic process, GO:0005737~cytoplasm, GO:0016155~formyltetrahydrofolate dehydrogenase activity,GO:0016620~oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor,GO:0016742~hydroxymethyl-, formyl- and related transferase activity, IPR001555:Phosphoribosylglycinamide formyltransferase, active site,IPR002376:Formyl transferase, N-terminal,IPR005793:Formyl transferase, C-terminal,IPR009081:Acyl carrier protein-like,IPR011034:Formyl transferase, C-terminal-like,IPR011407:10-formyltetrahydrofolate dehydrogenase,IPR015590:Aldehyde dehydrogenase domain,IPR016160:Aldehyde dehydrogenase, conserved site,IPR016161:Aldehyde/histidinol dehydrogenase,IPR016162:Aldehyde dehydrogenase, N-terminal,IPR016163:Aldehyde dehydrogenase, C-terminal, xla00670:One carbon pool by folate, PIRSF036489:10-formyltetrahydrofolate dehydrogenase, Cytoplasm,NADP,One-carbon metabolism,Oxidoreductase,Phosphopantetheine,Phosphoprotein, active site:Proton donor,chain:10-formyltetrahydrofolate dehydrogenase,domain:Acyl carrier,modified residue,region of interest:Aldehyde dehydrogenase,region of interest:GART,site:Essential for catalytic activity, A6QR56 aldehyde dehydrogenase 16 family member A1(ALDH16A1) Bos taurus GO:0055114~oxidation-reduction process, GO:0016020~membrane,GO:0070062~extracellular exosome, GO:0016620~oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor,GO:0019145~aminobutyraldehyde dehydrogenase activity,GO:0047105~4-trimethylammoniobutyraldehyde dehydrogenase activity, IPR011408:Aldehyde dehydrogenase,IPR015590:Aldehyde dehydrogenase domain,IPR016161:Aldehyde/histidinol dehydrogenase,IPR016162:Aldehyde dehydrogenase, N-terminal,IPR016163:Aldehyde dehydrogenase, C-terminal, PIRSF036490:aldehyde dehydrogenase with duplicated domain, Complete proteome,Proteomics identification,Reference proteome, chain:Aldehyde dehydrogenase family 16 member A1,modified residue, P37111 aminoacylase 1(ACY1) Sus scrofa Amino acid transport and metabolism, GO:0006508~proteolysis,GO:0006520~cellular amino acid metabolic process,GO:0043171~peptide catabolic process, GO:0005737~cytoplasm, GO:0004046~aminoacylase activity,GO:0008270~zinc ion binding,GO:0070573~metallodipeptidase activity, IPR001261:ArgE/DapE/ACY1/CPG2/YscS, conserved site,IPR002933:Peptidase M20,IPR010159:N-acyl-L-amino-acid amidohydrolase,IPR011650:Peptidase M20, dimerisation domain, ssc00220:Arginine biosynthesis,ssc01100:Metabolic pathways,ssc01130:Biosynthesis of antibiotics,ssc01210:2-Oxocarboxylic acid metabolism,ssc01230:Biosynthesis of amino acids, PIRSF036696:acyl-amino-acid amidohydrolase 1, Acetylation,Complete proteome,Cytoplasm,Direct protein sequencing,Hydrolase,Metal-binding,Reference proteome,Zinc, active site:Proton acceptor,chain:Aminoacylase-1,metal ion-binding site:Zinc 1,metal ion-binding site:Zinc 2,modified residue,sequence conflict, Q6AYS7 aminoacylase 1(Acy1) Rattus norvegicus Amino acid transport and metabolism, GO:0006508~proteolysis,GO:0006520~cellular amino acid metabolic process,GO:0030163~protein catabolic process,GO:0043171~peptide catabolic process, GO:0005737~cytoplasm, GO:0004046~aminoacylase activity,GO:0008237~metallopeptidase activity,GO:0008270~zinc ion binding,GO:0046872~metal ion binding,GO:0070573~metallodipeptidase activity, IPR001261:ArgE/DapE/ACY1/CPG2/YscS, conserved site,IPR002933:Peptidase M20,IPR010159:N-acyl-L-amino-acid amidohydrolase,IPR011650:Peptidase M20, dimerisation domain, rno00220:Arginine biosynthesis,rno01100:Metabolic pathways,rno01130:Biosynthesis of antibiotics,rno01210:2-Oxocarboxylic acid metabolism,rno01230:Biosynthesis of amino acids, PIRSF036696:acyl-amino-acid amidohydrolase 1, Complete proteome,Cytoplasm,Direct protein sequencing,Hydrolase,Metal-binding,Phosphoprotein,Reference proteome,Zinc, active site:Proton acceptor,chain:Aminoacylase-1A,chain:Aminoacylase-1B,metal ion-binding site:Zinc 1,metal ion-binding site:Zinc 2,sequence conflict, Q11011 aminopeptidase puromycin sensitive(Npepps) Mus musculus Amino acid transport and metabolism, GO:0006508~proteolysis,GO:0043171~peptide catabolic process,GO:0071456~cellular response to hypoxia,GO:1903955~positive regulation of protein targeting to mitochondrion, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0070062~extracellular exosome, GO:0004177~aminopeptidase activity,GO:0008233~peptidase activity,GO:0008237~metallopeptidase activity,GO:0008270~zinc ion binding,GO:0016787~hydrolase activity,GO:0042277~peptide binding,GO:0046872~metal ion binding,GO:0070006~metalloaminopeptidase activity, IPR001930:Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase,IPR014782:Peptidase M1, membrane alanine aminopeptidase, N-terminal,IPR024571:Domain of unknown function DUF3358, Aminopeptidase,Complete proteome,Cytoplasm,Hydrolase,Metal-binding,Metalloprotease,Nitration,Nucleus,Protease,Proteomics identification,Reference proteome,Zinc, active site:Proton donor,chain:Puromycin-sensitive aminopeptidase,metal ion-binding site:Zinc; catalytic,modified residue,sequence conflict,short sequence motif:Nuclear localization signal, Q8N7X0 androglobin(ADGB) Homo sapiens GO:0006508~proteolysis, GO:0005622~intracellular,GO:0005737~cytoplasm, GO:0004198~calcium-dependent cysteine-type endopeptidase activity,GO:0019825~oxygen binding,GO:0020037~heme binding, IPR000048:IQ motif, EF-hand binding site,IPR001300:Peptidase C2, calpain, catalytic domain,IPR012292:Globin, structural domain, SM00230:CysPc, Alternative splicing,Coiled coil,Complete proteome,Polymorphism,Proteomics identification,Reference proteome, chain:Calpain-7-like protein,domain:Calpain catalytic,sequence variant, G3UZ78 androglobin(Adgb) Mus musculus GO:0006508~proteolysis, GO:0005622~intracellular,GO:0005737~cytoplasm, GO:0004198~calcium-dependent cysteine-type endopeptidase activity,GO:0019825~oxygen binding,GO:0020037~heme binding, IPR000048:IQ motif, EF-hand binding site,IPR001300:Peptidase C2, calpain, catalytic domain,IPR012292:Globin, structural domain, Alternative splicing,Coiled coil,Complete proteome,Proteomics identification,Reference proteome, Q01484 ankyrin 2(ANK2) Homo sapiens GO:0002027~regulation of heart rate,GO:0003283~atrial septum development,GO:0006874~cellular calcium ion homeostasis,GO:0006888~ER to Golgi vesicle-mediated transport,GO:0007010~cytoskeleton organization,GO:0007165~signal transduction,GO:0010628~positive regulation of gene expression,GO:0010881~regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion,GO:0010882~regulation of cardiac muscle contraction by calcium ion signaling,GO:0030913~paranodal junction assembly,GO:0031647~regulation of protein stability,GO:0033292~T-tubule organization,GO:0033365~protein localization to organelle,GO:0034394~protein localization to cell surface,GO:0034613~cellular protein localization,GO:0036309~protein localization to M-band,GO:0036371~protein localization to T-tubule,GO:0043268~positive regulation of potassium ion transport,GO:0050821~protein stabilization,GO:0051279~regulation of release of sequestered calcium ion into cytosol,GO:0051597~response to methylmercury,GO:0051924~regulation of calcium ion transport,GO:0051928~positive regulation of calcium ion transport,GO:0055117~regulation of cardiac muscle contraction,GO:0060307~regulation of ventricular cardiac muscle cell membrane repolarization,GO:0070296~sarcoplasmic reticulum calcium ion transport,GO:0070972~protein localization to endoplasmic reticulum,GO:0072659~protein localization to plasma membrane,GO:0072661~protein targeting to plasma membrane,GO:0086004~regulation of cardiac muscle cell contraction,GO:0086005~ventricular cardiac muscle cell action potential,GO:0086014~atrial cardiac muscle cell action potential,GO:0086015~SA node cell action potential,GO:0086046~membrane depolarization during SA node cell action potential,GO:0086066~atrial cardiac muscle cell to AV node cell communication,GO:0086070~SA node cell to atrial cardiac muscle cell communication,GO:0086091~regulation of heart rate by cardiac conduction,GO:0098907~regulation of SA node cell action potential,GO:0098910~regulation of atrial cardiac muscle cell action potential,GO:1901018~positive regulation of potassium ion transmembrane transporter activity,GO:1901019~regulation of calcium ion transmembrane transporter activity,GO:1901021~positive regulation of calcium ion transmembrane transporter activity,GO:2001259~positive regulation of cation channel activity, GO:0005622~intracellular,GO:0005829~cytosol,GO:0005856~cytoskeleton,GO:0005886~plasma membrane,GO:0014704~intercalated disc,GO:0016323~basolateral plasma membrane,GO:0016324~apical plasma membrane,GO:0030018~Z disc,GO:0030315~T-tubule,GO:0031430~M band,GO:0031672~A band,GO:0042383~sarcolemma,GO:0043005~neuron projection,GO:0043034~costamere,GO:0045121~membrane raft,GO:0045211~postsynaptic membrane, GO:0005200~structural constituent of cytoskeleton,GO:0005515~protein binding,GO:0008093~cytoskeletal adaptor activity,GO:0019899~enzyme binding,GO:0019901~protein kinase binding,GO:0030507~spectrin binding,GO:0030674~protein binding, bridging,GO:0044325~ion channel binding,GO:0051117~ATPase binding, IPR000488:Death domain,IPR000906:ZU5,IPR002110:Ankyrin repeat,IPR011029:Death-like domain,IPR020683:Ankyrin repeat-containing domain, hsa05205:Proteoglycans in cancer, 600919~Cardiac arrhythmia, ankyrin-B-related,600919~Long QT syndrome 4, SM00005:DEATH,SM00218:ZU5,SM00248:ANK, 3D-structure,Alternative splicing,ANK repeat,Cell junction,Cell membrane,Complete proteome,Cytoplasm,Cytoskeleton,Disease mutation,Long QT syndrome,Membrane,Phosphoprotein,Polymorphism,Postsynaptic cell membrane,Proteomics identification,Reference proteome,Repeat,Synapse, chain:Ankyrin-2,domain:Death,domain:ZU5,modified residue,mutagenesis site,region of interest:Interaction with SPTBN1,region of interest:Repeat-rich region,repeat:ANK 1,repeat:ANK 10,repeat:ANK 11,repeat:ANK 12,repeat:ANK 13,repeat:ANK 14,repeat:ANK 15,repeat:ANK 16,repeat:ANK 17,repeat:ANK 18,repeat:ANK 19,repeat:ANK 2,repeat:ANK 20,repeat:ANK 21,repeat:ANK 22,repeat:ANK 23,repeat:ANK 24,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5,repeat:ANK 6,repeat:ANK 7,repeat:ANK 8,repeat:ANK 9,repeat:Repeat A,repeat:Repeat A; approximate,sequence conflict,sequence variant,splice variant, Q6ZPS6 ankyrin repeat and IBR domain containing 1(Ankib1) Mus musculus GO:0000209~protein polyubiquitination,GO:0016567~protein ubiquitination,GO:0032436~positive regulation of proteasomal ubiquitin-dependent protein catabolic process,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process, GO:0000151~ubiquitin ligase complex,GO:0005737~cytoplasm, GO:0004842~ubiquitin-protein transferase activity,GO:0008270~zinc ion binding,GO:0031624~ubiquitin conjugating enzyme binding,GO:0046872~metal ion binding,GO:0061630~ubiquitin protein ligase activity, IPR001841:Zinc finger, RING-type,IPR002110:Ankyrin repeat,IPR002867:Zinc finger, C6HC-type,IPR003903:Ubiquitin interacting motif,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR020683:Ankyrin repeat-containing domain, SM00184:RING,SM00248:ANK,SM00647:IBR, ANK repeat,Coiled coil,Complete proteome,Lipoprotein,Metal-binding,Myristate,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Transferase,Zinc,Zinc-finger, chain:Ankyrin repeat and IBR domain-containing protein 1,modified residue,repeat:ANK 1,repeat:ANK 2,repeat:UIM,zinc finger region:IBR-type 1; degenerate,zinc finger region:RING-type 1; atypical,zinc finger region:RING-type 2, Q66H85 ankyrin repeat and zinc finger domain containing 1(Ankzf1) Rattus norvegicus GO:0030433~ER-associated ubiquitin-dependent protein catabolic process,GO:0071630~nucleus-associated proteasomal ubiquitin-dependent protein catabolic process,GO:0072671~mitochondria-associated ubiquitin-dependent protein catabolic process, GO:0016020~membrane,GO:0036266~Cdc48p-Npl4p-Vms1p AAA ATPase complex, GO:0004843~thiol-dependent ubiquitin-specific protease activity,GO:0046872~metal ion binding, IPR002110:Ankyrin repeat,IPR007087:Zinc finger, C2H2,IPR020683:Ankyrin repeat-containing domain, SM00248:ANK, ANK repeat,Coiled coil,Complete proteome,Metal-binding,Phosphoprotein,Reference proteome,Repeat,Zinc,Zinc-finger, chain:Ankyrin repeat and zinc finger domain- containing protein 1,modified residue,repeat:ANK 1,repeat:ANK 2,zinc finger region:C2H2-type, Q9UPS8 ankyrin repeat domain 26(ANKRD26) Homo sapiens DNA replication, recombination, and repair, GO:0005813~centrosome, IPR002110:Ankyrin repeat,IPR020683:Ankyrin repeat-containing domain,IPR021885:Protein of unknown function DUF3496, 188000~Thrombocytopenia 2, SM00248:ANK, Alternative splicing,ANK repeat,Coiled coil,Complete proteome,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat, chain:Ankyrin repeat domain-containing protein 26,compositionally biased region:Poly-Asp,compositionally biased region:Poly-Gly,modified residue,repeat:ANK 1,repeat:ANK 2,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5,sequence conflict,sequence variant,splice variant, O15084 ankyrin repeat domain 28(ANKRD28) Homo sapiens General function prediction only, GO:0048208~COPII vesicle coating, GO:0000139~Golgi membrane,GO:0005654~nucleoplasm,GO:0005829~cytosol, GO:0005515~protein binding, IPR002110:Ankyrin repeat,IPR020683:Ankyrin repeat-containing domain, SM00248:ANK, Alternative promoter usage,Alternative splicing,ANK repeat,Complete proteome,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat, chain:Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A,modified residue,mutagenesis site,repeat:ANK 1,repeat:ANK 10,repeat:ANK 11,repeat:ANK 12,repeat:ANK 13,repeat:ANK 14,repeat:ANK 15,repeat:ANK 16,repeat:ANK 17,repeat:ANK 18,repeat:ANK 19,repeat:ANK 2,repeat:ANK 20,repeat:ANK 21,repeat:ANK 22,repeat:ANK 23,repeat:ANK 24,repeat:ANK 25,repeat:ANK 26,repeat:ANK 27,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5,repeat:ANK 6,repeat:ANK 7,repeat:ANK 8,repeat:ANK 9,sequence conflict,splice variant, Q5F478 ankyrin repeat domain 44(ANKRD44) Gallus gallus General function prediction only, IPR002110:Ankyrin repeat,IPR020683:Ankyrin repeat-containing domain, SM00248:ANK, ANK repeat,Coiled coil,Complete proteome,Reference proteome,Repeat, chain:Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B,repeat:ANK 1,repeat:ANK 10,repeat:ANK 11,repeat:ANK 12,repeat:ANK 13,repeat:ANK 14,repeat:ANK 15,repeat:ANK 16,repeat:ANK 17,repeat:ANK 18,repeat:ANK 19,repeat:ANK 2,repeat:ANK 20,repeat:ANK 21,repeat:ANK 22,repeat:ANK 23,repeat:ANK 24,repeat:ANK 25,repeat:ANK 26,repeat:ANK 27,repeat:ANK 28,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5,repeat:ANK 6,repeat:ANK 7,repeat:ANK 8,repeat:ANK 9, Q8BLD6 ankyrin repeat domain 55(Ankrd55) Mus musculus IPR002110:Ankyrin repeat,IPR020683:Ankyrin repeat-containing domain, SM00248:ANK, ANK repeat,Complete proteome,Phosphoprotein,Reference proteome,Repeat, chain:Ankyrin repeat domain-containing protein 55,repeat:ANK 1,repeat:ANK 2,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5,repeat:ANK 6,repeat:ANK 7,repeat:ANK 8,repeat:ANK 9,sequence conflict, Q9Y2G4 ankyrin repeat domain 6(ANKRD6) Homo sapiens GO:0046330~positive regulation of JNK cascade,GO:0090090~negative regulation of canonical Wnt signaling pathway,GO:2000096~positive regulation of Wnt signaling pathway, planar cell polarity pathway, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0043231~intracellular membrane-bounded organelle, IPR002110:Ankyrin repeat,IPR020683:Ankyrin repeat-containing domain, SM00248:ANK, Alternative splicing,ANK repeat,Coiled coil,Complete proteome,Isopeptide bond,Polymorphism,Proteomics identification,Reference proteome,Repeat, chain:Ankyrin repeat domain-containing protein 6,compositionally biased region:Poly-Pro,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),repeat:ANK 1,repeat:ANK 2,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5,repeat:ANK 6,repeat:ANK 7,repeat:ANK 8,sequence conflict,sequence variant,splice variant, Q69ZU8 ankyrin repeat domain 6(Ankrd6) Mus musculus GO:0046330~positive regulation of JNK cascade,GO:0090090~negative regulation of canonical Wnt signaling pathway,GO:2000096~positive regulation of Wnt signaling pathway, planar cell polarity pathway, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0043231~intracellular membrane-bounded organelle, GO:0005515~protein binding, IPR002110:Ankyrin repeat,IPR020683:Ankyrin repeat-containing domain, SM00248:ANK, Alternative splicing,ANK repeat,Coiled coil,Complete proteome,Isopeptide bond,Reference proteome,Repeat, chain:Ankyrin repeat domain-containing protein 6,compositionally biased region:Poly-Pro,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),repeat:ANK 1,repeat:ANK 2,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5,repeat:ANK 6,repeat:ANK 7,repeat:ANK 8,splice variant, Q6PB70 anoctamin 8(Ano8) Mus musculus GO:0006821~chloride transport, GO:0005622~intracellular,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0005229~intracellular calcium activated chloride channel activity,GO:0017128~phospholipid scramblase activity, IPR007632:Anoctamin/TMEM 16, Acetylation,Cell membrane,Complete proteome,Glycoprotein,Membrane,Methylation,Phosphoprotein,Reference proteome,Transmembrane,Transmembrane helix, chain:Anoctamin-8,compositionally biased region:Arg-rich,compositionally biased region:Glu-rich,compositionally biased region:Leu-rich,compositionally biased region:Pro-rich,glycosylation site:N-linked (GlcNAc...),sequence conflict,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q32L08 antagonist of mitotic exit network 1 homolog(AMN1) Bos taurus IPR001611:Leucine-rich repeat,IPR006553:Leucine-rich repeat, cysteine-containing subtype, SM00367:LRR_CC, Complete proteome,Reference proteome, chain:Protein AMN1 homolog, B7QDG3 apolipoprotein A-I-binding protein, putative(IscW_ISCW022186) Ixodes scapularis GO:0005739~mitochondrion, GO:0000166~nucleotide binding,GO:0046872~metal ion binding,GO:0052856~NADHX epimerase activity,GO:0052857~NADPHX epimerase activity, IPR004443:YjeF N-terminal domain, Complete proteome,Isomerase,Metal-binding,NAD,NADP,Nucleotide-binding,Potassium,Reference proteome, Q5R4A6 archaelysin family metallopeptidase 2(AMZ2) Pongo abelii GO:0008237~metallopeptidase activity,GO:0008270~zinc ion binding, IPR012962:Peptidase M54, archaemetzincin,IPR024079:Metallopeptidase, catalytic domain, Complete proteome,Hydrolase,Metal-binding,Metalloprotease,Protease,Reference proteome,Zinc, chain:Archaemetzincin-2,metal ion-binding site:Zinc; catalytic, Q9UKV8 argonaute 2, RISC catalytic component(AGO2) Homo sapiens h_dicerPathway:Dicer Pathway, GO:0006351~transcription, DNA-templated,GO:0006412~translation,GO:0006413~translational initiation,GO:0007223~Wnt signaling pathway, calcium modulating pathway,GO:0009791~post-embryonic development,GO:0010501~RNA secondary structure unwinding,GO:0010586~miRNA metabolic process,GO:0031047~gene silencing by RNA,GO:0031054~pre-miRNA processing,GO:0035087~siRNA loading onto RISC involved in RNA interference,GO:0035194~posttranscriptional gene silencing by RNA,GO:0035196~production of miRNAs involved in gene silencing by miRNA,GO:0035278~miRNA mediated inhibition of translation,GO:0035279~mRNA cleavage involved in gene silencing by miRNA,GO:0035280~miRNA loading onto RISC involved in gene silencing by miRNA,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0045947~negative regulation of translational initiation,GO:0048015~phosphatidylinositol-mediated signaling,GO:0060213~positive regulation of nuclear-transcribed mRNA poly(A) tail shortening,GO:0090502~RNA phosphodiester bond hydrolysis, endonucleolytic,GO:0090625~mRNA cleavage involved in gene silencing by siRNA,GO:1900153~positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, GO:0000932~cytoplasmic mRNA processing body,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005844~polysome,GO:0005845~mRNA cap binding complex,GO:0016020~membrane,GO:0016442~RISC complex,GO:0030425~dendrite,GO:0030529~intracellular ribonucleoprotein complex,GO:0035068~micro-ribonucleoprotein complex,GO:0070578~RISC-loading complex, GO:0000340~RNA 7-methylguanosine cap binding,GO:0000993~RNA polymerase II core binding,GO:0001047~core promoter binding,GO:0003676~nucleic acid binding,GO:0003725~double-stranded RNA binding,GO:0003727~single-stranded RNA binding,GO:0003729~mRNA binding,GO:0003743~translation initiation factor activity,GO:0004521~endoribonuclease activity,GO:0005515~protein binding,GO:0008022~protein C-terminus binding,GO:0016443~bidentate ribonuclease III activity,GO:0035197~siRNA binding,GO:0035198~miRNA binding,GO:0044822~poly(A) RNA binding,GO:0046872~metal ion binding,GO:0070551~endoribonuclease activity, cleaving siRNA-paired mRNA,GO:0090624~endoribonuclease activity, cleaving miRNA-paired mRNA,GO:0098808~mRNA cap binding, IPR003100:Argonaute/Dicer protein, PAZ,IPR003165:Stem cell self-renewal protein Piwi,IPR012337:Ribonuclease H-like domain,IPR014811:Domain of unknown function DUF1785, SM00949:SM00949,SM00950:SM00950,SM01163:SM01163, 3D-structure,Alternative splicing,Complete proteome,Cytoplasm,Endonuclease,Hydrolase,Hydroxylation,Magnesium,Manganese,Metal-binding,Nitration,Nuclease,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repressor,Ribonucleoprotein,RNA-binding,RNA-mediated gene silencing,Transcription,Transcription regulation,Translation regulation, chain:Protein argonaute-2,domain:PAZ,domain:Piwi,metal ion-binding site:Divalent metal cation,modified residue,mutagenesis site,sequence conflict,splice variant, B1WBW4 armadillo repeat containing 10(Armc10) Rattus norvegicus GO:0040008~regulation of growth, GO:0005739~mitochondrion,GO:0005789~endoplasmic reticulum membrane,GO:0016021~integral component of membrane, IPR006911:Armadillo repeat-containing domain,IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold, Complete proteome,Endoplasmic reticulum,Growth regulation,Membrane,Phosphoprotein,Reference proteome,Transmembrane,Transmembrane helix, chain:Armadillo repeat-containing protein 10,modified residue,repeat:ARM,transmembrane region, Q8BNU0 armadillo repeat containing 6(Armc6) Mus musculus GO:0002244~hematopoietic progenitor cell differentiation, IPR000225:Armadillo,IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold, SM00185:ARM, Alternative splicing,Complete proteome,Phosphoprotein,Proteomics identification,Reference proteome,Repeat, chain:Armadillo repeat-containing protein 6,modified residue,repeat:ARM 1,repeat:ARM 2,repeat:ARM 3,repeat:ARM 4,sequence conflict,splice variant, Q5R629 armadillo repeat containing 9(ARMC9) Pongo abelii IPR006594:LisH dimerisation motif,IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold, SM00667:LisH, Coiled coil,Complete proteome,Phosphoprotein,Reference proteome, chain:LisH domain-containing protein ARMC9,domain:LisH, Q96B67 arrestin domain containing 3(ARRDC3) Homo sapiens GO:0001659~temperature homeostasis,GO:0007165~signal transduction,GO:0031651~negative regulation of heat generation,GO:0043588~skin development,GO:0044252~negative regulation of multicellular organismal metabolic process,GO:0051443~positive regulation of ubiquitin-protein transferase activity,GO:0060613~fat pad development,GO:0071879~positive regulation of adrenergic receptor signaling pathway,GO:0090327~negative regulation of locomotion involved in locomotory behavior, GO:0005764~lysosome,GO:0005768~endosome,GO:0005769~early endosome,GO:0005886~plasma membrane, GO:0005515~protein binding,GO:0031699~beta-3 adrenergic receptor binding, IPR011021:Arrestin-like, N-terminal,IPR011022:Arrestin C-terminal-like domain,IPR014756:Immunoglobulin E-set, SM01017:SM01017, 3D-structure,Cell membrane,Complete proteome,Cytoplasm,Endosome,Lysosome,Membrane,Reference proteome,Repeat, chain:Arrestin domain-containing protein 3,sequence conflict, Q5R5L7 arrestin domain containing 3(ARRDC3) Pongo abelii GO:0001659~temperature homeostasis,GO:0007165~signal transduction,GO:0031651~negative regulation of heat generation,GO:0043588~skin development,GO:0044252~negative regulation of multicellular organismal metabolic process,GO:0051443~positive regulation of ubiquitin-protein transferase activity,GO:0060613~fat pad development,GO:0071879~positive regulation of adrenergic receptor signaling pathway,GO:0090327~negative regulation of locomotion involved in locomotory behavior, GO:0005764~lysosome,GO:0005768~endosome,GO:0005769~early endosome,GO:0005886~plasma membrane, IPR011021:Arrestin-like, N-terminal,IPR011022:Arrestin C-terminal-like domain,IPR014756:Immunoglobulin E-set, SM01017:SM01017, Cell membrane,Complete proteome,Cytoplasm,Endosome,Lysosome,Membrane,Reference proteome,Repeat, chain:Arrestin domain-containing protein 3, Q566U4 arylformamidase(afmid) Danio rerio GO:0006569~tryptophan catabolic process,GO:0008152~metabolic process,GO:0019441~tryptophan catabolic process to kynurenine,GO:0034354~'de novo' NAD biosynthetic process from tryptophan, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0004061~arylformamidase activity,GO:0016787~hydrolase activity, IPR013094:Alpha/beta hydrolase fold-3,IPR027519:Kynurenine formamidase, dre00380:Tryptophan metabolism,dre00630:Glyoxylate and dicarboxylate metabolism,dre01100:Metabolic pathways, Alternative splicing,Complete proteome,Cytoplasm,Hydrolase,Nucleus,Proteomics identification,Reference proteome,Tryptophan catabolism, chain:Probable arylformamidase,splice variant, Q9ULK2 ataxin 7 like 1(ATXN7L1) Homo sapiens GO:0005515~protein binding, IPR013243:SCA7 domain, Alternative splicing,Complete proteome,Proteomics identification,Reference proteome, chain:Ataxin-7-like protein 1,compositionally biased region:Poly-Thr,compositionally biased region:Ser-rich,domain:SCA7,splice variant, Q6ZNE5 autophagy related 14(ATG14) Homo sapiens GO:0000045~autophagosome assembly,GO:0001932~regulation of protein phosphorylation,GO:0001933~negative regulation of protein phosphorylation,GO:0001934~positive regulation of protein phosphorylation,GO:0008333~endosome to lysosome transport,GO:0009267~cellular response to starvation,GO:0010508~positive regulation of autophagy,GO:0010608~posttranscriptional regulation of gene expression,GO:0016236~macroautophagy,GO:0042149~cellular response to glucose starvation,GO:0043552~positive regulation of phosphatidylinositol 3-kinase activity,GO:0061635~regulation of protein complex stability,GO:0090207~regulation of triglyceride metabolic process,GO:0098779~mitophagy in response to mitochondrial depolarization, GO:0000421~autophagosome membrane,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005776~autophagosome,GO:0005789~endoplasmic reticulum membrane,GO:0005829~cytosol,GO:0005930~axoneme,GO:0034045~pre-autophagosomal structure membrane,GO:0035032~phosphatidylinositol 3-kinase complex, class III,GO:0044233~ER-mitochondrion membrane contact site,GO:0045335~phagocytic vesicle,GO:0097629~extrinsic component of omegasome membrane,GO:0097632~extrinsic component of pre-autophagosomal structure membrane, GO:0005515~protein binding, IPR018791:UV radiation resistance protein/autophagy-related protein 14, hsa04140:Regulation of autophagy, Alternative splicing,Autophagy,Coiled coil,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Endoplasmic reticulum,Membrane,Phosphoprotein,Polymorphism,Reference proteome, chain:Uncharacterized protein KIAA0831,modified residue,sequence conflict,sequence variant,splice variant, Q13490 baculoviral IAP repeat containing 2(BIRC2) Homo sapiens h_caspasePathway:Caspase Cascade in Apoptosis,h_deathPathway:Induction of apoptosis through DR3 and DR4/5 Death Receptors ,h_hivnefPathway:HIV-I Nef: negative effector of Fas and TNF,h_mitochondriaPathway:Role of Mitochondria in Apoptotic Signaling, GO:0000209~protein polyubiquitination,GO:0001666~response to hypoxia,GO:0001890~placenta development,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006921~cellular component disassembly involved in execution phase of apoptosis,GO:0007166~cell surface receptor signaling pathway,GO:0007249~I-kappaB kinase/NF-kappaB signaling,GO:0010803~regulation of tumor necrosis factor-mediated signaling pathway,GO:0010939~regulation of necrotic cell death,GO:0033209~tumor necrosis factor-mediated signaling pathway,GO:0034121~regulation of toll-like receptor signaling pathway,GO:0035666~TRIF-dependent toll-like receptor signaling pathway,GO:0038061~NIK/NF-kappaB signaling,GO:0039535~regulation of RIG-I signaling pathway,GO:0042127~regulation of cell proliferation,GO:0042981~regulation of apoptotic process,GO:0043066~negative regulation of apoptotic process,GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling,GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process,GO:0045088~regulation of innate immune response,GO:0045471~response to ethanol,GO:0045595~regulation of cell differentiation,GO:0050727~regulation of inflammatory response,GO:0051291~protein heterooligomerization,GO:0051591~response to cAMP,GO:0051726~regulation of cell cycle,GO:0060544~regulation of necroptotic process,GO:0070266~necroptotic process,GO:0070424~regulation of nucleotide-binding oligomerization domain containing signaling pathway,GO:0090307~mitotic spindle assembly,GO:1902443~negative regulation of ripoptosome assembly involved in necroptotic process,GO:1902523~positive regulation of protein K63-linked ubiquitination,GO:1902524~positive regulation of protein K48-linked ubiquitination,GO:1902527~positive regulation of protein monoubiquitination,GO:1990001~inhibition of cysteine-type endopeptidase activity involved in apoptotic process,GO:2000116~regulation of cysteine-type endopeptidase activity,GO:2000377~regulation of reactive oxygen species metabolic process, GO:0001741~XY body,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005876~spindle microtubule,GO:0009898~cytoplasmic side of plasma membrane,GO:0035631~CD40 receptor complex,GO:0043234~protein complex,GO:0045121~membrane raft, GO:0003713~transcription coactivator activity,GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0016740~transferase activity,GO:0016874~ligase activity,GO:0043027~cysteine-type endopeptidase inhibitor activity involved in apoptotic process,GO:0043130~ubiquitin binding,GO:0047485~protein N-terminus binding,GO:0051087~chaperone binding,GO:0098770~FBXO family protein binding, IPR001315:Caspase Recruitment,IPR001370:Baculoviral inhibition of apoptosis protein repeat,IPR001841:Zinc finger, RING-type,IPR011029:Death-like domain, hsa04064:NF-kappa B signaling pathway,hsa04120:Ubiquitin mediated proteolysis,hsa04210:Apoptosis,hsa04510:Focal adhesion,hsa04621:NOD-like receptor signaling pathway,hsa04668:TNF signaling pathway,hsa05145:Toxoplasmosis,hsa05200:Pathways in cancer,hsa05222:Small cell lung cancer, SM00114:CARD,SM00184:RING,SM00238:BIR, 3D-structure,Activator,Alternative splicing,Apoptosis,Coiled coil,Complete proteome,Cytoplasm,Metal-binding,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,Transferase,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, chain:Baculoviral IAP repeat-containing protein 2,domain:CARD,helix,metal ion-binding site:Zinc,repeat:BIR 1,repeat:BIR 2,repeat:BIR 3,sequence conflict,sequence variant,strand,turn,zinc finger region:RING-type, A1E2V0 baculoviral IAP repeat containing 3(BIRC3) Canis lupus familiaris Function unknown, GO:0006915~apoptotic process,GO:0016567~protein ubiquitination,GO:0031398~positive regulation of protein ubiquitination,GO:0034121~regulation of toll-like receptor signaling pathway,GO:0060546~negative regulation of necroptotic process,GO:0090307~mitotic spindle assembly,GO:1990001~inhibition of cysteine-type endopeptidase activity involved in apoptotic process, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005876~spindle microtubule, GO:0004842~ubiquitin-protein transferase activity,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0043027~cysteine-type endopeptidase inhibitor activity involved in apoptotic process, IPR001315:Caspase Recruitment,IPR001370:Baculoviral inhibition of apoptosis protein repeat,IPR001841:Zinc finger, RING-type,IPR011029:Death-like domain, cfa04064:NF-kappa B signaling pathway,cfa04120:Ubiquitin mediated proteolysis,cfa04210:Apoptosis,cfa04510:Focal adhesion,cfa04621:NOD-like receptor signaling pathway,cfa04668:TNF signaling pathway,cfa05145:Toxoplasmosis,cfa05200:Pathways in cancer,cfa05222:Small cell lung cancer, SM00114:CARD,SM00184:RING,SM00238:BIR, Apoptosis,Complete proteome,Cytoplasm,Metal-binding,Nucleus,Reference proteome,Repeat,Transferase,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, chain:Baculoviral IAP repeat-containing protein 3,domain:CARD,metal ion-binding site:Zinc,repeat:BIR 1,repeat:BIR 2,repeat:BIR 3,zinc finger region:RING-type, A9JTP3 baculoviral IAP repeat containing 7(birc7) Xenopus tropicalis GO:0007275~multicellular organism development,GO:0009966~regulation of signal transduction,GO:0043066~negative regulation of apoptotic process,GO:0043154~negative regulation of cysteine-type endopeptidase activity involved in apoptotic process,GO:0051865~protein autoubiquitination,GO:0090307~mitotic spindle assembly,GO:1990001~inhibition of cysteine-type endopeptidase activity involved in apoptotic process, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005876~spindle microtubule, GO:0004842~ubiquitin-protein transferase activity,GO:0004869~cysteine-type endopeptidase inhibitor activity,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0043027~cysteine-type endopeptidase inhibitor activity involved in apoptotic process, IPR001370:Baculoviral inhibition of apoptosis protein repeat,IPR001841:Zinc finger, RING-type, xtr04120:Ubiquitin mediated proteolysis, SM00184:RING,SM00238:BIR, Apoptosis,Complete proteome,Cytoplasm,Developmental protein,Metal-binding,Phosphoprotein,Protease inhibitor,Reference proteome,Repeat,Thiol protease inhibitor,Transferase,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, chain:Baculoviral IAP repeat-containing protein 7,metal ion-binding site:Zinc,modified residue,region of interest:Self-inhibits the anti-apoptotic function,repeat:BIR 1,repeat:BIR 2,zinc finger region:RING-type, M9NDE3 bark beetle(bark) Drosophila melanogaster GO:0034976~response to endoplasmic reticulum stress,GO:0035002~liquid clearance, open tracheal system,GO:0035159~regulation of tube length, open tracheal system,GO:0045217~cell-cell junction maintenance,GO:0090557~establishment of endothelial intestinal barrier,GO:1904274~tricellular tight junction assembly, GO:0005886~plasma membrane,GO:0005912~adherens junction,GO:0005918~septate junction,GO:0005923~bicellular tight junction,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0061689~tricellular tight junction, GO:0005044~scavenger receptor activity,GO:0030246~carbohydrate binding, IPR000859:CUB domain,IPR001190:Speract/scavenger receptor,IPR006626:Parallel beta-helix repeat,IPR011050:Pectin lyase fold/virulence factor,IPR012334:Pectin lyase fold,IPR016186:C-type lectin-like,IPR016187:C-type lectin fold,IPR017448:Speract/scavenger receptor-related, SM00202:SR,SM00710:PbH1, Alternative splicing,Cell junction,Cell membrane,Complete proteome,Disulfide bond,Glycoprotein,Membrane,Reference proteome,Repeat,Signal,Tight junction,Transmembrane,Transmembrane helix, Q63276 bile acid CoA:amino acid N-acyltransferase(Baat) Rattus norvegicus GO:0001889~liver development,GO:0002152~bile acid conjugation,GO:0006544~glycine metabolic process,GO:0006631~fatty acid metabolic process,GO:0006637~acyl-CoA metabolic process,GO:0006699~bile acid biosynthetic process,GO:0008206~bile acid metabolic process,GO:0019530~taurine metabolic process,GO:0031100~organ regeneration, GO:0005777~peroxisome,GO:0005829~cytosol, GO:0005102~receptor binding,GO:0016290~palmitoyl-CoA hydrolase activity,GO:0016410~N-acyltransferase activity,GO:0047963~glycine N-choloyltransferase activity,GO:0052689~carboxylic ester hydrolase activity,GO:0052815~medium-chain acyl-CoA hydrolase activity,GO:0052816~long-chain acyl-CoA hydrolase activity,GO:0052817~very long chain acyl-CoA hydrolase activity, IPR006862:Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase,IPR014940:BAAT/Acyl-CoA thioester hydrolase C-terminal,IPR016662:Acyl-CoA thioesterase, long chain, rno00120:Primary bile acid biosynthesis,rno00430:Taurine and hypotaurine metabolism,rno01040:Biosynthesis of unsaturated fatty acids,rno01100:Metabolic pathways,rno04146:Peroxisome,rno04976:Bile secretion, PIRSF016521:acyl-CoA thioesterase (hydrolase), Acyltransferase,Complete proteome,Fatty acid metabolism,Hydrolase,Lipid metabolism,Peroxisome,Phosphoprotein,Reference proteome,Serine esterase,Transferase, active site:Charge relay system,chain:Bile acid-CoA:amino acid N- acyltransferase,sequence conflict, P87362 bleomycin hydrolase(BLMH) Gallus gallus GO:0006508~proteolysis,GO:0009636~response to toxic substance,GO:0042493~response to drug,GO:0043418~homocysteine catabolic process, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0070062~extracellular exosome, GO:0004177~aminopeptidase activity,GO:0004197~cysteine-type endopeptidase activity,GO:0008234~cysteine-type peptidase activity, IPR000169:Cysteine peptidase, cysteine active site,IPR004134:Peptidase C1B, bleomycin hydrolase, PIRSF005700:aminopeptidase C (bleomycin hydrolase), Aminopeptidase,Complete proteome,Cytoplasm,Hydrolase,Protease,Reference proteome,Thiol protease, chain:Bleomycin hydrolase, I6V1W0 brambleberry(bmb) Danio rerio Function unknown, GO:0000741~karyogamy,GO:0007344~pronuclear fusion,GO:0061472~karyomere membrane fusion, GO:0005634~nucleus,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0031965~nuclear membrane, Complete proteome,Karyogamy,Membrane,Nucleus,Reference proteome,Signal,Transmembrane,Transmembrane helix, P21839 branched chain keto acid dehydrogenase E1 subunit beta(BCKDHB) Bos taurus GO:0008152~metabolic process,GO:0009083~branched-chain amino acid catabolic process,GO:0055114~oxidation-reduction process, GO:0005759~mitochondrial matrix,GO:0005947~mitochondrial alpha-ketoglutarate dehydrogenase complex, GO:0003824~catalytic activity,GO:0003826~alpha-ketoacid dehydrogenase activity,GO:0003863~3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity, IPR005475:Transketolase-like, pyrimidine-binding domain,IPR009014:Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II, bta00280:Valine, leucine and isoleucine degradation,bta01100:Metabolic pathways,bta01130:Biosynthesis of antibiotics, SM00861:SM00861, Acetylation,Complete proteome,Direct protein sequencing,Mitochondrion,Oxidoreductase,Reference proteome,Signal,Transit peptide, chain:2-oxoisovalerate dehydrogenase subunit beta, mitochondrial,modified residue,sequence conflict,transit peptide:Mitochondrion, Q9NRL2 bromodomain adjacent to zinc finger domain 1A(BAZ1A) Homo sapiens GO:0006261~DNA-dependent DNA replication,GO:0006338~chromatin remodeling,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0008623~CHRAC,GO:0016590~ACF complex, GO:0004402~histone acetyltransferase activity,GO:0005515~protein binding,GO:0008270~zinc ion binding, IPR001487:Bromodomain,IPR001965:Zinc finger, PHD-type,IPR011011:Zinc finger, FYVE/PHD-type,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR013136:WSTF/Acf1/Cbp146,IPR018359:Bromodomain, conserved site,IPR018501:DDT domain superfamily,IPR019786:Zinc finger, PHD-type, conserved site,IPR019787:Zinc finger, PHD-finger, SM00249:PHD,SM00297:BROMO,SM00571:DDT, Alternative splicing,Bromodomain,Coiled coil,Complete proteome,Metal-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Bromodomain adjacent to zinc finger domain protein 1A,domain:Bromo,domain:DDT,domain:WAC,modified residue,sequence conflict,sequence variant,splice variant,zinc finger region:PHD-type, A2AHJ4 bromodomain and WD repeat domain containing 3(Brwd3) Mus musculus GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0007010~cytoskeleton organization,GO:0008360~regulation of cell shape, GO:0005634~nucleus, IPR001487:Bromodomain,IPR001680:WD40 repeat,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site, SM00297:BROMO,SM00320:WD40, Alternative splicing,Bromodomain,Complete proteome,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,WD repeat, chain:Bromodomain and WD repeat-containing protein 3,compositionally biased region:Gly-rich,compositionally biased region:Poly-Lys,compositionally biased region:Poly-Ser,compositionally biased region:Ser-rich,domain:Bromo 1,domain:Bromo 2,modified residue,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,repeat:WD 8,repeat:WD 9,splice variant, Q91XE9 cAMP responsive element binding protein 3-like 3(Creb3l3) Mus musculus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006986~response to unfolded protein,GO:0030968~endoplasmic reticulum unfolded protein response,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:1990440~positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress, GO:0005634~nucleus,GO:0005783~endoplasmic reticulum,GO:0005789~endoplasmic reticulum membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0000976~transcription regulatory region sequence-specific DNA binding,GO:0000977~RNA polymerase II regulatory region sequence-specific DNA binding,GO:0001228~transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0035497~cAMP response element binding,GO:0042803~protein homodimerization activity,GO:0043565~sequence-specific DNA binding,GO:0046982~protein heterodimerization activity, IPR004827:Basic-leucine zipper domain, mmu04022:cGMP-PKG signaling pathway,mmu04024:cAMP signaling pathway,mmu04151:PI3K-Akt signaling pathway,mmu04152:AMPK signaling pathway,mmu04261:Adrenergic signaling in cardiomyocytes,mmu04668:TNF signaling pathway,mmu04725:Cholinergic synapse,mmu04728:Dopaminergic synapse,mmu04911:Insulin secretion,mmu04915:Estrogen signaling pathway,mmu04916:Melanogenesis,mmu04918:Thyroid hormone synthesis,mmu04922:Glucagon signaling pathway,mmu04925:Aldosterone synthesis and secretion,mmu04931:Insulin resistance,mmu04962:Vasopressin-regulated water reabsorption,mmu05016:Huntington's disease,mmu05030:Cocaine addiction,mmu05031:Amphetamine addiction,mmu05034:Alcoholism,mmu05161:Hepatitis B,mmu05203:Viral carcinogenesis,mmu05215:Prostate cancer, SM00338:BRLZ, Activator,Complete proteome,DNA-binding,Endoplasmic reticulum,Glycoprotein,Membrane,Nucleus,Reference proteome,Signal-anchor,Transcription,Transcription regulation,Transmembrane,Transmembrane helix,Unfolded protein response, chain:Cyclic AMP-responsive element-binding protein 3-like protein 3,chain:Processed cyclic AMP-responsive element- binding protein 3-like protein 3,DNA-binding region:Basic motif,domain:Leucine-zipper,glycosylation site:N-linked (GlcNAc...),modified residue,sequence conflict,site:Cleavage; by PS1,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, O35161 cadherin, EGF LAG seven-pass G-type receptor 1(Celsr1) Mus musculus GO:0001702~gastrulation with mouth forming second,GO:0001736~establishment of planar polarity,GO:0001764~neuron migration,GO:0001843~neural tube closure,GO:0001942~hair follicle development,GO:0007155~cell adhesion,GO:0007156~homophilic cell adhesion via plasma membrane adhesion molecules,GO:0007165~signal transduction,GO:0007166~cell surface receptor signaling pathway,GO:0007186~G-protein coupled receptor signaling pathway,GO:0007266~Rho protein signal transduction,GO:0007267~cell-cell signaling,GO:0007275~multicellular organism development,GO:0007417~central nervous system development,GO:0007626~locomotory behavior,GO:0009952~anterior/posterior pattern specification,GO:0032956~regulation of actin cytoskeleton organization,GO:0042060~wound healing,GO:0042249~establishment of planar polarity of embryonic epithelium,GO:0042472~inner ear morphogenesis,GO:0045176~apical protein localization,GO:0046928~regulation of neurotransmitter secretion,GO:0048105~establishment of body hair planar orientation,GO:0060488~orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis,GO:0060489~planar dichotomous subdivision of terminal units involved in lung branching morphogenesis,GO:0060490~lateral sprouting involved in lung morphogenesis,GO:0090179~planar cell polarity pathway involved in neural tube closure,GO:0090251~protein localization involved in establishment of planar polarity, GO:0005654~nucleoplasm,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0004871~signal transducer activity,GO:0004888~transmembrane signaling receptor activity,GO:0004930~G-protein coupled receptor activity,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0046983~protein dimerization activity, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000203:GPS domain,IPR000742:Epidermal growth factor-like domain,IPR000832:GPCR, family 2, secretin-like,IPR001791:Laminin G domain,IPR001879:GPCR, family 2, extracellular hormone receptor domain,IPR001881:EGF-like calcium-binding,IPR002049:EGF-like, laminin,IPR002126:Cadherin,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR013032:EGF-like, conserved site,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR015919:Cadherin-like,IPR017981:GPCR, family 2-like,IPR020894:Cadherin conserved site, SM00008:HormR,SM00112:CA,SM00179:EGF_CA,SM00180:EGF_Lam,SM00181:EGF,SM00282:LamG,SM00303:GPS, Calcium,Cell membrane,Complete proteome,Developmental protein,Disulfide bond,EGF-like domain,G-protein coupled receptor,Glycoprotein,Hydroxylation,Laminin EGF-like domain,Membrane,Phosphoprotein,Receptor,Reference proteome,Repeat,Signal,Transducer,Transmembrane,Transmembrane helix, chain:Cadherin EGF LAG seven-pass G-type receptor 1,compositionally biased region:Poly-Leu,disulfide bond,domain:Cadherin 1,domain:Cadherin 2,domain:Cadherin 3,domain:Cadherin 4,domain:Cadherin 5,domain:Cadherin 6,domain:Cadherin 7,domain:Cadherin 8,domain:Cadherin 9,domain:EGF-like 1; calcium-binding,domain:EGF-like 2; calcium-binding,domain:EGF-like 3; calcium-binding,domain:EGF-like 4; calcium-binding,domain:EGF-like 5; calcium-binding,domain:EGF-like 6; calcium-binding,domain:EGF-like 7; calcium-binding,domain:EGF-like 8; calcium-binding,domain:GPS,domain:Laminin EGF-like,domain:Laminin G-like 1,domain:Laminin G-like 2,glycosylation site:N-linked (GlcNAc...),modified residue,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, O88427 calcium channel, voltage-dependent, T type, alpha 1H subunit(Cacna1h) Mus musculus GO:0006810~transport,GO:0006811~ion transport,GO:0006816~calcium ion transport,GO:0019233~sensory perception of pain,GO:0032342~aldosterone biosynthetic process,GO:0032870~cellular response to hormone stimulus,GO:0034220~ion transmembrane transport,GO:0034651~cortisol biosynthetic process,GO:0034765~regulation of ion transmembrane transport,GO:0035865~cellular response to potassium ion,GO:0042391~regulation of membrane potential,GO:0045956~positive regulation of calcium ion-dependent exocytosis,GO:0055085~transmembrane transport,GO:0070509~calcium ion import,GO:0070588~calcium ion transmembrane transport,GO:0086010~membrane depolarization during action potential,GO:2000344~positive regulation of acrosome reaction, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0005891~voltage-gated calcium channel complex,GO:0005901~caveola,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030425~dendrite,GO:0042383~sarcolemma,GO:0043204~perikaryon, GO:0005216~ion channel activity,GO:0005244~voltage-gated ion channel activity,GO:0005245~voltage-gated calcium channel activity,GO:0005261~cation channel activity,GO:0005262~calcium channel activity,GO:0005515~protein binding,GO:0008332~low voltage-gated calcium channel activity,GO:0046872~metal ion binding,GO:0097110~scaffold protein binding, IPR005445:Voltage-dependent calcium channel, T-type, alpha-1 subunit,IPR005821:Ion transport domain,IPR027359:Voltage-dependent potassium channel, four helix bundle domain, mmu04010:MAPK signaling pathway,mmu04020:Calcium signaling pathway,mmu04713:Circadian entrainment,mmu04925:Aldosterone synthesis and secretion, Alternative splicing,Calcium,Calcium channel,Calcium transport,Coiled coil,Complete proteome,Glycoprotein,Ion channel,Ion transport,Membrane,Metal-binding,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix,Transport,Voltage-gated channel,Zinc, chain:Voltage-dependent T-type calcium channel subunit alpha-1H,compositionally biased region:Poly-Arg,compositionally biased region:Poly-His,glycosylation site:N-linked (GlcNAc...),modified residue,repeat:I,repeat:II,repeat:III,repeat:IV,sequence conflict,site:Calcium ion selectivity and permeability,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, P07293 calcium voltage-gated channel subunit alpha1 S(CACNA1S) Oryctolagus cuniculus GO:0006936~muscle contraction, GO:0005891~voltage-gated calcium channel complex,GO:0030315~T-tubule,GO:0031674~I band, GO:0005245~voltage-gated calcium channel activity,GO:0008331~high voltage-gated calcium channel activity,GO:0046872~metal ion binding, IPR002077:Voltage-dependent calcium channel, alpha-1 subunit,IPR005446:Voltage-dependent calcium channel, L-type, alpha-1 subunit,IPR005450:Voltage-dependent calcium channel, L-type, alpha-1S subunit,IPR005821:Ion transport domain,IPR014873:Voltage-dependent calcium channel, alpha-1 subunit, IQ domain,IPR027359:Voltage-dependent potassium channel, four helix bundle domain, ocu04010:MAPK signaling pathway,ocu04020:Calcium signaling pathway,ocu04022:cGMP-PKG signaling pathway,ocu04024:cAMP signaling pathway,ocu04260:Cardiac muscle contraction,ocu04261:Adrenergic signaling in cardiomyocytes,ocu04270:Vascular smooth muscle contraction,ocu04723:Retrograde endocannabinoid signaling,ocu04725:Cholinergic synapse,ocu04726:Serotonergic synapse,ocu04727:GABAergic synapse,ocu04911:Insulin secretion,ocu04912:GnRH signaling pathway,ocu04921:Oxytocin signaling pathway,ocu04924:Renin secretion,ocu04925:Aldosterone synthesis and secretion,ocu05010:Alzheimer's disease,ocu05410:Hypertrophic cardiomyopathy (HCM),ocu05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC),ocu05414:Dilated cardiomyopathy, SM01062:SM01062, 3D-structure,Calcium,Calcium channel,Calcium transport,Complete proteome,Direct protein sequencing,Disulfide bond,Glycoprotein,Ion channel,Ion transport,Membrane,Metal-binding,Phosphoprotein,Polymorphism,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Transport,Voltage-gated channel, chain:Voltage-dependent L-type calcium channel subunit alpha-1S,compositionally biased region:Poly-Leu,glycosylation site:N-linked (GlcNAc...),helix,modified residue,region of interest:Binding to the beta subunit,region of interest:Dihydropyridine binding,region of interest:Phenylalkylamine binding,repeat:I,repeat:II,repeat:III,repeat:IV,sequence conflict,sequence variant,site:Calcium ion selectivity and permeability,site:Cleavage,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region,turn, O14936 calcium/calmodulin dependent serine protein kinase(CASK) Homo sapiens h_PDZsPathway:Synaptic Proteins at the Synaptic Junction, GO:0001953~negative regulation of cell-matrix adhesion,GO:0006468~protein phosphorylation,GO:0007155~cell adhesion,GO:0007269~neurotransmitter secretion,GO:0010839~negative regulation of keratinocyte proliferation,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0046037~GMP metabolic process,GO:0046710~GDP metabolic process,GO:0061045~negative regulation of wound healing,GO:0070509~calcium ion import,GO:0090280~positive regulation of calcium ion import,GO:0090288~negative regulation of cellular response to growth factor stimulus, GO:0005604~basement membrane,GO:0005652~nuclear lamina,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005911~cell-cell junction,GO:0005925~focal adhesion,GO:0015629~actin cytoskeleton,GO:0016323~basolateral plasma membrane,GO:0016363~nuclear matrix,GO:0031982~vesicle,GO:0042734~presynaptic membrane,GO:0060170~ciliary membrane, GO:0004385~guanylate kinase activity,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0042043~neurexin family protein binding, IPR000719:Protein kinase, catalytic domain,IPR001452:Src homology-3 domain,IPR001478:PDZ domain,IPR004172:L27,IPR008144:Guanylate kinase,IPR008145:Guanylate kinase/L-type calcium channel,IPR011009:Protein kinase-like domain,IPR011511:Variant SH3,IPR014775:L27, C-terminal,IPR020590:Guanylate kinase, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, 300422~FG syndrome 4,300422~Mental retardation, with or without nystagmus,300749~Mental retardation and microcephaly with pontine and cerebellar hypoplasia, SM00072:GuKc,SM00228:PDZ,SM00326:SH3,SM00569:L27, 3D-structure,Alternative splicing,ATP-binding,Calmodulin-binding,Cell membrane,Complete proteome,Cytoplasm,Disease mutation,Kinase,Membrane,Mental retardation,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Serine/threonine-protein kinase,SH3 domain,Transferase, binding site:ATP,chain:Peripheral plasma membrane protein CASK,domain:Guanylate kinase-like,domain:L27 1,domain:L27 2,domain:PDZ,domain:Protein kinase,domain:SH3,helix,modified residue,nucleotide phosphate-binding region:ATP,region of interest:Calmodulin-binding,sequence conflict,sequence variant,splice variant,strand,turn, O70589 calcium/calmodulin-dependent serine protein kinase (MAGUK family)(Cask) Mus musculus GO:0001953~negative regulation of cell-matrix adhesion,GO:0006468~protein phosphorylation,GO:0006886~intracellular protein transport,GO:0010839~negative regulation of keratinocyte proliferation,GO:0016310~phosphorylation,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0061045~negative regulation of wound healing,GO:0070509~calcium ion import,GO:0090280~positive regulation of calcium ion import,GO:0090288~negative regulation of cellular response to growth factor stimulus, GO:0005604~basement membrane,GO:0005634~nucleus,GO:0005652~nuclear lamina,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005911~cell-cell junction,GO:0005925~focal adhesion,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0016323~basolateral plasma membrane,GO:0016363~nuclear matrix,GO:0030425~dendrite,GO:0031982~vesicle,GO:0042734~presynaptic membrane,GO:0043234~protein complex,GO:0045202~synapse,GO:0060170~ciliary membrane,GO:0097060~synaptic membrane, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0005524~ATP binding,GO:0008022~protein C-terminus binding,GO:0016301~kinase activity,GO:0016740~transferase activity,GO:0030165~PDZ domain binding,GO:0032403~protein complex binding,GO:0042043~neurexin family protein binding, IPR000719:Protein kinase, catalytic domain,IPR001452:Src homology-3 domain,IPR001478:PDZ domain,IPR004172:L27,IPR008144:Guanylate kinase,IPR008145:Guanylate kinase/L-type calcium channel,IPR011009:Protein kinase-like domain,IPR011511:Variant SH3,IPR014775:L27, C-terminal,IPR020590:Guanylate kinase, conserved site,IPR020636:Calcium/calmodulin-dependent/calcium-dependent protein kinase,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00072:GuKc,SM00220:S_TKc,SM00228:PDZ,SM00326:SH3,SM00569:L27, 3D-structure,Alternative splicing,ATP-binding,Calmodulin-binding,Cell membrane,Complete proteome,Cytoplasm,Kinase,Membrane,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Serine/threonine-protein kinase,SH3 domain,Transferase,Transmembrane,Transmembrane helix, binding site:ATP,chain:Peripheral plasma membrane protein CASK,domain:Guanylate kinase-like,domain:L27 1,domain:L27 2,domain:PDZ,domain:Protein kinase,domain:SH3,helix,modified residue,nucleotide phosphate-binding region:ATP,region of interest:Calmodulin-binding,sequence conflict,splice variant, Q5T5Y3 calmodulin regulated spectrin associated protein 1(CAMSAP1) Homo sapiens GO:0007010~cytoskeleton organization,GO:0022604~regulation of cell morphogenesis,GO:0031175~neuron projection development, GO:0005737~cytoplasm,GO:0005874~microtubule, GO:0005516~calmodulin binding,GO:0008017~microtubule binding,GO:0030507~spectrin binding, IPR001715:Calponin homology domain,IPR011033:PRC-barrel-like,IPR014797:CKK domain,IPR022613:Calmodulin-regulated spectrin-associated protein, CH domain, SM01051:SM01051, Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Microtubule,Phosphoprotein,Polymorphism,Reference proteome, chain:Calmodulin-regulated spectrin-associated protein 1,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Ser,domain:CKK,modified residue,sequence conflict,sequence variant,splice variant, Q3U2J5 calmodulin-lysine N-methyltransferase(Camkmt) Mus musculus GO:0007005~mitochondrion organization,GO:0018022~peptidyl-lysine methylation,GO:0032259~methylation, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005794~Golgi apparatus, GO:0008168~methyltransferase activity,GO:0016740~transferase activity,GO:0018025~calmodulin-lysine N-methyltransferase activity, IPR019410:Nicotinamide N-methyltransferase-like,IPR025800:Calmodulin-lysine N-methyltransferase, mmu00310:Lysine degradation, Alternative splicing,Complete proteome,Cytoplasm,Golgi apparatus,Methyltransferase,Nucleus,Reference proteome,S-adenosyl-L-methionine,Transferase, chain:Uncharacterized protein C2orf34 homolog,splice variant, Q9JLG8 calpain 15(Capn15) Mus musculus GO:0006508~proteolysis, GO:0005622~intracellular,GO:0005737~cytoplasm, GO:0004198~calcium-dependent cysteine-type endopeptidase activity,GO:0008233~peptidase activity,GO:0008234~cysteine-type peptidase activity,GO:0008270~zinc ion binding,GO:0016787~hydrolase activity,GO:0046872~metal ion binding, IPR000169:Cysteine peptidase, cysteine active site,IPR001300:Peptidase C2, calpain, catalytic domain,IPR001876:Zinc finger, RanBP2-type,IPR022684:Peptidase C2, calpain family, SM00230:CysPc,SM00547:ZnF_RBZ, Alternative splicing,Complete proteome,Hydrolase,Metal-binding,Phosphoprotein,Protease,Reference proteome,Repeat,Thiol protease,Zinc,Zinc-finger, chain:Calpain-15,compositionally biased region:Glu-rich,domain:Calpain catalytic,modified residue,splice variant,zinc finger region:RanBP2-type 1,zinc finger region:RanBP2-type 2,zinc finger region:RanBP2-type 3,zinc finger region:RanBP2-type 4,zinc finger region:RanBP2-type 5, O15234 cancer susceptibility candidate 3(CASC3) Homo sapiens GO:0000184~nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,GO:0000398~mRNA splicing, via spliceosome,GO:0006369~termination of RNA polymerase II transcription,GO:0006397~mRNA processing,GO:0006405~RNA export from nucleus,GO:0006406~mRNA export from nucleus,GO:0006417~regulation of translation,GO:0008298~intracellular mRNA localization,GO:0016070~RNA metabolic process,GO:0031124~mRNA 3'-end processing, GO:0005654~nucleoplasm,GO:0005829~cytosol,GO:0016607~nuclear speck,GO:0030529~intracellular ribonucleoprotein complex,GO:0035145~exon-exon junction complex,GO:0048471~perinuclear region of cytoplasm, GO:0003723~RNA binding,GO:0005515~protein binding,GO:0019899~enzyme binding,GO:0031625~ubiquitin protein ligase binding,GO:0042802~identical protein binding,GO:0044822~poly(A) RNA binding, IPR018545:Btz domain, hsa03013:RNA transport,hsa03015:mRNA surveillance pathway, SM01044:SM01044, 3D-structure,ADP-ribosylation,Coiled coil,Complete proteome,Cytoplasm,mRNA processing,mRNA splicing,mRNA transport,Nonsense-mediated mRNA decay,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,RNA-binding,Stress response,Translation regulation,Transport,Ubl conjugation, chain:Protein CASC3,compositionally biased region:Poly-Gly,compositionally biased region:Poly-Pro,helix,modified residue,mutagenesis site,region of interest:Necessary for localization in cytoplasmic stress granules,region of interest:Necessary for RNA-binding, interaction with MAGOH and localization in nucleus speckles,region of interest:Sufficient to form the EJC,short sequence motif:Nuclear export signal,short sequence motif:Nuclear localization signal 1,short sequence motif:Nuclear localization signal 2, Q5CZI8 cancer susceptibility candidate 3(casc3) Xenopus tropicalis GO:0000184~nuclear-transcribed mRNA catabolic process, nonsense-mediated decay,GO:0006397~mRNA processing,GO:0006417~regulation of translation,GO:0008380~RNA splicing,GO:0016070~RNA metabolic process,GO:0051028~mRNA transport, GO:0016607~nuclear speck,GO:0035145~exon-exon junction complex,GO:0048471~perinuclear region of cytoplasm, GO:0003723~RNA binding, IPR018545:Btz domain, xtr03013:RNA transport,xtr03015:mRNA surveillance pathway, SM01044:SM01044, Complete proteome,Cytoplasm,mRNA processing,mRNA splicing,mRNA transport,Nonsense-mediated mRNA decay,Nucleus,Reference proteome,RNA-binding,Translation regulation,Transport, chain:Protein CASC3,compositionally biased region:Glu-rich,compositionally biased region:Poly-Arg,compositionally biased region:Pro-rich, P27708 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase(CAD) Homo sapiens 61.Myc_network, Nucleotide transport and metabolism, GO:0000050~urea cycle,GO:0001889~liver development,GO:0006207~'de novo' pyrimidine nucleobase biosynthetic process,GO:0006228~UTP biosynthetic process,GO:0006520~cellular amino acid metabolic process,GO:0006526~arginine biosynthetic process,GO:0006541~glutamine metabolic process,GO:0007507~heart development,GO:0007565~female pregnancy,GO:0007595~lactation,GO:0014075~response to amine,GO:0017144~drug metabolic process,GO:0018107~peptidyl-threonine phosphorylation,GO:0019240~citrulline biosynthetic process,GO:0031000~response to caffeine,GO:0031100~organ regeneration,GO:0032868~response to insulin,GO:0033574~response to testosterone,GO:0035690~cellular response to drug,GO:0042594~response to starvation,GO:0044205~'de novo' UMP biosynthetic process,GO:0046134~pyrimidine nucleoside biosynthetic process,GO:0046777~protein autophosphorylation,GO:0051414~response to cortisol,GO:0071364~cellular response to epidermal growth factor stimulus, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005829~cytosol,GO:0016020~membrane,GO:0016363~nuclear matrix,GO:0042995~cell projection,GO:0043025~neuronal cell body,GO:0043195~terminal bouton,GO:0043234~protein complex,GO:0070062~extracellular exosome, GO:0004070~aspartate carbamoyltransferase activity,GO:0004087~carbamoyl-phosphate synthase (ammonia) activity,GO:0004088~carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity,GO:0004151~dihydroorotase activity,GO:0004672~protein kinase activity,GO:0005524~ATP binding,GO:0008270~zinc ion binding,GO:0016597~amino acid binding,GO:0016743~carboxyl- or carbamoyltransferase activity,GO:0016810~hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds,GO:0016812~hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides,GO:0019899~enzyme binding,GO:0042802~identical protein binding,GO:0046872~metal ion binding,GO:0070335~aspartate binding, IPR002082:Aspartate carbamoyltransferase,IPR002195:Dihydroorotase, conserved site,IPR002474:Carbamoyl-phosphate synthase, small subunit N-terminal domain,IPR005479:Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain,IPR005480:Carbamoyl-phosphate synthetase, large subunit oligomerisation domain,IPR005483:Carbamoyl-phosphate synthase large subunit, CPSase domain,IPR006130:Aspartate/ornithine carbamoyltransferase,IPR006131:Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain,IPR006132:Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding,IPR006274:Carbamoyl-phosphate synthase, small subunit,IPR006275:Carbamoyl-phosphate synthase, large subunit,IPR006680:Amidohydrolase 1,IPR011059:Metal-dependent hydrolase, composite domain,IPR011607:Methylglyoxal synthase-like domain,IPR011761:ATP-grasp fold,IPR013815:ATP-grasp fold, subdomain 1,IPR013816:ATP-grasp fold, subdomain 2,IPR016185:Pre-ATP-grasp domain,IPR017926:Glutamine amidotransferase, hsa00240:Pyrimidine metabolism,hsa00250:Alanine, aspartate and glutamate metabolism,hsa01100:Metabolic pathways, 616457~Congenital disorder of glycosylation, type Iz, SM00851:SM00851,SM01096:SM01096,SM01097:SM01097, 3D-structure,Acetylation,Allosteric enzyme,ATP-binding,Complete proteome,Congenital disorder of glycosylation,Cytoplasm,Direct protein sequencing,Disease mutation,Hydrolase,Ligase,Metal-binding,Multifunctional enzyme,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Pyrimidine biosynthesis,Reference proteome,Repeat,Transferase,Zinc, active site:For GATase activity,chain:CAD protein,domain:ATP-grasp 1,domain:ATP-grasp 2,domain:Glutamine amidotransferase type-1,metal ion-binding site:Zinc,modified residue,region of interest:ATCase (Aspartate transcarbamylase),region of interest:CPSase (Carbamoyl-phosphate synthase),region of interest:CPSase A,region of interest:CPSase B,region of interest:DHOase (dihydroorotase),region of interest:GATase (Glutamine amidotransferase),region of interest:Linker,sequence conflict,sequence variant, Q9NPF2 carbohydrate sulfotransferase 11(CHST11) Homo sapiens GO:0002063~chondrocyte development,GO:0007585~respiratory gaseous exchange,GO:0009791~post-embryonic development,GO:0016051~carbohydrate biosynthetic process,GO:0030206~chondroitin sulfate biosynthetic process,GO:0030512~negative regulation of transforming growth factor beta receptor signaling pathway,GO:0033037~polysaccharide localization,GO:0036342~post-anal tail morphogenesis,GO:0042127~regulation of cell proliferation,GO:0042733~embryonic digit morphogenesis,GO:0043066~negative regulation of apoptotic process,GO:0048589~developmental growth,GO:0048703~embryonic viscerocranium morphogenesis, GO:0000139~Golgi membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0001537~N-acetylgalactosamine 4-O-sulfotransferase activity,GO:0008146~sulfotransferase activity,GO:0047756~chondroitin 4-sulfotransferase activity,GO:0050659~N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity, IPR005331:Sulfotransferase,IPR018011:Carbohydrate sulfotransferase-related, hsa00532:Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, Alternative splicing,Carbohydrate metabolism,Chromosomal rearrangement,Complete proteome,Glycoprotein,Golgi apparatus,Membrane,Proteomics identification,Reference proteome,Signal-anchor,Transferase,Transmembrane,Transmembrane helix, chain:Carbohydrate sulfotransferase 11,glycosylation site:N-linked (GlcNAc...),mutagenesis site,nucleotide phosphate-binding region:PAPS,sequence conflict,splice variant,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, Q80UY1 carnosine N-methyltransferase 1(Carnmt1) Mus musculus GO:0032259~methylation,GO:0035498~carnosine metabolic process, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0008168~methyltransferase activity,GO:0016740~transferase activity,GO:0030735~carnosine N-methyltransferase activity, IPR012901:N2227-like, SM01296:SM01296, Complete proteome,Cytoplasm,Methyltransferase,Nucleus,Reference proteome,S-adenosyl-L-methionine,Transferase, chain:UPF0586 protein C9orf41 homolog,sequence conflict, P48729 casein kinase 1 alpha 1(CSNK1A1) Homo sapiens h_nfatPathway:NFAT and Hypertrophy of the heart (Transcription in the broken heart),h_p35AlzheimersPathway:Deregulation of CDK5 in Alzheimers Disease,h_p53hypoxiaPathway:Hypoxia and p53 in the Cardiovascular system,h_wntPathway:WNT Signaling Pathway, GO:0000902~cell morphogenesis,GO:0006468~protein phosphorylation,GO:0006909~phagocytosis,GO:0007030~Golgi organization,GO:0007067~mitotic nuclear division,GO:0007165~signal transduction,GO:0007166~cell surface receptor signaling pathway,GO:0008360~regulation of cell shape,GO:0016055~Wnt signaling pathway,GO:0018105~peptidyl-serine phosphorylation,GO:0032436~positive regulation of proteasomal ubiquitin-dependent protein catabolic process,GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process,GO:0045104~intermediate filament cytoskeleton organization,GO:0051301~cell division,GO:0090090~negative regulation of canonical Wnt signaling pathway,GO:1904424~regulation of GTP binding,GO:1904885~beta-catenin destruction complex assembly,GO:1904886~beta-catenin destruction complex disassembly, GO:0000777~condensed chromosome kinetochore,GO:0005813~centrosome,GO:0005829~cytosol,GO:0005847~mRNA cleavage and polyadenylation specificity factor complex,GO:0016020~membrane,GO:0016607~nuclear speck,GO:0030529~intracellular ribonucleoprotein complex,GO:0030877~beta-catenin destruction complex,GO:0045095~keratin filament,GO:0072372~primary cilium, GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016301~kinase activity, IPR000719:Protein kinase, catalytic domain,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, hsa04310:Wnt signaling pathway,hsa04340:Hedgehog signaling pathway, SM00220:S_TKc, 3D-structure,Acetylation,Alternative splicing,ATP-binding,Cell cycle,Cell division,Centromere,Chromosome,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Kinase,Kinetochore,Mitosis,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Serine/threonine-protein kinase,Transferase,Wnt signaling pathway, active site:Proton acceptor,binding site:ATP,chain:Casein kinase I isoform alpha,domain:Protein kinase,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,sequence variant,splice variant, Q06486 casein kinase 1, delta(Csnk1d) Rattus norvegicus GO:0001934~positive regulation of protein phosphorylation,GO:0006468~protein phosphorylation,GO:0006897~endocytosis,GO:0007020~microtubule nucleation,GO:0007030~Golgi organization,GO:0008360~regulation of cell shape,GO:0016055~Wnt signaling pathway,GO:0018105~peptidyl-serine phosphorylation,GO:0030177~positive regulation of Wnt signaling pathway,GO:0032436~positive regulation of proteasomal ubiquitin-dependent protein catabolic process,GO:0032922~circadian regulation of gene expression,GO:0034067~protein localization to Golgi apparatus,GO:0035058~nonmotile primary cilium assembly,GO:0042752~regulation of circadian rhythm,GO:0051225~spindle assembly,GO:0061512~protein localization to cilium,GO:0071539~protein localization to centrosome,GO:0090263~positive regulation of canonical Wnt signaling pathway,GO:0098609~cell-cell adhesion,GO:1990090~cellular response to nerve growth factor stimulus,GO:2000052~positive regulation of non-canonical Wnt signaling pathway, GO:0005634~nucleus,GO:0005794~Golgi apparatus,GO:0005813~centrosome,GO:0005819~spindle,GO:0005876~spindle microtubule,GO:0005886~plasma membrane,GO:0005913~cell-cell adherens junction,GO:0043005~neuron projection,GO:0048471~perinuclear region of cytoplasm, GO:0001948~glycoprotein binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0042277~peptide binding,GO:0050321~tau-protein kinase activity,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000719:Protein kinase, catalytic domain,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, rno04340:Hedgehog signaling pathway,rno04390:Hippo signaling pathway,rno04540:Gap junction,rno04710:Circadian rhythm, SM00220:S_TKc, 3D-structure,Alternative splicing,ATP-binding,Biological rhythms,Cell membrane,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Golgi apparatus,Kinase,Membrane,Methylation,Nucleotide-binding,Nucleus,Phosphoprotein,Reference proteome,Serine/threonine-protein kinase,Transferase,Wnt signaling pathway, active site:Proton acceptor,binding site:ATP,chain:Casein kinase I isoform delta,domain:Protein kinase,helix,modified residue,nucleotide phosphate-binding region:ATP,region of interest:Autoinhibitory,splice variant,strand,turn, P28020 casein kinase 2, alpha 1 polypeptide S homeolog(csnk2a1.S) Xenopus laevis GO:0016055~Wnt signaling pathway, GO:0005634~nucleus, GO:0004674~protein serine/threonine kinase activity,GO:0005524~ATP binding, IPR000719:Protein kinase, catalytic domain,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, xla03008:Ribosome biogenesis in eukaryotes,xla04310:Wnt signaling pathway,xla04520:Adherens junction,xla05168:Herpes simplex infection, SM00220:S_TKc, ATP-binding,Kinase,Nucleotide-binding,Nucleus,Serine/threonine-protein kinase,Transferase,Wnt signaling pathway, active site:Proton acceptor,binding site:ATP,chain:Casein kinase II subunit alpha,domain:Protein kinase,nucleotide phosphate-binding region:ATP, P42575 caspase 2(CASP2) Homo sapiens h_caspasePathway:Caspase Cascade in Apoptosis,h_hivnefPathway:HIV-I Nef: negative effector of Fas and TNF,h_stressPathway:TNF/Stress Related Signaling,h_tnfr1Pathway:TNFR1 Signaling Pathway, GO:0001554~luteolysis,GO:0003407~neural retina development,GO:0006915~apoptotic process,GO:0006919~activation of cysteine-type endopeptidase activity involved in apoptotic process,GO:0006977~DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,GO:0007420~brain development,GO:0007568~aging,GO:0008630~intrinsic apoptotic signaling pathway in response to DNA damage,GO:0016485~protein processing,GO:0035234~ectopic germ cell programmed cell death,GO:0042981~regulation of apoptotic process,GO:0043065~positive regulation of apoptotic process,GO:0043525~positive regulation of neuron apoptotic process,GO:0071260~cellular response to mechanical stimulus,GO:0097190~apoptotic signaling pathway,GO:0097192~extrinsic apoptotic signaling pathway in absence of ligand,GO:0097194~execution phase of apoptosis,GO:2001235~positive regulation of apoptotic signaling pathway, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0005829~cytosol,GO:0016020~membrane, GO:0004197~cysteine-type endopeptidase activity,GO:0005515~protein binding,GO:0019899~enzyme binding,GO:0019904~protein domain specific binding,GO:0042802~identical protein binding,GO:0097153~cysteine-type endopeptidase activity involved in apoptotic process, IPR001309:Peptidase C14, ICE, catalytic subunit p20,IPR001315:Caspase Recruitment,IPR002138:Peptidase C14, caspase non-catalytic subunit p10,IPR011029:Death-like domain,IPR015917:Peptidase C14, caspase precursor p45, core,IPR016129:Peptidase C14, ICE, catalytic subunit p20, active site,IPR017350:Caspase, interleukin-1 beta convertase, PIRSF038001:caspase, interleukin-1 beta convertase type, SM00114:CARD,SM00115:CASc, 3D-structure,Acetylation,Alternative splicing,Apoptosis,Complete proteome,Hydrolase,Phosphoprotein,Polymorphism,Protease,Proteomics identification,Reference proteome,Thiol protease,Zymogen, chain:Caspase-2 subunit p12,chain:Caspase-2 subunit p13,chain:Caspase-2 subunit p18,domain:CARD,helix,modified residue,mutagenesis site,sequence conflict,sequence variant,splice variant,strand,turn, Q99KF0 caspase recruitment domain family, member 14(Card14) Mus musculus GO:0001934~positive regulation of protein phosphorylation,GO:0006915~apoptotic process,GO:0033209~tumor necrosis factor-mediated signaling pathway,GO:0042981~regulation of apoptotic process,GO:0043066~negative regulation of apoptotic process,GO:0051092~positive regulation of NF-kappaB transcription factor activity, GO:0005737~cytoplasm, GO:0050700~CARD domain binding, IPR001315:Caspase Recruitment,IPR001478:PDZ domain,IPR008144:Guanylate kinase,IPR011029:Death-like domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00228:PDZ, Apoptosis,Coiled coil,Complete proteome,Cytoplasm,Phosphoprotein,Reference proteome, chain:Caspase recruitment domain-containing protein 14,domain:CARD,domain:Guanylate kinase-like,domain:PDZ,modified residue,sequence conflict, A2AIV8 caspase recruitment domain family, member 9(Card9) Mus musculus GO:0002376~immune system process,GO:0007249~I-kappaB kinase/NF-kappaB signaling,GO:0009620~response to fungus,GO:0032494~response to peptidoglycan,GO:0032495~response to muramyl dipeptide,GO:0032755~positive regulation of interleukin-6 production,GO:0032760~positive regulation of tumor necrosis factor production,GO:0032874~positive regulation of stress-activated MAPK cascade,GO:0042493~response to drug,GO:0042534~regulation of tumor necrosis factor biosynthetic process,GO:0042981~regulation of apoptotic process,GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling,GO:0043330~response to exogenous dsRNA,GO:0045076~regulation of interleukin-2 biosynthetic process,GO:0045087~innate immune response,GO:0045089~positive regulation of innate immune response,GO:0045408~regulation of interleukin-6 biosynthetic process,GO:0046330~positive regulation of JNK cascade,GO:0050830~defense response to Gram-positive bacterium,GO:0051092~positive regulation of NF-kappaB transcription factor activity,GO:0051607~defense response to virus,GO:0070423~nucleotide-binding oligomerization domain containing signaling pathway, GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0005515~protein binding,GO:0019904~protein domain specific binding,GO:0042803~protein homodimerization activity,GO:0050700~CARD domain binding, IPR001315:Caspase Recruitment,IPR011029:Death-like domain, mmu04621:NOD-like receptor signaling pathway,mmu05152:Tuberculosis, Coiled coil,Complete proteome,Cytoplasm,Immunity,Innate immunity,Phosphoprotein,Reference proteome, O75419 cell division cycle 45(CDC45) Homo sapiens GO:0000076~DNA replication checkpoint,GO:0000082~G1/S transition of mitotic cell cycle,GO:0000083~regulation of transcription involved in G1/S transition of mitotic cell cycle,GO:0000727~double-strand break repair via break-induced replication,GO:0006260~DNA replication,GO:0006267~pre-replicative complex assembly involved in nuclear cell cycle DNA replication,GO:0006270~DNA replication initiation,GO:0031938~regulation of chromatin silencing at telomere,GO:0032508~DNA duplex unwinding,GO:1900087~positive regulation of G1/S transition of mitotic cell cycle,GO:1902977~mitotic DNA replication preinitiation complex assembly, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005656~nuclear pre-replicative complex,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0031261~DNA replication preinitiation complex,GO:0031298~replication fork protection complex, GO:0003682~chromatin binding,GO:0003688~DNA replication origin binding,GO:0003697~single-stranded DNA binding,GO:0005515~protein binding,GO:0043138~3'-5' DNA helicase activity, IPR003874:CDC45 family, hsa04110:Cell cycle, 3D-structure,Alternative splicing,Cell cycle,Complete proteome,Cytoplasm,DNA replication,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Signal, chain:CDC45-related protein,modified residue,sequence conflict,sequence variant, Q99618 cell division cycle associated 3(CDCA3) Homo sapiens GO:0007067~mitotic nuclear division,GO:0016567~protein ubiquitination,GO:0051301~cell division, GO:0005829~cytosol,GO:0005911~cell-cell junction, GO:0005515~protein binding, Cell cycle,Cell division,Complete proteome,Cytoplasm,Mitosis,Phosphoprotein,Proteomics identification,Reference proteome,Ubl conjugation,Ubl conjugation pathway, chain:Cell division cycle-associated protein 3,modified residue,region of interest:F-box-like,short sequence motif:KEN box, Q5XLR4 cell division cycle associated 8(cdca8) Danio rerio GO:0000070~mitotic sister chromatid segregation,GO:0007049~cell cycle,GO:0007067~mitotic nuclear division,GO:0007507~heart development,GO:0051301~cell division, GO:0000775~chromosome, centromeric region,GO:0005634~nucleus,GO:0005694~chromosome,GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0032133~chromosome passenger complex,GO:0051233~spindle midzone, IPR018851:Borealin-like, N-terminal,IPR018867:Cell division protein borealin, Cell cycle,Cell division,Centromere,Chromosome,Complete proteome,Cytoplasm,Cytoskeleton,Mitosis,Nucleus,Proteomics identification,Reference proteome, chain:Borealin,sequence conflict, P23504 cell surface antigen SpaP(spaP) Streptococcus mutans UA159 GO:0005576~extracellular region,GO:0005618~cell wall, IPR009578:Surface antigen, Streptococcal,IPR013574:Glucan-binding protein C/Surface antigen I/II, V-domain,IPR019948:Gram-positive anchor,IPR021197:Cross-wall-targeting lipoprotein motif,IPR026345:Adhesin isopeptide-forming adherence domain, Cell wall,Complete proteome,Dental caries,Direct protein sequencing,Peptidoglycan-anchor,Reference proteome,Repeat,Secreted,Signal, chain:Cell surface antigen I,chain:Cell surface antigen II,modified residue,propeptide:Removed by sortase,region of interest:3 X tandem repeats, Ala-rich,region of interest:3 X tandem repeats, Pro-rich,region of interest:Helical,sequence conflict,short sequence motif:LPXTG sorting signal,signal peptide, O43303 centriolar coiled-coil protein 110(CCP110) Homo sapiens GO:0000086~G2/M transition of mitotic cell cycle,GO:0007099~centriole replication,GO:0032053~ciliary basal body organization,GO:0032465~regulation of cytokinesis,GO:0045724~positive regulation of cilium assembly,GO:0051298~centrosome duplication,GO:1902018~negative regulation of cilium assembly, GO:0005813~centrosome,GO:0005814~centriole,GO:0005829~cytosol,GO:0005929~cilium,GO:0043234~protein complex, GO:0005515~protein binding, Alternative splicing,Cell projection,Cilium,Cilium biogenesis/degradation,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Ubl conjugation, chain:Centrosomal protein of 110 kDa,modified residue,region of interest:Calmodulin-binding,region of interest:CEP97 binding,region of interest:Interaction with CEP76,sequence conflict,sequence variant,splice variant, Q8N8E3 centrosomal protein 112(CEP112) Homo sapiens Cell division and chromosome partitioning, GO:0097120~receptor localization to synapse, GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005886~plasma membrane,GO:0060077~inhibitory synapse, Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Polymorphism,Proteomics identification,Reference proteome, chain:Coiled-coil domain-containing protein 46,sequence conflict,sequence variant,splice variant, U3JAG9 centrosomal protein 131(cep131) Danio rerio GO:0006810~transport,GO:0010824~regulation of centrosome duplication,GO:0030030~cell projection organization,GO:0030154~cell differentiation,GO:0032402~melanosome transport,GO:0035721~intraciliary retrograde transport,GO:0035735~intraciliary transport involved in cilium morphogenesis,GO:0050953~sensory perception of light stimulus,GO:0060271~cilium morphogenesis,GO:0060287~epithelial cilium movement involved in determination of left/right asymmetry,GO:0070121~Kupffer's vesicle development,GO:0090317~negative regulation of intracellular protein transport, GO:0000775~chromosome, centromeric region,GO:0005694~chromosome,GO:0005929~cilium,GO:0034451~centriolar satellite, Centromere,Chromosome,Cilium biogenesis/degradation,Coiled coil,Complete proteome,Differentiation,Proteomics identification,Reference proteome,Transport, Q28FA8 centrosomal protein 41kDa(cep41) Xenopus tropicalis GO:0015031~protein transport,GO:0016337~single organismal cell-cell adhesion,GO:0018095~protein polyglutamylation,GO:0042384~cilium assembly, GO:0005814~centriole,GO:0005886~plasma membrane,GO:0005911~cell-cell junction,GO:0009986~cell surface,GO:0036064~ciliary basal body,GO:0072372~primary cilium, IPR001763:Rhodanese-like domain, SM00450:RHOD, Cell projection,Ciliopathy,Cilium,Cilium biogenesis/degradation,Complete proteome,Cytoplasm,Cytoskeleton,Protein transport,Reference proteome,Transport, Q5JTW2 centrosomal protein 78(CEP78) Homo sapiens GO:0000086~G2/M transition of mitotic cell cycle, GO:0005813~centrosome,GO:0005829~cytosol, IPR001611:Leucine-rich repeat,IPR026212:Centrosomal protein of 78kDa, Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Phosphoprotein,Proteomics identification,Reference proteome, chain:Centrosomal protein of 78 kDa,modified residue,repeat:LRR 1,repeat:LRR 2,repeat:LRR 3,sequence conflict,splice variant, Q6DBQ8 ceramide-1-phosphate transfer protein(cptp) Danio rerio GO:0006810~transport,GO:0006869~lipid transport,GO:0046836~glycolipid transport,GO:1902389~ceramide 1-phosphate transport, GO:0005634~nucleus,GO:0005640~nuclear outer membrane,GO:0005737~cytoplasm,GO:0005768~endosome,GO:0005794~Golgi apparatus,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0010008~endosome membrane,GO:0016020~membrane, GO:0005543~phospholipid binding,GO:0005548~phospholipid transporter activity,GO:0008289~lipid binding,GO:0017089~glycolipid transporter activity,GO:0051861~glycolipid binding,GO:1902387~ceramide 1-phosphate binding,GO:1902388~ceramide 1-phosphate transporter activity, IPR014830:Glycolipid transfer protein domain, Cell membrane,Complete proteome,Cytoplasm,Endosome,Golgi apparatus,Lipid transport,Lipid-binding,Membrane,Nucleus,Reference proteome,Transport, chain:Glycolipid transfer protein domain- containing protein 1, P63182 cerebellin 1 precursor(Cbln1) Rattus norvegicus GO:0007157~heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,GO:0009306~protein secretion,GO:0021707~cerebellar granule cell differentiation,GO:0051965~positive regulation of synapse assembly, GO:0005576~extracellular region,GO:0030054~cell junction,GO:0045202~synapse,GO:0045211~postsynaptic membrane, GO:0042803~protein homodimerization activity, IPR001073:Complement C1q protein,IPR008983:Tumour necrosis factor-like domain, SM00110:C1Q, 3D-structure,Cell junction,Cell membrane,Complete proteome,Direct protein sequencing,Disulfide bond,Glycoprotein,Membrane,Postsynaptic cell membrane,Reference proteome,Secreted,Signal,Synapse, chain:Cerebellin-1,disulfide bond,domain:C1q,glycosylation site:N-linked (GlcNAc...),peptide:[des-Ser1]-cerebellin,peptide:Cerebellin,region of interest:Necessary for interaction with CBLN3, and homotrimerization,signal peptide, Q5ZJK8 chaperonin containing TCP1 subunit 7(CCT7) Gallus gallus GO:0006457~protein folding,GO:0007339~binding of sperm to zona pellucida,GO:0032212~positive regulation of telomere maintenance via telomerase,GO:0050821~protein stabilization,GO:1901998~toxin transport,GO:1904851~positive regulation of establishment of protein localization to telomere,GO:1904871~positive regulation of protein localization to Cajal body,GO:1904874~positive regulation of telomerase RNA localization to Cajal body, GO:0002199~zona pellucida receptor complex,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0005832~chaperonin-containing T-complex,GO:0005874~microtubule,GO:0044297~cell body,GO:0070062~extracellular exosome, GO:0005524~ATP binding,GO:0051082~unfolded protein binding, IPR002194:Chaperonin TCP-1, conserved site,IPR002423:Chaperonin Cpn60/TCP-1,IPR012720:T-complex protein 1, eta subunit,IPR017998:Chaperone tailless complex polypeptide 1 (TCP-1),IPR027409:GroEL-like apical domain,IPR027410:TCP-1-like chaperonin intermediate domain,IPR027413:GroEL-like equatorial domain, ATP-binding,Chaperone,Complete proteome,Cytoplasm,Nucleotide-binding,Reference proteome, chain:T-complex protein 1 subunit eta, Q8CGS4 charged multivesicular body protein 3(Chmp3) Rattus norvegicus GO:0000920~cell separation after cytokinesis,GO:0006997~nucleus organization,GO:0007049~cell cycle,GO:0007080~mitotic metaphase plate congression,GO:0008333~endosome to lysosome transport,GO:0010824~regulation of centrosome duplication,GO:0015031~protein transport,GO:0032467~positive regulation of cytokinesis,GO:0039702~viral budding via host ESCRT complex,GO:0050792~regulation of viral process,GO:0051036~regulation of endosome size,GO:0051258~protein polymerization,GO:0051291~protein heterooligomerization,GO:0051301~cell division,GO:1901673~regulation of mitotic spindle assembly,GO:1902187~negative regulation of viral release from host cell,GO:1902188~positive regulation of viral release from host cell,GO:1903541~regulation of exosomal secretion, GO:0000815~ESCRT III complex,GO:0005769~early endosome,GO:0005770~late endosome,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0030496~midbody,GO:0031410~cytoplasmic vesicle,GO:0031902~late endosome membrane,GO:0070062~extracellular exosome, GO:0005546~phosphatidylinositol-4,5-bisphosphate binding,GO:0031210~phosphatidylcholine binding,GO:0042803~protein homodimerization activity,GO:1990381~ubiquitin-specific protease binding, IPR005024:Snf7, rno04144:Endocytosis, Cell cycle,Cell division,Coiled coil,Complete proteome,Cytoplasm,Endosome,Isopeptide bond,Lipoprotein,Membrane,Myristate,Phosphoprotein,Protein transport,Reference proteome,Transport,Ubl conjugation, chain:Charged multivesicular body protein 3,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),lipid moiety-binding region:N-myristoyl glycine,modified residue,mutagenesis site,region of interest:Interaction with STAMBP,region of interest:Interaction with VPS4A,region of interest:Intramolecular interaction with C- terminus,region of interest:Intramolecular interaction with N- terminus,short sequence motif:MIT-interacting motif, Q9Z265 checkpoint kinase 2(Chek2) Mus musculus m_atmPathway:ATM Signaling Pathway,m_atrbrcaPathway:Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, GO:0000077~DNA damage checkpoint,GO:0000085~mitotic G2 phase,GO:0000086~G2/M transition of mitotic cell cycle,GO:0001302~replicative cell aging,GO:0001934~positive regulation of protein phosphorylation,GO:0006281~DNA repair,GO:0006302~double-strand break repair,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006468~protein phosphorylation,GO:0006915~apoptotic process,GO:0006974~cellular response to DNA damage stimulus,GO:0006975~DNA damage induced protein phosphorylation,GO:0006978~DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,GO:0007049~cell cycle,GO:0007067~mitotic nuclear division,GO:0008630~intrinsic apoptotic signaling pathway in response to DNA damage,GO:0010332~response to gamma radiation,GO:0016310~phosphorylation,GO:0018105~peptidyl-serine phosphorylation,GO:0035690~cellular response to drug,GO:0042176~regulation of protein catabolic process,GO:0042770~signal transduction in response to DNA damage,GO:0042771~intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator,GO:0044257~cellular protein catabolic process,GO:0045893~positive regulation of transcription, DNA-templated,GO:0046777~protein autophosphorylation,GO:0050821~protein stabilization,GO:0051301~cell division,GO:0071157~negative regulation of cell cycle arrest,GO:0071480~cellular response to gamma radiation,GO:0072428~signal transduction involved in intra-S DNA damage checkpoint,GO:0090307~mitotic spindle assembly,GO:1903926~cellular response to bisphenol A,GO:2000002~negative regulation of DNA damage checkpoint,GO:2000210~positive regulation of anoikis, GO:0000781~chromosome, telomeric region,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005794~Golgi apparatus,GO:0016605~PML body, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0016740~transferase activity,GO:0019901~protein kinase binding,GO:0031625~ubiquitin protein ligase binding,GO:0042802~identical protein binding,GO:0042803~protein homodimerization activity,GO:0046872~metal ion binding, IPR000253:Forkhead-associated (FHA) domain,IPR000719:Protein kinase, catalytic domain,IPR008271:Serine/threonine-protein kinase, active site,IPR008984:SMAD/FHA domain,IPR011009:Protein kinase-like domain,IPR020636:Calcium/calmodulin-dependent/calcium-dependent protein kinase, mmu04110:Cell cycle,mmu04115:p53 signaling pathway,mmu05166:HTLV-I infection, SM00220:S_TKc,SM00240:FHA, Apoptosis,ATP-binding,Cell cycle,Cell division,Complete proteome,DNA damage,DNA repair,Kinase,Magnesium,Metal-binding,Mitosis,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Serine/threonine-protein kinase,Transcription,Transcription regulation,Transferase,Ubl conjugation, active site:Proton acceptor,binding site:ATP,chain:Serine/threonine-protein kinase Chk2,domain:FHA,domain:Protein kinase,modified residue,nucleotide phosphate-binding region:ATP, Q9VEN1 cheerio(cher) Drosophila melanogaster GO:0007067~mitotic nuclear division,GO:0007301~female germline ring canal formation,GO:0007303~cytoplasmic transport, nurse cell to oocyte,GO:0007611~learning or memory,GO:0007616~long-term memory,GO:0008045~motor neuron axon guidance,GO:0008104~protein localization,GO:0008302~female germline ring canal formation, actin assembly,GO:0008340~determination of adult lifespan,GO:0008355~olfactory learning,GO:0030431~sleep,GO:0030708~germarium-derived female germ-line cyst encapsulation,GO:0030725~germline ring canal formation,GO:0035204~negative regulation of lamellocyte differentiation,GO:0048149~behavioral response to ethanol,GO:0051495~positive regulation of cytoskeleton organization, GO:0005634~nucleus,GO:0005829~cytosol,GO:0005884~actin filament,GO:0005886~plasma membrane,GO:0015629~actin cytoskeleton,GO:0035182~female germline ring canal outer rim,GO:0035183~female germline ring canal inner rim,GO:0035324~female germline ring canal,GO:0045179~apical cortex,GO:0048471~perinuclear region of cytoplasm,GO:0070938~contractile ring, GO:0003779~actin binding,GO:0051015~actin filament binding, IPR001298:Filamin/ABP280 repeat,IPR001589:Actinin-type, actin-binding, conserved site,IPR001715:Calponin homology domain,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR017868:Filamin/ABP280 repeat-like, SM00033:CH,SM00557:IG_FLMN, Actin-binding,Alternative splicing,Cell membrane,Complete proteome,Cytoplasm,Cytoskeleton,Membrane,Proteomics identification,Reference proteome,Repeat, O70496 chloride channel, voltage-sensitive 7(Clcn7) Mus musculus GO:0006810~transport,GO:0006811~ion transport,GO:0006821~chloride transport,GO:0009268~response to pH,GO:0055085~transmembrane transport,GO:1902476~chloride transmembrane transport, GO:0005764~lysosome,GO:0005765~lysosomal membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0031410~cytoplasmic vesicle, GO:0000166~nucleotide binding,GO:0005216~ion channel activity,GO:0005247~voltage-gated chloride channel activity,GO:0005524~ATP binding,GO:0015297~antiporter activity,GO:0031404~chloride ion binding, IPR000644:Cystathionine beta-synthase, core,IPR001807:Chloride channel, voltage gated,IPR002249:Chloride channel ClC-7,IPR014743:Chloride channel, core, SM00116:CBS, Antiport,ATP-binding,CBS domain,Chloride,Complete proteome,Ion transport,Lysosome,Membrane,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Transport, binding site:Chloride,binding site:Chloride; via amide nitrogen,chain:H(+)/Cl(-) exchange transporter 7,domain:CBS 1,domain:CBS 2,modified residue,nucleotide phosphate-binding region:ATP,region of interest:In-membrane helix,region of interest:In-membrane loop between two helices,short sequence motif:Selectivity filter part_1,short sequence motif:Selectivity filter part_2,short sequence motif:Selectivity filter part_3,site:Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport,site:Mediates proton transfer from the protein to the inner aqueous phase,topological domain:Cytoplasmic,transmembrane region, Q8BJ64 choline dehydrogenase(Chdh) Mus musculus GO:0019285~glycine betaine biosynthetic process from choline,GO:0055114~oxidation-reduction process, GO:0005739~mitochondrion,GO:0005743~mitochondrial inner membrane,GO:0016020~membrane, GO:0008812~choline dehydrogenase activity,GO:0016491~oxidoreductase activity,GO:0016614~oxidoreductase activity, acting on CH-OH group of donors,GO:0050660~flavin adenine dinucleotide binding, IPR000172:Glucose-methanol-choline oxidoreductase, N-terminal,IPR007867:Glucose-methanol-choline oxidoreductase, C-terminal,IPR011533:Choline dehydrogenase,IPR012132:Glucose-methanol-choline oxidoreductase,IPR023753:Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain, mmu00260:Glycine, serine and threonine metabolism,mmu01100:Metabolic pathways, PIRSF000137:glucose-methanol-choline oxidoreductase, Acetylation,Complete proteome,FAD,Flavoprotein,Membrane,Mitochondrion,Mitochondrion inner membrane,Oxidoreductase,Reference proteome,Signal,Transit peptide, chain:Choline dehydrogenase, mitochondrial,modified residue,nucleotide phosphate-binding region:FAD,sequence conflict,transit peptide:Mitochondrion, Q86WJ1 chromodomain helicase DNA binding protein 1 like(CHD1L) Homo sapiens GO:0000717~nucleotide-excision repair, DNA duplex unwinding,GO:0006281~DNA repair,GO:0006293~nucleotide-excision repair, preincision complex stabilization,GO:0006294~nucleotide-excision repair, preincision complex assembly,GO:0006295~nucleotide-excision repair, DNA incision, 3'-to lesion,GO:0006296~nucleotide-excision repair, DNA incision, 5'-to lesion,GO:0006338~chromatin remodeling,GO:0006974~cellular response to DNA damage stimulus,GO:0033683~nucleotide-excision repair, DNA incision,GO:0070911~global genome nucleotide-excision repair, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005886~plasma membrane, GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0004003~ATP-dependent DNA helicase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008026~ATP-dependent helicase activity,GO:0016887~ATPase activity, IPR000330:SNF2-related,IPR001650:Helicase, C-terminal,IPR002464:DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site,IPR002589:Appr-1-p processing,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00487:DEXDc,SM00490:HELICc, Alternative splicing,ATP-binding,Coiled coil,Complete proteome,DNA damage,DNA repair,Helicase,Hydrolase,Methylation,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:Chromodomain-helicase-DNA-binding protein 1-like,domain:Helicase ATP-binding,domain:Helicase C-terminal,domain:Macro,modified residue,mutagenesis site,nucleotide phosphate-binding region:ATP,sequence conflict,sequence variant,short sequence motif:DEAH