TR17601_c2_g1_i1 21.881 12.764 103.641 0.000 3.569 72.170 Q8TDM0 BCAS4_HUMAN 8.00E-10 GO:0005737 cytoplasm IPR024857; Breast carcinoma-amplified sequence 4 BCAS4 Homo sapiens (Human) TR18955_c1_g1_i2 0.005 0.000 0.000 2.081 7.749 0.000 P86854 PLCL_MYTGA 7.00E-22 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR21000_c0_g2_i1 561.130 136.416 0.882 0.000 0.000 247.125 P41366 VMO1_CHICK 2.00E-09 GO:0005576; GO:0030704 extracellular region; vitelline membrane formation IPR005515; Vitelline membrane outer layer protein 1 (VMO-1) (VMO-I) (VMOI) VMO1 Gallus gallus (Chicken) TR21084_c0_g1_i1 3.167 28.490 0.000 123.405 138.028 152.674 P22031 LEG_ANTCR 2.00E-07 GO:0030246; GO:0005737 carbohydrate binding; cytoplasm IPR000922; D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR23191_c0_g1_i1 0.000 0.000 0.000 0.022 0.386 17.638 A7YWP4 HUTH_BOVIN 4.00E-94 GO:0009058; GO:0005737; GO:0004397; GO:0019556; GO:0019557 biosynthetic process; cytoplasm; histidine ammonia-lyase activity; histidine catabolic process to glutamate and formamide; histidine catabolic process to glutamate and formate IPR001106; IPR024083; IPR005921; IPR008948; IPR022313; Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3. Histidine ammonia-lyase (Histidase) (EC 4.3.1.3) HAL Bos taurus (Bovine) TR23345_c0_g5_i1 0.426 565.869 489.772 214.592 38.651 1277.822 P62278 RS13_RAT 2.00E-98 GO:0022627; GO:0003735; GO:0006412 cytosolic small ribosomal subunit; structural constituent of ribosome; translation IPR012606; IPR000589; IPR023029; IPR009068; 40S ribosomal protein S13 Rps13 Rattus norvegicus (Rat) TR23860_c0_g1_i1 0.031 0.050 0.000 0.060 11.914 0.147 Q54468 CHB_SERMA 4.00E-69 GO:0004563; GO:0006032; GO:0042597; GO:0030247; GO:0000272 beta-N-acetylhexosaminidase activity; chitin catabolic process; periplasmic space; polysaccharide binding; polysaccharide catabolic process IPR025705; IPR008965; IPR012291; IPR004866; IPR004867; IPR013812; IPR015883; IPR015882; IPR013781; IPR017853; IPR014756; Glycan degradation; chitin degradation. Chitobiase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (N-acetyl-beta-glucosaminidase) chb Serratia marcescens TR25615_c0_g2_i1 0.000 0.000 0.000 0.951 5.097 0.000 Q6DFV8 VWDE_MOUSE 5.00E-11 GO:0005576 extracellular region IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) TR26636_c3_g1_i1 0.172 0.000 0.000 0.000 0.052 26.581 P86854 PLCL_MYTGA 4.00E-15 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR26787_c0_g1_i3 0.000 133.833 1.716 0.000 0.468 1.913 P22897 MRC1_HUMAN 5.00E-07 GO:0010008; GO:0005887; GO:0005537; GO:0004872; GO:0006898 endosome membrane; integral to plasma membrane; mannose binding; receptor activity; receptor-mediated endocytosis IPR001304; IPR016186; IPR018378; IPR016187; IPR000562; IPR013806; IPR000772; Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) TR27085_c0_g1_i1 96.663 18.767 3.981 0.193 0.320 1.963 P86854 PLCL_MYTGA 6.00E-14 GO:0030246; GO:0005576 carbohydrate binding; extracellular region IPR001304; IPR016186; IPR018378; IPR016187; Perlucin-like protein Mytilus galloprovincialis (Mediterranean mussel) TR27145_c0_g1_i1 0.000 0.118 0.284 3.546 1.042 0.004 Q0EEE2 PTHD3_MOUSE 2.00E-43 GO:0008158; GO:0016021 hedgehog receptor activity; integral to membrane IPR003392; IPR000731; Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) TR27227_c0_g1_i1 3.300 0.000 2.191 0.215 0.503 85.809 Q00PJ9 CAV1_ATEAB 4.00E-29 GO:0000139; GO:0031295; GO:0005901; GO:0005768 Golgi membrane; T cell costimulation; caveola; endosome IPR001612; IPR015504; IPR018361; Caveolin-1 CAV1 Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog) TR27331_c0_g1_i2 10.807 40.239 245.343 0.072 5.736 1.071 Q01519 COX12_YEAST 6.00E-12 GO:0004129; GO:0005758; GO:0005751; GO:0033617 cytochrome-c oxidase activity; mitochondrial intermembrane space; mitochondrial respiratory chain complex IV; mitochondrial respiratory chain complex IV assembly IPR003213; Cytochrome c oxidase subunit 6B (Cytochrome c oxidase polypeptide VIb) COX12 YLR038C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR27580_c0_g1_i2 1.134 0.452 228.063 0.277 2.317 1.581 P67884 RL30_OPHHA 6.00E-65 GO:0005840; GO:0003735; GO:0006412 ribosome; structural constituent of ribosome; translation IPR000231; IPR022991; IPR004038; 60S ribosomal protein L30 RPL30 Ophiophagus hannah (King cobra) (Naja hannah) TR27611_c1_g1_i1 0.000 0.729 0.193 10.081 9.351 0.112 Q96RW7 HMCN1_HUMAN 2.00E-55 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR27755_c0_g1_i2 274.055 3.597 2.033 0.062 0.296 0.508 Q66KU2 SC61G_XENLA 2.00E-25 GO:0015450; GO:0005789; GO:0016021; GO:0045047; GO:0008565 P-P-bond-hydrolysis-driven protein transmembrane transporter activity; endoplasmic reticulum membrane; integral to membrane; protein targeting to ER; protein transporter activity IPR023391; IPR008158; IPR001901; Protein transport protein Sec61 subunit gamma sec61g Xenopus laevis (African clawed frog) TR28414_c0_g1_i3 0.000 0.000 32.491 0.000 1.846 66.074 Q94051 CAV1_CAEEL 7.00E-17 GO:0000139; GO:0007265; GO:0005901; GO:0005938; GO:0060473; GO:0005887; GO:0009898; GO:0007126; GO:0048471; GO:0046662; GO:0030133 Golgi membrane; Ras protein signal transduction; caveola; cell cortex; cortical granule; integral to plasma membrane; internal side of plasma membrane; meiosis; perinuclear region of cytoplasm; regulation of oviposition; transport vesicle IPR001612; Caveolin-1 cav-1 T13F2.8 Caenorhabditis elegans TR28434_c0_g1_i1 19.649 0.570 9.835 0.000 0.256 0.000 O43396 TXNL1_HUMAN 5.00E-106 GO:0045454; GO:0005737; GO:0015036; GO:0006662; GO:0005634; GO:0000502; GO:0015035 cell redox homeostasis; cytoplasm; disulfide oxidoreductase activity; glycerol ether metabolic process; nucleus; proteasome complex; protein disulfide oxidoreductase activity IPR008979; IPR010400; IPR005746; IPR012336; IPR017937; IPR013766; Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein) TXNL1 TRP32 TXL TXNL Homo sapiens (Human) TR28460_c0_g3_i5 0.000 0.000 6.403 0.000 0.587 0.000 Q9D5V6 SYAP1_MOUSE 4.00E-47 GO:0005634 nucleus IPR005607; Synapse-associated protein 1 Syap1 Mus musculus (Mouse) TR28581_c0_g1_i1 0.000 0.148 0.000 0.053 9.449 0.009 Q6IWZ0 OXLA_APLCA 4.00E-69 GO:0001716; GO:0042742; GO:0050832; GO:0005576; GO:0031640 L-amino-acid oxidase activity; defense response to bacterium; defense response to fungus; extracellular region; killing of cells of other organism IPR002937; L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (Escapin) Aplysia californica (California sea hare) TR28652_c1_g1_i3 26.006 22.702 0.000 3.455 11.670 6.034 A0SYQ0 PTGES_CANFA 6.00E-18 GO:0005737; GO:0043295; GO:0016021; GO:0008285; GO:0005641; GO:0001516; GO:0050220 cytoplasm; glutathione binding; integral to membrane; negative regulation of cell proliferation; nuclear envelope lumen; prostaglandin biosynthetic process; prostaglandin-E synthase activity IPR023352; IPR001129; Prostaglandin E synthase (EC 5.3.99.3) (Microsomal prostaglandin E synthase 1) (MPGES-1) PTGES PGES Canis familiaris (Dog) (Canis lupus familiaris) TR29597_c9_g1_i1 26.182 15.135 145.645 0.000 3.321 70.337 Q86U02 CN165_HUMAN 5.00E-21 GO:0016021 integral to membrane Putative uncharacterized protein encoded by LINC00596 LINC00596 C14orf165 Homo sapiens (Human) TR29606_c0_g1_i2 9.938 7.026 0.228 0.582 1.404 0.000 Q9WV92 E41L3_MOUSE 7.00E-140 GO:0006915; GO:0005911; GO:0030866; GO:0030865; GO:0005737; GO:0007016; GO:0005856; GO:0019898; GO:0044224; GO:0043217; GO:0048812; GO:0030913; GO:0033270; GO:0005886; GO:0071205; GO:0002175; GO:0072659; GO:0008360; GO:0005200 apoptotic process; cell-cell junction; cortical actin cytoskeleton organization; cortical cytoskeleton organization; cytoplasm; cytoskeletal anchoring at plasma membrane; cytoskeleton; extrinsic to membrane; juxtaparanode region of axon; myelin maintenance; neuron projection morphogenesis; paranodal junction assembly; paranode region of axon; plasma membrane; protein localization to juxtaparanode region of axon; protein localization to paranode region of axon; protein localization to plasma membrane; regulation of cell shape; structural constituent of cytoskeleton IPR008379; IPR019749; IPR019750; IPR021187; IPR000798; IPR014847; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; IPR007477; "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) TR30028_c0_g1_i1 36.562 0.656 1.184 0.000 1.461 0.619 Q8IUK8 CBLN2_HUMAN 6.00E-08 GO:0005615; GO:0051965 extracellular space; positive regulation of synapse assembly IPR001073; IPR008983; Cerebellin-2 CBLN2 UNQ1892/PRO4338 Homo sapiens (Human) TR30303_c1_g1_i3 5.531 16.651 4.778 0.000 1.069 11.658 Q8QGW7 LITAF_CHICK 1.00E-17 GO:0005125; GO:0005737; GO:0006355; GO:0006351 "cytokine activity; cytoplasm; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR006629; Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) TR30755_c0_g4_i2 3.135 1.466 0.000 13.311 7.230 0.135 Q9D4D4 TKTL2_MOUSE 0 GO:0046872; GO:0004802 metal ion binding; transketolase activity IPR009014; IPR005475; IPR020826; IPR005476; IPR005474; Transketolase-like protein 2 (EC 2.2.1.1) Tktl2 Mus musculus (Mouse) TR30770_c5_g2_i1 0.004 0.022 0.438 5.442 0.349 0.000 Q6DFV8 VWDE_MOUSE 8.00E-25 GO:0005576 extracellular region IPR013032; IPR001846; von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) TR30866_c0_g1_i1 1.814 0.857 62.372 0.729 0.000 0.000 Q8TGM7 ART2_YEAST 4.00E-30 Putative uncharacterized protein ART2 (Antisense to ribosomal RNA transcript protein 2) ART2 YLR154W-A YLR154W-C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR30962_c0_g1_i1 9.311 18.382 7.945 0.000 0.248 12.238 O65154 KIWI_ARATH 8.00E-14 GO:0003677; GO:0005634; GO:0006355; GO:0003713; GO:0006351 O65155 "DNA binding; nucleus; regulation of transcription, DNA-dependent; transcription coactivator activity; transcription, DNA-dependent" IPR003173; IPR009044; RNA polymerase II transcriptional coactivator KIWI KIWI At5g09250 T5E8_50 Arabidopsis thaliana (Mouse-ear cress) TR31051_c0_g2_i1 0.389 0.371 0.812 7.993 0.983 0.000 O88967 YMEL1_MOUSE 0 GO:0005524; GO:0008283; GO:0016021; GO:0046872; GO:0004222; GO:0006515; GO:0005743; GO:0007005; GO:0017111 ATP binding; cell proliferation; integral to membrane; metal ion binding; metalloendopeptidase activity; misfolded or incompletely synthesized protein catabolic process; mitochondrial inner membrane; mitochondrion organization; nucleoside-triphosphatase activity IPR003593; IPR003959; IPR003960; IPR005936; IPR027417; IPR000642; ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (YME1-like protein 1) Yme1l1 Mus musculus (Mouse) TR31137_c4_g2_i1 0.000 0.000 19.676 0.984 1.332 38.251 A6H6E2 MMRN2_MOUSE 9.00E-07 GO:0001525; GO:0005604; GO:0005615; GO:0090051; GO:0030948 angiogenesis; basement membrane; extracellular space; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of vascular endothelial growth factor receptor signaling pathway IPR001073; IPR011489; IPR008983; Multimerin-2 Mmrn2 Mus musculus (Mouse) TR31158_c0_g1_i2 0.000 0.000 8.674 0.000 0.000 0.000 Q0APM5 KYNB_MARMM 2.00E-06 GO:0043420; GO:0004061; GO:0004328; GO:0019441 anthranilate metabolic process; arylformamidase activity; formamidase activity; tryptophan catabolic process to kynurenine IPR007325; IPR017484; Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF) kynB Mmar10_1470 Maricaulis maris (strain MCS10) TR31197_c1_g2_i12 0.000 0.001 0.000 3.431 0.041 0.000 P48380 RFX3_HUMAN 0 GO:0003705; GO:0048469; GO:0060285; GO:0042384; GO:0031018; GO:0060287; GO:0045892; GO:0000790; GO:0045944; GO:2000078; GO:0050796; GO:0005667; GO:0044212; GO:0072560 "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; cell maturation; ciliary cell motility; cilium assembly; endocrine pancreas development; epithelial cilium movement involved in determination of left/right asymmetry; negative regulation of transcription, DNA-dependent; nuclear chromatin; positive regulation of transcription from RNA polymerase II promoter; positive regulation of type B pancreatic cell development; regulation of insulin secretion; transcription factor complex; transcription regulatory region DNA binding; type B pancreatic cell maturation" IPR003150; IPR007668; IPR011991; Transcription factor RFX3 (Regulatory factor X 3) RFX3 Homo sapiens (Human) TR31482_c3_g3_i1 70.246 8.404 0.052 0.000 0.000 0.000 P25067 CO8A2_HUMAN 3.00E-08 GO:0001525; GO:0005604; GO:0048593; GO:0016337; GO:0005581; GO:0030574; GO:0005788; GO:0050673; GO:0022617; GO:0005201; GO:0030674 "angiogenesis; basement membrane; camera-type eye morphogenesis; cell-cell adhesion; collagen; collagen catabolic process; endoplasmic reticulum lumen; epithelial cell proliferation; extracellular matrix disassembly; extracellular matrix structural constituent; protein binding, bridging" IPR001073; IPR008160; IPR008983; Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) TR31685_c1_g1_i3 0.625 0.000 1.103 9.799 4.958 0.509 Q9VCA2 ORCT_DROME 2.00E-81 GO:0006915; GO:0016021; GO:0006811; GO:0022857 apoptotic process; integral to membrane; ion transport; transmembrane transporter activity IPR020846; IPR016196; IPR005828; Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) TR31878_c0_g2_i2 47.931 21.242 13.411 9.293 19.337 0.000 Q9VAL0 SPCS1_DROME 5.00E-23 GO:0016021; GO:0008233; GO:0006508; GO:0005787; GO:0006465 integral to membrane; peptidase activity; proteolysis; signal peptidase complex; signal peptide processing IPR009542; Signal peptidase complex subunit 1 (EC 3.4.-.-) (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) Spase12 CG11500 Drosophila melanogaster (Fruit fly) TR31968_c2_g1_i1 2.265 4.290 0.000 5.569 13.435 13.218 Q26636 CATL_SARPE 8.00E-121 GO:0030154; GO:0008234; GO:0005764; GO:0007275; GO:0006508 cell differentiation; cysteine-type peptidase activity; lysosome; multicellular organismal development; proteolysis IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR013201; Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) TR31989_c0_g1_i3 0.021 1.205 39.142 3.453 12.006 0.051 P63182 CBLN1_RAT 3.00E-08 GO:0030054; GO:0005576; GO:0051965; GO:0045211; GO:0009306 cell junction; extracellular region; positive regulation of synapse assembly; postsynaptic membrane; protein secretion IPR001073; IPR008983; Cerebellin-1 (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin (des-Ser(1)-cerebellin) ([des-Ser1]CER) (des-CER) (des-Ser1CER)] Cbln1 Rattus norvegicus (Rat) TR32001_c1_g1_i2 30.172 0.533 0.068 0.052 0.414 140.346 P23438 SSRB_CANFA 4.00E-73 GO:0005789; GO:0016021 endoplasmic reticulum membrane; integral to membrane IPR008856; Translocon-associated protein subunit beta (TRAP-beta) (Glycoprotein 25H) (gp25H) (Signal sequence receptor subunit beta) (SSR-beta) SSR2 Canis familiaris (Dog) (Canis lupus familiaris) TR32355_c0_g1_i1 16.179 0.067 0.015 0.000 0.000 23.569 P83425 HIP_MYTED 2.00E-32 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR32355_c0_g1_i2 156.871 320.469 167.587 23.233 17.567 0.000 P83425 HIP_MYTED 7.00E-34 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR32355_c0_g1_i3 0.100 242.700 3.682 0.000 0.359 0.046 Q6UW01 CBLN3_HUMAN 1.00E-07 GO:0005794; GO:0030054; GO:0005783; GO:0005615; GO:0045202 Golgi apparatus; cell junction; endoplasmic reticulum; extracellular space; synapse IPR001073; IPR008983; Cerebellin-3 CBLN3 UNQ755/PRO1486 Homo sapiens (Human) TR32747_c0_g1_i2 31.463 12.972 0.000 5.037 12.912 3.445 Q7JQD3 GELS1_LUMTE 5.00E-122 GO:0003779; GO:0051693; GO:0030043; GO:0030041; GO:0051014; GO:0045010; GO:0005509; GO:0005737; GO:0005856; GO:0007275 actin binding; actin filament capping; actin filament fragmentation; actin filament polymerization; actin filament severing; actin nucleation; calcium ion binding; cytoplasm; cytoskeleton; multicellular organismal development IPR007123; IPR007122; Gelsolin-like protein 1 (Actin-modulator) (EWAM) (EWAM-P1) AM Lumbricus terrestris (Common earthworm) TR32860_c0_g2_i1 208.981 2.313 0.250 0.167 0.000 2.096 Q9R045 ANGL2_MOUSE 4.00E-49 GO:0005576 extracellular region IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 2 (Angiopoietin-like protein 2) Angptl2 Arp2 Mus musculus (Mouse) TR32890_c1_g2_i2 5.610 2.412 0.000 0.000 0.208 0.162 Q16629 SRSF7_HUMAN 3.00E-33 GO:0003723; GO:0031124; GO:0006406; GO:0000398; GO:0048025; GO:0005654; GO:0000166; GO:0006369; GO:0008270 Q9UBU9; Q7Z6E9; Q9JKL7; Q96SB4; P78362 "RNA binding; mRNA 3'-end processing; mRNA export from nucleus; mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; termination of RNA polymerase II transcription; zinc ion binding" IPR012677; IPR000504; IPR001878; "Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Homo sapiens (Human) TR32890_c1_g2_i8 0.000 1.441 2.209 1.897 2.363 4.106 Q16629 SRSF7_HUMAN 3.00E-33 GO:0003723; GO:0031124; GO:0006406; GO:0000398; GO:0048025; GO:0005654; GO:0000166; GO:0006369; GO:0008270 Q9UBU9; Q7Z6E9; Q9JKL7; Q96SB4; P78362 "RNA binding; mRNA 3'-end processing; mRNA export from nucleus; mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; termination of RNA polymerase II transcription; zinc ion binding" IPR012677; IPR000504; IPR001878; "Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Homo sapiens (Human) TR33065_c0_g1_i3 0.209 0.095 9.750 0.000 0.000 8.016 P82890 PPAC1_DROME 4.00E-38 GO:0003993; GO:0005737; GO:0004726; GO:0004725 acid phosphatase activity; cytoplasm; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine phosphatase activity IPR023485; IPR002115; IPR000106; IPR017867; Low molecular weight phosphotyrosine protein phosphatase 1 (EC 3.1.3.48) (Low molecular weight cytosolic acid phosphatase 1) (EC 3.1.3.2) (PTPase 1) primo-1 CG31311 Drosophila melanogaster (Fruit fly) TR33286_c7_g2_i9 0.000 5.975 7.264 0.000 4.962 7.858 P22031 LEG_ANTCR 5.00E-11 GO:0030246; GO:0005737 carbohydrate binding; cytoplasm IPR000922; D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) TR33384_c0_g2_i15 0.000 62.737 0.000 0.000 0.304 0.000 Q7LZR2 CO8A1_CHICK 6.00E-13 GO:0001525; GO:0005604; GO:0007155; GO:0005581 angiogenesis; basement membrane; cell adhesion; collagen IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain COL8A1 Gallus gallus (Chicken) TR33384_c0_g2_i4 1.988 0.123 0.000 3.784 46.067 0.058 Q06577 HP27_TAMSI 2.00E-06 GO:0005581; GO:0042750 collagen; hibernation IPR001073; IPR008160; IPR008983; Hibernation-associated plasma protein HP-27 (Hibernator-specific blood complex 27 kDa subunit) Tamias sibiricus (Siberian chipmunk) (Eutamias sibiricus) TR33384_c0_g2_i6 15.244 0.460 0.000 23.812 290.706 1.012 Q7LZR2 CO8A1_CHICK 5.00E-13 GO:0001525; GO:0005604; GO:0007155; GO:0005581 angiogenesis; basement membrane; cell adhesion; collagen IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain COL8A1 Gallus gallus (Chicken) TR33405_c2_g1_i15 0.206 0.617 30.280 0.040 0.175 0.000 Q3E813 YL154_YEAST 1.00E-09 Uncharacterized protein YLR154C-G YLR154C-G smORF421 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR33479_c0_g1_i3 4.887 3.012 0.000 0.000 0.228 2.068 P02642 TNNT2_CHICK 5.00E-10 GO:0006937; GO:0005861 regulation of muscle contraction; troponin complex IPR027707; IPR001978; "Troponin T, cardiac muscle isoforms (TnTC)" TNNT2 Gallus gallus (Chicken) TR33580_c1_g3_i2 0.471 0.000 0.000 2.174 0.934 0.002 Q13367 AP3B2_HUMAN 0 GO:0030123; GO:0030137; GO:0008089; GO:0048490; GO:0030665; GO:0006897; GO:0006886; GO:0005634; GO:0006892; GO:0005215 AP-3 adaptor complex; COPI-coated vesicle; anterograde axon cargo transport; anterograde synaptic vesicle transport; clathrin-coated vesicle membrane; endocytosis; intracellular protein transport; nucleus; post-Golgi vesicle-mediated transport; transporter activity IPR026740; IPR026739; IPR011989; IPR016024; IPR002553; IPR008153; IPR013041; AP-3 complex subunit beta-2 (Adapter-related protein complex 3 subunit beta-2) (Adaptor protein complex AP-3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) AP3B2 Homo sapiens (Human) TR33626_c0_g1_i3 0.875 1.832 0.000 2.911 1.277 1.302 O35501 GRP75_CRIGR 0 GO:0005524; GO:0005739; GO:0005730; GO:0006457 ATP binding; mitochondrion; nucleolus; protein folding IPR012725; IPR018181; IPR013126; "Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9)" HSPA9 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) TR33649_c1_g3_i1 0.281 0.000 0.000 0.000 0.000 37.857 Q751L8 SODC_ASHGO 7.00E-36 GO:0005507; GO:0005829; GO:0005739; GO:0005634; GO:0019430; GO:0004784; GO:0008270 copper ion binding; cytosol; mitochondrion; nucleus; removal of superoxide radicals; superoxide dismutase activity; zinc ion binding IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) SOD1 AGL321W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR33649_c1_g3_i2 8.846 0.205 0.000 0.000 0.162 22.062 P07509 SODC_NEUCR 6.00E-35 GO:0005507; GO:0005829; GO:0005739; GO:0005634; GO:0019430; GO:0004784; GO:0008270 copper ion binding; cytosol; mitochondrion; nucleus; removal of superoxide radicals; superoxide dismutase activity; zinc ion binding IPR024134; IPR018152; IPR001424; Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) sod-1 NCU02133 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) TR33828_c0_g1_i4 0.000 0.000 0.000 8.068 2.602 0.000 G4XV71 C93C2_GLYUR 9.00E-25 GO:0033770; GO:0005783; GO:0020037; GO:0016021; GO:0043231; GO:0005506; GO:0009717; GO:0031090 2-hydroxyisoflavanone synthase activity; endoplasmic reticulum; heme binding; integral to membrane; intracellular membrane-bounded organelle; iron ion binding; isoflavonoid biosynthetic process; organelle membrane IPR001128; IPR017972; IPR002401; 2-hydroxyisoflavanone synthase (2HI synthase) (EC 1.14.13.136) (Cytochrome P450 93C2) (Isoflavonoid synthase) CYP93C2 IFS1 IFS2 Glycyrrhiza uralensis (Chinese licorice) (Glycyrrhiza shiheziensis) TR33901_c1_g2_i2 108.335 85.207 0.000 88.215 193.924 1.323 P35544 UBIM_HUMAN 2.00E-15 IPR019956; IPR019954; IPR000626; Ubiquitin-like protein FUBI FAU Homo sapiens (Human) TR34217_c4_g1_i5 0.000 0.000 0.000 8.228 1.276 0.000 Q9NP72 RAB18_HUMAN 1.00E-30 GO:0019003; GO:0005525; GO:0003924; GO:0007420; GO:0006897; GO:0001654; GO:0005622; GO:0005886; GO:0015031; GO:0007264 Q99IB8 GDP binding; GTP binding; GTPase activity; brain development; endocytosis; eye development; intracellular; plasma membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR025662; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-18 RAB18 Homo sapiens (Human) TR34217_c4_g1_i8 2.091 1.171 0.000 14.413 5.431 0.000 P18067 RAB7A_CANFA 3.00E-124 