box,splice variant, Q14839 chromodomain helicase DNA binding protein 4(CHD4) Homo sapiens GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0006325~chromatin organization,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0016575~histone deacetylation,GO:0032508~DNA duplex unwinding,GO:0043044~ATP-dependent chromatin remodeling,GO:0051225~spindle assembly,GO:0072553~terminal button organization,GO:1901796~regulation of signal transduction by p53 class mediator, GO:0000790~nuclear chromatin,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0016020~membrane,GO:0016581~NuRD complex,GO:0032993~protein-DNA complex,GO:0043234~protein complex, GO:0000978~RNA polymerase II core promoter proximal region sequence-specific DNA binding,GO:0000980~RNA polymerase II distal enhancer sequence-specific DNA binding,GO:0001103~RNA polymerase II repressing transcription factor binding,GO:0003677~DNA binding,GO:0004003~ATP-dependent DNA helicase activity,GO:0004407~histone deacetylase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008017~microtubule binding,GO:0008026~ATP-dependent helicase activity,GO:0008270~zinc ion binding,GO:0016818~hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides,GO:0031492~nucleosomal DNA binding, IPR000330:SNF2-related,IPR000953:Chromo domain/shadow,IPR001650:Helicase, C-terminal,IPR001965:Zinc finger, PHD-type,IPR002464:DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site,IPR009462:Domain of unknown function DUF1086,IPR009463:Domain of unknown function DUF1087,IPR011011:Zinc finger, FYVE/PHD-type,IPR012957:CHD, C-terminal 2,IPR012958:CHD, N-terminal,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR016197:Chromo domain-like,IPR019786:Zinc finger, PHD-type, conserved site,IPR019787:Zinc finger, PHD-finger,IPR023780:Chromo domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa05203:Viral carcinogenesis, SM00249:PHD,SM00298:CHROMO,SM00487:DEXDc,SM00490:HELICc,SM01146:SM01146,SM01147:SM01147, 3D-structure,Acetylation,Alternative splicing,ATP-binding,Chromatin regulator,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,DNA-binding,Helicase,Hydrolase,Isopeptide bond,Metal-binding,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,Ubl conjugation,Zinc,Zinc-finger, chain:Chromodomain-helicase-DNA-binding protein 4,compositionally biased region:Poly-Ala,compositionally biased region:Poly-Asp,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Leu,compositionally biased region:Poly-Lys,compositionally biased region:Poly-Pro,domain:Chromo 1,domain:Chromo 2,domain:Helicase ATP-binding,domain:Helicase C-terminal,helix,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,sequence variant,short sequence motif:DEAH box,splice variant,strand,turn,zinc finger region:PHD-type 1,zinc finger region:PHD-type 2, Q8AY73 chromosome segregation 1 like(cse1l) Oreochromis niloticus GO:0006886~intracellular protein transport,GO:0007589~body fluid secretion, GO:0005634~nucleus,GO:0005737~cytoplasm, IPR001494:Importin-beta, N-terminal,IPR005043:CAS/CSE, C-terminal,IPR011989:Armadillo-like helical,IPR013713:Exportin/Importin, Cse1-like,IPR016024:Armadillo-type fold, SM00913:SM00913, Complete proteome,Cytoplasm,Nucleus,Protein transport,Reference proteome,Transport, B5X5D0 chromosome ssa24 open reading frame, human C9orf116(cssa24h9orf116) Salmo salar IPR026507:Uncharacterised protein family UPF0691, chain:UPF0691 protein C9orf116 homolog, Q96N23 cilia and flagella associated protein 54(CFAP54) Homo sapiens GO:0007283~spermatogenesis,GO:0030154~cell differentiation,GO:0042384~cilium assembly,GO:0060271~cilium morphogenesis,GO:0060294~cilium movement involved in cell motility, GO:0005737~cytoplasm,GO:0005930~axoneme,GO:0016021~integral component of membrane, IPR011990:Tetratricopeptide-like helical, Alternative splicing,Cell projection,Cilium,Cilium biogenesis/degradation,Complete proteome,Cytoplasm,Cytoskeleton,Differentiation,Membrane,Polymorphism,Proteomics identification,Reference proteome,Spermatogenesis,Transmembrane,Transmembrane helix, chain:Uncharacterized protein C12orf55,sequence variant, Q5TZA2 ciliary rootlet coiled-coil, rootletin(CROCC) Homo sapiens GO:0007049~cell cycle,GO:0008104~protein localization,GO:0010457~centriole-centriole cohesion,GO:0010669~epithelial structure maintenance,GO:0032053~ciliary basal body organization,GO:0033365~protein localization to organelle,GO:0045494~photoreceptor cell maintenance,GO:0051297~centrosome organization,GO:0051656~establishment of organelle localization, GO:0001917~photoreceptor inner segment,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005814~centriole,GO:0005886~plasma membrane,GO:0015629~actin cytoskeleton,GO:0035253~ciliary rootlet,GO:0070062~extracellular exosome, GO:0003779~actin binding,GO:0005198~structural molecule activity,GO:0005515~protein binding,GO:0019894~kinesin binding, IPR026733:Rootletin, Alternative splicing,Cell cycle,Cilium biogenesis/degradation,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:Rootletin,compositionally biased region:Gln-rich,modified residue,sequence variant,splice variant, Q8CJ40 ciliary rootlet coiled-coil, rootletin(Crocc) Mus musculus GO:0007049~cell cycle,GO:0008104~protein localization,GO:0010457~centriole-centriole cohesion,GO:0010669~epithelial structure maintenance,GO:0030030~cell projection organization,GO:0032053~ciliary basal body organization,GO:0033365~protein localization to organelle,GO:0045494~photoreceptor cell maintenance,GO:0051297~centrosome organization,GO:0051656~establishment of organelle localization, GO:0001917~photoreceptor inner segment,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005814~centriole,GO:0005856~cytoskeleton,GO:0005886~plasma membrane,GO:0015629~actin cytoskeleton,GO:0035253~ciliary rootlet,GO:0070062~extracellular exosome, GO:0003779~actin binding,GO:0005198~structural molecule activity,GO:0005515~protein binding,GO:0019894~kinesin binding, IPR026733:Rootletin, Alternative splicing,Cell cycle,Cilium biogenesis/degradation,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Phosphoprotein,Proteomics identification,Reference proteome, chain:Rootletin,modified residue,sequence conflict,splice variant, Q5I0K3 citrate lyase beta like(Clybl) Rattus norvegicus GO:0005739~mitochondrion, GO:0000287~magnesium ion binding,GO:0004474~malate synthase activity, IPR005000:Aldehyde-lyase domain,IPR011206:Citrate lyase, beta subunit,IPR015813:Pyruvate/Phosphoenolpyruvate kinase-like domain, PIRSF015582:citrate lyase, beta subunit, Acetylation,Alternative splicing,Complete proteome,Magnesium,Metal-binding,Mitochondrion,Reference proteome,Transferase,Transit peptide, binding site:Substrate,chain:Citrate lyase subunit beta-like protein, mitochondrial,metal ion-binding site:Magnesium,splice variant,transit peptide:Mitochondrion, Q9U1M8 class VII unconventional myosin(myoI) Dictyostelium discoideum AX4 GO:0000902~cell morphogenesis,GO:0006909~phagocytosis,GO:0009847~spore germination,GO:0030048~actin filament-based movement,GO:0031589~cell-substrate adhesion,GO:0046847~filopodium assembly, GO:0001891~phagocytic cup,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005856~cytoskeleton,GO:0016020~membrane,GO:0016459~myosin complex,GO:0030175~filopodium,GO:0031252~cell leading edge, GO:0000166~nucleotide binding,GO:0003774~motor activity,GO:0003779~actin binding,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008017~microtubule binding,GO:0030898~actin-dependent ATPase activity,GO:0043621~protein self-association,GO:0051015~actin filament binding, IPR000048:IQ motif, EF-hand binding site,IPR000299:FERM domain,IPR000857:MyTH4 domain,IPR001452:Src homology-3 domain,IPR001609:Myosin head, motor domain,IPR011511:Variant SH3,IPR011993:Pleckstrin homology-like domain,IPR019748:FERM central domain,IPR019749:Band 4.1 domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00015:IQ,SM00139:MyTH4,SM00242:MYSc,SM00295:B41,SM00326:SH3, 3D-structure,Actin-binding,ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Motor protein,Myosin,Nucleotide-binding,Reference proteome,Repeat,SH3 domain, O08585 clathrin, light polypeptide (Lca)(Clta) Mus musculus m_arapPathway:ADP-Ribosylation Factor, GO:0006886~intracellular protein transport,GO:0006897~endocytosis,GO:0016192~vesicle-mediated transport,GO:0072583~clathrin-mediated endocytosis, GO:0005905~clathrin-coated pit,GO:0016020~membrane,GO:0016023~cytoplasmic, membrane-bounded vesicle,GO:0030118~clathrin coat,GO:0030125~clathrin vesicle coat,GO:0030130~clathrin coat of trans-Golgi network vesicle,GO:0030132~clathrin coat of coated pit,GO:0030136~clathrin-coated vesicle,GO:0031410~cytoplasmic vesicle,GO:0043231~intracellular membrane-bounded organelle,GO:0071439~clathrin complex, GO:0005198~structural molecule activity,GO:0032050~clathrin heavy chain binding,GO:0042277~peptide binding, IPR000996:Clathrin light chain, mmu04142:Lysosome,mmu04144:Endocytosis,mmu04721:Synaptic vesicle cycle,mmu04961:Endocrine and other factor-regulated calcium reabsorption,mmu05016:Huntington's disease,mmu05100:Bacterial invasion of epithelial cells, Acetylation,Calcium,Cell cycle,Cell division,Coated pit,Coiled coil,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Cytoskeleton,Membrane,Mitosis,Phosphoprotein,Proteomics identification,Reference proteome, chain:Clathrin light chain A,modified residue,region of interest:Involved in binding clathrin heavy chain, Q5ZJL4 cleavage and polyadenylation factor I subunit 1(CLP1) Gallus gallus GO:0006378~mRNA polyadenylation,GO:0006379~mRNA cleavage,GO:0006388~tRNA splicing, via endonucleolytic cleavage and ligation,GO:0016310~phosphorylation,GO:0021695~cerebellar cortex development,GO:0030423~targeting of mRNA for destruction involved in RNA interference,GO:0035087~siRNA loading onto RISC involved in RNA interference, GO:0000214~tRNA-intron endonuclease complex,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005849~mRNA cleavage factor complex, GO:0005524~ATP binding,GO:0046404~ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity,GO:0051731~polynucleotide 5'-hydroxyl-kinase activity,GO:0051733~polydeoxyribonucleotide kinase activity,GO:0051736~ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity, IPR010655:Pre-mRNA cleavage complex II Clp1,IPR027417:P-loop containing nucleoside triphosphate hydrolase, gga03015:mRNA surveillance pathway, ATP-binding,Complete proteome,Kinase,mRNA processing,Nucleotide-binding,Nucleus,Reference proteome,Transferase,tRNA processing, chain:Polyribonucleotide 5'-hydroxyl-kinase Clp1,nucleotide phosphate-binding region:ATP, Q6DC04 coactivator-associated arginine methyltransferase 1(carm1) Danio rerio GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006479~protein methylation,GO:0016569~covalent chromatin modification,GO:0032259~methylation,GO:0033146~regulation of intracellular estrogen receptor signaling pathway,GO:0034969~histone arginine methylation,GO:0034971~histone H3-R17 methylation,GO:0045600~positive regulation of fat cell differentiation,GO:0048742~regulation of skeletal muscle fiber development, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0003713~transcription coactivator activity,GO:0008168~methyltransferase activity,GO:0008469~histone-arginine N-methyltransferase activity,GO:0008757~S-adenosylmethionine-dependent methyltransferase activity,GO:0016274~protein-arginine N-methyltransferase activity,GO:0016740~transferase activity,GO:0030374~ligand-dependent nuclear receptor transcription coactivator activity,GO:0035242~protein-arginine omega-N asymmetric methyltransferase activity,GO:0035642~histone methyltransferase activity (H3-R17 specific),GO:0042054~histone methyltransferase activity,GO:0044212~transcription regulatory region DNA binding,GO:0070577~lysine-acetylated histone binding, IPR020989:Histone-arginine methyltransferase CARM1, N-terminal,IPR025799:Protein arginine N-methyltransferase, Chromatin regulator,Complete proteome,Cytoplasm,Membrane,Methyltransferase,Nucleus,Proteomics identification,Reference proteome,S-adenosyl-L-methionine,Transcription,Transcription regulation,Transferase,Transmembrane,Transmembrane helix, binding site:S-adenosyl-L-methionine,binding site:S-adenosyl-L-methionine; via carbonyl oxygen,chain:Histone-arginine methyltransferase CARM1,region of interest:Transactivation domain, Q9P1Z9 coiled-coil domain containing 180(CCDC180) Homo sapiens GO:0016021~integral component of membrane,GO:0070062~extracellular exosome, IPR026701:Uncharacterised protein C9orf174, Alternative splicing,Coiled coil,Complete proteome,Membrane,Polymorphism,Reference proteome,Transmembrane,Transmembrane helix, Q0V9R4 coiled-coil domain containing 39(ccdc39) Xenopus tropicalis GO:0003341~cilium movement,GO:0036159~inner dynein arm assembly,GO:0060285~cilium-dependent cell motility,GO:0060287~epithelial cilium movement involved in determination of left/right asymmetry,GO:0070286~axonemal dynein complex assembly, GO:0005737~cytoplasm,GO:0005930~axoneme, IPR023139:Yst0336-like domain, Cell projection,Cilium,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Reference proteome, Q9D8L5 coiled-coil domain containing 91(Ccdc91) Mus musculus GO:0006810~transport,GO:0015031~protein transport, GO:0005654~nucleoplasm,GO:0005794~Golgi apparatus,GO:0016020~membrane, GO:0042802~identical protein binding, Alternative splicing,Coiled coil,Complete proteome,Golgi apparatus,Membrane,Phosphoprotein,Protein transport,Reference proteome,Transport, chain:Coiled-coil domain-containing protein 91,region of interest:GGA1-binding motif,region of interest:Homodimerization,sequence conflict,splice variant, O75534 cold shock domain containing E1(CSDE1) Homo sapiens GO:0006355~regulation of transcription, DNA-templated,GO:0008584~male gonad development,GO:0070966~nuclear-transcribed mRNA catabolic process, no-go decay, GO:0005737~cytoplasm,GO:0005743~mitochondrial inner membrane,GO:0005794~Golgi apparatus,GO:0005886~plasma membrane,GO:0070937~CRD-mediated mRNA stability complex, GO:0003677~DNA binding,GO:0005515~protein binding,GO:0044822~poly(A) RNA binding, IPR002059:Cold-shock protein, DNA-binding,IPR011129:Cold shock protein,IPR012340:Nucleic acid-binding, OB-fold,IPR019844:Cold-shock conserved site,IPR024642:SUZ-C domain, SM00357:CSP, 3D-structure,Acetylation,Alternative splicing,Complete proteome,Cytoplasm,Isopeptide bond,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,RNA-binding,Ubl conjugation, chain:Cold shock domain-containing protein E1,domain:CSD 1,domain:CSD 2; truncated,domain:CSD 3,domain:CSD 4; truncated,domain:CSD 5,domain:CSD 6,domain:CSD 7,domain:CSD 8,domain:CSD 9,helix,modified residue,sequence conflict,splice variant,strand,turn, A2AX52 collagen, type VI, alpha 4(Col6a4) Mus musculus GO:0007155~cell adhesion,GO:0030198~extracellular matrix organization,GO:0070208~protein heterotrimerization, GO:0005576~extracellular region,GO:0005578~proteinaceous extracellular matrix,GO:0005581~collagen trimer,GO:0043234~protein complex, IPR002035:von Willebrand factor, type A,IPR008160:Collagen triple helix repeat, mmu04151:PI3K-Akt signaling pathway,mmu04510:Focal adhesion,mmu04512:ECM-receptor interaction,mmu04974:Protein digestion and absorption, SM00327:VWA, Cell adhesion,Collagen,Complete proteome,Extracellular matrix,Glycoprotein,Hydroxylation,Reference proteome,Repeat,Secreted,Signal, chain:Collagen alpha-4(VI) chain,domain:VWFA 1,domain:VWFA 2,domain:VWFA 3,domain:VWFA 4,domain:VWFA 5,domain:VWFA 6,domain:VWFA 7,domain:VWFA 8,glycosylation site:N-linked (GlcNAc...),region of interest:Nonhelical region,region of interest:Triple-helical region,short sequence motif:Cell attachment site,signal peptide, Q3SXB8 collectin sub-family member 11(Colec11) Mus musculus GO:0007275~multicellular organism development,GO:0032502~developmental process, GO:0005576~extracellular region,GO:0005581~collagen trimer, GO:0005537~mannose binding,GO:0030246~carbohydrate binding, IPR001304:C-type lectin,IPR008160:Collagen triple helix repeat,IPR016186:C-type lectin-like,IPR016187:C-type lectin fold,IPR018378:C-type lectin, conserved site, mmu04145:Phagosome, SM00034:CLECT, Alternative splicing,Calcium,Coiled coil,Collagen,Complete proteome,Developmental protein,Disulfide bond,Lectin,Mannose-binding,Proteomics identification,Reference proteome,Secreted,Signal, chain:Collectin-11,disulfide bond,domain:C-type lectin,domain:Collagen-like,sequence conflict,signal peptide,splice variant, O88992 complement component 1, q subcomponent-like 1(C1ql1) Mus musculus GO:0016322~neuron remodeling,GO:0061743~motor learning,GO:0099558~maintenance of synapse structure, GO:0005576~extracellular region,GO:0005581~collagen trimer,GO:0005737~cytoplasm,GO:0043083~synaptic cleft,GO:0044301~climbing fiber,GO:0098793~presynapse, GO:0005102~receptor binding,GO:0005515~protein binding, IPR001073:Complement C1q protein,IPR008160:Collagen triple helix repeat,IPR008983:Tumour necrosis factor-like domain, SM00110:C1Q, 3D-structure,Collagen,Complete proteome,Reference proteome,Secreted,Signal, chain:C1q-related factor,domain:C1q,domain:Collagen-like,signal peptide, Q5ZJB4 conserved helix-loop-helix ubiquitous kinase(CHUK) Gallus gallus GO:0002224~toll-like receptor signaling pathway,GO:0007252~I-kappaB phosphorylation,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0071356~cellular response to tumor necrosis factor, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane, GO:0005524~ATP binding,GO:0008384~IkappaB kinase activity,GO:0042803~protein homodimerization activity,GO:0046982~protein heterodimerization activity, IPR000719:Protein kinase, catalytic domain,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site,IPR022007:I-kappa-kinase-beta NEMO binding domain, gga04010:MAPK signaling pathway,gga04068:FoxO signaling pathway,gga04210:Apoptosis,gga04620:Toll-like receptor signaling pathway,gga04621:NOD-like receptor signaling pathway,gga04622:RIG-I-like receptor signaling pathway,gga04623:Cytosolic DNA-sensing pathway,gga04920:Adipocytokine signaling pathway,gga05168:Herpes simplex infection, SM00220:S_TKc,SM01239:SM01239, ATP-binding,Complete proteome,Cytoplasm,Kinase,Nucleotide-binding,Nucleus,Phosphoprotein,Reference proteome,Serine/threonine-protein kinase,Transferase, active site:Proton acceptor,binding site:ATP,chain:Inhibitor of nuclear factor kappa-B kinase subunit alpha,domain:Leucine-zipper,domain:Protein kinase,nucleotide phosphate-binding region:ATP,region of interest:NEMO-binding, O75131 copine 3(CPNE3) Homo sapiens GO:0006468~protein phosphorylation,GO:0006629~lipid metabolic process,GO:0016192~vesicle-mediated transport,GO:0030335~positive regulation of cell migration,GO:0038128~ERBB2 signaling pathway,GO:0046474~glycerophospholipid biosynthetic process,GO:0071277~cellular response to calcium ion,GO:0071363~cellular response to growth factor stimulus, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005925~focal adhesion,GO:0030054~cell junction,GO:0070062~extracellular exosome, GO:0004674~protein serine/threonine kinase activity,GO:0005215~transporter activity,GO:0005515~protein binding,GO:0005544~calcium-dependent phospholipid binding,GO:0030971~receptor tyrosine kinase binding,GO:0044822~poly(A) RNA binding,GO:0048306~calcium-dependent protein binding, IPR000008:C2 calcium-dependent membrane targeting,IPR002035:von Willebrand factor, type A,IPR010734:Copine, SM00239:C2,SM00327:VWA, Cell junction,Cell membrane,Complete proteome,Cytoplasm,Direct protein sequencing,Membrane,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat, chain:Copine-3,domain:C2 1,domain:C2 2,domain:VWFA,modified residue,sequence conflict,sequence variant, Q54FY7 copine E(cpnE) Dictyostelium discoideum AX4 GO:0005829~cytosol, GO:0004674~protein serine/threonine kinase activity, IPR000008:C2 calcium-dependent membrane targeting,IPR002035:von Willebrand factor, type A,IPR010734:Copine, SM00239:C2,SM00327:VWA, Complete proteome,Reference proteome,Repeat, Q07DZ5 cortactin binding protein 2(CTTNBP2) Ornithorhynchus anatinus GO:0005938~cell cortex,GO:0016021~integral component of membrane,GO:0043197~dendritic spine, IPR002110:Ankyrin repeat,IPR019131:Cortactin-binding protein-2, N-terminal,IPR020683:Ankyrin repeat-containing domain, SM00248:ANK, ANK repeat,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Membrane,Methylation,Phosphoprotein,Reference proteome,Repeat,Transmembrane,Transmembrane helix, O70244 cubilin(Cubn) Rattus norvegicus GO:0001701~in utero embryonic development,GO:0006766~vitamin metabolic process,GO:0006898~receptor-mediated endocytosis,GO:0007584~response to nutrient,GO:0008203~cholesterol metabolic process,GO:0015031~protein transport,GO:0015889~cobalamin transport,GO:0020028~hemoglobin import,GO:0042953~lipoprotein transport,GO:0070207~protein homotrimerization, GO:0005737~cytoplasm,GO:0005765~lysosomal membrane,GO:0005768~endosome,GO:0005783~endoplasmic reticulum,GO:0005794~Golgi apparatus,GO:0005903~brush border,GO:0005905~clathrin-coated pit,GO:0010008~endosome membrane,GO:0016020~membrane,GO:0016324~apical plasma membrane,GO:0030135~coated vesicle,GO:0030139~endocytic vesicle,GO:0030666~endocytic vesicle membrane,GO:0031526~brush border membrane,GO:0043202~lysosomal lumen,GO:0043234~protein complex,GO:0045177~apical part of cell,GO:0070062~extracellular exosome, GO:0004872~receptor activity,GO:0005509~calcium ion binding,GO:0015235~cobalamin transporter activity,GO:0030492~hemoglobin binding,GO:0031419~cobalamin binding,GO:0042802~identical protein binding,GO:0042803~protein homodimerization activity, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR000859:CUB domain,IPR001881:EGF-like calcium-binding,IPR013032:EGF-like, conserved site,IPR018097:EGF-like calcium-binding, conserved site,IPR024731:EGF domain, merozoite surface protein 1-like, rno04977:Vitamin digestion and absorption, SM00042:CUB,SM00179:EGF_CA,SM00181:EGF, Calcium,Cholesterol metabolism,Cleavage on pair of basic residues,Cobalamin,Cobalt,Coiled coil,Complete proteome,Direct protein sequencing,Disulfide bond,EGF-like domain,Endosome,Glycoprotein,Lipid metabolism,Lysosome,Membrane,Metal-binding,Phosphoprotein,Protein transport,Reference proteome,Repeat,Signal,Steroid metabolism,Sterol metabolism,Transport, chain:Cubilin,disulfide bond,domain:CUB 1,domain:CUB 10,domain:CUB 11,domain:CUB 12,domain:CUB 13,domain:CUB 14,domain:CUB 15,domain:CUB 16,domain:CUB 17,domain:CUB 18,domain:CUB 19,domain:CUB 2,domain:CUB 20,domain:CUB 21,domain:CUB 22,domain:CUB 23,domain:CUB 24,domain:CUB 25,domain:CUB 26,domain:CUB 27,domain:CUB 3,domain:CUB 4,domain:CUB 5,domain:CUB 6,domain:CUB 7,domain:CUB 8,domain:CUB 9,domain:EGF-like 1,domain:EGF-like 2; calcium-binding,domain:EGF-like 3; calcium-binding,domain:EGF-like 4; calcium-binding,domain:EGF-like 5,domain:EGF-like 6,domain:EGF-like 7; calcium-binding,glycosylation site:N-linked (GlcNAc...),propeptide:Removed in mature form,signal peptide,site:Cleavage; by furin, Q6GPF3 cullin 3 S homeolog(cul3.S) Xenopus laevis GO:0006513~protein monoubiquitination,GO:0006888~ER to Golgi vesicle-mediated transport,GO:0007080~mitotic metaphase plate congression,GO:0007229~integrin-mediated signaling pathway,GO:0016477~cell migration,GO:0016567~protein ubiquitination,GO:0017145~stem cell division,GO:0035024~negative regulation of Rho protein signal transduction,GO:0040016~embryonic cleavage,GO:0043149~stress fiber assembly,GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process,GO:0045842~positive regulation of mitotic metaphase/anaphase transition,GO:0048208~COPII vesicle coating, GO:0000139~Golgi membrane,GO:0005634~nucleus,GO:0005827~polar microtubule,GO:0031463~Cul3-RING ubiquitin ligase complex, IPR001373:Cullin, N-terminal,IPR011991:Winged helix-turn-helix DNA-binding domain,IPR016157:Cullin, conserved site,IPR016158:Cullin homology,IPR016159:Cullin repeat-like-containing domain,IPR019559:Cullin protein, neddylation domain, xla04120:Ubiquitin mediated proteolysis, SM00182:CULLIN,SM00884:SM00884, ER-Golgi transport,Isopeptide bond,Nucleus,Transport,Ubl conjugation, chain:Cullin-3-B,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8), Q26619 cyclic AMP-dependent protein kinase type II regulatory subunit(LOC373288) Strongylocentrotus purpuratus GO:0005952~cAMP-dependent protein kinase complex, GO:0008603~cAMP-dependent protein kinase regulator activity,GO:0030552~cAMP binding, IPR000595:Cyclic nucleotide-binding domain,IPR003117:cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta,IPR012198:cAMP-dependent protein kinase regulatory subunit,IPR014710:RmlC-like jelly roll fold,IPR018488:Cyclic nucleotide-binding, conserved site,IPR018490:Cyclic nucleotide-binding-like, PIRSF000548:cAMP-dependent protein kinase, regulatory subunit, SM00100:cNMP,SM00394:RIIa, cAMP,cAMP-binding,Complete proteome,Nucleotide-binding,Phosphoprotein,Reference proteome,Repeat, binding site:cAMP 1,binding site:cAMP 2,chain:cAMP-dependent protein kinase type II regulatory subunit,modified residue,nucleotide phosphate-binding region:cAMP 1,nucleotide phosphate-binding region:cAMP 2,region of interest:Dimerization and phosphorylation, Q14028 cyclic nucleotide gated channel beta 1(CNGB1) Homo sapiens GO:0001895~retina homeostasis,GO:0006810~transport,GO:0006812~cation transport,GO:0007601~visual perception,GO:0007608~sensory perception of smell,GO:0016056~rhodopsin mediated signaling pathway,GO:0022400~regulation of rhodopsin mediated signaling pathway,GO:0033365~protein localization to organelle,GO:0035845~photoreceptor cell outer segment organization,GO:0042391~regulation of membrane potential,GO:0045494~photoreceptor cell maintenance,GO:0050908~detection of light stimulus involved in visual perception,GO:0051290~protein heterotetramerization,GO:0051480~regulation of cytosolic calcium ion concentration,GO:0071805~potassium ion transmembrane transport, GO:0000139~Golgi membrane,GO:0001750~photoreceptor outer segment,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0017071~intracellular cyclic nucleotide activated cation channel complex,GO:0030660~Golgi-associated vesicle membrane,GO:0043195~terminal bouton,GO:0060170~ciliary membrane,GO:1902495~transmembrane transporter complex, GO:0005221~intracellular cyclic nucleotide activated cation channel activity,GO:0005222~intracellular cAMP activated cation channel activity,GO:0005223~intracellular cGMP activated cation channel activity,GO:0005249~voltage-gated potassium channel activity,GO:0005515~protein binding,GO:0015276~ligand-gated ion channel activity,GO:0030552~cAMP binding,GO:0030553~cGMP binding, IPR000595:Cyclic nucleotide-binding domain,IPR014710:RmlC-like jelly roll fold,IPR018488:Cyclic nucleotide-binding, conserved site,IPR018490:Cyclic nucleotide-binding-like, hsa04022:cGMP-PKG signaling pathway,hsa04024:cAMP signaling pathway,hsa04740:Olfactory transduction,hsa04744:Phototransduction, 613767~Retinitis pigmentosa 45, SM00100:cNMP, Alternative splicing,cAMP,cAMP-binding,Complete proteome,Disease mutation,Ion channel,Ion transport,Ligand-gated ion channel,Membrane,Nucleotide-binding,Olfaction,Polymorphism,Proteomics identification,Reference proteome,Retinitis pigmentosa,Sensory transduction,Transmembrane,Transmembrane helix,Transport,Vision, binding site:cAMP,chain:Cyclic nucleotide-gated cation channel beta-1,compositionally biased region:Glu-rich,compositionally biased region:Poly-Glu,compositionally biased region:Pro-rich,mutagenesis site,nucleotide phosphate-binding region:cAMP,sequence conflict,sequence variant,short sequence motif:IQ-like,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q5R754 cyclin dependent kinase like 2(CDKL2) Pongo abelii GO:1903955~positive regulation of protein targeting to mitochondrion, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005813~centrosome, GO:0004672~protein kinase activity,GO:0004693~cyclin-dependent protein serine/threonine kinase activity,GO:0005524~ATP binding, IPR000719:Protein kinase, catalytic domain,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, SM00220:S_TKc, ATP-binding,Complete proteome,Cytoplasm,Kinase,Nucleotide-binding,Nucleus,Reference proteome,Serine/threonine-protein kinase,Transferase, active site:Proton acceptor,binding site:ATP,chain:Cyclin-dependent kinase-like 2,domain:Protein kinase,nucleotide phosphate-binding region:ATP,short sequence motif:[NKR]KIAxRE, O35495 cyclin-dependent kinase 14(Cdk14) Mus musculus GO:0000086~G2/M transition of mitotic cell cycle,GO:0006468~protein phosphorylation,GO:0007049~cell cycle,GO:0016055~Wnt signaling pathway,GO:0016310~phosphorylation,GO:0051301~cell division,GO:0060828~regulation of canonical Wnt signaling pathway, GO:0000308~cytoplasmic cyclin-dependent protein kinase holoenzyme complex,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0016020~membrane, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0004693~cyclin-dependent protein serine/threonine kinase activity,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0016740~transferase activity,GO:0030332~cyclin binding, IPR000719:Protein kinase, catalytic domain,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, mmu05202:Transcriptional misregulation in cancer, SM00220:S_TKc, Alternative splicing,ATP-binding,Cell cycle,Cell division,Cell membrane,Complete proteome,Cytoplasm,Kinase,Membrane,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Serine/threonine-protein kinase,Signal,Transferase,Wnt signaling pathway, active site:Proton acceptor,binding site:ATP,chain:Cell division protein kinase 14,domain:Protein kinase,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict, Q91WT9 cystathionine beta-synthase(Cbs) Mus musculus m_methioninePathway:Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine, GO:0001958~endochondral ossification,GO:0001974~blood vessel remodeling,GO:0006535~cysteine biosynthetic process from serine,GO:0006563~L-serine metabolic process,GO:0006801~superoxide metabolic process,GO:0008652~cellular amino acid biosynthetic process,GO:0019343~cysteine biosynthetic process via cystathionine,GO:0019344~cysteine biosynthetic process,GO:0019346~transsulfuration,GO:0021587~cerebellum morphogenesis,GO:0030823~regulation of cGMP metabolic process,GO:0043066~negative regulation of apoptotic process,GO:0043418~homocysteine catabolic process,GO:0043506~regulation of JUN kinase activity,GO:0050667~homocysteine metabolic process,GO:0050880~regulation of blood vessel size,GO:0051593~response to folic acid,GO:0060135~maternal process involved in female pregnancy,GO:0060351~cartilage development involved in endochondral bone morphogenesis,GO:0070814~hydrogen sulfide biosynthetic process,GO:0071456~cellular response to hypoxia, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0004122~cystathionine beta-synthase activity,GO:0004124~cysteine synthase activity,GO:0016829~lyase activity,GO:0019825~oxygen binding,GO:0019899~enzyme binding,GO:0020037~heme binding,GO:0030170~pyridoxal phosphate binding,GO:0031625~ubiquitin protein ligase binding,GO:0042802~identical protein binding,GO:0042803~protein homodimerization activity,GO:0046872~metal ion binding,GO:0050421~nitrite reductase (NO-forming) activity,GO:0070025~carbon monoxide binding,GO:0070026~nitric oxide binding,GO:0072341~modified amino acid binding,GO:1904047~S-adenosyl-L-methionine binding, IPR000644:Cystathionine beta-synthase, core,IPR001216:Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site,IPR001926:Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily,IPR005857:Cystathionine beta-synthase, mmu00260:Glycine, serine and threonine metabolism,mmu00270:Cysteine and methionine metabolism,mmu01100:Metabolic pathways,mmu01130:Biosynthesis of antibiotics,mmu01230:Biosynthesis of amino acids, SM00116:CBS, Alternative splicing,Amino-acid biosynthesis,CBS domain,Complete proteome,Cysteine biosynthesis,Cytoplasm,Heme,Iron,Isopeptide bond,Lyase,Metal-binding,Nucleus,Phosphoprotein,Proteomics identification,Pyridoxal phosphate,Reference proteome,Ubl conjugation, binding site:Pyridoxal phosphate,chain:Cystathionine beta-synthase,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO),domain:CBS,metal ion-binding site:Iron (heme axial ligand),modified residue,region of interest:Pyridoxal phosphate binding,splice variant, P32929 cystathionine gamma-lyase(CTH) Homo sapiens h_methioninePathway:Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine, GO:0000098~sulfur amino acid catabolic process,GO:0006534~cysteine metabolic process,GO:0018272~protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine,GO:0019343~cysteine biosynthetic process via cystathionine,GO:0019344~cysteine biosynthetic process,GO:0019346~transsulfuration,GO:0030968~endoplasmic reticulum unfolded protein response,GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling,GO:0044524~protein sulfhydration,GO:0051092~positive regulation of NF-kappaB transcription factor activity,GO:0051289~protein homotetramerization,GO:0070814~hydrogen sulfide biosynthetic process,GO:0071266~'de novo' L-methionine biosynthetic process,GO:1904831~positive regulation of aortic smooth muscle cell differentiation,GO:2001234~negative regulation of apoptotic signaling pathway, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0070062~extracellular exosome, GO:0003962~cystathionine gamma-synthase activity,GO:0004123~cystathionine gamma-lyase activity,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0016846~carbon-sulfur lyase activity,GO:0030170~pyridoxal phosphate binding,GO:0042802~identical protein binding,GO:0044540~L-cystine L-cysteine-lyase (deaminating),GO:0047982~homocysteine desulfhydrase activity,GO:0080146~L-cysteine desulfhydrase activity, IPR000277:Cys/Met metabolism, pyridoxal phosphate-dependent enzyme,IPR015421:Pyridoxal phosphate-dependent transferase, major region, subdomain 1,IPR015422:Pyridoxal phosphate-dependent transferase, major region, subdomain 2,IPR015424:Pyridoxal phosphate-dependent transferase, hsa00260:Glycine, serine and threonine metabolism,hsa00270:Cysteine and methionine metabolism,hsa00450:Selenocompound metabolism,hsa01100:Metabolic pathways,hsa01130:Biosynthesis of antibiotics,hsa01230:Biosynthesis of amino acids, 219500~Cystathioninuria,Homocysteine, total plasma, elevated~Homocysteine, total plasma, elevated, PIRSF001434:cystathionine gamma-synthase, 3D-structure,Alternative splicing,Amino-acid biosynthesis,Calmodulin-binding,Complete proteome,Cysteine biosynthesis,Cytoplasm,Disease mutation,Lyase,Polymorphism,Pyridoxal phosphate,Reference proteome, binding site:Substrate,chain:Cystathionine gamma-lyase,helix,modified residue,sequence variant,splice variant,strand,turn, Q29RL2 cysteine and histidine rich domain containing 1(CHORDC1) Bos taurus GO:0010824~regulation of centrosome duplication,GO:0061077~chaperone-mediated protein folding,GO:1900034~regulation of cellular response to heat,GO:2000299~negative regulation of Rho-dependent protein serine/threonine kinase activity, GO:0005524~ATP binding,GO:0008270~zinc ion binding,GO:0043531~ADP binding,GO:0051879~Hsp90 protein binding, IPR007051:Cysteine/histidine-rich domain,IPR007052:CS-like domain,IPR008978:HSP20-like chaperone, Acetylation,Chaperone,Complete proteome,Metal-binding,Phosphoprotein,Reference proteome,Repeat,Stress response,Zinc, chain:Cysteine and histidine-rich domain- containing protein 1,domain:CHORD 1,domain:CHORD 2,domain:CS,metal ion-binding site:Zinc 1,metal ion-binding site:Zinc 2,metal ion-binding site:Zinc 3,metal ion-binding site:Zinc 4,modified residue,region of interest:Interaction with HSP90AA1 and HSP90AB1,region of interest:Interaction with PPP5C, Q7T3Q2 cysteine rich transmembrane BMP regulator 1 (chordin-like)(crim1) Danio rerio GO:0001558~regulation of cell growth,GO:0001568~blood vessel development,GO:0001756~somitogenesis,GO:0048570~notochord morphogenesis, GO:0005576~extracellular region,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0004857~enzyme inhibitor activity,GO:0004867~serine-type endopeptidase inhibitor activity,GO:0005520~insulin-like growth factor binding, IPR000867:Insulin-like growth factor-binding protein, IGFBP,IPR001007:von Willebrand factor, type C,IPR004094:Proteinase inhibitor I15, antistasin-like,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR011061:Proteinase inhibitor I14/I15, hirudin/antistatin, SM00121:IB,SM00214:VWC,SM00215:VWC_out, Complete proteome,Glycoprotein,Membrane,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Cysteine-rich motor neuron 1 protein,domain:Antistasin-like 1,domain:Antistasin-like 2,domain:Antistasin-like 3,domain:Antistasin-like 4,domain:IGFBP N-terminal,domain:VWFC 1,domain:VWFC 2,domain:VWFC 3,domain:VWFC 4,domain:VWFC 5,domain:VWFC 6,glycosylation site:N-linked (GlcNAc...),short sequence motif:Cell attachment site,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q4R550 cysteinyl-tRNA synthetase(CARS) Macaca fascicularis GO:0006423~cysteinyl-tRNA aminoacylation, GO:0005737~cytoplasm, GO:0000049~tRNA binding,GO:0004817~cysteine-tRNA ligase activity,GO:0005524~ATP binding,GO:0046872~metal ion binding, IPR009080:Aminoacyl-tRNA synthetase, class 1a, anticodon-binding,IPR014729:Rossmann-like alpha/beta/alpha sandwich fold,IPR015803:Cysteine-tRNA ligase,IPR024909:Cysteinyl-tRNA synthetase/mycothiol ligase, mcf00970:Aminoacyl-tRNA biosynthesis, Acetylation,Aminoacyl-tRNA synthetase,ATP-binding,Cytoplasm,Ligase,Metal-binding,Nucleotide-binding,Phosphoprotein,Protein biosynthesis,Zinc, Q5F408 cysteinyl-tRNA synthetase(CARS) Gallus gallus Translation, ribosomal structure and biogenesis, GO:0006423~cysteinyl-tRNA aminoacylation, GO:0005737~cytoplasm, GO:0000049~tRNA binding,GO:0004817~cysteine-tRNA ligase activity,GO:0005524~ATP binding,GO:0042803~protein homodimerization activity,GO:0046872~metal ion binding, IPR009080:Aminoacyl-tRNA synthetase, class 1a, anticodon-binding,IPR010987:Glutathione S-transferase, C-terminal-like,IPR014729:Rossmann-like alpha/beta/alpha sandwich fold,IPR015803:Cysteine-tRNA ligase,IPR024909:Cysteinyl-tRNA synthetase/mycothiol ligase, gga00970:Aminoacyl-tRNA biosynthesis, Aminoacyl-tRNA synthetase,ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Ligase,Metal-binding,Nucleotide-binding,Protein biosynthesis,Reference proteome,Zinc, binding site:ATP,chain:Cysteinyl-tRNA synthetase, cytoplasmic,metal ion-binding site:Zinc,short sequence motif:"HIGH" region,short sequence motif:"KMSKS" region, A1A5G0 cytoplasmic linker associated protein 1(clasp1) Xenopus tropicalis GO:0007020~microtubule nucleation,GO:0007067~mitotic nuclear division,GO:0031023~microtubule organizing center organization,GO:0034453~microtubule anchoring,GO:0051301~cell division, GO:0000777~condensed chromosome kinetochore,GO:0005794~Golgi apparatus,GO:0005815~microtubule organizing center,GO:0005828~kinetochore microtubule,GO:0005881~cytoplasmic microtubule, IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold,IPR021133:HEAT, type 2,IPR024395:CLASP N-terminal domain, Cell cycle,Cell division,Centromere,Chromosome,Complete proteome,Cytoplasm,Cytoskeleton,Golgi apparatus,Kinetochore,Microtubule,Mitosis,Reference proteome,Repeat, Q5RC69 dCMP deaminase(DCTD) Pongo abelii GO:0006220~pyrimidine nucleotide metabolic process,GO:0009165~nucleotide biosynthetic process, GO:0070062~extracellular exosome, GO:0004132~dCMP deaminase activity,GO:0008270~zinc ion binding, IPR002125:CMP/dCMP deaminase, zinc-binding,IPR015517:Cytidine deaminase,IPR016192:APOBEC/CMP deaminase, zinc-binding,IPR016193:Cytidine deaminase-like,IPR016473:dCMP deaminase, pon00240:Pyrimidine metabolism,pon01100:Metabolic pathways, PIRSF006019:dCMP deaminase, Allosteric enzyme,Complete proteome,Hydrolase,Metal-binding,Nucleotide biosynthesis,Phosphoprotein,Reference proteome,Zinc, Q805F9 damage-specific DNA binding protein 1, 127kDa(DDB1) Gallus gallus RNA processing and modification, GO:0006281~DNA repair,GO:0006289~nucleotide-excision repair,GO:0016055~Wnt signaling pathway,GO:0016567~protein ubiquitination,GO:0035518~histone H2A monoubiquitination,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process,GO:0043066~negative regulation of apoptotic process,GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process,GO:0045070~positive regulation of viral genome replication,GO:0046726~positive regulation by virus of viral protein levels in host cell,GO:0051702~interaction with symbiont,GO:0070914~UV-damage excision repair,GO:1901990~regulation of mitotic cell cycle phase transition,GO:1902188~positive regulation of viral release from host cell, GO:0000784~nuclear chromosome, telomeric region,GO:0005615~extracellular space,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0031461~cullin-RING ubiquitin ligase complex,GO:0031464~Cul4A-RING E3 ubiquitin ligase complex,GO:0031465~Cul4B-RING E3 ubiquitin ligase complex,GO:0070062~extracellular exosome,GO:0080008~Cul4-RING E3 ubiquitin ligase complex, GO:0003684~damaged DNA binding, IPR004871:Cleavage/polyadenylation specificity factor, A subunit, C-terminal,IPR011047:Quinonprotein alcohol dehydrogenase-like superfamily,IPR015943:WD40/YVTN repeat-like-containing domain, gga03420:Nucleotide excision repair,gga04120:Ubiquitin mediated proteolysis, Complete proteome,Cytoplasm,DNA damage,DNA repair,DNA-binding,Nucleus,Reference proteome,Repeat,Ubl conjugation pathway, chain:DNA damage-binding protein 1, Q9GKX2 dehydrogenase/reductase (SDR family) member 4(DHRS4) Oryctolagus cuniculus GO:0042574~retinal metabolic process, GO:0005739~mitochondrion,GO:0005777~peroxisome, GO:0001758~retinal dehydrogenase activity,GO:0004090~carbonyl reductase (NADPH) activity,GO:0016491~oxidoreductase activity, IPR002347:Glucose/ribitol dehydrogenase,IPR016040:NAD(P)-binding domain,IPR020904:Short-chain dehydrogenase/reductase, conserved site, ocu00830:Retinol metabolism,ocu01100:Metabolic pathways,ocu04146:Peroxisome, Acetylation,Complete proteome,Direct protein sequencing,NADP,Oxidoreductase,Peroxisome,Phosphoprotein,Reference proteome, active site:Proton acceptor,binding site:Substrate,chain:Dehydrogenase/reductase SDR family member 4,nucleotide phosphate-binding region:NADP,short sequence motif:Microbody targeting signal, Q9Y238 deleted in lung and esophageal cancer 1(DLEC1) Homo sapiens GO:0008285~negative regulation of cell proliferation, GO:0005737~cytoplasm, 133239~Esophageal cancer,211980~Lung cancer, Alternative splicing,Complete proteome,Cytoplasm,Polymorphism,Reference proteome,Tumor suppressor, chain:Deleted in lung and esophageal cancer protein 1,sequence conflict,sequence variant,splice variant, Q9UGM3 deleted in malignant brain tumors 1(DMBT1) Homo sapiens GO:0002221~pattern recognition receptor signaling pathway,GO:0006898~receptor-mediated endocytosis,GO:0007275~multicellular organism development,GO:0015031~protein transport,GO:0030855~epithelial cell differentiation,GO:0043152~induction of bacterial agglutination,GO:0044267~cellular protein metabolic process,GO:0045087~innate immune response,GO:0051607~defense response to virus, GO:0005576~extracellular region,GO:0005615~extracellular space,GO:0005737~cytoplasm,GO:0016020~membrane,GO:0019898~extrinsic component of membrane,GO:0030670~phagocytic vesicle membrane,GO:0042589~zymogen granule membrane,GO:0070062~extracellular exosome, GO:0005044~scavenger receptor activity,GO:0005515~protein binding,GO:0008329~signaling pattern recognition receptor activity,GO:0035375~zymogen binding,GO:0048306~calcium-dependent protein binding, IPR000859:CUB domain,IPR001190:Speract/scavenger receptor,IPR001507:Zona pellucida domain,IPR017448:Speract/scavenger receptor-related,IPR017977:Zona pellucida domain, conserved site, hsa04970:Salivary secretion, SM00042:CUB,SM00202:SR,SM00241:ZP, Alternative splicing,Antiviral defense,Complete proteome,Developmental protein,Differentiation,Direct protein sequencing,Disulfide bond,Glycoprotein,Host-virus interaction,Polymorphism,Protein transport,Reference proteome,Repeat,Secreted,Signal,Transport,Tumor suppressor, chain:Deleted in malignant brain tumors 1 protein,compositionally biased region:Poly-Thr,disulfide bond,domain:CUB 1,domain:CUB 2,domain:SRCR 1,domain:SRCR 10,domain:SRCR 11,domain:SRCR 12,domain:SRCR 13,domain:SRCR 14,domain:SRCR 2,domain:SRCR 3,domain:SRCR 4,domain:SRCR 5,domain:SRCR 6,domain:SRCR 7,domain:SRCR 8,domain:SRCR 9,domain:ZP,glycosylation site:N-linked (GlcNAc...),sequence conflict,sequence variant,signal peptide,splice variant, P49366 deoxyhypusine synthase(DHPS) Homo sapiens GO:0006412~translation,GO:0008284~positive regulation of cell proliferation,GO:0008612~peptidyl-lysine modification to peptidyl-hypusine,GO:0042102~positive regulation of T cell proliferation,GO:0042593~glucose homeostasis,GO:0050983~deoxyhypusine biosynthetic process from spermidine,GO:0051289~protein homotetramerization, GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0005515~protein binding,GO:0034038~deoxyhypusine synthase activity,GO:0042802~identical protein binding, IPR002773:Deoxyhypusine synthase, 3D-structure,Alternative splicing,Complete proteome,Direct protein sequencing,Hypusine biosynthesis,NAD,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transferase, active site:Nucleophile,binding site:NAD,binding site:NAD; via amide nitrogen,binding site:Spermidine,chain:Deoxyhypusine synthase,helix,modified residue,mutagenesis site,nucleotide phosphate-binding region:NAD,region of interest:Spermidine binding,sequence conflict,sequence variant,splice variant,strand,turn, P23919 deoxythymidylate kinase(DTYMK) Homo sapiens GO:0006227~dUDP biosynthetic process,GO:0006233~dTDP biosynthetic process,GO:0006235~dTTP biosynthetic process,GO:0007049~cell cycle,GO:0008283~cell proliferation,GO:0015949~nucleobase-containing small molecule interconversion,GO:0043627~response to estrogen,GO:0045445~myoblast differentiation,GO:0046686~response to cadmium ion,GO:0046939~nucleotide phosphorylation,GO:0046940~nucleoside monophosphate phosphorylation,GO:0071363~cellular response to growth factor stimulus, GO:0005634~nucleus,GO:0005739~mitochondrion,GO:0005758~mitochondrial intermembrane space,GO:0005759~mitochondrial matrix,GO:0005829~cytosol, GO:0004798~thymidylate kinase activity,GO:0005524~ATP binding,GO:0009041~uridylate kinase activity,GO:0016301~kinase activity,GO:0050145~nucleoside phosphate kinase activity, IPR018094:Thymidylate kinase,IPR018095:Thymidylate kinase, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa00240:Pyrimidine metabolism,hsa01100:Metabolic pathways, 3D-structure,Acetylation,Alternative splicing,ATP-binding,Complete proteome,Kinase,Nucleotide biosynthesis,Nucleotide-binding,Proteomics identification,Reference proteome,Transferase, chain:Thymidylate kinase,helix,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,strand, O60879 diaphanous related formin 2(DIAPH2) Homo sapiens GO:0000910~cytokinesis,GO:0007015~actin filament organization,GO:0007275~multicellular organism development,GO:0007292~female gamete generation,GO:0048477~oogenesis, GO:0005730~nucleolus,GO:0005739~mitochondrion,GO:0005769~early endosome,GO:0005794~Golgi apparatus,GO:0005829~cytosol,GO:0043231~intracellular membrane-bounded organelle, GO:0003779~actin binding,GO:0005102~receptor binding,GO:0017048~Rho GTPase binding, IPR010465:DRF autoregulatory,IPR010472:Diaphanous FH3,IPR010473:Diaphanous GTPase-binding,IPR014767:Diaphanous autoregulatory,IPR014768:GTPase-binding/formin homology 3,IPR015425:Actin-binding FH2,IPR016024:Armadillo-type fold, hsa04810:Regulation of actin cytoskeleton, 300511~Premature ovarian failure, SM00498:FH2,SM01139:SM01139,SM01140:SM01140, Acetylation,Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Developmental protein,Differentiation,Endosome,Oogenesis,Polymorphism,Premature ovarian failure,Proteomics identification,Reference proteome,Repeat, chain:Protein diaphanous homolog 2,compositionally biased region:Arg/Lys-rich (basic),compositionally biased region:Poly-Leu,compositionally biased region:Poly-Lys,compositionally biased region:Poly-Pro,compositionally biased region:Poly-Ser,domain:DAD,domain:FH1,domain:FH2,domain:GBD/FH3,modified residue,sequence variant,splice variant, P09623 dihydrolipoamide dehydrogenase(DLD) Sus scrofa GO:0006120~mitochondrial electron transport, NADH to ubiquinone,GO:0006508~proteolysis,GO:0007369~gastrulation,GO:0042391~regulation of membrane potential,GO:0045454~cell redox homeostasis,GO:0048240~sperm capacitation,GO:0055114~oxidation-reduction process, GO:0005654~nucleoplasm,GO:0005739~mitochondrion,GO:0005759~mitochondrial matrix,GO:0005929~cilium,GO:0043159~acrosomal matrix,GO:0043209~myelin sheath,GO:0045254~pyruvate dehydrogenase complex, GO:0004148~dihydrolipoyl dehydrogenase activity,GO:0016668~oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor,GO:0034604~pyruvate dehydrogenase (NAD+) activity,GO:0050660~flavin adenine dinucleotide binding, IPR004099:Pyridine nucleotide-disulphide oxidoreductase, dimerisation,IPR006258:Dihydrolipoamide dehydrogenase,IPR012999:Pyridine nucleotide-disulphide oxidoreductase, class I, active site,IPR016156:FAD/NAD-linked reductase, dimerisation,IPR023753:Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain, ssc00010:Glycolysis / Gluconeogenesis,ssc00020:Citrate cycle (TCA cycle),ssc00260:Glycine, serine and threonine metabolism,ssc00280:Valine, leucine and isoleucine degradation,ssc00620:Pyruvate metabolism,ssc00630:Glyoxylate and dicarboxylate metabolism,ssc01100:Metabolic pathways,ssc01130:Biosynthesis of antibiotics,ssc01200:Carbon metabolism, Acetylation,Complete proteome,Direct protein sequencing,Disulfide bond,FAD,Flavoprotein,Mitochondrion,NAD,Oxidoreductase,Phosphoprotein,Proteomics identification,Redox-active center,Reference proteome,Transit peptide, active site:Proton acceptor,binding site:FAD,binding site:FAD; via amide nitrogen and carbonyl oxygen,binding site:NAD,binding site:NAD; via amide nitrogen,binding site:NAD; via amide nitrogen and carbonyl oxygen,chain:Dihydrolipoyl dehydrogenase, mitochondrial,disulfide bond,modified residue,nucleotide phosphate-binding region:FAD,nucleotide phosphate-binding region:NAD,sequence conflict,transit peptide:Mitochondrion, Q8C2P3 dihydrouridine synthase 1-like (S. cerevisiae)(Dus1l) Mus musculus Translation, ribosomal structure and biogenesis, GO:0008033~tRNA processing,GO:0055114~oxidation-reduction process, GO:0005829~cytosol, GO:0003824~catalytic activity,GO:0016491~oxidoreductase activity,GO:0017150~tRNA dihydrouridine synthase activity,GO:0050660~flavin adenine dinucleotide binding, IPR001269:tRNA-dihydrouridine synthase,IPR013785:Aldolase-type TIM barrel,IPR018517:tRNA-dihydrouridine synthase, conserved site, Complete proteome,Flavoprotein,FMN,Oxidoreductase,Proteomics identification,Reference proteome,tRNA processing, chain:tRNA-dihydrouridine synthase 1-like,modified residue,sequence conflict, Q7ZWS1 dihydrouridine synthase 3-like L homeolog(dus3l.L) Xenopus laevis GO:0017150~tRNA dihydrouridine synthase activity,GO:0046872~metal ion binding,GO:0050660~flavin adenine dinucleotide binding, IPR000571:Zinc finger, CCCH-type,IPR001269:tRNA-dihydrouridine synthase,IPR013785:Aldolase-type TIM barrel,IPR018517:tRNA-dihydrouridine synthase, conserved site, Flavoprotein,FMN,Metal-binding,Oxidoreductase,Repeat,tRNA processing,Zinc,Zinc-finger, chain:tRNA-dihydrouridine synthase 3-like,zinc finger region:C3H1-type 1,zinc finger region:C3H1-type 2, Q3UHC7 disabled 2 interacting protein(Dab2ip) Mus musculus Cell division and chromosome partitioning, GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0000185~activation of MAPKKK activity,GO:0001525~angiogenesis,GO:0001933~negative regulation of protein phosphorylation,GO:0002376~immune system process,GO:0006915~apoptotic process,GO:0006954~inflammatory response,GO:0006986~response to unfolded protein,GO:0007049~cell cycle,GO:0007165~signal transduction,GO:0007252~I-kappaB phosphorylation,GO:0007257~activation of JUN kinase activity,GO:0007275~multicellular organism development,GO:0008285~negative regulation of cell proliferation,GO:0008625~extrinsic apoptotic signaling pathway via death domain receptors,GO:0010596~negative regulation of endothelial cell migration,GO:0010633~negative regulation of epithelial cell migration,GO:0010719~negative regulation of epithelial to mesenchymal transition,GO:0010976~positive regulation of neuron projection development,GO:0014067~negative regulation of phosphatidylinositol 3-kinase signaling,GO:0016525~negative regulation of angiogenesis,GO:0021814~cell motility involved in cerebral cortex radial glia guided migration,GO:0021819~layer formation in cerebral cortex,GO:0030308~negative regulation of cell growth,GO:0030948~negative regulation of vascular endothelial growth factor receptor signaling pathway,GO:0032088~negative regulation of NF-kappaB transcription factor activity,GO:0034144~negative regulation of toll-like receptor 4 signaling pathway,GO:0034260~negative regulation of GTPase activity,GO:0035148~tube formation,GO:0035414~negative regulation of catenin import into nucleus,GO:0035924~cellular response to vascular endothelial growth factor stimulus,GO:0036324~vascular endothelial growth factor receptor-2 signaling pathway,GO:0038026~reelin-mediated signaling pathway,GO:0040008~regulation of growth,GO:0042059~negative regulation of epidermal growth factor receptor signaling pathway,GO:0043065~positive regulation of apoptotic process,GO:0043087~regulation of GTPase activity,GO:0043122~regulation of I-kappaB kinase/NF-kappaB signaling,GO:0043124~negative regulation of I-kappaB kinase/NF-kappaB signaling,GO:0043254~regulation of protein complex assembly,GO:0043407~negative regulation of MAP kinase activity,GO:0043410~positive regulation of MAPK cascade,GO:0043497~regulation of protein heterodimerization activity,GO:0043507~positive regulation of JUN kinase activity,GO:0043553~negative regulation of phosphatidylinositol 3-kinase activity,GO:0044257~cellular protein catabolic process,GO:0045087~innate immune response,GO:0045732~positive regulation of protein catabolic process,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0046330~positive regulation of JNK cascade,GO:0046580~negative regulation of Ras protein signal transduction,GO:0048147~negative regulation of fibroblast proliferation,GO:0048812~neuron projection morphogenesis,GO:0050679~positive regulation of epithelial cell proliferation,GO:0050680~negative regulation of epithelial cell proliferation,GO:0070059~intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress,GO:0070317~negative regulation of G0 to G1 transition,GO:0070373~negative regulation of ERK1 and ERK2 cascade,GO:0071158~positive regulation of cell cycle arrest,GO:0071222~cellular response to lipopolysaccharide,GO:0071347~cellular response to interleukin-1,GO:0071356~cellular response to tumor necrosis factor,GO:0071364~cellular response to epidermal growth factor stimulus,GO:0071901~negative regulation of protein serine/threonine kinase activity,GO:0071902~positive regulation of protein serine/threonine kinase activity,GO:0090090~negative regulation of canonical Wnt signaling pathway,GO:0090129~positive regulation of synapse maturation,GO:1900006~positive regulation of dendrite development,GO:1900744~regulation of p38MAPK cascade,GO:1900747~negative regulation of vascular endothelial growth factor signaling pathway,GO:1901800~positive regulation of proteasomal protein catabolic process,GO:1903363~negative regulation of cellular protein catabolic process,GO:2000599~negative regulation of cyclin catabolic process,GO:2001224~positive regulation of neuron migration,GO:2001235~positive regulation of apoptotic signaling pathway, GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0005913~cell-cell adherens junction,GO:0016020~membrane,GO:0030139~endocytic vesicle,GO:0030424~axon,GO:0030425~dendrite,GO:0031235~intrinsic component of the cytoplasmic side of the plasma membrane,GO:0032809~neuronal cell body membrane,GO:0042995~cell projection,GO:0043025~neuronal cell body,GO:0044300~cerebellar mossy fiber,GO:0044301~climbing fiber,GO:0070062~extracellular exosome,GO:1990032~parallel fiber,GO:1990597~AIP1-IRE1 complex, GO:0005096~GTPase activator activity,GO:0005123~death receptor binding,GO:0005515~protein binding,GO:0017124~SH3 domain binding,GO:0019900~kinase binding,GO:0019901~protein kinase binding,GO:0031434~mitogen-activated protein kinase kinase binding,GO:0031435~mitogen-activated protein kinase kinase kinase binding,GO:0032266~phosphatidylinositol-3-phosphate binding,GO:0032403~protein complex binding,GO:0035591~signaling adaptor activity,GO:0035662~Toll-like receptor 4 binding,GO:0036312~phosphatidylinositol 3-kinase regulatory subunit binding,GO:0042802~identical protein binding,GO:0042803~protein homodimerization activity,GO:0043184~vascular endothelial growth factor receptor 2 binding,GO:0043548~phosphatidylinositol 3-kinase binding,GO:0047485~protein N-terminus binding,GO:0051721~protein phosphatase 2A binding,GO:0070273~phosphatidylinositol-4-phosphate binding,GO:0071889~14-3-3 protein binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000008:C2 calcium-dependent membrane targeting,IPR001849:Pleckstrin homology domain,IPR001936:Ras GTPase-activating protein,IPR008936:Rho GTPase activation protein,IPR011993:Pleckstrin homology-like domain,IPR021887:Protein of unknown function DUF3498,IPR023152:Ras GTPase-activating protein, conserved site, SM00233:PH,SM00239:C2,SM00323:RasGAP, Alternative splicing,Angiogenesis,Apoptosis,Cell cycle,Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Developmental protein,Growth regulation,GTPase activation,Immunity,Inflammatory response,Innate immunity,Membrane,Phosphoprotein,Proteomics identification,Reference proteome,Stress response,Tumor suppressor,Unfolded protein response, chain:Disabled homolog 2-interacting protein,compositionally biased region:Arg-rich,compositionally biased region:Poly-Ala,compositionally biased region:Pro-rich,domain:C2,domain:PH,domain:Ras-GAP,modified residue,splice variant, Q8TDM6 discs large MAGUK scaffold protein 5(DLG5) Homo sapiens DNA replication, recombination, and repair, GO:0006461~protein complex assembly,GO:0007165~signal transduction,GO:0008285~negative regulation of cell proliferation,GO:0016337~single organismal cell-cell adhesion,GO:0030859~polarized epithelial cell differentiation,GO:0030901~midbrain development,GO:0035556~intracellular signal transduction,GO:0042981~regulation of apoptotic process,GO:0045176~apical protein localization,GO:0045186~zonula adherens assembly,GO:0045197~establishment or maintenance of epithelial cell apical/basal polarity,GO:0060441~epithelial tube branching involved in lung morphogenesis,GO:0071896~protein localization to adherens junction,GO:0072205~metanephric collecting duct development, GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0005913~cell-cell adherens junction, GO:0005515~protein binding,GO:0008013~beta-catenin binding,GO:0008092~cytoskeletal protein binding,GO:0030159~receptor signaling complex scaffold activity, IPR001315:Caspase Recruitment,IPR001452:Src homology-3 domain,IPR001478:PDZ domain,IPR006907:Domain of unknown function DUF622,IPR008144:Guanylate kinase,IPR008145:Guanylate kinase/L-type calcium channel,IPR011029:Death-like domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00072:GuKc,SM00228:PDZ,SM00326:SH3, 3D-structure,Alternative splicing,Cell junction,Cell membrane,Coiled coil,Complete proteome,Membrane,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,SH3 domain, chain:Disks large homolog 5,compositionally biased region:Poly-Ser,compositionally biased region:Pro-rich,domain:Guanylate kinase-like,domain:PDZ 1,domain:PDZ 2,domain:PDZ 3,domain:PDZ 4,domain:SH3,helix,modified residue,sequence variant,splice variant,strand,turn, Q5PYH5 discs, large (Drosophila) homolog 1, like(dlg1l) Danio rerio GO:0001935~endothelial cell proliferation,GO:0007015~actin filament organization,GO:0007268~chemical synaptic transmission,GO:0007399~nervous system development,GO:0016337~single organismal cell-cell adhesion,GO:0030866~cortical actin cytoskeleton organization,GO:0043113~receptor clustering,GO:0045197~establishment or maintenance of epithelial cell apical/basal polarity,GO:0045930~negative regulation of mitotic cell cycle,GO:0050808~synapse organization,GO:0097120~receptor localization to synapse, GO:0008328~ionotropic glutamate receptor complex,GO:0014069~postsynaptic density,GO:0016020~membrane,GO:0016323~basolateral plasma membrane,GO:0045211~postsynaptic membrane, GO:0004385~guanylate kinase activity,GO:0019901~protein kinase binding,GO:0019902~phosphatase binding,GO:0035255~ionotropic glutamate receptor binding, IPR001452:Src homology-3 domain,IPR001478:PDZ domain,IPR004172:L27,IPR008144:Guanylate kinase,IPR008145:Guanylate kinase/L-type calcium channel,IPR011511:Variant SH3,IPR015143:L27-1,IPR016313:Membrane-associated guanylate kinase (MAGUK) scaffold protein,IPR019583:PDZ-associated domain of NMDA receptors,IPR019590:Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal,IPR020590:Guanylate kinase, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, PIRSF001741:membrane-associated guanylate kinase (MAGUK) scaffold protein, SM00072:GuKc,SM00228:PDZ,SM00326:SH3,SM00569:L27,SM01277:SM01277, Complete proteome,Membrane,Reference proteome,Repeat,SH3 domain, chain:Discs large homolog 1-like protein,domain:Guanylate kinase-like,domain:PDZ 1,domain:PDZ 2,domain:PDZ 3,domain:SH3, Q28C55 discs, large homolog 1(dlg1) Xenopus tropicalis GO:0007268~chemical synaptic transmission,GO:0007399~nervous system development,GO:0043113~receptor clustering,GO:0045197~establishment or maintenance of epithelial cell apical/basal polarity,GO:0097120~receptor localization to synapse, GO:0005789~endoplasmic reticulum membrane,GO:0014069~postsynaptic density,GO:0016323~basolateral plasma membrane,GO:0030054~cell junction,GO:0045211~postsynaptic membrane, GO:0004385~guanylate kinase activity,GO:0035255~ionotropic glutamate receptor binding, IPR001452:Src homology-3 domain,IPR001478:PDZ domain,IPR004172:L27,IPR008144:Guanylate kinase,IPR008145:Guanylate kinase/L-type calcium channel,IPR015143:L27-1,IPR016313:Membrane-associated guanylate kinase (MAGUK) scaffold protein,IPR019583:PDZ-associated domain of NMDA receptors,IPR019590:Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal,IPR020590:Guanylate kinase, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, PIRSF001741:membrane-associated guanylate kinase (MAGUK) scaffold protein, SM00072:GuKc,SM00228:PDZ,SM00326:SH3,SM00569:L27,SM01277:SM01277, Alternative splicing,Cell junction,Complete proteome,Endoplasmic reticulum,Membrane,Reference proteome,Repeat,SH3 domain, chain:Disks large homolog 1,domain:Guanylate kinase-like,domain:L27,domain:PDZ 1,domain:PDZ 2,domain:PDZ 3,domain:SH3,splice variant, B1WAP7 dishevelled segment polarity protein 3(dvl3) Xenopus tropicalis GO:0016055~Wnt signaling pathway,GO:0032053~ciliary basal body organization,GO:0035556~intracellular signal transduction,GO:0042384~cilium assembly,GO:0060070~canonical Wnt signaling pathway,GO:0090179~planar cell polarity pathway involved in neural tube closure, GO:0005622~intracellular,GO:0005829~cytosol, GO:0005109~frizzled binding,GO:0008013~beta-catenin binding, IPR000591:DEP domain,IPR001158:DIX domain,IPR001478:PDZ domain,IPR003351:Dishevelled protein domain,IPR008339:Dishevelled family,IPR008342:Dishevelled-3,IPR011991:Winged helix-turn-helix DNA-binding domain,IPR015506:Dishevelled-related protein,IPR024580:Dishevelled C-terminal, xtr04310:Wnt signaling pathway,xtr04330:Notch signaling pathway,xtr04916:Melanogenesis, SM00021:DAX,SM00049:DEP,SM00228:PDZ, Cilium biogenesis/degradation,Complete proteome,Cytoplasm,Developmental protein,Reference proteome,Wnt signaling pathway, chain:Segment polarity protein dishevelled homolog DVL-3,compositionally biased region:His-rich,domain:DEP,domain:DIX,domain:PDZ, P15330 dorsal(dl) Drosophila melanogaster GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0000381~regulation of alternative mRNA splicing, via spliceosome,GO:0001715~ectodermal cell fate specification,GO:0006355~regulation of transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0006952~defense response,GO:0006955~immune response,GO:0006964~positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria,GO:0007249~I-kappaB kinase/NF-kappaB signaling,GO:0007369~gastrulation,GO:0007398~ectoderm development,GO:0007419~ventral cord development,GO:0007498~mesoderm development,GO:0007501~mesodermal cell fate specification,GO:0007507~heart development,GO:0008063~Toll signaling pathway,GO:0008354~germ cell migration,GO:0009950~dorsal/ventral axis specification,GO:0009952~anterior/posterior pattern specification,GO:0009953~dorsal/ventral pattern formation,GO:0010004~gastrulation involving germ band extension,GO:0010629~negative regulation of gene expression,GO:0010906~regulation of glucose metabolic process,GO:0034097~response to cytokine,GO:0035006~melanization defense response,GO:0035206~regulation of hemocyte proliferation,GO:0038061~NIK/NF-kappaB signaling,GO:0042387~plasmatocyte differentiation,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0048935~peripheral nervous system neuron development, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0031594~neuromuscular junction,GO:0033256~I-kappaB/NF-kappaB complex,GO:0071212~subsynaptic reticulum, GO:0000977~RNA polymerase II regulatory region sequence-specific DNA binding,GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding,GO:0003677~DNA binding,GO:0003682~chromatin binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0003705~transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding,GO:0005515~protein binding,GO:0043565~sequence-specific DNA binding,GO:0070379~high mobility group box 1 binding,GO:0070491~repressing transcription factor binding, IPR000451:NF-kappa-B/Rel/Dorsal,IPR002909:Cell surface receptor IPT/TIG,IPR008967:p53-like transcription factor, DNA-binding,IPR011363:Dorsal protein,IPR011539:Rel homology domain,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set, PIRSF001716:dorsal protein, SM00429:IPT, Activator,Alternative splicing,Complete proteome,Cytoplasm,Developmental protein,DNA-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Transcription,Transcription regulation, chain:Embryonic polarity protein dorsal,compositionally biased region:Gln-rich,compositionally biased region:Pro-rich,domain:RHD,modified residue,sequence conflict,short sequence motif:Nuclear localization signal,splice variant, Q71B07 dpy-19-like 3 (C. elegans)(Dpy19l3) Mus musculus GO:0018406~protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan, GO:0005637~nuclear inner membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0000030~mannosyltransferase activity,GO:0016740~transferase activity,GO:0016757~transferase activity, transferring glycosyl groups, IPR018732:Dpy-19, Complete proteome,Glycosyltransferase,Membrane,Proteomics identification,Reference proteome,Transferase,Transmembrane,Transmembrane helix, chain:Protein dpy-19 homolog 3,compositionally biased region:Leu-rich,sequence conflict,transmembrane region, A6H7G2 drebrin like(DBNL) Bos taurus GO:0002250~adaptive immune response,GO:0006898~receptor-mediated endocytosis,GO:0007416~synapse assembly,GO:0016601~Rac protein signal transduction,GO:0048812~neuron projection morphogenesis,GO:0071800~podosome assembly,GO:0097178~ruffle assembly,GO:0098609~cell-cell adhesion, GO:0000139~Golgi membrane,GO:0001726~ruffle,GO:0002102~podosome,GO:0005769~early endosome,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005913~cell-cell adherens junction,GO:0005938~cell cortex,GO:0030027~lamellipodium,GO:0030054~cell junction,GO:0030665~clathrin-coated vesicle membrane,GO:0045202~synapse,GO:0070062~extracellular exosome, GO:0019904~protein domain specific binding,GO:0051015~actin filament binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR001452:Src homology-3 domain,IPR002108:Actin-binding, cofilin/tropomyosin type, SM00102:ADF,SM00326:SH3, Acetylation,Actin-binding,Adaptive immunity,Cell junction,Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Cytoskeleton,Endocytosis,Endosome,Golgi apparatus,Immunity,Membrane,Phosphoprotein,Reference proteome,SH3 domain,Synapse,Transport, chain:Drebrin-like protein,domain:ADF-H,domain:SH3,modified residue,site:Cleavage; by caspase-3, Q9NRR4 drosha ribonuclease III(DROSHA) Homo sapiens GO:0010586~miRNA metabolic process,GO:0010628~positive regulation of gene expression,GO:0016075~rRNA catabolic process,GO:0030422~production of siRNA involved in RNA interference,GO:0031047~gene silencing by RNA,GO:0031053~primary miRNA processing,GO:0031054~pre-miRNA processing,GO:0042254~ribosome biogenesis,GO:0045589~regulation of regulatory T cell differentiation,GO:0050727~regulation of inflammatory response,GO:0050829~defense response to Gram-negative bacterium,GO:0050830~defense response to Gram-positive bacterium,GO:0090502~RNA phosphodiester bond hydrolysis, endonucleolytic,GO:2000628~regulation of miRNA metabolic process, GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0070877~microprocessor complex, GO:0001530~lipopolysaccharide binding,GO:0003725~double-stranded RNA binding,GO:0004525~ribonuclease III activity,GO:0005515~protein binding,GO:0042803~protein homodimerization activity,GO:0044822~poly(A) RNA binding,GO:0046872~metal ion binding,GO:0070878~primary miRNA binding, IPR000999:Ribonuclease III domain,IPR011907:Ribonuclease III,IPR014720:Double-stranded RNA-binding-like domain, hsa03008:Ribosome biogenesis in eukaryotes,hsa05205:Proteoglycans in cancer, SM00358:DSRM,SM00535:RIBOc, 3D-structure,Alternative splicing,Complete proteome,Endonuclease,Hydrolase,Magnesium,Manganese,Metal-binding,Nuclease,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Ribosome biogenesis,RNA-binding,RNA-mediated gene silencing, chain:Ribonuclease 3,compositionally biased region:Arg-rich,compositionally biased region:Pro-rich,domain:DRBM,domain:RNase III 1,domain:RNase III 2,metal ion-binding site:Magnesium or manganese,modified residue,mutagenesis site,region of interest:Necessary for interaction with DGCR8 and pri-miRNA processing activity,sequence conflict,sequence variant,site:Important for activity,splice variant, Q9BY84 dual specificity phosphatase 16(DUSP16) Homo sapiens GO:0000188~inactivation of MAPK activity,GO:0016311~dephosphorylation,GO:0035335~peptidyl-tyrosine dephosphorylation,GO:0045204~MAPK export from nucleus,GO:0045209~MAPK phosphatase export from nucleus, leptomycin B sensitive, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0016023~cytoplasmic, membrane-bounded vesicle,GO:0031410~cytoplasmic vesicle, GO:0004721~phosphoprotein phosphatase activity,GO:0004725~protein tyrosine phosphatase activity,GO:0016791~phosphatase activity,GO:0017017~MAP kinase tyrosine/serine/threonine phosphatase activity, IPR000340:Dual specificity phosphatase, catalytic domain,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR001763:Rhodanese-like domain,IPR008343:Mitogen-activated protein (MAP) kinase phosphatase,IPR016130:Protein-tyrosine phosphatase, active site,IPR020422:Dual specificity phosphatase, subgroup, catalytic domain,IPR024950:Dual specificity phosphatase, hsa04010:MAPK signaling pathway, SM00195:DSPc,SM00450:RHOD, 3D-structure,Alternative splicing,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Hydrolase,Nucleus,Phosphoprotein,Polymorphism,Protein phosphatase,Proteomics identification,Reference proteome, active site:Phosphocysteine intermediate,chain:Dual specificity protein phosphatase 16,domain:Rhodanese,domain:Tyrosine-protein phosphatase,helix,modified residue,sequence variant,strand, O09112 dual specificity phosphatase 8(Dusp8) Mus musculus m_dspPathway:Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases, GO:0000188~inactivation of MAPK activity,GO:0006470~protein dephosphorylation,GO:0016311~dephosphorylation, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0016021~integral component of membrane, GO:0004721~phosphoprotein phosphatase activity,GO:0004725~protein tyrosine phosphatase activity,GO:0008138~protein tyrosine/serine/threonine phosphatase activity,GO:0016787~hydrolase activity,GO:0016791~phosphatase activity,GO:0017017~MAP kinase tyrosine/serine/threonine phosphatase activity, IPR000340:Dual specificity phosphatase, catalytic domain,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR001763:Rhodanese-like domain,IPR008343:Mitogen-activated protein (MAP) kinase phosphatase,IPR016130:Protein-tyrosine phosphatase, active site,IPR020422:Dual specificity phosphatase, subgroup, catalytic domain,IPR024950:Dual specificity phosphatase, mmu04010:MAPK signaling pathway, SM00195:DSPc,SM00450:RHOD, Complete proteome,Cytoplasm,Hydrolase,Membrane,Nucleus,Protein phosphatase,Reference proteome,Transmembrane,Transmembrane helix, active site:Phosphocysteine intermediate,chain:Dual specificity protein phosphatase 8,compositionally biased region:Poly-Arg,compositionally biased region:Poly-Gly,compositionally biased region:Poly-Ser,compositionally biased region:Pro-rich,domain:Rhodanese,domain:Tyrosine-protein phosphatase, Q14203 dynactin subunit 1(DCTN1) Homo sapiens h_Lis1Pathway:Lissencephaly gene (LIS1) in neuronal migration and development, GO:0000086~G2/M transition of mitotic cell cycle,GO:0006888~ER to Golgi vesicle-mediated transport,GO:0007067~mitotic nuclear division,GO:0007399~nervous system development,GO:0010457~centriole-centriole cohesion,GO:0010970~establishment of localization by movement along microtubule,GO:0019886~antigen processing and presentation of exogenous peptide antigen via MHC class II,GO:0031116~positive regulation of microtubule polymerization,GO:0032402~melanosome transport,GO:0034454~microtubule anchoring at centrosome,GO:0036498~IRE1-mediated unfolded protein response,GO:0042147~retrograde transport, endosome to Golgi,GO:0051081~nuclear envelope disassembly,GO:0090063~positive regulation of microtubule nucleation, GO:0000776~kinetochore,GO:0000922~spindle pole,GO:0005635~nuclear envelope,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005814~centriole,GO:0005819~spindle,GO:0005829~cytosol,GO:0005869~dynactin complex,GO:0005874~microtubule,GO:0016020~membrane,GO:0030286~dynein complex,GO:0030904~retromer complex,GO:0031252~cell leading edge,GO:0035371~microtubule plus-end, GO:0003774~motor activity,GO:0005515~protein binding,GO:0008017~microtubule binding,GO:0015631~tubulin binding,GO:0045502~dynein binding, IPR000938:CAP Gly-rich domain,IPR022157:Dynein associated protein, hsa04962:Vasopressin-regulated water reabsorption,hsa05016:Huntington's disease, 105400~Amyotrophic lateral sclerosis, susceptibility to,168605~Perry syndrome,607641~Neuropathy, distal hereditary motor, type VIIB, SM01052:SM01052, 3D-structure,Alternative splicing,Amyotrophic lateral sclerosis,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Dynein,Microtubule,Neurodegeneration,Parkinsonism,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transport,Ubl conjugation, chain:Dynactin subunit 1,compositionally biased region:Ser-rich,domain:CAP-Gly,helix,modified residue,sequence conflict,sequence variant,splice variant,strand,turn, Q6P2Y2 dynein assembly factor with WDR repeat domains 1(daw1) Xenopus tropicalis GO:0005929~cilium, IPR001680:WD40 repeat,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site,IPR020472:G-protein beta WD-40 repeat, SM00320:WD40, Cell projection,Cilium,Complete proteome,Reference proteome,Repeat,WD repeat, chain:WD repeat-containing protein 69,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,repeat:WD 8, Q8TE73 dynein axonemal heavy chain 5(DNAH5) Homo sapiens Cytoskeleton, GO:0003341~cilium movement,GO:0007018~microtubule-based movement,GO:0007368~determination of left/right symmetry,GO:0007507~heart development,GO:0021670~lateral ventricle development,GO:0030317~sperm motility,GO:0036158~outer dynein arm assembly,GO:0042384~cilium assembly,GO:0060271~cilium morphogenesis, GO:0005737~cytoplasm,GO:0005874~microtubule,GO:0005930~axoneme,GO:0036157~outer dynein arm, GO:0003777~microtubule motor activity,GO:0005524~ATP binding,GO:0016887~ATPase activity, IPR003593:AAA+ ATPase domain,IPR004273:Dynein heavy chain domain,IPR011704:ATPase, dynein-related, AAA domain,IPR013594:Dynein heavy chain, domain-1,IPR013602:Dynein heavy chain, domain-2,IPR024317:Dynein heavy chain, P-loop containing D4 domain,IPR024743:Dynein heavy chain, coiled coil stalk,IPR026983:Dynein heavy chain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa05016:Huntington's disease, 608644~Ciliary dyskinesia, primary, 3, with or without situs inversus, SM00382:AAA, ATP-binding,Cell projection,Ciliopathy,Cilium,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Disease mutation,Dynein,Kartagener syndrome,Microtubule,Motor protein,Nucleotide-binding,Polymorphism,Primary ciliary dyskinesia,Reference proteome,Repeat, chain:Dynein heavy chain 5, axonemal,modified residue,nucleotide phosphate-binding region:ATP,region of interest:AAA 1,region of interest:AAA 2,region of interest:AAA 3,region of interest:AAA 4,region of interest:AAA 5,region of interest:AAA 6,region of interest:Stalk,region of interest:Stem,sequence conflict,sequence variant, Q9C0G6 dynein axonemal heavy chain 6(DNAH6) Homo sapiens h_Lis1Pathway:Lissencephaly gene (LIS1) in neuronal migration and development, Cytoskeleton, GO:0001539~cilium or flagellum-dependent cell motility,GO:0007018~microtubule-based movement, GO:0005737~cytoplasm,GO:0005858~axonemal dynein complex,GO:0005874~microtubule, GO:0003777~microtubule motor activity,GO:0005524~ATP binding,GO:0016887~ATPase activity, IPR003593:AAA+ ATPase domain,IPR004273:Dynein heavy chain domain,IPR011704:ATPase, dynein-related, AAA domain,IPR013602:Dynein heavy chain, domain-2,IPR024317:Dynein heavy chain, P-loop containing D4 domain,IPR024743:Dynein heavy chain, coiled coil stalk,IPR026980:Dynein heavy chain 6, axonemal,IPR026983:Dynein heavy chain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa05016:Huntington's disease, SM00382:AAA, Alternative splicing,ATP-binding,Cell projection,Cilium,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Dynein,Microtubule,Motor protein,Nucleotide-binding,Proteomics identification,Reference proteome,Repeat, chain:Dynein heavy chain 6, axonemal,nucleotide phosphate-binding region:ATP,region of interest:AAA 1,region of interest:AAA 2,region of interest:AAA 3,region of interest:AAA 4,region of interest:AAA 5,region of interest:AAA 6,region of interest:Stalk,region of interest:Stem,sequence conflict,splice variant, Q8WXX0 dynein axonemal heavy chain 7(DNAH7) Homo sapiens Cytoskeleton, GO:0003341~cilium movement,GO:0036159~inner dynein arm assembly,GO:0060285~cilium-dependent cell motility, GO:0005737~cytoplasm,GO:0005858~axonemal dynein complex,GO:0005874~microtubule,GO:0005929~cilium,GO:0036156~inner dynein arm, GO:0003777~microtubule motor activity,GO:0005509~calcium ion binding,GO:0005524~ATP binding,GO:0016887~ATPase activity, IPR002048:EF-hand domain,IPR003593:AAA+ ATPase domain,IPR004273:Dynein heavy chain domain,IPR013602:Dynein heavy chain, domain-2,IPR018247:EF-Hand 1, calcium-binding site,IPR024317:Dynein heavy chain, P-loop containing D4 domain,IPR024743:Dynein heavy chain, coiled coil stalk,IPR026979:Dynein heavy chain 7, axonemal,IPR026983:Dynein heavy chain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa05016:Huntington's disease, SM00382:AAA, Alternative splicing,ATP-binding,Cell projection,Cilium,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Dynein,Microtubule,Motor protein,Nucleotide-binding,Polymorphism,Reference proteome,Repeat, chain:Dynein heavy chain 7, axonemal,nucleotide phosphate-binding region:ATP,region of interest:AAA 1,region of interest:AAA 2,region of interest:AAA 3,region of interest:AAA 4,region of interest:AAA 5,region of interest:AAA 6,region of interest:Stalk,region of interest:Stem,sequence conflict,sequence variant,splice variant, Q14204 dynein cytoplasmic 1 heavy chain 1(DYNC1H1) Homo sapiens Cytoskeleton, GO:0000086~G2/M transition of mitotic cell cycle,GO:0006888~ER to Golgi vesicle-mediated transport,GO:0007018~microtubule-based movement,GO:0007052~mitotic spindle organization,GO:0019886~antigen processing and presentation of exogenous peptide antigen via MHC class II,GO:0033962~cytoplasmic mRNA processing body assembly,GO:0034063~stress granule assembly,GO:0051293~establishment of spindle localization, GO:0005813~centrosome,GO:0005829~cytosol,GO:0005868~cytoplasmic dynein complex,GO:0005874~microtubule,GO:0016020~membrane,GO:0030175~filopodium,GO:0030286~dynein complex,GO:0031012~extracellular matrix,GO:0070062~extracellular exosome, GO:0003777~microtubule motor activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016887~ATPase activity,GO:0044822~poly(A) RNA binding,GO:0051959~dynein light intermediate chain binding, IPR003593:AAA+ ATPase domain,IPR004273:Dynein heavy chain domain,IPR011704:ATPase, dynein-related, AAA domain,IPR013594:Dynein heavy chain, domain-1,IPR013602:Dynein heavy chain, domain-2,IPR024317:Dynein heavy chain, P-loop containing D4 domain,IPR024743:Dynein heavy chain, coiled coil stalk,IPR026983:Dynein heavy chain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa04145:Phagosome,hsa04962:Vasopressin-regulated water reabsorption,hsa05132:Salmonella infection, 158600~Spinal muscular atrophy, lower extremity-predominant 1, AD,614228~Charcot-Marie-Tooth disease, axonal, type 20,614563~Mental retardation, autosomal dominant 13, SM00382:AAA, 3D-structure,Acetylation,ATP-binding,Charcot-Marie-Tooth disease,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Disease mutation,Dynein,Mental retardation,Microtubule,Motor protein,Neurodegeneration,Neuropathy,Nucleotide-binding,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Transport, chain:Cytoplasmic dynein 1 heavy chain 1,modified residue,nucleotide phosphate-binding region:ATP,region of interest:AAA 1,region of interest:AAA 2,region of interest:AAA 3,region of interest:AAA 4,region of interest:AAA 5,region of interest:AAA 6,region of interest:Stalk,region of interest:Stem,sequence conflict,sequence variant, Q9JHU4 dynein cytoplasmic 1 heavy chain 1(Dync1h1) Mus musculus Cytoskeleton, GO:0003341~cilium movement,GO:0006810~transport,GO:0007018~microtubule-based movement,GO:0033962~cytoplasmic mRNA processing body assembly,GO:0034063~stress granule assembly,GO:0051293~establishment of spindle localization, GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005856~cytoskeleton,GO:0005868~cytoplasmic dynein complex,GO:0005874~microtubule,GO:0016020~membrane,GO:0030175~filopodium,GO:0030286~dynein complex,GO:0031012~extracellular matrix,GO:0070062~extracellular exosome, GO:0000166~nucleotide binding,GO:0003774~motor activity,GO:0003777~microtubule motor activity,GO:0005524~ATP binding,GO:0016887~ATPase activity,GO:0044822~poly(A) RNA binding,GO:0051959~dynein light intermediate chain binding, IPR003593:AAA+ ATPase domain,IPR004273:Dynein heavy chain domain,IPR011704:ATPase, dynein-related, AAA domain,IPR013594:Dynein heavy chain, domain-1,IPR013602:Dynein heavy chain, domain-2,IPR024317:Dynein heavy chain, P-loop containing D4 domain,IPR024743:Dynein heavy chain, coiled coil stalk,IPR026983:Dynein heavy chain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, mmu04145:Phagosome,mmu04962:Vasopressin-regulated water reabsorption,mmu05132:Salmonella infection, SM00382:AAA, 3D-structure,Acetylation,ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Disease mutation,Dynein,Microtubule,Motor protein,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Transport, chain:Cytoplasmic dynein 1 heavy chain 1,helix,modified residue,nucleotide phosphate-binding region:ATP,region of interest:AAA 1,region of interest:AAA 2,region of interest:AAA 3,region of interest:AAA 4,region of interest:AAA 5,region of interest:AAA 6,region of interest:Stalk,region of interest:Stem,sequence variant,turn, B9EJR8 dynein, axonemal assembly factor 5(Dnaaf5) Mus musculus GO:0003341~cilium movement,GO:0030030~cell projection organization,GO:0036158~outer dynein arm assembly,GO:0036159~inner dynein arm assembly, GO:0005737~cytoplasm,GO:0031514~motile cilium, GO:0045505~dynein intermediate chain binding, IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold, Acetylation,Cilium biogenesis/degradation,Complete proteome,Cytoplasm,Proteomics identification,Reference proteome,Repeat, E9Q8T7 dynein, axonemal, heavy chain 1(Dnah1) Mus musculus Cytoskeleton, GO:0003351~epithelial cilium movement,GO:0030317~sperm motility,GO:0036159~inner dynein arm assembly,GO:0060294~cilium movement involved in cell motility, GO:0036126~sperm flagellum,GO:0036156~inner dynein arm, GO:0003777~microtubule motor activity,GO:0005524~ATP binding,GO:0016887~ATPase activity, IPR004273:Dynein heavy chain domain,IPR011704:ATPase, dynein-related, AAA domain,IPR013602:Dynein heavy chain, domain-2,IPR024317:Dynein heavy chain, P-loop containing D4 domain,IPR024743:Dynein heavy chain, coiled coil stalk,IPR026975:Dynein heavy chain 1, axonemal,IPR026983:Dynein heavy chain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, mmu05016:Huntington's disease, Coiled coil,Complete proteome,Proteomics identification,Reference proteome, Q8BW94 dynein, axonemal, heavy chain 3(Dnah3) Mus musculus Cytoskeleton, GO:0007018~microtubule-based movement, GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005874~microtubule,GO:0005929~cilium,GO:0030286~dynein complex,GO:0036156~inner dynein arm,GO:0042995~cell projection, GO:0000166~nucleotide binding,GO:0003774~motor activity,GO:0003777~microtubule motor activity,GO:0005524~ATP binding, IPR003593:AAA+ ATPase domain,IPR004273:Dynein heavy chain domain,IPR013602:Dynein heavy chain, domain-2,IPR024317:Dynein heavy chain, P-loop containing D4 domain,IPR024743:Dynein heavy chain, coiled coil stalk,IPR026983:Dynein heavy chain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, mmu05016:Huntington's disease, SM00382:AAA, Alternative splicing,ATP-binding,Cell projection,Cilium,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Dynein,Microtubule,Motor protein,Nucleotide-binding,Reference proteome, chain:Dynein heavy chain 3, axonemal,modified residue,nucleotide phosphate-binding region:ATP,region of interest:AAA 1,region of interest:AAA 2,region of interest:AAA 3,region of interest:AAA 4,region of interest:AAA 5,region of interest:AAA 6,region of interest:Stalk,region of interest:Stem,repeat:LRR 1,repeat:LRR 10,repeat:LRR 11,repeat:LRR 12,repeat:LRR 13,repeat:LRR 14,repeat:LRR 15,repeat:LRR 16,repeat:LRR 17,repeat:LRR 18,repeat:LRR 19,repeat:LRR 2,repeat:LRR 20,repeat:LRR 3,repeat:LRR 4,repeat:LRR 5,repeat:LRR 6,repeat:LRR 7,repeat:LRR 8,repeat:LRR 9,sequence conflict,splice variant, Q91XQ0 dynein, axonemal, heavy chain 8(Dnah8) Mus musculus Cytoskeleton, GO:0007018~microtubule-based movement, GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005874~microtubule,GO:0005929~cilium,GO:0030286~dynein complex,GO:0031514~motile cilium,GO:0036157~outer dynein arm,GO:0042995~cell projection,GO:0097228~sperm principal piece, GO:0000166~nucleotide binding,GO:0003774~motor activity,GO:0003777~microtubule motor activity,GO:0005524~ATP binding,GO:0016887~ATPase activity, IPR003593:AAA+ ATPase domain,IPR004273:Dynein heavy chain domain,IPR011704:ATPase, dynein-related, AAA domain,IPR013594:Dynein heavy chain, domain-1,IPR013602:Dynein heavy chain, domain-2,IPR024317:Dynein heavy chain, P-loop containing D4 domain,IPR024743:Dynein heavy chain, coiled coil stalk,IPR026983:Dynein heavy chain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, mmu05016:Huntington's disease, SM00382:AAA, Alternative splicing,ATP-binding,Cell projection,Cilium,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Dynein,Flagellum,Microtubule,Motor protein,Nucleotide-binding,Phosphoprotein,Reference proteome,Repeat, chain:Dynein heavy chain 8, axonemal,compositionally biased region:Pro-rich,modified residue,nucleotide phosphate-binding region:ATP,region of interest:AAA 1,region of interest:AAA 2,region of interest:AAA 3,region of interest:AAA 4,region of interest:AAA 5,region of interest:AAA 6,region of interest:Stalk,sequence conflict,splice variant, P84060 dystrobrevin, beta(Dtnb) Rattus norvegicus GO:0005737~cytoplasm,GO:0045202~synapse, GO:0008270~zinc ion binding, IPR000433:Zinc finger, ZZ-type,IPR011992:EF-hand-like domain,IPR015153:EF-hand domain, type 1,IPR015154:EF-hand domain, type 2,IPR017432:Distrobrevin, PIRSF038204:distrobrevin, SM00291:ZnF_ZZ, Coiled coil,Complete proteome,Cytoplasm,Metal-binding,Phosphoprotein,Proteomics identification,Reference proteome,Zinc,Zinc-finger, chain:Dystrobrevin beta,region of interest:Syntrophin-binding region,zinc finger region:ZZ-type, P11532 dystrophin(DMD) Homo sapiens 10.Dysdap, h_agrPathway:Agrin in Postsynaptic Differentiation, GO:0001954~positive regulation of cell-matrix adhesion,GO:0002027~regulation of heart rate,GO:0006355~regulation of transcription, DNA-templated,GO:0007010~cytoskeleton organization,GO:0007517~muscle organ development,GO:0007519~skeletal muscle tissue development,GO:0007568~aging,GO:0008065~establishment of blood-nerve barrier,GO:0010880~regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum,GO:0010881~regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion,GO:0010976~positive regulation of neuron projection development,GO:0014809~regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion,GO:0014819~regulation of skeletal muscle contraction,GO:0014904~myotube cell development,GO:0016203~muscle attachment,GO:0021629~olfactory nerve structural organization,GO:0030049~muscle filament sliding,GO:0033137~negative regulation of peptidyl-serine phosphorylation,GO:0034613~cellular protein localization,GO:0035994~response to muscle stretch,GO:0043043~peptide biosynthetic process,GO:0043623~cellular protein complex assembly,GO:0044458~motile cilium assembly,GO:0045213~neurotransmitter receptor metabolic process,GO:0045666~positive regulation of neuron differentiation,GO:0046716~muscle cell cellular homeostasis,GO:0048747~muscle fiber development,GO:0048812~neuron projection morphogenesis,GO:0051647~nucleus localization,GO:0060048~cardiac muscle contraction,GO:0060314~regulation of ryanodine-sensitive calcium-release channel activity,GO:0060857~establishment of glial blood-brain barrier,GO:0070373~negative regulation of ERK1 and ERK2 cascade,GO:0086001~cardiac muscle cell action potential,GO:0090287~regulation of cellular response to growth factor stimulus,GO:1901385~regulation of voltage-gated calcium channel activity,GO:1902083~negative regulation of peptidyl-cysteine S-nitrosylation,GO:2000651~positive regulation of sodium ion transmembrane transporter activity, GO:0005634~nucleus,GO:0005829~cytosol,GO:0005856~cytoskeleton,GO:0005886~plasma membrane,GO:0009986~cell surface,GO:0016010~dystrophin-associated glycoprotein complex,GO:0016013~syntrophin complex,GO:0016328~lateral plasma membrane,GO:0030018~Z disc,GO:0030055~cell-substrate junction,GO:0030175~filopodium,GO:0031527~filopodium membrane,GO:0042383~sarcolemma,GO:0043034~costamere,GO:0043234~protein complex,GO:0044306~neuron projection terminus,GO:0045121~membrane raft,GO:0045202~synapse,GO:0045211~postsynaptic membrane, GO:0002162~dystroglycan binding,GO:0003779~actin binding,GO:0005200~structural constituent of cytoskeleton,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0008307~structural constituent of muscle,GO:0017022~myosin binding,GO:0017166~vinculin binding,GO:0050998~nitric-oxide synthase binding, IPR000433:Zinc finger, ZZ-type,IPR001202:WW domain,IPR001589:Actinin-type, actin-binding, conserved site,IPR001715:Calponin homology domain,IPR002017:Spectrin repeat,IPR008518:FATE/Miff/Tango-11,IPR011992:EF-hand-like domain,IPR015153:EF-hand domain, type 1,IPR015154:EF-hand domain, type 2,IPR016344:Dystrophin/utrophin,IPR018159:Spectrin/alpha-actinin, hsa05410:Hypertrophic cardiomyopathy (HCM),hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC),hsa05414:Dilated cardiomyopathy,hsa05416:Viral myocarditis, 300376~Becker muscular dystrophy,302045~Cardiomyopathy, dilated, 3B,310200~Duchenne muscular dystrophy, PIRSF002341:dystrophin/utrophin, SM00033:CH,SM00150:SPEC,SM00291:ZnF_ZZ,SM00456:WW, 3D-structure,Actin-binding,Alternative splicing,Calcium,Cardiomyopathy,Cell junction,Cell membrane,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Disease mutation,Membrane,Metal-binding,Phosphoprotein,Polymorphism,Postsynaptic cell membrane,Proteomics identification,Reference proteome,Repeat,Synapse,Zinc,Zinc-finger, chain:Dystrophin,domain:Actin-binding,domain:CH 1,domain:CH 2,domain:WW,helix,modified residue,region of interest:Binds to SNTB1,region of interest:Interaction with SYNM,repeat:Spectrin 1,repeat:Spectrin 10,repeat:Spectrin 11,repeat:Spectrin 12,repeat:Spectrin 13,repeat:Spectrin 14,repeat:Spectrin 15,repeat:Spectrin 16,repeat:Spectrin 17,repeat:Spectrin 18,repeat:Spectrin 19,repeat:Spectrin 2,repeat:Spectrin 20,repeat:Spectrin 21,repeat:Spectrin 22,repeat:Spectrin 3,repeat:Spectrin 4,repeat:Spectrin 5,repeat:Spectrin 6,repeat:Spectrin 7,repeat:Spectrin 8,repeat:Spectrin 9,sequence conflict,sequence variant,splice variant,strand,turn,zinc finger region:ZZ-type, Q8BL66 early endosome antigen 1(Eea1) Mus musculus GO:0006897~endocytosis,GO:0006906~vesicle fusion,GO:0039694~viral RNA genome replication, GO:0005737~cytoplasm,GO:0005768~endosome,GO:0005769~early endosome,GO:0005829~cytosol,GO:0005969~serine-pyruvate aminotransferase complex,GO:0016020~membrane,GO:0019897~extrinsic component of plasma membrane,GO:0031410~cytoplasmic vesicle,GO:0031901~early endosome membrane,GO:0044308~axonal spine,GO:0055037~recycling endosome,GO:0070062~extracellular exosome, GO:0005515~protein binding,GO:0005545~1-phosphatidylinositol binding,GO:0030742~GTP-dependent protein binding,GO:0042803~protein homodimerization activity,GO:0046872~metal ion binding, IPR000306:Zinc finger, FYVE-type,IPR007087:Zinc finger, C2H2,IPR011011:Zinc finger, FYVE/PHD-type,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR015880:Zinc finger, C2H2-like,IPR017455:Zinc finger, FYVE-related, mmu04144:Endocytosis,mmu04145:Phagosome,mmu05152:Tuberculosis, SM00064:FYVE,SM00355:ZnF_C2H2, Coiled coil,Complete proteome,Cytoplasm,Endosome,Membrane,Metal-binding,Phosphoprotein,Reference proteome,Zinc,Zinc-finger, chain:Early endosome antigen 1,compositionally biased region:Gln/Glu/Lys-rich,sequence conflict,zinc finger region:C2H2-type,zinc finger region:FYVE-type, Q16206 ecto-NOX disulfide-thiol exchanger 2(ENOX2) Homo sapiens GO:0007624~ultradian rhythm,GO:0016049~cell growth,GO:0040008~regulation of growth,GO:0055114~oxidation-reduction process, GO:0005615~extracellular space,GO:0005829~cytosol,GO:0009897~external side of plasma membrane, GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0015035~protein disulfide oxidoreductase activity, IPR000504:RNA recognition motif domain,IPR012677:Nucleotide-binding, alpha-beta plait, SM00360:RRM, Alternative splicing,Biological rhythms,Cell membrane,Coiled coil,Complete proteome,Copper,Direct protein sequencing,Electron transport,Glycoprotein,Growth regulation,Membrane,NAD,Oxidoreductase,Polymorphism,Proteomics identification,Reference proteome,Secreted,Transport, chain:Ecto-NOX disulfide-thiol exchanger 2,compositionally biased region:Pro-rich,domain:RRM,mutagenesis site,sequence conflict,splice variant, Q9Y227 ectonucleoside triphosphate diphosphohydrolase 4(ENTPD4) Homo sapiens GO:0006256~UDP catabolic process, GO:0016021~integral component of membrane,GO:0030173~integral component of Golgi membrane,GO:0031410~cytoplasmic vesicle,GO:0043231~intracellular membrane-bounded organelle,GO:0097637~integral component of autophagosome membrane, GO:0016787~hydrolase activity,GO:0045134~uridine-diphosphatase activity, IPR000407:Nucleoside phosphatase GDA1/CD39, hsa00230:Purine metabolism,hsa00240:Pyrimidine metabolism,hsa04142:Lysosome, Alternative splicing,Calcium,Complete proteome,Cytoplasmic vesicle,Disulfide bond,Glycoprotein,Golgi apparatus,Hydrolase,Magnesium,Membrane,Polymorphism,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix, chain:Ectonucleoside triphosphate diphosphohydrolase 4,glycosylation site:N-linked (GlcNAc...),modified residue,sequence conflict,sequence variant,splice variant,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, Q5ZKH3 embryonic ectoderm development(EED) Gallus gallus GO:0006349~regulation of gene expression by genetic imprinting,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0016569~covalent chromatin modification,GO:0061087~positive regulation of histone H3-K27 methylation, GO:0001739~sex chromatin,GO:0005730~nucleolus,GO:0035098~ESC/E(Z) complex,GO:0045120~pronucleus, GO:0003682~chromatin binding,GO:0042054~histone methyltransferase activity, IPR001680:WD40 repeat,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site, SM00320:WD40, Chromatin regulator,Complete proteome,Nucleus,Reference proteome,Repeat,Repressor,Transcription,Transcription regulation,WD repeat, chain:Polycomb protein eed,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7, Q4PZA2 endothelin converting enzyme 1(Ece1) Mus musculus Posttranslational modification, protein turnover, chaperones, GO:0001666~response to hypoxia,GO:0001921~positive regulation of receptor recycling,GO:0006508~proteolysis,GO:0006915~apoptotic process,GO:0007507~heart development,GO:0008217~regulation of blood pressure,GO:0010613~positive regulation of cardiac muscle hypertrophy,GO:0010814~substance P catabolic process,GO:0010815~bradykinin catabolic process,GO:0010816~calcitonin catabolic process,GO:0016485~protein processing,GO:0016486~peptide hormone processing,GO:0030819~positive regulation of cAMP biosynthetic process,GO:0034959~endothelin maturation,GO:0042312~regulation of vasodilation,GO:0042447~hormone catabolic process,GO:0042733~embryonic digit morphogenesis,GO:0043583~ear development,GO:0045745~positive regulation of G-protein coupled receptor protein signaling pathway,GO:0060037~pharyngeal system development,GO:0070372~regulation of ERK1 and ERK2 cascade, GO:0005765~lysosomal membrane,GO:0005768~endosome,GO:0005769~early endosome,GO:0005794~Golgi apparatus,GO:0005886~plasma membrane,GO:0009897~external side of plasma membrane,GO:0009986~cell surface,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030141~secretory granule,GO:0031410~cytoplasmic vesicle,GO:0031982~vesicle,GO:0033093~Weibel-Palade body,GO:0048471~perinuclear region of cytoplasm,GO:0070062~extracellular exosome, GO:0004175~endopeptidase activity,GO:0004222~metalloendopeptidase activity,GO:0008233~peptidase activity,GO:0008237~metallopeptidase activity,GO:0016787~hydrolase activity,GO:0042803~protein homodimerization activity,GO:0046872~metal ion binding, IPR000718:Peptidase M13,IPR008753:Peptidase M13, N-terminal domain,IPR018497:Peptidase M13, C-terminal domain,IPR024079:Metallopeptidase, catalytic domain, Alternative splicing,Cell membrane,Complete proteome,Disulfide bond,Glycoprotein,Hydrolase,Membrane,Metal-binding,Metalloprotease,Phosphoprotein,Protease,Proteomics identification,Reference proteome,Signal,Signal-anchor,Transmembrane,Transmembrane helix,Zinc, active site:Proton donor,chain:Endothelin-converting enzyme 1,disulfide bond,glycosylation site:N-linked (GlcNAc...),metal ion-binding site:Zinc; catalytic,modified residue,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q9H9B1 euchromatic histone lysine methyltransferase 1(EHMT1) Homo sapiens GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0006306~DNA methylation,GO:0006325~chromatin organization,GO:0009790~embryo development,GO:0016571~histone methylation,GO:0018026~peptidyl-lysine monomethylation,GO:0018027~peptidyl-lysine dimethylation,GO:0045892~negative regulation of transcription, DNA-templated,GO:0051567~histone H3-K9 methylation,GO:0060992~response to fungicide,GO:0070734~histone H3-K27 methylation,GO:1901796~regulation of signal transduction by p53 class mediator, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005694~chromosome, GO:0002039~p53 binding,GO:0005515~protein binding,GO:0008168~methyltransferase activity,GO:0008270~zinc ion binding,GO:0016279~protein-lysine N-methyltransferase activity,GO:0018024~histone-lysine N-methyltransferase activity,GO:0046974~histone methyltransferase activity (H3-K9 specific),GO:0046976~histone methyltransferase activity (H3-K27 specific),GO:0070742~C2H2 zinc finger domain binding, IPR001214:SET domain,IPR002110:Ankyrin repeat,IPR007728:Pre-SET domain,IPR020683:Ankyrin repeat-containing domain, hsa00310:Lysine degradation, 610253~Kleefstra syndrome, SM00248:ANK,SM00317:SET,SM00468:PreSET, 3D-structure,Alternative splicing,ANK repeat,Chromatin regulator,Chromosome,Complete proteome,Disease mutation,Isopeptide bond,Membrane,Mental retardation,Metal-binding,Methyltransferase,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,S-adenosyl-L-methionine,Transferase,Transmembrane,Transmembrane helix,Ubl conjugation,Zinc, binding site:S-adenosyl-L-methionine,binding site:S-adenosyl-L-methionine; via amide nitrogen,chain:Histone-lysine N-methyltransferase, H3 lysine-9 specific 5,compositionally biased region:Poly-Ala,compositionally biased region:Poly-Arg,compositionally biased region:Poly-Glu,domain:Pre-SET,domain:SET,helix,metal ion-binding site:Zinc 1,metal ion-binding site:Zinc 2,metal ion-binding site:Zinc 3,metal ion-binding site:Zinc 4,modified residue,region of interest:S-adenosyl-L-methionine binding,repeat:ANK 1,repeat:ANK 2,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5,repeat:ANK 6,repeat:ANK 7,repeat:ANK 8,sequence conflict,sequence variant,splice variant,strand,turn, P57772 eukaryotic elongation factor, selenocysteine-tRNA specific(EEFSEC) Homo sapiens GO:0001514~selenocysteine incorporation,GO:0006412~translation, GO:0005622~intracellular,GO:0005634~nucleus,GO:0005739~mitochondrion,GO:0030529~intracellular ribonucleoprotein complex, GO:0000049~tRNA binding,GO:0003746~translation elongation factor activity,GO:0003924~GTPase activity,GO:0005525~GTP binding,GO:0035368~selenocysteine insertion sequence binding,GO:0043021~ribonucleoprotein complex binding, IPR000795:Elongation factor, GTP-binding domain,IPR009000:Translation elongation/initiation factor/Ribosomal, beta-barrel,IPR027417:P-loop containing nucleoside triphosphate hydrolase, Alternative splicing,Complete proteome,Cytoplasm,GTP-binding,Methylation,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Protein biosynthesis,Proteomics identification,Reference proteome, chain:Selenocysteine-specific elongation factor,nucleotide phosphate-binding region:GTP,sequence conflict,sequence variant,short sequence motif:Nuclear localization signal, P70531 eukaryotic elongation factor-2 kinase(Eef2k) Rattus norvegicus General function prediction only, GO:0002931~response to ischemia,GO:0031952~regulation of protein autophosphorylation,GO:0032869~cellular response to insulin stimulus,GO:0043066~negative regulation of apoptotic process,GO:0045807~positive regulation of endocytosis,GO:0046777~protein autophosphorylation,GO:0051965~positive regulation of synapse assembly,GO:0061003~positive regulation of dendritic spine morphogenesis,GO:0071277~cellular response to calcium ion,GO:0071320~cellular response to cAMP,GO:0071454~cellular response to anoxia,GO:1990416~cellular response to brain-derived neurotrophic factor stimulus,GO:1990637~response to prolactin, GO:0005737~cytoplasm,GO:0014069~postsynaptic density, GO:0003746~translation elongation factor activity,GO:0004686~elongation factor-2 kinase activity,GO:0005509~calcium ion binding,GO:0005516~calmodulin binding,GO:0005524~ATP binding, IPR004166:MHCK/EF2 kinase,IPR006597:Sel1-like,IPR011009:Protein kinase-like domain,IPR011990:Tetratricopeptide-like helical,IPR017400:Elongation factor 2 kinase, rno04152:AMPK signaling pathway,rno04921:Oxytocin signaling pathway, PIRSF038139:elongation factor 2 kinase, SM00811:Alpha_kinase, Acetylation,ATP-binding,Calcium,Calmodulin-binding,Complete proteome,Elongation factor,Kinase,Nucleotide-binding,Phosphoprotein,Protein biosynthesis,Reference proteome,Serine/threonine-protein kinase,Transferase, chain:Eukaroytic elongation factor 2 kinase,domain:Alpha-type protein kinase,modified residue,nucleotide phosphate-binding region:ATP,region of interest:Calmodulin-binding,region of interest:Pseudosubstrate/autoinhibitory domain, Q92005 eukaryotic translation elongation factor 1 alpha 1, like 1(eef1a1l1) Danio rerio GO:0006412~translation,GO:0006414~translational elongation, GO:0005622~intracellular,GO:0005737~cytoplasm, GO:0000166~nucleotide binding,GO:0003746~translation elongation factor activity,GO:0003924~GTPase activity,GO:0005525~GTP binding, IPR000795:Elongation factor, GTP-binding domain,IPR004160:Translation elongation factor EFTu/EF1A, C-terminal,IPR004161:Translation elongation factor EFTu/EF1A, domain 2,IPR004539:Translation elongation factor EF1A, eukaryotic/archaeal,IPR009000:Translation elongation/initiation factor/Ribosomal, beta-barrel,IPR009001:Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal,IPR027417:P-loop containing nucleoside triphosphate hydrolase, dre03013:RNA transport, Complete proteome,Cytoplasm,Elongation factor,GTP-binding,Nucleotide-binding,Phosphoprotein,Protein biosynthesis,Proteomics identification,Reference proteome, binding site:Glycerylphosphorylethanolamine (covalent),chain:Elongation factor 1-alpha,nucleotide phosphate-binding region:GTP, Q6ZWX6 eukaryotic translation initiation factor 2, subunit 1 alpha(Eif2s1) Mus musculus m_chemicalPathway:Apoptotic Signaling in Response to DNA Damage,m_eif2Pathway:Regulation of eIF2,m_eifPathway:Eukaryotic protein translation,m_igf1mtorPathway:Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway,m_rnaPathway:Double Stranded RNA Induced Gene Expression, Translation, ribosomal structure and biogenesis, GO:0002230~positive regulation of defense response to virus by host,GO:0006412~translation,GO:0006413~translational initiation,GO:0006417~regulation of translation,GO:0007568~aging,GO:0032057~negative regulation of translational initiation in response to stress,GO:0034198~cellular response to amino acid starvation,GO:0034605~cellular response to heat,GO:0034644~cellular response to UV,GO:0034976~response to endoplasmic reticulum stress,GO:0043558~regulation of translational initiation in response to stress,GO:0046777~protein autophosphorylation,GO:0098779~mitophagy in response to mitochondrial depolarization,GO:0098792~xenophagy,GO:1901216~positive regulation of neuron death,GO:1905098~negative regulation of guanyl-nucleotide exchange factor activity,GO:1990737~response to manganese-induced endoplasmic reticulum stress,GO:2000676~positive regulation of type B pancreatic cell apoptotic process, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005840~ribosome,GO:0005850~eukaryotic translation initiation factor 2 complex,GO:0005851~eukaryotic translation initiation factor 2B complex,GO:0010494~cytoplasmic stress granule,GO:0016020~membrane,GO:0033290~eukaryotic 48S preinitiation complex,GO:0043614~multi-eIF complex,GO:0044207~translation initiation ternary complex,GO:0070062~extracellular exosome,GO:0097451~glial limiting end-foot, GO:0003676~nucleic acid binding,GO:0003723~RNA binding,GO:0003743~translation initiation factor activity,GO:0005515~protein binding,GO:0043022~ribosome binding,GO:0044822~poly(A) RNA binding, IPR003029:Ribosomal protein S1, RNA-binding domain,IPR011488:Translation initiation factor 2, alpha subunit,IPR012340:Nucleic acid-binding, OB-fold,IPR022967:RNA-binding domain, S1,IPR024054:Translation initiation factor 2, alpha subunit, middle domain,IPR024055:Translation initiation factor 2, alpha subunit, C-terminal, mmu03013:RNA transport,mmu04141:Protein processing in endoplasmic reticulum,mmu04932:Non-alcoholic fatty liver disease (NAFLD),mmu05160:Hepatitis C,mmu05162:Measles,mmu05164:Influenza A,mmu05168:Herpes simplex infection, SM00316:SM00316, Acetylation,Coiled coil,Complete proteome,Initiation factor,Phosphoprotein,Protein biosynthesis,Reference proteome,RNA-binding,Translation regulation, chain:Eukaryotic translation initiation factor 2 subunit 1,domain:S1 motif,modified residue, F1QGW6 eukaryotic translation initiation factor 2, subunit 3 gamma(eif2s3) Danio rerio GO:0001731~formation of translation preinitiation complex,GO:0006412~translation,GO:0006413~translational initiation, GO:0005622~intracellular, GO:0003743~translation initiation factor activity,GO:0003924~GTPase activity,GO:0005525~GTP binding, IPR000795:Elongation factor, GTP-binding domain,IPR004161:Translation elongation factor EFTu/EF1A, domain 2,IPR009000:Translation elongation/initiation factor/Ribosomal, beta-barrel,IPR009001:Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal,IPR015256:Translation initiation factor 2, gamma subunit, C-terminal,IPR027417:P-loop containing nucleoside triphosphate hydrolase, dre03013:RNA transport, Complete proteome,Initiation factor,Protein biosynthesis,Proteomics identification,Reference proteome, A2VD00 eukaryotic translation initiation factor 3 subunit A S homeolog(eif3a.S) Xenopus laevis DNA replication, recombination, and repair, GO:0001731~formation of translation preinitiation complex,GO:0001732~formation of cytoplasmic translation initiation complex,GO:0006446~regulation of translational initiation, GO:0005852~eukaryotic translation initiation factor 3 complex,GO:0016282~eukaryotic 43S preinitiation complex,GO:0033290~eukaryotic 48S preinitiation complex, GO:0003743~translation initiation factor activity, IPR000717:Proteasome component (PCI) domain,IPR027512:Eukaryotic translation initiation factor 3 subunit A, xla03013:RNA transport, SM00088:PINT, Cytoplasm,Initiation factor,Protein biosynthesis,Repeat,RNA-binding, chain:Eukaryotic translation initiation factor 3 subunit A,compositionally biased region:Asp-rich,compositionally biased region:Glu-rich,domain:PCI,region of interest:26 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[GTV]-[PS]-R-R-G- [AFGLM],repeat:10; approximate,repeat:11,repeat:12,repeat:13,repeat:14,repeat:15,repeat:16,repeat:17,repeat:18,repeat:19,repeat:1; approximate,repeat:2,repeat:20,repeat:21,repeat:22; approximate,repeat:23,repeat:24,repeat:25,repeat:26,repeat:3,repeat:4,repeat:5,repeat:6,repeat:7,repeat:8,repeat:9, P55884 eukaryotic translation initiation factor 3 subunit B(EIF3B) Homo sapiens General function prediction only, GO:0001731~formation of translation preinitiation complex,GO:0006413~translational initiation,GO:0006446~regulation of translational initiation,GO:0075522~IRES-dependent viral translational initiation,GO:0075525~viral translational termination-reinitiation, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005852~eukaryotic translation initiation factor 3 complex,GO:0016282~eukaryotic 43S preinitiation complex,GO:0033290~eukaryotic 48S preinitiation complex,GO:0070062~extracellular exosome,GO:0071541~eukaryotic translation initiation factor 3 complex, eIF3m, GO:0000166~nucleotide binding,GO:0003723~RNA binding,GO:0003743~translation initiation factor activity,GO:0005515~protein binding,GO:0031369~translation initiation factor binding,GO:0032947~protein complex scaffold, IPR000504:RNA recognition motif domain,IPR011042:Six-bladed beta-propeller, TolB-like,IPR011400:Eukaryotic translation initiation factor 3 subunit B,IPR012677:Nucleotide-binding, alpha-beta plait,IPR013979:Translation initiation factor, beta propellor-like domain,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain, hsa03013:RNA transport, PIRSF036424:translation initiation factor eIF-3b, SM00360:RRM, 3D-structure,Acetylation,Alternative splicing,Complete proteome,Cytoplasm,Initiation factor,Phosphoprotein,Polymorphism,Protein biosynthesis,Proteomics identification,Reference proteome,Repeat,RNA-binding,WD repeat, chain:Eukaryotic translation initiation factor 3 subunit B,domain:RRM,helix,modified residue,region of interest:Sufficient for interaction with EIF3E,region of interest:Sufficient for interaction with EIF3J,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,sequence conflict,sequence variant,splice variant,strand,turn, Q747K3 excinuclease ABC subunit B(uvrB) Geobacter sulfurreducens PCA GO:0006281~DNA repair,GO:0006289~nucleotide-excision repair,GO:0009432~SOS response, GO:0005737~cytoplasm,GO:0009380~excinuclease repair complex, GO:0003677~DNA binding,GO:0004386~helicase activity,GO:0005524~ATP binding,GO:0009381~excinuclease ABC activity, IPR001650:Helicase, C-terminal,IPR001943:UVR domain,IPR004807:UvrABC system, subunit B,IPR006935:Helicase/UvrB domain,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR024759:UvrB, YAD/RRR-motif-containing domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, gsu03420:Nucleotide excision repair, SM00487:DEXDc,SM00490:HELICc, ATP-binding,Complete proteome,Cytoplasm,DNA damage,DNA excision,DNA repair,Excision nuclease,Nucleotide-binding,Reference proteome,SOS response, chain:UvrABC system protein B,domain:Helicase ATP-binding,domain:Helicase C-terminal,domain:UVR,nucleotide phosphate-binding region:ATP,short sequence motif:Beta-hairpin, A2BGR3 excision repair cross-complementation group 6-like(ercc6l) Danio rerio GO:0007049~cell cycle,GO:0007067~mitotic nuclear division,GO:0016539~intein-mediated protein splicing,GO:0051301~cell division, GO:0000775~chromosome, centromeric region,GO:0000776~kinetochore,GO:0000777~condensed chromosome kinetochore,GO:0005694~chromosome, GO:0000166~nucleotide binding,GO:0003677~DNA binding,GO:0004386~helicase activity,GO:0005524~ATP binding,GO:0016787~hydrolase activity, IPR000330:SNF2-related,IPR001650:Helicase, C-terminal,IPR006141:Intein splice site,IPR011990:Tetratricopeptide-like helical,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR019734:Tetratricopeptide repeat,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00487:DEXDc,SM00490:HELICc, ATP-binding,Cell cycle,Cell division,Centromere,Chromosome,Complete proteome,DNA-binding,Helicase,Hydrolase,Kinetochore,Mitosis,Nucleotide-binding,Phosphoprotein,Reference proteome,Repeat,TPR repeat, chain:DNA excision repair protein ERCC-6-like,compositionally biased region:Glu-rich,domain:Helicase ATP-binding,domain:Helicase C-terminal,modified residue,nucleotide phosphate-binding region:ATP,repeat:TPR 1,repeat:TPR 2,sequence conflict,short sequence motif:DEAH box, Q9Y3B2 exosome component 1(EXOSC1) Homo sapiens Translation, ribosomal structure and biogenesis, GO:0006364~rRNA processing,GO:0043488~regulation of mRNA stability,GO:0043928~exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay, GO:0000176~nuclear exosome (RNase complex),GO:0000178~exosome (RNase complex),GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0003723~RNA binding,GO:0004532~exoribonuclease activity,GO:0005515~protein binding, IPR012340:Nucleic acid-binding, OB-fold,IPR019495:Exosome complex component CSL4,IPR022967:RNA-binding domain, S1,IPR025721:Exosome complex component, N-terminal domain, hsa03018:RNA degradation, SM00316:SM00316, 3D-structure,Complete proteome,Cytoplasm,Exosome,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,RNA-binding,rRNA processing, chain:3'-5' exoribonuclease CSL4 homolog,domain:S1 motif,helix,modified residue,strand,turn, Q5ZLT0 exportin 7(XPO7) Gallus gallus Nuclear structure / Intracellular trafficking and secretion, GO:0006611~protein export from nucleus, GO:0005643~nuclear pore,GO:0005737~cytoplasm, GO:0005049~nuclear export signal receptor activity,GO:0008536~Ran GTPase binding, IPR001494:Importin-beta, N-terminal,IPR016024:Armadillo-type fold, SM00913:SM00913, Complete proteome,Cytoplasm,Nucleus,Protein transport,Reference proteome,Transport, chain:Exportin-7,domain:Importin N-terminal, Q6NZK5 expressed sequence AW554918(AW554918) Mus musculus Alternative splicing,Coiled coil,Complete proteome,Phosphoprotein,Proteomics identification,Reference proteome, chain:Uncharacterized protein KIAA1328,modified residue,splice variant, Q3TZZ7 extended synaptotagmin-like protein 2(Esyt2) Mus musculus General function prediction only, GO:0006810~transport,GO:0006869~lipid transport,GO:0006897~endocytosis,GO:0098609~cell-cell adhesion, GO:0005783~endoplasmic reticulum,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0005913~cell-cell adherens junction,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0031227~intrinsic component of endoplasmic reticulum membrane,GO:0031234~extrinsic component of cytoplasmic side of plasma membrane,GO:0044232~organelle membrane contact site, GO:0005509~calcium ion binding,GO:0005544~calcium-dependent phospholipid binding,GO:0008289~lipid binding,GO:0008429~phosphatidylethanolamine binding,GO:0031210~phosphatidylcholine binding,GO:0035091~phosphatidylinositol binding,GO:0042802~identical protein binding,GO:0046872~metal ion binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000008:C2 calcium-dependent membrane targeting, SM00239:C2, Alternative splicing,Calcium,Cell membrane,Complete proteome,Endocytosis,Endoplasmic reticulum,Lipid transport,Lipid-binding,Membrane,Metal-binding,Phosphoprotein,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Transport, chain:Extended synaptotagmin-2,compositionally biased region:Poly-Ser,domain:C2 1,domain:C2 2,domain:C2 3,modified residue,splice variant,transmembrane region, Q2KI00 family with sequence similarity 107 member B(FAM107B) Bos taurus GO:0007605~sensory perception of sound, IPR009533:Protein of unknown function DUF1151, Acetylation,Coiled coil,Complete proteome,Reference proteome, chain:Protein FAM107B,modified residue, A1L253 family with sequence similarity 149, member B1(fam149b1) Danio rerio IPR022194:Protein of unknown function DUF3719, Complete proteome,Reference proteome, chain:Protein FAM149B1, Q6UXP7 family with sequence similarity 151 member B(FAM151B) Homo sapiens GO:0005515~protein binding, IPR019356:Protein of unknown function DUF2181, Complete proteome,Polymorphism,Proteomics identification,Reference proteome, chain:Protein FAM151B,sequence variant, Q5W0V3 family with sequence similarity 160 member B1(FAM160B1) Homo sapiens IPR019384:Retinoic acid induced 16-like protein, Alternative splicing,Complete proteome,Polymorphism,Proteomics identification,Reference proteome, chain:UPF0518 protein FAM160B1,sequence conflict,sequence variant,splice variant, Q66KE9 family with sequence similarity 161 member A L homeolog(fam161a.L) Xenopus laevis GO:0030030~cell projection organization, GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005929~cilium, IPR019579:Uncharacterised protein family UPF0564, Cell projection,Cilium,Cilium biogenesis/degradation,Coiled coil,Cytoplasm,Cytoskeleton, chain:Protein FAM161A, Q8NB25 family with sequence similarity 184 member A(FAM184A) Homo sapiens GO:0005615~extracellular space, GO:0005515~protein binding, Alternative splicing,Coiled coil,Complete proteome,Polymorphism,Proteomics identification,Reference proteome, chain:Protein FAM184A,sequence conflict,sequence variant,splice variant, Q5R939 family with sequence similarity 204 member A(FAM204A) Pongo abelii Coiled coil,Complete proteome,Reference proteome, chain:Uncharacterized protein C10orf84 homolog, Q5ZML6 family with sequence similarity 210 member A(FAM210A) Gallus gallus GO:0005739~mitochondrion,GO:0016021~integral component of membrane, IPR009688:Domain of unknown function DUF1279, Coiled coil,Complete proteome,Membrane,Mitochondrion,Reference proteome,Transmembrane,Transmembrane helix, chain:Uncharacterized protein C18orf19 homolog,domain:DUF1279,transmembrane region, Q5ZKN5 family with sequence similarity 53 member A(FAM53A) Gallus gallus GO:0006606~protein import into nucleus, GO:0005634~nucleus, Complete proteome,Nucleus,Reference proteome, chain:Protein FAM53A,sequence conflict,short sequence motif:Nuclear localization signal, Q5F3L9 family with sequence similarity 65, member B(FAM65B) Gallus gallus GO:0007605~sensory perception of sound,GO:0048741~skeletal muscle fiber development, GO:0005737~cytoplasm,GO:0060171~stereocilium membrane, IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold,IPR026136:Protein FAM65, Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Hearing,Membrane,Reference proteome, chain:Protein FAM65B,region of interest:Interacts with NCAM, Q80U16 family with sequence similarity 65, member B(Fam65b) Mus musculus GO:0007605~sensory perception of sound,GO:0048741~skeletal muscle fiber development, GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016324~apical plasma membrane,GO:0042995~cell projection,GO:0060171~stereocilium membrane, GO:0005515~protein binding, IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold,IPR026136:Protein FAM65, Alternative splicing,Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Hearing,Membrane,Phosphoprotein,Proteomics identification,Reference proteome, chain:Protein FAM65B,modified residue,sequence conflict,splice variant, Q8TBF8 family with sequence similarity 81 member A(FAM81A) Homo sapiens Coiled coil,Complete proteome,Proteomics identification,Reference proteome, chain:Protein FAM81A, Q3UXZ6 family with sequence similarity 81, member A(Fam81a) Mus musculus Coiled coil,Complete proteome,Proteomics identification,Reference proteome, chain:Protein FAM81A,sequence conflict, Q1RMK1 family with sequence similarity 92 member B(FAM92B) Bos taurus IPR009602:FAM92 protein,IPR027267:Arfaptin homology (AH) domain/BAR domain, Complete proteome,Reference proteome, chain:Protein FAM92B, Q32PX7 far upstream element binding protein 1(Fubp1) Rattus norvegicus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0010628~positive regulation of gene expression,GO:0016049~cell growth,GO:0017145~stem cell division,GO:0071425~hematopoietic stem cell proliferation, GO:0005634~nucleus,GO:0005654~nucleoplasm, GO:0001205~transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding,GO:0003677~DNA binding,GO:0003723~RNA binding,GO:0044822~poly(A) RNA binding, IPR004087:K Homology domain,IPR004088:K Homology domain, type 1,IPR015096:Domain of unknown function DUF1897, SM00322:KH, Acetylation,Complete proteome,DNA-binding,Methylation,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,Ubl conjugation, chain:Far upstream element-binding protein 1,compositionally biased region:Poly-Gly,compositionally biased region:Pro-rich,domain:KH 1,domain:KH 2,domain:KH 3,domain:KH 4,modified residue, Q96I24 far upstream element binding protein 3(FUBP3) Homo sapiens GO:0006351~transcription, DNA-templated,GO:0006366~transcription from RNA polymerase II promoter,GO:0010628~positive regulation of gene expression,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0016020~membrane, GO:0000978~RNA polymerase II core promoter proximal region sequence-specific DNA binding,GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding,GO:0003723~RNA binding,GO:0005515~protein binding,GO:0044822~poly(A) RNA binding, IPR004087:K Homology domain,IPR004088:K Homology domain, type 1, SM00322:KH, Acetylation,Alternative splicing,Complete proteome,Direct protein sequencing,DNA-binding,Isopeptide bond,Nucleus,Phosphoprotein,Reference proteome,Repeat,Transcription,Transcription regulation,Ubl conjugation, chain:Far upstream element-binding protein 3,domain:KH 1,domain:KH 2,domain:KH 3,domain:KH 4,modified residue,sequence conflict,splice variant, Q6GMR7 fatty acid amide hydrolase 2(FAAH2) Homo sapiens Translation, ribosomal structure and biogenesis, GO:0019369~arachidonic acid metabolic process, GO:0005811~lipid particle,GO:0016021~integral component of membrane, GO:0004040~amidase activity,GO:0016787~hydrolase activity,GO:0016884~carbon-nitrogen ligase activity, with glutamine as amido-N-donor,GO:0017064~fatty acid amide hydrolase activity,GO:0103073~anandamide amidohydrolase activity, IPR000120:Amidase,IPR020556:Amidase, conserved site,IPR023631:Amidase signature domain, Coiled coil,Complete proteome,Hydrolase,Membrane,Reference proteome,Transmembrane,Transmembrane helix, active site:Acyl-ester intermediate,active site:Charge relay system,chain:Fatty-acid amide hydrolase 2,compositionally biased region:Poly-Leu,sequence conflict,transmembrane region, A2VE15 fatty acid desaturase 6(FADS6) Bos taurus GO:0006633~fatty acid biosynthetic process,GO:0055114~oxidation-reduction process, GO:0016021~integral component of membrane, GO:0016491~oxidoreductase activity, IPR005804:Fatty acid desaturase, type 1, Complete proteome,Fatty acid biosynthesis,Fatty acid metabolism,Lipid biosynthesis,Lipid metabolism,Membrane,Oxidoreductase,Reference proteome,Transmembrane,Transmembrane helix, chain:Fatty acid desaturase 6,short sequence motif:Histidine box-1,short sequence motif:Histidine box-2,short sequence motif:Histidine box-3,transmembrane region, P12276 fatty acid synthase(FASN) Gallus gallus Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism, GO:0001649~osteoblast differentiation,GO:0006089~lactate metabolic process,GO:0006633~fatty acid biosynthetic process,GO:0009058~biosynthetic process,GO:0032100~positive regulation of appetite,GO:0055114~oxidation-reduction process,GO:0071353~cellular response to interleukin-4, GO:0005623~cell,GO:0005739~mitochondrion,GO:0005794~Golgi apparatus,GO:0005886~plasma membrane,GO:0042587~glycogen granule,GO:0070062~extracellular exosome, GO:0003697~single-stranded DNA binding,GO:0004312~fatty acid synthase activity,GO:0004313~[acyl-carrier-protein] S-acetyltransferase activity,GO:0004314~[acyl-carrier-protein] S-malonyltransferase activity,GO:0004315~3-oxoacyl-[acyl-carrier-protein] synthase activity,GO:0004316~3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity,GO:0004317~3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity,GO:0004319~enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity,GO:0004320~oleoyl-[acyl-carrier-protein] hydrolase activity,GO:0016295~myristoyl-[acyl-carrier-protein] hydrolase activity,GO:0016296~palmitoyl-[acyl-carrier-protein] hydrolase activity,GO:0017150~tRNA dihydrouridine synthase activity,GO:0031177~phosphopantetheine binding,GO:0044822~poly(A) RNA binding,GO:0047117~enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity,GO:0047451~3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity,GO:0050660~flavin adenine dinucleotide binding,GO:0102132~3-oxo-pimeloyl-[acp] methyl ester reductase activity, IPR001031:Thioesterase,IPR001227:Acyl transferase domain,IPR001269:tRNA-dihydrouridine synthase,IPR006162:Phosphopantetheine attachment site,IPR009081:Acyl carrier protein-like,IPR011032:GroES-like,IPR013149:Alcohol dehydrogenase, C-terminal,IPR013785:Aldolase-type TIM barrel,IPR013968:Polyketide synthase, KR,IPR014030:Beta-ketoacyl synthase, N-terminal,IPR014031:Beta-ketoacyl synthase, C-terminal,IPR014043:Acyl transferase,IPR016035:Acyl transferase/acyl hydrolase/lysophospholipase,IPR016036:Malonyl-CoA ACP transacylase, ACP-binding,IPR016039:Thiolase-like,IPR016040:NAD(P)-binding domain,IPR018201:Beta-ketoacyl synthase, active site,IPR018517:tRNA-dihydrouridine synthase, conserved site,IPR020801:Polyketide synthase, acyl transferase domain,IPR020806:Polyketide synthase, phosphopantetheine-binding domain,IPR020807:Polyketide synthase, dehydratase domain,IPR020841:Polyketide synthase, beta-ketoacyl synthase domain,IPR020843:Polyketide synthase, enoylreductase,IPR023102:Fatty acid synthase, domain 2, gga00061:Fatty acid biosynthesis,gga01100:Metabolic pathways,gga01212:Fatty acid metabolism,gga04910:Insulin signaling pathway, SM00823:SM00823,SM00825:SM00825,SM00826:SM00826,SM00827:SM00827,SM00829:SM00829, Acetylation,Alternative splicing,Complete proteome,Direct protein sequencing,Fatty acid biosynthesis,Fatty acid metabolism,Hydrolase,Lipid biosynthesis,Lipid metabolism,Lyase,Multifunctional enzyme,NAD,NADP,Oxidoreductase,Phosphopantetheine,Phosphoprotein,Pyridoxal phosphate,Reference proteome,Transferase, active site:For acyl/malonyl transferase activity,active site:For beta-hydroxyacyl dehydratase activity,active site:For beta-ketoacyl synthase activity,active site:For thioesterase activity,chain:Fatty acid synthase,domain:Acyl carrier,modified residue,nucleotide phosphate-binding region:NADP (ER),nucleotide phosphate-binding region:NADP (KR),region of interest:Acyl and malonyl transferases,region of interest:Beta-ketoacyl reductase,region of interest:Beta-ketoacyl synthase,region of interest:Enoyl reductase,region of interest:Thioesterase,sequence conflict,splice variant, Q9JJN1 fibroblast growth factor 21(Fgf21) Mus musculus GO:0008284~positive regulation of cell proliferation,GO:0008543~fibroblast growth factor receptor signaling pathway,GO:0010898~positive regulation of triglyceride catabolic process,GO:0014823~response to activity,GO:0030968~endoplasmic reticulum unfolded protein response,GO:0031667~response to nutrient levels,GO:0035690~cellular response to drug,GO:0046326~positive regulation of glucose import,GO:0070374~positive regulation of ERK1 and ERK2 cascade,GO:0071333~cellular response to glucose stimulus,GO:0071377~cellular response to glucagon stimulus,GO:0071404~cellular response to low-density lipoprotein particle stimulus,GO:0072577~endothelial cell apoptotic process,GO:0090080~positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway,GO:1901215~negative regulation of neuron death,GO:1904640~response to methionine,GO:2000352~negative regulation of endothelial cell apoptotic process, GO:0005576~extracellular region,GO:0005615~extracellular space,GO:0005623~cell, GO:0005102~receptor binding,GO:0005104~fibroblast growth factor receptor binding,GO:0008083~growth factor activity, IPR002209:Heparin-binding growth factor/Fibroblast growth factor,IPR008996:Cytokine, IL-1-like, mmu04010:MAPK signaling pathway,mmu04014:Ras signaling pathway,mmu04015:Rap1 signaling pathway,mmu04151:PI3K-Akt signaling pathway,mmu04810:Regulation of actin cytoskeleton,mmu05200:Pathways in cancer,mmu05218:Melanoma, SM00442:FGF, Complete proteome,Growth factor,Reference proteome,Secreted,Signal, chain:Fibroblast growth factor 21,signal peptide, P07589 fibronectin 1(FN1) Bos taurus GO:0001525~angiogenesis,GO:0006953~acute-phase response,GO:0007044~cell-substrate junction assembly,GO:0007155~cell adhesion,GO:0007161~calcium-independent cell-matrix adhesion,GO:0008360~regulation of cell shape,GO:0010628~positive regulation of gene expression,GO:0018149~peptide cross-linking,GO:0033622~integrin activation,GO:0034446~substrate adhesion-dependent cell spreading,GO:0035987~endodermal cell differentiation,GO:0042060~wound healing,GO:0045773~positive regulation of axon extension,GO:0048146~positive regulation of fibroblast proliferation,GO:0070372~regulation of ERK1 and ERK2 cascade,GO:1904237~positive regulation of substrate-dependent cell migration, cell attachment to substrate,GO:2001202~negative regulation of transforming growth factor-beta secretion, GO:0005576~extracellular region,GO:0005577~fibrinogen complex,GO:0005578~proteinaceous extracellular matrix,GO:0005605~basal lamina,GO:0005793~endoplasmic reticulum-Golgi intermediate compartment,GO:0016324~apical plasma membrane,GO:0070062~extracellular exosome,GO:0072562~blood microparticle, GO:0005515~protein binding,GO:0008201~heparin binding,GO:0016504~peptidase activator activity, IPR000083:Fibronectin, type I,IPR000562:Fibronectin, type II, collagen-binding,IPR003961:Fibronectin, type III,IPR013783:Immunoglobulin-like fold,IPR013806:Kringle-like fold, bta04151:PI3K-Akt signaling pathway,bta04510:Focal adhesion,bta04512:ECM-receptor interaction,bta04810:Regulation of actin cytoskeleton,bta05100:Bacterial invasion of epithelial cells,bta05146:Amoebiasis,bta05200:Pathways in cancer,bta05205:Proteoglycans in cancer,bta05222:Small cell lung cancer, SM00058:FN1,SM00059:FN2,SM00060:FN3, Acute phase,Alternative splicing,Angiogenesis,Cell adhesion,Cell shape,Complete proteome,Direct protein sequencing,Disulfide bond,Extracellular matrix,Glycoprotein,Heparin-binding,Isopeptide bond,Phosphoprotein,Proteomics identification,Pyrrolidone carboxylic acid,Reference proteome,Repeat,Secreted,Signal,Sulfation, chain:Anastellin,chain:Fibronectin,cross-link:Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?),disulfide bond,domain:Fibronectin type-I 1,domain:Fibronectin type-I 10,domain:Fibronectin type-I 11,domain:Fibronectin type-I 12,domain:Fibronectin type-I 2,domain:Fibronectin type-I 3,domain:Fibronectin type-I 4,domain:Fibronectin type-I 5,domain:Fibronectin type-I 6,domain:Fibronectin type-I 7,domain:Fibronectin type-I 8,domain:Fibronectin type-I 9,domain:Fibronectin type-II 1,domain:Fibronectin type-II 2,domain:Fibronectin type-III 1,domain:Fibronectin type-III 10,domain:Fibronectin type-III 11,domain:Fibronectin type-III 12,domain:Fibronectin type-III 13; extra domain 2,domain:Fibronectin type-III 14,domain:Fibronectin type-III 15,domain:Fibronectin type-III 16,domain:Fibronectin type-III 17,domain:Fibronectin type-III 2,domain:Fibronectin type-III 3,domain:Fibronectin type-III 4,domain:Fibronectin type-III 5,domain:Fibronectin type-III 6,domain:Fibronectin type-III 7,domain:Fibronectin type-III 8; extra domain 1,domain:Fibronectin type-III 9,glycosylation site:N-linked (GlcNAc...),glycosylation site:O-linked (GalNAc...),modified residue,region of interest:Cell-attachment,region of interest:Collagen-binding,region of interest:Connecting strand 3 (CS-3) (V region),region of interest:Fibrin- and heparin-binding 1,region of interest:Fibrin-binding 2,region of interest:Heparin-binding 2,short sequence motif:Cell attachment site,signal peptide, P04937 fibronectin 1(Fn1) Rattus norvegicus GO:0001503~ossification,GO:0001525~angiogenesis,GO:0001775~cell activation,GO:0001932~regulation of protein phosphorylation,GO:0002931~response to ischemia,GO:0006953~acute-phase response,GO:0007044~cell-substrate junction assembly,GO:0007155~cell adhesion,GO:0007160~cell-matrix adhesion,GO:0007161~calcium-independent cell-matrix adhesion,GO:0008284~positive regulation of cell proliferation,GO:0008347~glial cell migration,GO:0008360~regulation of cell shape,GO:0009611~response to wounding,GO:0010039~response to iron ion,GO:0010193~response to ozone,GO:0010628~positive regulation of gene expression,GO:0010952~positive regulation of peptidase activity,GO:0014823~response to activity,GO:0018149~peptide cross-linking,GO:0030198~extracellular matrix organization,GO:0030335~positive regulation of cell migration,GO:0033622~integrin activation,GO:0034446~substrate adhesion-dependent cell spreading,GO:0035924~cellular response to vascular endothelial growth factor stimulus,GO:0035987~endodermal cell differentiation,GO:0036120~cellular response to platelet-derived growth factor stimulus,GO:0042060~wound healing,GO:0042493~response to drug,GO:0043066~negative regulation of apoptotic process,GO:0045773~positive regulation of axon extension,GO:0048146~positive regulation of fibroblast proliferation,GO:0050921~positive regulation of chemotaxis,GO:0051384~response to glucocorticoid,GO:0070372~regulation of ERK1 and ERK2 cascade,GO:0071222~cellular response to lipopolysaccharide,GO:0071288~cellular response to mercury ion,GO:0071333~cellular response to glucose stimulus,GO:0071347~cellular response to interleukin-1,GO:0071380~cellular response to prostaglandin E stimulus,GO:0071560~cellular response to transforming growth factor beta stimulus,GO:0071773~cellular response to BMP stimulus,GO:1904237~positive regulation of substrate-dependent cell migration, cell attachment to substrate,GO:1904385~cellular response to angiotensin,GO:1904646~cellular response to beta-amyloid,GO:2001202~negative regulation of transforming growth factor-beta secretion, GO:0005576~extracellular region,GO:0005577~fibrinogen complex,GO:0005578~proteinaceous extracellular matrix,GO:0005604~basement membrane,GO:0005605~basal lamina,GO:0005615~extracellular space,GO:0005793~endoplasmic reticulum-Golgi intermediate compartment,GO:0016324~apical plasma membrane,GO:0031012~extracellular matrix,GO:0070062~extracellular exosome,GO:0072562~blood microparticle, GO:0002020~protease binding,GO:0005178~integrin binding,GO:0005201~extracellular matrix structural constituent,GO:0005515~protein binding,GO:0008201~heparin binding,GO:0016504~peptidase activator activity,GO:0042802~identical protein binding,GO:0045340~mercury ion binding, IPR000083:Fibronectin, type I,IPR000562:Fibronectin, type II, collagen-binding,IPR003961:Fibronectin, type III,IPR013783:Immunoglobulin-like fold,IPR013806:Kringle-like fold, rno04151:PI3K-Akt signaling pathway,rno04510:Focal adhesion,rno04512:ECM-receptor interaction,rno04810:Regulation of actin cytoskeleton,rno05100:Bacterial invasion of epithelial cells,rno05146:Amoebiasis,rno05200:Pathways in cancer,rno05205:Proteoglycans in cancer,rno05222:Small cell lung cancer, SM00058:FN1,SM00059:FN2,SM00060:FN3, Acute phase,Alternative splicing,Angiogenesis,Cell adhesion,Cell shape,Complete proteome,Direct protein sequencing,Disulfide bond,Extracellular matrix,Glycoprotein,Heparin-binding,Isopeptide bond,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Secreted,Signal,Sulfation, chain:Anastellin,chain:Fibronectin,cross-link:Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?),disulfide bond,domain:Fibronectin type-I 1,domain:Fibronectin type-I 10,domain:Fibronectin type-I 11,domain:Fibronectin type-I 12,domain:Fibronectin type-I 2,domain:Fibronectin type-I 3,domain:Fibronectin type-I 4,domain:Fibronectin type-I 5,domain:Fibronectin type-I 6,domain:Fibronectin type-I 7,domain:Fibronectin type-I 8,domain:Fibronectin type-I 9,domain:Fibronectin type-II 1,domain:Fibronectin type-II 2,domain:Fibronectin type-III 1,domain:Fibronectin type-III 10,domain:Fibronectin type-III 11,domain:Fibronectin type-III 12,domain:Fibronectin type-III 13; extra domain 2,domain:Fibronectin type-III 14,domain:Fibronectin type-III 15,domain:Fibronectin type-III 16,domain:Fibronectin type-III 17,domain:Fibronectin type-III 2,domain:Fibronectin type-III 3,domain:Fibronectin type-III 4,domain:Fibronectin type-III 5,domain:Fibronectin type-III 6,domain:Fibronectin type-III 7,domain:Fibronectin type-III 8; extra domain 1,domain:Fibronectin type-III 9,glycosylation site:N-linked (GlcNAc...),glycosylation site:O-linked (GalNAc...),modified residue,region of interest:Cell-attachment,region of interest:Collagen-binding,region of interest:Connecting strand 3 (CS-3) (V region),region of interest:Fibrin- and heparin-binding 1,region of interest:Fibrin-binding 2,region of interest:Heparin-binding 2,sequence conflict,short sequence motif:Cell attachment site,signal peptide,splice variant, Q8BX90 fibronectin type III domain containing 3A(Fndc3a) Mus musculus GO:0007286~spermatid development,GO:0009566~fertilization,GO:0016337~single organismal cell-cell adhesion,GO:0060009~Sertoli cell development, GO:0000139~Golgi membrane,GO:0001669~acrosomal vesicle,GO:0005794~Golgi apparatus,GO:0005829~cytosol,GO:0012506~vesicle membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0031410~cytoplasmic vesicle, GO:0044822~poly(A) RNA binding, IPR003961:Fibronectin, type III,IPR013783:Immunoglobulin-like fold, SM00060:FN3, Acetylation,Complete proteome,Golgi apparatus,Membrane,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Transmembrane,Transmembrane helix, chain:Fibronectin type-III domain-containing protein 3A,compositionally biased region:Pro-rich,domain:Fibronectin type-III 1,domain:Fibronectin type-III 2,domain:Fibronectin type-III 3,domain:Fibronectin type-III 4,domain:Fibronectin type-III 5,domain:Fibronectin type-III 6,domain:Fibronectin type-III 7,domain:Fibronectin type-III 8,domain:Fibronectin type-III 9,modified residue,sequence conflict,transmembrane region, P10079 fibropellin I(egf1) Strongylocentrotus purpuratus GO:0005615~extracellular space,GO:0016023~cytoplasmic, membrane-bounded vesicle,GO:0032579~apical lamina of hyaline layer, GO:0005509~calcium ion binding, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR000859:CUB domain,IPR001881:EGF-like calcium-binding,IPR005468:Avidin/streptavidin,IPR005469:Avidin,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR013032:EGF-like, conserved site,IPR017889:Avidin-like, conserved site,IPR018097:EGF-like calcium-binding, conserved site, SM00042:CUB,SM00179:EGF_CA,SM00181:EGF, Alternative splicing,Calcium,Complete proteome,Cytoplasmic vesicle,Disulfide bond,EGF-like domain,Extracellular matrix,Glycoprotein,Reference proteome,Repeat,Secreted,Signal, chain:Fibropellin-1,disulfide bond,domain:Avidin-like,domain:CUB,domain:EGF-like 1,domain:EGF-like 10; calcium-binding,domain:EGF-like 11; calcium-binding,domain:EGF-like 12; calcium-binding,domain:EGF-like 13; calcium-binding,domain:EGF-like 14; calcium-binding,domain:EGF-like 15; calcium-binding,domain:EGF-like 16; calcium-binding,domain:EGF-like 17; calcium-binding,domain:EGF-like 18; calcium-binding,domain:EGF-like 19; calcium-binding,domain:EGF-like 20,domain:EGF-like 21; calcium-binding,domain:EGF-like 2; calcium-binding,domain:EGF-like 3; calcium-binding,domain:EGF-like 4; calcium-binding,domain:EGF-like 5; calcium-binding,domain:EGF-like 6; calcium-binding,domain:EGF-like 7; calcium-binding,domain:EGF-like 8; calcium-binding,domain:EGF-like 9; calcium-binding,glycosylation site:N-linked (GlcNAc...),sequence conflict,signal peptide,splice variant, A1L2Y1 fibrous sheath interacting protein 1 L homeolog(fsip1.L) Xenopus laevis IPR026246:Fibrous sheath-interacting protein 1, Coiled coil, Q6DDU8 fidgetin-like 1 L homeolog(fignl1.L) Xenopus laevis Posttranslational modification, protein turnover, chaperones, GO:0046034~ATP metabolic process, GO:0000228~nuclear chromosome, GO:0000287~magnesium ion binding,GO:0005524~ATP binding,GO:0016787~hydrolase activity, IPR003593:AAA+ ATPase domain,IPR003959:ATPase, AAA-type, core,IPR003960:ATPase, AAA-type, conserved site,IPR015415:Vps4 oligomerisation, C-terminal,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00382:AAA, ATP-binding,Hydrolase,Magnesium,Metal-binding,Nucleotide-binding,Nucleus, chain:Fidgetin-like protein 1,nucleotide phosphate-binding region:ATP, P21333 filamin A(FLNA) Homo sapiens GO:0002576~platelet degranulation,GO:0007195~adenylate cyclase-inhibiting dopamine receptor signaling pathway,GO:0016479~negative regulation of transcription from RNA polymerase I promoter,GO:0030168~platelet activation,GO:0030334~regulation of cell migration,GO:0031532~actin cytoskeleton reorganization,GO:0034329~cell junction assembly,GO:0034394~protein localization to cell surface,GO:0042177~negative regulation of protein catabolic process,GO:0042384~cilium assembly,GO:0042789~mRNA transcription from RNA polymerase II promoter,GO:0042993~positive regulation of transcription factor import into nucleus,GO:0043066~negative regulation of apoptotic process,GO:0043113~receptor clustering,GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling,GO:0043433~negative regulation of sequence-specific DNA binding transcription factor activity,GO:0044319~wound healing, spreading of cells,GO:0045184~establishment of protein localization,GO:0050821~protein stabilization,GO:0051220~cytoplasmic sequestering of protein,GO:0051764~actin crosslink formation,GO:0060271~cilium morphogenesis,GO:0070527~platelet aggregation,GO:0071526~semaphorin-plexin signaling pathway,GO:0072659~protein localization to plasma membrane,GO:0090307~mitotic spindle assembly,GO:1900026~positive regulation of substrate adhesion-dependent cell spreading,GO:1901381~positive regulation of potassium ion transmembrane transport,GO:1905000~regulation of membrane repolarization during atrial cardiac muscle cell action potential,GO:1905031~regulation of membrane repolarization during cardiac muscle cell action potential,GO:2001046~positive regulation of integrin-mediated signaling pathway, GO:0005576~extracellular region,GO:0005634~nucleus,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005884~actin filament,GO:0005886~plasma membrane,GO:0005911~cell-cell junction,GO:0005913~cell-cell adherens junction,GO:0005925~focal adhesion,GO:0015629~actin cytoskeleton,GO:0016020~membrane,GO:0030018~Z disc,GO:0030863~cortical cytoskeleton,GO:0031012~extracellular matrix,GO:0031523~Myb complex,GO:0031941~filamentous actin,GO:0043025~neuronal cell body,GO:0043198~dendritic shaft,GO:0048471~perinuclear region of cytoplasm,GO:0070062~extracellular exosome,GO:0097440~apical dendrite, GO:0001664~G-protein coupled receptor binding,GO:0001948~glycoprotein binding,GO:0004871~signal transducer activity,GO:0005515~protein binding,GO:0008134~transcription factor binding,GO:0015459~potassium channel regulator activity,GO:0017048~Rho GTPase binding,GO:0017160~Ral GTPase binding,GO:0019900~kinase binding,GO:0031267~small GTPase binding,GO:0031852~mu-type opioid receptor binding,GO:0034988~Fc-gamma receptor I complex binding,GO:0042803~protein homodimerization activity,GO:0044325~ion channel binding,GO:0044822~poly(A) RNA binding,GO:0046332~SMAD binding,GO:0048365~Rac GTPase binding,GO:0051015~actin filament binding,GO:0051020~GTPase binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR001298:Filamin/ABP280 repeat,IPR001589:Actinin-type, actin-binding, conserved site,IPR001715:Calponin homology domain,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR017868:Filamin/ABP280 repeat-like, hsa04010:MAPK signaling pathway,hsa04510:Focal adhesion,hsa05132:Salmonella infection,hsa05205:Proteoglycans in cancer, 300048~Congenital short bowel syndrome,300048~Intestinal pseudoobstruction, neuronal,300049~Heterotopia, periventricular,300244~Terminal osseous dysplasia,300321~FG syndrome 2,300537~Heterotopia, periventricular, ED variant,304120~Otopalatodigital syndrome, type II,305620~Frontometaphyseal dysplasia,309350~Melnick-Needles syndrome,311300~Otopalatodigital syndrome, type I,314400~Cardiac valvular dysplasia, X-linked, SM00033:CH,SM00557:IG_FLMN, 3D-structure,Acetylation,Actin-binding,Alternative splicing,Cilium biogenesis/degradation,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Disease mutation,Isopeptide bond,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Ubl conjugation, chain:Filamin-A,domain:Actin-binding,domain:CH 1,domain:CH 2,helix,modified residue,region of interest:Hinge 1,region of interest:Hinge 2,region of interest:Interaction with furin,region of interest:Self-association site, tail,repeat:Filamin 1,repeat:Filamin 10,repeat:Filamin 11,repeat:Filamin 12,repeat:Filamin 13,repeat:Filamin 14,repeat:Filamin 15,repeat:Filamin 16,repeat:Filamin 17,repeat:Filamin 18,repeat:Filamin 19,repeat:Filamin 2,repeat:Filamin 20,repeat:Filamin 21,repeat:Filamin 22,repeat:Filamin 23,repeat:Filamin 24,repeat:Filamin 3,repeat:Filamin 4,repeat:Filamin 5,repeat:Filamin 6,repeat:Filamin 7,repeat:Filamin 8,repeat:Filamin 9,sequence conflict,sequence variant,site:Cleavage; by calpain,splice variant,strand, Q14315 filamin C(FLNC) Homo sapiens GO:0034329~cell junction assembly,GO:0048747~muscle fiber development, GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005856~cytoskeleton,GO:0005886~plasma membrane,GO:0005925~focal adhesion,GO:0016528~sarcoplasm,GO:0030018~Z disc,GO:0042383~sarcolemma,GO:0043034~costamere, GO:0005515~protein binding,GO:0008092~cytoskeletal protein binding,GO:0030506~ankyrin binding,GO:0051015~actin filament binding, IPR001298:Filamin/ABP280 repeat,IPR001589:Actinin-type, actin-binding, conserved site,IPR001715:Calponin homology domain,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR017868:Filamin/ABP280 repeat-like, hsa04010:MAPK signaling pathway,hsa04510:Focal adhesion,hsa05132:Salmonella infection,hsa05205:Proteoglycans in cancer, 609524~Myopathy, myofibrillar, 5,614065~Myopathy, distal, 4, SM00033:CH,SM00557:IG_FLMN, 3D-structure,Actin-binding,Alternative splicing,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Disease mutation,Membrane,Methylation,Myofibrillar myopathy,Phosphoprotein,Polymorphism,Reference proteome,Repeat,Ubl conjugation, chain:Filamin-C,domain:Actin-binding,domain:CH 1,domain:CH 2,helix,modified residue,mutagenesis site,region of interest:Hinge 1,region of interest:Hinge 2,region of interest:Interaction with INPPL1,region of interest:Intradomain insert,region of interest:Self-association site, tail,repeat:Filamin 1,repeat:Filamin 10,repeat:Filamin 11,repeat:Filamin 12,repeat:Filamin 13,repeat:Filamin 14,repeat:Filamin 15,repeat:Filamin 16,repeat:Filamin 17,repeat:Filamin 18,repeat:Filamin 19,repeat:Filamin 2,repeat:Filamin 20,repeat:Filamin 21,repeat:Filamin 22,repeat:Filamin 23,repeat:Filamin 24,repeat:Filamin 3,repeat:Filamin 4,repeat:Filamin 5,repeat:Filamin 6,repeat:Filamin 7,repeat:Filamin 8,repeat:Filamin 9,sequence conflict,sequence variant,splice variant,strand,turn, Q5VW36 focadhesin(FOCAD) Homo sapiens GO:0005925~focal adhesion,GO:0016021~integral component of membrane, GO:0005515~protein binding, IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold,IPR021392:Protein of unknown function DUF3028,IPR022542:Domain of unknown function DUF3730, Acetylation,Cell junction,Complete proteome,Membrane,Polymorphism,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix, chain:Uncharacterized protein KIAA1797,modified residue,sequence conflict,sequence variant,transmembrane region, O77564 folate hydrolase 1B(FOLH1B) Sus scrofa GO:0006508~proteolysis,GO:0006760~folic acid-containing compound metabolic process,GO:0035609~C-terminal protein deglutamylation, GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0009986~cell surface,GO:0016021~integral component of membrane,GO:0070062~extracellular exosome, GO:0004180~carboxypeptidase activity,GO:0004181~metallocarboxypeptidase activity,GO:0008237~metallopeptidase activity,GO:0016805~dipeptidase activity,GO:0046872~metal ion binding,GO:1904492~Ac-Asp-Glu binding,GO:1904493~tetrahydrofolyl-poly(glutamate) polymer binding, IPR003137:Protease-associated domain, PA,IPR007365:Transferrin receptor-like, dimerisation domain,IPR007484:Peptidase M28, ssc00250:Alanine, aspartate and glutamate metabolism,ssc01100:Metabolic pathways,ssc04977:Vitamin digestion and absorption, Calcium,Carboxypeptidase,Cell membrane,Complete proteome,Dipeptidase,Direct protein sequencing,Glycoprotein,Hydrolase,Membrane,Metal-binding,Metalloprotease,Multifunctional enzyme,Phosphoprotein,Protease,Proteomics identification,Reference proteome,Signal-anchor,Transmembrane,Transmembrane helix,Zinc, active site:Charge relay system,active site:Nucleophile; for NAALADase activity,binding site:Substrate,chain:Glutamate carboxypeptidase 2,compositionally biased region:Poly-Pro,glycosylation site:N-linked (GlcNAc...),metal ion-binding site:Calcium,metal ion-binding site:Calcium; via carbonyl oxygen,metal ion-binding site:Zinc 1,metal ion-binding site:Zinc 2,region of interest:NAALADase,region of interest:Substrate binding,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q6ZPF4 formin-like 3(Fmnl3) Mus musculus GO:0001525~angiogenesis,GO:0007010~cytoskeleton organization,GO:0007275~multicellular organism development,GO:0008360~regulation of cell shape,GO:0016043~cellular component organization,GO:0016477~cell migration,GO:0030036~actin cytoskeleton organization, GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0016020~membrane, GO:0003779~actin binding,GO:0005515~protein binding,GO:0017048~Rho GTPase binding,GO:0032794~GTPase activating protein binding, IPR010472:Diaphanous FH3,IPR010473:Diaphanous GTPase-binding,IPR014768:GTPase-binding/formin homology 3,IPR015425:Actin-binding FH2,IPR016024:Armadillo-type fold, SM00498:FH2,SM01139:SM01139,SM01140:SM01140, 3D-structure,Alternative splicing,Angiogenesis,Cell membrane,Coiled coil,Complete proteome,Cytoplasm,Developmental protein,Lipoprotein,Membrane,Myristate,Phosphoprotein,Proteomics identification,Reference proteome, chain:Formin-like protein 3,compositionally biased region:Pro-rich,domain:FH2,domain:GBD/FH3,modified residue,splice variant, Q9BTY2 fucosidase, alpha-L- 2, plasma(FUCA2) Homo sapiens GO:0005975~carbohydrate metabolic process,GO:0006004~fucose metabolic process,GO:0009617~response to bacterium,GO:0016139~glycoside catabolic process,GO:2000535~regulation of entry of bacterium into host cell, GO:0005615~extracellular space,GO:0070062~extracellular exosome, GO:0004560~alpha-L-fucosidase activity,GO:0005515~protein binding, IPR000933:Glycoside hydrolase, family 29,IPR013780:Glycosyl hydrolase, family 13, all-beta,IPR013781:Glycoside hydrolase, catalytic domain,IPR016286:Glycoside hydrolase, family 29, bacteria/metazoa/fungi,IPR017853:Glycoside hydrolase, superfamily,IPR018526:Glycoside hydrolase, family 29, conserved site, hsa00511:Other glycan degradation, PIRSF001092:alpha-L-fucosidase, SM00812:Alpha_L_fucos, Alternative splicing,Complete proteome,Glycoprotein,Glycosidase,Hydrolase,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Secreted,Signal, chain:Plasma alpha-L-fucosidase,glycosylation site:N-linked (GlcNAc...),sequence conflict,sequence variant,signal peptide,site:May be important for catalysis, Q10980 fucosyltransferase 1(Fut1) Rattus norvegicus GO:0005975~carbohydrate metabolic process,GO:0006486~protein glycosylation,GO:0036065~fucosylation, GO:0016021~integral component of membrane,GO:0032580~Golgi cisterna membrane, GO:0008107~galactoside 2-alpha-L-fucosyltransferase activity, IPR002516:Glycosyl transferase, family 11, rno00601:Glycosphingolipid biosynthesis - lacto and neolacto series,rno00603:Glycosphingolipid biosynthesis - globo series,rno01100:Metabolic pathways, Complete proteome,Glycoprotein,Glycosyltransferase,Golgi apparatus,Membrane,Reference proteome,Signal-anchor,Transferase,Transmembrane,Transmembrane helix, chain:Galactoside 2-alpha-L-fucosyltransferase 1,glycosylation site:N-linked (GlcNAc...),topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, Q6NVP8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)(fut8) Xenopus tropicalis GO:0006487~protein N-linked glycosylation,GO:0018279~protein N-linked glycosylation via asparagine,GO:0033578~protein glycosylation in Golgi,GO:0036071~N-glycan fucosylation,GO:0046368~GDP-L-fucose metabolic process, GO:0016021~integral component of membrane,GO:0032580~Golgi cisterna membrane, GO:0008424~glycoprotein 6-alpha-L-fucosyltransferase activity,GO:0046921~alpha-(1->6)-fucosyltransferase activity, IPR001452:Src homology-3 domain,IPR015827:Alpha-(1,6)-fucosyltransferase, eukaryotic type,IPR027350:Glycosyltransferase family 23 (GT23) domain, xtr00510:N-Glycan biosynthesis,xtr00533:Glycosaminoglycan biosynthesis - keratan sulfate,xtr01100:Metabolic pathways, PIRSF000472:alpha-(1,6)-fucosyltransferase, eukaryotic type, SM00326:SH3, Complete proteome,Disulfide bond,Glycosyltransferase,Golgi apparatus,Membrane,Reference proteome,SH3 domain,SH3-binding,Signal-anchor,Transferase,Transmembrane,Transmembrane helix, chain:Alpha-(1,6)-fucosyltransferase,domain:SH3,region of interest:Important for donor substrate binding,short sequence motif:SH3-binding,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, A5PKH3 fumarylacetoacetate hydrolase(FAH) Bos taurus GO:0006527~arginine catabolic process,GO:0006559~L-phenylalanine catabolic process,GO:0006572~tyrosine catabolic process,GO:0009072~aromatic amino acid family metabolic process, GO:0070062~extracellular exosome, GO:0004334~fumarylacetoacetase activity,GO:0046872~metal ion binding, IPR005959:Fumarylacetoacetase,IPR011234:Fumarylacetoacetase, C-terminal-related,IPR015377:Fumarylacetoacetase, N-terminal, bta00350:Tyrosine metabolism,bta01100:Metabolic pathways, Acetylation,Calcium,Complete proteome,Hydrolase,Magnesium,Metal-binding,Phenylalanine catabolism,Phosphoprotein,Proteomics identification,Reference proteome,Tyrosine catabolism, active site:Proton acceptor,binding site:Substrate,chain:Fumarylacetoacetase,metal ion-binding site:Calcium,metal ion-binding site:Magnesium,modified residue,sequence conflict, Q99999 galactose-3-O-sulfotransferase 1(GAL3ST1) Homo sapiens GO:0006487~protein N-linked glycosylation,GO:0006682~galactosylceramide biosynthetic process,GO:0007283~spermatogenesis,GO:0009247~glycolipid biosynthetic process,GO:0042552~myelination, GO:0000139~Golgi membrane,GO:0005794~Golgi apparatus,GO:0005887~integral component of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0001733~galactosylceramide sulfotransferase activity,GO:0008146~sulfotransferase activity, IPR009729:Galactose-3-O-sulfotransferase,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa00565:Ether lipid metabolism,hsa00600:Sphingolipid metabolism,hsa01100:Metabolic pathways, Complete proteome,Direct protein sequencing,Glycoprotein,Golgi apparatus,Lipid metabolism,Membrane,Polymorphism,Reference proteome,Signal-anchor,Sphingolipid metabolism,Transferase,Transmembrane,Transmembrane helix, chain:Galactosylceramide sulfotransferase,glycosylation site:N-linked (GlcNAc...),sequence conflict,sequence variant,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, P38552 galectin 4(Lgals4) Rattus norvegicus GO:0005615~extracellular space, GO:0016936~galactoside binding,GO:0030246~carbohydrate binding, IPR001079:Galectin, carbohydrate recognition domain,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR015533:Galectin-4/6, SM00276:GLECT,SM00908:SM00908, Complete proteome,Direct protein sequencing,Lectin,Phosphoprotein,Reference proteome,Repeat, chain:Galectin-4,domain:Galectin 1,domain:Galectin 2,region of interest:Beta-galactoside binding, Q9Z0L8 gamma-glutamyl hydrolase(Ggh) Mus musculus GO:0006541~glutamine metabolic process,GO:0010043~response to zinc ion,GO:0032868~response to insulin,GO:0042493~response to drug,GO:0045471~response to ethanol,GO:0046900~tetrahydrofolylpolyglutamate metabolic process, GO:0005576~extracellular region,GO:0005615~extracellular space,GO:0005634~nucleus,GO:0005764~lysosome,GO:0005829~cytosol,GO:0042470~melanosome,GO:0070062~extracellular exosome, GO:0003824~catalytic activity,GO:0008233~peptidase activity,GO:0008242~omega peptidase activity,GO:0016787~hydrolase activity,GO:0034722~gamma-glutamyl-peptidase activity, IPR011697:Peptidase C26,IPR015527:Peptidase C26, gamma-glutamyl hydrolase, mmu00790:Folate biosynthesis, Alternative splicing,Complete proteome,Glycoprotein,Hydrolase,Lysosome,Reference proteome,Secreted,Signal, active site:Nucleophile,active site:Proton donor,chain:Gamma-glutamyl hydrolase,domain:Gamma-glutamyl hydrolase,glycosylation site:N-linked (GlcNAc...),glycosylation site:N-linked (GlcNAc...) (high mannose),signal peptide,splice variant, Q12789 general transcription factor IIIC subunit 1(GTF3C1) Homo sapiens h_RNApol3Pathway:RNA polymerase III transcription, GO:0006351~transcription, DNA-templated,GO:0006383~transcription from RNA polymerase III promoter,GO:0009303~rRNA transcription,GO:0009304~tRNA transcription,GO:0042791~5S class rRNA transcription from RNA polymerase III type 1 promoter,GO:0042797~tRNA transcription from RNA polymerase III promoter, GO:0000127~transcription factor TFIIIC complex,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0016020~membrane,GO:0030529~intracellular ribonucleoprotein complex, GO:0003677~DNA binding,GO:0005515~protein binding, IPR007309:B-block binding subunit of TFIIIC, Alternative splicing,Complete proteome,Direct protein sequencing,DNA-binding,Isopeptide bond,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transcription,Ubl conjugation, chain:General transcription factor 3C polypeptide 1,compositionally biased region:Arg/Lys-rich (basic),compositionally biased region:Asp/Glu-rich (acidic),modified residue,sequence conflict,sequence variant,splice variant, Q3U3C9 genetic suppressor element 1, coiled-coil protein(Gse1) Mus musculus IPR022207:Genetic suppressor element-like, Acetylation,Alternative splicing,Coiled coil,Complete proteome,Methylation,Phosphoprotein,Reference proteome, chain:Genetic suppressor element 1,compositionally biased region:Poly-Arg,compositionally biased region:Pro-rich,modified residue,sequence conflict,splice variant, P56966 geranylgeranyl diphosphate synthase 1(GGPS1) Bos taurus GO:0006720~isoprenoid metabolic process,GO:0033384~geranyl diphosphate biosynthetic process,GO:0033386~geranylgeranyl diphosphate biosynthetic process,GO:0045337~farnesyl diphosphate biosynthetic process, GO:0005737~cytoplasm, GO:0004161~dimethylallyltranstransferase activity,GO:0004311~farnesyltranstransferase activity,GO:0004337~geranyltranstransferase activity,GO:0046872~metal ion binding, IPR000092:Polyprenyl synthetase,IPR008949:Terpenoid synthase, bta00900:Terpenoid backbone biosynthesis,bta01100:Metabolic pathways,bta01130:Biosynthesis of antibiotics, Acetylation,Complete proteome,Cytoplasm,Direct protein sequencing,Isoprene biosynthesis,Magnesium,Metal-binding,Reference proteome,Transferase, binding site:Dimethylallyl diphosphate,binding site:Isopentenyl diphosphate,chain:Geranylgeranyl pyrophosphate synthetase,metal ion-binding site:Magnesium 1,metal ion-binding site:Magnesium 2,metal ion-binding site:Magnesium 3,modified residue, O95749 geranylgeranyl diphosphate synthase 1(GGPS1) Homo sapiens GO:0006695~cholesterol biosynthetic process,GO:0006720~isoprenoid metabolic process,GO:0008299~isoprenoid biosynthetic process,GO:0033384~geranyl diphosphate biosynthetic process,GO:0033386~geranylgeranyl diphosphate biosynthetic process,GO:0045337~farnesyl diphosphate biosynthetic process, GO:0005829~cytosol, GO:0004161~dimethylallyltranstransferase activity,GO:0004311~farnesyltranstransferase activity,GO:0004337~geranyltranstransferase activity,GO:0005515~protein binding,GO:0042802~identical protein binding,GO:0046872~metal ion binding, IPR000092:Polyprenyl synthetase,IPR008949:Terpenoid synthase, hsa00900:Terpenoid backbone biosynthesis,hsa01100:Metabolic pathways,hsa01130:Biosynthesis of antibiotics, 3D-structure,Acetylation,Alternative splicing,Complete proteome,Cytoplasm,Isoprene biosynthesis,Magnesium,Metal-binding,Proteomics identification,Reference proteome,Transferase, binding site:Dimethylallyl diphosphate,binding site:Isopentenyl diphosphate,chain:Geranylgeranyl pyrophosphate synthetase,helix,metal ion-binding site:Magnesium 1,metal ion-binding site:Magnesium 2,metal ion-binding site:Magnesium 3,modified residue,sequence conflict,strand, Q3UHD2 glucose-fructose oxidoreductase domain containing 1(Gfod1) Mus musculus General function prediction only, GO:0055114~oxidation-reduction process, GO:0005576~extracellular region, GO:0016491~oxidoreductase activity, IPR000683:Oxidoreductase, N-terminal,IPR016040:NAD(P)-binding domain, Complete proteome,Oxidoreductase,Reference proteome,Secreted,Signal, chain:Glucose-fructose oxidoreductase domain- containing protein 1,signal peptide, O18835 glucuronidase beta(GUSB) Canis lupus familiaris GO:0005975~carbohydrate metabolic process, GO:0005615~extracellular space,GO:0005764~lysosome,GO:0016020~membrane,GO:0043231~intracellular membrane-bounded organelle,GO:0070062~extracellular exosome, GO:0004553~hydrolase activity, hydrolyzing O-glycosyl compounds,GO:0004566~beta-glucuronidase activity, IPR006101:Glycoside hydrolase, family 2,IPR006102:Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich,IPR006103:Glycoside hydrolase, family 2, TIM barrel,IPR006104:Glycoside hydrolase, family 2, N-terminal,IPR008979:Galactose-binding domain-like,IPR013781:Glycoside hydrolase, catalytic domain,IPR013812:Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain,IPR017853:Glycoside hydrolase, superfamily,IPR023230:Glycoside hydrolase, family 2, conserved site,IPR023232:Glycoside hydrolase, family 2, active site, cfa00040:Pentose and glucuronate interconversions,cfa00531:Glycosaminoglycan degradation,cfa00860:Porphyrin and chlorophyll metabolism,cfa00983:Drug metabolism - other enzymes,cfa01100:Metabolic pathways,cfa04142:Lysosome, Complete proteome,Disease mutation,Glycoprotein,Glycosidase,Hydrolase,Lysosome,Reference proteome,Signal, active site:Proton donor,chain:Beta-glucuronidase,glycosylation site:N-linked (GlcNAc...),sequence variant,signal peptide, Q12680 glutamate synthase (NADH)(GLT1) Saccharomyces cerevisiae S288C GO:0006537~glutamate biosynthetic process,GO:0006541~glutamine metabolic process,GO:0006807~nitrogen compound metabolic process,GO:0008152~metabolic process,GO:0008652~cellular amino acid biosynthetic process,GO:0019676~ammonia assimilation cycle,GO:0055114~oxidation-reduction process,GO:0097054~L-glutamate biosynthetic process, GO:0005739~mitochondrion, GO:0003824~catalytic activity,GO:0005506~iron ion binding,GO:0010181~FMN binding,GO:0015930~glutamate synthase activity,GO:0016040~glutamate synthase (NADH) activity,GO:0016491~oxidoreductase activity,GO:0016638~oxidoreductase activity, acting on the CH-NH2 group of donors,GO:0016639~oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor,GO:0045181~glutamate synthase activity, NAD(P)H as acceptor,GO:0046872~metal ion binding,GO:0050660~flavin adenine dinucleotide binding,GO:0051536~iron-sulfur cluster binding,GO:0051538~3 iron, 4 sulfur cluster binding, IPR002489:Glutamate synthase, alpha subunit, C-terminal,IPR002932:Glutamate synthase, central-C,IPR006005:Glutamate synthase, NADH/NADPH, small subunit 1,IPR006982:Glutamate synthase, central-N,IPR009051:Alpha-helical ferredoxin,IPR012220:Glutamate synthase, eukaryotic,IPR013785:Aldolase-type TIM barrel,IPR016040:NAD(P)-binding domain,IPR017932:Glutamine amidotransferase type 2 domain,IPR023753:Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain, sce00250:Alanine, aspartate and glutamate metabolism,sce00910:Nitrogen metabolism,sce01100:Metabolic pathways,sce01110:Biosynthesis of secondary metabolites,sce01130:Biosynthesis of antibiotics,sce01230:Biosynthesis of amino acids, PIRSF000187:glutamate synthase (NADH), eukaryotic type, 3Fe-4S,Amino-acid biosynthesis,Coiled coil,Complete proteome,Direct protein sequencing,FAD,Flavoprotein,FMN,Glutamate biosynthesis,Glutamine amidotransferase,Iron,Iron-sulfur,Metal-binding,NAD,Oxidoreductase,Phosphoprotein,Reference proteome,Zymogen, active site:For GATase activity,chain:Glutamate synthase [NADH],domain:Glutamine amidotransferase type-2,metal ion-binding site:Iron-sulfur (3Fe-4S),nucleotide phosphate-binding region:FMN,nucleotide phosphate-binding region:NAD,sequence conflict, A6QLU1 glycerol-3-phosphate dehydrogenase 2(GPD2) Bos taurus Energy production and conversion, GO:0006072~glycerol-3-phosphate metabolic process,GO:0006094~gluconeogenesis,GO:0019563~glycerol catabolic process,GO:0035264~multicellular organism growth,GO:0043010~camera-type eye development,GO:0055114~oxidation-reduction process, GO:0005743~mitochondrial inner membrane,GO:0009331~glycerol-3-phosphate dehydrogenase complex, GO:0005509~calcium ion binding,GO:0052591~sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity, IPR000447:FAD-dependent glycerol-3-phosphate dehydrogenase,IPR002048:EF-hand domain,IPR006076:FAD dependent oxidoreductase,IPR011992:EF-hand-like domain,IPR018247:EF-Hand 1, calcium-binding site,IPR023753:Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain, bta00564:Glycerophospholipid metabolism, SM00054:EFh, Calcium,Complete proteome,FAD,Flavoprotein,Metal-binding,Mitochondrion,Oxidoreductase,Phosphoprotein,Reference proteome,Repeat,Transit peptide, chain:Glycerol-3-phosphate dehydrogenase, mitochondrial,domain:EF-hand 1,domain:EF-hand 2,modified residue,nucleotide phosphate-binding region:FAD,transit peptide:Mitochondrion, Q9NPB8 glycerophosphocholine phosphodiesterase 1(GPCPD1) Homo sapiens GO:0006629~lipid metabolic process,GO:0007519~skeletal muscle tissue development,GO:0030643~cellular phosphate ion homeostasis,GO:0046475~glycerophospholipid catabolic process, GO:0005829~cytosol, GO:0008081~phosphoric diester hydrolase activity,GO:0008889~glycerophosphodiester phosphodiesterase activity,GO:0047389~glycerophosphocholine phosphodiesterase activity,GO:2001070~starch binding, IPR002044:Carbohydrate binding module family 20,IPR013783:Immunoglobulin-like fold,IPR013784:Carbohydrate-binding-like fold,IPR017946:PLC-like phosphodiesterase, TIM beta/alpha-barrel domain, hsa00564:Glycerophospholipid metabolism,hsa05231:Choline metabolism in cancer, SM01065:SM01065, 3D-structure,Complete proteome,Cytoplasm,Hydrolase,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, binding site:Substrate,chain:Putative glycerophosphodiester phosphodiesterase 5,compositionally biased region:Poly-Asp,domain:CBM20,domain:GDPD,helix,modified residue,region of interest:Substrate binding,sequence variant,strand,turn, Q9CZD3 glycyl-tRNA synthetase(Gars) Mus musculus Translation, ribosomal structure and biogenesis, GO:0006412~translation,GO:0006418~tRNA aminoacylation for protein translation,GO:0006426~glycyl-tRNA aminoacylation,GO:0015966~diadenosine tetraphosphate biosynthetic process, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0030141~secretory granule,GO:0030424~axon,GO:0042995~cell projection,GO:0070062~extracellular exosome, GO:0000166~nucleotide binding,GO:0004081~bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity,GO:0004812~aminoacyl-tRNA ligase activity,GO:0004820~glycine-tRNA ligase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016787~hydrolase activity,GO:0016874~ligase activity,GO:0046983~protein dimerization activity, IPR000738:WHEP-TRS,IPR002314:Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain,IPR002315:Glycyl-tRNA synthetase, alpha2 dimer,IPR004154:Anticodon-binding,IPR006195:Aminoacyl-tRNA synthetase, class II,IPR009068:S15/NS1, RNA-binding,IPR027031:Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2, mmu00970:Aminoacyl-tRNA biosynthesis, SM00991:SM00991, Acetylation,Aminoacyl-tRNA synthetase,ATP-binding,Cell projection,Complete proteome,Cytoplasm,Direct protein sequencing,Hydrolase,Ligase,Mitochondrion,Nucleotide-binding,Phosphoprotein,Protein biosynthesis,Reference proteome, binding site:Substrate,binding site:Substrate; via carbonyl oxygen,chain:Glycyl-tRNA synthetase,domain:WHEP-TRS,modified residue,nucleotide phosphate-binding region:ATP,region of interest:Substrate binding,sequence conflict, Q9UBQ7 glyoxylate and hydroxypyruvate reductase(GRHPR) Homo sapiens Energy production and conversion / Coenzyme metabolism / General function prediction only, GO:0007588~excretion,GO:0008152~metabolic process,GO:0043648~dicarboxylic acid metabolic process,GO:0046487~glyoxylate metabolic process,GO:0051259~protein oligomerization,GO:0055114~oxidation-reduction process, GO:0005737~cytoplasm,GO:0005782~peroxisomal matrix,GO:0005829~cytosol,GO:0070062~extracellular exosome, GO:0008465~glycerate dehydrogenase activity,GO:0016616~oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor,GO:0016618~hydroxypyruvate reductase activity,GO:0030267~glyoxylate reductase (NADP) activity,GO:0031406~carboxylic acid binding,GO:0042803~protein homodimerization activity,GO:0051287~NAD binding,GO:0070402~NADPH binding, IPR006139:D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain,IPR006140:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding,IPR016040:NAD(P)-binding domain, hsa00260:Glycine, serine and threonine metabolism,hsa00620:Pyruvate metabolism,hsa00630:Glyoxylate and dicarboxylate metabolism,hsa01100:Metabolic pathways, 260000~Hyperoxaluria, primary, type II, 3D-structure,Alternative splicing,Complete proteome,NADP,Oxidoreductase,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, active site:Proton donor,binding site:NADP,binding site:NADP; via amide nitrogen,binding site:NADP; via carbonyl oxygen,binding site:Substrate,chain:Glyoxylate reductase/hydroxypyruvate reductase,helix,nucleotide phosphate-binding region:NADP,region of interest:Substrate binding,sequence variant,site:Raises pKa of active site His,strand,turn, P28799 granulin precursor(GRN) Homo sapiens h_pepiPathway:Proepithelin Conversion to Epithelin and Wound Repair Control, GO:0007165~signal transduction, GO:0005615~extracellular space,GO:0043231~intracellular membrane-bounded organelle,GO:0070062~extracellular exosome, GO:0005125~cytokine activity,GO:0005515~protein binding,GO:0008083~growth factor activity,GO:0044822~poly(A) RNA binding, IPR000118:Granulin, 607485~Aphasia, primary progressive,607485~Frontotemporal lobar degeneration with ubiquitin-positive inclusions,614706~Ceroid lipofuscinosis, neuronal, 11, SM00277:GRAN, 3D-structure,Alternative splicing,Complete proteome,Cytokine,Direct protein sequencing,Disulfide bond,Glycoprotein,Neurodegeneration,Neuronal ceroid lipofuscinosis,Polymorphism,Proteomics identification,Reference proteome,Repeat,Secreted,Signal, chain:Acrogranin,disulfide bond,glycosylation site:N-linked (GlcNAc...),peptide:Granulin-1,peptide:Granulin-2,peptide:Granulin-3,peptide:Granulin-4,peptide:Granulin-5,peptide:Granulin-6,peptide:Granulin-7,peptide:Paragranulin,sequence conflict,sequence variant,signal peptide,splice variant,strand,turn, O75343 guanylate cyclase 1 soluble subunit beta 2 (pseudogene)(GUCY1B2) Homo sapiens h_raccPathway:Ion Channels and Their Functional Role in Vascular Endothelium, GO:0006182~cGMP biosynthetic process,GO:0007165~signal transduction,GO:0035556~intracellular signal transduction, GO:0005886~plasma membrane,GO:0008074~guanylate cyclase complex, soluble, GO:0004383~guanylate cyclase activity,GO:0005525~GTP binding,GO:0020037~heme binding,GO:0046872~metal ion binding, IPR001054:Adenylyl cyclase class-3/4/guanylyl cyclase,IPR011644:Heme-NO binding,IPR011645:Haem NO binding associated,IPR018297:Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site,IPR024096:NO signalling/Golgi transport ligand-binding domain, SM00044:CYCc, cGMP biosynthesis,Complete proteome,Cytoplasm,GTP-binding,Heme,Iron,Lyase,Metal-binding,Nucleotide-binding,Polymorphism,Reference proteome, Q6AZB8 harbinger transposase derived 1(harbi1) Danio rerio GO:0005634~nucleus,GO:0005737~cytoplasm, GO:0004518~nuclease activity,GO:0016787~hydrolase activity,GO:0042578~phosphoric ester hydrolase activity,GO:0043765~T/G mismatch-specific endonuclease activity,GO:0044824~retroviral 3' processing activity,GO:0046872~metal ion binding, IPR026103:Harbinger transposase-derived nuclease, Complete proteome,Cytoplasm,Hydrolase,Metal-binding,Nuclease,Nucleus,Reference proteome, chain:Putative nuclease HARBI1,metal ion-binding site:Divalent metal cation,sequence conflict, E9Q7X6 heart development protein with EGF-like domains 1(Heg1) Mus musculus GO:0001570~vasculogenesis,GO:0001701~in utero embryonic development,GO:0001885~endothelial cell development,GO:0001886~endothelial cell morphogenesis,GO:0001944~vasculature development,GO:0001945~lymph vessel development,GO:0003017~lymph circulation,GO:0003209~cardiac atrium morphogenesis,GO:0003222~ventricular trabecula myocardium morphogenesis,GO:0003281~ventricular septum development,GO:0007043~cell-cell junction assembly,GO:0007275~multicellular organism development,GO:0007507~heart development,GO:0009791~post-embryonic development,GO:0030324~lung development,GO:0035264~multicellular organism growth,GO:0045216~cell-cell junction organization,GO:0048845~venous blood vessel morphogenesis,GO:0050878~regulation of body fluid levels,GO:0055017~cardiac muscle tissue growth,GO:0060039~pericardium development,GO:0090271~positive regulation of fibroblast growth factor production, GO:0005886~plasma membrane,GO:0005911~cell-cell junction,GO:0009897~external side of plasma membrane,GO:0009986~cell surface,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030054~cell junction, GO:0005509~calcium ion binding,GO:0005515~protein binding, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR001881:EGF-like calcium-binding,IPR013032:EGF-like, conserved site,IPR018097:EGF-like calcium-binding, conserved site, SM00179:EGF_CA,SM00181:EGF, Alternative splicing,Calcium,Cell junction,Cell membrane,Complete proteome,Developmental protein,Disulfide bond,EGF-like domain,Glycoprotein,Membrane,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, P14625 heat shock protein 90 beta family member 1(HSP90B1) Homo sapiens GO:0001666~response to hypoxia,GO:0002224~toll-like receptor signaling pathway,GO:0006457~protein folding,GO:0006898~receptor-mediated endocytosis,GO:0006950~response to stress,GO:0015031~protein transport,GO:0030433~ER-associated ubiquitin-dependent protein catabolic process,GO:0030970~retrograde protein transport, ER to cytosol,GO:0031247~actin rod assembly,GO:0034975~protein folding in endoplasmic reticulum,GO:0034976~response to endoplasmic reticulum stress,GO:0036500~ATF6-mediated unfolded protein response,GO:0043066~negative regulation of apoptotic process,GO:0043666~regulation of phosphoprotein phosphatase activity,GO:0051208~sequestering of calcium ion,GO:0071318~cellular response to ATP, GO:0005576~extracellular region,GO:0005634~nucleus,GO:0005783~endoplasmic reticulum,GO:0005788~endoplasmic reticulum lumen,GO:0005789~endoplasmic reticulum membrane,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005925~focal adhesion,GO:0016020~membrane,GO:0030496~midbody,GO:0031012~extracellular matrix,GO:0034663~endoplasmic reticulum chaperone complex,GO:0042470~melanosome,GO:0048471~perinuclear region of cytoplasm,GO:0070062~extracellular exosome,GO:0071682~endocytic vesicle lumen, GO:0003723~RNA binding,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0019903~protein phosphatase binding,GO:0046790~virion binding,GO:0050750~low-density lipoprotein particle receptor binding,GO:0051082~unfolded protein binding, IPR001404:Heat shock protein Hsp90,IPR003594:Histidine kinase-like ATPase, ATP-binding domain,IPR019805:Heat shock protein Hsp90, conserved site,IPR020568:Ribosomal protein S5 domain 2-type fold,IPR020575:Heat shock protein Hsp90, N-terminal, hsa04141:Protein processing in endoplasmic reticulum,hsa04151:PI3K-Akt signaling pathway,hsa04915:Estrogen signaling pathway,hsa04918:Thyroid hormone synthesis,hsa05200:Pathways in cancer,hsa05215:Prostate cancer, PIRSF002583:heat shock protein, HSP90/HTPG types, SM00387:HATPase_c, 3D-structure,Acetylation,ATP-binding,Calcium,Chaperone,Coiled coil,Complete proteome,Direct protein sequencing,Disulfide bond,Endoplasmic reticulum,Glycoprotein,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome,Signal,Stress response, binding site:ATP,binding site:ATP; via amide nitrogen,chain:Endoplasmin,disulfide bond,glycosylation site:N-linked (GlcNAc...),modified residue,sequence conflict,short sequence motif:Prevents secretion from ER,signal peptide, Q96MM6 heat shock protein family A (Hsp70) member 12B(HSPA12B) Homo sapiens Posttranslational modification, protein turnover, chaperones, GO:0005515~protein binding,GO:0005524~ATP binding, ATP-binding,Complete proteome,Nucleotide-binding,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Stress response, chain:Heat shock 70 kDa protein 12B,modified residue,sequence conflict,sequence variant, Q6NYU2 helicase with zinc finger(helz) Danio rerio GO:0006355~regulation of transcription, DNA-templated, GO:0005634~nucleus, GO:0000166~nucleotide binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0004386~helicase activity,GO:0005524~ATP binding,GO:0016787~hydrolase activity,GO:0046872~metal ion binding, IPR000571:Zinc finger, CCCH-type,IPR011539:Rel homology domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00356:ZnF_C3H1, ATP-binding,Complete proteome,Helicase,Hydrolase,Metal-binding,Nucleotide-binding,Nucleus,Proteomics identification,Reference proteome,Zinc,Zinc-finger, chain:Probable helicase with zinc finger domain,nucleotide phosphate-binding region:ATP,short sequence motif:DEAA box,zinc finger region:C3H1-type, Q9NRZ9 helicase, lymphoid-specific(HELLS) Homo sapiens Transcription / DNA replication, recombination, and repair, GO:0001655~urogenital system development,GO:0006306~DNA methylation,GO:0006346~methylation-dependent chromatin silencing,GO:0006351~transcription, DNA-templated,GO:0007067~mitotic nuclear division,GO:0007275~multicellular organism development,GO:0010216~maintenance of DNA methylation,GO:0031508~pericentric heterochromatin assembly,GO:0046651~lymphocyte proliferation,GO:0051301~cell division,GO:2001243~negative regulation of intrinsic apoptotic signaling pathway, GO:0000775~chromosome, centromeric region,GO:0005634~nucleus,GO:0005721~pericentric heterochromatin, GO:0003682~chromatin binding,GO:0004386~helicase activity,GO:0005515~protein binding,GO:0005524~ATP binding, IPR000330:SNF2-related,IPR001650:Helicase, C-terminal,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00487:DEXDc,SM00490:HELICc, Alternative splicing,ATP-binding,Cell cycle,Cell division,Coiled coil,Complete proteome,Developmental protein,Disease mutation,Helicase,Hydrolase,Mitosis,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transcription,Transcription regulation, chain:Lymphoid-specific helicase,domain:Helicase ATP-binding,domain:Helicase C-terminal,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,short sequence motif:DEAH box,splice variant, D3YXG0 hemicentin 1(Hmcn1) Mus musculus GO:0007049~cell cycle,GO:0051301~cell division, GO:0005576~extracellular region,GO:0005578~proteinaceous extracellular matrix,GO:0005604~basement membrane,GO:0005737~cytoplasm,GO:0005938~cell cortex,GO:0030054~cell junction,GO:0032154~cleavage furrow,GO:0070062~extracellular exosome, GO:0005509~calcium ion binding, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR000884:Thrombospondin, type 1 repeat,IPR001881:EGF-like calcium-binding,IPR002035:von Willebrand factor, type A,IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR006605:G2 nidogen/fibulin G2F,IPR007110:Immunoglobulin-like domain,IPR009017:Green fluorescent protein,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR013032:EGF-like, conserved site,IPR013098:Immunoglobulin I-set,IPR013106:Immunoglobulin V-set,IPR013783:Immunoglobulin-like fold,IPR018097:EGF-like calcium-binding, conserved site,IPR023413:Green fluorescent protein-like,IPR026823:Complement Clr-like EGF domain, SM00179:EGF_CA,SM00181:EGF,SM00209:TSP1,SM00406:IGv,SM00408:IGc2,SM00409:IG,SM00682:G2F, Alternative splicing,Basement membrane,Calcium,Cell cycle,Cell division,Cell junction,Complete proteome,Cytoplasm,Disulfide bond,EGF-like domain,Extracellular matrix,Glycoprotein,Reference proteome,Repeat,Secreted,Signal, B1H369 histone deacetylase 8(hdac8) Xenopus tropicalis Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005634~nucleus,GO:0005737~cytoplasm, GO:0004407~histone deacetylase activity,GO:0032041~NAD-dependent histone deacetylase activity (H3-K14 specific),GO:0046872~metal ion binding, IPR000286:Histone deacetylase superfamily,IPR003084:Histone deacetylase,IPR023801:Histone deacetylase domain, PIRSF037913:histone deacetylase class I, eukaryotic type, Chromatin regulator,Complete proteome,Cytoplasm,Hydrolase,Metal-binding,Nucleus,Reference proteome,Repressor,Transcription,Transcription regulation, active site:Proton acceptor,binding site:Substrate,binding site:Substrate; via carbonyl oxygen,chain:Histone deacetylase 8,metal ion-binding site:Divalent metal cation,region of interest:Histone deacetylase, C3XRY1 hypothetical protein(BRAFLDRAFT_123918) Branchiostoma floridae Function unknown, GO:0006338~chromatin remodeling,GO:0006351~transcription, DNA-templated,GO:0018193~peptidyl-amino acid modification,GO:0034720~histone H3-K4 demethylation,GO:0042254~ribosome biogenesis,GO:0043687~post-translational protein modification,GO:0045892~negative regulation of transcription, DNA-templated,GO:0070544~histone H3-K36 demethylation, GO:0005634~nucleus, GO:0005506~iron ion binding,GO:0016706~oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors,GO:0032453~histone demethylase activity (H3-K4 specific),GO:0051864~histone demethylase activity (H3-K36 specific), IPR003347:JmjC domain, Chromatin regulator,Complete proteome,Dioxygenase,Iron,Metal-binding,Nucleus,Oxidoreductase,Reference proteome,Repressor,Transcription,Transcription regulation, chain:Lysine-specific demethylase NO66,domain:JmjC,metal ion-binding site:Iron; catalytic, Q55FM5 hypothetical protein(DDB_G0268038) Dictyostelium discoideum AX4 GO:0005634~nucleus,GO:0005737~cytoplasm, IPR002110:Ankyrin repeat,IPR020683:Ankyrin repeat-containing domain, SM00248:ANK, ANK repeat,Complete proteome,Cytoplasm,Nucleus,Reference proteome,Repeat, A7RRJ0 hypothetical protein(NEMVEDRAFT_v1g201054) Nematostella vectensis GO:0006284~base-excision repair,GO:0043137~DNA replication, removal of RNA primer, GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0005739~mitochondrion, GO:0000287~magnesium ion binding,GO:0003677~DNA binding,GO:0008409~5'-3' exonuclease activity,GO:0017108~5'-flap endonuclease activity, IPR006084:XPG/Rad2 endonuclease,IPR006085:XPG N-terminal,IPR006086:XPG-I domain,IPR008918:Helix-hairpin-helix motif, class 2,IPR019974:XPG conserved site,IPR020045:5'-3' exonuclease, C-terminal domain,IPR023426:Flap structure-specific endonuclease, nve03030:DNA replication,nve03410:Base excision repair,nve03450:Non-homologous end-joining, SM00279:HhH2,SM00484:XPGI,SM00485:XPGN, Complete proteome,DNA damage,DNA repair,DNA replication,Endonuclease,Exonuclease,Hydrolase,Magnesium,Metal-binding,Mitochondrion,Nuclease,Nucleus,Phosphoprotein,Reference proteome, Q4PIN7 hypothetical protein(UMAG_00026) Ustilago maydis 521 GO:0000412~histone peptidyl-prolyl isomerization,GO:0061077~chaperone-mediated protein folding, GO:0005730~nucleolus,GO:0005789~endoplasmic reticulum membrane, GO:0003755~peptidyl-prolyl cis-trans isomerase activity,GO:0005528~FK506 binding, IPR001179:Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain,IPR023566:Peptidyl-prolyl cis-trans isomerase, FKBP-type,IPR026257:FK506-binding protein, PIRSF001473:peptidylprolyl isomerase FPR3, Chaperone,Complete proteome,Isomerase,Nucleus,Reference proteome,Rotamase, Q8T3B9 hypothetical protein(sem-2) Caenorhabditis elegans GO:0007501~mesodermal cell fate specification,GO:0040019~positive regulation of embryonic development,GO:0040026~positive regulation of vulval development,GO:0048337~positive regulation of mesodermal cell fate specification,GO:0048582~positive regulation of post-embryonic development,GO:0048626~myoblast fate specification,GO:1901046~positive regulation of oviposition, GO:0005634~nucleus, GO:0003677~DNA binding, IPR009071:High mobility group (HMG) box domain, SM00398:HMG, Complete proteome,Developmental protein,DNA-binding,Nucleus,Reference proteome,Transcription, Q9UI26 importin 11(IPO11) Homo sapiens Cell division and chromosome partitioning, GO:0006610~ribosomal protein import into nucleus,GO:0006886~intracellular protein transport,GO:0042991~transcription factor import into nucleus, GO:0005622~intracellular,GO:0005635~nuclear envelope,GO:0005829~cytosol, GO:0005515~protein binding,GO:0008536~Ran GTPase binding,GO:0008565~protein transporter activity, IPR001494:Importin-beta, N-terminal,IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold, SM00913:SM00913, Acetylation,Alternative splicing,Complete proteome,Cytoplasm,Nucleus,Phosphoprotein,Polymorphism,Protein transport,Proteomics identification,Reference proteome,Repeat,Signal,Transport, chain:Importin-11,domain:Importin N-terminal,modified residue,repeat:HEAT 1,repeat:HEAT 10,repeat:HEAT 11,repeat:HEAT 12,repeat:HEAT 13,repeat:HEAT 14,repeat:HEAT 15,repeat:HEAT 2,repeat:HEAT 3,repeat:HEAT 4,repeat:HEAT 5,repeat:HEAT 6,repeat:HEAT 7,repeat:HEAT 8,repeat:HEAT 9,sequence conflict,sequence variant, Q920Q8 influenza virus NS1A binding protein(Ivns1abp) Mus musculus GO:2001243~negative regulation of intrinsic apoptotic signaling pathway, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0015629~actin cytoskeleton, GO:0005515~protein binding, IPR000210:BTB/POZ-like,IPR006652:Kelch repeat type 1,IPR011333:BTB/POZ fold,IPR011705:BTB/Kelch-associated,IPR015915:Kelch-type beta propeller,IPR015916:Galactose oxidase, beta-propeller,IPR017096:Kelch-like protein, gigaxonin, mmu05164:Influenza A, PIRSF037037:kelch-like protein, gigaxonin type, SM00225:BTB,SM00612:Kelch,SM00875:SM00875, Alternative splicing,Complete proteome,Cytoplasm,Cytoskeleton,Kelch repeat,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat, chain:Influenza virus NS1A-binding protein homolog,domain:BACK,domain:BTB,modified residue,repeat:Kelch 1,repeat:Kelch 2,repeat:Kelch 3,repeat:Kelch 4,repeat:Kelch 5,repeat:Kelch 6,sequence conflict,splice variant, Q8WND5 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein(IKBKAP) Oryctolagus cuniculus GO:0002098~tRNA wobble uridine modification,GO:0006351~transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0030335~positive regulation of cell migration, GO:0000123~histone acetyltransferase complex,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0008023~transcription elongation factor complex,GO:0033588~Elongator holoenzyme complex, GO:0008607~phosphorylase kinase regulator activity, IPR006849:IKI3,IPR011042:Six-bladed beta-propeller, TolB-like, PIRSF017233:IkappaB kinase complex, IKAP component, Complete proteome,Cytoplasm,Nucleus,Phosphoprotein,Reference proteome,Transcription,Transcription regulation, chain:Elongator complex protein 1,modified residue, Q9R0T8 inhibitor of kappaB kinase epsilon(Ikbke) Mus musculus GO:0006468~protein phosphorylation,GO:0006974~cellular response to DNA damage stimulus,GO:0008630~intrinsic apoptotic signaling pathway in response to DNA damage,GO:0010884~positive regulation of lipid storage,GO:0016310~phosphorylation,GO:0034340~response to type I interferon,GO:0035456~response to interferon-beta,GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling,GO:0051260~protein homooligomerization,GO:0098586~cellular response to virus, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0016605~PML body,GO:0031966~mitochondrial membrane, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0004704~NF-kappaB-inducing kinase activity,GO:0005524~ATP binding,GO:0008384~IkappaB kinase activity,GO:0016301~kinase activity,GO:0016740~transferase activity,GO:0031625~ubiquitin protein ligase binding,GO:0036435~K48-linked polyubiquitin binding, IPR000719:Protein kinase, catalytic domain,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, mmu04620:Toll-like receptor signaling pathway,mmu04622:RIG-I-like receptor signaling pathway,mmu04623:Cytosolic DNA-sensing pathway,mmu05160:Hepatitis C,mmu05161:Hepatitis B,mmu05162:Measles,mmu05164:Influenza A,mmu05168:Herpes simplex infection, SM00220:S_TKc, ATP-binding,Complete proteome,Cytoplasm,DNA damage,Isopeptide bond,Kinase,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Serine/threonine-protein kinase,Transferase,Ubl conjugation, active site:Proton acceptor,binding site:ATP,chain:Inhibitor of nuclear factor kappa-B kinase subunit epsilon,domain:Leucine-zipper,domain:Protein kinase,modified residue,nucleotide phosphate-binding region:ATP, P70227 inositol 1,4,5-triphosphate receptor 3(Itpr3) Mus musculus GO:0006810~transport,GO:0006811~ion transport,GO:0006816~calcium ion transport,GO:0007186~G-protein coupled receptor signaling pathway,GO:0007204~positive regulation of cytosolic calcium ion concentration,GO:0007613~memory,GO:0050913~sensory perception of bitter taste,GO:0050916~sensory perception of sweet taste,GO:0050917~sensory perception of umami taste,GO:0051260~protein homooligomerization,GO:0051291~protein heterooligomerization,GO:0051592~response to calcium ion,GO:0055085~transmembrane transport,GO:0060291~long-term synaptic potentiation,GO:0060402~calcium ion transport into cytosol,GO:0070588~calcium ion transmembrane transport,GO:0071320~cellular response to cAMP, GO:0005634~nucleus,GO:0005635~nuclear envelope,GO:0005640~nuclear outer membrane,GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005783~endoplasmic reticulum,GO:0005789~endoplasmic reticulum membrane,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0005903~brush border,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0016529~sarcoplasmic reticulum,GO:0030425~dendrite,GO:0030667~secretory granule membrane,GO:0043025~neuronal cell body,GO:0043209~myelin sheath,GO:0043235~receptor complex,GO:0045177~apical part of cell,GO:0048471~perinuclear region of cytoplasm, GO:0000822~inositol hexakisphosphate binding,GO:0005216~ion channel activity,GO:0005220~inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity,GO:0005262~calcium channel activity,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0015278~calcium-release channel activity,GO:0035091~phosphatidylinositol binding,GO:0043533~inositol 1,3,4,5 tetrakisphosphate binding,GO:0070679~inositol 1,4,5 trisphosphate binding, IPR000493:Inositol 1,4,5-trisphosphate-binding protein receptor,IPR000699:Intracellular calcium-release channel,IPR005821:Ion transport domain,IPR013662:RyR/IP3R Homology associated domain,IPR014821:Inositol 1,4,5-trisphosphate/ryanodine receptor,IPR015925:Ryanodine receptor-related,IPR016093:MIR motif, mmu04020:Calcium signaling pathway,mmu04022:cGMP-PKG signaling pathway,mmu04070:Phosphatidylinositol signaling system,mmu04114:Oocyte meiosis,mmu04270:Vascular smooth muscle contraction,mmu04540:Gap junction,mmu04611:Platelet activation,mmu04713:Circadian entrainment,mmu04720:Long-term potentiation,mmu04723:Retrograde endocannabinoid signaling,mmu04724:Glutamatergic synapse,mmu04725:Cholinergic