GO:0005525; GO:0003924; GO:0005794; GO:0045022; GO:0008333; GO:0007174; GO:0005770; GO:0005764; GO:0042470; GO:0045335; GO:0030670; GO:0090383; GO:0090385; GO:0006622; GO:0007264 GTP binding; GTPase activity; Golgi apparatus; early endosome to late endosome transport; endosome to lysosome transport; epidermal growth factor catabolic process; late endosome; lysosome; melanosome; phagocytic vesicle; phagocytic vesicle membrane; phagosome acidification; phagosome-lysosome fusion; protein targeting to lysosome; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-7a RAB7A RAB7 Canis familiaris (Dog) (Canis lupus familiaris) TR34293_c0_g1_i8 0.291 0.000 0.389 55.606 362.051 30.964 P59105 SLEB_OCEIH 2.00E-07 GO:0016787; GO:0008152; GO:0009847; GO:0030435 hydrolase activity; metabolic process; spore germination; sporulation resulting in formation of a cellular spore IPR011105; IPR002477; IPR014224; Spore cortex-lytic enzyme (SCLE) sleB OB1806 Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) TR34316_c7_g2_i2 28.550 93.978 0.575 0.635 25.915 0.000 O70174 ACHA4_MOUSE 7.00E-17 GO:0042113; GO:0006281; GO:0015464; GO:0004889; GO:0005892; GO:0035095; GO:0006816; GO:0030054; GO:0050890; GO:0035640; GO:0009897; GO:0007626; GO:0051899; GO:0045211; GO:0001508; GO:0014059; GO:0060080; GO:0007585; GO:0001666; GO:0006979; GO:0019233; GO:0007271 "B cell activation; DNA repair; acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-gated channel complex; behavioral response to nicotine; calcium ion transport; cell junction; cognition; exploration behavior; external side of plasma membrane; locomotory behavior; membrane depolarization; postsynaptic membrane; regulation of action potential; regulation of dopamine secretion; regulation of inhibitory postsynaptic membrane potential; respiratory gaseous exchange; response to hypoxia; response to oxidative stress; sensory perception of pain; synaptic transmission, cholinergic" IPR027361; IPR006202; IPR006201; IPR006029; IPR018000; IPR002394; Neuronal acetylcholine receptor subunit alpha-4 Chrna4 Acra4 Mus musculus (Mouse) TR34323_c5_g3_i3 0.133 107.056 0.909 0.042 0.470 0.092 Q25379 ACT3_LYTPI 1.00E-112 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, cytoskeletal 3 (LPC3) (Fragment)" Lytechinus pictus (Painted sea urchin) TR34323_c5_g3_i4 119.819 76.917 0.000 0.417 0.791 48.680 P84856 ACTB_CERPY 0 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, cytoplasmic 1 (Beta-actin)" ACTB Cercopithecus pygerythrus (Vervet monkey) TR34323_c5_g3_i5 5.213 1.752 19.037 0.028 0.322 2.072 Q964E3 ACTC_BIOAL 0 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR020902; IPR004001; "Actin, cytoplasmic" Biomphalaria alexandrina (Bloodfluke planorb) (Freshwater snail) TR34323_c5_g3_i6 86.024 1.554 17.423 0.142 0.270 36.259 P10994 ACTS_PLEWA 2.00E-77 GO:0005524; GO:0005737; GO:0005856 ATP binding; cytoplasm; cytoskeleton IPR004000; IPR004001; "Actin, alpha skeletal muscle (Fragment)" Pleurodeles waltl (Iberian ribbed newt) TR34357_c0_g1_i1 1.403 0.088 0.000 24.342 6.069 1.907 Q6LWU0 SYD_METMP 3.00E-57 GO:0005524; GO:0004815; GO:0006422; GO:0005737; GO:0000287; GO:0003676 ATP binding; aspartate-tRNA ligase activity; aspartyl-tRNA aminoacylation; cytoplasm; magnesium ion binding; nucleic acid binding IPR004364; IPR018150; IPR006195; IPR020780; IPR004523; IPR002312; IPR012340; IPR004365; Aspartate--tRNA ligase (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) aspS MMP1616 Methanococcus maripaludis (strain S2 / LL) TR34426_c0_g2_i3 0.000 5.535 0.128 0.100 0.059 0.014 Q7QH73 PERC_ANOGA 1.00E-93 GO:0005576; GO:0020037; GO:0042744; GO:0046872; GO:0004601 extracellular region; heme binding; hydrogen peroxide catabolic process; metal ion binding; peroxidase activity IPR010255; IPR002007; IPR019791; Chorion peroxidase (EC 1.11.1.7) pxt AGAP004038 Anopheles gambiae (African malaria mosquito) TR34437_c0_g2_i1 0.000 0.000 0.000 2.598 0.431 0.120 Q6DFC8 ZN395_XENLA 5.00E-39 GO:0003677; GO:0005737; GO:0046872; GO:0005634; GO:0006355; GO:0006351 "DNA binding; cytoplasm; metal ion binding; nucleus; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR007087; IPR015880; Zinc finger protein 395 znf395 Xenopus laevis (African clawed frog) TR34635_c0_g4_i4 11.600 1.724 0.000 0.000 0.356 0.000 P48809 RB27C_DROME 7.00E-19 GO:0007411; GO:0007298; GO:0005737; GO:0046331; GO:0003730; GO:0048027; GO:0007319; GO:0005654; GO:0000166; GO:0045451; GO:0045727; GO:0043234; GO:0048024; GO:0030529; GO:0003697 "axon guidance; border follicle cell migration; cytoplasm; lateral inhibition; mRNA 3'-UTR binding; mRNA 5'-UTR binding; negative regulation of oskar mRNA translation; nucleoplasm; nucleotide binding; pole plasm oskar mRNA localization; positive regulation of translation; protein complex; regulation of mRNA splicing, via spliceosome; ribonucleoprotein complex; single-stranded DNA binding" IPR012677; IPR000504; Heterogeneous nuclear ribonucleoprotein 27C (Hrb27-C) (HRP48.1) (hnRNP 48) Hrb27C hrp48 Rbp7 CG10377 Drosophila melanogaster (Fruit fly) TR34683_c0_g1_i1 15.070 4.301 0.000 4.390 3.552 8.228 Q5M9I5 QCR6_RAT 5.00E-13 GO:0006122; GO:0005750; GO:0032403; GO:0051291; GO:0008121 "mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrial respiratory chain complex III; protein complex binding; protein heterooligomerization; ubiquinol-cytochrome-c reductase activity" IPR003422; IPR023184; "Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein)" Uqcrh Rattus norvegicus (Rat) TR34809_c2_g2_i1 0.006 0.002 0.001 5.672 0.388 0.000 Q5R8Z8 RAB14_PONAB 2.00E-136 GO:0019003; GO:0005525; GO:0003924; GO:0000139; GO:0006895; GO:0031901; GO:0009790; GO:0032456; GO:0008543; GO:0045335; GO:0030670; GO:0015031; GO:0055037; GO:0032880; GO:0007264 GDP binding; GTP binding; GTPase activity; Golgi membrane; Golgi to endosome transport; early endosome membrane; embryo development; endocytic recycling; fibroblast growth factor receptor signaling pathway; phagocytic vesicle; phagocytic vesicle membrane; protein transport; recycling endosome; regulation of protein localization; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-14 RAB14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR34881_c2_g2_i1 0.000 1.902 3.377 6.176 1.863 0.030 Q16956 GRP78_APLCA 0 GO:0005524; GO:0005788 ATP binding; endoplasmic reticulum lumen IPR018181; IPR013126; 78 kDa glucose-regulated protein (GRP-78) (BiP) (Protein 1603) Aplysia californica (California sea hare) TR34919_c0_g1_i1 0.017 0.031 0.000 15.665 6.338 0.127 Q90953 CSPG2_CHICK 4.00E-26 GO:0005509; GO:0030246; GO:0007155; GO:0005540; GO:0005578 calcium ion binding; carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Gallus gallus (Chicken) TR34930_c3_g1_i4 0.000 0.029 17.062 0.046 0.745 0.000 Q29116 TENA_PIG 8.00E-53 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR000742; IPR013032; IPR013111; IPR014716; IPR014715; IPR002181; IPR003961; IPR013783; Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (P230) (Tenascin-C) (TN-C) TNC HXB Sus scrofa (Pig) TR34930_c3_g2_i1 0.000 0.328 23.836 0.474 0.943 0.000 Q95LU3 FBCD1_MACFA 6.00E-65 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR34997_c1_g1_i4 0.117 0.000 3.032 18.672 3.382 2.841 Q8MPM1 GELS2_LUMTE 8.00E-142 GO:0051693; GO:0005737; GO:0005856 actin filament capping; cytoplasm; cytoskeleton IPR007123; IPR007122; Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2) gelsolin Lumbricus terrestris (Common earthworm) TR35016_c2_g1_i4 0.463 84.746 2.533 0.320 0.962 118.886 P55066 NCAN_MOUSE 4.00E-17 GO:0005509; GO:0030246; GO:0007155; GO:0005576; GO:0005540; GO:0005886; GO:0051823 calcium ion binding; carbohydrate binding; cell adhesion; extracellular region; hyaluronic acid binding; plasma membrane; regulation of synapse structural plasticity IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR007110; IPR013783; IPR003599; IPR013106; IPR000538; IPR000436; Neurocan core protein (Chondroitin sulfate proteoglycan 3) Ncan Cspg3 Mus musculus (Mouse) TR35085_c0_g2_i2 7.047 0.810 5.353 27.614 5.387 0.000 P04088 INHBB_PIG 2.00E-14 GO:0032924; GO:0032869; GO:0009267; GO:0005576; GO:0045444; GO:0040007; GO:0046882; GO:0048178; GO:0046676; GO:0048471; GO:0046881; GO:0060279; GO:0042803; GO:0009612 activin receptor signaling pathway; cellular response to insulin stimulus; cellular response to starvation; extracellular region; fat cell differentiation; growth; negative regulation of follicle-stimulating hormone secretion; negative regulation of hepatocyte growth factor biosynthetic process; negative regulation of insulin secretion; perinuclear region of cytoplasm; positive regulation of follicle-stimulating hormone secretion; positive regulation of ovulation; protein homodimerization activity; response to mechanical stimulus IPR000381; IPR001839; IPR001111; IPR015615; IPR017948; Inhibin beta B chain (Activin beta-B chain) INHBB Sus scrofa (Pig) TR35146_c1_g1_i2 0.000 14.717 34.211 3.694 6.593 36.945 Q568K2 PP1RB_DANRE 2.00E-14 GO:0004864 protein phosphatase inhibitor activity IPR011107; Protein phosphatase 1 regulatory subunit 11 ppp1r11 zgc:110245 Danio rerio (Zebrafish) (Brachydanio rerio) TR35146_c1_g1_i5 24.398 19.782 0.000 4.183 4.760 15.473 Q568K2 PP1RB_DANRE 2.00E-14 GO:0004864 protein phosphatase inhibitor activity IPR011107; Protein phosphatase 1 regulatory subunit 11 ppp1r11 zgc:110245 Danio rerio (Zebrafish) (Brachydanio rerio) TR35203_c0_g1_i2 0.000 2.784 0.000 11.632 13.757 1.492 Q962X9 BUD31_BRABE 2.00E-91 GO:0005634 nucleus IPR018230; IPR001748; Protein BUD31 homolog (Protein G10 homolog) Branchiostoma belcheri (Amphioxus) TR35214_c2_g2_i8 17.862 0.126 4.321 0.000 0.493 0.000 Q91ZW7 C209E_MOUSE 6.00E-14 GO:0006897; GO:0016021; GO:0005537 endocytosis; integral to membrane; mannose binding IPR001304; IPR016186; IPR018378; IPR016187; CD209 antigen-like protein E (DC-SIGN-related protein 4) (DC-SIGNR4) (CD antigen CD209) Cd209e Mus musculus (Mouse) TR35225_c3_g2_i3 0.000 11.010 0.000 1.056 1.019 0.000 Q8NCC3 PAG15_HUMAN 8.00E-106 GO:0008374; GO:0047499; GO:0006672; GO:0005576; GO:0009062; GO:0004622; GO:0005764; GO:0005739; GO:0046470; GO:0005543 O-acyltransferase activity; calcium-independent phospholipase A2 activity; ceramide metabolic process; extracellular region; fatty acid catabolic process; lysophospholipase activity; lysosome; mitochondrion; phosphatidylcholine metabolic process; phospholipid binding IPR003386; Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) PLA2G15 LYPLA3 UNQ341/PRO540 Homo sapiens (Human) TR35351_c0_g1_i2 0.557 11.831 0.000 3.905 9.541 0.000 Q01196 RUNX1_HUMAN 2.00E-58 GO:0005524; GO:0003677; GO:0005604; GO:0048266; GO:0005509; GO:0007417; GO:0060216; GO:0035162; GO:0031069; GO:0071425; GO:0001701; GO:0001889; GO:0030099; GO:0002318; GO:0030853; GO:0005634; GO:0048935; GO:0045766; GO:0030854; GO:2000872; GO:0045944; GO:0045893; GO:0046982; GO:0042803; GO:0071336; GO:0009966; GO:0000975; GO:0003700; GO:0001501; GO:0008134; GO:0006351 Q13951; Q00534; Q15723; P16371; Q9H2X6; P17542; Q04724 "ATP binding; DNA binding; basement membrane; behavioral response to pain; calcium ion binding; central nervous system development; definitive hemopoiesis; embryonic hemopoiesis; hair follicle morphogenesis; hematopoietic stem cell proliferation; in utero embryonic development; liver development; myeloid cell differentiation; myeloid progenitor cell differentiation; negative regulation of granulocyte differentiation; nucleus; peripheral nervous system neuron development; positive regulation of angiogenesis; positive regulation of granulocyte differentiation; positive regulation of progesterone secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein heterodimerization activity; protein homodimerization activity; regulation of hair follicle cell proliferation; regulation of signal transduction; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; skeletal system development; transcription factor binding; transcription, DNA-dependent" IPR000040; IPR008967; IPR012346; IPR013524; IPR027384; IPR013711; IPR016554; Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) RUNX1 AML1 CBFA2 Homo sapiens (Human) TR35507_c1_g7_i2 0.359 0.466 0.668 7.573 0.895 0.000 Q60641 NR1H4_MOUSE 8.00E-26 GO:0000980; GO:0003705; GO:0001190; GO:0032052; GO:0008206; GO:0038181; GO:0071229; GO:1902122; GO:0048565; GO:0038185; GO:0004879; GO:0070858; GO:0000122; GO:0001080; GO:0005719; GO:0042277; GO:2001250; GO:0045944; GO:0006109; GO:0034255; GO:0009749; GO:0032496; GO:0046965; GO:0003707; GO:0004887; GO:0008270 RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; bile acid binding; bile acid metabolic process; bile acid receptor activity; cellular response to acid; chenodeoxycholic acid binding; digestive tract development; intracellular bile acid receptor signaling pathway; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; negative regulation of bile acid biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; nitrogen catabolite activation of transcription from RNA polymerase II promoter; nuclear euchromatin; peptide binding; positive regulation of ammonia assimilation cycle; positive regulation of transcription from RNA polymerase II promoter; regulation of carbohydrate metabolic process; regulation of urea metabolic process; response to glucose stimulus; response to lipopolysaccharide; retinoid X receptor binding; steroid hormone receptor activity; thyroid hormone receptor activity; zinc ion binding IPR008946; IPR000536; IPR001723; IPR001728; IPR001628; IPR013088; Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) Nr1h4 Bar Fxr Rip14 Mus musculus (Mouse) TR35507_c1_g7_i3 0.396 0.335 0.000 4.800 0.850 0.000 Q24143 HR96_DROME 2.00E-35 GO:0000977; GO:0042632; GO:0004879; GO:0005634; GO:0070873; GO:0042594; GO:0003707; GO:0070328; GO:0008270 RNA polymerase II regulatory region sequence-specific DNA binding; cholesterol homeostasis; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; regulation of glycogen metabolic process; response to starvation; steroid hormone receptor activity; triglyceride homeostasis; zinc ion binding IPR008946; IPR000536; IPR001628; IPR013088; Nuclear hormone receptor HR96 (dHR96) (Nuclear receptor subfamily 1 group J member 1) Hr96 NR1J1 CG11783 Drosophila melanogaster (Fruit fly) TR35685_c1_g2_i2 0.927 0.017 0.000 4.138 2.522 0.000 O54891 LEG6_MOUSE 7.00E-36 GO:0030246 carbohydrate binding IPR008985; IPR013320; IPR015533; IPR001079; Galectin-6 (Gal-6) Lgals6 Mus musculus (Mouse) TR35851_c4_g1_i1 0.185 357.624 1.806 39.285 94.927 128.693 Q00223 XP4_XENLA 1.00E-29 GO:0005576 extracellular region IPR000519; IPR017994; IPR017957; Putative gastrointestinal growth factor xP4 (TFF p4.1) p4 Xenopus laevis (African clawed frog) TR35907_c0_g1_i1 0.223 0.431 0.000 13.963 1.177 0.914 Q8TDY8 IGDC4_HUMAN 3.00E-08 GO:0016021; GO:0005886 integral to membrane; plasma membrane IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; Immunoglobulin superfamily DCC subclass member 4 (Neighbor of punc e11) (Protein DDM36) (hDDM36) IGDCC4 DDM36 KIAA1628 NOPE Homo sapiens (Human) TR35981_c0_g1_i4 29.115 0.194 0.000 0.000 0.045 0.039 Q5DC69 CH10_SCHJA 9.00E-39 GO:0005524; GO:0005759; GO:0006457 ATP binding; mitochondrial matrix; protein folding IPR020818; IPR018369; IPR011032; "10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10)" SJCHGC01960 SJCHGC09469 Schistosoma japonicum (Blood fluke) TR36037_c2_g1_i5 1.416 3.661 0.000 8.435 4.767 0.000 B1WAR9 GWL_XENTR 1.00E-08 GO:0005524; GO:0000086; GO:0051301; GO:0005813; GO:0032154; GO:0005737; GO:0007067; GO:0034048; GO:0005634; GO:0051721; GO:0004674; GO:0006974 ATP binding; G2/M transition of mitotic cell cycle; cell division; centrosome; cleavage furrow; cytoplasm; mitosis; negative regulation of protein phosphatase type 2A activity; nucleus; protein phosphatase 2A binding; protein serine/threonine kinase activity; response to DNA damage stimulus IPR000961; IPR011009; IPR000719; IPR008271; Serine/threonine-protein kinase greatwall (GW) (GWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) mastl gw gwl Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36061_c0_g1_i1 0.000 10.116 0.000 0.000 0.000 0.000 P56389 CDD_MOUSE 9.00E-54 GO:0004126; GO:0030308; GO:0045980; GO:0001882; GO:0042803; GO:0051289; GO:0008270 cytidine deaminase activity; negative regulation of cell growth; negative regulation of nucleotide metabolic process; nucleoside binding; protein homodimerization activity; protein homotetramerization; zinc ion binding IPR016192; IPR002125; IPR006262; IPR016193; Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) Cda Cdd Mus musculus (Mouse) TR36061_c0_g1_i3 10.278 51.002 1.009 0.000 0.000 0.000 Q7MK48 CDD_VIBVY 6.00E-09 GO:0004126; GO:0008270 cytidine deaminase activity; zinc ion binding IPR016192; IPR002125; IPR013171; IPR006263; IPR016193; IPR020797; Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) (CDA) cdd VV1962 Vibrio vulnificus (strain YJ016) TR36061_c0_g1_i7 0.601 0.006 51.008 39.287 48.017 15.710 Q09190 CDD_SCHPO 3.00E-29 GO:0004126; GO:0005829; GO:0005634; GO:0006206; GO:0008270 cytidine deaminase activity; cytosol; nucleus; pyrimidine nucleobase metabolic process; zinc ion binding IPR016192; IPR002125; IPR006262; IPR016193; Putative cytidine deaminase (CDA) (EC 3.5.4.5) (Cytidine aminohydrolase) pcd1 SPAC1556.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR36075_c1_g1_i2 0.060 0.116 0.000 1.863 0.269 0.000 Q5SSW2 PSME4_MOUSE 0 GO:0006281; GO:0005829; GO:0070577; GO:0007275; GO:0016607; GO:0005634; GO:0016504; GO:0010499; GO:0035093; GO:1990111 "DNA repair; cytosol; histone acetyl-lysine binding; multicellular organismal development; nuclear speck; nucleus; peptidase activator activity; proteasomal ubiquitin-independent protein catabolic process; spermatogenesis, exchange of chromosomal proteins; spermatoproteasome complex" IPR011989; IPR016024; IPR021843; Proteasome activator complex subunit 4 (Proteasome activator PA200) (Protein TEMO) Psme4 Kiaa0077 Mus musculus (Mouse) TR36164_c0_g1_i5 0.000 0.456 0.000 2.317 0.344 0.000 P13623 NFIX_MESAU 9.00E-102 GO:0003677; GO:0006260; GO:0005634; GO:0003700; GO:0006351 "DNA binding; DNA replication; nucleus; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR000647; IPR020604; IPR019739; IPR019548; IPR003619; Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) NFIX Mesocricetus auratus (Golden hamster) TR36168_c4_g2_i5 0.000 22.237 1.353 7.499 0.151 3.586 Q27294 CAZ_DROME 5.00E-27 GO:0008344; GO:0071013; GO:0048749; GO:0008345; GO:0003729; GO:0000398; GO:0005654; GO:0000166; GO:0008270 "adult locomotory behavior; catalytic step 2 spliceosome; compound eye development; larval locomotory behavior; mRNA binding; mRNA splicing, via spliceosome; nucleoplasm; nucleotide binding; zinc ion binding" IPR012677; IPR000504; IPR001876; RNA-binding protein cabeza (P19) (Sarcoma-associated RNA-binding fly homolog) caz SARFH CG3606 Drosophila melanogaster (Fruit fly) TR36169_c7_g2_i3 1.884 0.651 0.000 0.000 0.079 0.234 P24733 MYS_AEQIR 0 GO:0005524; GO:0003774; GO:0030016; GO:0032982 ATP binding; motor activity; myofibril; myosin filament IPR000048; IPR027401; IPR015650; IPR001609; IPR004009; IPR002928; IPR027417; "Myosin heavy chain, striated muscle" Argopecten irradians (Bay scallop) (Aequipecten irradians) TR36207_c0_g2_i1 0.000 1.241 1.008 5.330 1.410 1.915 B1WAZ6 PA24A_XENTR 1.00E-130 GO:0016023; GO:0004622; GO:0046872; GO:0004623; GO:0009395 cytoplasmic membrane-bounded vesicle; lysophospholipase activity; metal ion binding; phospholipase A2 activity; phospholipid catabolic process IPR016035; IPR000008; IPR002642; Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] pla2g4a cpla2 pla2g4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR36226_c0_g2_i6 1.477 1.235 0.000 4.776 2.159 0.187 Q921F2 TADBP_MOUSE 3.00E-115 GO:0070935; GO:0001205; GO:0008380; GO:0003690; GO:0003730; GO:0006397; GO:0043922; GO:0000166; GO:0005634 3'-UTR-mediated mRNA stabilization; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA splicing; double-stranded DNA binding; mRNA 3'-UTR binding; mRNA processing; negative regulation by host of viral transcription; nucleotide binding; nucleus IPR012677; IPR000504; TAR DNA-binding protein 43 (TDP-43) Tardbp Tdp43 Mus musculus (Mouse) TR36235_c1_g2_i7 1.084 0.194 0.000 2.684 0.777 0.156 P49103 RAB2A_MAIZE 6.00E-42 GO:0005525; GO:0033116; GO:0015031; GO:0007264 GTP binding; endoplasmic reticulum-Golgi intermediate compartment membrane; protein transport; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-2-A RAB2A Zea mays (Maize) TR36275_c0_g1_i1 0.000 12.708 0.000 0.000 0.562 0.000 P07306 ASGR1_HUMAN 5.00E-17 GO:0004873; GO:0030246; GO:0031668; GO:0005576; GO:0005887; GO:0046872 Q96G23 asialoglycoprotein receptor activity; carbohydrate binding; cellular response to extracellular stimulus; extracellular region; integral to plasma membrane; metal ion binding IPR001304; IPR016186; IPR018378; IPR016187; IPR005640; Asialoglycoprotein receptor 1 (ASGP-R 1) (ASGPR 1) (C-type lectin domain family 4 member H1) (Hepatic lectin H1) (HL-1) ASGR1 CLEC4H1 Homo sapiens (Human) TR36275_c0_g1_i3 0.036 0.060 23.227 0.000 0.081 0.000 Q28062 PGCB_BOVIN 2.00E-20 GO:0030246; GO:0007155; GO:0005540; GO:0005578 carbohydrate binding; cell adhesion; hyaluronic acid binding; proteinaceous extracellular matrix IPR001304; IPR016186; IPR018378; IPR016187; IPR000742; IPR013032; IPR007110; IPR013783; IPR003006; IPR013106; IPR003596; IPR000538; IPR000436; Brevican core protein BCAN Bos taurus (Bovine) TR36339_c4_g1_i1 0.043 0.066 0.000 2.642 5.636 0.029 Q752Y3 ALO_ASHGO 6.00E-18 GO:0003885; GO:0008762; GO:0034599; GO:0070485; GO:0050660; GO:0031307 "D-arabinono-1,4-lactone oxidase activity; UDP-N-acetylmuramate dehydrogenase activity; cellular response to oxidative stress; dehydro-D-arabinono-1,4-lactone biosynthetic process; flavin adenine dinucleotide binding; integral to mitochondrial outer membrane" IPR007173; IPR016169; IPR016166; IPR016167; IPR010031; IPR023595; IPR006094; IPR006093; "Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2." "D-arabinono-1,4-lactone oxidase (ALO) (EC 1.1.3.37) (L-galactono-gamma-lactone oxidase)" ALO1 AFR440C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR36339_c4_g1_i3 0.056 0.000 0.000 4.090 0.047 0.115 Q752Y3 ALO_ASHGO 9.00E-18 GO:0003885; GO:0008762; GO:0034599; GO:0070485; GO:0050660; GO:0031307 "D-arabinono-1,4-lactone oxidase activity; UDP-N-acetylmuramate dehydrogenase activity; cellular response to oxidative