synapse,mmu04726:Serotonergic synapse,mmu04728:Dopaminergic synapse,mmu04730:Long-term depression,mmu04742:Taste transduction,mmu04750:Inflammatory mediator regulation of TRP channels,mmu04911:Insulin secretion,mmu04912:GnRH signaling pathway,mmu04915:Estrogen signaling pathway,mmu04918:Thyroid hormone synthesis,mmu04921:Oxytocin signaling pathway,mmu04922:Glucagon signaling pathway,mmu04924:Renin secretion,mmu04925:Aldosterone synthesis and secretion,mmu04970:Salivary secretion,mmu04971:Gastric acid secretion,mmu04972:Pancreatic secretion,mmu05010:Alzheimer's disease,mmu05205:Proteoglycans in cancer, SM00472:MIR, 3D-structure,Calcium,Calcium channel,Calcium transport,Complete proteome,Endoplasmic reticulum,Ion channel,Ion transport,Ligand-gated ion channel,Membrane,Phosphoprotein,Receptor,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Transport, chain:Inositol 1,4,5-trisphosphate receptor type 3,domain:MIR 1,domain:MIR 2,domain:MIR 3,domain:MIR 4,domain:MIR 5,modified residue,mutagenesis site,sequence conflict,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, P11881 inositol 1,4,5-trisphosphate receptor 1(Itpr1) Mus musculus GO:0001666~response to hypoxia,GO:0006810~transport,GO:0006811~ion transport,GO:0006816~calcium ion transport,GO:0006915~apoptotic process,GO:0007204~positive regulation of cytosolic calcium ion concentration,GO:0009791~post-embryonic development,GO:0032469~endoplasmic reticulum calcium ion homeostasis,GO:0042045~epithelial fluid transport,GO:0050849~negative regulation of calcium-mediated signaling,GO:0050882~voluntary musculoskeletal movement,GO:0051209~release of sequestered calcium ion into cytosol,GO:0051928~positive regulation of calcium ion transport,GO:0055085~transmembrane transport,GO:0070059~intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress,GO:0070588~calcium ion transmembrane transport,GO:0071320~cellular response to cAMP,GO:1901215~negative regulation of neuron death, GO:0005635~nuclear envelope,GO:0005637~nuclear inner membrane,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005783~endoplasmic reticulum,GO:0005789~endoplasmic reticulum membrane,GO:0005886~plasma membrane,GO:0005955~calcineurin complex,GO:0014069~postsynaptic density,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0016529~sarcoplasmic reticulum,GO:0030425~dendrite,GO:0030667~secretory granule membrane,GO:0031088~platelet dense granule membrane,GO:0031094~platelet dense tubular network,GO:0043025~neuronal cell body,GO:0043231~intracellular membrane-bounded organelle,GO:0043234~protein complex,GO:0045121~membrane raft,GO:0048471~perinuclear region of cytoplasm,GO:0097060~synaptic membrane, GO:0005216~ion channel activity,GO:0005220~inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity,GO:0005262~calcium channel activity,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0008022~protein C-terminus binding,GO:0015278~calcium-release channel activity,GO:0019855~calcium channel inhibitor activity,GO:0019903~protein phosphatase binding,GO:0032403~protein complex binding,GO:0035091~phosphatidylinositol binding,GO:0070679~inositol 1,4,5 trisphosphate binding, IPR000493:Inositol 1,4,5-trisphosphate-binding protein receptor,IPR000699:Intracellular calcium-release channel,IPR005821:Ion transport domain,IPR013662:RyR/IP3R Homology associated domain,IPR014821:Inositol 1,4,5-trisphosphate/ryanodine receptor,IPR015925:Ryanodine receptor-related,IPR016093:MIR motif, mmu04020:Calcium signaling pathway,mmu04022:cGMP-PKG signaling pathway,mmu04070:Phosphatidylinositol signaling system,mmu04114:Oocyte meiosis,mmu04270:Vascular smooth muscle contraction,mmu04540:Gap junction,mmu04611:Platelet activation,mmu04713:Circadian entrainment,mmu04720:Long-term potentiation,mmu04723:Retrograde endocannabinoid signaling,mmu04724:Glutamatergic synapse,mmu04725:Cholinergic synapse,mmu04726:Serotonergic synapse,mmu04728:Dopaminergic synapse,mmu04730:Long-term depression,mmu04750:Inflammatory mediator regulation of TRP channels,mmu04912:GnRH signaling pathway,mmu04915:Estrogen signaling pathway,mmu04918:Thyroid hormone synthesis,mmu04921:Oxytocin signaling pathway,mmu04922:Glucagon signaling pathway,mmu04924:Renin secretion,mmu04925:Aldosterone synthesis and secretion,mmu04970:Salivary secretion,mmu04971:Gastric acid secretion,mmu04972:Pancreatic secretion,mmu05010:Alzheimer's disease,mmu05016:Huntington's disease,mmu05205:Proteoglycans in cancer, SM00472:MIR, 3D-structure,Alternative splicing,Apoptosis,Calcium,Calcium channel,Calcium transport,Coiled coil,Complete proteome,Direct protein sequencing,Endoplasmic reticulum,Ion channel,Ion transport,Isopeptide bond,Ligand-gated ion channel,Membrane,Phosphoprotein,Proteomics identification,Receptor,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Transport,Ubl conjugation, chain:Inositol 1,4,5-trisphosphate receptor type 1,domain:MIR 1,domain:MIR 2,domain:MIR 3,domain:MIR 4,domain:MIR 5,helix,modified residue,mutagenesis site,region of interest:Interaction with ERP44,sequence conflict,splice variant,strand,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region,turn, P29218 inositol monophosphatase 1(IMPA1) Homo sapiens GO:0006020~inositol metabolic process,GO:0006021~inositol biosynthetic process,GO:0006661~phosphatidylinositol biosynthetic process,GO:0006796~phosphate-containing compound metabolic process,GO:0007165~signal transduction,GO:0043647~inositol phosphate metabolic process,GO:0046854~phosphatidylinositol phosphorylation,GO:0046855~inositol phosphate dephosphorylation, GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0070062~extracellular exosome, GO:0000287~magnesium ion binding,GO:0005515~protein binding,GO:0008934~inositol monophosphate 1-phosphatase activity,GO:0030145~manganese ion binding,GO:0031403~lithium ion binding,GO:0042802~identical protein binding,GO:0042803~protein homodimerization activity,GO:0052832~inositol monophosphate 3-phosphatase activity,GO:0052833~inositol monophosphate 4-phosphatase activity,GO:0052834~inositol monophosphate phosphatase activity, IPR000760:Inositol monophosphatase,IPR020550:Inositol monophosphatase, conserved site,IPR020552:Inositol monophosphatase, Lithium-sensitive,IPR020583:Inositol monophosphatase, metal-binding site, hsa00562:Inositol phosphate metabolism,hsa01100:Metabolic pathways,hsa04070:Phosphatidylinositol signaling system, 3D-structure,Alternative splicing,Complete proteome,Cytoplasm,Hydrolase,Lithium,Magnesium,Metal-binding,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, binding site:Substrate,chain:Inositol monophosphatase 1,helix,metal ion-binding site:Magnesium 1,metal ion-binding site:Magnesium 1; via carbonyl oxygen,metal ion-binding site:Magnesium 2,mutagenesis site,region of interest:Substrate binding,sequence variant,strand,turn, P35570 insulin receptor substrate 1(Irs1) Rattus norvegicus GO:0002053~positive regulation of mesenchymal cell proliferation,GO:0007568~aging,GO:0008286~insulin receptor signaling pathway,GO:0010468~regulation of gene expression,GO:0010907~positive regulation of glucose metabolic process,GO:0014065~phosphatidylinositol 3-kinase signaling,GO:0014823~response to activity,GO:0016042~lipid catabolic process,GO:0030073~insulin secretion,GO:0030335~positive regulation of cell migration,GO:0030879~mammary gland development,GO:0031000~response to caffeine,GO:0032000~positive regulation of fatty acid beta-oxidation,GO:0032868~response to insulin,GO:0032869~cellular response to insulin stimulus,GO:0034504~protein localization to nucleus,GO:0042327~positive regulation of phosphorylation,GO:0043434~response to peptide hormone,GO:0043491~protein kinase B signaling,GO:0043552~positive regulation of phosphatidylinositol 3-kinase activity,GO:0045725~positive regulation of glycogen biosynthetic process,GO:0046326~positive regulation of glucose import,GO:0046627~negative regulation of insulin receptor signaling pathway,GO:0046628~positive regulation of insulin receptor signaling pathway,GO:0046676~negative regulation of insulin secretion,GO:0048009~insulin-like growth factor receptor signaling pathway,GO:0051291~protein heterooligomerization,GO:0060397~JAK-STAT cascade involved in growth hormone signaling pathway,GO:0070094~positive regulation of glucagon secretion,GO:0071478~cellular response to radiation,GO:0090275~negative regulation of somatostatin secretion,GO:1904385~cellular response to angiotensin,GO:1990416~cellular response to brain-derived neurotrophic factor stimulus,GO:2001275~positive regulation of glucose import in response to insulin stimulus, GO:0005622~intracellular,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005899~insulin receptor complex,GO:0005901~caveola,GO:0036064~ciliary basal body,GO:0043231~intracellular membrane-bounded organelle, GO:0005068~transmembrane receptor protein tyrosine kinase adaptor activity,GO:0005080~protein kinase C binding,GO:0005158~insulin receptor binding,GO:0005159~insulin-like growth factor receptor binding,GO:0005515~protein binding,GO:0019901~protein kinase binding,GO:0019904~protein domain specific binding,GO:0042169~SH2 domain binding,GO:0043548~phosphatidylinositol 3-kinase binding, IPR001849:Pleckstrin homology domain,IPR002404:Insulin receptor substrate-1, PTB,IPR011993:Pleckstrin homology-like domain, rno04022:cGMP-PKG signaling pathway,rno04068:FoxO signaling pathway,rno04150:mTOR signaling pathway,rno04151:PI3K-Akt signaling pathway,rno04152:AMPK signaling pathway,rno04722:Neurotrophin signaling pathway,rno04910:Insulin signaling pathway,rno04920:Adipocytokine signaling pathway,rno04923:Regulation of lipolysis in adipocytes,rno04930:Type II diabetes mellitus,rno04931:Insulin resistance,rno04932:Non-alcoholic fatty liver disease (NAFLD),rno04960:Aldosterone-regulated sodium reabsorption,rno05206:MicroRNAs in cancer, SM00233:PH,SM00310:PTBI, Complete proteome,Direct protein sequencing,Phosphoprotein,Proteomics identification,Receptor,Reference proteome,Repeat,Transducer,Ubl conjugation, chain:Insulin receptor substrate 1,compositionally biased region:Poly-Gln,compositionally biased region:Poly-Pro,domain:IRS-type PTB,domain:PH,modified residue,region of interest:GRB2-binding,sequence conflict,short sequence motif:YXXM motif 1,short sequence motif:YXXM motif 2,short sequence motif:YXXM motif 3,short sequence motif:YXXM motif 4,short sequence motif:YXXM motif 5,short sequence motif:YXXM motif 6,short sequence motif:YXXM motif 7,short sequence motif:YXXM motif 8,short sequence motif:YXXM motif 9, Q96HW7 integrator complex subunit 4(INTS4) Homo sapiens GO:0016180~snRNA processing,GO:0042795~snRNA transcription from RNA polymerase II promoter, GO:0005654~nucleoplasm,GO:0032039~integrator complex, GO:0005515~protein binding, IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold,IPR026003:HEAT repeat associated with sister chromatid cohesion protein, Acetylation,Alternative splicing,Complete proteome,Isopeptide bond,Nucleus,Proteomics identification,Reference proteome,Repeat,Ubl conjugation, chain:Integrator complex subunit 4,modified residue,repeat:HEAT 1,repeat:HEAT 2,repeat:HEAT 3,repeat:HEAT 4,repeat:HEAT 5,repeat:HEAT 6,repeat:HEAT 7,repeat:HEAT 8,sequence conflict,splice variant, Q61739 integrin alpha 6(Itga6) Mus musculus GO:0007155~cell adhesion,GO:0007160~cell-matrix adhesion,GO:0007229~integrin-mediated signaling pathway,GO:0010668~ectodermal cell differentiation,GO:0010811~positive regulation of cell-substrate adhesion,GO:0016337~single organismal cell-cell adhesion,GO:0022409~positive regulation of cell-cell adhesion,GO:0030335~positive regulation of cell migration,GO:0031589~cell-substrate adhesion,GO:0031668~cellular response to extracellular stimulus,GO:0033627~cell adhesion mediated by integrin,GO:0035878~nail development,GO:0042327~positive regulation of phosphorylation,GO:0042475~odontogenesis of dentin-containing tooth,GO:0043065~positive regulation of apoptotic process,GO:0043547~positive regulation of GTPase activity,GO:0043588~skin development,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0046847~filopodium assembly,GO:0048565~digestive tract development,GO:0050873~brown fat cell differentiation,GO:0050900~leukocyte migration,GO:0071407~cellular response to organic cyclic compound,GO:0072001~renal system development,GO:0097186~amelogenesis,GO:2001237~negative regulation of extrinsic apoptotic signaling pathway, GO:0005604~basement membrane,GO:0005886~plasma membrane,GO:0005913~cell-cell adherens junction,GO:0005925~focal adhesion,GO:0008305~integrin complex,GO:0009897~external side of plasma membrane,GO:0009925~basal plasma membrane,GO:0009986~cell surface,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0016323~basolateral plasma membrane,GO:0030056~hemidesmosome,GO:0030175~filopodium,GO:0034676~integrin alpha6-beta4 complex,GO:0045178~basal part of cell, GO:0005178~integrin binding,GO:0005515~protein binding,GO:0031994~insulin-like growth factor I binding,GO:0032403~protein complex binding,GO:0038132~neuregulin binding,GO:0043236~laminin binding,GO:0046872~metal ion binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000413:Integrin alpha chain,IPR013519:Integrin alpha beta-propellor,IPR013649:Integrin alpha-2,IPR018184:Integrin alpha chain, C-terminal cytoplasmic region, conserved site, mmu04151:PI3K-Akt signaling pathway,mmu04510:Focal adhesion,mmu04512:ECM-receptor interaction,mmu04514:Cell adhesion molecules (CAMs),mmu04640:Hematopoietic cell lineage,mmu04810:Regulation of actin cytoskeleton,mmu05145:Toxoplasmosis,mmu05200:Pathways in cancer,mmu05222:Small cell lung cancer,mmu05410:Hypertrophic cardiomyopathy (HCM),mmu05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC),mmu05414:Dilated cardiomyopathy, SM00191:Int_alpha, Alternative splicing,Calcium,Cell adhesion,Cell membrane,Cleavage on pair of basic residues,Complete proteome,Disulfide bond,Glycoprotein,Integrin,Lipoprotein,Membrane,Metal-binding,Palmitate,Phosphoprotein,Proteomics identification,Receptor,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Integrin alpha-6,chain:Integrin alpha-6 heavy chain,chain:Integrin alpha-6 light chain,disulfide bond,glycosylation site:N-linked (GlcNAc...),repeat:FG-GAP 1,repeat:FG-GAP 2,repeat:FG-GAP 3,repeat:FG-GAP 4,repeat:FG-GAP 5,repeat:FG-GAP 6,repeat:FG-GAP 7,short sequence motif:GFFKR motif,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, E9Q286 interactor of little elongation complex ELL subunit 1(Ice1) Mus musculus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0031334~positive regulation of protein complex assembly,GO:0042795~snRNA transcription from RNA polymerase II promoter,GO:0042796~snRNA transcription from RNA polymerase III promoter,GO:0045945~positive regulation of transcription from RNA polymerase III promoter,GO:0090316~positive regulation of intracellular protein transport, GO:0005634~nucleus,GO:0008023~transcription elongation factor complex,GO:0015030~Cajal body,GO:0035327~transcriptionally active chromatin,GO:0035363~histone locus body, Acetylation,Coiled coil,Complete proteome,Nucleus,Phosphoprotein,Reference proteome,Transcription,Transcription regulation, Q61371 intraflagellar transport 88(Ift88) Mus musculus GO:0001654~eye development,GO:0001822~kidney development,GO:0001886~endothelial cell morphogenesis,GO:0001889~liver development,GO:0003382~epithelial cell morphogenesis,GO:0007219~Notch signaling pathway,GO:0007224~smoothened signaling pathway,GO:0007288~sperm axoneme assembly,GO:0007290~spermatid nucleus elongation,GO:0007368~determination of left/right symmetry,GO:0007399~nervous system development,GO:0007420~brain development,GO:0007507~heart development,GO:0008104~protein localization,GO:0008544~epidermis development,GO:0008589~regulation of smoothened signaling pathway,GO:0009887~organ morphogenesis,GO:0009952~anterior/posterior pattern specification,GO:0009953~dorsal/ventral pattern formation,GO:0021513~spinal cord dorsal/ventral patterning,GO:0021537~telencephalon development,GO:0030030~cell projection organization,GO:0030324~lung development,GO:0031016~pancreas development,GO:0031122~cytoplasmic microtubule organization,GO:0034405~response to fluid shear stress,GO:0035058~nonmotile primary cilium assembly,GO:0036334~epidermal stem cell homeostasis,GO:0042384~cilium assembly,GO:0042487~regulation of odontogenesis of dentin-containing tooth,GO:0042733~embryonic digit morphogenesis,GO:0043568~positive regulation of insulin-like growth factor receptor signaling pathway,GO:0045598~regulation of fat cell differentiation,GO:0048853~forebrain morphogenesis,GO:0050680~negative regulation of epithelial cell proliferation,GO:0055007~cardiac muscle cell differentiation,GO:0060021~palate development,GO:0060122~inner ear receptor stereocilium organization,GO:0060173~limb development,GO:0060259~regulation of feeding behavior,GO:0060271~cilium morphogenesis,GO:0060411~cardiac septum morphogenesis,GO:0060426~lung vasculature development,GO:0060914~heart formation,GO:0061351~neural precursor cell proliferation,GO:0070613~regulation of protein processing,GO:0090102~cochlea development,GO:1902017~regulation of cilium assembly,GO:2000785~regulation of autophagosome assembly, GO:0002080~acrosomal membrane,GO:0002081~outer acrosomal membrane,GO:0005737~cytoplasm,GO:0005802~trans-Golgi network,GO:0005813~centrosome,GO:0005814~centriole,GO:0005856~cytoskeleton,GO:0005929~cilium,GO:0005930~axoneme,GO:0030992~intraciliary transport particle B,GO:0031512~motile primary cilium,GO:0031514~motile cilium,GO:0032391~photoreceptor connecting cilium,GO:0036064~ciliary basal body,GO:0042995~cell projection,GO:0045177~apical part of cell,GO:0060091~kinocilium,GO:0072372~primary cilium,GO:0097541~axonemal basal plate,GO:0097542~ciliary tip,GO:0097546~ciliary base, GO:0005515~protein binding,GO:0019894~kinesin binding, IPR011990:Tetratricopeptide-like helical,IPR013026:Tetratricopeptide repeat-containing domain,IPR019734:Tetratricopeptide repeat, SM00028:TPR, Cell projection,Cilium,Cilium biogenesis/degradation,Complete proteome,Cytoplasm,Cytoskeleton,Flagellum,Proteomics identification,Reference proteome,Repeat,TPR repeat, chain:Intraflagellar transport protein 88 homolog,repeat:TPR 1,repeat:TPR 10,repeat:TPR 11,repeat:TPR 2,repeat:TPR 3,repeat:TPR 4,repeat:TPR 5,repeat:TPR 6,repeat:TPR 7,repeat:TPR 8,repeat:TPR 9,sequence conflict, Q27J81 inverted formin, FH2 and WH2 domain containing(INF2) Homo sapiens GO:0030036~actin cytoskeleton organization,GO:0090140~regulation of mitochondrial fission, GO:0048471~perinuclear region of cytoplasm, GO:0003779~actin binding,GO:0017048~Rho GTPase binding, IPR003124:WH2 domain,IPR010472:Diaphanous FH3,IPR010473:Diaphanous GTPase-binding,IPR014768:GTPase-binding/formin homology 3,IPR015425:Actin-binding FH2,IPR016024:Armadillo-type fold, 613237~Glomerulosclerosis, focal segmental, 5,614455~Charcot-Marie-Tooth disease, dominant intermediate E, SM00498:FH2,SM01139:SM01139,SM01140:SM01140, Acetylation,Actin-binding,Alternative splicing,Charcot-Marie-Tooth disease,Coiled coil,Complete proteome,Cytoplasm,Direct protein sequencing,Disease mutation,Neurodegeneration,Neuropathy,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:Inverted formin-2,compositionally biased region:Poly-Ala,compositionally biased region:Pro-rich,domain:FH2,domain:GBD/FH3,domain:WH2,modified residue,sequence conflict,sequence variant,splice variant, A2CG49 kalirin, RhoGEF kinase(Kalrn) Mus musculus GO:0001662~behavioral fear response,GO:0006468~protein phosphorylation,GO:0007266~Rho protein signal transduction,GO:0007399~nervous system development,GO:0007409~axonogenesis,GO:0007528~neuromuscular junction development,GO:0007595~lactation,GO:0007613~memory,GO:0008344~adult locomotory behavior,GO:0009612~response to mechanical stimulus,GO:0014909~smooth muscle cell migration,GO:0016310~phosphorylation,GO:0035023~regulation of Rho protein signal transduction,GO:0035176~social behavior,GO:0035556~intracellular signal transduction,GO:0042711~maternal behavior,GO:0043547~positive regulation of GTPase activity,GO:0046959~habituation,GO:0048148~behavioral response to cocaine,GO:0048168~regulation of neuronal synaptic plasticity,GO:0048659~smooth muscle cell proliferation,GO:0050773~regulation of dendrite development,GO:0051966~regulation of synaptic transmission, glutamatergic,GO:0060125~negative regulation of growth hormone secretion,GO:0060137~maternal process involved in parturition,GO:0060999~positive regulation of dendritic spine development,GO:0061003~positive regulation of dendritic spine morphogenesis,GO:0061368~behavioral response to formalin induced pain,GO:1900273~positive regulation of long-term synaptic potentiation,GO:1903076~regulation of protein localization to plasma membrane, GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0014069~postsynaptic density,GO:0043005~neuron projection,GO:0043025~neuronal cell body,GO:0048471~perinuclear region of cytoplasm,GO:0070062~extracellular exosome, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005085~guanyl-nucleotide exchange factor activity,GO:0005089~Rho guanyl-nucleotide exchange factor activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0016740~transferase activity,GO:0019899~enzyme binding,GO:0030676~Rac guanyl-nucleotide exchange factor activity,GO:0046872~metal ion binding, IPR000219:Dbl homology (DH) domain,IPR000719:Protein kinase, catalytic domain,IPR001251:CRAL-TRIO domain,IPR001452:Src homology-3 domain,IPR001849:Pleckstrin homology domain,IPR002017:Spectrin repeat,IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR003961:Fibronectin, type III,IPR007110:Immunoglobulin-like domain,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR011993:Pleckstrin homology-like domain,IPR013098:Immunoglobulin I-set,IPR013783:Immunoglobulin-like fold,IPR017441:Protein kinase, ATP binding site,IPR018159:Spectrin/alpha-actinin, SM00060:FN3,SM00150:SPEC,SM00220:S_TKc,SM00233:PH,SM00325:RhoGEF,SM00326:SH3,SM00408:IGc2,SM00409:IG,SM00516:SEC14, 3D-structure,Alternative initiation,Alternative splicing,ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Disulfide bond,Guanine-nucleotide releasing factor,Immunoglobulin domain,Kinase,Magnesium,Metal-binding,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Serine/threonine-protein kinase,SH3 domain,Transferase, active site:Proton acceptor,binding site:ATP,chain:Kalirin,compositionally biased region:Poly-Gln,disulfide bond,domain:CRAL-TRIO,domain:DH 1,domain:DH 2,domain:Fibronectin type-III,domain:Ig-like C2-type,domain:PH 1,domain:PH 2,domain:Protein kinase,domain:SH3 1,domain:SH3 2,modified residue,nucleotide phosphate-binding region:ATP,repeat:Spectrin 1,repeat:Spectrin 2,repeat:Spectrin 3,repeat:Spectrin 4,repeat:Spectrin 5,sequence conflict,splice variant,strand, O61577 katanin p60(KATNA1) Strongylocentrotus purpuratus GO:0007067~mitotic nuclear division,GO:0031122~cytoplasmic microtubule organization,GO:0051013~microtubule severing,GO:0051301~cell division, GO:0000922~spindle pole,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005819~spindle,GO:0005874~microtubule,GO:0030496~midbody, GO:0005524~ATP binding,GO:0008568~microtubule-severing ATPase activity, IPR003593:AAA+ ATPase domain,IPR003959:ATPase, AAA-type, core,IPR003960:ATPase, AAA-type, conserved site,IPR015415:Vps4 oligomerisation, C-terminal,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00382:AAA, ATP-binding,Cell cycle,Cell division,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Hydrolase,Microtubule,Mitosis,Nucleotide-binding,Reference proteome, chain:Katanin p60 ATPase-containing subunit,mutagenesis site,nucleotide phosphate-binding region:ATP, O95198 kelch like family member 2(KLHL2) Homo sapiens GO:0016567~protein ubiquitination, GO:0001726~ruffle,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0015629~actin cytoskeleton,GO:0016021~integral component of membrane,GO:0030027~lamellipodium,GO:0031463~Cul3-RING ubiquitin ligase complex, GO:0003779~actin binding,GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0042802~identical protein binding, IPR000210:BTB/POZ-like,IPR006652:Kelch repeat type 1,IPR011333:BTB/POZ fold,IPR011705:BTB/Kelch-associated,IPR015916:Galactose oxidase, beta-propeller,IPR017096:Kelch-like protein, gigaxonin, PIRSF037037:kelch-like protein, gigaxonin type, SM00225:BTB,SM00612:Kelch,SM00875:SM00875, 3D-structure,Actin-binding,Alternative splicing,Cell projection,Complete proteome,Cytoplasm,Cytoskeleton,Kelch repeat,Membrane,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Ubl conjugation pathway, chain:Kelch-like protein 2,domain:BTB,repeat:Kelch 1,repeat:Kelch 2,repeat:Kelch 3,repeat:Kelch 4,repeat:Kelch 5,repeat:Kelch 6,sequence conflict, Q6TFL4 kelch like family member 24(KLHL24) Homo sapiens GO:0016567~protein ubiquitination,GO:2000312~regulation of kainate selective glutamate receptor activity, GO:0005737~cytoplasm,GO:0030424~axon,GO:0031463~Cul3-RING ubiquitin ligase complex,GO:0043204~perikaryon, GO:0004842~ubiquitin-protein transferase activity, IPR000210:BTB/POZ-like,IPR006652:Kelch repeat type 1,IPR011333:BTB/POZ fold,IPR011705:BTB/Kelch-associated,IPR015916:Galactose oxidase, beta-propeller,IPR017096:Kelch-like protein, gigaxonin, PIRSF037037:kelch-like protein, gigaxonin type, SM00225:BTB,SM00612:Kelch,SM00875:SM00875, Alternative splicing,Cell projection,Complete proteome,Cytoplasm,Kelch repeat,Proteomics identification,Reference proteome,Repeat, chain:Kelch-like protein 24,domain:BACK,domain:BTB,repeat:Kelch 1,repeat:Kelch 2,repeat:Kelch 3,repeat:Kelch 4,repeat:Kelch 5,repeat:Kelch 6,sequence conflict,splice variant, E0CZ16 kelch-like 3(Klhl3) Mus musculus GO:0016567~protein ubiquitination,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process,GO:0050801~ion homeostasis,GO:0070294~renal sodium ion absorption,GO:0070936~protein K48-linked ubiquitination,GO:0072156~distal tubule morphogenesis, GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005856~cytoskeleton,GO:0031463~Cul3-RING ubiquitin ligase complex, GO:0003779~actin binding,GO:0003824~catalytic activity,GO:0004842~ubiquitin-protein transferase activity, IPR000210:BTB/POZ-like,IPR006652:Kelch repeat type 1,IPR011041:Soluble quinoprotein glucose/sorbosone dehydrogenase,IPR011333:BTB/POZ fold,IPR011705:BTB/Kelch-associated,IPR015916:Galactose oxidase, beta-propeller,IPR017096:Kelch-like protein, gigaxonin, PIRSF037037:kelch-like protein, gigaxonin type, SM00225:BTB,SM00612:Kelch,SM00875:SM00875, Actin-binding,Alternative splicing,Complete proteome,Cytoplasm,Cytoskeleton,Kelch repeat,Proteomics identification,Reference proteome,Repeat,Ubl conjugation pathway, Q5U374 kelch-like family member 12(klhl12) Danio rerio GO:0006513~protein monoubiquitination,GO:0006810~transport,GO:0006888~ER to Golgi vesicle-mediated transport,GO:0007275~multicellular organism development,GO:0009952~anterior/posterior pattern specification,GO:0016055~Wnt signaling pathway,GO:0016192~vesicle-mediated transport,GO:0048208~COPII vesicle coating,GO:0060028~convergent extension involved in axis elongation, GO:0000139~Golgi membrane,GO:0030134~ER to Golgi transport vesicle,GO:0031410~cytoplasmic vesicle,GO:0031463~Cul3-RING ubiquitin ligase complex, GO:0004842~ubiquitin-protein transferase activity, IPR000210:BTB/POZ-like,IPR006652:Kelch repeat type 1,IPR011333:BTB/POZ fold,IPR011705:BTB/Kelch-associated,IPR015916:Galactose oxidase, beta-propeller,IPR017096:Kelch-like protein, gigaxonin, PIRSF037037:kelch-like protein, gigaxonin type, SM00225:BTB,SM00612:Kelch,SM00875:SM00875, Complete proteome,Cytoplasmic vesicle,Developmental protein,ER-Golgi transport,Kelch repeat,Reference proteome,Repeat,Transport,Ubl conjugation pathway,Wnt signaling pathway, chain:Kelch-like protein 12,domain:BTB,repeat:Kelch 1,repeat:Kelch 2,repeat:Kelch 3,repeat:Kelch 4,repeat:Kelch 5,repeat:Kelch 6, F1LZF0 kelch-like family member 2(Klhl2) Rattus norvegicus GO:0016567~protein ubiquitination, GO:0001726~ruffle,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0015629~actin cytoskeleton,GO:0030027~lamellipodium,GO:0031463~Cul3-RING ubiquitin ligase complex, GO:0003779~actin binding,GO:0004842~ubiquitin-protein transferase activity, IPR000210:BTB/POZ-like,IPR006652:Kelch repeat type 1,IPR011333:BTB/POZ fold,IPR011705:BTB/Kelch-associated,IPR015916:Galactose oxidase, beta-propeller,IPR017096:Kelch-like protein, gigaxonin, PIRSF037037:kelch-like protein, gigaxonin type, SM00225:BTB,SM00612:Kelch,SM00875:SM00875, Actin-binding,Cell projection,Complete proteome,Cytoplasm,Cytoskeleton,Kelch repeat,Reference proteome,Repeat,Ubl conjugation pathway, F1LZ52 kelch-like family member 3(Klhl3) Rattus norvegicus GO:0016567~protein ubiquitination,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process,GO:0050801~ion homeostasis,GO:0070294~renal sodium ion absorption,GO:0070936~protein K48-linked ubiquitination,GO:0072156~distal tubule morphogenesis, GO:0005829~cytosol,GO:0005856~cytoskeleton,GO:0031463~Cul3-RING ubiquitin ligase complex, GO:0003779~actin binding,GO:0004842~ubiquitin-protein transferase activity, IPR000210:BTB/POZ-like,IPR006652:Kelch repeat type 1,IPR011333:BTB/POZ fold,IPR011705:BTB/Kelch-associated,IPR015916:Galactose oxidase, beta-propeller,IPR017096:Kelch-like protein, gigaxonin, PIRSF037037:kelch-like protein, gigaxonin type, SM00225:BTB,SM00612:Kelch,SM00875:SM00875, Actin-binding,Complete proteome,Cytoplasm,Cytoskeleton,Kelch repeat,Reference proteome,Repeat,Ubl conjugation pathway, E7F6F9 kelch-like family member 3(klhl3) Danio rerio GO:0016567~protein ubiquitination,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process,GO:0050801~ion homeostasis,GO:0070294~renal sodium ion absorption,GO:0070936~protein K48-linked ubiquitination,GO:0072156~distal tubule morphogenesis, GO:0005829~cytosol,GO:0005856~cytoskeleton,GO:0031463~Cul3-RING ubiquitin ligase complex, IPR000210:BTB/POZ-like,IPR006652:Kelch repeat type 1,IPR011043:Galactose oxidase/kelch, beta-propeller,IPR011333:BTB/POZ fold,IPR011705:BTB/Kelch-associated,IPR015916:Galactose oxidase, beta-propeller,IPR017096:Kelch-like protein, gigaxonin, PIRSF037037:kelch-like protein, gigaxonin type, SM00225:BTB,SM00612:Kelch,SM00875:SM00875, Actin-binding,Complete proteome,Cytoplasm,Cytoskeleton,Kelch repeat,Reference proteome,Repeat,Ubl conjugation pathway, Q9IBG7 kielin/chordin-like protein L homeolog(kcp.L) Xenopus laevis GO:0005576~extracellular region, IPR001007:von Willebrand factor, type C,IPR001791:Laminin G domain,IPR001846:von Willebrand factor, type D domain,IPR002919:Trypsin Inhibitor-like, cysteine rich domain,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR014853:Uncharacterised domain, cysteine-rich, SM00210:TSPN,SM00214:VWC,SM00215:VWC_out,SM00216:VWD,SM00832:SM00832, Coiled coil,Disulfide bond,Repeat,Secreted,Signal, chain:Kielin/chordin-like protein,compositionally biased region:Poly-Gln,compositionally biased region:Poly-Ser,disulfide bond,domain:TIL,domain:VWFC 1,domain:VWFC 10,domain:VWFC 11,domain:VWFC 12,domain:VWFC 13,domain:VWFC 14,domain:VWFC 15,domain:VWFC 16,domain:VWFC 17,domain:VWFC 18,domain:VWFC 19,domain:VWFC 2,domain:VWFC 20,domain:VWFC 21,domain:VWFC 22,domain:VWFC 23,domain:VWFC 24,domain:VWFC 25,domain:VWFC 26,domain:VWFC 27,domain:VWFC 28,domain:VWFC 3,domain:VWFC 4,domain:VWFC 5,domain:VWFC 6,domain:VWFC 7,domain:VWFC 8,domain:VWFC 9,domain:VWFD,signal peptide, Q6VAB6 kinase suppressor of ras 2(KSR2) Homo sapiens GO:0006468~protein phosphorylation,GO:0035556~intracellular signal transduction, GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0016020~membrane, GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005524~ATP binding,GO:0046872~metal ion binding, IPR000719:Protein kinase, catalytic domain,IPR001245:Serine-threonine/tyrosine-protein kinase catalytic domain,IPR002219:Protein kinase C-like, phorbol ester/diacylglycerol binding,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR025561:Kinase suppressor of RAS, SAM-like domain, hsa04014:Ras signaling pathway, SM00109:C1,SM00220:S_TKc, 3D-structure,Alternative splicing,ATP-binding,Complete proteome,Cytoplasm,Kinase,Membrane,Metal-binding,Nucleotide-binding,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Serine/threonine-protein kinase,Transferase,Zinc,Zinc-finger, chain:Kinase suppressor of Ras 2,compositionally biased region:Pro-rich,domain:Protein kinase,metal ion-binding site:Zinc 1,metal ion-binding site:Zinc 2,modified residue,sequence variant,splice variant,zinc finger region:Phorbol-ester/DAG-type, Q96FN5 kinesin family member 12(KIF12) Homo sapiens GO:0007018~microtubule-based movement, GO:0005737~cytoplasm,GO:0005815~microtubule organizing center,GO:0005871~kinesin complex,GO:0005874~microtubule,GO:0070062~extracellular exosome, GO:0003777~microtubule motor activity,GO:0005524~ATP binding,GO:0008017~microtubule binding,GO:0016887~ATPase activity, IPR001752:Kinesin, motor domain,IPR019821:Kinesin, motor region, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00129:KISc, ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Microtubule,Motor protein,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome, chain:Kinesin-like protein KIF12,compositionally biased region:Pro-rich,domain:Kinesin-motor,nucleotide phosphate-binding region:ATP, Q9D2Z8 kinesin family member 12(Kif12) Mus musculus GO:0007018~microtubule-based movement, GO:0005737~cytoplasm,GO:0005815~microtubule organizing center,GO:0005856~cytoskeleton,GO:0005871~kinesin complex,GO:0005874~microtubule,GO:0070062~extracellular exosome, GO:0000166~nucleotide binding,GO:0003777~microtubule motor activity,GO:0005524~ATP binding,GO:0008017~microtubule binding,GO:0016887~ATPase activity, IPR001752:Kinesin, motor domain,IPR019821:Kinesin, motor region, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00129:KISc, ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Microtubule,Motor protein,Nucleotide-binding,Phosphoprotein,Reference proteome, chain:Kinesin-like protein KIF12,compositionally biased region:Pro-rich,domain:Kinesin-motor,nucleotide phosphate-binding region:ATP,sequence conflict, Q9EQW7 kinesin family member 13A(Kif13a) Mus musculus GO:0000910~cytokinesis,GO:0006810~transport,GO:0006886~intracellular protein transport,GO:0007018~microtubule-based movement,GO:0007049~cell cycle,GO:0008333~endosome to lysosome transport,GO:0015031~protein transport,GO:0032438~melanosome organization,GO:0035459~cargo loading into vesicle,GO:0043001~Golgi to plasma membrane protein transport,GO:0051301~cell division,GO:0072383~plus-end-directed vesicle transport along microtubule, GO:0005622~intracellular,GO:0005623~cell,GO:0005737~cytoplasm,GO:0005768~endosome,GO:0005794~Golgi apparatus,GO:0005813~centrosome,GO:0005856~cytoskeleton,GO:0005871~kinesin complex,GO:0005874~microtubule,GO:0010008~endosome membrane,GO:0016020~membrane,GO:0030496~midbody,GO:0032588~trans-Golgi network membrane, GO:0000166~nucleotide binding,GO:0003777~microtubule motor activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008017~microtubule binding,GO:0016887~ATPase activity, IPR000253:Forkhead-associated (FHA) domain,IPR001752:Kinesin, motor domain,IPR008984:SMAD/FHA domain,IPR019821:Kinesin, motor region, conserved site,IPR022140:Kinesin protein 1B,IPR022164:Kinesin-like,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00129:KISc, 3D-structure,ATP-binding,Cell cycle,Cell division,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Endosome,Golgi apparatus,Membrane,Microtubule,Motor protein,Nucleotide-binding,Phosphoprotein,Protein transport,Proteomics identification,Reference proteome,Transport, chain:Kinesin-like protein KIF13A,domain:FHA,domain:Kinesin-motor,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict, Q9QXL2 kinesin family member 21A(Kif21a) Mus musculus GO:0007018~microtubule-based movement, GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005871~kinesin complex,GO:0005874~microtubule,GO:0030424~axon,GO:0030425~dendrite,GO:0042995~cell projection, GO:0000166~nucleotide binding,GO:0003777~microtubule motor activity,GO:0005524~ATP binding,GO:0008017~microtubule binding,GO:0016887~ATPase activity, IPR001680:WD40 repeat,IPR001752:Kinesin, motor domain,IPR009053:Prefoldin,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site,IPR019821:Kinesin, motor region, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00129:KISc,SM00320:WD40, Acetylation,Alternative splicing,ATP-binding,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Microtubule,Motor protein,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,WD repeat, chain:Kinesin-like protein KIF21A,domain:Kinesin-motor,modified residue,nucleotide phosphate-binding region:ATP,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,sequence conflict,splice variant, Q6ZMV9 kinesin family member 6(KIF6) Homo sapiens GO:0007018~microtubule-based movement, GO:0001673~male germ cell nucleus,GO:0005737~cytoplasm,GO:0005871~kinesin complex,GO:0005874~microtubule, GO:0003777~microtubule motor activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008017~microtubule binding,GO:0016887~ATPase activity, IPR001752:Kinesin, motor domain,IPR019821:Kinesin, motor region, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00129:KISc, Alternative splicing,ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Microtubule,Motor protein,Nucleotide-binding,Polymorphism,Reference proteome, chain:Kinesin-like protein KIF6,domain:Kinesin-motor,nucleotide phosphate-binding region:ATP,sequence conflict,sequence variant,splice variant, E1C2V1 l(3)mbt-like 1 (Drosophila)(L3MBTL1) Gallus gallus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007088~regulation of mitotic nuclear division,GO:0016569~covalent chromatin modification,GO:0030097~hemopoiesis,GO:0045652~regulation of megakaryocyte differentiation,GO:0045892~negative regulation of transcription, DNA-templated, GO:0000785~chromatin,GO:0000793~condensed chromosome,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005886~plasma membrane, GO:0003682~chromatin binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0008270~zinc ion binding,GO:0035064~methylated histone binding, IPR001660:Sterile alpha motif domain,IPR002515:Zinc finger, C2HC-type,IPR004092:Mbt repeat,IPR013761:Sterile alpha motif/pointed domain, SM00454:SAM,SM00561:MBT, Chromatin regulator,Complete proteome,Metal-binding,Nucleus,Reference proteome,Repeat,Repressor,Transcription,Transcription regulation,Zinc,Zinc-finger, P83095 lactamase beta(LACTB) Bos taurus GO:0005739~mitochondrion, GO:0016787~hydrolase activity, IPR001466:Beta-lactamase-related,IPR012338:Beta-lactamase/transpeptidase-like, Acetylation,Complete proteome,Direct protein sequencing,Hydrolase,Mitochondrion,Reference proteome,Transit peptide, active site:Acyl-ester intermediate,chain:Serine beta-lactamase-like protein LACTB, mitochondrial,modified residue,transit peptide:Mitochondrion, P02469 laminin B1(Lamb1) Mus musculus GO:0007155~cell adhesion,GO:0007162~negative regulation of cell adhesion,GO:0007411~axon guidance,GO:0007566~embryo implantation,GO:0007611~learning or memory,GO:0016477~cell migration,GO:0021812~neuronal-glial interaction involved in cerebral cortex radial glia guided migration,GO:0022617~extracellular matrix disassembly,GO:0030198~extracellular matrix organization,GO:0030335~positive regulation of cell migration,GO:0031175~neuron projection development,GO:0034446~substrate adhesion-dependent cell spreading,GO:0035987~endodermal cell differentiation,GO:0042476~odontogenesis, GO:0005576~extracellular region,GO:0005578~proteinaceous extracellular matrix,GO:0005604~basement membrane,GO:0005605~basal lamina,GO:0005606~laminin-1 complex,GO:0005607~laminin-2 complex,GO:0005615~extracellular space,GO:0005634~nucleus,GO:0031012~extracellular matrix,GO:0043256~laminin complex,GO:0043257~laminin-8 complex,GO:0043259~laminin-10 complex,GO:0048471~perinuclear region of cytoplasm,GO:0070062~extracellular exosome, GO:0005178~integrin binding,GO:0005201~extracellular matrix structural constituent,GO:0005515~protein binding,GO:0019899~enzyme binding,GO:0043208~glycosphingolipid binding, IPR000742:Epidermal growth factor-like domain,IPR002049:EGF-like, laminin,IPR008211:Laminin, N-terminal,IPR009053:Prefoldin,IPR013015:Laminin IV, mmu04151:PI3K-Akt signaling pathway,mmu04510:Focal adhesion,mmu04512:ECM-receptor interaction,mmu05145:Toxoplasmosis,mmu05146:Amoebiasis,mmu05200:Pathways in cancer,mmu05222:Small cell lung cancer, SM00136:LamNT,SM00180:EGF_Lam,SM00181:EGF, 3D-structure,Basement membrane,Cell adhesion,Coiled coil,Complete proteome,Direct protein sequencing,Disulfide bond,Extracellular matrix,Glycoprotein,Laminin EGF-like domain,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Secreted,Signal, chain:Laminin subunit beta-1,disulfide bond,domain:Laminin EGF-like 1,domain:Laminin EGF-like 10,domain:Laminin EGF-like 11,domain:Laminin EGF-like 12,domain:Laminin EGF-like 13,domain:Laminin EGF-like 2,domain:Laminin EGF-like 3,domain:Laminin EGF-like 4,domain:Laminin EGF-like 5; truncated,domain:Laminin EGF-like 6,domain:Laminin EGF-like 7,domain:Laminin EGF-like 8,domain:Laminin EGF-like 9,domain:Laminin IV type B,domain:Laminin N-terminal,glycosylation site:N-linked (GlcNAc...),region of interest:Domain alpha,region of interest:Domain I,region of interest:Domain II,sequence conflict,signal peptide, Q9VR59 lethal (1) G0196(l(1)G0196) Drosophila melanogaster Coenzyme metabolism / Translation, ribosomal structure and biogenesis, GO:0006020~inositol metabolic process,GO:0032958~inositol phosphate biosynthetic process, GO:0005829~cytosol, GO:0000827~inositol-1,3,4,5,6-pentakisphosphate kinase activity,GO:0000828~inositol hexakisphosphate kinase activity,GO:0000829~inositol heptakisphosphate kinase activity,GO:0000832~inositol hexakisphosphate 5-kinase activity,GO:0003993~acid phosphatase activity,GO:0005524~ATP binding,GO:0033857~diphosphoinositol-pentakisphosphate kinase activity,GO:0052723~inositol hexakisphosphate 1-kinase activity,GO:0052724~inositol hexakisphosphate 3-kinase activity, IPR000560:Histidine phosphatase superfamily, clade-2, dme04070:Phosphatidylinositol signaling system, Alternative splicing,ATP-binding,Complete proteome,Cytoplasm,Hydrolase,Kinase,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome,RNA editing,Transferase, chain:Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase,modified residue,sequence conflict,sequence variant,splice variant, Q6NRC9 leucine rich repeat and coiled-coil centrosomal protein 1 L homeolog(lrrcc1.L) Xenopus laevis GO:0007067~mitotic nuclear division,GO:0051301~cell division, GO:0005814~centriole, IPR001611:Leucine-rich repeat,IPR003591:Leucine-rich repeat, typical subtype,IPR025875:Leucine rich repeat 4, SM00369:LRR_TYP, Cell cycle,Cell division,Coiled coil,Cytoplasm,Cytoskeleton,Leucine-rich repeat,Mitosis,Repeat, chain:Leucine-rich repeat and coiled-coil domain-containing protein 1,repeat:LRR 1,repeat:LRR 2,repeat:LRR 3,repeat:LRR 4,repeat:LRR 5,repeat:LRR 6, Q80TE7 leucine rich repeat containing 7(Lrrc7) Mus musculus Function unknown, GO:0010976~positive regulation of neuron projection development, GO:0005737~cytoplasm,GO:0005789~endoplasmic reticulum membrane,GO:0005886~plasma membrane,GO:0014069~postsynaptic density,GO:0015629~actin cytoskeleton,GO:0016020~membrane,GO:0030054~cell junction,GO:0030175~filopodium,GO:0043005~neuron projection,GO:0043194~axon initial segment,GO:0043197~dendritic spine,GO:0045202~synapse,GO:0045211~postsynaptic membrane, GO:0008022~protein C-terminus binding, IPR001478:PDZ domain,IPR001611:Leucine-rich repeat,IPR003591:Leucine-rich repeat, typical subtype, SM00228:PDZ,SM00369:LRR_TYP, Cell junction,Cell membrane,Complete proteome,Cytoplasm,Leucine-rich repeat,Membrane,Methylation,Phosphoprotein,Postsynaptic cell membrane,Proteomics identification,Reference proteome,Repeat,Synapse, chain:Leucine-rich repeat-containing protein 7,domain:PDZ,modified residue,repeat:LRR 1,repeat:LRR 10,repeat:LRR 11,repeat:LRR 12,repeat:LRR 13,repeat:LRR 14,repeat:LRR 15,repeat:LRR 16,repeat:LRR 17,repeat:LRR 18,repeat:LRR 2,repeat:LRR 3,repeat:LRR 4,repeat:LRR 5,repeat:LRR 6,repeat:LRR 7,repeat:LRR 8,repeat:LRR 9, Q0VAA2 leucine rich repeat containing 74A(LRRC74A) Homo sapiens IPR001611:Leucine-rich repeat, Alternative splicing,Complete proteome,Leucine-rich repeat,Reference proteome,Repeat, chain:Uncharacterized protein C14orf166B,splice variant, A0JPI9 leucine rich repeat containing 74A(Lrrc74a) Rattus norvegicus IPR001611:Leucine-rich repeat, Alternative splicing,Complete proteome,Leucine-rich repeat,Reference proteome,Repeat, chain:Uncharacterized protein C14orf166B homolog,splice variant, Q5S007 leucine rich repeat kinase 2(LRRK2) Homo sapiens GO:0000165~MAPK cascade,GO:0000186~activation of MAPKK activity,GO:0000187~activation of MAPK activity,GO:0001933~negative regulation of protein phosphorylation,GO:0001934~positive regulation of protein phosphorylation,GO:0006468~protein phosphorylation,GO:0006897~endocytosis,GO:0006914~autophagy,GO:0006979~response to oxidative stress,GO:0007005~mitochondrion organization,GO:0007030~Golgi organization,GO:0007040~lysosome organization,GO:0007264~small GTPase mediated signal transduction,GO:0007528~neuromuscular junction development,GO:0008340~determination of adult lifespan,GO:0009267~cellular response to starvation,GO:0010506~regulation of autophagy,GO:0010508~positive regulation of autophagy,GO:0010738~regulation of protein kinase A signaling,GO:0010955~negative regulation of protein processing,GO:0014041~regulation of neuron maturation,GO:0016242~negative regulation of macroautophagy,GO:0016310~phosphorylation,GO:0018105~peptidyl-serine phosphorylation,GO:0018107~peptidyl-threonine phosphorylation,GO:0019722~calcium-mediated signaling,GO:0021772~olfactory bulb development,GO:0022028~tangential migration from the subventricular zone to the olfactory bulb,GO:0031398~positive regulation of protein ubiquitination,GO:0032091~negative regulation of protein binding,GO:0032092~positive regulation of protein binding,GO:0032436~positive regulation of proteasomal ubiquitin-dependent protein catabolic process,GO:0034260~negative regulation of GTPase activity,GO:0034599~cellular response to oxidative stress,GO:0034613~cellular protein localization,GO:0035556~intracellular signal transduction,GO:0035564~regulation of kidney size,GO:0035640~exploration behavior,GO:0035641~locomotory exploration behavior,GO:0035751~regulation of lysosomal lumen pH,GO:0040012~regulation of locomotion,GO:0042391~regulation of membrane potential,GO:0043068~positive regulation of programmed cell death,GO:0043406~positive regulation of MAP kinase activity,GO:0043547~positive regulation of GTPase activity,GO:0046039~GTP metabolic process,GO:0046777~protein autophosphorylation,GO:0048312~intracellular distribution of mitochondria,GO:0048812~neuron projection morphogenesis,GO:0051646~mitochondrion localization,GO:0051900~regulation of mitochondrial depolarization,GO:0051966~regulation of synaptic transmission, glutamatergic,GO:0060070~canonical Wnt signaling pathway,GO:0060079~excitatory postsynaptic potential,GO:0060159~regulation of dopamine receptor signaling pathway,GO:0060161~positive regulation of dopamine receptor signaling pathway,GO:0060828~regulation of canonical Wnt signaling pathway,GO:0061001~regulation of dendritic spine morphogenesis,GO:0070585~protein localization to mitochondrion,GO:0070997~neuron death,GO:0071287~cellular response to manganese ion,GO:0072593~reactive oxygen species metabolic process,GO:0090140~regulation of mitochondrial fission,GO:0090263~positive regulation of canonical Wnt signaling pathway,GO:0090394~negative regulation of excitatory postsynaptic potential,GO:1901214~regulation of neuron death,GO:1901215~negative regulation of neuron death,GO:1902236~negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway,GO:1902499~positive regulation of protein autoubiquitination,GO:1902692~regulation of neuroblast proliferation,GO:1902803~regulation of synaptic vesicle transport,GO:1902823~negative regulation of late endosome to lysosome transport,GO:1902902~negative regulation of autophagosome assembly,GO:1903125~negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation,GO:1903206~negative regulation of hydrogen peroxide-induced cell death,GO:1903215~negative regulation of protein targeting to mitochondrion,GO:1903217~negative regulation of protein processing involved in protein targeting to mitochondrion,GO:1903351~cellular response to dopamine,GO:1904887~Wnt signalosome assembly,GO:1905279~regulation of retrograde transport, endosome to Golgi,GO:1905289~regulation of CAMKK-AMPK signaling cascade,GO:2000172~regulation of branching morphogenesis of a nerve,GO:2000300~regulation of synaptic vesicle exocytosis, GO:0005615~extracellular space,GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0005741~mitochondrial outer membrane,GO:0005743~mitochondrial inner membrane,GO:0005759~mitochondrial matrix,GO:0005764~lysosome,GO:0005768~endosome,GO:0005783~endoplasmic reticulum,GO:0005794~Golgi apparatus,GO:0005798~Golgi-associated vesicle,GO:0005802~trans-Golgi network,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005902~microvillus,GO:0016234~inclusion body,GO:0030054~cell junction,GO:0030424~axon,GO:0030425~dendrite,GO:0030426~growth cone,GO:0030529~intracellular ribonucleoprotein complex,GO:0030672~synaptic vesicle membrane,GO:0031410~cytoplasmic vesicle,GO:0031966~mitochondrial membrane,GO:0032473~cytoplasmic side of mitochondrial outer membrane,GO:0032839~dendrite cytoplasm,GO:0043005~neuron projection,GO:0043025~neuronal cell body,GO:0043195~terminal bouton,GO:0043204~perikaryon,GO:0044753~amphisome,GO:0044754~autolysosome,GO:0070062~extracellular exosome,GO:0097487~multivesicular body, internal vesicle,GO:0098794~postsynapse,GO:0099400~caveola neck,GO:1990909~Wnt signalosome, GO:0000149~SNARE binding,GO:0001948~glycoprotein binding,GO:0003779~actin binding,GO:0003924~GTPase activity,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0004708~MAP kinase kinase activity,GO:0005096~GTPase activator activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0005525~GTP binding,GO:0008017~microtubule binding,GO:0015631~tubulin binding,GO:0016301~kinase activity,GO:0017048~Rho GTPase binding,GO:0017075~syntaxin-1 binding,GO:0030159~receptor signaling complex scaffold activity,GO:0030276~clathrin binding,GO:0034211~GTP-dependent protein kinase activity,GO:0036479~peroxidase inhibitor activity,GO:0039706~co-receptor binding,GO:0042802~identical protein binding,GO:0042803~protein homodimerization activity,GO:0044325~ion channel binding,GO:0051018~protein kinase A binding,GO:1904713~beta-catenin destruction complex binding, IPR000719:Protein kinase, catalytic domain,IPR001611:Leucine-rich repeat,IPR003591:Leucine-rich repeat, typical subtype,IPR005225:Small GTP-binding protein domain,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR011989:Armadillo-like helical,IPR013684:Mitochondrial Rho-like,IPR015943:WD40/YVTN repeat-like-containing domain,IPR016024:Armadillo-type fold,IPR017441:Protein kinase, ATP binding site,IPR017986:WD40-repeat-containing domain,IPR020683:Ankyrin repeat-containing domain,IPR020859:ROC GTPase,IPR025875:Leucine rich repeat 4,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa05012:Parkinson's disease, 607060~Parkinson disease 8, SM00220:S_TKc,SM00369:LRR_TYP, 3D-structure,ATP-binding,Autophagy,Cell junction,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Differentiation,Disease mutation,Endoplasmic reticulum,Endosome,Golgi apparatus,GTP-binding,GTPase activation,Kinase,Leucine-rich repeat,Lysosome,Membrane,Mitochondrion,Mitochondrion inner membrane,Mitochondrion outer membrane,Neurodegeneration,Nucleotide-binding,Parkinson disease,Parkinsonism,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Serine/threonine-protein kinase,Synapse,Transferase,WD repeat, active site:Proton acceptor,binding site:ATP,chain:Leucine-rich repeat serine/threonine- protein kinase 2,compositionally biased region:Poly-Leu,domain:Protein kinase,domain:Roc,helix,nucleotide phosphate-binding region:ATP,nucleotide phosphate-binding region:GTP,repeat:LRR 1,repeat:LRR 10,repeat:LRR 11,repeat:LRR 12,repeat:LRR 13,repeat:LRR 14,repeat:LRR 15,repeat:LRR 16,repeat:LRR 2,repeat:LRR 3,repeat:LRR 4,repeat:LRR 5,repeat:LRR 6,repeat:LRR 7,repeat:LRR 8,repeat:LRR 9,sequence variant,splice variant,strand,turn, Q8N653 leucine zipper like transcription regulator 1(LZTR1) Homo sapiens GO:0006355~regulation of transcription, DNA-templated,GO:0009653~anatomical structure morphogenesis, GO:0005794~Golgi apparatus, GO:0003700~transcription factor activity, sequence-specific DNA binding, IPR000210:BTB/POZ-like,IPR006652:Kelch repeat type 1,IPR011333:BTB/POZ fold,IPR011498:Kelch repeat type 2,IPR015915:Kelch-type beta propeller, 615670~Schwannomatosis-2, susceptibility to,616564~Noonan syndrome 10, SM00225:BTB,SM00612:Kelch, Acetylation,Complete proteome,Disease mutation,Kelch repeat,Proteomics identification,Reference proteome,Repeat, chain:Leucine-zipper-like transcriptional regulator 1,domain:BTB 1,domain:BTB 2,repeat:Kelch 1,repeat:Kelch 2,repeat:Kelch 3,repeat:Kelch 4,repeat:Kelch 5,repeat:Kelch 6,sequence conflict, Q6ZMV7 leucine, glutamate and lysine rich 1(LEKR1) Homo sapiens Coiled coil,Complete proteome,Polymorphism,Reference proteome, chain:Leucine-, glutamate- and lysine-rich protein 1,compositionally biased region:Poly-Arg,sequence variant, B0W6M9 leucine-rich repeat protein SHOC-2(CpipJ_CPIJ002780) Culex quinquefasciatus IPR001611:Leucine-rich repeat,IPR003591:Leucine-rich repeat, typical subtype,IPR025875:Leucine rich repeat 4, SM00369:LRR_TYP, Complete proteome,Leucine-rich repeat,Reference proteome,Repeat, chain:Leucine-rich repeat protein soc-2 homolog,repeat:LRR 1,repeat:LRR 10,repeat:LRR 11,repeat:LRR 12,repeat:LRR 13,repeat:LRR 14,repeat:LRR 15,repeat:LRR 16,repeat:LRR 17,repeat:LRR 18,repeat:LRR 19,repeat:LRR 2,repeat:LRR 20,repeat:LRR 3,repeat:LRR 4,repeat:LRR 5,repeat:LRR 6,repeat:LRR 7,repeat:LRR 8,repeat:LRR 9, Q6P1C6 leucine-rich repeats and immunoglobulin-like domains 3(Lrig3) Mus musculus GO:0007275~multicellular organism development,GO:0032474~otolith morphogenesis, GO:0005615~extracellular space,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030659~cytoplasmic vesicle membrane,GO:0031410~cytoplasmic vesicle, IPR000483:Cysteine-rich flanking region, C-terminal,IPR001611:Leucine-rich repeat,IPR003591:Leucine-rich repeat, typical subtype,IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR007110:Immunoglobulin-like domain,IPR013098:Immunoglobulin I-set,IPR013783:Immunoglobulin-like fold, SM00082:LRRCT,SM00369:LRR_TYP,SM00408:IGc2,SM00409:IG, 3D-structure,Cell membrane,Complete proteome,Cytoplasmic vesicle,Developmental protein,Disulfide bond,Glycoprotein,Immunoglobulin domain,Leucine-rich repeat,Membrane,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Leucine-rich repeats and immunoglobulin- like domains protein 3,disulfide bond,domain:Ig-like C2-type 1,domain:Ig-like C2-type 2,domain:Ig-like C2-type 3,glycosylation site:N-linked (GlcNAc...),repeat:LRR 1,repeat:LRR 10,repeat:LRR 11,repeat:LRR 12,repeat:LRR 13,repeat:LRR 14,repeat:LRR 15,repeat:LRR 16,repeat:LRR 17,repeat:LRR 2,repeat:LRR 3,repeat:LRR 4,repeat:LRR 5,repeat:LRR 6,repeat:LRR 7,repeat:LRR 8,repeat:LRR 9,sequence conflict,signal peptide,transmembrane region, Q96BZ8 leukocyte receptor cluster member 1(LENG1) Homo sapiens GO:0005515~protein binding, IPR019339:CBF1-interacting co-repressor CIR, N-terminal domain, SM01083:SM01083, Coiled coil,Complete proteome,Phosphoprotein,Polymorphism,Reference proteome, chain:Leukocyte receptor cluster member 1,modified residue,sequence variant, Q5BIP7 lipoic acid synthetase(LIAS) Bos taurus GO:0001843~neural tube closure,GO:0006954~inflammatory response,GO:0006979~response to oxidative stress,GO:0009107~lipoate biosynthetic process,GO:0009249~protein lipoylation,GO:0032496~response to lipopolysaccharide, GO:0005739~mitochondrion, GO:0016992~lipoate synthase activity,GO:0046872~metal ion binding,GO:0051539~4 iron, 4 sulfur cluster binding, IPR003698:Lipoyl synthase,IPR006638:Elongator protein 3/MiaB/NifB,IPR007197:Radical SAM,IPR013785:Aldolase-type TIM barrel, bta00785:Lipoic acid metabolism,bta01100:Metabolic pathways, PIRSF005963:lipoyl synthase, SM00729:Elp3, 4Fe-4S,Complete proteome,Iron,Iron-sulfur,Metal-binding,Mitochondrion,Reference proteome,S-adenosyl-L-methionine,Transferase,Transit peptide, chain:Lipoyl synthase, mitochondrial,metal ion-binding site:Iron-sulfur 1 (4Fe-4S),metal ion-binding site:Iron-sulfur 2 (4Fe-4S-S-AdoMet),transit peptide:Mitochondrion, C8YR32 lipoxygenase homology domains 1(Loxhd1) Mus musculus GO:0007605~sensory perception of sound,GO:0050982~detection of mechanical stimulus, GO:0016020~membrane,GO:0032420~stereocilium,GO:0042995~cell projection, GO:0005262~calcium channel activity, IPR001024:Lipoxygenase, LH2, SM00308:LH2, Cell projection,Coiled coil,Complete proteome,Hearing,Polymorphism,Reference proteome,Repeat, A2ARV4 low density lipoprotein receptor-related protein 2(Lrp2) Mus musculus Function unknown, GO:0003281~ventricular septum development,GO:0006766~vitamin metabolic process,GO:0006897~endocytosis,GO:0006898~receptor-mediated endocytosis,GO:0007507~heart development,GO:0008283~cell proliferation,GO:0010165~response to X-ray,GO:0016197~endosomal transport,GO:0020028~hemoglobin import,GO:0030900~forebrain development,GO:0035904~aorta development,GO:0042953~lipoprotein transport,GO:0045056~transcytosis,GO:0046879~hormone secretion,GO:0060976~coronary vasculature development, GO:0005615~extracellular space,GO:0005737~cytoplasm,GO:0005765~lysosomal membrane,GO:0005768~endosome,GO:0005783~endoplasmic reticulum,GO:0005794~Golgi apparatus,GO:0005903~brush border,GO:0005905~clathrin-coated pit,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0016324~apical plasma membrane,GO:0030139~endocytic vesicle,GO:0031526~brush border membrane,GO:0043234~protein complex,GO:0043235~receptor complex,GO:0045121~membrane raft,GO:0045177~apical part of cell,GO:0070062~extracellular exosome, GO:0004872~receptor activity,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0017124~SH3 domain binding,GO:0030165~PDZ domain binding,GO:0030492~hemoglobin binding,GO:0032403~protein complex binding,GO:0042562~hormone binding,GO:0042954~lipoprotein transporter activity,GO:0046872~metal ion binding,GO:0050750~low-density lipoprotein particle receptor binding, IPR000033:LDLR class B repeat,IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR001881:EGF-like calcium-binding,IPR002172:Low-density lipoprotein (LDL) receptor class A repeat,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR011042:Six-bladed beta-propeller, TolB-like,IPR013032:EGF-like, conserved site,IPR018097:EGF-like calcium-binding, conserved site,IPR023415:Low-density lipoprotein (LDL) receptor class A, conserved site,IPR026823:Complement Clr-like EGF domain, mmu04340:Hedgehog signaling pathway,mmu04918:Thyroid hormone synthesis, SM00135:LY,SM00179:EGF_CA,SM00181:EGF,SM00192:LDLa, Calcium,Coated pit,Complete proteome,Disulfide bond,EGF-like domain,Endocytosis,Glycoprotein,Membrane,Metal-binding,Phosphoprotein,Proteomics identification,Receptor,Reference proteome,Repeat,SH3-binding,Signal,Transmembrane,Transmembrane helix, chain:Low-density lipoprotein receptor-related protein 2,disulfide bond,domain:EGF-like 1,domain:EGF-like 10,domain:EGF-like 11,domain:EGF-like 12; calcium-binding,domain:EGF-like 13,domain:EGF-like 14,domain:EGF-like 15; calcium-binding,domain:EGF-like 16,domain:EGF-like 17,domain:EGF-like 2,domain:EGF-like 3,domain:EGF-like 4,domain:EGF-like 5,domain:EGF-like 6; calcium-binding,domain:EGF-like 7,domain:EGF-like 8,domain:EGF-like 9,domain:LDL-receptor class A 1,domain:LDL-receptor class A 10,domain:LDL-receptor class A 11,domain:LDL-receptor class A 12,domain:LDL-receptor class A 13,domain:LDL-receptor class A 14,domain:LDL-receptor class A 15,domain:LDL-receptor class A 16,domain:LDL-receptor class A 17,domain:LDL-receptor class A 18,domain:LDL-receptor class A 19,domain:LDL-receptor class A 2,domain:LDL-receptor class A 20,domain:LDL-receptor class A 21,domain:LDL-receptor class A 22,domain:LDL-receptor class A 23,domain:LDL-receptor class A 24,domain:LDL-receptor class A 25,domain:LDL-receptor class A 26,domain:LDL-receptor class A 27,domain:LDL-receptor class A 28,domain:LDL-receptor class A 29,domain:LDL-receptor class A 3,domain:LDL-receptor class A 30,domain:LDL-receptor class A 31,domain:LDL-receptor class A 32,domain:LDL-receptor class A 33,domain:LDL-receptor class A 34,domain:LDL-receptor class A 35,domain:LDL-receptor class A 36,domain:LDL-receptor class A 4,domain:LDL-receptor class A 5,domain:LDL-receptor class A 6,domain:LDL-receptor class A 7,domain:LDL-receptor class A 8,domain:LDL-receptor class A 9,glycosylation site:N-linked (GlcNAc...),modified residue,repeat:LDL-receptor class B 1,repeat:LDL-receptor class B 10,repeat:LDL-receptor class B 11,repeat:LDL-receptor class B 12,repeat:LDL-receptor class B 13,repeat:LDL-receptor class B 14,repeat:LDL-receptor class B 15,repeat:LDL-receptor class B 16,repeat:LDL-receptor class B 17,repeat:LDL-receptor class B 18,repeat:LDL-receptor class B 19,repeat:LDL-receptor class B 2,repeat:LDL-receptor class B 20,repeat:LDL-receptor class B 21,repeat:LDL-receptor class B 22,repeat:LDL-receptor class B 23,repeat:LDL-receptor class B 24,repeat:LDL-receptor class B 25,repeat:LDL-receptor class B 26,repeat:LDL-receptor class B 27,repeat:LDL-receptor class B 28,repeat:LDL-receptor class B 29,repeat:LDL-receptor class B 3,repeat:LDL-receptor class B 30,repeat:LDL-receptor class B 31,repeat:LDL-receptor class B 32,repeat:LDL-receptor class B 33,repeat:LDL-receptor class B 34,repeat:LDL-receptor class B 35,repeat:LDL-receptor class B 36,repeat:LDL-receptor class B 37,repeat:LDL-receptor class B 4,repeat:LDL-receptor class B 5,repeat:LDL-receptor class B 6,repeat:LDL-receptor class B 7,repeat:LDL-receptor class B 8,repeat:LDL-receptor class B 9,sequence conflict,short sequence motif:Cell attachment site,short sequence motif:Endocytosis signal,short sequence motif:SH2-binding,short sequence motif:SH3-binding,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, O08550 lysine (K)-specific methyltransferase 2B(Kmt2b) Mus musculus General function prediction only, GO:0001541~ovarian follicle development,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007613~memory,GO:0009994~oocyte differentiation,GO:0016458~gene silencing,GO:0016569~covalent chromatin modification,GO:0030728~ovulation,GO:0032259~methylation,GO:0034968~histone lysine methylation,GO:0051568~histone H3-K4 methylation,GO:0051569~regulation of histone H3-K4 methylation,GO:0080182~histone H3-K4 trimethylation, GO:0005634~nucleus,GO:0035097~histone methyltransferase complex, GO:0003677~DNA binding,GO:0008168~methyltransferase activity,GO:0008270~zinc ion binding,GO:0016740~transferase activity,GO:0018024~histone-lysine N-methyltransferase activity,GO:0042800~histone methyltransferase activity (H3-K4 specific),GO:0046872~metal ion binding, IPR001214:SET domain,IPR001965:Zinc finger, PHD-type,IPR002857:Zinc finger, CXXC-type,IPR003616:Post-SET domain,IPR003888:FY-rich, N-terminal,IPR003889:FY-rich, C-terminal,IPR011011:Zinc finger, FYVE/PHD-type,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR019787:Zinc finger, PHD-finger, mmu00310:Lysine degradation, SM00249:PHD,SM00317:SET,SM00508:PostSET,SM00541:FYRN,SM00542:FYRC, Acetylation,Chromatin regulator,Coiled coil,Complete proteome,DNA-binding,Metal-binding,Methyltransferase,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,S-adenosyl-L-methionine,Transcription,Transcription regulation,Transferase,Zinc,Zinc-finger, binding site:S-adenosyl-L-methionine,chain:Histone-lysine N-methyltransferase MLL4,compositionally biased region:Glu-rich,compositionally biased region:Gly-rich,compositionally biased region:Pro-rich,DNA-binding region:A.T hook 1,DNA-binding region:A.T hook 2,DNA-binding region:A.T hook 3,domain:Post-SET,domain:SET,metal ion-binding site:Zinc,modified residue,region of interest:S-adenosyl-L-methionine binding,zinc finger region:CXXC-type,zinc finger region:PHD-type 1,zinc finger region:PHD-type 2,zinc finger region:PHD-type 3, Q8WYB5 lysine acetyltransferase 6B(KAT6B) Homo sapiens GO:0006334~nucleosome assembly,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0016573~histone acetylation,GO:0043966~histone H3 acetylation,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter, GO:0000786~nucleosome,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0070776~MOZ/MORF histone acetyltransferase complex, GO:0003677~DNA binding,GO:0004402~histone acetyltransferase activity,GO:0005515~protein binding,GO:0008134~transcription factor binding,GO:0008270~zinc ion binding,GO:0016407~acetyltransferase activity,GO:0032403~protein complex binding, IPR001965:Zinc finger, PHD-type,IPR002717:MOZ/SAS-like protein,IPR005818:Histone H1/H5,IPR011011:Zinc finger, FYVE/PHD-type,IPR011991:Winged helix-turn-helix DNA-binding domain,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR016181:Acyl-CoA N-acyltransferase,IPR019787:Zinc finger, PHD-finger, 603736~SBBYSS syndrome,606170~Genitopatellar syndrome, SM00249:PHD,SM00526:H15, Acetylation,Activator,Acyltransferase,Alternative splicing,Chromatin regulator,Chromosomal rearrangement,Coiled coil,Complete proteome,Isopeptide bond,Metal-binding,Nucleus,Phosphoprotein,Polymorphism,Reference proteome,Repeat,Repressor,Transcription,Transcription regulation,Transferase,Ubl conjugation,Zinc,Zinc-finger, chain:Histone acetyltransferase MYST4,compositionally biased region:Met-rich,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Ser,compositionally biased region:Ser-rich,modified residue,region of interest:Catalytic,region of interest:Interaction with BRPF1,region of interest:Interaction with RUNX1 and RUNX2,region of interest:Negatively regulates HAT activity,sequence conflict,sequence variant,site:Breakpoint for translocation to form MYST4-CREBBP,splice variant,zinc finger region:C2HC-type,zinc finger region:PHD-type 1,zinc finger region:PHD-type 2, P29375 lysine demethylase 5A(KDM5A) Homo sapiens GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0006366~transcription from RNA polymerase II promoter,GO:0007283~spermatogenesis,GO:0008584~male gonad development,GO:0032922~circadian regulation of gene expression,GO:0034720~histone H3-K4 demethylation,GO:0045893~positive regulation of transcription, DNA-templated,GO:0055114~oxidation-reduction process,GO:1901726~negative regulation of histone deacetylase activity, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0019907~cyclin-dependent protein kinase activating kinase holoenzyme complex,GO:0032993~protein-DNA complex, GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0003713~transcription coactivator activity,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0016706~oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors,GO:0031490~chromatin DNA binding,GO:0032452~histone demethylase activity, IPR001606:ARID/BRIGHT DNA-binding domain,IPR001965:Zinc finger, PHD-type,IPR003347:JmjC domain,IPR003349:Transcription factor jumonji, JmjN,IPR004198:Zinc finger, C5HC2-type,IPR011011:Zinc finger, FYVE/PHD-type,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR013637:Lysine-specific demethylase-like domain,IPR019786:Zinc finger, PHD-type, conserved site,IPR019787:Zinc finger, PHD-finger, SM00249:PHD,SM00501:BRIGHT,SM00545:JmjN,SM00558:JmjC, 3D-structure,Activator,Alternative splicing,Biological rhythms,Chromatin regulator,Complete proteome,Developmental protein,Dioxygenase,Iron,Metal-binding,Nucleus,Oxidoreductase,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Lysine-specific demethylase 5A,compositionally biased region:Lys-rich,domain:ARID,domain:JmjC,domain:JmjN,helix,modified residue,region of interest:Interaction with LMO2,sequence conflict,sequence variant,splice variant,strand,turn,zinc finger region:PHD-type 1,zinc finger region:PHD-type 2,zinc finger region:PHD-type 3, Q921Y4 major facilitator superfamily domain containing 5(Mfsd5) Mus musculus GO:0006810~transport,GO:0006811~ion transport,GO:0015689~molybdate ion transport, GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0015098~molybdate ion transmembrane transporter activity, IPR008509:Protein of unknown function DUF791,IPR020846:Major facilitator superfamily domain, Cell membrane,Complete proteome,Ion transport,Membrane,Reference proteome,Transmembrane,Transmembrane helix,Transport, chain:Major facilitator superfamily domain- containing protein 5,transmembrane region, Q5ZME2 malate dehydrogenase 1(MDH1) Gallus gallus GO:0002230~positive regulation of defense response to virus by host,GO:0005975~carbohydrate metabolic process,GO:0006099~tricarboxylic acid cycle,GO:0006107~oxaloacetate metabolic process,GO:0006108~malate metabolic process,GO:0006734~NADH metabolic process,GO:0098779~mitophagy in response to mitochondrial depolarization,GO:0098792~xenophagy, GO:0005615~extracellular space,GO:0005739~mitochondrion,GO:0005813~centrosome,GO:0005829~cytosol,GO:0043209~myelin sheath,GO:0070062~extracellular exosome, GO:0030060~L-malate dehydrogenase activity, IPR001236:Lactate/malate dehydrogenase, N-terminal,IPR001252:Malate dehydrogenase, active site,IPR001557:L-lactate/malate dehydrogenase,IPR010945:Malate dehydrogenase, type 2,IPR011274:Malate dehydrogenase, NAD-dependent, cytosolic,IPR015955:Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal,IPR016040:NAD(P)-binding domain,IPR022383:Lactate/malate dehydrogenase, C-terminal, gga00020:Citrate cycle (TCA cycle),gga00270:Cysteine and methionine metabolism,gga00620:Pyruvate metabolism,gga00630:Glyoxylate and dicarboxylate metabolism,gga01100:Metabolic pathways,gga01130:Biosynthesis of antibiotics,gga01200:Carbon metabolism, PIRSF000102:L-lactate/malate dehydrogenase, Complete proteome,Cytoplasm,NAD,Oxidoreductase,Reference proteome,Tricarboxylic acid cycle, active site:Proton acceptor,binding site:NAD,binding site:Substrate,chain:Malate dehydrogenase, cytoplasmic,nucleotide phosphate-binding region:NAD, A4IIK1 malignant fibrous histiocytoma amplified sequence 1(mfhas1) Xenopus tropicalis GO:0007264~small GTPase mediated signal transduction, GO:0005622~intracellular, GO:0005525~GTP binding, IPR001611:Leucine-rich repeat,IPR003591:Leucine-rich repeat, typical subtype,IPR013684:Mitochondrial Rho-like,IPR020859:ROC GTPase,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00369:LRR_TYP, Complete proteome,Leucine-rich repeat,Reference proteome,Repeat, chain:Malignant fibrous histiocytoma-amplified sequence 1 homolog,domain:Roc,repeat:LRR 1,repeat:LRR 10,repeat:LRR 11,repeat:LRR 12,repeat:LRR 13,repeat:LRR 14,repeat:LRR 15,repeat:LRR 2,repeat:LRR 3,repeat:LRR 4,repeat:LRR 5,repeat:LRR 6,repeat:LRR 7,repeat:LRR 8,repeat:LRR 9, Q61830 mannose receptor, C type 1(Mrc1) Mus musculus GO:0006897~endocytosis,GO:0006898~receptor-mediated endocytosis,GO:0071222~cellular response to lipopolysaccharide,GO:0071346~cellular response to interferon-gamma,GO:0071353~cellular response to interleukin-4, GO:0005768~endosome,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0009986~cell surface,GO:0010008~endosome membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0004872~receptor activity,GO:0004888~transmembrane signaling receptor activity,GO:0005537~mannose binding,GO:0030246~carbohydrate binding, IPR000562:Fibronectin, type II, collagen-binding,IPR000772:Ricin B lectin domain,IPR001304:C-type lectin,IPR013806:Kringle-like fold,IPR016186:C-type lectin-like,IPR016187:C-type lectin fold,IPR018378:C-type lectin, conserved site, mmu04145:Phagosome,mmu05152:Tuberculosis, SM00034:CLECT,SM00059:FN2,SM00458:RICIN, 3D-structure,Calcium,Cell membrane,Complete proteome,Disulfide bond,Endocytosis,Endosome,Glycoprotein,Lectin,Membrane,Receptor,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Macrophage mannose receptor 1,disulfide bond,domain:C-type lectin 1,domain:C-type lectin 2,domain:C-type lectin 3,domain:C-type lectin 4,domain:C-type lectin 5,domain:C-type lectin 6,domain:C-type lectin 7,domain:C-type lectin 8,domain:Fibronectin type-II,domain:Ricin B-type lectin,glycosylation site:N-linked (GlcNAc...),helix,modified residue,signal peptide,strand,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region,turn, Q8BRK9 mannosidase 2, alpha 2(Man2a2) Mus musculus GO:0005975~carbohydrate metabolic process,GO:0006013~mannose metabolic process,GO:0006491~N-glycan processing,GO:0006517~protein deglycosylation,GO:0008152~metabolic process, GO:0000139~Golgi membrane,GO:0005794~Golgi apparatus,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0003824~catalytic activity,GO:0004553~hydrolase activity, hydrolyzing O-glycosyl compounds,GO:0004559~alpha-mannosidase activity,GO:0004572~mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity,GO:0008270~zinc ion binding,GO:0015923~mannosidase activity,GO:0016787~hydrolase activity,GO:0016798~hydrolase activity, acting on glycosyl bonds,GO:0016799~hydrolase activity, hydrolyzing N-glycosyl compounds,GO:0030246~carbohydrate binding,GO:0046872~metal ion binding, IPR000602:Glycoside hydrolase family 38, N-terminal domain,IPR011013:Galactose mutarotase-like domain,IPR011330:Glycoside hydrolase/deacetylase, beta/alpha-barrel,IPR011682:Glycosyl hydrolase family 38, C-terminal,IPR013780:Glycosyl hydrolase, family 13, all-beta,IPR015341:Glycoside hydrolase, family 38, central domain,IPR027291:Glycoside hydrolase 38/57, N-terminal domain, mmu00510:N-Glycan biosynthesis,mmu01100:Metabolic pathways, SM00872:SM00872, Alternative splicing,Coiled coil,Complete proteome,Disulfide bond,Glycoprotein,Glycosidase,Golgi apparatus,Hydrolase,Membrane,Metal-binding,Proteomics identification,Reference proteome,Signal-anchor,Transmembrane,Transmembrane helix,Zinc, Q91821 maternal embryonic leucine zipper kinase L homeolog(melk.L) Xenopus laevis GO:0006915~apoptotic process,GO:0007049~cell cycle,GO:0008283~cell proliferation,GO:0030097~hemopoiesis,GO:0043065~positive regulation of apoptotic process,GO:0046777~protein autophosphorylation,GO:0061351~neural precursor cell proliferation, GO:0005886~plasma membrane,GO:0005938~cell cortex, GO:0004674~protein serine/threonine kinase activity,GO:0004715~non-membrane spanning protein tyrosine kinase activity,GO:0005509~calcium ion binding,GO:0005524~ATP binding,GO:0008289~lipid binding, IPR000719:Protein kinase, catalytic domain,IPR001772:Kinase associated domain 1 (KA1),IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, SM00220:S_TKc, Apoptosis,ATP-binding,Cell cycle,Cell membrane,Kinase,Lipid-binding,Membrane,Nucleotide-binding,Phosphoprotein,Serine/threonine-protein kinase,Transferase, P42346 mechanistic target of rapamycin(Mtor) Rattus norvegicus GO:0001932~regulation of protein phosphorylation,GO:0001933~negative regulation of protein phosphorylation,GO:0001934~positive regulation of protein phosphorylation,GO:0001938~positive regulation of endothelial cell proliferation,GO:0003007~heart morphogenesis,GO:0003179~heart valve morphogenesis,GO:0005979~regulation of glycogen biosynthetic process,GO:0006109~regulation of carbohydrate metabolic process,GO:0006112~energy reserve metabolic process,GO:0006207~'de novo' pyrimidine nucleobase biosynthetic process,GO:0006281~DNA repair,GO:0006468~protein phosphorylation,GO:0007281~germ cell development,GO:0007420~brain development,GO:0007569~cell aging,GO:0007616~long-term memory,GO:0008542~visual learning,GO:0009791~post-embryonic development,GO:0010507~negative regulation of autophagy,GO:0010592~positive regulation of lamellipodium assembly,GO:0010628~positive regulation of gene expression,GO:0010831~positive regulation of myotube differentiation,GO:0010942~positive regulation of cell death,GO:0010976~positive regulation of neuron projection development,GO:0014042~positive regulation of neuron maturation,GO:0014736~negative regulation of muscle atrophy,GO:0016049~cell growth,GO:0016242~negative regulation of macroautophagy,GO:0016310~phosphorylation,GO:0018105~peptidyl-serine phosphorylation,GO:0018107~peptidyl-threonine phosphorylation,GO:0021510~spinal cord development,GO:0030030~cell projection organization,GO:0030838~positive regulation of actin filament polymerization,GO:0031397~negative regulation of protein ubiquitination,GO:0031529~ruffle organization,GO:0031641~regulation of myelination,GO:0031669~cellular response to nutrient levels,GO:0031929~TOR signaling,GO:0031998~regulation of fatty acid beta-oxidation,GO:0032095~regulation of response to food,GO:0032868~response to insulin,GO:0032956~regulation of actin cytoskeleton organization,GO:0035176~social behavior,GO:0035264~multicellular organism growth,GO:0042060~wound healing,GO:0042220~response to cocaine,GO:0043087~regulation of GTPase activity,GO:0043200~response to amino acid,GO:0043278~response to morphine,GO:0043610~regulation of carbohydrate utilization,GO:0045429~positive regulation of nitric oxide biosynthetic process,GO:0045670~regulation of osteoclast differentiation,GO:0045727~positive regulation of translation,GO:0045792~negative regulation of cell size,GO:0045859~regulation of protein kinase activity,GO:0045945~positive regulation of transcription from RNA polymerase III promoter,GO:0046777~protein autophosphorylation,GO:0046889~positive regulation of lipid biosynthetic process,GO:0048255~mRNA stabilization,GO:0048661~positive regulation of smooth muscle cell proliferation,GO:0048714~positive regulation of oligodendrocyte differentiation,GO:0048738~cardiac muscle tissue development,GO:0050731~positive regulation of peptidyl-tyrosine phosphorylation,GO:0050769~positive regulation of neurogenesis,GO:0050882~voluntary musculoskeletal movement,GO:0051496~positive regulation of stress fiber assembly,GO:0051534~negative regulation of NFAT protein import into nucleus,GO:0051896~regulation of protein kinase B signaling,GO:0051897~positive regulation of protein kinase B signaling,GO:0055006~cardiac cell development,GO:0055013~cardiac muscle cell development,GO:0060048~cardiac muscle contraction,GO:0060135~maternal process involved in female pregnancy,GO:0060252~positive regulation of glial cell proliferation,GO:0060999~positive regulation of dendritic spine development,GO:0061051~positive regulation of cell growth involved in cardiac muscle cell development,GO:0071456~cellular response to hypoxia,GO:0090335~regulation of brown fat cell differentiation,GO:0090559~regulation of membrane permeability,GO:1901216~positive regulation of neuron death,GO:1901838~positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter,GO:1904000~positive regulation of eating behavior,GO:1904056~positive regulation of cholangiocyte proliferation,GO:1904058~positive regulation of sensory perception of pain,GO:1904193~negative regulation of cholangiocyte apoptotic process,GO:1904197~positive regulation of granulosa cell proliferation,GO:1904206~positive regulation of skeletal muscle hypertrophy,GO:1904213~negative regulation of iodide transmembrane transport, GO:0000139~Golgi membrane,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005741~mitochondrial outer membrane,GO:0005764~lysosome,GO:0005765~lysosomal membrane,GO:0005789~endoplasmic reticulum membrane,GO:0005829~cytosol,GO:0012505~endomembrane system,GO:0016020~membrane,GO:0016605~PML body,GO:0030425~dendrite,GO:0031931~TORC1 complex,GO:0031932~TORC2 complex,GO:0032991~macromolecular complex,GO:0043025~neuronal cell body, GO:0001030~RNA polymerase III type 1 promoter DNA binding,GO:0001031~RNA polymerase III type 2 promoter DNA binding,GO:0001032~RNA polymerase III type 3 promoter DNA binding,GO:0001156~TFIIIC-class transcription factor binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0019901~protein kinase binding,GO:0019904~protein domain specific binding,GO:0043022~ribosome binding,GO:0044877~macromolecular complex binding,GO:0051219~phosphoprotein binding, IPR000403:Phosphatidylinositol 3-/4-kinase, catalytic domain,IPR003151:PIK-related kinase, FAT,IPR003152:PIK-related kinase, FATC,IPR009076:Rapamycin-binding domain,IPR011009:Protein kinase-like domain,IPR011989:Armadillo-like helical,IPR011990:Tetratricopeptide-like helical,IPR014009:PIK-related kinase,IPR016024:Armadillo-type fold,IPR018936:Phosphatidylinositol 3/4-kinase, conserved site,IPR024585:Domain of unknown function DUF3385, target of rapamycin protein,IPR026683:Serine/threonine-protein kinase TOR/Smg1, rno04012:ErbB signaling pathway,rno04066:HIF-1 signaling pathway,rno04150:mTOR signaling pathway,rno04151:PI3K-Akt signaling pathway,rno04152:AMPK signaling pathway,rno04910:Insulin signaling pathway,rno04919:Thyroid hormone signaling pathway,rno04920:Adipocytokine signaling pathway,rno04930:Type II diabetes mellitus,rno04931:Insulin resistance,rno05200:Pathways in cancer,rno05205:Proteoglycans in cancer,rno05206:MicroRNAs in cancer,rno05214:Glioma,rno05215:Prostate cancer,rno05221:Acute myeloid leukemia,rno05230:Central carbon metabolism in cancer,rno05231:Choline metabolism in cancer, SM00146:PI3Kc,SM01343:SM01343,SM01346:SM01346, Acetylation,ATP-binding,Complete proteome,Cytoplasm,Direct protein sequencing,Endoplasmic reticulum,Golgi apparatus,Kinase,Lysosome,Membrane,Mitochondrion,Mitochondrion outer membrane,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Serine/threonine-protein kinase,TPR repeat,Transferase, chain:Serine/threonine-protein kinase mTOR,domain:FAT,domain:FATC,domain:PI3K/PI4K,modified residue,repeat:HEAT 1,repeat:HEAT 2,repeat:HEAT 3,repeat:HEAT 4,repeat:HEAT 5,repeat:HEAT 6,repeat:HEAT 7, Q8BQM9 mediator complex subunit 12-like(Med12l) Mus musculus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter, GO:0005634~nucleus,GO:0016592~mediator complex, GO:0001104~RNA polymerase II transcription cofactor activity,GO:0001105~RNA polymerase II transcription coactivator activity,GO:0008013~beta-catenin binding,GO:0008134~transcription factor binding, IPR019035:Mediator complex, subunit Med12,IPR021989:Mediator complex, subunit Med12, catenin-binding,IPR021990:Mediator complex, subunit Med12, LCEWAV-domain, mmu04919:Thyroid hormone signaling pathway, SM01281:SM01281, Activator,Alternative splicing,Coiled coil,Complete proteome,Direct protein sequencing,Nucleus,Phosphoprotein,Reference proteome,Repressor,Transcription,Transcription regulation, chain:Mediator of RNA polymerase II transcription subunit 12-like protein,compositionally biased region:Gln-rich,modified residue,splice variant, O60244 mediator complex subunit 14(MED14) Homo sapiens GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0006367~transcription initiation from RNA polymerase II promoter,GO:0019827~stem cell population maintenance,GO:0030518~intracellular steroid hormone receptor signaling pathway,GO:0030521~androgen receptor signaling pathway,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0016020~membrane,GO:0016592~mediator complex,GO:0070847~core mediator complex, GO:0001104~RNA polymerase II transcription cofactor activity,GO:0003712~transcription cofactor activity,GO:0003713~transcription coactivator activity,GO:0004872~receptor activity,GO:0005515~protein binding,GO:0030374~ligand-dependent nuclear receptor transcription coactivator activity,GO:0042809~vitamin D receptor binding, IPR013947:Mediator complex, subunit Med14, hsa04919:Thyroid hormone signaling pathway, Activator,Complete proteome,Direct protein sequencing,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation, chain:Mediator of RNA polymerase II transcription subunit 14,compositionally biased region:Pro-rich,modified residue,region of interest:Interaction with SREBF1,region of interest:Interaction with STAT2,sequence conflict,sequence variant,short sequence motif:LXXLL motif 1,short sequence motif:LXXLL motif 2, Q6NS15 mediator complex subunit 15 L homeolog(med15.L) Xenopus laevis GO:0006351~transcription, DNA-templated, GO:0005737~cytoplasm,GO:0016592~mediator complex, GO:0001104~RNA polymerase II transcription cofactor activity, IPR019087:Mediator complex, subunit Med15, metazoa, Activator,Alternative splicing,Cytoplasm,Nucleus,Transcription,Transcription regulation, chain:Mediator of RNA polymerase II transcription subunit 15,compositionally biased region:Gln-rich,compositionally biased region:Poly-Pro,compositionally biased region:Pro-rich,sequence conflict,splice variant, Q9BUE0 mediator complex subunit 18(MED18) Homo sapiens GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0006369~termination of RNA polymerase II transcription,GO:0016567~protein ubiquitination, GO:0000151~ubiquitin ligase complex,GO:0016592~mediator complex,GO:0070847~core mediator complex, GO:0001104~RNA polymerase II transcription cofactor activity,GO:0005515~protein binding,GO:0061630~ubiquitin protein ligase activity, IPR019095:Mediator complex, subunit Med18, metazoa/fungi, Activator,Complete proteome,Nucleus,Phosphoprotein,Reference proteome,Transcription,Transcription regulation, chain:Mediator of RNA polymerase II transcription subunit 18,modified residue,sequence conflict, A5WUL3 mediator complex subunit 22(med22) Danio rerio GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter, GO:0005634~nucleus,GO:0016592~mediator complex, GO:0001104~RNA polymerase II transcription cofactor activity, IPR009332:Mediator complex, subunit Med22, Activator,Alternative splicing,Complete proteome,Nucleus,Proteomics identification,Reference proteome,Transcription,Transcription regulation, chain:Mediator of RNA polymerase II transcription subunit 22,splice variant, Q6RHR9 membrane associated guanylate kinase, WW and PDZ domain containing 1(Magi1) Mus musculus GO:0070997~neuron death, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0005912~adherens junction,GO:0005923~bicellular tight junction,GO:0016020~membrane,GO:0030054~cell junction,GO:0042995~cell projection, GO:0000166~nucleotide binding,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0032947~protein complex scaffold,GO:0051393~alpha-actinin binding, IPR001202:WW domain,IPR001478:PDZ domain,IPR008144:Guanylate kinase,IPR008145:Guanylate kinase/L-type calcium channel,IPR020590:Guanylate kinase, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, mmu04015:Rap1 signaling pathway,mmu04530:Tight junction, SM00072:GuKc,SM00228:PDZ,SM00456:WW, 3D-structure,Alternative splicing,ATP-binding,Cell junction,Cell membrane,Complete proteome,Cytoplasm,Membrane,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Tight junction, chain:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1,compositionally biased region:Poly-Arg,compositionally biased region:Poly-Gln,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Gly,domain:Guanylate kinase-like,domain:PDZ 1,domain:PDZ 2,domain:PDZ 3,domain:PDZ 4,domain:PDZ 5,domain:PDZ 6,domain:WW 1,domain:WW 2,helix,modified residue,nucleotide phosphate-binding region:ATP,region of interest:Interaction with FCHSD2,sequence conflict,splice variant,strand, O88382 membrane associated guanylate kinase, WW and PDZ domain containing 2(Magi2) Rattus norvegicus GO:0002092~positive regulation of receptor internalization,GO:0003094~glomerular filtration,GO:0007165~signal transduction,GO:0008285~negative regulation of cell proliferation,GO:0010976~positive regulation of neuron projection development,GO:0030336~negative regulation of cell migration,GO:0032516~positive regulation of phosphoprotein phosphatase activity,GO:0032926~negative regulation of activin receptor signaling pathway,GO:0038180~nerve growth factor signaling pathway,GO:0043113~receptor clustering,GO:0051291~protein heterooligomerization,GO:0051898~negative regulation of protein kinase B signaling,GO:0060395~SMAD protein signal transduction,GO:0071850~mitotic cell cycle arrest,GO:0072015~glomerular visceral epithelial cell development,GO:0097118~neuroligin clustering involved in postsynaptic membrane assembly,GO:1990090~cellular response to nerve growth factor stimulus,GO:2000809~positive regulation of synaptic vesicle clustering, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005770~late endosome,GO:0005886~plasma membrane,GO:0005923~bicellular tight junction,GO:0014069~postsynaptic density,GO:0030425~dendrite,GO:0036057~slit diaphragm,GO:0043234~protein complex,GO:0045202~synapse,GO:0048471~perinuclear region of cytoplasm, GO:0004871~signal transducer activity,GO:0005515~protein binding,GO:0019902~phosphatase binding,GO:0030159~receptor signaling complex scaffold activity,GO:0031697~beta-1 adrenergic receptor binding,GO:0032403~protein complex binding,GO:0032947~protein complex scaffold,GO:0046332~SMAD binding,GO:0070699~type II activin receptor binding, IPR001202:WW domain,IPR001478:PDZ domain,IPR008144:Guanylate kinase,IPR008145:Guanylate kinase/L-type calcium channel,IPR020590:Guanylate kinase, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, rno04015:Rap1 signaling pathway, SM00072:GuKc,SM00228:PDZ,SM00456:WW, Alternative splicing,Cell junction,Cell membrane,Complete proteome,Cytoplasm,Endosome,Membrane,Neurogenesis,Phosphoprotein,Reference proteome,Repeat,Synapse,Synaptosome, chain:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2,domain:Guanylate kinase-like,domain:PDZ,domain:PDZ 1,domain:PDZ 2,domain:PDZ 3,domain:PDZ 4,domain:PDZ 5,domain:WW 1,domain:WW 2,modified residue,region of interest:Interaction with DDN,sequence conflict,splice variant, O15442 metallophosphoesterase domain containing 1(MPPED1) Homo sapiens GO:0016787~hydrolase activity, IPR004843:Metallophosphoesterase domain,IPR024201:Calcineurin-like phosphoesterase, PIRSF035808:phosphoesterase, brain protein 239 type, Alternative splicing,Complete proteome,Hydrolase,Reference proteome, chain:Metallophosphoesterase domain-containing protein 1, B1WBP0 metallophosphoesterase domain containing 2(Mpped2) Rattus norvegicus General function prediction only, GO:0016787~hydrolase activity,GO:0046872~metal ion binding, IPR004843:Metallophosphoesterase domain,IPR024201:Calcineurin-like phosphoesterase, PIRSF035808:phosphoesterase, brain protein 239 type, 3D-structure,Cobalt,Complete proteome,Hydrolase,Manganese,Metal-binding,Reference proteome, chain:Metallophosphoesterase MPPED2,mutagenesis site,sequence conflict, Q8K1A0 methyltransferase like 5(Mettl5) Mus musculus Translation, ribosomal structure and biogenesis, GO:0032259~methylation, GO:0003676~nucleic acid binding,GO:0008168~methyltransferase activity,GO:0016740~transferase activity, IPR002052:DNA methylase, N-6 adenine-specific, conserved site,IPR007848:Methyltransferase small domain, Complete proteome,Methyltransferase,Proteomics identification,Reference proteome,Transferase, chain:Methyltransferase-like protein 5, Q5JR59 microtubule associated tumor suppressor candidate 2(MTUS2) Homo sapiens GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005874~microtubule,GO:0005881~cytoplasmic microtubule, GO:0005515~protein binding,GO:0008017~microtubule binding,GO:0042803~protein homodimerization activity, Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Microtubule,Polymorphism,Reference proteome, chain:Microtubule-associated tumor suppressor candidate 2,region of interest:Localization to the growing distal tip of microtubules,region of interest:Mediates interaction with MAPRE1,region of interest:Sufficient for interaction with KIF2C,sequence conflict,sequence variant,splice variant, Q9UPN3 microtubule-actin crosslinking factor 1(MACF1) Homo sapiens GO:0007010~cytoskeleton organization,GO:0010632~regulation of epithelial cell migration,GO:0016055~Wnt signaling pathway,GO:0030177~positive regulation of Wnt signaling pathway,GO:0032886~regulation of microtubule-based process,GO:0042060~wound healing,GO:0043001~Golgi to plasma membrane protein transport,GO:0045773~positive regulation of axon extension,GO:0051893~regulation of focal adhesion assembly,GO:0098609~cell-cell adhesion, GO:0005737~cytoplasm,GO:0005794~Golgi apparatus,GO:0005856~cytoskeleton,GO:0005874~microtubule,GO:0005886~plasma membrane,GO:0005913~cell-cell adherens junction,GO:0016021~integral component of membrane,GO:0032587~ruffle membrane, GO:0003779~actin binding,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0008017~microtubule binding,GO:0016887~ATPase activity,GO:0044822~poly(A) RNA binding,GO:0051015~actin filament binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR001101:Plectin repeat,IPR001589:Actinin-type, actin-binding, conserved site,IPR001715:Calponin homology domain,IPR002017:Spectrin repeat,IPR002048:EF-hand domain,IPR003108:Growth-arrest-specific protein 2 domain,IPR011992:EF-hand-like domain,IPR018159:Spectrin/alpha-actinin,IPR018247:EF-Hand 1, calcium-binding site, SM00033:CH,SM00054:EFh,SM00150:SPEC,SM00243:GAS2,SM00250:PLEC, 3D-structure,Acetylation,Actin-binding,Alternative splicing,Calcium,Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Golgi apparatus,Leucine-rich repeat,Membrane,Metal-binding,Microtubule,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,SH3 domain,Transmembrane,Transmembrane helix,Wnt signaling pathway, calcium-binding region:1,calcium-binding region:2,chain:Microtubule-actin cross-linking factor 1, isoform 4,chain:Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5,compositionally biased region:Poly-Ser,domain:Actin-binding,domain:CH 1,domain:CH 2,domain:EF-hand 1,domain:EF-hand 2,domain:SH3,modified residue,region of interest:4 X 4 AA tandem repeats of [GS]-S-R-[AR],repeat:Plectin 1,repeat:Plectin 10,repeat:Plectin 11,repeat:Plectin 12,repeat:Plectin 13,repeat:Plectin 14,repeat:Plectin 15,repeat:Plectin 16,repeat:Plectin 17,repeat:Plectin 18,repeat:Plectin 19,repeat:Plectin 2,repeat:Plectin 3,repeat:Plectin 4,repeat:Plectin 5,repeat:Plectin 6,repeat:Plectin 7,repeat:Plectin 8,repeat:Plectin 9,repeat:Spectrin 1,repeat:Spectrin 10,repeat:Spectrin 11,repeat:Spectrin 12,repeat:Spectrin 13,repeat:Spectrin 14,repeat:Spectrin 15,repeat:Spectrin 16,repeat:Spectrin 17,repeat:Spectrin 18,repeat:Spectrin 19,repeat:Spectrin 2,repeat:Spectrin 20,repeat:Spectrin 21,repeat:Spectrin 22,repeat:Spectrin 23,repeat:Spectrin 24,repeat:Spectrin 25,repeat:Spectrin 26,repeat:Spectrin 27,repeat:Spectrin 28,repeat:Spectrin 29,repeat:Spectrin 3,repeat:Spectrin 30,repeat:Spectrin 31,repeat:Spectrin 32,repeat:Spectrin 33,repeat:Spectrin 34,repeat:Spectrin 35,repeat:Spectrin 36,repeat:Spectrin 37,repeat:Spectrin 4,repeat:Spectrin 5,repeat:Spectrin 6,repeat:Spectrin 7,repeat:Spectrin 8,repeat:Spectrin 9,sequence conflict,sequence variant,splice variant, Q9NU22 midasin AAA ATPase 1(MDN1) Homo sapiens General function prediction only, GO:0000027~ribosomal large subunit assembly,GO:0006364~rRNA processing,GO:0006461~protein complex assembly, GO:0005634~nucleus,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0016020~membrane,GO:0030687~preribosome, large subunit precursor,GO:0045111~intermediate filament cytoskeleton, GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016887~ATPase activity,GO:0051082~unfolded protein binding, IPR002035:von Willebrand factor, type A,IPR003593:AAA+ ATPase domain,IPR011704:ATPase, dynein-related, AAA domain,IPR012099:Midasin,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa03008:Ribosome biogenesis in eukaryotes, SM00327:VWA,SM00382:AAA, Acetylation,ATP-binding,Chaperone,Coiled coil,Complete proteome,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat, chain:Midasin,compositionally biased region:Poly-Glu,domain:VWFA,modified residue,nucleotide phosphate-binding region:ATP,sequence variant, P55861 minichromosome maintenance complex component 2 L homeolog(mcm2.L) Xenopus laevis GO:0006268~DNA unwinding involved in DNA replication,GO:0006270~DNA replication initiation,GO:0007049~cell cycle,GO:0030174~regulation of DNA-dependent DNA replication initiation, GO:0000785~chromatin,GO:0005634~nucleus,GO:0042555~MCM complex, GO:0003677~DNA binding,GO:0003678~DNA helicase activity,GO:0005524~ATP binding,GO:0046872~metal ion binding, IPR001208:Mini-chromosome maintenance, DNA-dependent ATPase,IPR008045:DNA replication licensing factor Mcm2,IPR012340:Nucleic acid-binding, OB-fold,IPR018525:Mini-chromosome maintenance, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, xla03030:DNA replication,xla04110:Cell cycle, SM00350:MCM, ATP-binding,Cell cycle,DNA replication,DNA-binding,Helicase,Hydrolase,Metal-binding,Nucleotide-binding,Nucleus,Zinc,Zinc-finger, chain:DNA replication licensing factor mcm2,domain:MCM,nucleotide phosphate-binding region:ATP,sequence