stress; dehydro-D-arabinono-1,4-lactone biosynthetic process; flavin adenine dinucleotide binding; integral to mitochondrial outer membrane" IPR007173; IPR016169; IPR016166; IPR016167; IPR010031; IPR023595; IPR006094; IPR006093; "Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2." "D-arabinono-1,4-lactone oxidase (ALO) (EC 1.1.3.37) (L-galactono-gamma-lactone oxidase)" ALO1 AFR440C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) TR36400_c1_g2_i3 558.750 5.527 0.317 0.125 0.174 0.000 Q3T149 HSPB1_BOVIN 3.00E-13 GO:0005737; GO:0005634; GO:0006950; GO:0005819 cytoplasm; nucleus; response to stress; spindle IPR002068; IPR001436; IPR008978; Heat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) HSPB1 HSP27 Bos taurus (Bovine) TR36423_c0_g1_i1 3.742 5.922 0.000 22.612 10.864 4.526 P07688 CATB_BOVIN 2.00E-120 GO:0097067; GO:0004197; GO:0005615; GO:0005764; GO:0042470; GO:0005739; GO:0048471; GO:0006508; GO:0050790 cellular response to thyroid hormone stimulus; cysteine-type endopeptidase activity; extracellular space; lysosome; melanosome; mitochondrion; perinuclear region of cytoplasm; proteolysis; regulation of catalytic activity IPR025661; IPR000169; IPR025660; IPR013128; IPR000668; IPR012599; Cathepsin B (EC 3.4.22.1) (BCSB) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] CTSB Bos taurus (Bovine) TR36424_c5_g1_i7 0.092 0.060 141.146 0.460 1.431 0.157 P37802 TAGL2_HUMAN 1.00E-09 GO:0007517 P60709 muscle organ development IPR000557; IPR001715; IPR003096; IPR001061; Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog) TAGLN2 KIAA0120 CDABP0035 Homo sapiens (Human) TR36475_c0_g1_i2 1.527 2.359 1.765 4.553 4.711 0.000 Q5R664 COPB2_PONAB 4.00E-72 GO:0030663; GO:0006886; GO:0030117; GO:0005198; GO:0016192 COPI-coated vesicle membrane; intracellular protein transport; membrane coat; structural molecule activity; vesicle-mediated transport IPR006692; IPR016453; IPR020472; IPR015943; IPR001680; IPR017986; Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) COPB2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR36497_c0_g1_i3 0.477 0.000 4.090 0.000 0.324 0.000 Q02723 RKIN1_SECCE 1.00E-21 GO:0005524; GO:0005975; GO:0004674 ATP binding; carbohydrate metabolic process; protein serine/threonine kinase activity IPR028375; IPR001772; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; IPR015940; Carbon catabolite-derepressing protein kinase (EC 2.7.11.1) RKIN1 Secale cereale (Rye) TR36497_c0_g1_i4 6.132 0.562 0.000 0.000 0.000 1.503 Q8C0N0 SMKZ_MOUSE 1.00E-22 GO:0005524; GO:0004674 ATP binding; protein serine/threonine kinase activity IPR011009; IPR000719; IPR002290; IPR008271; Sperm motility kinase Z (EC 2.7.11.1) Gm4922 Mus musculus (Mouse) TR36503_c1_g2_i6 934.147 7.865 2.184 0.165 1.188 6.411 P86179 CSL3_ONCKE 2.00E-10 GO:0030246 carbohydrate binding IPR000922; L-rhamnose-binding lectin CSL3 Oncorhynchus keta (Chum salmon) (Salmo keta) TR36539_c0_g4_i4 0.630 2.768 0.907 10.131 8.487 0.000 Q8VIJ5 NCOAT_RAT 7.00E-168 GO:0006044; GO:0007568; GO:0004563; GO:0005737; GO:0046060; GO:0004402; GO:0070265; GO:0010616; GO:0060051; GO:0005634; GO:0051054; GO:0010524; GO:0031343; GO:0046326; GO:0060124; GO:0032024; GO:0051901; GO:0043243; GO:0045862; GO:0006612; GO:0048545 N-acetylglucosamine metabolic process; aging; beta-N-acetylhexosaminidase activity; cytoplasm; dATP metabolic process; histone acetyltransferase activity; necrotic cell death; negative regulation of cardiac muscle adaptation; negative regulation of protein glycosylation; nucleus; positive regulation of DNA metabolic process; positive regulation of calcium ion transport into cytosol; positive regulation of cell killing; positive regulation of glucose import; positive regulation of growth hormone secretion; positive regulation of insulin secretion; positive regulation of mitochondrial depolarization; positive regulation of protein complex disassembly; positive regulation of proteolysis; protein targeting to membrane; response to steroid hormone stimulus IPR016181; IPR011496; IPR017853; Bifunctional protein NCOAT (Meningioma-expressed antigen 5) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) [Includes: Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (HAT) (EC 2.3.1.48)] Mgea5 Hexc Mea5 Rattus norvegicus (Rat) TR36733_c3_g1_i3 2.590 0.914 1.660 8.007 1.052 0.000 Q6YKA8 DRK_DROSI 1.00E-77 GO:0005070; GO:0005886; GO:0004871 SH3/SH2 adaptor activity; plasma membrane; signal transducer activity IPR000108; IPR000980; IPR001452; Protein E(sev)2B (Downstream of receptor kinase) (Protein enhancer of sevenless 2B) (SH2-SH3 adapter protein drk) drk E(sev)2B Drosophila simulans (Fruit fly) TR36769_c2_g1_i4 0.923 0.638 0.000 4.775 0.706 0.000 P49755 TMEDA_HUMAN 5.00E-86 GO:0048205; GO:0030137; GO:0048208; GO:0007030; GO:0034205; GO:0035459; GO:0005801; GO:0005783; GO:0005789; GO:0005793; GO:0033116; GO:0070765; GO:0016021; GO:0006886; GO:0001822; GO:0042470; GO:0051259; GO:0045055; GO:0001101; GO:0043279; GO:0006890; GO:0030140; GO:0030658; GO:0042589 Q92542; P49768; Q9NZ42; P17706-1; Q15363 "COPI coating of Golgi vesicle; COPI-coated vesicle; COPII vesicle coating; Golgi organization; beta-amyloid formation; cargo loading into vesicle; cis-Golgi network; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; gamma-secretase complex; integral to membrane; intracellular protein transport; kidney development; melanosome; protein oligomerization; regulated secretory pathway; response to acid; response to alkaloid; retrograde vesicle-mediated transport, Golgi to ER; trans-Golgi network transport vesicle; transport vesicle membrane; zymogen granule membrane" IPR009038; Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (S31III125) (S31I125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta) TMED10 TMP21 Homo sapiens (Human) TR36856_c3_g2_i3 1.657 0.029 0.000 0.961 15.764 3.342 A6NMZ7 CO6A6_HUMAN 3.00E-31 GO:0007155; GO:0005581; GO:0030574; GO:0031012; GO:0022617; GO:0005576 cell adhesion; collagen; collagen catabolic process; extracellular matrix; extracellular matrix disassembly; extracellular region IPR008160; IPR002035; Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) TR36983_c2_g1_i1 0.683 1.023 0.000 6.091 2.258 0.247 Q0III3 DC1I2_BOVIN 0 GO:0005868; GO:0005874; GO:0007018; GO:0003774; GO:0006810; GO:0031982 cytoplasmic dynein complex; microtubule; microtubule-based movement; motor activity; transport; vesicle IPR025956; IPR015943; IPR001680; IPR017986; "Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)" DYNC1I2 Bos taurus (Bovine) TR36983_c2_g1_i4 0.794 0.867 1.640 10.349 2.651 0.000 Q0III3 DC1I2_BOVIN 0 GO:0005868; GO:0005874; GO:0007018; GO:0003774; GO:0006810; GO:0031982 cytoplasmic dynein complex; microtubule; microtubule-based movement; motor activity; transport; vesicle IPR025956; IPR015943; IPR001680; IPR017986; "Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)" DYNC1I2 Bos taurus (Bovine) TR37016_c2_g1_i1 51.213 48.160 37.037 0.042 0.712 7.959 P55918 MFAP4_BOVIN 5.00E-69 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR014716; IPR014715; IPR002181; Microfibril-associated glycoprotein 4 (36 kDa microfibril-associated glycoprotein) (36 kDa MAP) MFAP4 Bos taurus (Bovine) TR37016_c2_g1_i6 0.000 0.842 0.567 3.957 8.745 22.361 Q8N539 FBCD1_HUMAN 5.00E-71 GO:0008061; GO:0016021; GO:0016020; GO:0046872 chitin binding; integral to membrane; membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) TR37028_c2_g1_i6 1.772 0.150 0.000 4.031 2.286 0.012 Q1JPZ3 SRC_DANRE 0 GO:0005524; GO:0007155; GO:0007049; GO:0005856; GO:0005743; GO:0004715; GO:0005634; GO:0018108; GO:0005886 ATP binding; cell adhesion; cell cycle; cytoskeleton; mitochondrial inner membrane; non-membrane spanning protein tyrosine kinase activity; nucleus; peptidyl-tyrosine phosphorylation; plasma membrane IPR011009; IPR000719; IPR017441; IPR001245; IPR000980; IPR001452; IPR008266; IPR020635; Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) src Danio rerio (Zebrafish) (Brachydanio rerio) TR37089_c0_g1_i2 0.000 0.000 2.782 11.327 6.633 1.098 Q9VSH3 BI1_DROME 7.00E-33 GO:0006915; GO:0009267; GO:0005789; GO:0016021; GO:0043066; GO:0010507; GO:0060548; GO:0060702; GO:0006986; GO:0035071 apoptotic process; cellular response to starvation; endoplasmic reticulum membrane; integral to membrane; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of cell death; negative regulation of endoribonuclease activity; response to unfolded protein; salivary gland cell autophagic cell death IPR006213; IPR006214; Probable Bax inhibitor 1 (BI-1) CG7188 Drosophila melanogaster (Fruit fly) TR37089_c0_g1_i4 4.052 5.247 0.323 0.000 0.022 0.000 Q9IA79 BI1_PAROL 1.00E-75 GO:0006915; GO:0005789; GO:0016021; GO:0043066; GO:0006986 apoptotic process; endoplasmic reticulum membrane; integral to membrane; negative regulation of apoptotic process; response to unfolded protein IPR006213; IPR006214; Probable Bax inhibitor 1 (BI-1) (Testis-enhanced gene transcript protein homolog) (Transmembrane BAX inhibitor motif-containing protein 6) tmbim6 tegt Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) TR37251_c0_g1_i1 5.685 2.267 6.537 71.818 13.121 0.017 Q3MHW9 NB5R1_BOVIN 2.00E-132 GO:0004128; GO:0016021; GO:0016126 "cytochrome-b5 reductase activity, acting on NAD(P)H; integral to membrane; sterol biosynthetic process" IPR017927; IPR001709; IPR001834; IPR008333; IPR001433; IPR017938; NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) CYB5R1 Bos taurus (Bovine) TR37342_c2_g2_i2 2.705 20.087 6.815 24.230 9.696 0.000 A0MSJ1 CRA1B_DANRE 4.00E-07 GO:0030282; GO:0005581; GO:0005201; GO:0046872; GO:0048570; GO:0001501 bone mineralization; collagen; extracellular matrix structural constituent; metal ion binding; notochord morphogenesis; skeletal system development IPR008160; IPR008985; IPR013320; IPR000885; IPR001791; Collagen alpha-1(XXVII) chain B col27a1b col27a1 Danio rerio (Zebrafish) (Brachydanio rerio) TR37377_c3_g1_i1 0.000 0.000 0.000 3.520 0.020 0.000 Q14790 CASP8_HUMAN 4.00E-25 GO:0031265; GO:0030690; GO:0035666; GO:0006919; GO:0001525; GO:0044297; GO:0006921; GO:0071260; GO:0005813; GO:0097153; GO:0005829; GO:0031264; GO:0097191; GO:0007507; GO:0045087; GO:0097193; GO:0030225; GO:0045121; GO:0005741; GO:0019048; GO:0043124; GO:0001841; GO:0043005; GO:0070423; GO:0005634; GO:0043123; GO:0045651; GO:1900740; GO:0045862; GO:0051291; GO:0051603; GO:2001239; GO:0046677; GO:0032025; GO:0009409; GO:0032355; GO:0045471; GO:0032496; GO:0034612; GO:0097342; GO:0034138; GO:0034142 P51572; Q92851; Q9UKL3; O15519-1; Q13618; Q13158; P25445; P48023; Q13418; Q9UDY8; O60936; P29350; Q13546; O00220 CD95 death-inducing signaling complex; Noc1p-Noc2p complex; TRIF-dependent toll-like receptor signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; cell body; cellular component disassembly involved in execution phase of apoptosis; cellular response to mechanical stimulus; centrosome; cysteine-type endopeptidase activity involved in apoptotic process; cytosol; death-inducing signaling complex; extrinsic apoptotic signaling pathway; heart development; innate immune response; intrinsic apoptotic signaling pathway; macrophage differentiation; membrane raft; mitochondrial outer membrane; modulation by virus of host morphology or physiology; negative regulation of I-kappaB kinase/NF-kappaB cascade; neural tube formation; neuron projection; nucleotide-binding oligomerization domain containing signaling pathway; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macrophage differentiation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of proteolysis; protein heterooligomerization; proteolysis involved in cellular protein catabolic process; regulation of extrinsic apoptotic signaling pathway in absence of ligand; response to antibiotic; response to cobalt ion; response to cold; response to estradiol stimulus; response to ethanol; response to lipopolysaccharide; response to tumor necrosis factor; ripoptosome; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway IPR011029; IPR001875; IPR011600; IPR001309; IPR016129; IPR002138; IPR015917; Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) TR37384_c6_g3_i2 0.000 0.000 0.000 31.982 3.551 0.000 O35608 ANGP2_MOUSE 4.00E-40 GO:0048014; GO:0001525; GO:0001974; GO:0042995; GO:0071363; GO:0007492; GO:0005615; GO:0007281; GO:0072012; GO:0030097; GO:0060135; GO:0046872; GO:0016525; GO:0043537; GO:0010812; GO:0050928; GO:0005634; GO:0031100; GO:0005886; GO:0045766; GO:0014823; GO:0009749; GO:0001666; GO:0009612; GO:0014070; GO:0009314; GO:0005172 Tie signaling pathway; angiogenesis; blood vessel remodeling; cell projection; cellular response to growth factor stimulus; endoderm development; extracellular space; germ cell development; glomerulus vasculature development; hemopoiesis; maternal process involved in female pregnancy; metal ion binding; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell-substrate adhesion; negative regulation of positive chemotaxis; nucleus; organ regeneration; plasma membrane; positive regulation of angiogenesis; response to activity; response to glucose stimulus; response to hypoxia; response to mechanical stimulus; response to organic cyclic compound; response to radiation; vascular endothelial growth factor receptor binding IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-2 (ANG-2) Angpt2 Agpt2 Mus musculus (Mouse) TR37436_c0_g1_i1 44.432 0.000 0.000 0.000 0.000 0.000 Q7NJF7 GPMA2_GLOVI 4.00E-46 GO:0046538; GO:0006096 "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; glycolysis" IPR013078; IPR001345; IPR005952; Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2 (BPG-dependent PGAM 2) (PGAM 2) (Phosphoglyceromutase 2) (dPGM 2) (EC 5.4.2.11)" gpmA2 gll1875 Gloeobacter violaceus (strain PCC 7421) TR37436_c0_g1_i3 10.679 1.345 0.000 0.318 0.086 0.000 Q54NE6 PGAM_DICDI 9.00E-119 GO:0004083; GO:0004082; GO:0005829; GO:0006094; GO:0006096; GO:0045335; GO:0004619 bisphosphoglycerate 2-phosphatase activity; bisphosphoglycerate mutase activity; cytosol; gluconeogenesis; glycolysis; phagocytic vesicle; phosphoglycerate mutase activity IPR013078; IPR001345; IPR005952; Probable phosphoglycerate mutase (EC 3.1.3.13) (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM) (dPGM) gpmA pgam DDB_G0285311 Dictyostelium discoideum (Slime mold) TR37480_c2_g1_i11 0.244 2.256 0.000 4.179 4.836 0.751 A4FUZ5 SERC3_BOVIN 2.00E-125 GO:0000139; GO:0016021; GO:0005886 Golgi membrane; integral to membrane; plasma membrane IPR005016; Serine incorporator 3 SERINC3 Bos taurus (Bovine) TR37480_c2_g1_i2 0.460 4.510 0.000 5.129 6.413 0.371 A4FUZ5 SERC3_BOVIN 9.00E-126 GO:0000139; GO:0016021; GO:0005886 Golgi membrane; integral to membrane; plasma membrane IPR005016; Serine incorporator 3 SERINC3 Bos taurus (Bovine) TR37480_c2_g1_i4 2.012 4.213 0.000 4.664 7.023 0.186 Q96SA4 SERC2_HUMAN 5.00E-98 GO:0016021; GO:0006658; GO:0051347 integral to membrane; phosphatidylserine metabolic process; positive regulation of transferase activity IPR005016; Serine incorporator 2 (Tumor differentially expressed protein 2-like) SERINC2 TDE2L FKSG84 UNQ263/PRO300 Homo sapiens (Human) TR37480_c2_g1_i5 1.281 2.014 4.370 7.303 8.504 0.000 A4FUZ5 SERC3_BOVIN 8.00E-126 GO:0000139; GO:0016021; GO:0005886 Golgi membrane; integral to membrane; plasma membrane IPR005016; Serine incorporator 3 SERINC3 Bos taurus (Bovine) TR37511_c0_g1_i5 0.000 0.000 0.000 6.115 10.451 0.000 A7N2Q0 BETB_VIBHB 3.00E-163 GO:0008802; GO:0019285; GO:0046872 betaine-aldehyde dehydrogenase activity; glycine betaine biosynthetic process from choline; metal ion binding IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR011264; Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. NAD/NADP-dependent betaine aldehyde dehydrogenase (BADH) (EC 1.2.1.8) betB VIBHAR_06180 Vibrio campbellii (strain ATCC BAA-1116 / BB120) TR37528_c4_g1_i3 0.664 1.056 0.000 8.135 2.564 1.050 Q64709 HLF_RAT 8.00E-54 GO:0005634; GO:0048511; GO:0043565; GO:0003700; GO:0006351 "nucleus; rhythmic process; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent" IPR004827; Hepatic leukemia factor Hlf Rattus norvegicus (Rat) TR37552_c1_g1_i1 20.201 2.133 0.000 0.000 0.153 0.000 Q96I24 FUBP3_HUMAN 8.00E-68 GO:0003677; GO:0003723; GO:0005737; GO:0005634; GO:0045893; GO:0006351 "DNA binding; RNA binding; cytoplasm; nucleus; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR004087; IPR004088; Far upstream element-binding protein 3 (FUSE-binding protein 3) FUBP3 FBP3 Homo sapiens (Human) TR37637_c0_g1_i2 64.651 84.437 65.597 0.056 0.931 194.059 Q02217 YE034_YEAST 1.00E-13 GO:0016021 integral to membrane Putative uncharacterized protein YEL034C-A YEL034C-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR37662_c0_g1_i2 0.667 1.016 1.085 7.335 1.572 0.000 Q9W6C5 PDC6I_XENLA 1.00E-174 GO:0015031 protein transport IPR025304; IPR004328; Programmed cell death 6-interacting protein (Signal transduction protein Xp95) pdcd6ip Xenopus laevis (African clawed frog) TR37707_c0_g2_i10 0.000 0.076 0.350 3.284 0.605 0.000 Q6PFY9 CC14B_MOUSE 2.00E-161 GO:0006281; GO:0031572; GO:0051488; GO:0031965; GO:0005730; GO:0005654; GO:0006470; GO:0004722; GO:0004725; GO:0008138 DNA repair; G2 DNA damage checkpoint; activation of anaphase-promoting complex activity; nuclear membrane; nucleolus; nucleoplasm; protein dephosphorylation; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity IPR000340; IPR020422; IPR026068; IPR000387; IPR016130; Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B) Cdc14b Mus musculus (Mouse) TR37707_c0_g2_i8 0.000 0.000 0.000 2.186 0.224 0.000 Q9UNH5 CC14A_HUMAN 0 GO:0007049; GO:0051301; GO:0008283; GO:0005813; GO:0005737; GO:0005634; GO:0035335; GO:0004721; GO:0004725; GO:0008138; GO:0005819 cell cycle; cell division; cell proliferation; centrosome; cytoplasm; nucleus; peptidyl-tyrosine dephosphorylation; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; spindle IPR000340; IPR020422; IPR026068; IPR000387; IPR016130; Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) CDC14A Homo sapiens (Human) TR37735_c4_g2_i10 0.000 0.000 0.000 1.485 0.114 0.000 Q5GN48 DMD_PIG 6.00E-31 GO:0005509; GO:0030054; GO:0005737; GO:0005856; GO:0045211; GO:0042383; GO:0008270 calcium ion binding; cell junction; cytoplasm; cytoskeleton; postsynaptic membrane; sarcolemma; zinc ion binding IPR001589; IPR001715; IPR016344; IPR011992; IPR015153; IPR015154; IPR018159; IPR002017; IPR001202; IPR000433; Dystrophin DMD Sus scrofa (Pig) TR37735_c4_g2_i4 0.000 0.000 0.000 1.156 0.075 0.000 Q9UPN3 MACF1_HUMAN 0 GO:0016887; GO:0005794; GO:0043001; GO:0016055; GO:0015629; GO:0051015; GO:0005509; GO:0007050; GO:0006928; GO:0007163; GO:0001707; GO:0005874; GO:0008017; GO:0030177; GO:0006620; GO:0010632; GO:0051893; GO:0032886; GO:0032587; GO:0042060 Q9NRI5 ATPase activity; Golgi apparatus; Golgi to plasma membrane protein transport; Wnt receptor signaling pathway; actin cytoskeleton; actin filament binding; calcium ion binding; cell cycle arrest; cellular component movement; establishment or maintenance of cell polarity; mesoderm formation; microtubule; microtubule binding; positive regulation of Wnt receptor signaling pathway; posttranslational protein targeting to membrane; regulation of epithelial cell migration; regulation of focal adhesion assembly; regulation of microtubule-based process; ruffle membrane; wound healing IPR001589; IPR001715; IPR011992; IPR018247; IPR002048; IPR003108; IPR001101; IPR018159; IPR002017; "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)" MACF1 ABP620 ACF7 KIAA0465 KIAA1251 Homo sapiens (Human) TR37744_c1_g2_i1 1.221 0.518 2.021 5.062 1.505 0.000 B2GUZ1 UBP4_RAT 0 GO:0005737; GO:0046872; GO:0031397; GO:0005634; GO:0016579; GO:0034394; GO:0031647; GO:0004221; GO:0006511; GO:0004843 cytoplasm; metal ion binding; negative regulation of protein ubiquitination; nucleus; protein deubiquitination; protein localization to cell surface; regulation of protein stability; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; ubiquitin-specific protease activity IPR006615; IPR018200; IPR001394; IPR028135; IPR028134; Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) Usp4 Rattus norvegicus (Rat) TR37999_c2_g1_i1 0.805 0.696 0.000 19.255 3.902 0.078 Q96RW7 HMCN1_HUMAN 7.00E-13 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896; GO:0007601 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus; visual perception IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR000884; IPR002035; Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) TR38098_c0_g2_i3 9.409 20.147 0.000 23.643 8.753 4.489 Q8R0Z6 ANGL6_MOUSE 3.00E-29 GO:0001525; GO:0030154; GO:0005576; GO:0030141 angiogenesis; cell differentiation; extracellular region; secretory granule IPR014716; IPR014715; IPR002181; IPR020837; Angiopoietin-related protein 6 (Angiopoietin-like protein 6) (Angiopoietin-related growth factor) Angptl6 Agf Mus musculus (Mouse) TR38209_c3_g1_i5 16.705 0.000 0.581 3.055 8.124 10.596 Q4R4S4 ARL8B_MACFA 4.00E-06 GO:0005525; GO:0051301; GO:0007059; GO:0031902; GO:0005765; GO:0007067; GO:0007264; GO:0005819 GTP binding; cell division; chromosome segregation; late endosome membrane; lysosomal membrane; mitosis; small GTPase mediated signal transduction; spindle IPR027417; IPR005225; IPR024156; IPR006689; ADP-ribosylation factor-like protein 8B ARL8B QflA-10573 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TR38239_c0_g1_i4 0.518 0.125 0.493 17.919 4.437 0.000 O00087 DLDH_SCHPO 0 GO:0006103; GO:0000082; GO:0006564; GO:0006086; GO:0045454; GO:0004148; GO:0015036; GO:0050660; GO:0005960; GO:0019464; GO:0006550; GO:0006552; GO:0042645; GO:0009353; GO:0005967; GO:0004739; GO:0006574 2-oxoglutarate metabolic process; G1/S transition of mitotic cell cycle; L-serine biosynthetic process; acetyl-CoA biosynthetic process from pyruvate; cell redox homeostasis; dihydrolipoyl dehydrogenase activity; disulfide oxidoreductase activity; flavin adenine dinucleotide binding; glycine cleavage complex; glycine decarboxylation via glycine cleavage system; isoleucine catabolic process; leucine catabolic process; mitochondrial nucleoid; mitochondrial oxoglutarate dehydrogenase complex; mitochondrial pyruvate dehydrogenase complex; pyruvate dehydrogenase (acetyl-transferring) activity; valine catabolic process IPR016156; IPR013027; IPR006258; IPR004099; IPR023753; IPR012999; IPR001327; "Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (DLDH)" dld1 SPAC1002.