conflict,zinc finger region:C4-type, P55862 minichromosome maintenance complex component 5 L homeolog(mcm5.L) Xenopus laevis GO:0006268~DNA unwinding involved in DNA replication,GO:0006270~DNA replication initiation,GO:0007049~cell cycle,GO:0030174~regulation of DNA-dependent DNA replication initiation, GO:0000785~chromatin,GO:0005634~nucleus,GO:0042555~MCM complex, GO:0003678~DNA helicase activity,GO:0003682~chromatin binding,GO:0003688~DNA replication origin binding,GO:0005524~ATP binding, IPR001208:Mini-chromosome maintenance, DNA-dependent ATPase,IPR008048:DNA replication licensing factor Mcm,IPR012340:Nucleic acid-binding, OB-fold,IPR018525:Mini-chromosome maintenance, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, xla03030:DNA replication,xla04110:Cell cycle, SM00350:MCM, ATP-binding,Cell cycle,DNA replication,DNA-binding,Helicase,Hydrolase,Nucleotide-binding,Nucleus, chain:DNA replication licensing factor mcm5-A,domain:MCM,nucleotide phosphate-binding region:ATP, Q9JM52 misshapen-like kinase 1 (zebrafish)(Mink1) Mus musculus GO:0001952~regulation of cell-matrix adhesion,GO:0006468~protein phosphorylation,GO:0006950~response to stress,GO:0007268~chemical synaptic transmission,GO:0007275~multicellular organism development,GO:0016310~phosphorylation,GO:0022407~regulation of cell-cell adhesion,GO:0030334~regulation of cell migration,GO:0031532~actin cytoskeleton reorganization,GO:0035556~intracellular signal transduction,GO:0045060~negative thymic T cell selection,GO:0046330~positive regulation of JNK cascade,GO:0046777~protein autophosphorylation,GO:0048813~dendrite morphogenesis,GO:0070050~neuron cellular homeostasis,GO:2000311~regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity, GO:0005737~cytoplasm,GO:0005794~Golgi apparatus,GO:0005886~plasma membrane,GO:0014069~postsynaptic density,GO:0016020~membrane,GO:0030054~cell junction,GO:0030424~axon,GO:0030425~dendrite,GO:0042995~cell projection,GO:0045202~synapse,GO:0045211~postsynaptic membrane,GO:0070062~extracellular exosome, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0004702~receptor signaling protein serine/threonine kinase activity,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0016740~transferase activity, IPR000719:Protein kinase, catalytic domain,IPR001180:Citron-like,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site, SM00036:CNH,SM00220:S_TKc, Alternative splicing,ATP-binding,Cell junction,Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Direct protein sequencing,Kinase,Membrane,Methylation,Nucleotide-binding,Phosphoprotein,Postsynaptic cell membrane,Proteomics identification,Reference proteome,Serine/threonine-protein kinase,Synapse,Transferase, active site:Proton acceptor,binding site:ATP,chain:Misshapen-like kinase 1,domain:CNH,domain:Protein kinase,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,splice variant, Q86XE3 mitochondrial calcium uptake family member 3(MICU3) Homo sapiens GO:0005739~mitochondrion,GO:0016021~integral component of membrane, GO:0005509~calcium ion binding, IPR002048:EF-hand domain,IPR011992:EF-hand-like domain,IPR018247:EF-Hand 1, calcium-binding site, SM00054:EFh, Calcium,Complete proteome,Membrane,Metal-binding,Mitochondrion,Proteomics identification,Reference proteome,Repeat,Transmembrane,Transmembrane helix, calcium-binding region:1,calcium-binding region:2,chain:EF-hand domain-containing family member A2,compositionally biased region:Poly-Ala,compositionally biased region:Poly-Arg,domain:EF-hand 1,domain:EF-hand 2,domain:EF-hand 3,sequence conflict,transmembrane region, Q08BD8 mitochondrial fission regulator 2(mtfr2) Danio rerio GO:0000266~mitochondrial fission,GO:0009060~aerobic respiration, GO:0005739~mitochondrion, IPR007972:Mitochondrial fission regulator 1, Coiled coil,Complete proteome,Mitochondrion,Proteomics identification,Reference proteome, Q2TBS2 mitochondrial ribosomal protein L21(MRPL21) Bos taurus GO:0006412~translation,GO:0070124~mitochondrial translational initiation,GO:0070125~mitochondrial translational elongation, GO:0005739~mitochondrion,GO:0005743~mitochondrial inner membrane,GO:0005762~mitochondrial large ribosomal subunit,GO:0005840~ribosome, GO:0003735~structural constituent of ribosome,GO:0044822~poly(A) RNA binding, IPR001787:Ribosomal protein L21, bta03010:Ribosome, Complete proteome,Mitochondrion,Reference proteome,Ribonucleoprotein,Ribosomal protein,Transit peptide, chain:39S ribosomal protein L21, mitochondrial,transit peptide:Mitochondrion, Q9VCX3 mitochondrial ribosomal protein L45(mRpL45) Drosophila melanogaster GO:0032543~mitochondrial translation, GO:0005739~mitochondrion,GO:0005762~mitochondrial large ribosomal subunit, GO:0003735~structural constituent of ribosome, IPR007379:Tim44-like domain, SM00978:SM00978, Complete proteome,Mitochondrion,Reference proteome,Ribonucleoprotein,Ribosomal protein,Transit peptide, chain:Probable 39S ribosomal protein L45, mitochondrial,transit peptide:Mitochondrion, Q9VE04 mitochondrial ribosomal protein L55(mRpL55) Drosophila melanogaster GO:0006412~translation,GO:0007275~multicellular organism development,GO:0032543~mitochondrial translation, GO:0005739~mitochondrion,GO:0005762~mitochondrial large ribosomal subunit, GO:0003735~structural constituent of ribosome, IPR018615:Ribosomal protein L55, mitochondrial, Complete proteome,Developmental protein,Mitochondrion,Reference proteome,Ribonucleoprotein,Ribosomal protein,Transit peptide, chain:39S ribosomal protein L55, mitochondrial,transit peptide:Mitochondrion, Q58DQ5 mitochondrial ribosomal protein S9(MRPS9) Bos taurus GO:0000462~maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA),GO:0006412~translation,GO:0070124~mitochondrial translational initiation,GO:0070125~mitochondrial translational elongation, GO:0005730~nucleolus,GO:0005743~mitochondrial inner membrane,GO:0005763~mitochondrial small ribosomal subunit, GO:0003735~structural constituent of ribosome,GO:0044822~poly(A) RNA binding, IPR000754:Ribosomal protein S9,IPR014721:Ribosomal protein S5 domain 2-type fold, subgroup,IPR020568:Ribosomal protein S5 domain 2-type fold,IPR020574:Ribosomal protein S9, conserved site, bta03010:Ribosome, 3D-structure,Alternative splicing,Complete proteome,Direct protein sequencing,Mitochondrion,Reference proteome,Ribonucleoprotein,Ribosomal protein,Transit peptide, chain:28S ribosomal protein S9, mitochondrial,modified residue,sequence conflict,splice variant,transit peptide:Mitochondrion, Q02496 mucin 1, transmembrane(Muc1) Mus musculus GO:0001666~response to hypoxia,GO:0001701~in utero embryonic development,GO:0007565~female pregnancy,GO:0030855~epithelial cell differentiation,GO:0071300~cellular response to retinoic acid, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0009986~cell surface,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0016324~apical plasma membrane, IPR000082:SEA domain,IPR023217:Mucin-1, SM00200:SEA, Autocatalytic cleavage,Cell membrane,Complete proteome,Cytoplasm,Glycoprotein,Lipoprotein,Membrane,Nucleus,Palmitate,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Mucin-1,chain:Mucin-1 subunit alpha,chain:Mucin-1 subunit beta,domain:SEA,glycosylation site:N-linked (GlcNAc...),glycosylation site:O-linked (GalNAc...),lipid moiety-binding region:S-palmitoyl cysteine,modified residue,region of interest:16 X 20 AA approximate tandem repeats,region of interest:Interaction with p53,region of interest:Required for interaction with beta- and gamma-catenins,region of interest:Required for interaction with GSK3B,repeat:1,repeat:10; approximate,repeat:11,repeat:12,repeat:13,repeat:14,repeat:15,repeat:16,repeat:2,repeat:3,repeat:4; approximate,repeat:5; approximate,repeat:6; approximate,repeat:7,repeat:8,repeat:9; approximate,sequence conflict,short sequence motif:Interaction with GRB2,short sequence motif:Interaction with SRC and ESR1,short sequence motif:Required for interaction with AP1S2,signal peptide,site:Cleavage; by autolysis,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, A6H6E2 multimerin 2(Mmrn2) Mus musculus GO:0001525~angiogenesis,GO:0002042~cell migration involved in sprouting angiogenesis,GO:0030948~negative regulation of vascular endothelial growth factor receptor signaling pathway,GO:0090051~negative regulation of cell migration involved in sprouting angiogenesis, GO:0005576~extracellular region,GO:0005578~proteinaceous extracellular matrix,GO:0005604~basement membrane,GO:0005615~extracellular space,GO:0031012~extracellular matrix,GO:0070062~extracellular exosome, IPR001073:Complement C1q protein,IPR008983:Tumour necrosis factor-like domain,IPR011489:EMI domain, SM00110:C1Q, Alternative splicing,Angiogenesis,Coiled coil,Complete proteome,Disulfide bond,Extracellular matrix,Glycoprotein,Reference proteome,Secreted,Signal, chain:Multimerin-2,compositionally biased region:Poly-Ala,disulfide bond,domain:C1q,domain:EMI,glycosylation site:N-linked (GlcNAc...),sequence conflict,signal peptide,splice variant, O75095 multiple EGF like domains 6(MEGF6) Homo sapiens GO:0005576~extracellular region, GO:0005509~calcium ion binding,GO:0005515~protein binding, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR001881:EGF-like calcium-binding,IPR002049:EGF-like, laminin,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR011489:EMI domain,IPR013032:EGF-like, conserved site,IPR018097:EGF-like calcium-binding, conserved site, SM00179:EGF_CA,SM00180:EGF_Lam,SM00181:EGF, Alternative splicing,Calcium,Complete proteome,Disulfide bond,EGF-like domain,Glycoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Secreted,Signal, chain:Multiple epidermal growth factor-like domains protein 6,disulfide bond,domain:EGF-like 1,domain:EGF-like 10,domain:EGF-like 11,domain:EGF-like 12,domain:EGF-like 13,domain:EGF-like 14,domain:EGF-like 15,domain:EGF-like 16,domain:EGF-like 17,domain:EGF-like 18,domain:EGF-like 19,domain:EGF-like 20,domain:EGF-like 21,domain:EGF-like 22,domain:EGF-like 23,domain:EGF-like 24,domain:EGF-like 25,domain:EGF-like 26,domain:EGF-like 27,domain:EGF-like 2; calcium-binding,domain:EGF-like 3,domain:EGF-like 4,domain:EGF-like 5; calcium-binding,domain:EGF-like 6,domain:EGF-like 7,domain:EGF-like 8; calcium-binding,domain:EGF-like 9,domain:EMI,glycosylation site:N-linked (GlcNAc...),sequence variant,signal peptide,splice variant, Q80V70 multiple EGF-like-domains 6(Megf6) Mus musculus GO:0005576~extracellular region, GO:0005509~calcium ion binding, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR001881:EGF-like calcium-binding,IPR002049:EGF-like, laminin,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR011489:EMI domain,IPR013032:EGF-like, conserved site,IPR013111:EGF, extracellular,IPR018097:EGF-like calcium-binding, conserved site,IPR026823:Complement Clr-like EGF domain, SM00179:EGF_CA,SM00180:EGF_Lam,SM00181:EGF, Calcium,Complete proteome,Disulfide bond,EGF-like domain,Glycoprotein,Laminin EGF-like domain,Proteomics identification,Reference proteome,Repeat,Secreted,Signal, chain:Multiple epidermal growth factor-like domains protein 6,disulfide bond,domain:EGF-like 10,domain:EGF-like 11,domain:EGF-like 12,domain:EGF-like 13,domain:EGF-like 14,domain:EGF-like 15,domain:EGF-like 16,domain:EGF-like 17,domain:EGF-like 18,domain:EGF-like 19,domain:EGF-like 1; calcium-binding,domain:EGF-like 20,domain:EGF-like 21,domain:EGF-like 2; calcium-binding,domain:EGF-like 3; calcium-binding,domain:EGF-like 4; calcium-binding,domain:EGF-like 5,domain:EGF-like 6,domain:EGF-like 7,domain:EGF-like 8,domain:EGF-like 9,domain:EMI,glycosylation site:N-linked (GlcNAc...),sequence conflict,signal peptide, O88281 multiple EGF-like-domains 6(Megf6) Rattus norvegicus GO:0005576~extracellular region, GO:0005509~calcium ion binding, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR001881:EGF-like calcium-binding,IPR002049:EGF-like, laminin,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR011489:EMI domain,IPR013032:EGF-like, conserved site,IPR018097:EGF-like calcium-binding, conserved site,IPR026823:Complement Clr-like EGF domain, SM00179:EGF_CA,SM00180:EGF_Lam,SM00181:EGF, Complete proteome,Direct protein sequencing,Disulfide bond,EGF-like domain,Reference proteome,Repeat,Secreted,Signal, chain:Multiple epidermal growth factor-like domains protein 6,disulfide bond,domain:EGF-like 10,domain:EGF-like 11,domain:EGF-like 12,domain:EGF-like 13,domain:EGF-like 14,domain:EGF-like 15,domain:EGF-like 16,domain:EGF-like 17,domain:EGF-like 18,domain:EGF-like 19,domain:EGF-like 1; calcium-binding,domain:EGF-like 20,domain:EGF-like 21,domain:EGF-like 22,domain:EGF-like 23,domain:EGF-like 24,domain:EGF-like 25,domain:EGF-like 26,domain:EGF-like 27,domain:EGF-like 28,domain:EGF-like 29,domain:EGF-like 2; calcium-binding,domain:EGF-like 3,domain:EGF-like 30,domain:EGF-like 31,domain:EGF-like 32,domain:EGF-like 4,domain:EGF-like 5; calcium-binding,domain:EGF-like 6,domain:EGF-like 7,domain:EGF-like 8; calcium-binding,domain:EGF-like 9,domain:EMI,signal peptide, P60882 multiple EGF-like-domains 8(Megf8) Mus musculus GO:0003143~embryonic heart tube morphogenesis,GO:0007368~determination of left/right symmetry,GO:0010468~regulation of gene expression,GO:0030326~embryonic limb morphogenesis,GO:0030509~BMP signaling pathway,GO:0035108~limb morphogenesis,GO:0042074~cell migration involved in gastrulation,GO:0048704~embryonic skeletal system morphogenesis,GO:0048842~positive regulation of axon extension involved in axon guidance,GO:0055113~epiboly involved in gastrulation with mouth forming second,GO:0060287~epithelial cilium movement involved in determination of left/right asymmetry,GO:0060971~embryonic heart tube left/right pattern formation,GO:0060972~left/right pattern formation,GO:0060976~coronary vasculature development,GO:0061371~determination of heart left/right asymmetry,GO:0071907~determination of digestive tract left/right asymmetry,GO:0097094~craniofacial suture morphogenesis,GO:0097155~fasciculation of sensory neuron axon,GO:1900164~nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry, GO:0005634~nucleus,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0070062~extracellular exosome, GO:0005509~calcium ion binding, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR000859:CUB domain,IPR001881:EGF-like calcium-binding,IPR002049:EGF-like, laminin,IPR002165:Plexin,IPR013032:EGF-like, conserved site,IPR015915:Kelch-type beta propeller,IPR016201:Plexin-like fold,IPR018097:EGF-like calcium-binding, conserved site,IPR024731:EGF domain, merozoite surface protein 1-like, SM00042:CUB,SM00179:EGF_CA,SM00180:EGF_Lam,SM00181:EGF,SM00423:PSI, Calcium,Complete proteome,Disulfide bond,EGF-like domain,Glycoprotein,Kelch repeat,Laminin EGF-like domain,Membrane,Phosphoprotein,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Coiled-coil domain-containing protein 72,chain:Multiple epidermal growth factor-like domains protein 8,compositionally biased region:Gly-rich,compositionally biased region:Poly-Leu,compositionally biased region:Pro-rich,disulfide bond,domain:CUB 1,domain:CUB 2,domain:EGF-like 1,domain:EGF-like 2,domain:EGF-like 3; calcium-binding,domain:EGF-like 4,domain:EGF-like 5,domain:Laminin EGF-like 1,domain:Laminin EGF-like 2,domain:Laminin EGF-like 3,domain:Laminin EGF-like 4,domain:PSI 1,domain:PSI 2,domain:PSI 3,domain:PSI 4,domain:PSI 5,domain:PSI 6,domain:PSI 7,glycosylation site:N-linked (GlcNAc...),repeat:Kelch 1,repeat:Kelch 10,repeat:Kelch 11,repeat:Kelch 12,repeat:Kelch 2,repeat:Kelch 3,repeat:Kelch 4,repeat:Kelch 5,repeat:Kelch 6,repeat:Kelch 7,repeat:Kelch 8,repeat:Kelch 9,sequence conflict,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q8VBX6 multiple PDZ domain protein(Mpdz) Mus musculus GO:0007155~cell adhesion,GO:0042552~myelination, GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0005923~bicellular tight junction,GO:0014069~postsynaptic density,GO:0016020~membrane,GO:0016324~apical plasma membrane,GO:0016327~apicolateral plasma membrane,GO:0030054~cell junction,GO:0030425~dendrite,GO:0031410~cytoplasmic vesicle,GO:0042995~cell projection,GO:0043005~neuron projection,GO:0043220~Schmidt-Lanterman incisure,GO:0045202~synapse,GO:0045211~postsynaptic membrane, GO:0005515~protein binding,GO:0008022~protein C-terminus binding, IPR001478:PDZ domain,IPR004172:L27,IPR015132:L27-2, mmu04530:Tight junction, SM00228:PDZ,SM00569:L27, 3D-structure,Alternative splicing,Cell junction,Cell membrane,Cell projection,Complete proteome,Membrane,Methylation,Phosphoprotein,Postsynaptic cell membrane,Proteomics identification,Reference proteome,Repeat,Synapse,Synaptosome,Tight junction, chain:Multiple PDZ domain protein,domain:L27,domain:PDZ 1,domain:PDZ 10,domain:PDZ 11,domain:PDZ 12,domain:PDZ 13,domain:PDZ 2,domain:PDZ 3,domain:PDZ 4,domain:PDZ 5,domain:PDZ 6,domain:PDZ 7,domain:PDZ 8,domain:PDZ 9,modified residue,sequence conflict,sequence variant,splice variant, Q24247 multiple edematous wings(mew) Drosophila melanogaster GO:0007015~actin filament organization,GO:0007155~cell adhesion,GO:0007157~heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,GO:0007160~cell-matrix adhesion,GO:0007229~integrin-mediated signaling pathway,GO:0007411~axon guidance,GO:0007414~axonal defasciculation,GO:0007424~open tracheal system development,GO:0007426~tracheal outgrowth, open tracheal system,GO:0007427~epithelial cell migration, open tracheal system,GO:0007431~salivary gland development,GO:0007432~salivary gland boundary specification,GO:0007435~salivary gland morphogenesis,GO:0007475~apposition of dorsal and ventral imaginal disc-derived wing surfaces,GO:0007476~imaginal disc-derived wing morphogenesis,GO:0007494~midgut development,GO:0007608~sensory perception of smell,GO:0016203~muscle attachment,GO:0016337~single organismal cell-cell adhesion,GO:0016477~cell migration,GO:0030154~cell differentiation,GO:0033627~cell adhesion mediated by integrin,GO:0034446~substrate adhesion-dependent cell spreading,GO:0035160~maintenance of epithelial integrity, open tracheal system,GO:0048567~ectodermal digestive tract morphogenesis, GO:0005887~integral component of plasma membrane,GO:0005925~focal adhesion,GO:0008305~integrin complex,GO:0009925~basal plasma membrane,GO:0016324~apical plasma membrane,GO:0016328~lateral plasma membrane, GO:0004872~receptor activity,GO:0046982~protein heterodimerization activity,GO:0050839~cell adhesion molecule binding,GO:0050840~extracellular matrix binding, IPR000413:Integrin alpha chain,IPR013517:FG-GAP repeat,IPR013519:Integrin alpha beta-propellor,IPR013649:Integrin alpha-2,IPR018184:Integrin alpha chain, C-terminal cytoplasmic region, conserved site, SM00191:Int_alpha, Alternative splicing,Cell adhesion,Cell membrane,Cleavage on pair of basic residues,Complete proteome,Direct protein sequencing,Disulfide bond,Glycoprotein,Integrin,Membrane,Proteomics identification,Receptor,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Integrin alpha-PS1,chain:Integrin alpha-PS1 heavy chain,chain:Integrin alpha-PS1 light chain,glycosylation site:N-linked (GlcNAc...),repeat:FG-GAP 1,repeat:FG-GAP 2,repeat:FG-GAP 3,repeat:FG-GAP 4,repeat:FG-GAP 5,repeat:FG-GAP 6,repeat:FG-GAP 7,sequence conflict,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, P23508 mutated in colorectal cancers(MCC) Homo sapiens GO:0007165~signal transduction,GO:0010633~negative regulation of epithelial cell migration,GO:0016055~Wnt signaling pathway,GO:0045184~establishment of protein localization,GO:0050680~negative regulation of epithelial cell proliferation,GO:0090090~negative regulation of canonical Wnt signaling pathway, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0030027~lamellipodium, GO:0004872~receptor activity,GO:0005515~protein binding, IPR019536:Usher syndrome type-1C protein-binding protein 1, PDZ domain, 114500~Colorectal cancer, somatic, Alternative splicing,Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Membrane,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Tumor suppressor,Wnt signaling pathway, chain:Colorectal mutant cancer protein,modified residue,sequence conflict,sequence variant,splice variant, Q3UR85 myelin regulatory factor(Myrf) Mus musculus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006508~proteolysis,GO:0014003~oligodendrocyte development,GO:0022010~central nervous system myelination,GO:0030154~cell differentiation,GO:0031643~positive regulation of myelination,GO:0032286~central nervous system myelin maintenance,GO:0045893~positive regulation of transcription, DNA-templated,GO:0048709~oligodendrocyte differentiation, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005783~endoplasmic reticulum,GO:0005789~endoplasmic reticulum membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0008233~peptidase activity,GO:0016787~hydrolase activity,GO:0043565~sequence-specific DNA binding, IPR008967:p53-like transcription factor, DNA-binding,IPR024061:NDT80 DNA-binding domain,IPR025719:Myelin gene regulatory factor C-terminal domain 2,IPR026932:Myelin gene regulatory factor C-terminal domain 1,IPR026933:Myelin gene regulatory factor, Acetylation,Activator,Alternative splicing,Autocatalytic cleavage,Coiled coil,Complete proteome,Cytoplasm,Differentiation,DNA-binding,Endoplasmic reticulum,Glycoprotein,Hydrolase,Membrane,Nucleus,Protease,Proteomics identification,Reference proteome,Transcription,Transcription regulation,Transmembrane,Transmembrane helix, chain:Myelin gene regulatory factor,compositionally biased region:Pro-rich,DNA-binding region:NDT80,modified residue,splice variant,transmembrane region, O54826 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10(Mllt10) Mus musculus GO:0045944~positive regulation of transcription from RNA polymerase II promoter, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0016021~integral component of membrane,GO:0043234~protein complex, GO:0008270~zinc ion binding,GO:0046872~metal ion binding, IPR001965:Zinc finger, PHD-type,IPR011011:Zinc finger, FYVE/PHD-type,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR019786:Zinc finger, PHD-type, conserved site,IPR019787:Zinc finger, PHD-finger, SM00249:PHD, Coiled coil,Complete proteome,Direct protein sequencing,Isopeptide bond,Membrane,Metal-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Ubl conjugation,Zinc,Zinc-finger, chain:Protein AF-10,compositionally biased region:Gln-rich,compositionally biased region:Glu/Lys-rich,domain:Leucine-zipper,modified residue,zinc finger region:C4-type,zinc finger region:PHD-type 1,zinc finger region:PHD-type 2, Q99MD8 myoneurin(Mynn) Mus musculus Transcription / Cell division and chromosome partitioning, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0046872~metal ion binding, IPR000210:BTB/POZ-like,IPR007087:Zinc finger, C2H2,IPR011333:BTB/POZ fold,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00225:BTB,SM00355:ZnF_C2H2, Alternative splicing,Complete proteome,DNA-binding,Metal-binding,Nucleus,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Myoneurin,compositionally biased region:Poly-Lys,domain:BTB,sequence conflict,short sequence motif:Nuclear localization signal,splice variant,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8, Q12965 myosin IE(MYO1E) Homo sapiens GO:0001570~vasculogenesis,GO:0001701~in utero embryonic development,GO:0003094~glomerular filtration,GO:0006807~nitrogen compound metabolic process,GO:0006897~endocytosis,GO:0030048~actin filament-based movement,GO:0032836~glomerular basement membrane development,GO:0035166~post-embryonic hemopoiesis,GO:0048008~platelet-derived growth factor receptor signaling pathway,GO:0072015~glomerular visceral epithelial cell development, GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005903~brush border,GO:0005911~cell-cell junction,GO:0005912~adherens junction,GO:0015629~actin cytoskeleton,GO:0016459~myosin complex,GO:0030136~clathrin-coated vesicle,GO:0045334~clathrin-coated endocytic vesicle,GO:0070062~extracellular exosome, GO:0000146~microfilament motor activity,GO:0003774~motor activity,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0005524~ATP binding,GO:0035091~phosphatidylinositol binding,GO:0042623~ATPase activity, coupled,GO:0051015~actin filament binding, IPR000048:IQ motif, EF-hand binding site,IPR001452:Src homology-3 domain,IPR001609:Myosin head, motor domain,IPR010926:Myosin tail 2,IPR027417:P-loop containing nucleoside triphosphate hydrolase, 614131~Glomerulosclerosis, focal segmental, 6, SM00242:MYSc,SM00326:SH3, Actin-binding,ATP-binding,Calmodulin-binding,Cell junction,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Cytoskeleton,Disease mutation,Lipid-binding,Motor protein,Myosin,Nucleotide-binding,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,SH3 domain, chain:Myosin-Ie,domain:IQ,domain:Myosin head-like,domain:SH3,modified residue,nucleotide phosphate-binding region:ATP,region of interest:Actin-binding,sequence conflict, Q9Y4I1 myosin VA(MYO5A) Homo sapiens Cytoskeleton, GO:0006810~transport,GO:0006887~exocytosis,GO:0006892~post-Golgi vesicle-mediated transport,GO:0007268~chemical synaptic transmission,GO:0007601~visual perception,GO:0016192~vesicle-mediated transport,GO:0030048~actin filament-based movement,GO:0030050~vesicle transport along actin filament,GO:0030073~insulin secretion,GO:0030318~melanocyte differentiation,GO:0031585~regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity,GO:0031987~locomotion involved in locomotory behavior,GO:0032252~secretory granule localization,GO:0032402~melanosome transport,GO:0032869~cellular response to insulin stimulus,GO:0042438~melanin biosynthetic process,GO:0042476~odontogenesis,GO:0042552~myelination,GO:0042759~long-chain fatty acid biosynthetic process,GO:0050808~synapse organization,GO:0051643~endoplasmic reticulum localization,GO:0072659~protein localization to plasma membrane,GO:1903358~regulation of Golgi organization, GO:0001726~ruffle,GO:0001750~photoreceptor outer segment,GO:0005737~cytoplasm,GO:0005764~lysosome,GO:0005769~early endosome,GO:0005770~late endosome,GO:0005777~peroxisome,GO:0005783~endoplasmic reticulum,GO:0005794~Golgi apparatus,GO:0005829~cytosol,GO:0005882~intermediate filament,GO:0005884~actin filament,GO:0016020~membrane,GO:0016459~myosin complex,GO:0030426~growth cone,GO:0031982~vesicle,GO:0032433~filopodium tip,GO:0032593~insulin-responsive compartment,GO:0035371~microtubule plus-end,GO:0042470~melanosome,GO:0042641~actomyosin,GO:0043005~neuron projection,GO:0043025~neuronal cell body,GO:0055037~recycling endosome,GO:0070062~extracellular exosome, GO:0000146~microfilament motor activity,GO:0003774~motor activity,GO:0003779~actin binding,GO:0005509~calcium ion binding,GO:0005516~calmodulin binding,GO:0005524~ATP binding,GO:0017137~Rab GTPase binding,GO:0044822~poly(A) RNA binding, IPR000048:IQ motif, EF-hand binding site,IPR001609:Myosin head, motor domain,IPR002710:Dilute,IPR008989:Myosin S1 fragment, N-terminal,IPR027417:P-loop containing nucleoside triphosphate hydrolase, 214450~Griscelli syndrome, type 1, SM00015:IQ,SM00242:MYSc,SM01132:SM01132, 3D-structure,Acetylation,Actin-binding,Alternative splicing,ATP-binding,Calmodulin-binding,Coiled coil,Complete proteome,Motor protein,Myosin,Nucleotide-binding,Phosphoprotein,Polymorphism,Protein transport,Proteomics identification,Reference proteome,Repeat,Transport, chain:Myosin-Va,domain:Dilute,domain:IQ 1,domain:IQ 2,domain:IQ 3,domain:IQ 4,domain:IQ 5,domain:IQ 6,domain:Myosin head-like,modified residue,nucleotide phosphate-binding region:ATP,region of interest:Actin-binding,sequence conflict,sequence variant,splice variant, Q9ULV0 myosin VB(MYO5B) Homo sapiens GO:0003091~renal water homeostasis,GO:0015031~protein transport,GO:0016192~vesicle-mediated transport,GO:0032439~endosome localization, GO:0016459~myosin complex,GO:0030659~cytoplasmic vesicle membrane,GO:0043234~protein complex,GO:0045179~apical cortex,GO:0055037~recycling endosome,GO:0070062~extracellular exosome, GO:0000146~microfilament motor activity,GO:0003774~motor activity,GO:0003779~actin binding,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0005524~ATP binding,GO:0017137~Rab GTPase binding, IPR000048:IQ motif, EF-hand binding site,IPR001609:Myosin head, motor domain,IPR002710:Dilute,IPR027417:P-loop containing nucleoside triphosphate hydrolase, 251850~Microvillus inclusion disease, SM00015:IQ,SM00242:MYSc,SM01132:SM01132, 3D-structure,Acetylation,Actin-binding,Alternative splicing,ATP-binding,Calmodulin-binding,Coiled coil,Complete proteome,Cytoplasm,Disease mutation,Motor protein,Myosin,Nucleotide-binding,Phosphoprotein,Polymorphism,Protein transport,Proteomics identification,Reference proteome,Repeat,Transport, chain:Myosin-Vb,compositionally biased region:Arg-rich,domain:Dilute,domain:IQ 1,domain:IQ 2,domain:IQ 3,domain:IQ 4,domain:IQ 5,domain:IQ 6,domain:Myosin head-like,modified residue,nucleotide phosphate-binding region:ATP,region of interest:Actin-binding,sequence variant, A8T6P4 myosin VIIA and Rab interacting protein(myrip) Danio rerio GO:0006886~intracellular protein transport,GO:0030050~vesicle transport along actin filament, GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0030133~transport vesicle,GO:0030864~cortical actin cytoskeleton,GO:0031410~cytoplasmic vesicle,GO:0048471~perinuclear region of cytoplasm, GO:0003779~actin binding,GO:0005515~protein binding,GO:0017022~myosin binding,GO:0017137~Rab GTPase binding,GO:0046872~metal ion binding, IPR006788:Rab effector MyRIP/Melanophilin,IPR010911:Rab-binding domain,IPR011011:Zinc finger, FYVE/PHD-type,IPR013083:Zinc finger, RING/FYVE/PHD-type, Coiled coil,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Metal-binding,Reference proteome,Zinc,Zinc-finger, Q92614 myosin XVIIIA(MYO18A) Homo sapiens GO:0006259~DNA metabolic process,GO:0007030~Golgi organization,GO:0016477~cell migration,GO:0031032~actomyosin structure organization,GO:0043030~regulation of macrophage activation,GO:0043066~negative regulation of apoptotic process,GO:0048194~Golgi vesicle budding,GO:0050714~positive regulation of protein secretion,GO:0090161~Golgi ribbon formation,GO:0090164~asymmetric Golgi ribbon formation,GO:1903028~positive regulation of opsonization, GO:0000139~Golgi membrane,GO:0005654~nucleoplasm,GO:0005793~endoplasmic reticulum-Golgi intermediate compartment,GO:0005794~Golgi apparatus,GO:0005802~trans-Golgi network,GO:0016020~membrane,GO:0016459~myosin complex,GO:0042641~actomyosin, GO:0003677~DNA binding,GO:0003774~motor activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008094~DNA-dependent ATPase activity,GO:0016887~ATPase activity,GO:0043531~ADP binding,GO:0044822~poly(A) RNA binding,GO:0051015~actin filament binding, IPR000048:IQ motif, EF-hand binding site,IPR001478:PDZ domain,IPR001609:Myosin head, motor domain,IPR002928:Myosin tail,IPR020587:DNA recombination/repair protein RecA, monomer-monomer interface,IPR027401:Myosin-like IQ motif-containing domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00015:IQ,SM00228:PDZ,SM00242:MYSc, Alternative splicing,ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Golgi apparatus,Motor protein,Myosin,Nucleotide-binding,Phosphoprotein,Polymorphism,Proteomics identification,Receptor,Reference proteome, chain:Myosin-XVIIIa,domain:IQ,domain:Myosin head-like,domain:PDZ,modified residue,mutagenesis site,nucleotide phosphate-binding region:ATP,sequence conflict,sequence variant,short sequence motif:Interaction with actin,splice variant, P10587 myosin, heavy chain 11, smooth muscle(MYH11) Gallus gallus GO:0006939~smooth muscle contraction,GO:0030241~skeletal muscle myosin thick filament assembly,GO:0048251~elastic fiber assembly,GO:0048739~cardiac muscle fiber development,GO:0098779~mitophagy in response to mitochondrial depolarization, GO:0016459~myosin complex,GO:0030016~myofibril,GO:0032982~myosin filament,GO:0070062~extracellular exosome, GO:0003774~motor activity,GO:0003779~actin binding,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0005524~ATP binding,GO:0008307~structural constituent of muscle, IPR000048:IQ motif, EF-hand binding site,IPR001609:Myosin head, motor domain,IPR002928:Myosin tail,IPR004009:Myosin, N-terminal, SH3-like,IPR027401:Myosin-like IQ motif-containing domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, gga04530:Tight junction, SM00015:IQ,SM00242:MYSc, 3D-structure,Actin-binding,ATP-binding,Calmodulin-binding,Coiled coil,Complete proteome,Cytoplasm,Direct protein sequencing,Methylation,Motor protein,Muscle protein,Myosin,Nucleotide-binding,Reference proteome,Thick filament, chain:Myosin-11,domain:IQ,domain:Myosin head-like,helix,modified residue,nucleotide phosphate-binding region:ATP,region of interest:Actin-binding,region of interest:Rodlike tail (S2 and LMM domains),sequence conflict,strand,turn, Q5U581 myotubularin related protein 10 S homeolog(mtmr10.S) Xenopus laevis IPR010569:Myotubularin-related,IPR011993:Pleckstrin homology-like domain,IPR022587:Myotubularin-associated, chain:Myotubularin-related protein 10-A,compositionally biased region:Poly-Gly,domain:Myotubularin phosphatase, Q5F452 myotubularin related protein 8(MTMR8) Gallus gallus GO:0010506~regulation of autophagy,GO:0035335~peptidyl-tyrosine dephosphorylation,GO:0046856~phosphatidylinositol dephosphorylation, GO:0005635~nuclear envelope, GO:0004438~phosphatidylinositol-3-phosphatase activity,GO:0004725~protein tyrosine phosphatase activity,GO:0052629~phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity, IPR003595:Protein-tyrosine phosphatase, catalytic,IPR010569:Myotubularin-related,IPR011993:Pleckstrin homology-like domain,IPR016130:Protein-tyrosine phosphatase, active site, gga00562:Inositol phosphate metabolism,gga01100:Metabolic pathways,gga04070:Phosphatidylinositol signaling system, SM00404:PTPc_motif, Coiled coil,Complete proteome,Hydrolase,Nucleus,Reference proteome, binding site:Substrate,chain:Myotubularin-related protein 8,domain:Myotubularin phosphatase,region of interest:Substrate binding, P18293 natriuretic peptide receptor 1(Npr1) Mus musculus GO:0006182~cGMP biosynthetic process,GO:0006468~protein phosphorylation,GO:0007166~cell surface receptor signaling pathway,GO:0007168~receptor guanylyl cyclase signaling pathway,GO:0008217~regulation of blood pressure,GO:0009190~cyclic nucleotide biosynthetic process,GO:0030828~positive regulation of cGMP biosynthetic process,GO:0035556~intracellular signal transduction,GO:0042417~dopamine metabolic process,GO:0048662~negative regulation of smooth muscle cell proliferation,GO:0050880~regulation of blood vessel size, GO:0005622~intracellular,GO:0005886~plasma membrane,GO:0008074~guanylate cyclase complex, soluble,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0043235~receptor complex, GO:0000166~nucleotide binding,GO:0004383~guanylate cyclase activity,GO:0004672~protein kinase activity,GO:0005524~ATP binding,GO:0005525~GTP binding,GO:0016829~lyase activity,GO:0016849~phosphorus-oxygen lyase activity,GO:0016941~natriuretic peptide receptor activity,GO:0017046~peptide hormone binding,GO:0019901~protein kinase binding,GO:0042562~hormone binding, IPR000719:Protein kinase, catalytic domain,IPR001054:Adenylyl cyclase class-3/4/guanylyl cyclase,IPR001170:Natriuretic peptide receptor,IPR001245:Serine-threonine/tyrosine-protein kinase catalytic domain,IPR001828:Extracellular ligand-binding receptor,IPR011009:Protein kinase-like domain,IPR018297:Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site, mmu00230:Purine metabolism,mmu04022:cGMP-PKG signaling pathway,mmu04024:cAMP signaling pathway,mmu04270:Vascular smooth muscle contraction,mmu04921:Oxytocin signaling pathway,mmu04923:Regulation of lipolysis in adipocytes,mmu04924:Renin secretion,mmu04925:Aldosterone synthesis and secretion, SM00044:CYCc, cGMP biosynthesis,Chloride,Coiled coil,Complete proteome,Disulfide bond,Glycoprotein,GTP-binding,Lyase,Membrane,Nucleotide-binding,Phosphoprotein,Receptor,Reference proteome,Signal,Transmembrane,Transmembrane helix,Vasoactive, binding site:Chloride,binding site:Chloride; via amide nitrogen,chain:Atrial natriuretic peptide receptor 1,disulfide bond,domain:Guanylate cyclase,domain:Protein kinase,glycosylation site:N-linked (GlcNAc...),modified residue,sequence conflict,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q8K4Q6 nei endonuclease VIII-like 1 (E. coli)(Neil1) Mus musculus GO:0006281~DNA repair,GO:0006284~base-excision repair,GO:0006289~nucleotide-excision repair,GO:0006974~cellular response to DNA damage stimulus,GO:0006979~response to oxidative stress,GO:0008152~metabolic process,GO:0032074~negative regulation of nuclease activity, GO:0005634~nucleus,GO:0005694~chromosome,GO:0005737~cytoplasm,GO:0005815~microtubule organizing center,GO:0005856~cytoskeleton, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003684~damaged DNA binding,GO:0003824~catalytic activity,GO:0003906~DNA-(apurinic or apyrimidinic site) lyase activity,GO:0008022~protein C-terminus binding,GO:0008270~zinc ion binding,GO:0016787~hydrolase activity,GO:0016798~hydrolase activity, acting on glycosyl bonds,GO:0016799~hydrolase activity, hydrolyzing N-glycosyl compounds,GO:0016829~lyase activity,GO:0019104~DNA N-glycosylase activity, IPR010979:Ribosomal protein S13-like, H2TH,IPR012319:DNA glycosylase/AP lyase, catalytic domain,IPR015371:Endonuclease VIII-like 1, DNA binding,IPR015886:DNA glycosylase/AP lyase, H2TH DNA-binding, mmu03410:Base excision repair, SM00898:SM00898,SM01232:SM01232, Alternative splicing,Chromosome,Complete proteome,Cytoplasm,Cytoskeleton,DNA damage,DNA repair,DNA-binding,Glycosidase,Hydrolase,Lyase,Multifunctional enzyme,Nucleus,Reference proteome, active site:Proton donor,active site:Proton donor; for beta-elimination activity,active site:Schiff-base intermediate with DNA,binding site:DNA,chain:Endonuclease VIII-like 1,splice variant, Q8K203 nei like 3 (E. coli)(Neil3) Mus musculus DNA replication, recombination, and repair, GO:0006281~DNA repair,GO:0006284~base-excision repair,GO:0006289~nucleotide-excision repair,GO:0006974~cellular response to DNA damage stimulus,GO:0008152~metabolic process, GO:0005634~nucleus,GO:0005654~nucleoplasm, GO:0000405~bubble DNA binding,GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003684~damaged DNA binding,GO:0003690~double-stranded DNA binding,GO:0003697~single-stranded DNA binding,GO:0003824~catalytic activity,GO:0003906~DNA-(apurinic or apyrimidinic site) lyase activity,GO:0008270~zinc ion binding,GO:0016787~hydrolase activity,GO:0016798~hydrolase activity, acting on glycosyl bonds,GO:0016799~hydrolase activity, hydrolyzing N-glycosyl compounds,GO:0016829~lyase activity,GO:0019104~DNA N-glycosylase activity,GO:0046872~metal ion binding, IPR000214:Zinc finger, DNA glycosylase/AP lyase-type,IPR001876:Zinc finger, RanBP2-type,IPR010666:Zinc finger, GRF-type,IPR010979:Ribosomal protein S13-like, H2TH,IPR012319:DNA glycosylase/AP lyase, catalytic domain,IPR015886:DNA glycosylase/AP lyase, H2TH DNA-binding,IPR015887:DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site, mmu03410:Base excision repair, SM00547:ZnF_RBZ,SM01232:SM01232, 3D-structure,Alternative splicing,Complete proteome,DNA damage,DNA repair,DNA-binding,Glycosidase,Hydrolase,Lyase,Metal-binding,Multifunctional enzyme,Nucleus,Phosphoprotein,Polymorphism,Reference proteome,Zinc,Zinc-finger, binding site:DNA,chain:Endonuclease VIII-like 3,sequence variant,splice variant,zinc finger region:FPG-type,zinc finger region:RanBP2-type, A1L0Y2 neuralized E3 ubiquitin protein ligase 4(neurl4) Xenopus tropicalis GO:0005814~centriole, IPR006573:NEUZ,IPR013320:Concanavalin A-like lectin/glucanase, subgroup, SM00588:NEUZ, Complete proteome,Cytoplasm,Cytoskeleton,Reference proteome,Repeat,Ubl conjugation,Ubl conjugation pathway, chain:Neuralized-like protein 4,domain:NHR 1,domain:NHR 2,domain:NHR 3,domain:NHR 4,domain:NHR 5,domain:NHR 6, Q9ULB1 neurexin 1(NRXN1) Homo sapiens GO:0001525~angiogenesis,GO:0007157~heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules,GO:0007158~neuron cell-cell adhesion,GO:0007165~signal transduction,GO:0007268~chemical synaptic transmission,GO:0007269~neurotransmitter secretion,GO:0007411~axon guidance,GO:0007416~synapse assembly,GO:0007612~learning,GO:0016339~calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules,GO:0021707~cerebellar granule cell differentiation,GO:0023041~neuronal signal transduction,GO:0030534~adult behavior,GO:0035176~social behavior,GO:0035418~protein localization to synapse,GO:0042297~vocal learning,GO:0045184~establishment of protein localization,GO:0050885~neuromuscular process controlling balance,GO:0051490~negative regulation of filopodium assembly,GO:0051965~positive regulation of synapse assembly,GO:0051968~positive regulation of synaptic transmission, glutamatergic,GO:0060134~prepulse inhibition,GO:0061178~regulation of insulin secretion involved in cellular response to glucose stimulus,GO:0071625~vocalization behavior,GO:0090004~positive regulation of establishment of protein localization to plasma membrane,GO:0090126~protein complex assembly involved in synapse maturation,GO:0090129~positive regulation of synapse maturation,GO:0097091~synaptic vesicle clustering,GO:0097104~postsynaptic membrane assembly,GO:0097105~presynaptic membrane assembly,GO:0097112~gamma-aminobutyric acid receptor clustering,GO:0097114~NMDA glutamate receptor clustering,GO:0097116~gephyrin clustering involved in postsynaptic density assembly,GO:0097117~guanylate kinase-associated protein clustering,GO:0097118~neuroligin clustering involved in postsynaptic membrane assembly,GO:0097119~postsynaptic density protein 95 clustering,GO:0097120~receptor localization to synapse,GO:2000310~regulation of N-methyl-D-aspartate selective glutamate receptor activity,GO:2000311~regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity,GO:2000463~positive regulation of excitatory postsynaptic potential,GO:2000821~regulation of grooming behavior, GO:0005783~endoplasmic reticulum,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0009986~cell surface,GO:0016021~integral component of membrane,GO:0030054~cell junction,GO:0030139~endocytic vesicle,GO:0031965~nuclear membrane,GO:0031982~vesicle,GO:0042734~presynaptic membrane,GO:0043025~neuronal cell body,GO:0043234~protein complex,GO:0044295~axonal growth cone,GO:0098793~presynapse, GO:0004872~receptor activity,GO:0004888~transmembrane signaling receptor activity,GO:0005102~receptor binding,GO:0005246~calcium channel regulator activity,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0033130~acetylcholine receptor binding,GO:0046872~metal ion binding,GO:0048306~calcium-dependent protein binding,GO:0050839~cell adhesion molecule binding,GO:0097109~neuroligin family protein binding, IPR000152:EGF-type aspartate/asparagine hydroxylation site,IPR000742:Epidermal growth factor-like domain,IPR001791:Laminin G domain,IPR003585:Neurexin/syndecan/glycophorin C,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR027158:Neurexin-1-alpha, hsa04514:Cell adhesion molecules (CAMs), 614325~Pitt-Hopkins-like syndrome 2,614332~Schizophrenia, susceptibility to, 17, SM00181:EGF,SM00282:LamG,SM00294:4.1m, 3D-structure,Alternative promoter usage,Alternative splicing,Angiogenesis,Calcium,Cell adhesion,Cell junction,Cell membrane,Complete proteome,Disulfide bond,EGF-like domain,Glycoprotein,Membrane,Metal-binding,Polymorphism,Proteomics identification,Reference proteome,Repeat,Signal,Synapse,Transmembrane,Transmembrane helix, chain:Neurexin-1-alpha,chain:Neurexin-1-beta,compositionally biased region:Poly-Ala,compositionally biased region:Poly-Thr,disulfide bond,domain:EGF-like 1,domain:EGF-like 2,domain:EGF-like 3,domain:Laminin G-like,domain:Laminin G-like 1,domain:Laminin G-like 2,domain:Laminin G-like 3,domain:Laminin G-like 4,domain:Laminin G-like 5,domain:Laminin G-like 6,glycosylation site:N-linked (GlcNAc...),helix,metal ion-binding site:Calcium,metal ion-binding site:Calcium; via carbonyl oxygen,sequence conflict,sequence variant,signal peptide,splice variant,strand,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region,turn, Q28IV8 neuroguidin(ngdn) Xenopus tropicalis GO:0000462~maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA),GO:0006417~regulation of translation, GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0032040~small-subunit processome, IPR007146:Sas10/Utp3/C1D, Complete proteome,Cytoplasm,Nucleus,Reference proteome,Repressor,Translation regulation, chain:Neuroguidin, Q8IVL0 neuron navigator 3(NAV3) Homo sapiens GO:0005640~nuclear outer membrane, GO:0005524~ATP binding, IPR001715:Calponin homology domain,IPR003593:AAA+ ATPase domain,IPR003959:ATPase, AAA-type, core,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00033:CH,SM00382:AAA, Alternative splicing,Chromosomal rearrangement,Coiled coil,Complete proteome,Membrane,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:Neuron navigator 3,compositionally biased region:Poly-Gln,compositionally biased region:Poly-Lys,compositionally biased region:Ser-rich,domain:CH,modified residue,sequence conflict,sequence variant,splice variant, Q90773 neurotrimin(NTM) Gallus gallus GO:0007155~cell adhesion, GO:0005886~plasma membrane,GO:0031225~anchored component of membrane, IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR007110:Immunoglobulin-like domain,IPR013098:Immunoglobulin I-set,IPR013151:Immunoglobulin,IPR013783:Immunoglobulin-like fold, SM00408:IGc2,SM00409:IG, Alternative splicing,Cell adhesion,Cell membrane,Complete proteome,Disulfide bond,Glycoprotein,GPI-anchor,Immunoglobulin domain,Lipoprotein,Membrane,Reference proteome,Repeat,Signal, chain:Protein CEPU-1,disulfide bond,domain:Ig-like C2-type 1,domain:Ig-like C2-type 2,domain:Ig-like C2-type 3,glycosylation site:N-linked (GlcNAc...),lipid moiety-binding region:GPI-anchor amidated serine,propeptide:Removed in mature form,signal peptide,splice variant, Q91W63 nicotinamide riboside kinase 1(Nmrk1) Mus musculus GO:0009435~NAD biosynthetic process,GO:0016310~phosphorylation,GO:0019363~pyridine nucleotide biosynthetic process, GO:0000166~nucleotide binding,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0016740~transferase activity,GO:0046872~metal ion binding,GO:0050262~ribosylnicotinamide kinase activity, IPR027417:P-loop containing nucleoside triphosphate hydrolase, mmu00760:Nicotinate and nicotinamide metabolism,mmu01100:Metabolic pathways, ATP-binding,Complete proteome,Kinase,Magnesium,Metal-binding,Nucleotide-binding,Pyridine nucleotide biosynthesis,Reference proteome,Transferase, active site:Proton acceptor,binding site:ATP,binding site:Substrate,chain:Nicotinamide riboside kinase 1,metal ion-binding site:Magnesium,nucleotide phosphate-binding region:ATP, Q9YHY6 non-SMC condensin I complex subunit D2 S homeolog(ncapd2.S) Xenopus laevis Chromatin structure and dynamics / Cell division and chromosome partitioning, GO:0007076~mitotic chromosome condensation,GO:0051301~cell division, GO:0005634~nucleus,GO:0005694~chromosome,GO:0005829~cytosol, IPR007673:Condensin subunit 1,IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold,IPR024324:Condensin complex, subunit 1, N-terminal,IPR026971:Condensin subunit 1/Condensin-2 complex subunit D3, PIRSF017127:chromosome condensation complex condensin, subunit D2, Cell cycle,Cell division,Chromosome,Cytoplasm,DNA condensation,Mitosis,Nucleus,Phosphoprotein,Repeat, chain:Condensin complex subunit 1,modified residue,region of interest:Interaction with XCAP-E and XCAP-C,sequence conflict,short sequence motif:Bipartite nuclear localization signal, Q803E1 nuclear cap binding subunit 3(ncbp3) Danio rerio GO:0006370~7-methylguanosine mRNA capping,GO:0006397~mRNA processing,GO:0006810~transport,GO:0051028~mRNA transport, GO:0005634~nucleus,GO:0005737~cytoplasm, GO:0000166~nucleotide binding,GO:0000340~RNA 7-methylguanosine cap binding,GO:0003723~RNA binding,GO:0003729~mRNA binding, IPR012677:Nucleotide-binding, alpha-beta plait,IPR019416:Protein of unknown function DUF2414, Complete proteome,Cytoplasm,mRNA capping,mRNA processing,mRNA transport,Nucleus,Proteomics identification,Reference proteome,RNA-binding,Transport, chain:Uncharacterized protein C17orf85 homolog,compositionally biased region:Asp-rich,compositionally biased region:Gly-rich,compositionally biased region:Poly-Glu, Q5ZL67 nuclear factor, erythroid 2 like 1(NFE2L1) Gallus gallus GO:0006351~transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0030218~erythrocyte differentiation,GO:0034599~cellular response to oxidative stress,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005789~endoplasmic reticulum membrane,GO:0016021~integral component of membrane, GO:0000976~transcription regulatory region sequence-specific DNA binding,GO:0000980~RNA polymerase II distal enhancer sequence-specific DNA binding,GO:0001190~transcriptional activator activity, RNA polymerase II transcription factor binding,GO:0001205~transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding,GO:0003700~transcription factor activity, sequence-specific DNA binding, IPR004826:Basic leucine zipper domain, Maf-type,IPR004827:Basic-leucine zipper domain,IPR008917:Eukaryotic transcription factor, Skn-1-like, DNA-binding, SM00338:BRLZ, Activator,Coiled coil,Complete proteome,DNA-binding,Endoplasmic reticulum,Membrane,Nucleus,Reference proteome,Signal-anchor,Transcription,Transcription regulation,Transmembrane,Transmembrane helix, chain:Nuclear factor erythroid 2-related factor 1,compositionally biased region:Ser-rich,DNA-binding region:Basic motif,domain:Leucine-zipper,short sequence motif:Nuclear localization signal, A2RRX6 nuclear protein, ataxia-telangiectasia locus S homeolog(npat.S) Xenopus laevis GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007049~cell cycle, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0015030~Cajal body,GO:0097504~Gemini of coiled bodies, IPR006594:LisH dimerisation motif, Activator,Cell cycle,Nucleus,Transcription,Transcription regulation, chain:Protein NPAT,domain:LisH, P70365 nuclear receptor coactivator 1(Ncoa1) Mus musculus m_PPARgPathway:Role of PPAR-gamma Coactivators in Obesity and Thermogenesis,m_rarrxrPathway:Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells,m_vdrPathway:Control of Gene Expression by Vitamin D Receptor, GO:0000435~positive regulation of transcription from RNA polymerase II promoter by galactose,GO:0002155~regulation of thyroid hormone mediated signaling pathway,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007595~lactation,GO:0008584~male gonad development,GO:0021549~cerebellum development,GO:0021766~hippocampus development,GO:0021854~hypothalamus development,GO:0021987~cerebral cortex development,GO:0032355~response to estradiol,GO:0032526~response to retinoic acid,GO:0032570~response to progesterone,GO:0032870~cellular response to hormone stimulus,GO:0043065~positive regulation of apoptotic process,GO:0043967~histone H4 acetylation,GO:0044849~estrous cycle,GO:0045666~positive regulation of neuron differentiation,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045925~positive regulation of female receptivity,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0060179~male mating behavior,GO:0060713~labyrinthine layer morphogenesis,GO:1904017~cellular response to Thyroglobulin triiodothyronine,GO:2001038~regulation of cellular response to drug,GO:2001141~regulation of RNA biosynthetic process, GO:0000790~nuclear chromatin,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0043005~neuron projection, GO:0001012~RNA polymerase II regulatory region DNA binding,GO:0003677~DNA binding,GO:0003682~chromatin binding,GO:0003713~transcription coactivator activity,GO:0004402~histone acetyltransferase activity,GO:0005515~protein binding,GO:0008134~transcription factor binding,GO:0016740~transferase activity,GO:0016746~transferase activity, transferring acyl groups,GO:0016922~ligand-dependent nuclear receptor binding,GO:0019899~enzyme binding,GO:0030331~estrogen receptor binding,GO:0030374~ligand-dependent nuclear receptor transcription coactivator activity,GO:0032403~protein complex binding,GO:0033142~progesterone receptor binding,GO:0035257~nuclear hormone receptor binding,GO:0042974~retinoic acid receptor binding,GO:0046965~retinoid X receptor binding,GO:0046983~protein dimerization activity,GO:0047485~protein N-terminus binding, IPR000014:PAS domain,IPR008955:Nuclear receptor coactivator Src-1,IPR009110:Nuclear receptor coactivator, interlocking,IPR010011:Domain of unknown function DUF1518,IPR011598:Myc-type, basic helix-loop-helix (bHLH) domain,IPR013767:PAS fold,IPR014920:Nuclear receptor coactivator, Ncoa-type, interlocking,IPR014935:Steroid receptor coactivator,IPR017426:Nuclear receptor coactivator, mmu04919:Thyroid hormone signaling pathway, SM00091:PAS,SM00353:HLH,SM01151:SM01151, 3D-structure,Acetylation,Activator,Acyltransferase,Alternative splicing,Complete proteome,Direct protein sequencing,Isopeptide bond,Methylation,Nucleus,Phosphoprotein,Reference proteome,Repeat,Transcription,Transcription regulation,Transferase,Ubl conjugation, chain:Nuclear receptor coactivator 1,compositionally biased region:Gln-rich,compositionally biased region:Ser-rich,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO),DNA-binding region:Basic motif,domain:Helix-loop-helix motif,domain:PAS,helix,modified residue,mutagenesis site,region of interest:Interaction with CREBBP,region of interest:Interaction with STAT3,sequence conflict,short sequence motif:LXXLL motif 1,short sequence motif:LXXLL motif 2,short sequence motif:LXXLL motif 3,short sequence motif:LXXLL motif 4,short sequence motif:LXXLL motif 5,short sequence motif:LXXLL motif 6,short sequence motif:LXXLL motif 7,splice variant,strand, Q8NI08 nuclear receptor coactivator 7(NCOA7) Homo sapiens GO:0006351~transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter, GO:0005622~intracellular,GO:0005634~nucleus, GO:0005515~protein binding,GO:0030374~ligand-dependent nuclear receptor transcription coactivator activity,GO:0035257~nuclear hormone receptor binding, IPR006571:TLDc,IPR018392:Peptidoglycan-binding lysin domain, SM00257:LysM,SM00584:TLDc, Acetylation,Activator,Alternative splicing,Coiled coil,Complete proteome,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Receptor,Reference proteome,Transcription,Transcription regulation, chain:Nuclear receptor coactivator 7,domain:TLD,modified residue,mutagenesis site,repeat:LysM,sequence conflict,sequence variant,splice variant, O42101 nuclear receptor subfamily 5, group A, member 2(NR5A2) Gallus gallus GO:0006351~transcription, DNA-templated,GO:0008206~bile acid metabolic process,GO:0009755~hormone-mediated signaling pathway,GO:0009888~tissue development,GO:0030522~intracellular receptor signaling pathway,GO:0030855~epithelial cell differentiation,GO:0042127~regulation of cell proliferation,GO:0042632~cholesterol homeostasis,GO:0043401~steroid hormone mediated signaling pathway,GO:0045070~positive regulation of viral genome replication,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0061113~pancreas morphogenesis, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0090575~RNA polymerase II transcription factor complex, GO:0000976~transcription regulatory region sequence-specific DNA binding,GO:0000978~RNA polymerase II core promoter proximal region sequence-specific DNA binding,GO:0000980~RNA polymerase II distal enhancer sequence-specific DNA binding,GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding,GO:0003682~chromatin binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0003707~steroid hormone receptor activity,GO:0004879~RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding,GO:0005543~phospholipid binding,GO:0008270~zinc ion binding,GO:0043565~sequence-specific DNA binding, IPR000536:Nuclear hormone receptor, ligand-binding, core,IPR001628:Zinc finger, nuclear hormone receptor-type,IPR001723:Steroid hormone receptor,IPR013088:Zinc finger, NHR/GATA-type,IPR016355:Steroidogenic factor 1, PIRSF002530:steroidogenic factor-like nuclear receptor, SM00399:ZnF_C4,SM00430:HOLI, Complete proteome,DNA-binding,Metal-binding,Nucleus,Receptor,Reference proteome,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Nuclear receptor subfamily 5 group A member 2,DNA-binding region:Nuclear receptor,region of interest:Ligand-binding,short sequence motif:FTZ-F1 box,zinc finger region:NR C4-type, Q6NU91 nucleolar complex associated 4 homolog L homeolog(noc4l.L) Xenopus laevis GO:0042254~ribosome biogenesis, GO:0005730~nucleolus,GO:0016021~integral component of membrane,GO:0031965~nuclear membrane, IPR005612:CCAAT-binding factor,IPR016024:Armadillo-type fold,IPR027193:Nucleolar complex protein 4, Membrane,Nucleus,Transmembrane,Transmembrane helix, chain:Nucleolar complex protein 4 homolog B,transmembrane region, Q6NRY2 nucleolar protein 6 L homeolog(nol6.L) Xenopus laevis GO:0005730~nucleolus, GO:0003723~RNA binding, IPR005554:Nrap protein, xla03008:Ribosome biogenesis in eukaryotes, Nucleus,RNA-binding, chain:Nucleolar protein 6, O75694 nucleoporin 155(NUP155) Homo sapiens GO:0000972~transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery,GO:0006405~RNA export from nucleus,GO:0006406~mRNA export from nucleus,GO:0006409~tRNA export from nucleus,GO:0006606~protein import into nucleus,GO:0006913~nucleocytoplasmic transport,GO:0006998~nuclear envelope organization,GO:0007077~mitotic nuclear envelope disassembly,GO:0010827~regulation of glucose transport,GO:0016032~viral process,GO:0016925~protein sumoylation,GO:0019083~viral transcription,GO:0031047~gene silencing by RNA,GO:0036228~protein targeting to nuclear inner membrane,GO:0075733~intracellular transport of virus,GO:0086014~atrial cardiac muscle cell action potential,GO:1900034~regulation of cellular response to heat, GO:0005635~nuclear envelope,GO:0005643~nuclear pore,GO:0016020~membrane,GO:0031965~nuclear membrane,GO:0044611~nuclear pore inner ring, GO:0005215~transporter activity,GO:0005515~protein binding,GO:0017056~structural constituent of nuclear pore, IPR004870:Nucleoporin, Nup155-like,IPR007187:Nucleoporin, Nup133/Nup155-like, C-terminal,IPR014908:Nucleoporin, Nup133/Nup155-like, N-terminal, hsa03013:RNA transport, 615770~Atrial fibrillation 15, 3D-structure,Alternative splicing,Atrial fibrillation,Coiled coil,Complete proteome,Disease mutation,Disulfide bond,Glycoprotein,Membrane,mRNA transport,Nuclear pore complex,Nucleus,Phosphoprotein,Protein transport,Proteomics identification,Reference proteome,Translocation,Transport, chain:Nuclear pore complex protein Nup155,compositionally biased region:Pro-rich,glycosylation site:O-linked (GlcNAc),modified residue,splice variant, Q4V8V2 nudix (nucleoside diphosphate linked moiety X)-type motif 17(nudt17) Danio rerio GO:0004787~thiamine-pyrophosphatase activity,GO:0008413~8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity,GO:0008758~UDP-2,3-diacylglucosamine hydrolase activity,GO:0008796~bis(5'-nucleosyl)-tetraphosphatase activity,GO:0008828~dATP pyrophosphohydrolase activity,GO:0016462~pyrophosphatase activity,GO:0016787~hydrolase activity,GO:0019176~dihydroneopterin monophosphate phosphatase activity,GO:0019177~dihydroneopterin triphosphate pyrophosphohydrolase activity,GO:0035870~dITP diphosphatase activity,GO:0036218~dTTP diphosphatase activity,GO:0036222~XTP diphosphatase activity,GO:0043141~ATP-dependent 5'-3' DNA helicase activity,GO:0044606~phosphocholine hydrolase activity,GO:0046872~metal ion binding, IPR000086:NUDIX hydrolase domain,IPR015797:NUDIX hydrolase domain-like, Complete proteome,Hydrolase,Magnesium,Manganese,Metal-binding,Proteomics identification,Reference proteome, chain:Nucleoside diphosphate-linked moiety X motif 17,domain:Nudix hydrolase,metal ion-binding site:Magnesium or manganese,short sequence motif:Nudix box, Q7T3C6 nudix hydrolase 21(nudt21) Danio rerio GO:0006378~mRNA polyadenylation,GO:0006397~mRNA processing, GO:0005634~nucleus,GO:0005849~mRNA cleavage factor complex,GO:0042382~paraspeckles, GO:0003723~RNA binding,GO:0003729~mRNA binding,GO:0016787~hydrolase activity,GO:0017091~AU-rich element binding, IPR000086:NUDIX hydrolase domain,IPR015797:NUDIX hydrolase domain-like,IPR016706:Cleavage/polyadenylation specificity factor subunit 5, dre03015:mRNA surveillance pathway, PIRSF017888:cleavage and polyadenylation specificity factor subunit 5, Complete proteome,mRNA processing,Nucleus,Reference proteome,RNA-binding, chain:Cleavage and polyadenylation specificity factor subunit 5,domain:Nudix hydrolase,short sequence motif:Nudix box, Q98892 opioid binding protein/cell adhesion molecule-like(OPCML) Gallus gallus GO:0007155~cell adhesion, GO:0005886~plasma membrane,GO:0031225~anchored component of membrane,GO:0070062~extracellular exosome, IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR007110:Immunoglobulin-like domain,IPR013098:Immunoglobulin I-set,IPR013783:Immunoglobulin-like fold, SM00408:IGc2,SM00409:IG, Cell adhesion,Cell membrane,Complete proteome,Direct protein sequencing,Disulfide bond,Glycoprotein,GPI-anchor,Immunoglobulin domain,Lipoprotein,Membrane,Reference proteome,Repeat,Signal, chain:Opioid-binding protein/cell adhesion molecule homolog,disulfide bond,domain:Ig-like C2-type 1,domain:Ig-like C2-type 2,domain:Ig-like C2-type 3,glycosylation site:N-linked (GlcNAc...),lipid moiety-binding region:GPI-anchor amidated asparagine,propeptide:Removed in mature form,signal peptide, P55814 ornithine decarboxylase antizyme 1 S homeolog(oaz1.S) Xenopus laevis GO:0006595~polyamine metabolic process,GO:0006596~polyamine biosynthetic process,GO:0090316~positive regulation of intracellular protein transport, GO:0005829~cytosol, GO:0008073~ornithine decarboxylase inhibitor activity, IPR002993:Ornithine decarboxylase antizyme,IPR016181:Acyl-CoA N-acyltransferase, Polyamine biosynthesis,Ribosomal frameshifting, chain:Ornithine decarboxylase antizyme, Q8CI95 oxysterol binding protein-like 11(Osbpl11) Mus musculus GO:0006810~transport,GO:0006869~lipid transport,GO:0010890~positive regulation of sequestering of triglyceride,GO:0045444~fat cell differentiation, GO:0005768~endosome,GO:0005794~Golgi apparatus,GO:0016020~membrane,GO:0031902~late endosome membrane, GO:0008289~lipid binding, IPR000648:Oxysterol-binding protein,IPR001849:Pleckstrin homology domain,IPR011993:Pleckstrin homology-like domain,IPR018494:Oxysterol-binding protein, conserved site, SM00233:PH, Acetylation,Complete proteome,Endosome,Golgi apparatus,Lipid transport,Lipid-binding,Membrane,Phosphoprotein,Proteomics identification,Reference proteome,Transport, chain:Oxysterol-binding protein-related protein 11,domain:PH,modified residue, B9EJ86 oxysterol binding protein-like 8(Osbpl8) Mus musculus GO:0006810~transport,GO:0006869~lipid transport,GO:0010891~negative regulation of sequestering of triglyceride,GO:0015914~phospholipid transport,GO:0030336~negative regulation of cell migration,GO:0032148~activation of protein kinase B activity,GO:0045444~fat cell differentiation,GO:0046628~positive regulation of insulin receptor signaling pathway,GO:0051897~positive regulation of protein kinase B signaling,GO:0090204~protein localization to nuclear pore,GO:2001275~positive regulation of glucose import in response to insulin stimulus, GO:0005634~nucleus,GO:0005783~endoplasmic reticulum,GO:0005789~endoplasmic reticulum membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0031965~nuclear membrane, GO:0001786~phosphatidylserine binding,GO:0005515~protein binding,GO:0005548~phospholipid transporter activity,GO:0008289~lipid binding,GO:0015485~cholesterol binding,GO:0070273~phosphatidylinositol-4-phosphate binding, IPR000648:Oxysterol-binding protein,IPR001849:Pleckstrin homology domain,IPR011993:Pleckstrin homology-like domain,IPR018494:Oxysterol-binding protein, conserved site, SM00233:PH, Acetylation,Complete proteome,Endoplasmic reticulum,Lipid transport,Lipid-binding,Membrane,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix,Transport, P91943 pangolin(pan) Drosophila melanogaster GO:0006355~regulation of transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0006366~transcription from RNA polymerase II promoter,GO:0007367~segment polarity determination,GO:0007435~salivary gland morphogenesis,GO:0007476~imaginal disc-derived wing morphogenesis,GO:0007500~mesodermal cell fate determination,GO:0007507~heart development,GO:0009880~embryonic pattern specification,GO:0010628~positive regulation of gene expression,GO:0016055~Wnt signaling pathway,GO:0030111~regulation of Wnt signaling pathway,GO:0030178~negative regulation of Wnt signaling pathway,GO:0035277~spiracle morphogenesis, open tracheal system,GO:0045610~regulation of hemocyte differentiation,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0060070~canonical Wnt signaling pathway,GO:0072091~regulation of stem cell proliferation, GO:0005634~nucleus,GO:0005667~transcription factor complex,GO:0005875~microtubule associated complex, GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding,GO:0003705~transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding,GO:0005515~protein binding,GO:0008013~beta-catenin binding,GO:0019900~kinase binding,GO:0043565~sequence-specific DNA binding,GO:0044212~transcription regulatory region DNA binding,GO:0070491~repressing transcription factor binding, IPR009071:High mobility group (HMG) box domain,IPR013558:CTNNB1 binding, N-teminal,IPR024940:Transcription factor TCF/LEF,IPR027397:Catenin binding domain, dme04310:Wnt signaling pathway, SM00398:HMG, Activator,Alternative splicing,Complete proteome,Developmental protein,DNA-binding,Nucleus,Reference proteome,Repressor,Segmentation polarity protein,Transcription,Transcription regulation,Wnt signaling pathway, chain:Protein pangolin, isoform J,chain:Protein pangolin, isoforms A/H/I,compositionally biased region:Poly-Asn,compositionally biased region:Poly-Lys,compositionally biased region:Poly-Ser,DNA-binding region:HMG box,region of interest:Beta-catenin binding site,short sequence motif:Nuclear localization signal,splice variant, Q96RV3 pecanex homolog 1 (Drosophila)(PCNX1) Homo sapiens GO:0016021~integral component of membrane, IPR007735:Pecanex, Alternative splicing,Complete proteome,Glycoprotein,Membrane,Polymorphism,Reference proteome,Transmembrane,Transmembrane helix, chain:Pecanex-like protein 1,compositionally biased region:Poly-His,compositionally biased region:Ser-rich,glycosylation site:N-linked (GlcNAc...),sequence conflict,sequence variant,splice variant,transmembrane region, O75439 peptidase, mitochondrial processing beta subunit(PMPCB) Homo sapiens General function prediction only, GO:0006122~mitochondrial electron transport, ubiquinol to cytochrome c,GO:0009060~aerobic respiration,GO:0016485~protein processing, GO:0005750~mitochondrial respiratory chain complex III,GO:0005759~mitochondrial matrix, GO:0003824~catalytic activity,GO:0004222~metalloendopeptidase activity,GO:0008270~zinc ion binding,GO:0046872~metal ion binding, IPR001431:Peptidase M16, zinc-binding site,IPR007863:Peptidase M16, C-terminal domain,IPR011237:Peptidase M16 domain,IPR011249:Metalloenzyme, LuxS/M16 peptidase-like,IPR011765:Peptidase M16, N-terminal, Complete proteome,Direct protein sequencing,Hydrolase,Metal-binding,Metalloprotease,Mitochondrion,Polymorphism,Protease,Proteomics identification,Reference proteome,Transit peptide,Zinc, active site:Proton acceptor,chain:Mitochondrial-processing peptidase subunit beta,metal ion-binding site:Zinc,sequence conflict,sequence variant,transit peptide:Mitochondrion, P08478 peptidylglycine alpha-amidating monooxygenase L homeolog(pam.L) Xenopus laevis Function unknown, GO:0006518~peptide metabolic process, GO:0016021~integral component of membrane,GO:0030658~transport vesicle membrane, GO:0004504~peptidylglycine monooxygenase activity,GO:0004598~peptidylamidoglycolate lyase activity,GO:0005507~copper ion binding, IPR000323:Copper type II, ascorbate-dependent monooxygenase, N-terminal,IPR000720:Peptidyl-glycine alpha-amidating monooxygenase,IPR001258:NHL repeat,IPR008977:PHM/PNGase F domain,IPR011042:Six-bladed beta-propeller, TolB-like,IPR013017:NHL repeat, subgroup,IPR014783:Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site,IPR014784:Copper type II, ascorbate-dependent monooxygenase-like, C-terminal,IPR020611:Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site, Alternative splicing,Copper,Cytoplasmic vesicle,Direct protein sequencing,Disulfide bond,Glycoprotein,Lyase,Membrane,Metal-binding,Monooxygenase,Multifunctional enzyme,Oxidoreductase,Repeat,Signal,Transmembrane,Transmembrane helix,Zinc, chain:Peptidyl-glycine alpha-amidating monooxygenase A,disulfide bond,glycosylation site:N-linked (GlcNAc...),metal ion-binding site:Copper A,metal ion-binding site:Copper B,region of interest:Peptidyl-alpha-hydroxyglycine alpha- amidating lyase,region of interest:Peptidylglycine alpha-hydroxylating monooxygenase,repeat:NHL 1,repeat:NHL 2,repeat:NHL 3,repeat:NHL 4,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Intragranular,transmembrane region, P14925 peptidylglycine alpha-amidating monooxygenase(Pam) Rattus norvegicus Function unknown, GO:0001519~peptide amidation,GO:0001666~response to hypoxia,GO:0001676~long-chain fatty acid metabolic process,GO:0006357~regulation of transcription from RNA polymerase II promoter,GO:0006518~peptide metabolic process,GO:0007417~central nervous system development,GO:0007507~heart development,GO:0007595~lactation,GO:0009268~response to pH,GO:0009404~toxin metabolic process,GO:0018032~protein amidation,GO:0019538~protein metabolic process,GO:0022602~ovulation cycle process,GO:0032355~response to estradiol,GO:0032956~regulation of actin cytoskeleton organization,GO:0042476~odontogenesis,GO:0042493~response to drug,GO:0046688~response to copper ion,GO:0050708~regulation of protein secretion,GO:0051260~protein homooligomerization,GO:0051384~response to glucocorticoid,GO:0055114~oxidation-reduction process,GO:0060135~maternal process involved in female pregnancy,GO:0060173~limb development, GO:0005615~extracellular space,GO:0005802~trans-Golgi network,GO:0005886~plasma membrane,GO:0009986~cell surface,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030141~secretory granule,GO:0030658~transport vesicle membrane,GO:0030667~secretory granule membrane,GO:0043005~neuron projection,GO:0043025~neuronal cell body,GO:0043204~perikaryon,GO:0048471~perinuclear region of cytoplasm,GO:0070062~extracellular exosome, GO:0004504~peptidylglycine monooxygenase activity,GO:0004598~peptidylamidoglycolate lyase activity,GO:0005507~copper ion binding,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0019901~protein kinase binding,GO:0031418~L-ascorbic acid binding, IPR000323:Copper type II, ascorbate-dependent monooxygenase, N-terminal,IPR000720:Peptidyl-glycine alpha-amidating monooxygenase,IPR001258:NHL repeat,IPR008977:PHM/PNGase F domain,IPR011042:Six-bladed beta-propeller, TolB-like,IPR013017:NHL repeat, subgroup,IPR014783:Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site,IPR014784:Copper type II, ascorbate-dependent monooxygenase-like, C-terminal,IPR020611:Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site, 3D-structure,Alternative splicing,Cleavage on pair of basic residues,Complete proteome,Copper,Cytoplasmic vesicle,Direct protein sequencing,Disulfide bond,Glycoprotein,Lyase,Membrane,Metal-binding,Monooxygenase,Multifunctional enzyme,Oxidoreductase,Phosphoprotein,Reference proteome,Repeat,Signal,Sulfation,Transmembrane,Transmembrane helix,Vitamin C,Zinc, chain:Peptidyl-glycine alpha-amidating monooxygenase,disulfide bond,glycosylation site:N-linked (GlcNAc...),helix,metal ion-binding site:Copper A,metal ion-binding site:Copper B,modified residue,region of interest:Interaction with RASSF9,region of interest:Peptidyl-alpha-hydroxyglycine alpha- amidating lyase,region of interest:Peptidylglycine alpha-hydroxylating monooxygenase,repeat:NHL 1,repeat:NHL 2,repeat:NHL 3,repeat:NHL 4,repeat:NHL 5,sequence conflict,signal peptide,splice variant,strand,topological domain:Cytoplasmic,topological domain:Intragranular,transmembrane region,turn, Q9D787 peptidylprolyl isomerase (cyclophilin)-like 2(Ppil2) Mus musculus GO:0000209~protein polyubiquitination,GO:0000413~protein peptidyl-prolyl isomerization,GO:0006457~protein folding,GO:0016567~protein ubiquitination,GO:0072659~protein localization to plasma membrane, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005886~plasma membrane, GO:0003755~peptidyl-prolyl cis-trans isomerase activity,GO:0004842~ubiquitin-protein transferase activity,GO:0016853~isomerase activity,GO:0016874~ligase activity,GO:0034450~ubiquitin-ubiquitin ligase activity,GO:0061630~ubiquitin protein ligase activity, IPR002130:Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain,IPR003613:U box domain,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR020892:Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site,IPR024936:Cyclophilin-type peptidyl-prolyl cis-trans isomerase, mmu04120:Ubiquitin mediated proteolysis, SM00504:Ubox, Acetylation,Coiled coil,Complete proteome,Isomerase,Ligase,Nucleus,Proteomics identification,Reference proteome,Rotamase,Ubl conjugation pathway, chain:Peptidyl-prolyl cis-trans isomerase-like 2,domain:PPIase cyclophilin-type,domain:U-box,modified residue,sequence conflict, O43447 peptidylprolyl isomerase H(PPIH) Homo sapiens GO:0000398~mRNA splicing, via spliceosome,GO:0000413~protein peptidyl-prolyl isomerization,GO:0006457~protein folding,GO:0006461~protein complex assembly,GO:0045070~positive regulation of viral genome replication, GO:0005654~nucleoplasm,GO:0005681~spliceosomal complex,GO:0005737~cytoplasm,GO:0016607~nuclear speck,GO:0046540~U4/U6 x U5 tri-snRNP complex,GO:0071001~U4/U6 snRNP, GO:0003755~peptidyl-prolyl cis-trans isomerase activity,GO:0005515~protein binding,GO:0016018~cyclosporin A binding,GO:0043021~ribonucleoprotein complex binding, IPR002130:Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain,IPR020892:Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site,IPR024936:Cyclophilin-type peptidyl-prolyl cis-trans isomerase, hsa03040:Spliceosome, PIRSF001467:peptidyl-prolyl cis-trans isomerase, 3D-structure,Acetylation,Alternative splicing,Chaperone,Complete proteome,Cytoplasm,Direct protein sequencing,Isomerase,mRNA processing,mRNA splicing,Nucleus,Proteomics identification,Reference proteome,Rotamase,Spliceosome, chain:Peptidyl-prolyl cis-trans isomerase H,domain:PPIase cyclophilin-type,helix,modified residue,mutagenesis site,strand,turn, O95613 pericentrin(PCNT) Homo sapiens h_akapcentrosomePathway:Protein Kinase A at the Centrosome, GO:0000086~G2/M transition of mitotic cell cycle,GO:0000226~microtubule cytoskeleton organization,GO:0007052~mitotic spindle organization,GO:0042384~cilium assembly,GO:0090316~positive regulation of intracellular protein transport, GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0005814~centriole,GO:0005829~cytosol,GO:0005874~microtubule,GO:0016020~membrane,GO:0034451~centriolar satellite, GO:0005515~protein binding,GO:0005516~calmodulin binding, IPR019528:Pericentrin/AKAP-450 centrosomal targeting domain,IPR024151:Pericentrin, 210720~Microcephalic osteodysplastic primordial dwarfism, type II, Alternative splicing,Calmodulin-binding,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Dwarfism,Microtubule,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:Pericentrin,compositionally biased region:Glu-rich,modified residue,mutagenesis site,region of interest:Calmodulin-binding,sequence conflict,sequence variant, Q96HA9 peroxisomal biogenesis factor 11 gamma(PEX11G) Homo sapiens GO:0016559~peroxisome fission,GO:0044375~regulation of peroxisome size, GO:0005777~peroxisome,GO:0005779~integral component of peroxisomal membrane,GO:0031231~intrinsic component of peroxisomal membrane,GO:0043234~protein complex, GO:0005515~protein binding, IPR008733:Peroxisomal biogenesis factor 11,IPR026510:Peroxisomal membrane protein 11C, metazoa, hsa04146:Peroxisome, Alternative splicing,Complete proteome,Membrane,Peroxisome,Polymorphism,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix, chain:Peroxisomal membrane protein 11C,sequence variant,splice variant,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, Q9D9M5 phosphatase, orphan 2(Phospho2) Mus musculus GO:0008152~metabolic process, GO:0016787~hydrolase activity,GO:0016791~phosphatase activity,GO:0033883~pyridoxal phosphatase activity,GO:0046872~metal ion binding, IPR006383:HAD-superfamily hydrolase, subfamily IB, PSPase-like,IPR006384:Pyridoxal phosphate phosphatase-related,IPR016965:Phosphatase PHOSPHO-type,IPR023214:HAD-like domain, mmu00750:Vitamin B6 metabolism,mmu01100:Metabolic pathways, PIRSF031051:pyridoxal phosphate phosphatase, PHOSPHO2 type, Complete proteome,Hydrolase,Magnesium,Metal-binding,Proteomics identification,Pyridoxal phosphate,Reference proteome, active site:Nucleophile,active site:Proton donor,binding site:Substrate,chain:Pyridoxal phosphate phosphatase PHOSPHO2,metal ion-binding site:Magnesium,sequence conflict, Q6AZN6 phosphatidylinositol 3-kinase catalytic subunit type 3 L homeolog(pik3c3.L) Xenopus laevis GO:0000910~cytokinesis,GO:0006914~autophagy,GO:0048015~phosphatidylinositol-mediated signaling, GO:0005622~intracellular,GO:0030496~midbody, GO:0005524~ATP binding,GO:0016303~1-phosphatidylinositol-3-kinase activity, IPR000008:C2 calcium-dependent membrane targeting,IPR000403:Phosphatidylinositol 3-/4-kinase, catalytic domain,IPR001263:Phosphoinositide 3-kinase, accessory (PIK) domain,IPR002420:Phosphatidylinositol 3-kinase C2 (PI3K C2) domain,IPR008290:Phosphatidylinositol 3-kinase, Vps34 type,IPR011009:Protein kinase-like domain,IPR015433:Phosphatidylinositol Kinase,IPR016024:Armadillo-type fold,IPR018936:Phosphatidylinositol 3/4-kinase, conserved site, xla00562:Inositol phosphate metabolism,xla01100:Metabolic pathways,xla04070:Phosphatidylinositol signaling system,xla04140:Regulation of autophagy,xla04145:Phagosome, PIRSF000587:phosphatidylinositol 3-kinase, Vps34 type, SM00142:PI3K_C2,SM00145:PI3Ka,SM00146:PI3Kc, ATP-binding,Autophagy,Cell cycle,Cell division,Kinase,Manganese,Nucleotide-binding,Transferase, chain:Phosphatidylinositol 3-kinase catalytic subunit type 3,domain:PI3K/PI4K, O08662 phosphatidylinositol 4-kinase alpha(Pi4ka) Rattus norvegicus GO:0046854~phosphatidylinositol phosphorylation,GO:0048015~phosphatidylinositol-mediated signaling,GO:0098609~cell-cell adhesion, GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0005913~cell-cell adherens junction,GO:0005925~focal adhesion,GO:0016020~membrane,GO:0030660~Golgi-associated vesicle membrane,GO:0070062~extracellular exosome, GO:0004430~1-phosphatidylinositol 4-kinase activity,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000403:Phosphatidylinositol 3-/4-kinase, catalytic domain,IPR001263:Phosphoinositide 3-kinase, accessory (PIK) domain,IPR011009:Protein kinase-like domain,IPR015433:Phosphatidylinositol Kinase,IPR016024:Armadillo-type fold,IPR018936:Phosphatidylinositol 3/4-kinase, conserved site, rno00562:Inositol phosphate metabolism,rno01100:Metabolic pathways,rno04070:Phosphatidylinositol signaling system, SM00145:PI3Ka,SM00146:PI3Kc, ATP-binding,Cell membrane,Complete proteome,Cytoplasm,Kinase,Membrane,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome,Transferase, Q969N2 phosphatidylinositol glycan anchor biosynthesis class T(PIGT) Homo sapiens GO:0016255~attachment of GPI anchor to protein,GO:0030182~neuron differentiation,GO:0051402~neuron apoptotic process, GO:0005789~endoplasmic reticulum membrane,GO:0016020~membrane,GO:0016023~cytoplasmic, membrane-bounded vesicle,GO:0030176~integral component of endoplasmic reticulum membrane,GO:0042765~GPI-anchor transamidase complex, GO:0003923~GPI-anchor transamidase activity,GO:0005515~protein binding, IPR007245:GPI transamidase component PIG-T, hsa00563:Glycosylphosphatidylinositol(GPI)-anchor biosynthesis,hsa01100:Metabolic pathways, 615398~Multiple congenital anomalies-hypotonia-seizures syndrome 3,615399~Paroxysmal nocturnal hemoglobinuria 2, Alternative splicing,Complete proteome,Direct protein sequencing,Disease mutation,Disulfide bond,Endoplasmic reticulum,Epilepsy,Glycoprotein,GPI-anchor biosynthesis,Membrane,Polymorphism,Proteomics identification,Reference proteome,Signal,Transmembrane,Transmembrane helix, chain:GPI transamidase component PIG-T,disulfide bond,glycosylation site:N-linked (GlcNAc...),mutagenesis site,sequence variant,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, D3ZSI8 phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha(Pip5k1a) Rattus norvegicus GO:0006661~phosphatidylinositol biosynthetic process,GO:0008654~phospholipid biosynthetic process,GO:0010761~fibroblast migration,GO:0031532~actin cytoskeleton reorganization,GO:0046488~phosphatidylinositol metabolic process,GO:0046854~phosphatidylinositol phosphorylation,GO:0048041~focal adhesion assembly,GO:0060326~cell chemotaxis,GO:0072661~protein targeting to plasma membrane,GO:0090630~activation of GTPase activity,GO:0097178~ruffle assembly, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005847~mRNA cleavage and polyadenylation specificity factor complex,GO:0005886~plasma membrane,GO:0005925~focal adhesion,GO:0016607~nuclear speck,GO:0030027~lamellipodium,GO:0032587~ruffle membrane, GO:0005524~ATP binding,GO:0016308~1-phosphatidylinositol-4-phosphate 5-kinase activity,GO:0019900~kinase binding, IPR002498:Phosphatidylinositol-4-phosphate 5-kinase, core,IPR023610:Phosphatidylinositol-4-phosphate 5-kinase,IPR027483:Phosphatidylinositol-4-phosphate 5-kinase, C-terminal,IPR027484:Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain, rno00562:Inositol phosphate metabolism,rno01100:Metabolic pathways,rno04070:Phosphatidylinositol signaling system,rno04144:Endocytosis,rno04666:Fc gamma R-mediated phagocytosis,rno04810:Regulation of actin cytoskeleton,rno05231:Choline metabolism in cancer, SM00330:PIPKc, ATP-binding,Cell membrane,Cell projection,Complete proteome,Cytoplasm,Isopeptide bond,Kinase,Membrane,Nucleotide-binding,Nucleus,Reference proteome,Transferase,Ubl conjugation, Q9R0I8 phosphatidylinositol-5-phosphate 4-kinase type 2 alpha(Pip4k2a) Rattus norvegicus GO:0010506~regulation of autophagy,GO:0035855~megakaryocyte development,GO:0046854~phosphatidylinositol phosphorylation,GO:2000786~positive regulation of autophagosome assembly, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005776~autophagosome,GO:0005886~plasma membrane, GO:0005524~ATP binding,GO:0016307~phosphatidylinositol phosphate kinase activity,GO:0016309~1-phosphatidylinositol-5-phosphate 4-kinase activity, IPR002498:Phosphatidylinositol-4-phosphate 5-kinase, core,IPR023610:Phosphatidylinositol-4-phosphate 5-kinase,IPR027483:Phosphatidylinositol-4-phosphate 5-kinase, C-terminal,IPR027484:Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain, rno00562:Inositol phosphate metabolism,rno04070:Phosphatidylinositol signaling system,rno04810:Regulation of actin cytoskeleton, SM00330:PIPKc, Acetylation,ATP-binding,Cell membrane,Complete proteome,Cytoplasm,Kinase,Membrane,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Transferase, chain:Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha,domain:PIPK,modified residue, O55057 phosphodiesterase 6D, cGMP-specific, rod, delta(Pde6d) Mus musculus GO:0007601~visual perception,GO:0007602~phototransduction,GO:0050896~response to stimulus, GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005856~cytoskeleton,GO:0016020~membrane,GO:0030659~cytoplasmic vesicle membrane,GO:0031410~cytoplasmic vesicle,GO:0042995~cell projection, GO:0004114~3',5'-cyclic-nucleotide phosphodiesterase activity,GO:0005095~GTPase inhibitor activity,GO:0005515~protein binding,GO:0017137~Rab GTPase binding,GO:0047555~3',5'-cyclic-GMP phosphodiesterase activity, IPR008015:GMP phosphodiesterase, delta subunit,IPR014756:Immunoglobulin E-set,IPR017287:Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit, mmu00230:Purine metabolism, PIRSF037825:retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, delta subunit, Cell projection,cGMP,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Cytoskeleton,Membrane,Proteomics identification,Reference proteome,Sensory transduction,Vision, chain:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, P47712 phospholipase A2 group IVA(PLA2G4A) Homo sapiens h_eicosanoidPathway:Eicosanoid Metabolism,h_fcer1Pathway:Fc Epsilon Receptor I Signaling in Mast Cells,h_p38mapkPathway:p38 MAPK Signaling Pathway ,h_sppaPathway:Aspirin Blocks Signaling Pathway Involved in Platelet Activation, GO:0006644~phospholipid metabolic process,GO:0006654~phosphatidic acid biosynthetic process,GO:0006663~platelet activating factor biosynthetic process,GO:0006690~icosanoid metabolic process,GO:0009395~phospholipid catabolic process,GO:0019369~arachidonic acid metabolic process,GO:0035965~cardiolipin acyl-chain remodeling,GO:0036148~phosphatidylglycerol acyl-chain remodeling,GO:0036149~phosphatidylinositol acyl-chain remodeling,GO:0036150~phosphatidylserine acyl-chain remodeling,GO:0036151~phosphatidylcholine acyl-chain remodeling,GO:0036152~phosphatidylethanolamine acyl-chain remodeling,GO:0042127~regulation of cell proliferation,GO:0046456~icosanoid biosynthetic process,GO:0050482~arachidonic acid secretion,GO:0071236~cellular response to antibiotic, GO:0005737~cytoplasm,GO:0005743~mitochondrial inner membrane,GO:0005789~endoplasmic reticulum membrane,GO:0005794~Golgi apparatus,GO:0005829~cytosol,GO:0016023~cytoplasmic, membrane-bounded vesicle,GO:0031410~cytoplasmic vesicle, GO:0004622~lysophospholipase activity,GO:0004623~phospholipase A2 activity,GO:0005509~calcium ion binding,GO:0005544~calcium-dependent phospholipid binding,GO:0008970~phosphatidylcholine 1-acylhydrolase activity,GO:0046872~metal ion binding,GO:0047498~calcium-dependent phospholipase A2 activity, IPR000008:C2 calcium-dependent membrane targeting,IPR002642:Lysophospholipase, catalytic domain,IPR016035:Acyl transferase/acyl hydrolase/lysophospholipase, hsa00564:Glycerophospholipid metabolism,hsa00565:Ether lipid metabolism,hsa00590:Arachidonic acid metabolism,hsa00591:Linoleic acid metabolism,hsa00592:alpha-Linolenic acid metabolism,hsa01100:Metabolic pathways,hsa04010:MAPK signaling pathway,hsa04014:Ras signaling pathway,hsa04270:Vascular smooth muscle contraction,hsa04370:VEGF signaling pathway,hsa04611:Platelet activation,hsa04664:Fc epsilon RI signaling pathway,hsa04724:Glutamatergic synapse,hsa04726:Serotonergic synapse,hsa04730:Long-term depression,hsa04750:Inflammatory mediator regulation of TRP channels,hsa04912:GnRH signaling pathway,hsa04913:Ovarian steroidogenesis,hsa04921:Oxytocin signaling pathway,hsa05231:Choline metabolism in cancer, Phospholipase A2, group IV A, deficiency of~Phospholipase A2, group IV A, deficiency of, SM00022:PLAc,SM00239:C2, 3D-structure,Calcium,Complete proteome,Cytoplasm,Cytoplasmic vesicle,Direct protein sequencing,Disease mutation,Hydrolase,Lipid degradation,Lipid metabolism,Metal-binding,Phosphoprotein,Polymorphism,Reference proteome, chain:Cytosolic phospholipase A2,domain:C2,domain:PLA2c,helix,modified residue,mutagenesis site,region of interest:Phospholipid binding,sequence variant,strand,turn, Q9NQ66 phospholipase C beta 1(PLCB1) Homo sapiens h_bArr-mapkPathway:Role of �-arrestins in the activation and targeting of MAP kinases,h_bArrestin-srcPathway:Roles of �-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling,h_bArrestinPathway:�-arrestins in GPCR Desensitization,h_ccr3Pathway:CCR3 signaling in Eosinophils,h_cdmacPathway:Cadmium induces DNA synthesis and proliferation in macrophages,h_ck1Pathway:Regulation of ck1/cdk5 by type 1 glutamate receptors,h_edg1Pathway:Phospholipids as signalling intermediaries,h_eicosanoidPathway:Eicosanoid Metabolism,h_fmlpPathway:fMLP induced chemokine gene expression in HMC-1 cells,h_myosinPathway:PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase,h_par1pathway:Thrombin signaling and protease-activated receptors,h_pkcPathway:Activation of PKC through G protein coupled receptor,h_plcPathway:Phospholipase C Signaling Pathway,h_sppaPathway:Aspirin Blocks Signaling Pathway Involved in Platelet Activation,h_tubbyPathway:G-Protein Signaling Through Tubby Proteins, GO:0000086~G2/M transition of mitotic cell cycle,GO:0007165~signal transduction,GO:0007213~G-protein coupled acetylcholine receptor signaling pathway,GO:0007215~glutamate receptor signaling pathway,GO:0007223~Wnt signaling pathway, calcium modulating pathway,GO:0007420~brain development,GO:0007613~memory,GO:0008277~regulation of G-protein coupled receptor protein signaling pathway,GO:0016042~lipid catabolic process,GO:0021987~cerebral cortex development,GO:0032735~positive regulation of interleukin-12 production,GO:0035556~intracellular signal transduction,GO:0035722~interleukin-12-mediated signaling pathway,GO:0035723~interleukin-15-mediated signaling pathway,GO:0040019~positive regulation of embryonic development,GO:0043547~positive regulation of GTPase activity,GO:0043647~inositol phosphate metabolic process,GO:0045444~fat cell differentiation,GO:0045663~positive regulation of myoblast differentiation,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated,GO:0046330~positive regulation of JNK cascade,GO:0046488~phosphatidylinositol metabolic process,GO:0048009~insulin-like growth factor receptor signaling pathway,GO:0048639~positive regulation of developmental growth,GO:0051726~regulation of cell cycle,GO:0060466~activation of meiosis involved in egg activation,GO:0070498~interleukin-1-mediated signaling pathway,GO:0080154~regulation of fertilization,GO:1900087~positive regulation of G1/S transition of mitotic cell cycle,GO:2000344~positive regulation of acrosome reaction,GO:2000438~negative regulation of monocyte extravasation,GO:2000560~positive regulation of CD24 biosynthetic process, GO:0000790~nuclear chromatin,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0016607~nuclear speck,GO:0031965~nuclear membrane,GO:0043209~myelin sheath,GO:0070062~extracellular exosome, GO:0004435~phosphatidylinositol phospholipase C activity,GO:0004871~signal transducer activity,GO:0005096~GTPase activator activity,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0005521~lamin binding,GO:0005546~phosphatidylinositol-4,5-bisphosphate binding,GO:0019899~enzyme binding,GO:0042803~protein homodimerization activity, IPR000008:C2 calcium-dependent membrane targeting,IPR000909:Phospholipase C, phosphatidylinositol-specific , X domain,IPR001192:Phosphoinositide phospholipase C,IPR001711:Phospholipase C, phosphatidylinositol-specific, Y domain,IPR009535:Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site,IPR011992:EF-hand-like domain,IPR011993:Pleckstrin homology-like domain,IPR014815:PLC-beta, C-terminal,IPR015359:Phospholipase C, phosphoinositol-specific, EF-hand-like,IPR016280:Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta,IPR017946:PLC-like phosphodiesterase, TIM beta/alpha-barrel domain, hsa00562:Inositol phosphate metabolism,hsa01100:Metabolic pathways,hsa04015:Rap1 signaling pathway,hsa04020:Calcium signaling pathway,hsa04022:cGMP-PKG signaling pathway,hsa04062:Chemokine signaling pathway,hsa04070:Phosphatidylinositol signaling system,hsa04071:Sphingolipid signaling pathway,hsa04261:Adrenergic signaling in cardiomyocytes,hsa04270:Vascular smooth muscle contraction,hsa04310:Wnt signaling pathway,hsa04540:Gap junction,hsa04611:Platelet activation,hsa04713:Circadian entrainment,hsa04720:Long-term potentiation,hsa04723:Retrograde endocannabinoid signaling,hsa04724:Glutamatergic synapse,hsa04725:Cholinergic synapse,hsa04726:Serotonergic synapse,hsa04728:Dopaminergic synapse,hsa04730:Long-term depression,hsa04750:Inflammatory mediator regulation of TRP channels,hsa04911:Insulin secretion,hsa04912:GnRH signaling pathway,hsa04915:Estrogen signaling pathway,hsa04916:Melanogenesis,hsa04918:Thyroid hormone synthesis,hsa04919:Thyroid hormone signaling pathway,hsa04921:Oxytocin signaling pathway,hsa04922:Glucagon signaling pathway,hsa04924:Renin secretion,hsa04925:Aldosterone synthesis and secretion,hsa04961:Endocrine and other factor-regulated calcium reabsorption,hsa04970:Salivary secretion,hsa04971:Gastric acid secretion,hsa04972:Pancreatic secretion,hsa05010:Alzheimer's disease,hsa05016:Huntington's disease,hsa05142:Chagas disease (American trypanosomiasis),hsa05143:African trypanosomiasis,hsa05146:Amoebiasis,hsa05200:Pathways in cancer, 613722~Epileptic encephalopathy, early infantile, 12, PIRSF000956:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta, SM00148:PLCXc,SM00149:PLCYc,SM00239:C2, Alternative splicing,Calcium,Coiled coil,Complete proteome,Cytoplasm,Epilepsy,Hydrolase,Lipid degradation,Lipid metabolism,Membrane,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transducer,TransducerFT SSSFLSETCHEDPSVSPNF, chain:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1,domain:C2,domain:PI-PLC X-box,domain:PI-PLC Y-box,modified residue,sequence conflict,sequence variant,splice variant, Q9Z1B3 phospholipase C, beta 1(Plcb1) Mus musculus :Role of �-arrestins in the activation and targeting of MAP kinases,m_bArrestin-srcPathway:Roles of �-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling,m_bArrestinPathway:�-arrestins in GPCR Desensitization,m_ccr3Pathway:CCR3 signaling in Eosinophils,m_cdmacPathway:Cadmium induces DNA synthesis and proliferation in macrophages,m_ck1Pathway:Regulation of ck1/cdk5 by type 1 glutamate receptors,m_edg1Pathway:Phospholipids as signalling intermediaries,m_eicosanoidPathway:Eicosanoid Metabolism,m_fmlpPathway:fMLP induced chemokine gene expression in HMC-1 cells,m_par1pathway:Thrombin signaling and protease-activated receptors,m_pkcPathway:Activation of PKC through G protein coupled receptor,m_plcPathway:Phospholipase C Signaling Pathway,m_tubbyPathway:G-Protein Signaling Through Tubby Proteins, GO:0000086~G2/M transition of mitotic cell cycle,GO:0001556~oocyte maturation,GO:0006397~mRNA processing,GO:0006629~lipid metabolic process,GO:0007155~cell adhesion,GO:0007165~signal transduction,GO:0007213~G-protein coupled acetylcholine receptor signaling pathway,GO:0007215~glutamate receptor signaling pathway,GO:0007420~brain development,GO:0007613~memory,GO:0008277~regulation of G-protein coupled receptor protein signaling pathway,GO:0008286~insulin receptor signaling pathway,GO:0016042~lipid catabolic process,GO:0021987~cerebral cortex development,GO:0030218~erythrocyte differentiation,GO:0030225~macrophage differentiation,GO:0031161~phosphatidylinositol catabolic process,GO:0032417~positive regulation of sodium:proton antiporter activity,GO:0032735~positive regulation of interleukin-12 production,GO:0032957~inositol trisphosphate metabolic process,GO:0034284~response to monosaccharide,GO:0035556~intracellular signal transduction,GO:0035722~interleukin-12-mediated signaling pathway,GO:0035723~interleukin-15-mediated signaling pathway,GO:0040019~positive regulation of embryonic development,GO:0043434~response to peptide hormone,GO:0045444~fat cell differentiation,GO:0045663~positive regulation of myoblast differentiation,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045893~positive regulation of transcription, DNA-templated,GO:0046330~positive regulation of JNK cascade,GO:0046488~phosphatidylinositol metabolic process,GO:0048009~insulin-like growth factor receptor signaling pathway,GO:0048639~positive regulation of developmental growth,GO:0050796~regulation of insulin secretion,GO:0051726~regulation of cell cycle,GO:0060466~activation of meiosis involved in egg activation,GO:0070498~interleukin-1-mediated signaling pathway,GO:0080154~regulation of fertilization,GO:1900087~positive regulation of G1/S transition of mitotic cell cycle,GO:2000344~positive regulation of acrosome reaction,GO:2000438~negative regulation of monocyte extravasation,GO:2000560~positive regulation of CD24 biosynthetic process, GO:0000790~nuclear chromatin,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016607~nuclear speck,GO:0031965~nuclear membrane,GO:0043209~myelin sheath,GO:0070062~extracellular exosome, GO:0004435~phosphatidylinositol phospholipase C activity,GO:0004871~signal transducer activity,GO:0005096~GTPase activator activity,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0005521~lamin binding,GO:0005546~phosphatidylinositol-4,5-bisphosphate binding,GO:0008081~phosphoric diester hydrolase activity,GO:0016787~hydrolase activity,GO:0019899~enzyme binding,GO:0042803~protein homodimerization activity, IPR000008:C2 calcium-dependent membrane targeting,IPR000909:Phospholipase C, phosphatidylinositol-specific , X domain,IPR001192:Phosphoinositide phospholipase C,IPR001711:Phospholipase C, phosphatidylinositol-specific, Y domain,IPR009535:Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site,IPR011992:EF-hand-like domain,IPR011993:Pleckstrin homology-like domain,IPR014815:PLC-beta, C-terminal,IPR015359:Phospholipase C, phosphoinositol-specific, EF-hand-like,IPR016280:Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta,IPR017946:PLC-like phosphodiesterase, TIM beta/alpha-barrel domain, mmu00562:Inositol phosphate metabolism,mmu01100:Metabolic pathways,mmu04015:Rap1 signaling pathway,mmu04020:Calcium signaling pathway,mmu04022:cGMP-PKG signaling pathway,mmu04062:Chemokine signaling pathway,mmu04070:Phosphatidylinositol signaling system,mmu04071:Sphingolipid signaling pathway,mmu04261:Adrenergic signaling in cardiomyocytes,mmu04270:Vascular smooth muscle contraction,mmu04310:Wnt signaling pathway,mmu04540:Gap junction,mmu04611:Platelet activation,mmu04713:Circadian entrainment,mmu04720:Long-term potentiation,mmu04723:Retrograde endocannabinoid signaling,mmu04724:Glutamatergic synapse,mmu04725:Cholinergic synapse,mmu04726:Serotonergic synapse,mmu04728:Dopaminergic synapse,mmu04730:Long-term depression,mmu04750:Inflammatory mediator regulation of TRP channels,mmu04911:Insulin secretion,mmu04912:GnRH signaling pathway,mmu04915:Estrogen signaling pathway,mmu04916:Melanogenesis,mmu04918:Thyroid hormone synthesis,mmu04919:Thyroid hormone signaling pathway,mmu04921:Oxytocin signaling pathway,mmu04922:Glucagon signaling pathway,mmu04924:Renin secretion,mmu04925:Aldosterone synthesis and secretion,mmu04961:Endocrine and other factor-regulated calcium reabsorption,mmu04970:Salivary secretion,mmu04971:Gastric acid secretion,mmu04972:Pancreatic secretion,mmu05010:Alzheimer's disease,mmu05016:Huntington's disease,mmu05142:Chagas disease (American trypanosomiasis),mmu05143:African trypanosomiasis,mmu05146:Amoebiasis,mmu05200:Pathways in cancer, PIRSF000956:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta, SM00148:PLCXc,SM00149:PLCYc,SM00239:C2, Alternative splicing,Calcium,Coiled coil,Complete proteome,Cytoplasm,Hydrolase,Lipid degradation,Lipid metabolism,Membrane,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Transducer,TransducerFT PSSVLSEGCHEDPSVPPNF, chain:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1,compositionally biased region:Lys-rich,domain:C2,domain:PI-PLC X-box,domain:PI-PLC Y-box,modified residue,sequence conflict,sequence variant,splice variant, Q5SUR0 phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)(Pfas) Mus musculus GO:0006164~purine nucleotide biosynthetic process,GO:0006189~'de novo' IMP biosynthetic process,GO:0006541~glutamine metabolic process,GO:0009156~ribonucleoside monophosphate biosynthetic process,GO:0042493~response to drug, GO:0005737~cytoplasm,GO:0070062~extracellular exosome, GO:0000166~nucleotide binding,GO:0004642~phosphoribosylformylglycinamidine synthase activity,GO:0005524~ATP binding,GO:0016874~ligase activity,GO:0046872~metal ion binding, IPR010073:Phosphoribosylformylglycinamidine synthase,IPR010918:AIR synthase-related protein, C-terminal domain,IPR016188:PurM, N-terminal-like,IPR017926:Glutamine amidotransferase, mmu00230:Purine metabolism,mmu01100:Metabolic pathways,mmu01130:Biosynthesis of antibiotics, ATP-binding,Complete proteome,Cytoplasm,Glutamine amidotransferase,Ligase,Magnesium,Metal-binding,Nucleotide-binding,Phosphoprotein,Proteomics identification,Purine biosynthesis,Reference proteome, active site:For GATase activity,chain:Phosphoribosylformylglycinamidine synthase,domain:Glutamine amidotransferase type-1,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict, Q8BWJ3 phosphorylase kinase alpha 2(Phka2) Mus musculus GO:0005975~carbohydrate metabolic process,GO:0005977~glycogen metabolic process, GO:0005886~plasma membrane,GO:0005964~phosphorylase kinase complex,GO:0016020~membrane, GO:0003824~catalytic activity,GO:0004689~phosphorylase kinase activity,GO:0005516~calmodulin binding, IPR008734:Phosphorylase kinase alpha/beta subunit,IPR008928:Six-hairpin glycosidase-like,IPR011613:Glycoside hydrolase family 15,IPR012341:Six-hairpin glycosidase, mmu04020:Calcium signaling pathway,mmu04910:Insulin signaling pathway,mmu04922:Glucagon signaling pathway, Calmodulin-binding,Carbohydrate metabolism,Cell membrane,Complete proteome,Glycogen metabolism,Lipoprotein,Membrane,Phosphoprotein,Prenylation,Proteomics identification,Reference proteome, chain:Phosphorylase b kinase regulatory subunit alpha, liver isoform,lipid moiety-binding region:S-farnesyl cysteine,modified residue,region of interest:Calmodulin-binding, Q92508 piezo type mechanosensitive ion channel component 1(PIEZO1) Homo sapiens GO:0006812~cation transport,GO:0033625~positive regulation of integrin activation,GO:0033634~positive regulation of cell-cell adhesion mediated by integrin,GO:0098655~cation transmembrane transport, GO:0005783~endoplasmic reticulum,GO:0005789~endoplasmic reticulum membrane,GO:0005886~plasma membrane,GO:0016021~integral component of membrane,GO:0031258~lamellipodium membrane,GO:0033116~endoplasmic reticulum-Golgi intermediate compartment membrane, GO:0005261~cation channel activity,GO:0008381~mechanically-gated ion channel activity, IPR027272:Piezo family, 194380~Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema, Cell membrane,Cell projection,Coiled coil,Complete proteome,Direct protein sequencing,Disease mutation,Disulfide bond,Endoplasmic reticulum,Glycoprotein,Hereditary hemolytic anemia,Ion channel,Ion transport,Membrane,Phosphoprotein,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix,Transport, chain:Protein FAM38A,glycosylation site:N-linked (GlcNAc...),modified residue,sequence conflict,transmembrane region, Q9Y2H5 pleckstrin homology domain containing A6(PLEKHA6) Homo sapiens IPR001849:Pleckstrin homology domain,IPR011993:Pleckstrin homology-like domain, SM00233:PH, 3D-structure,Coiled coil,Complete proteome,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:Pleckstrin homology domain-containing family A member 6,compositionally biased region:Pro-rich,domain:PH,helix,modified residue,sequence variant,strand,turn, Q00IB7 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1(plekhh1) Danio rerio Cell division and chromosome partitioning, GO:0001569~patterning of blood vessels,GO:0007275~multicellular organism development,GO:0007411~axon guidance,GO:0048514~blood vessel morphogenesis, GO:0005856~cytoskeleton, IPR000299:FERM domain,IPR000857:MyTH4 domain,IPR001849:Pleckstrin homology domain,IPR011993:Pleckstrin homology-like domain,IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle,IPR019748:FERM central domain,IPR019749:Band 4.1 domain, SM00139:MyTH4,SM00233:PH,SM00295:B41, Coiled coil,Complete proteome,Developmental protein,Reference proteome,Repeat, chain:Pleckstrin homology domain-containing family H member 1,compositionally biased region:Pro-rich,compositionally biased region:Ser-rich,domain:FERM,domain:MyTH4,domain:PH 1,domain:PH 2, Q8IVE3 pleckstrin homology, MyTH4 and FERM domain containing H2(PLEKHH2) Homo sapiens GO:0030835~negative regulation of actin filament depolymerization, GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005886~plasma membrane,GO:0030027~lamellipodium,GO:0030864~cortical actin cytoskeleton, GO:0003779~actin binding,GO:0005515~protein binding,GO:0042802~identical protein binding, IPR000299:FERM domain,IPR000857:MyTH4 domain,IPR001849:Pleckstrin homology domain,IPR011993:Pleckstrin homology-like domain,IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle,IPR019748:FERM central domain,IPR019749:Band 4.1 domain, SM00139:MyTH4,SM00233:PH,SM00295:B41, Alternative splicing,Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Membrane,Polymorphism,Proteomics identification,Reference proteome,Repeat, chain:Pleckstrin homology domain-containing family H member 2,compositionally biased region:Poly-Ser,compositionally biased region:Ser-rich,domain:FERM,domain:MyTH4,domain:PH 1,domain:PH 2,sequence conflict,sequence variant,splice variant,transmembrane region, Q8BZH4 pogo transposable element with ZNF domain(Pogz) Mus musculus GO:0007049~cell cycle,GO:0007064~mitotic sister chromatid cohesion,GO:0051301~cell division,GO:0051382~kinetochore assembly, GO:0000790~nuclear chromatin,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005694~chromosome,GO:0005737~cytoplasm, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0046872~metal ion binding, IPR004875:DDE superfamily endonuclease, CENP-B-like,IPR006600:HTH CenpB-type DNA-binding domain,IPR007087:Zinc finger, C2H2,IPR009057:Homeodomain-like,IPR015880:Zinc finger, C2H2-like, SM00355:ZnF_C2H2,SM00674:CENPB, Cell cycle,Cell division,Chromosome,Coiled coil,Complete proteome,Cytoplasm,DNA-binding,Metal-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Zinc,Zinc-finger, chain:Pogo transposable element with ZNF domain,compositionally biased region:Pro-rich,domain:DDE,domain:HTH CENPB-type,modified residue,sequence conflict,zinc finger region:C2H2-type 1; atypical,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, Q9BWT3 poly(A) polymerase gamma(PAPOLG) Homo sapiens GO:0006378~mRNA polyadenylation,GO:0031123~RNA 3'-end processing,GO:0043631~RNA polyadenylation, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0016020~membrane, GO:0003723~RNA binding,GO:0004652~polynucleotide adenylyltransferase activity,GO:0005524~ATP binding,GO:0046872~metal ion binding, IPR002934:Nucleotidyl transferase domain,IPR007010:Poly(A) polymerase, RNA-binding domain,IPR007012:Poly(A) polymerase, central domain,IPR011068:Nucleotidyltransferase, class I, C-terminal-like,IPR014492:Poly(A) polymerase, hsa03015:mRNA surveillance pathway, PIRSF018425:poly(A) polymerase, 3D-structure,Acetylation,Alternative splicing,ATP-binding,Complete proteome,Direct protein sequencing,Magnesium,Manganese,Metal-binding,mRNA processing,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,RNA-binding,Transferase, chain:Poly(A) polymerase gamma,modified residue,sequence conflict, O02776 poly(ADP-ribose) glycohydrolase(PARG) Bos taurus GO:0005975~carbohydrate metabolic process,GO:1990966~ATP generation from poly-ADP-D-ribose, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm, GO:0004649~poly(ADP-ribose) glycohydrolase activity, IPR007724:Poly(ADP-ribose) glycohydrolase, Acetylation,Complete proteome,Direct protein sequencing,Hydrolase,Nucleus,Phosphoprotein,Reference proteome, chain:Poly(ADP-ribose) glycohydrolase,modified residue,short sequence motif:Nuclear localization signal, Q9UKK3 poly(ADP-ribose) polymerase family member 4(PARP4) Homo sapiens GO:0006281~DNA repair,GO:0006464~cellular protein modification process,GO:0006471~protein ADP-ribosylation,GO:0006810~transport,GO:0006954~inflammatory response,GO:0006974~cellular response to DNA damage stimulus,GO:0008219~cell death,GO:0042493~response to drug, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005876~spindle microtubule,GO:0016020~membrane,GO:0030529~intracellular ribonucleoprotein complex,GO:0070062~extracellular exosome, GO:0003677~DNA binding,GO:0003950~NAD+ ADP-ribosyltransferase activity,GO:0005515~protein binding,GO:0019899~enzyme binding, IPR001357:BRCT domain,IPR002035:von Willebrand factor, type A,IPR004102:Poly(ADP-ribose) polymerase, regulatory domain,IPR012317:Poly(ADP-ribose) polymerase, catalytic domain,IPR013694:VIT domain, hsa03410:Base excision repair, SM00292:BRCT,SM00327:VWA,SM00609:VIT, Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Glycosyltransferase,Methylation,NAD,Nucleus,Phosphoprotein,Polymorphism,Reference proteome,Ribonucleoprotein,Transferase, chain:Poly [ADP-ribose] polymerase 4,domain:BRCT,domain:PARP alpha-helical,domain:PARP catalytic,domain:VIT,domain:VWFA,modified residue,region of interest:Interaction with the major vault protein,sequence conflict,sequence variant,short sequence motif:Nuclear localization signal, Q5RDU4 poly(ADP-ribose) polymerase family member 6(PARP6) Pongo abelii GO:0003950~NAD+ ADP-ribosyltransferase activity, IPR012317:Poly(ADP-ribose) polymerase, catalytic domain, Complete proteome,Glycosyltransferase,NAD,Reference proteome,Transferase, chain:Poly [ADP-ribose] polymerase 6,domain:PARP catalytic, Q86U86 polybromo 1(PBRM1) Homo sapiens Chromatin structure and dynamics / Transcription, GO:0006338~chromatin remodeling,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007067~mitotic nuclear division,GO:0008285~negative regulation of cell proliferation,GO:0016569~covalent chromatin modification, GO:0000228~nuclear chromosome,GO:0005654~nucleoplasm,GO:0090544~BAF-type complex, GO:0003677~DNA binding,GO:0003682~chromatin binding,GO:0005515~protein binding, IPR001025:Bromo adjacent homology (BAH) domain,IPR001487:Bromodomain,IPR009071:High mobility group (HMG) box domain,IPR018359:Bromodomain, conserved site, SM00297:BROMO,SM00398:HMG,SM00439:BAH, 3D-structure,Acetylation,Alternative splicing,Bromodomain,Chromatin regulator,Complete proteome,DNA-binding,Isopeptide bond,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,Tumor suppressor,Ubl conjugation, chain:Protein polybromo-1,compositionally biased region:Poly-Asp,compositionally biased region:Pro-rich,DNA-binding region:HMG box,domain:BAH 1,domain:BAH 2,domain:Bromo 1,domain:Bromo 2,domain:Bromo 3,domain:Bromo 4,domain:Bromo 5,domain:Bromo 6,helix,modified residue,sequence conflict,splice variant,turn, Q90941 polybromo 1(PBRM1) Gallus gallus Chromatin structure and dynamics / Transcription, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0008285~negative regulation of cell proliferation,GO:0016569~covalent chromatin modification, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0090544~BAF-type complex, GO:0003677~DNA binding,GO:0003682~chromatin binding, IPR001025:Bromo adjacent homology (BAH) domain,IPR001487:Bromodomain,IPR009071:High mobility group (HMG) box domain,IPR018359:Bromodomain, conserved site, SM00297:BROMO,SM00398:HMG,SM00439:BAH, 3D-structure,Bromodomain,Chromatin regulator,Coiled coil,Complete proteome,DNA-binding,Nucleus,Reference proteome,Repeat,Transcription,Transcription regulation, chain:Protein polybromo-1,compositionally biased region:Poly-Ala,compositionally biased region:Poly-Asp,compositionally biased region:Pro-rich,DNA-binding region:HMG box,domain:BAH 1,domain:BAH 2,domain:Bromo 1,domain:Bromo 2,domain:Bromo 3,domain:Bromo 4,domain:Bromo 5,domain:Bromo 6,helix,strand,turn, Q80ZA4 polycystic kidney and hepatic disease 1-like 1(Pkhd1l1) Mus musculus GO:0005929~cilium,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0005515~protein binding, IPR002909:Cell surface receptor IPT/TIG,IPR006626:Parallel beta-helix repeat,IPR008972:Cupredoxin,IPR011050:Pectin lyase fold/virulence factor,IPR011658:PA14,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR019316:G8 domain, SM00429:IPT,SM00710:PbH1,SM00758:PA14,SM01225:SM01225, Alternative splicing,Complete proteome,Glycoprotein,Membrane,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Fibrocystin-L,compositionally biased region:Ser-rich,domain:IPT/TIG 1,domain:IPT/TIG 10,domain:IPT/TIG 11,domain:IPT/TIG 12,domain:IPT/TIG 13,domain:IPT/TIG 14,domain:IPT/TIG 2,domain:IPT/TIG 3,domain:IPT/TIG 4,domain:IPT/TIG 5,domain:IPT/TIG 6,domain:IPT/TIG 7,domain:IPT/TIG 8,domain:IPT/TIG 9,glycosylation site:O-linked (GalNAc...),repeat:PbH1 1,repeat:PbH1 10,repeat:PbH1 2,repeat:PbH1 3,repeat:PbH1 4,repeat:PbH1 5,repeat:PbH1 6,repeat:PbH1 7,repeat:PbH1 8,repeat:PbH1 9,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, A2A559 post-GPI attachment to proteins 3(Pgap3) Mus musculus GO:0006505~GPI anchor metabolic process,GO:0006506~GPI anchor biosynthetic process, GO:0000139~Golgi membrane,GO:0005783~endoplasmic reticulum,GO:0005794~Golgi apparatus,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0031227~intrinsic component of endoplasmic reticulum membrane, GO:0016788~hydrolase activity, acting on ester bonds, IPR007217:Per1-like, Alternative splicing,Complete proteome,Endoplasmic reticulum,Glycoprotein,Golgi apparatus,GPI-anchor biosynthesis,Membrane,Reference proteome,Signal,Transmembrane,Transmembrane helix, chain:Post-GPI attachment to proteins factor 3,glycosylation site:N-linked (GlcNAc...),sequence conflict,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, Q5ZJP7 potassium channel tetramerization domain containing 7(KCTD7) Gallus gallus GO:0051260~protein homooligomerization, GO:0005829~cytosol,GO:0005886~plasma membrane, IPR000210:BTB/POZ-like,IPR003131:Potassium channel tetramerisation-type BTB domain,IPR011333:BTB/POZ fold, SM00225:BTB, Cell membrane,Complete proteome,Cytoplasm,Membrane,Reference proteome, chain:BTB/POZ domain-containing protein KCTD7,domain:BTB, Q8QFV0 potassium channel, subfamily T, member 1(KCNT1) Gallus gallus GO:0071805~potassium ion transmembrane transport, GO:0008076~voltage-gated potassium channel complex,GO:0016021~integral component of membrane, GO:0005249~voltage-gated potassium channel activity,GO:0015269~calcium-activated potassium channel activity, IPR003929:Potassium channel, calcium-activated, BK, alpha subunit,IPR013099:Ion transport 2,IPR016040:NAD(P)-binding domain, 3D-structure,Calcium,Cell membrane,Complete proteome,Glycoprotein,Ion channel,Ion transport,Membrane,Potassium,Potassium channel,Potassium transport,Reference proteome,Transmembrane,Transmembrane helix,Transport, chain:Potassium channel subfamily T member 1,domain:RCK N-terminal,glycosylation site:N-linked (GlcNAc...),region of interest:Pore-forming, in membrane,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q6UVM3 potassium sodium-activated channel subfamily T member 2(KCNT2) Homo sapiens GO:0071805~potassium ion transmembrane transport, GO:0008076~voltage-gated potassium channel complex,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0005249~voltage-gated potassium channel activity,GO:0005524~ATP binding,GO:0015269~calcium-activated potassium channel activity, IPR003929:Potassium channel, calcium-activated, BK, alpha subunit,IPR013099:Ion transport 2,IPR016040:NAD(P)-binding domain, Alternative splicing,ATP-binding,Cell membrane,Complete proteome,Glycoprotein,Ion channel,Ion transport,Membrane,Nucleotide-binding,Phosphoprotein,Polymorphism,Potassium,Potassium channel,Potassium transport,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix,Transport, chain:Potassium channel subfamily T member 2,domain:RCK N-terminal,glycosylation site:N-linked (GlcNAc...),nucleotide phosphate-binding region:ATP,region of interest:Pore-forming, in membrane,sequence variant,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q5ZJ85 pre-mRNA processing factor 3(PRPF3) Gallus gallus GO:0000244~spliceosomal tri-snRNP complex assembly,GO:0000398~mRNA splicing, via spliceosome, GO:0005634~nucleus,GO:0005681~spliceosomal complex,GO:0005737~cytoplasm,GO:0015030~Cajal body,GO:0016607~nuclear speck,GO:0046540~U4/U6 x U5 tri-snRNP complex, GO:0044822~poly(A) RNA binding, IPR002483:PWI domain,IPR010541:Domain of unknown function DUF1115,IPR013881:Pre-mRNA-splicing factor 3,IPR027104:U4/U6 small nuclear ribonucleoprotein Prp3, gga03040:Spliceosome, SM00311:PWI, Complete proteome,mRNA processing,mRNA splicing,Nucleus,Phosphoprotein,Reference proteome,Spliceosome, chain:U4/U6 small nuclear ribonucleoprotein PRP3,compositionally biased region:Poly-Val,domain:PWI, Q6P2Q9 pre-mRNA processing factor 8(PRPF8) Homo sapiens RNA processing and modification, GO:0000244~spliceosomal tri-snRNP complex assembly,GO:0000375~RNA splicing, via transesterification reactions,GO:0000398~mRNA splicing, via spliceosome,GO:0006397~mRNA processing,GO:0008380~RNA splicing,GO:0071222~cellular response to lipopolysaccharide,GO:0071356~cellular response to tumor necrosis factor, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005681~spliceosomal complex,GO:0005682~U5 snRNP,GO:0016020~membrane,GO:0016607~nuclear speck,GO:0071013~catalytic step 2 spliceosome, GO:0000386~second spliceosomal transesterification activity,GO:0003723~RNA binding,GO:0005515~protein binding,GO:0017070~U6 snRNA binding,GO:0030619~U1 snRNA binding,GO:0030620~U2 snRNA binding,GO:0030623~U5 snRNA binding,GO:0044822~poly(A) RNA binding,GO:0070530~K63-linked polyubiquitin binding,GO:0097157~pre-mRNA intronic binding, IPR000555:JAB1/Mov34/MPN/PAD-1,IPR012337:Ribonuclease H-like domain,IPR012591:Pre-mRNA-processing-splicing factor 8,IPR012592:PROCN,IPR012984:PRO, C-terminal,IPR019580:Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding,IPR019581:Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding,IPR019582:RNA recognition motif, spliceosomal PrP8,IPR021983:PRP8 domain IV core, hsa03040:Spliceosome, 600059~Retinitis pigmentosa 13, SM00232:JAB_MPN, 3D-structure,Acetylation,Complete proteome,Direct protein sequencing,Disease mutation,Methylation,mRNA processing,mRNA splicing,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Retinitis pigmentosa,Ribonucleoprotein,RNA-binding,Spliceosome, chain:Pre-mRNA-processing-splicing factor 8,domain:MPN,helix,modified residue,mutagenesis site,region of interest:Involved in interaction with pre-mRNA 5' splice site,region of interest:Required for interaction with EFTUD2 and SNRNP200,sequence conflict,sequence variant,strand,turn, Q7TSA6 proline and serine rich 3(Proser3) Mus musculus Alternative splicing,Complete proteome,Phosphoprotein,Reference proteome, chain:Uncharacterized protein C19orf55 homolog,compositionally biased region:Pro-rich,compositionally biased region:Ser-rich,splice variant, Q6PE13 proline-rich transmembrane protein 3(Prrt3) Mus musculus GO:0016020~membrane,GO:0016021~integral component of membrane, Complete proteome,Glycoprotein,Membrane,Methylation,Phosphoprotein,Proteomics identification,Reference proteome,Signal,Transmembrane,Transmembrane helix, chain:Proline-rich transmembrane protein 3,compositionally biased region:Pro-rich,glycosylation site:N-linked (GlcNAc...),modified residue,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, P97814 proline-serine-threonine phosphatase-interacting protein 1(Pstpip1) Mus musculus GO:0000910~cytokinesis,GO:0002376~immune system process,GO:0006897~endocytosis,GO:0006954~inflammatory response,GO:0007155~cell adhesion,GO:0016477~cell migration,GO:0045087~innate immune response, GO:0001725~stress fiber,GO:0001931~uropod,GO:0005737~cytoplasm,GO:0005826~actomyosin contractile ring,GO:0005856~cytoskeleton,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0030027~lamellipodium,GO:0032154~cleavage furrow,GO:0042995~cell projection,GO:0048471~perinuclear region of cytoplasm, GO:0003779~actin binding,GO:0005515~protein binding,GO:0019903~protein phosphatase binding, IPR001060:FCH domain,IPR001452:Src homology-3 domain,IPR013315:Spectrin alpha chain, SH3 domain, mmu04621:NOD-like receptor signaling pathway, SM00055:FCH,SM00326:SH3, Cell adhesion,Cell membrane,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Endocytosis,Immunity,Inflammatory response,Innate immunity,Membrane,Phosphoprotein,Proteomics identification,Reference proteome,SH3 domain, chain:Proline-serine-threonine phosphatase- interacting protein 1,domain:FCH,domain:SH3,modified residue,mutagenesis site,sequence conflict, Q99M15 proline-serine-threonine phosphatase-interacting protein 2(Pstpip2) Mus musculus GO:0007010~cytoskeleton organization,GO:0016477~cell migration, GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005856~cytoskeleton,GO:0016020~membrane, GO:0003779~actin binding,GO:0005515~protein binding, IPR001060:FCH domain, SM00055:FCH, Coiled coil,Complete proteome,Cytoplasm,Direct protein sequencing,Membrane,Phosphoprotein,Reference proteome, chain:Proline-serine-threonine phosphatase- interacting protein 2,domain:FCH,modified residue,sequence conflict, Q9W735 prominin 1a(prom1a) Danio rerio GO:0005783~endoplasmic reticulum,GO:0005793~endoplasmic reticulum-Golgi intermediate compartment,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0016324~apical plasma membrane,GO:0031528~microvillus membrane,GO:0042995~cell projection, IPR008795:Prominin, Cell membrane,Cell projection,Complete proteome,Endoplasmic reticulum,Glycoprotein,Membrane,Reference proteome,Signal,Transmembrane,Transmembrane helix, chain:Prominin-1-A,glycosylation site:N-linked (GlcNAc...),sequence conflict,transmembrane region, O02768 prostaglandin-endoperoxide synthase 2(PTGS2) Oryctolagus cuniculus GO:0001516~prostaglandin biosynthetic process,GO:0006954~inflammatory response,GO:0006979~response to oxidative stress,GO:0007566~embryo implantation,GO:0008217~regulation of blood pressure,GO:0019371~cyclooxygenase pathway,GO:0031622~positive regulation of fever generation,GO:0042127~regulation of cell proliferation,GO:0046697~decidualization,GO:0050873~brown fat cell differentiation,GO:0071456~cellular response to hypoxia,GO:0071498~cellular response to fluid shear stress,GO:0090336~positive regulation of brown fat cell differentiation, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005789~endoplasmic reticulum membrane,GO:0031090~organelle membrane,GO:0043005~neuron projection, GO:0004601~peroxidase activity,GO:0004666~prostaglandin-endoperoxide synthase activity,GO:0020037~heme binding,GO:0046872~metal ion binding,GO:0051213~dioxygenase activity, IPR000742:Epidermal growth factor-like domain,IPR010255:Haem peroxidase,IPR019791:Haem peroxidase, animal, subgroup, ocu00590:Arachidonic acid metabolism,ocu01100:Metabolic pathways,ocu04064:NF-kappa B signaling pathway,ocu04370:VEGF signaling pathway,ocu04668:TNF signaling pathway,ocu04723:Retrograde endocannabinoid signaling,ocu04726:Serotonergic synapse,ocu04913:Ovarian steroidogenesis,ocu04921:Oxytocin signaling pathway,ocu04923:Regulation of lipolysis in adipocytes,ocu05140:Leishmaniasis,ocu05200:Pathways in cancer,ocu05204:Chemical carcinogenesis,ocu05206:MicroRNAs in cancer,ocu05222:Small cell lung cancer, Complete proteome,Dioxygenase,Disulfide bond,Endoplasmic reticulum,Fatty acid biosynthesis,Fatty acid metabolism,Glycoprotein,Heme,Iron,Lipid biosynthesis,Lipid metabolism,Membrane,Metal-binding,Microsome,Oxidoreductase,Peroxidase,Prostaglandin biosynthesis,Prostaglandin metabolism,Reference proteome,S-nitrosylation,Signal, active site:For cyclooxygenase activity,active site:Proton acceptor,chain:Prostaglandin G/H synthase 2,disulfide bond,domain:EGF-like,glycosylation site:N-linked (GlcNAc...),metal ion-binding site:Iron (heme axial ligand),modified residue,signal peptide,site:Aspirin-acetylated serine, Q5ZK69 proteasomal ATPase associated factor 1(PAAF1) Gallus gallus GO:0000502~proteasome complex, IPR001680:WD40 repeat,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site, SM00320:WD40, Complete proteome,Proteasome,Reference proteome,Repeat,WD repeat, chain:Proteasomal ATPase-associated factor 1,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5, P35998 proteasome 26S subunit, ATPase 2(PSMC2) Homo sapiens Posttranslational modification, protein turnover, chaperones, GO:0000165~MAPK cascade,GO:0000209~protein polyubiquitination,GO:0001649~osteoblast differentiation,GO:0002223~stimulatory C-type lectin receptor signaling pathway,GO:0002479~antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent,GO:0006511~ubiquitin-dependent protein catabolic process,GO:0006521~regulation of cellular amino acid metabolic process,GO:0016032~viral process,GO:0030163~protein catabolic process,GO:0030433~ER-associated ubiquitin-dependent protein catabolic process,GO:0031145~anaphase-promoting complex-dependent catabolic process,GO:0033209~tumor necrosis factor-mediated signaling pathway,GO:0038061~NIK/NF-kappaB signaling,GO:0038095~Fc-epsilon receptor signaling pathway,GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process,GO:0043488~regulation of mRNA stability,GO:0045899~positive regulation of RNA polymerase II transcriptional preinitiation complex assembly,GO:0050852~T cell receptor signaling pathway,GO:0051436~negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,GO:0051437~positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition,GO:0060071~Wnt signaling pathway, planar cell polarity pathway,GO:0090090~negative regulation of canonical Wnt signaling pathway,GO:0090263~positive regulation of canonical Wnt signaling pathway,GO:1901800~positive regulation of proteasomal protein catabolic process, GO:0000502~proteasome complex,GO:0000932~cytoplasmic mRNA processing body,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0008540~proteasome regulatory particle, base subcomplex,GO:0016020~membrane,GO:0022624~proteasome accessory complex,GO:0031595~nuclear proteasome complex,GO:0031597~cytosolic proteasome complex,GO:0043231~intracellular membrane-bounded organelle, GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008233~peptidase activity,GO:0016787~hydrolase activity,GO:0016887~ATPase activity,GO:0017025~TBP-class protein binding,GO:0036402~proteasome-activating ATPase activity, IPR003593:AAA+ ATPase domain,IPR003959:ATPase, AAA-type, core,IPR003960:ATPase, AAA-type, conserved site,IPR005937:26S proteasome subunit P45,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa03050:Proteasome,hsa05169:Epstein-Barr virus infection, SM00382:AAA, 3D-structure,Acetylation,Alternative splicing,ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Direct protein sequencing,Host-virus interaction,Hydrolase,Nucleotide-binding,Nucleus,Protease,Proteasome,Proteomics identification,Reference proteome, chain:26S protease regulatory subunit 7,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict, Q5R5S4 proteasome 26S subunit, non-ATPase 1(PSMD1) Pongo abelii Posttranslational modification, protein turnover, chaperones, GO:0042176~regulation of protein catabolic process, GO:0016020~membrane,GO:0022624~proteasome accessory complex,GO:0070062~extracellular exosome, GO:0030234~enzyme regulator activity, IPR002015:Proteasome/cyclosome, regulatory subunit,IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold,IPR016642:26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit, pon03050:Proteasome,pon05169:Epstein-Barr virus infection, PIRSF015947:26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit, Acetylation,Complete proteome,Phosphoprotein,Proteasome,Reference proteome,Repeat, chain:26S proteasome non-ATPase regulatory subunit 1,compositionally biased region:Poly-Glu,modified residue,repeat:PC 1,repeat:PC 10,repeat:PC 2,repeat:PC 3,repeat:PC 4,repeat:PC 5,repeat:PC 6,repeat:PC 7,repeat:PC 8,repeat:PC 9, F1R2X6 proteasome activator subunit 4b(psme4b) Danio rerio GO:0006281~DNA repair,GO:0006974~cellular response to DNA damage stimulus,GO:0010499~proteasomal ubiquitin-independent protein catabolic process,GO:0035093~spermatogenesis, exchange of chromosomal proteins, GO:0000502~proteasome complex,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005839~proteasome core complex,GO:0016607~nuclear speck,GO:1990111~spermatoproteasome complex, GO:0016504~peptidase activator activity,GO:0070577~lysine-acetylated histone binding,GO:0070628~proteasome binding, IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold,IPR021843:Protein of unknown function DUF3437, dre03050:Proteasome, Coiled coil,Complete proteome,Cytoplasm,DNA damage,DNA repair,Nucleus,Proteasome,Proteomics identification,Reference proteome,Repeat, Q58DU5 proteasome subunit alpha 3(PSMA3) Bos taurus GO:0006511~ubiquitin-dependent protein catabolic process,GO:0052548~regulation of endopeptidase activity, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005839~proteasome core complex,GO:0019773~proteasome core complex, alpha-subunit complex,GO:0070062~extracellular exosome, GO:0004298~threonine-type endopeptidase activity, IPR000426:Proteasome, alpha-subunit, N-terminal domain,IPR001353:Proteasome, subunit alpha/beta,IPR023332:Proteasome A-type subunit, bta03050:Proteasome, SM00948:SM00948, 3D-structure,Acetylation,Complete proteome,Cytoplasm,Hydrolase,Nucleus,Phosphoprotein,Protease,Proteasome,Reference proteome,Threonine protease, chain:Proteasome subunit alpha type-3,helix,modified residue,strand, P62597 protection of telomeres 1(POT1) Gallus gallus GO:0000723~telomere maintenance,GO:0007004~telomere maintenance via telomerase,GO:0016233~telomere capping,GO:0032202~telomere assembly,GO:0032210~regulation of telomere maintenance via telomerase,GO:0032212~positive regulation of telomere maintenance via telomerase,GO:0032508~DNA duplex unwinding,GO:0051096~positive regulation of helicase activity,GO:0051973~positive regulation of telomerase activity,GO:0051974~negative regulation of telomerase activity,GO:0060383~positive regulation of DNA strand elongation,GO:0070200~establishment of protein localization to telomere, GO:0000781~chromosome, telomeric region,GO:0000783~nuclear telomere cap complex,GO:0005654~nucleoplasm,GO:0070187~telosome, GO:0010521~telomerase inhibitor activity,GO:0043047~single-stranded telomeric DNA binding,GO:0098505~G-rich strand telomeric DNA binding, IPR011564:Telomere end binding protein,IPR012340:Nucleic acid-binding, OB-fold, SM00976:SM00976, Chromosome,Complete proteome,DNA-binding,Nucleus,Reference proteome,Telomere, chain:Protection of telomeres protein 1, P13667 protein disulfide isomerase family A member 4(PDIA4) Homo sapiens GO:0006457~protein folding,GO:0009306~protein secretion,GO:0034976~response to endoplasmic reticulum stress,GO:0045454~cell redox homeostasis,GO:0061077~chaperone-mediated protein folding, GO:0005623~cell,GO:0005788~endoplasmic reticulum lumen,GO:0009986~cell surface,GO:0042470~melanosome, GO:0003756~protein disulfide isomerase activity,GO:0005515~protein binding,GO:0044822~poly(A) RNA binding, IPR005788:Disulphide isomerase,IPR005792:Protein disulphide isomerase,IPR012336:Thioredoxin-like fold,IPR013766:Thioredoxin domain,IPR017068:Protein disulphide-isomerase A4,IPR017937:Thioredoxin, conserved site, hsa04141:Protein processing in endoplasmic reticulum,hsa04918:Thyroid hormone synthesis,hsa05110:Vibrio cholerae infection, PIRSF036862:protein disulfide-isomerase A4, 3D-structure,Acetylation,Coiled coil,Complete proteome,Direct protein sequencing,Disulfide bond,Endoplasmic reticulum,Isomerase,Polymorphism,Proteomics identification,Redox-active center,Reference proteome,Repeat,Signal, chain:Protein disulfide-isomerase A4,compositionally biased region:Asp/Glu-rich (acidic),disulfide bond,domain:Thioredoxin 1,domain:Thioredoxin 2,domain:Thioredoxin 3,modified residue,sequence variant,short sequence motif:Prevents secretion from ER,signal peptide, Q5RJI4 protein kinase domain containing, cytoplasmic(Pkdcc) Mus musculus GO:0001501~skeletal system development,GO:0001503~ossification,GO:0006468~protein phosphorylation,GO:0006810~transport,GO:0007275~multicellular organism development,GO:0015031~protein transport,GO:0016310~phosphorylation,GO:0018108~peptidyl-tyrosine phosphorylation,GO:0030154~cell differentiation,GO:0030282~bone mineralization,GO:0030501~positive regulation of bone mineralization,GO:0032332~positive regulation of chondrocyte differentiation,GO:0035108~limb morphogenesis,GO:0035264~multicellular organism growth,GO:0042997~negative regulation of Golgi to plasma membrane protein transport,GO:0048286~lung alveolus development,GO:0048566~embryonic digestive tract development,GO:0060021~palate development, GO:0005576~extracellular region,GO:0005794~Golgi apparatus, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004713~protein tyrosine kinase activity,GO:0004715~non-membrane spanning protein tyrosine kinase activity,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0016740~transferase activity, IPR000719:Protein kinase, catalytic domain,IPR011009:Protein kinase-like domain,IPR022049:Uncharacterised protein family FAM69, Alternative splicing,ATP-binding,Complete proteome,Developmental protein,Differentiation,Glycoprotein,Golgi apparatus,Kinase,Nucleotide-binding,Osteogenesis,Phosphoprotein,Protein transport,Reference proteome,Secreted,Signal,Transferase,Transport,Tyrosine-protein kinase, chain:Protein kinase-like protein SgK493,domain:Protein kinase, Q96T49 protein phosphatase 1 regulatory subunit 16B(PPP1R16B) Homo sapiens GO:0001938~positive regulation of endothelial cell proliferation,GO:0014066~regulation of phosphatidylinositol 3-kinase signaling,GO:0035307~positive regulation of protein dephosphorylation,GO:0035308~negative regulation of protein dephosphorylation,GO:0050790~regulation of catalytic activity,GO:0051489~regulation of filopodium assembly,GO:0061028~establishment of endothelial barrier,GO:1902309~negative regulation of peptidyl-serine dephosphorylation,GO:1903589~positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, GO:0005634~nucleus,GO:0005886~plasma membrane,GO:0042995~cell projection,GO:0048471~perinuclear region of cytoplasm, GO:0005515~protein binding,GO:0008599~protein phosphatase type 1 regulator activity,GO:0019888~protein phosphatase regulator activity, IPR002110:Ankyrin repeat,IPR017417:Protein phosphatase 1, regulatory subunit 16A/B, eukaryote,IPR020683:Ankyrin repeat-containing domain, PIRSF038159:protein phosphatase 1, regulatory subunits 16A/B, vertebrate type, SM00248:ANK, Alternative splicing,ANK repeat,Cell membrane,Coiled coil,Complete proteome,Lipoprotein,Membrane,Methylation,Nucleus,Palmitate,Phosphoprotein,Prenylation,Reference proteome,Repeat, chain:Protein phosphatase 1 regulatory inhibitor subunit 16B,lipid moiety-binding region:S-farnesyl cysteine,repeat:ANK 1,repeat:ANK 2,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5, Q923M0 protein phosphatase 1, regulatory (inhibitor) subunit 16A(Ppp1r16a) Mus musculus GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0016020~membrane, GO:0008599~protein phosphatase type 1 regulator activity,GO:0019888~protein phosphatase regulator activity, IPR002110:Ankyrin repeat,IPR017417:Protein phosphatase 1, regulatory subunit 16A/B, eukaryote,IPR020683:Ankyrin repeat-containing domain, PIRSF038159:protein phosphatase 1, regulatory subunits 16A/B, vertebrate type, SM00248:ANK, ANK repeat,Cell membrane,Coiled coil,Complete proteome,Lipoprotein,Membrane,Methylation,Palmitate,Phosphoprotein,Prenylation,Proteomics identification,Reference proteome,Repeat, chain:Protein phosphatase 1 regulatory subunit 16A,lipid moiety-binding region:S-farnesyl cysteine,modified residue,repeat:ANK 1,repeat:ANK 2,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5, Q9JIG4 protein phosphatase 1, regulatory (inhibitor) subunit 3F(Ppp1r3f) Mus musculus GO:0005979~regulation of glycogen biosynthetic process,GO:2000465~regulation of glycogen (starch) synthase activity, GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0019903~protein phosphatase binding,GO:2001069~glycogen binding, IPR005036:Putative phosphatase regulatory subunit, mmu04910:Insulin signaling pathway, Alternative splicing,Complete proteome,Membrane,Phosphoprotein,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix, chain:Protein phosphatase 1 regulatory subunit 3F,domain:CBM21,glycosylation site:N-linked (GlcNAc...),sequence conflict,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q61074 protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform(Ppm1g) Mus musculus GO:0006470~protein dephosphorylation,GO:0007049~cell cycle,GO:0007050~cell cycle arrest,GO:0035970~peptidyl-threonine dephosphorylation, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0016020~membrane, GO:0003824~catalytic activity,GO:0004721~phosphoprotein phosphatase activity,GO:0004722~protein serine/threonine phosphatase activity,GO:0005515~protein binding,GO:0016787~hydrolase activity,GO:0043169~cation binding,GO:0046872~metal ion binding, IPR000222:Protein phosphatase 2C, manganese/magnesium aspartate binding site,IPR001932:Protein phosphatase 2C (PP2C)-like,IPR015655:Protein phosphatase 2C, SM00332:PP2Cc, Acetylation,Cell cycle,Complete proteome,Hydrolase,Lipoprotein,Magnesium,Manganese,Membrane,Metal-binding,Methylation,Myristate,Nucleus,Phosphoprotein,Protein phosphatase,Proteomics identification,Reference proteome,Repeat, chain:Protein phosphatase 1G,compositionally biased region:Asp/Glu-rich (acidic),metal ion-binding site:Manganese 1,metal ion-binding site:Manganese 1; via carbonyl oxygen,metal ion-binding site:Manganese 2,modified residue,sequence conflict, P62714 protein phosphatase 2 catalytic subunit beta(PPP2CB) Homo sapiens GO:0006470~protein dephosphorylation,GO:0008637~apoptotic mitochondrial changes,GO:0010468~regulation of gene expression,GO:0034976~response to endoplasmic reticulum stress,GO:0042542~response to hydrogen peroxide,GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process,GO:0046580~negative regulation of Ras protein signal transduction,GO:0046677~response to antibiotic, GO:0000159~protein phosphatase type 2A complex,GO:0000775~chromosome, centromeric region,GO:0000922~spindle pole,GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0070062~extracellular exosome, GO:0004721~phosphoprotein phosphatase activity,GO:0004722~protein serine/threonine phosphatase activity,GO:0005515~protein binding,GO:0008022~protein C-terminus binding,GO:0016787~hydrolase activity,GO:0046872~metal ion binding, IPR004843:Metallophosphoesterase domain,IPR006186:Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase, hsa03015:mRNA surveillance pathway,hsa04071:Sphingolipid signaling pathway,hsa04114:Oocyte meiosis,hsa04151:PI3K-Akt signaling pathway,hsa04152:AMPK signaling pathway,hsa04261:Adrenergic signaling in cardiomyocytes,hsa04350:TGF-beta signaling pathway,hsa04390:Hippo signaling pathway,hsa04530:Tight junction,hsa04728:Dopaminergic synapse,hsa04730:Long-term depression,hsa05142:Chagas disease (American trypanosomiasis),hsa05160:Hepatitis C, SM00156:PP2Ac, Centromere,Chromosome,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Hydrolase,Manganese,Metal-binding,Methylation,Nucleus,Phosphoprotein,Protein phosphatase,Proteomics identification,Reference proteome,Ubl conjugation, active site:Proton donor,chain:Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform,metal ion-binding site:Iron,metal ion-binding site:Manganese,modified residue,sequence conflict, Q76MZ3 protein phosphatase 2, regulatory subunit A, alpha(Ppp2r1a) Mus musculus GO:0006461~protein complex assembly,GO:0007059~chromosome segregation,GO:0007143~female meiotic division,GO:0051232~meiotic spindle elongation,GO:0051306~mitotic sister chromatid separation,GO:0051754~meiotic sister chromatid cohesion, centromeric,GO:0070262~peptidyl-serine dephosphorylation,GO:1903538~regulation of meiotic cell cycle process involved in oocyte maturation,GO:1904886~beta-catenin destruction complex disassembly,GO:2001241~positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, GO:0000159~protein phosphatase type 2A complex,GO:0000775~chromosome, centromeric region,GO:0005694~chromosome,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0070062~extracellular exosome, GO:0003823~antigen binding,GO:0004722~protein serine/threonine phosphatase activity,GO:0005515~protein binding,GO:0008601~protein phosphatase type 2A regulator activity,GO:0019888~protein phosphatase regulator activity,GO:0046982~protein heterodimerization activity, IPR000357:HEAT,IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold,IPR021133:HEAT, type 2, mmu03015:mRNA surveillance pathway,mmu04071:Sphingolipid signaling pathway,mmu04114:Oocyte meiosis,mmu04151:PI3K-Akt signaling pathway,mmu04152:AMPK signaling pathway,mmu04261:Adrenergic signaling in cardiomyocytes,mmu04350:TGF-beta signaling pathway,mmu04390:Hippo signaling pathway,mmu04530:Tight junction,mmu04728:Dopaminergic synapse,mmu04730:Long-term depression,mmu05142:Chagas disease (American trypanosomiasis),mmu05160:Hepatitis C, 3D-structure,Acetylation,Centromere,Chromosome,Chromosome partition,Complete proteome,Cytoplasm,Proteomics identification,Reference proteome,Repeat, chain:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform,helix,modified residue,repeat:HEAT 1,repeat:HEAT 10,repeat:HEAT 11,repeat:HEAT 12,repeat:HEAT 13,repeat:HEAT 14,repeat:HEAT 15,repeat:HEAT 2,repeat:HEAT 3,repeat:HEAT 4,repeat:HEAT 5,repeat:HEAT 6,repeat:HEAT 7,repeat:HEAT 8,repeat:HEAT 9,strand,turn, P63329 protein phosphatase 3 catalytic subunit alpha(Ppp3ca) Rattus norvegicus GO:0000082~G1/S transition of mitotic cell cycle,GO:0001975~response to amphetamine,GO:0006470~protein dephosphorylation,GO:0006606~protein import into nucleus,GO:0006816~calcium ion transport,GO:0010613~positive regulation of cardiac muscle hypertrophy,GO:0010628~positive regulation of gene expression,GO:0010629~negative regulation of gene expression,GO:0014883~transition between fast and slow fiber,GO:0014898~cardiac muscle hypertrophy in response to stress,GO:0016311~dephosphorylation,GO:0019722~calcium-mediated signaling,GO:0033173~calcineurin-NFAT signaling cascade,GO:0033555~multicellular organismal response to stress,GO:0035562~negative regulation of chromatin binding,GO:0035690~cellular response to drug,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0045955~negative regulation of calcium ion-dependent exocytosis,GO:0046676~negative regulation of insulin secretion,GO:0048741~skeletal muscle fiber development,GO:0050774~negative regulation of dendrite morphogenesis,GO:0050804~modulation of synaptic transmission,GO:0051091~positive regulation of sequence-specific DNA binding transcription factor activity,GO:0051533~positive regulation of NFAT protein import into nucleus,GO:0051592~response to calcium ion,GO:0060079~excitatory postsynaptic potential,GO:0071333~cellular response to glucose stimulus,GO:1903244~positive regulation of cardiac muscle hypertrophy in response to stress,GO:1903799~negative regulation of production of miRNAs involved in gene silencing by miRNA,GO:1905205~positive regulation of connective tissue replacement, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0005829~cytosol,GO:0005955~calcineurin complex,GO:0016020~membrane,GO:0030018~Z disc,GO:0042383~sarcolemma,GO:0098794~postsynapse, GO:0004721~phosphoprotein phosphatase activity,GO:0004722~protein serine/threonine phosphatase activity,GO:0004723~calcium-dependent protein serine/threonine phosphatase activity,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0008144~drug binding,GO:0019899~enzyme binding,GO:0033192~calmodulin-dependent protein phosphatase activity,GO:0046872~metal ion binding,GO:0046982~protein heterodimerization activity,GO:0046983~protein dimerization activity, IPR004843:Metallophosphoesterase domain,IPR006186:Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase, rno04010:MAPK signaling pathway,rno04020:Calcium signaling pathway,rno04022:cGMP-PKG signaling pathway,rno04114:Oocyte meiosis,rno04310:Wnt signaling pathway,rno04360:Axon guidance,rno04370:VEGF signaling pathway,rno04380:Osteoclast differentiation,rno04650:Natural killer cell mediated cytotoxicity,rno04660:T cell receptor signaling pathway,rno04662:B cell receptor signaling pathway,rno04720:Long-term potentiation,rno04724:Glutamatergic synapse,rno04728:Dopaminergic synapse,rno04921:Oxytocin signaling pathway,rno04922:Glucagon signaling pathway,rno04924:Renin secretion,rno05010:Alzheimer's disease,rno05014:Amyotrophic lateral sclerosis (ALS),rno05031:Amphetamine addiction,rno05152:Tuberculosis,rno05166:HTLV-I infection, SM00156:PP2Ac, 3D-structure,Acetylation,Alternative splicing,Calmodulin-binding,Cell membrane,Complete proteome,Direct protein sequencing,Hydrolase,Iron,Membrane,Metal-binding,Nitration,Nucleus,Phosphoprotein,Protein phosphatase,Reference proteome,Zinc, active site:Proton donor,chain:Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform,metal ion-binding site:Iron,metal ion-binding site:Zinc,modified residue,region of interest:Calcineurin B binding-site 1,region of interest:Calcineurin B binding-site 2,region of interest:Calmodulin-binding,region of interest:Catalytic,region of interest:Inhibitory domain,splice variant, Q7Z6K3 protein prenyltransferase alpha subunit repeat containing 1(PTAR1) Homo sapiens Posttranslational modification, protein turnover, chaperones, GO:0018342~protein prenylation, GO:0005737~cytoplasm,GO:1990234~transferase complex, GO:0008318~protein prenyltransferase activity, IPR002088:Protein prenyltransferase, alpha subunit, Acetylation,Complete proteome,Prenyltransferase,Proteomics identification,Reference proteome,Repeat,Transferase, chain:Protein prenyltransferase alpha subunit repeat-containing protein 1,repeat:PFTA 1,repeat:PFTA 2,repeat:PFTA 3,repeat:PFTA 4,repeat:PFTA 5, P29074 protein tyrosine phosphatase, non-receptor type 4(PTPN4) Homo sapiens GO:0006470~protein dephosphorylation,GO:0035335~peptidyl-tyrosine dephosphorylation, GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0009898~cytoplasmic side of plasma membrane,GO:0019898~extrinsic component of membrane, GO:0004725~protein tyrosine phosphatase activity,GO:0004726~non-membrane spanning protein tyrosine phosphatase activity,GO:0005515~protein binding,GO:0008092~cytoskeletal protein binding, IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type,IPR000299:FERM domain,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR000798:Ezrin/radixin/moesin like,IPR001478:PDZ domain,IPR003595:Protein-tyrosine phosphatase, catalytic,IPR011993:Pleckstrin homology-like domain,IPR012151:Protein-tyrosine phosphatase, non-receptor type-3, -4,IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle,IPR014847:FERM adjacent (FA),IPR016130:Protein-tyrosine phosphatase, active site,IPR018979:FERM, N-terminal,IPR018980:FERM, C-terminal PH-like domain,IPR019747:FERM conserved site,IPR019748:FERM central domain,IPR019749:Band 4.1 domain, PIRSF000927:non-receptor tyrosine-protein phosphatase, 3/4 types, SM00194:PTPc,SM00228:PDZ,SM00295:B41,SM00404:PTPc_motif,SM01195:SM01195,SM01196:SM01196, 3D-structure,Cell membrane,Complete proteome,Cytoplasm,Cytoskeleton,Hydrolase,Membrane,Phosphoprotein,Polymorphism,Protein phosphatase,Proteomics identification,Receptor,Reference proteome, active site:Phosphocysteine intermediate,chain:Tyrosine-protein phosphatase non-receptor type 4,domain:FERM,domain:PDZ,domain:Tyrosine-protein phosphatase,helix,sequence conflict,sequence variant,strand,turn, Q641Z2 protein tyrosine phosphatase, non-receptor type 9(Ptpn9) Rattus norvegicus GO:0035335~peptidyl-tyrosine dephosphorylation, GO:0005737~cytoplasm, GO:0004725~protein tyrosine phosphatase activity, IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR001251:CRAL-TRIO domain,IPR003595:Protein-tyrosine phosphatase, catalytic,IPR011074:CRAL/TRIO, N-terminal domain,IPR016130:Protein-tyrosine phosphatase, active site, SM00194:PTPc,SM00404:PTPc_motif,SM00516:SEC14, Acetylation,Complete proteome,Cytoplasm,Hydrolase,Protein phosphatase,Proteomics identification,Reference proteome, active site:Phosphocysteine intermediate,chain:Tyrosine-protein phosphatase non-receptor type 9,domain:CRAL-TRIO,domain:Tyrosine-protein phosphatase,modified residue, P18433 protein tyrosine phosphatase, receptor type A(PTPRA) Homo sapiens h_srcRPTPPathway:Activation of Src by Protein-tyrosine phosphatase alpha, GO:0000165~MAPK cascade,GO:0007411~axon guidance,GO:0008286~insulin receptor signaling pathway,GO:0035335~peptidyl-tyrosine dephosphorylation,GO:0043547~positive regulation of GTPase activity, GO:0005622~intracellular,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane,GO:0043235~receptor complex,GO:0070062~extracellular exosome, GO:0004725~protein tyrosine phosphatase activity,GO:0005001~transmembrane receptor protein tyrosine phosphatase activity,GO:0005088~Ras guanyl-nucleotide exchange factor activity,GO:0005515~protein binding, IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR003595:Protein-tyrosine phosphatase, catalytic,IPR016130:Protein-tyrosine phosphatase, active site,IPR016336:Receptor tyrosine-protein phosphatase, alpha/epsilon-type,IPR027262:Receptor tyrosine-protein phosphatase alpha, PIRSF002006:receptor tyrosine-protein phosphatase, alpha/epsilon types,PIRSF500808:receptor tyrosine-protein phosphatase alpha [Parent=PIRSF002006], SM00194:PTPc,SM00404:PTPc_motif, Alternative splicing,Complete proteome,Glycoprotein,Hydrolase,Membrane,Phosphoprotein,Polymorphism,Protein phosphatase,Proteomics identification,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, active site:Phosphocysteine intermediate,chain:Receptor-type tyrosine-protein phosphatase alpha,domain:Tyrosine-protein phosphatase 1,domain:Tyrosine-protein phosphatase 2,glycosylation site:N-linked (GlcNAc...),modified residue,sequence conflict,sequence variant,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, P10586 protein tyrosine phosphatase, receptor type F(PTPRF) Homo sapiens GO:0007155~cell adhesion,GO:0007185~transmembrane receptor protein tyrosine phosphatase signaling pathway,GO:0007268~chemical synaptic transmission,GO:0016477~cell migration,GO:0031102~neuron projection regeneration,GO:0035335~peptidyl-tyrosine dephosphorylation,GO:0048679~regulation of axon regeneration,GO:1900121~negative regulation of receptor binding, GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane,GO:0043005~neuron projection,GO:0043025~neuronal cell body,GO:0070062~extracellular exosome, GO:0004725~protein tyrosine phosphatase activity,GO:0005001~transmembrane receptor protein tyrosine phosphatase activity,GO:0008201~heparin binding,GO:0032403~protein complex binding,GO:0035373~chondroitin sulfate proteoglycan binding, IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR003595:Protein-tyrosine phosphatase, catalytic,IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR003961:Fibronectin, type III,IPR007110:Immunoglobulin-like domain,IPR013098:Immunoglobulin I-set,IPR013783:Immunoglobulin-like fold,IPR016130:Protein-tyrosine phosphatase, active site, hsa04514:Cell adhesion molecules (CAMs),hsa04520:Adherens junction,hsa04910:Insulin signaling pathway,hsa04931:Insulin resistance, 616001~Breasts and/or nipples, aplasia or hypoplasia of, 2, SM00060:FN3,SM00194:PTPc,SM00404:PTPc_motif,SM00408:IGc2,SM00409:IG, 3D-structure,Alternative splicing,Cell adhesion,Complete proteome,Disulfide bond,Glycoprotein,Heparin-binding,Hydrolase,Immunoglobulin domain,Membrane,Phosphoprotein,Polymorphism,Protein phosphatase,Proteomics identification,Receptor,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, active site:Phosphocysteine intermediate,chain:Receptor-type tyrosine-protein phosphatase F,disulfide bond,domain:Fibronectin type-III 1,domain:Fibronectin type-III 2,domain:Fibronectin type-III 3,domain:Fibronectin type-III 4,domain:Fibronectin type-III 5,domain:Fibronectin type-III 6,domain:Fibronectin type-III 7,domain:Fibronectin type-III 8,domain:Ig-like C2-type 1,domain:Ig-like C2-type 2,domain:Ig-like C2-type 3,domain:Tyrosine-protein phosphatase 1,domain:Tyrosine-protein phosphatase 2,glycosylation site:N-linked (GlcNAc...),helix,mutagenesis site,sequence conflict,sequence variant,signal peptide,splice variant,strand,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region,turn, Q15262 protein tyrosine phosphatase, receptor type K(PTPRK) Homo sapiens GO:0006470~protein dephosphorylation,GO:0007155~cell adhesion,GO:0007165~signal transduction,GO:0007179~transforming growth factor beta receptor signaling pathway,GO:0008285~negative regulation of cell proliferation,GO:0010839~negative regulation of keratinocyte proliferation,GO:0016477~cell migration,GO:0030336~negative regulation of cell migration,GO:0031175~neuron projection development,GO:0034394~protein localization to cell surface,GO:0034614~cellular response to reactive oxygen species,GO:0034644~cellular response to UV,GO:0035335~peptidyl-tyrosine dephosphorylation,GO:0045786~negative regulation of cell cycle,GO:0045892~negative regulation of transcription, DNA-templated,GO:0048041~focal adhesion assembly, GO:0001750~photoreceptor outer segment,GO:0005887~integral component of plasma membrane,GO:0005911~cell-cell junction,GO:0005912~adherens junction,GO:0009986~cell surface,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030424~axon,GO:0030425~dendrite,GO:0031256~leading edge membrane,GO:0043025~neuronal cell body, GO:0004725~protein tyrosine phosphatase activity,GO:0005001~transmembrane receptor protein tyrosine phosphatase activity,GO:0005515~protein binding,GO:0008013~beta-catenin binding,GO:0019901~protein kinase binding,GO:0045295~gamma-catenin binding, IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR000998:MAM domain,IPR003595:Protein-tyrosine phosphatase, catalytic,IPR003599:Immunoglobulin subtype,IPR003961:Fibronectin, type III,IPR007110:Immunoglobulin-like domain,IPR013098:Immunoglobulin I-set,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR013783:Immunoglobulin-like fold,IPR016130:Protein-tyrosine phosphatase, active site, SM00060:FN3,SM00137:MAM,SM00194:PTPc,SM00404:PTPc_motif,SM00409:IG, 3D-structure,Alternative splicing,Cell junction,Cell membrane,Complete proteome,Disulfide bond,Glycoprotein,Hydrolase,Immunoglobulin domain,Membrane,Phosphoprotein,Protein phosphatase,Proteomics identification,Receptor,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, active site:Phosphocysteine intermediate,chain:Receptor-type tyrosine-protein phosphatase kappa,disulfide bond,domain:Fibronectin type-III 1,domain:Fibronectin type-III 2,domain:Fibronectin type-III 3,domain:Fibronectin type-III 4,domain:Ig-like C2-type,domain:MAM,domain:Tyrosine-protein phosphatase 1,domain:Tyrosine-protein phosphatase 2,glycosylation site:N-linked (GlcNAc...),helix,modified residue,sequence conflict,signal peptide,site:Cleavage,splice variant,strand,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region,turn, P28827 protein tyrosine phosphatase, receptor type M(PTPRM) Homo sapiens GO:0001937~negative regulation of endothelial cell proliferation,GO:0006470~protein dephosphorylation,GO:0007156~homophilic cell adhesion via plasma membrane adhesion molecules,GO:0007165~signal transduction,GO:0010596~negative regulation of endothelial cell migration,GO:0010842~retina layer formation,GO:0016525~negative regulation of angiogenesis,GO:0031175~neuron projection development,GO:0031290~retinal ganglion cell axon guidance,GO:0035335~peptidyl-tyrosine dephosphorylation,GO:0042493~response to drug,GO:0045909~positive regulation of vasodilation, GO:0005737~cytoplasm,GO:0005887~integral component of plasma membrane,GO:0005911~cell-cell junction,GO:0005913~cell-cell adherens junction,GO:0016021~integral component of membrane,GO:0030027~lamellipodium,GO:0048471~perinuclear region of cytoplasm, GO:0004725~protein tyrosine phosphatase activity,GO:0005001~transmembrane receptor protein tyrosine phosphatase activity,GO:0005515~protein binding,GO:0042802~identical protein binding,GO:0045296~cadherin binding, IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR000998:MAM domain,IPR003595:Protein-tyrosine phosphatase, catalytic,IPR003599:Immunoglobulin subtype,IPR003961:Fibronectin, type III,IPR007110:Immunoglobulin-like domain,IPR013151:Immunoglobulin,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR013783:Immunoglobulin-like fold,IPR016130:Protein-tyrosine phosphatase, active site, hsa04514:Cell adhesion molecules (CAMs),hsa04520:Adherens junction, SM00060:FN3,SM00137:MAM,SM00194:PTPc,SM00404:PTPc_motif,SM00409:IG, 3D-structure,Alternative splicing,Cell adhesion,Complete proteome,Disulfide bond,Glycoprotein,Hydrolase,Immunoglobulin domain,Membrane,Phosphoprotein,Polymorphism,Protein phosphatase,Proteomics identification,Receptor,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, active site:Phosphocysteine intermediate,chain:Receptor-type tyrosine-protein phosphatase mu,disulfide bond,domain:Fibronectin type-III 1,domain:Fibronectin type-III 2,domain:Fibronectin type-III 3,domain:Fibronectin type-III 4,domain:Ig-like C2-type,domain:MAM,domain:Tyrosine-protein phosphatase 1,domain:Tyrosine-protein phosphatase 2,glycosylation site:N-linked (GlcNAc...),helix,modified residue,sequence conflict,sequence variant,signal peptide,strand,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region,turn, Q92932 protein tyrosine phosphatase, receptor type N2(PTPRN2) Homo sapiens GO:0006470~protein dephosphorylation,GO:0006629~lipid metabolic process,GO:0007269~neurotransmitter secretion,GO:0034260~negative regulation of GTPase activity,GO:0035335~peptidyl-tyrosine dephosphorylation,GO:0035773~insulin secretion involved in cellular response to glucose stimulus, GO:0005788~endoplasmic reticulum lumen,GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane,GO:0030054~cell junction,GO:0030667~secretory granule membrane,GO:0030672~synaptic vesicle membrane,GO:0043195~terminal bouton,GO:0043235~receptor complex, GO:0004725~protein tyrosine phosphatase activity,GO:0005001~transmembrane receptor protein tyrosine phosphatase activity, IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR003595:Protein-tyrosine phosphatase, catalytic,IPR016130:Protein-tyrosine phosphatase, active site,IPR021613:Protein-tyrosine phosphatase receptor IA-2, hsa04940:Type I diabetes mellitus, SM00194:PTPc,SM00404:PTPc_motif, 3D-structure,Acetylation,Alternative splicing,Cell junction,Complete proteome,Cytoplasmic vesicle,Diabetes mellitus,Glycoprotein,Hydrolase,Lipid metabolism,Membrane,Phospholipid metabolism,Phosphoprotein,Polymorphism,Protein phosphatase,Proteomics identification,Receptor,Reference proteome,Signal,Synapse,Transmembrane,Transmembrane helix, active site:Phosphocysteine intermediate,chain:Receptor-type tyrosine-protein phosphatase N2,domain:Tyrosine-protein phosphatase,glycosylation site:N-linked (GlcNAc...),helix,modified residue,mutagenesis site,sequence conflict,sequence variant,signal peptide,site:Cleavage,splice variant,strand,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region,turn, P28828 protein tyrosine phosphatase, receptor type, M(Ptprm) Mus musculus GO:0001937~negative regulation of endothelial cell proliferation,GO:0006470~protein dephosphorylation,GO:0007155~cell adhesion,GO:0007156~homophilic cell adhesion via plasma membrane adhesion molecules,GO:0007165~signal transduction,GO:0010596~negative regulation of endothelial cell migration,GO:0010842~retina layer formation,GO:0016311~dephosphorylation,GO:0016525~negative regulation of angiogenesis,GO:0031175~neuron projection development,GO:0031290~retinal ganglion cell axon guidance,GO:0042493~response to drug,GO:0045909~positive regulation of vasodilation, GO:0005737~cytoplasm,GO:0005911~cell-cell junction,GO:0005913~cell-cell adherens junction,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030027~lamellipodium,GO:0048471~perinuclear region of cytoplasm, GO:0004721~phosphoprotein phosphatase activity,GO:0004725~protein tyrosine phosphatase activity,GO:0005001~transmembrane receptor protein tyrosine phosphatase activity,GO:0016787~hydrolase activity,GO:0016791~phosphatase activity,GO:0042802~identical protein binding,GO:0045296~cadherin binding, IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type,IPR000387:Protein-tyrosine/Dual specificity phosphatase,IPR000998:MAM domain,IPR003595:Protein-tyrosine phosphatase, catalytic,IPR003599:Immunoglobulin subtype,IPR003961:Fibronectin, type III,IPR007110:Immunoglobulin-like domain,IPR013151:Immunoglobulin,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR013783:Immunoglobulin-like fold,IPR016130:Protein-tyrosine phosphatase, active site, mmu04514:Cell adhesion molecules (CAMs),mmu04520:Adherens junction, SM00060:FN3,SM00137:MAM,SM00194:PTPc,SM00404:PTPc_motif,SM00409:IG, Cell adhesion,Complete proteome,Disulfide bond,Glycoprotein,Hydrolase,Immunoglobulin domain,Membrane,Phosphoprotein,Protein phosphatase,Receptor,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, active site:Phosphocysteine intermediate,chain:Receptor-type tyrosine-protein phosphatase mu,disulfide bond,domain:Fibronectin type-III 1,domain:Fibronectin type-III 2,domain:Fibronectin type-III 3,domain:Fibronectin type-III 4,domain:Ig-like C2-type,domain:MAM,domain:Tyrosine-protein phosphatase 1,domain:Tyrosine-protein phosphatase 2,glycosylation site:N-linked (GlcNAc...),modified residue,sequence conflict,signal peptide,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q5BJR4 prune homolog 2(Prune2) Rattus norvegicus GO:0006915~apoptotic process, GO:0005737~cytoplasm, IPR001251:CRAL-TRIO domain,IPR022181:Bcl2-/adenovirus E1B 19kDa-interacting protein 2, SM00516:SEC14, Apoptosis,Complete proteome,Cytoplasm,Reference proteome, chain:BNIP2 motif-containing molecule at the C- terminal region 1,domain:CRAL-TRIO, Q3MIT2 pseudouridylate synthase 10(PUS10) Homo sapiens GO:0001522~pseudouridine synthesis,GO:0031119~tRNA pseudouridine synthesis, GO:0003723~RNA binding,GO:0009982~pseudouridine synthase activity, IPR020103:Pseudouridine synthase, catalytic domain, 3D-structure,Coiled coil,Complete proteome,Isomerase,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,tRNA processing, active site:Nucleophile,binding site:Substrate,chain:Putative tRNA pseudouridine synthase Pus10,helix,modified residue,region of interest:RNA binding forefinger loop,region of interest:RNA binding thumb loop,sequence conflict,sequence variant,strand,turn, P42669 purine rich element binding protein A(Pura) Mus musculus GO:0006268~DNA unwinding involved in DNA replication,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006915~apoptotic process,GO:0007093~mitotic cell cycle checkpoint,GO:0007399~nervous system development,GO:0008283~cell proliferation,GO:0008284~positive regulation of cell proliferation,GO:0030154~cell differentiation,GO:0042127~regulation of cell proliferation,GO:0045892~negative regulation of transcription, DNA-templated, GO:0005634~nucleus,GO:0005662~DNA replication factor A complex,GO:0005737~cytoplasm,GO:0030425~dendrite,GO:0043025~neuronal cell body, GO:0000900~translation repressor activity, nucleic acid binding,GO:0003677~DNA binding,GO:0003690~double-stranded DNA binding,GO:0003691~double-stranded telomeric DNA binding,GO:0003697~single-stranded DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0003723~RNA binding,GO:0005515~protein binding,GO:0008134~transcription factor binding,GO:0032422~purine-rich negative regulatory element binding,GO:0044822~poly(A) RNA binding,GO:0046332~SMAD binding, IPR006628:PUR-alpha/beta/gamma, DNA/RNA-binding, SM00712:PUR, Acetylation,Activator,Coiled coil,Complete proteome,Direct protein sequencing,DNA-binding,Nucleus,Phosphoprotein,Reference proteome,Transcription,Transcription regulation, chain:Transcriptional activator protein Pur- alpha,compositionally biased region:Gln/Glu-rich (part of the transcriptional activation domain),compositionally biased region:Gly-rich,modified residue, O00370 putative p150(LOC100128274) Homo sapiens GO:0006310~DNA recombination,GO:0032197~transposition, RNA-mediated,GO:0032199~reverse transcription involved in RNA-mediated transposition,GO:0090305~nucleic acid phosphodiester bond hydrolysis, GO:0003964~RNA-directed DNA polymerase activity,GO:0009036~Type II site-specific deoxyribonuclease activity,GO:0046872~metal ion binding, IPR000477:Reverse transcriptase,IPR005135:Endonuclease/exonuclease/phosphatase,IPR013544:Domain of unknown function DUF1725, 3D-structure,Complete proteome,DNA recombination,Endonuclease,Hydrolase,Magnesium,Metal-binding,Multifunctional enzyme,Nuclease,Nucleotidyltransferase,Reference proteome,RNA-directed DNA polymerase,Transferase, Q9P0J1 pyruvate dehyrogenase phosphatase catalytic subunit 1(PDP1) Homo sapiens GO:0010510~regulation of acetyl-CoA biosynthetic process from pyruvate,GO:0035970~peptidyl-threonine dephosphorylation, GO:0005759~mitochondrial matrix, GO:0004722~protein serine/threonine phosphatase activity,GO:0004741~[pyruvate dehydrogenase (lipoamide)] phosphatase activity,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0043169~cation binding,GO:0046872~metal ion binding, IPR000222:Protein phosphatase 2C, manganese/magnesium aspartate binding site,IPR001932:Protein phosphatase 2C (PP2C)-like,IPR015655:Protein phosphatase 2C, 608782~Pyruvate dehydrogenase phosphatase deficiency, SM00332:PP2Cc, Acetylation,Alternative splicing,Calcium,Complete proteome,Disease mutation,Hydrolase,Magnesium,Metal-binding,Mitochondrion,Protein phosphatase,Proteomics identification,Reference proteome,Transit peptide, chain:[Pyruvate dehydrogenase [acetyl- transferring]]-phosphatase 1, mitochondrial,metal ion-binding site:Magnesium 1,metal ion-binding site:Magnesium 1; via carbonyl oxygen,metal ion-binding site:Magnesium 2,modified residue,sequence conflict,sequence variant,transit peptide:Mitochondrion, P14618 pyruvate kinase, muscle(PKM) Homo sapiens GO:0001666~response to hypoxia,GO:0001889~liver development,GO:0006754~ATP biosynthetic process,GO:0007584~response to nutrient,GO:0009629~response to gravity,GO:0012501~programmed cell death,GO:0014870~response to muscle inactivity,GO:0031100~organ regeneration,GO:0032868~response to insulin,GO:0042866~pyruvate biosynthetic process,GO:0043403~skeletal muscle tissue regeneration,GO:0061621~canonical glycolysis,GO:0098609~cell-cell adhesion, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005913~cell-cell adherens junction,GO:0005929~cilium,GO:0031012~extracellular matrix,GO:0031982~vesicle,GO:0043209~myelin sheath,GO:0070062~extracellular exosome,GO:1903561~extracellular vesicle, GO:0000287~magnesium ion binding,GO:0004743~pyruvate kinase activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0023026~MHC class II protein complex binding,GO:0030955~potassium ion binding,GO:0043531~ADP binding,GO:0044822~poly(A) RNA binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR001697:Pyruvate kinase,IPR011037:Pyruvate kinase-like, insert domain,IPR015793:Pyruvate kinase, barrel,IPR015794:Pyruvate kinase, alpha/beta,IPR015795:Pyruvate kinase, C-terminal,IPR015806:Pyruvate kinase, beta-barrel insert domain,IPR015813:Pyruvate/Phosphoenolpyruvate kinase-like domain,IPR018209:Pyruvate kinase, active site, hsa00010:Glycolysis / Gluconeogenesis,hsa00230:Purine metabolism,hsa00620:Pyruvate metabolism,hsa01100:Metabolic pathways,hsa01130:Biosynthesis of antibiotics,hsa01200:Carbon metabolism,hsa01230:Biosynthesis of amino acids,hsa04922:Glucagon signaling pathway,hsa04930:Type II diabetes mellitus,hsa05203:Viral carcinogenesis,hsa05230:Central carbon metabolism in cancer, 3D-structure,Acetylation,Allosteric enzyme,Alternative splicing,ATP-binding,Complete proteome,Cytoplasm,Direct protein sequencing,Glycolysis,Hydroxylation,Isopeptide bond,Kinase,Magnesium,Metal-binding,Methylation,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Potassium,Proteomics identification,Pyruvate,Reference proteome,Transferase,Ubl conjugation, binding site:D-fructose 1,6-bisphosphate; part of allosteric site,binding site:Substrate,binding site:Substrate; via amide nitrogen,chain:Pyruvate kinase isozymes M1/M2,helix,metal ion-binding site:Magnesium,metal ion-binding site:Potassium,modified residue,region of interest:D-fructose 1,6-bisphosphate binding; part of allosteric site,region of interest:Interaction with POU5F1,region of interest:Intersubunit contact,sequence conflict,sequence variant,site:Transition state stabilizer,splice variant,strand,turn, Q9H1K0 rabenosyn, RAB effector(RBSN) Homo sapiens GO:0000011~vacuole inheritance,GO:0006895~Golgi to endosome transport,GO:0006896~Golgi to vacuole transport,GO:0006897~endocytosis,GO:0007596~blood coagulation,GO:0015031~protein transport,GO:0016197~endosomal transport,GO:0034058~endosomal vesicle fusion,GO:0034498~early endosome to Golgi transport,GO:0090160~Golgi to lysosome transport,GO:1903358~regulation of Golgi organization, GO:0005768~endosome,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0010008~endosome membrane,GO:0010009~cytoplasmic side of endosome membrane,GO:0031901~early endosome membrane,GO:0043231~intracellular membrane-bounded organelle,GO:0070062~extracellular exosome, GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0017137~Rab GTPase binding,GO:0046872~metal ion binding, IPR000306:Zinc finger, FYVE-type,IPR007087:Zinc finger, C2H2,IPR011011:Zinc finger, FYVE/PHD-type,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR017455:Zinc finger, FYVE-related,IPR021565:FYVE-finger-containing Rab5 effector protein rabenosyn-5, hsa04144:Endocytosis, SM00064:FYVE, 3D-structure,Acetylation,Alternative splicing,Cell membrane,Coiled coil,Complete proteome,Endosome,Lipoprotein,Membrane,Metal-binding,Phosphoprotein,Polymorphism,Protein transport,Proteomics identification,Reference proteome,Transport,Zinc,Zinc-finger, chain:Rabenosyn-5,compositionally biased region:Poly-Glu,compositionally biased region:Ser-rich,helix,modified residue,mutagenesis site,region of interest:Necessary for the correct targeting to endosomes,region of interest:Necessary for the interaction with EHD1,region of interest:Necessary for the interaction with RAB4A,region of interest:Necessary for the interaction with RAB5A,repeat:UIM,sequence conflict,sequence variant,zinc finger region:C2H2-type,zinc finger region:FYVE-type, Q9DA80 radial spoke 3B homolog (Chlamydomonas)(Rsph3b) Mus musculus IPR009290:Radial spoke 3, Coiled coil,Complete proteome,Phosphoprotein,Reference proteome, chain:Radial spoke head protein 3 homolog A,chain:Radial spoke head protein 3 homolog B,compositionally biased region:Poly-Glu,sequence conflict, Q5ZM73 ras homolog family member T1(RHOT1) Gallus gallus GO:0007264~small GTPase mediated signal transduction,GO:0019725~cellular homeostasis,GO:0047497~mitochondrion transport along microtubule,GO:0097345~mitochondrial outer membrane permeabilization, GO:0031307~integral component of mitochondrial outer membrane, GO:0003924~GTPase activity,GO:0005509~calcium ion binding,GO:0005525~GTP binding, IPR001806:Small GTPase superfamily,IPR002048:EF-hand domain,IPR005225:Small GTP-binding protein domain,IPR011992:EF-hand-like domain,IPR013566:EF hand associated, type-1,IPR013567:EF hand associated, type-2,IPR018247:EF-Hand 1, calcium-binding site,IPR020860:MIRO,IPR021181:Small GTPase superfamily, mitochondrial rho type,IPR027417:P-loop containing nucleoside triphosphate hydrolase, PIRSF037488:mitochondrial Rho GTPase, SM00054:EFh, Calcium,Complete proteome,GTP-binding,Hydrolase,Membrane,Metal-binding,Mitochondrion,Mitochondrion outer membrane,Nucleotide-binding,Reference proteome,Repeat,Transmembrane,Transmembrane helix, calcium-binding region:1,calcium-binding region:2,chain:Mitochondrial Rho GTPase 1,domain:EF-hand 1,domain:EF-hand 2,domain:Miro 1,domain:Miro 2,nucleotide phosphate-binding region:GTP 1,nucleotide phosphate-binding region:GTP 2,topological domain:Cytoplasmic,topological domain:Mitochondrial intermembrane,transmembrane region, O42249 receptor for activated C kinase 1(gnb2l1) Oreochromis niloticus GO:0001525~angiogenesis,GO:0030178~negative regulation of Wnt signaling pathway,GO:0032880~regulation of protein localization,GO:0051302~regulation of cell division,GO:0060027~convergent extension involved in gastrulation,GO:2000114~regulation of establishment of cell polarity,GO:2000543~positive regulation of gastrulation, GO:0005737~cytoplasm, IPR001680:WD40 repeat,IPR015943:WD40/YVTN repeat-like-containing domain,IPR017986:WD40-repeat-containing domain,IPR019775:WD40 repeat, conserved site,IPR020472:G-protein beta WD-40 repeat, SM00320:WD40, Complete proteome,Cytoplasm,Reference proteome,Repeat,WD repeat, Q8K4Q0 regulatory associated protein of MTOR, complex 1(Rptor) Mus musculus Intracellular trafficking and secretion, GO:0001932~regulation of protein phosphorylation,GO:0001938~positive regulation of endothelial cell proliferation,GO:0008361~regulation of cell size,GO:0016049~cell growth,GO:0031669~cellular response to nutrient levels,GO:0031929~TOR signaling,GO:0032008~positive regulation of TOR signaling,GO:0042325~regulation of phosphorylation,GO:0045945~positive regulation of transcription from RNA polymerase III promoter,GO:0046676~negative regulation of insulin secretion,GO:0071230~cellular response to amino acid stimulus,GO:0071902~positive regulation of protein serine/threonine kinase activity, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005764~lysosome,GO:0005765~lysosomal membrane,GO:0030425~dendrite,GO:0031931~TORC1 complex,GO:0043025~neuronal cell body,GO:0043231~intracellular membrane-bounded organelle, GO:0001030~RNA polymerase III type 1 promoter DNA binding,GO:0001031~RNA polymerase III type 2 promoter DNA binding,GO:0001032~RNA polymerase III type 3 promoter DNA binding,GO:0001156~TFIIIC-class transcription factor binding,GO:0019901~protein kinase binding,GO:0030295~protein kinase activator activity,GO:0030674~protein binding, bridging,GO:0032403~protein complex binding,GO:0071889~14-3-3 protein binding, IPR000357:HEAT,IPR001680:WD40 repeat,IPR004083:Regulatory associated protein of TOR,IPR011989:Armadillo-like helical,IPR015943:WD40/YVTN repeat-like-containing domain,IPR016024:Armadillo-type fold,IPR017986:WD40-repeat-containing domain, mmu04150:mTOR signaling pathway,mmu04151:PI3K-Akt signaling pathway,mmu04152:AMPK signaling pathway,mmu04910:Insulin signaling pathway,mmu05206:MicroRNAs in cancer, SM00320:WD40,SM01302:SM01302, Alternative splicing,Complete proteome,Cytoplasm,Lysosome,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Signal,WD repeat, chain:Regulatory-associated protein of mTOR,modified residue,repeat:WD 1,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,sequence conflict,splice variant, P48382 regulatory factor X5(RFX5) Homo sapiens GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0006351~transcription, DNA-templated,GO:0006357~regulation of transcription from RNA polymerase II promoter, GO:0005634~nucleus, GO:0000978~RNA polymerase II core promoter proximal region sequence-specific DNA binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0005515~protein binding, IPR003150:DNA-binding RFX-type winged-helix domain,IPR011991:Winged helix-turn-helix DNA-binding domain, hsa04612:Antigen processing and presentation,hsa05152:Tuberculosis,hsa05340:Primary immunodeficiency, 209920~Bare lymphocyte syndrome, type II, complementation group C,209920~Bare lymphocyte syndrome, type II, complementation group E, SM01306:SM01306, 3D-structure,Acetylation,Activator,Alternative splicing,Complete proteome,Direct protein sequencing,Disease mutation,DNA-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,SCID,Transcription,Transcription regulation, chain:DNA-binding protein RFX5,DNA-binding region:H-T-H motif winged-type,sequence variant, E1C2U2 replication timing regulatory factor 1(RIF1) Gallus gallus GO:0019827~stem cell population maintenance,GO:2001034~positive regulation of double-strand break repair via nonhomologous end joining, GO:0000781~chromosome, telomeric region,GO:0001939~female pronucleus,GO:0001940~male pronucleus,GO:0005886~plasma membrane, IPR016024:Armadillo-type fold,IPR022031:Rap1-interacting factor 1 N-terminal, Complete proteome,Reference proteome, Q9ZSJ0 rhamnogalacturonan xylosyltransferase 2(RGXT2) Arabidopsis thaliana GO:0010306~rhamnogalacturonan II biosynthetic process,GO:0071555~cell wall organization, GO:0000139~Golgi membrane,GO:0005794~Golgi apparatus,GO:0009507~chloroplast,GO:0016021~integral component of membrane, GO:0016757~transferase activity, transferring glycosyl groups,GO:0035252~UDP-xylosyltransferase activity, IPR005069:Nucleotide-diphospho-sugar transferase, Cell wall biogenesis/degradation,Complete proteome,Glycoprotein,Glycosyltransferase,Golgi apparatus,Membrane,Reference proteome,Signal-anchor,Transferase,Transmembrane,Transmembrane helix, P02362 ribosomal protein S8(rps7) Xenopus laevis GO:0006412~translation, GO:0005840~ribosome, GO:0003735~structural constituent of ribosome, IPR000554:Ribosomal protein S7e, xla03010:Ribosome, Ribonucleoprotein,Ribosomal protein, chain:40S ribosomal protein S7,compositionally biased region:Arg/Lys-rich (basic), A0A0R4IBK5 ring finger protein 213a(rnf213a) Danio rerio General function prediction only, GO:0001525~angiogenesis,GO:0002040~sprouting angiogenesis,GO:0016567~protein ubiquitination, GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0004842~ubiquitin-protein transferase activity,GO:0008270~zinc ion binding,GO:0008766~UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,GO:0016787~hydrolase activity,GO:0016874~ligase activity,GO:0016887~ATPase activity,GO:0018169~ribosomal S6-glutamic acid ligase activity,GO:0043773~coenzyme F420-0 gamma-glutamyl ligase activity,GO:0043774~coenzyme F420-2 alpha-glutamyl ligase activity,GO:0046872~metal ion binding,GO:0070735~protein-glycine ligase activity,GO:0070736~protein-glycine ligase activity, initiating,GO:0070737~protein-glycine ligase activity, elongating,GO:0070738~tubulin-glycine ligase activity,GO:0070739~protein-glutamic acid ligase activity,GO:0070740~tubulin-glutamic acid ligase activity, IPR001841:Zinc finger, RING-type,IPR003593:AAA+ ATPase domain,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR017907:Zinc finger, RING-type, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00184:RING,SM00382:AAA, Angiogenesis,Complete proteome,Cytoplasm,Hydrolase,Ligase,Metal-binding,Reference proteome,Ubl conjugation pathway,Zinc,Zinc-finger, P58283 ring finger protein 216(Rnf216) Mus musculus GO:0006915~apoptotic process,GO:0032648~regulation of interferon-beta production,GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process,GO:0050691~regulation of defense response to virus by host,GO:0070936~protein K48-linked ubiquitination,GO:0097039~protein linear polyubiquitination, GO:0000151~ubiquitin ligase complex,GO:0005634~nucleus,GO:0005737~cytoplasm, GO:0004842~ubiquitin-protein transferase activity,GO:0016874~ligase activity,GO:0043130~ubiquitin binding,GO:0046872~metal ion binding,GO:0061630~ubiquitin protein ligase activity, IPR002867:Zinc finger, C6HC-type, SM00647:IBR, Alternative splicing,Apoptosis,Coiled coil,Complete proteome,Cytoplasm,Isopeptide bond,Ligase,Metal-binding,Phosphoprotein,Reference proteome,Repeat,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, chain:E3 ubiquitin-protein ligase RNF216,modified residue,sequence conflict,splice variant,zinc finger region:IBR-type,zinc finger region:RING-type 1,zinc finger region:RING-type 2, Q9Y225 ring finger protein 24(RNF24) Homo sapiens GO:0000209~protein polyubiquitination,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process,GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process, GO:0000139~Golgi membrane,GO:0016021~integral component of membrane, GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0061630~ubiquitin protein ligase activity, IPR001841:Zinc finger, RING-type,IPR011016:Zinc finger, RING-CH-type,IPR013083:Zinc finger, RING/FYVE/PHD-type, SM00184:RING,SM00744:RINGv, 3D-structure,Alternative splicing,Complete proteome,Golgi apparatus,Membrane,Metal-binding,Reference proteome,Transmembrane,Transmembrane helix,Zinc,Zinc-finger, chain:RING finger protein 24,helix,sequence conflict,strand,transmembrane region,turn,zinc finger region:RING-type, Q61909 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)(Runx1t1) Mus musculus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0010977~negative regulation of neuron projection development,GO:0045444~fat cell differentiation,GO:0045599~negative regulation of fat cell differentiation,GO:0045892~negative regulation of transcription, DNA-templated,GO:0051101~regulation of DNA binding, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0016021~integral component of membrane,GO:0016363~nuclear matrix,GO:0017053~transcriptional repressor complex, GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0003714~transcription corepressor activity,GO:0005515~protein binding,GO:0042803~protein homodimerization activity,GO:0046872~metal ion binding, IPR002893:Zinc finger, MYND-type,IPR003894:TAFH/NHR1,IPR013289:Eight-Twenty-One,IPR013290:Myeloid transforming gene on chromosome 8 (MTG8),IPR014896:NHR2-like, mmu05200:Pathways in cancer,mmu05202:Transcriptional misregulation in cancer,mmu05221:Acute myeloid leukemia, SM00549:TAFH, Coiled coil,Complete proteome,Cyclin,DNA-binding,Membrane,Metal-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repressor,Transcription,Transcription regulation,Transmembrane,Transmembrane helix,Zinc,Zinc-finger, chain:Protein CBFA2T1,compositionally biased region:Poly-Pro,compositionally biased region:Poly-Ser,domain:TAFH,modified residue,region of interest:Important for oligomerization,zinc finger region:MYND-type, Q8NBX0 saccharopine dehydrogenase (putative)(SCCPDH) Homo sapiens GO:0055114~oxidation-reduction process, GO:0005634~nucleus,GO:0005739~mitochondrion,GO:0005811~lipid particle,GO:0016020~membrane,GO:0030496~midbody, GO:0016491~oxidoreductase activity, IPR005097:Saccharopine dehydrogenase / Homospermidine synthase,IPR016040:NAD(P)-binding domain, Acetylation,Complete proteome,Direct protein sequencing,Oxidoreductase,Phosphoprotein,Polymorphism,Reference proteome, chain:Probable saccharopine dehydrogenase,modified residue,sequence conflict,sequence variant, Q9NZJ4 sacsin molecular chaperone(SACS) Homo sapiens Posttranslational modification, protein turnover, chaperones, GO:0006457~protein folding,GO:0090084~negative regulation of inclusion body assembly, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0030424~axon,GO:0030425~dendrite,GO:0070852~cell body fiber, GO:0030544~Hsp70 protein binding,GO:0051087~chaperone binding,GO:0070628~proteasome binding, IPR000626:Ubiquitin,IPR001623:DnaJ domain,IPR003594:Histidine kinase-like ATPase, ATP-binding domain,IPR007842:HEPN, 270550~Spastic ataxia, Charlevoix-Saguenay type, SM00748:HEPN, 3D-structure,Acetylation,Alternative splicing,Chaperone,Complete proteome,Cytoplasm,Disease mutation,Neurodegeneration,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:Sacsin,domain:HEPN,domain:J,helix,modified residue,sequence conflict,sequence variant,splice variant,strand,turn, Q7KRY7 scribbled(scrib) Drosophila melanogaster Function unknown, GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0000902~cell morphogenesis,GO:0001708~cell fate specification,GO:0001737~establishment of imaginal disc-derived wing hair orientation,GO:0001738~morphogenesis of a polarized epithelium,GO:0007318~pole plasm protein localization,GO:0007391~dorsal closure,GO:0007464~R3/R4 cell fate commitment,GO:0007472~wing disc morphogenesis,GO:0007608~sensory perception of smell,GO:0007613~memory,GO:0008105~asymmetric protein localization,GO:0008283~cell proliferation,GO:0008285~negative regulation of cell proliferation,GO:0008593~regulation of Notch signaling pathway,GO:0016331~morphogenesis of embryonic epithelium,GO:0016332~establishment or maintenance of polarity of embryonic epithelium,GO:0016333~morphogenesis of follicular epithelium,GO:0016334~establishment or maintenance of polarity of follicular epithelium,GO:0016335~morphogenesis of larval imaginal disc epithelium,GO:0016336~establishment or maintenance of polarity of larval imaginal disc epithelium,GO:0019991~septate junction assembly,GO:0030100~regulation of endocytosis,GO:0030707~ovarian follicle cell development,GO:0030714~anterior/posterior axis specification, follicular epithelium,GO:0035088~establishment or maintenance of apical/basal cell polarity,GO:0042048~olfactory behavior,GO:0042058~regulation of epidermal growth factor receptor signaling pathway,GO:0042067~establishment of ommatidial planar polarity,GO:0045186~zonula adherens assembly,GO:0045197~establishment or maintenance of epithelial cell apical/basal polarity,GO:0045198~establishment of epithelial cell apical/basal polarity,GO:0045571~negative regulation of imaginal disc growth,GO:0045823~positive regulation of heart contraction,GO:0046425~regulation of JAK-STAT cascade,GO:0048749~compound eye development,GO:0048863~stem cell differentiation,GO:0050680~negative regulation of epithelial cell proliferation,GO:0050803~regulation of synapse structure or activity,GO:0051726~regulation of cell cycle,GO:0060581~cell fate commitment involved in pattern specification,GO:0072002~Malpighian tubule development,GO:0072089~stem cell proliferation, GO:0005576~extracellular region,GO:0005918~septate junction,GO:0005923~bicellular tight junction,GO:0016323~basolateral plasma membrane,GO:0016327~apicolateral plasma membrane,GO:0016328~lateral plasma membrane,GO:0031594~neuromuscular junction,GO:0045169~fusome, GO:0005179~hormone activity,GO:0005515~protein binding, IPR001478:PDZ domain,IPR001611:Leucine-rich repeat,IPR003591:Leucine-rich repeat, typical subtype, dme04391:Hippo signaling pathway - fly, SM00228:PDZ,SM00369:LRR_TYP, Alternative splicing,Cell junction,Cell membrane,Coiled coil,Complete proteome,Cytoplasm,Developmental protein,Differentiation,Leucine-rich repeat,Membrane,Neurogenesis,Olfaction,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Sensory transduction,Tight junction, chain:Protein lap4,compositionally biased region:Gln-rich,compositionally biased region:Leu-rich,domain:PDZ 1,domain:PDZ 2,domain:PDZ 3,domain:PDZ 4,modified residue,repeat:LRR 1,repeat:LRR 10,repeat:LRR 11,repeat:LRR 12,repeat:LRR 13,repeat:LRR 14,repeat:LRR 15,repeat:LRR 2,repeat:LRR 3,repeat:LRR 4,repeat:LRR 5,repeat:LRR 6,repeat:LRR 7,repeat:LRR 8,repeat:LRR 9,sequence conflict,splice variant, Q5TYS5 secernin 2(scrn2) Danio rerio GO:0006508~proteolysis,GO:0006887~exocytosis, GO:0016805~dipeptidase activity, IPR005322:Peptidase C69, dipeptidase A, Complete proteome,Proteomics identification,Reference proteome, chain:Secernin-2, A2A9C3 seizure threshold 2(Szt2) Mus musculus GO:0007417~central nervous system development,GO:0009791~post-embryonic development,GO:0021540~corpus callosum morphogenesis,GO:0043473~pigmentation,GO:1901668~regulation of superoxide dismutase activity, GO:0005777~peroxisome,GO:0070062~extracellular exosome, Alternative splicing,Complete proteome,Peroxisome,Phosphoprotein,Proteomics identification,Reference proteome, Q60519 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B(Sema5b) Mus musculus GO:0001755~neural crest cell migration,GO:0007275~multicellular organism development,GO:0007399~nervous system development,GO:0030154~cell differentiation,GO:0030335~positive regulation of cell migration,GO:0048675~axon extension,GO:0048843~negative regulation of axon extension involved in axon guidance,GO:0050908~detection of light stimulus involved in visual perception,GO:0071526~semaphorin-plexin signaling pathway,GO:0097485~neuron projection guidance,GO:1990138~neuron projection extension, GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0030215~semaphorin receptor binding,GO:0045499~chemorepellent activity, IPR000884:Thrombospondin, type 1 repeat,IPR001627:Semaphorin/CD100 antigen,IPR015943:WD40/YVTN repeat-like-containing domain,IPR016201:Plexin-like fold,IPR027231:Semaphorin, mmu04360:Axon guidance, SM00209:TSP1,SM00423:PSI,SM00630:Sema, Alternative splicing,Complete proteome,Developmental protein,Differentiation,Disulfide bond,Glycoprotein,Membrane,Neurogenesis,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:Semaphorin-5B,disulfide bond,domain:Sema,domain:TSP type-1 1,domain:TSP type-1 2,domain:TSP type-1 3,domain:TSP type-1 4,domain:TSP type-1 5,domain:TSP type-1 6,domain:TSP type-1 7,glycosylation site:N-linked (GlcNAc...),sequence conflict,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q3T106 serine and arginine rich splicing factor 7(SRSF7) Bos taurus GO:0006397~mRNA processing,GO:0008380~RNA splicing,GO:0048025~negative regulation of mRNA splicing, via spliceosome,GO:0051028~mRNA transport, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0070062~extracellular exosome, GO:0000166~nucleotide binding,GO:0008270~zinc ion binding,GO:0044822~poly(A) RNA binding, IPR000504:RNA recognition motif domain,IPR001878:Zinc finger, CCHC-type,IPR012677:Nucleotide-binding, alpha-beta plait, bta03040:Spliceosome,bta05168:Herpes simplex infection, SM00360:RRM, Acetylation,Complete proteome,Cytoplasm,Metal-binding,mRNA processing,mRNA splicing,mRNA transport,Nucleus,Phosphoprotein,Reference proteome,Repeat,Repressor,RNA-binding,Transport,Zinc,Zinc-finger, chain:Splicing factor, arginine/serine-rich 7,compositionally biased region:Arg/Ser-rich (RS domain),domain:RRM,modified residue,region of interest:6 X 8 AA repeats of R-R-S-R-S-X-S-X,repeat:1,repeat:2,repeat:3,repeat:4,repeat:5; approximate,repeat:6; approximate,zinc finger region:CCHC-type, P9WI79 serine/threonine-protein kinase PknD(pknD) Mycobacterium tuberculosis H37Rv Function unknown, GO:0009405~pathogenesis,GO:0016036~cellular response to phosphate starvation,GO:0032091~negative regulation of protein binding,GO:0043085~positive regulation of catalytic activity,GO:0043086~negative regulation of catalytic activity,GO:0045717~negative regulation of fatty acid biosynthetic process, GO:0005576~extracellular region,GO:0005618~cell wall,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane, GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0005524~ATP binding,GO:0030145~manganese ion binding, IPR000719:Protein kinase, catalytic domain,IPR001258:NHL repeat,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR011042:Six-bladed beta-propeller, TolB-like,IPR013017:NHL repeat, subgroup,IPR013658:SMP-30/Gluconolaconase/LRE-like region,IPR017441:Protein kinase, ATP binding site, SM00220:S_TKc, 3D-structure,Acetylation,ATP-binding,Cell membrane,Complete proteome,Kinase,Membrane,Nucleotide-binding,Phosphoprotein,Reference proteome,Repeat,Serine/threonine-protein kinase,Transferase,Transmembrane,Transmembrane helix,Virulence, active site:Proton acceptor,binding site:ATP,chain:Serine/threonine-protein kinase pknD,domain:Protein kinase,helix,modified residue,nucleotide phosphate-binding region:ATP,repeat:NHL 1,repeat:NHL 2,repeat:NHL 3,repeat:NHL 4,repeat:NHL 5,repeat:NHL 6,strand,turn, Q6DRC0 seryl-tRNA synthetase(sars) Danio rerio GO:0001525~angiogenesis,GO:0001569~patterning of blood vessels,GO:0006418~tRNA aminoacylation for protein translation,GO:0006434~seryl-tRNA aminoacylation, GO:0005737~cytoplasm, GO:0000166~nucleotide binding,GO:0004812~aminoacyl-tRNA ligase activity,GO:0004828~serine-tRNA ligase activity,GO:0005524~ATP binding,GO:0016874~ligase activity, IPR002314:Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain,IPR002317:Serine-tRNA ligase, type1,IPR006195:Aminoacyl-tRNA synthetase, class II,IPR010978:tRNA-binding arm,IPR015866:Serine-tRNA synthetase, type1, N-terminal, dre00970:Aminoacyl-tRNA biosynthesis, PIRSF001529:serine-tRNA ligase, Aminoacyl-tRNA synthetase,Complete proteome,Ligase,Proteomics identification,Reference proteome, A8DZE7 short chain dehydrogenase/reductase family 42E, member 1(sdr42e1) Danio rerio Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism, GO:0006694~steroid biosynthetic process,GO:0055114~oxidation-reduction process, GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0000252~C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity,GO:0003854~3-beta-hydroxy-delta5-steroid dehydrogenase activity,GO:0004033~aldo-keto reductase (NADP) activity,GO:0004448~isocitrate dehydrogenase activity,GO:0004495~mevaldate reductase activity,GO:0008875~gluconate dehydrogenase activity,GO:0016229~steroid dehydrogenase activity,GO:0016491~oxidoreductase activity,GO:0016616~oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor,GO:0018451~epoxide dehydrogenase activity,GO:0018452~5-exo-hydroxycamphor dehydrogenase activity,GO:0018453~2-hydroxytetrahydrofuran dehydrogenase activity,GO:0019152~acetoin dehydrogenase activity,GO:0032442~phenylcoumaran benzylic ether reductase activity,GO:0032866~D-xylose:NADP reductase activity,GO:0032867~L-arabinose:NADP reductase activity,GO:0033709~D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity,GO:0033764~steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor,GO:0033765~steroid dehydrogenase activity, acting on the CH-CH group of donors,GO:0034831~(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity,GO:0034840~3-hydroxymenthone dehydrogenase activity,GO:0035380~very long-chain-3-hydroxyacyl-CoA dehydrogenase activity,GO:0035410~dihydrotestosterone 17-beta-dehydrogenase activity,GO:0043713~(R)-2-hydroxyisocaproate dehydrogenase activity,GO:0044103~L-arabinose 1-dehydrogenase (NADP+) activity,GO:0044105~L-xylulose reductase (NAD+) activity,GO:0048258~3-ketoglucose-reductase activity,GO:0051990~(R)-2-hydroxyglutarate dehydrogenase activity,GO:0052677~D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity, IPR002225:3-beta hydroxysteroid dehydrogenase/isomerase,IPR016040:NAD(P)-binding domain, Complete proteome,Membrane,NAD,Oxidoreductase,Reference