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR38256_c1_g1_i4 10.502 0.438 0.006 0.708 1.098 0.046 Q8R066 C1QT4_MOUSE 1.00E-07 GO:0005615 extracellular space IPR001073; IPR008983; Complement C1q tumor necrosis factor-related protein 4 C1qtnf4 Mus musculus (Mouse) TR38339_c8_g3_i1 0.000 0.001 0.000 1.044 0.043 0.000 Q4U2R1 HERC2_MOUSE 0 GO:0006281; GO:0032183; GO:0005814; GO:0020037; GO:0005743; GO:0005634; GO:0042787; GO:0007283; GO:0004842; GO:0008270 DNA repair; SUMO binding; centriole; heme binding; mitochondrial inner membrane; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; spermatogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR004939; IPR006624; IPR021097; IPR001199; IPR008979; IPR000569; IPR010606; IPR009091; IPR000408; IPR014722; IPR000433; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 2) Herc2 Jdf2 Kiaa0393 Rjs Mus musculus (Mouse) TR38353_c3_g1_i2 33.631 17.988 22.384 0.051 2.710 5.507 Q9U8W8 TL5A_TACTR 3.00E-50 GO:0030246; GO:0016337; GO:0005576; GO:0046872 carbohydrate binding; cell-cell adhesion; extracellular region; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Techylectin-5A Tachypleus tridentatus (Japanese horseshoe crab) TR38353_c3_g1_i9 21.640 0.158 0.504 0.000 0.000 0.000 Q15485 FCN2_HUMAN 1.00E-58 GO:0003823; GO:0005509; GO:0030246; GO:0005581; GO:0001867; GO:0005576; GO:0008228 Q07954 "antigen binding; calcium ion binding; carbohydrate binding; collagen; complement activation, lectin pathway; extracellular region; opsonization" IPR008160; IPR014716; IPR014715; IPR002181; IPR020837; Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35) FCN2 FCNL Homo sapiens (Human) TR38357_c0_g1_i8 0.000 7.409 5.085 0.000 0.198 5.811 Q0ULD0 NACB_PHANO 5.00E-35 GO:0005737; GO:0005634; GO:0015031; GO:0006355; GO:0006351 "cytoplasm; nucleus; protein transport; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR002715; Nascent polypeptide-associated complex subunit beta (NAC-beta) (Beta-NAC) EGD1 SNOG_07434 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) TR38451_c0_g1_i4 0.000 0.146 0.000 3.957 2.480 0.000 Q8C8H8 KY_MOUSE 4.00E-46 GO:0030018; GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0006508 Z disc; cytoskeleton; muscle organ development; neuromuscular junction development; peptidase activity; proteolysis IPR002931; Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) TR38523_c2_g2_i1 0.000 0.000 0.000 1.372 0.059 0.000 Q9EQ60 CAC1H_RAT 0 GO:0032342; GO:0070509; GO:0034651; GO:0005737; GO:0030425; GO:0008332; GO:0046872; GO:0005634; GO:0043204; GO:0019233; GO:0005891 aldosterone biosynthetic process; calcium ion import; cortisol biosynthetic process; cytoplasm; dendrite; low voltage-gated calcium channel activity; metal ion binding; nucleus; perikaryon; sensory perception of pain; voltage-gated calcium channel complex IPR027359; IPR005821; IPR005445; Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage-gated calcium channel subunit alpha Cav3.2) Cacna1h Rattus norvegicus (Rat) TR38523_c2_g2_i5 0.000 0.000 0.000 1.272 0.000 0.000 O95180 CAC1H_HUMAN 0 GO:0032342; GO:0007411; GO:0070509; GO:0005901; GO:0032870; GO:0035865; GO:0034651; GO:0008332; GO:0046872; GO:0006936; GO:0007517; GO:0007520; GO:2000344; GO:0008016; GO:0042391; GO:0042383; GO:0005891 aldosterone biosynthetic process; axon guidance; calcium ion import; caveola; cellular response to hormone stimulus; cellular response to potassium ion; cortisol biosynthetic process; low voltage-gated calcium channel activity; metal ion binding; muscle contraction; muscle organ development; myoblast fusion; positive regulation of acrosome reaction; regulation of heart contraction; regulation of membrane potential; sarcolemma; voltage-gated calcium channel complex IPR027359; IPR005821; IPR005445; Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) CACNA1H Homo sapiens (Human) TR38523_c2_g2_i7 0.000 0.000 0.000 1.168 0.170 0.000 O95180 CAC1H_HUMAN 0 GO:0032342; GO:0007411; GO:0070509; GO:0005901; GO:0032870; GO:0035865; GO:0034651; GO:0008332; GO:0046872; GO:0006936; GO:0007517; GO:0007520; GO:2000344; GO:0008016; GO:0042391; GO:0042383; GO:0005891 aldosterone biosynthetic process; axon guidance; calcium ion import; caveola; cellular response to hormone stimulus; cellular response to potassium ion; cortisol biosynthetic process; low voltage-gated calcium channel activity; metal ion binding; muscle contraction; muscle organ development; myoblast fusion; positive regulation of acrosome reaction; regulation of heart contraction; regulation of membrane potential; sarcolemma; voltage-gated calcium channel complex IPR027359; IPR005821; IPR005445; Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) CACNA1H Homo sapiens (Human) TR38555_c2_g3_i2 0.196 0.036 0.000 4.702 0.221 0.000 Q9UBX3 DIC_HUMAN 5.00E-52 GO:0015297; GO:0034641; GO:0005310; GO:0006094; GO:0016021; GO:0015140; GO:0005743; GO:0006839; GO:0005634; GO:0015114; GO:0015141; GO:0015116; GO:0008272; GO:0070221; GO:0000098; GO:0015117; GO:0015709 Q99750 "antiporter activity; cellular nitrogen compound metabolic process; dicarboxylic acid transmembrane transporter activity; gluconeogenesis; integral to membrane; malate transmembrane transporter activity; mitochondrial inner membrane; mitochondrial transport; nucleus; phosphate ion transmembrane transporter activity; succinate transmembrane transporter activity; sulfate transmembrane transporter activity; sulfate transport; sulfide oxidation, using sulfide:quinone oxidoreductase; sulfur amino acid catabolic process; thiosulfate transmembrane transporter activity; thiosulfate transport" IPR002030; IPR018108; IPR023395; Mitochondrial dicarboxylate carrier (Solute carrier family 25 member 10) SLC25A10 DIC Homo sapiens (Human) TR38568_c3_g1_i3 266.184 5.453 5.044 0.231 1.014 0.000 O42163 COCH_CHICK 1.00E-13 GO:0005576; GO:0008360; GO:0007605 extracellular region; regulation of cell shape; sensory perception of sound IPR004043; IPR002035; Cochlin (COCH-5B2) COCH COCH5B2 Gallus gallus (Chicken) TR38604_c0_g1_i2 0.000 0.051 0.016 8.078 2.968 0.000 Q9UBQ7 GRHPR_HUMAN 3.00E-98 GO:0051287; GO:0070402; GO:0034641; GO:0007588; GO:0008465; GO:0046487; GO:0030267; GO:0016618; GO:0005782; GO:0042803; GO:0051259 NAD binding; NADPH binding; cellular nitrogen compound metabolic process; excretion; glycerate dehydrogenase activity; glyoxylate metabolic process; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; peroxisomal matrix; protein homodimerization activity; protein oligomerization IPR006139; IPR006140; IPR016040; Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) GRHPR GLXR MSTP035 Homo sapiens (Human) TR38604_c0_g1_i3 55.128 69.431 0.000 32.625 13.088 33.260 Q57IH8 GHRB_SALCH 7.00E-42 GO:0051287; GO:0005737; GO:0030267; GO:0016618; GO:0005886 NAD binding; cytoplasm; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; plasma membrane IPR006139; IPR006140; IPR023756; IPR016040; Glyoxylate/hydroxypyruvate reductase B (EC 1.1.1.79) (EC 1.1.1.81) ghrB SCH_3578 Salmonella choleraesuis (strain SC-B67) TR38741_c0_g1_i3 0.000 4.909 5.651 9.557 5.355 1.250 Q11039 DEAD_MYCTU 3.00E-76 GO:0005524; GO:0008026; GO:0003723; GO:0005618; GO:0005829; GO:0006950 ATP binding; ATP-dependent helicase activity; RNA binding; cell wall; cytosol; response to stress IPR005580; IPR011545; IPR014001; IPR001650; IPR027417; IPR000629; IPR014014; ATP-dependent RNA helicase DeaD (EC 3.6.4.13) (Cold-shock DEAD box protein A) deaD csdA Rv1253 MT1292 MTCY50.29c Mycobacterium tuberculosis TR38821_c0_g1_i3 1.056 0.114 0.000 7.692 5.686 0.007 Q5XH94 TIM23_XENTR 2.00E-27 GO:0015450; GO:0016021; GO:0006886; GO:0005744 P-P-bond-hydrolysis-driven protein transmembrane transporter activity; integral to membrane; intracellular protein transport; mitochondrial inner membrane presequence translocase complex IPR003397; IPR005681; Mitochondrial import inner membrane translocase subunit Tim23 timm23 timm23b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR38826_c0_g1_i1 4.177 2.086 0.000 6.372 5.589 0.564 Q8C854 MYEF2_MOUSE 3.00E-53 GO:0003677; GO:0003723; GO:0000166; GO:0005634; GO:0006351 "DNA binding; RNA binding; nucleotide binding; nucleus; transcription, DNA-dependent" IPR012677; IPR000504; Myelin expression factor 2 (MEF-2) (MyEF-2) Myef2 Kiaa1341 Mef2 Mus musculus (Mouse) TR38963_c0_g2_i3 17.727 2.837 0.000 0.147 0.053 0.131 P84675 PFM_CHAGB 1.00E-08 GO:0050832; GO:0031640 defense response to fungus; killing of cells of other organism IPR002889; IPR013994; Putative fungistatic metabolite CHGG_05463 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) TR39118_c1_g1_i10 0.000 0.000 0.000 3.050 0.918 0.000 O43679 LDB2_HUMAN 2.00E-163 GO:0030274; GO:0010669; GO:0001942; GO:0005634; GO:0044089; GO:0045944; GO:0035019; GO:0003712; GO:0005667 LIM domain binding; epithelial structure maintenance; hair follicle development; nucleus; positive regulation of cellular component biogenesis; positive regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance; transcription cofactor activity; transcription factor complex IPR002691; LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1) LDB2 CLIM1 Homo sapiens (Human) TR39139_c4_g2_i1 0.000 0.500 0.000 4.661 0.630 0.000 O46037 VINC_DROME 0 GO:0003779; GO:0015629; GO:0007155; GO:0005737; GO:0007016; GO:0005925; GO:0048812; GO:0006909; GO:0005886; GO:0005198 actin binding; actin cytoskeleton; cell adhesion; cytoplasm; cytoskeletal anchoring at plasma membrane; focal adhesion; neuron projection morphogenesis; phagocytosis; plasma membrane; structural molecule activity IPR017997; IPR006077; IPR000633; Vinculin Vinc CG3299 Drosophila melanogaster (Fruit fly) TR39139_c4_g2_i2 0.878 0.093 0.929 4.763 0.843 0.000 O46037 VINC_DROME 0 GO:0003779; GO:0015629; GO:0007155; GO:0005737; GO:0007016; GO:0005925; GO:0048812; GO:0006909; GO:0005886; GO:0005198 actin binding; actin cytoskeleton; cell adhesion; cytoplasm; cytoskeletal anchoring at plasma membrane; focal adhesion; neuron projection morphogenesis; phagocytosis; plasma membrane; structural molecule activity IPR017997; IPR006077; IPR000633; Vinculin Vinc CG3299 Drosophila melanogaster (Fruit fly) TR39177_c2_g1_i2 17.515 5.474 1.260 0.000 0.007 1.388 Q6L6Q6 LYS_CRAGI 2.00E-33 GO:0019835; GO:0042742; GO:0005576; GO:0003796 cytolysis; defense response to bacterium; extracellular region; lysozyme activity IPR008597; IPR023346; "Lysozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase)" lysoz Crassostrea gigas (Pacific oyster) (Crassostrea angulata) TR39297_c3_g1_i5 1.778 0.322 0.000 1.780 0.357 0.000 G5EBZ4 LE418_CAEEL 0 GO:0005524; GO:0008026; GO:0003677; GO:0016581; GO:0048557; GO:0000122; GO:0040027; GO:0008270 Q21502 ATP binding; ATP-dependent helicase activity; DNA binding; NuRD complex; embryonic digestive tract morphogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of vulval development; zinc ion binding IPR012957; IPR012958; IPR023780; IPR000953; IPR016197; IPR002464; IPR009462; IPR009463; IPR014001; IPR001650; IPR027417; IPR000330; IPR019786; IPR011011; IPR001965; IPR019787; IPR001841; IPR013083; Protein let-418 (Lethal protein 418) let-418 evl-11 F26F12.7 Caenorhabditis elegans TR39321_c0_g1_i1 6.821 4.546 14.743 0.000 0.000 0.000 P05202 AATM_MOUSE 0 GO:0004069; GO:0080130; GO:0006532; GO:0006533; GO:0015908; GO:0019551; GO:0019550; GO:0016212; GO:0005743; GO:0005759; GO:0006107; GO:0005886; GO:0030170; GO:0045471 L-aspartate:2-oxoglutarate aminotransferase activity; L-phenylalanine:2-oxoglutarate aminotransferase activity; aspartate biosynthetic process; aspartate catabolic process; fatty acid transport; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; kynurenine-oxoglutarate transaminase activity; mitochondrial inner membrane; mitochondrial matrix; oxaloacetate metabolic process; plasma membrane; pyridoxal phosphate binding; response to ethanol IPR004839; IPR000796; IPR004838; IPR015424; IPR015421; "Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)" Got2 Got-2 Mus musculus (Mouse) TR39321_c0_g1_i6 0.000 18.711 0.000 23.972 17.182 0.415 P05202 AATM_MOUSE 0 GO:0004069; GO:0080130; GO:0006532; GO:0006533; GO:0015908; GO:0019551; GO:0019550; GO:0016212; GO:0005743; GO:0005759; GO:0006107; GO:0005886; GO:0030170; GO:0045471 L-aspartate:2-oxoglutarate aminotransferase activity; L-phenylalanine:2-oxoglutarate aminotransferase activity; aspartate biosynthetic process; aspartate catabolic process; fatty acid transport; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; kynurenine-oxoglutarate transaminase activity; mitochondrial inner membrane; mitochondrial matrix; oxaloacetate metabolic process; plasma membrane; pyridoxal phosphate binding; response to ethanol IPR004839; IPR000796; IPR004838; IPR015424; IPR015421; "Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)" Got2 Got-2 Mus musculus (Mouse) TR39323_c3_g1_i2 0.000 0.000 2.591 11.278 1.105 0.022 Q95NI4 CALM_HALOK 3.00E-44 GO:0005509 calcium ion binding IPR011992; IPR018247; IPR002048; Calmodulin (CaM) Halichondria okadai (Marine sponge) (Reniera okadai) TR39394_c3_g2_i3 7.767 4.872 2.648 26.441 4.380 0.000 Q24800 SEVE_ECHGR 4.00E-98 GO:0051693 actin filament capping IPR007123; IPR007122; Severin AG8 Echinococcus granulosus TR39432_c2_g2_i2 229.063 1.388 25.432 49.473 40.936 0.008 Q4PMB3 RS4_IXOSC 2.00E-144 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR005824; IPR000876; IPR013845; IPR013843; IPR018199; IPR002942; 40S ribosomal protein S4 RpS4 Ixodes scapularis (Black-legged tick) (Deer tick) TR39432_c2_g2_i6 34.752 735.412 166.724 1.511 0.000 114.428 Q9YF85 RS4E_AERPE 6.00E-42 GO:0019843; GO:0005840; GO:0003735; GO:0006412 rRNA binding; ribosome; structural constituent of ribosome; translation IPR000876; IPR013845; IPR013843; IPR002942; 30S ribosomal protein S4e rps4e APE_0356.1 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) TR39433_c1_g3_i1 33.872 95.455 11.092 0.000 0.241 2.623 P83425 HIP_MYTED 6.00E-08 GO:0005576; GO:0046872 extracellular region; metal ion binding IPR001073; IPR008983; Heavy metal-binding protein HIP Mytilus edulis (Blue mussel) TR39433_c1_g3_i2 0.000 0.000 0.000 5.379 10.360 67.585 Q9JHG0 CBLN3_MOUSE 3.00E-08 GO:0005794; GO:0030054; GO:0005783; GO:0005615; GO:0045202 Golgi apparatus; cell junction; endoplasmic reticulum; extracellular space; synapse IPR001073; IPR008983; Cerebellin-3 Cbln3 Mus musculus (Mouse) TR39433_c1_g3_i3 240.941 65.455 0.542 23.108 41.787 0.078 Q8R066 C1QT4_MOUSE 7.00E-08 GO:0005615 extracellular space IPR001073; IPR008983; Complement C1q tumor necrosis factor-related protein 4 C1qtnf4 Mus musculus (Mouse) TR39465_c1_g1_i4 1.136 0.291 0.000 4.141 1.277 0.000 Q1PEI6 FACR8_ARATH 3.00E-44 GO:0080019; GO:0006629 fatty-acyl-CoA reductase (alcohol-forming) activity; lipid metabolic process IPR026055; IPR013120; IPR016040; Fatty acyl-CoA reductase 8 (EC 1.2.1.n2) FAR8 At3g44560 F14L2.110 Arabidopsis thaliana (Mouse-ear cress) TR39475_c0_g3_i3 0.001 0.189 0.229 2.692 1.657 0.000 Q9H172 ABCG4_HUMAN 4.00E-151 GO:0005524; GO:0006200; GO:0016887; GO:0033344; GO:0017127; GO:0016021; GO:0005886; GO:0042803; GO:0055085 P45844-4 ATP binding; ATP catabolic process; ATPase activity; cholesterol efflux; cholesterol transporter activity; integral to membrane; plasma membrane; protein homodimerization activity; transmembrane transport IPR003593; IPR013525; IPR003439; IPR017871; IPR027417; ATP-binding cassette sub-family G member 4 ABCG4 WHITE2 Homo sapiens (Human) TR39495_c0_g1_i7 0.363 0.000 0.000 2.983 0.509 0.266 Q5E936 TXD12_BOVIN 1.00E-36 GO:0045454; GO:0005788; GO:0019153 cell redox homeostasis; endoplasmic reticulum lumen; protein-disulfide reductase (glutathione) activity IPR012336; IPR017937; Thioredoxin domain-containing protein 12 (EC 1.8.4.2) TXNDC12 Bos taurus (Bovine) TR39504_c0_g1_i4 0.000 0.000 13.741 2.270 5.235 0.000 Q8K2W3 TXD11_MOUSE 3.00E-06 GO:0045454; GO:0005789; GO:0016021 cell redox homeostasis; endoplasmic reticulum membrane; integral to membrane IPR012336; IPR013766; Thioredoxin domain-containing protein 11 Txndc11 Mus musculus (Mouse) TR39748_c0_g3_i1 0.000 0.990 2.766 14.485 1.818 0.000 P42669 PURA_MOUSE 8.00E-76 GO:0005662; GO:0006268; GO:0046332; GO:0006915; GO:0030154; GO:0008283; GO:0005737; GO:0030425; GO:0003690; GO:0003691; GO:0007093; GO:0045892; GO:0007399; GO:0043025; GO:0008284; GO:0032422; GO:0003700; GO:0003697; GO:0006351; GO:0000900 "DNA replication factor A complex; DNA unwinding involved in DNA replication; SMAD binding; apoptotic process; cell differentiation; cell proliferation; cytoplasm; dendrite; double-stranded DNA binding; double-stranded telomeric DNA binding; mitotic cell cycle checkpoint; negative regulation of transcription, DNA-dependent; nervous system development; neuronal cell body; positive regulation of cell proliferation; purine-rich negative regulatory element binding; sequence-specific DNA binding transcription factor activity; single-stranded DNA binding; transcription, DNA-dependent; translation repressor activity, nucleic acid binding" IPR006628; Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha) Pura Mus musculus (Mouse) TR39749_c1_g1_i1 0.044 0.000 0.000 7.489 4.478 0.014 P05400 POL_CERV 2.00E-08 GO:0003723; GO:0006278; GO:0003964; GO:0004190; GO:0004519; GO:0090305; GO:0006508 RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; aspartic-type endopeptidase activity; endonuclease activity; nucleic acid phosphodiester bond hydrolysis; proteolysis IPR000588; IPR000477; Enzymatic polyprotein [Includes: Aspartic protease (EC 3.4.23.-); Endonuclease; Reverse transcriptase (EC 2.7.7.49)] ORF V Carnation etched ring virus (CERV) TR39749_c1_g1_i2 0.025 0.604 0.000 7.686 2.891 0.000 O50655 XERD_SELRU 1.00E-09 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR39797_c0_g1_i2 0.000 0.183 0.000 3.087 6.950 0.000 Q6AZG6 SYFAA_XENLA 0 GO:0005524; GO:0005737; GO:0004826; GO:0006432; GO:0000049 ATP binding; cytoplasm; phenylalanine-tRNA ligase activity; phenylalanyl-tRNA aminoacylation; tRNA binding IPR006195; IPR004529; IPR002319; Phenylalanine--tRNA ligase alpha subunit A (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit A) (PheRS) farsa-a farsla-a Xenopus laevis (African clawed frog) TR39821_c3_g3_i2 0.016 22.591 0.012 0.000 0.000 0.000 P49300 CLC10_MOUSE 1.00E-14 GO:0030246; GO:0016021 carbohydrate binding; integral to membrane IPR001304; IPR016186; IPR018378; IPR016187; IPR005640; C-type lectin domain family 10 member A (MMGL) (Macrophage asialoglycoprotein-binding protein 1) (M-ASGP-BP-1) (Macrophage galactose/N-acetylgalactosamine-specific lectin) Clec10a Mgl Mgl1 Mus musculus (Mouse) TR39827_c0_g1_i2 0.000 0.000 0.062 3.138 0.822 0.073 P70549 NAC3_RAT 2.00E-85 GO:1990034; GO:1990035; GO:0060402; GO:0005432; GO:0007154; GO:0071320; GO:0043197; GO:0016021; GO:0005874; GO:0005739; GO:0043025; GO:0042383; GO:0021537 calcium ion export from cell; calcium ion import into cell; calcium ion transport into cytosol; calcium:sodium antiporter activity; cell communication; cellular response to cAMP; dendritic spine; integral to membrane; microtubule; mitochondrion; neuronal cell body; sarcolemma; telencephalon development IPR003644; IPR004836; IPR004837; Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) Slc8a3 Ncx3 Rattus norvegicus (Rat) TR39900_c1_g3_i1 7.510 34.772 65.132 0.000 0.477 0.382 Q8IUK8 CBLN2_HUMAN 3.00E-09 GO:0005615; GO:0051965 extracellular space; positive regulation of synapse assembly IPR001073; IPR008983; Cerebellin-2 CBLN2 UNQ1892/PRO4338 Homo sapiens (Human) TR39900_c1_g4_i1 0.000 0.118 0.000 10.478 4.212 0.000 Q00780 CO8A1_MOUSE 2.00E-07 GO:0001525; GO:0005604; GO:0048593; GO:0007155; GO:0005581; GO:0050673; GO:0010811 angiogenesis; basement membrane; camera-type eye morphogenesis; cell adhesion; collagen; epithelial cell proliferation; positive regulation of cell-substrate adhesion IPR001073; IPR008160; IPR008983; Collagen alpha-1(VIII) chain [Cleaved into: Vastatin] Col8a1 Mus musculus (Mouse) TR40033_c0_g1_i6 0.000 17.640 0.000 3.422 4.187 3.128 P84096 RHOG_MOUSE 3.00E-40 GO:0005525; GO:0003924; GO:0016601; GO:0007266; GO:0030036; GO:0032863; GO:0060326; GO:0005622; GO:0005886; GO:0090004; GO:0045893 "GTP binding; GTPase activity; Rac protein signal transduction; Rho protein signal transduction; actin cytoskeleton organization; activation of Rac GTPase activity; cell chemotaxis; intracellular; plasma membrane; positive regulation of establishment of protein localization to plasma membrane; positive regulation of transcription, DNA-dependent" IPR027417; IPR005225; IPR001806; IPR003578; Rho-related GTP-binding protein RhoG (Sid 10750) Rhog Arhg Sid10750 Mus musculus (Mouse) TR40081_c3_g1_i5 1.530 0.172 66.919 0.044 0.000 1.178 P83553 DERM_BIOGL 8.00E-23 GO:0007155; GO:0005578 cell adhesion; proteinaceous extracellular matrix IPR026645; Dermatopontin (Tyrosine-rich acidic matrix protein) (TRAMP) Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail) TR40190_c0_g1_i1 0.408 0.121 0.000 4.518 3.344 0.113 P74897 YQA3_THEAQ 2.00E-10 GO:0006950 response to stress IPR014729; IPR006015; IPR006016; Universal stress protein in QAH/OAS sulfhydrylase 3'region (USP) Thermus aquaticus TR40209_c8_g1_i5 0.676 837.171 632.554 1.448 59.461 4.375 Q9H853 TBA4B_HUMAN 4.00E-83 GO:0005525; GO:0005737; GO:0005874; GO:0007017; GO:0005200 GTP binding; cytoplasm; microtubule; microtubule-based process; structural constituent of cytoskeleton IPR002452; IPR000217; IPR003008; Putative tubulin-like protein alpha-4B (Alpha-tubulin 4B) TUBA4B TUBA4 Homo sapiens (Human) TR40253_c2_g2_i3 552.648 20.809 0.469 0.000 0.140 0.939 P82103 MYNA_MYTGA 4.00E-24 GO:0042742; GO:0005576 defense response to bacterium; extracellular region IPR019631; Myticin-A Mytilus galloprovincialis (Mediterranean mussel) TR40253_c2_g2_i4 9367.686 6274.743 520.505 4.358 171.966 18.037 P82102 MYNB_MYTGA 1.00E-23 GO:0042742; GO:0050832; GO:0005576; GO:0031640 defense response to bacterium; defense response to fungus; extracellular region; killing of cells of other organism IPR019631; Myticin-B Mytilus galloprovincialis (Mediterranean mussel) TR40309_c4_g1_i5 0.000 7.457 0.000 2.319 12.587 0.829 Q8MJV2 NPBW2_BOVIN 1.00E-13 GO:0016021; GO:0008188; GO:0007218; GO:0005886 integral to membrane; neuropeptide receptor activity; neuropeptide signaling pathway; plasma membrane IPR000276; IPR017452; IPR009150; IPR027349; Neuropeptides B/W receptor type 2 (G-protein coupled receptor 8) NPBWR2 GPR8 Bos taurus (Bovine) TR40427_c3_g3_i12 