proteome,Transmembrane,Transmembrane helix, active site:Proton acceptor,binding site:NAD,chain:Short chain dehydrogenase/reductase family 42E member 1,sequence conflict,transmembrane region, A0JPQ7 similar to CG16812-PA(RGD1307554) Rattus norvegicus GO:0005654~nucleoplasm, IPR013761:Sterile alpha motif/pointed domain, Complete proteome,Phosphoprotein,Proteomics identification,Reference proteome, Q5AF03 similar to S. cerevisiae YDR533C(CaO19.7882) Candida albicans SC5314 GO:0019243~methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione, GO:0019172~glyoxalase III activity, IPR002818:ThiJ/PfpI, 3D-structure,Complete proteome,Lyase,Oxidation,Reference proteome,Stress response, Q96EB6 sirtuin 1(SIRT1) Homo sapiens h_pmlPathway:Regulation of transcriptional activity by PML, GO:0000012~single strand break repair,GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0000183~chromatin silencing at rDNA,GO:0000720~pyrimidine dimer repair by nucleotide-excision repair,GO:0000731~DNA synthesis involved in DNA repair,GO:0001525~angiogenesis,GO:0001542~ovulation from ovarian follicle,GO:0001678~cellular glucose homeostasis,GO:0001934~positive regulation of protein phosphorylation,GO:0001938~positive regulation of endothelial cell proliferation,GO:0002821~positive regulation of adaptive immune response,GO:0006260~DNA replication,GO:0006281~DNA repair,GO:0006325~chromatin organization,GO:0006342~chromatin silencing,GO:0006343~establishment of chromatin silencing,GO:0006344~maintenance of chromatin silencing,GO:0006346~methylation-dependent chromatin silencing,GO:0006351~transcription, DNA-templated,GO:0006364~rRNA processing,GO:0006471~protein ADP-ribosylation,GO:0006476~protein deacetylation,GO:0006642~triglyceride mobilization,GO:0006974~cellular response to DNA damage stimulus,GO:0006979~response to oxidative stress,GO:0007283~spermatogenesis,GO:0007346~regulation of mitotic cell cycle,GO:0007517~muscle organ development,GO:0007569~cell aging,GO:0008284~positive regulation of cell proliferation,GO:0008630~intrinsic apoptotic signaling pathway in response to DNA damage,GO:0009267~cellular response to starvation,GO:0010629~negative regulation of gene expression,GO:0010875~positive regulation of cholesterol efflux,GO:0010883~regulation of lipid storage,GO:0010906~regulation of glucose metabolic process,GO:0010934~macrophage cytokine production,GO:0014068~positive regulation of phosphatidylinositol 3-kinase signaling,GO:0016032~viral process,GO:0016239~positive regulation of macroautophagy,GO:0016567~protein ubiquitination,GO:0016575~histone deacetylation,GO:0018394~peptidyl-lysine acetylation,GO:0030225~macrophage differentiation,GO:0030308~negative regulation of cell growth,GO:0030512~negative regulation of transforming growth factor beta receptor signaling pathway,GO:0031393~negative regulation of prostaglandin biosynthetic process,GO:0031648~protein destabilization,GO:0031937~positive regulation of chromatin silencing,GO:0032007~negative regulation of TOR signaling,GO:0032071~regulation of endodeoxyribonuclease activity,GO:0032088~negative regulation of NF-kappaB transcription factor activity,GO:0032868~response to insulin,GO:0032922~circadian regulation of gene expression,GO:0033158~regulation of protein import into nucleus, translocation,GO:0033210~leptin-mediated signaling pathway,GO:0034391~regulation of smooth muscle cell apoptotic process,GO:0034983~peptidyl-lysine deacetylation,GO:0035356~cellular triglyceride homeostasis,GO:0035358~regulation of peroxisome proliferator activated receptor signaling pathway,GO:0042127~regulation of cell proliferation,GO:0042326~negative regulation of phosphorylation,GO:0042542~response to hydrogen peroxide,GO:0042595~behavioral response to starvation,GO:0042632~cholesterol homeostasis,GO:0042771~intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator,GO:0043065~positive regulation of apoptotic process,GO:0043066~negative regulation of apoptotic process,GO:0043124~negative regulation of I-kappaB kinase/NF-kappaB signaling,GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process,GO:0043280~positive regulation of cysteine-type endopeptidase activity involved in apoptotic process,GO:0043433~negative regulation of sequence-specific DNA binding transcription factor activity,GO:0043518~negative regulation of DNA damage response, signal transduction by p53 class mediator,GO:0044321~response to leptin,GO:0045348~positive regulation of MHC class II biosynthetic process,GO:0045599~negative regulation of fat cell differentiation,GO:0045739~positive regulation of DNA repair,GO:0045766~positive regulation of angiogenesis,GO:0045892~negative regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0046628~positive regulation of insulin receptor signaling pathway,GO:0050872~white fat cell differentiation,GO:0051097~negative regulation of helicase activity,GO:0051574~positive regulation of histone H3-K9 methylation,GO:0051898~negative regulation of protein kinase B signaling,GO:0055089~fatty acid homeostasis,GO:0060766~negative regulation of androgen receptor signaling pathway,GO:0061647~histone H3-K9 modification,GO:0070301~cellular response to hydrogen peroxide,GO:0070857~regulation of bile acid biosynthetic process,GO:0070914~UV-damage excision repair,GO:0070932~histone H3 deacetylation,GO:0071356~cellular response to tumor necrosis factor,GO:0071441~negative regulation of histone H3-K14 acetylation,GO:0071456~cellular response to hypoxia,GO:0071479~cellular response to ionizing radiation,GO:0071900~regulation of protein serine/threonine kinase activity,GO:0090335~regulation of brown fat cell differentiation,GO:0090400~stress-induced premature senescence,GO:1900034~regulation of cellular response to heat,GO:1901215~negative regulation of neuron death,GO:1901984~negative regulation of protein acetylation,GO:1902166~negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator,GO:1902176~negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway,GO:1902237~positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway,GO:1904179~positive regulation of adipose tissue development,GO:1990619~histone H3-K9 deacetylation,GO:2000111~positive regulation of macrophage apoptotic process,GO:2000480~negative regulation of cAMP-dependent protein kinase activity,GO:2000481~positive regulation of cAMP-dependent protein kinase activity,GO:2000619~negative regulation of histone H4-K16 acetylation,GO:2000655~negative regulation of cellular response to testosterone stimulus,GO:2000757~negative regulation of peptidyl-lysine acetylation,GO:2000773~negative regulation of cellular senescence,GO:2000774~positive regulation of cellular senescence, GO:0000790~nuclear chromatin,GO:0005634~nucleus,GO:0005635~nuclear envelope,GO:0005637~nuclear inner membrane,GO:0005654~nucleoplasm,GO:0005677~chromatin silencing complex,GO:0005719~nuclear euchromatin,GO:0005720~nuclear heterochromatin,GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0016605~PML body,GO:0033553~rDNA heterochromatin,GO:0035098~ESC/E(Z) complex, GO:0001046~core promoter sequence-specific DNA binding,GO:0002039~p53 binding,GO:0003714~transcription corepressor activity,GO:0003950~NAD+ ADP-ribosyltransferase activity,GO:0004407~histone deacetylase activity,GO:0005515~protein binding,GO:0008022~protein C-terminus binding,GO:0008134~transcription factor binding,GO:0017136~NAD-dependent histone deacetylase activity,GO:0019213~deacetylase activity,GO:0019899~enzyme binding,GO:0033558~protein deacetylase activity,GO:0034979~NAD-dependent protein deacetylase activity,GO:0035257~nuclear hormone receptor binding,GO:0042393~histone binding,GO:0042802~identical protein binding,GO:0043398~HLH domain binding,GO:0043425~bHLH transcription factor binding,GO:0046872~metal ion binding,GO:0046969~NAD-dependent histone deacetylase activity (H3-K9 specific),GO:0051019~mitogen-activated protein kinase binding,GO:0070403~NAD+ binding,GO:1990254~keratin filament binding, IPR003000:Sirtuin family,IPR026590:Sirtuin family, catalytic core domain,IPR026591:Sirtuin family, catalytic core small domain, hsa04068:FoxO signaling pathway,hsa04152:AMPK signaling pathway,hsa04922:Glucagon signaling pathway,hsa05031:Amphetamine addiction,hsa05206:MicroRNAs in cancer, 3D-structure,Acetylation,Alternative splicing,Apoptosis,Biological rhythms,Complete proteome,Cytoplasm,Developmental protein,Differentiation,Host-virus interaction,Hydrolase,Metal-binding,Methylation,Mitochondrion,Myogenesis,NAD,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,rRNA processing,S-nitrosylation,Transcription,Transcription regulation,Zinc, active site:Proton acceptor,chain:NAD-dependent deacetylase sirtuin-1,compositionally biased region:Ala-rich,compositionally biased region:Poly-Asp,compositionally biased region:Poly-Glu,domain:Deacetylase sirtuin-type,metal ion-binding site:Zinc,modified residue,mutagenesis site,nucleotide phosphate-binding region:NAD,sequence conflict,sequence variant, Q1JQC6 sirtuin 4(SIRT4) Bos taurus GO:0000820~regulation of glutamine family amino acid metabolic process,GO:0006471~protein ADP-ribosylation,GO:0006541~glutamine metabolic process,GO:0006974~cellular response to DNA damage stimulus,GO:0034983~peptidyl-lysine deacetylation,GO:0046322~negative regulation of fatty acid oxidation,GO:0046676~negative regulation of insulin secretion,GO:0046889~positive regulation of lipid biosynthetic process,GO:0072350~tricarboxylic acid metabolic process,GO:1904182~regulation of pyruvate dehydrogenase activity, GO:0005739~mitochondrion,GO:0005743~mitochondrial inner membrane,GO:0005759~mitochondrial matrix, GO:0003950~NAD+ ADP-ribosyltransferase activity,GO:0008270~zinc ion binding,GO:0034979~NAD-dependent protein deacetylase activity,GO:0047708~biotinidase activity,GO:0061690~lipoamidase activity,GO:0070403~NAD+ binding, IPR003000:Sirtuin family,IPR026587:Sirtuin family, class II,IPR026590:Sirtuin family, catalytic core domain,IPR026591:Sirtuin family, catalytic core small domain, Complete proteome,DNA damage,Hydrolase,Metal-binding,Mitochondrion,NAD,Reference proteome,Transferase,Transit peptide,Tumor suppressor,Zinc, active site:Proton acceptor,chain:NAD-dependent ADP-ribosyltransferase sirtuin-4,domain:Deacetylase sirtuin-type,metal ion-binding site:Zinc,modified residue,nucleotide phosphate-binding region:NAD,transit peptide:Mitochondrion, Q6P4T2 small nuclear ribonucleoprotein 200 (U5)(Snrnp200) Mus musculus General function prediction only, GO:0000398~mRNA splicing, via spliceosome,GO:0001649~osteoblast differentiation,GO:0006397~mRNA processing,GO:0008380~RNA splicing, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005681~spliceosomal complex,GO:0005682~U5 snRNP,GO:0016020~membrane,GO:0030529~intracellular ribonucleoprotein complex,GO:0071013~catalytic step 2 spliceosome, GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0004004~ATP-dependent RNA helicase activity,GO:0004386~helicase activity,GO:0005524~ATP binding,GO:0008026~ATP-dependent helicase activity,GO:0016787~hydrolase activity,GO:0042802~identical protein binding,GO:0044822~poly(A) RNA binding, IPR000008:C2 calcium-dependent membrane targeting,IPR001650:Helicase, C-terminal,IPR004179:Sec63 domain,IPR011545:DNA/RNA helicase, DEAD/DEAH box type, N-terminal,IPR011991:Winged helix-turn-helix DNA-binding domain,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR014756:Immunoglobulin E-set,IPR027417:P-loop containing nucleoside triphosphate hydrolase, mmu03040:Spliceosome, SM00487:DEXDc,SM00490:HELICc,SM00973:SM00973, Acetylation,ATP-binding,Coiled coil,Complete proteome,Helicase,Hydrolase,Isopeptide bond,mRNA processing,mRNA splicing,Nucleotide-binding,Nucleus,Phosphoprotein,Reference proteome,Repeat,Ribonucleoprotein,Spliceosome,Ubl conjugation, Q06AA4 small nuclear ribonucleoprotein polypeptide A(SNRPA) Sus scrofa GO:0000398~mRNA splicing, via spliceosome, GO:0005654~nucleoplasm,GO:0005681~spliceosomal complex,GO:0005685~U1 snRNP,GO:0005730~nucleolus,GO:0005737~cytoplasm, GO:0000166~nucleotide binding,GO:0003723~RNA binding,GO:0030619~U1 snRNA binding,GO:0035614~snRNA stem-loop binding,GO:0044822~poly(A) RNA binding, IPR000504:RNA recognition motif domain,IPR012677:Nucleotide-binding, alpha-beta plait,IPR024888:U1 small nuclear ribonucleoprotein A/U2 small nuclear ribonucleoprotein B'', ssc03040:Spliceosome, SM00360:RRM, 3D-structure,Acetylation,Complete proteome,Methylation,mRNA processing,mRNA splicing,Nucleus,Reference proteome,Repeat,Ribonucleoprotein,RNA-binding,Spliceosome, chain:U1 small nuclear ribonucleoprotein A,compositionally biased region:Pro-rich,domain:RRM 1,domain:RRM 2,modified residue, O54902 solute carrier family 11 member 2(Slc11a2) Rattus norvegicus GO:0000041~transition metal ion transport,GO:0001666~response to hypoxia,GO:0003032~detection of oxygen,GO:0006778~porphyrin-containing compound metabolic process,GO:0006779~porphyrin-containing compound biosynthetic process,GO:0006783~heme biosynthetic process,GO:0006810~transport,GO:0006824~cobalt ion transport,GO:0006825~copper ion transport,GO:0006826~iron ion transport,GO:0006828~manganese ion transport,GO:0006878~cellular copper ion homeostasis,GO:0006919~activation of cysteine-type endopeptidase activity involved in apoptotic process,GO:0007611~learning or memory,GO:0010039~response to iron ion,GO:0010042~response to manganese ion,GO:0010288~response to lead ion,GO:0015675~nickel cation transport,GO:0015676~vanadium ion transport,GO:0015684~ferrous iron transport,GO:0015692~lead ion transport,GO:0015992~proton transport,GO:0034599~cellular response to oxidative stress,GO:0035434~copper ion transmembrane transport,GO:0035444~nickel cation transmembrane transport,GO:0046686~response to cadmium ion,GO:0048813~dendrite morphogenesis,GO:0048821~erythrocyte development,GO:0055072~iron ion homeostasis,GO:0060586~multicellular organismal iron ion homeostasis,GO:0070574~cadmium ion transmembrane transport,GO:0070627~ferrous iron import,GO:0071281~cellular response to iron ion,GO:0071356~cellular response to tumor necrosis factor,GO:0071421~manganese ion transmembrane transport,GO:0071456~cellular response to hypoxia,GO:1902600~hydrogen ion transmembrane transport,GO:1902861~copper ion import into cell,GO:1903874~ferrous iron transmembrane transport, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005741~mitochondrial outer membrane,GO:0005764~lysosome,GO:0005765~lysosomal membrane,GO:0005768~endosome,GO:0005769~early endosome,GO:0005770~late endosome,GO:0005773~vacuole,GO:0005802~trans-Golgi network,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0005903~brush border,GO:0009986~cell surface,GO:0012505~endomembrane system,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0016324~apical plasma membrane,GO:0030904~retromer complex,GO:0031410~cytoplasmic vesicle,GO:0031526~brush border membrane,GO:0031902~late endosome membrane,GO:0045177~apical part of cell,GO:0045178~basal part of cell,GO:0048471~perinuclear region of cytoplasm,GO:0055037~recycling endosome,GO:0070826~paraferritin complex, GO:0005215~transporter activity,GO:0005375~copper ion transmembrane transporter activity,GO:0005381~iron ion transmembrane transporter activity,GO:0005384~manganese ion transmembrane transporter activity,GO:0005385~zinc ion transmembrane transporter activity,GO:0005506~iron ion binding,GO:0005507~copper ion binding,GO:0008270~zinc ion binding,GO:0015078~hydrogen ion transmembrane transporter activity,GO:0015085~calcium ion transmembrane transporter activity,GO:0015086~cadmium ion transmembrane transporter activity,GO:0015087~cobalt ion transmembrane transporter activity,GO:0015093~ferrous iron transmembrane transporter activity,GO:0015094~lead ion transmembrane transporter activity,GO:0015099~nickel cation transmembrane transporter activity,GO:0015100~vanadium ion transmembrane transporter activity,GO:0015295~solute:proton symporter activity,GO:0015639~ferrous iron uptake transmembrane transporter activity,GO:0016151~nickel cation binding,GO:0022890~inorganic cation transmembrane transporter activity,GO:0030145~manganese ion binding,GO:0046870~cadmium ion binding,GO:0046915~transition metal ion transmembrane transporter activity,GO:0050897~cobalt ion binding,GO:0070835~chromium ion transmembrane transporter activity, IPR001046:Natural resistance-associated macrophage like, rno04142:Lysosome, Alternative splicing,Cell membrane,Complete proteome,Disease mutation,Endosome,Glycoprotein,Ion transport,Iron,Iron transport,Membrane,Mitochondrion,Mitochondrion outer membrane,Phosphoprotein,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix,Transport,Ubl conjugation, chain:Natural resistance-associated macrophage protein 2,glycosylation site:N-linked (GlcNAc...),modified residue,sequence variant,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q924N4 solute carrier family 12, member 6(Slc12a6) Mus musculus GO:0006811~ion transport,GO:0007268~chemical synaptic transmission,GO:0071477~cellular hypotonic salinity response, GO:0005887~integral component of plasma membrane,GO:0016323~basolateral plasma membrane,GO:0016324~apical plasma membrane,GO:0030424~axon, GO:0005515~protein binding,GO:0015379~potassium:chloride symporter activity,GO:0022820~potassium ion symporter activity, IPR000076:K-Cl co-transporter,IPR004841:Amino acid permease domain,IPR004842:Na/K/Cl co-transporter superfamily,IPR018491:K/Cl co-transporter, type 1/type 3, Alternative promoter usage,Cell membrane,Complete proteome,Direct protein sequencing,Glycoprotein,Ion transport,Membrane,Phosphoprotein,Potassium,Potassium transport,Proteomics identification,Reference proteome,Symport,Transmembrane,Transmembrane helix,Transport, chain:Solute carrier family 12 member 6,compositionally biased region:Poly-Cys,glycosylation site:N-linked (GlcNAc...),modified residue,splice variant,topological domain:Cytoplasmic,transmembrane region, Q9NRA2 solute carrier family 17 member 5(SLC17A5) Homo sapiens GO:0006811~ion transport,GO:0006820~anion transport,GO:0006865~amino acid transport,GO:0008643~carbohydrate transport,GO:0015739~sialic acid transport,GO:0015992~proton transport,GO:0055085~transmembrane transport,GO:1901264~carbohydrate derivative transport, GO:0005737~cytoplasm,GO:0005765~lysosomal membrane,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030054~cell junction,GO:0030672~synaptic vesicle membrane, GO:0005351~sugar:proton symporter activity,GO:0015136~sialic acid transmembrane transporter activity,GO:0015538~sialic acid:proton symporter activity, IPR011701:Major facilitator superfamily,IPR020846:Major facilitator superfamily domain, hsa04142:Lysosome, 269920~Sialic acid storage disorder, infantile,604369~Salla disease, Alternative splicing,Amino-acid transport,Cell junction,Cell membrane,Complete proteome,Cytoplasmic vesicle,Disease mutation,Glycoprotein,Lysosome,Membrane,Phosphoprotein,Reference proteome,Sugar transport,Symport,Synapse,Transmembrane,Transmembrane helix,Transport, chain:Sialin,sequence variant,splice variant,transmembrane region, Q96QE2 solute carrier family 2 member 13(SLC2A13) Homo sapiens GO:0015798~myo-inositol transport,GO:0015992~proton transport,GO:0035428~hexose transmembrane transport,GO:0046323~glucose import,GO:1904659~glucose transmembrane transport, GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane, GO:0005351~sugar:proton symporter activity,GO:0005355~glucose transmembrane transporter activity,GO:0005366~myo-inositol:proton symporter activity,GO:0022891~substrate-specific transmembrane transporter activity, IPR003663:Sugar/inositol transporter,IPR005828:General substrate transporter,IPR005829:Sugar transporter, conserved site,IPR020846:Major facilitator superfamily domain, Complete proteome,Glycoprotein,Membrane,Phosphoprotein,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix,Transport, chain:Proton myo-inositol cotransporter,glycosylation site:N-linked (GlcNAc...),modified residue,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, B0JZG0 solute carrier family 23 (ascorbic acid transporter), member 2(slc23a2) Xenopus tropicalis GO:0016021~integral component of membrane, GO:0070890~sodium-dependent L-ascorbate transmembrane transporter activity, IPR006042:Xanthine/uracil permease,IPR006043:Xanthine/uracil/vitamin C permease, Complete proteome,Glycoprotein,Ion transport,Membrane,Reference proteome,Sodium,Sodium transport,Symport,Transmembrane,Transmembrane helix,Transport, chain:Solute carrier family 23 member 2,glycosylation site:N-linked (GlcNAc...),transmembrane region, Q9ERH8 solute carrier family 28 (sodium-coupled nucleoside transporter), member 3(Slc28a3) Mus musculus GO:0001895~retina homeostasis,GO:0015860~purine nucleoside transmembrane transport,GO:0015864~pyrimidine nucleoside transport,GO:1901642~nucleoside transmembrane transport, GO:0005887~integral component of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0005337~nucleoside transmembrane transporter activity,GO:0015389~pyrimidine- and adenine-specific:sodium symporter activity,GO:0015390~purine-specific nucleoside:sodium symporter activity, IPR002668:Na dependent nucleoside transporter,IPR008276:Concentrative nucleoside transporter,IPR011642:Nucleoside recognition Gate,IPR011657:Na dependent nucleoside transporter, C-terminal,IPR018270:Concentrative nucleoside transporter, metazoan/bacterial, Complete proteome,Membrane,Reference proteome,Transmembrane,Transmembrane helix, chain:Solute carrier family 28 member 3,sequence conflict,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, O15431 solute carrier family 31 member 1(SLC31A1) Homo sapiens GO:0006825~copper ion transport,GO:0006855~drug transmembrane transport,GO:0006878~cellular copper ion homeostasis,GO:0035434~copper ion transmembrane transport,GO:0072719~cellular response to cisplatin,GO:1902861~copper ion import into cell, GO:0005770~late endosome,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane,GO:0043025~neuronal cell body,GO:0055037~recycling endosome, GO:0005375~copper ion transmembrane transporter activity,GO:0015088~copper uptake transmembrane transporter activity, IPR007274:Ctr copper transporter, hsa04978:Mineral absorption, 3D-structure,Cell membrane,Complete proteome,Copper,Copper transport,Glycoprotein,Ion transport,Membrane,Phosphoprotein,Polymorphism,Reference proteome,Transmembrane,Transmembrane helix,Transport, chain:High affinity copper uptake protein 1,glycosylation site:N-linked (GlcNAc...),glycosylation site:O-linked (GalNAc...),sequence conflict,sequence variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, P13808 solute carrier family 4 (anion exchanger), member 2(Slc4a2) Mus musculus GO:0006810~transport,GO:0006811~ion transport,GO:0006820~anion transport,GO:0006821~chloride transport,GO:0007283~spermatogenesis,GO:0048565~digestive tract development,GO:0051453~regulation of intracellular pH, GO:0005623~cell,GO:0005887~integral component of plasma membrane,GO:0005925~focal adhesion,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0016323~basolateral plasma membrane,GO:0016324~apical plasma membrane, GO:0005215~transporter activity,GO:0005452~inorganic anion exchanger activity,GO:0008509~anion transmembrane transporter activity,GO:0015108~chloride transmembrane transporter activity,GO:0015297~antiporter activity,GO:0015301~anion:anion antiporter activity,GO:0019899~enzyme binding, IPR001717:Anion exchange protein,IPR002978:Anion exchange protein 2,IPR003020:Bicarbonate transporter, eukaryotic,IPR011531:Bicarbonate transporter, C-terminal,IPR013769:Band 3 cytoplasmic domain,IPR016152:Phosphotransferase/anion transporter,IPR018241:Anion exchange, conserved site, mmu04970:Salivary secretion,mmu04971:Gastric acid secretion,mmu04972:Pancreatic secretion,mmu04976:Bile secretion, Alternative splicing,Anion exchange,Antiport,Complete proteome,Glycoprotein,Ion transport,Lipoprotein,Membrane,Methylation,Palmitate,Phosphoprotein,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix,Transport, chain:Anion exchange protein 2,compositionally biased region:His-rich,compositionally biased region:Poly-Ser,compositionally biased region:Pro-rich,glycosylation site:N-linked (GlcNAc...),lipid moiety-binding region:S-palmitoyl cysteine,modified residue,region of interest:Membrane (anion exchange),sequence conflict,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q6U841 solute carrier family 4 member 10(SLC4A10) Homo sapiens GO:0006814~sodium ion transport,GO:0006821~chloride transport,GO:0007399~nervous system development,GO:0009416~response to light stimulus,GO:0009791~post-embryonic development,GO:0015701~bicarbonate transport,GO:0021860~pyramidal neuron development,GO:0035264~multicellular organism growth,GO:0035641~locomotory exploration behavior,GO:0048854~brain morphogenesis,GO:0051453~regulation of intracellular pH,GO:0098656~anion transmembrane transport,GO:1902600~hydrogen ion transmembrane transport, GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane,GO:0016323~basolateral plasma membrane,GO:0043025~neuronal cell body,GO:0097440~apical dendrite,GO:0097441~basilar dendrite,GO:0097442~CA3 pyramidal cell dendrite, GO:0005452~inorganic anion exchanger activity,GO:0008509~anion transmembrane transporter activity,GO:0015293~symporter activity,GO:0015301~anion:anion antiporter activity, IPR003020:Bicarbonate transporter, eukaryotic,IPR003024:Sodium bicarbonate cotransporter,IPR011531:Bicarbonate transporter, C-terminal,IPR013769:Band 3 cytoplasmic domain,IPR016152:Phosphotransferase/anion transporter, Alternative splicing,Antiport,Cell membrane,Complete proteome,Ion transport,Membrane,Phosphoprotein,Proteomics identification,Reference proteome,Sodium,Sodium transport,Symport,Transmembrane,Transmembrane helix,Transport, chain:Sodium-driven chloride bicarbonate exchanger,modified residue,sequence conflict,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, A8WHP3 solute carrier family 5 (sodium/sugar cotransporter), member 9(slc5a9) Danio rerio GO:0006810~transport,GO:0006811~ion transport,GO:0006814~sodium ion transport,GO:0055085~transmembrane transport, GO:0005887~integral component of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0005215~transporter activity,GO:0015293~symporter activity, IPR001734:Sodium/solute symporter,IPR018212:Sodium/solute symporter, conserved site, Complete proteome,Glycoprotein,Ion transport,Membrane,Reference proteome,Sodium,Sodium transport,Transmembrane,Transmembrane helix,Transport, chain:Sodium/glucose cotransporter 4,glycosylation site:N-linked (GlcNAc...),topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q28728 solute carrier family 5 member 11(SLC5A11) Oryctolagus cuniculus GO:0006814~sodium ion transport,GO:0006915~apoptotic process,GO:0008643~carbohydrate transport, GO:0016021~integral component of membrane, GO:0015293~symporter activity, IPR001734:Sodium/solute symporter, Apoptosis,Complete proteome,Ion transport,Membrane,Reference proteome,Sodium,Sodium transport,Sugar transport,Symport,Transmembrane,Transmembrane helix,Transport, chain:Sodium/myo-inositol cotransporter 2,sequence conflict,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q925Q3 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1(Slc8b1) Mus musculus GO:0006810~transport,GO:0006811~ion transport,GO:0006814~sodium ion transport,GO:0006816~calcium ion transport,GO:0006851~mitochondrial calcium ion transport,GO:0035725~sodium ion transmembrane transport,GO:0042593~glucose homeostasis,GO:0050796~regulation of insulin secretion,GO:0050896~response to stimulus,GO:0051480~regulation of cytosolic calcium ion concentration,GO:0051560~mitochondrial calcium ion homeostasis,GO:0055085~transmembrane transport,GO:0070588~calcium ion transmembrane transport,GO:0086036~regulation of cardiac muscle cell membrane potential, GO:0005739~mitochondrion,GO:0005743~mitochondrial inner membrane,GO:0005783~endoplasmic reticulum,GO:0005789~endoplasmic reticulum membrane,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030061~mitochondrial crista,GO:0032592~integral component of mitochondrial membrane,GO:0042383~sarcolemma, GO:0005432~calcium:sodium antiporter activity,GO:0015297~antiporter activity,GO:0042802~identical protein binding,GO:0042803~protein homodimerization activity,GO:0086038~calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential, IPR004837:Sodium/calcium exchanger membrane region, Alternative splicing,Antiport,Calcium,Calcium transport,Cell membrane,Complete proteome,Endoplasmic reticulum,Glycoprotein,Ion transport,Lithium,Membrane,Mitochondrion,Mitochondrion inner membrane,Proteomics identification,Reference proteome,Sensory transduction,Signal,Sodium,Sodium transport,Transit peptide,Transmembrane,Transmembrane helix,Transport, chain:Sodium/potassium/calcium exchanger 6,glycosylation site:N-linked (GlcNAc...),sequence conflict,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q5ZJ75 solute carrier family 9 member A8(SLC9A8) Gallus gallus GO:0006885~regulation of pH,GO:0035725~sodium ion transmembrane transport,GO:0051453~regulation of intracellular pH,GO:0071805~potassium ion transmembrane transport,GO:1902600~hydrogen ion transmembrane transport, GO:0000139~Golgi membrane,GO:0005794~Golgi apparatus,GO:0016021~integral component of membrane, GO:0015385~sodium:proton antiporter activity,GO:0015386~potassium:proton antiporter activity, IPR004709:Na+/H+ exchanger,IPR006153:Cation/H+ exchanger,IPR018409:Na+/H+ exchanger, isoform 8, eukaryotic,IPR018422:Cation/H+ exchanger, CPA1 family, Antiport,Complete proteome,Golgi apparatus,Ion transport,Membrane,Reference proteome,Sodium,Sodium transport,Transmembrane,Transmembrane helix,Transport, chain:Sodium/hydrogen exchanger 8,transmembrane region, Q99N01 solute carrier organic anion transporter family, member 4a1(Slco4a1) Rattus norvegicus GO:0006811~ion transport,GO:0042403~thyroid hormone metabolic process,GO:0043252~sodium-independent organic anion transport,GO:0070327~thyroid hormone transport, GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane, GO:0005215~transporter activity,GO:0015347~sodium-independent organic anion transmembrane transporter activity,GO:0015349~thyroid hormone transmembrane transporter activity, IPR002350:Kazal domain,IPR004156:Organic anion transporter polypeptide OATP,IPR020846:Major facilitator superfamily domain, Cell membrane,Complete proteome,Disulfide bond,Glycoprotein,Ion transport,Membrane,Phosphoprotein,Reference proteome,Transmembrane,Transmembrane helix,Transport, chain:Solute carrier organic anion transporter family member 4A1,domain:Kazal-like,glycosylation site:N-linked (GlcNAc...),modified residue,transmembrane region, P0DMQ6 sorbitol dehydrogenase(SORD) Gallus gallus Amino acid transport and metabolism / General function prediction only, GO:0006000~fructose metabolic process,GO:0006061~sorbitol biosynthetic process,GO:0006062~sorbitol catabolic process,GO:0006116~NADH oxidation,GO:0006735~NADH regeneration,GO:0030317~sperm motility,GO:0046370~fructose biosynthetic process,GO:0051160~L-xylitol catabolic process, GO:0031514~motile cilium,GO:0031966~mitochondrial membrane,GO:0032991~macromolecular complex,GO:0070062~extracellular exosome, GO:0003939~L-iditol 2-dehydrogenase activity,GO:0008270~zinc ion binding,GO:0046526~D-xylulose reductase activity,GO:0051287~NAD binding, IPR002085:Alcohol dehydrogenase superfamily, zinc-type,IPR002328:Alcohol dehydrogenase, zinc-type, conserved site,IPR011032:GroES-like,IPR013149:Alcohol dehydrogenase, C-terminal,IPR013154:Alcohol dehydrogenase GroES-like,IPR016040:NAD(P)-binding domain,IPR020843:Polyketide synthase, enoylreductase, gga00040:Pentose and glucuronate interconversions,gga00051:Fructose and mannose metabolism,gga01100:Metabolic pathways, SM00829:SM00829, Acetylation,Cell projection,Cilium,Complete proteome,Flagellum,Membrane,Metal-binding,Mitochondrion,NAD,Oxidoreductase,Reference proteome,Zinc, Q9JLC4 sortilin-related VPS10 domain containing receptor 1(Sorcs1) Mus musculus GO:0016020~membrane,GO:0016021~integral component of membrane, IPR000601:PKD domain,IPR006581:VPS10, SM00602:VPS10, Alternative splicing,Complete proteome,Glycoprotein,Membrane,Proteomics identification,Reference proteome,Repeat,Signal,Transmembrane,Transmembrane helix, chain:VPS10 domain-containing receptor SorCS1,domain:PKD,glycosylation site:N-linked (GlcNAc...),repeat:BNR 1,repeat:BNR 2,repeat:BNR 3,repeat:BNR 4,repeat:BNR 5,sequence conflict,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, F1Q506 sorting nexin 10a(snx10a) Danio rerio GO:0001947~heart looping,GO:0006810~transport,GO:0006897~endocytosis,GO:0015031~protein transport,GO:0016050~vesicle organization,GO:0030030~cell projection organization,GO:0042384~cilium assembly,GO:0060271~cilium morphogenesis,GO:0061512~protein localization to cilium,GO:0070121~Kupffer's vesicle development,GO:0070986~left/right axis specification,GO:0071539~protein localization to centrosome, GO:0005737~cytoplasm,GO:0005768~endosome,GO:0005813~centrosome,GO:0005815~microtubule organizing center,GO:0005856~cytoskeleton,GO:0010008~endosome membrane,GO:0016020~membrane,GO:0019898~extrinsic component of membrane, GO:0008289~lipid binding,GO:0035091~phosphatidylinositol binding, IPR001683:Phox homologous domain, SM00312:PX, Alternative splicing,Cilium biogenesis/degradation,Complete proteome,Cytoplasm,Cytoskeleton,Endosome,Lipid-binding,Membrane,Protein transport,Reference proteome,Transport, A1A4L0 sorting nexin 4(SNX4) Bos taurus Intracellular trafficking and secretion / General function prediction only, GO:0006897~endocytosis,GO:0015031~protein transport,GO:0016050~vesicle organization,GO:0032456~endocytic recycling,GO:1903595~positive regulation of histamine secretion by mast cell, GO:0005768~endosome,GO:0005868~cytoplasmic dynein complex,GO:0005886~plasma membrane,GO:0019898~extrinsic component of membrane,GO:0031201~SNARE complex,GO:0031901~early endosome membrane, GO:0005154~epidermal growth factor receptor binding,GO:0005158~insulin receptor binding,GO:0035091~phosphatidylinositol binding,GO:1990459~transferrin receptor binding,GO:1990460~leptin receptor binding, IPR001683:Phox homologous domain, bta04144:Endocytosis, SM00312:PX, Acetylation,Complete proteome,Endosome,Lipid-binding,Membrane,Protein transport,Reference proteome,Transport, chain:Sorting nexin-4,domain:PX,modified residue, Q8NF91 spectrin repeat containing nuclear envelope protein 1(SYNE1) Homo sapiens Cell division and chromosome partitioning,DNA replication, recombination, and repair, GO:0006997~nucleus organization,GO:0007030~Golgi organization,GO:0042692~muscle cell differentiation,GO:0090286~cytoskeletal anchoring at nuclear membrane,GO:0090292~nuclear matrix anchoring at nuclear membrane, GO:0005634~nucleus,GO:0005635~nuclear envelope,GO:0005640~nuclear outer membrane,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005794~Golgi apparatus,GO:0005856~cytoskeleton,GO:0016021~integral component of membrane,GO:0030017~sarcomere,GO:0031965~nuclear membrane,GO:0034993~LINC complex,GO:0045211~postsynaptic membrane, GO:0003779~actin binding,GO:0005515~protein binding,GO:0005521~lamin binding,GO:0042803~protein homodimerization activity,GO:0044822~poly(A) RNA binding,GO:0051015~actin filament binding, IPR001589:Actinin-type, actin-binding, conserved site,IPR001715:Calponin homology domain,IPR002017:Spectrin repeat,IPR012315:Klarsicht/ANC-1/syne-1 homology,IPR018159:Spectrin/alpha-actinin, 610743~Spinocerebellar ataxia, autosomal recessive 8,612998~Emery-Dreifuss muscular dystrophy 4, autosomal dominant, SM00033:CH,SM00150:SPEC,SM01249:SM01249, 3D-structure,Actin-binding,Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Disease mutation,Emery-Dreifuss muscular dystrophy,Golgi apparatus,Membrane,Neurodegeneration,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Transmembrane,Transmembrane helix, chain:Nesprin-1,compositionally biased region:Ser-rich,domain:Actin-binding,domain:CH 1,domain:CH 2,domain:KASH,modified residue,mutagenesis site,repeat:HAT 1,repeat:HAT 10,repeat:HAT 11,repeat:HAT 12,repeat:HAT 2,repeat:HAT 3,repeat:HAT 4,repeat:HAT 5,repeat:HAT 6,repeat:HAT 7,repeat:HAT 8,repeat:HAT 9,repeat:Spectrin 1,repeat:Spectrin 10,repeat:Spectrin 11,repeat:Spectrin 12,repeat:Spectrin 13,repeat:Spectrin 14,repeat:Spectrin 15,repeat:Spectrin 16,repeat:Spectrin 17,repeat:Spectrin 18,repeat:Spectrin 19,repeat:Spectrin 2,repeat:Spectrin 20,repeat:Spectrin 21,repeat:Spectrin 22,repeat:Spectrin 23,repeat:Spectrin 24,repeat:Spectrin 25,repeat:Spectrin 26,repeat:Spectrin 27,repeat:Spectrin 28,repeat:Spectrin 29,repeat:Spectrin 3,repeat:Spectrin 30,repeat:Spectrin 31,repeat:Spectrin 4,repeat:Spectrin 5,repeat:Spectrin 6,repeat:Spectrin 7,repeat:Spectrin 8,repeat:Spectrin 9,sequence conflict,sequence variant,splice variant,topological domain:Cytoplasmic,topological domain:Perinuclear space,transmembrane region, Q9JLI7 sperm associated antigen 6-like(Spag6l) Mus musculus GO:0007288~sperm axoneme assembly,GO:0021591~ventricular system development,GO:0030030~cell projection organization,GO:0030317~sperm motility, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005874~microtubule,GO:0005929~cilium,GO:0015630~microtubule cytoskeleton,GO:0031514~motile cilium,GO:0042995~cell projection,GO:0097228~sperm principal piece,GO:1990716~axonemal central apparatus, IPR000225:Armadillo,IPR000357:HEAT,IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold, SM00185:ARM, Cell projection,Cilium,Cilium biogenesis/degradation,Complete proteome,Cytoplasm,Cytoskeleton,Flagellum,Microtubule,Reference proteome,Repeat, chain:Sperm-associated antigen 6,repeat:ARM 1,repeat:ARM 2,repeat:ARM 3,repeat:ARM 4,repeat:ARM 5,repeat:ARM 6,repeat:ARM 7,repeat:ARM 8, Q0IH24 sperm flagellar 1 L homeolog(spef1.L) Xenopus laevis GO:0005737~cytoplasm,GO:0005930~axoneme, IPR001715:Calponin homology domain,IPR010441:Protein of unknown function DUF1042, Cell projection,Cilium,Cytoplasm,Cytoskeleton, Q2IA00 sperm flagellar 2(SPEF2) Sus scrofa GO:0002520~immune system development,GO:0007283~spermatogenesis,GO:0009566~fertilization,GO:0010259~multicellular organism aging,GO:0035082~axoneme assembly,GO:0048702~embryonic neurocranium morphogenesis,GO:0048854~brain morphogenesis,GO:0060541~respiratory system development, GO:0002177~manchette,GO:0005794~Golgi apparatus,GO:0097225~sperm midpiece, IPR001715:Calponin homology domain,IPR010441:Protein of unknown function DUF1042,IPR011992:EF-hand-like domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, Coiled coil,Complete proteome,Isopeptide bond,Reference proteome, chain:Sperm flagellar protein 2,compositionally biased region:Pro-rich,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),domain:CH,repeat:LRR 1,repeat:LRR 2, Q9R095 sperm flagellar 2(Spef2) Rattus norvegicus GO:0002520~immune system development,GO:0003351~epithelial cilium movement,GO:0007283~spermatogenesis,GO:0007288~sperm axoneme assembly,GO:0009566~fertilization,GO:0010259~multicellular organism aging,GO:0035082~axoneme assembly,GO:0048702~embryonic neurocranium morphogenesis,GO:0048705~skeletal system morphogenesis,GO:0048854~brain morphogenesis,GO:0060541~respiratory system development, GO:0002177~manchette,GO:0005737~cytoplasm,GO:0005794~Golgi apparatus,GO:0097225~sperm midpiece, IPR001715:Calponin homology domain,IPR010441:Protein of unknown function DUF1042,IPR011992:EF-hand-like domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, Alternative splicing,Coiled coil,Complete proteome,Isopeptide bond,Reference proteome, chain:Sperm flagellar protein 2,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),domain:CH,repeat:LRR 1,repeat:LRR 2,splice variant, Q08BC4 sperm-tail PG-rich repeat containing 2(stpg2) Danio rerio IPR010736:Sperm-tail PG-rich repeat, Complete proteome,Reference proteome,Repeat, chain:Uncharacterized protein C4orf37 homolog, Q503Q1 spermatogenesis associated 18(spata18) Danio rerio GO:0006974~cellular response to DNA damage stimulus,GO:0033554~cellular response to stress,GO:0035694~mitochondrial protein catabolic process,GO:0035695~mitophagy by induced vacuole formation, GO:0005737~cytoplasm,GO:0005739~mitochondrion,GO:0005741~mitochondrial outer membrane,GO:0016020~membrane,GO:0043231~intracellular membrane-bounded organelle, IPR026169:Mitochondria-eating protein, Coiled coil,Complete proteome,Cytoplasm,Membrane,Mitochondrion,Mitochondrion outer membrane,Proteomics identification,Reference proteome, chain:Spermatogenesis-associated protein 18 homolog, Q9BVQ7 spermatogenesis associated 5 like 1(SPATA5L1) Homo sapiens GO:0005737~cytoplasm, GO:0005524~ATP binding, IPR003593:AAA+ ATPase domain,IPR003959:ATPase, AAA-type, core,IPR003960:ATPase, AAA-type, conserved site,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00382:AAA, Acetylation,Alternative splicing,ATP-binding,Complete proteome,Cytoplasm,Nucleotide-binding,Polymorphism,Proteomics identification,Reference proteome,Repeat, chain:Spermatogenesis-associated protein 5-like protein 1,nucleotide phosphate-binding region:ATP 1,nucleotide phosphate-binding region:ATP 2,sequence conflict,sequence variant,splice variant, Q9R0A3 spermatogenesis associated 7(Spata7) Rattus norvegicus GO:0007283~spermatogenesis,GO:0045494~photoreceptor cell maintenance,GO:1903546~protein localization to photoreceptor outer segment,GO:1903621~protein localization to photoreceptor connecting cilium, GO:0005737~cytoplasm,GO:0005930~axoneme,GO:0015630~microtubule cytoskeleton,GO:0032391~photoreceptor connecting cilium,GO:0036064~ciliary basal body, Cell projection,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Reference proteome, chain:Spermatogenesis-associated protein 7 homolog, Q6DF94 spindle and centriole associated protein 1 L homeolog(spice1.L) Xenopus laevis GO:0046599~regulation of centriole replication,GO:0051301~cell division,GO:0090307~mitotic spindle assembly, GO:0005814~centriole,GO:0005819~spindle, Cell cycle,Cell division,Coiled coil,Cytoplasm,Cytoskeleton,Mitosis, chain:Coiled-coil domain-containing protein 52, O57683 splicing factor 3b subunit 1 S homeolog(sf3b1.S) Xenopus laevis RNA processing and modification, GO:0006397~mRNA processing,GO:0008380~RNA splicing, GO:0005681~spliceosomal complex, IPR011989:Armadillo-like helical,IPR015016:Splicing factor 3B subunit 1,IPR016024:Armadillo-type fold, xla03040:Spliceosome, mRNA processing,mRNA splicing,Nucleus,Repeat,Spliceosome, chain:Splicing factor 3B subunit 1,repeat:HEAT 1,repeat:HEAT 10,repeat:HEAT 11,repeat:HEAT 2,repeat:HEAT 3,repeat:HEAT 4,repeat:HEAT 5,repeat:HEAT 6,repeat:HEAT 7,repeat:HEAT 8,repeat:HEAT 9, O75533 splicing factor 3b subunit 1(SF3B1) Homo sapiens RNA processing and modification, GO:0000245~spliceosomal complex assembly,GO:0000375~RNA splicing, via transesterification reactions,GO:0000398~mRNA splicing, via spliceosome,GO:0045815~positive regulation of gene expression, epigenetic, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005681~spliceosomal complex,GO:0005686~U2 snRNP,GO:0005689~U12-type spliceosomal complex,GO:0016607~nuclear speck,GO:0034693~U11/U12 snRNP,GO:0071004~U2-type prespliceosome,GO:0071013~catalytic step 2 spliceosome, GO:0003729~mRNA binding,GO:0005515~protein binding,GO:0044822~poly(A) RNA binding, IPR011989:Armadillo-like helical,IPR015016:Splicing factor 3B subunit 1,IPR016024:Armadillo-type fold, hsa03040:Spliceosome, 614286~Myelodysplastic syndrome, somatic, 3D-structure,Acetylation,Alternative splicing,Citrullination,Coiled coil,Complete proteome,Isopeptide bond,mRNA processing,mRNA splicing,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Spliceosome,Ubl conjugation, chain:Splicing factor 3B subunit 1,helix,modified residue,mutagenesis site,region of interest:Interaction with PPP1R8,region of interest:Interaction with SF3B14,repeat:HEAT 1,repeat:HEAT 10,repeat:HEAT 11,repeat:HEAT 2,repeat:HEAT 3,repeat:HEAT 4,repeat:HEAT 5,repeat:HEAT 6,repeat:HEAT 7,repeat:HEAT 8,repeat:HEAT 9,sequence conflict,strand, Q8SX83 split ends(spen) Drosophila melanogaster GO:0000398~mRNA splicing, via spliceosome,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007173~epidermal growth factor receptor signaling pathway,GO:0007379~segment specification,GO:0007400~neuroblast fate determination,GO:0007403~glial cell fate determination,GO:0007411~axon guidance,GO:0007422~peripheral nervous system development,GO:0008347~glial cell migration,GO:0008586~imaginal disc-derived wing vein morphogenesis,GO:0016055~Wnt signaling pathway,GO:0030177~positive regulation of Wnt signaling pathway,GO:0030431~sleep,GO:0035222~wing disc pattern formation,GO:0035321~maintenance of imaginal disc-derived wing hair orientation,GO:0048106~establishment of thoracic bristle planar orientation,GO:0048749~compound eye development,GO:0050832~defense response to fungus, GO:0005634~nucleus, GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0003723~RNA binding, IPR000504:RNA recognition motif domain,IPR010912:Spen paralogue/orthologue C-terminal, metazoa,IPR012677:Nucleotide-binding, alpha-beta plait,IPR012921:Spen paralogue and orthologue SPOC, C-terminal,IPR016194:SPOC like C-terminal domain, SM00360:RRM, Alternative promoter usage,Alternative splicing,Coiled coil,Complete proteome,Developmental protein,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Repressor,RNA-binding,Transcription,Transcription regulation, chain:Protein split ends,compositionally biased region:Asn-rich,compositionally biased region:Gln-rich,compositionally biased region:Glu-rich,compositionally biased region:His-rich,compositionally biased region:Lys-rich,compositionally biased region:Pro-rich,compositionally biased region:Ser-rich,domain:RRM 1,domain:RRM 2,domain:RRM 3,domain:SPOC,modified residue,mutagenesis site,sequence conflict,splice variant, Q920G0 src kinase associated phosphoprotein 2(Skap2) Rattus norvegicus GO:0002757~immune response-activating signal transduction,GO:0008285~negative regulation of cell proliferation,GO:0009967~positive regulation of signal transduction,GO:0042113~B cell activation, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005886~plasma membrane, GO:0005070~SH3/SH2 adaptor activity, IPR001452:Src homology-3 domain,IPR001849:Pleckstrin homology domain,IPR011993:Pleckstrin homology-like domain, SM00233:PH,SM00326:SH3, B-cell activation,Complete proteome,Cytoplasm,Phosphoprotein,Reference proteome,SH3 domain, chain:Src kinase-associated phosphoprotein 2,domain:PH,domain:SH3,modified residue, Q3V1H9 sterile alpha motif domain containing 5(Samd5) Mus musculus IPR001660:Sterile alpha motif domain,IPR013761:Sterile alpha motif/pointed domain, SM00454:SAM, Complete proteome,Reference proteome, chain:Sterile alpha motif domain-containing protein 5,compositionally biased region:Poly-Ala,domain:SAM,sequence conflict, P91621 still life(sif) Drosophila melanogaster GO:0030036~actin cytoskeleton organization,GO:0035023~regulation of Rho protein signal transduction,GO:0035556~intracellular signal transduction,GO:0043087~regulation of GTPase activity,GO:0050770~regulation of axonogenesis,GO:0050803~regulation of synapse structure or activity,GO:0051491~positive regulation of filopodium assembly, GO:0005622~intracellular,GO:0030054~cell junction,GO:0045202~synapse, GO:0005057~receptor signaling protein activity,GO:0005089~Rho guanyl-nucleotide exchange factor activity,GO:0030676~Rac guanyl-nucleotide exchange factor activity, IPR000219:Dbl homology (DH) domain,IPR000697:EVH1,IPR001331:Guanine-nucleotide dissociation stimulator, CDC24, conserved site,IPR001478:PDZ domain,IPR001849:Pleckstrin homology domain,IPR003116:Raf-like Ras-binding,IPR011993:Pleckstrin homology-like domain, SM00228:PDZ,SM00233:PH,SM00325:RhoGEF,SM00455:RBD,SM00461:WH1, Alternative splicing,Cell junction,Complete proteome,Developmental protein,Guanine-nucleotide releasing factor,Lipoprotein,Myristate,Proteomics identification,Reference proteome,Repeat,Synapse, chain:Protein still life, isoform SIF type 1,chain:Protein still life, isoforms C/SIF type 2,compositionally biased region:Gln-rich,compositionally biased region:His-rich,domain:DH,domain:PDZ,domain:PH,domain:RBD,domain:WH1,lipid moiety-binding region:N-myristoyl glycine,region of interest:4 X 25 AA approximate repeats,repeat:1,repeat:2,repeat:3,repeat:4,sequence conflict,splice variant, A3KN83 strawberry notch homolog 1(SBNO1) Homo sapiens GO:0006355~regulation of transcription, DNA-templated, IPR026741:Protein strawberry notch-like,IPR026937:Strawberry notch, helicase C domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, Acetylation,Alternative splicing,Coiled coil,Complete proteome,Phosphoprotein,Polymorphism,Reference proteome, chain:Protein strawberry notch homolog 1,compositionally biased region:Poly-Lys,modified residue,sequence conflict,sequence variant,splice variant, Q9CU62 structural maintenance of chromosomes 1A(Smc1a) Mus musculus GO:0006281~DNA repair,GO:0006974~cellular response to DNA damage stimulus,GO:0007049~cell cycle,GO:0007062~sister chromatid cohesion,GO:0007064~mitotic sister chromatid cohesion,GO:0007067~mitotic nuclear division,GO:0007093~mitotic cell cycle checkpoint,GO:0007126~meiotic nuclear division,GO:0009314~response to radiation,GO:0019827~stem cell population maintenance,GO:0032876~negative regulation of DNA endoreduplication,GO:0042770~signal transduction in response to DNA damage,GO:0051276~chromosome organization,GO:0051301~cell division,GO:0051321~meiotic cell cycle, GO:0000775~chromosome, centromeric region,GO:0000776~kinetochore,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005694~chromosome,GO:0005737~cytoplasm,GO:0008278~cohesin complex,GO:0008280~cohesin core heterodimer,GO:0030893~meiotic cohesin complex, GO:0000166~nucleotide binding,GO:0003682~chromatin binding,GO:0005524~ATP binding,GO:0036033~mediator complex binding,GO:0044822~poly(A) RNA binding,GO:0046982~protein heterodimerization activity, IPR003395:RecF/RecN/SMC,IPR010935:SMCs flexible hinge,IPR024704:Structural maintenance of chromosomes protein,IPR027417:P-loop containing nucleoside triphosphate hydrolase, mmu04110:Cell cycle,mmu04114:Oocyte meiosis, PIRSF005719:structural maintenance of chromosomes protein, SM00968:SM00968, 3D-structure,Acetylation,ATP-binding,Cell cycle,Cell division,Centromere,Chromosome,Coiled coil,Complete proteome,DNA damage,DNA repair,Meiosis,Mitosis,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome, chain:Structural maintenance of chromosomes protein 1A,compositionally biased region:Ala/Asp-rich (DA-box),modified residue,nucleotide phosphate-binding region:ATP,region of interest:Flexible hinge,sequence conflict, Q8CG46 structural maintenance of chromosomes 5(Smc5) Mus musculus Cell division and chromosome partitioning, GO:0000722~telomere maintenance via recombination,GO:0000724~double-strand break repair via homologous recombination,GO:0006281~DNA repair,GO:0006310~DNA recombination,GO:0006974~cellular response to DNA damage stimulus,GO:0007049~cell cycle,GO:0007062~sister chromatid cohesion,GO:0007067~mitotic nuclear division,GO:0034184~positive regulation of maintenance of mitotic sister chromatid cohesion,GO:0045842~positive regulation of mitotic metaphase/anaphase transition,GO:0051301~cell division,GO:0051984~positive regulation of chromosome segregation,GO:0071139~resolution of recombination intermediates,GO:0090398~cellular senescence, GO:0000781~chromosome, telomeric region,GO:0000803~sex chromosome,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005694~chromosome,GO:0016605~PML body,GO:0030054~cell junction,GO:0030915~Smc5-Smc6 complex,GO:0035061~interchromatin granule,GO:0035861~site of double-strand break, GO:0000166~nucleotide binding,GO:0005524~ATP binding, IPR003395:RecF/RecN/SMC,IPR027131:Structural maintenance of chromosomes protein 5,IPR027417:P-loop containing nucleoside triphosphate hydrolase, Alternative splicing,ATP-binding,Cell cycle,Cell division,Chromosome,Coiled coil,Complete proteome,DNA damage,DNA recombination,DNA repair,Mitosis,Nucleotide-binding,Nucleus,Phosphoprotein,Reference proteome,Telomere,Ubl conjugation, chain:Structural maintenance of chromosomes protein 5,compositionally biased region:Ala/Asp-rich (DA-box),modified residue,nucleotide phosphate-binding region:ATP,region of interest:Flexible hinge,sequence conflict,splice variant, P53590 succinate-CoA ligase GDP-forming beta subunit(SUCLG2) Sus scrofa GO:0006099~tricarboxylic acid cycle,GO:0008152~metabolic process, GO:0005634~nucleus,GO:0005739~mitochondrion,GO:0005815~microtubule organizing center,GO:0005886~plasma membrane, GO:0004776~succinate-CoA ligase (GDP-forming) activity,GO:0005524~ATP binding,GO:0005525~GTP binding,GO:0016874~ligase activity, IPR005809:Succinyl-CoA synthetase, beta subunit,IPR005811:ATP-citrate lyase/succinyl-CoA ligase,IPR013650:ATP-grasp fold, succinyl-CoA synthetase-type,IPR013815:ATP-grasp fold, subdomain 1,IPR013816:ATP-grasp fold, subdomain 2,IPR016102:Succinyl-CoA synthetase-like,IPR017866:Succinyl-CoA synthetase, beta subunit, conserved site, ssc00020:Citrate cycle (TCA cycle),ssc00640:Propanoate metabolism,ssc01100:Metabolic pathways,ssc01130:Biosynthesis of antibiotics,ssc01200:Carbon metabolism, PIRSF001554:succinyl-CoA synthetase, beta subunit, 3D-structure,Acetylation,Complete proteome,Direct protein sequencing,GTP-binding,Ligase,Mitochondrion,Nucleotide-binding,Phosphoprotein,Proteomics identification,Reference proteome,Transit peptide,Tricarboxylic acid cycle, chain:Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial,domain:ATP-grasp,helix,modified residue,strand,transit peptide:Mitochondrion,turn, O02373 sugarless(sgl) Drosophila melanogaster Cell envelope biogenesis, outer membrane, GO:0002121~inter-male aggressive behavior,GO:0005975~carbohydrate metabolic process,GO:0006024~glycosaminoglycan biosynthetic process,GO:0006065~UDP-glucuronate biosynthetic process,GO:0007166~cell surface receptor signaling pathway,GO:0007224~smoothened signaling pathway,GO:0007367~segment polarity determination,GO:0007427~epithelial cell migration, open tracheal system,GO:0007428~primary branching, open tracheal system,GO:0007476~imaginal disc-derived wing morphogenesis,GO:0007507~heart development,GO:0007509~mesoderm migration involved in gastrulation,GO:0008543~fibroblast growth factor receptor signaling pathway,GO:0015012~heparan sulfate proteoglycan biosynthetic process,GO:0015014~heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process,GO:0016055~Wnt signaling pathway,GO:0016319~mushroom body development,GO:0030206~chondroitin sulfate biosynthetic process,GO:0042048~olfactory behavior,GO:0055114~oxidation-reduction process, GO:0005634~nucleus,GO:0005829~cytosol, GO:0003979~UDP-glucose 6-dehydrogenase activity,GO:0016616~oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor,GO:0051287~NAD binding, IPR001732:UDP-glucose/GDP-mannose dehydrogenase, N-terminal,IPR008927:6-phosphogluconate dehydrogenase, C-terminal-like,IPR014026:UDP-glucose/GDP-mannose dehydrogenase, dimerisation,IPR014027:UDP-glucose/GDP-mannose dehydrogenase, C-terminal,IPR016040:NAD(P)-binding domain,IPR017476:Nucleotide sugar dehydrogenase, dme00040:Pentose and glucuronate interconversions,dme00053:Ascorbate and aldarate metabolism,dme00520:Amino sugar and nucleotide sugar metabolism,dme01100:Metabolic pathways, PIRSF000124:UDP-glucose/GDP-mannose dehydrogenase,PIRSF500133:UDP-glucose 6-dehydrogenase, eukaryotic type [Parent=PIRSF000124], SM00984:SM00984, Complete proteome,NAD,Oxidoreductase,Reference proteome,Wnt signaling pathway, active site:Nucleophile,binding site:NAD,binding site:Substrate,chain:UDP-glucose 6-dehydrogenase,nucleotide phosphate-binding region:NAD,region of interest:Substrate binding,sequence conflict, Q8BPG6 sulfatase modifying factor 2(Sumf2) Mus musculus GO:0005783~endoplasmic reticulum,GO:0005788~endoplasmic reticulum lumen, GO:0005515~protein binding,GO:0042803~protein homodimerization activity,GO:0046872~metal ion binding, IPR005532:Formylglycine-generating sulphatase enzyme domain,IPR016187:C-type lectin fold, Calcium,Complete proteome,Disulfide bond,Endoplasmic reticulum,Glycoprotein,Metal-binding,Proteomics identification,Reference proteome,Signal, chain:Sulfatase-modifying factor 2,disulfide bond,glycosylation site:N-linked (GlcNAc...),metal ion-binding site:Calcium 1,metal ion-binding site:Calcium 1; via carbonyl oxygen,metal ion-binding site:Calcium 2,metal ion-binding site:Calcium 2; via carbonyl oxygen,sequence conflict,signal peptide, Q5ZM71 suppressor of Ty 20 homolog (S. cerevisiae)(SUPT20H) Gallus gallus GO:0007369~gastrulation,GO:0035948~positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter,GO:1903506~regulation of nucleic acid-templated transcription, GO:0000124~SAGA complex, GO:0003712~transcription cofactor activity, IPR021950:Transcription factor Spt20, Complete proteome,Developmental protein,Gastrulation,Reference proteome, chain:Protein FAM48A,compositionally biased region:Poly-Pro,compositionally biased region:Poly-Ser, O14544 suppressor of cytokine signaling 6(SOCS6) Homo sapiens GO:0006469~negative regulation of protein kinase activity,GO:0006952~defense response,GO:0007259~JAK-STAT cascade,GO:0010498~proteasomal protein catabolic process,GO:0016567~protein ubiquitination,GO:0019221~cytokine-mediated signaling pathway,GO:0035556~intracellular signal transduction,GO:0040008~regulation of growth,GO:0046426~negative regulation of JAK-STAT cascade,GO:0050868~negative regulation of T cell activation, GO:0001772~immunological synapse,GO:0005622~intracellular,GO:0005737~cytoplasm, GO:0004860~protein kinase inhibitor activity,GO:0005515~protein binding, IPR000980:SH2 domain,IPR001496:SOCS protein, C-terminal, SM00252:SH2,SM00253:SOCS,SM00969:SM00969, 3D-structure,Complete proteome,Growth regulation,Proteomics identification,Reference proteome,SH2 domain,Signal transduction inhibitor,Ubl conjugation pathway, chain:Suppressor of cytokine signaling 6,compositionally biased region:Poly-Ser,domain:SH2,domain:SOCS box,helix,modified residue,sequence conflict,strand,turn, Q8CHC4 synaptojanin 1(Synj1) Mus musculus m_ndkDynaminPathway:Endocytotic role of NDK, Phosphins and Dynamin, GO:0006836~neurotransmitter transport,GO:0007420~brain development,GO:0007612~learning,GO:0014015~positive regulation of gliogenesis,GO:0016082~synaptic vesicle priming,GO:0016191~synaptic vesicle uncoating,GO:0032526~response to retinoic acid,GO:0034097~response to cytokine,GO:0046488~phosphatidylinositol metabolic process,GO:0046855~inositol phosphate dephosphorylation,GO:0046856~phosphatidylinositol dephosphorylation,GO:0048015~phosphatidylinositol-mediated signaling,GO:0048260~positive regulation of receptor-mediated endocytosis,GO:0048488~synaptic vesicle endocytosis,GO:0048489~synaptic vesicle transport,GO:1903423~positive regulation of synaptic vesicle recycling,GO:1904980~positive regulation of endosome organization, GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005874~microtubule,GO:0012506~vesicle membrane,GO:0030117~membrane coat,GO:0030118~clathrin coat,GO:0030132~clathrin coat of coated pit,GO:0043005~neuron projection,GO:0043195~terminal bouton,GO:0043234~protein complex,GO:0097060~synaptic membrane,GO:0098793~presynapse, GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0003723~RNA binding,GO:0004438~phosphatidylinositol-3-phosphatase activity,GO:0004439~phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity,GO:0005515~protein binding,GO:0008022~protein C-terminus binding,GO:0017124~SH3 domain binding,GO:0032403~protein complex binding,GO:0034595~phosphatidylinositol phosphate 5-phosphatase activity,GO:0042578~phosphoric ester hydrolase activity,GO:0043812~phosphatidylinositol-4-phosphate phosphatase activity, IPR000300:Inositol polyphosphate-related phosphatase,IPR000504:RNA recognition motif domain,IPR002013:Synaptojanin, N-terminal,IPR005135:Endonuclease/exonuclease/phosphatase,IPR012677:Nucleotide-binding, alpha-beta plait,IPR015047:Domain of unknown function DUF1866, mmu00562:Inositol phosphate metabolism,mmu01100:Metabolic pathways,mmu04070:Phosphatidylinositol signaling system, SM00128:IPPc,SM01165:SM01165, Complete proteome,Cytoplasm,Endocytosis,Hydrolase,Methylation,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,RNA-binding, chain:Synaptojanin-1,compositionally biased region:Pro-rich,domain:RRM,domain:SAC,modified residue, Q3T0C9 synaptojanin 2 binding protein(SYNJ2BP) Bos taurus GO:0001937~negative regulation of endothelial cell proliferation,GO:0002092~positive regulation of receptor internalization,GO:0006605~protein targeting,GO:0006897~endocytosis,GO:0007266~Rho protein signal transduction,GO:0008593~regulation of Notch signaling pathway,GO:0010596~negative regulation of endothelial cell migration,GO:0016525~negative regulation of angiogenesis,GO:0032926~negative regulation of activin receptor signaling pathway,GO:0032927~positive regulation of activin receptor signaling pathway,GO:0070373~negative regulation of ERK1 and ERK2 cascade,GO:1903671~negative regulation of sprouting angiogenesis,GO:2000010~positive regulation of protein localization to cell surface, GO:0005739~mitochondrion,GO:0005741~mitochondrial outer membrane,GO:0009986~cell surface,GO:0016021~integral component of membrane,GO:0048471~perinuclear region of cytoplasm, IPR001478:PDZ domain, SM00228:PDZ, Complete proteome,Cytoplasm,Endocytosis,Membrane,Mitochondrion,Mitochondrion outer membrane,Reference proteome,Signal-anchor,Transmembrane,Transmembrane helix, chain:Synaptojanin-2-binding protein,domain:PDZ,topological domain:Cytoplasmic,topological domain:Mitochondrial intermembrane,transmembrane region, Q99L88 syntrophin, basic 1(Sntb1) Mus musculus GO:0005737~cytoplasm,GO:0005856~cytoskeleton,GO:0005886~plasma membrane,GO:0005925~focal adhesion,GO:0016020~membrane,GO:0030054~cell junction,GO:0042383~sarcolemma,GO:0043234~protein complex,GO:0045202~synapse, GO:0003779~actin binding,GO:0005198~structural molecule activity,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0030165~PDZ domain binding, IPR001478:PDZ domain,IPR001849:Pleckstrin homology domain,IPR011993:Pleckstrin homology-like domain,IPR015482:Syntrophin, SM00228:PDZ,SM00233:PH, Acetylation,Actin-binding,Alternative splicing,Calcium,Calmodulin-binding,Cell junction,Cell membrane,Complete proteome,Cytoplasm,Cytoskeleton,Membrane,Phosphoprotein,Reference proteome,Repeat, chain:Beta-1-syntrophin,compositionally biased region:Poly-Ala,compositionally biased region:Poly-Gly,domain:PDZ,domain:PH 1,domain:PH 2,domain:SU,modified residue,region of interest:Calmodulin-binding,splice variant, Q8IZ69 tRNA methyltransferase 2 homolog A(TRMT2A) Homo sapiens General function prediction only,Translation, ribosomal structure and biogenesis, GO:0001510~RNA methylation,GO:0006396~RNA processing, GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0008173~RNA methyltransferase activity,GO:0044822~poly(A) RNA binding, IPR000504:RNA recognition motif domain,IPR010280:(Uracil-5)-methyltransferase,IPR012677:Nucleotide-binding, alpha-beta plait,IPR025714:Methyltransferase domain, Alternative splicing,Coiled coil,Complete proteome,Methyltransferase,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,RNA-binding,S-adenosyl-L-methionine,Transferase, chain:tRNA (uracil-5-)-methyltransferase homolog A,compositionally biased region:Poly-Arg,domain:RRM,modified residue,sequence conflict,sequence variant,splice variant, Q80VC6 tRNA selenocysteine 1 associated protein 1(Trnau1ap) Mus musculus GO:0001514~selenocysteine incorporation,GO:0006412~translation, GO:0005634~nucleus,GO:0005737~cytoplasm, GO:0000049~tRNA binding,GO:0000166~nucleotide binding,GO:0003676~nucleic acid binding,GO:0003723~RNA binding,GO:0005515~protein binding,GO:0044822~poly(A) RNA binding, IPR000504:RNA recognition motif domain,IPR012677:Nucleotide-binding, alpha-beta plait, SM00360:RRM, Complete proteome,Cytoplasm,Nucleus,Protein biosynthesis,Proteomics identification,Reference proteome,Repeat,RNA-binding, chain:tRNA selenocysteine 1-associated protein 1,compositionally biased region:Tyr-rich,domain:RRM 1,domain:RRM 2,sequence conflict, Q9VBP3 tankyrase(Tnks) Drosophila melanogaster General function prediction only, GO:0006471~protein ADP-ribosylation,GO:0022416~chaeta development,GO:0035220~wing disc development,GO:0090364~regulation of proteasome assembly, GO:0003950~NAD+ ADP-ribosyltransferase activity,GO:0046872~metal ion binding,GO:0097110~scaffold protein binding, IPR001660:Sterile alpha motif domain,IPR002110:Ankyrin repeat,IPR012317:Poly(ADP-ribose) polymerase, catalytic domain,IPR013761:Sterile alpha motif/pointed domain,IPR020683:Ankyrin repeat-containing domain, SM00248:ANK,SM00454:SAM, ANK repeat,Complete proteome,Glycosyltransferase,Metal-binding,NAD,Reference proteome,Repeat,Transferase,Zinc, P42680 tec protein tyrosine kinase(TEC) Homo sapiens GO:0002250~adaptive immune response,GO:0006468~protein phosphorylation,GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway,GO:0007229~integrin-mediated signaling pathway,GO:0010543~regulation of platelet activation,GO:0018108~peptidyl-tyrosine phosphorylation,GO:0030154~cell differentiation,GO:0035556~intracellular signal transduction,GO:0038083~peptidyl-tyrosine autophosphorylation,GO:0038095~Fc-epsilon receptor signaling pathway,GO:0042127~regulation of cell proliferation,GO:0042246~tissue regeneration,GO:0045087~innate immune response,GO:0050731~positive regulation of peptidyl-tyrosine phosphorylation,GO:0050853~B cell receptor signaling pathway, GO:0005829~cytosol,GO:0005856~cytoskeleton,GO:0031234~extrinsic component of cytoplasmic side of plasma membrane, GO:0004715~non-membrane spanning protein tyrosine kinase activity,GO:0005102~receptor binding,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0005543~phospholipid binding,GO:0046872~metal ion binding, IPR000719:Protein kinase, catalytic domain,IPR000980:SH2 domain,IPR001245:Serine-threonine/tyrosine-protein kinase catalytic domain,IPR001452:Src homology-3 domain,IPR001562:Zinc finger, Btk motif,IPR001849:Pleckstrin homology domain,IPR008266:Tyrosine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR011993:Pleckstrin homology-like domain,IPR017441:Protein kinase, ATP binding site,IPR020635:Tyrosine-protein kinase, catalytic domain, hsa04380:Osteoclast differentiation,hsa04660:T cell receptor signaling pathway, SM00107:BTK,SM00219:TyrKc,SM00233:PH,SM00252:SH2,SM00326:SH3, 3D-structure,Adaptive immunity,ATP-binding,Cell membrane,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Immunity,Kinase,Lipid-binding,Membrane,Metal-binding,Nucleotide-binding,Phosphoprotein,Polymorphism,Reference proteome,SH2 domain,SH3 domain,Transferase,Tyrosine-protein kinase,Zinc,Zinc-finger, active site:Proton acceptor,binding site:ATP,chain:Tyrosine-protein kinase Tec,domain:PH,domain:Protein kinase,domain:SH2,domain:SH3,metal ion-binding site:Zinc,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,sequence variant,zinc finger region:Btk-type, Q4R9E0 tectonic family member 3(TCTN3) Macaca fascicularis GO:0006915~apoptotic process,GO:0007224~smoothened signaling pathway,GO:0060271~cilium morphogenesis, GO:0016021~integral component of membrane, IPR011677:Domain of unknown function DUF1619, Apoptosis,Cilium biogenesis/degradation,Glycoprotein,Membrane,Signal,Transmembrane,Transmembrane helix, Q6NUS6 tectonic family member 3(TCTN3) Homo sapiens GO:0006915~apoptotic process,GO:0007224~smoothened signaling pathway,GO:0060271~cilium morphogenesis, GO:0016021~integral component of membrane,GO:0060170~ciliary membrane,GO:0070062~extracellular exosome, IPR011677:Domain of unknown function DUF1619, 258860~Orofaciodigital syndrome IV,614815~Joubert syndrome 18, Alternative splicing,Apoptosis,Ciliopathy,Cilium biogenesis/degradation,Complete proteome,Disease mutation,Glycoprotein,Joubert syndrome,Membrane,Proteomics identification,Reference proteome,Signal,Transmembrane,Transmembrane helix, chain:Tectonic-3,compositionally biased region:Cys-rich,glycosylation site:N-linked (GlcNAc...),sequence conflict,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q9D494 telomere repeat binding bouquet formation protein 2(Terb2) Mus musculus GO:0007129~synapsis,GO:0045141~meiotic telomere clustering,GO:0051321~meiotic cell cycle,GO:0070197~meiotic attachment of telomere to nuclear envelope, GO:0000781~chromosome, telomeric region,GO:0000784~nuclear chromosome, telomeric region,GO:0005634~nucleus,GO:0005637~nuclear inner membrane,GO:0005694~chromosome,GO:0016020~membrane, Chromosome,Complete proteome,Meiosis,Membrane,Nucleus,Reference proteome,Telomere, chain:Uncharacterized protein C15orf43 homolog, Q6NYJ3 telomeric repeat binding factor 2, interacting protein(terf2ip) Danio rerio GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0010569~regulation of double-strand break repair via homologous recombination,GO:0010833~telomere maintenance via telomere lengthening,GO:0031848~protection from non-homologous end joining at telomere,GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB signaling,GO:0048239~negative regulation of DNA recombination at telomere,GO:0051092~positive regulation of NF-kappaB transcription factor activity, GO:0000781~chromosome, telomeric region,GO:0005634~nucleus,GO:0005694~chromosome,GO:0005737~cytoplasm, GO:0003677~DNA binding, IPR001357:BRCT domain,IPR009057:Homeodomain-like,IPR015010:Rap1 Myb domain,IPR021661:Rap1 - C-terminal, Activator,Alternative splicing,Chromosome,Complete proteome,Nucleus,Reference proteome,Telomere,Transcription,Transcription regulation, P22105 tenascin XB(TNXB) Homo sapiens GO:0007155~cell adhesion,GO:0030036~actin cytoskeleton organization,GO:0030199~collagen fibril organization,GO:0032963~collagen metabolic process,GO:0048251~elastic fiber assembly, GO:0005578~proteinaceous extracellular matrix,GO:0005583~fibrillar collagen trimer,GO:0005615~extracellular space,GO:0005622~intracellular,GO:0031012~extracellular matrix,GO:0070062~extracellular exosome, GO:0005178~integrin binding,GO:0005201~extracellular matrix structural constituent,GO:0005515~protein binding,GO:0008201~heparin binding, IPR000742:Epidermal growth factor-like domain,IPR002181:Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain,IPR003961:Fibronectin, type III,IPR013032:EGF-like, conserved site,IPR013111:EGF, extracellular,IPR013783:Immunoglobulin-like fold,IPR014715:Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2,IPR014716:Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1,IPR020837:Fibrinogen, conserved site, hsa04151:PI3K-Akt signaling pathway,hsa04510:Focal adhesion,hsa04512:ECM-receptor interaction,hsa05206:MicroRNAs in cancer, 606408~Ehlers-Danlos syndrome due to tenascin X deficiency,615963~Vesicoureteral reflux 8, SM00060:FN3,SM00181:EGF,SM00186:FBG, 3D-structure,Alternative splicing,Cell adhesion,Coiled coil,Complete proteome,Direct protein sequencing,Disease mutation,Disulfide bond,EGF-like domain,Ehlers-Danlos syndrome,Extracellular matrix,Glycoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Secreted,Signal, chain:Putative tenascin-XA,chain:Tenascin-X,disulfide bond,domain:EGF-like 10,domain:EGF-like 11,domain:EGF-like 12,domain:EGF-like 13,domain:EGF-like 14,domain:EGF-like 15,domain:EGF-like 16,domain:EGF-like 17,domain:EGF-like 18,domain:EGF-like 19,domain:EGF-like 1; incomplete,domain:EGF-like 2,domain:EGF-like 3,domain:EGF-like 4,domain:EGF-like 5,domain:EGF-like 6,domain:EGF-like 7,domain:EGF-like 8,domain:EGF-like 9,domain:Fibrinogen C-terminal,domain:Fibronectin type-III 1,domain:Fibronectin type-III 10,domain:Fibronectin type-III 11,domain:Fibronectin type-III 12,domain:Fibronectin type-III 13,domain:Fibronectin type-III 14,domain:Fibronectin type-III 15,domain:Fibronectin type-III 16,domain:Fibronectin type-III 17,domain:Fibronectin type-III 18,domain:Fibronectin type-III 19,domain:Fibronectin type-III 2,domain:Fibronectin type-III 20,domain:Fibronectin type-III 21,domain:Fibronectin type-III 22,domain:Fibronectin type-III 23,domain:Fibronectin type-III 24,domain:Fibronectin type-III 25,domain:Fibronectin type-III 26,domain:Fibronectin type-III 27,domain:Fibronectin type-III 28,domain:Fibronectin type-III 29,domain:Fibronectin type-III 3,domain:Fibronectin type-III 30,domain:Fibronectin type-III 31,domain:Fibronectin type-III 32,domain:Fibronectin type-III 4,domain:Fibronectin type-III 5,domain:Fibronectin type-III 6,domain:Fibronectin type-III 7,domain:Fibronectin type-III 8,domain:Fibronectin type-III 9,glycosylation site:N-linked (GlcNAc...),modified residue,sequence conflict,sequence variant,short sequence motif:Cell attachment site,signal peptide,splice variant,strand,turn, Q9D845 testis expressed gene 9(Tex9) Mus musculus Alternative splicing,Coiled coil,Complete proteome,Proteomics identification,Reference proteome, chain:Testis-expressed sequence 9 protein,splice variant, Q6N021 tet methylcytosine dioxygenase 2(TET2) Homo sapiens GO:0001822~kidney development,GO:0002318~myeloid progenitor cell differentiation,GO:0006211~5-methylcytosine catabolic process,GO:0006493~protein O-linked glycosylation,GO:0007049~cell cycle,GO:0009791~post-embryonic development,GO:0014070~response to organic cyclic compound,GO:0019511~peptidyl-proline hydroxylation,GO:0019857~5-methylcytosine metabolic process,GO:0019858~cytosine metabolic process,GO:0020027~hemoglobin metabolic process,GO:0030099~myeloid cell differentiation,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0048536~spleen development,GO:0061484~hematopoietic stem cell homeostasis,GO:0070989~oxidative demethylation,GO:0072576~liver morphogenesis,GO:0080111~DNA demethylation,GO:0080182~histone H3-K4 trimethylation, GO:0005634~nucleus, GO:0000907~sulfonate dioxygenase activity,GO:0003677~DNA binding,GO:0005515~protein binding,GO:0008198~ferrous iron binding,GO:0008270~zinc ion binding,GO:0018602~2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity,GO:0019798~procollagen-proline dioxygenase activity,GO:0034792~hypophosphite dioxygenase activity,GO:0043734~DNA-N1-methyladenine dioxygenase activity,GO:0052634~C-19 gibberellin 2-beta-dioxygenase activity,GO:0052635~C-20 gibberellin 2-beta-dioxygenase activity,GO:0070579~methylcytosine dioxygenase activity, IPR024779:2OGFeDO domain, nucleic acid-modifying type, 614286~Myelodysplastic syndrome, somatic, SM01333:SM01333, 3D-structure,Alternative splicing,Cell cycle,Chromatin regulator,Complete proteome,Dioxygenase,DNA-binding,Glycoprotein,Iron,Metal-binding,Methylation,Oxidoreductase,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Tumor suppressor,Zinc, binding site:2-oxoglutarate,chain:Probable methylcytosine dioxygenase TET2,compositionally biased region:Gln-rich,compositionally biased region:Pro-rich,metal ion-binding site:Iron; catalytic,modified residue,sequence conflict,sequence variant,splice variant, O15050 tetratricopeptide repeat and ankyrin repeat containing 1(TRANK1) Homo sapiens IPR002110:Ankyrin repeat,IPR011990:Tetratricopeptide-like helical,IPR013026:Tetratricopeptide repeat-containing domain,IPR019734:Tetratricopeptide repeat,IPR020683:Ankyrin repeat-containing domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00028:TPR,SM00248:ANK, ANK repeat,Coiled coil,Complete proteome,Polymorphism,Reference proteome,Repeat,Signal,TPR repeat, chain:Lupus brain antigen 1 homolog,compositionally biased region:Glu-rich,repeat:ANK 1,repeat:ANK 2,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5,repeat:ANK 6,repeat:TPR 1,repeat:TPR 2,repeat:TPR 3,repeat:TPR 4,sequence conflict,sequence variant, Q96AY4 tetratricopeptide repeat domain 28(TTC28) Homo sapiens GO:0007067~mitotic nuclear division,GO:0007346~regulation of mitotic cell cycle,GO:0051301~cell division, GO:0000922~spindle pole,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0030496~midbody, IPR011990:Tetratricopeptide-like helical,IPR013026:Tetratricopeptide repeat-containing domain,IPR019734:Tetratricopeptide repeat,IPR024983:CHAT domain, SM00028:TPR, Acetylation,Cell cycle,Cell division,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Mitosis,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,TPR repeat, chain:Tetratricopeptide repeat protein 28,chain:UPF0463 transmembrane protein C6orf35,compositionally biased region:Ser-rich,modified residue,repeat:TPR 1,repeat:TPR 10,repeat:TPR 11,repeat:TPR 12,repeat:TPR 13,repeat:TPR 14,repeat:TPR 15,repeat:TPR 16,repeat:TPR 17,repeat:TPR 18,repeat:TPR 19,repeat:TPR 2,repeat:TPR 20,repeat:TPR 21,repeat:TPR 22,repeat:TPR 23,repeat:TPR 24,repeat:TPR 25,repeat:TPR 26,repeat:TPR 27,repeat:TPR 28,repeat:TPR 3,repeat:TPR 4,repeat:TPR 5,repeat:TPR 6,repeat:TPR 7,repeat:TPR 8,repeat:TPR 9,transmembrane region, Q6INU8 tetratricopeptide repeat domain 30a S homeolog(ttc30a.S) Xenopus laevis GO:0018095~protein polyglutamylation,GO:0042073~intraciliary transport, GO:0005879~axonemal microtubule,GO:0005929~cilium, GO:0005215~transporter activity, IPR011990:Tetratricopeptide-like helical,IPR013026:Tetratricopeptide repeat-containing domain,IPR019734:Tetratricopeptide repeat, SM00028:TPR, Cell projection,Cilium,Cilium biogenesis/degradation,Coiled coil,Repeat,TPR repeat, chain:Tetratricopeptide repeat protein 30,compositionally biased region:Poly-Leu,repeat:TPR 1,repeat:TPR 2,repeat:TPR 3,repeat:TPR 4,repeat:TPR 5,repeat:TPR 6,repeat:TPR 7,repeat:TPR 8, Q6PGP7 tetratricopeptide repeat domain 37(TTC37) Homo sapiens GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0035327~transcriptionally active chromatin,GO:0055087~Ski complex, GO:0005515~protein binding, IPR006597:Sel1-like,IPR011990:Tetratricopeptide-like helical,IPR013026:Tetratricopeptide repeat-containing domain,IPR019734:Tetratricopeptide repeat, hsa03018:RNA degradation, 222470~Trichohepatoenteric syndrome 1, SM00028:TPR, Acetylation,Complete proteome,Cytoplasm,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Repeat,TPR repeat, chain:Tetratricopeptide repeat protein 37,repeat:TPR 1,repeat:TPR 10,repeat:TPR 11,repeat:TPR 12,repeat:TPR 13,repeat:TPR 14,repeat:TPR 15,repeat:TPR 16,repeat:TPR 17,repeat:TPR 18,repeat:TPR 19,repeat:TPR 2,repeat:TPR 20,repeat:TPR 3,repeat:TPR 4,repeat:TPR 5,repeat:TPR 6,repeat:TPR 7,repeat:TPR 8,repeat:TPR 9,sequence variant, Q8K2W3 thioredoxin domain containing 11(Txndc11) Mus musculus GO:0006457~protein folding,GO:0034976~response to endoplasmic reticulum stress,GO:0045454~cell redox homeostasis, GO:0005623~cell,GO:0005783~endoplasmic reticulum,GO:0005789~endoplasmic reticulum membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0003756~protein disulfide isomerase activity, IPR012336:Thioredoxin-like fold,IPR013766:Thioredoxin domain, Alternative splicing,Coiled coil,Complete proteome,Disulfide bond,Endoplasmic reticulum,Membrane,Phosphoprotein,Proteomics identification,Redox-active center,Reference proteome,Repeat,Transmembrane,Transmembrane helix, chain:Thioredoxin domain-containing protein 11,disulfide bond,domain:Thioredoxin 1,domain:Thioredoxin 2,modified residue,splice variant,transmembrane region, Q91W90 thioredoxin domain containing 5(Txndc5) Mus musculus GO:0006457~protein folding,GO:0034976~response to endoplasmic reticulum stress,GO:0043277~apoptotic cell clearance,GO:0045454~cell redox homeostasis, GO:0005623~cell,GO:0005783~endoplasmic reticulum,GO:0005788~endoplasmic reticulum lumen,GO:0070062~extracellular exosome, GO:0003756~protein disulfide isomerase activity,GO:0016853~isomerase activity, IPR005788:Disulphide isomerase,IPR012336:Thioredoxin-like fold,IPR013766:Thioredoxin domain,IPR017937:Thioredoxin, conserved site, mmu04141:Protein processing in endoplasmic reticulum, Complete proteome,Direct protein sequencing,Disulfide bond,Endoplasmic reticulum,Proteomics identification,Redox-active center,Reference proteome,Repeat,Signal, chain:Thioredoxin domain-containing protein 5,disulfide bond,domain:Thioredoxin 1,domain:Thioredoxin 2,domain:Thioredoxin 3,sequence conflict,short sequence motif:Prevents secretion from ER,signal peptide, Q5R5P3 threonine synthase like 1(THNSL1) Pongo abelii GO:0005654~nucleoplasm,GO:0005739~mitochondrion, IPR000623:Shikimate kinase/Threonine synthase-like 1,IPR001926:Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily,IPR004450:Threonine synthase-like,IPR027417:P-loop containing nucleoside triphosphate hydrolase, Acetylation,Complete proteome,Pyridoxal phosphate,Reference proteome, chain:Threonine synthase-like 1,modified residue, P49746 thrombospondin 3(THBS3) Homo sapiens GO:0003417~growth plate cartilage development,GO:0007155~cell adhesion,GO:0007160~cell-matrix adhesion,GO:0043931~ossification involved in bone maturation,GO:0060346~bone trabecula formation, GO:0005576~extracellular region,GO:0048471~perinuclear region of cytoplasm, GO:0005509~calcium ion binding,GO:0008201~heparin binding, IPR000742:Epidermal growth factor-like domain,IPR001791:Laminin G domain,IPR001881:EGF-like calcium-binding,IPR003367:Thrombospondin, type 3-like repeat,IPR008859:Thrombospondin, C-terminal,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR013032:EGF-like, conserved site,IPR013320:Concanavalin A-like lectin/glucanase, subgroup,IPR017897:Thrombospondin, type 3 repeat,IPR018097:EGF-like calcium-binding, conserved site,IPR024665:Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain, hsa04145:Phagosome,hsa04151:PI3K-Akt signaling pathway,hsa04510:Focal adhesion,hsa04512:ECM-receptor interaction,hsa05144:Malaria, SM00179:EGF_CA,SM00181:EGF,SM00210:TSPN, Alternative splicing,Calcium,Cell adhesion,Complete proteome,Disulfide bond,EGF-like domain,Glycoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Signal, chain:Thrombospondin-3,disulfide bond,domain:EGF-like 1,domain:EGF-like 2; calcium-binding,domain:EGF-like 3; calcium-binding,domain:EGF-like 4,domain:TSP C-terminal,domain:TSP N-terminal,glycosylation site:N-linked (GlcNAc...),modified residue,repeat:TSP type-3 1,repeat:TSP type-3 2,repeat:TSP type-3 3,repeat:TSP type-3 4,repeat:TSP type-3 5,repeat:TSP type-3 6,repeat:TSP type-3 7,repeat:TSP type-3 8,sequence variant,signal peptide, Q8BUZ3 tigger transposable element derived 4(Tigd4) Mus musculus GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding, IPR004875:DDE superfamily endonuclease, CENP-B-like,IPR006600:HTH CenpB-type DNA-binding domain,IPR007889:DNA binding HTH domain, Psq-type,IPR009057:Homeodomain-like, SM00674:CENPB, Complete proteome,DNA-binding,Nucleus,Reference proteome, chain:Tigger transposable element-derived protein 4,DNA-binding region:H-T-H motif,domain:DDE,domain:HTH CENPB-type,domain:HTH psq-type,modified residue, Q07157 tight junction protein 1(TJP1) Homo sapiens GO:0001825~blastocyst formation,GO:0007043~cell-cell junction assembly,GO:0007605~sensory perception of sound,GO:0032496~response to lipopolysaccharide,GO:0035329~hippo signaling,GO:0042493~response to drug,GO:0043116~negative regulation of vascular permeability,GO:0045471~response to ethanol,GO:0071000~response to magnetism,GO:0071333~cellular response to glucose stimulus,GO:0090557~establishment of endothelial intestinal barrier,GO:0098609~cell-cell adhesion,GO:1901350~cell-cell signaling involved in cell-cell junction organization, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0005913~cell-cell adherens junction,GO:0005921~gap junction,GO:0005923~bicellular tight junction,GO:0014704~intercalated disc,GO:0016323~basolateral plasma membrane,GO:0016324~apical plasma membrane,GO:0016327~apicolateral plasma membrane,GO:0030054~cell junction,GO:0043296~apical junction complex,GO:0045177~apical part of cell,GO:0046581~intercellular canaliculus, GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0008022~protein C-terminus binding,GO:0019904~protein domain specific binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000906:ZU5,IPR001452:Src homology-3 domain,IPR001478:PDZ domain,IPR005417:Zona occludens protein,IPR005418:Zona occludens protein ZO-1,IPR008144:Guanylate kinase,IPR008145:Guanylate kinase/L-type calcium channel,IPR011511:Variant SH3,IPR027417:P-loop containing nucleoside triphosphate hydrolase, hsa04520:Adherens junction,hsa04530:Tight junction,hsa04540:Gap junction,hsa05110:Vibrio cholerae infection,hsa05120:Epithelial cell signaling in Helicobacter pylori infection,hsa05132:Salmonella infection, SM00072:GuKc,SM00218:ZU5,SM00228:PDZ, 3D-structure,Alternative splicing,Calmodulin-binding,Cell junction,Cell membrane,Complete proteome,Gap junction,Membrane,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,SH3 domain,Tight junction, chain:Tight junction protein ZO-1,compositionally biased region:Poly-Pro,domain:Guanylate kinase-like,domain:PDZ 1,domain:PDZ 2,domain:PDZ 3,domain:SH3,domain:ZU5,helix,modified residue,sequence conflict,sequence variant,splice variant,strand,turn, O97758 tight junction protein 1(TJP1) Canis lupus familiaris GO:0001825~blastocyst formation,GO:0007605~sensory perception of sound,GO:0070830~bicellular tight junction assembly,GO:0071277~cellular response to calcium ion,GO:0090557~establishment of endothelial intestinal barrier, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005886~plasma membrane,GO:0005911~cell-cell junction,GO:0005913~cell-cell adherens junction,GO:0005921~gap junction,GO:0005923~bicellular tight junction,GO:0009986~cell surface,GO:0014704~intercalated disc,GO:0016323~basolateral plasma membrane,GO:0016324~apical plasma membrane,GO:0016327~apicolateral plasma membrane,GO:0031410~cytoplasmic vesicle,GO:0046581~intercellular canaliculus, GO:0005515~protein binding,GO:0005516~calmodulin binding, IPR000906:ZU5,IPR001452:Src homology-3 domain,IPR001478:PDZ domain,IPR005417:Zona occludens protein,IPR005418:Zona occludens protein ZO-1,IPR008144:Guanylate kinase,IPR008145:Guanylate kinase/L-type calcium channel,IPR011511:Variant SH3,IPR027417:P-loop containing nucleoside triphosphate hydrolase, cfa04520:Adherens junction,cfa04530:Tight junction,cfa04540:Gap junction,cfa05132:Salmonella infection, SM00072:GuKc,SM00218:ZU5,SM00228:PDZ, Calmodulin-binding,Cell junction,Cell membrane,Complete proteome,Gap junction,Membrane,Phosphoprotein,Reference proteome,Repeat,SH3 domain,Tight junction, chain:Tight junction protein ZO-1,domain:Guanylate kinase-like,domain:PDZ 1,domain:PDZ 2,domain:PDZ 3,domain:SH3,domain:ZU5,modified residue, Q9UNS1 timeless circadian clock(TIMELESS) Homo sapiens GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0002009~morphogenesis of an epithelium,GO:0006260~DNA replication,GO:0006351~transcription, DNA-templated,GO:0006974~cellular response to DNA damage stimulus,GO:0007067~mitotic nuclear division,GO:0007623~circadian rhythm,GO:0009582~detection of abiotic stimulus,GO:0009628~response to abiotic stimulus,GO:0030324~lung development,GO:0042127~regulation of cell proliferation,GO:0042752~regulation of circadian rhythm,GO:0044770~cell cycle phase transition,GO:0045892~negative regulation of transcription, DNA-templated,GO:0048754~branching morphogenesis of an epithelial tube,GO:0051301~cell division,GO:0072711~cellular response to hydroxyurea,GO:0072719~cellular response to cisplatin,GO:1904976~cellular response to bleomycin,GO:2000781~positive regulation of double-strand break repair, GO:0000790~nuclear chromatin,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005730~nucleolus,GO:0015630~microtubule cytoskeleton, GO:0005515~protein binding,GO:0042803~protein homodimerization activity,GO:0046982~protein heterodimerization activity, IPR006906:Timeless protein,IPR007725:Timeless C-terminal, 3D-structure,Alternative splicing,Biological rhythms,Cell cycle,Cell division,Complete proteome,Developmental protein,DNA damage,Mitosis,Nucleus,Phosphoprotein,Polymorphism,Reference proteome,Transcription,Transcription regulation, chain:Protein timeless homolog,compositionally biased region:Glu-rich,modified residue,sequence variant,splice variant, Q8WZ42 titin(TTN) Homo sapiens GO:0002576~platelet degranulation,GO:0003300~cardiac muscle hypertrophy,GO:0006936~muscle contraction,GO:0006941~striated muscle contraction,GO:0007076~mitotic chromosome condensation,GO:0018108~peptidyl-tyrosine phosphorylation,GO:0030049~muscle filament sliding,GO:0030240~skeletal muscle thin filament assembly,GO:0030241~skeletal muscle myosin thick filament assembly,GO:0035995~detection of muscle stretch,GO:0045214~sarcomere organization,GO:0045859~regulation of protein kinase activity,GO:0048739~cardiac muscle fiber development,GO:0048769~sarcomerogenesis,GO:0050790~regulation of catalytic activity,GO:0051592~response to calcium ion,GO:0055003~cardiac myofibril assembly,GO:0055008~cardiac muscle tissue morphogenesis,GO:0060048~cardiac muscle contraction, GO:0000794~condensed nuclear chromosome,GO:0005576~extracellular region,GO:0005829~cytosol,GO:0005859~muscle myosin complex,GO:0005865~striated muscle thin filament,GO:0030018~Z disc,GO:0031430~M band,GO:0031674~I band,GO:0070062~extracellular exosome, GO:0002020~protease binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0004713~protein tyrosine kinase activity,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0005524~ATP binding,GO:0008307~structural constituent of muscle,GO:0019899~enzyme binding,GO:0019901~protein kinase binding,GO:0031433~telethonin binding,GO:0042802~identical protein binding,GO:0042805~actinin binding,GO:0043621~protein self-association,GO:0051015~actin filament binding,GO:0051371~muscle alpha-actinin binding,GO:0097493~structural molecule activity conferring elasticity, IPR000719:Protein kinase, catalytic domain,IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR003961:Fibronectin, type III,IPR004168:PPAK motif,IPR007110:Immunoglobulin-like domain,IPR008266:Tyrosine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR013098:Immunoglobulin I-set,IPR013106:Immunoglobulin V-set,IPR013783:Immunoglobulin-like fold,IPR015129:Titin Z, hsa05410:Hypertrophic cardiomyopathy (HCM),hsa05414:Dilated cardiomyopathy, 600334~Tibial muscular dystrophy, tardive,603689~Myopathy, proximal, with early respiratory muscle involvement,604145~Cardiomyopathy, dilated, 1G,608807~Muscular dystrophy, limb-girdle, type 2J,611705~Myopathy, early-onset, with fatal cardiomyopathy,613765~Cardiomyopathy, familial hypertrophic, 9, SM00060:FN3,SM00406:IGv,SM00408:IGc2,SM00409:IG, 3D-structure,Alternative splicing,ATP-binding,Calcium,Calmodulin-binding,Cardiomyopathy,Coiled coil,Complete proteome,Cytoplasm,Direct protein sequencing,Disease mutation,Disulfide bond,Immunoglobulin domain,Isopeptide bond,Kinase,Limb-girdle muscular dystrophy,Magnesium,Metal-binding,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Serine/threonine-protein kinase,Transferase, active site:Proton acceptor,binding site:ATP,chain:Titin,compositionally biased region:Ala-rich,compositionally biased region:Glu-rich,compositionally biased region:Poly-Arg,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Pro,compositionally biased region:Poly-Ser,compositionally biased region:Poly-Thr,compositionally biased region:Pro-rich,compositionally biased region:Ser-rich,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),disulfide bond,domain:Fibronectin type-III 1,domain:Fibronectin type-III 10,domain:Fibronectin type-III 100,domain:Fibronectin type-III 101,domain:Fibronectin type-III 102,domain:Fibronectin type-III 103,domain:Fibronectin type-III 104,domain:Fibronectin type-III 105,domain:Fibronectin type-III 106,domain:Fibronectin type-III 107,domain:Fibronectin type-III 108,domain:Fibronectin type-III 109,domain:Fibronectin type-III 11,domain:Fibronectin type-III 110,domain:Fibronectin type-III 111,domain:Fibronectin type-III 112,domain:Fibronectin type-III 113,domain:Fibronectin type-III 114,domain:Fibronectin type-III 115,domain:Fibronectin type-III 116,domain:Fibronectin type-III 117,domain:Fibronectin type-III 118,domain:Fibronectin type-III 119,domain:Fibronectin type-III 12,domain:Fibronectin type-III 120,domain:Fibronectin type-III 121,domain:Fibronectin type-III 122,domain:Fibronectin type-III 123,domain:Fibronectin type-III 124,domain:Fibronectin type-III 125,domain:Fibronectin type-III 126,domain:Fibronectin type-III 127,domain:Fibronectin type-III 128,domain:Fibronectin type-III 129,domain:Fibronectin type-III 13,domain:Fibronectin type-III 130,domain:Fibronectin type-III 131,domain:Fibronectin type-III 132,domain:Fibronectin type-III 14,domain:Fibronectin type-III 15,domain:Fibronectin type-III 16,domain:Fibronectin type-III 17,domain:Fibronectin type-III 18,domain:Fibronectin type-III 19,domain:Fibronectin type-III 2,domain:Fibronectin type-III 20,domain:Fibronectin type-III 21,domain:Fibronectin type-III 22,domain:Fibronectin type-III 23,domain:Fibronectin type-III 24,domain:Fibronectin type-III 25,domain:Fibronectin type-III 26,domain:Fibronectin type-III 27,domain:Fibronectin type-III 28,domain:Fibronectin type-III 29,domain:Fibronectin type-III 3,domain:Fibronectin type-III 30,domain:Fibronectin type-III 31,domain:Fibronectin type-III 32,domain:Fibronectin type-III 33,domain:Fibronectin type-III 34,domain:Fibronectin type-III 35,domain:Fibronectin type-III 36,domain:Fibronectin type-III 37,domain:Fibronectin type-III 38,domain:Fibronectin type-III 39,domain:Fibronectin type-III 4,domain:Fibronectin type-III 40,domain:Fibronectin type-III 41,domain:Fibronectin type-III 42,domain:Fibronectin type-III 43,domain:Fibronectin type-III 44,domain:Fibronectin type-III 45,domain:Fibronectin type-III 46,domain:Fibronectin type-III 47,domain:Fibronectin type-III 48,domain:Fibronectin type-III 49,domain:Fibronectin type-III 5,domain:Fibronectin type-III 50,domain:Fibronectin type-III 51,domain:Fibronectin type-III 52,domain:Fibronectin type-III 53,domain:Fibronectin type-III 54,domain:Fibronectin type-III 55,domain:Fibronectin type-III 56,domain:Fibronectin type-III 57,domain:Fibronectin type-III 58,domain:Fibronectin type-III 59,domain:Fibronectin type-III 6,domain:Fibronectin type-III 60,domain:Fibronectin type-III 61,domain:Fibronectin type-III 62,domain:Fibronectin type-III 63,domain:Fibronectin type-III 64,domain:Fibronectin type-III 65,domain:Fibronectin type-III 66,domain:Fibronectin type-III 67,domain:Fibronectin type-III 68,domain:Fibronectin type-III 69,domain:Fibronectin type-III 7,domain:Fibronectin type-III 70,domain:Fibronectin type-III 71,domain:Fibronectin type-III 72,domain:Fibronectin type-III 73,domain:Fibronectin type-III 74,domain:Fibronectin type-III 75,domain:Fibronectin type-III 76,domain:Fibronectin type-III 77,domain:Fibronectin type-III 78,domain:Fibronectin type-III 79,domain:Fibronectin type-III 8,domain:Fibronectin type-III 80,domain:Fibronectin type-III 81,domain:Fibronectin type-III 82,domain:Fibronectin type-III 83,domain:Fibronectin type-III 84,domain:Fibronectin type-III 85,domain:Fibronectin type-III 86,domain:Fibronectin type-III 87,domain:Fibronectin type-III 88,domain:Fibronectin type-III 89,domain:Fibronectin type-III 9,domain:Fibronectin type-III 90,domain:Fibronectin type-III 91,domain:Fibronectin type-III 92,domain:Fibronectin type-III 93,domain:Fibronectin type-III 94,domain:Fibronectin type-III 95,domain:Fibronectin type-III 96,domain:Fibronectin type-III 97,domain:Fibronectin type-III 98,domain:Fibronectin type-III 99,domain:Ig-like 1,domain:Ig-like 10,domain:Ig-like 100,domain:Ig-like 101,domain:Ig-like 102,domain:Ig-like 103,domain:Ig-like 104,domain:Ig-like 105,domain:Ig-like 106,domain:Ig-like 107,domain:Ig-like 108,domain:Ig-like 109,domain:Ig-like 11,domain:Ig-like 110,domain:Ig-like 111,domain:Ig-like 112,domain:Ig-like 113,domain:Ig-like 114,domain:Ig-like 115,domain:Ig-like 116,domain:Ig-like 117,domain:Ig-like 118,domain:Ig-like 119,domain:Ig-like 12,domain:Ig-like 120,domain:Ig-like 121,domain:Ig-like 122,domain:Ig-like 123,domain:Ig-like 124,domain:Ig-like 125,domain:Ig-like 126,domain:Ig-like 127,domain:Ig-like 128,domain:Ig-like 129,domain:Ig-like 13,domain:Ig-like 130,domain:Ig-like 131,domain:Ig-like 132,domain:Ig-like 133,domain:Ig-like 134,domain:Ig-like 135,domain:Ig-like 136,domain:Ig-like 137,domain:Ig-like 138,domain:Ig-like 139,domain:Ig-like 14,domain:Ig-like 140,domain:Ig-like 141,domain:Ig-like 142,domain:Ig-like 143,domain:Ig-like 144,domain:Ig-like 145,domain:Ig-like 146,domain:Ig-like 147,domain:Ig-like 148,domain:Ig-like 149,domain:Ig-like 15,domain:Ig-like 150,domain:Ig-like 151,domain:Ig-like 152,domain:Ig-like 16,domain:Ig-like 17,domain:Ig-like 18,domain:Ig-like 19,domain:Ig-like 2,domain:Ig-like 20,domain:Ig-like 21,domain:Ig-like 22,domain:Ig-like 23,domain:Ig-like 24,domain:Ig-like 25,domain:Ig-like 26,domain:Ig-like 27,domain:Ig-like 28,domain:Ig-like 29,domain:Ig-like 3,domain:Ig-like 30,domain:Ig-like 