3.000 1.453 2.931 0.000 0.000 0.296 Q19157 PIN2_CAEEL 4.00E-65 GO:0005737; GO:0005634; GO:0043196; GO:0008270 cytoplasm; nucleus; varicosity; zinc ion binding IPR017351; IPR001781; LIM domain-containing protein pin-2 pin-2 F07C6.1 Caenorhabditis elegans TR40427_c3_g3_i4 19.051 6.928 0.000 14.305 18.227 7.539 Q19157 PIN2_CAEEL 4.00E-65 GO:0005737; GO:0005634; GO:0043196; GO:0008270 cytoplasm; nucleus; varicosity; zinc ion binding IPR017351; IPR001781; LIM domain-containing protein pin-2 pin-2 F07C6.1 Caenorhabditis elegans TR40446_c0_g2_i2 1.365 0.795 0.000 9.360 1.643 1.493 Q1LUC1 BZW2_DANRE 5.00E-105 GO:0030154; GO:0007399 cell differentiation; nervous system development IPR016024; IPR016021; IPR003307; Basic leucine zipper and W2 domain-containing protein 2 bzw2 si:ch211-210b19.1 zgc:55580 Danio rerio (Zebrafish) (Brachydanio rerio) TR40503_c1_g1_i2 0.370 0.209 0.356 3.004 0.896 0.000 Q90693 PTC1_CHICK 4.00E-30 GO:0008158; GO:0005887; GO:0007224 hedgehog receptor activity; integral to plasma membrane; smoothened signaling pathway IPR003392; IPR000731; IPR004766; Protein patched homolog 1 (PTC) (PTC1) PTCH1 PTC PTCH Gallus gallus (Chicken) TR40580_c2_g2_i2 0.000 0.205 0.000 6.737 2.586 0.000 O15084 ANR28_HUMAN 2.00E-17 GO:0005654 Q14185; O00743; Q9UPN7; O75170; Q5H9R7; Q9H2K2 nucleoplasm IPR002110; IPR020683; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) ANKRD28 KIAA0379 Homo sapiens (Human) TR40637_c0_g1_i8 0.000 17.211 0.000 7.536 10.110 8.028 P28049 LAB_XENLA 8.00E-33 GO:0003723; GO:0006396; GO:0000166; GO:0005634; GO:0030529 RNA binding; RNA processing; nucleotide binding; nucleus; ribonucleoprotein complex IPR002344; IPR006630; IPR012677; IPR014886; IPR000504; IPR011991; Lupus La protein homolog B (La autoantigen homolog B) (La ribonucleoprotein B) ssb-b lab1 Xenopus laevis (African clawed frog) TR40640_c2_g3_i6 0.002 0.615 0.000 4.536 0.684 0.090 Q08E13 RNF10_BOVIN 2.00E-112 GO:0005737; GO:0045893; GO:0008270 "cytoplasm; positive regulation of transcription, DNA-dependent; zinc ion binding" IPR001841; IPR013083; IPR017907; RING finger protein 10 RNF10 Bos taurus (Bovine) TR40705_c2_g1_i5 0.019 0.000 12.613 39.652 77.133 0.114 P10675 FAS1_SCHAM 1.00E-14 GO:0031225; GO:0007155; GO:0005886 anchored to membrane; cell adhesion; plasma membrane IPR000782; Fasciclin-1 (Fasciclin I) (FAS I) (FCN) FAS1 Schistocerca americana (American grasshopper) TR40732_c1_g2_i1 0.000 0.339 3.116 0.000 0.000 0.005 A2AJ76 HMCN2_MOUSE 7.00E-58 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR40732_c1_g2_i2 0.420 0.000 0.008 2.841 14.945 0.000 A2AJ76 HMCN2_MOUSE 7.00E-58 GO:0005604; GO:0005509; GO:0005938; GO:0030054; GO:0050896 basement membrane; calcium ion binding; cell cortex; cell junction; response to stimulus IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR018097; IPR006605; IPR009017; IPR023413; IPR009030; IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR002035; Hemicentin-2 Hmcn2 Mus musculus (Mouse) TR40810_c2_g1_i3 0.096 118.186 4.054 15.986 23.696 2.148 P22757 HE_PARLI 2.00E-50 GO:0031012; GO:0004222; GO:0006508; GO:0008270 extracellular matrix; metalloendopeptidase activity; proteolysis; zinc ion binding IPR000585; IPR018487; IPR024079; IPR001818; IPR021190; IPR021158; IPR006026; IPR002477; Hatching enzyme (HE) (HEZ) (EC 3.4.24.12) (Envelysin) (Sea-urchin-hatching proteinase) [Cleaved into: Hatching enzyme 18 kDa form] Paracentrotus lividus (Common sea urchin) TR40810_c2_g1_i5 0.000 59.918 0.000 137.707 337.049 0.000 P22757 HE_PARLI 5.00E-52 GO:0031012; GO:0004222; GO:0006508; GO:0008270 extracellular matrix; metalloendopeptidase activity; proteolysis; zinc ion binding IPR000585; IPR018487; IPR024079; IPR001818; IPR021190; IPR021158; IPR006026; IPR002477; Hatching enzyme (HE) (HEZ) (EC 3.4.24.12) (Envelysin) (Sea-urchin-hatching proteinase) [Cleaved into: Hatching enzyme 18 kDa form] Paracentrotus lividus (Common sea urchin) TR40852_c1_g2_i4 0.000 0.839 0.639 7.763 1.834 0.365 O46339 HTH_DROME 2.00E-65 GO:0003677; GO:0003705; GO:0007420; GO:0001752; GO:0005737; GO:0048735; GO:0007480; GO:0007476; GO:0007479; GO:0005634; GO:0007422; GO:0045944; GO:0000060; GO:0042659; GO:0045664; GO:0007432; GO:0043565; GO:0007525; GO:0010092; GO:0007383; GO:0005667 P40427 "DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; brain development; compound eye photoreceptor fate commitment; cytoplasm; haltere morphogenesis; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; leg disc proximal/distal pattern formation; nucleus; peripheral nervous system development; positive regulation of transcription from RNA polymerase II promoter; protein import into nucleus, translocation; regulation of cell fate specification; regulation of neuron differentiation; salivary gland boundary specification; sequence-specific DNA binding; somatic muscle development; specification of organ identity; specification of segmental identity, antennal segment; transcription factor complex" IPR001356; IPR008422; IPR009057; Homeobox protein homothorax (Homeobox protein dorsotonals) hth dtl CG17117 Drosophila melanogaster (Fruit fly) TR40905_c2_g2_i3 0.000 0.719 0.000 4.713 0.653 0.000 Q17QJ5 TSN5_BOVIN 5.00E-20 GO:0016021 integral to membrane IPR000301; IPR018499; IPR018503; IPR008952; Tetraspanin-5 (Tspan-5) TSPAN5 Bos taurus (Bovine) TR40931_c1_g1_i1 3.277 1.342 0.000 1.606 2.256 0.346 P46100 ATRX_HUMAN 3.00E-172 GO:0005524; GO:0003677; GO:0003678; GO:0006306; GO:0006310; GO:0006281; GO:0003682; GO:0030900; GO:0005720; GO:0006355; GO:0008270 Q9UER7 "ATP binding; DNA binding; DNA helicase activity; DNA methylation; DNA recombination; DNA repair; chromatin binding; forebrain development; nuclear heterochromatin; regulation of transcription, DNA-dependent; zinc ion binding" IPR025766; IPR014001; IPR001650; IPR027417; IPR000330; IPR011011; IPR001841; IPR013083; Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) ATRX RAD54L XH2 Homo sapiens (Human) TR40965_c0_g1_i2 1.569 0.864 0.000 10.035 6.426 0.046 O55096 DPP3_RAT 0 GO:0004177; GO:0005737; GO:0008239; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; cytoplasm; dipeptidyl-peptidase activity; metallopeptidase activity; proteolysis; zinc ion binding IPR005317; Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) Dpp3 Rattus norvegicus (Rat) TR40986_c1_g1_i14 0.109 0.224 0.000 6.182 0.242 0.000 Q9PW72 PDLI4_CHICK 1.00E-13 GO:0008270 zinc ion binding IPR001478; IPR001781; PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) PDLIM4 RIL Gallus gallus (Chicken) TR40986_c1_g1_i2 0.927 0.000 0.000 7.696 0.479 0.000 A1ZA47 ZASP_DROME 3.00E-67 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR40986_c1_g1_i9 0.000 0.385 0.000 5.240 0.624 0.265 Q9PW72 PDLI4_CHICK 1.00E-13 GO:0008270 zinc ion binding IPR001478; IPR001781; PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) PDLIM4 RIL Gallus gallus (Chicken) TR41121_c3_g2_i2 0.082 0.033 0.000 9.404 1.403 0.003 O75534 CSDE1_HUMAN 1.00E-128 GO:0070937; GO:0003677; GO:0003723; GO:0008584; GO:0070966; GO:0006355 "CRD-mediated mRNA stability complex; DNA binding; RNA binding; male gonad development; nuclear-transcribed mRNA catabolic process, no-go decay; regulation of transcription, DNA-dependent" IPR019844; IPR011129; IPR002059; IPR012340; IPR024642; Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) CSDE1 D1S155E KIAA0885 NRU UNR Homo sapiens (Human) TR41198_c1_g2_i10 0.555 0.184 0.579 8.129 0.283 0.000 Q7RTX9 MOT14_HUMAN 3.00E-29 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR41198_c1_g2_i2 2.357 0.800 0.000 0.944 0.393 1.228 Q7RTX9 MOT14_HUMAN 6.00E-29 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR41198_c1_g2_i4 0.000 0.000 0.399 7.210 0.875 0.002 Q7RTX9 MOT14_HUMAN 6.00E-29 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) TR41203_c0_g1_i5 6.404 0.256 0.000 0.000 0.000 0.000 Q9VQ62 NPC2_DROME 8.00E-27 GO:0045456; GO:0005615; GO:0030882; GO:0001530; GO:0070891; GO:0042834; GO:0061057; GO:0055092; GO:0015918; GO:0008039 Q9VPU1 ecdysteroid biosynthetic process; extracellular space; lipid antigen binding; lipopolysaccharide binding; lipoteichoic acid binding; peptidoglycan binding; peptidoglycan recognition protein signaling pathway; sterol homeostasis; sterol transport; synaptic target recognition IPR014756; IPR003172; Protein NPC2 homolog (Niemann Pick type C2 protein homolog) Npc2a NPC2 CG7291 Drosophila melanogaster (Fruit fly) TR41238_c1_g1_i7 1.699 1.931 0.405 4.067 2.861 0.000 P41778 PBX1_MOUSE 7.00E-148 GO:0001077; GO:0030325; GO:0009952; GO:0001658; GO:0005737; GO:0035162; GO:0030326; GO:0048706; GO:0045665; GO:0043433; GO:0005634; GO:0009887; GO:0010971; GO:0008284; GO:0009954; GO:0030278; GO:0043565; GO:0007548; GO:0048536; GO:0006694; GO:0048538; GO:0005667 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; adrenal gland development; anterior/posterior pattern specification; branching involved in ureteric bud morphogenesis; cytoplasm; embryonic hemopoiesis; embryonic limb morphogenesis; embryonic skeletal system development; negative regulation of neuron differentiation; negative regulation of sequence-specific DNA binding transcription factor activity; nucleus; organ morphogenesis; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of cell proliferation; proximal/distal pattern formation; regulation of ossification; sequence-specific DNA binding; sex differentiation; spleen development; steroid biosynthetic process; thymus development; transcription factor complex IPR017970; IPR001356; IPR009057; IPR005542; Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) Pbx1 Pbx-1 Mus musculus (Mouse) TR41260_c2_g1_i4 0.068 0.049 0.000 2.650 1.130 0.103 P10351 XDH_DROME 0 GO:0051537; GO:0008762; GO:0006525; GO:0048072; GO:0008340; GO:0009055; GO:0050660; GO:0006650; GO:0005506; GO:0005875; GO:0043546; GO:0005777; GO:0006206; GO:0006568; GO:0009115; GO:0004854; GO:0004855 "2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; arginine metabolic process; compound eye pigmentation; determination of adult lifespan; electron carrier activity; flavin adenine dinucleotide binding; glycerophospholipid metabolic process; iron ion binding; microtubule associated complex; molybdopterin cofactor binding; peroxisome; pyrimidine nucleobase metabolic process; tryptophan metabolic process; xanthine catabolic process; xanthine dehydrogenase activity; xanthine oxidase activity" IPR002888; IPR001041; IPR006058; IPR000674; IPR016208; IPR008274; IPR012675; IPR005107; IPR016169; IPR016166; IPR016167; IPR002346; IPR022407; IPR014307; Xanthine dehydrogenase (XD) (EC 1.17.1.4) (Protein rosy locus) ry XDH CG7642 Drosophila melanogaster (Fruit fly) TR41272_c3_g1_i3 0.069 34.187 7.429 39.935 71.218 14.897 P0CAT2 S238B_DANRE 9.00E-79 GO:0030218; GO:0016021; GO:0005743; GO:0055085 erythrocyte differentiation; integral to membrane; mitochondrial inner membrane; transmembrane transport IPR002067; IPR018108; IPR023395; Solute carrier family 25 member 38-B slc25a38b Danio rerio (Zebrafish) (Brachydanio rerio) TR41300_c1_g1_i8 1.214 0.439 0.000 7.471 17.963 0.059 Q00453 RGM1_YEAST 1.00E-07 GO:0003677; GO:0005829; GO:0046872; GO:0000790; GO:0045944; GO:0000981 P39940 DNA binding; cytosol; metal ion binding; nuclear chromatin; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding RNA polymerase II transcription factor activity IPR007087; IPR015880; IPR013087; Probable transcription repressor protein RGM1 RGM1 YMR182C YM8010.12C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR41330_c0_g6_i1 1.363 0.163 0.000 1.000 1.612 86.834 Q8VD98 KLRBF_MOUSE 6.00E-07 GO:0030246; GO:0009986; GO:0016021; GO:0005886; GO:0004872 carbohydrate binding; cell surface; integral to membrane; plasma membrane; receptor activity IPR001304; IPR016186; IPR016187; Killer cell lectin-like receptor subfamily B member 1F (CD161 antigen-like family member F) (Natural killer cell surface protein NKR-P1F) (CD antigen CD161f) Klrb1f Nkrp1f Mus musculus (Mouse) TR41392_c0_g2_i2 5.355 1.040 0.000 0.000 0.000 0.420 Q7ZTY4 RBBP7_DANRE 0 GO:0006260; GO:0035098; GO:0016568; GO:0006355; GO:0006351 "DNA replication; ESC/E(Z) complex; chromatin modification; regulation of transcription, DNA-dependent; transcription, DNA-dependent" IPR020472; IPR022052; IPR015943; IPR001680; IPR019775; IPR017986; Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) rbbp7 rbb4l Danio rerio (Zebrafish) (Brachydanio rerio) TR41394_c0_g1_i2 0.005 0.136 0.186 3.097 36.130 0.028 Q18439 NAS8_CAEEL 4.00E-27 GO:0005576; GO:0004222; GO:0006508; GO:0008270 extracellular region; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR001506; IPR017367; IPR006026; IPR003582; Zinc metalloproteinase nas-8 (EC 3.4.24.21) (Nematode astacin 8) nas-8 C34D4.9 Caenorhabditis elegans TR41402_c1_g4_i2 0.000 0.000 0.000 8.341 0.466 0.000 P97300 NPTN_MOUSE 1.00E-06 GO:0050839; GO:0007204; GO:0007156; GO:0016021; GO:0060291; GO:0045743; GO:0048170; GO:0010976; GO:0001934; GO:0042734; GO:0005105 cell adhesion molecule binding; elevation of cytosolic calcium ion concentration; homophilic cell adhesion; integral to membrane; long-term synaptic potentiation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; positive regulation of neuron projection development; positive regulation of protein phosphorylation; presynaptic membrane; type 1 fibroblast growth factor receptor binding IPR007110; IPR013783; IPR013098; IPR003599; IPR003598; IPR027112; Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) Nptn Sdfr1 Sdr1 Mus musculus (Mouse) TR41418_c0_g1_i3 0.000 0.645 0.000 14.362 0.000 0.000 P25169 AT1B1_ARTSF 2.00E-59 GO:0006813; GO:0006814; GO:0005890 potassium ion transport; sodium ion transport; sodium:potassium-exchanging ATPase complex IPR000402; Sodium/potassium-transporting ATPase subunit beta (Sodium/potassium-dependent ATPase beta subunit) Artemia franciscana (Brine shrimp) (Artemia sanfranciscana) TR41419_c1_g1_i2 0.000 1.840 0.000 4.255 2.537 1.898 Q55CQ7 TNPO_DICDI 2.00E-161 GO:0005829; GO:0005635; GO:0008139; GO:0006606 cytosol; nuclear envelope; nuclear localization sequence binding; protein import into nucleus IPR011989; IPR016024; IPR001494; Transportin (Importin subunit beta) (Karyopherin subunit beta) tnpo DDB_G0269948 Dictyostelium discoideum (Slime mold) TR41419_c1_g1_i6 2.912 0.112 0.000 2.619 0.408 0.000 Q8BFY9 TNPO1_MOUSE 0 GO:0005737; GO:0006886; GO:0005634 cytoplasm; intracellular protein transport; nucleus IPR011989; IPR016024; IPR001494; Transportin-1 (Importin beta-2) (Karyopherin beta-2) Tnpo1 Kpnb2 Mus musculus (Mouse) TR41435_c3_g1_i8 0.000 15.813 39.185 59.750 28.273 0.198 P18091 ACTN_DROME 0 GO:0030018; GO:0003779; GO:0031532; GO:0005509; GO:0007016; GO:0007629; GO:0005925; GO:0045214 Z disc; actin binding; actin cytoskeleton reorganization; calcium ion binding; cytoskeletal anchoring at plasma membrane; flight behavior; focal adhesion; sarcomere organization IPR001589; IPR001715; IPR011992; IPR014837; IPR018247; IPR002048; IPR018159; IPR002017; "Alpha-actinin, sarcomeric (F-actin cross-linking protein)" Actn fliA l(1)2Cb CG4376 Drosophila melanogaster (Fruit fly) TR41472_c0_g1_i10 0.000 0.000 0.000 3.595 0.476 0.000 Q5SF07 IF2B2_MOUSE 7.00E-56 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) Igf2bp2 Imp2 Vickz2 Mus musculus (Mouse) TR41472_c0_g1_i15 1.144 0.000 0.479 6.390 3.201 0.000 Q5SF07 IF2B2_MOUSE 7.00E-56 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) Igf2bp2 Imp2 Vickz2 Mus musculus (Mouse) TR41472_c0_g1_i18 0.167 0.816 1.146 0.000 0.000 0.000 Q5SF07 IF2B2_MOUSE 7.00E-56 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) Igf2bp2 Imp2 Vickz2 Mus musculus (Mouse) TR41472_c0_g1_i3 0.005 0.000 0.000 2.136 1.784 0.000 Q5SF07 IF2B2_MOUSE 7.00E-56 GO:0005737; GO:0005856; GO:0003730; GO:0048027; GO:0051028; GO:0000166; GO:0005634; GO:0006417 cytoplasm; cytoskeleton; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA transport; nucleotide binding; nucleus; regulation of translation IPR004087; IPR004088; IPR012677; IPR000504; Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) Igf2bp2 Imp2 Vickz2 Mus musculus (Mouse) TR41486_c0_g1_i1 0.000 0.000 0.000 7.847 6.386 0.476 P70920 ACON_BRAJA 3.00E-54 GO:0051539; GO:0003994; GO:0046872; GO:0006099 "4 iron, 4 sulfur cluster binding; aconitate hydratase activity; metal ion binding; tricarboxylic acid cycle" IPR015931; IPR015937; IPR001030; IPR015928; IPR006249; IPR015934; IPR015932; IPR018136; IPR000573; Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. Aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) acnA bll0466 Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110) TR41510_c2_g1_i9 0.000 1.379 0.599 14.032 5.747 0.430 Q9DGQ7 CDC37_TETFL 3.00E-122 GO:0005737 cytoplasm IPR004918; IPR013873; IPR013874; IPR013855; Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) cdc37 Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis) TR41534_c0_g1_i11 0.000 0.181 0.531 6.279 1.248 0.017 Q81IE9 SYP2_BACCR 7.00E-134 GO:0005524; GO:0005737; GO:0004827; GO:0006433 ATP binding; cytoplasm; proline-tRNA ligase activity; prolyl-tRNA aminoacylation IPR002314; IPR006195; IPR004154; IPR002316; IPR004499; IPR016061; IPR017449; Proline--tRNA ligase 2 (EC 6.1.1.15) (Prolyl-tRNA synthetase 2) (ProRS 2) proS2 BC_0439 Bacillus cereus (strain ATCC 14579 / DSM 31) TR41536_c1_g2_i3 0.000 0.294 0.000 2.607 0.502 0.000 Q55GE6 ROCO7_DICDI 7.00E-25 GO:0005524; GO:0005096; GO:0005622; GO:0043547; GO:0004674; GO:0051056 ATP binding; GTPase activator activity; intracellular; positive regulation of GTPase activity; protein serine/threonine kinase activity; regulation of small GTPase mediated signal transduction IPR011009; IPR000719; IPR017441; IPR011047; IPR001936; IPR001245; IPR008271; IPR015943; IPR001680; IPR019775; Probable serine/threonine-protein kinase roco7 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 7) roco7 DDB_G0267472 Dictyostelium discoideum (Slime mold) TR41547_c0_g2_i7 0.368 0.137 0.866 5.335 1.129 0.000 P97449 AMPN_MOUSE 3.00E-99 GO:0004177; GO:0001525; GO:0030154; GO:0005793; GO:0009897; GO:0016021; GO:0008237; GO:0006508; GO:0008270 aminopeptidase activity; angiogenesis; cell differentiation; endoplasmic reticulum-Golgi intermediate compartment; external side of plasma membrane; integral to membrane; metallopeptidase activity; proteolysis; zinc ion binding IPR024571; IPR001930; IPR014782; Aminopeptidase N (AP-N) (mAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Membrane protein p161) (Microsomal aminopeptidase) (CD antigen CD13) Anpep Lap-1 Lap1 Mus musculus (Mouse) TR41558_c4_g1_i10 0.000 0.000 0.897 4.108 0.298 0.000 A4ZNR4 NKD2_DANRE 3.00E-18 GO:0016055; GO:0005509; GO:0005737; GO:0005886 Wnt receptor signaling pathway; calcium ion binding; cytoplasm; plasma membrane IPR011992; IPR018247; IPR002048; Protein naked cuticle homolog 2 (Naked-2) (Protein naked cuticle homolog 2-A) (Naked-2A) nkd2 nkd2a Danio rerio (Zebrafish) (Brachydanio rerio) TR41558_c4_g1_i7 0.000 0.000 0.000 1.990 0.171 0.177 Q2TJA6 NKD1_DANRE 4.00E-18 GO:0070121; GO:0060061; GO:0016055; GO:0005509; GO:0005737; GO:0060971; GO:0003146; GO:0090090; GO:0035414; GO:0001839; GO:0005886 Kupffer's vesicle development; Spemann organizer formation; Wnt receptor signaling pathway; calcium ion binding; cytoplasm; embryonic heart tube left/right pattern formation; heart jogging; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of catenin import into nucleus; neural plate morphogenesis; plasma membrane IPR011992; IPR018247; IPR002048; Protein naked cuticle homolog 1 (Naked-1) nkd1 Danio rerio (Zebrafish) (Brachydanio rerio) TR41591_c2_g1_i4 0.244 0.618 0.000 6.355 3.119 0.061 P41235 HNF4A_HUMAN 5.00E-176 GO:0001102; GO:0001077; GO:0003705; GO:0060395; GO:0007596; GO:0005737; GO:0031018; GO:0005504; GO:0042593; GO:0030522; GO:0004879; GO:0006629; GO:0030308; GO:0008285; GO:0005654; GO:0006591; GO:0055091; GO:2000189; GO:0042803; GO:0005102; GO:0010470; GO:0060398; GO:0050796; GO:0019216; GO:0009749; GO:0043565; GO:0007548; GO:0023019; GO:0003707; GO:0006367; GO:0044212; GO:0070328; GO:0006805; GO:0008270 Q99967; A8MYZ6 RNA polymerase II activating transcription factor binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; SMAD protein signal transduction; blood coagulation; cytoplasm; endocrine pancreas development; fatty acid binding; glucose homeostasis; intracellular receptor signaling pathway; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; lipid metabolic process; negative regulation of cell growth; negative regulation of cell proliferation; nucleoplasm; ornithine metabolic process; phospholipid homeostasis; positive regulation of cholesterol homeostasis; protein homodimerization activity; receptor binding; regulation of gastrulation; regulation of growth hormone receptor signaling pathway; regulation of insulin secretion; regulation of lipid metabolic process; response to glucose stimulus; sequence-specific DNA binding; sex differentiation; signal transduction involved in regulation of gene expression; steroid hormone receptor activity; transcription initiation from RNA polymerase II promoter; transcription regulatory region DNA binding; triglyceride homeostasis; xenobiotic metabolic process; zinc ion binding IPR003068; IPR008946; IPR000536; IPR001723; IPR001628; IPR013088; Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) HNF4A HNF4 NR2A1 TCF14 Homo sapiens (Human) TR41633_c0_g1_i4 30.488 29.301 52.415 223.954 198.772 0.000 Q14568 HS902_HUMAN 1.00E-114 GO:0005524; GO:0005737; GO:0006457; GO:0006950 ATP binding; cytoplasm; protein folding; response to stress IPR003594; IPR019805; IPR001404; IPR020575; IPR020568; Putative heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) HSP90AA2 HSPCAL3 Homo sapiens (Human) TR41721_c0_g3_i1 0.000 0.125 0.467 4.315 3.230 0.072 P54201 UBPA_DICDI 0 GO:0008234; GO:0008242; GO:0004221; GO:0006511; GO:0008270 cysteine-type peptidase activity; omega peptidase activity; ubiquitin thiolesterase activity; ubiquitin-dependent protein catabolic process; zinc ion binding IPR018200; IPR001394; IPR009060; IPR015940; IPR000449; IPR016652; IPR013083; IPR001607; Ubiquitin carboxyl-terminal hydrolase A (EC 3.4.19.12) (Deubiquitinating enzyme A) (Ubiquitin thioesterase A) (Ubiquitin-specific-processing protease A) ubpA usp5 DDB_G0291239 Dictyostelium discoideum (Slime mold) TR41724_c0_g1_i1 0.532 0.000 1.526 4.965 0.507 0.000 Q9P2Q2 FRM4A_HUMAN 4.00E-135 GO:0005737; GO:0005856; GO:0090162; GO:0005923 cytoplasm; cytoskeleton; establishment of epithelial cell polarity; tight junction IPR019749; IPR019750; IPR021774; IPR014352; IPR019748; IPR019747; IPR000299; IPR018979; IPR018980; IPR011993; FERM domain-containing protein 4A FRMD4A FRMD4 KIAA1294 Homo sapiens (Human) TR41727_c0_g1_i7 0.193 0.000 0.000 6.039 0.171 0.000 O95970 LGI1_HUMAN 3.00E-18 GO:0007411; GO:0030054; GO:0008283; GO:0005576; GO:0005615; GO:0030307; GO:0050806; GO:0051260; GO:0045202 axon guidance; cell junction; cell proliferation; extracellular region; extracellular space; positive regulation of cell growth; positive regulation of synaptic transmission; protein homooligomerization; synapse IPR000483; IPR009039; IPR005492; IPR003591; IPR000372; Leucine-rich glioma-inactivated protein 1 (Epitempin-1) LGI1 EPT UNQ775/PRO1569 Homo sapiens (Human) TR41728_c3_g1_i3 0.396 0.000 0.115 10.900 0.516 0.000 Q5SSZ5 TENS3_MOUSE 2.00E-107 GO:0016477; GO:0005925; GO:0048286; GO:0008284 cell migration; focal adhesion; lung alveolus development; positive regulation of cell proliferation IPR000008; IPR011993; IPR014019; IPR013625; IPR006020; IPR000980; IPR014020; Tensin-3 (Tensin-like SH2 domain-containing protein 1) Tns3 Tens1 Mus musculus (Mouse) TR41739_c1_g2_i13 2.600 0.880 2.984 9.733 1.733 0.000 P12370 KAPC_DROME 0 GO:0005524; GO:0007615; GO:0007448; GO:0048149; GO:0004691; GO:0005952; GO:0019933; GO:0048749; GO:0007480; GO:0007476; GO:0045475; GO:0045879; GO:0008355; GO:0007314; GO:0008103; GO:0005886; GO:0007228; GO:0008359; GO:0045187; GO:0007317; GO:0050804; GO:0040040 Q9VT65; Q03720 "ATP binding; anesthesia-resistant memory; anterior/posterior pattern specification, imaginal disc; behavioral response to ethanol; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase complex; cAMP-mediated signaling; compound eye development; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; locomotor rhythm; negative regulation of smoothened signaling pathway; olfactory learning; oocyte anterior/posterior axis specification; oocyte microtubule cytoskeleton polarization; plasma membrane; positive regulation of hh target transcription factor activity; regulation of bicoid mRNA localization; regulation of circadian sleep/wake cycle, sleep; regulation of pole plasm oskar mRNA localization; regulation of synaptic transmission; thermosensory behavior" IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; cAMP-dependent protein kinase catalytic subunit (PKA C) (EC 2.7.11.11) Pka-C1 CdkA DC0 CG4379 Drosophila melanogaster (Fruit fly) TR41739_c1_g2_i16 1.870 0.496 1.753 0.000 0.000 0.423 P12370 KAPC_DROME 0 GO:0005524; GO:0007615; GO:0007448; GO:0048149; GO:0004691; GO:0005952; GO:0019933; GO:0048749; GO:0007480; GO:0007476; GO:0045475; GO:0045879; GO:0008355; GO:0007314; GO:0008103; GO:0005886; GO:0007228; GO:0008359; GO:0045187; GO:0007317; GO:0050804; GO:0040040 Q9VT65; Q03720 "ATP binding; anesthesia-resistant memory; anterior/posterior pattern specification, imaginal disc; behavioral response to ethanol; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase complex; cAMP-mediated signaling; compound eye development; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; locomotor rhythm; negative regulation of smoothened signaling pathway; olfactory learning; oocyte anterior/posterior axis specification; oocyte microtubule cytoskeleton polarization; plasma membrane; positive regulation of hh target transcription factor activity; regulation of bicoid mRNA localization; regulation of circadian sleep/wake cycle, sleep; regulation of pole plasm oskar mRNA localization; regulation of synaptic transmission; thermosensory behavior" IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; cAMP-dependent protein kinase catalytic subunit (PKA C) (EC 2.7.11.11) Pka-C1 CdkA DC0 CG4379 Drosophila melanogaster (Fruit fly) TR41739_c1_g2_i2 0.018 0.385 0.000 5.053 0.281 0.000 P12370 KAPC_DROME 0 GO:0005524; GO:0007615; GO:0007448; GO:0048149; GO:0004691; GO:0005952; GO:0019933; GO:0048749; GO:0007480; GO:0007476; GO:0045475; GO:0045879; GO:0008355; GO:0007314; GO:0008103; GO:0005886; GO:0007228; GO:0008359; GO:0045187; GO:0007317; GO:0050804; GO:0040040 Q9VT65; Q03720 "ATP binding; anesthesia-resistant memory; anterior/posterior pattern specification, imaginal disc; behavioral response to ethanol; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase complex; cAMP-mediated signaling; compound eye development; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; locomotor rhythm; negative regulation of smoothened signaling pathway; olfactory learning; oocyte anterior/posterior axis specification; oocyte microtubule cytoskeleton polarization; plasma membrane; positive regulation of hh target transcription factor activity; regulation of bicoid mRNA localization; regulation of circadian sleep/wake cycle, sleep; regulation of pole plasm oskar mRNA localization; regulation of synaptic transmission; thermosensory behavior" IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; cAMP-dependent protein kinase catalytic subunit (PKA C) (EC 2.7.11.11) Pka-C1 CdkA DC0 CG4379 Drosophila melanogaster (Fruit fly) TR41739_c1_g2_i6 0.000 0.000 0.000 4.238 0.206 0.000 P12370 KAPC_DROME 0 GO:0005524; GO:0007615; GO:0007448; GO:0048149; GO:0004691; GO:0005952; GO:0019933; GO:0048749; GO:0007480; GO:0007476; GO:0045475; GO:0045879; GO:0008355; GO:0007314; GO:0008103; GO:0005886; GO:0007228; GO:0008359; GO:0045187; GO:0007317; GO:0050804; GO:0040040 Q9VT65; Q03720 "ATP binding; anesthesia-resistant memory; anterior/posterior pattern specification, imaginal disc; behavioral response to ethanol; cAMP-dependent protein kinase activity; cAMP-dependent protein kinase complex; cAMP-mediated signaling; compound eye development; imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; locomotor rhythm; negative regulation of smoothened signaling pathway; olfactory learning; oocyte anterior/posterior axis specification; oocyte microtubule cytoskeleton polarization; plasma membrane; positive regulation of hh target transcription factor activity; regulation of bicoid mRNA localization; regulation of circadian sleep/wake cycle, sleep; regulation of pole plasm oskar mRNA localization; regulation of synaptic transmission; thermosensory behavior" IPR000961; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; cAMP-dependent protein kinase catalytic subunit (PKA C) (EC 2.7.11.11) Pka-C1 CdkA DC0 CG4379 Drosophila melanogaster (Fruit fly) TR41745_c0_g2_i1 0.003 0.000 0.000 2.119 1.673 1.357 Q9ULT8 HECD1_HUMAN 0 GO:0005737; GO:0046872; GO:0001843; GO:0005634; GO:0042787; GO:0004842 cytoplasm; metal ion binding; neural tube closure; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR002110; IPR020683; IPR011989; IPR016024; IPR008979; IPR000569; IPR010606; IPR012919; Protein modification; protein ubiquitination. E3 ubiquitin-protein ligase HECTD1 (EC 6.3.2.-) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) HECTD1 KIAA1131 Homo sapiens (Human) TR41838_c2_g1_i1 0.021 0.127 0.346 5.266 0.485 0.000 P26009 ITA8_CHICK 3.00E-164 GO:0007155; GO:0030154; GO:0008305; GO:0007229; GO:0046872; GO:0007399 cell adhesion; cell differentiation; integrin complex; integrin-mediated signaling pathway; metal ion binding; nervous system development IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] ITGA8 Gallus gallus (Chicken) TR41838_c2_g1_i2 0.614 0.016 0.000 4.500 0.414 0.016 P26009 ITA8_CHICK 6.00E-165 GO:0007155; GO:0030154; GO:0008305; GO:0007229; GO:0046872; GO:0007399 cell adhesion; cell differentiation; integrin complex; integrin-mediated signaling pathway; metal ion binding; nervous system development IPR013517; IPR013519; IPR000413; IPR013649; IPR018184; Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] ITGA8 Gallus gallus (Chicken) TR41889_c0_g1_i2 1.317 0.043 0.485 10.334 0.740 0.000 Q05975 RAB2_LYMST 1.00E-133 GO:0005525; GO:0000139; GO:0005789; GO:0033116; GO:0015031; GO:0007264; GO:0016192 GTP binding; Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; protein transport; small GTPase mediated signal transduction; vesicle-mediated transport IPR027417; IPR005225; IPR001806; IPR003579; Ras-related protein Rab-2 RAB2 Lymnaea stagnalis (Great pond snail) TR41945_c6_g2_i1 0.323 0.337 0.318 3.466 0.392 0.000 Q00963 SPTCB_DROME 0 GO:0003779; GO:0051693; GO:0030506; GO:0016327; GO:0030424; GO:0016199; GO:0045169; GO:0045478; GO:0016328; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0005546; GO:0072499; GO:0007009; GO:0008091; GO:0045170; GO:0030721; GO:0005200 "actin binding; actin filament capping; ankyrin binding; apicolateral plasma membrane; axon; axon midline choice point recognition; fusome; fusome organization; lateral plasma membrane; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; phosphatidylinositol-4,5-bisphosphate binding; photoreceptor cell axon guidance; plasma membrane organization; spectrin; spectrosome; spectrosome organization; structural constituent of cytoskeleton" IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) TR41945_c6_g2_i5 0.001 0.121 0.000 5.376 0.104 0.131 Q00963 SPTCB_DROME 0 GO:0003779; GO:0051693; GO:0030506; GO:0016327; GO:0030424; GO:0016199; GO:0045169; GO:0045478; GO:0016328; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0005546; GO:0072499; GO:0007009; GO:0008091; GO:0045170; GO:0030721; GO:0005200 "actin binding; actin filament capping; ankyrin binding; apicolateral plasma membrane; axon; axon midline choice point recognition; fusome; fusome organization; lateral plasma membrane; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; phosphatidylinositol-4,5-bisphosphate binding; photoreceptor cell axon guidance; plasma membrane organization; spectrin; spectrosome; spectrosome organization; structural constituent of cytoskeleton" IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) TR41950_c0_g1_i1 2.555 0.753 2.195 6.032 1.216 0.000 Q09912 PSI1_SCHPO 2.00E-39 GO:0030544; GO:0007049; GO:0034605; GO:0002183; GO:0005829; GO:0005634; GO:0006457 Hsp70 protein binding; cell cycle; cellular response to heat; cytoplasmic translational initiation; cytosol; nucleus; protein folding IPR002939; IPR001623; IPR018253; IPR008971; Protein psi1 (Protein psi) psi1 psi SPCC830.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR41950_c0_g1_i6 0.000 0.067 1.446 7.940 1.190 0.000 Q9UDY4 DNJB4_HUMAN 1.00E-119 GO:0005737; GO:0005634; GO:0005886; GO:0006457; GO:0009408; GO:0006986; GO:0051082 cytoplasm; nucleus; plasma membrane; protein folding; response to heat; response to unfolded protein; unfolded protein binding IPR002939; IPR001623; IPR018253; IPR008971; DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein) DNAJB4 DNAJW HLJ1 Homo sapiens (Human) TR42002_c0_g1_i5 0.782 0.097 0.000 2.860 0.839 0.000 O95628 CNOT4_HUMAN 4.00E-130 GO:0003723; GO:0005829; GO:0000289; GO:0000166; GO:0005634; GO:0051865; GO:0004842; GO:0008270 RNA binding; cytosol; nuclear-transcribed mRNA poly(A) tail shortening; nucleotide binding; nucleus; protein autoubiquitination; ubiquitin-protein ligase activity; zinc ion binding IPR012677; IPR000504; IPR000571; IPR001841; IPR013083; Protein modification; protein ubiquitination. CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) CNOT4 NOT4 Homo sapiens (Human) TR42078_c1_g2_i6 0.052 0.509 0.028 27.943 6.373 0.085 O14302 CYK3_SCHPO 4.00E-09 GO:0005826; GO:0030428; GO:0051286; GO:0000281 actomyosin contractile ring; cell septum; cell tip; mitotic cytokinesis IPR001452; IPR002931; cytokinesis protein 3 cyk3 SPAC9G1.06c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42101_c0_g1_i7 0.000 0.480 0.000 2.346 1.311 0.175 Q9NZN5 ARHGC_HUMAN 2.00E-79 GO:0001664; GO:0007186; GO:0005096; GO:0005089; GO:0097190; GO:0007411; GO:0005829; GO:0016020; GO:0048011; GO:0005543; GO:0043547; GO:0043065; GO:0035023; GO:0051056; GO:0007264; GO:0038032 P08069; P61793; P61586 G-protein coupled receptor binding; G-protein coupled receptor signaling pathway; GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; apoptotic signaling pathway; axon guidance; cytosol; membrane; neurotrophin TRK receptor signaling pathway; phospholipid binding; positive regulation of GTPase activity; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; termination of G-protein coupled receptor signaling pathway IPR000219; IPR001331; IPR001478; IPR011993; IPR001849; IPR016137; IPR015212; IPR015721; Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) TR42115_c0_g2_i2 0.358 0.000 1.122 10.357 1.119 0.019 P14873 MAP1B_MOUSE 2.00E-85 GO:0048675; GO:0030054; GO:0005519; GO:0005829; GO:0016358; GO:0043197; GO:0061162; GO:0016787; GO:0005874; GO:0005875; GO:0001578; GO:0047497; GO:0032387; GO:0005886; GO:0045773; GO:0045202 Q9WTU3 axon extension; cell junction; cytoskeletal regulatory protein binding; cytosol; dendrite development; dendritic spine; establishment of monopolar cell polarity; hydrolase activity; microtubule; microtubule associated complex; microtubule bundle formation; mitochondrion transport along microtubule; negative regulation of intracellular transport; plasma membrane; positive regulation of axon extension; synapse IPR001279; IPR026074; IPR027321; IPR000102; Microtubule-associated protein 1B (MAP-1B) (MAP1(X)) (MAP1.2) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Map1b Mtap1b Mtap5 Mus musculus (Mouse) TR42121_c2_g1_i5 0.126 0.187 3.741 14.441 1.013 0.000 P32350 KNS1_YEAST 1.00E-70 GO:0005524; GO:0005737; GO:0016480; GO:0005634; GO:0046777; GO:0004674; GO:0004712; GO:0004713 ATP binding; cytoplasm; negative regulation of transcription from RNA polymerase III promoter; nucleus; protein autophosphorylation; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Dual specificity protein kinase KNS1 (EC 2.7.12.1) KNS1 YLL019C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42148_c0_g1_i3 0.000 0.000 0.000 2.666 0.057 0.000 P42262 GRIA2_HUMAN 2.00E-92 GO:0004971; GO:0032281; GO:0030054; GO:0030666; GO:0005789; GO:0005234; GO:0015277; GO:0045211; GO:0007268; GO:0008021 P46459 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; cell junction; endocytic vesicle membrane; endoplasmic reticulum membrane; extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; postsynaptic membrane; synaptic transmission; synaptic vesicle IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2)" GRIA2 GLUR2 Homo sapiens (Human) TR42148_c0_g1_i4 0.000 0.000 0.000 2.395 0.090 0.000 P42260 GRIK2_RAT 5.00E-121 GO:0030054; GO:0032839; GO:0005234; GO:0008328; GO:0015277; GO:0051967; GO:0051402; GO:0043204; GO:0043525; GO:0045211; GO:0042803; GO:0043113; GO:0046328; GO:0007268; GO:0043195 Q66HA1 "cell junction; dendrite cytoplasm; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor complex; kainate selective glutamate receptor activity; negative regulation of synaptic transmission, glutamatergic; neuron apoptotic process; perikaryon; positive regulation of neuron apoptotic process; postsynaptic membrane; protein homodimerization activity; receptor clustering; regulation of JNK cascade; synaptic transmission; terminal bouton" IPR001828; IPR019594; IPR001320; IPR001508; IPR028082; "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)" Grik2 Glur6 Rattus norvegicus (Rat) TR42160_c0_g1_i4 0.000 0.037 0.000 1.792 0.208 0.000 Q15652 JHD2C_HUMAN 1.00E-114 GO:0007596; GO:0016568; GO:0051213; GO:0046872; GO:0005654; GO:0006355; GO:0046966; GO:0006351 P10275 "blood coagulation; chromatin modification; dioxygenase activity; metal ion binding; nucleoplasm; regulation of transcription, DNA-dependent; thyroid hormone receptor binding; transcription, DNA-dependent" IPR003347; Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) JMJD1C JHDM2C KIAA1380 TRIP8 Homo sapiens (Human) TR42187_c0_g1_i4 0.000 16.035 0.572 13.333 10.692 0.007 Q9H987 SYP2L_HUMAN 2.00E-16 GO:0030018; GO:0005856; GO:0005634 Z disc; cytoskeleton; nucleus IPR001478; Synaptopodin 2-like protein SYNPO2L Homo sapiens (Human) TR42187_c0_g1_i5 0.000 0.000 10.912 0.000 0.000 0.000 A1ZA47 ZASP_DROME 6.00E-07 GO:0030018; GO:0015629; GO:0051371; GO:0005927; GO:0030239; GO:0001952; GO:0008270 Z disc; actin cytoskeleton; muscle alpha-actinin binding; muscle tendon junction; myofibril assembly; regulation of cell-matrix adhesion; zinc ion binding IPR001478; IPR006643; IPR001781; PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) TR42198_c2_g1_i1 1.993 5.025 2.137 5.296 4.822 0.000 A2VD00 EIF3A_XENLA 0 GO:0016282; GO:0033290; GO:0005852; GO:0001732; GO:0001731; GO:0006446; GO:0003743 eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; formation of translation initiation complex; formation of translation preinitiation complex; regulation of translational initiation; translation initiation factor activity IPR027512; IPR000717; Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) eif3a eif3s10 Xenopus laevis (African clawed frog) TR42234_c1_g1_i2 0.000 0.000 0.426 2.261 0.170 0.000 Q23356 MIG15_CAEEL 6.00E-171 GO:0005524; GO:0010171; GO:0033563; GO:0002119; GO:0004674; GO:0000003; GO:0004871; GO:0005083 ATP binding; body morphogenesis; dorsal/ventral axon guidance; nematode larval development; protein serine/threonine kinase activity; reproduction; signal transducer activity; small GTPase regulator activity IPR001180; IPR011009; IPR000719; IPR017441; IPR002290; IPR008271; Serine/threonine-protein kinase mig-15 (EC 2.7.11.1) (Abnormal cell migration protein 15) mig-15 ZC504.4 Caenorhabditis elegans TR42234_c1_g1_i3 0.850 0.351 0.000 4.125 0.593 0.432 Q99JP0 M4K3_MOUSE 8.00E-75 GO:0005524; GO:0007243; GO:0004674; GO:0009411; GO:0005083 Q13094; Q02111 ATP binding; intracellular protein kinase cascade; protein serine/threonine kinase activity; response to UV; small GTPase regulator activity IPR001180; IPR011009; IPR021160; IPR000719; IPR017441; IPR002290; Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) Map4k3 Mus musculus (Mouse) TR42236_c0_g1_i1 1.652 0.042 0.000 15.719 9.910 0.006 Q6NVU2 PPIG_XENTR 0 GO:0051301; GO:0032154; GO:0000777; GO:0005977; GO:0046872; GO:0030496; GO:0005739; GO:0007067; GO:0007084; GO:0016607; GO:0005730; GO:0006470; GO:0004722 cell division; cleavage furrow; condensed chromosome kinetochore; glycogen metabolic process; metal ion binding; midbody; mitochondrion; mitosis; mitotic nuclear envelope reassembly; nuclear speck; nucleolus; protein dephosphorylation; protein serine/threonine phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) ppp1cc TEgg061c20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) TR42236_c0_g1_i2 1.530 0.057 0.007 9.835 3.000 0.011 P23734 PP12_TRYBB 3.00E-138 GO:0046872; GO:0004721 metal ion binding; phosphoprotein phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1(5.9) (EC 3.1.3.16) Trypanosoma brucei brucei TR42236_c0_g1_i7 0.417 0.000 0.000 13.858 3.413 0.000 Q9LR78 BSU1_ARATH 4.00E-67 GO:0009742; GO:0005506; GO:0030145; GO:0005634; GO:0004722; GO:0032880 brassinosteroid mediated signaling pathway; iron ion binding; manganese ion binding; nucleus; protein serine/threonine phosphatase activity; regulation of protein localization IPR015916; IPR015915; IPR004843; IPR006186; IPR012391; Serine/threonine-protein phosphatase BSU1 (EC 3.1.3.16) (Bri1 suppressor protein 1) BSU1 At1g03445 At1g03450 F21B7.7 Arabidopsis thaliana (Mouse-ear cress) TR42249_c1_g2_i1 2.470 1.849 1.414 7.613 2.799 0.000 Q03049 YD541_YEAST 5.00E-39 GO:0004090; GO:0044237; GO:0050662 carbonyl reductase (NADPH) activity; cellular metabolic process; coenzyme binding IPR001509; IPR016040; Putative uncharacterized oxidoreductase YDR541C (EC 1.1.1.