31,domain:Ig-like 32,domain:Ig-like 33,domain:Ig-like 34,domain:Ig-like 35,domain:Ig-like 36,domain:Ig-like 37,domain:Ig-like 38,domain:Ig-like 39,domain:Ig-like 4,domain:Ig-like 40,domain:Ig-like 41,domain:Ig-like 42,domain:Ig-like 43,domain:Ig-like 44,domain:Ig-like 45,domain:Ig-like 46,domain:Ig-like 47,domain:Ig-like 48,domain:Ig-like 49,domain:Ig-like 5,domain:Ig-like 50,domain:Ig-like 51,domain:Ig-like 52,domain:Ig-like 53,domain:Ig-like 54,domain:Ig-like 55,domain:Ig-like 56,domain:Ig-like 57,domain:Ig-like 58,domain:Ig-like 59,domain:Ig-like 6,domain:Ig-like 60,domain:Ig-like 61,domain:Ig-like 62,domain:Ig-like 63,domain:Ig-like 64,domain:Ig-like 65,domain:Ig-like 66,domain:Ig-like 67,domain:Ig-like 68,domain:Ig-like 69,domain:Ig-like 7,domain:Ig-like 70,domain:Ig-like 71,domain:Ig-like 72,domain:Ig-like 73,domain:Ig-like 74,domain:Ig-like 75,domain:Ig-like 76,domain:Ig-like 77,domain:Ig-like 78,domain:Ig-like 79,domain:Ig-like 8,domain:Ig-like 80,domain:Ig-like 81,domain:Ig-like 82,domain:Ig-like 83,domain:Ig-like 84,domain:Ig-like 85,domain:Ig-like 86,domain:Ig-like 87,domain:Ig-like 88,domain:Ig-like 89,domain:Ig-like 9,domain:Ig-like 90,domain:Ig-like 91,domain:Ig-like 92,domain:Ig-like 93,domain:Ig-like 94,domain:Ig-like 95,domain:Ig-like 96,domain:Ig-like 97,domain:Ig-like 98,domain:Ig-like 99,domain:Protein kinase,helix,modified residue,mutagenesis site,nucleotide phosphate-binding region:ATP,region of interest:ZIS1,region of interest:ZIS5,repeat:Kelch 1,repeat:Kelch 10,repeat:Kelch 11,repeat:Kelch 12,repeat:Kelch 13,repeat:Kelch 14,repeat:Kelch 15,repeat:Kelch 16,repeat:Kelch 17,repeat:Kelch 18,repeat:Kelch 19,repeat:Kelch 2,repeat:Kelch 3,repeat:Kelch 4,repeat:Kelch 5,repeat:Kelch 6,repeat:Kelch 7,repeat:Kelch 8,repeat:Kelch 9,repeat:PEVK 1,repeat:PEVK 10,repeat:PEVK 11,repeat:PEVK 12,repeat:PEVK 13,repeat:PEVK 14,repeat:PEVK 15,repeat:PEVK 16,repeat:PEVK 17,repeat:PEVK 18,repeat:PEVK 19,repeat:PEVK 2,repeat:PEVK 20,repeat:PEVK 21,repeat:PEVK 22,repeat:PEVK 23,repeat:PEVK 24,repeat:PEVK 25,repeat:PEVK 26,repeat:PEVK 27,repeat:PEVK 28,repeat:PEVK 29,repeat:PEVK 3,repeat:PEVK 30,repeat:PEVK 31,repeat:PEVK 4,repeat:PEVK 5,repeat:PEVK 6,repeat:PEVK 7,repeat:PEVK 8,repeat:PEVK 9,repeat:RCC1 1,repeat:RCC1 10,repeat:RCC1 11,repeat:RCC1 12,repeat:RCC1 13,repeat:RCC1 14,repeat:RCC1 15,repeat:RCC1 16,repeat:RCC1 17,repeat:RCC1 2,repeat:RCC1 3,repeat:RCC1 4,repeat:RCC1 5,repeat:RCC1 6,repeat:RCC1 7,repeat:RCC1 8,repeat:RCC1 9,repeat:TPR 1,repeat:TPR 10,repeat:TPR 11,repeat:TPR 12,repeat:TPR 13,repeat:TPR 14,repeat:TPR 2,repeat:TPR 3,repeat:TPR 4,repeat:TPR 5,repeat:TPR 6,repeat:TPR 7,repeat:TPR 8,repeat:TPR 9,repeat:WD 1,repeat:WD 10,repeat:WD 11,repeat:WD 12,repeat:WD 13,repeat:WD 14,repeat:WD 15,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,repeat:WD 8,repeat:WD 9,repeat:Z-repeat 1,repeat:Z-repeat 2,repeat:Z-repeat 3,repeat:Z-repeat 4,repeat:Z-repeat 5,repeat:Z-repeat 6,repeat:Z-repeat 7,sequence conflict,sequence variant,splice variant,strand,turn, A2ASS6 titin(Ttn) Mus musculus GO:0001701~in utero embryonic development,GO:0001756~somitogenesis,GO:0003007~heart morphogenesis,GO:0003300~cardiac muscle hypertrophy,GO:0006936~muscle contraction,GO:0006941~striated muscle contraction,GO:0007507~heart development,GO:0007512~adult heart development,GO:0021591~ventricular system development,GO:0030240~skeletal muscle thin filament assembly,GO:0030241~skeletal muscle myosin thick filament assembly,GO:0035995~detection of muscle stretch,GO:0043056~forward locomotion,GO:0045214~sarcomere organization,GO:0045859~regulation of protein kinase activity,GO:0048739~cardiac muscle fiber development,GO:0048769~sarcomerogenesis,GO:0050790~regulation of catalytic activity,GO:0051592~response to calcium ion,GO:0055002~striated muscle cell development,GO:0055003~cardiac myofibril assembly,GO:0055008~cardiac muscle tissue morphogenesis,GO:0060048~cardiac muscle contraction,GO:0060419~heart growth,GO:1901897~regulation of relaxation of cardiac muscle, GO:0000794~condensed nuclear chromosome,GO:0005859~muscle myosin complex,GO:0005865~striated muscle thin filament,GO:0030016~myofibril,GO:0030017~sarcomere,GO:0030018~Z disc,GO:0031430~M band,GO:0031672~A band,GO:0031674~I band,GO:0070062~extracellular exosome, GO:0002020~protease binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0004713~protein tyrosine kinase activity,GO:0005200~structural constituent of cytoskeleton,GO:0005509~calcium ion binding,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0005524~ATP binding,GO:0008307~structural constituent of muscle,GO:0019899~enzyme binding,GO:0019901~protein kinase binding,GO:0030506~ankyrin binding,GO:0031433~telethonin binding,GO:0042802~identical protein binding,GO:0042805~actinin binding,GO:0043621~protein self-association,GO:0051015~actin filament binding,GO:0051371~muscle alpha-actinin binding,GO:0097493~structural molecule activity conferring elasticity, IPR000477:Reverse transcriptase,IPR000719:Protein kinase, catalytic domain,IPR003598:Immunoglobulin subtype 2,IPR003599:Immunoglobulin subtype,IPR003961:Fibronectin, type III,IPR004168:PPAK motif,IPR007110:Immunoglobulin-like domain,IPR008266:Tyrosine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR013098:Immunoglobulin I-set,IPR013106:Immunoglobulin V-set,IPR013783:Immunoglobulin-like fold,IPR015129:Titin Z, mmu05410:Hypertrophic cardiomyopathy (HCM),mmu05414:Dilated cardiomyopathy, SM00060:FN3,SM00406:IGv,SM00408:IGc2,SM00409:IG, Alternative splicing,ATP-binding,Calcium,Calmodulin-binding,Coiled coil,Complete proteome,Cytoplasm,Direct protein sequencing,Disulfide bond,Immunoglobulin domain,Isopeptide bond,Kelch repeat,Kinase,Magnesium,Metal-binding,Methylation,Nucleotide-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Serine/threonine-protein kinase,TPR repeat,Transferase,WD repeat, active site:Proton acceptor,binding site:ATP,chain:Titin,compositionally biased region:Glu-rich,compositionally biased region:Poly-Ala,compositionally biased region:Poly-Arg,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Ser,compositionally biased region:Poly-Thr,compositionally biased region:Pro-rich,compositionally biased region:Ser-rich,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),disulfide bond,domain:Fibronectin type-III 1,domain:Fibronectin type-III 10,domain:Fibronectin type-III 100,domain:Fibronectin type-III 101,domain:Fibronectin type-III 102,domain:Fibronectin type-III 103,domain:Fibronectin type-III 104,domain:Fibronectin type-III 105,domain:Fibronectin type-III 106,domain:Fibronectin type-III 107,domain:Fibronectin type-III 108,domain:Fibronectin type-III 109,domain:Fibronectin type-III 11,domain:Fibronectin type-III 110,domain:Fibronectin type-III 111,domain:Fibronectin type-III 112,domain:Fibronectin type-III 113,domain:Fibronectin type-III 114,domain:Fibronectin type-III 115,domain:Fibronectin type-III 116,domain:Fibronectin type-III 117,domain:Fibronectin type-III 118,domain:Fibronectin type-III 119,domain:Fibronectin type-III 12,domain:Fibronectin type-III 120,domain:Fibronectin type-III 121,domain:Fibronectin type-III 122,domain:Fibronectin type-III 123,domain:Fibronectin type-III 124,domain:Fibronectin type-III 125,domain:Fibronectin type-III 126,domain:Fibronectin type-III 127,domain:Fibronectin type-III 128,domain:Fibronectin type-III 129,domain:Fibronectin type-III 13,domain:Fibronectin type-III 130,domain:Fibronectin type-III 131,domain:Fibronectin type-III 132,domain:Fibronectin type-III 133,domain:Fibronectin type-III 134,domain:Fibronectin type-III 14,domain:Fibronectin type-III 15,domain:Fibronectin type-III 16,domain:Fibronectin type-III 17,domain:Fibronectin type-III 18,domain:Fibronectin type-III 19,domain:Fibronectin type-III 2,domain:Fibronectin type-III 20,domain:Fibronectin type-III 21,domain:Fibronectin type-III 22,domain:Fibronectin type-III 23,domain:Fibronectin type-III 24,domain:Fibronectin type-III 25,domain:Fibronectin type-III 26,domain:Fibronectin type-III 27,domain:Fibronectin type-III 28,domain:Fibronectin type-III 29,domain:Fibronectin type-III 3,domain:Fibronectin type-III 30,domain:Fibronectin type-III 31,domain:Fibronectin type-III 32,domain:Fibronectin type-III 33,domain:Fibronectin type-III 34,domain:Fibronectin type-III 35,domain:Fibronectin type-III 36,domain:Fibronectin type-III 37,domain:Fibronectin type-III 38,domain:Fibronectin type-III 39,domain:Fibronectin type-III 4,domain:Fibronectin type-III 40,domain:Fibronectin type-III 41,domain:Fibronectin type-III 42,domain:Fibronectin type-III 43,domain:Fibronectin type-III 44,domain:Fibronectin type-III 45,domain:Fibronectin type-III 46,domain:Fibronectin type-III 47,domain:Fibronectin type-III 48,domain:Fibronectin type-III 49,domain:Fibronectin type-III 5,domain:Fibronectin type-III 50,domain:Fibronectin type-III 51,domain:Fibronectin type-III 52,domain:Fibronectin type-III 53,domain:Fibronectin type-III 54,domain:Fibronectin type-III 55,domain:Fibronectin type-III 56,domain:Fibronectin type-III 57,domain:Fibronectin type-III 58,domain:Fibronectin type-III 59,domain:Fibronectin type-III 6,domain:Fibronectin type-III 60,domain:Fibronectin type-III 61,domain:Fibronectin type-III 62,domain:Fibronectin type-III 63,domain:Fibronectin type-III 64,domain:Fibronectin type-III 65,domain:Fibronectin type-III 66,domain:Fibronectin type-III 67,domain:Fibronectin type-III 68,domain:Fibronectin type-III 69,domain:Fibronectin type-III 7,domain:Fibronectin type-III 70,domain:Fibronectin type-III 71,domain:Fibronectin type-III 72,domain:Fibronectin type-III 73,domain:Fibronectin type-III 74,domain:Fibronectin type-III 75,domain:Fibronectin type-III 76,domain:Fibronectin type-III 77,domain:Fibronectin type-III 78,domain:Fibronectin type-III 79,domain:Fibronectin type-III 8,domain:Fibronectin type-III 80,domain:Fibronectin type-III 81,domain:Fibronectin type-III 82,domain:Fibronectin type-III 83,domain:Fibronectin type-III 84,domain:Fibronectin type-III 85,domain:Fibronectin type-III 86,domain:Fibronectin type-III 87,domain:Fibronectin type-III 88,domain:Fibronectin type-III 89,domain:Fibronectin type-III 9,domain:Fibronectin type-III 90,domain:Fibronectin type-III 91,domain:Fibronectin type-III 92,domain:Fibronectin type-III 93,domain:Fibronectin type-III 94,domain:Fibronectin type-III 95,domain:Fibronectin type-III 96,domain:Fibronectin type-III 97,domain:Fibronectin type-III 98,domain:Fibronectin type-III 99,domain:Ig-like 1,domain:Ig-like 10,domain:Ig-like 100,domain:Ig-like 101,domain:Ig-like 102,domain:Ig-like 103,domain:Ig-like 104,domain:Ig-like 105,domain:Ig-like 106,domain:Ig-like 107,domain:Ig-like 108,domain:Ig-like 109,domain:Ig-like 11,domain:Ig-like 110,domain:Ig-like 111,domain:Ig-like 112,domain:Ig-like 113,domain:Ig-like 114,domain:Ig-like 115,domain:Ig-like 116,domain:Ig-like 117,domain:Ig-like 118,domain:Ig-like 119,domain:Ig-like 12,domain:Ig-like 120,domain:Ig-like 121,domain:Ig-like 122,domain:Ig-like 123,domain:Ig-like 124,domain:Ig-like 125,domain:Ig-like 126,domain:Ig-like 127,domain:Ig-like 128,domain:Ig-like 129,domain:Ig-like 13,domain:Ig-like 130,domain:Ig-like 131,domain:Ig-like 132,domain:Ig-like 133,domain:Ig-like 134,domain:Ig-like 135,domain:Ig-like 136,domain:Ig-like 137,domain:Ig-like 138,domain:Ig-like 139,domain:Ig-like 14,domain:Ig-like 140,domain:Ig-like 141,domain:Ig-like 142,domain:Ig-like 143,domain:Ig-like 144,domain:Ig-like 15,domain:Ig-like 16,domain:Ig-like 17,domain:Ig-like 18,domain:Ig-like 19,domain:Ig-like 2,domain:Ig-like 20,domain:Ig-like 21,domain:Ig-like 22,domain:Ig-like 23,domain:Ig-like 24,domain:Ig-like 25,domain:Ig-like 26,domain:Ig-like 27,domain:Ig-like 28,domain:Ig-like 29,domain:Ig-like 3,domain:Ig-like 30,domain:Ig-like 31,domain:Ig-like 32,domain:Ig-like 33,domain:Ig-like 34,domain:Ig-like 35,domain:Ig-like 36,domain:Ig-like 37,domain:Ig-like 38,domain:Ig-like 39,domain:Ig-like 4,domain:Ig-like 40,domain:Ig-like 41,domain:Ig-like 42,domain:Ig-like 43,domain:Ig-like 44,domain:Ig-like 45,domain:Ig-like 46,domain:Ig-like 47,domain:Ig-like 48,domain:Ig-like 49,domain:Ig-like 5,domain:Ig-like 50,domain:Ig-like 51,domain:Ig-like 52,domain:Ig-like 53,domain:Ig-like 54,domain:Ig-like 55,domain:Ig-like 56,domain:Ig-like 57,domain:Ig-like 58,domain:Ig-like 59,domain:Ig-like 6,domain:Ig-like 60,domain:Ig-like 61,domain:Ig-like 62,domain:Ig-like 63,domain:Ig-like 64,domain:Ig-like 65,domain:Ig-like 66,domain:Ig-like 67,domain:Ig-like 68,domain:Ig-like 69,domain:Ig-like 7,domain:Ig-like 70,domain:Ig-like 71,domain:Ig-like 72,domain:Ig-like 73,domain:Ig-like 74,domain:Ig-like 75,domain:Ig-like 76,domain:Ig-like 77,domain:Ig-like 78,domain:Ig-like 79,domain:Ig-like 8,domain:Ig-like 80,domain:Ig-like 81,domain:Ig-like 82,domain:Ig-like 83,domain:Ig-like 84,domain:Ig-like 85,domain:Ig-like 86,domain:Ig-like 87,domain:Ig-like 88,domain:Ig-like 89,domain:Ig-like 9,domain:Ig-like 90,domain:Ig-like 91,domain:Ig-like 92,domain:Ig-like 93,domain:Ig-like 94,domain:Ig-like 95,domain:Ig-like 96,domain:Ig-like 97,domain:Ig-like 98,domain:Ig-like 99,domain:Protein kinase,modified residue,nucleotide phosphate-binding region:ATP,region of interest:ZIS1,region of interest:ZIS5,repeat:Kelch 1,repeat:Kelch 10,repeat:Kelch 11,repeat:Kelch 12,repeat:Kelch 13,repeat:Kelch 14,repeat:Kelch 15,repeat:Kelch 16,repeat:Kelch 17,repeat:Kelch 18,repeat:Kelch 2,repeat:Kelch 3,repeat:Kelch 4,repeat:Kelch 5,repeat:Kelch 6,repeat:Kelch 7,repeat:Kelch 8,repeat:Kelch 9,repeat:PEVK 1,repeat:PEVK 10,repeat:PEVK 11,repeat:PEVK 12,repeat:PEVK 13,repeat:PEVK 14,repeat:PEVK 15,repeat:PEVK 16,repeat:PEVK 17,repeat:PEVK 18,repeat:PEVK 19,repeat:PEVK 2,repeat:PEVK 20,repeat:PEVK 21,repeat:PEVK 22,repeat:PEVK 23,repeat:PEVK 24,repeat:PEVK 25,repeat:PEVK 26,repeat:PEVK 27,repeat:PEVK 28,repeat:PEVK 29,repeat:PEVK 3,repeat:PEVK 30,repeat:PEVK 31,repeat:PEVK 32,repeat:PEVK 33,repeat:PEVK 34,repeat:PEVK 35,repeat:PEVK 36,repeat:PEVK 37,repeat:PEVK 38,repeat:PEVK 39,repeat:PEVK 4,repeat:PEVK 40,repeat:PEVK 41,repeat:PEVK 42,repeat:PEVK 43,repeat:PEVK 44,repeat:PEVK 45,repeat:PEVK 46,repeat:PEVK 47,repeat:PEVK 48,repeat:PEVK 49,repeat:PEVK 5,repeat:PEVK 50,repeat:PEVK 51,repeat:PEVK 52,repeat:PEVK 53,repeat:PEVK 54,repeat:PEVK 55,repeat:PEVK 56,repeat:PEVK 57,repeat:PEVK 58,repeat:PEVK 59,repeat:PEVK 6,repeat:PEVK 60,repeat:PEVK 61,repeat:PEVK 62,repeat:PEVK 63,repeat:PEVK 64,repeat:PEVK 65,repeat:PEVK 66,repeat:PEVK 67,repeat:PEVK 68,repeat:PEVK 69,repeat:PEVK 7,repeat:PEVK 70,repeat:PEVK 71,repeat:PEVK 72,repeat:PEVK 73,repeat:PEVK 74,repeat:PEVK 75,repeat:PEVK 76,repeat:PEVK 8,repeat:PEVK 9,repeat:RCC1 1,repeat:RCC1 10,repeat:RCC1 11,repeat:RCC1 12,repeat:RCC1 2,repeat:RCC1 3,repeat:RCC1 4,repeat:RCC1 5,repeat:RCC1 6,repeat:RCC1 7,repeat:RCC1 8,repeat:RCC1 9,repeat:TPR 1,repeat:TPR 10,repeat:TPR 11,repeat:TPR 12,repeat:TPR 13,repeat:TPR 14,repeat:TPR 15,repeat:TPR 2,repeat:TPR 3,repeat:TPR 4,repeat:TPR 5,repeat:TPR 6,repeat:TPR 7,repeat:TPR 8,repeat:TPR 9,repeat:WD 1,repeat:WD 10,repeat:WD 11,repeat:WD 12,repeat:WD 13,repeat:WD 14,repeat:WD 15,repeat:WD 16,repeat:WD 17,repeat:WD 2,repeat:WD 3,repeat:WD 4,repeat:WD 5,repeat:WD 6,repeat:WD 7,repeat:WD 8,repeat:WD 9,repeat:Z-repeat 1,repeat:Z-repeat 2,repeat:Z-repeat 3,repeat:Z-repeat 4,repeat:Z-repeat 5,repeat:Z-repeat 6,splice variant, Q800K6 topoisomerase (DNA) II binding protein 1 L homeolog(topbp1.L) Xenopus laevis GO:0000076~DNA replication checkpoint,GO:0006260~DNA replication,GO:0006270~DNA replication initiation,GO:0006281~DNA repair,GO:0006974~cellular response to DNA damage stimulus,GO:0007049~cell cycle,GO:0030174~regulation of DNA-dependent DNA replication initiation,GO:0033138~positive regulation of peptidyl-serine phosphorylation,GO:0035563~positive regulation of chromatin binding,GO:0045860~positive regulation of protein kinase activity,GO:0071163~DNA replication preinitiation complex assembly,GO:0071165~GINS complex assembly,GO:0071168~protein localization to chromatin, GO:0000785~chromatin,GO:0000922~spindle pole,GO:0005634~nucleus,GO:0005694~chromosome,GO:0005737~cytoplasm,GO:0005815~microtubule organizing center, GO:0003677~DNA binding,GO:0003682~chromatin binding,GO:0019900~kinase binding, IPR001357:BRCT domain,IPR016126:Secretoglobin,IPR026993:DNA topoisomerase 2-binding protein 1, SM00292:BRCT, Cell cycle,Chromosome,Cytoplasm,Cytoskeleton,DNA damage,DNA repair,DNA replication,DNA-binding,Nucleus,Phosphoprotein,Repeat, Q80Z37 topoisomerase I binding, arginine/serine-rich(Topors) Mus musculus GO:0000209~protein polyubiquitination,GO:0006511~ubiquitin-dependent protein catabolic process,GO:0006513~protein monoubiquitination,GO:0006974~cellular response to DNA damage stimulus,GO:0008630~intrinsic apoptotic signaling pathway in response to DNA damage,GO:0016925~protein sumoylation,GO:0034504~protein localization to nucleus,GO:0042127~regulation of cell proliferation,GO:0042771~intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator,GO:0043161~proteasome-mediated ubiquitin-dependent protein catabolic process,GO:0045893~positive regulation of transcription, DNA-templated,GO:0051443~positive regulation of ubiquitin-protein transferase activity,GO:0051457~maintenance of protein location in nucleus,GO:0070936~protein K48-linked ubiquitination, GO:0000151~ubiquitin ligase complex,GO:0000922~spindle pole,GO:0000930~gamma-tubulin complex,GO:0005634~nucleus,GO:0005814~centriole,GO:0016605~PML body,GO:0016607~nuclear speck,GO:0032391~photoreceptor connecting cilium,GO:0036064~ciliary basal body, GO:0003677~DNA binding,GO:0003823~antigen binding,GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0019789~SUMO transferase activity,GO:0044547~DNA topoisomerase binding,GO:0046872~metal ion binding,GO:0061630~ubiquitin protein ligase activity, IPR001841:Zinc finger, RING-type,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR017907:Zinc finger, RING-type, conserved site, SM00184:RING, Complete proteome,DNA damage,Isopeptide bond,Ligase,Metal-binding,Nucleus,Phosphoprotein,Reference proteome,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, chain:E3 ubiquitin-protein ligase Topors,compositionally biased region:Arg-rich,compositionally biased region:Lys-rich,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO),modified residue,region of interest:Interaction with p53,region of interest:Interaction with SUMO1,region of interest:Interaction with TOP1,region of interest:Interaction with UBE2I,region of interest:Required for DNA-binding,region of interest:Sumoylation and localization to discrete nuclear foci,sequence conflict,zinc finger region:RING-type, Q6PBY7 trafficking protein particle complex 13(trappc13) Danio rerio IPR010378:Protein of unknown function DUF974, Complete proteome,Proteomics identification,Reference proteome, chain:UPF0533 protein C5orf44 homolog, P37837 transaldolase 1(TALDO1) Homo sapiens GO:0005975~carbohydrate metabolic process,GO:0005999~xylulose biosynthetic process,GO:0006002~fructose 6-phosphate metabolic process,GO:0006098~pentose-phosphate shunt,GO:0009052~pentose-phosphate shunt, non-oxidative branch, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005829~cytosol,GO:0043231~intracellular membrane-bounded organelle,GO:0070062~extracellular exosome, GO:0003824~catalytic activity,GO:0004801~sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity,GO:0005515~protein binding,GO:0048029~monosaccharide binding, IPR001585:Transaldolase,IPR004730:Transaldolase type 1,IPR013785:Aldolase-type TIM barrel,IPR018225:Transaldolase, active site, hsa00030:Pentose phosphate pathway,hsa01100:Metabolic pathways,hsa01130:Biosynthesis of antibiotics,hsa01200:Carbon metabolism,hsa01230:Biosynthesis of amino acids, 606003~Transaldolase deficiency, 3D-structure,Acetylation,Complete proteome,Cytoplasm,Disease mutation,Pentose shunt,Phosphoprotein,Proteomics identification,Reference proteome,Schiff base,Transferase, chain:Transaldolase,helix,modified residue,sequence variant,strand,turn, Q9BQ70 transcription factor 25(TCF25) Homo sapiens GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0006351~transcription, DNA-templated,GO:0007507~heart development, GO:0005634~nucleus, GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0005515~protein binding, IPR006994:Transcription factor 25,IPR011990:Tetratricopeptide-like helical, Complete proteome,DNA-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repressor,Transcription,Transcription regulation, chain:Transcription factor 25,modified residue, Q80YV3 transformation/transcription domain-associated protein(Trrap) Mus musculus m_pitx2Pathway:Multi-step Regulation of Transcription by Pitx2, GO:0006281~DNA repair,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0007093~mitotic cell cycle checkpoint,GO:0016569~covalent chromatin modification,GO:0016573~histone acetylation,GO:0016578~histone deubiquitination,GO:0043967~histone H4 acetylation,GO:0043968~histone H2A acetylation, GO:0000123~histone acetyltransferase complex,GO:0000812~Swr1 complex,GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005667~transcription factor complex,GO:0005794~Golgi apparatus,GO:0030914~STAGA complex,GO:0033276~transcription factor TFTC complex,GO:0035267~NuA4 histone acetyltransferase complex, GO:0003682~chromatin binding,GO:0003712~transcription cofactor activity,GO:0003713~transcription coactivator activity,GO:0016301~kinase activity, IPR000403:Phosphatidylinositol 3-/4-kinase, catalytic domain,IPR003151:PIK-related kinase, FAT,IPR003152:PIK-related kinase, FATC,IPR011009:Protein kinase-like domain,IPR011989:Armadillo-like helical,IPR011990:Tetratricopeptide-like helical,IPR014009:PIK-related kinase,IPR016024:Armadillo-type fold, mmu05166:HTLV-I infection, SM00146:PI3Kc,SM01343:SM01343, Acetylation,Activator,Chromatin regulator,Coiled coil,Complete proteome,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation, chain:Transformation/transcription domain- associated protein,domain:FAT,domain:FATC,domain:PI3K/PI4K,modified residue,region of interest:Interaction with TP53,short sequence motif:Bipartite nuclear localization signal, O75410 transforming acidic coiled-coil containing protein 1(TACC1) Homo sapiens GO:0000226~microtubule cytoskeleton organization,GO:0007049~cell cycle,GO:0008283~cell proliferation,GO:0021987~cerebral cortex development,GO:0051301~cell division, GO:0005634~nucleus,GO:0005737~cytoplasm,GO:0005815~microtubule organizing center,GO:0015630~microtubule cytoskeleton,GO:0016020~membrane,GO:0030496~midbody,GO:0045111~intermediate filament cytoskeleton, GO:0005515~protein binding, IPR007707:Transforming acidic coiled-coil, Acetylation,Alternative splicing,Cell cycle,Cell division,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Lipoprotein,Membrane,Myristate,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat, chain:Transforming acidic coiled-coil- containing protein 1,domain:SPAZ 1,domain:SPAZ 2,modified residue,region of interest:Interaction with CH-TOG,region of interest:Interaction with LSM7 and SNRPG,region of interest:Interaction with TDRD7,region of interest:Interaction with YEATS4,sequence conflict,sequence variant,short sequence motif:Bipartite nuclear localization signal 1,short sequence motif:Bipartite nuclear localization signal 2,splice variant, O94759 transient receptor potential cation channel subfamily M member 2(TRPM2) Homo sapiens GO:0001659~temperature homeostasis,GO:0002407~dendritic cell chemotaxis,GO:0006816~calcium ion transport,GO:0006979~response to oxidative stress,GO:0014074~response to purine-containing compound,GO:0032024~positive regulation of insulin secretion,GO:0035584~calcium-mediated signaling using intracellular calcium source,GO:0035725~sodium ion transmembrane transport,GO:0044849~estrous cycle,GO:0051209~release of sequestered calcium ion into cytosol,GO:0051489~regulation of filopodium assembly,GO:0070301~cellular response to hydrogen peroxide,GO:0070588~calcium ion transmembrane transport,GO:0071277~cellular response to calcium ion,GO:0071415~cellular response to purine-containing compound,GO:0071502~cellular response to temperature stimulus,GO:0071577~zinc II ion transmembrane transport,GO:0097028~dendritic cell differentiation,GO:0097553~calcium ion transmembrane import into cytosol,GO:0098703~calcium ion import across plasma membrane,GO:1903223~positive regulation of oxidative stress-induced neuron death,GO:2000249~regulation of actin cytoskeleton reorganization, GO:0005764~lysosome,GO:0005765~lysosomal membrane,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane,GO:0030659~cytoplasmic vesicle membrane,GO:0043005~neuron projection,GO:0043025~neuronal cell body,GO:0043204~perikaryon, GO:0005261~cation channel activity,GO:0005262~calcium channel activity,GO:0005272~sodium channel activity,GO:0005509~calcium ion binding,GO:0015278~calcium-release channel activity,GO:0016787~hydrolase activity,GO:0047631~ADP-ribose diphosphatase activity,GO:0099604~ligand-gated calcium channel activity, IPR000086:NUDIX hydrolase domain,IPR005821:Ion transport domain,IPR015797:NUDIX hydrolase domain-like, hsa04921:Oxytocin signaling pathway, Alternative splicing,Calcium,Calcium channel,Calcium transport,Cell membrane,Cell projection,Complete proteome,Cytoplasmic vesicle,Ion channel,Ion transport,Lysosome,Membrane,Polymorphism,Proteomics identification,Receptor,Reference proteome,Sodium,Sodium channel,Sodium transport,Transmembrane,Transmembrane helix,Transport, chain:Transient receptor potential cation channel subfamily M member 2,domain:Nudix hydrolase,modified residue,mutagenesis site,nucleotide phosphate-binding region:NAD,sequence conflict,sequence variant,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q9H1D0 transient receptor potential cation channel subfamily V member 6(TRPV6) Homo sapiens GO:0006816~calcium ion transport,GO:0017158~regulation of calcium ion-dependent exocytosis,GO:0051592~response to calcium ion,GO:0055074~calcium ion homeostasis,GO:0070588~calcium ion transmembrane transport,GO:1990035~calcium ion import into cell, GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016021~integral component of membrane,GO:0070062~extracellular exosome, GO:0005262~calcium channel activity,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0046872~metal ion binding, IPR002110:Ankyrin repeat,IPR004729:Transient receptor potential channel,IPR005821:Ion transport domain,IPR008344:Transient receptor potential channel, vanilloid 5/6,IPR008345:Transient receptor potential channel, vanilloid 6,IPR020683:Ankyrin repeat-containing domain, hsa04970:Salivary secretion,hsa04978:Mineral absorption, SM00248:ANK, Alternative splicing,ANK repeat,Calcium,Calcium channel,Calcium transport,Calmodulin-binding,Cell membrane,Complete proteome,Glycoprotein,Ion channel,Ion transport,Membrane,Metal-binding,Phosphoprotein,Polymorphism,Receptor,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Transport, chain:Transient receptor potential cation channel subfamily V member 6,glycosylation site:N-linked (GlcNAc...),modified residue,mutagenesis site,region of interest:Interaction with calmodulin,region of interest:Interaction with S100A10,repeat:ANK 1,repeat:ANK 2,repeat:ANK 3,repeat:ANK 4,repeat:ANK 5,sequence conflict,sequence variant,short sequence motif:Selectivity filter,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,topological domain:Pore forming,transmembrane region, Q91YD4 transient receptor potential cation channel, subfamily M, member 2(Trpm2) Mus musculus GO:0001659~temperature homeostasis,GO:0002407~dendritic cell chemotaxis,GO:0006810~transport,GO:0006811~ion transport,GO:0006812~cation transport,GO:0006814~sodium ion transport,GO:0006816~calcium ion transport,GO:0006828~manganese ion transport,GO:0006979~response to oxidative stress,GO:0009408~response to heat,GO:0014074~response to purine-containing compound,GO:0032024~positive regulation of insulin secretion,GO:0033194~response to hydroperoxide,GO:0034220~ion transmembrane transport,GO:0035584~calcium-mediated signaling using intracellular calcium source,GO:0051209~release of sequestered calcium ion into cytosol,GO:0051489~regulation of filopodium assembly,GO:0055085~transmembrane transport,GO:0070301~cellular response to hydrogen peroxide,GO:0070588~calcium ion transmembrane transport,GO:0071277~cellular response to calcium ion,GO:0071415~cellular response to purine-containing compound,GO:0071502~cellular response to temperature stimulus,GO:0071577~zinc II ion transmembrane transport,GO:0097028~dendritic cell differentiation,GO:0097553~calcium ion transmembrane import into cytosol,GO:0098703~calcium ion import across plasma membrane,GO:1903223~positive regulation of oxidative stress-induced neuron death,GO:2000249~regulation of actin cytoskeleton reorganization, GO:0005764~lysosome,GO:0005765~lysosomal membrane,GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane,GO:0030659~cytoplasmic vesicle membrane,GO:0043005~neuron projection,GO:0043025~neuronal cell body, GO:0005216~ion channel activity,GO:0005261~cation channel activity,GO:0005262~calcium channel activity,GO:0005272~sodium channel activity,GO:0005384~manganese ion transmembrane transporter activity,GO:0005509~calcium ion binding,GO:0015278~calcium-release channel activity,GO:0016787~hydrolase activity,GO:0047631~ADP-ribose diphosphatase activity,GO:0099604~ligand-gated calcium channel activity, IPR000086:NUDIX hydrolase domain,IPR005821:Ion transport domain,IPR015797:NUDIX hydrolase domain-like, mmu04921:Oxytocin signaling pathway, Calcium,Calcium channel,Calcium transport,Cell membrane,Cell projection,Complete proteome,Cytoplasmic vesicle,Ion channel,Ion transport,Lysosome,Membrane,Reference proteome,Sodium,Sodium channel,Sodium transport,Transmembrane,Transmembrane helix,Transport, chain:Transient receptor potential cation channel subfamily M member 2,domain:Nudix hydrolase,modified residue,nucleotide phosphate-binding region:NAD,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q5FVF4 transmembrane 7 superfamily member 3(Tm7sf3) Rattus norvegicus GO:0005886~plasma membrane,GO:0016021~integral component of membrane,GO:0070062~extracellular exosome, IPR025256:Domain of unknown function DUF4203, Cell membrane,Complete proteome,Glycoprotein,Membrane,Reference proteome,Signal,Transmembrane,Transmembrane helix, chain:Transmembrane 7 superfamily member 3,compositionally biased region:Phe-rich,glycosylation site:N-linked (GlcNAc...),signal peptide,transmembrane region, Q99805 transmembrane 9 superfamily member 2(TM9SF2) Homo sapiens GO:0006810~transport, GO:0005768~endosome,GO:0005887~integral component of plasma membrane,GO:0010008~endosome membrane,GO:0016021~integral component of membrane,GO:0070062~extracellular exosome, IPR004240:Nonaspanin (TM9SF), Complete proteome,Endosome,Membrane,Reference proteome,Signal,Transmembrane,Transmembrane helix, chain:Transmembrane 9 superfamily member 2,signal peptide,topological domain:Cytoplasmic,topological domain:Lumenal,transmembrane region, Q7ZY86 transmembrane protein 168 S homeolog(tmem168.S) Xenopus laevis GO:0016021~integral component of membrane, Glycoprotein,Membrane,Transmembrane,Transmembrane helix, chain:Transmembrane protein 168,glycosylation site:N-linked (GlcNAc...),transmembrane region, Q86WV6 transmembrane protein 173(TMEM173) Homo sapiens GO:0002218~activation of innate immune response,GO:0002230~positive regulation of defense response to virus by host,GO:0006915~apoptotic process,GO:0032092~positive regulation of protein binding,GO:0032479~regulation of type I interferon production,GO:0032481~positive regulation of type I interferon production,GO:0032608~interferon-beta production,GO:0033160~positive regulation of protein import into nucleus, translocation,GO:0035458~cellular response to interferon-beta,GO:0042993~positive regulation of transcription factor import into nucleus,GO:0045087~innate immune response,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0051607~defense response to virus,GO:0071360~cellular response to exogenous dsRNA,GO:0071407~cellular response to organic cyclic compound, GO:0005741~mitochondrial outer membrane,GO:0005777~peroxisome,GO:0005789~endoplasmic reticulum membrane,GO:0005794~Golgi apparatus,GO:0005886~plasma membrane,GO:0016021~integral component of membrane,GO:0030659~cytoplasmic vesicle membrane,GO:0048471~perinuclear region of cytoplasm, GO:0005515~protein binding,GO:0008134~transcription factor binding,GO:0019901~protein kinase binding,GO:0031625~ubiquitin protein ligase binding,GO:0035438~cyclic-di-GMP binding,GO:0042802~identical protein binding,GO:0042803~protein homodimerization activity,GO:0061507~cyclic-GMP-AMP binding, hsa04622:RIG-I-like receptor signaling pathway,hsa04623:Cytosolic DNA-sensing pathway, 615934~STING-associated vasculopathy, infantile-onset, 3D-structure,Apoptosis,Cell membrane,Complete proteome,Cytoplasm,Disease mutation,Endoplasmic reticulum,Immunity,Innate immunity,Isopeptide bond,Membrane,Mitochondrion,Mitochondrion outer membrane,Nucleotide-binding,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix,Ubl conjugation, chain:Transmembrane protein 173,modified residue,mutagenesis site,sequence conflict,sequence variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region, Q53S58 transmembrane protein 177(TMEM177) Homo sapiens GO:0016021~integral component of membrane, IPR026620:Transmembrane protein 177, Complete proteome,Membrane,Polymorphism,Reference proteome,Transmembrane,Transmembrane helix, chain:Transmembrane protein 177,sequence variant,transmembrane region, Q0P4L9 transmembrane protein 19(tmem19) Xenopus tropicalis GO:0016020~membrane,GO:0016021~integral component of membrane, IPR002794:Protein of unknown function DUF92, TMEM19, Complete proteome,Membrane,Reference proteome,Transmembrane,Transmembrane helix, chain:Transmembrane protein 19,transmembrane region, P57088 transmembrane protein 33(TMEM33) Homo sapiens GO:0034613~cellular protein localization,GO:0034976~response to endoplasmic reticulum stress,GO:0051292~nuclear pore complex assembly,GO:1903371~regulation of endoplasmic reticulum tubular network organization,GO:1903896~positive regulation of IRE1-mediated unfolded protein response,GO:1903899~positive regulation of PERK-mediated unfolded protein response, GO:0005635~nuclear envelope,GO:0005643~nuclear pore,GO:0005783~endoplasmic reticulum,GO:0005789~endoplasmic reticulum membrane,GO:0016021~integral component of membrane,GO:0030176~integral component of endoplasmic reticulum membrane,GO:0042470~melanosome,GO:0070062~extracellular exosome, GO:0005515~protein binding,GO:0017056~structural constituent of nuclear pore, IPR005344:Uncharacterised protein family UPF0121, Acetylation,Complete proteome,Endoplasmic reticulum,Membrane,Nucleus,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix, chain:Transmembrane protein 33,sequence conflict,transmembrane region, Q5U2V9 transmembrane protein 39a(Tmem39a) Rattus norvegicus GO:0002230~positive regulation of defense response to virus by host,GO:0098779~mitophagy in response to mitochondrial depolarization,GO:0098792~xenophagy, GO:0016021~integral component of membrane, IPR019397:Uncharacterised protein family TMEM39, Complete proteome,Glycoprotein,Membrane,Reference proteome,Transmembrane,Transmembrane helix, chain:Transmembrane protein 39A,glycosylation site:N-linked (GlcNAc...),transmembrane region, Q5BJD5 transmembrane protein 41B(TMEM41B) Homo sapiens GO:0007399~nervous system development, GO:0016021~integral component of membrane, IPR015414:SNARE associated Golgi protein, Alternative splicing,Complete proteome,Membrane,Neurogenesis,Phosphoprotein,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix, chain:Transmembrane protein 41B,modified residue,splice variant,transmembrane region, Q8K1A5 transmembrane protein 41B(Tmem41b) Mus musculus GO:0007399~nervous system development, GO:0016020~membrane,GO:0016021~integral component of membrane, IPR015414:SNARE associated Golgi protein, Alternative splicing,Complete proteome,Membrane,Neurogenesis,Phosphoprotein,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix, chain:Transmembrane protein 41B,modified residue,sequence conflict,splice variant,transmembrane region, Q0VCR6 transmembrane protein 68(TMEM68) Bos taurus GO:0008152~metabolic process, GO:0016021~integral component of membrane, GO:0016746~transferase activity, transferring acyl groups, IPR002123:Phospholipid/glycerol acyltransferase, Complete proteome,Membrane,Reference proteome,Transmembrane,Transmembrane helix, chain:Transmembrane protein 68,transmembrane region, Q9D850 transmembrane protein 68(Tmem68) Mus musculus GO:0008152~metabolic process, GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0016746~transferase activity, transferring acyl groups, IPR002123:Phospholipid/glycerol acyltransferase, Alternative splicing,Complete proteome,Membrane,Reference proteome,Transmembrane,Transmembrane helix, chain:Transmembrane protein 68,sequence conflict,splice variant,transmembrane region, A4IF63 tripartite motif containing 2(TRIM2) Bos taurus Carbohydrate transport and metabolism,Posttranslational modification, protein turnover, chaperones, GO:0016567~protein ubiquitination,GO:0043523~regulation of neuron apoptotic process, GO:0005737~cytoplasm, GO:0004842~ubiquitin-protein transferase activity,GO:0008270~zinc ion binding,GO:0016874~ligase activity, IPR000315:Zinc finger, B-box,IPR001258:NHL repeat,IPR001298:Filamin/ABP280 repeat,IPR001841:Zinc finger, RING-type,IPR003649:B-box, C-terminal,IPR011042:Six-bladed beta-propeller, TolB-like,IPR013017:NHL repeat, subgroup,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR017868:Filamin/ABP280 repeat-like,IPR017907:Zinc finger, RING-type, conserved site,IPR027370:RING-type zinc-finger, LisH dimerisation motif, SM00184:RING,SM00336:BBOX,SM00502:BBC,SM00557:IG_FLMN, Complete proteome,Cytoplasm,Ligase,Metal-binding,Phosphoprotein,Reference proteome,Repeat,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, D2GXS7 tripartite motif containing 2(TRIM2) Ailuropoda melanoleuca GO:0043523~regulation of neuron apoptotic process, GO:0005737~cytoplasm, GO:0004842~ubiquitin-protein transferase activity,GO:0008270~zinc ion binding,GO:0016874~ligase activity, IPR000315:Zinc finger, B-box,IPR001258:NHL repeat,IPR001298:Filamin/ABP280 repeat,IPR001841:Zinc finger, RING-type,IPR003649:B-box, C-terminal,IPR011042:Six-bladed beta-propeller, TolB-like,IPR013017:NHL repeat, subgroup,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR017868:Filamin/ABP280 repeat-like,IPR017907:Zinc finger, RING-type, conserved site,IPR027370:RING-type zinc-finger, LisH dimerisation motif, SM00184:RING,SM00336:BBOX,SM00502:BBC,SM00557:IG_FLMN, Complete proteome,Cytoplasm,Ligase,Metal-binding,Phosphoprotein,Reference proteome,Repeat,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, O75382 tripartite motif containing 3(TRIM3) Homo sapiens GO:0007399~nervous system development,GO:0015031~protein transport,GO:0016567~protein ubiquitination, GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0005769~early endosome,GO:0005794~Golgi apparatus,GO:0030425~dendrite, GO:0005515~protein binding,GO:0008022~protein C-terminus binding,GO:0008270~zinc ion binding,GO:0061630~ubiquitin protein ligase activity, IPR000315:Zinc finger, B-box,IPR001258:NHL repeat,IPR001298:Filamin/ABP280 repeat,IPR001841:Zinc finger, RING-type,IPR003649:B-box, C-terminal,IPR011042:Six-bladed beta-propeller, TolB-like,IPR013017:NHL repeat, subgroup,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR017868:Filamin/ABP280 repeat-like,IPR017907:Zinc finger, RING-type, conserved site,IPR027370:RING-type zinc-finger, LisH dimerisation motif, SM00184:RING,SM00336:BBOX,SM00502:BBC,SM00557:IG_FLMN, Acetylation,Alternative splicing,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Endosome,Golgi apparatus,Metal-binding,Phosphoprotein,Polymorphism,Protein transport,Proteomics identification,Reference proteome,Repeat,Signal,Transport,Zinc,Zinc-finger, chain:Tripartite motif-containing protein 3,modified residue,repeat:Filamin,repeat:NHL 1,repeat:NHL 2,repeat:NHL 3,repeat:NHL 4,repeat:NHL 5,repeat:NHL 6,sequence conflict,sequence variant,splice variant,zinc finger region:B box-type,zinc finger region:RING-type, Q5BIM1 tripartite motif containing 45(TRIM45) Bos taurus GO:0060348~bone development, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0045171~intercellular bridge, GO:0008270~zinc ion binding, IPR000315:Zinc finger, B-box,IPR001298:Filamin/ABP280 repeat,IPR001841:Zinc finger, RING-type,IPR003649:B-box, C-terminal,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR017868:Filamin/ABP280 repeat-like,IPR017907:Zinc finger, RING-type, conserved site,IPR027370:RING-type zinc-finger, LisH dimerisation motif, SM00184:RING,SM00336:BBOX,SM00502:BBC,SM00557:IG_FLMN, Coiled coil,Complete proteome,Cytoplasm,Isopeptide bond,Metal-binding,Nucleus,Reference proteome,Repeat,Zinc,Zinc-finger, chain:Tripartite motif-containing protein 45,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),repeat:Filamin,zinc finger region:B box-type 1,zinc finger region:B box-type 2,zinc finger region:RING-type, Q9R1R2 tripartite motif-containing 3(Trim3) Mus musculus GO:0006810~transport,GO:0015031~protein transport,GO:0016567~protein ubiquitination, GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0005768~endosome,GO:0005769~early endosome, GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0046872~metal ion binding,GO:0061630~ubiquitin protein ligase activity, IPR000315:Zinc finger, B-box,IPR001258:NHL repeat,IPR001298:Filamin/ABP280 repeat,IPR001841:Zinc finger, RING-type,IPR003649:B-box, C-terminal,IPR011042:Six-bladed beta-propeller, TolB-like,IPR013017:NHL repeat, subgroup,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR017868:Filamin/ABP280 repeat-like,IPR017907:Zinc finger, RING-type, conserved site,IPR027370:RING-type zinc-finger, LisH dimerisation motif, SM00184:RING,SM00336:BBOX,SM00502:BBC,SM00557:IG_FLMN, Acetylation,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Endosome,Golgi apparatus,Metal-binding,Phosphoprotein,Protein transport,Proteomics identification,Reference proteome,Repeat,Transport,Zinc,Zinc-finger, chain:Tripartite motif-containing protein 3,modified residue,repeat:Filamin,repeat:NHL 1,repeat:NHL 2,repeat:NHL 3,repeat:NHL 4,repeat:NHL 5,repeat:NHL 6,zinc finger region:B box-type,zinc finger region:RING-type, O70277 tripartite motif-containing 3(Trim3) Rattus norvegicus Function unknown, GO:0015031~protein transport,GO:0016567~protein ubiquitination, GO:0005737~cytoplasm,GO:0005769~early endosome,GO:0005794~Golgi apparatus,GO:0030425~dendrite, GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0061630~ubiquitin protein ligase activity, IPR000315:Zinc finger, B-box,IPR001258:NHL repeat,IPR001298:Filamin/ABP280 repeat,IPR001841:Zinc finger, RING-type,IPR003649:B-box, C-terminal,IPR011042:Six-bladed beta-propeller, TolB-like,IPR013017:NHL repeat, subgroup,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR017868:Filamin/ABP280 repeat-like,IPR017907:Zinc finger, RING-type, conserved site,IPR027370:RING-type zinc-finger, LisH dimerisation motif, SM00184:RING,SM00336:BBOX,SM00502:BBC,SM00557:IG_FLMN, Acetylation,Cell projection,Coiled coil,Complete proteome,Cytoplasm,Endosome,Golgi apparatus,Metal-binding,Phosphoprotein,Protein transport,Proteomics identification,Reference proteome,Repeat,Transport,Zinc,Zinc-finger, chain:Tripartite motif-containing protein 3,modified residue,repeat:Filamin,repeat:NHL 1,repeat:NHL 2,repeat:NHL 3,repeat:NHL 4,repeat:NHL 5,repeat:NHL 6,zinc finger region:B box-type,zinc finger region:RING-type, Q1PSW8 tripartite motif-containing 71(Trim71) Mus musculus GO:0000082~G1/S transition of mitotic cell cycle,GO:0001843~neural tube closure,GO:0007275~multicellular organism development,GO:0008543~fibroblast growth factor receptor signaling pathway,GO:0010586~miRNA metabolic process,GO:0017148~negative regulation of translation,GO:0021915~neural tube development,GO:0031047~gene silencing by RNA,GO:0035278~miRNA mediated inhibition of translation,GO:0051246~regulation of protein metabolic process,GO:0051865~protein autoubiquitination,GO:0060964~regulation of gene silencing by miRNA,GO:0061158~3'-UTR-mediated mRNA destabilization,GO:0071310~cellular response to organic substance,GO:0072089~stem cell proliferation,GO:2000177~regulation of neural precursor cell proliferation,GO:2000637~positive regulation of gene silencing by miRNA, GO:0000932~cytoplasmic mRNA processing body,GO:0005622~intracellular,GO:0005737~cytoplasm, GO:0003723~RNA binding,GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0030371~translation repressor activity,GO:0035198~miRNA binding,GO:0046872~metal ion binding,GO:0061630~ubiquitin protein ligase activity, IPR000315:Zinc finger, B-box,IPR001258:NHL repeat,IPR001298:Filamin/ABP280 repeat,IPR001841:Zinc finger, RING-type,IPR011042:Six-bladed beta-propeller, TolB-like,IPR013017:NHL repeat, subgroup,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR013783:Immunoglobulin-like fold,IPR014756:Immunoglobulin E-set,IPR017868:Filamin/ABP280 repeat-like,IPR017907:Zinc finger, RING-type, conserved site, mmu05206:MicroRNAs in cancer, SM00184:RING,SM00336:BBOX,SM00557:IG_FLMN, Acetylation,Coiled coil,Complete proteome,Cytoplasm,Developmental protein,Ligase,Metal-binding,Reference proteome,Repeat,RNA-binding,RNA-mediated gene silencing,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, chain:Tripartite motif-containing protein 71,compositionally biased region:Ser-rich,repeat:Filamin,repeat:NHL 1,repeat:NHL 2,repeat:NHL 3,repeat:NHL 4,repeat:NHL 5,repeat:NHL 6,zinc finger region:B box-type 1; atypical,zinc finger region:B box-type 2,zinc finger region:RING-type, Q8AYG3 ttk protein kinase(ttk) Danio rerio GO:0006468~protein phosphorylation,GO:0007049~cell cycle,GO:0007060~male meiosis chromosome segregation,GO:0007093~mitotic cell cycle checkpoint,GO:0009790~embryo development,GO:0016310~phosphorylation,GO:0016321~female meiosis chromosome segregation,GO:0031101~fin regeneration,GO:0042246~tissue regeneration,GO:0051301~cell division,GO:0051304~chromosome separation,GO:0060249~anatomical structure homeostasis, GO:0000166~nucleotide binding,GO:0004672~protein kinase activity,GO:0004674~protein serine/threonine kinase activity,GO:0004712~protein serine/threonine/tyrosine kinase activity,GO:0004713~protein tyrosine kinase activity,GO:0005524~ATP binding,GO:0016301~kinase activity,GO:0016740~transferase activity,GO:0046872~metal ion binding, IPR000719:Protein kinase, catalytic domain,IPR008271:Serine/threonine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR011990:Tetratricopeptide-like helical,IPR017441:Protein kinase, ATP binding site,IPR027084:Dual specificity protein kinase TTK, dre04110:Cell cycle, SM00220:S_TKc, ATP-binding,Cell cycle,Cell division,Complete proteome,Kinase,Magnesium,Metal-binding,Nucleotide-binding,Proteomics identification,Reference proteome,Serine/threonine-protein kinase,Transferase,Tyrosine-protein kinase, active site:Proton acceptor,binding site:ATP,chain:Dual specificity protein kinase TTK,compositionally biased region:Poly-Ser,domain:Protein kinase,mutagenesis site,nucleotide phosphate-binding region:ATP,sequence conflict, Q9BTW9 tubulin folding cofactor D(TBCD) Homo sapiens Posttranslational modification, protein turnover, chaperones / Cytoskeleton, GO:0006457~protein folding,GO:0007021~tubulin complex assembly,GO:0007023~post-chaperonin tubulin folding pathway,GO:0010812~negative regulation of cell-substrate adhesion,GO:0031115~negative regulation of microtubule polymerization,GO:0034333~adherens junction assembly,GO:0043547~positive regulation of GTPase activity,GO:0070830~bicellular tight junction assembly, GO:0005737~cytoplasm,GO:0005874~microtubule,GO:0005912~adherens junction,GO:0005923~bicellular tight junction,GO:0016328~lateral plasma membrane, GO:0005096~GTPase activator activity,GO:0005515~protein binding,GO:0048487~beta-tubulin binding,GO:0051087~chaperone binding, IPR011989:Armadillo-like helical,IPR016024:Armadillo-type fold,IPR022577:Tubulin-specific chaperone D, C-terminal, Alternative splicing,Cell junction,Cell membrane,Chaperone,Complete proteome,Cytoplasm,GTPase activation,Membrane,Polymorphism,Proteomics identification,Reference proteome,Repeat,Tight junction, chain:Tubulin-specific chaperone D,repeat:HEAT 1,repeat:HEAT 2,repeat:HEAT 3,sequence conflict,sequence variant,splice variant, A9CPT4 tudor domain containing 1(tdrd1) Oryzias latipes GO:0007275~multicellular organism development,GO:0007281~germ cell development,GO:0007283~spermatogenesis,GO:0031047~gene silencing by RNA,GO:0034587~piRNA metabolic process,GO:0043046~DNA methylation involved in gamete generation,GO:0051321~meiotic cell cycle, GO:0043186~P granule,GO:0071546~pi-body, GO:0046872~metal ion binding, IPR002893:Zinc finger, MYND-type,IPR002999:Tudor domain, SM00333:TUDOR, Complete proteome,Cytoplasm,Developmental protein,Differentiation,Meiosis,Metal-binding,Reference proteome,Repeat,RNA-mediated gene silencing,Zinc,Zinc-finger, chain:Tudor domain-containing protein 1,domain:Tudor 1,domain:Tudor 2,domain:Tudor 3,domain:Tudor 4,zinc finger region:MYND-type, Q9WVF8 tumor suppressor candidate 2(Tusc2) Mus musculus GO:0001779~natural killer cell differentiation,GO:0006909~phagocytosis,GO:0006954~inflammatory response,GO:0032618~interleukin-15 production,GO:0032700~negative regulation of interleukin-17 production,GO:0032733~positive regulation of interleukin-10 production,GO:0048469~cell maturation,GO:0050829~defense response to Gram-negative bacterium,GO:0051881~regulation of mitochondrial membrane potential,GO:0052567~response to defense-related host reactive oxygen species production,GO:0070945~neutrophil mediated killing of gram-negative bacterium,GO:0071609~chemokine (C-C motif) ligand 5 production,GO:2000377~regulation of reactive oxygen species metabolic process, GO:0005739~mitochondrion, Complete proteome,Lipoprotein,Myristate,Phosphoprotein,Proteomics identification,Reference proteome, chain:Tumor suppressor candidate 2,lipid moiety-binding region:N-myristoyl glycine,modified residue, Q6TGS6 tyrosyl-tRNA synthetase(yars) Danio rerio Translation, ribosomal structure and biogenesis, GO:0006412~translation,GO:0006418~tRNA aminoacylation for protein translation,GO:0006437~tyrosyl-tRNA aminoacylation,GO:0006438~valyl-tRNA aminoacylation,GO:0006974~cellular response to DNA damage stimulus, GO:0005737~cytoplasm,GO:0005829~cytosol, GO:0000049~tRNA binding,GO:0000166~nucleotide binding,GO:0003723~RNA binding,GO:0004812~aminoacyl-tRNA ligase activity,GO:0004831~tyrosine-tRNA ligase activity,GO:0004832~valine-tRNA ligase activity,GO:0005524~ATP binding,GO:0016874~ligase activity, IPR002305:Aminoacyl-tRNA synthetase, class Ic,IPR002307:Tyrosine-tRNA ligase,IPR002547:tRNA-binding domain,IPR012340:Nucleic acid-binding, OB-fold,IPR014729:Rossmann-like alpha/beta/alpha sandwich fold,IPR023617:Tyrosine-tRNA ligase, archaeal/eukaryotic-type, dre00970:Aminoacyl-tRNA biosynthesis, PIRSF006588:tyrosine tRNA ligase, archaeal/eukaryotic types, Aminoacyl-tRNA synthetase,ATP-binding,Complete proteome,Cytoplasm,Ligase,Nucleotide-binding,Protein biosynthesis,Proteomics identification,Reference proteome,RNA-binding,tRNA-binding, binding site:Tyrosine,chain:Tyrosyl-tRNA synthetase, cytoplasmic,domain:tRNA-binding,sequence conflict,short sequence motif:"HIGH" region,short sequence motif:"KMSKS" region, Q9FHQ6 ubiquitin 9(UBQ9) Arabidopsis thaliana GO:0006464~cellular protein modification process,GO:0006511~ubiquitin-dependent protein catabolic process,GO:0009735~response to cytokinin, GO:0005618~cell wall,GO:0005622~intracellular,GO:0005730~nucleolus,GO:0005774~vacuolar membrane,GO:0005794~Golgi apparatus, IPR000626:Ubiquitin,IPR019954:Ubiquitin conserved site,IPR019956:Ubiquitin subgroup, SM00213:UBQ, Complete proteome,Cytoplasm,Isopeptide bond,Nucleus,Reference proteome,Repeat,Ubl conjugation pathway, Q5EAE3 ubiquitin domain containing 2(UBTD2) Bos taurus GO:0005737~cytoplasm, GO:0043130~ubiquitin binding, IPR000626:Ubiquitin, Complete proteome,Cytoplasm,Reference proteome, chain:Ubiquitin domain-containing protein 2,domain:Ubiquitin-like, Q6PGH0 ubiquitin domain containing 2(Ubtd2) Mus musculus GO:0005737~cytoplasm, GO:0043130~ubiquitin binding, IPR000626:Ubiquitin, SM00213:UBQ, Complete proteome,Cytoplasm,Reference proteome, chain:Ubiquitin domain-containing protein 2,domain:Ubiquitin-like,sequence conflict, F1QJX5 ubiquitin protein ligase E3 component n-recognin 3(ubr3) Danio rerio GO:0008270~zinc ion binding, IPR001841:Zinc finger, RING-type,IPR013083:Zinc finger, RING/FYVE/PHD-type, Complete proteome,Proteomics identification,Reference proteome,Signal, Q5T4S7 ubiquitin protein ligase E3 component n-recognin 4(UBR4) Homo sapiens GO:0016032~viral process,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005813~centrosome,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0005516~calmodulin binding,GO:0008270~zinc ion binding,GO:0016874~ligase activity, IPR003126:Zinc finger, N-recognin,IPR016024:Armadillo-type fold,IPR017986:WD40-repeat-containing domain,IPR025704:E3 ubiquitin ligase, UBR4, hsa05203:Viral carcinogenesis, SM00396:ZnF_UBR1, Acetylation,Alternative splicing,Calmodulin-binding,Complete proteome,Cytoplasm,Cytoskeleton,Direct protein sequencing,Host-virus interaction,Ligase,Membrane,Metal-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Transmembrane,Transmembrane helix,Ubl conjugation pathway,Zinc,Zinc-finger, chain:E3 ubiquitin-protein ligase UBR4,compositionally biased region:Poly-Ala,compositionally biased region:Poly-Asp,compositionally biased region:Pro-rich,compositionally biased region:Ser-rich,modified residue,sequence conflict,sequence variant,splice variant,transmembrane region,zinc finger region:UBR-type, Q80TP3 ubiquitin protein ligase E3 component n-recognin 5(Ubr5) Mus musculus GO:0000209~protein polyubiquitination,GO:0006281~DNA repair,GO:0006974~cellular response to DNA damage stimulus,GO:0010628~positive regulation of gene expression,GO:0031647~regulation of protein stability,GO:0033160~positive regulation of protein import into nucleus, translocation,GO:0035413~positive regulation of catenin import into nucleus,GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process,GO:0050847~progesterone receptor signaling pathway,GO:0090263~positive regulation of canonical Wnt signaling pathway,GO:1901315~negative regulation of histone H2A K63-linked ubiquitination,GO:1905077~negative regulation of interleukin-17 secretion,GO:2000780~negative regulation of double-strand break repair, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0016020~membrane,GO:0043234~protein complex,GO:0048471~perinuclear region of cytoplasm, GO:0003723~RNA binding,GO:0004842~ubiquitin-protein transferase activity,GO:0005515~protein binding,GO:0008270~zinc ion binding,GO:0016740~transferase activity,GO:0016874~ligase activity,GO:0034450~ubiquitin-ubiquitin ligase activity,GO:0043130~ubiquitin binding,GO:0046872~metal ion binding, IPR000569:HECT,IPR002004:Polyadenylate-binding protein/Hyperplastic disc protein,IPR003126:Zinc finger, N-recognin,IPR009091:Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II,IPR024725:E3 ubiquitin ligase EDD, ubiquitin-associated domain, mmu04120:Ubiquitin mediated proteolysis, SM00119:HECTc,SM00396:ZnF_UBR1,SM00517:PolyA, Acetylation,Complete proteome,DNA damage,DNA repair,Metal-binding,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Transferase,Ubl conjugation pathway,Zinc,Zinc-finger, active site:Glycyl thioester intermediate,chain:E3 ubiquitin-protein ligase UBR5,compositionally biased region:Arg/Asp-rich (mixed charge),compositionally biased region:Arg/Glu-rich (mixed charge),compositionally biased region:Asp/Glu-rich (acidic),compositionally biased region:Poly-Ala,compositionally biased region:Poly-Glu,compositionally biased region:Poly-Leu,compositionally biased region:Poly-Ser,compositionally biased region:Pro-rich,compositionally biased region:Ser-rich,domain:HECT,domain:PABC,modified residue,sequence conflict,zinc finger region:UBR-type, O94966 ubiquitin specific peptidase 19(USP19) Homo sapiens GO:0006511~ubiquitin-dependent protein catabolic process,GO:0016579~protein deubiquitination,GO:0030433~ER-associated ubiquitin-dependent protein catabolic process,GO:0031647~regulation of protein stability,GO:0034976~response to endoplasmic reticulum stress,GO:0048642~negative regulation of skeletal muscle tissue development,GO:0050821~protein stabilization,GO:0071108~protein K48-linked deubiquitination,GO:0090068~positive regulation of cell cycle process,GO:1900037~regulation of cellular response to hypoxia,GO:1901799~negative regulation of proteasomal protein catabolic process,GO:1904292~regulation of ERAD pathway, GO:0005789~endoplasmic reticulum membrane,GO:0005829~cytosol,GO:0016021~integral component of membrane, GO:0004843~thiol-dependent ubiquitin-specific protease activity,GO:0005515~protein binding,GO:0031625~ubiquitin protein ligase binding,GO:0036459~thiol-dependent ubiquitinyl hydrolase activity,GO:0046872~metal ion binding,GO:0051879~Hsp90 protein binding,GO:1990380~Lys48-specific deubiquitinase activity, IPR001394:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,IPR002893:Zinc finger, MYND-type,IPR007052:CS-like domain,IPR008978:HSP20-like chaperone,IPR018200:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site, 3D-structure,Alternative splicing,Complete proteome,Endoplasmic reticulum,Hydrolase,Membrane,Metal-binding,Phosphoprotein,Polymorphism,Protease,Proteomics identification,Reference proteome,Repeat,Thiol protease,Transmembrane,Transmembrane helix,Ubl conjugation pathway,Zinc,Zinc-finger, chain:Ubiquitin carboxyl-terminal hydrolase 19,domain:CS 1,domain:CS 2,helix,modified residue,sequence conflict,sequence variant,splice variant,strand,turn,zinc finger region:MYND-type, P0C8Z3 ubiquitin specific peptidase 22(USP22) Bos taurus GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0006511~ubiquitin-dependent protein catabolic process,GO:0007049~cell cycle,GO:0016574~histone ubiquitination,GO:0016578~histone deubiquitination,GO:0043967~histone H4 acetylation,GO:0045893~positive regulation of transcription, DNA-templated,GO:0045931~positive regulation of mitotic cell cycle, GO:0000124~SAGA complex, GO:0004843~thiol-dependent ubiquitin-specific protease activity,GO:0008270~zinc ion binding,GO:0010485~H4 histone acetyltransferase activity,GO:0019899~enzyme binding,GO:0030374~ligand-dependent nuclear receptor transcription coactivator activity, IPR001394:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,IPR001607:Zinc finger, UBP-type,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR018200:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site, Acetylation,Activator,Cell cycle,Chromatin regulator,Complete proteome,Hydrolase,Metal-binding,Nucleus,Protease,Reference proteome,Thiol protease,Transcription,Transcription regulation,Ubl conjugation pathway,Zinc,Zinc-finger, chain:Ubiquitin carboxyl-terminal hydrolase 22,modified residue,zinc finger region:UBP-type, E7F6T8 ubiquitin specific peptidase 37(usp37) Danio rerio GO:0000082~G1/S transition of mitotic cell cycle,GO:0006508~proteolysis,GO:0006511~ubiquitin-dependent protein catabolic process,GO:0007049~cell cycle,GO:0007067~mitotic nuclear division,GO:0016579~protein deubiquitination,GO:0021551~central nervous system morphogenesis,GO:0035871~protein K11-linked deubiquitination,GO:0051301~cell division,GO:0071108~protein K48-linked deubiquitination, GO:0004197~cysteine-type endopeptidase activity,GO:0004843~thiol-dependent ubiquitin-specific protease activity,GO:0008233~peptidase activity,GO:0008234~cysteine-type peptidase activity,GO:0016787~hydrolase activity,GO:0036459~thiol-dependent ubiquitinyl hydrolase activity, IPR001394:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,IPR003903:Ubiquitin interacting motif,IPR018200:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site, SM00726:UIM, Cell cycle,Cell division,Coiled coil,Complete proteome,Hydrolase,Mitosis,Protease,Proteomics identification,Reference proteome,Repeat,Thiol protease,Ubl conjugation pathway, P56399 ubiquitin specific peptidase 5 (isopeptidase T)(Usp5) Mus musculus Posttranslational modification, protein turnover, chaperones, GO:0006508~proteolysis,GO:0006511~ubiquitin-dependent protein catabolic process,GO:0016579~protein deubiquitination,GO:0032436~positive regulation of proteasomal ubiquitin-dependent protein catabolic process,GO:0071108~protein K48-linked deubiquitination, GO:0004843~thiol-dependent ubiquitin-specific protease activity,GO:0005515~protein binding,GO:0008233~peptidase activity,GO:0008234~cysteine-type peptidase activity,GO:0008270~zinc ion binding,GO:0016787~hydrolase activity,GO:0036459~thiol-dependent ubiquitinyl hydrolase activity,GO:0043130~ubiquitin binding,GO:0046872~metal ion binding, IPR001394:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,IPR001607:Zinc finger, UBP-type,IPR009060:UBA-like,IPR013083:Zinc finger, RING/FYVE/PHD-type,IPR015940:Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote,IPR016652:Ubiquitinyl hydrolase,IPR018200:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site, PIRSF016308:ubiquitin-specific protease (ubiquitin carboxyl-terminal hydrolase), SM00165:UBA,SM00290:ZnF_UBP, Acetylation,Complete proteome,Disulfide bond,Hydrolase,Metal-binding,Phosphoprotein,Protease,Proteomics identification,Reference proteome,Repeat,Thiol protease,Ubl conjugation pathway,Zinc,Zinc-finger, chain:Ubiquitin carboxyl-terminal hydrolase 5,domain:UBA 1,domain:UBA 2,modified residue,zinc finger region:UBP-type, P40818 ubiquitin specific peptidase 8(USP8) Homo sapiens GO:0000281~mitotic cytokinesis,GO:0006511~ubiquitin-dependent protein catabolic process,GO:0007032~endosome organization,GO:0008283~cell proliferation,GO:0016579~protein deubiquitination,GO:0038128~ERBB2 signaling pathway,GO:0070536~protein K63-linked deubiquitination,GO:0071108~protein K48-linked deubiquitination,GO:0098609~cell-cell adhesion, GO:0005654~nucleoplasm,GO:0005737~cytoplasm,GO:0005769~early endosome,GO:0005794~Golgi apparatus,GO:0005829~cytosol,GO:0005913~cell-cell adherens junction,GO:0019897~extrinsic component of plasma membrane,GO:0030496~midbody,GO:0031313~extrinsic component of endosome membrane, GO:0004197~cysteine-type endopeptidase activity,GO:0004843~thiol-dependent ubiquitin-specific protease activity,GO:0005515~protein binding,GO:0017124~SH3 domain binding,GO:0036459~thiol-dependent ubiquitinyl hydrolase activity,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR001394:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,IPR001763:Rhodanese-like domain,IPR015063:Domain of unknown function DUF1873,IPR018200:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site, hsa04144:Endocytosis, 3D-structure,Alternative splicing,Cell cycle,Cell membrane,Coiled coil,Complete proteome,Cytoplasm,Endosome,Hydrolase,Membrane,Nucleus,Phosphoprotein,Polymorphism,Protease,Proteomics identification,Reference proteome,SH3-binding,Thiol protease,Ubl conjugation,Ubl conjugation pathway, chain:Ubiquitin carboxyl-terminal hydrolase 8,domain:Rhodanese,helix,modified residue,sequence conflict,sequence variant,short sequence motif:SH3-binding,strand,turn, A1ZAJ2 unc-104 ortholog (C. elegans)(unc-104) Drosophila melanogaster GO:0007018~microtubule-based movement,GO:0007411~axon guidance,GO:0007528~neuromuscular junction development,GO:0008088~axo-dendritic transport,GO:0008089~anterograde axonal transport,GO:0008345~larval locomotory behavior,GO:0016188~synaptic vesicle maturation,GO:0016192~vesicle-mediated transport,GO:0032024~positive regulation of insulin secretion,GO:0040012~regulation of locomotion,GO:0045886~negative regulation of synaptic growth at neuromuscular junction,GO:0046847~filopodium assembly,GO:0047496~vesicle transport along microtubule,GO:0048489~synaptic vesicle transport,GO:0048490~anterograde synaptic vesicle transport,GO:0048814~regulation of dendrite morphogenesis,GO:0051963~regulation of synapse assembly, GO:0005871~kinesin complex,GO:0005874~microtubule,GO:0005875~microtubule associated complex,GO:0030424~axon,GO:0030425~dendrite,GO:1904115~axon cytoplasm, GO:0003777~microtubule motor activity,GO:0005524~ATP binding,GO:0008017~microtubule binding,GO:0016887~ATPase activity, IPR000253:Forkhead-associated (FHA) domain,IPR001752:Kinesin, motor domain,IPR001849:Pleckstrin homology domain,IPR008984:SMAD/FHA domain,IPR011993:Pleckstrin homology-like domain,IPR019821:Kinesin, motor region, conserved site,IPR022140:Kinesin protein 1B,IPR022164:Kinesin-like,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00129:KISc,SM00233:PH,SM00240:FHA, Alternative splicing,ATP-binding,Coiled coil,Complete proteome,Cytoplasm,Cytoskeleton,Microtubule,Motor protein,Nucleotide-binding,Phosphoprotein,Reference proteome, chain:Kinesin-like protein unc-104,domain:FHA,domain:Kinesin-motor,domain:PH,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict,splice variant, Q9Z1N9 unc-13 homolog B (C. elegans)(Unc13b) Mus musculus GO:0006887~exocytosis,GO:0007268~chemical synaptic transmission,GO:0007528~neuromuscular junction development,GO:0010808~positive regulation of synaptic vesicle priming,GO:0016081~synaptic vesicle docking,GO:0016082~synaptic vesicle priming,GO:0031914~negative regulation of synaptic plasticity,GO:0035249~synaptic transmission, glutamatergic,GO:0035556~intracellular signal transduction,GO:0043065~positive regulation of apoptotic process,GO:0045921~positive regulation of exocytosis,GO:0048172~regulation of short-term neuronal synaptic plasticity,GO:0050714~positive regulation of protein secretion,GO:0060384~innervation,GO:0071333~cellular response to glucose stimulus,GO:0090382~phagosome maturation,GO:0097151~positive regulation of inhibitory postsynaptic potential,GO:1900426~positive regulation of defense response to bacterium, GO:0005622~intracellular,GO:0005737~cytoplasm,GO:0005794~Golgi apparatus,GO:0005829~cytosol,GO:0005886~plasma membrane,GO:0016020~membrane,GO:0030054~cell junction,GO:0031594~neuromuscular junction,GO:0032009~early phagosome,GO:0043195~terminal bouton,GO:0044305~calyx of Held,GO:0045202~synapse,GO:0048786~presynaptic active zone,GO:0097060~synaptic membrane,GO:0097470~ribbon synapse,GO:0098793~presynapse, GO:0001566~non-kinase phorbol ester receptor activity,GO:0005516~calmodulin binding,GO:0017075~syntaxin-1 binding,GO:0019905~syntaxin binding,GO:0019992~diacylglycerol binding,GO:0030742~GTP-dependent protein binding,GO:0046872~metal ion binding, IPR000008:C2 calcium-dependent membrane targeting,IPR002219:Protein kinase C-like, phorbol ester/diacylglycerol binding,IPR010439:Calcium-dependent secretion activator,IPR014770:Munc13 homology 1,IPR014772:Mammalian uncoordinated homology 13, domain 2,IPR019558:Mammalian uncoordinated homology 13, subgroup, domain 2,IPR020454:Diacylglycerol/phorbol-ester binding,IPR027080:Uncoordinated protein 13 (Unc-13), mmu04721:Synaptic vesicle cycle, SM00109:C1,SM00239:C2,SM01145:SM01145, Alternative splicing,Cell junction,Coiled coil,Complete proteome,Cytoplasm,Exocytosis,Golgi apparatus,Membrane,Metal-binding,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Synapse,Zinc,Zinc-finger, chain:Protein unc-13 homolog B,domain:C2 1,domain:C2 2,domain:C2 3,domain:MHD1,domain:MHD2,modified residue,zinc finger region:Phorbol-ester/DAG-type, Q70J99 unc-13 homolog D(UNC13D) Homo sapiens GO:0002432~granuloma formation,GO:0002467~germinal center formation,GO:0006909~phagocytosis,GO:0043304~regulation of mast cell degranulation,GO:0043320~natural killer cell degranulation,GO:0045921~positive regulation of exocytosis,GO:0051607~defense response to virus,GO:1900026~positive regulation of substrate adhesion-dependent cell spreading,GO:1903307~positive regulation of regulated secretory pathway, GO:0005764~lysosome,GO:0005770~late endosome,GO:0016020~membrane,GO:0033093~Weibel-Palade body,GO:0055037~recycling endosome,GO:0070382~exocytic vesicle, GO:0005515~protein binding,GO:0017137~Rab GTPase binding, IPR000008:C2 calcium-dependent membrane targeting,IPR014770:Munc13 homology 1,IPR014772:Mammalian uncoordinated homology 13, domain 2,IPR019558:Mammalian uncoordinated homology 13, subgroup, domain 2, 608898~Hemophagocytic lymphohistiocytosis, familial, 3, SM00239:C2, Alternative splicing,Complete proteome,Cytoplasm,Endosome,Exocytosis,Familial hemophagocytic lymphohistiocytosis,Lysosome,Membrane,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat, chain:Protein unc-13 homolog D,domain:C2 1,domain:C2 2,domain:MHD1,domain:MHD2,modified residue,mutagenesis site,region of interest:Interaction with RAB27A,sequence conflict,sequence variant,splice variant, A0A1B0GVH7 uncharacterized LOC285423(LOC285423) Homo sapiens Complete proteome,Reference proteome, Q6NYU7 uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)(uprt) Danio rerio GO:0009116~nucleoside metabolic process, GO:0005634~nucleus,GO:0005737~cytoplasm, GO:0000166~nucleotide binding,GO:0005525~GTP binding, IPR000836:Phosphoribosyltransferase domain, dre00240:Pyrimidine metabolism,dre01100:Metabolic pathways, Complete proteome,Cytoplasm,GTP-binding,Nucleotide-binding,Nucleus,Proteomics identification,Reference proteome, chain:Uracil phosphoribosyltransferase, P47941 v-crk avian sarcoma virus CT10 oncogene homolog-like(Crkl) Mus musculus m_gleevecPathway:Inhibition of Cellular Proliferation by Gleevec,m_il2rbPathway:IL-2 Receptor Beta Chain in T cell Activation,m_integrinPathway:Integrin Signaling Pathway,m_metPathway:Signaling of Hepatocyte Growth Factor Receptor,m_pyk2Pathway:Links between Pyk2 and Map Kinases, GO:0001568~blood vessel development,GO:0007389~pattern specification process,GO:0007507~heart development,GO:0008284~positive regulation of cell proliferation,GO:0009887~organ morphogenesis,GO:0009952~anterior/posterior pattern specification,GO:0048538~thymus development,GO:0060017~parathyroid gland development,GO:1900026~positive regulation of substrate adhesion-dependent cell spreading, GO:0005737~cytoplasm,GO:0005913~cell-cell adherens junction,GO:0070062~extracellular exosome, GO:0005515~protein binding,GO:0044822~poly(A) RNA binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000980:SH2 domain,IPR001452:Src homology-3 domain,IPR011511:Variant SH3, mmu04010:MAPK signaling pathway,mmu04012:ErbB signaling pathway,mmu04015:Rap1 signaling pathway,mmu04062:Chemokine signaling pathway,mmu04510:Focal adhesion,mmu04666:Fc gamma R-mediated phagocytosis,mmu04722:Neurotrophin signaling pathway,mmu04810:Regulation of actin cytoskeleton,mmu04910:Insulin signaling pathway,mmu05100:Bacterial invasion of epithelial cells,mmu05200:Pathways in cancer,mmu05206:MicroRNAs in cancer,mmu05211:Renal cell carcinoma,mmu05220:Chronic myeloid leukemia, SM00252:SH2,SM00326:SH3, Complete proteome,Phosphoprotein,Reference proteome,Repeat,SH2 domain,SH3 domain, chain:Crk-like protein,domain:SH2,domain:SH3 1,domain:SH3 2,modified residue,sequence conflict, P09324 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1(YES1) Gallus gallus GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway,GO:0015758~glucose transport,GO:0030154~cell differentiation,GO:0036120~cellular response to platelet-derived growth factor stimulus,GO:0038083~peptidyl-tyrosine autophosphorylation,GO:0042127~regulation of cell proliferation,GO:0045087~innate immune response,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0048013~ephrin receptor signaling pathway,GO:0050731~positive regulation of peptidyl-tyrosine phosphorylation,GO:0071300~cellular response to retinoic acid,GO:0071560~cellular response to transforming growth factor beta stimulus, GO:0005794~Golgi apparatus,GO:0005815~microtubule organizing center,GO:0005829~cytosol,GO:0005884~actin filament,GO:0005925~focal adhesion,GO:0031234~extrinsic component of cytoplasmic side of plasma membrane,GO:0070062~extracellular exosome, GO:0004715~non-membrane spanning protein tyrosine kinase activity,GO:0005102~receptor binding,GO:0005524~ATP binding,GO:0019899~enzyme binding,GO:0044325~ion channel binding, IPR000719:Protein kinase, catalytic domain,IPR000980:SH2 domain,IPR001245:Serine-threonine/tyrosine-protein kinase catalytic domain,IPR001452:Src homology-3 domain,IPR008266:Tyrosine-protein kinase, active site,IPR011009:Protein kinase-like domain,IPR017441:Protein kinase, ATP binding site,IPR020635:Tyrosine-protein kinase, catalytic domain, gga04520:Adherens junction, SM00219:TyrKc,SM00252:SH2,SM00326:SH3, ATP-binding,Cell membrane,Complete proteome,Cytoplasm,Cytoskeleton,Kinase,Lipoprotein,Membrane,Myristate,Nucleotide-binding,Palmitate,Phosphoprotein,Reference proteome,SH2 domain,SH3 domain,Transferase,Tyrosine-protein kinase, active site:Proton acceptor,binding site:ATP,chain:Tyrosine-protein kinase Yes,domain:Protein kinase,domain:SH2,domain:SH3,lipid moiety-binding region:N-myristoyl glycine,modified residue,nucleotide phosphate-binding region:ATP,sequence conflict, Q5THJ4 vacuolar protein sorting 13 homolog D(VPS13D) Homo sapiens Intracellular trafficking and secretion, GO:0006623~protein targeting to vacuole,GO:0045053~protein retention in Golgi apparatus, GO:0005622~intracellular,GO:0019898~extrinsic component of membrane,GO:0070062~extracellular exosome, IPR009060:UBA-like,IPR009543:Vacuolar protein sorting-associated protein 13 domain,IPR015940:Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote,IPR026847:Vacuolar protein sorting-associated protein 13,IPR026854:Vacuolar protein sorting-associated protein 13A N-terminal domain, SM00165:UBA, Acetylation,Alternative splicing,Complete proteome,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome, chain:Vacuolar protein sorting-associated protein 13D,domain:UBA,modified residue,sequence conflict,sequence variant,splice variant, Q6NWF4 vacuolar protein sorting 25 homolog (S. cerevisiae)(vps25) Danio rerio GO:0006810~transport,GO:0015031~protein transport,GO:0043328~protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, GO:0000814~ESCRT II complex,GO:0005737~cytoplasm, GO:0005198~structural molecule activity,GO:0042803~protein homodimerization activity, IPR008570:ESCRT-II complex, vps25 subunit,IPR011991:Winged helix-turn-helix DNA-binding domain,IPR014041:ESCRT-II complex, Vps25 subunit, N-terminal winged helix, dre04144:Endocytosis, Complete proteome,Cytoplasm,Protein transport,Proteomics identification,Reference proteome,Transport, chain:Vacuolar protein-sorting-associated protein 25, Q155U0 vacuolar protein sorting 51 homolog (S. cerevisiae)(vps51) Danio rerio GO:0006810~transport,GO:0006869~lipid transport,GO:0007030~Golgi organization,GO:0010517~regulation of phospholipase activity,GO:0015031~protein transport,GO:0032456~endocytic recycling,GO:0044241~lipid digestion,GO:0048193~Golgi vesicle transport, GO:0000938~GARP complex,GO:0005768~endosome,GO:0005794~Golgi apparatus,GO:0055037~recycling endosome,GO:1990745~EARP complex, GO:0030306~ADP-ribosylation factor binding, IPR014812:Vacuolar protein sorting-associated protein 51,IPR016159:Cullin repeat-like-containing domain, Coiled coil,Complete proteome,Endosome,Golgi apparatus,Lipid transport,Protein transport,Proteomics identification,Reference proteome,Transport, chain:Protein fat-free, Q15906 vacuolar protein sorting 72 homolog(VPS72) Homo sapiens GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0006351~transcription, DNA-templated,GO:0016569~covalent chromatin modification,GO:0035019~somatic stem cell population maintenance,GO:0043486~histone exchange, GO:0005634~nucleus,GO:0005654~nucleoplasm,GO:0043234~protein complex, GO:0003677~DNA binding,GO:0005515~protein binding, IPR008895:YL1 nuclear,IPR013272:YL1 nuclear, C-terminal, SM00993:SM00993, 3D-structure,Alternative splicing,Chromatin regulator,Complete proteome,DNA-binding,Nucleus,Phosphoprotein,Polymorphism,Reference proteome,Transcription,Transcription regulation, chain:Vacuolar protein sorting-associated protein 72 homolog,compositionally biased region:Asp/Glu-rich (acidic),compositionally biased region:Poly-Pro,compositionally biased region:Pro-rich,modified residue,sequence conflict,sequence variant, P49701 vitamin D (1,25- dihydroxyvitamin D3) receptor(VDR) Coturnix japonica GO:0006351~transcription, DNA-templated, GO:0005634~nucleus, GO:0003707~steroid hormone receptor activity,GO:0008270~zinc ion binding,GO:0008434~calcitriol receptor activity,GO:0043565~sequence-specific DNA binding, IPR000324:Vitamin D receptor,IPR000536:Nuclear hormone receptor, ligand-binding, core,IPR001628:Zinc finger, nuclear hormone receptor-type,IPR001723:Steroid hormone receptor,IPR013088:Zinc finger, NHR/GATA-type, SM00399:ZnF_C4,SM00430:HOLI, Alternative initiation,DNA-binding,Metal-binding,Nucleus,Receptor,Transcription,Transcription regulation,Zinc,Zinc-finger, Q502W6 von Willebrand factor A domain containing 3B(VWA3B) Homo sapiens GO:0005737~cytoplasm, IPR002035:von Willebrand factor, type A, SM00327:VWA, Alternative splicing,Complete proteome,Cytoplasm,Disease mutation,Mental retardation,Neurodegeneration,Polymorphism,Proteomics identification,Reference proteome, chain:von Willebrand factor A domain-containing protein 3B,domain:VWFA,sequence conflict,sequence variant,splice variant, Q6DFV8 von Willebrand factor D and EGF domains(Vwde) Mus musculus GO:0005576~extracellular region, GO:0005509~calcium ion binding, IPR000742:Epidermal growth factor-like domain,IPR001846:von Willebrand factor, type D domain,IPR001881:EGF-like calcium-binding,IPR009030:Insulin-like growth factor binding protein, N-terminal,IPR013032:EGF-like, conserved site,IPR018097:EGF-like calcium-binding, conserved site, SM00179:EGF_CA,SM00181:EGF,SM00216:VWD, Complete proteome,Disulfide bond,EGF-like domain,Reference proteome,Repeat,Secreted,Signal, chain:von Willebrand factor D and EGF domain- containing protein,domain:VWFD,signal peptide, Q5SSZ7 zinc and ring finger 3(Znrf3) Mus musculus Posttranslational modification, protein turnover, chaperones, GO:0006511~ubiquitin-dependent protein catabolic process,GO:0016055~Wnt signaling pathway,GO:0016567~protein ubiquitination,GO:0030178~negative regulation of Wnt signaling pathway,GO:0038018~Wnt receptor catabolic process,GO:0060070~canonical Wnt signaling pathway,GO:0060071~Wnt signaling pathway, planar cell polarity pathway,GO:0072089~stem cell proliferation,GO:0090090~negative regulation of canonical Wnt signaling pathway,GO:2000051~negative regulation of non-canonical Wnt signaling pathway, GO:0005886~plasma membrane,GO:0005887~integral component of plasma membrane,GO:0016020~membrane,GO:0016021~integral component of membrane, GO:0004842~ubiquitin-protein transferase activity,GO:0005109~frizzled binding,GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0046872~metal ion binding, IPR001841:Zinc finger, RING-type,IPR013083:Zinc finger, RING/FYVE/PHD-type, SM00184:RING, 3D-structure,Alternative splicing,Cell membrane,Complete proteome,Ligase,Membrane,Metal-binding,Reference proteome,Signal,Transmembrane,Transmembrane helix,Ubl conjugation pathway,Wnt signaling pathway,Zinc,Zinc-finger, chain:Zinc/RING finger protein 3,compositionally biased region:Arg-rich,sequence conflict,signal peptide,splice variant,topological domain:Cytoplasmic,topological domain:Extracellular,transmembrane region,zinc finger region:RING-type; atypical, Q8R205 zinc finger CCCH type containing 10(Zc3h10) Mus musculus GO:0044822~poly(A) RNA binding,GO:0046872~metal ion binding, IPR000571:Zinc finger, CCCH-type, SM00356:ZnF_C3H1, Coiled coil,Complete proteome,Metal-binding,Methylation,Reference proteome,Repeat,Zinc,Zinc-finger, chain:Zinc finger CCCH domain-containing protein 10,compositionally biased region:Gly-rich,compositionally biased region:Poly-Gly,compositionally biased region:Pro-rich,modified residue,zinc finger region:C3H1-type 1,zinc finger region:C3H1-type 2,zinc finger region:C3H1-type 3, Q8WU90 zinc finger CCCH-type containing 15(ZC3H15) Homo sapiens General function prediction only, GO:0019221~cytokine-mediated signaling pathway,GO:0098609~cell-cell adhesion, GO:0005730~nucleolus,GO:0005737~cytoplasm,GO:0005913~cell-cell adherens junction, GO:0005515~protein binding,GO:0044822~poly(A) RNA binding,GO:0046872~metal ion binding,GO:0098641~cadherin binding involved in cell-cell adhesion, IPR000571:Zinc finger, CCCH-type, SM00356:ZnF_C3H1, Alternative splicing,Coiled coil,Complete proteome,Cytoplasm,Metal-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Repeat,Zinc,Zinc-finger, chain:Zinc finger CCCH domain-containing protein 15,modified residue,region of interest:Required for interaction with DRG1,sequence conflict,sequence variant,zinc finger region:C3H1-type 1,zinc finger region:C3H1-type 2, Q15696 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2(ZRSR2) Homo sapiens GO:0000245~spliceosomal complex assembly,GO:0000398~mRNA splicing, via spliceosome,GO:0008380~RNA splicing, GO:0005689~U12-type spliceosomal complex,GO:0089701~U2AF, GO:0000166~nucleotide binding,GO:0003723~RNA binding,GO:0005515~protein binding,GO:0030628~pre-mRNA 3'-splice site binding,GO:0046872~metal ion binding, IPR000504:RNA recognition motif domain,IPR000571:Zinc finger, CCCH-type,IPR003954:RNA recognition motif domain, eukaryote,IPR009145:U2 auxiliary factor small subunit,IPR012677:Nucleotide-binding, alpha-beta plait, SM00356:ZnF_C3H1,SM00361:RRM_1, Coiled coil,Complete proteome,Metal-binding,mRNA processing,mRNA splicing,Nucleus,Phosphoprotein,Proteomics identification,Reference proteome,Repeat,Ribonucleoprotein,RNA-binding,Spliceosome,Zinc,Zinc-finger, chain:U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2,compositionally biased region:Poly-Glu,domain:RRM,modified residue,zinc finger region:C3H1-type 1,zinc finger region:C3H1-type 2, Q5FWF4 zinc finger RANBP2-type containing 3(ZRANB3) Homo sapiens GO:0000733~DNA strand renaturation,GO:0006281~DNA repair,GO:0006974~cellular response to DNA damage stimulus,GO:0009411~response to UV,GO:0031297~replication fork processing,GO:0036292~DNA rewinding,GO:0045910~negative regulation of DNA recombination,GO:0048478~replication fork protection,GO:0090305~nucleic acid phosphodiester bond hydrolysis, GO:0005634~nucleus,GO:0043596~nuclear replication fork, GO:0003676~nucleic acid binding,GO:0003678~DNA helicase activity,GO:0004386~helicase activity,GO:0004519~endonuclease activity,GO:0004520~endodeoxyribonuclease activity,GO:0005515~protein binding,GO:0005524~ATP binding,GO:0008270~zinc ion binding,GO:0036310~annealing helicase activity,GO:0070530~K63-linked polyubiquitin binding, IPR000330:SNF2-related,IPR001650:Helicase, C-terminal,IPR001876:Zinc finger, RanBP2-type,IPR002711:HNH endonuclease,IPR003615:HNH nuclease,IPR014001:Helicase, superfamily 1/2, ATP-binding domain,IPR027417:P-loop containing nucleoside triphosphate hydrolase, SM00487:DEXDc,SM00490:HELICc,SM00507:HNHc,SM00547:ZnF_RBZ, Alternative splicing,ATP-binding,Chromosome,Complete proteome,DNA damage,DNA repair,Endonuclease,Helicase,Hydrolase,Isopeptide bond,Metal-binding,Multifunctional enzyme,Nuclease,Nucleotide-binding,Nucleus,Phosphoprotein,Polymorphism,Proteomics identification,Reference proteome,Zinc,Zinc-finger, chain:Zinc finger Ran-binding domain-containing protein 3,cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin),domain:Helicase ATP-binding,domain:Helicase C-terminal,nucleotide phosphate-binding region:ATP,sequence variant,short sequence motif:DEAH box,splice variant,zinc finger region:RanBP2-type, Q8NEG5 zinc finger SWIM-type containing 2(ZSWIM2) Homo sapiens GO:0000209~protein polyubiquitination,GO:0006915~apoptotic process,GO:1902043~positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, GO:0008270~zinc ion binding,GO:0016874~ligase activity,GO:0043621~protein self-association,GO:0061630~ubiquitin protein ligase activity, IPR000433:Zinc finger, ZZ-type,IPR001841:Zinc finger, RING-type,IPR007527:Zinc finger, SWIM-type,IPR013083:Zinc finger, RING/FYVE/PHD-type, SM00184:RING, 3D-structure,Apoptosis,Complete proteome,Ligase,Metal-binding,Reference proteome,Repeat,Ubl conjugation,Ubl conjugation pathway,Zinc,Zinc-finger, chain:Zinc finger SWIM domain-containing protein 2,helix,strand,zinc finger region:RING-type 1,zinc finger region:RING-type 2,zinc finger region:SWIM-type,zinc finger region:ZZ-type, Q9UJU3 zinc finger protein 112(ZNF112) Homo sapiens General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005622~intracellular,GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0046872~metal ion binding, IPR001909:Krueppel-associated box,IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00349:KRAB,SM00355:ZnF_C2H2, Alternative splicing,Complete proteome,DNA-binding,Metal-binding,Nucleus,Polymorphism,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 112 homolog,domain:KRAB,sequence conflict,sequence variant,zinc finger region:C2H2-type 10,zinc finger region:C2H2-type 11,zinc finger region:C2H2-type 12,zinc finger region:C2H2-type 13,zinc finger region:C2H2-type 14,zinc finger region:C2H2-type 15,zinc finger region:C2H2-type 16,zinc finger region:C2H2-type 17,zinc finger region:C2H2-type 1; degenerate,zinc finger region:C2H2-type 2; degenerate,zinc finger region:C2H2-type 3; degenerate,zinc finger region:C2H2-type 4; degenerate,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, Q0VAW7 zinc finger protein 112(Zfp112) Mus musculus General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005622~intracellular,GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0046872~metal ion binding, IPR001909:Krueppel-associated box,IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00349:KRAB,SM00355:ZnF_C2H2, Alternative splicing,Complete proteome,DNA-binding,Metal-binding,Nucleus,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 112,domain:KRAB,sequence conflict,splice variant,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 10,zinc finger region:C2H2-type 11,zinc finger region:C2H2-type 12,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, O70230 zinc finger protein 143(Zfp143) Mus musculus General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0045944~positive regulation of transcription from RNA polymerase II promoter,GO:0048661~positive regulation of smooth muscle cell proliferation, GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003682~chromatin binding,GO:0046872~metal ion binding, IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00355:ZnF_C2H2, Acetylation,Activator,Alternative splicing,Complete proteome,DNA-binding,Metal-binding,Nucleus,Phosphoprotein,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 143,sequence conflict,splice variant,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7, O43345 zinc finger protein 208(ZNF208) Homo sapiens General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005622~intracellular,GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0008270~zinc ion binding,GO:0046872~metal ion binding, IPR001909:Krueppel-associated box,IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00349:KRAB,SM00355:ZnF_C2H2, Alternative splicing,Complete proteome,DNA-binding,Metal-binding,Nucleus,Polymorphism,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, Q86WZ6 zinc finger protein 227(ZNF227) Homo sapiens General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0045892~negative regulation of transcription, DNA-templated, GO:0005622~intracellular,GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0005515~protein binding,GO:0046872~metal ion binding, IPR001909:Krueppel-associated box,IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00349:KRAB,SM00355:ZnF_C2H2, Alternative splicing,Complete proteome,DNA-binding,Metal-binding,Nucleus,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 227,domain:KRAB,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 10,zinc finger region:C2H2-type 11,zinc finger region:C2H2-type 12,zinc finger region:C2H2-type 13,zinc finger region:C2H2-type 14,zinc finger region:C2H2-type 15,zinc finger region:C2H2-type 16,zinc finger region:C2H2-type 17,zinc finger region:C2H2-type 18,zinc finger region:C2H2-type 19,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, Q14590 zinc finger protein 235(ZNF235) Homo sapiens General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005622~intracellular,GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0046872~metal ion binding, IPR001909:Krueppel-associated box,IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00349:KRAB,SM00355:ZnF_C2H2, Alternative splicing,Complete proteome,DNA-binding,Metal-binding,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 235,domain:KRAB,sequence conflict,sequence variant,splice variant,zinc finger region:C2H2-type 10,zinc finger region:C2H2-type 11,zinc finger region:C2H2-type 12,zinc finger region:C2H2-type 13,zinc finger region:C2H2-type 14,zinc finger region:C2H2-type 15,zinc finger region:C2H2-type 16,zinc finger region:C2H2-type 1; degenerate,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, Q9UL36 zinc finger protein 236(ZNF236) Homo sapiens General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0071333~cellular response to glucose stimulus, GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0046872~metal ion binding, IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00355:ZnF_C2H2, Alternative splicing,Complete proteome,DNA-binding,Metal-binding,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Repeat,Signal,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 236,sequence variant,splice variant,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 10,zinc finger region:C2H2-type 11,zinc finger region:C2H2-type 12,zinc finger region:C2H2-type 13,zinc finger region:C2H2-type 14,zinc finger region:C2H2-type 15,zinc finger region:C2H2-type 16,zinc finger region:C2H2-type 17,zinc finger region:C2H2-type 18,zinc finger region:C2H2-type 19,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 20,zinc finger region:C2H2-type 21,zinc finger region:C2H2-type 22,zinc finger region:C2H2-type 23,zinc finger region:C2H2-type 24,zinc finger region:C2H2-type 25,zinc finger region:C2H2-type 26,zinc finger region:C2H2-type 27,zinc finger region:C2H2-type 28,zinc finger region:C2H2-type 29,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 30,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, P10076 zinc finger protein 26(Zfp26) Mus musculus General function prediction only, GO:0006355~regulation of transcription, DNA-templated, GO:0005622~intracellular,GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0046872~metal ion binding, IPR001909:Krueppel-associated box,IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00349:KRAB,SM00355:ZnF_C2H2, Complete proteome,DNA-binding,Metal-binding,Nucleus,Reference proteome,Repeat,Zinc,Zinc-finger, chain:Zinc finger protein 26,domain:KRAB,sequence conflict,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 10,zinc finger region:C2H2-type 11,zinc finger region:C2H2-type 12,zinc finger region:C2H2-type 13,zinc finger region:C2H2-type 14,zinc finger region:C2H2-type 15,zinc finger region:C2H2-type 16,zinc finger region:C2H2-type 17,zinc finger region:C2H2-type 18,zinc finger region:C2H2-type 19,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 20,zinc finger region:C2H2-type 21,zinc finger region:C2H2-type 22,zinc finger region:C2H2-type 23; degenerate,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, Q9NRM2 zinc finger protein 277(ZNF277) Homo sapiens GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0070301~cellular response to hydrogen peroxide,GO:2000772~regulation of cellular senescence, GO:0005634~nucleus, GO:0000979~RNA polymerase II core promoter sequence-specific DNA binding,GO:0003676~nucleic acid binding,GO:0046872~metal ion binding, IPR007087:Zinc finger, C2H2,IPR015880:Zinc finger, C2H2-like, SM00355:ZnF_C2H2, Acetylation,Coiled coil,Complete proteome,DNA-binding,Metal-binding,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 277,sequence variant,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 2, Q8TF32 zinc finger protein 431(ZNF431) Homo sapiens General function prediction only, GO:0000122~negative regulation of transcription from RNA polymerase II promoter,GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated,GO:0030154~cell differentiation,GO:0043433~negative regulation of sequence-specific DNA binding transcription factor activity, GO:0005622~intracellular,GO:0005634~nucleus, GO:0000978~RNA polymerase II core promoter proximal region sequence-specific DNA binding,GO:0001046~core promoter sequence-specific DNA binding,GO:0003676~nucleic acid binding,GO:0003682~chromatin binding,GO:0046872~metal ion binding, IPR001909:Krueppel-associated box,IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like,IPR026613:KRAB domain C2H2 zinc finger family, SM00349:KRAB,SM00355:ZnF_C2H2, Complete proteome,Differentiation,DNA-binding,Metal-binding,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Repeat,Repressor,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 431,domain:KRAB,sequence conflict,sequence variant,zinc finger region:C2H2-type 10,zinc finger region:C2H2-type 11,zinc finger region:C2H2-type 12,zinc finger region:C2H2-type 13,zinc finger region:C2H2-type 1; degenerate,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, B0BLT0 zinc finger protein 593(znf593) Xenopus tropicalis GO:0003676~nucleic acid binding,GO:0008270~zinc ion binding, IPR003604:Zinc finger, U1-type,IPR007087:Zinc finger, C2H2,IPR022755:Zinc finger, double-stranded RNA binding, SM00451:ZnF_U1, Complete proteome,Metal-binding,Reference proteome,Zinc,Zinc-finger, chain:Zinc finger protein 593,zinc finger region:C2H2-type, Q8IYB9 zinc finger protein 595(ZNF595) Homo sapiens General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005622~intracellular,GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0046872~metal ion binding, IPR001909:Krueppel-associated box,IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00349:KRAB,SM00355:ZnF_C2H2, Complete proteome,DNA-binding,Metal-binding,Nucleus,Polymorphism,Proteomics identification,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 595,domain:KRAB,sequence variant,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 10,zinc finger region:C2H2-type 11,zinc finger region:C2H2-type 12,zinc finger region:C2H2-type 13,zinc finger region:C2H2-type 14,zinc finger region:C2H2-type 15,zinc finger region:C2H2-type 16,zinc finger region:C2H2-type 17,zinc finger region:C2H2-type 18,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, Q9NQZ8 zinc finger protein 71(ZNF71) Homo sapiens General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005634~nucleus, GO:0003677~DNA binding,GO:0003700~transcription factor activity, sequence-specific DNA binding,GO:0046872~metal ion binding, IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00355:ZnF_C2H2, Complete proteome,DNA-binding,Metal-binding,Nucleus,Polymorphism,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Endothelial zinc finger protein induced by tumor necrosis factor alpha,sequence variant,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 10,zinc finger region:C2H2-type 11,zinc finger region:C2H2-type 12,zinc finger region:C2H2-type 13,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9, Q5REI6 zinc finger protein 791(ZNF791) Pongo abelii General function prediction only, GO:0006351~transcription, DNA-templated,GO:0006355~regulation of transcription, DNA-templated, GO:0005622~intracellular,GO:0005634~nucleus, GO:0003676~nucleic acid binding,GO:0003677~DNA binding,GO:0046872~metal ion binding, IPR001909:Krueppel-associated box,IPR007087:Zinc finger, C2H2,IPR013087:Zinc finger C2H2-type/integrase DNA-binding domain,IPR015880:Zinc finger, C2H2-like, SM00349:KRAB,SM00355:ZnF_C2H2, Complete proteome,DNA-binding,Metal-binding,Nucleus,Reference proteome,Repeat,Transcription,Transcription regulation,Zinc,Zinc-finger, chain:Zinc finger protein 791,domain:KRAB,zinc finger region:C2H2-type 1,zinc finger region:C2H2-type 10,zinc finger region:C2H2-type 11,zinc finger region:C2H2-type 12,zinc finger region:C2H2-type 13,zinc finger region:C2H2-type 14,zinc finger region:C2H2-type 15,zinc finger region:C2H2-type 16,zinc finger region:C2H2-type 17,zinc finger region:C2H2-type 2,zinc finger region:C2H2-type 3,zinc finger region:C2H2-type 4,zinc finger region:C2H2-type 5,zinc finger region:C2H2-type 6,zinc finger region:C2H2-type 7,zinc finger region:C2H2-type 8,zinc finger region:C2H2-type 9,