-) YDR541C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TR42260_c0_g1_i5 0.223 0.177 0.000 3.676 0.319 0.040 Q80XU8 LRFN4_MOUSE 5.00E-28 GO:0016021 integral to membrane IPR000483; IPR003961; IPR007110; IPR013783; IPR013098; IPR003598; IPR001611; IPR003591; IPR000372; Leucine-rich repeat and fibronectin type-III domain-containing protein 4 Lrfn4 Salm3 Mus musculus (Mouse) TR42261_c3_g2_i8 0.000 0.033 0.000 2.845 0.155 0.001 Q9JLI3 MMEL1_MOUSE 8.00E-168 GO:0005794; GO:0005783; GO:0005615; GO:0016021; GO:0004222; GO:0006508; GO:0008270 Golgi apparatus; endoplasmic reticulum; extracellular space; integral to membrane; metalloendopeptidase activity; proteolysis; zinc ion binding IPR024079; IPR000718; IPR018497; IPR008753; "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) (Neprilysin-like 1) (NL-1) (Neprilysin-like peptidase) (NEPLP) (Soluble secreted endopeptidase) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" Mmel1 Nep2 Nl1 Sep Mus musculus (Mouse) TR42305_c0_g1_i2 1.714 0.302 0.902 6.944 0.827 0.000 O55131 SEPT7_MOUSE 0 GO:0005525; GO:0043679; GO:0005938; GO:0051301; GO:0035085; GO:0060271; GO:0032154; GO:0000777; GO:0030496; GO:0007067; GO:0005634; GO:0051291; GO:0016476; GO:0031105; GO:0005819; GO:0001725; GO:0045202 GTP binding; axon terminus; cell cortex; cell division; cilium axoneme; cilium morphogenesis; cleavage furrow; condensed chromosome kinetochore; midbody; mitosis; nucleus; protein heterooligomerization; regulation of embryonic cell shape; septin complex; spindle; stress fiber; synapse IPR000038; IPR027417; IPR016491; IPR008115; Septin-7 (CDC10 protein homolog) Sept7 Cdc10 Mus musculus (Mouse) TR42313_c5_g1_i4 1.410 0.264 1.476 5.096 1.801 0.000 Q9ER30 KBTBA_RAT 9.00E-66 GO:0031463; GO:0031430; GO:0006928; GO:0005813; GO:0005856; GO:0030239; GO:0005730; GO:0005886; GO:0016567; GO:0031143; GO:0031275; GO:0045661; GO:2000291; GO:2001014; GO:0001726; GO:0035914 Cul3-RING ubiquitin ligase complex; M band; cellular component movement; centrosome; cytoskeleton; myofibril assembly; nucleolus; plasma membrane; protein ubiquitination; pseudopodium; regulation of lateral pseudopodium assembly; regulation of myoblast differentiation; regulation of myoblast proliferation; regulation of skeletal muscle cell differentiation; ruffle; skeletal muscle cell differentiation IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) Klhl41 Kbtbd10 Krp1 Rattus norvegicus (Rat) TR42313_c5_g1_i6 0.000 0.721 0.000 5.076 0.663 0.139 Q9ER30 KBTBA_RAT 3.00E-66 GO:0031463; GO:0031430; GO:0006928; GO:0005813; GO:0005856; GO:0030239; GO:0005730; GO:0005886; GO:0016567; GO:0031143; GO:0031275; GO:0045661; GO:2000291; GO:2001014; GO:0001726; GO:0035914 Cul3-RING ubiquitin ligase complex; M band; cellular component movement; centrosome; cytoskeleton; myofibril assembly; nucleolus; plasma membrane; protein ubiquitination; pseudopodium; regulation of lateral pseudopodium assembly; regulation of myoblast differentiation; regulation of myoblast proliferation; regulation of skeletal muscle cell differentiation; ruffle; skeletal muscle cell differentiation IPR011705; IPR000210; IPR011333; IPR013069; IPR017096; IPR015915; IPR006652; Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) Klhl41 Kbtbd10 Krp1 Rattus norvegicus (Rat) TR42333_c0_g2_i4 4.861 3.093 1.941 25.782 7.145 0.000 P55277 VATL_HELVI 4.00E-66 GO:0015991; GO:0015078; GO:0016021; GO:0033179; GO:0005774 "ATP hydrolysis coupled proton transport; hydrogen ion transmembrane transporter activity; integral to membrane; proton-transporting V-type ATPase, V0 domain; vacuolar membrane" IPR002379; IPR000245; IPR011555; V-type proton ATPase 16 kDa proteolipid subunit (V-ATPase 16 kDa proteolipid subunit) (Vacuolar proton pump 16 kDa proteolipid subunit) VHA16 Heliothis virescens (Tobacco budworm moth) TR42340_c0_g1_i3 0.000 1.134 0.000 8.271 0.698 0.000 Q6P3K7 KC1DB_DANRE 0 GO:0005524; GO:0016055; GO:0005737; GO:0005634; GO:0004674 ATP binding; Wnt receptor signaling pathway; cytoplasm; nucleus; protein serine/threonine kinase activity IPR011009; IPR000719; IPR017441; IPR008271; Casein kinase I isoform delta-B (CKI-delta-B) (CKId-B) (EC 2.7.11.1) csnk1db Danio rerio (Zebrafish) (Brachydanio rerio) TR42348_c0_g2_i3 0.083 0.031 0.000 2.352 0.252 0.012 P31650 S6A11_MOUSE 4.00E-108 GO:0007420; GO:0042995; GO:0005737; GO:0005332; GO:0005887; GO:0042165; GO:0005328; GO:0042493 brain development; cell projection; cytoplasm; gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter binding; neurotransmitter:sodium symporter activity; response to drug IPR000175; IPR002982; Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Sodium- and chloride-dependent GABA transporter 4) (GAT-4) (Solute carrier family 6 member 11) Slc6a11 Gabt3 Gabt4 Gat-4 Gat3 Gat4 Mus musculus (Mouse) TR42348_c0_g2_i6 0.000 0.000 0.000 4.661 0.000 0.000 Q9MZ34 SC6A6_BOVIN 3.00E-107 GO:0005887; GO:0005328; GO:0005369 integral to plasma membrane; neurotransmitter:sodium symporter activity; taurine:sodium symporter activity IPR000175; IPR002434; Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) SLC6A6 Bos taurus (Bovine) TR42348_c0_g2_i8 0.000 0.000 0.000 5.966 0.000 0.000 P31650 S6A11_MOUSE 4.00E-108 GO:0007420; GO:0042995; GO:0005737; GO:0005332; GO:0005887; GO:0042165; GO:0005328; GO:0042493 brain development; cell projection; cytoplasm; gamma-aminobutyric acid:sodium symporter activity; integral to plasma membrane; neurotransmitter binding; neurotransmitter:sodium symporter activity; response to drug IPR000175; IPR002982; Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Sodium- and chloride-dependent GABA transporter 4) (GAT-4) (Solute carrier family 6 member 11) Slc6a11 Gabt3 Gabt4 Gat-4 Gat3 Gat4 Mus musculus (Mouse) TR42414_c4_g1_i2 0.000 0.000 0.000 2.300 0.449 0.000 P40806 PKSJ_BACSU 9.00E-91 GO:0017000; GO:0005737; GO:0016874; GO:0031177; GO:0016746 "antibiotic biosynthetic process; cytoplasm; ligase activity; phosphopantetheine binding; transferase activity, transferring acyl groups" IPR010071; IPR009081; IPR025110; IPR020845; IPR000873; IPR001242; IPR018201; IPR014031; IPR014030; IPR016040; IPR020842; IPR020841; IPR020807; IPR013968; IPR020806; IPR006162; IPR016039; IPR016038; Antibiotic biosynthesis; bacillaene biosynthesis. Polyketide synthase PksJ (PKS) pksJ pksK BSU17180 Bacillus subtilis (strain 168) TR42423_c2_g3_i5 0.000 0.000 12.882 0.000 0.000 0.184 Q5XK91 FBCDB_XENLA 2.00E-47 GO:0008061; GO:0016021; GO:0046872 chitin binding; integral to membrane; metal ion binding IPR014716; IPR014715; IPR002181; IPR020837; Fibrinogen C domain-containing protein 1-B fibcd1-b Xenopus laevis (African clawed frog) TR42427_c2_g1_i5 0.165 0.109 0.000 1.540 0.130 0.010 P17972 KCNAW_DROME 0 GO:0005251; GO:0051260; GO:0030431; GO:0008076 delayed rectifier potassium channel activity; protein homooligomerization; sleep; voltage-gated potassium channel complex IPR000210; IPR011333; IPR027359; IPR005821; IPR003091; IPR003968; IPR003974; IPR015572; IPR003131; IPR028325; Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) TR42435_c0_g1_i4 0.318 0.134 0.000 5.214 0.345 0.050 P48487 PP1_BRAOL 4.00E-172 GO:0046872; GO:0004721 metal ion binding; phosphoprotein phosphatase activity IPR004843; IPR006186; Serine/threonine-protein phosphatase PP1 (EC 3.1.3.16) PP1 Brassica oleracea (Wild cabbage) TR42443_c3_g4_i10 0.654 0.112 0.000 4.696 1.174 0.095 Q9NUK0 MBNL3_HUMAN 5.00E-71 GO:0005794; GO:0008380; GO:0006397; GO:0046872; GO:0007275; GO:0045662; GO:0005634; GO:0043484 Golgi apparatus; RNA splicing; mRNA processing; metal ion binding; multicellular organismal development; negative regulation of myoblast differentiation; nucleus; regulation of RNA splicing IPR000571; Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR) MBNL3 CHCR MBLX39 MBXL Homo sapiens (Human) TR42448_c0_g1_i8 0.000 0.000 0.619 4.809 0.000 0.000 P96110 DHE3_THEMA 7.00E-79 GO:0006520; GO:0004353 cellular amino acid metabolic process; glutamate dehydrogenase [NAD(P)+] activity IPR006095; IPR006096; IPR006097; IPR014362; IPR016040; Glutamate dehydrogenase (GDH) (EC 1.4.1.3) gdhA gdh TM_1015 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) TR42487_c0_g1_i1 0.000 0.386 0.268 5.465 0.730 0.000 Q6P6Z8 ODO1_XENLA 0 GO:0006096; GO:0005759; GO:0004591; GO:0030976; GO:0006099 glycolysis; mitochondrial matrix; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; tricarboxylic acid cycle IPR011603; IPR001017; IPR005475; "2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)" ogdh Xenopus laevis (African clawed frog) TR42487_c0_g1_i8 0.583 0.540 0.104 6.874 0.998 0.000 Q6P6Z8 ODO1_XENLA 0 GO:0006096; GO:0005759; GO:0004591; GO:0030976; GO:0006099 glycolysis; mitochondrial matrix; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; tricarboxylic acid cycle IPR011603; IPR001017; IPR005475; "2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)" ogdh Xenopus laevis (African clawed frog) TR42501_c1_g1_i5 0.303 0.379 0.000 1.668 0.447 0.097 Q801X6 PHAR1_CHICK 7.00E-51 GO:0003779; GO:0031532; GO:0031032; GO:0030054; GO:0005829; GO:0005634; GO:0004864; GO:0043149; GO:0045202 actin binding; actin cytoskeleton reorganization; actomyosin structure organization; cell junction; cytosol; nucleus; protein phosphatase inhibitor activity; stress fiber assembly; synapse IPR004018; Phosphatase and actin regulator 1 PHACTR1 DDSG1 Gallus gallus (Chicken) TR42501_c1_g1_i7 0.000 0.000 0.000 1.538 0.117 0.017 Q801X6 PHAR1_CHICK 8.00E-51 GO:0003779; GO:0031532; GO:0031032; GO:0030054; GO:0005829; GO:0005634; GO:0004864; GO:0043149; GO:0045202 actin binding; actin cytoskeleton reorganization; actomyosin structure organization; cell junction; cytosol; nucleus; protein phosphatase inhibitor activity; stress fiber assembly; synapse IPR004018; Phosphatase and actin regulator 1 PHACTR1 DDSG1 Gallus gallus (Chicken) TR42506_c1_g1_i3 0.000 0.127 0.697 9.043 4.020 0.000 P35486 ODPA_MOUSE 4.00E-170 GO:0006086; GO:0006096; GO:0005759; GO:0005739; GO:0004739; GO:0004738; GO:0045254; GO:0006099 acetyl-CoA biosynthetic process from pyruvate; glycolysis; mitochondrial matrix; mitochondrion; pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase activity; pyruvate dehydrogenase complex; tricarboxylic acid cycle IPR001017; IPR017597; "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)" Pdha1 Pdha-1 Mus musculus (Mouse) TR42513_c1_g1_i5 5.179 3.835 1.900 5.281 12.470 0.002 Q5NVN8 RFOX1_PONAB 9.00E-42 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0000166; GO:0005634; GO:0043484 RNA binding; RNA splicing; cytoplasm; mRNA processing; nucleotide binding; nucleus; regulation of RNA splicing IPR025670; IPR012677; IPR017325; IPR000504; RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) RBFOX1 A2BP1 FOX1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) TR42513_c1_g1_i7 0.211 0.796 0.000 7.326 4.280 0.000 Q9JJ43 RFOX1_MOUSE 1.00E-40 GO:0003723; GO:0008380; GO:0005737; GO:0006397; GO:0050885; GO:0005654; GO:0000166; GO:0043484 RNA binding; RNA splicing; cytoplasm; mRNA processing; neuromuscular process controlling balance; nucleoplasm; nucleotide binding; regulation of RNA splicing IPR025670; IPR012677; IPR017325; IPR000504; RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) Rbfox1 A2bp A2bp1 Fox1 MNCb-3035 Mus musculus (Mouse) TR42518_c1_g1_i3 0.000 2.900 1.519 2.968 6.760 0.000 Q5EAJ7 MVP_STRPU 0 GO:0005737; GO:0005634; GO:0030529 cytoplasm; nucleus; ribonucleoprotein complex IPR000048; IPR021870; IPR002499; Major vault protein (MVP) MVP Strongylocentrotus purpuratus (Purple sea urchin) TR42523_c2_g1_i4 1.113 0.243 0.162 5.833 0.943 0.000 Q29HY3 CDC42_DROPS 2.00E-111 GO:0005525; GO:0005912; GO:0005622; GO:0045185; GO:0007275; GO:0005886; GO:0045860; GO:0007264 GTP binding; adherens junction; intracellular; maintenance of protein location; multicellular organismal development; plasma membrane; positive regulation of protein kinase activity; small GTPase mediated signal transduction IPR027417; IPR005225; IPR001806; IPR003578; Cdc42 homolog Cdc42 GA11680 Drosophila pseudoobscura pseudoobscura (Fruit fly) TR42524_c2_g2_i2 0.000 2.480 1.247 3.884 1.367 0.024 Q04861 NFKB1_CHICK 4.00E-19 GO:0002755; GO:0051059; GO:0035419; GO:0007250; GO:0005829; GO:0045087; GO:0001818; GO:0050728; GO:0045083; GO:0045892; GO:0005634; GO:0045944; GO:0043565; GO:0003700; GO:0035681; GO:0034134; GO:0035682; GO:0034138; GO:0034142; GO:0034146; GO:0034154; GO:0006351 "MyD88-dependent toll-like receptor signaling pathway; NF-kappaB binding; activation of MAPK activity involved in innate immune response; activation of NF-kappaB-inducing kinase activity; cytosol; innate immune response; negative regulation of cytokine production; negative regulation of inflammatory response; negative regulation of interleukin-12 biosynthetic process; negative regulation of transcription, DNA-dependent; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; toll-like receptor 15 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 21 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 7 signaling pathway; transcription, DNA-dependent" IPR002110; IPR020683; IPR011029; IPR000488; IPR013783; IPR014756; IPR002909; IPR000451; IPR008967; IPR011539; Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NFKB1 Gallus gallus (Chicken) TR42535_c0_g1_i6 0.000 0.065 0.000 2.267 0.080 0.000 O00339 MATN2_HUMAN 4.00E-26 GO:0007411; GO:0005604; GO:0005509; GO:0031104; GO:0008347; GO:0001764; GO:0005578; GO:0048678 O15265; O00555 axon guidance; basement membrane; calcium ion binding; dendrite regeneration; glial cell migration; neuron migration; proteinaceous extracellular matrix; response to axon injury IPR026823; IPR000742; IPR001881; IPR013032; IPR000152; IPR009030; IPR019466; IPR002035; Matrilin-2 MATN2 UNQ193/PRO219 Homo sapiens (Human) TR42542_c0_g2_i1 0.161 0.000 0.000 2.393 0.492 0.005 Q8N3T6 T132C_HUMAN 4.00E-61 GO:0016021 integral to membrane IPR026307; Transmembrane protein 132C TMEM132C Homo sapiens (Human) TR42548_c0_g2_i1 0.000 0.000 0.000 0.626 3.150 0.000 Q9CQ29 RN151_MOUSE 7.00E-09 GO:0030154; GO:0005737; GO:0005634; GO:0007283; GO:0004842; GO:0008270 cell differentiation; cytoplasm; nucleus; spermatogenesis; ubiquitin-protein ligase activity; zinc ion binding IPR013323; IPR008974; IPR001841; IPR013083; IPR017907; IPR013010; IPR001293; RING finger protein 151 Rnf151 Mus musculus (Mouse) TR42549_c2_g2_i2 0.179 0.226 0.000 1.758 1.104 0.079 P58751 RELN_RAT 0 GO:0030424; GO:0007411; GO:0007155; GO:0071549; GO:0021800; GO:0005737; GO:0030425; GO:0021542; GO:0005615; GO:0010001; GO:0021854; GO:0007626; GO:0007613; GO:0046872; GO:0007494; GO:0001764; GO:0021769; GO:0018108; GO:0043204; GO:0045860; GO:0051057; GO:0004712; GO:0005578; GO:0006508; GO:0043200; GO:0048678; GO:0051412; GO:0042493; GO:0051602; GO:0045471; GO:0070542; GO:0017085; GO:0010226; GO:0009612; GO:0048265; GO:0032570; GO:0008236; GO:0035176; GO:0021511 axon; axon guidance; cell adhesion; cellular response to dexamethasone stimulus; cerebral cortex tangential migration; cytoplasm; dendrite; dentate gyrus development; extracellular space; glial cell differentiation; hypothalamus development; locomotory behavior; memory; metal ion binding; midgut development; neuron migration; orbitofrontal cortex development; peptidyl-tyrosine phosphorylation; perikaryon; positive regulation of protein kinase activity; positive regulation of small GTPase mediated signal transduction; protein serine/threonine/tyrosine kinase activity; proteinaceous extracellular matrix; proteolysis; response to amino acid stimulus; response to axon injury; response to corticosterone stimulus; response to drug; response to electrical stimulus; response to ethanol; response to fatty acid; response to insecticide; response to lithium ion; response to mechanical stimulus; response to pain; response to progesterone stimulus; serine-type peptidase activity; social behavior; spinal cord patterning IPR000742; IPR013032; IPR002861; IPR011040; Reelin (EC 3.4.21.-) Reln Rattus norvegicus (Rat) TR42555_c2_g3_i2 116.588 35.779 17.191 0.115 0.226 90.903 Q9P544 VDAC_SCHPO 2.00E-38 GO:0005741; GO:0007005; GO:0046930; GO:0015288; GO:0008308 mitochondrial outer membrane; mitochondrion organization; pore complex; porin activity; voltage-gated anion channel activity IPR023614; IPR001925; IPR027246; Probable mitochondrial outer membrane protein porin SPAC1635.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) TR42586_c1_g1_i7 0.000 0.060 0.164 2.089 0.696 0.150 Q9WVR3 SHIP2_RAT 3.00E-173 GO:0005794; GO:0007015; GO:0007420; GO:0007155; GO:0005856; GO:0005829; GO:0001958; GO:0006897; GO:0030175; GO:0006006; GO:0032957; GO:0004445; GO:0030027; GO:0008156; GO:0043407; GO:0008285; GO:0010629; GO:0046627; GO:0043569; GO:0010977; GO:0010642; GO:0006661; GO:0046856; GO:0005547; GO:0005886; GO:0009791; GO:0042493; GO:0032868; GO:0097178 "Golgi apparatus; actin filament organization; brain development; cell adhesion; cytoskeleton; cytosol; endochondral ossification; endocytosis; filopodium; glucose metabolic process; inositol trisphosphate metabolic process; inositol-polyphosphate 5-phosphatase activity; lamellipodium; negative regulation of DNA replication; negative regulation of MAP kinase activity; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor signaling pathway; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-3,4,5-trisphosphate binding; plasma membrane; post-embryonic development; response to drug; response to insulin stimulus; ruffle assembly" IPR005135; IPR000300; IPR001660; IPR013761; IPR021129; IPR000980; "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)" Inppl1 Ship2 Rattus norvegicus (Rat) TR42592_c0_g5_i3 0.000 0.360 0.139 7.506 3.162 0.035 Q8K0C9 GMDS_MOUSE 0 GO:0042351; GO:0008446; GO:0019673; GO:0070401; GO:0007219; GO:0005622 "'de novo' GDP-L-fucose biosynthetic process; GDP-mannose 4,6-dehydratase activity; GDP-mannose metabolic process; NADP+ binding; Notch signaling pathway; intracellular" IPR001509; IPR006368; IPR016040; Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2. "GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)" Gmds Mus musculus (Mouse) TR42638_c1_g1_i6 0.010 0.000 0.472 7.486 0.923 0.029 O89053 COR1A_MOUSE 7.00E-172 GO:0043029; GO:0051015; GO:0007015; GO:0006816; GO:0031589; GO:0071353; GO:0030864; GO:0048873; GO:0042802; GO:0001772; GO:0030027; GO:0030595; GO:0051126; GO:0001891; GO:0045335; GO:0030670; GO:0001845; GO:0050918; GO:0042102; GO:0030335; GO:0043234; GO:0030833; GO:0008360; GO:0032796 T cell homeostasis; actin filament binding; actin filament organization; calcium ion transport; cell-substrate adhesion; cellular response to interleukin-4; cortical actin cytoskeleton; homeostasis of number of cells within a tissue; identical protein binding; immunological synapse; lamellipodium; leukocyte chemotaxis; negative regulation of actin nucleation; phagocytic cup; phagocytic vesicle; phagocytic vesicle membrane; phagolysosome assembly; positive chemotaxis; positive regulation of T cell proliferation; positive regulation of cell migration; protein complex; regulation of actin filament polymerization; regulation of cell shape; uropod organization IPR027333; IPR015505; IPR015048; IPR015049; IPR015943; IPR001680; IPR019775; IPR017986; Coronin-1A (Coronin-like protein A) (Clipin-A) (Coronin-like protein p57) (Tryptophan aspartate-containing coat protein) (TACO) Coro1a Coro1 Mus musculus (Mouse) TR42640_c0_g1_i2 0.451 0.389 0.001 1.555 0.377 0.000 Q6DCZ7 FBP1L_XENLA 2.00E-115 GO:0006914; GO:0005938; GO:0016023; GO:0005856; GO:0006897; GO:0008289; GO:0005886 autophagy; cell cortex; cytoplasmic membrane-bounded vesicle; cytoskeleton; endocytosis; lipid binding; plasma membrane IPR001060; IPR001452; Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) fnbp1l toca1 Xenopus laevis (African clawed frog) TR42655_c1_g3_i1 0.717 11.191 3.972 0.000 0.110 0.000 Q99MI9 ANM7_CRILO 6.00E-09 GO:0043046; GO:0016277; GO:0030154; GO:0005829; GO:0044020; GO:0005634; GO:0035243; GO:0006349; GO:0006355; GO:0000387; GO:0006351 "DNA methylation involved in gamete generation; [myelin basic protein]-arginine N-methyltransferase activity; cell differentiation; cytosol; histone methyltransferase activity (H4-R3 specific); nucleus; protein-arginine omega-N symmetric methyltransferase activity; regulation of gene expression by genetic imprinting; regulation of transcription, DNA-dependent; spliceosomal snRNP assembly; transcription, DNA-dependent" IPR025799; IPR025801; IPR014644; IPR010456; Protein arginine N-methyltransferase 7 (EC 2.1.1.-) (Histone-arginine N-methyltransferase PRMT7) (EC 2.1.1.125) ([Myelin basic protein]-arginine N-methyltransferase PRMT7) (EC 2.1.1.126) Prmt7 Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster) TR42661_c1_g1_i1 1.111 0.796 1.924 18.255 1.557 0.000 Q55ED1 NAP1_DICDI 9.00E-16 GO:0005737; GO:0042393; GO:0006334; GO:0005634 cytoplasm; histone binding; nucleosome assembly; nucleus IPR002164; Probable nucleosome assembly protein nap1 DDB_G0269290 Dictyostelium discoideum (Slime mold) TR42661_c1_g1_i13 0.130 0.000 0.000 4.401 0.136 0.000 A6NFF2 NP1L6_HUMAN 2.00E-10 GO:0006334; GO:0005634 nucleosome assembly; nucleus IPR002164; Putative nucleosome assembly protein 1-like 6 NAP1L6 Homo sapiens (Human) TR42661_c1_g1_i16 0.000 0.001 0.000 8.927 0.742 0.000 P28656 NP1L1_MOUSE 2.00E-116 GO:0042470; GO:0006334; GO:0005634 Q9WVS7 melanosome; nucleosome assembly; nucleus IPR002164; Nucleosome assembly protein 1-like 1 (Brain protein DN38) (NAP-1-related protein) Nap1l1 Nrp Mus musculus (Mouse) TR42669_c0_g2_i4 0.659 0.624 1.660 4.732 0.650 0.000 P15170 ERF3A_HUMAN 0 GO:0000082; GO:0005525; GO:0003924; GO:0005622; GO:0000184; GO:0006479; GO:0003747 P62495; Q92900 "G1/S transition of mitotic cell cycle; GTP binding; GTPase activity; intracellular; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein methylation; translation release factor activity" IPR000795; IPR027417; IPR009000; IPR009001; IPR004161; IPR004160; Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (G1 to S phase transition protein 1 homolog) GSPT1 ERF3A Homo sapiens (Human) TR42676_c0_g2_i1 0.000 0.000 0.000 2.221 1.914 0.000 Q54YD4 SYIC_DICDI 0 GO:0005524; GO:0002161; GO:0005829; GO:0004822; GO:0006428; GO:0006450 ATP binding; aminoacyl-tRNA editing activity; cytosol; isoleucine-tRNA ligase activity; isoleucyl-tRNA aminoacylation; regulation of translational fidelity IPR001412; IPR002300; IPR002301; IPR023586; IPR014729; IPR009080; IPR013155; IPR009008; "Probable isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)" ileS DDB_G0278293 Dictyostelium discoideum (Slime mold) TR42687_c3_g2_i4 0.000 0.000 0.287 3.186 0.189 0.077 P21613 KINH_LOLPE 0 GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0003777; GO:0007018 ATP binding; cytoplasm; kinesin complex; microtubule; microtubule motor activity; microtubule-based movement IPR027640; IPR019821; IPR001752; IPR027417; Kinesin heavy chain Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) TR42714_c0_g1_i1 1.803 0.000 1.208 3.206 1.379 0.000 Q7Z6Z7 HUWE1_HUMAN 0 GO:0003677; GO:0006284; GO:0030154; GO:0005737; GO:0016574; GO:0005634; GO:0006513; GO:0000209; GO:0042787; GO:0004842 Q8N726; P04637; Q13107 DNA binding; base-excision repair; cell differentiation; cytoplasm; histone ubiquitination; nucleus; protein monoubiquitination; protein polyubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ubiquitin-protein ligase activity IPR016024; IPR025527; IPR010309; IPR010314; IPR000569; IPR009060; IPR015940; IPR000449; IPR004170; Protein modification; protein ubiquitination. "E3 ubiquitin-protein ligase HUWE1 (EC 6.3.2.-) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)" HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272 Homo sapiens (Human) TR42723_c0_g1_i2 0.005 0.000 1.824 0.000 0.149 0.000 Q9EPU0 RENT1_MOUSE 0 GO:0005524; GO:0004004; GO:0003677; GO:0006281; GO:0006260; GO:0003723; GO:0000785; GO:0003682; GO:0000932; GO:0009048; GO:0071044; GO:0000184; GO:0005634; GO:0006449; GO:0008270 "ATP binding; ATP-dependent RNA helicase activity; DNA binding; DNA repair; DNA replication; RNA binding; chromatin; chromatin binding; cytoplasmic mRNA processing body; dosage compensation by inactivation of X chromosome; histone mRNA catabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; regulation of translational termination; zinc ion binding" IPR027417; IPR018999; Regulator of nonsense transcripts 1 (EC 3.6.4.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (mUpf1) Upf1 Rent1 Mus musculus (Mouse) TR42730_c0_g1_i1 0.000 0.494 0.740 4.278 1.028 0.047 Q03601 NHL1_CAEEL 7.00E-82 GO:0008270 G5EFS1; O62482 zinc ion binding IPR011042; IPR001258; IPR013017; IPR018957; IPR001841; IPR013083; IPR017907; RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans TR42730_c0_g1_i9 0.000 0.067 0.000 2.740 0.451 0.000 Q03601 NHL1_CAEEL 1.00E-82 GO:0008270 G5EFS1; O62482 zinc ion binding IPR011042; IPR001258; IPR013017; IPR018957; IPR001841; IPR013083; IPR017907; RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans TR42740_c1_g1_i1 1.011 0.953 0.470 11.108 2.474 0.000 Q7ZW47 STAU2_DANRE 2.00E-125 GO:0003723; GO:0005874; GO:0006810 RNA binding; microtubule; transport IPR014720; Double-stranded RNA-binding protein Staufen homolog 2 stau2 zgc:55287 Danio rerio (Zebrafish) (Brachydanio rerio) TR42740_c1_g1_i2 3.436 2.012 1.549 11.468 6.797 0.000 Q9Z108 STAU1_MOUSE 2.00E-60 GO:0003723; GO:0010494; GO:0008298; GO:0005791 RNA binding; cytoplasmic stress granule; intracellular mRNA localization; rough endoplasmic reticulum IPR014720; Double-stranded RNA-binding protein Staufen homolog 1 Stau1 Stau Mus musculus (Mouse) TR42740_c1_g1_i3 0.000 0.026 1.400 3.398 1.034 0.000 P25159 STAU_DROME 1.00E-29 GO:0045179; GO:0016324; GO:0055059; GO:0045167; GO:0045180; GO:0009925; GO:0045450; GO:0000932; GO:0003725; GO:0060293; GO:0007616; GO:0003730; GO:0005875; GO:0008017; GO:0007017; GO:0007400; GO:0045451; GO:0007318; GO:0010606; GO:0046012; GO:0007317 apical cortex; apical plasma membrane; asymmetric neuroblast division; asymmetric protein localization involved in cell fate determination; basal cortex; basal plasma membrane; bicoid mRNA localization; cytoplasmic mRNA processing body; double-stranded RNA binding; germ plasm; long-term memory; mRNA 3'-UTR binding; microtubule associated complex; microtubule binding; microtubule-based process; neuroblast fate determination; pole plasm oskar mRNA localization; pole plasm protein localization; positive regulation of cytoplasmic mRNA processing body assembly; positive regulation of oskar mRNA translation; regulation of pole plasm oskar mRNA localization IPR014720; Maternal effect protein staufen stau CG5753 Drosophila melanogaster (Fruit fly) TR42799_c0_g1_i1 1.681 1.197 0.000 3.117 0.615 2.150 Q9VT65 CANB_DROME 0 GO:0007298; GO:0005509; GO:0004198; GO:0005737; GO:0016020; GO:0016540; GO:0006508 P12370 border follicle cell migration; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cytoplasm; membrane; protein autoprocessing; proteolysis IPR022684; IPR022682; IPR022683; IPR011992; IPR018247; IPR002048; IPR000169; IPR001300; Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2] CalpB CG8107 Drosophila melanogaster (Fruit fly) TR42847_c1_g3_i2 0.567 0.077 0.092 26.624 0.740 0.000 Q76LL6 FHOD3_MOUSE 6.00E-113 GO:0030018; GO:0051639; GO:0007015; GO:0005856; GO:0030837; GO:0030017; GO:0045214 Z disc; actin filament network formation; actin filament organization; cytoskeleton; negative regulation of actin filament polymerization; sarcomere; sarcomere organization IPR016024; IPR014767; IPR015425; IPR027651; IPR014768; FH1/FH2 domain-containing protein 3 (Formin homolog overexpressed in spleen 2) (mFHOS2) Fhod3 Fhos2 Kiaa1695 Mus musculus (Mouse) TR42906_c0_g1_i5 0.017 0.054 0.000 4.362 0.263 0.000 P31421 GRM2_RAT 1.00E-23 GO:0030424; GO:0005246; GO:0030054; GO:0030425; GO:0014047; GO:0001641; GO:0005887; GO:0005622; GO:0042734; GO:0046928; GO:0051966 P14842; Q96S59 "axon; calcium channel regulator activity; cell junction; dendrite; glutamate secretion; group II metabotropic glutamate receptor activity; integral to plasma membrane; intracellular; presynaptic membrane; regulation of neurotransmitter secretion; regulation of synaptic transmission, glutamatergic" IPR001828; IPR000337; IPR011500; IPR017978; IPR017979; IPR000162; IPR001458; IPR028082; Metabotropic glutamate receptor 2 (mGluR2) Grm2 Gprc1b Mglur2 Rattus norvegicus (Rat) TR42939_c0_g1_i1 0.000 0.000 0.000 4.038 0.128 0.000 Q00963 SPTCB_DROME 4.00E-128 GO:0003779; GO:0051693; GO:0030506; GO:0016327; GO:0030424; GO:0016199; GO:0045169; GO:0045478; GO:0016328; GO:0005811; GO:0042062; GO:0048790; GO:0008017; GO:0007026; GO:0031594; GO:0007274; GO:0005546; GO:0072499; GO:0007009; GO:0008091; GO:0045170; GO:0030721; GO:0005200 "actin binding; actin filament capping; ankyrin binding; apicolateral plasma membrane; axon; axon midline choice point recognition; fusome; fusome organization; lateral plasma membrane; lipid particle; long-term strengthening of neuromuscular junction; maintenance of presynaptic active zone structure; microtubule binding; negative regulation of microtubule depolymerization; neuromuscular junction; neuromuscular synaptic transmission; phosphatidylinositol-4,5-bisphosphate binding; photoreceptor cell axon guidance; plasma membrane organization; spectrin; spectrosome; spectrosome organization; structural constituent of cytoskeleton" IPR001589; IPR001715; IPR001605; IPR011993; IPR001849; IPR018159; IPR016343; IPR002017; Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) TR42939_c0_g2_i6 0.766 0.524 0.000 15.703 3.639 0.000 Q13813 SPTN1_HUMAN 0 GO:0030018; GO:0003779; GO:0051693; GO:0007411; GO:0005509; GO:0006921; GO:0032437; GO:0005829; GO:0005916; GO:0043231; GO:0016328; GO:0016020; GO:0015630; GO:0008091; GO:0005200 Q9UI08; O15287; P40692; Q01082 Z disc; actin binding; actin filament capping; axon guidance; calcium ion binding; cellular component disassembly involved in execution phase of apoptosis; cuticular plate; cytosol; fascia adherens; intracellular membrane-bounded organelle; lateral plasma membrane; membrane; microtubule cytoskeleton; spectrin; structural constituent of cytoskeleton IPR011992; IPR014837; IPR018247; IPR002048; IPR001452; IPR018159; IPR013315; IPR002017; "Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)" SPTAN1 NEAS SPTA2 Homo sapiens (Human) TR42942_c0_g1_i4 0.000 0.217 0.431 2.354 0.491 0.143 Q14738 2A5D_HUMAN 0 GO:0002755; GO:0035666; GO:0005829; GO:0006112; GO:0006096; GO:0045087; GO:0007399; GO:0048011; GO:0005654; GO:0000159; GO:0008601; GO:0004722; GO:0044281; GO:0051403; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124 O08785; Q13136; P30153; P30154 MyD88-dependent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cytosol; energy reserve metabolic process; glycolysis; innate immune response; nervous system development; neurotrophin TRK receptor signaling pathway; nucleoplasm; protein phosphatase type 2A complex; protein phosphatase type 2A regulator activity; protein serine/threonine phosphatase activity; small molecule metabolic process; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor TLR1:TLR2 signaling pathway; toll-like receptor TLR6:TLR2 signaling pathway IPR016024; IPR002554; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) PPP2R5D Homo sapiens (Human) TR42983_c3_g1_i4 1.353 1.674 0.000 8.444 1.005 0.000 Q68FR8 TBA3_RAT 0 GO:0005525; GO:0003924; GO:0005737; GO:0005874; GO:0007017; GO:0051258; GO:0005200 GTP binding; GTPase activity; cytoplasm; microtubule; microtubule-based process; protein polymerization; structural constituent of cytoskeleton IPR002452; IPR008280; IPR000217; IPR018316; IPR023123; IPR017975; IPR003008; Tubulin alpha-3 chain (Alpha-tubulin 3) Tuba3a Tuba3; Tuba3b Tuba3 Rattus norvegicus (Rat) TR43012_c1_g1_i1 30.001 20.043 0.016 0.019 0.029 10.198 P41366 VMO1_CHICK 2.00E-16 GO:0005576; GO:0030704 extracellular region; vitelline membrane formation IPR005515; Vitelline membrane outer layer protein 1 (VMO-1) (VMO-I) (VMOI) VMO1 Gallus gallus (Chicken) TR43012_c2_g1_i3 0.000 7.646 10.840 4.122 2.185 2.910 P10155 RO60_HUMAN 3.00E-114 GO:0003723; GO:0060271; GO:0005737; GO:0046872; GO:0005634; GO:0030529; GO:0006383 Q9UHX1 RNA binding; cilium morphogenesis; cytoplasm; metal ion binding; nucleus; ribonucleoprotein complex; transcription from RNA polymerase III promoter IPR008858; IPR018698; 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) TR43033_c3_g2_i12 0.000 0.000 0.001 8.665 4.723 0.000 Q92125 ANXA7_XENLA 4.00E-110 GO:0005509; GO:0005544 calcium ion binding; calcium-dependent phospholipid binding IPR001464; IPR018502; IPR018252; IPR013286; Annexin A7 (Annexin VII) (Annexin-7) (Synexin) anxa7 anx7 Xenopus laevis (African clawed frog) TR43033_c3_g2_i6 9.379 3.080 4.121 0.000 0.000 0.551 Q9SYT0 ANXD1_ARATH 1.00E-47 GO:0005524; GO:0048046; GO:0005509; GO:0070588; GO:0005544; GO:0005618; GO:0009570; GO:0005507; GO:0005829; GO:0005739; GO:0004601; GO:0005886; GO:0009506; GO:0071435; GO:0042803; GO:0009737; GO:0046686; GO:0009409; GO:0009408; GO:0006979; GO:0009651; GO:0009414; GO:0009579; GO:0005774; GO:0008270 ATP binding; apoplast; calcium ion binding; calcium ion transmembrane transport; calcium-dependent phospholipid binding; cell wall; chloroplast stroma; copper ion binding; cytosol; mitochondrion; peroxidase activity; plasma membrane; plasmodesma; potassium ion export; protein homodimerization activity; response to abscisic acid stimulus; response to cadmium ion; response to cold; response to heat; response to oxidative stress; response to salt stress; response to water deprivation; thylakoid; vacuolar membrane; zinc ion binding IPR001464; IPR009118; IPR018502; IPR018252; Annexin D1 (AnnAt1) (Annexin A1) ANN1 ANNAT1 ANX23-ATH ATOXY5 OXY5 At1g35720 F14D7.2 Arabidopsis thaliana (Mouse-ear cress) TR43038_c0_g1_i6 0.000 0.640 0.002 6.241 1.342 0.033 Q63372 NRX1A_RAT 3.00E-91 GO:0033130; GO:0030534; GO:0005246; GO:0005509; GO:0007155; GO:0050839; GO:0030054; GO:0009986; GO:0097116; GO:0016021; GO:0007612; GO:0097118; GO:0097109; GO:0050885; GO:0007269; GO:2000463; GO:0051965; GO:0090129; GO:0051968; GO:0097119; GO:0097104; GO:0060134; GO:0042734; GO:0051290; GO:2000821 "acetylcholine receptor binding; adult behavior; calcium channel regulator activity; calcium ion binding; cell adhesion; cell adhesion molecule binding; cell junction; cell surface; gephyrin clustering; integral to membrane; learning; neuroligin clustering; neuroligin family protein binding; neuromuscular process controlling balance; neurotransmitter secretion; positive regulation of excitatory postsynaptic membrane potential; positive regulation of synapse assembly; positive regulation of synapse maturation; positive regulation of synaptic transmission, glutamatergic; postsynaptic density protein 95 clustering; postsynaptic membrane assembly; prepulse inhibition; presynaptic membrane; protein heterotetramerization; regulation of grooming behavior" IPR008985; IPR013320; IPR000742; IPR000152; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) Nrxn1 Rattus norvegicus (Rat) TR43038_c0_g1_i7 0.190 0.081 0.000 13.790 3.110 0.033 A1XQX0 NR1AA_DANRE 2.00E-93 GO:0007155; GO:0016021; GO:0046872; GO:0007269; GO:0051965; GO:0090129; GO:0007416 cell adhesion; integral to membrane; metal ion binding; neurotransmitter secretion; positive regulation of synapse assembly; positive regulation of synapse maturation; synapse assembly IPR008985; IPR013320; IPR000742; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1a (Neurexin Ia-alpha) (Neurexin-1a-alpha) nrxn1a Danio rerio (Zebrafish) (Brachydanio rerio) TR43038_c0_g1_i8 0.868 0.604 1.352 0.000 0.018 0.004 A1XQX0 NR1AA_DANRE 2.00E-93 GO:0007155; GO:0016021; GO:0046872; GO:0007269; GO:0051965; GO:0090129; GO:0007416 cell adhesion; integral to membrane; metal ion binding; neurotransmitter secretion; positive regulation of synapse assembly; positive regulation of synapse maturation; synapse assembly IPR008985; IPR013320; IPR000742; IPR001791; IPR003585; IPR027158; IPR027789; Neurexin-1a (Neurexin Ia-alpha) (Neurexin-1a-alpha) nrxn1a Danio rerio (Zebrafish) (Brachydanio rerio) TR43040_c0_g1_i7 0.000 0.000 0.000 5.137 0.356 0.000 Q9U9K0 ADD1_CAEEL 3.00E-141 GO:0051015; GO:0051016; GO:0005737; GO:0007616; GO:0005886; GO:0014069; GO:0097120; GO:2000249; GO:0007614 actin filament binding; barbed-end actin filament capping; cytoplasm; long-term memory; plasma membrane; postsynaptic density; receptor localization to synapse; regulation of actin cytoskeleton reorganization; short-term memory IPR001303; Adducin-related protein 1 add-1 F39C12.2 Caenorhabditis elegans TR43046_c0_g1_i1 0.000 0.000 0.000 11.570 0.021 0.283 Q66403 DPOL_DHBVQ 5.00E-06 GO:0003677; GO:0003887; GO:0003723; GO:0006278; GO:0003964; GO:0046872; GO:0090305; GO:0004523 DNA binding; DNA-directed DNA polymerase activity; RNA binding; RNA-dependent DNA replication; RNA-directed DNA polymerase activity; metal ion binding; nucleic acid phosphodiester bond hydrolysis; ribonuclease H activity IPR001462; IPR000201; IPR000477; Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] P Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) TR43046_c0_g1_i2 0.000 1.889 0.000 7.218 1.363 0.209 O50655 XERD_SELRU 9.00E-09 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR43046_c0_g1_i4 1.061 3.225 2.056 32.179 9.581 0.000 O50655 XERD_SELRU 9.00E-09 GO:0003677; GO:0015074; GO:0006310; GO:0075713; GO:0046718 DNA binding; DNA integration; DNA recombination; establishment of integrated proviral latency; viral entry into host cell IPR011010; IPR013762; IPR002104; IPR010998; IPR023109; Integrase/recombinase xerD homolog xerD Selenomonas ruminantium TR43074_c0_g2_i4 0.007 2.056 3.477 18.112 2.671 1.119 Q99JZ0 SDCB2_MOUSE 3.00E-95 GO:0005737; GO:0008022; GO:0046982; GO:0042803 cytoplasm; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity IPR001478; Syntenin-2 (Syndecan-binding protein 2) Sdcbp2 Mus musculus (Mouse) TR43095_c0_g1_i8 0.001 0.293 0.001 1.237 0.000 0.001 Q7YSI9 UNC53_CAEEL 3.00E-51 GO:0030036; GO:0051015; GO:0007411; GO:0043057; GO:0005737; GO:0016204; GO:0007617; GO:0008078; GO:0018991; GO:0045773; GO:0030335; GO:0040018; GO:0007165 actin cytoskeleton organization; actin filament binding; axon guidance; backward locomotion; cytoplasm; determination of muscle attachment site; mating behavior; mesodermal cell migration; oviposition; positive regulation of axon extension; positive regulation of cell migration; positive regulation of multicellular organism growth; signal transduction IPR001715; IPR027417; Adapter protein unc-53 (Uncoordinated protein 53) unc-53 F45E10.1 Caenorhabditis elegans TR43104_c0_g1_i8 0.000 0.000 0.000 3.051 0.097 0.000 P11046 LAMB1_DROME 8.00E-114 GO:0005605; GO:0070831; GO:0007155; GO:0016477; GO:0050829; GO:0008406; GO:0045089 basal lamina; basement membrane assembly; cell adhesion; cell migration; defense response to Gram-negative bacterium; gonad development; positive regulation of innate immune response IPR013032; IPR002049; IPR013015; IPR008211; Laminin subunit beta-1 (Laminin B1 chain) LanB1 lamB1 CG7123 Drosophila melanogaster (Fruit fly) TR43104_c0_g2_i3 0.223 0.027 0.000 2.570 0.160 0.000 P07942 LAMB1_HUMAN 0 GO:0007411; GO:0007566; GO:0030198; GO:0005201; GO:0005615; GO:0070062; GO:0043208; GO:0005606; GO:0043259; GO:0005607; GO:0043257; GO:0007162; GO:0021812; GO:0042476; GO:0048471; GO:0030335; GO:0050679; GO:0034446 axon guidance; embryo implantation; extracellular matrix organization; extracellular matrix structural constituent; extracellular space; extracellular vesicular exosome; glycosphingolipid binding; laminin-1 complex; laminin-10 complex; laminin-2 complex; laminin-8 complex; negative regulation of cell adhesion; neuronal-glial interaction involved in cerebral cortex radial glia guided migration; odontogenesis; perinuclear region of cytoplasm; positive regulation of cell migration; positive regulation of epithelial cell proliferation; substrate adhesion-dependent cell spreading IPR002049; IPR013015; IPR008211; IPR009053; Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) LAMB1 Homo sapiens (Human) TR43115_c2_g1_i4 0.250 1.257 0.000 5.973 4.076 0.000 Q8MY85 FGFR2_DUGJA 1.00E-47 GO:0005524; GO:0016021; GO:0018108; GO:0004714 ATP binding; integral to membrane; peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase activity IPR007110; IPR013783; IPR011009; IPR000719; IPR017441; IPR001245; IPR008266; IPR020635; Fibroblast growth factor receptor 2 (DjFgfr2) (FGFR-2) (EC 2.7.10.1) (DjPTK1) FGFR2 Dugesia japonica (Planarian) TR43133_c1_g1_i2 3.645 0.000 5.175 9.720 1.834 0.929 Q9U943 APLP_LOCMI 3.00E-60 GO:0016055; GO:0005576; GO:0008289; GO:0005319 Wnt receptor signaling pathway; extracellular region; lipid binding; lipid transporter activity IPR015819; IPR001747; IPR009454; IPR015816; IPR015255; IPR015817; IPR015818; IPR011030; IPR001846; Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] Locusta migratoria (Migratory locust) TR43136_c0_g1_i3 5.760 1.021 0.038 189.012 3.910 0.122 P32018 COEA1_CHICK 1.00E-07 GO:0007155; GO:0005581 cell adhesion; collagen IPR008160; IPR008985; IPR003961; IPR013783; IPR001791; IPR002035; Collagen alpha-1(XIV) chain (Undulin) COL14A1 Gallus gallus (Chicken) TR43139_c1_g1_i3 0.079 0.718 0.000 2.916 2.778 0.000 Q9UGM3 DMBT1_HUMAN 1.00E-132 GO:0048306; GO:0051607; GO:0030855; GO:0005576; GO:0019898; GO:0043152; GO:0045087; GO:0001833; GO:0019048; GO:0030670; GO:0030858; GO:0015031; GO:0005578; GO:0005044; GO:0008329; GO:0035375; GO:0042589 calcium-dependent protein binding; defense response to virus; epithelial cell differentiation; extracellular region; extrinsic to membrane; induction of bacterial agglutination; innate immune response; inner cell mass cell proliferation; modulation by virus of host morphology or physiology; phagocytic vesicle membrane; positive regulation of epithelial cell differentiation; protein transport; proteinaceous extracellular matrix; scavenger receptor activity; signaling pattern recognition receptor activity; zymogen binding; zymogen granule membrane IPR000859; IPR001190; IPR017448; IPR001507; IPR017977; Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) TR43183_c0_g1_i4 0.000 0.000 0.358 72.133 5.246 0.017 Q86TC9 MYPN_HUMAN 9.00E-17 GO:0031674; GO:0030018; GO:0015630; GO:0005634; GO:0045214 P20929 I band; Z disc; microtubule cytoskeleton; nucleus; sarcomere organization IPR007110; IPR013783; IPR013098; IPR003598; Myopalladin (145 kDa sarcomeric protein) MYPN MYOP Homo sapiens (Human) TR43236_c1_g1_i4 0.000 0.037 0.000 3.317 0.217 0.024 Q8K009 AL1L2_MOUSE 0 GO:0009258; GO:0009058; GO:0016155; GO:0016742; GO:0032259; GO:0008168; GO:0005739; GO:0006730; GO:0016620 "10-formyltetrahydrofolate catabolic process; biosynthetic process; formyltetrahydrofolate dehydrogenase activity; hydroxymethyl-, formyl- and related transferase activity; methylation; methyltransferase activity; mitochondrion; one-carbon metabolic process; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" IPR011407; IPR009081; IPR016161; IPR016163; IPR016160; IPR016162; IPR015590; IPR005793; IPR002376; IPR011034; IPR001555; IPR006162; Mitochondrial 10-formyltetrahydrofolate dehydrogenase (Mitochondrial 10-FTHFDH) (mtFDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L2) Aldh1l2 Mus musculus (Mouse) TR43237_c0_g1_i4 0.257 0.327 0.000 3.171 0.640 0.225 Q07130 UGPA_BOVIN 0 GO:0003983; GO:0005737; GO:0046872 UTP:glucose-1-phosphate uridylyltransferase activity; cytoplasm; metal ion binding IPR002618; IPR016267; UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) UGP2 Bos taurus (Bovine) TR43238_c1_g1_i2 0.636 0.000 2.274 24.107 0.929 0.057 Q8N9C0 IGS22_HUMAN 5.00E-25 IPR003961; IPR007110; IPR013783; IPR013098; IPR003599; Immunoglobulin superfamily member 22 (IgSF22) IGSF22 Homo sapiens (Human) TR43241_c4_g2_i2 0.000 0.220 0.419 2.956 0.711 0.148 Q8K1C7 MOT14_MOUSE 5.00E-35 GO:0016021; GO:0005886; GO:0015293 integral to membrane; plasma membrane; symporter activity IPR011701; IPR020846; IPR016196; Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) Slc16a14 Mct14 Mus musculus (Mouse) TR43257_c13_g2_i2 0.638 0.000 0.000 1.846 0.000 0.010 O02768 PGH2_RABIT 0 GO:0042640; GO:0050873; GO:0071456; GO:0019371; GO:0005737; GO:0051213; GO:0005789; GO:0020037; GO:0046872; GO:0043005; GO:0005634; GO:0004601; GO:0090336; GO:0031622; GO:0004666; GO:0008217; GO:0042127; GO:0006979 anagen; brown fat cell differentiation; cellular response to hypoxia; cyclooxygenase pathway; cytoplasm; dioxygenase activity; endoplasmic reticulum membrane; heme binding; metal ion binding; neuron projection; nucleus; peroxidase activity; positive regulation of brown fat cell differentiation; positive regulation of fever generation; prostaglandin-endoperoxide synthase activity; regulation of blood pressure; regulation of cell proliferation; response to oxidative stress IPR000742; IPR010255; IPR002007; IPR019791; Lipid metabolism; prostaglandin biosynthesis. Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX-2 COX2 Oryctolagus cuniculus (Rabbit) TR43258_c2_g1_i1 0.069 0.084 0.000 4.362 0.364 0.000 O72736 KBTB1_CWPXG 2.00E-39 GO:0030430; GO:0039649 host cell cytoplasm; modulation by virus of host ubiquitin-protein ligase activity IPR011705; IPR000210; IPR011333; IPR013069; IPR015915; IPR006652; IPR024182; Kelch repeat and BTB domain-containing protein 1 KBTB1 A57R Cowpox virus (strain GRI-90 / Grishak) (CPV) TR43261_c1_g1_i1 0.125 0.000 0.181 4.240 0.238 0.297 Q9VZI3 UN112_DROME 0 GO:0048738; GO:0050839; GO:0007160; GO:0005737; GO:0050829; GO:0005543 cardiac muscle tissue development; cell adhesion molecule binding; cell-matrix adhesion; cytoplasm; defense response to Gram-negative bacterium; phospholipid binding IPR019749; IPR014352; IPR019748; IPR011993; IPR001849; Unc-112-related protein (Fermitin-1) Fit1 CG14991 Drosophila melanogaster (Fruit fly) TR43261_c1_g1_i8 0.000 0.000 1.588 0.000 0.053 0.000 Q8K1B8 URP2_MOUSE 2.00E-127 GO:0030054; GO:0042995; GO:0033622; GO:0005178; GO:0007159; GO:0005543; GO:0070527; GO:0002102; GO:0033632 cell junction; cell projection; integrin activation; integrin binding; leukocyte cell-cell adhesion; phospholipid binding; platelet aggregation; podosome; regulation of cell-cell adhesion mediated by integrin IPR019749; IPR014352; IPR019748; IPR011993; IPR001849; Fermitin family homolog 3 (Kindlin-3) (Unc-112-related protein 2) Fermt3 Kind3 Urp2 Mus musculus (Mouse) TR43302_c10_g1_i2 0.652 1.391 0.000 6.325 2.073 0.021 O35141 RASF5_RAT 4.00E-49 GO:0006915; GO:0005737; GO:0035556; GO:0046872; GO:0005874; GO:0005634; GO:0031398 apoptotic process; cytoplasm; intracellular signal transduction; metal ion binding; microtubule; nucleus; positive regulation of protein ubiquitination IPR002219; IPR000159; IPR011524; Ras association domain-containing protein 5 (Maxp1) (New ras effector 1) Rassf5 Nore1 Rattus norvegicus (Rat) TR598_c0_g1_i1 0.000 0.367 1.162 0.421 0.215 126.977 O18017 BLM_CAEEL 4.00E-16 GO:0005524; GO:0043140; GO:0003677; GO:0000077; GO:0006281; GO:0006260; GO:0051276; GO:0008340; GO:0051307; GO:0007067; GO:0043066; GO:0005634; GO:0007131; GO:0010165 ATP binding; ATP-dependent 3'-5' DNA helicase activity; DNA binding; DNA damage checkpoint; DNA repair; DNA replication; chromosome organization; determination of adult lifespan; meiotic chromosome separation; mitosis; negative regulation of apoptotic process; nucleus; reciprocal meiotic recombination; response to X-ray IPR011545; IPR002464; IPR004589; IPR014001; IPR001650; IPR010997; IPR002121; IPR027417; IPR018982; IPR011991; Bloom syndrome protein homolog (EC 3.6.4.12) (High incidence of males protein 6) (RecQ helicase homolog) him-6 T04A11.6 Caenorhabditis elegans